Search of human proteins with 109637765

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109637765 calpastatin isoform i [Homo sapiens]
         (708 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109637765 calpastatin isoform i [Homo sapiens]                    1405   0.0  
gi|109637753 calpastatin isoform a [Homo sapiens]                    1405   0.0  
gi|109637761 calpastatin isoform g [Homo sapiens]                    1356   0.0  
gi|109637763 calpastatin isoform h [Homo sapiens]                    1347   0.0  
gi|27765085 calpastatin isoform b [Homo sapiens]                     1347   0.0  
gi|109637769 calpastatin isoform k [Homo sapiens]                    1311   0.0  
gi|109637757 calpastatin isoform e [Homo sapiens]                    1311   0.0  
gi|109637767 calpastatin isoform j [Homo sapiens]                    1297   0.0  
gi|109637759 calpastatin isoform f [Homo sapiens]                    1297   0.0  
gi|109637771 calpastatin isoform l [Homo sapiens]                    1262   0.0  
gi|27765087 calpastatin isoform c [Homo sapiens]                      781   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     93   1e-18
gi|104526627 triadin [Homo sapiens]                                    71   3e-12
gi|150170670 piccolo isoform 2 [Homo sapiens]                          67   4e-11
gi|150378539 piccolo isoform 1 [Homo sapiens]                          67   4e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   6e-11
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    63   8e-10
gi|109637791 transcription factor-like nuclear regulator [Homo s...    63   8e-10
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    62   1e-09
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    61   3e-09
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    60   5e-09
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   58   3e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   58   3e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   58   3e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    58   3e-08
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho...    57   5e-08
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    57   8e-08
gi|110349719 titin isoform N2-A [Homo sapiens]                         56   1e-07
gi|58082089 hypothetical protein LOC161394 [Homo sapiens]              56   1e-07

>gi|109637765 calpastatin isoform i [Homo sapiens]
          Length = 708

 Score = 1405 bits (3638), Expect = 0.0
 Identities = 708/708 (100%), Positives = 708/708 (100%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708


>gi|109637753 calpastatin isoform a [Homo sapiens]
          Length = 791

 Score = 1405 bits (3638), Expect = 0.0
 Identities = 708/708 (100%), Positives = 708/708 (100%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 143

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 144 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 203

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 204 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 263

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 264 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 323

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 324 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 383

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 384 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 443

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 444 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 503

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 504 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 563

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 564 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 623

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 624 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 683

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 684 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 743

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 791



 Score =  221 bits (564), Expect = 1e-57
 Identities = 196/668 (29%), Positives = 315/668 (47%), Gaps = 71/668 (10%)

Query: 81  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 140
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71

Query: 141 ESKPDKPSGKSGMDAALDDLI---DTLGGP----EETEEENTTYTGPEVSDPMSSTYIEE 193
            +     S  S M+      I     + GP    ++  ++    T PE     +   +  
Sbjct: 72  SASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVH 131

Query: 194 LGKREVTIPPKYRE--LLAKKEGITG-----------------PPADSSKP-IGPDDAID 233
             K +   P ++ E   L K+   TG                 P   S++P   P D I 
Sbjct: 132 EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 191

Query: 234 ALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 293
           A   +   G    +GK  +K++  +        ++  A P + K  K    +  D AL+ 
Sbjct: 192 A-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDD 242

Query: 294 LSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 352
           L  +L G  + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +
Sbjct: 243 LIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--I 298

Query: 353 LPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM 412
              P +  KP    + ID LS DF        P+   +KTE+ ++      +E +   S 
Sbjct: 299 TGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSA 348

Query: 413 CSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDR 467
            +++SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  
Sbjct: 349 GTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 408

Query: 468 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ---- 523
           EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +    
Sbjct: 409 EKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEK 467

Query: 524 -NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQ 580
            +  + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+
Sbjct: 468 PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGK 526

Query: 581 RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 640
           ++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++
Sbjct: 527 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKE 584

Query: 641 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 700
              P  +   +DALS D     + +      AK     +   S+ P +  +A    + T 
Sbjct: 585 QLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS 644

Query: 701 ETSKPKDD 708
           ++ K  DD
Sbjct: 645 QSDKDLDD 652



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 100/387 (25%), Positives = 162/387 (41%), Gaps = 51/387 (13%)

Query: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 411 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 467
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 468 EKLGEKEETIPPDYRLEEVKDKDGKP-------LLPKE----------SKEQLPPMSEDF 510
           EK  +  +       + E K ++GKP        LPK+          +K+ +   +E  
Sbjct: 119 EKKSQSTKLSV----VHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 174

Query: 511 LLDALSEDFSGPQNASSLKFEDAKLAAAIS--------EVVSQTPASTTQAGAPPRDTSQ 562
             +  +E  + PQ+  S   E      AIS        E  S TPA   ++  P + + +
Sbjct: 175 PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGK 233

Query: 563 SDKDLDDALDKLSDSLGQRQPDPDENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHL 621
           S   +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR L
Sbjct: 234 S--GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 291

Query: 622 LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAAS 681
           L    ++    PP     DS KP    D IDALS D  +C S T   + T K++  +   
Sbjct: 292 LAK--KEGITGPPA----DSSKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLK 344

Query: 682 SSKAPKNGGKAKDSAKTTEETSKPKDD 708
           +  A    G  + +A   E+  K + D
Sbjct: 345 AQSA----GTVRSAAPPQEKKRKVEKD 367


>gi|109637761 calpastatin isoform g [Homo sapiens]
          Length = 772

 Score = 1356 bits (3509), Expect = 0.0
 Identities = 689/708 (97%), Positives = 689/708 (97%), Gaps = 19/708 (2%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK                 
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK----------------- 126

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
             PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 127 --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 184

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 185 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 244

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 245 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 304

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 305 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 364

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 365 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 424

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 425 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 484

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 485 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 544

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 545 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 604

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 605 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 664

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 665 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 724

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 725 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772



 Score =  224 bits (570), Expect = 3e-58
 Identities = 195/664 (29%), Positives = 315/664 (47%), Gaps = 82/664 (12%)

Query: 81  KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 121
           + A +R   +  SEK++E  +KP +                     + G  S   ++A S
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75

Query: 122 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 178
           G          + T A+PV  +   P  P+ K     A+           +TE E  + +
Sbjct: 76  GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAV-----------KTEPEKKSQS 124

Query: 179 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSS 237
               S P  ++   + G  +      + +    +     P   S++P   P D I A   
Sbjct: 125 TKPKSLPKQAS---DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GG 175

Query: 238 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 297
           +   G    +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +
Sbjct: 176 ESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDT 227

Query: 298 L-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 356
           L G  + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +   P
Sbjct: 228 LGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPP 283

Query: 357 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 416
            +  KP    + ID LS DF        P+   +KTE+ ++      +E +   S  +++
Sbjct: 284 ADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVR 333

Query: 417 SAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLG 471
           SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK G
Sbjct: 334 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 393

Query: 472 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NAS 526
           E +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  
Sbjct: 394 EDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 452

Query: 527 SLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 584
           + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ D
Sbjct: 453 TEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEAD 511

Query: 585 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 644
           P++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P
Sbjct: 512 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPP 569

Query: 645 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 704
             +   +DALS D     + +      AK     +   S+ P +  +A    + T ++ K
Sbjct: 570 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 629

Query: 705 PKDD 708
             DD
Sbjct: 630 DLDD 633



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)

Query: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 411 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 467
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 468 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 525
           EK  +  K +++P         D   K  + + +++Q    S +          +G ++ 
Sbjct: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178

Query: 526 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 585
           + +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   
Sbjct: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235

Query: 586 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 644
           +EN      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP
Sbjct: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289

Query: 645 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 704
               D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K
Sbjct: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344

Query: 705 PKDD 708
            + D
Sbjct: 345 VEKD 348


>gi|109637763 calpastatin isoform h [Homo sapiens]
          Length = 769

 Score = 1347 bits (3486), Expect = 0.0
 Identities = 686/708 (96%), Positives = 686/708 (96%), Gaps = 22/708 (3%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 84  MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 121

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 122 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 181

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 182 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 241

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 242 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 301

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 302 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 361

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 362 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 421

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 422 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 481

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 482 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 541

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 542 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 601

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 602 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 661

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 662 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 721

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 722 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)

Query: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 411 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 470
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 471 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 530
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 531 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 590
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 591 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 649
               +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291

Query: 650 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345


>gi|27765085 calpastatin isoform b [Homo sapiens]
          Length = 686

 Score = 1347 bits (3486), Expect = 0.0
 Identities = 686/708 (96%), Positives = 686/708 (96%), Gaps = 22/708 (3%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 218

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 219 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 278

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 279 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 338

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 339 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 398

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 399 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 459 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 518

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 519 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 578

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 579 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 638

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 639 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686


>gi|109637769 calpastatin isoform k [Homo sapiens]
          Length = 673

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 673/708 (95%), Positives = 673/708 (95%), Gaps = 35/708 (4%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 205

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 206 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 265

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 266 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 325

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 326 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 385

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 386 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 445

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 446 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 505

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 506 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 565

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 566 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 625

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 626 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673


>gi|109637757 calpastatin isoform e [Homo sapiens]
          Length = 756

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 673/708 (95%), Positives = 673/708 (95%), Gaps = 35/708 (4%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 84  MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 121

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 122 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 181

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 182 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 241

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 242 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 288

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 289 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 348

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 349 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 408

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 409 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 468

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 469 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 528

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 529 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 588

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 589 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 648

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 649 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 708

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 709 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 411 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 470
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 471 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 530
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 531 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 590
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 591 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 649
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278

Query: 650 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332


>gi|109637767 calpastatin isoform j [Homo sapiens]
          Length = 667

 Score = 1297 bits (3357), Expect = 0.0
 Identities = 667/708 (94%), Positives = 667/708 (94%), Gaps = 41/708 (5%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTK                 
Sbjct: 1   MNPTETKA----------------------VKTEPEKKSQSTK----------------- 21

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
             PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 22  --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 79

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 80  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 139

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 140 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 199

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 200 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 259

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 260 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 319

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 320 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 379

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 380 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 439

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 440 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 499

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 500 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 559

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 560 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 619

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 620 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 667


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 1297 bits (3357), Expect = 0.0
 Identities = 667/708 (94%), Positives = 667/708 (94%), Gaps = 41/708 (5%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTK                 
Sbjct: 84  MNPTETKA----------------------VKTEPEKKSQSTK----------------- 104

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
             PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 105 --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 162

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 163 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 222

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 223 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 282

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 283 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 342

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 343 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 402

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 403 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 462

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 463 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 522

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 523 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 582

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 583 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 642

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 643 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 702

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 703 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 408
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50

Query: 409 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 467
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101

Query: 468 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 527
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158

Query: 528 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 587
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215

Query: 588 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 646
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269

Query: 647 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 706
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324

Query: 707 DD 708
            D
Sbjct: 325 KD 326


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 1262 bits (3265), Expect = 0.0
 Identities = 654/708 (92%), Positives = 654/708 (92%), Gaps = 54/708 (7%)

Query: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
           MNPTETKA                      VKTEPEKKSQSTK                 
Sbjct: 1   MNPTETKA----------------------VKTEPEKKSQSTK----------------- 21

Query: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
             PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 22  --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 79

Query: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 80  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 139

Query: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 140 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 186

Query: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 187 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 246

Query: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 247 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 306

Query: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 307 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 366

Query: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 367 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 426

Query: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 427 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 486

Query: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 487 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 546

Query: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 547 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 606

Query: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 607 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score =  781 bits (2017), Expect = 0.0
 Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)

Query: 316 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 375
           D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39  DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98

Query: 376 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 435
           FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99  FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158

Query: 436 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 495
           ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218

Query: 496 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 555
           PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278

Query: 556 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 615
           PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337

Query: 616 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 675
           PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397

Query: 676 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
           CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  206 bits (525), Expect = 5e-53
 Identities = 144/396 (36%), Positives = 213/396 (53%), Gaps = 30/396 (7%)

Query: 191 IEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 247
           +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF        
Sbjct: 48  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105

Query: 248 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 296
            K ++  E TE  KA +   V  A           APP+    K    T+ D A+EAL+ 
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162

Query: 297 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 355
           SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221

Query: 356 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 415
            +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + 
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274

Query: 416 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 475
           Q+  P   T      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334

Query: 476 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 533
           TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + +      A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394

Query: 534 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 569
           K     +   S+ P +  +A    + T ++ K  DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  122 bits (306), Expect = 1e-27
 Identities = 100/301 (33%), Positives = 150/301 (49%), Gaps = 31/301 (10%)

Query: 123 KPGDKKKEKKSLTPA-----------VPVESKPDKPSGKSGM--DAALDDLIDTLGGPEE 169
           KP +K +E K+  PA             ++S P +P+   G   D A++ L D+LG  +E
Sbjct: 110 KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG-KKE 168

Query: 170 TEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR-ELLAKKEGITGPPADSSK---P 225
            + E+      +V +       E+LG++E TIPP YR E +  K+G    P +S +   P
Sbjct: 169 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 228

Query: 226 IGPDDAIDALSSDFTCGSPTAAGKKTEKEE----STEVLKAQSAGTVRSAAPPQEKKRKV 281
           +  D  +DALS DF+ G   A+  K E  +     +EV+    A T ++ APP    R  
Sbjct: 229 MSEDFLLDALSEDFS-GPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----RDT 283

Query: 282 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 341
             D   D AL+ LS SLG RQ +P+ + + +++  + KAK E  +K GE D+TIP EYR 
Sbjct: 284 SSDKDLDDALDKLSDSLGQRQPDPD-ENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 342

Query: 342 ---KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 398
                  DK  KP   + E+  KP  + + ID LS D D      + S+ T K +  KAA
Sbjct: 343 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 402

Query: 399 A 399
           +
Sbjct: 403 S 403



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 67/266 (25%), Positives = 114/266 (42%), Gaps = 14/266 (5%)

Query: 32  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 91
           K E + +     +  V EK  +E + K   + +++P         D   K  + + +++Q
Sbjct: 166 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 225

Query: 92  PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSG 149
               S +          +G ++ + +     K      E  S TPA   ++   P   S 
Sbjct: 226 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSS 285

Query: 150 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 209
              +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR LL
Sbjct: 286 DKDLDDALDKLSDSLGQRQPDPDENKPMED-KVKEKAKAEHRDKLGERDDTIPPEYRHLL 344

Query: 210 AK--KEGITGPPA----DSSKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKA 262
               ++    PP     DS KP    D IDALS D  +C S T   + T K++  +   +
Sbjct: 345 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 404

Query: 263 QSA----GTVRSAAPPQEKKRKVEKD 284
             A    G  + +A   E+  K + D
Sbjct: 405 SKAPKNGGKAKDSAKTTEETSKPKDD 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 155/657 (23%), Positives = 257/657 (39%), Gaps = 85/657 (12%)

Query: 9    IPVSQQMEGPHLPNKKKHKKQAVKTEPEKK--SQSTKLSVVHEKKSQEGKPKEHTEPKSL 66
            IP S     P +P+   H K  VK+E + K   +S K +V+ E++++E +  E    +  
Sbjct: 418  IPFSLPEGLPKIPSVSTHIK--VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475

Query: 67   PKQASDTGSNDAHNKKAVSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISG 122
             +   + G  +   ++  +   E++    P+E++  P+ + +  +    +S A       
Sbjct: 476  KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EA 530

Query: 123  KPGDKKKEKKSLTPAVPVESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 181
            K  +K++ K       P ++K P K   KS  +A           PE+ E ++      E
Sbjct: 531  KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK---------SPEKEEAKSPA----E 577

Query: 182  VSDP--MSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSD 238
            V  P    S   EE         P+  +   K+E  +  PA++  P+  +    A + S 
Sbjct: 578  VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS--PAEAKSPVKEEAKSPAEVKSP 635

Query: 239  FTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 297
                SPT    K  EK +S E  +A+S    +S    + K  +  K  +  +A     A 
Sbjct: 636  EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695

Query: 298  LGTRQA--EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPE 355
               ++    PE     +KE  EAK+ E+      E+ +T   E    P  ++   P    
Sbjct: 696  SPVKEEAKSPEKAKSPVKE--EAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSP---- 747

Query: 356  PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 415
              EK K   +++ +D  S +  ++  KE+   P +K  E    A +PV E V        
Sbjct: 748  --EKAKSPEKAKTLDVKSPEA-KTPAKEEARSPADKFPEK---AKSPVKEEV-------- 793

Query: 416  QSAPPEPATLKGTVPDDAVEALADSLGKKEADP----EDGKPVMDKVKEKAKEEDREKLG 471
                  P   K  + +DA +A    + KKE       E+ KP   KVKE  K+ + EK  
Sbjct: 794  ----KSPEKAKSPLKEDA-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA- 847

Query: 472  EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFE 531
                  P   + EE KD   K   PK  KE   P  E+    A+ +       A   + E
Sbjct: 848  ------PATPKTEEKKDSK-KEEAPK--KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898

Query: 532  DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM 591
            D K      E  +       +   P   T  + K+ DDA  K      +++    E K  
Sbjct: 899  DKKKVPT-PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957

Query: 592  --------EDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 640
                    E+K K +AKA+  DK   ++ + P   +     +   K  KPP K +ED
Sbjct: 958  KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 138/596 (23%), Positives = 225/596 (37%), Gaps = 57/596 (9%)

Query: 136 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 195
           P +P  S   K   +  +        +T+   E+TEE   T    EV++       EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483

