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Search of human proteins with 148536853
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
(1224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 2501 0.0
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 2493 0.0
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 274 4e-73
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 111 4e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 110 1e-23
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 110 1e-23
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 110 1e-23
gi|113865883 WD repeat domain 38 [Homo sapiens] 106 1e-22
gi|16554629 WD repeat domain 5 [Homo sapiens] 106 2e-22
gi|16554627 WD repeat domain 5 [Homo sapiens] 106 2e-22
gi|26665869 WD repeat domain 51B [Homo sapiens] 103 8e-22
gi|23199987 WD repeat domain 5B [Homo sapiens] 102 2e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 102 3e-21
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 100 8e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 97 9e-20
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 97 9e-20
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 97 9e-20
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 95 5e-19
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 95 5e-19
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 95 5e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 94 6e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 94 6e-19
gi|21071067 TBP-associated factor 5 [Homo sapiens] 93 1e-18
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 89 2e-17
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 88 6e-17
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 87 7e-17
gi|18874090 WD repeat domain 48 [Homo sapiens] 86 2e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 85 4e-16
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 82 4e-15
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 82 4e-15
>gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo
sapiens]
Length = 1224
Score = 2501 bits (6481), Expect = 0.0
Identities = 1224/1224 (100%), Positives = 1224/1224 (100%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH
Sbjct: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
Query: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 181 VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW 240
VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW
Sbjct: 181 VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW 240
Query: 241 EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH 300
EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH
Sbjct: 241 EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH 300
Query: 301 PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG 360
PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG
Sbjct: 301 PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG 360
Query: 361 SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW 420
SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW
Sbjct: 361 SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW 420
Query: 421 VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK 480
VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK
Sbjct: 421 VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK 480
Query: 481 RTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGV 540
RTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGV
Sbjct: 481 RTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGV 540
Query: 541 FIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFK 600
FIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFK
Sbjct: 541 FIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFK 600
Query: 601 LALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEI 660
LALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEI
Sbjct: 601 LALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEI 660
Query: 661 ALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMM 720
ALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMM
Sbjct: 661 ALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMM 720
Query: 721 KIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDP 780
KIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDP
Sbjct: 721 KIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDP 780
Query: 781 EKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTV 840
EKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTV
Sbjct: 781 EKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTV 840
Query: 841 GTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAG 900
GTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAG
Sbjct: 841 GTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAG 900
Query: 901 GAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFL 960
GAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFL
Sbjct: 901 GAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFL 960
Query: 961 QTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVG 1020
QTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVG
Sbjct: 961 QTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVG 1020
Query: 1021 KFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQ 1080
KFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQ
Sbjct: 1021 KFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQ 1080
Query: 1081 QKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQ 1140
QKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQ
Sbjct: 1081 QKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQ 1140
Query: 1141 TRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQI 1200
TRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQI
Sbjct: 1141 TRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQI 1200
Query: 1201 CRVTTVTEIGKDVIGLRISPLQFR 1224
CRVTTVTEIGKDVIGLRISPLQFR
Sbjct: 1201 CRVTTVTEIGKDVIGLRISPLQFR 1224
>gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo
sapiens]
Length = 1233
Score = 2493 bits (6461), Expect = 0.0
Identities = 1224/1233 (99%), Positives = 1224/1233 (99%), Gaps = 9/1233 (0%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH
Sbjct: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
Query: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 181 VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW 240
VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW
Sbjct: 181 VRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAW 240
Query: 241 EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH 300
EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH
Sbjct: 241 EVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAH 300
Query: 301 PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG 360
PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG
Sbjct: 301 PNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSG 360
Query: 361 SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW 420
SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW
Sbjct: 361 SKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVW 420
Query: 421 VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK 480
VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK
Sbjct: 421 VARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQK 480
Query: 481 RTLASVKISKVKYVIWSADMSHVALLAKH---------AIVICNRKLDALCNIHENIRVK 531
RTLASVKISKVKYVIWSADMSHVALLAKH AIVICNRKLDALCNIHENIRVK
Sbjct: 481 RTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVK 540
Query: 532 SGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLT 591
SGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLT
Sbjct: 541 SGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLT 600
Query: 592 IDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSL 651
IDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSL
Sbjct: 601 IDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSL 660
Query: 652 ALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITG 711
ALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITG
Sbjct: 661 ALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITG 720
Query: 712 NLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEA 771
NLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEA
Sbjct: 721 NLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEA 780
Query: 772 ESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGAL 831
ESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGAL
Sbjct: 781 ESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGAL 840
Query: 832 AADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPE 891
AADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPE
Sbjct: 841 AADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPE 900
Query: 892 LDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQ 951
LDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQ
Sbjct: 901 LDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQ 960
Query: 952 FGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQ 1011
FGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQ
Sbjct: 961 FGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQ 1020
Query: 1012 LCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERK 1071
LCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERK
Sbjct: 1021 LCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERK 1080
Query: 1072 KLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLEL 1131
KLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLEL
Sbjct: 1081 KLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLEL 1140
Query: 1132 GPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGAC 1191
GPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGAC
Sbjct: 1141 GPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGAC 1200
Query: 1192 YSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR 1224
YSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR
Sbjct: 1201 YSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR 1233
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 274 bits (700), Expect = 4e-73
Identities = 218/805 (27%), Positives = 362/805 (44%), Gaps = 96/805 (11%)
Query: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
K +S RVK + HP PW+L SL+NG + +W++ TL+ F+ D PVR F ++
Sbjct: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
Query: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
V+G DD +I+V+NY + H DYIR H P+IL++SDD I++W+W
Sbjct: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
Query: 124 SR-TCVCVLTGHNHYVMCAQFHPTED-LVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
+ +C V GH HYVM +P ++ SASLD+T++VW + + SP
Sbjct: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLG-----SSSPN------ 178
Query: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP--TMPLIVSGADDRQVKIWRMNESKA 239
LEGH++GVN ++ P ++SGADDR VKIW
Sbjct: 179 -----------------FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221
Query: 240 WEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA 299
V T GH NVSCA FHP +I++ SED ++R+W S T +R W +A+
Sbjct: 222 --VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVAS 279
Query: 300 HPNLNLFAAGHDGGMIVFKLERERPAYAVHGN-MLHYVKDRFLRQLDFNSSKDVAVMQLR 358
N A G+D G I+ KL RE PA ++ N + + K ++Q + + D +++
Sbjct: 280 LRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDA---EIK 336
Query: 359 SGSKFPVF------------NMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPD 406
G + P+ + +NP V++C + Y +YT +
Sbjct: 337 DGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVC------GDGEYIIYTAMALRNKSFGS 390
Query: 407 APEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLL 466
A E W A + R + ++K KN KK P+ G L +
Sbjct: 391 AQE--------FAW-AHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGV 441
Query: 467 RDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVI---CNRKLDALCN 523
R + + +D + ++I + K++ WS V + + + I + K+ A
Sbjct: 442 RSVNGLAFYDWDNTELIRRIEI-QPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQE 500
Query: 524 IHENIR-----------------VKSGAWDESGVFIYTTS-NHIKYAVTTGDHGIIRTLD 565
HE + VK+G W FIYT+S N + Y V G+ I LD
Sbjct: 501 THEGVTEDGIEDAFEVLGEIQEIVKTGLW-VGDCFIYTSSVNRLNYYV-GGEIVTIAHLD 558
Query: 566 LPIYVTRV--KGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKY---DEVLHMVRNAKL 620
+Y+ K N +Y D+E ++ + +++ A++ R + D+VL + K
Sbjct: 559 RTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPTI--PKE 616
