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Search of human proteins with 148539628
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
(904 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1794 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1761 0.0
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 1168 0.0
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 1150 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 1084 0.0
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 1068 0.0
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 1062 0.0
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 1047 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 702 0.0
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 547 e-155
gi|95089461 discs large homolog 5 [Homo sapiens] 212 1e-54
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 206 8e-53
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 186 8e-47
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 167 4e-41
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 165 2e-40
gi|45827729 scribble isoform b [Homo sapiens] 164 3e-40
gi|45827731 scribble isoform a [Homo sapiens] 164 3e-40
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 164 3e-40
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 158 2e-38
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 151 3e-36
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 150 5e-36
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 150 5e-36
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 149 9e-36
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 147 3e-35
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 146 1e-34
gi|112382257 InaD-like [Homo sapiens] 139 1e-32
gi|148746189 multiple PDZ domain protein [Homo sapiens] 138 3e-32
gi|10092691 tight junction protein 3 [Homo sapiens] 137 3e-32
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 133 9e-31
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 133 9e-31
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1794 bits (4646), Expect = 0.0
Identities = 904/904 (100%), Positives = 904/904 (100%)
Query: 1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL 60
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL
Sbjct: 1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL 60
Query: 61 LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH 120
LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH
Sbjct: 61 LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH 120
Query: 121 ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP 180
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
Sbjct: 121 ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP 180
Query: 181 VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG 240
VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG
Sbjct: 181 VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG 240
Query: 241 GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG 300
GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
Sbjct: 241 GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG 300
Query: 301 SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 360
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH
Sbjct: 301 SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 360
Query: 361 KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT 420
KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT
Sbjct: 361 KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT 420
Query: 421 NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
Sbjct: 421 NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
Query: 481 VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT
Sbjct: 481 VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Query: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600
IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600
Query: 601 PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF 660
PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
Sbjct: 601 PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF 660
Query: 661 NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL 720
NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL
Sbjct: 661 NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL 720
Query: 721 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE 780
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE
Sbjct: 721 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE 780
Query: 781 AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME 840
AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME
Sbjct: 781 AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME 840
Query: 841 MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900
MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA
Sbjct: 841 MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900
Query: 901 KEKL 904
KEKL
Sbjct: 901 KEKL 904
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1761 bits (4560), Expect = 0.0
Identities = 895/926 (96%), Positives = 898/926 (96%), Gaps = 22/926 (2%)
Query: 1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL 60
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL
Sbjct: 1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL 60
Query: 61 LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH 120
LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH
Sbjct: 61 LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH 120
Query: 121 ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP 180
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
Sbjct: 121 ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP 180
Query: 181 VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG 240
VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG
Sbjct: 181 VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG 240
Query: 241 GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG 300
GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
Sbjct: 241 GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG 300
Query: 301 SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 360
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH
Sbjct: 301 SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 360
Query: 361 KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT 420
KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT
Sbjct: 361 KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT 420
Query: 421 NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
Sbjct: 421 NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI 480
Query: 481 VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT
Sbjct: 481 VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Query: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600
IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600
Query: 601 PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF 660
PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
Sbjct: 601 PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF 660
Query: 661 NSKTRDKGEIPDDMGSKGL----------------------KHVTSNASDSESSYRGQEE 698
NSKTRDKG+ +D K L +HVTSNASDSESSYRGQEE
Sbjct: 661 NSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEE 720
Query: 699 YVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGR 758
YVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGR
Sbjct: 721 YVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGR 780
Query: 759 DYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRL 818
DYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRL
Sbjct: 781 DYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRL 840
Query: 819 QIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLE 878
QIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLE
Sbjct: 841 QIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLE 900
Query: 879 DIYNQVKQIIEEQSGSYIWVPAKEKL 904
DIYNQVKQIIEEQSGSYIWVPAKEKL
Sbjct: 901 DIYNQVKQIIEEQSGSYIWVPAKEKL 926
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 1168 bits (3022), Expect = 0.0
Identities = 627/1010 (62%), Positives = 729/1010 (72%), Gaps = 178/1010 (17%)
Query: 38 INIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSL---------- 87
+ IF+S+LFQAL+DIQEFYEVTLL++ K ++ K E Q + WE +SL
Sbjct: 1 MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQ-KIEEANQVLQKWEKTSLLAPCHDRLQK 59
Query: 88 ------------------------------PSSTVTSETLPSSLSPSVE----------- 106
+T ++ + + SVE
Sbjct: 60 SSELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCT 119
Query: 107 KYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAV 166
KYRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP+K
Sbjct: 120 KYRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLK----- 173
Query: 167 LPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT 226
A+P P++VNTD+L+T YVNGT+ +YE+EEIT
Sbjct: 174 ----------------------------ASPAPIIVNTDTLDTIPYVNGTEIEYEFEEIT 205
Query: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
LERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRVNEVDV +
Sbjct: 206 LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 265
Query: 287 VTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDN 346
V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGNQHIPGDN
Sbjct: 266 VSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDN 325
Query: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT 406
SIYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VYLKV KPT
Sbjct: 326 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPT 385
Query: 407 SMYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF------------- 436
++YM D Y PPDIT+S S P++NH +SP +
Sbjct: 386 TIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDY 445
Query: 437 -------------LGQTPASPARYSPVS---------------KAVLGDDEITR------ 462
L PASP YSPV +L D E+T
Sbjct: 446 TRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHST 505
Query: 463 -----------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGE 505
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGE
Sbjct: 506 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGE 565
Query: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMM 565
L++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIHDLREQMM
Sbjct: 566 LQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMM 625
Query: 566 NSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQ 625
N S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINASDDEWWQ
Sbjct: 626 NHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQ 685
Query: 626 ARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR---DKGEIPDDMGSKGL--- 679
AR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K KG D +
Sbjct: 686 ARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSR 745
Query: 680 -----KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISE 734
K+ + ++ RGQE+ +LSYEPV +QE+NYTRPVIILGPMKDRINDDLISE
Sbjct: 746 KFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISE 805
Query: 735 FPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQ 794
FPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEAGQYN++LYGTSVQ
Sbjct: 806 FPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQ 865
Query: 795 SVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTF 854
SVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEMNKRLTEEQA+KT+
Sbjct: 866 SVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTY 925
Query: 855 ERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
+RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 926 DRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 975
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 1150 bits (2975), Expect = 0.0
Identities = 598/897 (66%), Positives = 688/897 (76%), Gaps = 126/897 (14%)
Query: 100 SLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISP 159
+L +V+KYRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP
Sbjct: 8 ALRTNVKKYRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISP 66
Query: 160 IKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDAD 219
+K A+P P++VNTD+L+T YVNGT+ +
Sbjct: 67 LK---------------------------------ASPAPIIVNTDTLDTIPYVNGTEIE 93
Query: 220 YEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
YE+EEITLERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRV
Sbjct: 94 YEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 153
Query: 280 NEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGN 339
NEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGN
Sbjct: 154 NEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGN 213
Query: 340 QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVY 399
QHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VY
Sbjct: 214 QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVY 273
Query: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF------ 436
LKV KPT++YM D Y PPDIT+S S P++NH +SP +
Sbjct: 274 LKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKH 333
Query: 437 --------------------LGQTPASPARYSPVS---------------KAVLGDDEIT 461
L PASP YSPV +L D E+T
Sbjct: 334 MLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMT 393
Query: 462 R-----------------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGG 498
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGG
Sbjct: 394 SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGG 453
Query: 499 PADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIH 558
PADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIH
Sbjct: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513
