Search of human proteins with 9507165

Search of human proteins with 9507165

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9507165 syntrophin, gamma 2 [Homo sapiens]
         (539 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9507165 syntrophin, gamma 2 [Homo sapiens]                        1095   0.0  
gi|9507163 syntrophin, gamma 1 [Homo sapiens]                         505   e-143
gi|11321640 basic beta 1 syntrophin [Homo sapiens]                    156   5e-38
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                   153   4e-37
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                     142   1e-33
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    75   2e-13
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    75   2e-13
gi|148746189 multiple PDZ domain protein [Homo sapiens]                65   2e-10
gi|4759306 lin-7 homolog A [Homo sapiens]                              64   3e-10
gi|8922944 lin-7 homolog C [Homo sapiens]                              64   5e-10
gi|11545920 lin-7 homolog B [Homo sapiens]                             64   5e-10
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    63   6e-10
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    63   6e-10
gi|112382257 InaD-like [Homo sapiens]                                  63   8e-10
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    61   2e-09
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    61   2e-09
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    61   2e-09
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    61   3e-09
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      60   4e-09
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      60   4e-09
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       60   4e-09
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           59   9e-09
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           59   9e-09
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    59   1e-08
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    59   1e-08
gi|13376349 PDZ domain containing 7 [Homo sapiens]                     59   1e-08
gi|41281808 harmonin isoform b3 [Homo sapiens]                         58   2e-08
gi|71480164 harmonin isoform a [Homo sapiens]                          58   2e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    58   3e-08
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    58   3e-08

>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score = 1095 bits (2832), Expect = 0.0
 Identities = 539/539 (100%), Positives = 539/539 (100%)

Query: 1   MGTEGPPPPAASRGRQGCLLVPARTKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVV 60
           MGTEGPPPPAASRGRQGCLLVPARTKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVV
Sbjct: 1   MGTEGPPPPAASRGRQGCLLVPARTKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVV 60

Query: 61  CVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDA 120
           CVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDA
Sbjct: 61  CVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDA 120

Query: 121 VLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGAS 180
           VLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGAS
Sbjct: 121 VLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGAS 180

Query: 181 SPLFDSGLHLNGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLR 240
           SPLFDSGLHLNGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLR
Sbjct: 181 SPLFDSGLHLNGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLR 240

Query: 241 WNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHM 300
           WNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHM
Sbjct: 241 WNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHM 300

Query: 301 GWVNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKF 360
           GWVNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKF
Sbjct: 301 GWVNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKF 360

Query: 361 WLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRAT 420
           WLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRAT
Sbjct: 361 WLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRAT 420

Query: 421 FMEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTR 480
           FMEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTR
Sbjct: 421 FMEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTR 480

Query: 481 VKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDSQSLARKYMYSS 539
           VKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDSQSLARKYMYSS
Sbjct: 481 VKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDSQSLARKYMYSS 539


>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
          Length = 517

 Score =  505 bits (1300), Expect = e-143
 Identities = 260/511 (50%), Positives = 349/511 (68%), Gaps = 22/511 (4%)

Query: 25  TKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVVCVGGSHQGRNRRTVTLRRQPVGGL 84
           TKT I LL D   E  + +RL L K++L IQ+QDV+CV G       RTVT+RRQ VGG 
Sbjct: 10  TKTGICLLQDGNQE-PFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGF 68

Query: 85  GLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRNA 144
           GLSIKGG+EHN+PVV+SKI ++Q A+ +G+LF+GDA+LQ+NGI+V    HEEVV +LRNA
Sbjct: 69  GLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNA 128

Query: 145 GDEVTITVEYLREAPAFLKLPLGSPGPS--SDHSSGASSPLFDSGLHLNGNSSTTAPSSP 202
           G+EVT+TV +L+ APAFLKLPL        SD SSG SSPL DSGLHLN + + T   S 
Sbjct: 129 GEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSC 188

Query: 203 SS-PIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALDGVSSGILRFYT 261
           SS P +   R+EKRW D   +PL  +R S+Y  GT+  R NAF+V+A+DGV +GI++  +
Sbjct: 189 SSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLS 248

Query: 262 AQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHMGWVNEKLQGADSSQTFRPKFL 321
           A+D  DWL+A++ NI  LT  N+K  N+    + Q+V+MGW   + Q     + + P FL
Sbjct: 249 AEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFL 308

Query: 322 ALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTEDCWLQANLYLGLQDFDF 381
           AL+G   Y F  PPV+T+DW RAE+T+ + E++ K+                  L+D D 
Sbjct: 309 ALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKI------------------LKDSDL 350

Query: 382 EDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQRTGSRTYMCSWQGEML 441
            D+R  CF++ +  G+   F+VEL S+LA WE++FQ ATF+EV+R   +TY C  +  ++
Sbjct: 351 LDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLM 410