Query: 621 VGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEV 680
+ +L+K+G+ + AL D + RF LAL+ G ++IA + A + + W++L E+
Sbjct: 617 QRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAEL 676
Query: 681 ALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLG 740
A+ + + + C +++ L L +GN + K+ + AE + + + G
Sbjct: 677 AISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQG 736
Query: 741 DVSERVRILKNCGQKSLAYLTAATH 765
V + +L G+ A A T+
Sbjct: 737 KVDACLELLIRTGRLPEAAFLARTY 761
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 111 bits (278), Expect = 4e-24
Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 36/295 (12%)
Query: 17 FHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
FHP ++++ + I++WDY H V+ I F L S D IK
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNH 136
+W+++ C+ T+ GH + + I+SAS D+TI++W Q+ CV TGH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 137 YVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKK-------------NLSPGAVESDVRG 183
+V + + L+ S S DQTVRVW ++ K + +P + S +
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 184 ITGVD-----------LFGTTDAVVK----------HVLEGHDRGVNWAAFHPTMPLIVS 222
TG + L G+ D +K L GHD V FH I+S
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 223 GADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
ADD+ +++W + + T H + V+ FH +++ S D++++VW+
Sbjct: 356 CADDKTLRVWDYKNKRC--MKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 110 bits (274), Expect = 1e-23
Identities = 75/279 (26%), Positives = 126/279 (45%), Gaps = 37/279 (13%)
Query: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
H PV + FH + VS +D IKVW+Y+ TL GH D ++ F H +
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI----- 164
S S D TI++W++Q C+ + GH+H V P D +VSAS D+T+++W++
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 165 ----SGLRK-----KNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
+G R+ + G + + V ++ K L H+ V ++ P
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286
Query: 216 TM--------------------PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCA 255
P ++SG+ D+ +K+W ++ + T GH N V
Sbjct: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC--LMTLVGHDNWVRGV 344
Query: 256 VFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRF 294
+FH + ILS ++DK++RVWD + ++T H+ F
Sbjct: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA-HEHF 382
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/192 (27%), Positives = 82/192 (42%), Gaps = 34/192 (17%)
Query: 87 FTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPT 146
+ L GH + FH + ++SAS+D TI+VW++++ L GH V F +
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 147 EDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDR 206
L+ S S D T+++WD G + GHD
Sbjct: 162 GKLLASCSADMTIKLWDFQGFE----------------------------CIRTMHGHDH 193
Query: 207 GVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQE--LI 264
V+ A P IVS + D+ +K+W + + V T GH V + P Q+ LI
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEV--QTGYCVKTFTGHREWV--RMVRPNQDGTLI 249
Query: 265 LSNSEDKSIRVW 276
S S D+++RVW
Sbjct: 250 ASCSNDQTVRVW 261
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/145 (25%), Positives = 55/145 (37%), Gaps = 42/145 (28%)
Query: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNES-------------------- 237
K+ L GH V FHP ++VS ++D +K+W
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 238 --------------KAWE------VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
K W+ + T GH +NVS P + I+S S DK+I++W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 278 MSKRTGVQTFRRDHDRFWVLAAHPN 302
+ V+TF R WV PN
Sbjct: 221 VQTGYCVKTF--TGHREWVRMVRPN 243
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 110 bits (274), Expect = 1e-23
Identities = 68/273 (24%), Positives = 119/273 (43%), Gaps = 30/273 (10%)
Query: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
+F V ++F P + + + +++W + F H VR + F
Sbjct: 18 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77
Query: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
FV+ DD +KVW ++ LF+L H++++R F + I+SASDD+T+++W+
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 124 SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRG 183
SR CV H +V FHP+ + +A +D TV+VWD+
Sbjct: 138 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV------------------- 178
Query: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVD 243
T +++H + H VN +FHP+ +++ + D +KI + E + +
Sbjct: 179 --------RTHRLLQH-YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL--LY 227
Query: 244 TCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW 276
T GH + F E S D+ + VW
Sbjct: 228 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 81.3 bits (199), Expect = 5e-15
Identities = 64/234 (27%), Positives = 104/234 (44%), Gaps = 19/234 (8%)
Query: 114 DQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLS 173
D + VW+ + ++ TGH V C F P+ L+ S S D+TVR+W + ++ ++
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
Query: 174 PGAVESDVRGI----TGVDLFGTTDAVVKHVLEGH--------DRGVNW---AAFHPTMP 218
A + VR + G +D V H + +NW A F P
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 219 LIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
LIVS +DD+ VK+W ++S V + H V+ FHP I + D +++VWD+
Sbjct: 121 LIVSASDDKTVKLW--DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 279 SKRTGVQTFRRDHDRFWVLAAHPNLN-LFAAGHDGGMIVFKLERERPAYAVHGN 331
+Q ++ L+ HP+ N L A D + + L R Y +HG+
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232
Score = 78.2 bits (191), Expect = 5e-14
Identities = 52/233 (22%), Positives = 92/233 (39%), Gaps = 28/233 (12%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
T F +A V+ + F +T+ + +++W + +H VR F
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 63 QPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNW 122
L VS DD +K+W+ R C+ + H ++ FH I +A D T++VW+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 123 QSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVR 182
++ + H+ V FHP+ + +++AS D T+++ D+
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL------------------ 220
Query: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
+ + + L GH AF T SG D QV +W+ N
Sbjct: 221 ----------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 52.4 bits (124), Expect = 3e-06
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
+L ++ SA V GLSFHP +++T+ + +++ D L+ H GP + F
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Query: 61 KQQPLFVSGGDDYKIKVW 78
+ F SGG D ++ VW
Sbjct: 243 RTGEYFASGGSDEQVMVW 260
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 110 bits (274), Expect = 1e-23
Identities = 68/273 (24%), Positives = 119/273 (43%), Gaps = 30/273 (10%)
Query: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
+F V ++F P + + + +++W + F H VR + F
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
FV+ DD +KVW ++ LF+L H++++R F + I+SASDD+T+++W+
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 124 SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRG 183
SR CV H +V FHP+ + +A +D TV+VWD+
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV------------------- 216
Query: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVD 243
T +++H + H VN +FHP+ +++ + D +KI + E + +
Sbjct: 217 --------RTHRLLQH-YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL--LY 265
Query: 244 TCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW 276
T GH + F E S D+ + VW
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 87.8 bits (216), Expect = 6e-17
Identities = 70/257 (27%), Positives = 112/257 (43%), Gaps = 19/257 (7%)
Query: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV 150
GH D + F + S S D + VW+ + ++ TGH V C F P+ L+
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 151 VSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI----TGVDLFGTTDAVVKHVLEGH-- 204
S S D+TVR+W + ++ ++ A + VR + G +D V H
Sbjct: 77 ASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 205 ------DRGVNW---AAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCA 255
+ +NW A F P LIVS +DD+ VK+W ++S V + H V+
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW--DKSSRECVHSYCEHGGFVTYV 193
Query: 256 VFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN-LFAAGHDGGM 314
FHP I + D +++VWD+ +Q ++ L+ HP+ N L A D +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 315 IVFKLERERPAYAVHGN 331
+ L R Y +HG+
Sbjct: 254 KILDLMEGRLLYTLHGH 270
Score = 78.2 bits (191), Expect = 5e-14
Identities = 52/233 (22%), Positives = 92/233 (39%), Gaps = 28/233 (12%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
T F +A V+ + F +T+ + +++W + +H VR F
Sbjct: 97 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 156
Query: 63 QPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNW 122
L VS DD +K+W+ R C+ + H ++ FH I +A D T++VW+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Query: 123 QSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVR 182
++ + H+ V FHP+ + +++AS D T+++ D+
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL------------------ 258
Query: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
+ + + L GH AF T SG D QV +W+ N
Sbjct: 259 ----------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 52.4 bits (124), Expect = 3e-06
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
+L ++ SA V GLSFHP +++T+ + +++ D L+ H GP + F
Sbjct: 221 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 280
Query: 61 KQQPLFVSGGDDYKIKVW 78
+ F SGG D ++ VW
Sbjct: 281 RTGEYFASGGSDEQVMVW 298
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 4/84 (4%)
Query: 194 DAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN-ESKAWEVDTCRGHYNNV 252
D ++ +GH V F + SG+ D + +W M +S+A+ GH + V
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF---TGHKDAV 64
Query: 253 SCAVFHPRQELILSNSEDKSIRVW 276
+C F P L+ S S DK++R+W
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIW 88
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 110 bits (274), Expect = 1e-23
Identities = 68/273 (24%), Positives = 119/273 (43%), Gaps = 30/273 (10%)
Query: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
+F V ++F P + + + +++W + F H VR + F
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
FV+ DD +KVW ++ LF+L H++++R F + I+SASDD+T+++W+
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 124 SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRG 183
SR CV H +V FHP+ + +A +D TV+VWD+
Sbjct: 176 SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV------------------- 216
Query: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVD 243
T +++H + H VN +FHP+ +++ + D +KI + E + +
Sbjct: 217 --------RTHRLLQH-YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL--LY 265
Query: 244 TCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW 276
T GH + F E S D+ + VW
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 87.8 bits (216), Expect = 6e-17
Identities = 70/257 (27%), Positives = 112/257 (43%), Gaps = 19/257 (7%)
Query: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV 150
GH D + F + S S D + VW+ + ++ TGH V C F P+ L+
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 151 VSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI----TGVDLFGTTDAVVKHVLEGH-- 204
S S D+TVR+W + ++ ++ A + VR + G +D V H
Sbjct: 77 ASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 205 ------DRGVNW---AAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCA 255
+ +NW A F P LIVS +DD+ VK+W ++S V + H V+
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW--DKSSRECVHSYCEHGGFVTYV 193
Query: 256 VFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN-LFAAGHDGGM 314
FHP I + D +++VWD+ +Q ++ L+ HP+ N L A D +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 315 IVFKLERERPAYAVHGN 331
+ L R Y +HG+
Sbjct: 254 KILDLMEGRLLYTLHGH 270
Score = 78.2 bits (191), Expect = 5e-14
Identities = 52/233 (22%), Positives = 92/233 (39%), Gaps = 28/233 (12%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
T F +A V+ + F +T+ + +++W + +H VR F
Sbjct: 97 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 156
Query: 63 QPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNW 122
L VS DD +K+W+ R C+ + H ++ FH I +A D T++VW+
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Query: 123 QSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVR 182
++ + H+ V FHP+ + +++AS D T+++ D+
Sbjct: 217 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL------------------ 258
Query: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
+ + + L GH AF T SG D QV +W+ N