Query: 559 DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA 618
DLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINA
Sbjct: 514 DLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA 573
Query: 619 SDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR---DKGEIPDDMG 675
SDDEWWQAR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K KG D
Sbjct: 574 SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRK 633
Query: 676 SKGL--------KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRI 727
+ K+ + ++ RGQE+ +LSYEPV +QE+NYTRPVIILGPMKDRI
Sbjct: 634 KSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRI 693
Query: 728 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNH 787
NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEAGQYN++
Sbjct: 694 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDN 753
Query: 788 LYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTE 847
LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEMNKRLTE
Sbjct: 754 LYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTE 813
Query: 848 EQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
EQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 814 EQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 1084 bits (2804), Expect = 0.0
Identities = 545/724 (75%), Positives = 619/724 (85%), Gaps = 42/724 (5%)
Query: 213 VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRV 272
VNGT+ +YE+EEITLERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRV
Sbjct: 36 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
Query: 273 NDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFS 332
NDCILRVNEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFS
Sbjct: 96 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
Query: 333 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALK 392
IAGGVGNQHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 393 NTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF------LGQTPASPAR 446
NTS+ VYLKV KPT++YM D Y PPDIT+S S P++NH+ + P SP R
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 447 YSPVSKAVLGDDEITR-----------------------EPRKVVLHRGSTGLGFNIVGG 483
YSP+ K +L DD+ T EPRKVVLH+GSTGLGFNIVGG
Sbjct: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
Query: 484 EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVA 543
EDGEGIF+SFILAGGPADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+A
Sbjct: 336 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395
Query: 544 QYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ 603
QY+PE+Y+RFEAKIHDLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQ
Sbjct: 396 QYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ 455
Query: 604 GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663
GL+FK+GDILHVINASDDEWWQAR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K
Sbjct: 456 GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAK 515
Query: 664 TR---DKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL 720
KG+IP +G G + RGQE+ +LSYEPV +QE+NYTRPVIIL
Sbjct: 516 PGVIDSKGDIPG-LGDDGY---------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
Query: 721 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE 780
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIE
Sbjct: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
Query: 781 AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME 840
AGQYN++LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +ME
Sbjct: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
Query: 841 MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900
MNKRLTEEQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+
Sbjct: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Query: 901 KEKL 904
KEKL
Sbjct: 746 KEKL 749
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 1068 bits (2761), Expect = 0.0
Identities = 530/717 (73%), Positives = 615/717 (85%), Gaps = 33/717 (4%)
Query: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
QAN PPV+VNTD+LE P YVNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD SI
Sbjct: 32 QANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSI 91
Query: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
FITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RRKP
Sbjct: 92 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPP 151
Query: 314 SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLA 373
+EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK+LA
Sbjct: 152 AEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 211
Query: 374 VNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433
VN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN +S
Sbjct: 212 VNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISH 271
Query: 434 SSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGE 487
SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGEDGE
Sbjct: 272 SSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE 331
Query: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
GIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQY+P
Sbjct: 332 GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 391
Query: 548 EEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNF 607
EEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ L+F
Sbjct: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
Query: 608 KFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDK 667
+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K +D
Sbjct: 452 RFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KAKDW 504
Query: 668 GEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRI 727
G S S +G+E+ VLSYE V Q EV+Y RP+IILGP KDR
Sbjct: 505 G--------------------SSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRA 544
Query: 728 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNH 787
NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV+SRE+MEKDIQ HKFIEAGQYN+H
Sbjct: 545 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 604
Query: 788 LYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTE 847
LYGTSVQSVREVAE+GKHCILDVS NA++RLQ A L+PI+IFI+P+S+EN++E+NKR+TE
Sbjct: 605 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 664
Query: 848 EQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
EQARK F+RA KLEQEFTE F+AIV+GD+ E+IY++VK++IE+ SG YIWVPA+E+L
Sbjct: 665 EQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
Score = 134 bits (338), Expect = 3e-31
Identities = 108/383 (28%), Positives = 162/383 (42%), Gaps = 95/383 (24%)
Query: 104 SVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSE---IENVHGFVSHSHISPI 160
+ +KYRYQDEDTPP EH + N+ P ++ V+ L + G + + I+
Sbjct: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYVNGTEGEMEYEEITLE 66
Query: 161 KPTEAV------------LPSPPTVPVIPVLPVPAE---------------NTVILPTIP 193
+ + + P++ + ++P A N V + +
Sbjct: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
Query: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
+ L S+ + + EI L +G GLGFSIAGG N HI D+SI
Sbjct: 127 HSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSI 186
Query: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV------ 307
++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V L V
Sbjct: 187 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA 246
Query: 308 ------------------------------------------KRRKPVSEKIM------- 318
+R PV++ ++
Sbjct: 247 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 306
Query: 319 ---EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
I + +G GLGF+I GG + I+++ I+ GG A G+L+ GD++L+VN
Sbjct: 307 EPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKGDQILSVN 360
Query: 376 NVCLEEVTHEEAVTALKNTSDFV 398
V L +HE+A ALKN V
Sbjct: 361 GVDLRNASHEQAAIALKNAGQTV 383
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 1062 bits (2747), Expect = 0.0
Identities = 530/720 (73%), Positives = 615/720 (85%), Gaps = 36/720 (5%)
Query: 194 QANPPPVLVNTDSLETPTY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDD 250
QAN PPV+VNTD+LE P Y VNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD
Sbjct: 75 QANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDD 134
Query: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
SIFITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RR
Sbjct: 135 PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194
Query: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
KP +EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK
Sbjct: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNH 430
+LAVN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
Query: 431 VSPSSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE 484
+S SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGE
Sbjct: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE 374
Query: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
DGEGIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQ
Sbjct: 375 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Query: 545 YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQG 604
Y+PEEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ
Sbjct: 435 YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQA 494
Query: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
L+F+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K
Sbjct: 495 LSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KA 547
Query: 665 RDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMK 724
+D G S S +G+E+ VLSYE V Q EV+Y RP+IILGP K
Sbjct: 548 KDWG--------------------SSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTK 587
Query: 725 DRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQY 784
DR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV+SRE+MEKDIQ HKFIEAGQY
Sbjct: 588 DRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQY 647
Query: 785 NNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR 844
N+HLYGTSVQSVREVAE+GKHCILDVS NA++RLQ A L+PI+IFI+P+S+EN++E+NKR
Sbjct: 648 NSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR 707
Query: 845 LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
+TEEQARK F+RA KLEQEFTE F+AIV+GD+ E+IY++VK++IE+ SG YIWVPA+E+L
Sbjct: 708 ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
Score = 140 bits (352), Expect = 7e-33
Identities = 119/453 (26%), Positives = 183/453 (40%), Gaps = 140/453 (30%)
Query: 37 VINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSET 96
++ + S+LFQAL+DI ++YE +L ++
Sbjct: 26 LLTVLHSDLFQALLDILDYYEASLSES--------------------------------- 52
Query: 97 LPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLS------EIENVHG 150
+KYRYQDEDTPP EH + N+ P ++ V+ L ++ G
Sbjct: 53 ---------QKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYELQVNGTEG 102
Query: 151 FVSHSHISPIKPTEAV------------LPSPPTVPVIPVLPVPAE-------------- 184
+ + I+ + + + P++ + ++P A
Sbjct: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 185 -NTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTD 243
N V + + + L S+ + + EI L +G GLGFSIAGG
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVG 222
Query: 244 NPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIV 303
N HI D+SI++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V
Sbjct: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
Query: 304 RLYV------------------------------------------------KRRKPVSE 315
L V +R PV++
Sbjct: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342
Query: 316 KIM----------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
++ I + +G GLGF+I GG + I+++ I+ GG A G+L
Sbjct: 343 DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGEL 396
Query: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
+ GD++L+VN V L +HE+A ALKN V
Sbjct: 397 RKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 1047 bits (2708), Expect = 0.0
Identities = 533/767 (69%), Positives = 632/767 (82%), Gaps = 25/767 (3%)
Query: 153 SHSHISPIKPTEA-VLPSPPTVPVIPVLPVPAENTVILP-TIPQANPPPVLVNTDSLETP 210
S + +P T+A ++P+ V +P PVP ++T L + P P N D E
Sbjct: 61 SQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPECTCTNRDWYEQ- 119
Query: 211 TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRL 270
VNG+D ++YEEI LERGNSGLGFSIAGG DNPH+ DD IFITKII GGAAA DGRL
Sbjct: 120 --VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRL 177
Query: 271 RVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLG 330
VNDC+LRVNEVDV +V HS+AVEALKEAG +VRL V+RR+P E IME+ L+KGPKGLG
Sbjct: 178 GVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLG 237
Query: 331 FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTA 390
FSIAGG+GNQHIPGDNSIY+TKIIEGGAA KDG+LQIGD+LLAVNN L++V HEEAV +
Sbjct: 238 FSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAS 297
Query: 391 LKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPA-------- 442
LKNTSD VYLKVAKP S+++ND YAPPD ++ + DNH+S +S LG A
Sbjct: 298 LKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP 357
Query: 443 -----SPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
P RYSP+ + +L +++ TREPRK++LH+GSTGLGFNIVGGEDGEGIF+SFILAG
Sbjct: 358 APPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAG 417
Query: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
GPADLSGELR+GDRI+SVN V+LR A+HEQAAAALK AGQ+VTIVAQYRPEEYSRFE+KI
Sbjct: 418 GPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
Query: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVIN 617
HDLREQMMNSS+SSGSGSLRTS+KRSLYVRALFDYD+T+DS LPSQGL+F +GDILHVIN
Sbjct: 478 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 537
Query: 618 ASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSK 677
ASDDEWWQAR VTP GES+++GVIPSK+RVEKKERARLKTVKF+++T G I +