Query: 442 CFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIEMKELEFQ 501
             T+DF+ GF CF++ TK VLWR+KFSQLKGSSDDGK+++K LFQN DTKQIE KELEF 
Sbjct: 411 GLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFS 470

Query: 502 DLRAVLHCIHSFIAAKVASVDPGFMDSQSLA 532
           +L AVLHCIHSF AAKVA +DP F+ +Q+ A
Sbjct: 471 NLFAVLHCIHSFFAAKVACLDPLFLGNQATA 501


>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score =  156 bits (394), Expect = 5e-38
 Identities = 124/457 (27%), Positives = 217/457 (47%), Gaps = 44/457 (9%)

Query: 71  RRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVE 130
           +R V + +Q +GGLG+SIKGG E+ +P++ISKIF+  AADQT  L+VGDA+L VNG  + 
Sbjct: 110 KRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLR 169

Query: 131 NATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHL 190
           +ATH+E V  L+ AG EV + V+Y+REA  ++K   GSP        G  +P  +S    
Sbjct: 170 DATHDEAVQALKRAGKEVLLEVKYMREATPYVK--KGSP----VSEIGWETPPPES--PR 221

Query: 191 NGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALD 250
            G S++  PSS S    +D +         S+PL M  ++R  A  +       E+ + D
Sbjct: 222 LGGSTSDPPSSQSFSFHRDRK---------SIPLKMCYVTRSMALADPEN-RQLEIHSPD 271

Query: 251 GVSSGILRFYTAQDGTDWLRAVSANIRELTLQ-----NMKMANKCCSPSDQVVHMGWVNE 305
              + ILR   +     W  A+ +N+ +L  +       ++     + S ++ H+GW+ E
Sbjct: 272 AKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAE 331

Query: 306 KLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTED 365
           K+ G +S + ++P  + L      ++ + P     W     TY L           L   
Sbjct: 332 KVPG-ESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATR-------LVHS 383

Query: 366 CWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQ 425
              + +   G+ D  F  +      I     ++H+F  E   +L+ W +S  +      +
Sbjct: 384 GPGKGSPQAGV-DLSFATRTGTRQGI-----ETHLFRAETSRDLSHWTRSIVQGCHNSAE 437

Query: 426 RTGSRTYMCSWQGEMLCFTVDFALGFTCF----ESKTKNVLWRFKFSQLKGSSDDGKTRV 481
                +  C+++ +    T+ +  GF+      E      + +  + +LK SSDDG   +
Sbjct: 438 LIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDG---I 494

Query: 482 KLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518
           ++L+ +   K  E++       + ++  IHSF++AK+
Sbjct: 495 RMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKI 531


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score =  153 bits (386), Expect = 4e-37
 Identities = 133/460 (28%), Positives = 204/460 (44%), Gaps = 58/460 (12%)

Query: 71  RRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVE 130
           RR VT+R+   GGLG+SIKGG E+ +P++ISKIF+  AADQT  LFVGDA+L VNG  + 
Sbjct: 85  RRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLS 144

Query: 131 NATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHL 190
           +ATH+E V +L+  G EV + V+Y+++   + K   G  G S    S  +SPL       
Sbjct: 145 SATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTG--GTSVGWDSPPASPL------- 195

Query: 191 NGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALD 250
                      PSSP    PR    + +   + L MA +S+ +           E+ + D
Sbjct: 196 --------QRQPSSP-GPTPR---NFSEAKHMSLKMAYVSK-RCTPNDPEPRYLEICSAD 242

Query: 251 GVSSGILRFYTAQDGTDWLRAVSANIRELT------LQNMKMANKCCSPSDQVVHMGWVN 304
           G  +  LR         W  A+ A +  LT      LQ +  A       D +  +GW+ 
Sbjct: 243 GQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQD-IKQIGWLT 301

Query: 305 EKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTE 364
           E+L    ++    P    L      ++ + P +     R  RT  L              
Sbjct: 302 EQLPSGGTA----PTLALLTEKELLLYLSLPETREALSRPARTAPLIATRL--------- 348

Query: 365 DCWLQANLYLGLQDFDFEDQRPYCFSIVAG--HG-KSHVFNVELGSELAMWEKSFQRATF 421
              + +    G   +D E      F++  G  HG  +H+F+VE   ELA W +       
Sbjct: 349 ---VHSGPSKGSVPYDAE----LSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCH 401

Query: 422 MEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESK---TKNVLWRFKFSQLKGSSDDGK 478
              +     +  C+W G     +V    GFT + ++    + VL R  F +L+ SSDDG 
Sbjct: 402 RAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDG- 460

Query: 479 TRVKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518
               LLF +    + E++       + ++  IHSF++AKV
Sbjct: 461 --ASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKV 498