Query: 196 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 255
           K E     +  E    +E    PPA+ +    P+   +A S         A  K  EKEE
Sbjct: 484 KEEEG--GEEEEAEGGEEETKSPPAEEAA--SPEK--EAKSPVKEEAKSPAEAKSPEKEE 537

Query: 256 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 315
           +    + +S    +S A  + K     K    ++A          +   P  +    K  
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSP 595

Query: 316 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 375
            EAK+ E+      E+ ++ P+E +     +      +  PE+   P  E     E ++ 
Sbjct: 596 AEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654

Query: 376 FDRSECK--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPD 431
            ++ E K  EK   P +   +S   A +PV +EA       S ++     P   K  V +
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714

Query: 432 DAVEA-LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 489
           +A     A S  K+EA  PE  K     VKE+AK  ++ K  EK +T+       +VK  
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSP 764

Query: 490 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISE 541
           + K    +E++       E      + E+   P+ A S   EDAK             S 
Sbjct: 765 EAKTPAKEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823

Query: 542 VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-- 599
           V  +      +   PP+   +         ++  DS  +  P  +  KP  ++ KE A  
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 600 -----KAEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPI 651
                K E + +  E    +P PE         ++ P K   K+    K+  +   ++P 
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPD 934

Query: 652 DALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 706
           DA + +        E +      K +KA    + PK   KAK+  KT ++E SKPK
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/528 (23%), Positives = 208/528 (39%), Gaps = 67/528 (12%)

Query: 205 YRELLAKKEGITG-PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 263
           YR+LL  +E   G  P   S P G    I ++S+     S        + E+ T +++ Q
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460

Query: 264 SAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ---------AEPELDLRS-I 312
           +  T V      +E+K   E++   ++  E   A  G  +         A PE + +S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520

Query: 313 KEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 370
           KE  +  A+AK  + E+     E    E    PA ++   P   +  EK + +S +E+  
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-- 578

Query: 371 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 430
             S +  +S  KE+   P E     KA +P              ++     PA  K  V 
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSP--------------VKEEAKSPAEAKSPVK 623

Query: 431 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 490
           ++A         K  A+ +  +      KE+AK  ++ K  EKEE   P+     VK + 
Sbjct: 624 EEA---------KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 491 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 550
             P   K S  +    S +     + E+   P+ A S   E+AK        V +   + 
Sbjct: 675 KSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733

Query: 551 TQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK--VKEKA 599
            +A +P ++ ++S          K LD    +      +    P +  P + K  VKE+ 
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793

Query: 600 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 659
           K+  + K   ++D   PE      +  + + VK P K+ E  ++    + P  A   + +
Sbjct: 794 KSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA---EEE 845

Query: 660 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 707
             P+T +T +   KD  K+ A   +AP    K K   K      KPK+
Sbjct: 846 KAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 114/525 (21%), Positives = 196/525 (37%), Gaps = 67/525 (12%)

Query: 2   NPTETKAIPVSQQMEGP---HLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 58
           +P +    PV ++ + P     P K++ K  A    PEK     K      K   E K  
Sbjct: 511 SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA---KSPPEAKSP 567

Query: 59  EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 118
           E  E KS P +        +  K+     AE +  EK+  P    ++   +  E+ + + 
Sbjct: 568 EKEEAKS-PAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV---KEEAKSPAEAKSPVK 623

Query: 119 AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 178
             +  P + K  +K+ +P       P+K       +A           PE+ +       
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK---------SPEKAKS------ 668

Query: 179 GPEVSDPMSSTYIEELGKREVTIPPK----YRELLAKKEGITGPPADSSKPIGPDDAIDA 234
            P  ++  S    +   K E   P K     +E     E    P  + +K   P+ A   
Sbjct: 669 -PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK--SPEKAKSP 725

Query: 235 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 294
           +  +        +  K E +   +    + A T+   +P  +   K E  + +D+  E  
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785

Query: 295 SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDK-- 347
            + +      PE     +KE  +AKA E+++ K  E      +E  P E ++K    K  
Sbjct: 786 KSPVKEEVKSPEKAKSPLKE--DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE 843

Query: 348 -DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 406
            +  P  P+ EEK   + E    +   ++  + + +EK     EK +ESK          
Sbjct: 844 EEKAPATPKTEEKKDSKKE----EAPKKEAPKPKVEEKKEPAVEKPKESKV--------- 890

Query: 407 VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEED 466
                      A  E A  K  VP    EA A    K++A P++   V  K  + AK ++
Sbjct: 891 ----------EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 467 REKLGEKEETIP--PDYRLEEVKDKDGKPLLPKESKEQLPPMSED 509
             K  EK+E  P   D + E+ K  + KP    ++KE    +S++
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 98/430 (22%), Positives = 170/430 (39%), Gaps = 45/430 (10%)

Query: 2    NPTETKAIPVSQQMEGP---HLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 58
            +P + K+ PV ++ + P     P K++ K  A    PEK    TK      +K++  + +
Sbjct: 600  SPEKAKS-PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658

Query: 59   EHTEP---KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 115
            E   P   KS  K  + +        KA ++S E+  S    E K+  +       E+ +
Sbjct: 659  EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718

Query: 116  GITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA-ALDDLIDTLGGPEETEEEN 174
               A S    + K  +K+ +P       P+K   KS   A  LD        P + E  +
Sbjct: 719  PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK--AKSPEKAKTLDVKSPEAKTPAKEEARS 776

Query: 175  TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA------KKEGITGPPADSSKP--I 226
                 PE +    S   EE+   E    P   +  A      KKE +  P  +  KP  +
Sbjct: 777  PADKFPEKA---KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833

Query: 227  GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 286
               +       +    +P    KK  K+E     +A          P  EK ++ + +  
Sbjct: 834  KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893

Query: 287  SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 346
             ++A +        ++A  +++++     ++AK KE K E   ++ +   ++   KPA  
Sbjct: 894  KEEAEDKKKVPTPEKEAPAKVEVK-----EDAKPKE-KTEVAKKEPDDAKAKEPSKPAEK 947

Query: 347  KDGKP--------LLPEPEEKPKPRSESELIDE-LSEDFDR---------SECKEKPSKP 388
            K+  P           +PEEKPK  ++++  D+ LS++  +         S   +K SKP
Sbjct: 948  KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007

Query: 389  TEKTEESKAA 398
             EK  E KAA
Sbjct: 1008 PEKATEDKAA 1017



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)

Query: 450 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 499
           +G P +  V    K K E++ K+ EK        EE        EEV +++ K    +E 
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 500 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 559
           KE+     E        E   G +   S   E+A              +   +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522

Query: 560 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 618
            ++S  +              + P+ +E K P E K  EKAK+  +++     +   PE 
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 619 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 678
                      P K  +   E++K PA+ + P  A S   +   S  E +++  K++ K 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628

Query: 679 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
            A      K     K+ AK+ E+   P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 131/661 (19%), Positives = 247/661 (37%), Gaps = 121/661 (18%)

Query: 14  QMEGPHLPNKKKHKKQAVKTE-PEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASD 72
           +++ P L  K+ HK +  K E PE+K Q+       EK  ++ + KE  E K+  K+  +
Sbjct: 132 EIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIE 191

Query: 73  TGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKK 132
               +    K +++  ++  + + +E KTK +                  K G ++K K+
Sbjct: 192 --KKEKPETKTLAKEQKKAKTAEKSEEKTKKEV-----------------KGGKQEKVKQ 232

Query: 133 SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYI 191
           +      V+  P KP                    E+ ++E    +  E  D  +   Y+
Sbjct: 233 TAAKVKEVQKTPSKPK-------------------EKEDKEKAAVSKHEQKDQYAFCRYM 273

Query: 192 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKT 251
            ++          + +L   +     PP  + +   P  A  AL             KK 
Sbjct: 274 IDIFV--------HGDLKPGQSPAIPPPLPTEQASRPTPASPALEEK------EGEKKKA 319

Query: 252 EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 311
           EK+ ++E  K +           ++ K+K EK+T  D   +    +  T+Q   ++  ++
Sbjct: 320 EKKVTSETKKKEK----------EDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQA 369

Query: 312 IKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDE 371
             + DE K   +K +K        P+E        ++ K    EP + PK         E
Sbjct: 370 AAKKDEKKEDSKKTKK--------PAEVEQPKGKKQEKKEKHVEPAKSPK--------KE 413

Query: 372 LSEDFDRS-ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 430
            S   D+  + K + +K        K A P    E   +T    I+         K    
Sbjct: 414 HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE-------KSGKT 466

Query: 431 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 490
              ++      GK+E  P   K   +K  E  K+E   K G++ +  PP  +L+  K++ 
Sbjct: 467 SSILKDKEPIKGKEEKVPASLK---EKEPETKKDEKMSKAGKEVKPKPP--QLQGKKEEK 521

Query: 491 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 550
            +P + KE+K   P +SE   +    +D   P+   S    + K       V+ Q  A T
Sbjct: 522 PEPQIKKEAK---PAISEKVQIH--KQDIVKPEKTVSHGKPEEK-------VLKQVKAVT 569

Query: 551 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 610
            +  A P+ T +++       ++   S+   +P P      E     K K E    + E+
Sbjct: 570 IEKTAKPKPTKKAEH-----REREPPSIKTDKPKPTPKGTSEVTESGKKKTE----ISEK 620

Query: 611 DDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQN 670
           +     + +HL ++    +           ++KPA        +S D++  P++ +  + 
Sbjct: 621 ESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA-------RVSKDVEDVPASKKAKEG 673

Query: 671 T 671
           T
Sbjct: 674 T 674



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 119/541 (21%), Positives = 207/541 (38%), Gaps = 64/541 (11%)

Query: 5   ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 64
           ETK +   Q+       +++K KK+    + EK  Q+   + V E +    KPKE  +  
Sbjct: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA--AKVKEVQKTPSKPKEKED-- 252

Query: 65  SLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGESVAGI 117
              K+ +    ++  ++ A  R         + +P +    P   P +  S         
Sbjct: 253 ---KEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS---RPTPAS 306

Query: 118 TAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 177
            A+  K G+KKK +K +T     + K D    KS  + A+D      G   ET++     
Sbjct: 307 PALEEKEGEKKKAEKKVTSETKKKEKEDIKK-KSEKETAIDVEKKEPGKASETKQGTVKI 365

Query: 178 TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSS 237
                +         +  K+   +     +   KKE    P     K         ++ S
Sbjct: 366 AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE-------HSVPS 418

Query: 238 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 297
           D    + T   K  E+  +  + KA             E++ + EK   +   L+     
Sbjct: 419 DKQVKAKTERAK--EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPI 476

Query: 298 LGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPE 357
            G  +  P     S+KE +    K+EK+ K G++ +  P + + K    K+ KP  P+ +
Sbjct: 477 KGKEEKVP----ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK----KEEKP-EPQIK 527

Query: 358 EKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE-------SKAAAPAPVSEAVCR- 409
           ++ KP + SE +    +D  + E      KP EK  +        K A P P  +A  R 
Sbjct: 528 KEAKP-AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRE 586

Query: 410 TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 469
               SI++  P+P T KGT   +  E+     GKK+ +  + +    K K   K    EK
Sbjct: 587 REPPSIKTDKPKP-TPKGT--SEVTES-----GKKKTEISEKE---SKEKADMKHLREEK 635

Query: 470 LGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLK 529
           +  ++E++    +L  V  K  KP    +  E +P   +       +ED S  +  S + 
Sbjct: 636 VSTRKESL----QLHNV-TKAEKPARVSKDVEDVPASKK---AKEGTEDVSPTKQKSPIS 687

Query: 530 F 530
           F
Sbjct: 688 F 688



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 89/398 (22%), Positives = 150/398 (37%), Gaps = 71/398 (17%)

Query: 3   PTE-----TKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK-KSQSTKLSVVHEKKSQEGK 56
           PTE     T A P  ++ EG     +KK   +  K E E  K +S K + +  +K + GK
Sbjct: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGK 354

Query: 57  PKEHTEPK-SLPKQASDTGSNDAHNKKAVSRSAE-QQPSEKSTEPKTK------------ 102
             E  +    +  QA+        + K   + AE +QP  K  E K K            
Sbjct: 355 ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414

Query: 103 --PQD-----MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 155
             P D           E +  ++     PG  KKE+K+ T  V  E + +K SGK+   +
Sbjct: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPG--KKEEKT-TKTVEQEIRKEK-SGKT--SS 468

Query: 156 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGI 215
            L D  + + G EE    +     PE          E++ K    + PK  +L  KKE  
Sbjct: 469 ILKDK-EPIKGKEEKVPASLKEKEPETKKD------EKMSKAGKEVKPKPPQLQGKKEEK 521

Query: 216 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 275
             P           + +     D      T +  K E+    +VLK   A T+   A P+
Sbjct: 522 PEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEE----KVLKQVKAVTIEKTAKPK 577

Query: 276 EKKR-----------KVEKDTMSDQALEALSAS------LGTRQAEPELDLRSIKEVDEA 318
             K+           K +K   + +    ++ S      +  ++++ + D++ ++E   +
Sbjct: 578 PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVS 637

Query: 319 KAKE----------EKLEKCGEDDETIPSEYRLKPATD 346
             KE          EK  +  +D E +P+  + K  T+
Sbjct: 638 TRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)

Query: 424 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 483
           T KG + +  +        K E   +  + +  KV  K KE+ +EK+ EKE+        
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187

Query: 484 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 543
           E+++ K+ KP     +KEQ    + +   +   ++  G       K E  K  AA  + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240

Query: 544 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 588
            +TP+   +     +      +  D               D     S ++    P    +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 589 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 640
           +P      +E+K  EK KAE                          K V   TKK   ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334

Query: 641 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 700
            KK ++ +  ID    +       +ET Q T K   + AA   +  ++  K K  A+  +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391

Query: 701 ETSKPKD 707
              K ++
Sbjct: 392 PKGKKQE 398


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 182/812 (22%), Positives = 296/812 (36%), Gaps = 138/812 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHKKQAVKT--EPEKKSQSTKLSVVHEKKSQEGKPKEHT 61
            T T A+  S        P K    KQ +    EP+K     K   +H   S + K     
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 62   EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 121
            +  S P    +       +K  V+    +QP  K  +P T   D++S+   S      I 
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQP--KMVKPTT---DLVSS--SSATTKPDIP 779

Query: 122  GKPGDKKKEKKSLTPAVPVESKPDK---PSGK--SGMDA------ALDDLIDTLGGPEET 170
                  + E+K+  P     +KP +   P+G+  S  D+      A D  I +  GP   
Sbjct: 780  SSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSE 839

Query: 171  EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGP------------ 218
             +      G +  DP+     EE  K +  + PK       K   T P            
Sbjct: 840  SK------GQKQVDPVQKK--EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891

Query: 219  PADSSKP--------IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 270
            P  S KP        +      DA  S  T    T  GK      S   + +Q++  + +
Sbjct: 892  PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGAS---IFSQASNLIST 948

Query: 271  AAPPQEKKRK-----VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA-KEEK 324
            A  P    +      +++     Q   +      T QA P    +SI    E KA   EK
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQA-PPAPAKSIPVKKETKAPAAEK 1007

Query: 325  LEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DELS 373
            LE   E   T+  +E   KP   KD K L  EP         E+ PKP S   L   EL+
Sbjct: 1008 LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELN 1067

Query: 374  ------EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
                   +F+  +ECK +        PT   TE  +       ++      +  I+  PP
Sbjct: 1068 IGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPP 1127

Query: 421  EPATLKGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK------ 463
             P+  K +   VP +      AV      + K+E +   E  K +++KVKE         
Sbjct: 1128 APSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPP 1187

Query: 464  -------------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLPPM 506
                         E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P  
Sbjct: 1188 MVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKPTP 1243

Query: 507  SEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD-----TS 561
             +  LL          Q    LK   +++  A  ++  +    T Q G  P+       S
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPS 1300

Query: 562  QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEYRH 620
             + + L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+   
Sbjct: 1301 GTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358

Query: 621  LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK--- 677
             L D G        +     S  P D++D +  L  D  S  S+  +  + AK +     
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418

Query: 678  --KAASSSKAPKNGGKAKDSAKTTEETSKPKD 707
              +A +S+ A +   K     + + E  +PKD
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 149/710 (20%), Positives = 259/710 (36%), Gaps = 152/710 (21%)

Query: 3    PTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTE 62
            PTE+     SQ+   P      K ++Q VKTE EK        V+ EK       KE   
Sbjct: 1140 PTESS----SQKTAVPPQVKLVKKQEQEVKTEAEK--------VILEKV------KETLS 1181

Query: 63   PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 122
             + +P   +     +    +    SA Q+      E K  P++      E    +     
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKP 1241

Query: 123  KPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL-------GGPEETEEEN- 174
             P DKK   ++ T A P E K D    KS +  A + L   +       G   +T+ E  
Sbjct: 1242 TPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL 1298

Query: 175  ---TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLAKKEGITGPPADSSKPI 226
               T  + P+  D  + T  E+       K +   P K +    +KE      + S +P 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---TEKEDDKSDTSSSQQPK 1355

Query: 227  GPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQSAGTVRSAAPPQEKKRK 280
             P    D   SSD   G  ++ G+      T++++  + LK  S     S + P +   K
Sbjct: 1356 SPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLA-K 1411

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAKAKEEKLEKCGEDDETI 335
            +E   +S   LEA +++L   ++E +     +     K+ ++ ++  E LE    ++E  
Sbjct: 1412 LESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIK 1469