Sbjct: 538 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHART---GMIESNRDFP 594
Query: 678 GLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPD 737
GL S+ + +GQE+ +LSYEPV +QE++Y RPVIILGPMKDR+NDDLISEFP
Sbjct: 595 GL----SDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH 650
Query: 738 KFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVR 797
KFGSCVPHTTRP+RD EVDG+DYHFV SREQMEKDIQ++KFIEAGQ+N++LYGTS+QSVR
Sbjct: 651 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 710
Query: 798 EVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERA 857
VAE+GKHCILDVSGNAIKRLQ AQLYPI+IFIKPKS+E +MEMN+R T EQA K +++A
Sbjct: 711 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKA 770
Query: 858 MKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
MKLEQEF E+FTAIVQGD+LE+IYN++KQIIE+QSG YIWVP+ EKL
Sbjct: 771 MKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 702 bits (1812), Expect = 0.0
Identities = 350/468 (74%), Positives = 406/468 (86%), Gaps = 25/468 (5%)
Query: 462 REPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLR 521
REPRK++LH+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGELR+GDRI+SVN V+LR
Sbjct: 45 REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 104
Query: 522 AASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQK 581
A+HEQAAAALK AGQ+VTIVAQYRPEEYSRFE+KIHDLREQMMNSS+SSGSGSLRTS+K
Sbjct: 105 NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 164
Query: 582 RSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVI 641
RSLYVRALFDYD+T+DS LPSQGL+F +GDILHVINASDDEWWQAR VTP GES+++GVI
Sbjct: 165 RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI 224
Query: 642 PSKRRVEKKERARLKTVKFNSKT-----------------RDKGEIPDDMGSKGLKH--- 681
PSK+RVEKKERARLKTVKF+++T R + P + +
Sbjct: 225 PSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESS 284
Query: 682 -----VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP 736
VTSN SDSESS +GQE+ +LSYEPV +QE++Y RPVIILGPMKDR+NDDLISEFP
Sbjct: 285 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP 344
Query: 737 DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSV 796
KFGSCVPHTTRP+RD EVDG+DYHFV SREQMEKDIQ++KFIEAGQ+N++LYGTS+QSV
Sbjct: 345 HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV 404
Query: 797 REVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFER 856
R VAE+GKHCILDVSGNAIKRLQ AQLYPI+IFIKPKS+E +MEMN+R T EQA K +++
Sbjct: 405 RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK 464
Query: 857 AMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
AMKLEQEF E+FTAIVQGD+LE+IYN++KQIIE+QSG YIWVP+ EKL
Sbjct: 465 AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 70.1 bits (170), Expect = 9e-12
Identities = 47/136 (34%), Positives = 71/136 (52%), Gaps = 8/136 (5%)
Query: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
E +I L +G++GLGF+I GG D IF++ I+ GG A G LR D IL VN
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDG------EGIFVSFILAGGPADLSGELRRGDRILSVN 99
Query: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIK-GPKGLGFSIAGGVGN 339
V++R+ TH +A ALK AG V + V + +P E K+ + + S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158
Query: 340 QHIPGDNSIYVTKIIE 355
S+YV + +
Sbjct: 159 LRTSEKRSLYVRALFD 174
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/80 (42%), Positives = 46/80 (57%), Gaps = 6/80 (7%)
Query: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
+I L KG GLGF+I GG + I+V+ I+ GG A G+L+ GD++L+VN V
Sbjct: 49 KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 379 LEEVTHEEAVTALKNTSDFV 398
L THE+A ALK V
Sbjct: 103 LRNATHEQAAAALKRAGQSV 122
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 547 bits (1409), Expect = e-155
Identities = 271/344 (78%), Positives = 308/344 (89%), Gaps = 13/344 (3%)
Query: 564 MMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEW 623
MMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINASDDEW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 624 WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR---DKGEIPDDMGSKGLK 680
WQAR+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K KG+IP +G G
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPG-LGDDGY- 118
Query: 681 HVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFG 740
+ RGQE+ +LSYEPV +QE+NYTRPVIILGPMKDRINDDLISEFPDKFG
Sbjct: 119 --------GTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG 170
Query: 741 SCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVA 800
SCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEAGQYN++LYGTSVQSVR VA
Sbjct: 171 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA 230
Query: 801 EKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKL 860
E+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEMNKRLTEEQA+KT++RA+KL
Sbjct: 231 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL 290
Query: 861 EQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
EQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 291 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 212 bits (539), Expect = 1e-54
Identities = 167/633 (26%), Positives = 292/633 (46%), Gaps = 95/633 (15%)
Query: 308 KRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367
++ +P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+
Sbjct: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
Query: 368 GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPV 427
GD+LL N + L T ++A + D + + ++ ++ ++S P
Sbjct: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSR---SSSHLDPA 1447
Query: 428 DNHVSPSSFLGQTPASPARYSPV---------------SKAVLGD-DEITREPRKVVLHR 471
H + TP P+ P+ S + GD ++ T EPR V + +
Sbjct: 1448 GTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKK 1507
Query: 472 GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAA 531
LG ++ GG + G+F++ + PA L GD I+ S+D+R + E+
Sbjct: 1508 SQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE 1566
Query: 532 LKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFD 591
+ V + QYRPEE+++ + D S Y+RAL
Sbjct: 1567 MLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYIRAL-- 1601
Query: 592 YDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVE 648
YD+ D Q L+FK DIL+V + W A Q+ + + + G IPSK ++
Sbjct: 1602 YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMD 1658
Query: 649 KKERARLKTVKF---NSKTRDKGEIP-----------DDMGSKGLKHVTS-NASDSESSY 693
++ RL + NS T+ GSK K + + +A S+S
Sbjct: 1659 QEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIP 1718
Query: 694 RGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDY 753
++ L+Y+ V + + RPV+ILGP+ D + + L++E P KF C +
Sbjct: 1719 LFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK----- 1773
Query: 754 EVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGN 813
S++ +E+ +++ F++ + + H T+V S++E+ EK +HC+LD++ +
Sbjct: 1774 ----------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPH 1823
Query: 814 AIKRLQIAQLYPISIFIKPKSMENIME------MNKRLTEEQARKTFERAMKLEQEFTEH 867
AI+RL +YPI IFI KS ++I E + ++T+ +++ FE A KLEQE++ +
Sbjct: 1824 AIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRY 1883
Query: 868 FTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900
FT ++QG L I Q+ ++ ++ +W+PA
Sbjct: 1884 FTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 106 bits (264), Expect = 1e-22
Identities = 67/206 (32%), Positives = 111/206 (53%), Gaps = 23/206 (11%)
Query: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261
++TDS+E T V + + E E+I L+ LGF +A G + P D IF+TK+ G
Sbjct: 609 IDTDSMEWETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKG 662
Query: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI---M 318
A DGRLRVND +LR+N+VD+ + +A++AL + + V+RRK + K+ +
Sbjct: 663 SIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
Query: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
I L G K G S+ +N +Y ++ G A K+G L +GD+++A+N +
Sbjct: 721 HINL-SGQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
Query: 379 LEEVTHEEAVTALKNTSDFVYLKVAK 404
L+ + E + L++ D + L + K
Sbjct: 769 LDNKSLNECESLLRSCQDSLTLSLLK 794
Score = 61.2 bits (147), Expect = 4e-09
Identities = 54/215 (25%), Positives = 89/215 (41%), Gaps = 57/215 (26%)
Query: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
K LGF +A GV PGD I+VTK+ +G A DG+L++ D LL +N+V L ++
Sbjct: 633 KALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQ 690
Query: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
A+ AL N + + V + S LG +P
Sbjct: 691 AIKALLNGEGAINMVVRRRKS-----------------------------LGGKVVTP-- 719
Query: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
LH +G + + E+G ++ + +L G PA G L
Sbjct: 720 ----------------------LHINLSGQKDSGISLENG--VYAAAVLPGSPAAKEGSL 755
Query: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
GDRI+++N + L S + + L++ ++T+
Sbjct: 756 AVGDRIVAINGIALDNKSLNECESLLRSCQDSLTL 790
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 206 bits (524), Expect = 8e-53
Identities = 136/427 (31%), Positives = 221/427 (51%), Gaps = 44/427 (10%)
Query: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546
+ + IS I+ GG A+ SG L +GD ++ +N +++R + L + +T V
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL--- 332
Query: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--G 604
I S +++ ++V+A FDYD + D +P + G
Sbjct: 333 ----------------------IPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELG 370
Query: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
L+F+ GDILHVI+ D WWQA + + G++P K +++E A +T++ + +
Sbjct: 371 LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQRE-AMKQTIEEDKEP 429
Query: 665 RDKGEI-PDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVN--QQEVNYTRPVIILG 721
G++ K K V NA+ ++ E +L+YE ++ Q N RP+I++G
Sbjct: 430 EKSGKLWCAKKNKKKRKKVLYNANKNDDY---DNEEILTYEEMSLYHQPANRKRPIILIG 486
Query: 722 PM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
P ++ + L+++ D+F S VPHTTR +RD EV GRDYHFV SR+ E DI KF
Sbjct: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKF 545
Query: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
IE G++ +LYGTS+ SVR+V GK C+L + ++K L+ + L P IFI P S E +
Sbjct: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
Query: 839 MEM----NKRLTEEQARKTFERAMKLEQEFTEHF-TAIVQGDTLEDIYNQVKQIIEEQSG 893
+ K E+ R+ E+ ++EQ +F TAIV D L+ Y ++ ++I +
Sbjct: 606 RALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDT 664
Query: 894 SYIWVPA 900
WVP+
Sbjct: 665 EPQWVPS 671
Score = 37.0 bits (84), Expect = 0.083
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNV 377
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 186 bits (472), Expect = 8e-47
Identities = 137/481 (28%), Positives = 217/481 (45%), Gaps = 57/481 (11%)
Query: 447 YSPVSKAVLGDDEITREPRKVV-LHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGE 505
Y PV + D + + K++ L + LG I E I ++ I+ GG AD SG
Sbjct: 119 YDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGL 178
Query: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMM 565
+ GD + VN + + E+ L + A+T
Sbjct: 179 IHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITF------------------------ 214
Query: 566 NSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEW 623
I GS S++ ++++ALFDY+ +D +P + GL+FK GDIL +++ D W
Sbjct: 215 --KIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATW 272
Query: 624 WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFN----SKTRDKGEIPDDMGSKGL 679
WQA+ + G+IPSK E++ R + S + G S+
Sbjct: 273 WQAKHEAD--ANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKD 330
Query: 680 KHVTSNASDSESSYRGQEEYVLSYE---PVNQQEVNYTRPVIILGPMKDRIND---DLIS 733
K + + + S + V +YE P +Q R V+++GP+ +N+ L+
Sbjct: 331 KKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLI 390
Query: 734 EFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSV 793
+G VPHTTR +R E DG +Y F+ S+ E D+Q +KFIE G+Y N+ YGTS+
Sbjct: 391 SDTQHYGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKFIEYGEYKNNYYGTSI 449
Query: 794 QSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR--------- 844
SVR V K K C+LDV + +K L+ + P IFIKP S+E + E K
Sbjct: 450 DSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDD 509
Query: 845 ------LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV 898
TEE ++ + A +E ++ F I+ D L +N++K ++ WV
Sbjct: 510 QGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWV 569
Query: 899 P 899
P
Sbjct: 570 P 570
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 315 EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
+ + I+L+K + LG +I + +I V +I+ GGAA + G + +GD+L V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
Query: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKV 402
N + +E+ EE + L + + K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 167 bits (423), Expect = 4e-41
Identities = 125/484 (25%), Positives = 226/484 (46%), Gaps = 71/484 (14%)
Query: 457 DDEITREPRKVV-LHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISV 515
D++ E K+V L + LG I E + ++ I+ GG AD SG + GD + V
Sbjct: 127 DEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 516 NSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGS 575
N + + ++ + L + ++T+ +E R +
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLK--------------------- 225
Query: 576 LRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDG 633
+ +++RALF Y+ +D +P Q GL F+ +L V++ D WWQA++V G
Sbjct: 226 -----ESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV---G 277
Query: 634 ESD-EVGVIPSKRRVEKK---ERARLKTVKFNSKTRDKGEIPDDMGS------------- 676
+++ G+IPSK E++ RA S + + P D +
Sbjct: 278 DTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVA 337
Query: 677 -------KGLKHVTSNASDSESSYRGQEEYVLSYEPV---NQQEVNYTRPVIILGPMKDR 726
G + + + + S + +L+YE V Q R V+++G + R
Sbjct: 338 GLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGAR 397