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score =  142 bits (357), Expect = 1e-33
 Identities = 123/458 (26%), Positives = 201/458 (43%), Gaps = 49/458 (10%)

Query: 72  RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
           R V + +Q  GGLG+SIKGG E+ +P++ISKIF   AADQ+  L +GDA+L VNG  +  
Sbjct: 114 RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173

Query: 132 ATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLN 191
           ATH++ V  L+ AG EV + V+++RE   ++K                  P   S L   
Sbjct: 174 ATHDQAVQALKRAGKEVLLEVKFIREVTPYIK-----------------KPSLVSDLPWE 216

Query: 192 GNSSTTAPSSPSSPIAKD---PRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLA 248
           G     AP SPS   ++D   P+++    D   +PL M   +R       L     E+ +
Sbjct: 217 G----AAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAAR-NLSMPDLENRLIELHS 271

Query: 249 LDGVSSGILRFYTAQDGTDWLRAVSANIREL------TLQNMKMANKCCSPSDQVVHMGW 302
            D  ++ ILR         W  A+  NI  L       L  M  A      S +V H+ W
Sbjct: 272 PDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAW 331

Query: 303 VNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWL 362
           + E+ +     Q +RP  +A+      ++   P +   W     +Y L      VH    
Sbjct: 332 LAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRL-VHS--- 387

Query: 363 TEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFM 422
              C    +  LG  D  F  +      I     + H+F VE   +L+ W +   +    
Sbjct: 388 GSGC---RSPSLG-SDLTFATRTGSRQGI-----EMHLFRVETHRDLSSWTRILVQGCHA 438

Query: 423 EVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESK--TKNVLWRFKFSQLKGSSDDGKTR 480
             +     +  C   G+ +  T+ +  GFT       + ++L+R+ F +LK S+DDG   
Sbjct: 439 AAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDG--- 495

Query: 481 VKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518
           ++ L+ +    + E+        + ++  +H+F++AKV
Sbjct: 496 IRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKV 533


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 37/84 (44%), Positives = 53/84 (63%)

Query: 72  RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
           R V L ++   GLG+SI GG EH VP++IS+I   Q AD+ G L VGDA+L VNG+++ +
Sbjct: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346

Query: 132 ATHEEVVHLLRNAGDEVTITVEYL 155
             H+E V +L     E+   V Y+
Sbjct: 347 TKHKEAVTILSQQRGEIEFEVVYV 370


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 37/84 (44%), Positives = 53/84 (63%)

Query: 72  RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
           R V L ++   GLG+SI GG EH VP++IS+I   Q AD+ G L VGDA+L VNG+++ +
Sbjct: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338

Query: 132 ATHEEVVHLLRNAGDEVTITVEYL 155
             H+E V +L     E+   V Y+
Sbjct: 339 TKHKEAVTILSQQRGEIEFEVVYV 362


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/78 (43%), Positives = 53/78 (67%), Gaps = 2/78 (2%)

Query: 83   GLGLSIKGGSEHNV-PVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141
            GLGLSI GGS+  +  ++I +++E+ AA + G L+ GD +L+VNGI +  ATH+E +++L
Sbjct: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697

Query: 142  RNAGDEVTITVEYLREAP 159
            R     V +T+ Y  EAP
Sbjct: 1698 RQTPQRVRLTL-YRDEAP 1714



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 13/148 (8%)

Query: 72   RTVTLRRQPVGGLGLSIKGG---------SEHNVPVVISKIFEDQAADQTGMLFVGDAVL 122
            R V L R+P   LG+SI GG          E    + I  + ED  A + G L  GD ++
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209

Query: 123  QVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSP 182
            +V+G+ + +A+HE+ V  +R AG+ V   V+ +   P    LP         ++  +++P
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNP 1269

Query: 183  LFDSGLHLNGNSSTTAPSSPSSPIAKDP 210
              DS L +N +    APS   S   K P
Sbjct: 1270 FADS-LQINADK---APSQSESEPEKAP 1293



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 34/84 (40%), Positives = 49/84 (58%), Gaps = 4/84 (4%)

Query: 72   RTVTLRRQPVGGLGLSIKGG--SEH-NVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
            +++TL R P  GLG SI GG  S H ++P+ +  +F   AA + G L  GD ++ VNG  
Sbjct: 1957 KSITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015

Query: 129  VENATHEEVVHLLRNAGDEVTITV 152
            +E  THEE V +L+     VT+ V
Sbjct: 2016 LEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 30/84 (35%), Positives = 46/84 (54%), Gaps = 3/84 (3%)

Query: 72   RTVTLRRQPVGGLGLSIKGGSEH---NVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
            RTV +++ P   LG+SI GG      +VP+ I+ +     A QT  L VGD ++ + G  
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891