Sbjct: 259 ----------MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 52.4 bits (124), Expect = 3e-06
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
+L ++ SA V GLSFHP +++T+ + +++ D L+ H GP + F
Sbjct: 221 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 280
Query: 61 KQQPLFVSGGDDYKIKVW 78
+ F SGG D ++ VW
Sbjct: 281 RTGEYFASGGSDEQVMVW 298
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 4/84 (4%)
Query: 194 DAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN-ESKAWEVDTCRGHYNNV 252
D ++ +GH V F + SG+ D + +W M +S+A+ GH + V
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF---TGHKDAV 64
Query: 253 SCAVFHPRQELILSNSEDKSIRVW 276
+C F P L+ S S DK++R+W
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIW 88
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 106 bits (265), Expect = 1e-22
Identities = 72/305 (23%), Positives = 125/305 (40%), Gaps = 28/305 (9%)
Query: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
F V +F P +LT +G + W+ R L+ + H GPV+ F
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
LF S D +++W+ +CL L GH + T F + + S D+ + +W+ QS
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI 184
+ +L GH + + F PT + + + S D TV +WD+ +
Sbjct: 137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV----------------- 179
Query: 185 TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDT 244
T AV LEGH ++ + + L+ SG+ D+ + IW+ S +
Sbjct: 180 --------TPAVSHQALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSL--LIQ 228
Query: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN 304
+GH V F P + + S + ++VWD + ++T + D A P+
Sbjct: 229 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK 288
Query: 305 LFAAG 309
+ +G
Sbjct: 289 ILVSG 293
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/151 (24%), Positives = 62/151 (41%), Gaps = 2/151 (1%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDF--HKQQPLFVSG 69
++ F P + T + + +WD RM T +G I + L SG
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
Query: 70 GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC 129
D I +W L L GH+ ++++ F + W+ SA + ++VW+ + C+
Sbjct: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
Query: 130 VLTGHNHYVMCAQFHPTEDLVVSASLDQTVR 160
L G F P ++VS + DQT R
Sbjct: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 106 bits (264), Expect = 2e-22
Identities = 70/300 (23%), Positives = 129/300 (43%), Gaps = 32/300 (10%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
V + F P W+ +S + +I++W H + + + L VS D
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 72 DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL 131
D +K+W+ +CL TL GH +Y+ F+ + I+S S D+++R+W+ ++ C+ L
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 132 TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFG 191
H+ V F+ L+VS+S D R+WD +
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-------------------------- 201
Query: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
+ +K +++ + V++ F P I++ D +K+W ++ K + T GH N
Sbjct: 202 -SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC--LKTYTGHKNE 258
Query: 252 VSCAVFH---PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
C + + I+S SED + +W++ + VQ + D A HP N+ A+
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/212 (27%), Positives = 91/212 (42%), Gaps = 33/212 (15%)
Query: 79 NYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYV 138
NY L+ FTL GH + + F W+ S+S D+ I++W ++GH +
Sbjct: 34 NYALK---FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90
Query: 139 MCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVK 198
+ +L+VSAS D+T+++WD+S
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVS----------------------------SGKCL 122
Query: 199 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 258
L+GH V F+P LIVSG+ D V+IW + K + T H + VS F+
Sbjct: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFN 180
Query: 259 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRD 290
LI+S+S D R+WD + ++T D
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212
Score = 79.7 bits (195), Expect = 2e-14
Identities = 47/160 (29%), Positives = 83/160 (51%), Gaps = 12/160 (7%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYR----MCTLIDKFDEHDGPVRGIDFHKQQPLFV 67
V + F+ I++S ++G+ ++WD + TLID + + PV + F +
Sbjct: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID---DDNPPVSFVKFSPNGKYIL 230
Query: 68 SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP---WILSASDDQTIRVWNWQS 124
+ D +K+W+Y +CL T GH + F + WI+S S+D + +WN Q+
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASL--DQTVRVW 162
+ V L GH V+ HPTE+++ SA+L D+T+++W
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 79.3 bits (194), Expect = 2e-14
Identities = 52/186 (27%), Positives = 83/186 (44%), Gaps = 39/186 (20%)
Query: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLF 190
L GH V +F P + + S+S D+ +++W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW---------------------------- 72
Query: 191 GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYN 250
G D + + GH G++ A+ L+VS +DD+ +KIW ++ K + T +GH N
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSN 130
Query: 251 NVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGH 310
V C F+P+ LI+S S D+S+R+WD+ ++T D V A H N
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP--VSAVHFN-------R 181
Query: 311 DGGMIV 316
DG +IV
Sbjct: 182 DGSLIV 187
Score = 75.1 bits (183), Expect = 4e-13
Identities = 58/225 (25%), Positives = 101/225 (44%), Gaps = 36/225 (16%)
Query: 16 SFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
+F+P+ I++ + +++WD + + H PV + F++ L VS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 76 KVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTG 133
++W+ +CL TL+ D +F F +IL+A+ D T+++W++ C+ TG
Sbjct: 196 RIWDTASGQCLKTLIDD-DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 134 HNH--YVMCAQFHPT-EDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLF 190
H + Y + A F T +VS S D V +W++
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ------------------------- 289
Query: 191 GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA--DDRQVKIWR 233
T + V K L+GH V A HPT +I S A +D+ +K+W+
Sbjct: 290 -TKEIVQK--LQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 2/113 (1%)
Query: 197 VKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAV 256
+K L GH + V+ F P + S + D+ +KIW + K + T GH +S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVA 94
Query: 257 FHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAG 309
+ L++S S+DK++++WD+S ++T + + + +P NL +G
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
T + + V + F P +IL + + ++LWDY + + H I +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 63 QP---LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS--DDQTI 117
VSG +D + +WN + + + L GH D + +T H I SA+ +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
Query: 118 RVW 120
++W
Sbjct: 328 KLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 106 bits (264), Expect = 2e-22
Identities = 70/300 (23%), Positives = 129/300 (43%), Gaps = 32/300 (10%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
V + F P W+ +S + +I++W H + + + L VS D
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 72 DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL 131
D +K+W+ +CL TL GH +Y+ F+ + I+S S D+++R+W+ ++ C+ L
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 132 TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFG 191
H+ V F+ L+VS+S D R+WD +
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-------------------------- 201
Query: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
+ +K +++ + V++ F P I++ D +K+W ++ K + T GH N
Sbjct: 202 -SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC--LKTYTGHKNE 258
Query: 252 VSCAVFH---PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
C + + I+S SED + +W++ + VQ + D A HP N+ A+
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/212 (27%), Positives = 91/212 (42%), Gaps = 33/212 (15%)
Query: 79 NYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYV 138
NY L+ FTL GH + + F W+ S+S D+ I++W ++GH +
Sbjct: 34 NYALK---FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90
Query: 139 MCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVK 198
+ +L+VSAS D+T+++WD+S
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVS----------------------------SGKCL 122
Query: 199 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 258
L+GH V F+P LIVSG+ D V+IW + K + T H + VS F+
Sbjct: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFN 180
Query: 259 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRD 290
LI+S+S D R+WD + ++T D
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212
Score = 79.7 bits (195), Expect = 2e-14
Identities = 47/160 (29%), Positives = 83/160 (51%), Gaps = 12/160 (7%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYR----MCTLIDKFDEHDGPVRGIDFHKQQPLFV 67
V + F+ I++S ++G+ ++WD + TLID + + PV + F +
Sbjct: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID---DDNPPVSFVKFSPNGKYIL 230
Query: 68 SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP---WILSASDDQTIRVWNWQS 124
+ D +K+W+Y +CL T GH + F + WI+S S+D + +WN Q+
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASL--DQTVRVW 162
+ V L GH V+ HPTE+++ SA+L D+T+++W
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 79.3 bits (194), Expect = 2e-14
Identities = 52/186 (27%), Positives = 83/186 (44%), Gaps = 39/186 (20%)
Query: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLF 190
L GH V +F P + + S+S D+ +++W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW---------------------------- 72
Query: 191 GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYN 250
G D + + GH G++ A+ L+VS +DD+ +KIW ++ K + T +GH N
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSN 130
Query: 251 NVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGH 310
V C F+P+ LI+S S D+S+R+WD+ ++T D V A H N
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP--VSAVHFN-------R 181
Query: 311 DGGMIV 316
DG +IV
Sbjct: 182 DGSLIV 187
Score = 75.1 bits (183), Expect = 4e-13
Identities = 58/225 (25%), Positives = 101/225 (44%), Gaps = 36/225 (16%)
Query: 16 SFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
+F+P+ I++ + +++WD + + H PV + F++ L VS D
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 76 KVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTG 133
++W+ +CL TL+ D +F F +IL+A+ D T+++W++ C+ TG
Sbjct: 196 RIWDTASGQCLKTLIDD-DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 134 HNH--YVMCAQFHPT-EDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLF 190
H + Y + A F T +VS S D V +W++
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ------------------------- 289
Query: 191 GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA--DDRQVKIWR 233
T + V K L+GH V A HPT +I S A +D+ +K+W+
Sbjct: 290 -TKEIVQK--LQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 2/113 (1%)
Query: 197 VKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAV 256
+K L GH + V+ F P + S + D+ +KIW + K + T GH +S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVA 94
Query: 257 FHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAG 309
+ L++S S+DK++++WD+S ++T + + + +P NL +G
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
T + + V + F P +IL + + ++LWDY + + H I +
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267
Query: 63 QP---LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS--DDQTI 117
VSG +D + +WN + + + L GH D + +T H I SA+ +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
Query: 118 RVW 120
++W
Sbjct: 328 KLW 330
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 103 bits (258), Expect = 8e-22
Identities = 65/265 (24%), Positives = 116/265 (43%), Gaps = 30/265 (11%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
V + F P + ++ + ++LW +F H PVR +DF + +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 72 DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL 131
D IKVW+ +R L++L H ++R F + I+S S+D+TI++W+ ++ CV
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Query: 132 TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFG 191
+ + F+P+ + SA DQTV+VWD+
Sbjct: 183 SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV--------------------------- 215
Query: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
+ +++H + H GVN +FHP+ +++ + D +KI + E + + T +GH
Sbjct: 216 RVNKLLQH-YQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRL--IYTLQGHTGP 272
Query: 252 VSCAVFHPRQELILSNSEDKSIRVW 276
V F EL S D + +W