Query: 727 IND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQ 783
+++ +++E P FG VPHTTRP++ +E +G +YHFV S++ E D+ +KF+E G+
Sbjct: 398 LHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFV-SKQAFEADLHHNKFLEHGE 456
Query: 784 YNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMEN------ 837
Y +LYGTS+++++ V K K C++DV A+K+L+ ++ P IF+KP E
Sbjct: 457 YKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPM 516
Query: 838 --IMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSY 895
E +EQ ++ A +++ + A++ + L+ Y+Q+K ++E+ S
Sbjct: 517 SPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDT 576
Query: 896 IWVP 899
WVP
Sbjct: 577 HWVP 580
Score = 40.4 bits (93), Expect = 0.008
Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 315 EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
E + ++L+K + LG +I ++H ++ V +I+ GGAA + G + +GD+L V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT 406
N + + +E L + + LK+ T
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKIIPAT 218
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 165 bits (418), Expect = 2e-40
Identities = 122/442 (27%), Positives = 207/442 (46%), Gaps = 63/442 (14%)
Query: 475 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKN 534
G+ F + GGE + I+ IL GG G L GD I VN + + L+N
Sbjct: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
Query: 535 AGQAVT--IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDY 592
A +V I+ Y+ R ++V+ FDY
Sbjct: 207 ASGSVILKILPSYQEPHLPR------------------------------QVFVKCHFDY 236
Query: 593 DKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKK 650
D +DS +P + GL F GD+L ++N D WWQA V E G+IPS+ EK+
Sbjct: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV----EGGSAGLIPSQLLEEKR 292
Query: 651 ERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQE 710
+ + ++ T + G + + K K + + + R + +L YE V +
Sbjct: 293 KAFVKRDLEL---TPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHE---LLIYEEVARMP 346
Query: 711 VNYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSRE 767
+ ++++G + + + LI PD++G+ VP+T+R +D E +G+ Y FV SR
Sbjct: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFV-SRG 405
Query: 768 QMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPIS 827
+ME D++ +++E G+Y +LYGT + S+R V GK C+LDV+ A+K L+ A+ P
Sbjct: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
Query: 828 IFIKPKSMENIMEMN----------KRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTL 877
+FI+ E + MN K+LTE R+T E + ++++ + +F + L
Sbjct: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
Query: 878 EDIYNQVKQIIEEQSGSYIWVP 899
E + +++ +E+ WVP
Sbjct: 526 ERTFRELQTAMEKLRTEPQWVP 547
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 164 bits (415), Expect = 3e-40
Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)
Query: 218 ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274
A E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D
Sbjct: 720 ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
Query: 275 CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321
+L VN V ++ H +AVEAL+ AG+ V++ V R + V E + I
Sbjct: 779 KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Query: 322 --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354
L + +GLGFSIAGG G+ + GD I+V++I
Sbjct: 839 RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
Query: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414
EGGAAH+ G LQ+GD++L++N V + E H+ AV+ L S + L + + G
Sbjct: 899 EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
Query: 415 APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474
PP SS P V+ +S TP P S + E ++ L R
Sbjct: 954 LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
Query: 475 GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
LG +IVGG D G+FIS +L G A SG LR GDRI++VN D+R A+H
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
Query: 526 EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573
++A +AL ++++ + P E I + + SI G+
Sbjct: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
Score = 126 bits (316), Expect = 1e-28
Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)
Query: 130 IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187
+G ++ ++ +++E + H S ++ PT A+L +P P+P + T
Sbjct: 911 VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
Query: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244
+ T P + SL + Y EEI L R LG SI GG+D+
Sbjct: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
Query: 245 PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304
P + +FI+K++ G AA+ G LRV D IL VN DVRD TH +AV AL +
Sbjct: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
Query: 305 LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359
L V RR P + E+ + K P + LG SI GG GN P D I+++K+ GAA
Sbjct: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
Query: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
+DG+L++G +LL VN L +TH EAV L++ D
Sbjct: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Score = 112 bits (280), Expect = 2e-24
Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)
Query: 227 LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
L R GLGFSIAGG + P+ D+ IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 286 DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316
+ H AV L A + L ++R P+
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 317 -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356
+ EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
G A + G L++GD++LAVN + + TH+EAV+AL L+ S+ + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
Query: 417 PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476
P + Q +P LG + AR G R+P
Sbjct: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
Query: 477 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
EGIFIS + G A G LR G R++ VN L +H +A L++ G
Sbjct: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Query: 537 QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593
+T++ FEA ++ ++ + ++G G + + S R L
Sbjct: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
Query: 594 KTKDSGLPSQGLNF 607
K+ LP Q L++
Sbjct: 1236 PGKEKELPGQTLHW 1249
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 164 bits (415), Expect = 3e-40
Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)
Query: 218 ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274
A E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D
Sbjct: 720 ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
Query: 275 CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321
+L VN V ++ H +AVEAL+ AG+ V++ V R + V E + I
Sbjct: 779 KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Query: 322 --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354
L + +GLGFSIAGG G+ + GD I+V++I
Sbjct: 839 RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
Query: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414
EGGAAH+ G LQ+GD++L++N V + E H+ AV+ L S + L + + G
Sbjct: 899 EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
Query: 415 APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474
PP SS P V+ +S TP P S + E ++ L R
Sbjct: 954 LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
Query: 475 GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
LG +IVGG D G+FIS +L G A SG LR GDRI++VN D+R A+H
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
Query: 526 EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573
++A +AL ++++ + P E I + + SI G+
Sbjct: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
Score = 126 bits (316), Expect = 1e-28
Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)
Query: 130 IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187
+G ++ ++ +++E + H S ++ PT A+L +P P+P + T
Sbjct: 911 VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
Query: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244
+ T P + SL + Y EEI L R LG SI GG+D+
Sbjct: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
Query: 245 PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304
P + +FI+K++ G AA+ G LRV D IL VN DVRD TH +AV AL +
Sbjct: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
Query: 305 LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359
L V RR P + E+ + K P + LG SI GG GN P D I+++K+ GAA
Sbjct: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
Query: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
+DG+L++G +LL VN L +TH EAV L++ D
Sbjct: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
Score = 112 bits (280), Expect = 2e-24
Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)
Query: 227 LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
L R GLGFSIAGG + P+ D+ IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 286 DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316
+ H AV L A + L ++R P+
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 317 -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356
+ EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
G A + G L++GD++LAVN + + TH+EAV+AL L+ S+ + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
Query: 417 PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476
P + Q +P LG + AR G R+P
Sbjct: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
Query: 477 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
EGIFIS + G A G LR G R++ VN L +H +A L++ G
Sbjct: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Query: 537 QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593
+T++ FEA ++ ++ + ++G G + + S R L
Sbjct: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
Query: 594 KTKDSGLPSQGLNF 607
K+ LP Q L++
Sbjct: 1236 PGKEKELPGQTLHW 1249
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 164 bits (415), Expect = 3e-40
Identities = 135/505 (26%), Positives = 222/505 (43%), Gaps = 99/505 (19%)
Query: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
R V L + LG I E I ++ I+ GG A+ SG L GD+++ VN V +
Sbjct: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
Query: 525 HEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSL 584
EQ + I+A R K+ + + +NS ++ +
Sbjct: 213 PEQV----------IHILAMSR----GTIMFKVVPVSDPPVNS-------------QQMV 245
Query: 585 YVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIP 642
YVRA+ +Y +D +P GL F+ GDIL +++ +D WWQAR+++ G++P
Sbjct: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATC--AGLVP 303
Query: 643 SKRRVEKKERARLKTVKFNSKTRDKG------EIPDDMG-SKGLKHVTSNASDSESSYRG 695
S +++K+R + + T K E DDM + +SE
Sbjct: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
Query: 696 QEEYV------------------------------------------LSYEPV---NQQE 710
+EE+V YE V ++
Sbjct: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
Query: 711 VNYTRPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSRE 767
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
Query: 768 QMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPIS 827
E I H+ +E G+Y HLYGTSV +V+ V +GK C++D+ I+ ++ +L P
Sbjct: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
Query: 828 IFIKPKSMENIMEMNK------------RLTEEQARKTFERAMKLEQEFTEHFTAIVQGD 875
IFIKP +M + + K + +E ++ A ++E +F + F ++ D
Sbjct: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
Query: 876 TLEDIYNQVKQIIEEQSGSYIWVPA 900
+L D Q+ I++ WVPA
Sbjct: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
Score = 45.8 bits (107), Expect = 2e-04
Identities = 33/92 (35%), Positives = 47/92 (51%), Gaps = 7/92 (7%)
Query: 312 PVSEKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
P SE+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
Query: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
L+ VN V +E + E+ + L + + KV
Sbjct: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 158 bits (400), Expect = 2e-38
Identities = 121/432 (28%), Positives = 202/432 (46%), Gaps = 61/432 (14%)
Query: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT--IV 542
+ + I+ IL GG D G L GD I VN ++ + ++ LKN +VT I+
Sbjct: 148 ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKIL 206
Query: 543 AQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPS 602
YR T + ++V+ FDY+ D+ +P
Sbjct: 207 PSYRD------------------------------TITPQQVFVKCHFDYNPYNDNLIPC 236
Query: 603 Q--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF 660
+ GL F G+IL ++N D WWQA V G + G+IPS+ +E+K +A ++
Sbjct: 237 KEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSA---GLIPSQF-LEEKRKAFVRRDWD 292
Query: 661 NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL 720
NS G I K + T NA + YE V + + ++++
Sbjct: 293 NSGPFC-GTISSKKKKKMMYLTTRNAEFDRHE-------IQIYEEVAKMPPFQRKTLVLI 344
Query: 721 GPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHK 777
G + + + I P +FG+ VP T+R R+ E DG+ Y FV SR +ME DI+ K
Sbjct: 345 GAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFV-SRSEMEADIKAGK 403
Query: 778 FIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMEN 837
++E G+Y +LYGT + S+ EV + G+ CILDV+ A+K L+ ++ P +FI +E
Sbjct: 404 YLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELET 463
Query: 838 IMEMNKR----------LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQI 887
+ M+K LT+ +KT + + ++++ + +F I+ D L+ + +++
Sbjct: 464 LRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTA 523
Query: 888 IEEQSGSYIWVP 899
IE+ WVP
Sbjct: 524 IEKLRMEPQWVP 535
Score = 31.6 bits (70), Expect = 3.5
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 5/60 (8%)
Query: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTH--EEAVTALKNTSDFVYLKV 402
+N + + +I+ GG + G L +GD + VN EV + +E LKN S V LK+
Sbjct: 149 NNDLVIARILHGGMIDRQGLLHVGDIIKEVNG---HEVGNNPKELQELLKNISGSVTLKI 205
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 151 bits (381), Expect = 3e-36
Identities = 105/421 (24%), Positives = 201/421 (47%), Gaps = 31/421 (7%)