Query: 336  PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 395
             S+   K    KD +  +P  ++    + +SE +D+++             +P +  EES
Sbjct: 1470 ESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR----------REPYDSVEES 1516

Query: 396  KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 455
              +  +PV +   RTS+ S  S                                      
Sbjct: 1517 SESENSPVPQRKRRTSVGSSSS-------------------------------------- 1538

Query: 456  DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 515
                ++ K+ED +  GE+E+ I     +E   D+D                 ++F+ + L
Sbjct: 1539 ----DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQL 1582

Query: 516  SEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKL 574
             E  S  ++    + +   K+ A     +++  +++    A  R  S  D+D D+A D+ 
Sbjct: 1583 KEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE- 1639

Query: 575  SDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNG 626
            S  L  R+    E+   E+ V        R K  E + TI  +Y          L  D  
Sbjct: 1640 SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEE 1696

Query: 627  QDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDSCPS 663
             +  ++  T   ED  +             P      + +L  D DS PS
Sbjct: 1697 PELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 182/812 (22%), Positives = 296/812 (36%), Gaps = 138/812 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHKKQAVKT--EPEKKSQSTKLSVVHEKKSQEGKPKEHT 61
            T T A+  S        P K    KQ +    EP+K     K   +H   S + K     
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 62   EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 121
            +  S P    +       +K  V+    +QP  K  +P T   D++S+   S      I 
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQP--KMVKPTT---DLVSS--SSATTKPDIP 779

Query: 122  GKPGDKKKEKKSLTPAVPVESKPDK---PSGK--SGMDA------ALDDLIDTLGGPEET 170
                  + E+K+  P     +KP +   P+G+  S  D+      A D  I +  GP   
Sbjct: 780  SSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSE 839

Query: 171  EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGP------------ 218
             +      G +  DP+     EE  K +  + PK       K   T P            
Sbjct: 840  SK------GQKQVDPVQKK--EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891

Query: 219  PADSSKP--------IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 270
            P  S KP        +      DA  S  T    T  GK      S   + +Q++  + +
Sbjct: 892  PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGAS---IFSQASNLIST 948

Query: 271  AAPPQEKKRK-----VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA-KEEK 324
            A  P    +      +++     Q   +      T QA P    +SI    E KA   EK
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQA-PPAPAKSIPVKKETKAPAAEK 1007

Query: 325  LEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DELS 373
            LE   E   T+  +E   KP   KD K L  EP         E+ PKP S   L   EL+
Sbjct: 1008 LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELN 1067

Query: 374  ------EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
                   +F+  +ECK +        PT   TE  +       ++      +  I+  PP
Sbjct: 1068 IGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPP 1127

Query: 421  EPATLKGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK------ 463
             P+  K +   VP +      AV      + K+E +   E  K +++KVKE         
Sbjct: 1128 APSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPP 1187

Query: 464  -------------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLPPM 506
                         E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P  
Sbjct: 1188 MVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKPTP 1243

Query: 507  SEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD-----TS 561
             +  LL          Q    LK   +++  A  ++  +    T Q G  P+       S
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPS 1300

Query: 562  QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEYRH 620
             + + L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+   
Sbjct: 1301 GTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKSPQ 1358

Query: 621  LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK--- 677
             L D G        +     S  P D++D +  L  D  S  S+  +  + AK +     
Sbjct: 1359 GLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418

Query: 678  --KAASSSKAPKNGGKAKDSAKTTEETSKPKD 707
              +A +S+ A +   K     + + E  +PKD
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 149/710 (20%), Positives = 259/710 (36%), Gaps = 152/710 (21%)

Query: 3    PTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTE 62
            PTE+     SQ+   P      K ++Q VKTE EK        V+ EK       KE   
Sbjct: 1140 PTESS----SQKTAVPPQVKLVKKQEQEVKTEAEK--------VILEKV------KETLS 1181

Query: 63   PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 122
             + +P   +     +    +    SA Q+      E K  P++      E    +     
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKP 1241

Query: 123  KPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL-------GGPEETEEEN- 174
             P DKK   ++ T A P E K D    KS +  A + L   +       G   +T+ E  
Sbjct: 1242 TPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL 1298

Query: 175  ---TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLAKKEGITGPPADSSKPI 226
               T  + P+  D  + T  E+       K +   P K +    +KE      + S +P 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---TEKEDDKSDTSSSQQPK 1355

Query: 227  GPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQSAGTVRSAAPPQEKKRK 280
             P    D   SSD   G  ++ G+      T++++  + LK  S     S + P +   K
Sbjct: 1356 SPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLA-K 1411

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAKAKEEKLEKCGEDDETI 335
            +E   +S   LEA +++L   ++E +     +     K+ ++ ++  E LE    ++E  
Sbjct: 1412 LESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIK 1469

Query: 336  PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 395
             S+   K    KD +  +P  ++    + +SE +D+++             +P +  EES
Sbjct: 1470 ESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR----------REPYDSVEES 1516

Query: 396  KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 455
              +  +PV +   RTS+ S  S                                      
Sbjct: 1517 SESENSPVPQRKRRTSVGSSSS-------------------------------------- 1538

Query: 456  DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 515
                ++ K+ED +  GE+E+ I     +E   D+D                 ++F+ + L
Sbjct: 1539 ----DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQL 1582

Query: 516  SEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKL 574
             E  S  ++    + +   K+ A     +++  +++    A  R  S  D+D D+A D+ 
Sbjct: 1583 KEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE- 1639

Query: 575  SDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNG 626
            S  L  R+    E+   E+ V        R K  E + TI  +Y          L  D  
Sbjct: 1640 SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEE 1696

Query: 627  QDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDSCPS 663
             +  ++  T   ED  +             P      + +L  D DS PS
Sbjct: 1697 PELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 246 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 292
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 293 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 343
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610

Query: 344 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 402
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669

Query: 403 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 460
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711

Query: 461 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 509
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771

Query: 510 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 564
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827

Query: 565 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 605
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 233 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 290
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445

Query: 291 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 341
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 342 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 391
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565

Query: 392 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 451
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619

Query: 452 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 511
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671

Query: 512 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 571
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722

Query: 572 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 602
                   ++  D  E K  E  VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 85/378 (22%), Positives = 150/378 (39%), Gaps = 56/378 (14%)

Query: 6   TKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS 65
           T+ + VS + E      +K+ + +A + E   K    K +   E K +EG+ +E  E   
Sbjct: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK-ATAPEVKEEEGEKEE--EEGQ 533

Query: 66  LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPG 125
             ++  D G        A S  AE+  SEK  E  ++ ++     GE+ A      G+  
Sbjct: 534 EEEEEEDEG--------AKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGEEA 580

Query: 126 DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 185
           + K+EKK       VE K ++ + K                 EE   +       +   P
Sbjct: 581 EAKEEKK-------VEEKSEEVATK-----------------EELVADAKVEKPEKAKSP 616

Query: 186 MSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT 245
           +  + +EE GK  V  P    E   K      P  +  K   P   ++         SP 
Sbjct: 617 VPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 674

Query: 246 AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 305
               K+   +S  V +A+S   V      +E++++V K+   ++ +E        ++ E 
Sbjct: 675 EEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKEEK 724

Query: 306 ELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSE 365
             D+   K+  E+  KEE + +     +++  +  L+  T ++GKPL  E +EK K   E
Sbjct: 725 PKDVPEKKKA-ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAGGE 780

Query: 366 SELIDELSEDFDRSECKE 383
               +E S+   +   KE
Sbjct: 781 GGSEEEGSDKGAKGSRKE 798



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 22/175 (12%)

Query: 18  PHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND 77
           P  P ++K K    K+  E+K +S       E+K++   PK   E      +       +
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE 703

Query: 78  AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS------------- 121
              K+      E++  +K  +PK  P+   +      E+VA +  I+             
Sbjct: 704 EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763

Query: 122 -GKP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 173
            GKP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 764 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 815


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 246 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 292
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 293 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 343
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234

Query: 344 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 402
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293

Query: 403 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 460
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335

Query: 461 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 509
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395

Query: 510 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 564
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451

Query: 565 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 605
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 233 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 290
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 10  DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69

Query: 291 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 341
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 70  LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129

Query: 342 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 391
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189

Query: 392 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 451
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243

Query: 452 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 511
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295

Query: 512 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 571
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346

Query: 572 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 602
                   ++  D  E K  E  VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 85/378 (22%), Positives = 150/378 (39%), Gaps = 56/378 (14%)

Query: 6   TKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS 65
           T+ + VS + E      +K+ + +A + E   K    K +   E K +EG+ +E  E   
Sbjct: 101 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK-ATAPEVKEEEGEKEE--EEGQ 157

Query: 66  LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPG 125
             ++  D G        A S  AE+  SEK  E  ++ ++     GE+ A      G+  
Sbjct: 158 EEEEEEDEG--------AKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGEEA 204

Query: 126 DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 185
           + K+EKK       VE K ++ + K                 EE   +       +   P
Sbjct: 205 EAKEEKK-------VEEKSEEVATK-----------------EELVADAKVEKPEKAKSP 240

Query: 186 MSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT 245
           +  + +EE GK  V  P    E   K      P  +  K   P   ++         SP 
Sbjct: 241 VPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298

Query: 246 AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 305
               K+   +S  V +A+S   V      +E++++V K+   ++ +E        ++ E 
Sbjct: 299 EEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKEEK 348

Query: 306 ELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSE 365
             D+   K+  E+  KEE + +     +++  +  L+  T ++GKPL  E +EK K   E
Sbjct: 349 PKDVPEKKKA-ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAGGE 404

Query: 366 SELIDELSEDFDRSECKE 383
               +E S+   +   KE
Sbjct: 405 GGSEEEGSDKGAKGSRKE 422



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 22/175 (12%)

Query: 18  PHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND 77
           P  P ++K K    K+  E+K +S       E+K++   PK   E      +       +
Sbjct: 268 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE 327

Query: 78  AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS------------- 121
              K+      E++  +K  +PK  P+   +      E+VA +  I+             
Sbjct: 328 EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387

Query: 122 -GKP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 173
            GKP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 388 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 439


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 131/612 (21%), Positives = 228/612 (37%), Gaps = 94/612 (15%)

Query: 5   ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK------ 58
           ET A+  ++  E       KK K Q  K +    + S +L     K  +  KPK      
Sbjct: 77  ETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSG 136

Query: 59  --EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV-A 115
             +  +   LPK+A   G     NKK      ++  S+K      K +  I++ GES   
Sbjct: 137 SDDDDDFNKLPKKAK--GKAQKSNKKWDGSEEDEDNSKK-----IKERSRINSSGESGDE 189

Query: 116 GITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENT 175
               +  + G KK +K    P +   ++ D  S K          I T+   +  ++E  
Sbjct: 190 SDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFK----------IKTVAQKKAEKKERE 239

Query: 176 TYTGPEVSDPMSSTYIEE---LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAI 232
                E    +     +E    GK++ +   K +E   K E  T      SK       I
Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQS---KQKESQRKFEEETV----KSKVTVDTGVI 292

Query: 233 DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQA 290
            A  S+    +PTAA    E ++  +  K +           +EKK+   K T+    +A
Sbjct: 293 PA--SEEKAETPTAAEDDNEGDKKKKDKKKKKG---EKEEKEKEKKKGPSKATVKAMQEA 347

Query: 291 LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGK 350
           L  L      ++ E E  ++ ++E++  + +EE+LE+  + +     E   K    K+GK
Sbjct: 348 LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK 406

Query: 351 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
            LL + + + + R+E+ L    ++  +       P K     ++ +   P  +       
Sbjct: 407 -LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465

Query: 411 SM--CSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDRE 468
           SM  C+                  AVE +   + +KE  P   +P  ++  E A  +D E
Sbjct: 466 SMELCA------------------AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507

Query: 469 KLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSL 528
            +   EET   +     ++ K+     P+E +E+     ED   +   E+  G    S  
Sbjct: 508 AMASDEETEKVEGNKVHIEVKEN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEG 562

Query: 529 KFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN 588
             ED K++                      D   S K LD    K   S    + D D++
Sbjct: 563 DEEDEKVS----------------------DEKDSGKTLDKKPSKEMSS--DSEYDSDDD 598

Query: 589 KPMEDKVKEKAK 600
           +  E++  +KAK
Sbjct: 599 RTKEERAYDKAK 610



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 123/651 (18%), Positives = 238/651 (36%), Gaps = 110/651 (16%)

Query: 49  EKKSQEGKPKEHTEPKSLPKQASDTGS--NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 106
           +K   E   K+  +  +L  +    G+       K    +  E++  +   +   K  + 
Sbjct: 5   QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64

Query: 107 ISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 165
           +S   + + A    ++ KP +  +E+ +        SK  K  G+ G   + DD      
Sbjct: 65  LSLEAQGIKADRETVAVKPTENNEEEFT--------SKDKKKKGQKGKKQSFDD-----N 111

Query: 166 GPEETEEENTTY---TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADS 222
             EE E++++       P+V     S   ++  K       K ++   K +G +    D+
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-SEEDEDN 170

Query: 223 SKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 282
           SK I     I++              +K +K+      K +    + S     +   K++
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ----KNKPGPNIESGNEDDDASFKIK 226

Query: 283 KDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 342
             T++ +  E        R  E +  LR +KE +E +  ++   K  E       E    
Sbjct: 227 --TVAQKKAEKKERERKKRDEE-KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS 283

Query: 343 PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP 402
             T   G  ++P  EEK +  + +E  D+   D  + + K+K  +  EK +E K      
Sbjct: 284 KVTVDTG--VIPASEEKAETPTAAE--DDNEGDKKKKDKKKKKGEKEEKEKEKKKG---- 335

Query: 403 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKA 462
                            P  AT+K     +A+  L +   +++ + E+    +++++ K 
Sbjct: 336 -----------------PSKATVKAM--QEALAKLKEEEERQKREEEERIKRLEELEAKR 376

Query: 463 KEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE----------------------SK 500
           KEE+R +  ++E     +   +E   K+GK L   +                      SK
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436

Query: 501 EQLP---PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS--TTQAGA 555
           + LP   P+ ED     + +     + + S++     L AA+  +    P    T     
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPPVE 491

Query: 556 PPRDTSQSDKDLDDALDKLSDSLGQR---------------QPDPDENKPMEDKVKEKAK 600
           P  +    D  LDD     SD   ++               + + +E +  ED+  E+ +
Sbjct: 492 PEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEE 551

Query: 601 AEHRDKLG----ERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 647
            E  +  G    E D+ +  E      D+G+    KP  + S DS+  +DD
Sbjct: 552 EEEGESEGSEGDEEDEKVSDE-----KDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 92/424 (21%), Positives = 162/424 (38%), Gaps = 53/424 (12%)

Query: 22  NKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQ--EGKPKEHTEPKSL-----PKQASDTG 74
           N+K      +++  E    S K+  V +KK++  E + K+  E K+       K+  +TG
Sbjct: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETG 262

Query: 75  SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG-KPGDKKKEKKS 133
             D   +K   R  E++  +      T    +I A  E     TA      GDKKK+ K 
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDT---GVIPASEEKAETPTAAEDDNEGDKKKKDKK 319

Query: 134 LTPAVPVESKPDKPSGKSGMDA-ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 192
                  E + +K  G S     A+ + +  L   EE ++         + +  +    E
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEE 379

Query: 193 ELGKREVTIPPKYRE------------LLAKKEGITGPPADSSKPIGPDDAIDALSSD-F 239
           E  ++E     K +E            LL K +      A+++  +     ++  S D  
Sbjct: 380 ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSL 439

Query: 240 TCGSPTAAGKKTEK----------EESTEVLKA-----QSAGTVRSAAPPQEKKRKVEKD 284
               P    KK +K           ES E+  A     Q         PP E + + + +
Sbjct: 440 PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499

Query: 285 TMSDQALEALSASLGTRQAE-----------PELDLRSIKEVDEAKAKEEKLEKCGEDDE 333
                  EA+++   T + E           PE +    +E +E +  EE+ E+ GE + 
Sbjct: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG 559

Query: 334 TIPSEYRLKPATDKD-GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 392
           +   E   K + +KD GK L  +P ++    SE +  D+ +++ +R+  K K      + 
Sbjct: 560 SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRL 618

Query: 393 EESK 396
           E SK
Sbjct: 619 EHSK 622



 Score = 37.0 bits (84), Expect = 0.063
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)

Query: 559 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 618
           D+++ D DLD    ++  +   ++ +P ++K  + K K+K   +  D L E ++ +  E 
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69

Query: 619 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 667
           + +            ++N ++   K   KK +  KK + D +  + L  D DS       
Sbjct: 70  QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122

Query: 668 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 708
           S+ TAK K +  + S      +K PK   GKA+ S K  + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170


>gi|109637791 transcription factor-like nuclear regulator [Homo
            sapiens]
          Length = 2624

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 128/601 (21%), Positives = 227/601 (37%), Gaps = 89/601 (14%)

Query: 22   NKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 81
            +K  H K +V+    +K +   L ++  + ++   P+  T      K     GS     +
Sbjct: 641  SKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALR 700

Query: 82   KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 141
                R   Q+P   + +   + + +IS   E  A +         +K E +S        
Sbjct: 701  PVQVRGRLQKPKPNAGKAAERKEILISQE-EIGANV---------EKNENESCAD----R 746