Sbjct: 273 VFTVSFSKGGELFASGGADTQVLLW 297
Score = 99.4 bits (246), Expect = 2e-20
Identities = 68/305 (22%), Positives = 130/305 (42%), Gaps = 30/305 (9%)
Query: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
F+ A + L P + T+ + + LW+++ ++ H V + F
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
L S D +++W R H +R+ F + ++ +AS+D++I+VW+
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI 184
+ + L H H+V CA+F P L+VS S D+T+++WD + + N SD G
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF-----SDSVGF 188
Query: 185 TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDT 244
N+ F+P+ I S D+ VK+W + +K +
Sbjct: 189 -----------------------ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL--LQH 223
Query: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN 304
+ H V+C FHP +++ S D ++++ D+ + + T + + ++
Sbjct: 224 YQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGE 283
Query: 305 LFAAG 309
LFA+G
Sbjct: 284 LFASG 288
Score = 77.4 bits (189), Expect = 8e-14
Identities = 64/286 (22%), Positives = 111/286 (38%), Gaps = 31/286 (10%)
Query: 47 FDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP 106
F H + +D + D + +WN+K + +GH D + + F
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISG 166
+ SAS D+T+R+W R H V F + +AS D++++VW +
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM-- 131
Query: 167 LRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADD 226
R++ L + L H V A F P LIVS ++D
Sbjct: 132 YRQRFL--------------------------YSLYRHTHWVRCAKFSPDGRLIVSCSED 165
Query: 227 RQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQT 286
+ +KIW + V+ + F+P I S D++++VWD+ +Q
Sbjct: 166 KTIKIWDTTNKQC--VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH 223
Query: 287 FRRDHDRFWVLAAHPNLN-LFAAGHDGGMIVFKLERERPAYAVHGN 331
++ ++ HP+ N L A DG + + L R Y + G+
Sbjct: 224 YQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269
Score = 74.7 bits (182), Expect = 5e-13
Identities = 53/233 (22%), Positives = 96/233 (41%), Gaps = 28/233 (12%)
Query: 3 TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQ 62
++F+ +A V+ + F ++ T+ + I++W + H VR F
Sbjct: 96 SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD 155
Query: 63 QPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNW 122
L VS +D IK+W+ ++C+ + + F+ I SA DQT++VW+
Sbjct: 156 GRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
Query: 123 QSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVR 182
+ + H+ V C FHP+ + +++AS D T+++ D+
Sbjct: 216 RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL------------------ 257
Query: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
+ + + L+GH V +F L SG D QV +WR N
Sbjct: 258 ----------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Score = 51.2 bits (121), Expect = 6e-06
Identities = 25/78 (32%), Positives = 41/78 (52%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
+L ++ S V +SFHP +++T+ +G +++ D LI H GPV + F
Sbjct: 220 LLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS 279
Query: 61 KQQPLFVSGGDDYKIKVW 78
K LF SGG D ++ +W
Sbjct: 280 KGGELFASGGADTQVLLW 297
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 102 bits (255), Expect = 2e-21
Identities = 76/288 (26%), Positives = 132/288 (45%), Gaps = 28/288 (9%)
Query: 41 CTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTF 100
CTL+ H V + F S D I +W + TL GH I
Sbjct: 35 CTLVG----HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVA 90
Query: 101 FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVR 160
+ + ++SASDD+T+++W+ +S C+ L GH++YV C F+P +L++S S D+TV+
Sbjct: 91 WSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 161 VWDI-SGLRKKNLSP-----GAVESDVRGITGVDLFGTTDAV-----------VKHVLEG 203
+W++ +G K LS AV + G + + G+ D + +K +++
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSG--SLIVSGSYDGLCRIWDAASGQCLKTLVDD 208
Query: 204 HDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH---PR 260
+ V++ F P I++ D +K+W + + + T GH N C +
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC--LKTYTGHKNEKYCIFANFSVTG 266
Query: 261 QELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
+ I+S SED + +W++ + VQ + D A HP NL A+
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIAS 314
Score = 88.6 bits (218), Expect = 3e-17
Identities = 69/256 (26%), Positives = 108/256 (42%), Gaps = 30/256 (11%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
++++ + ++LWD R + H V +F+ L +SG D +K+W K
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLT-GHNHYVMCAQ 142
+CL TL H D + F+ I+S S D R+W+ S C+ L N V +
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 143 FHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLE 202
F P +++A+LD T+++WD S R G F T
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN---FSVT--------- 265
Query: 203 GHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQE 262
G W IVSG++D V IW + + V +GH + V A HP +
Sbjct: 266 ----GGKW---------IVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVISAACHPTEN 310
Query: 263 LILSNS--EDKSIRVW 276
LI S + DK+I++W
Sbjct: 311 LIASAALENDKTIKLW 326
Score = 81.6 bits (200), Expect = 4e-15
Identities = 48/167 (28%), Positives = 82/167 (49%), Gaps = 6/167 (3%)
Query: 2 LTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKF-DEHDGPVRGIDFH 60
L S V + F+ I++ ++G+ ++WD + D+ + PV + F
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
Query: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP---WILSASDDQTI 117
++ D +K+W+Y RCL T GH + F + WI+S S+D +
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 279
Query: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL--DQTVRVW 162
+WN Q++ V L GH V+ A HPTE+L+ SA+L D+T+++W
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 77.0 bits (188), Expect = 1e-13
Identities = 61/227 (26%), Positives = 101/227 (44%), Gaps = 36/227 (15%)
Query: 16 SFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
+F+P I++ + +++W+ + + H PV + F+ L VSG D
Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLC 191
Query: 76 KVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTG 133
++W+ +CL TL+ D +F F +IL+A+ D T+++W++ C+ TG
Sbjct: 192 RIWDAASGQCLKTLVDD-DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Query: 134 HNH--YVMCAQFHPT-EDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLF 190
H + Y + A F T +VS S D V +W++
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ------------------------- 285
Query: 191 GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA--DDRQVKIWRMN 235
T + V K L+GH V AA HPT LI S A +D+ +K+W N
Sbjct: 286 -TKEIVQK--LQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/207 (24%), Positives = 90/207 (43%), Gaps = 35/207 (16%)
Query: 109 LSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLR 168
LS+S +Q+ V + C L GH V +F P + + S+S D+ + +W
Sbjct: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW------ 68
Query: 169 KKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQ 228
G D + L GH+ ++ A+ +VS +DD+
Sbjct: 69 ----------------------GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKT 106
Query: 229 VKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR 288
+K+W + K + T +GH N V C F+P LI+S S D+++++W++ ++T
Sbjct: 107 LKLWDVRSGKC--LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLS 164
Query: 289 RDHDRFWVLAAHPNLN---LFAAGHDG 312
D V A H N + + + +DG
Sbjct: 165 AHSDP--VSAVHFNCSGSLIVSGSYDG 189
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 102 bits (253), Expect = 3e-21
Identities = 62/272 (22%), Positives = 124/272 (45%), Gaps = 30/272 (11%)
Query: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
F +A + LSF+P+ + T + +LWD + + H + + F+
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
++G D+ + VW+ R + L+GH I + F+ + IL+ S D+T ++W+ +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI 184
CV LTGH+ ++ + F T L+ +AS D T R++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAA------------------- 333
Query: 185 TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDT 244
T + K LEGH+ ++ +F+P +++G+ D+ +IW + +V
Sbjct: 334 -------TRKCIAK--LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV-- 382
Query: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVW 276
GH + + F+ + ++++ S+D + R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 92.0 bits (227), Expect = 3e-18
Identities = 72/300 (24%), Positives = 123/300 (41%), Gaps = 17/300 (5%)
Query: 25 LTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ-PLFVSGGDDYKIKVWNYKLR 83
+T ++ +LWD ++ + H V I F+ +G D K+W+ +
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQF 143
+C T GH I F+ + + + S D T ++W+ Q+ V L GH+ ++ F
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 144 HPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRG---------ITG-----VDL 189
+ + D +++ S D TV VWD RK N+ G +TG L
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 190 FGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHY 249
+ T+ L GHD + + F T LI + + D +I+ K + GH
Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC--IAKLEGHE 345
Query: 250 NNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAG 309
+S F+P+ +L+ S DK+ R+WD +Q D + A + N+ G
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Score = 90.1 bits (222), Expect = 1e-17
Identities = 80/343 (23%), Positives = 140/343 (40%), Gaps = 44/343 (12%)
Query: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEY-PWI 108
H P+ + +K F++G D K+W+ L TL GH + + F++ Y I
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI 150
Query: 109 LSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLR 168
+ S D+T ++W+ ++ C GH ++C F+P LV + S+D T ++WDI
Sbjct: 151 ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ--- 207
Query: 169 KKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQ 228
G +++ L GH + +F+ + I++G+ D
Sbjct: 208 ----------------NGEEVY---------TLRGHSAEIISLSFNTSGDRIITGSFDHT 242
Query: 229 VKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR 288
V +W + + +V+ GH +S A F+ LIL+ S DK+ ++WD + V T
Sbjct: 243 VVVWDADTGR--KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 289 RDHDRFWVLAAHPNLNLFA-AGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQ---- 343
D L A A DG +F + + G+ K F Q
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
Query: 344 LDFNSSKDVAV--------MQLRSGSKFPVFNMSYNPAENAVL 378
L +S K + +Q+ G +F+ ++N N V+
Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVI 403
Score = 33.9 bits (76), Expect = 0.98
Identities = 14/77 (18%), Positives = 34/77 (44%)
Query: 2 LTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHK 61
+ K E + +SF+P+ +LT + ++WD + + + H + F+
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNY 397
Query: 62 QQPLFVSGGDDYKIKVW 78
+ + ++G D ++W
Sbjct: 398 KGNIVITGSKDNTCRIW 414
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 100 bits (249), Expect = 8e-21
Identities = 67/244 (27%), Positives = 107/244 (43%), Gaps = 31/244 (12%)
Query: 33 IQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGH 92
+ LW I H PV + + + L V+G I+VW+ + + L TL+GH
Sbjct: 45 VNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGH 104
Query: 93 LDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVS 152
I + FH ++ S S D I++W+ + + CV GH+ V C +F P + S
Sbjct: 105 KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 153 ASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAA 212
A+ D TV++WD L+ G + S+ G TG VN
Sbjct: 165 AADDHTVKLWD--------LTAGKMMSEFPGHTG--------------------PVNVVE 196
Query: 213 FHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKS 272
FHP L+ SG+ DR ++ W + + + V G V +F+P + S +D S
Sbjct: 197 FHPNEYLLASGSSDRTIRFWDLEKFQV--VSCIEGEPGPVRSVLFNPDGCCLYSGCQD-S 253
Query: 273 IRVW 276
+RV+
Sbjct: 254 LRVY 257
Score = 96.7 bits (239), Expect = 1e-19
Identities = 48/171 (28%), Positives = 81/171 (47%), Gaps = 3/171 (1%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
V+ + + I+ +G I++WD ++ H + +DFH SG
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 72 DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL 131
D IK+W+ + + C+F GH +R F + W+ SA+DD T+++W+ + +
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 132 TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNL---SPGAVES 179
GH V +FHP E L+ S S D+T+R WD+ + + PG V S
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRS 236
Score = 65.5 bits (158), Expect = 3e-10
Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 1/128 (0%)
Query: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
++ S V+ L F P W+ ++ + ++LWD ++ +F H GPV ++FH +
Sbjct: 142 RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE 201