Query: 129  VENATHEEVVHLLRNAGDEVTITV 152
             E  TH + V+LL+NA   + + V
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 31/70 (44%), Positives = 41/70 (58%), Gaps = 1/70 (1%)

Query: 73   TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
            T+ L+++P  GLGLSI G   ++  V +S I +   AD  G L  GD +L VNG  V NA
Sbjct: 1725 TIELQKKPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783

Query: 133  THEEVVHLLR 142
            T E V  LL+
Sbjct: 1784 TQEAVAALLK 1793



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 6/119 (5%)

Query: 67  QGRNRRTVTLRRQPVGGLGLSIKGGSEHN---VPVVISKIFEDQAADQTGMLFVGDAVLQ 123
           QGR+     L + P GGLG S+ G    N   + + + +I E   A + G L   D +L 
Sbjct: 131 QGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILA 190

Query: 124 VNGIHVENA-THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASS 181
           +NG  ++   TH++ + +L+ A D V + +   R +   L  P+ S  PS+  +  A S
Sbjct: 191 INGQALDQTITHQQAISILQKAKDTVQLVI--ARGSLPQLVSPIVSRSPSAASTISAHS 247



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 23/68 (33%), Positives = 39/68 (57%), Gaps = 3/68 (4%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG+S++    H+    I  +  +     +G LF GD +L+VNGI +    H++VV++L+
Sbjct: 564 GLGISLEATVGHHF---IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620

Query: 143 NAGDEVTI 150
               EVT+
Sbjct: 621 ELPIEVTM 628



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 22/76 (28%), Positives = 44/76 (57%), Gaps = 4/76 (5%)

Query: 81  VGGLGLSIKG--GSEHNVP--VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEE 136
           V GLG++I G  G +   P  + +  I +  A +  G + +GD ++ V+G +++  T+++
Sbjct: 384 VQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443

Query: 137 VVHLLRNAGDEVTITV 152
            V +LR+ G  V +T+
Sbjct: 444 AVEVLRHTGQTVLLTL 459



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 35/120 (29%), Positives = 49/120 (40%), Gaps = 13/120 (10%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG  I GG    V  ++  I     ADQ G L  GD +L++    +   + E+V  +LR
Sbjct: 266 GLGFGIIGGKATGV--IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323

Query: 143 NAGDEVTITVE----YLREAPAFLKLPLGSPGPSSDH-------SSGASSPLFDSGLHLN 191
             G+ V + +       R AP  L + L S   S+           G  S  FD  L  N
Sbjct: 324 QCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKN 383



 Score = 37.0 bits (84), Expect = 0.046
 Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 18/140 (12%)

Query: 83  GLGLSIKGGSEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVV 138
           GLG SI    +   P    ++I  +     A++ G L  GD ++ VN +++EN++ EE V
Sbjct: 709 GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAV 768

Query: 139 HLLRNAGDEVTITVEYLREAP-----AFLKLPLGS---PGPSSDHSSGASSPLFDSGLHL 190
             L+ A    T+ +   +  P      ++     S   P  S + +  A  PLF + L L
Sbjct: 769 EALKGA-PSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLAL 827

Query: 191 NGNSST-----TAPSSPSSP 205
            G +       +   SP SP
Sbjct: 828 VGTNDADLVDESTFESPYSP 847



 Score = 37.0 bits (84), Expect = 0.046
 Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 8/132 (6%)

Query: 82   GGLGLSIKGGSEHNV--PVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVH 139
            GGLG++I   SE +    V+I  + E   A   G L VGD +L V+   V     E+ + 
Sbjct: 1491 GGLGIAI---SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFIS 1547

Query: 140  LLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLF-DSGLHLNGNSSTTA 198
            LL+ A   V +T+    E P    +P  +   S +  + + S +   SG     +   T+
Sbjct: 1548 LLKTAKMTVKLTIH--AENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605

Query: 199  PSSPSSPIAKDP 210
             SS  +  A DP
Sbjct: 1606 RSSTPAIFASDP 1617



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 21/69 (30%), Positives = 38/69 (55%), Gaps = 1/69 (1%)

Query: 83   GLGLSIKGGSEHN-VPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141
            GLGLS+ G  + + + V I  I  + AA + G L + D +L++NG  +   +H+    ++
Sbjct: 1359 GLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSII 1418

Query: 142  RNAGDEVTI 150
            + A  +V I
Sbjct: 1419 KCAPSKVKI 1427


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 32/72 (44%), Positives = 43/72 (59%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG ++ GG E N P+ IS+I     A++ G L  GD +L VNG+ VE   HE+ V LL+
Sbjct: 117 GLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 176

Query: 143 NAGDEVTITVEY 154
            A D V + V Y
Sbjct: 177 AAKDSVKLVVRY 188


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 33/72 (45%), Positives = 43/72 (59%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E N P+ IS+I     AD+ G L  GD +L VNG+ VE   HE+ V LL+
Sbjct: 102 GLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 161