Query: 142  SKPDKPSGKSGMDAALDDLIDTLGGPEETEE-ENTTYTGPEVSDPMSSTYIEELGKREVT 200
              P     +S  D   +D+I     PE+ +  +N     P+V +   S        +   
Sbjct: 747  DTPQHMEDQSRKDFEEEDVILQ---PEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQ 803

Query: 201  IPPKYRELLAKKEGI---TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEK---- 253
            +P         K  I   TG    SSK        + L      G   AA ++T +    
Sbjct: 804  VPILRTRFQKPKPNIGRGTGRREISSKE-------EVLEKILVSGEMAAALRETVRLDTS 856

Query: 254  -------EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS-DQALEALSASLGTRQAEP 305
                   E +T+ +++    T R A  P+EK   V  DT+  +  L+A+   +  R+  P
Sbjct: 857  PKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTP 916

Query: 306  ELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSE 365
            E+       +D  +  ++ LE+ G          R + +  K+G      PEE  KP  E
Sbjct: 917  EV-------IDATEEIDKDLEEAG----------RREISPQKNG------PEEV-KPLGE 952

Query: 366  SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 425
             E   +L    + S  +EK  + T+ TEE        + + +  T    I      P  +
Sbjct: 953  VET--DLKATGNESSPREKTPEVTDATEE--------IDKNLEETGRRKISPRENGPEEV 1002

Query: 426  KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 485
            K   P D +E   ++ G++ +  E    V+D  +E   EE       + E  P +  LEE
Sbjct: 1003 K---PVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET------EREVSPQENGLEE 1053

Query: 486  VKDK-DGKPLLPKESKEQLPPMSEDFLLDALSE---DFSGPQNASSLKFEDAKLAAAISE 541
            VK   + +  L    ++  P      ++DA+ E   D    +   S +    +    + E
Sbjct: 1054 VKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGE 1113

Query: 542  VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKA 601
            +  QT    T     PR+ +    D  + +DK  +  G+R+  P+EN P E K  ++ + 
Sbjct: 1114 M--QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMET 1171

Query: 602  E 602
            +
Sbjct: 1172 D 1172


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 127/605 (20%), Positives = 216/605 (35%), Gaps = 128/605 (21%)

Query: 21  PNKKKHKKQAVKTEPEKKSQSTK-LSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 79
           P  KK KK+A  ++ E  S+  + +     KK+     +    P     +AS++ S++  
Sbjct: 73  PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132

Query: 80  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-V 138
           +        ++QP +K  +P+ K         +S    +  S +    K +K  +TP  V
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192

Query: 139 PVESK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 192
             ++K P KP+  +     G  A+      +    +++EEE    T  +           
Sbjct: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKK----------- 241

Query: 193 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 252
                  T+P K  +++AK      P   ++ P     + +  SSD             E
Sbjct: 242 -------TVPKK--QVVAK-----APVKAATTPTRKSSSSEDSSSD-------------E 274

Query: 253 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 312
           +EE  + +K    G   S  PP     K                SLGT+  +        
Sbjct: 275 EEEQKKPMK-NKPGPYSSVPPPSAPPPK---------------KSLGTQPPK-------- 310

Query: 313 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 372
           K V++ +  E   +   E D +  SE   KP T    K ++ +   KP P  ++      
Sbjct: 311 KAVEKQQPVESSEDSSDESDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAAESSSD 364

Query: 373 SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 432
           S D D SE  E PSKP   T+ S +  PA  +++               PA      P  
Sbjct: 365 SSDSDSSEDDEAPSKPAGTTKNS-SNKPAVTTKS---------------PAVKPAAAPKQ 408

Query: 433 AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGK 492
            V                G+ ++ +  + +  E+     E+E+T      +   K K   
Sbjct: 409 PVGG--------------GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTKPKATA 451

Query: 493 PLLPKESKEQLPPMSEDFLLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 549
                   +Q P  S D   D   + SE+     + S++K +  K+A          PAS
Sbjct: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPAS 508

Query: 550 TTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN-------------KPMEDKVK 596
             +  A   ++S SD   ++  +KL      R   P  N             K  E++ +
Sbjct: 509 AKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEE 568

Query: 597 EKAKA 601
           EK KA
Sbjct: 569 EKKKA 573



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)

Query: 378 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 437
           +++ K   S   + +EE +     P  +A        +   PP  A  K +    + E+ 
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133

Query: 438 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 495
            D       D ED K  PV   VK +AK         K      D   E+   K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 496 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 544
                      P +     P ++      A S   S   ++SS   E+ K AA   + V 
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244

Query: 545 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 588
           +      A    A  P R +S S+    D  ++    +  +            P P ++ 
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304

Query: 589 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 642
             +P +  V+++   E  +   +  D+   E +      +      KP  PP KK+ +S 
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362

Query: 643 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 690
             + D D     S + D  PS    TT+ S N    T K    K A++ K P  GG    
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 691 -KAKDSAKTTEETSKPKDD 708
            +  DS+ + EE+S  +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 104/475 (21%), Positives = 176/475 (37%), Gaps = 55/475 (11%)

Query: 3   PTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK-KSQSTKLSVVHEKKSQEGKPKEHT 61
           P +    P ++  + P    K         +E E  K+Q  K++ V  K   +  PK   
Sbjct: 145 PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPK--- 201

Query: 62  EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEP-KTKPQDMISAGGESVAGIT-- 118
             ++ PK A+   ++ + +  + S S + +  + +  P KT P+  + A     A  T  
Sbjct: 202 PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPT 261

Query: 119 ----AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 174
               +      D+++E+K      P+++KP   S      A           P++  E+ 
Sbjct: 262 RKSSSSEDSSSDEEEEQKK-----PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316

Query: 175 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA 234
                 E S   S +  EE  K      P  + +++K    T PP          D+ D+
Sbjct: 317 QPVESSEDSSDESDSSSEEEKK------PPTKAVVSK--ATTKPPPAKKAAESSSDSSDS 368

Query: 235 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 294
            SS+        AG  T K  S +      +  V+ AA P++     +K           
Sbjct: 369 DSSEDDEAPSKPAG--TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK----------- 415

Query: 295 SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP 354
              L TR+A+      S  E + + ++EEK +K      T   +   K A     K   P
Sbjct: 416 ---LLTRKAD-----SSSSEEESSSSEEEKTKKM---VATTKPKATAKAALSLPAKQ-AP 463

Query: 355 EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCS 414
           +        S+S   +E  E   +S  K+KP K       SK A+ A   +A    S  S
Sbjct: 464 QGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPAS-AKKGKAESSNSSSS 522

Query: 415 IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 469
             S+  E   LKG          A+  G      ++GK   +  +E   EE+++K
Sbjct: 523 DDSSEEEEEKLKGKGSPRPQAPKAN--GTSALTAQNGKAAKNSEEE---EEEKKK 572



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 72/390 (18%), Positives = 140/390 (35%), Gaps = 65/390 (16%)

Query: 22  NKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN- 80
           ++++ +K+ +K +P   S     S    KKS   +P +    K  P ++S+  S+++ + 
Sbjct: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSS 332

Query: 81  ---------KKAVSRSAEQQP-SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 130
                    K  VS++  + P ++K+ E  +   D  S+  +      A + K    K  
Sbjct: 333 SEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA 392

Query: 131 KKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTY 190
             + +PAV   + P +P G          L+        +EEE+++    +    +++T 
Sbjct: 393 VTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446

Query: 191 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 250
            +   K  +++P K                    P G  D+    SSD    S     +K
Sbjct: 447 PKATAKAALSLPAK------------------QAPQGSRDS----SSDSDSSSSEEEEEK 484

Query: 251 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR 310
           T K  + +    + AG    + P   KK K E    S                       
Sbjct: 485 TSKS-AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD-------------------- 523

Query: 311 SIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 370
                D ++ +EEKL+  G      P        T ++GK      EE+ + +  + ++ 
Sbjct: 524 -----DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVS 578

Query: 371 ELSEDFDRSECKEKPSKPTEKTEESKAAAP 400
           +      R + +      T + ++ K   P
Sbjct: 579 KSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 87/397 (21%), Positives = 148/397 (37%), Gaps = 60/397 (15%)

Query: 12  SQQMEGPHLPNKKKHKKQAVK-------TEPEKKSQSTKLSVVHE----KKSQEGKPKEH 60
           S++ +    P K   KKQ V        T P +KS S++ S   E    KK  + KP  +
Sbjct: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY 289

Query: 61  ----------------TEP--KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-- 100
                           T+P  K++ KQ     S D+ ++   S   E++P  K+   K  
Sbjct: 290 SSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349

Query: 101 TKP-------------QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 147
           TKP              D  S+  +      A + K    K    + +PAV   + P +P
Sbjct: 350 TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP 409

Query: 148 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 207
            G          L+        +EEE+++    +    +++T  +   K  +++P K   
Sbjct: 410 VGGG------QKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAK--- 460

Query: 208 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP--TAAGKKTEKEESTEVLKAQSA 265
                +G     +DS      ++  +  S       P   A G    K  S +  KA+S+
Sbjct: 461 --QAPQGSRDSSSDSDSSSSEEEE-EKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517

Query: 266 GTVRSAAPPQEKKRKVE-KDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 324
            +  S    +E++ K++ K +   QA +A   S  T Q   +    S +E +E K     
Sbjct: 518 NSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQ-NGKAAKNSEEEEEEKKKAAVV 576

Query: 325 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 361
           + K G   +   +E   +  T +  K  L  P   PK
Sbjct: 577 VSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPK 613


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 105/533 (19%), Positives = 189/533 (35%), Gaps = 82/533 (15%)

Query: 219 PADSSKPI-----GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 273
           P  +S+P      G D++ D  SS    GS +++G  +E E S+   +A       S  P
Sbjct: 407 PGSNSEPSHHNSEGADNSRDDSSSH--SGSESSSGSDSESESSSSDSEANEPSQSASPEP 464

Query: 274 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 333
                 K + D   ++        +   +  P   + S     +   KE + +  G    
Sbjct: 465 EPPPTNKWQLDNWLNK--------VNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNS-- 514

Query: 334 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 393
                      TD  G    P+      P  +S+ I + SE     +     S  T +  
Sbjct: 515 ----------YTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRR 560

Query: 394 ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEADPED 450
                 P    +A        ++     P  L  ++P    +A      K   K+     
Sbjct: 561 TVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSS 620

Query: 451 GKPVMDKVKEKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPLLPKE 498
            +P  +K K K+  +  +K  E            + E++PP  +  +  + +  P+ P  
Sbjct: 621 PRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSS 680

Query: 499 SKEQ--------LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVSQT-P 547
            +E+          PM E  LL  LSE    P +   L  K +   L     +   +T P
Sbjct: 681 VEEEDSFFRQRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYKETEP 736

Query: 548 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKL 607
               +   P + T ++ K    A +K+S+   ++  + D+N+  E K   K K E ++  
Sbjct: 737 PKGEKKNVPEKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSA 790

Query: 608 GERDDT-------IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
           G +  +          + + LL       P K P  +    K+       + + S     
Sbjct: 791 GHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKE 850

Query: 661 CPSTTETSQNTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 706
              +++ S +T+K K  +  +SS       KAP +      SA T  ++SKP+
Sbjct: 851 TSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 118/581 (20%), Positives = 197/581 (33%), Gaps = 128/581 (22%)

Query: 52  SQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK-STEPKTKPQDMISAG 110
           + EG      +  S     S +GS D+ ++ + S S   +PS+  S EP+  P +     
Sbjct: 417 NSEGADNSRDDSSSHSGSESSSGS-DSESESSSSDSEANEPSQSASPEPEPPPTNKWQLD 475

Query: 111 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG--KSGMDAALDDLIDTLGGPE 168
                            K     ++PA  V+S      G  K G +    +      GP+
Sbjct: 476 NWL-------------NKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPK 522

Query: 169 ET------EEENTTYTGPE--------VSDPMSSTYIEELGKREVTIPPKYRELLAKKEG 214
           ET       +  T   G E         +   S+T    +GK++    PK  E  A +E 
Sbjct: 523 ETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ----PKKAEKAAAEEP 578

Query: 215 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 274
             G   +S  P+           D     P++  K   K      +K +S    +S+  P
Sbjct: 579 RGGLKIESETPV-----------DLASSMPSSRHKAATKGSRKPNIKKES----KSSPRP 623

Query: 275 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 334
             +K+K +  + S Q                    R I E D + +         ++ E+
Sbjct: 624 TAEKKKYKSTSKSSQ------------------KSREIIETDTSSSD-------SDESES 658

Query: 335 IPSEYRLKPATDKDGKPLLPEPEEKP---------KPRSESELIDELSEDFDRSECKEK- 384
           +P   +     + +  P+ P   E+           P  E EL+  LSE  DR     K 
Sbjct: 659 LPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKI 718

Query: 385 --------PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEA 436
                   P KP ++TE  K                   +   PE  T +      A E 
Sbjct: 719 DLNLLTRIPGKPYKETEPPKGE-----------------KKNVPEKHTRE--AQKQASEK 759

Query: 437 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD--GKPL 494
           +++   +K  + +D +    K   K K ED+   G K  +     +    K+KD    P 
Sbjct: 760 VSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPA 816

Query: 495 LPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAG 554
            P  SK+  P          +S+  S   +++S K              S+  +ST++  
Sbjct: 817 GPVPSKD--PKTEHGSRKRTISQSSSLKSSSNSNKETSGS---------SKNSSSTSKQK 865

Query: 555 APPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 595
                TS S K++ +     S +     P  D +KP   K+
Sbjct: 866 KTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 98/422 (23%), Positives = 160/422 (37%), Gaps = 67/422 (15%)

Query: 35  PEKKSQST--KLSVVHEKKSQEGKPKEHTEPKS-LPKQASDTGSNDAHNKKAVSRSAEQQ 91
           P++ S +T  + S   +K S+ G+ ++ +  +S    Q    G      KKA   +AE+ 
Sbjct: 521 PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQP--KKAEKAAAEEP 578

Query: 92  PSEKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 150
                 E +T P D+ S+   S     T  S KP  KK+ K S  P    E K  K + K
Sbjct: 579 RGGLKIESET-PVDLASSMPSSRHKAATKGSRKPNIKKESKSS--PRPTAEKKKYKSTSK 635

Query: 151 SGMDAALDDLIDTLGGPEETEEENT------TYTGPEVS-DPMSSTYIEE---LGKREVT 200
           S   +   ++I+T     +++E  +      T   PE +  P+  + +EE     ++ + 
Sbjct: 636 SSQKSR--EIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMF 693

Query: 201 IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 260
            P + +ELL          +  S+P      I  +  +     P    K+TE        
Sbjct: 694 SPMEEKELL----------SPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETE-------- 735

Query: 261 KAQSAGTVRSAAPPQEKKRKVEKDT--MSDQALEALSASLGTRQAEPELDLRSIKEVDEA 318
                       P  EKK   EK T     QA E +S + G R+ + E D R+    +  
Sbjct: 736 -----------PPKGEKKNVPEKHTREAQKQASEKVS-NKGKRKHKNEDDNRA---SESK 780

Query: 319 KAKEEKLEKCGEDDETIPSEYRLKPATDKD--GKPLLPEPEEKPKPR--------SESEL 368
           K K E     G    +     +   A +KD    P  P P + PK          S+S  
Sbjct: 781 KPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSS 840

Query: 369 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT 428
           +   S     +    K S  T K ++++    +  S+ V   +  S  + PP   TL  +
Sbjct: 841 LKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSS-SKEVKEKAPSSSSNCPPSAPTLDSS 899

Query: 429 VP 430
            P
Sbjct: 900 KP 901


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 150/725 (20%), Positives = 258/725 (35%), Gaps = 133/725 (18%)

Query: 13   QQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASD 72
            ++ +GP    K+K K +  K +   K +S K S++ + +  +   K   E K   ++  D
Sbjct: 1010 EKKDGPDKERKEKTKPERYKEKSSDKDKSEK-SILEKCQKDKEFDKCFKEKKDTKEKHKD 1068

Query: 73   TGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKK 132
            T   D   K ++ +  E+   ++   P    +D               S K  DKK ++K
Sbjct: 1069 THGKDKERKASLDQGKEK---KEKAFPGIISED--------------FSEKKDDKKGKEK 1111

Query: 133  S--LTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST 189
            S  +      ES+ D+ S   SG        +    G +E EE    Y     SD    +
Sbjct: 1112 SWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAY----ASDRHRKS 1167

Query: 190  YIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 249
              ++  +R+    P+ R    K  G      D  + +                      K
Sbjct: 1168 SDKQHPERQKDKEPRDRR---KDRGAADAGRDKKEKV------------------FEKHK 1206

Query: 250  KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE--L 307
            + + +ESTE  K +       +   ++ K+K+ +      A E  + S    +++ E   
Sbjct: 1207 EKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSK 1266

Query: 308  DLRSIKEVDEAKA-----KEEKLEKCGEDDETIPSEYRLKPATDKDGKPLL--------P 354
            + +S +  D  K+     +EE L +  ED     SE      TD+  +P L         
Sbjct: 1267 ERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFT 1326

Query: 355  EPEEKPKPRSESELIDELSE-------------DFDRSECKEKPSKPTEKTEESKAAAPA 401
            EP    KPR  + L ++L E               DR   K++ ++  EK E+ K     
Sbjct: 1327 EPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSR 1386