Query: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
L SG D I+ W+ + + + + G +R+ F+ + + S D ++RV+ W+
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWE 260
Query: 124 SRTCVCVL 131
C V+
Sbjct: 261 PERCFDVV 268
Score = 63.5 bits (153), Expect = 1e-09
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 1/153 (0%)
Query: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
A + L FHP ++ + + I+LWD R + ++ H VR + F S
Sbjct: 106 ANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASA 165
Query: 70 GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC 129
DD+ +K+W+ + + GH + FH + S S D+TIR W+ + V
Sbjct: 166 ADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVS 225
Query: 130 VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
+ G V F+P + S D ++RV+
Sbjct: 226 CIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
Score = 57.4 bits (137), Expect = 8e-08
Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 15/185 (8%)
Query: 201 LEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPR 260
L GH V + LIV+G+ +++W + +K + T GH N+ FHP
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKI--LRTLMGHKANICSLDFHPY 116
Query: 261 QELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVF--- 317
E + S S+D +I++WD+ ++ V +R L P+ A+ D +
Sbjct: 117 GEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Query: 318 ---KLERERPAYAVHGNMLHYVKDRFL-------RQLDFNSSKDVAVMQLRSGSKFPVFN 367
K+ E P + N++ + + +L R + F + V+ G PV +
Sbjct: 177 TAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRS 236
Query: 368 MSYNP 372
+ +NP
Sbjct: 237 VLFNP 241
Score = 39.3 bits (90), Expect = 0.023
Identities = 21/90 (23%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
M+++F + V + FHP + + + I+ WD ++ + GPVR + F+
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
Query: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLL 90
SG D ++V+ ++ RC +L
Sbjct: 241 PDGCCLYSGCQD-SLRVYGWEPERCFDVVL 269
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 97.1 bits (240), Expect = 9e-20
Identities = 74/220 (33%), Positives = 98/220 (44%), Gaps = 38/220 (17%)
Query: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
VSG DD +KVW+ +CL TL+GH + ++ I+S S D+T++VWN ++
Sbjct: 277 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNAETGE 334
Query: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
C+ L GH V C H E VVS S D T+RVWDI TG
Sbjct: 335 CIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIE-------------------TG 373
Query: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
L HVL GH V + +VSGA D VK+W + T +
Sbjct: 374 QCL---------HVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETC--LHTLQ 420
Query: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQT 286
GH N V F ++S S D SIRVWD+ + T
Sbjct: 421 GHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHT 458
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/229 (27%), Positives = 110/229 (48%), Gaps = 25/229 (10%)
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
+ +SG D +KVWN + C+ TL GH +R H + ++S S D T+RVW+ ++
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIET 372
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWD------ISGLRKKNLSPGAVE 178
C+ VL GH V C Q+ VVS + D V+VWD + L+ +++
Sbjct: 373 GQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430
Query: 179 SD----VRGI--TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIW 232
D V G T + ++ H L GH + ++VSG D VKIW
Sbjct: 431 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 488
Query: 233 RMNESKAWEVDTCRG---HYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
+ + + T +G H + V+C F+ + ++++S+D ++++WD+
Sbjct: 489 DIKTGQC--LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 533
Score = 64.3 bits (155), Expect = 7e-10
Identities = 41/158 (25%), Positives = 82/158 (51%), Gaps = 11/158 (6%)
Query: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
A V+ + + +R +++ ++ ++++WD T + H V + F VSG
Sbjct: 384 AAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSG 439
Query: 70 GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC 129
D I+VW+ + C+ TL GH T+ + ++S + D T+++W+ ++ C+
Sbjct: 440 SLDTSIRVWDVETGNCIHTLTGHQSL--TSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 497
Query: 130 VLTGHNHY---VMCAQFHPTEDLVVSASLDQTVRVWDI 164
L G N + V C QF+ ++ V+++S D TV++WD+
Sbjct: 498 TLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 533
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 97.1 bits (240), Expect = 9e-20
Identities = 74/220 (33%), Positives = 98/220 (44%), Gaps = 38/220 (17%)
Query: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
VSG DD +KVW+ +CL TL+GH + ++ I+S S D+T++VWN ++
Sbjct: 395 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNAETGE 452
Query: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
C+ L GH V C H E VVS S D T+RVWDI TG
Sbjct: 453 CIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIE-------------------TG 491
Query: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
L HVL GH V + +VSGA D VK+W + T +
Sbjct: 492 QCL---------HVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETC--LHTLQ 538
Query: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQT 286
GH N V F ++S S D SIRVWD+ + T
Sbjct: 539 GHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHT 576
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/229 (27%), Positives = 110/229 (48%), Gaps = 25/229 (10%)
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
+ +SG D +KVWN + C+ TL GH +R H + ++S S D T+RVW+ ++
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIET 490
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWD------ISGLRKKNLSPGAVE 178
C+ VL GH V C Q+ VVS + D V+VWD + L+ +++
Sbjct: 491 GQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
Query: 179 SD----VRGI--TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIW 232
D V G T + ++ H L GH + ++VSG D VKIW
Sbjct: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 606
Query: 233 RMNESKAWEVDTCRG---HYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
+ + + T +G H + V+C F+ + ++++S+D ++++WD+
Sbjct: 607 DIKTGQC--LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 651
Score = 64.3 bits (155), Expect = 7e-10
Identities = 41/158 (25%), Positives = 82/158 (51%), Gaps = 11/158 (6%)
Query: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
A V+ + + +R +++ ++ ++++WD T + H V + F VSG
Sbjct: 502 AAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSG 557
Query: 70 GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC 129
D I+VW+ + C+ TL GH T+ + ++S + D T+++W+ ++ C+
Sbjct: 558 SLDTSIRVWDVETGNCIHTLTGHQSL--TSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 615
Query: 130 VLTGHNHY---VMCAQFHPTEDLVVSASLDQTVRVWDI 164
L G N + V C QF+ ++ V+++S D TV++WD+
Sbjct: 616 TLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 651
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 97.1 bits (240), Expect = 9e-20
Identities = 74/220 (33%), Positives = 98/220 (44%), Gaps = 38/220 (17%)
Query: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
VSG DD +KVW+ +CL TL+GH + ++ I+S S D+T++VWN ++
Sbjct: 315 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNAETGE 372
Query: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
C+ L GH V C H E VVS S D T+RVWDI TG
Sbjct: 373 CIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIE-------------------TG 411
Query: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
L HVL GH V + +VSGA D VK+W + T +
Sbjct: 412 QCL---------HVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETC--LHTLQ 458
Query: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQT 286
GH N V F ++S S D SIRVWD+ + T
Sbjct: 459 GHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHT 496
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/229 (27%), Positives = 110/229 (48%), Gaps = 25/229 (10%)
Query: 65 LFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQS 124
+ +SG D +KVWN + C+ TL GH +R H + ++S S D T+RVW+ ++
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIET 410
Query: 125 RTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWD------ISGLRKKNLSPGAVE 178
C+ VL GH V C Q+ VVS + D V+VWD + L+ +++
Sbjct: 411 GQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468
Query: 179 SD----VRGI--TGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIW 232
D V G T + ++ H L GH + ++VSG D VKIW
Sbjct: 469 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIW 526
Query: 233 RMNESKAWEVDTCRG---HYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
+ + + T +G H + V+C F+ + ++++S+D ++++WD+
Sbjct: 527 DIKTGQC--LQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 571
Score = 64.3 bits (155), Expect = 7e-10
Identities = 41/158 (25%), Positives = 82/158 (51%), Gaps = 11/158 (6%)
Query: 10 ARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG 69
A V+ + + +R +++ ++ ++++WD T + H V + F VSG
Sbjct: 422 AAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSG 477
Query: 70 GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC 129
D I+VW+ + C+ TL GH T+ + ++S + D T+++W+ ++ C+
Sbjct: 478 SLDTSIRVWDVETGNCIHTLTGHQSL--TSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 535
Query: 130 VLTGHNHY---VMCAQFHPTEDLVVSASLDQTVRVWDI 164
L G N + V C QF+ ++ V+++S D TV++WD+
Sbjct: 536 TLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDL 571
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 94.7 bits (234), Expect = 5e-19
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 24/228 (10%)
Query: 108 ILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS-- 165
I+S D +I++W+ S C+ VLTGH V+C Q+ E ++V+ S D TVRVWD++
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 310
Query: 166 -----------GLRKKNLSPGAVE--SDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAA 212
+ S G + S R I D+ TD ++ VL GH VN
Sbjct: 311 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 370
Query: 213 FHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKS 272
F IVS + DR +K+W + S V T GH ++C + R L++S S D +
Sbjct: 371 FDD--KYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNT 424
Query: 273 IRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLE 320
IR+WD+ ++ H+ N + + +DG + V+ L+
Sbjct: 425 IRLWDIECGACLRVL-EGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 471
Score = 79.0 bits (193), Expect = 3e-14
Identities = 70/283 (24%), Positives = 121/283 (42%), Gaps = 48/283 (16%)
Query: 2 LTKFETKSARVKG---LSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
L + + +S KG L + ++ I++ L + I++WD + H G V +
Sbjct: 230 LQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ 287
Query: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIR 118
+ ++ + V+G D ++VW+ L TL+ H + + F + +++ S D++I
Sbjct: 288 YDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIA 343
Query: 119 VWNWQSRTCVC---VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
VW+ S T + VL GH V F + +VSAS D+T++VW
Sbjct: 344 VWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVW------------- 388
Query: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
T+ L GH RG+ A L+VSG+ D +++W +
Sbjct: 389 ---------------STSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIE 431
Query: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
V GH V C F ++ I+S + D I+VWD+
Sbjct: 432 CGACLRV--LEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDL 470
Score = 41.6 bits (96), Expect = 0.005
Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+++ + I+LWD + + H+ VR I F ++ VSG D KIKVW+ +
Sbjct: 416 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQAA 473
Query: 84 R---------CLFTLLGHLDYI-RTTFFHHEYPWILSASDDQTIRVWNW 122
CL TL+ H + R F + I+S+S D TI +W++
Sbjct: 474 LDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 519
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 94.7 bits (234), Expect = 5e-19
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 24/228 (10%)
Query: 108 ILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS-- 165
I+S D +I++W+ S C+ VLTGH V+C Q+ E ++V+ S D TVRVWD++
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 276
Query: 166 -----------GLRKKNLSPGAVE--SDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAA 212
+ S G + S R I D+ TD ++ VL GH VN
Sbjct: 277 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 336
Query: 213 FHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKS 272
F IVS + DR +K+W + S V T GH ++C + R L++S S D +
Sbjct: 337 FDD--KYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNT 390
Query: 273 IRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLE 320
IR+WD+ ++ H+ N + + +DG + V+ L+