Query: 143 NAGDEVTITVEY 154
            A  +V + V Y
Sbjct: 162 AAQGKVKLVVRY 173


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 32/72 (44%), Positives = 42/72 (58%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E N P+ IS++     AD+ G L  GD +L VNG+ VE   HE+ V LL+
Sbjct: 102 GLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLK 161

Query: 143 NAGDEVTITVEY 154
            A   V + V Y
Sbjct: 162 AAQGSVKLVVRY 173


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 56/197 (28%), Positives = 88/197 (44%), Gaps = 29/197 (14%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPVG---------- 82
           A D RL++   +L + + DV  V  S         G   R   +RR+P            
Sbjct: 149 AQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 208

Query: 83  ---GLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI E  AA + G L +GD +L VN + +E+  H
Sbjct: 209 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMH 268

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
           E+ V  L+N  D V + V   + + A+L      P  ++ +S    + +  S        
Sbjct: 269 EDAVAALKNTYDVVYLKV--AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP 326

Query: 195 STTAPSSPS--SPIAKD 209
           +   P+SP   SP+AKD
Sbjct: 327 TAMTPTSPRRYSPVAKD 343



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 36/89 (40%), Positives = 48/89 (53%), Gaps = 2/89 (2%)

Query: 69  RNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
           R  R + + R   G LG +I GG E    + IS I     AD +G L  GD +L VNG+ 
Sbjct: 352 REPRRIVIHRGSTG-LGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVD 409

Query: 129 VENATHEEVVHLLRNAGDEVTITVEYLRE 157
           + NA+HE+    L+NAG  VTI  +Y  E
Sbjct: 410 LRNASHEQAAIALKNAGQTVTIIAQYKPE 438


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 56/197 (28%), Positives = 88/197 (44%), Gaps = 29/197 (14%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPVG---------- 82
           A D RL++   +L + + DV  V  S         G   R   +RR+P            
Sbjct: 103 AQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 162

Query: 83  ---GLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI E  AA + G L +GD +L VN + +E+  H
Sbjct: 163 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMH 222

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
           E+ V  L+N  D V + V   + + A+L      P  ++ +S    + +  S        
Sbjct: 223 EDAVAALKNTYDVVYLKV--AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYP 280

Query: 195 STTAPSSPS--SPIAKD 209
           +   P+SP   SP+AKD
Sbjct: 281 TAMTPTSPRRYSPVAKD 297



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 36/89 (40%), Positives = 48/89 (53%), Gaps = 2/89 (2%)

Query: 69  RNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
           R  R + + R   G LG +I GG E    + IS I     AD +G L  GD +L VNG+ 
Sbjct: 306 REPRRIVIHRGSTG-LGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVD 363

Query: 129 VENATHEEVVHLLRNAGDEVTITVEYLRE 157
           + NA+HE+    L+NAG  VTI  +Y  E
Sbjct: 364 LRNASHEQAAIALKNAGQTVTIIAQYKPE 392


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 34/97 (35%), Positives = 52/97 (53%), Gaps = 9/97 (9%)

Query: 72   RTVTLRRQPVGGLGLSIKGGS---------EHNVPVVISKIFEDQAADQTGMLFVGDAVL 122
            R V + R+P   LG+SI GG          E    + I ++ ED  A +T  L  GD +L
Sbjct: 1067 RIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1126

Query: 123  QVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAP 159
            +V+G+ ++NA+H E V  ++NAG+ V   V+ L   P
Sbjct: 1127 EVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 29/71 (40%), Positives = 47/71 (66%), Gaps = 1/71 (1%)

Query: 83   GLGLSIKGGSEHNV-PVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141
            GLGLSI GG +  +  +VI +++E+ AA + G L+ GD +L+VNG+ + N++HEE +  L
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505

Query: 142  RNAGDEVTITV 152
            R    +V + V
Sbjct: 1506 RQTPQKVRLVV 1516



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 38/105 (36%), Positives = 50/105 (47%), Gaps = 13/105 (12%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG  I GG    V  V+  I     AD+ G L  GD +L++ G +V+  T E+V  +LR
Sbjct: 257 GLGFGIVGGKTSGV--VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314

Query: 143 NAGDEVTITV--------EYLREAPAFLKLPL---GSPGPSSDHS 176
           N G+ V + V             APA L + L    S GP SD S
Sbjct: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 6/143 (4%)

Query: 74   VTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENAT 133
            V L+++   GLGLSI G   +   V IS I +  AAD  G L  GD +L VNG  + NA+
Sbjct: 1534 VDLQKKAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592

Query: 134  HEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGAS-----SPLFDSGL 188
             E V  +L+ A   V + +  LR                S  S+ +S     +P+     
Sbjct: 1593 QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQ 1652