Query: 402  PVS------------EAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK--KEAD 447
              S              V       I+    +   L  T   D  ++  +   K  KE  
Sbjct: 1387 KDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELK 1446

Query: 448  PEDGKPVMDKVKEKAKEEDREKLGEKEETIPP-------------------DYRLEEVKD 488
            P     +    ++K +E+ REK  +++E                       D +    +D
Sbjct: 1447 PYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRD 1506

Query: 489  KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 548
            KD  P + K+      P   D  L    +D +  +    +K  +     A S+       
Sbjct: 1507 KDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSK------- 1559

Query: 549  STTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE-NKPMEDKVKEKAKAEHRD-- 605
               +  A PR+    D DL   +      L Q+  + +E +K  ++++K+  K  HR   
Sbjct: 1560 DPGKKDARPREKLLGDGDL--MMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD 1617

Query: 606  -KLGER----DD------TIPPEYRHLLDDNGQDKPVK---PPTKKSEDSKKPADDQDPI 651
             KL E+    DD       IP +    LD   +DK +K   P    +E+   PA   D  
Sbjct: 1618 PKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSK 1677

Query: 652  DALSG 656
            D L+G
Sbjct: 1678 DWLAG 1682



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 108/513 (21%), Positives = 189/513 (36%), Gaps = 59/513 (11%)

Query: 230  DAIDALSSDFTCGSPTAAGKKTEKEESTEV-----LKAQSAGTVRSAAPPQEKKRKV-EK 283
            D  DAL S        A  ++  +EE  E       K +S G       P E+     EK
Sbjct: 950  DRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREK 1009

Query: 284  DTMSDQALEALSASLGTRQAEPELDL-RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 342
            +       E    +   R  E   D  +S K + E   K+++ +KC ++ +    +++  
Sbjct: 1010 EKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDT 1069

Query: 343  PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEK----PSKPTEKTEESKAA 398
               DK+ K  L + +EK +      + ++ SE  D  + KEK        T+++E+ + +
Sbjct: 1070 HGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDS 1129

Query: 399  APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADP-----EDGKP 453
                     C  S   +  A   P T      ++  EA A    +K +D      +  K 
Sbjct: 1130 ---------CMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKE 1180

Query: 454  VMDKVKEK----AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPP 505
              D+ K++    A  + +EK+ EK +        E+ KD+  +  +     K++K++LP 
Sbjct: 1181 PRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPE 1240

Query: 506  MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 565
             +E       +ED +  ++      E +K      E  S   A   ++     +     +
Sbjct: 1241 KAEK---KHAAEDKAKSKHKEKSDKEHSK------ERKSSRSADAEKSLLEKLEEEALHE 1291

Query: 566  DLDDALDKL----SDSLGQRQPDPD---------ENKPMEDKVKEKAKAEHRDKLGERDD 612
              +D+ DK+    SDS   R  +P             P +DK +E A    + K  ER  
Sbjct: 1292 YREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHR 1351

Query: 613  TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD----PIDALSGDLDSCPSTTETS 668
                  +   D     K      +K ED K+    +D      D L  D        +  
Sbjct: 1352 HSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKAD 1411

Query: 669  QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 701
                 DK  +  S+ K  KN  + + S K  +E
Sbjct: 1412 IEDELDKTIELFSTEKKDKNDSEREPSKKIEKE 1444



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 93/418 (22%), Positives = 163/418 (38%), Gaps = 57/418 (13%)

Query: 262 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 321
           +    +V S  P ++++   ++ ++S++    LS++ G   A P+LD    K V + K K
Sbjct: 580 SSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEG---AVPKLDKEG-KVVKKHKTK 635

Query: 322 EEKLEKCGEDDETIPSEYRLKPAT-------DKDGKPLLPEPEEKPKPRSESELIDELSE 374
            +   K  +   +I  E +LK  T        K  K +L E +      S    +  L  
Sbjct: 636 HKHKNK-EKGQCSISQELKLKSFTYEYEDSKQKSDKAILLEND-----LSTENKLKVLKH 689

Query: 375 DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 434
           D D  + +EK SK   K EE +       S    + +   I  +  E          D  
Sbjct: 690 DRDHFKKEEKLSKM--KLEEKEWLFKDEKSLKRIKDTNKDISRSFREEK--------DRS 739

Query: 435 EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL 494
                    KE  P++ K  + K + K K +DR    EK+  +  D ++ + K+K     
Sbjct: 740 NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKED-KISKEKEK----- 793

Query: 495 LPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAG 554
           + KE KE+L    + +  D+  +++        L+ ED K + +  +   +  +  + + 
Sbjct: 794 IFKEDKEKL-KKEKVYREDSAFDEYCNKN--QFLENEDTKFSLS-DDQRDRWFSDLSDSS 849

Query: 555 APPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD-KLGERDDT 613
              +     D  + D  D  SDS+          K + + VKE +K   RD +  E+ D 
Sbjct: 850 FDFKGEDSWDSPVTDYRDMKSDSVA---------KLILETVKEDSKERRRDSRAREKRDY 900

Query: 614 IPPEY----RHLLDDNGQ------DKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSC 661
             P +    R  LD N +      +K    P   SE  KK  +  +        L+SC
Sbjct: 901 REPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESC 958



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 63/267 (23%), Positives = 104/267 (38%), Gaps = 45/267 (16%)

Query: 89   EQQPSEKSTEPKTKPQDMISAGGESVAG---ITAISGKPGDKKKEKKSLTPAVPVESKPD 145
            E +P E+S  P   P++M       + G    T ++ +P     ++ S    +P E +P+
Sbjct: 2152 EAEPVEESLAP---PEEMPPGAPGVINGGDVSTVVAEEPPALPPDQASTR--LPAELEPE 2206

Query: 146  KPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKY 205
             PSG+  +D AL+  ++    PEE              DP SS            +PP+ 
Sbjct: 2207 -PSGEPKLDVALEAAVEAETVPEERAR----------GDPDSSV-------EPAPVPPEQ 2248

Query: 206  RELLAKKEG--ITGPPADS-SKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 262
            R L +  +G    GPPA S   P GP     A ++     +   AG + + E S     A
Sbjct: 2249 RPLGSGDQGAEAEGPPAASLCAPDGP-----APNTVAQAQAADGAGPEDDTEASRAAAPA 2303

Query: 263  QS--AGTVRSAAPPQ-----EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 315
            +    G    AA P+      K  +VE+         A   +  ++Q  P     S KE 
Sbjct: 2304 EGPPGGIQPEAAEPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPP----SEKEC 2359

Query: 316  DEAKAKEEKLEKCGEDDETIPSEYRLK 342
                A   + +  G +D+   +++  K
Sbjct: 2360 APTPAPVTRAKARGSEDDDAQAQHPRK 2386


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 152/755 (20%), Positives = 245/755 (32%), Gaps = 87/755 (11%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK--- 58
           +P  T A P++ +   P  PN    K+ ++    E   ++ + +  +++ S +GK K   
Sbjct: 115 SPKITTAKPINPRPSLP--PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS 172

Query: 59  -------EHTEPKSL-----------PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 100
                  E T  K L           PK  + T        K  + +  ++P+  ST PK
Sbjct: 173 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA--STTPK 230

Query: 101 TKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLTPAVPVESKPDKPSG-- 149
                 I +     +  A  T  S     K+      KE    TP  P  +   +P+   
Sbjct: 231 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 290

Query: 150 -KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 208
            KS      +    T   P  T  +    T P+   P +        K      PK    
Sbjct: 291 TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 350

Query: 209 LAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 268
            A K+     P + + P  P +     + + +  +P      T K   T   +     T 
Sbjct: 351 TAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 409

Query: 269 RSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 324
            +   P+E      K+    T  + A         T   EP     + KE      K+  
Sbjct: 410 SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPA 467

Query: 325 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRS 379
                E   T P E    P T K   P  PE       EKP P +  EL     E+    
Sbjct: 468 PTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE---- 521

Query: 380 ECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEA 436
                P+ P E    + KAAAP    E    T      + P EPA  T K T P    + 
Sbjct: 522 ---PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KG 577

Query: 437 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
            A +  K+ A     KP   ++     +E      +K     P         K   P  P
Sbjct: 578 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTP 628

Query: 497 KES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 551
           KE      KE  P   +      L E    P   +  K    +LA   ++  + T +   
Sbjct: 629 KEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKP 684

Query: 552 QAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 611
               P      + K+      K         P P  ++       ++    H+      D
Sbjct: 685 APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----D 740

Query: 612 DTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETS 668
           ++ P           ++ P +P  PT K+  + KP       D  +  DL + P TT  +
Sbjct: 741 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 800

Query: 669 QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 703
               K+       ++++       + ++ TT++T+
Sbjct: 801 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 835



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 224 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 282
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 283 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 341
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 342 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 398
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254

Query: 399 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 458
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 459 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 512
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374

Query: 513 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 569
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 570 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 628
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484

Query: 629 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 688
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542

Query: 689 GGKAKDSAKTTEETSKP 705
               K+ A TT +   P
Sbjct: 543 ---PKEPAPTTPKEPAP 556



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 216 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 275
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173

Query: 276 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 335
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233

Query: 336 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 383
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293

Query: 384 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 441
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 352

Query: 442 GKKEADPEDGKPVMDKVKEKAKEEDRE 468
            KK A     +P     KE A    +E
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKE 379



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 118/561 (21%), Positives = 191/561 (34%), Gaps = 93/561 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHK--KQAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE 59
            T  K  P + +   P  P K      ++   T PE+ + +T  + +    K +    PKE
Sbjct: 486  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 545

Query: 60   H--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 111
               T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++     
Sbjct: 546  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPTTT 604

Query: 112  ESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 167
            +     T     P    G      K   P  P E  P  P G +      +    T   P
Sbjct: 605  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKP 663

Query: 168  EETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 225
               E   TT  GP    SD  + T  +E      T P +      KK   T P       
Sbjct: 664  APKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET----- 715

Query: 226  IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRK 280
              P      +S+  T   PT   K  +  EST  L A+        +P     P  K   
Sbjct: 716  --PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPA 771

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY- 339
              K  M+  A +  +          E DLR+  E   A  K  K E     ++T  S+  
Sbjct: 772  ATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKIT 820

Query: 340  ----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 385
                ++   T +D  P          L P+     K  + +E++++           E+ 
Sbjct: 821  ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEET 870

Query: 386  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DA 433
            +KP ++   SKA  P P           S +              P P  +  T+P+ + 
Sbjct: 871  AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 930

Query: 434  VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKD 488
               +A+++ +    P    P    V+   K ED    G + ET      P  +  E   D
Sbjct: 931  TSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPD 987

Query: 489  KDGKPLLPKESKEQLPPMSED 509
             D  P +P +     P +S++
Sbjct: 988  MDYLPRVPNQGIIINPMLSDE 1008



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 460 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 519
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 38  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89

Query: 520 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 577
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 90  SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148

Query: 578 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 634
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208

Query: 635 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 690
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265

Query: 691 KAKDSAKTTEETSKP 705
             K+ A TT +   P
Sbjct: 266 TTKEPAPTTPKEPAP 280


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 152/755 (20%), Positives = 245/755 (32%), Gaps = 87/755 (11%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK--- 58
           +P  T A P++ +   P  PN    K+ ++    E   ++ + +  +++ S +GK K   
Sbjct: 156 SPKITTAKPINPRPSLP--PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS 213

Query: 59  -------EHTEPKSL-----------PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 100
                  E T  K L           PK  + T        K  + +  ++P+  ST PK
Sbjct: 214 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA--STTPK 271

Query: 101 TKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLTPAVPVESKPDKPSG-- 149
                 I +     +  A  T  S     K+      KE    TP  P  +   +P+   
Sbjct: 272 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 331

Query: 150 -KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 208
            KS      +    T   P  T  +    T P+   P +        K      PK    
Sbjct: 332 TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 391

Query: 209 LAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 268
            A K+     P + + P  P +     + + +  +P      T K   T   +     T 
Sbjct: 392 TAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 450

Query: 269 RSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 324
            +   P+E      K+    T  + A         T   EP     + KE      K+  
Sbjct: 451 SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPA 508

Query: 325 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRS 379
                E   T P E    P T K   P  PE       EKP P +  EL     E+    
Sbjct: 509 PTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE---- 562

Query: 380 ECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEA 436
                P+ P E    + KAAAP    E    T      + P EPA  T K T P    + 
Sbjct: 563 ---PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KG 618

Query: 437 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
            A +  K+ A     KP   ++     +E      +K     P         K   P  P
Sbjct: 619 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTP 669

Query: 497 KES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 551
           KE      KE  P   +      L E    P   +  K    +LA   ++  + T +   
Sbjct: 670 KEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKP 725

Query: 552 QAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 611
               P      + K+      K         P P  ++       ++    H+      D
Sbjct: 726 APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----D 781

Query: 612 DTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETS 668
           ++ P           ++ P +P  PT K+  + KP       D  +  DL + P TT  +
Sbjct: 782 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 841

Query: 669 QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 703
               K+       ++++       + ++ TT++T+
Sbjct: 842 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 876



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 224 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 282
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 283 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 341
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 342 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 398
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295

Query: 399 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 458
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 459 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 512
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415

Query: 513 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 569
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 570 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 628
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525

Query: 629 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 688
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583

Query: 689 GGKAKDSAKTTEETSKP 705
               K+ A TT +   P
Sbjct: 584 ---PKEPAPTTPKEPAP 597



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 216 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 275
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214

Query: 276 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 335
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274

Query: 336 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 383
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334

Query: 384 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 441
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 393

Query: 442 GKKEADPEDGKPVMDKVKEKAKEEDRE 468
            KK A     +P     KE A    +E
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKE 420



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 118/561 (21%), Positives = 191/561 (34%), Gaps = 93/561 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHK--KQAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE 59
            T  K  P + +   P  P K      ++   T PE+ + +T  + +    K +    PKE
Sbjct: 527  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 586

Query: 60   H--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 111
               T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++     
Sbjct: 587  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPTTT 645

Query: 112  ESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 167
            +     T     P    G      K   P  P E  P  P G +      +    T   P
Sbjct: 646  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKP 704

Query: 168  EETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 225
               E   TT  GP    SD  + T  +E      T P +      KK   T P       
Sbjct: 705  APKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET----- 756

Query: 226  IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRK 280
              P      +S+  T   PT   K  +  EST  L A+        +P     P  K   
Sbjct: 757  --PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPA 812

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY- 339
              K  M+  A +  +          E DLR+  E   A  K  K E     ++T  S+  
Sbjct: 813  ATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKIT 861

Query: 340  ----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 385
                ++   T +D  P          L P+     K  + +E++++           E+ 
Sbjct: 862  ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEET 911

Query: 386  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DA 433
            +KP ++   SKA  P P           S +              P P  +  T+P+ + 
Sbjct: 912  AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 971

Query: 434  VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKD 488
               +A+++ +    P    P    V+   K ED    G + ET      P  +  E   D
Sbjct: 972  TSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPD 1028

Query: 489  KDGKPLLPKESKEQLPPMSED 509
             D  P +P +     P +S++
Sbjct: 1029 MDYLPRVPNQGIIINPMLSDE 1049



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 460 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 519
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 79  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130

Query: 520 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 577
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189

Query: 578 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 634
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249

Query: 635 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 690
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306

Query: 691 KAKDSAKTTEETSKP 705
             K+ A TT +   P
Sbjct: 307 TTKEPAPTTPKEPAP 321


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 152/755 (20%), Positives = 245/755 (32%), Gaps = 87/755 (11%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK--- 58
           +P  T A P++ +   P  PN    K+ ++    E   ++ + +  +++ S +GK K   
Sbjct: 208 SPKITTAKPINPRPSLP--PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS 265

Query: 59  -------EHTEPKSL-----------PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 100
                  E T  K L           PK  + T        K  + +  ++P+  ST PK
Sbjct: 266 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA--STTPK 323

Query: 101 TKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLTPAVPVESKPDKPSG-- 149
                 I +     +  A  T  S     K+      KE    TP  P  +   +P+   
Sbjct: 324 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 383

Query: 150 -KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 208
            KS      +    T   P  T  +    T P+   P +        K      PK    
Sbjct: 384 TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 443

Query: 209 LAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 268
            A K+     P + + P  P +     + + +  +P      T K   T   +     T 
Sbjct: 444 TAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 502

Query: 269 RSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 324
            +   P+E      K+    T  + A         T   EP     + KE      K+  
Sbjct: 503 SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPA 560

Query: 325 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRS 379
                E   T P E    P T K   P  PE       EKP P +  EL     E+    
Sbjct: 561 PTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE---- 614

Query: 380 ECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEA 436
                P+ P E    + KAAAP    E    T      + P EPA  T K T P    + 
Sbjct: 615 ---PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KG 670

Query: 437 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
            A +  K+ A     KP   ++     +E      +K     P         K   P  P
Sbjct: 671 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTP 721

Query: 497 KES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 551
           KE      KE  P   +      L E    P   +  K    +LA   ++  + T +   
Sbjct: 722 KEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKP 777

Query: 552 QAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 611
               P      + K+      K         P P  ++       ++    H+      D
Sbjct: 778 APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----D 833

Query: 612 DTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETS 668
           ++ P           ++ P +P  PT K+  + KP       D  +  DL + P TT  +
Sbjct: 834 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 893

Query: 669 QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 703
               K+       ++++       + ++ TT++T+
Sbjct: 894 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 928



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 124/625 (19%), Positives = 209/625 (33%), Gaps = 60/625 (9%)