Sbjct: 391 IRLWDIECGACLRVL-EGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 437
Score = 79.0 bits (193), Expect = 3e-14
Identities = 70/283 (24%), Positives = 121/283 (42%), Gaps = 48/283 (16%)
Query: 2 LTKFETKSARVKG---LSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
L + + +S KG L + ++ I++ L + I++WD + H G V +
Sbjct: 196 LQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ 253
Query: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIR 118
+ ++ + V+G D ++VW+ L TL+ H + + F + +++ S D++I
Sbjct: 254 YDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIA 309
Query: 119 VWNWQSRTCVC---VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
VW+ S T + VL GH V F + +VSAS D+T++VW
Sbjct: 310 VWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVW------------- 354
Query: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
T+ L GH RG+ A L+VSG+ D +++W +
Sbjct: 355 ---------------STSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIE 397
Query: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
V GH V C F ++ I+S + D I+VWD+
Sbjct: 398 CGACLRV--LEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDL 436
Score = 41.6 bits (96), Expect = 0.005
Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+++ + I+LWD + + H+ VR I F ++ VSG D KIKVW+ +
Sbjct: 382 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQAA 439
Query: 84 R---------CLFTLLGHLDYI-RTTFFHHEYPWILSASDDQTIRVWNW 122
CL TL+ H + R F + I+S+S D TI +W++
Sbjct: 440 LDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 485
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 94.7 bits (234), Expect = 5e-19
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 24/228 (10%)
Query: 108 ILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS-- 165
I+S D +I++W+ S C+ VLTGH V+C Q+ E ++V+ S D TVRVWD++
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 297
Query: 166 -----------GLRKKNLSPGAVE--SDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAA 212
+ S G + S R I D+ TD ++ VL GH VN
Sbjct: 298 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 357
Query: 213 FHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKS 272
F IVS + DR +K+W + S V T GH ++C + R L++S S D +
Sbjct: 358 FDD--KYIVSASGDRTIKVW--STSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNT 411
Query: 273 IRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLE 320
IR+WD+ ++ H+ N + + +DG + V+ L+
Sbjct: 412 IRLWDIECGACLRVL-EGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQ 458
Score = 79.0 bits (193), Expect = 3e-14
Identities = 70/283 (24%), Positives = 121/283 (42%), Gaps = 48/283 (16%)
Query: 2 LTKFETKSARVKG---LSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
L + + +S KG L + ++ I++ L + I++WD + H G V +
Sbjct: 217 LQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ 274
Query: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIR 118
+ ++ + V+G D ++VW+ L TL+ H + + F + +++ S D++I
Sbjct: 275 YDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIA 330
Query: 119 VWNWQSRTCVC---VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
VW+ S T + VL GH V F + +VSAS D+T++VW
Sbjct: 331 VWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVW------------- 375
Query: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
T+ L GH RG+ A L+VSG+ D +++W +
Sbjct: 376 ---------------STSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIE 418
Query: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
V GH V C F ++ I+S + D I+VWD+
Sbjct: 419 CGACLRV--LEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDL 457
Score = 41.6 bits (96), Expect = 0.005
Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 15/109 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+++ + I+LWD + + H+ VR I F ++ VSG D KIKVW+ +
Sbjct: 403 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQAA 460
Query: 84 R---------CLFTLLGHLDYI-RTTFFHHEYPWILSASDDQTIRVWNW 122
CL TL+ H + R F + I+S+S D TI +W++
Sbjct: 461 LDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ---IISSSHDDTILIWDF 506
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 94.4 bits (233), Expect = 6e-19
Identities = 68/228 (29%), Positives = 104/228 (45%), Gaps = 26/228 (11%)
Query: 108 ILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS-- 165
I+S D TI++W+ + C +LTGH V+C Q+ E ++++ S D TVRVWD++
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
Query: 166 --------------GLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWA 211
LR N D R I D+ TD ++ VL GH VN
Sbjct: 338 EMLNTLIHHCEAVLHLRFNNGMMVTCSKD-RSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
Query: 212 AFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDK 271
F IVS + DR +K+W N S V T GH ++C + R L++S S D
Sbjct: 397 DFDD--KYIVSASGDRTIKVW--NTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDN 450
Query: 272 SIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKL 319
+IR+WD+ ++ H+ N + + +DG + V+ L
Sbjct: 451 TIRLWDIECGACLRVL-EGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 497
Score = 77.8 bits (190), Expect = 6e-14
Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 43/258 (16%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
I++ L + I++WD H G V + + ++ + ++G D ++VW+
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTG 337
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC---VLTGHNHYVMC 140
L TL+ H + + F++ +++ S D++I VW+ S T + VL GH V
Sbjct: 338 EMLNTLIHHCEAVLHLRFNN--GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 141 AQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHV 200
F + +VSAS D+T++VW+ T+
Sbjct: 396 VDF--DDKYIVSASGDRTIKVWN----------------------------TSTCEFVRT 425
Query: 201 LEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPR 260
L GH RG+ A L+VSG+ D +++W + V GH V C F +
Sbjct: 426 LNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIECGACLRV--LEGHEELVRCIRFDNK 481
Query: 261 QELILSNSEDKSIRVWDM 278
+ I+S + D I+VWD+
Sbjct: 482 R--IVSGAYDGKIKVWDL 497
Score = 40.0 bits (92), Expect = 0.014
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 15/109 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+++ + I+LWD + + H+ VR I F ++ VSG D KIKVW+
Sbjct: 443 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVAA 500
Query: 84 R---------CLFTLLGHLDYI-RTTFFHHEYPWILSASDDQTIRVWNW 122
CL TL+ H + R F + I+S+S D TI +W++
Sbjct: 501 LDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ---IVSSSHDDTILIWDF 546
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 94.4 bits (233), Expect = 6e-19
Identities = 68/228 (29%), Positives = 104/228 (45%), Gaps = 26/228 (11%)
Query: 108 ILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS-- 165
I+S D TI++W+ + C +LTGH V+C Q+ E ++++ S D TVRVWD++
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
Query: 166 --------------GLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWA 211
LR N D R I D+ TD ++ VL GH VN
Sbjct: 374 EMLNTLIHHCEAVLHLRFNNGMMVTCSKD-RSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
Query: 212 AFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDK 271
F IVS + DR +K+W N S V T GH ++C + R L++S S D
Sbjct: 433 DFDD--KYIVSASGDRTIKVW--NTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDN 486
Query: 272 SIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKL 319
+IR+WD+ ++ H+ N + + +DG + V+ L
Sbjct: 487 TIRLWDIECGACLRVL-EGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 533
Score = 77.8 bits (190), Expect = 6e-14
Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 43/258 (16%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
I++ L + I++WD H G V + + ++ + ++G D ++VW+
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTG 373
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC---VLTGHNHYVMC 140
L TL+ H + + F++ +++ S D++I VW+ S T + VL GH V
Sbjct: 374 EMLNTLIHHCEAVLHLRFNN--GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
Query: 141 AQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHV 200
F + +VSAS D+T++VW+ T+
Sbjct: 432 VDF--DDKYIVSASGDRTIKVWN----------------------------TSTCEFVRT 461
Query: 201 LEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPR 260
L GH RG+ A L+VSG+ D +++W + V GH V C F +
Sbjct: 462 LNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIECGACLRV--LEGHEELVRCIRFDNK 517
Query: 261 QELILSNSEDKSIRVWDM 278
+ I+S + D I+VWD+
Sbjct: 518 R--IVSGAYDGKIKVWDL 533
Score = 40.0 bits (92), Expect = 0.014
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 15/109 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+++ + I+LWD + + H+ VR I F ++ VSG D KIKVW+
Sbjct: 479 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVAA 536
Query: 84 R---------CLFTLLGHLDYI-RTTFFHHEYPWILSASDDQTIRVWNW 122
CL TL+ H + R F + I+S+S D TI +W++
Sbjct: 537 LDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ---IVSSSHDDTILIWDF 582
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 93.2 bits (230), Expect = 1e-18
Identities = 71/271 (26%), Positives = 111/271 (40%), Gaps = 37/271 (13%)
Query: 9 SARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68
S V G SF P R ++L+S +G ++LW + T + + H+ PV F FVS
Sbjct: 543 SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVS 602
Query: 69 GGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCV 128
GG D ++W + L GHL + T FH ++ + S D+T+R+W+ + CV
Sbjct: 603 GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV 662
Query: 129 CVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVD 188
+ TGH + F P + + + D V +WDI G+ +
Sbjct: 663 RIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG----------------HGLMVGE 706
Query: 189 LFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIW----RMNESKAWEVDT 244
L G TD V F ++ SG+ D V++W + + + T
Sbjct: 707 LKGHTDTVCS------------LRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTT 754
Query: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRV 275
GH N + QEL+L KS V
Sbjct: 755 ATGHIN-----LPENSQELLLGTYMTKSTPV 780
Score = 78.6 bits (192), Expect = 3e-14
Identities = 58/225 (25%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 71 DDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCV 130
DD ++ + K L L GH + F + ++LS+S+D T+R+W+ Q+ TC+
Sbjct: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
Query: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI-----T 185
GHN+ V QF P VS D+ R+W + + G + +DV +
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL-ADVNCTRFHPNS 639
Query: 186 GVDLFGTTDAVVK----------HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
G+ D V+ + GH ++ F P + +GA D +V +W +
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSK 280
V +GH + V F E++ S S D ++R+WD K
Sbjct: 700 HGLM--VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 71.6 bits (174), Expect = 4e-12
Identities = 60/260 (23%), Positives = 102/260 (39%), Gaps = 41/260 (15%)
Query: 57 IDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQT 116
+D L G D ++VW+ ++ +R+ + I SDD
Sbjct: 476 VDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESDDVL 524
Query: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGA 176
R+ + ++ + + +L GH+ V A F P + ++S+S D TVR+W +
Sbjct: 525 ERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------- 573
Query: 177 VESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNE 236
T L G +GH+ V F P VSG DR ++W +
Sbjct: 574 --------TFTCLVG---------YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDH 616
Query: 237 SKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWV 296
+ + GH +V+C FHP + + S D+++R+WD+ V+ F
Sbjct: 617 YQPLRI--FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS 674
Query: 297 LAAHPNLNLFAAGHDGGMIV 316
L PN A G G ++
Sbjct: 675 LTFSPNGRFLATGATDGRVL 694
Score = 45.1 bits (105), Expect = 4e-04
Identities = 62/276 (22%), Positives = 105/276 (38%), Gaps = 64/276 (23%)
Query: 128 VCVLTGHNHYVMCAQFHPTED--LVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGIT 185
+C T N Y T+D L+ D TVRVW +
Sbjct: 461 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV--------------------- 499
Query: 186 GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTC 245
T ++ V + D + LI +DD +I M+E A E+
Sbjct: 500 -------TPKKLRSVKQASD-----------LSLIDKESDDVLERI--MDEKTASELKIL 539
Query: 246 RGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNL 305
GH V A F P + +LS+SED ++R+W + T + ++ + W P
Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599
Query: 306 F-AAGHDGGMIVFKLERERPAYAVHGNML-----------HYV----KDRFLRQLDFNSS 349
F + GHD ++ + +P G++ +YV DR +R D +
Sbjct: 600 FVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 659