Query: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT--IVAQYRPE 548
++ I+ GG G L GD I +N + + + EQ L+ ++T IV YR +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 549 EYSRFEAKIHDLREQMMNSSISSGSG-----SLRTSQKRSLYVRALFDYDKTKDSGLPSQ 603
S R+ N S+ + S + R +YVRA F+YD KD +P +
Sbjct: 575 SSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCK 634
Query: 604 --GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFN 661
G+ F+ GDI+ +I+ D WWQ + + ++ G+IPS E R+ +
Sbjct: 635 EAGIRFRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEW----RVACIAME 688
Query: 662 SKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILG 721
+++ G K ++ + + +++YE V + + +++LG
Sbjct: 689 KTKQEQQASCTWFGKKKKQYKDKYLAKHNAD-------LVTYEEVVKLPAFKRKTLVLLG 741
Query: 722 PM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
+ I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +DI +++
Sbjct: 742 AHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEY 800
Query: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
+E G + + +YGT ++++R++ E+G ILDV A+K L+ A+ P +FI ++
Sbjct: 801 LEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPG 860
Query: 839 MEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV 898
+ ++ L Q L++ + +F + + +++ +++ +E + WV
Sbjct: 861 LNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWV 915
Query: 899 P 899
P
Sbjct: 916 P 916
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/98 (21%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP 405
N V +I+ GG H+ G L +GD++ +N + + T E+ L+ + K+ P
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIV-P 569
Query: 406 TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
+ + + S P + H S ++ + P++
Sbjct: 570 SYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPST 607
Score = 30.8 bits (68), Expect = 5.9
Identities = 42/187 (22%), Positives = 72/187 (38%), Gaps = 24/187 (12%)
Query: 122 SPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPV 181
SPQI N + V +++ L EI + + K + +L P + ++ V
Sbjct: 395 SPQIRNPP--SDAVQRAKEVLEEIS------CYPENNDAKELKRILTQPHFMALLQTHDV 446
Query: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGG 241
A V + PPP T Y+NG + ++ +E
Sbjct: 447 VAHE-VYSDEALRVTPPP---------TSPYLNGDSPESANGDMDMENVTRVRLVQFQKN 496
Query: 242 TDNP-----HIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL 296
TD P + + + + +I+ GG + G L V D I +N + V + T + + L
Sbjct: 497 TDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKML 556
Query: 297 KE-AGSI 302
+E GSI
Sbjct: 557 REMRGSI 563
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 150 bits (379), Expect = 5e-36
Identities = 164/685 (23%), Positives = 273/685 (39%), Gaps = 125/685 (18%)
Query: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
S IF+ +I AA+DG ++ D +L++N +++ + A ++ + +++ V+R
Sbjct: 204 SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 263
Query: 311 KPVS-------------------EKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350
+ + + I EI+ L G P S
Sbjct: 264 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPS 323
Query: 351 TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM 410
+G L+ D+ E ++ AV+ +D K + ++
Sbjct: 324 DHSRHSPQQPSNGSLRSRDE---------ERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
Query: 411 NDGYAP------PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREP 464
N+ P P VD VSPS G P S +D I R
Sbjct: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSD--GVLPNSTH-----------EDGILRPS 421
Query: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
K+V R +G + GG D GIF++ +L PA G L +GD+I+ VN+VD
Sbjct: 422 MKLVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 525 HEQAAAALKNA--GQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKR 582
E+A L + G+ VTI+AQ + + Y R + S G
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRI---------------VESDVGD------- 517
Query: 583 SLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEVG 639
S Y+R F+Y+K GL+F G++ V++ + W A ++ + + E G
Sbjct: 518 SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERG 572
Query: 640 VIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQ--E 697
+IP+K R E+ L +V++ G+ D +GL+ N S Q +
Sbjct: 573 IIPNKNRAEQ-----LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQ 627
Query: 698 EYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDG 757
+YE V +E + RPV I GP+ D + L E PD + RD D
Sbjct: 628 TKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIAKSEPRDAGTDQ 683
Query: 758 RDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKR 817
R + + +++++ ++ KH +LDV+ NA+ R
Sbjct: 684 RSSGII----------------------------RLHTIKQIIDQDKHALLDVTPNAVDR 715
Query: 818 LQIAQLYPISIFIKPKSMENIMEMNKRLTEE---QARKTFERAMKLEQEFTEHFTAIVQG 874
L AQ YPI +F+ P S + + M RL E ARK +ER+ KL + FT +
Sbjct: 716 LNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINL 775
Query: 875 DTLED-IYNQVKQIIEEQSGSYIWV 898
+++ D Y +K+ I++Q +WV
Sbjct: 776 NSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 65.1 bits (157), Expect = 3e-10
Identities = 36/98 (36%), Positives = 61/98 (62%), Gaps = 4/98 (4%)
Query: 218 ADYEYEEITLERGNS-GLGFSIAGGTDNPHI-GDDSSIFITKIITGGAAAQDGRLRVNDC 275
A +E +TL R G G +I+GG DNPH ++SI I+ ++ GG A +G+L+ ND
Sbjct: 17 AIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDR 74
Query: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
+ VN V + +V H+ AV+ L+++G ++ ++R+K V
Sbjct: 75 VAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 22/234 (9%)
Query: 328 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V ++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP---------------VDNHV 431
AV L+ + + + + + + P+ + + + V N
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 432 SPSSFLGQTPASPAR-YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIF 490
S + AS R SP S +P KV L + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
+ I A G +++GD ++ +N S A ++ + + +V Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 47.0 bits (110), Expect = 8e-05
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 451 SKAVLGDDEITREPRKVVLHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 502
+K+ ++ E V LHR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 503 SGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI-----------VAQYRPE--- 548
G+L++ DR+ VN V + H A L+ +G+ I V++ PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 549 --EYSRFEAKIHDLR 561
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 150 bits (379), Expect = 5e-36
Identities = 164/685 (23%), Positives = 273/685 (39%), Gaps = 125/685 (18%)
Query: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
S IF+ +I AA+DG ++ D +L++N +++ + A ++ + +++ V+R
Sbjct: 204 SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 263
Query: 311 KPVS-------------------EKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350
+ + + I EI+ L G P S
Sbjct: 264 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPS 323
Query: 351 TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM 410
+G L+ D+ E ++ AV+ +D K + ++
Sbjct: 324 DHSRHSPQQPSNGSLRSRDE---------ERISKPGAVSTPVKHADDHTPKTVEEVTVER 374
Query: 411 NDGYAP------PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREP 464
N+ P P VD VSPS G P S +D I R
Sbjct: 375 NEKQTPSLPEPKPVYAQVGQPDVDLPVSPSD--GVLPNSTH-----------EDGILRPS 421
Query: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
K+V R +G + GG D GIF++ +L PA G L +GD+I+ VN+VD
Sbjct: 422 MKLVKFRKGDSVGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 525 HEQAAAALKNA--GQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKR 582
E+A L + G+ VTI+AQ + + Y R + S G
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRI---------------VESDVGD------- 517
Query: 583 SLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEW---WQARQVTPDGESDEVG 639
S Y+R F+Y+K GL+F G++ V++ + W A ++ + + E G
Sbjct: 518 SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERG 572
Query: 640 VIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQ--E 697
+IP+K R E+ L +V++ G+ D +GL+ N S Q +
Sbjct: 573 IIPNKNRAEQ-----LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQ 627
Query: 698 EYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDG 757
+YE V +E + RPV I GP+ D + L E PD + RD D
Sbjct: 628 TKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIAKSEPRDAGTDQ 683
Query: 758 RDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKR 817
R + + +++++ ++ KH +LDV+ NA+ R
Sbjct: 684 RSSGII----------------------------RLHTIKQIIDQDKHALLDVTPNAVDR 715
Query: 818 LQIAQLYPISIFIKPKSMENIMEMNKRLTEE---QARKTFERAMKLEQEFTEHFTAIVQG 874
L AQ YPI +F+ P S + + M RL E ARK +ER+ KL + FT +
Sbjct: 716 LNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINL 775
Query: 875 DTLED-IYNQVKQIIEEQSGSYIWV 898
+++ D Y +K+ I++Q +WV
Sbjct: 776 NSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 65.1 bits (157), Expect = 3e-10
Identities = 36/98 (36%), Positives = 61/98 (62%), Gaps = 4/98 (4%)
Query: 218 ADYEYEEITLERGNS-GLGFSIAGGTDNPHI-GDDSSIFITKIITGGAAAQDGRLRVNDC 275
A +E +TL R G G +I+GG DNPH ++SI I+ ++ GG A +G+L+ ND
Sbjct: 17 AIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDR 74
Query: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
+ VN V + +V H+ AV+ L+++G ++ ++R+K V
Sbjct: 75 VAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 22/234 (9%)
Query: 328 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V ++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP---------------VDNHV 431
AV L+ + + + + + + P+ + + + V N
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 432 SPSSFLGQTPASPAR-YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIF 490
S + AS R SP S +P KV L + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
+ I A G +++GD ++ +N S A ++ + + +V Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 47.0 bits (110), Expect = 8e-05
Identities = 42/135 (31%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 451 SKAVLGDDEITREPRKVVLHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 502
+K+ ++ E V LHR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 503 SGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI-----------VAQYRPE--- 548
G+L++ DR+ VN V + H A L+ +G+ I V++ PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 549 --EYSRFEAKIHDLR 561
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 149 bits (377), Expect = 9e-36
Identities = 118/468 (25%), Positives = 212/468 (45%), Gaps = 70/468 (14%)
Query: 441 PASPARYS--PVSKA-VLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
P SPA+ V K ++ +++T EP + L + + ++ IL G
Sbjct: 55 PGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLN------------EKQSCTVARILHG 102
Query: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
G G L GD I+ +N ++ S +Q A+K +++ + P + SR A
Sbjct: 103 GMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQSRLPA-- 158
Query: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHV 615
+++RA FDYD KD+ +P + GL F GDI+ +
Sbjct: 159 ------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQI 194
Query: 616 INASDDEWWQARQVTPDGESDE-VGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDM 674
IN D WWQ R +G S E G+IPS E + + ++ E P
Sbjct: 195 INKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA--------PSEAPSCS 243
Query: 675 GSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPM---KDRINDDL 731
K SS Q + V+SYE V + + ++++G + I + L
Sbjct: 244 PFGKKKKYKDKYLAKHSSIFDQLD-VVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
Query: 732 ISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGT 791
+S+ P+KF VP+TTRP R E DG++YHF+ S E+M ++I ++F+E G Y +++GT
Sbjct: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFI-STEEMTRNISANEFLEFGSYQGNMFGT 361
Query: 792 SVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQAR 851
++V ++ ++ K ILD+ +K ++ A+L P +FI P E ++L ++
Sbjct: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
Query: 852 KTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVP 899
+ + ++ +F + + +++ ++++ ++ S WVP
Sbjct: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
Score = 40.8 bits (94), Expect = 0.006
Identities = 18/56 (32%), Positives = 31/56 (55%)
Query: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
S V +I+ GG H+ G L +GD++L +N + + ++ A+K T + LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 36.2 bits (82), Expect = 0.14
Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 12/129 (9%)
Query: 247 IGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLY 306
+ + S + +I+ GG + G L V D IL +N +V + + + +A+KE ++ L
Sbjct: 88 LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
Query: 307 V----KRRKPVSEKIMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKII 354
V + R P + M + P K G A G Q I D+S + +
Sbjct: 148 VIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRV 207
Query: 355 EGGAAHKDG 363
EG + G
Sbjct: 208 EGSSKESAG 216
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 147 bits (372), Expect = 3e-35
Identities = 107/416 (25%), Positives = 197/416 (47%), Gaps = 39/416 (9%)
Query: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT--IVAQYRPE 548
++ I+ GG G L GD I +N + + + EQ L+ ++T IV YR +
Sbjct: 509 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 568
Query: 549 EYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLN 606
SS S + R +YVRA F+YD KD +P + G+
Sbjct: 569 ------------------SSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIR 610
Query: 607 FKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRD 666
F+ GDI+ +I+ D WWQ + + ++ G+IPS E R+ + KT+
Sbjct: 611 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEW----RVACIAME-KTKQ 663
Query: 667 KGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPM--- 723
+ + K K ++ Q + V +YE V + + +++LG