Query: 189  HLNGNSSTTAPSSPSSPIAKDPR 211
            +L G    + PS  +S    +PR
Sbjct: 1653 NLVGTKRVSDPSQKNSGTDMEPR 1675



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 3/84 (3%)

Query: 72   RTVTLRRQPVGGLGLSIKGGSEH---NVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
            RTV + R+    LG+SI GG      ++PV I+ I     A +T  L VGD ++ +NG  
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734

Query: 129  VENATHEEVVHLLRNAGDEVTITV 152
            ++  +H +VV+LL+NA   + + V
Sbjct: 1735 LDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 11/128 (8%)

Query: 74  VTLRRQPVGGLGLSIKG--GSEHNVP---VVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
           V L R+    LG+ I G  G+ H      + +  I    AA   G + V D ++ V+G++
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425

Query: 129 VENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGL 188
           ++   + +VV +LRNAG  V +T+  +R   +    PL    P SD  +    PL    L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTL--VRRKTSSSTSPL---EPPSDRGT-VVEPLKPPAL 479

Query: 189 HLNGNSST 196
            L G   T
Sbjct: 480 FLTGAVET 487



 Score = 36.2 bits (82), Expect = 0.078
 Identities = 24/105 (22%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 83   GLGLSIKGGSEHN-VPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141
            GLGLS+ G  + + + + +  I  +  A   G + +GD +L++N   +   +H+    ++
Sbjct: 1248 GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAII 1307

Query: 142  RNAGDEVTITVEYLREA---PAFLKLPLGSPGPSSDHSSGASSPL 183
            + A  +V +      +A    A    P+ S  PSS      + P+
Sbjct: 1308 KTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPI 1352



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 67  QGRNRRTVTLRRQPVGGLGLSIKGGSEHN---VPVVISKIFEDQAADQTGMLFVGDAVLQ 123
           QGR    + + R   GGLG S+      N   V + +  +     AD+   L   D +L 
Sbjct: 128 QGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILA 187

Query: 124 VNGIHV-ENATHEEVVHLLRNAGDEVTITV 152
           +N   + +N +H++ + LL+     + + V
Sbjct: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIV 217



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 4/64 (6%)

Query: 83  GLGLSIKGGSEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVV 138
           GLG SI    +   P    +VI  +  D  A+++G L  GD ++ VN   ++N +  E V
Sbjct: 695 GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAV 754

Query: 139 HLLR 142
            +L+
Sbjct: 755 EILK 758


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
           containing 2 [Homo sapiens]
          Length = 1455

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 13/137 (9%)

Query: 74  VTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENAT 133
           V LRR    G G  I GG E   P++I  +    +AD+ G L  GD ++ V+GI V   T
Sbjct: 779 VHLRRME-SGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKT 837

Query: 134 HEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGA-----SSPLFDSGL 188
           H  V+ L+ +A     + +   R+      L  G P P +  S G+     SSP  D   
Sbjct: 838 HRYVIDLMHHAARNGQVNLTVRRKV-----LCGGEPCPENGRSPGSVSTHHSSPRSDYAT 892

Query: 189 HLNGNSSTTAPSSPSSP 205
           + N N +  APSS +SP
Sbjct: 893 YTNSNHA--APSSNASP 907



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/132 (26%), Positives = 68/132 (51%), Gaps = 9/132 (6%)

Query: 83   GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
            G G SI+GG E+ + + + ++ ED  A + G + VGD ++++NG    + TH   + L++
Sbjct: 1156 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215

Query: 143  NAGDEVTITVEY-LREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNSSTTAPSS 201
            + G  V + ++    + P +       P P S  ++ A   L + G+ L+   +  +PS 
Sbjct: 1216 SGGRRVRLLLKRGTGQVPEY-----DEPAPWSSPAAAAPG-LPEVGVSLDDGLAPFSPSH 1269

Query: 202  PSSPIAKDPRYE 213
            P+ P   DP ++
Sbjct: 1270 PAPP--SDPSHQ 1279



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 42/142 (29%), Positives = 64/142 (45%), Gaps = 16/142 (11%)

Query: 74   VTLRRQPVGGLGLSI-------KGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
            V + R+   G G  I       + GS   VP  I +I +   AD+   L VGD +L VNG
Sbjct: 921  VVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNG 980

Query: 127  IHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDS 186
              + N  H ++V L+++AG  VT+ +    E    L  P  +P           SPL   
Sbjct: 981  QSIINMPHADIVKLIKDAGLSVTLRIIPQEE----LNSPTSAPSSEKQSPMAQQSPLAQ- 1035

Query: 187  GLHLNGNSSTTAPSSPSSPIAK 208
                    +  +P++P+SPIA+
Sbjct: 1036 ----QSPLAQPSPATPNSPIAQ 1053



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 5/101 (4%)