Query: 350 KDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASN 385
V + +G K P+ +++++P N L T A++
Sbjct: 660 NCVRIF---TGHKGPIHSLTFSP--NGRFLATGATD 690
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 89.4 bits (220), Expect = 2e-17
Identities = 61/236 (25%), Positives = 94/236 (39%), Gaps = 31/236 (13%)
Query: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
H G VR I FV+G D IK+W+ + +L GH+ +R P++
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
Query: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRK 169
S +D+ ++ W+ + + GH V HPT D++V+ S D T R+WD+
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV----- 317
Query: 170 KNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQV 229
T A V H L GH V P I++G+ D +
Sbjct: 318 ----------------------RTKASV-HTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354
Query: 230 KIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQ 285
++W + K T H +V V HPR S S D +I+ W + +Q
Sbjct: 355 RLWDLVAGKTRV--TLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQ 407
Score = 88.6 bits (218), Expect = 3e-17
Identities = 68/300 (22%), Positives = 122/300 (40%), Gaps = 35/300 (11%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
V+ ++ P W +T + I++WD L H VRG+ + P S G+
Sbjct: 207 VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
Query: 72 DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL 131
D ++K W+ + + + GHL + H +++ S D T R+W+ +++ V L
Sbjct: 267 DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTL 326
Query: 132 TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFG 191
+GH + V + E +++ S D T+R+WD+ V G T V
Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL----------------VAGKTRV---- 366
Query: 192 TTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN 251
L H + V HP SG+ D +K W+ + + GH N
Sbjct: 367 --------TLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSF--IQNLSGH-NA 414
Query: 252 VSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD 311
+ + +++S +++ ++ +WD RTG F+R H + +FA D
Sbjct: 415 IINTLTVNSDGVLVSGADNGTMHLWDW--RTG-YNFQRVHAAVQPGSLDSESGIFACAFD 471
Score = 67.4 bits (163), Expect = 8e-11
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 20/196 (10%)
Query: 130 VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGI----T 185
V++GH +V C P V+ S D+T+++WD++ + K G + S VRG+
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHI-STVRGVIVSTR 257
Query: 186 GVDLFGTTD------------AVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWR 233
LF + V++H GH V HPT+ ++V+ + D +IW
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRH-YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Query: 234 MNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDR 293
+ +KA V T GH N V+ + I++ S D +IR+WD+ T
Sbjct: 317 V-RTKA-SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
Query: 294 FWVLAAHPNLNLFAAG 309
+ HP FA+G
Sbjct: 375 VRAVVLHPRHYTFASG 390
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 87.8 bits (216), Expect = 6e-17
Identities = 58/245 (23%), Positives = 103/245 (42%), Gaps = 33/245 (13%)
Query: 36 WDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDY 95
+DY++ + F H+ PV + + + VS G+D KV L T GH D+
Sbjct: 340 FDYKLKNI---FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDW 396
Query: 96 IRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL 155
+ FH + ++S D T+++W+ C+ GH+ V +H + V S+SL
Sbjct: 397 LSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456
Query: 156 DQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
D+T ++WD++ R + L GH VN F P
Sbjct: 457 DKTSKIWDVNSER----------------------------CRCTLYGHTDSVNSIEFFP 488
Query: 216 TMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRV 275
+++ + D+ + IW + + GH ++++ A+F PR +I S ++
Sbjct: 489 FSNTLLTSSADKTLSIWDARTGICEQ--SLYGHMHSINDAIFDPRGHMIASCDACGVTKL 546
Query: 276 WDMSK 280
WD K
Sbjct: 547 WDFRK 551
Score = 80.9 bits (198), Expect = 7e-15
Identities = 58/230 (25%), Positives = 91/230 (39%), Gaps = 15/230 (6%)
Query: 17 FHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
FHP + TS + ++LWD I F+ H V +H S D K
Sbjct: 402 FHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 461
Query: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNH 136
+W+ RC TL GH D + + F +L++S D+T+ +W+ ++ C L GH H
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 521
Query: 137 YVMCAQFHPTEDLVVSASLDQTVRVWDISGL-------------RKKNL-SPGAVESDVR 182
+ A F P ++ S ++WD L + N S G V +
Sbjct: 522 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 581
Query: 183 GITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIW 232
G + L + H L GH+ + F ++ SG D V+ W
Sbjct: 582 GNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 46.6 bits (109), Expect = 1e-04
Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 3/139 (2%)
Query: 194 DAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVS 253
D +K++ H+ V+ + P ++VS +DR K+ + K + T GH + +S
Sbjct: 341 DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKV--LGLPKCNVLLTGFGHTDWLS 398
Query: 254 CAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGH-DG 312
FHP + + ++S D ++++WD+ K + TF W H N A+ D
Sbjct: 399 DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDK 458
Query: 313 GMIVFKLERERPAYAVHGN 331
++ + ER ++G+
Sbjct: 459 TSKIWDVNSERCRCTLYGH 477
Score = 40.4 bits (93), Expect = 0.010
Identities = 26/105 (24%), Positives = 43/105 (40%), Gaps = 1/105 (0%)
Query: 17 FHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
F P+ I + GV +LWD+R I D P ++F + + I
Sbjct: 528 FDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIH 587
Query: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
+ + K + L+GH + T F H+ + S D T+R W+
Sbjct: 588 LLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 87.4 bits (215), Expect = 7e-17
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 28/226 (12%)
Query: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
++GG D + V++ + L TL GH + + FH + SAS D TIR+W+ + +
Sbjct: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
Query: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
CV V+ H V H T D ++S+S DQ W S ++ TG
Sbjct: 298 CVQVVRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFSDIQ----------------TG 338
Query: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
L TD E + A FHP + +G D Q+KIW + E V
Sbjct: 339 RVLTKVTD-------ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT--NVANFP 389
Query: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHD 292
GH ++ F + + ++D S+++WD+ K +T + D++
Sbjct: 390 GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNN 435
Score = 58.9 bits (141), Expect = 3e-08
Identities = 46/217 (21%), Positives = 84/217 (38%), Gaps = 30/217 (13%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
ILT + + ++D ++ H V + FH Q L S D I++W+
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNH--YVMCA 141
C+ + H + H ++LS+SDDQ + Q+ + +T + CA
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
Query: 142 QFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVL 201
QFHP + + ++D +++WD+ + N++
Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLK--ERTNVAN--------------------------F 388
Query: 202 EGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESK 238
GH + AF + + ADD VK+W + + K
Sbjct: 389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
Score = 53.9 bits (128), Expect = 9e-07
Identities = 34/170 (20%), Positives = 71/170 (41%), Gaps = 2/170 (1%)
Query: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
+L + + +V + FHP + + ++ + I++W + + H+ V G+ H
Sbjct: 256 ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315
Query: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIR 118
+S DD + + R L + T FH + + + D I+
Sbjct: 316 ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIK 375
Query: 119 VWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLR 168
+W+ + RT V GH+ + F + +A+ D +V++WD+ L+
Sbjct: 376 IWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
Score = 50.1 bits (118), Expect = 1e-05
Identities = 45/192 (23%), Positives = 80/192 (41%), Gaps = 25/192 (13%)
Query: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMS 279
I++G D+ V ++ ++S + T +GH V+ VFHP Q+L+ S S D +IR+W +
Sbjct: 237 ILTGGADKNVVVF--DKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
Query: 280 KRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDG----------GMIVFKLERERPAYAVH 329
+ VQ R L+ H + + D G ++ K+ E ++
Sbjct: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
Query: 330 GNMLH--------YVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCT 381
H D ++ D +VA SG P+ ++++ +EN L T
Sbjct: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG---PITSIAF--SENGYYLAT 409
Query: 382 RASNLENSTYDL 393
A + +DL
Sbjct: 410 AADDSSVKLWDL 421
Score = 47.0 bits (110), Expect = 1e-04
Identities = 34/167 (20%), Positives = 70/167 (41%), Gaps = 5/167 (2%)
Query: 1 MLTKF--ETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
+LTK ET + FHP T + I++WD + T + F H GP+ I
Sbjct: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399
Query: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTL-LGHLDYIRTTFFHHEYPWILSASDDQTI 117
F + + DD +K+W+ + + TL L + +++ F ++ D +
Sbjct: 400 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--V 457
Query: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
+++ + T + T H+ F + S +D++++ + +
Sbjct: 458 QIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 86.3 bits (212), Expect = 2e-16
Identities = 58/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 65 LFVSGGDDYKIKVWN---YKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWN 121
LF +G D I++W+ +K + ++ H D++ ++SAS D T++VWN
Sbjct: 45 LFTAGRDSI-IRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
Query: 122 WQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
C+ L H YV + ++LV SA LD+ + +WD++ L
Sbjct: 104 AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL-------------- 149
Query: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWE 241
L + + V L G+ + A + +IVSG+ ++ +++W + +
Sbjct: 150 -----TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW--DPRTCAK 202
Query: 242 VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHP 301
+ +GH +NV + + LS S D +IR+W + ++ + T+R + W L +
Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262
Query: 302 NL-NLFAAGHD 311
++++ G D
Sbjct: 263 AFTHVYSGGRD 273
Score = 51.2 bits (121), Expect = 6e-06
Identities = 35/172 (20%), Positives = 69/172 (40%), Gaps = 9/172 (5%)
Query: 2 LTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLI---------DKFDEHDG 52
++ T VK L++ + + ++ + I LWD T + +
Sbjct: 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKD 169
Query: 53 PVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS 112
+ + ++ + VSG + ++VW+ + L L GH D ++ + + LS S
Sbjct: 170 SIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGS 229
Query: 113 DDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
D TIR+W+ + C+ H+ V Q + V S D+ + D+
Sbjct: 230 SDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
Score = 38.5 bits (88), Expect = 0.040
Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 2/115 (1%)
Query: 196 VVKHVLEGHDR-GVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNN-VS 253
V++ +E ++R GVN P + + + D ++IW +N+ K H+ + V+
Sbjct: 20 VIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVN 79
Query: 254 CAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAA 308
V + ++S S D +++VW+ K + T R D LA + L A+
Sbjct: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134
Score = 38.1 bits (87), Expect = 0.052
Identities = 31/147 (21%), Positives = 57/147 (38%), Gaps = 27/147 (18%)
Query: 138 VMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197
V Q P + + +A D +R+W ++ ++ D +
Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQ------------------------DPYI 68
Query: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257
+E H VN ++S + D VK+W N K + + T R H + V +
Sbjct: 69 AS-MEHHTDWVNDIVLCCNGKTLISASSDTTVKVW--NAHKGFCMSTLRTHKDYVKALAY 125
Query: 258 HPRQELILSNSEDKSIRVWDMSKRTGV 284
+EL+ S D+ I +WD++ T +
Sbjct: 126 AKDKELVASAGLDRQIFLWDVNTLTAL 152
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 85.1 bits (209), Expect = 4e-16
Identities = 55/214 (25%), Positives = 93/214 (43%), Gaps = 37/214 (17%)
Query: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
+ T +G ++LWD R I F ++ V + F+ +SGG D IKVW+ +
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ----SRTCVCVLTGHNHY-- 137
+ +T+ GH D + E ++LS + D T+RVW+ + CV + G+ H
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 138 --VMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDA 195