Sbjct: 664 EQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLV-TYEEVVKLPAFKRKTLVLLGAHGVG 722
Query: 724 KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQ 783
+ I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +DI ++++E G
Sbjct: 723 RRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGS 781
Query: 784 YNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNK 843
+ + +YGT ++++R++ E+G ILDV A+K L+ A+ P +FI ++ + ++
Sbjct: 782 HEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDE 841
Query: 844 RLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVP 899
L Q L++ + +F + + +++ +++ +E + WVP
Sbjct: 842 SLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 892
Score = 35.8 bits (81), Expect = 0.18
Identities = 15/57 (26%), Positives = 28/57 (49%)
Query: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
N V +I+ GG H+ G L +GD++ +N + + T E+ L+ + K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561
Score = 34.3 bits (77), Expect = 0.54
Identities = 47/213 (22%), Positives = 80/213 (37%), Gaps = 24/213 (11%)
Query: 122 SPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPV 181
SPQI N + V +++ L EI + + K + +L P + ++ V
Sbjct: 389 SPQIRNPP--SDAVQRAKEVLEEIS------CYPENNDAKELKRILTQPHFMALLQTHDV 440
Query: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGG 241
A V + PPP T Y+NG + ++ +E
Sbjct: 441 VAHE-VYSDEALRVTPPP---------TSPYLNGDSPESANGDMDMENVTRVRLVQFQKN 490
Query: 242 TDNP-----HIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL 296
TD P + + + + +I+ GG + G L V D I +N + V + T + + L
Sbjct: 491 TDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKML 550
Query: 297 KE-AGSIVRLYVKRRKPVSEKIMEIKLIKGPKG 328
+E GSI V + S ++ PKG
Sbjct: 551 REMRGSITFKIVPSYRTQSSSCEDLPSTTQPKG 583
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 146 bits (368), Expect = 1e-34
Identities = 103/416 (24%), Positives = 196/416 (47%), Gaps = 44/416 (10%)
Query: 491 ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT--IVAQYRPE 548
++ I+ GG G L GD I +N + + + EQ L+ ++T IV YR +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 549 EYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLN 606
SS S + R +YVRA F+YD KD +P + G+
Sbjct: 575 ------------------SSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIR 616
Query: 607 FKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRD 666
F+ GDI+ +I+ D WWQ + + ++ G+IPS E R+ + ++
Sbjct: 617 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEW----RVACIAMEKTKQE 670
Query: 667 KGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPM--- 723
+ G K ++ + + +++YE V + + +++LG
Sbjct: 671 QQASCTWFGKKKKQYKDKYLAKHNAD-------LVTYEEVVKLPAFKRKTLVLLGAHGVG 723
Query: 724 KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQ 783
+ I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +DI ++++E G
Sbjct: 724 RRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGS 782
Query: 784 YNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNK 843
+ + +YGT ++++R++ E+G ILDV A+K L+ A+ P +FI ++ + ++
Sbjct: 783 HEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDE 842
Query: 844 RLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVP 899
L Q L++ + +F + + +++ +++ +E + WVP
Sbjct: 843 SLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 893
Score = 35.8 bits (81), Expect = 0.18
Identities = 15/57 (26%), Positives = 28/57 (49%)
Query: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
N V +I+ GG H+ G L +GD++ +N + + T E+ L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
Score = 34.3 bits (77), Expect = 0.54
Identities = 47/213 (22%), Positives = 80/213 (37%), Gaps = 24/213 (11%)
Query: 122 SPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPV 181
SPQI N + V +++ L EI + + K + +L P + ++ V
Sbjct: 395 SPQIRNPP--SDAVQRAKEVLEEIS------CYPENNDAKELKRILTQPHFMALLQTHDV 446
Query: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGG 241
A V + PPP T Y+NG + ++ +E
Sbjct: 447 VAHE-VYSDEALRVTPPP---------TSPYLNGDSPESANGDMDMENVTRVRLVQFQKN 496
Query: 242 TDNP-----HIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL 296
TD P + + + + +I+ GG + G L V D I +N + V + T + + L
Sbjct: 497 TDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKML 556
Query: 297 KE-AGSIVRLYVKRRKPVSEKIMEIKLIKGPKG 328
+E GSI V + S ++ PKG
Sbjct: 557 REMRGSITFKIVPSYRTQSSSCEDLPSTTQPKG 589
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 139 bits (350), Expect = 1e-32
Identities = 110/326 (33%), Positives = 158/326 (48%), Gaps = 28/326 (8%)
Query: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
I + +G SGLG SI GG D P ++I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
Query: 285 RDVTHSKAVEALKEAGSIVRLYVKR-----RKPVSEKIMEIKL-IKGPKGLGFSIAGGVG 338
R+ +H +A+ AL++ VRL V R R + +I + L K +GLG SI G
Sbjct: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK-- 1551
Query: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
+ ++++ I++GGAA DG+L GD++L+VN + + E T LK V
Sbjct: 1552 ----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
Query: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPS---SFLG-QTPASPARYSPVSKAV 454
L++ + + + S Q + PS G Q R S S+
Sbjct: 1608 QLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKN 1667
Query: 455 LGDDEITREPRKVVLHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKG 509
G D EPR V ++R S LG +I GG +FI+ I A G A + +L+ G
Sbjct: 1668 SGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
Query: 510 DRIISVNSVDLRAASHEQAAAALKNA 535
DRI+S+N L SH LKNA
Sbjct: 1725 DRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 109 bits (272), Expect = 1e-23
Identities = 92/352 (26%), Positives = 158/352 (44%), Gaps = 70/352 (19%)
Query: 221 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRV 279
+ E I +ER ++G LGFS+ + ++G IF+ + G A +D RL+ ND IL +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
Query: 280 NEVDV-RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK--------------------IM 318
N + ++++H +A+ L++ +RL V R +PV K +
Sbjct: 189 NHTPLDQNISHQQAIALLQQTTGSLRLIVAR-EPVHTKSSTSSSLNDTTLPETVCWGHVE 247
Query: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
E++LI GLGF I GG + + V I+ GG A +DG+LQ GD +L +
Sbjct: 248 EVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 379 LEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLG 438
++ +T E+ L+N + V + VA+ P+ +
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVAR---------------------------DPAGDIS 333
Query: 439 QTPASPARY-----SPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG----GEDGE-- 487
TP +PA + SK D + ++ + LG IVG GE
Sbjct: 334 VTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEAS 393
Query: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
GI++ I+ G A +G ++ D+I++V+ V+++ ++ L+NAGQ V
Sbjct: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
Score = 108 bits (271), Expect = 2e-23
Identities = 81/224 (36%), Positives = 105/224 (46%), Gaps = 52/224 (23%)
Query: 312 PVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
P E I+EI KG GLG SI GG N+I + ++ E GAA +DG+L GD++
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 372 LAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHV 431
L VN V L +HEEA+TAL+ T V L V + + Y D N PVD
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYR-------DEENLEIFPVD--- 1535
Query: 432 SPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFI 491
+ + GLG +IVG +G G+FI
Sbjct: 1536 ------------------------------------LQKKAGRGLGLSIVGKRNGSGVFI 1559
Query: 492 SFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA 535
S I+ GG ADL G L +GD+I+SVN D+R AS E A LK A
Sbjct: 1560 SDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
Score = 85.5 bits (210), Expect = 2e-16
Identities = 83/295 (28%), Positives = 119/295 (40%), Gaps = 62/295 (21%)
Query: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
I+L K GLG S+AG + SI+V I G A DG+++IGD+LL +NN L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 380 EEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSS---------SQPVDNH 430
+H+ A +K V L + P + +SS ++P+ +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 431 VSPSSFLG--QTPASPARYSPVS---------KAVLGDDEITREPRK------------- 466
S +G Q P S + VS K EI P
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 467 ----------------------VVLHRGSTGLGFNIVGGEDG--EGIFISFILAGGPADL 502
+ + +G +GLG +IVGG+D I I + G A
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAAR 1475
Query: 503 SGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
G L GD+I+ VN VDLR +SHE+A AL+ Q V +V YR E + R E +
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENL 1529
Score = 82.8 bits (203), Expect = 1e-15
Identities = 62/221 (28%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE-VTHEE 386
GLGFS+ + +Q++ G I+V + G A +D +L+ D++LA+N+ L++ ++H++
Sbjct: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 387 AVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPAR 446
A+ L+ T+ + L VA+ +PV S SS L T
Sbjct: 202 AIALLQQTTGSLRLIVAR--------------------EPVHTKSSTSSSLNDT------ 235
Query: 447 YSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
L + +V L +GLGF IVGG+ G+ + I+ GG AD G L
Sbjct: 236 -------TLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRL 287
Query: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
+ GD I+ + +++ + EQ A L+N G +V ++ P
Sbjct: 288 QTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 81.6 bits (200), Expect = 3e-15
Identities = 88/363 (24%), Positives = 137/363 (37%), Gaps = 65/363 (17%)
Query: 180 PVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIA 239
P PA V LPT+ P +DS TY E+ + G S LG I
Sbjct: 337 PAPAALPVALPTVASKGP-----GSDSSLFETY---------NVELVRKDGQS-LGIRIV 381
Query: 240 GGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
G H G+ S I++ II G AA +G ++VND I+ V+ V+++ + VE L+ A
Sbjct: 382 GYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNA 441
Query: 300 GSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 359
G +V L + RRK S P D V +
Sbjct: 442 GQVVHLTLVRRKTSS---------------------STSPLEPPSDRGTVVEPL------ 474
Query: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
K L + + NV E+ +E + LKN + K+ K P
Sbjct: 475 -KPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEK----------VPDSP 523
Query: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFN 479
N +N + P + + + D E+ + + + +H G+ +
Sbjct: 524 ENELKSRWENLLGPD--------YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVD 575
Query: 480 IVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
G +IS I++GGP D G L+ D ++ VN + L S +A + LK
Sbjct: 576 SFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPF 631
Query: 540 TIV 542
T+V
Sbjct: 632 TLV 634
Score = 80.1 bits (196), Expect = 9e-15
Identities = 67/255 (26%), Positives = 110/255 (43%), Gaps = 38/255 (14%)
Query: 320 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
+++ + P LG SI GG + + G I++ +++E A K L+ GDK+
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 372 LAVNNVCLEEVTHEEAVTALKNTSD---FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
L V+ V L+ +H EAV A+KN + F+ ++ + N IT + +Q D
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQ--D 1183
Query: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDD-------------------EITREPRKVVL 469
G P P + P KA+ D ++ E + L
Sbjct: 1184 TQEKKEKRQGTAP-PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
Query: 470 HRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQ 527
+ GLG ++ G +D IF+ I GPA G +R GD ++ +N+ L SH+
Sbjct: 1243 EKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
Query: 528 AAAALKNAGQAVTIV 542
A+A +K A V +V
Sbjct: 1303 ASAIIKTAPSKVKLV 1317
Score = 72.8 bits (177), Expect = 1e-12
Identities = 61/235 (25%), Positives = 98/235 (41%), Gaps = 62/235 (26%)
Query: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
++ GLG SI G + S +FI+ I+ GGAA DGRL D IL VN D+R+
Sbjct: 1538 KKAGRGLGLSIVGKRNG------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 288 THSKAVEALKEAGSIVRLYVKRRKPVS--------------------------------- 314
+ LK A +V+L + R + S
Sbjct: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 315 EKIMEIKLIKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 353
+ ++ K + P LG SIAGG G+ GD +++ I
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
Query: 354 IEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSM 408
G A + KL++GD+++++N L+ ++H + V LKN + L+V T++
Sbjct: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
Score = 63.2 bits (152), Expect = 1e-09
Identities = 38/96 (39%), Positives = 52/96 (54%), Gaps = 18/96 (18%)
Query: 459 EITREPRKVVLHRGSTGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRK 508
EI REP + LG +IVGG E+ +GIFI +L PA + L+
Sbjct: 1070 EIFREP--------NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKT 1121
Query: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
GD+I+ V+ VDL+ ASH +A A+KNAG V + Q
Sbjct: 1122 GDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 60.5 bits (145), Expect = 7e-09
Identities = 79/354 (22%), Positives = 128/354 (36%), Gaps = 101/354 (28%)
Query: 147 NVHGFVSHSHISPIKPTEAVLP-----SPPTVPVIPVLPVPAENTVILPTIPQANPPPVL 201
N+ GF +H + ++ V+ + P+ P TV+ P PP L
Sbjct: 425 NIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPL-----KPPAL 479
Query: 202 VNTDSLETPTYVNGTDADYEYEEITLERGNS-------------------------GLGF 236
T ++ET T V+G D + + TL+ N G +
Sbjct: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
Query: 237 SIAGGTDNPHIGDDSSI-------------------------FITKIITGGAAAQDGRLR 271
+ T + I DD+ + +I+ I++GG G L+
Sbjct: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQ 599
Query: 272 VNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRK-----------------PVS 314
D +L VN + + + +AV LKE L RR P +
Sbjct: 600 PEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPET 659