Query: 73  TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
           + TL++  +G  G +I GG E +  + +  +  D  A Q G +  GD ++ +N + V   
Sbjct: 426 STTLKKSNMG-FGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484

Query: 133 THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSS 173
           TH +VV L ++     ++ +   R  P    LP     P++
Sbjct: 485 THADVVKLFQSVPIGQSVNLVLCRGYP----LPFDPEDPAN 521



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 21/87 (24%), Positives = 42/87 (48%), Gaps = 1/87 (1%)

Query: 65  SHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVG-DAVLQ 123
           SH         + R P G LG  +KGG+E+     + ++   + A ++G   V  + +L+
Sbjct: 9   SHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLE 68

Query: 124 VNGIHVENATHEEVVHLLRNAGDEVTI 150
           VN   V   T  +V+ ++++  D + +
Sbjct: 69  VNETPVAGLTIRDVLAVIKHCKDPLRL 95



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 17/89 (19%)

Query: 118 GDAVLQVNGIHVENATHEEVVHLLRNA--GDEVTITVEYLREAPAFLKLPLGSPGPSSDH 175
           GD ++++N  +V+N +H EVV +L++   G E ++ +        F   P  +P P  D 
Sbjct: 643 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII----HRGGFFS-PWKTPKPIMDR 697

Query: 176 SSGASSPLFDSGLHLNGNSSTTAPSSPSS 204
                SP           +S +AP+ P +
Sbjct: 698 WENQGSP----------QTSLSAPAIPQN 716


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 14/113 (12%)

Query: 73   TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
            TV L R    G G S++GG E+N+ + + ++ ED  A++ G + +GD +L++NG   +N 
Sbjct: 1123 TVELERG-AKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1181

Query: 133  THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSP---GPSSDHSSGASSP 182
             H   + L++N G  V +          FLK   GS     PSSD    A+ P
Sbjct: 1182 KHSRAIELIKNGGRRVRL----------FLKRGDGSVPEYDPSSDRHGPATGP 1224



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 3/99 (3%)

Query: 54   IQKQDVVCVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG 113
            +Q  DV    G ++G     V+   +P  G      G +   +P  I +I E   AD+ G
Sbjct: 966  VQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTF---GNACVAMPHKIGRIIEGSPADRCG 1022

Query: 114  MLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITV 152
             L VGD +L VNG  + N +H ++V+L++ AG+ VT+ +
Sbjct: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           G G  I GG+E   P+ I  I    AAD  G L  GD ++ V+G  V   +H+ VV L++
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 881

Query: 143 NAGDEVTITVEYLREAP-AFLKLPLGSPGPSSDHSS 177
            A  +  + +   R+   A  K     P P+S H S
Sbjct: 882 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS 917



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 5/134 (3%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
           T  R+   G G ++ GG E +  + I  +  D  A   G +  GD ++ VN   V   TH
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTH 532

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
            +VV + ++     ++ +E  R  P    LP     P++   +  +  L    + +NG  
Sbjct: 533 AQVVKIFQSIPIGASVDLELCRGYP----LPFDPDDPNTSLVTSVAI-LDKEPIIVNGQE 587

Query: 195 STTAPSSPSSPIAK 208
           +  +P+S SS   K
Sbjct: 588 TYDSPASHSSKTGK 601



 Score = 37.4 bits (85), Expect = 0.035
 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG-----MLFVGDAVLQVNGIHV 129
           T++R P G LG+++ GG+EH     +  +   +AA   G      L  G+ +L+V G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 130 ENATHEEVVHLLRNAGDEVT 149
                 +V+ ++ +  + VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 34/120 (28%), Positives = 47/120 (39%), Gaps = 16/120 (13%)

Query: 118 GDAVLQVNGIHVENATHEEVVHLLRNA--GDEVTITVEYLREAPAFLKLPLGSPGPSSD- 174
           GD +++VN  +V+  TH +VV +L     G EVT+ V+     P   K P   P    D 
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ-RGGLPVPKKSPKSQPLERKDS 741

Query: 175 HSSGASSPLFDSGLHLNGNSSTT------------APSSPSSPIAKDPRYEKRWLDTLSV 222
            +S   S      LH    S +T            AP    S   K P   K W  + S+
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 35/132 (26%), Positives = 71/132 (53%), Gaps = 6/132 (4%)

Query: 73   TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
            TV L R    G G S++GG E+N+ + + ++ ED  A++ G + +GD +L++NG   +N 
Sbjct: 1151 TVELERG-AKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1209

Query: 133  THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNG 192
             H   + L++N G  V +   +L+       +P  +  P +  +   +  L ++  +L G
Sbjct: 1210 KHSRAIELIKNGGRRVRL---FLKRGDG--SVPEYAMIPPNIAACMRNEKLGEACFYLMG 1264