Query: 96  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 155
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 70  TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 125

Query: 156 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR-EVTIPPKYRELLAKKEG 214
           +             +   +++ T  ++    +S    EL K+ +V    K R    KK+ 
Sbjct: 126 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR---TKKKP 171

Query: 215 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 274
              PP       G D+       DF   +P  +  +  K  ++  +        R + PP
Sbjct: 172 TPKPPVVDEAGSGLDNG------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 225

Query: 275 QEKKRKVEKDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 333
                K    T++ +  +E    +   +Q   +      KE   +  + + +EK    D 
Sbjct: 226 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDL 280

Query: 334 TIPSEYRLKPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 390
              S+   KP    +     P L  P+E P P +  E      ++   +  K  P+ P E
Sbjct: 281 APTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKE 339

Query: 391 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 450
               +  +AP    E    T+     + P EPA      P       A +  K+ A    
Sbjct: 340 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 399

Query: 451 GKPVMDKVKEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLP 504
            KP     KE A    +E      +E  P          K+  P  PK+      KE  P
Sbjct: 400 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 459

Query: 505 PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS- 561
              ++       E       + +   E A      +   ++ PA TT   AP  P++ S 
Sbjct: 460 TTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 562 QSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 620
            + K+      K       ++P P   K P     KE A    +    +   T P E   
Sbjct: 514 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAP 569

Query: 621 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 680
                      K  T  + +   P   + P      +L   P+T E    T  ++     
Sbjct: 570 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTT 627

Query: 681 SSSKAPKNGGKAKDSAKTTEETSKP 705
             + AP      K+ A TT +   P
Sbjct: 628 PKAAAPNT---PKEPAPTTPKEPAP 649



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 149/757 (19%), Positives = 245/757 (32%), Gaps = 98/757 (12%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPE----KKSQSTKLSVVHEKKSQEGKP 57
           N  +TK +  S+++   H  ++ +    +  +       +K +S+K S  + +  ++ K 
Sbjct: 100 NKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKV 159

Query: 58  KEH----TEPKSLPK----QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK------TKP 103
           K++    T+ K  PK      + +G ++   K     ++  Q ++ ST PK        P
Sbjct: 160 KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 219

Query: 104 QDMISAGGE-SVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMD---AALDD 159
           +  +    + S      ++ +   + KE  +       + K    S K        +  D
Sbjct: 220 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 279

Query: 160 LIDT---LGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGIT 216
           L  T   L  P  T +  TT  GP ++ P   T      K   +  PK       K   T
Sbjct: 280 LAPTSKVLAKP--TPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT 335

Query: 217 GP--PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 274
            P  PA ++    P              +P      T KE +    K  +  T +  AP 
Sbjct: 336 TPKEPAPTTTKSAPT-------------TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT 382

Query: 275 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 334
             K       T  + A         T   EP     + KE      K           E 
Sbjct: 383 TTKSAPT---TPKEPAPTTPKKPAPTTPKEPA--PTTPKEPTPTTPK-----------EP 426

Query: 335 IPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE-KPSKPTEKTE 393
            P+     P T K+  P  P   +KP P +  E      ++   +  KE  P+ P E   
Sbjct: 427 APTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 483

Query: 394 ESKAAAPAPVSE-AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 452
            +  +AP    E A   T         P P T K   P    E  A +  KK A     +
Sbjct: 484 TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPKKPAPTTPKE 542

Query: 453 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE----SKEQLPPMSE 508
           P     KE A    ++      +   P         K+  P  PK+    + E+L P + 
Sbjct: 543 PAPTTPKEPAPTTTKKPAPTTPKEPAP------TTPKETAPTTPKKLTPTTPEKLAPTTP 596

Query: 509 DFLLDALSEDF--SGPQNASSLKFED--AKLAAAISEVVSQTPASTTQAGAPPRDTSQ-- 562
           +       E+   + P+  +    E+       A +    + PA TT     P    +  
Sbjct: 597 EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 656

Query: 563 --SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 620
             + K+      K +     ++P P    P +   KE A    ++      D   P    
Sbjct: 657 PTTPKETAPTTPKGTAPTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 714

Query: 621 LLDDNGQDKPV----KPPTKKSEDSKKPADDQDPIDAL---SGDLDSCPSTTETSQNTAK 673
                   +P     K P   +     P   ++P           +  P+TT+   +T  
Sbjct: 715 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 674 DKCKKAASSSKAPKNGGK-----AKDSAKTTEETSKP 705
           DK         AP    +      K  A TT ET  P
Sbjct: 775 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 811



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 118/561 (21%), Positives = 191/561 (34%), Gaps = 93/561 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHK--KQAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE 59
            T  K  P + +   P  P K      ++   T PE+ + +T  + +    K +    PKE
Sbjct: 579  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 638

Query: 60   H--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 111
               T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++     
Sbjct: 639  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPTTT 697

Query: 112  ESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 167
            +     T     P    G      K   P  P E  P  P G +      +    T   P
Sbjct: 698  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKP 756

Query: 168  EETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 225
               E   TT  GP    SD  + T  +E      T P +      KK   T P       
Sbjct: 757  APKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET----- 808

Query: 226  IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRK 280
              P      +S+  T   PT   K  +  EST  L A+        +P     P  K   
Sbjct: 809  --PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPA 864

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY- 339
              K  M+  A +  +          E DLR+  E   A  K  K E     ++T  S+  
Sbjct: 865  ATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKIT 913

Query: 340  ----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 385
                ++   T +D  P          L P+     K  + +E++++           E+ 
Sbjct: 914  ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEET 963

Query: 386  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DA 433
            +KP ++   SKA  P P           S +              P P  +  T+P+ + 
Sbjct: 964  AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 1023

Query: 434  VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKD 488
               +A+++ +    P    P    V+   K ED    G + ET      P  +  E   D
Sbjct: 1024 TSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPD 1080

Query: 489  KDGKPLLPKESKEQLPPMSED 509
             D  P +P +     P +S++
Sbjct: 1081 MDYLPRVPNQGIIINPMLSDE 1101


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 152/755 (20%), Positives = 245/755 (32%), Gaps = 87/755 (11%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPK--- 58
           +P  T A P++ +   P  PN    K+ ++    E   ++ + +  +++ S +GK K   
Sbjct: 249 SPKITTAKPINPRPSLP--PNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTS 306

Query: 59  -------EHTEPKSL-----------PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 100
                  E T  K L           PK  + T        K  + +  ++P+  ST PK
Sbjct: 307 AKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPA--STTPK 364

Query: 101 TKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLTPAVPVESKPDKPSG-- 149
                 I +     +  A  T  S     K+      KE    TP  P  +   +P+   
Sbjct: 365 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 424

Query: 150 -KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 208
            KS      +    T   P  T  +    T P+   P +        K      PK    
Sbjct: 425 TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 484

Query: 209 LAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 268
            A K+     P + + P  P +     + + +  +P      T K   T   +     T 
Sbjct: 485 TAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 543

Query: 269 RSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 324
            +   P+E      K+    T  + A         T   EP     + KE      K+  
Sbjct: 544 SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPA 601

Query: 325 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRS 379
                E   T P E    P T K   P  PE       EKP P +  EL     E+    
Sbjct: 602 PTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE---- 655

Query: 380 ECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEA 436
                P+ P E    + KAAAP    E    T      + P EPA  T K T P    + 
Sbjct: 656 ---PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KG 711

Query: 437 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
            A +  K+ A     KP   ++     +E      +K     P         K   P  P
Sbjct: 712 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTP 762

Query: 497 KES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 551
           KE      KE  P   +      L E    P   +  K    +LA   ++  + T +   
Sbjct: 763 KEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKP 818

Query: 552 QAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 611
               P      + K+      K         P P  ++       ++    H+      D
Sbjct: 819 APTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----D 874

Query: 612 DTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETS 668
           ++ P           ++ P +P  PT K+  + KP       D  +  DL + P TT  +
Sbjct: 875 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 934

Query: 669 QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 703
               K+       ++++       + ++ TT++T+
Sbjct: 935 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 969



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 124/625 (19%), Positives = 209/625 (33%), Gaps = 60/625 (9%)

Query: 96  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 155
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 166

Query: 156 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR-EVTIPPKYRELLAKKEG 214
           +             +   +++ T  ++    +S    EL K+ +V    K R    KK+ 
Sbjct: 167 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR---TKKKP 212

Query: 215 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 274
              PP       G D+       DF   +P  +  +  K  ++  +        R + PP
Sbjct: 213 TPKPPVVDEAGSGLDNG------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 266

Query: 275 QEKKRKVEKDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 333
                K    T++ +  +E    +   +Q   +      KE   +  + + +EK    D 
Sbjct: 267 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDL 321

Query: 334 TIPSEYRLKPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 390
              S+   KP    +     P L  P+E P P +  E      ++   +  K  P+ P E
Sbjct: 322 APTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKE 380

Query: 391 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 450
               +  +AP    E    T+     + P EPA      P       A +  K+ A    
Sbjct: 381 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 440

Query: 451 GKPVMDKVKEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLP 504
            KP     KE A    +E      +E  P          K+  P  PK+      KE  P
Sbjct: 441 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 500

Query: 505 PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS- 561
              ++       E       + +   E A      +   ++ PA TT   AP  P++ S 
Sbjct: 501 TTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 562 QSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 620
            + K+      K       ++P P   K P     KE A    +    +   T P E   
Sbjct: 555 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAP 610

Query: 621 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 680
                      K  T  + +   P   + P      +L   P+T E    T  ++     
Sbjct: 611 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTT 668

Query: 681 SSSKAPKNGGKAKDSAKTTEETSKP 705
             + AP      K+ A TT +   P
Sbjct: 669 PKAAAPNT---PKEPAPTTPKEPAP 690



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 149/757 (19%), Positives = 245/757 (32%), Gaps = 98/757 (12%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPE----KKSQSTKLSVVHEKKSQEGKP 57
           N  +TK +  S+++   H  ++ +    +  +       +K +S+K S  + +  ++ K 
Sbjct: 141 NKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKV 200

Query: 58  KEH----TEPKSLPK----QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK------TKP 103
           K++    T+ K  PK      + +G ++   K     ++  Q ++ ST PK        P
Sbjct: 201 KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 260

Query: 104 QDMISAGGE-SVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMD---AALDD 159
           +  +    + S      ++ +   + KE  +       + K    S K        +  D
Sbjct: 261 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 320

Query: 160 LIDT---LGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGIT 216
           L  T   L  P  T +  TT  GP ++ P   T      K   +  PK       K   T
Sbjct: 321 LAPTSKVLAKP--TPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT 376

Query: 217 GP--PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 274
            P  PA ++    P              +P      T KE +    K  +  T +  AP 
Sbjct: 377 TPKEPAPTTTKSAPT-------------TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPT 423

Query: 275 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 334
             K       T  + A         T   EP     + KE      K           E 
Sbjct: 424 TTKSAPT---TPKEPAPTTPKKPAPTTPKEPA--PTTPKEPTPTTPK-----------EP 467

Query: 335 IPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE-KPSKPTEKTE 393
            P+     P T K+  P  P   +KP P +  E      ++   +  KE  P+ P E   
Sbjct: 468 APTTKEPAPTTPKEPAPTAP---KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 524

Query: 394 ESKAAAPAPVSE-AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 452
            +  +AP    E A   T         P P T K   P    E  A +  KK A     +
Sbjct: 525 TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPKKPAPTTPKE 583

Query: 453 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE----SKEQLPPMSE 508
           P     KE A    ++      +   P         K+  P  PK+    + E+L P + 
Sbjct: 584 PAPTTPKEPAPTTTKKPAPTTPKEPAP------TTPKETAPTTPKKLTPTTPEKLAPTTP 637

Query: 509 DFLLDALSEDF--SGPQNASSLKFED--AKLAAAISEVVSQTPASTTQAGAPPRDTSQ-- 562
           +       E+   + P+  +    E+       A +    + PA TT     P    +  
Sbjct: 638 EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 697

Query: 563 --SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 620
             + K+      K +     ++P P    P +   KE A    ++      D   P    
Sbjct: 698 PTTPKETAPTTPKGTAPTTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 755

Query: 621 LLDDNGQDKPV----KPPTKKSEDSKKPADDQDPIDAL---SGDLDSCPSTTETSQNTAK 673
                   +P     K P   +     P   ++P           +  P+TT+   +T  
Sbjct: 756 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 674 DKCKKAASSSKAPKNGGK-----AKDSAKTTEETSKP 705
           DK         AP    +      K  A TT ET  P
Sbjct: 816 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPP 852



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 118/561 (21%), Positives = 191/561 (34%), Gaps = 93/561 (16%)

Query: 4    TETKAIPVSQQMEGPHLPNKKKHK--KQAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE 59
            T  K  P + +   P  P K      ++   T PE+ + +T  + +    K +    PKE
Sbjct: 620  TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 679

Query: 60   H--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 111
               T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++     
Sbjct: 680  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPTTT 738

Query: 112  ESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 167
            +     T     P    G      K   P  P E  P  P G +      +    T   P
Sbjct: 739  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKP 797

Query: 168  EETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 225
               E   TT  GP    SD  + T  +E      T P +      KK   T P       
Sbjct: 798  APKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET----- 849

Query: 226  IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRK 280
              P      +S+  T   PT   K  +  EST  L A+        +P     P  K   
Sbjct: 850  --PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPA 905

Query: 281  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY- 339
              K  M+  A +  +          E DLR+  E   A  K  K E     ++T  S+  
Sbjct: 906  ATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKIT 954

Query: 340  ----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 385
                ++   T +D  P          L P+     K  + +E++++           E+ 
Sbjct: 955  ATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEET 1004

Query: 386  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DA 433
            +KP ++   SKA  P P           S +              P P  +  T+P+ + 
Sbjct: 1005 AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 1064

Query: 434  VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKD 488
               +A+++ +    P    P    V+   K ED    G + ET      P  +  E   D
Sbjct: 1065 TSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPD 1121

Query: 489  KDGKPLLPKESKEQLPPMSED 509
             D  P +P +     P +S++
Sbjct: 1122 MDYLPRVPNQGIIINPMLSDE 1142


>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
           sapiens]
          Length = 929

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 111/521 (21%), Positives = 186/521 (35%), Gaps = 69/521 (13%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHT 61
           +P      PV++       P + K      KT+     Q TK     +  +  G P    
Sbjct: 243 SPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR-- 300

Query: 62  EPKSLPKQASDTG---SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 118
            PK++ K+    G   S  +     V+    Q P    T  +T    +     +    + 
Sbjct: 301 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK 360

Query: 119 AI-----SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE-- 171
            I     +GK   + + KK++     +E+  D    ++  +   D    + G   E +  
Sbjct: 361 QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF 420

Query: 172 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDA 231
                 +GPE + P +ST      K   T  P           ++G  + S      D +
Sbjct: 421 TSPKRISGPECTTPKASTSANNFTKSGSTPLP-----------LSGGTSSSDNSWTMDAS 469

Query: 232 IDALSSDFTCGSPTAAGKKTEKEESTEVL--------KAQSAGTVRSAAPPQEKKRKVEK 283
           ID +      G+P+          S  V         K     T   ++   +KK K E 
Sbjct: 470 IDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKEL 529

Query: 284 DTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE----------DDE 333
            T   +  +        R+ E + +    KE D+ K KE+  E   E          ++E
Sbjct: 530 KTKMKKKEKQRD-----REREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEE 584

Query: 334 TIPSEYRLKPATDKDGKPLLPEP---EEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 390
             P ++++K   D D K  L +    +EK K + + +  ++  +D D+ E KEK     +
Sbjct: 585 ADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE-KEKVK---D 640

Query: 391 KTEESKAAAPAP---VSEAVCRTSMCSIQSAPPEPATLKGTVP---------DDAVEALA 438
           K  E K  APAP   +        + S  +A   PA L   +P          + V+   
Sbjct: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700

Query: 439 DSLGKKEA----DPEDGKPVMDKVKEKAKEEDREKLGEKEE 475
               KKE     + E  K   ++ KEK + E REK  EK +
Sbjct: 701 KKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 103/528 (19%), Positives = 180/528 (34%), Gaps = 100/528 (18%)

Query: 172 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDA 231
           +++T    P    PM +   +   +     P + +    K +  T  P   +K   P  A
Sbjct: 234 QDSTDLAPPSPEPPMLAPVAKS--QMPTAKPLETKSFTPKTKTKTSSPGQKTK--SPKTA 289

Query: 232 IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV-----EKDTM 286
                S    GSP  + K   KE+       +S G  RS +P   K  KV     +    
Sbjct: 290 ----QSPAMVGSPIRSPKTVSKEK-------KSPG--RSKSPKSPKSPKVTTHIPQTPVR 336

Query: 287 SDQALEALSASLGTRQAEPELDLRSIKEVDEAKA--KEEKLEKCGEDDETI--------- 335
            +      SA+L  + ++  + ++ I+   +A     E + +K    D+TI         
Sbjct: 337 PETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIA 396

Query: 336 -------PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 388
                  P  +     ++ +G  +   P+    P   +      + +F +S     P   
Sbjct: 397 RACAEREPDPFEFSSGSESEGD-IFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSG 455

Query: 389 TEKTEESKAAAPAPVSEAVCRTSM-------------CSIQSAPPEPATL------KGTV 429
              + ++     A + E V +  +              S   +PP P  L      K  +
Sbjct: 456 GTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515