Query: 315 E----------------------KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK 352
E ++ ++L+K KGLGFSI + P + I +
Sbjct: 660 EVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD-YQDPLDPTRSVIVIRS 718
Query: 353 IIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT-SDFVYLKVAKP 405
++ G A + G L GD+L++VN CL+ + EAV LK V+L + KP
Sbjct: 719 LVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 51.6 bits (122), Expect = 3e-06
Identities = 62/247 (25%), Positives = 100/247 (40%), Gaps = 42/247 (17%)
Query: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK 404
D Y++ I+ GG G LQ D+LL VN + L + EAV+ LK L +
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
Query: 405 PTSMYMNDGYAPPDITNSSSQP---VDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEIT 461
++ ++ +S P VD+++ ++ A +SP
Sbjct: 638 --RLFDDEASVDEPRRTETSLPETEVDHNMDVNTE-EDDDGELALWSP------------ 682
Query: 462 REPRKVVLHRGSTGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDRIISVN 516
E + V L + GLGF+I+ +D I I ++A G A+ SG L GDR++SVN
Sbjct: 683 -EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 517 SVDLRAASHEQAAAALK------------------NAGQAVTIVAQYRPEEYSRFEAKIH 558
L S +A LK N ++ I+ E+ + F IH
Sbjct: 742 EYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIH 801
Query: 559 DLREQMM 565
D+ ++
Sbjct: 802 DINSSLI 808
Score = 47.8 bits (112), Expect = 5e-05
Identities = 30/82 (36%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 231 NSGLGFSIAGGTD---NPHIGDD-SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
N LG SI GG G++ IFI +++ A + L+ D IL V+ VD+++
Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
Query: 287 VTHSKAVEALKEAGSIVRLYVK 308
+HS+AVEA+K AG+ V V+
Sbjct: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 138 bits (347), Expect = 3e-32
Identities = 109/369 (29%), Positives = 173/369 (46%), Gaps = 63/369 (17%)
Query: 208 ETPTYVNGT----DADYEYEEI----TLE---RGNSGLGFSIAGGTDNPHIGDDSSIFIT 256
+TP V T +A Y+ EE+ T+E + GLG SI G + D+ +F++
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN------DTGVFVS 1752
Query: 257 KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV--------- 307
I+ GG A DGRL D IL VN DVR+ T LK + + +
Sbjct: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS 1812
Query: 308 ------KRRKPVSEKIMEIKLIKGPKG----LGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357
++ ++ +I ++ ++ KG LG SIAGGVG+ GD I++ + G
Sbjct: 1813 ESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTG 1870
Query: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417
A + KL++GD+++ + E +TH +AV LKN S + ++V + +
Sbjct: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSV------- 1923
Query: 418 DITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLG 477
+T +P + +S F G T S ++ DD + + + L RG GLG
Sbjct: 1924 -VTGHQQEPASSSLS---FTGLT----------SSSIFQDDLGPPQCKSITLERGPDGLG 1969
Query: 478 FNIVGGEDGEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
F+IVGG I++ + A G A G L++GD+II+VN L +HE+A A LK
Sbjct: 1970 FSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029
Query: 534 NAGQAVTIV 542
VT++
Sbjct: 2030 RTKGTVTLM 2038
Score = 116 bits (291), Expect = 8e-26
Identities = 101/326 (30%), Positives = 154/326 (47%), Gaps = 55/326 (16%)
Query: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
I + +G +GLG SI GG+D +I I ++ GAA +DGRL D IL VN +D+
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
Query: 285 RDVTHSKAVEALKEAGSIVRLYVKR-RKPVSEK----IMEIKLIKGP-KGLGFSIAGGVG 338
R TH +A+ L++ VRL + R P E+ + I+L K P KGLG SI G
Sbjct: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
Query: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
D ++V+ I++GG A DG+L GD++L VN + T +EAV AL S+
Sbjct: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEAVAALLKVSEGS 1798
Query: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDD 458
P S +S+S+ ++ S ++ + ++ + G
Sbjct: 1799 LSSFTFPLS------------GSSTSESLE--------------SSSKKNALASEIQG-- 1830
Query: 459 EITREPRKVVLHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDRII 513
R V + +G T LG +I GG IFI+ + G A + +LR GDRI+
Sbjct: 1831 -----LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIV 1885
Query: 514 SVNSVDLRAASHEQAAAALKNAGQAV 539
++ +H QA LKNA ++
Sbjct: 1886 TICGTSTEGMTHTQAVNLLKNASGSI 1911
Score = 115 bits (287), Expect = 2e-25
Identities = 138/637 (21%), Positives = 252/637 (39%), Gaps = 114/637 (17%)
Query: 7 DTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66
D RALH E ++KL + D + + ++ QS LF ++ +Q V L +
Sbjct: 6 DKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQT--SVQQLKDQVN 63
Query: 67 IDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS------------------PSVEKY 108
I S S I+ + +S T+ +E+ S + P+ +++
Sbjct: 64 IATSATSN-IEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEF 122
Query: 109 RYQDEDTPPQEHISP----QITNEVIGPELVHVSEKNLSEI-----ENVHGFVSHSHISP 159
++ H+ + + +G +V + +N E+ E G V+H
Sbjct: 123 DQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD-GR 181
Query: 160 IKPTEAVLP-----------SPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLE 208
+K T+ +L + ++ + + ++PQ P V + +
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAS 241
Query: 209 TPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG 268
T + + E I L SGLGF I GG + + + I+ GG A Q G
Sbjct: 242 TISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKA-------TGVIVKTILPGGVADQHG 294
Query: 269 RLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR------------------- 309
RL D IL++ + D+ ++ + + L++ G+ V+L + R
Sbjct: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSS 354
Query: 310 -------------RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 356
+K + +++L K +GLG +IAG +G++ + + I+V I +
Sbjct: 355 PTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKS 413
Query: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
A DG++QIGD+++AV+ L+ T+++AV L++T V L + + + +
Sbjct: 414 SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSR 473
Query: 417 PDITNSSS-QPV------DNHVSPSSFLGQT------PASPARYSPVSKAVLGDDEITRE 463
D+T + PV +N+ FL T P Y P+ A + + E ++
Sbjct: 474 EDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGY-PLLSAEIEEIEDAQK 532
Query: 464 PRKVVLHRGSTGLGFNI---------VGGEDGEGI---------FISFILAGGPADLSGE 505
+L + +G N G GI FI +L GP SG+
Sbjct: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGK 592
Query: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIV 542
L GD ++ VN + L +H+ LK VT+V
Sbjct: 593 LFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 112 bits (281), Expect = 1e-24
Identities = 82/232 (35%), Positives = 117/232 (50%), Gaps = 37/232 (15%)
Query: 204 TDSLETPTYVNGTDADYE-YEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261
++SLE+ + N ++ + + +++G LG SIAGG +P +GD IFI +
Sbjct: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGD-VPIFIAMMHPT 1869
Query: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV-----------KRR 310
G AAQ +LRV D I+ + +TH++AV LK A + + V ++
Sbjct: 1870 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
Query: 311 KPVSEKIM--------------------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350
+P S + I L +GP GLGFSI GG G+ H GD IYV
Sbjct: 1930 EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYV 1987
Query: 351 TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
+ GAA +DG+L+ GD+++AVN LE VTHEEAV LK T V L V
Sbjct: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 112 bits (280), Expect = 2e-24
Identities = 108/382 (28%), Positives = 166/382 (43%), Gaps = 62/382 (16%)
Query: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
E I LE+G+SGLG S+AG D + S+FI I GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
Query: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP----------------------VSEKIM 318
+ +H A +K A S V++ R K + K
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 319 EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGK 364
E + + S V + +P D + + + + E G A DG+
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 365 LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV--AKPTSMYMND--GYAPPDIT 420
L++GD++LAV++ + E+ ++ LK V L + P S + G A +
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
Query: 421 NSSSQ---PVDNHVSPSSFLGQTPAS-PARYS--PVSKAVLGDDEITREPRKVVLHRGST 474
NSS P P S + +S PA ++ P + ++ E T E + +G T
Sbjct: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIE-----ISKGRT 1637
Query: 475 GLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
GLG +IVGG D I I + G A G L GD+I+ VN +DLR A+H++A L
Sbjct: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
Query: 533 KNAGQAVTIV-----AQYRPEE 549
+ Q V + A Y+ EE
Sbjct: 1698 RQTPQRVRLTLYRDEAPYKEEE 1719
Score = 102 bits (253), Expect = 2e-21
Identities = 106/420 (25%), Positives = 181/420 (43%), Gaps = 88/420 (20%)
Query: 181 VPAENTVILPTIPQAN--PPPVLVNTDSLETP--TYVNGTDADYEYEEIT---------- 226
VP + ++PT+ + P N ++L P ++NG A E++++
Sbjct: 77 VPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVE 136
Query: 227 ----LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282
L+ + GLGFS+ G + IF+ +I G A +DGRL+ D IL +N
Sbjct: 137 VFELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
Query: 283 DV-RDVTHSKAVEALKEAGSIVRLYVKR------------------------RKPVSEKI 317
+ + +TH +A+ L++A V+L + R PV +
Sbjct: 195 ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
Query: 318 ME-IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376
ME I+L+ GLGF I GG + V I+ GG A + G+L GD +L + +
Sbjct: 255 METIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGD 307
Query: 377 VCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF 436
L ++ E+ L+ + V L +A+ ++ +P++
Sbjct: 308 TDLAGMSSEQVAQVLRQCGNRVKLMIARGA--------------------IEERTAPTA- 346
Query: 437 LGQTPASPARYSPVSKAVLGDDEITREPRK-----VVLHRGSTGLGFNIVG--GE---DG 486
LG T +S SP S L D T++ + V L + GLG I G G+ +
Sbjct: 347 LGITLSS----SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEP 402
Query: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546
GIF+ I + G ++ GD+II+V+ +L+ +++QA L++ GQ V + R
Sbjct: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
Score = 90.1 bits (222), Expect = 8e-18
Identities = 97/426 (22%), Positives = 171/426 (40%), Gaps = 114/426 (26%)
Query: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
I + +GNS LG +++ D + + II GGA ++DGR+ + DCIL +NE
Sbjct: 1009 INIAKGNSSLGMTVSANKDG------LGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 285 RDVTHSKAVEALK----------------------------EAGSIVRL-----YVKRRK 311
VT+++A L+ ++G ++ L Y R
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 312 PVSEKIME---------------------IKLIKGP-KGLGFSIAGG--VGNQHIPGD-- 345
P + E ++L + P K LG SI GG +G++ G+
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
Query: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK- 404
I++ ++E A K+G L+ GD+++ V+ + L + +HE+AV A++ + V V
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
Query: 405 -------PTSMYMNDGYAPPDIT-----------NSSSQPVDNHVSPSS--FLGQTPASP 444
P +++ Y + + N+ P + P P P
Sbjct: 1243 INRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPP 1302
Query: 445 ARY------------SPVSKAVLGDDE--------------ITREPRKVVLHRGSTGLGF 478
+ + S +S+ V +DE +T E + L +G +GLG
Sbjct: 1303 SAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGL 1362
Query: 479 NIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
++ G +D +FI I G A G L+ D ++ +N L SH+ A++ +K A
Sbjct: 1363 SLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAP 1422
Query: 537 QAVTIV 542
V I+
Sbjct: 1423 SKVKII 1428
Score = 86.7 bits (213), Expect = 9e-17
Identities = 85/290 (29%), Positives = 137/290 (47%), Gaps = 43/290 (14%)
Query: 320 IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376
I + KG LG +++ G+G + V II GGA +DG++ IGD +L++N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 377 VCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
VT+ +A L+ S +K+ + ++ + + +D SS
Sbjct: 1060 ESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF---SS 1116
Query: 436 FLGQT-PASPARYSPVSKAVLGDDEITR-------EPRKVVLHRG-STGLGFNIVGGE-- 484
+ G+ P P R + + E+ +PR+V L R S LG +IVGG
Sbjct: 1117 YTGRDIPELPEREEGEGE----ESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGM 1172
Query: 485 -----DGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
+GE GIFI +L PA +G L+ GDRI+ V+ +DLR ASHEQA A++ AG
Sbjct: 1173 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAG 1232
Query: 537 QAVTIVAQ---YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583
V + Q RP + S + +H+L + SS + + SL+ + ++
Sbjct: 1233 NPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
Score = 75.1 bits (183), Expect = 3e-13
Identities = 101/406 (24%), Positives = 168/406 (41%), Gaps = 74/406 (18%)
Query: 199 PVLVNTDSLETPTYVNGTDADYE--YEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256
PVL TD+ ++ V A +E + I LE+G+ GLGFSI D P + I I
Sbjct: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
Query: 257 KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGS-IVRLYVKRRKPVSE 315
++ GG A +DGRL D ++ VN+V++ + + +AVEALK A S VR+ V + P+S
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Query: 316 K----------------------IMEIKLIKGPKGL-GFSIAGGVG-----NQHIPGDNS 347
+ + + L + L G + A V + + P ++S
Sbjct: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDS 851
Query: 348 IYVTK---IIEGGAAHKDGKLQIGDKLLA------VNNVC---------LEEVTHEEAVT 389
IY T+ + G++ DG L G L + + N C LEE+ + +
Sbjct: 852 IYSTQASILSLHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQ 910
Query: 390 ALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSP 449
+ V + + + +ND Y P + + + V S L S A
Sbjct: 911 RQDENTPSVDISMGPASGFTIND-YTPANAIEQQYECENTIVWTESHLPSEVISSAELPS 969
Query: 450 V--------SKAVLGDDEITREPRKVVLH--------------RGSTGLGFNIVGGEDGE 487
V S+ +L + V+L +G++ LG + +DG