++ + P + + S D+ V VWD TT
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWD----------------------------TTSR 317
Query: 196 VVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQV 229
+ + L GH +N AFHP P+I+S + D+++
Sbjct: 318 RILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 83.2 bits (204), Expect = 1e-15
Identities = 66/231 (28%), Positives = 99/231 (42%), Gaps = 33/231 (14%)
Query: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWN-YKLRRCLFTLLGHLDYIRTTFFHHEYPWI 108
H+G V FH S G D I +WN Y TL GH + ++ + +
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
Query: 109 LSASDDQTIRVWNWQSRTCVCVLTGHNHYV-MCAQFHPTEDLVVSASLDQTVRVWDISGL 167
SAS D+T+ VW+ ++ V L GH +V C LV + S D TV++WDI
Sbjct: 125 FSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI--- 181
Query: 168 RKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDR 227
RKK + F T V+ F+ T I+SG D
Sbjct: 182 RKK--------------AAIQTFQNTYQVLA------------VTFNDTSDQIISGGIDN 215
Query: 228 QVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 278
+K+W + ++K T RGH ++V+ +LSN+ D ++RVWD+
Sbjct: 216 DIKVWDLRQNKL--TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264
Score = 79.3 bits (194), Expect = 2e-14
Identities = 61/283 (21%), Positives = 126/283 (44%), Gaps = 31/283 (10%)
Query: 17 FHPKRPWILTSLHNGVIQLWD-YRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
FHP + ++ + +I LW+ Y C H G V + ++ + S D +
Sbjct: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
Query: 76 KVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL-SASDDQTIRVWNWQSRTCVCVLTGH 134
VW+ + + L GH ++ + + P ++ + SDD T+++W+ + + + +
Sbjct: 134 AVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-N 192
Query: 135 NHYVMCAQFHPTEDLVVSASLDQTVRVWD----------------ISGLRKKN----LSP 174
+ V+ F+ T D ++S +D ++VWD ++GL + L
Sbjct: 193 TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLS 252
Query: 175 GAVESDVRGITGVDLFGTTDAVVKHVLEGH----DRGVNWAAFHPTMPLIVSGADDRQVK 230
A+++ VR + V F + VK + +G+ ++ + ++ P I +G+ DR V
Sbjct: 253 NAMDNTVR-VWDVRPFAPKERCVK-IFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310
Query: 231 IWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSI 273
+W + + GH +++ FHP + +I+S S DK +
Sbjct: 311 VWDTTSRRI--LYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 69.7 bits (169), Expect = 2e-11
Identities = 45/205 (21%), Positives = 89/205 (43%), Gaps = 30/205 (14%)
Query: 128 VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGV 187
+ +L+GH V C +FHP + SA D+ + +W++ G
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG-------------------DC 99
Query: 188 DLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRG 247
D + T L+GH V ++ ++ S + D+ V +W + V +G
Sbjct: 100 DNYAT--------LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE--RVKRLKG 149
Query: 248 HYNNV-SCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLF 306
H + V SC +L+ + S+D ++++WD+ K+ +QTF+ + V + +
Sbjct: 150 HTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQII 209
Query: 307 AAGHDGGMIVFKLERERPAYAVHGN 331
+ G D + V+ L + + Y + G+
Sbjct: 210 SGGIDNDIKVWDLRQNKLTYTMRGH 234
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 81.6 bits (200), Expect = 4e-15
Identities = 67/288 (23%), Positives = 117/288 (40%), Gaps = 41/288 (14%)
Query: 17 FHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
F P ++ G +QL+D L++ D HDG + + Q FV+GG D +K
Sbjct: 462 FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVK 521
Query: 77 VWNYKLRRCLFTLLGHLDYIRT-TFFHHEYPWILSASDDQ----------TIRVWNWQSR 125
W+++L + + L +T T E +S S +Q T++++ +
Sbjct: 522 FWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTL 581
Query: 126 TCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGIT 185
L GH V+C L+ + S D+ V++W
Sbjct: 582 KFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW----------------------- 618
Query: 186 GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTC 245
G+D FG L HD V + F P L + D ++K W + K + T
Sbjct: 619 GLD-FGD----CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW--DADKFEHIQTL 671
Query: 246 RGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDR 293
GH+ + C P + ++S+S DKS+R+W+ ++ + R+ +R
Sbjct: 672 EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMER 719
Score = 59.7 bits (143), Expect = 2e-08
Identities = 35/149 (23%), Positives = 64/149 (42%)
Query: 15 LSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYK 74
+S+ P + + SL + ++++ H PV +D L +G D
Sbjct: 555 VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRN 614
Query: 75 IKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGH 134
+K+W C +L H D + F + +A D I+ W+ + L GH
Sbjct: 615 VKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674
Query: 135 NHYVMCAQFHPTEDLVVSASLDQTVRVWD 163
+ + C P+ D VVS+S D+++R+W+
Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 56.6 bits (135), Expect = 1e-07
Identities = 49/201 (24%), Positives = 79/201 (39%), Gaps = 25/201 (12%)
Query: 47 FDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYP 106
F+ H + + + + SG D I VW+ L+ L GH D I F E
Sbjct: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
Query: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISG 166
++++ D ++ W+ ++ C + GH V E +++ + D +RVWDI+
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
Query: 167 LRK------------KNLSPGAVESDVRGITGVDLFGTTDAVVKHVL----------EGH 204
L++ K SPG ++ + G F T +A +L EG
Sbjct: 223 LQEIEDPEEPDPKKIKGSSPG-IQDTLEAEDGA--FETDEAPEDRILSCRKAGSIMREGR 279
Query: 205 DRGVNWAAFHPTMPLIVSGAD 225
DR VN A L G D
Sbjct: 280 DRVVNLAVDKTGRILACHGTD 300
Score = 46.2 bits (108), Expect = 2e-04
Identities = 60/256 (23%), Positives = 107/256 (41%), Gaps = 31/256 (12%)
Query: 82 LRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141
+R T+ GH +RT F + +LSA+ D +I++WN + C+ +T Y +C+
Sbjct: 404 VRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMT--CEYALCS 460
Query: 142 QFHPTEDLVVSASLDQTVRVWDISG---LRKKNLSPGAVES-----DVRG-ITG------ 186
F P + VV + ++++D++ L + GA+ S D RG +TG
Sbjct: 461 FFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSV 520
Query: 187 ----VDLFGTTDAVVKHVLEGH------DRGVNWAAFHPTMPLIVSGADDRQVKIWRMNE 236
+L ++ K + D V ++ P L+ D VKI+ ++
Sbjct: 521 KFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT 580
Query: 237 SKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWV 296
K + + GH V C LI + S D+++++W + ++ D
Sbjct: 581 LKFFL--SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
Query: 297 LAAHPNLNL-FAAGHD 311
L P +L F AG D
Sbjct: 639 LQFVPKSHLFFTAGKD 654
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/170 (21%), Positives = 65/170 (38%), Gaps = 36/170 (21%)
Query: 113 DDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI---SGLRK 169
+D +IR+++ S GH + ++ + S S D + VWD+ SGL +
Sbjct: 85 EDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR 144
Query: 170 KNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQV 229
L+GH + A F L+V+ D V
Sbjct: 145 -------------------------------LKGHKDAITQALFLREKNLLVTSGKDTMV 173
Query: 230 KIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMS 279
K W ++ ++ T GH V V ++ +++ + D +RVWD++
Sbjct: 174 KWWDLDTQHCFK--TMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA 221
Score = 39.3 bits (90), Expect = 0.023
Identities = 20/89 (22%), Positives = 41/89 (46%)
Query: 33 IQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGH 92
I +WD + + + H + F +++ L V+ G D +K W+ + C T++GH
Sbjct: 131 IIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGH 190
Query: 93 LDYIRTTFFHHEYPWILSASDDQTIRVWN 121
+ E +++ + D +RVW+
Sbjct: 191 RTEVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 36.6 bits (83), Expect = 0.15
Identities = 20/96 (20%), Positives = 45/96 (46%), Gaps = 4/96 (4%)
Query: 203 GHDRGVNWAAFHPTMPLIVSGADDRQVKIWRM-NESKAWEVDTCRGHYNNVSCAVFHPRQ 261
GH + + + SG+ D + +W + NES + + +GH + ++ A+F +
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL---KGHKDAITQALFLREK 161
Query: 262 ELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVL 297
L++++ +D ++ WD+ + +T W L
Sbjct: 162 NLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGL 197
Score = 35.4 bits (80), Expect = 0.34
Identities = 25/96 (26%), Positives = 44/96 (45%)
Query: 69 GGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCV 128
G +D I++++ T GH I T + + S S D I VW+ + + +
Sbjct: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
Query: 129 CVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
L GH + A F ++L+V++ D V+ WD+
Sbjct: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDL 178
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 81.6 bits (200), Expect = 4e-15
Identities = 70/305 (22%), Positives = 122/305 (40%), Gaps = 59/305 (19%)
Query: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
V+ L+FHP P ++T+ + ++LW+ + K F H GPV +
Sbjct: 483 VRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAIS 542
Query: 61 KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
SGG D I+ WN Y+ TL+GH D + + +L
Sbjct: 543 SNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLL 602
Query: 110 SASDDQTIRVWNWQSR-TCVCVLTGHN--------HYVMCAQFHPTEDLVVSASLDQTVR 160
S S D T+R+WN Q + C+C G ++ C H +V S + V
Sbjct: 603 SCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH----MVTSFNTGSAV- 657
Query: 161 VWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLI 220
++D+ + + V+S ++ + +N HPT+P+
Sbjct: 658 IYDLETSQSLVILSSQVDSGLQS---------------------NNHINRVVSHPTLPVT 696
Query: 221 VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSK 280
++ +DR +K + K + + H + V+ P ++S S D SIR+W++
Sbjct: 697 ITAHEDRHIKFFDNKTGKM--IHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 754
Query: 281 RTGVQ 285
+T VQ
Sbjct: 755 KTCVQ 759
Score = 56.6 bits (135), Expect = 1e-07
Identities = 33/150 (22%), Positives = 72/150 (48%), Gaps = 11/150 (7%)
Query: 24 ILTSLHNGVIQLWDYR-------MCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIK 76
++TS + G ++D + + +D + + + + H P+ ++ +D IK
Sbjct: 647 MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIK 706
Query: 77 VWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGH-- 134
++ K + + +++ HLD + + +++S S D +IR+WN S+TCV +T H
Sbjct: 707 FFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRK 766
Query: 135 --NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
+ + FH ++ + SA D +V+
Sbjct: 767 KLDESIYDVAFHSSKAYIASAGADALAKVF 796
Score = 48.9 bits (115), Expect = 3e-05
Identities = 66/324 (20%), Positives = 124/324 (38%), Gaps = 59/324 (18%)
Query: 76 KVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCV---CVLT 132
K WN K +TL H D +R FH P +++AS+D T+++WN Q L
Sbjct: 468 KTWNPK-----YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLD 522
Query: 133 GHNHYVMCAQFHPTEDLVVSAS--------LDQTVRVWDISG-------LRKKNLSPGAV 177
Y A P L +S++ +D T++ W++ + N+ G +
Sbjct: 523 VEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTL 582
Query: 178 ESDVRGITGVDLFGTTDAVVKHVLEGHDR------------------------GVNWAAF 213
+ G+ G + ++ +G R V++
Sbjct: 583 VGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGC 642
Query: 214 HPTMPLIVSGADDRQVKIWRMNESKAW-----EVDTCRGHYNNVSCAVFHPRQELILSNS 268
P +V+ + I+ + S++ +VD+ N+++ V HP + ++
Sbjct: 643 DPAH--MVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAH 700
Query: 269 EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-LNLFAAGHDGGMIVFKLERERPAYA 327
ED+ I+ +D + + D LA PN + L + HD + ++ L+ +
Sbjct: 701 EDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT---C 757
Query: 328 VHGNMLHYVK-DRFLRQLDFNSSK 350
V H K D + + F+SSK
Sbjct: 758 VQEITAHRKKLDESIYDVAFHSSK 781
Score = 36.6 bits (83), Expect = 0.15
Identities = 25/107 (23%), Positives = 43/107 (40%), Gaps = 4/107 (3%)
Query: 18 HPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKV 77
HP P +T+ + I+ +D + +I H V + +SG D I++
Sbjct: 690 HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRL 749
Query: 78 WNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120
WN + C+ + H + I FH +I SA D +V+
Sbjct: 750 WNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 796
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,887,510
Number of Sequences: 37866
Number of extensions: 2154786
Number of successful extensions: 8305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 5209
Number of HSP's gapped (non-prelim): 1720
length of query: 1224
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1110
effective length of database: 13,930,794
effective search space: 15463181340
effective search space used: 15463181340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.