Query: 430 PDDAV------EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---------- 473
           P          + L   + KKE    D +   DK K+K+KE+D+ K  EK          
Sbjct: 516 PSSVEVKKKLKKELKTKMKKKEKQ-RDREREKDKNKDKSKEKDKVKEKEKDKETGRETKY 574

Query: 474 --------EETIPPDYRLEEVKDKDGKPLLP----KESKEQLPPMSEDFLLDALSEDFSG 521
                   EE  P  ++++E +D D K  L     ++ KE+     +D       +D   
Sbjct: 575 PWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE 634

Query: 522 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSL--- 578
            +       ED   A A   V+   P         P   S+    L   L  L + L   
Sbjct: 635 KEKVKDKGREDKMKAPAPPLVL--PPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEE 692

Query: 579 ------GQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 620
                  +++ D  E K  ++K KEK + E   +  ER+     + +H
Sbjct: 693 KEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH 740



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 50/234 (21%), Positives = 79/234 (33%), Gaps = 14/234 (5%)

Query: 2   NPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHT 61
           +P     +P       P LP K   +K+ VK + +KK +        EKK ++ K KE  
Sbjct: 667 SPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKK-------EKKKKKEKEKEKK 719

Query: 62  EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 121
           E K   K+  +    +   +K      + +P   +  P      +    G+    I+ + 
Sbjct: 720 E-KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVV 778

Query: 122 GKPGDK--KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 179
             P  K    + +  TP  P  +    P   S     L  L     GP          +G
Sbjct: 779 PAPEAKPAPSQNRPKTPP-PAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASG 837

Query: 180 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAID 233
                P+ S   E +      I  ++   +    G    P D S  IG DD  D
Sbjct: 838 ASAKAPVRSVVTETVS--TYVIRDEWGNQIWICPG-CNKPDDGSPMIGCDDCDD 888


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 107/476 (22%), Positives = 180/476 (37%), Gaps = 55/476 (11%)

Query: 270 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 329
           S+APP   +   E       A  + + S  T  ++   D  S     +++  E       
Sbjct: 447 SSAPPSAPQSLPEPVA---SAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAP 503

Query: 330 EDDETIPSEYRLKPATDKDGKPLLPEPE-----EKPKPRSESELIDELSEDFDRSECKEK 384
           E +    ++++L     K  +P  P PE     E P+   ES+   + +   + SE K+ 
Sbjct: 504 EPEPPTTNKWQLDNWLTKVSQPAAP-PEGPRSTEPPRRHPESKGSSDSATSQEHSESKDP 562

Query: 385 PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADS---- 440
           P K + K   +   AP P  +  C+ S    Q  PP+  T+    P   V+A A +    
Sbjct: 563 PPKSSSKAPRAPPEAPHP-GKRSCQKS--PAQQEPPQRQTVGTKQPKKPVKASARAGSRT 619

Query: 441 --LGKKEAD--PEDGKPVMDKVKEKAKEEDREKL---GEKEETIPPDYRLEEVKDKDGKP 493
              G++E    P   +    K K K K + R +     E +  +PP    E+ K K   P
Sbjct: 620 SLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPS--SEKKKHKSSLP 677

Query: 494 LL------PKESKEQLPPMS-EDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQ- 545
                   P+ +K+ +   + E F L  L+E    P + S  +    + A  + E   + 
Sbjct: 678 APSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKD 737

Query: 546 ---TPASTTQAGAPPRDT----SQSDKDLDDALDKLSD--SLGQRQPDPDENKPMEDK-- 594
               P   T+  +P RDT    S   K   D L ++      G RQ   ++ +P   K  
Sbjct: 738 RLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKH 797

Query: 595 VKEKAKAEHRDKLGERDDTIPPEYRHLLDDN--GQDKPVKPPTKKSEDSKKPADDQDP-- 650
             EK  ++   KL ++      E     D+     +K +K  +  S  S K +    P  
Sbjct: 798 SSEKRSSDSSSKLAKKR---KGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSR 854

Query: 651 --IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 704
               +   ++   P  + +SQ  AK   K+  S  +A   G     SA +T+   K
Sbjct: 855 PSSQSSKKEMLPPPPVSSSSQKPAKPALKR--SRREADTCGQDPPKSASSTKSNHK 908



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 98/484 (20%), Positives = 176/484 (36%), Gaps = 56/484 (11%)

Query: 18  PHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND 77
           P  P +     +  +  PE K  S   +     +S++  PK  ++    P +A   G   
Sbjct: 525 PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPG--- 581

Query: 78  AHNKKAVSRS-AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 136
              K++  +S A+Q+P ++ T    +P+  + A   +    T++ G     ++E   L  
Sbjct: 582 ---KRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARA-GSRTSLQG-----EREPGLLPY 632

Query: 137 AVPVESKPDKPSGKS-GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 195
               ++  DKP  K+ G   A          P  +E++    + P  S  +S     +  
Sbjct: 633 GSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN 692

Query: 196 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 255
             + T  P++  L+   E   GPP   S            S    C       + + K+ 
Sbjct: 693 VEDRT--PEHFALVPLTES-QGPPHSGSG-----------SRTSGCRQAVVVQEDSRKDR 738

Query: 256 STEVLK-AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKE 314
               L+  +    +R   PPQ    K+  D +S           G+RQ       R  ++
Sbjct: 739 LPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLS---RIPQPPGKGSRQ-------RKAED 788

Query: 315 VDEAKAKEEKLEKCGEDDETIPSEYRLKPA-TDKDGKPLLPEPEEKPKPRSESELIDELS 373
                 K+   EK   D  +  ++ R   A  D D K +  E E K +  S S    E S
Sbjct: 789 KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESS 848

Query: 374 EDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDA 433
                   K KPS+P+ ++ + +   P PVS +  + +  +++ +  E  T     P  A
Sbjct: 849 --------KTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA 900

Query: 434 VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 493
                     K    +   P   +V+ K      E  G   +T  P + +  + + + KP
Sbjct: 901 SST-------KSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANP-FPVPSLPNGNSKP 952

Query: 494 LLPK 497
             P+
Sbjct: 953 GKPQ 956



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 46/202 (22%), Positives = 69/202 (34%), Gaps = 41/202 (20%)

Query: 523 QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----------------RDTSQSDKD 566
           Q  SS+  +D +L+ +      QTP     + APP                   S+S  D
Sbjct: 417 QGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSD 476

Query: 567 LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 626
            D + D  S+S      D +EN+P+E    E                 PP       DN 
Sbjct: 477 SDSSSDSESES---SSSDSEENEPLETPAPEPE---------------PPTTNKWQLDNW 518

Query: 627 QDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAP 686
             K  +P              + P    S D       + TSQ  ++ K     SSSKAP
Sbjct: 519 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSD-------SATSQEHSESKDPPPKSSSKAP 571

Query: 687 KNGGKAKDSAKTTEETSKPKDD 708
           +   +A    K + + S  + +
Sbjct: 572 RAPPEAPHPGKRSCQKSPAQQE 593



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 12/132 (9%)

Query: 31  VKTEPEKKSQSTKLSVVHEK--KSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSA 88
           ++ E E KSQS+  S  H++  K++  +P   +  K +      + S+    K A+ RS 
Sbjct: 827 IRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSR 886

Query: 89  EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT---------PAVP 139
            +  +     PK+      +    S+     + GK      E K  +         P++P
Sbjct: 887 READTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLP 946

Query: 140 -VESKPDKPSGK 150
              SKP KP  K
Sbjct: 947 NGNSKPGKPQVK 958



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 43/198 (21%), Positives = 81/198 (40%), Gaps = 27/198 (13%)

Query: 5    ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK-KSQSTKLSV-----VHEKKSQEGKP- 57
            + K I + ++++     +   HK+ + KT+P +  SQS+K  +     V     +  KP 
Sbjct: 823  DNKKIRLEKEIKSQSSSSSSSHKESS-KTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPA 881

Query: 58   ------KEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 111
                  +  T  +  PK AS T SN   +     R  E + S  S+E K    D  +A  
Sbjct: 882  LKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGD--TANP 939

Query: 112  ESVAGITAISGKPG------DKKKEKKSLTPAVPVESKPDKPSGKSG-----MDAALDDL 160
              V  +   + KPG      DK++    +  A  ++ K +  + + G     ++A L  +
Sbjct: 940  FPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFI 999

Query: 161  IDTLGGPEETEEENTTYT 178
               +    E++   + Y+
Sbjct: 1000 ECGIATESESQSSKSAYS 1017


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 142/714 (19%), Positives = 257/714 (35%), Gaps = 96/714 (13%)

Query: 3     PTETKAIPVSQQMEGP--HLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
             P E K  PV +++E P   +P K++     V    E++    +  V  E+   E +    
Sbjct: 10069 PEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLP 10128

Query: 61    TEPKSLPKQASDTGSNDA--HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 118
              E + LP++       +     ++ V    E  P E+   P+ +    +       A + 
Sbjct: 10129 EEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVP 10188

Query: 119   AISGKPGDKKK--EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 176
              I  K  +KK    KK   P   V   P K   K  +    ++++     P E  EE   
Sbjct: 10189 EIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVL-----PVEVTEEPEE 10243

Query: 177   YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 236
                 E   P     IEE+   E   PP+  E++  K+ +   P    K +          
Sbjct: 10244 EPISEEEIPEEPPSIEEV---EEVAPPRVPEVI--KKAVPEAPTPVPKKVE--------- 10289

Query: 237   SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 296
                    P    KK  +E+    ++ + A     A  P+  K+  EK  +  +  EA+  
Sbjct: 10290 -----APPAKVSKKIPEEKVPVPVQKKEAPP---AKVPEVPKKVPEKKVLVPKK-EAVPP 10340

Query: 297   SLGTRQAEPELDLRS-----IKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 351
             + G    E ++ +       +KE  E +  E ++E+  E++E    E   +     + + 
Sbjct: 10341 AKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEE 10400

Query: 352   LLPEPEEKPKPRSESELIDELSEDFDRSECK--EKPSKPTEKTEESKAAAPA--PVSEAV 407
              +   + + +     E +  + E F+  E +  EKP  P +  E S+   P   P ++ V
Sbjct: 10401 FIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVV 10460

Query: 408   CRTSMCSIQSAPPEPATL--KGTVPDDA---VEALADSLGKKEADPEDGKPVMDKVKEKA 462
              R    +     P+   +  K  VP++       + + L  KE  PE   PV    K +A
Sbjct: 10461 PRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEA 10520

Query: 463   K-----EEDREKLGEKEETIPPDYRLE----EVKDKDGKPLLPKESKEQLPPMSEDFLLD 513
                   E  +E + EK+  +PP  + E    +V +     +  K+  E +PP  E     
Sbjct: 10521 PPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPES---- 10576

Query: 514   ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDK 573
                                 ++  A  EVV +         APP+    +   + +A  +
Sbjct: 10577 -----------------PPPEVPEAPKEVVPEKKVPA----APPKKPEVTPVKVPEAPKE 10615

Query: 574   LSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP 633
             +        P P + +    KV E  K    +K  +  + IPP            KP  P
Sbjct: 10616 VVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEK--KVPEAIPP------------KPESP 10661

Query: 634   PTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPK 687
             P +  E+ ++ A ++ P + +     + P            + K  A  +K P+
Sbjct: 10662 PPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPE 10715



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 143/752 (19%), Positives = 273/752 (36%), Gaps = 120/752 (15%)

Query: 32   KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGS---NDAHNKKAVSRSA 88
            K  P K+ + TK +V  + K    KPKE T  + + K+     +     A     VS  A
Sbjct: 8975 KKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKA 9034

Query: 89   EQQPSEKSTEPKT--KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV-----PVE 141
            E+      T  K   K ++ +    ++V     +  +  ++  ++  + P       P  
Sbjct: 9035 EEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYY 9094

Query: 142  SKPDKPSGKSGMDAALD-------------DLIDTLGGPEETEEE-NTTYTGPEVSDPMS 187
             +PD+   +  ++A  +             +  +   G +E EEE    Y   EV     
Sbjct: 9095 EEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQK 9154

Query: 188  STYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 247
              Y E     E  +P K  E  A       PP    KP+     I+ +            
Sbjct: 9155 EVYEES---HERKVPAKVPEKKAPP-----PPKVIKKPV-----IEKI------------ 9189

Query: 248  GKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPEL 307
             +KT +    E ++      V     PQ+  R      + ++ +E    ++ T++    +
Sbjct: 9190 -EKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRT----PVQEEVIEVKVPAVHTKK----M 9240

Query: 308  DLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDK--DGKPLLPEPEEKPKPRSE 365
             +   K    +  +EE      E  + I +E ++  A  K  +  P +PE  EKP P   
Sbjct: 9241 VISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEV 9300

Query: 366  SELIDELSEDFDRSECKEKPSKPTEKTEE------SKAAAPA--------PVSEAVCRTS 411
            + +      +    +  E P KP  + ++       + AAP         PV E      
Sbjct: 9301 APVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP 9360

Query: 412  MCSIQSAPPE--PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 469
            +   + APP   P   KG V ++ +  +     ++E+ P    P + ++ +K   E+R+ 
Sbjct: 9361 VAKKKEAPPAKVPEVQKGVVTEEKITIVTQ---REESPP----PAVPEIPKKKVPEERKP 9413

Query: 470  LGEKEETIPPDYRLEEVKDK---DGKPLLPKESKEQLPPMSEDFLLDALSED-------- 518
            +  KEE +PP  ++  +  K   + K  +P    ++ PP   +     + E+        
Sbjct: 9414 VPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEK 9473

Query: 519  --FSGPQNASSLKFE----------DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKD 566
              F+ PQ     + E          + +   +IS    +      +A     +  +  ++
Sbjct: 9474 LSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEE 9533

Query: 567  --LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD----KLGERDDTIPPEYRH 620
              +++ L  +S  +     +  E +  +  +K K  A+  +    K+ E    I PE + 
Sbjct: 9534 YVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKK- 9592

Query: 621  LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPS--TTETSQNTAKDKCKK 678
             +      K   PP K  E+ KKP  ++     +    +  P+  T    Q T ++K   
Sbjct: 9593 -VPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLV 9651

Query: 679  AASSSKAPKNGGKAKDSAKTTEETS----KPK 706
            A +  +AP      ++  +   E      KPK
Sbjct: 9652 AVTKKEAPPKARVPEEPKRAVPEEKVLKLKPK 9683



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 159/707 (22%), Positives = 257/707 (36%), Gaps = 132/707 (18%)

Query: 3     PTETKAIPVSQQM--EGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
             P E + +P  ++   E   LP  K  K       PE K + T+  VV  KK +    K  
Sbjct: 10155 PPEEEYVPEEEEFVPEEEVLPEVKP-KVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVP 10213

Query: 61    TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKP--QDMISAGGESVAGIT 118
               PK + ++           +  + +  E  P E + EP+ +P  ++ I     S+  + 
Sbjct: 10214 EVPKKVEEK-----------RIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVE 10262

Query: 119   AISGKPGDKKKEKKSLTPA-VPVESKPDKPSGKSGMDAALDDLIDTLGGPEET------E 171
              ++  P   +  KK++  A  PV  K + P  K                PEE       +
Sbjct: 10263 EVA-PPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKI-----------PEEKVPVPVQK 10310

Query: 172   EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDA 231
             +E      PEV   +    +  + K+E   P K R +L +K  +        K     + 
Sbjct: 10311 KEAPPAKVPEVPKKVPEKKVL-VPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEV 10369

Query: 232   IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT-------VRSAAPPQEKKRKVEKD 284
             ++A   +             E+EE  EV +    G        ++      E++ +VEK 
Sbjct: 10370 VEAEVEEIP-----------EEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKV 10418

Query: 285   TMSDQALEALSASLGTRQAEP----ELDLRSI-----------KEVDEAKAKEEKLEKCG 329
                 +  EA    +  +   P    E+  + I           ++   AK  E   +   
Sbjct: 10419 HRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVV 10478

Query: 330   EDDETIPSEYRLKPATDKDGKP---LLPE------PEEKPK------PRSESELIDELSE 374
             E+   +P E R+ P    +  P   ++PE      P +KP+      P +  E++ E   
Sbjct: 10479 EEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKV 10538

Query: 375   DFDRSECKEKPSKPTEKTEESKAAAPAP-VSEAVCRTSMCSIQSAPPEPATLKGTVPDDA 433
                  +  E P  PT+  E  KAA P   V EA+           PP+P +    VP+  
Sbjct: 10539 PVPPPKKPEVP--PTKVPEVPKAAVPEKKVPEAI-----------PPKPESPPPEVPEAP 10585

Query: 434   VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 493
              E + +   KK       KP +  VK    E  +E + EK+  +PP  + E    K   P
Sbjct: 10586 KEVVPE---KKVPAAPPKKPEVTPVK--VPEAPKEVVPEKKVPVPPPKKPEVPPTK--VP 10638

Query: 494   LLPK----ESK--EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT- 546
              +PK    E K  E +PP  E        E F  P        E+  L    +EVV +  
Sbjct: 10639 EVPKVAVPEKKVPEAIPPKPES----PPPEVFEEP--------EEVALEEPPAEVVEEPE 10686

Query: 547   PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK---EKAKAEH 603
             PA+  Q   PP+     +K     + K  +    + P+  +    E KV     K     
Sbjct: 10687 PAAPPQVTVPPKKPVP-EKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAP 10745