Sbjct: 970 VLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL 1029
Query: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
G+ + I+ GG G + GD I+S+N + ++ QA A L+
Sbjct: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 71.6 bits (174), Expect = 3e-12
Identities = 68/240 (28%), Positives = 101/240 (42%), Gaps = 37/240 (15%)
Query: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387
GLG S+ VG+ ++ ++ G GKL GD+LL VN + L H++
Sbjct: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
Query: 388 VTALKNTSDFVYL----KVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
V LK V + + PT+ D DI + VD LG+ S
Sbjct: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVD--------LGEFIGS 667
Query: 444 PARYSPVSKAVLGDDEITREPRK-----------VVLHRGSTGLGFNIVGGED-----GE 487
PV A+ + T E + + L +GS GLGF+I+ +D
Sbjct: 668 SETEDPVL-AMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726
Query: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
I I ++ GG A+ G L GDR++ VN V+L +S E+A ALK A + +P
Sbjct: 727 VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
Score = 63.5 bits (153), Expect = 8e-10
Identities = 62/256 (24%), Positives = 106/256 (41%), Gaps = 22/256 (8%)
Query: 290 SKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIY 349
S+ V+ E G + +R ++ ++ I+L KG GLG S+AG + S++
Sbjct: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM----SVF 1376
Query: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK----P 405
+ I GAA KDG+LQI D+LL +N L +H+ A + +K V + +
Sbjct: 1377 IVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
Query: 406 TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPR 465
M + G A + ++S + P+ + + V L D+
Sbjct: 1437 NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQ------ 1490
Query: 466 KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
GLG I + G+ I + G A G L+ GD+I++V+ +
Sbjct: 1491 --------GGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
Query: 526 EQAAAALKNAGQAVTI 541
E+ + LK A V +
Sbjct: 1543 EKFISLLKTAKMTVKL 1558
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 203 NTDSLETPTYVNGTDADYEY------EEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256
N + ET V +DA + + + L + GLG +I+ S + I
Sbjct: 1456 NLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL------SGVIIK 1509
Query: 257 KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK 316
+ G AA DGRL+V D IL V++ V K + LK A V+L + P S+
Sbjct: 1510 SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQA 1569
Query: 317 I 317
+
Sbjct: 1570 V 1570
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 137 bits (346), Expect = 3e-32
Identities = 153/642 (23%), Positives = 255/642 (39%), Gaps = 160/642 (24%)
Query: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP 405
+ I++ I + G A + LQ GD +L +N V + ++ + ++ + + L V +
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
Query: 406 TSMYMNDGYAPPDITNSSSQPVDNHV-------SP-------SSFLGQTPAS----PARY 447
++ + PP +++S S P++ V SP +S L Q P S P R+
Sbjct: 291 RGQFLVN--IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRH 348
Query: 448 SPVSKAVLGDDEITREPR------------------------------------------ 465
+ S D PR
Sbjct: 349 AQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
Query: 466 ------KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519
+VV +G + GG D GIF+S + AG PAD G +++GD+I+ VN V
Sbjct: 409 GYSPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
Query: 520 LRAASHEQAAAALKNA--GQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR 577
+ + E+A L G+ + +V Q + D+ +M+ S +
Sbjct: 467 FQNLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGD------ 509
Query: 578 TSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---------SDDEWWQARQ 628
S Y+R F+ + + P GL F GD+ HV++ + W A +
Sbjct: 510 -----SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVR 559
Query: 629 VTPDGESDEVGVIPSKRRVEK------KERARLKTVKFNSKTRDKGEIPDDMG-SKGLKH 681
+ D E G+IP++ R E+ +RA ++ + + E G +G K
Sbjct: 560 MGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKK 619
Query: 682 VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKF-- 739
T + + S+ Q Y YE V +E ++ RPV+ILGP+ D L +E PD+F
Sbjct: 620 TTQRSREDLSALTRQGRYP-PYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEI 678
Query: 740 GSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREV 799
V T P + ++D +VR +
Sbjct: 679 AETVSRTDSPSKIIKLD--------------------------------------TVRVI 700
Query: 800 AEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRL---TEEQARKTFER 856
AEK KH +LDV+ +AI+RL Q YPI +F P+S + + + L + R+ + +
Sbjct: 701 AEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQ 760
Query: 857 AMKLEQEFTEHFTAIVQ-GDTLEDIYNQVKQIIEEQSGSYIW 897
A KL + + FTA + T + Y ++K II EQ IW
Sbjct: 761 AQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/95 (30%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 220 YEYEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
+E TL + G G +I+GG D P S+ ++ ++ GG A +GRL+ D I+
Sbjct: 26 WEQHTATLSKDPRRGFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVM 79
Query: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
VN V + + T + A++ LK + + VKR + +
Sbjct: 80 VNGVSMENATSAFAIQILKTCTKMANITVKRPRRI 114
Score = 47.8 bits (112), Expect = 5e-05
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 322 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
L K P+ G G +I+GG + PG S+ V+ ++ GG A +G+LQ GD ++ VN V +E
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
Query: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417
T A+ LK + + V +P +++ A P
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASP 123
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/72 (36%), Positives = 40/72 (55%), Gaps = 9/72 (12%)
Query: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
++ +KG K +G +AGG D I+V+ + G A G +Q GD++L VN+V
Sbjct: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
Query: 380 EEVTHEEAVTAL 391
+ +T EEAV L
Sbjct: 468 QNLTREEAVQFL 479
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 133 bits (334), Expect = 9e-31
Identities = 155/664 (23%), Positives = 276/664 (41%), Gaps = 119/664 (17%)
Query: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
S IF+ ++ G A +DG L D IL++N +++ + A + ++++ ++L V R
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH--KDGKLQIG 368
+ ++ I + D+ I IE + ++ + Q
Sbjct: 385 S--QQTLINIPSLND------------------SDSEIEDISEIESNRSFSPEERRHQYS 424
Query: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
D ++ L+E ++ ++T + A PT A + ++ +P
Sbjct: 425 DYDYHSSSEKLKE-----RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRY 479
Query: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG 488
P+ P + R SP +A+ G + K+V + +G + GG D G
Sbjct: 480 QEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT------KMVRFKKGDSVGLRLAGGND-VG 532
Query: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
IF++ I G A+ G L++GD+I+ VN+ D R E A L G+ VTI+AQ R
Sbjct: 533 IFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
Query: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLN 606
+ Y ++ G G S ++R+ F+ +K Q L
Sbjct: 592 ADVY---------------RDILACGRGD-------SFFIRSHFECEKETP-----QSLA 624
Query: 607 FKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663
F G++ V++ D W A ++ G E G+IP+K R E+ + N++
Sbjct: 625 FTRGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQ 675
Query: 664 TRDKGEIPDDMGSKGL-----KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVI 718
+ G+ D +G K++ + D + ++ +YE V +E + RPV+
Sbjct: 676 RDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFP-AYERVLLREAGFKRPVV 734
Query: 719 ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
+ GP+ D + L +E PD F + T P KD K
Sbjct: 735 LFGPIADIAMEKLANELPDWFQTA---KTEP---------------------KDAGSEKS 770
Query: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
+ N +VR++ E+ KH +LDV+ A+ L Q +PI IF P S + +
Sbjct: 771 TGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV 821
Query: 839 MEMNKRL---TEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDI-YNQVKQIIEEQSGS 894
M +RL + + +RK F++A KL++ FTA + ++ D + +K I+ Q G
Sbjct: 822 KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGE 881
Query: 895 YIWV 898
+WV
Sbjct: 882 AVWV 885
Score = 67.4 bits (163), Expect = 6e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 4/96 (4%)
Query: 220 YEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DSSIFITKIITGGAAAQDGRLRVNDCIL 277
+E +TL++ + G G +++GG DNPH + ++SI I+ ++ GG A DG L+ ND ++
Sbjct: 29 WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVV 86
Query: 278 RVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
VN + DV HS AV+ L+++G + + VKR + V
Sbjct: 87 MVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Query: 327 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHE 385
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 386 EAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
AV L+ + + V +P + + A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 48.1 bits (113), Expect = 4e-05
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 11/102 (10%)
Query: 456 GDDEITREPRKVVLHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 507
G +E+ E V L + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 508 KGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEE 549
+ DR++ VN + H A L+ +G+ IV + RP +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
Score = 37.0 bits (84), Expect = 0.083
Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 285 RDVTHSKAVEALKE--AGSIVRLYVKRRKPVSEKIM 318
R + AV L E G +V + + R V I+
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 133 bits (334), Expect = 9e-31
Identities = 155/664 (23%), Positives = 276/664 (41%), Gaps = 119/664 (17%)
Query: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
S IF+ ++ G A +DG L D IL++N +++ + A + ++++ ++L V R
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH--KDGKLQIG 368
+ ++ I + D+ I IE + ++ + Q
Sbjct: 385 S--QQTLINIPSLND------------------SDSEIEDISEIESNRSFSPEERRHQYS 424
Query: 369 DKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
D ++ L+E ++ ++T + A PT A + ++ +P
Sbjct: 425 DYDYHSSSEKLKE-----RPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRY 479
Query: 429 NHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG 488
P+ P + R SP +A+ G + K+V + +G + GG D G
Sbjct: 480 QEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT------KMVRFKKGDSVGLRLAGGND-VG 532
Query: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
IF++ I G A+ G L++GD+I+ VN+ D R E A L G+ VTI+AQ R
Sbjct: 533 IFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
Query: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLN 606
+ Y ++ G G S ++R+ F+ +K Q L
Sbjct: 592 ADVY---------------RDILACGRGD-------SFFIRSHFECEKETP-----QSLA 624
Query: 607 FKFGDILHVINASDDEW---WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663
F G++ V++ D W A ++ G E G+IP+K R E+ + N++
Sbjct: 625 FTRGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQ 675
Query: 664 TRDKGEIPDDMGSKGL-----KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVI 718
+ G+ D +G K++ + D + ++ +YE V +E + RPV+
Sbjct: 676 RDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFP-AYERVLLREAGFKRPVV 734
Query: 719 ILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
+ GP+ D + L +E PD F + T P KD K
Sbjct: 735 LFGPIADIAMEKLANELPDWFQTA---KTEP---------------------KDAGSEKS 770
Query: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
+ N +VR++ E+ KH +LDV+ A+ L Q +PI IF P S + +
Sbjct: 771 TGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV 821
Query: 839 MEMNKRL---TEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDI-YNQVKQIIEEQSGS 894
M +RL + + +RK F++A KL++ FTA + ++ D + +K I+ Q G
Sbjct: 822 KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGE 881
Query: 895 YIWV 898
+WV
Sbjct: 882 AVWV 885
Score = 67.4 bits (163), Expect = 6e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 4/96 (4%)
Query: 220 YEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DSSIFITKIITGGAAAQDGRLRVNDCIL 277
+E +TL++ + G G +++GG DNPH + ++SI I+ ++ GG A DG L+ ND ++
Sbjct: 29 WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVV 86
Query: 278 RVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
VN + DV HS AV+ L+++G + + VKR + V
Sbjct: 87 MVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Query: 327 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHE 385
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 386 EAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
AV L+ + + V +P + + A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 48.1 bits (113), Expect = 4e-05
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 11/102 (10%)
Query: 456 GDDEITREPRKVVLHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 507
G +E+ E V L + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 508 KGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEE 549
+ DR++ VN + H A L+ +G+ IV + RP +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK-RPRK 121
Score = 37.0 bits (84), Expect = 0.083
Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 285 RDVTHSKAVEALKE--AGSIVRLYVKRRKPVSEKIM 318
R + AV L E G +V + + R V I+
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,478,189
Number of Sequences: 37866
Number of extensions: 1765731
Number of successful extensions: 7191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 5496
Number of HSP's gapped (non-prelim): 1379
length of query: 904
length of database: 18,247,518
effective HSP length: 111
effective length of query: 793
effective length of database: 14,044,392
effective search space: 11137202856
effective search space used: 11137202856
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.