Query: 604   RDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDP 650
               K+ E    + PE +  +      KP  PP K  E  KKP  ++ P
Sbjct: 10746 PAKVPEVPKEVVPEKKVAVPK----KPEVPPAKVPEVPKKPVLEEKP 10788



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 129/530 (24%), Positives = 188/530 (35%), Gaps = 93/530 (17%)

Query: 20    LPNKKKHKKQAVKTE-PEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDA 78
             +P KK     A K E P  K       VV EKK     PK+   P++ P +  +      
Sbjct: 10701 VPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKK---PEAPPAKVPEVPKEVV 10757

Query: 79    HNKK-AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA 137
               KK AV +  E  P++    PK                      KP  ++K      PA
Sbjct: 10758 PEKKVAVPKKPEVPPAKVPEVPK----------------------KPVLEEK------PA 10789

Query: 138   VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 197
             VPV  + + P              +    PEE   E      PE   P+     EE    
Sbjct: 10790 VPVPERAESPPP------------EVYEEPEEIAPEEEI--APEEEKPVPVAEEEEPEVP 10835

Query: 198   EVTIPPKYRELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 255
                +P + ++++ +K+   I  P A   K   P+  I+          P  A  K + +E
Sbjct: 10836 PPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKE 10895

Query: 256   STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA-LEALSASLGTRQAEPELDLRSIKE 314
                 LKA              KK+  EK  + ++  L  L    G ++    L  R  + 
Sbjct: 10896 KIFQLKAIP------------KKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEP 10943

Query: 315   VDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSE 374
              +E   K   L K  E++E      +L    +K  KP +PEP   PKP  E E+      
Sbjct: 10944 KEEVVLKSV-LRKRPEEEEPKVEPKKL----EKVKKPAVPEPPP-PKPVEEVEVPTVTKR 10997

Query: 375   DFDRSECKEKPSKPTEKTEESKAAAPAPVSE------AVCRTSMCSIQSAPPEPATLKGT 428
             +        K  +PT K  E K A P P  E      A  +T         P P     T
Sbjct: 10998 E-------RKIPEPT-KVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVT 11049

Query: 429   VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL-----GEK-EETIPPDYR 482
             VP    +A A +  ++ A P+     + K      E +R KL     GEK  +  P  Y+
Sbjct: 11050 VPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQ 11109

Query: 483   LEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFED 532
             L+ V  K       KE K+ +   SE     A+ E    P  A +   +D
Sbjct: 11110 LKAVPLK-----FVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKD 11154



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 144/723 (19%), Positives = 247/723 (34%), Gaps = 116/723 (16%)

Query: 3     PTETKAIPVSQQMEGP-----HLPNKKKHKKQAV-----KTEPEKKSQSTKLSVVHEKKS 52
             P E K +PV ++ E P      +P K + K   +     K  P K  +  K  V  EK  
Sbjct: 9959  PEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVP 10018

Query: 53    QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE-PKTKPQDMISAGG 111
                  K    P  +P+            KK V       P+ K  E P  K  ++     
Sbjct: 10019 VPVPKKVEAPPAKVPEVP----------KKPVPEKKVPVPAPKKVEAPPAKVPEVPKK-- 10066

Query: 112   ESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE 171
                  +     KP    K+ ++  P VP + +P        +  AL    + L   E   
Sbjct: 10067 -----LIPEEKKPTPVPKKVEAPPPKVPKKREPVP------VPVALPQEEEVLFEEEIVP 10115

Query: 172   EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-----I 226
             EE      PE  + +     EE+   E  + P+  E+  ++E +  PP +   P     +
Sbjct: 10116 EEEVL---PEEEEVLPEE--EEVLPEEEEVLPEEEEIPPEEEEV--PPEEEYVPEEEEFV 10168

Query: 227   GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 286
               ++ +  +       +P    KK   E+   + K + A     A  P+  K+  EK  +
Sbjct: 10169 PEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPP---AKVPEVPKKVEEKRII 10225

Query: 287   SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 346
               +  E L   +     EPE +  S +E+ E     E++E      E  P      P   
Sbjct: 10226 LPKEEEVLPVEV---TEEPEEEPISEEEIPEEPPSIEEVE------EVAPPRV---PEVI 10273

Query: 347   KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE------KTEESKAAAP 400
             K   P  P P  K      +++  ++ E+      ++K + P +      K  E K   P
Sbjct: 10274 KKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVP 10333

Query: 401   AP--VSEAVCRTSMCS-IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPE-------- 449
                 V  A  RT +   +  A  +   +K  +  + VEA  + + ++E   E        
Sbjct: 10334 KKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEG 10393

Query: 450   DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 509
             +   V + +K +    + E   EK   +   +  EEV+  + KP  P +     P +SE 
Sbjct: 10394 EFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFE-KPKAPPKG----PEISEK 10448

Query: 510   FLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS-----QTPASTTQAGAPPRDTSQSD 564
              +          P+     K  +      + E V      + P +      PP++     
Sbjct: 10449 IIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEK 10508

Query: 565   KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDD 624
             K                 P P   KP  +    K     ++ + E+   +PP        
Sbjct: 10509 K----------------VPVPPAKKP--EAPPPKVPEAPKEVVPEKKVPVPPP------- 10543

Query: 625   NGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSK 684
                 KP  PPTK  E  K    ++   +A+    +S P     +      + K  A+  K
Sbjct: 10544 ---KKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPK 10600

Query: 685   APK 687
              P+
Sbjct: 10601 KPE 10603



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 111/479 (23%), Positives = 174/479 (36%), Gaps = 104/479 (21%)

Query: 10    PVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGK----PK----EHT 61
             PV ++ +   +P KK+     V   P+K  +   + +  ++K    K    PK    E  
Sbjct: 9957  PVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEK 10016

Query: 62    EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV-AGITAI 120
              P  +PK+       +A   K      +  P +K   P  K  +   A    V   +   
Sbjct: 10017 VPVPVPKKV------EAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPE 10070

Query: 121   SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
               KP    K+ ++  P VP + +P        +  AL    + L   E   EE      P
Sbjct: 10071 EKKPTPVPKKVEAPPPKVPKKREP------VPVPVALPQEEEVLFEEEIVPEEEVL---P 10121

Query: 181   EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
             E          EE+   E  + P+  E+L ++E I  PP +   P  P++       +F 
Sbjct: 10122 EE---------EEVLPEEEEVLPEEEEVLPEEEEI--PPEEEEVP--PEEEYVPEEEEFV 10168

Query: 241   CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
                              EVL          A  P+ KK+  EK  +  +  EA  A +  
Sbjct: 10169 --------------PEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKV-- 10212

Query: 301   RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
                 PE+           K  EEK     +++E +P E             +  EPEE  
Sbjct: 10213 ----PEV----------PKKVEEKRIILPKEEEVLPVE-------------VTEEPEE-- 10243

Query: 361   KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
             +P SE E+ +E     +  E    P +  E  +++   AP PV + V          APP
Sbjct: 10244 EPISEEEIPEEPPSIEEVEEV--APPRVPEVIKKAVPEAPTPVPKKV---------EAPP 10292

Query: 421   EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 479
                + K  +P++ V      + KKEA P     V  KV EK      + L  K+E +PP
Sbjct: 10293 AKVSKK--IPEEKVPV---PVQKKEAPPAKVPEVPKKVPEK------KVLVPKKEAVPP 10340



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 133/662 (20%), Positives = 243/662 (36%), Gaps = 138/662 (20%)

Query: 7     KAIPVSQQMEGPHLPNKKKHKKQAV--KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 64
             K IPV    E P +P K K     V  K  PE+K     + V   KK +   PK   EPK
Sbjct: 9791  KPIPVKPVPEEP-VPTKPKAPPAKVLKKAVPEEK-----VPVPIPKKLKPPPPKVPEEPK 9844

Query: 65    SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 124
              + ++           + ++++  ++Q +E + +   KP+ +++   E V         P
Sbjct: 9845  KVFEEKI---------RISITKREKEQVTEPAAKVPMKPKRVVAE--EKV---------P 9884

Query: 125   GDKKKEKKSL-TPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS 183
               +K+    +  P VP E +P++ + +  +   +++ +  +   EE   E   +   E  
Sbjct: 9885  VPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYL--VEEEEEYIHEEEEFITEEEV 9942

Query: 184   DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSK-PIGPDDAIDALSSDFTCG 242
              P+    + E+ ++ V    K   +  KKE    PPA   + P  P++ +  L       
Sbjct: 9943  VPVIPVKVPEVPRKPVPEEKKPVPVPKKKEA---PPAKVPEVPKKPEEKVPVLIP----- 9994

Query: 243   SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ 302
                    K EK    +V +           P    K+           +EA  A +    
Sbjct: 9995  -------KKEKPPPAKVPEVPKKPVPEEKVPVPVPKK-----------VEAPPAKV---- 10032

Query: 303   AEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKP 362
               PE+  + + E        +K+E        +P             K L+PE E+KP P
Sbjct: 10033 --PEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVP-------------KKLIPE-EKKPTP 10076

Query: 363   RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 422
                                 +K   P  K  + +   P PV+       +   +  P E 
Sbjct: 10077 ------------------VPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEE 10118

Query: 423   ATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEED----REKLGEKEETIP 478
                   +P++  E L +   ++E  PE+ + + ++ +   +EE+     E + E+EE +P
Sbjct: 10119 V-----LPEEE-EVLPE---EEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVP 10169

Query: 479   PDYRLEEVKDK---------------DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 523
              +  L EVK K               + K ++PK  KE+ PP     +   + E      
Sbjct: 10170 EEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPK--KEEAPPAKVPEVPKKVEE------ 10221

Query: 524   NASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP 583
                 L  E+  L   ++E   + P S  +    P    + ++     + ++      ++ 
Sbjct: 10222 KRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVI-----KKA 10276

Query: 584   DPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKK 643
              P+   P+  KV E   A+   K+ E    +P + +        + P K P KK    KK
Sbjct: 10277 VPEAPTPVPKKV-EAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKK 10335

Query: 644   PA 645
              A
Sbjct: 10336 EA 10337



 Score = 37.0 bits (84), Expect = 0.063
 Identities = 74/388 (19%), Positives = 135/388 (34%), Gaps = 48/388 (12%)

Query: 352  LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTS 411
            LLP PEEK  P    E+  +  +  D  +   KP + T + E  K   P           
Sbjct: 8968 LLPTPEEKKPPPKRIEVTKKAVKK-DAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPE 9026

Query: 412  MCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLG 471
            +  + S   E   +  T   +  +       KK+A  ++ +  ++       EE  ++L 
Sbjct: 9027 IIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESF-----EEPYDELE 9081

Query: 472  EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDF----LLDALSEDFSGPQNASS 527
             +  T P +    E  D+D + +  +  KE      EDF          E +   +    
Sbjct: 9082 VEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWE 9141

Query: 528  LKFEDAKLAAAISEVVSQT-----PASTTQAGAPP-------------RDTSQSDKDLDD 569
              +++ ++     EV  ++     PA   +  APP               TS+  ++   
Sbjct: 9142 EAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKV 9201

Query: 570  ALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKL--------------GERDDTI 614
             + K+ +   +  P      P++++V E K  A H  K+               E   T+
Sbjct: 9202 QVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTV 9261

Query: 615  PPEYRHLLDDN----GQDKPVKPPTKKSEDSKKPADDQ-DPIDALSGDLDSCPSTTETSQ 669
            P   + ++ +        K V+PP K  E  +KPA ++  P+          P   E  +
Sbjct: 9262 PEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPK 9321

Query: 670  NTAKDKCKKAASSSKAPKNGGKAKDSAK 697
                ++ K      K P    K  +  K
Sbjct: 9322 KPVPEEKKPVPVPKKEPAAPPKVPEVPK 9349


>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
          Length = 674

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 112/563 (19%), Positives = 204/563 (36%), Gaps = 89/563 (15%)

Query: 16  EGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGS 75
           E P LP   K  + A      K        +  E       P+  TE +   +   D+  
Sbjct: 21  ERPELPGLHKLYENAEPDTMAKADSKLPAEIYQE-------PQPETEEEDFKEGEPDSAK 73

Query: 76  NDAHNKKAVSRSAEQQPSEKSTEPKTKP---QDMISAGGESVAGITAISGKPGDKKKEKK 132
           N        S+    + S++    +T+P   Q++ S     +         P D+  ++ 
Sbjct: 74  NVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKES 133

Query: 133 SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 192
            L P  P E+KP+        D  L+  ++T   P    E  +  +G  V +       E
Sbjct: 134 DLEP--PEEAKPNVTE-----DVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEE 186

Query: 193 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 252
           E    E  +P +   +  ++ G+   P + +K   P + +     +     P     K  
Sbjct: 187 ET---EPGVPEESLRVQHEETGLE--PPEQTKQDFPSEKLGESLEETDLQPP-----KMT 236

Query: 253 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 312
           K E+ E  + +S    R+  P Q +   +EK+         L          PE     +
Sbjct: 237 KPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLE--------PPEETQPEV 288

Query: 313 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPE-----PEEKPKPRSESE 367
            E  + KA EEK  +  E  +    +++ + +TD++    L E     PEE+ +  +E  
Sbjct: 289 PEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEET 348

Query: 368 LID-------ELSEDFDRSECKEKPSKPTE-----------KTEESKAAAPA------PV 403
           +++       E  E+  +S  K+ P  P E           + EE     P       P 
Sbjct: 349 ILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPD 408

Query: 404 SEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK-PVMDKVKEK- 461
                 T +   +   PEP   K +V +D +E           +P+ GK  + DK +++ 
Sbjct: 409 ETKPRETHVEFSKEDRPEPIKSKYSVGNDELE---------HREPKRGKLSLSDKFRKEY 459

Query: 462 ----AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLP---------PMSE 508
               +  E  E +G   E + P  +L  V ++      P ES+ +L           +S+
Sbjct: 460 YALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYS-DPSESQTELSEFVHEKEVVDLSQ 518

Query: 509 DFLLDALSEDFSGPQNASSLKFE 531
           +       +D + P+  + L+FE
Sbjct: 519 ELKERVSEDDETQPEKGTELQFE 541



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 79/332 (23%), Positives = 125/332 (37%), Gaps = 58/332 (17%)

Query: 273 PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 332
           PP+E K  V +D   + A+E           +P     ++ EV  A  +E  LE   E+ 
Sbjct: 137 PPEEAKPNVTEDVFLESAMET--------DPDPVPPTETMSEVSGATVRERNLELLEEET 188

Query: 333 ETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK-EKPSKPTEK 391
           E    E  L+   ++ G     EP E+ K    SE + E  E+ D    K  KP  P E 
Sbjct: 189 EPGVPEESLRVQHEETGL----EPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET 244

Query: 392 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 451
             ES                    ++ PPE A L+    +    +    L      PE+ 
Sbjct: 245 QRESTEKK----------------RTEPPEQARLEFLEKEPRKSSEEAGL----EPPEET 284

Query: 452 KP-VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDF 510
           +P V ++++ KA EE   +L E+ +   PD+        D KP   K + E +P   E+ 
Sbjct: 285 QPEVPEEMQRKATEEKGTELPERTK---PDF-------PDHKP--RKSTDENVPEPLEEI 332

Query: 511 LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDA 570
            L+   E+       + L+  +     +  E+         Q   PP +T      L   
Sbjct: 333 KLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQ---PPEETGPV---LPQE 386

Query: 571 LDKLSDSLGQRQPD------PDENKPMEDKVK 596
           ++   +   Q +P       PDE KP E  V+
Sbjct: 387 INPQVEEKTQTKPTEKILELPDETKPRETHVE 418



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 84/400 (21%), Positives = 147/400 (36%), Gaps = 56/400 (14%)

Query: 335 IPSEYRLKPATDKDGKPLLPEPEEKPKPRS--ESELIDELSEDFDR--SECKEKPSKPTE 390
           +P +Y   P  D+DG+ L PE  E P      E+   D +++   +  +E  ++P   TE
Sbjct: 4   VPEDYDSGP--DEDGE-LEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60

Query: 391 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 450
           + E+ K   P        +    S +    E    K  VP +    +   + K E   E 
Sbjct: 61  E-EDFKEGEPDSAKNVQLKPGGTSQEGIAKES---KRDVPSETEPGIHQEV-KSETSREM 115

Query: 451 GKPVMD---KVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-------- 499
           G+   D    + E  KE D E   E +  +  D  LE   + D  P+ P E+        
Sbjct: 116 GEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGAT 175

Query: 500 ----------KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 549
                     +E  P + E+ L     E    P   +   F   KL  ++ E   Q P  
Sbjct: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235

Query: 550 TTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGE 609
           T      P +T +             +S  +++ +P E   +E   KE  K+     L  
Sbjct: 236 TKP--ETPEETQR-------------ESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEP 280

Query: 610 RDDTIP--PE--YRHLLDDNGQDKPVK-PPTKKSEDSKKPADDQ--DPIDALSGDLDSCP 662
            ++T P  PE   R   ++ G + P +  P       +K  D+   +P++ +  +     
Sbjct: 281 PEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPE-E 339

Query: 663 STTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEET 702
            + +T++ T  ++ +     S         K + +  EET
Sbjct: 340 ESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEET 379


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.299    0.121    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,692,614
Number of Sequences: 37866
Number of extensions: 1829043
Number of successful extensions: 12834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 916
Number of HSP's that attempted gapping in prelim test: 8317
Number of HSP's gapped (non-prelim): 3877
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.