Query: 193  NSSTTAPSSPSS 204
            ++ TT P++ ++
Sbjct: 1265 HNQTTTPAATAT 1276



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 3/99 (3%)

Query: 54   IQKQDVVCVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG 113
            +Q  DV    G ++G     V+   +P  G      G +   +P  I +I E   AD+ G
Sbjct: 994  VQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTF---GNACVAMPHKIGRIIEGSPADRCG 1050

Query: 114  MLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITV 152
             L VGD +L VNG  + N +H ++V+L++ AG+ VT+ +
Sbjct: 1051 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           G G  I GG+E   P+ I  I    AAD  G L  GD ++ V+G  V   +H+ VV L++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909

Query: 143 NAGDEVTITVEYLREAP-AFLKLPLGSPGPSSDHSS 177
            A  +  + +   R+   A  K     P P+S H S
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS 945



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 5/134 (3%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
           T  R+   G G ++ GG E +  + I  +  D  A   G +  GD ++ VN   V   TH
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTH 532

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
            +VV + ++     ++ +E  R  P    LP     P++   +  +  L    + +NG  
Sbjct: 533 AQVVKIFQSIPIGASVDLELCRGYP----LPFDPDDPNTSLVTSVAI-LDKEPIIVNGQE 587

Query: 195 STTAPSSPSSPIAK 208
           +  +P+S SS   K
Sbjct: 588 TYDSPASHSSKTGK 601



 Score = 37.4 bits (85), Expect = 0.035
 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG-----MLFVGDAVLQVNGIHV 129
           T++R P G LG+++ GG+EH     +  +   +AA   G      L  G+ +L+V G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 130 ENATHEEVVHLLRNAGDEVT 149
                 +V+ ++ +  + VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 39/145 (26%), Positives = 56/145 (38%), Gaps = 20/145 (13%)

Query: 118 GDAVLQVNGIHVENATHEEVVHLLRNA--GDEVTITVEYLREAPAFLKLPLGSPGPSSD- 174
           GD +++VN  +V+  TH +VV +L     G EVT+ V+     P   K P   P    D 
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ-RGGLPVPKKSPKSQPLERKDS 741

Query: 175 HSSGASSPLFDSGLHLNGNSSTT------------APSSPSSPIAKDPRYEKRWLDTLSV 222
            +S   S      LH    S +T            AP    S   K P   K W  + S+
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801

Query: 223 ----PLSMARISRYKAGTEKLRWNA 243
               P+S +  S    G  +   N+
Sbjct: 802 YENRPMSPSPASGLSKGEREREINS 826


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 12/126 (9%)

Query: 69  RNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIH 128
           R    V L ++    LGL+I GG++ +    +S +     A ++ +L +GD +  VNGIH
Sbjct: 141 RGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIH 200

Query: 129 VENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGL 188
           +    H+E++ LL+N G+ V + VEY              P P+ +++    S   D  L
Sbjct: 201 LTRLRHDEIITLLKNVGERVVLEVEY------------ELPPPAPENNPRIISKTVDVSL 248

Query: 189 HLNGNS 194
           +  GNS
Sbjct: 249 YKEGNS 254



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 36/102 (35%), Positives = 58/102 (56%), Gaps = 2/102 (1%)

Query: 73  TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
           TV L+R   G LG++I G  E   P+VIS + +   A++TG + VGD +L +N + ++  
Sbjct: 754 TVELKRYG-GPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGR 812

Query: 133 THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSD 174
              E +HLL+ AG+ VT+ ++   + P  L    GS   +SD
Sbjct: 813 PLSEAIHLLQVAGETVTLKIKKQLDRP-LLPRKSGSLSETSD 853



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 6/98 (6%)

Query: 63  GGSHQGRNRRTVTLRRQPVGGLGLSIKGG----SEHNVPVVISKIFEDQAADQTGMLFVG 118
           GG         V L   P+ G GL ++GG       + P ++  I  D  A++ G+L VG
Sbjct: 544 GGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVG 603

Query: 119 DAVLQVNGIHVENATHEEVVHLLRNA--GDEVTITVEY 154
           D VL +NGI  E+ T EE   LLR+A    +V + VE+
Sbjct: 604 DRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEF 641



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 84  LGLSIKGGS-EHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           LG++I   S +   P++IS I +   A +TG L  GD +L ++ I ++N   E+ V +LR
Sbjct: 666 LGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725

Query: 143 NAGDEVTITV 152
              D V + +
Sbjct: 726 QCEDLVKLKI 735



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 4/74 (5%)

Query: 85  GLSIKGGSEHNV----PVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHL 140
           G  ++GG+  +     P+V++ +     AD+ G L VGD +L V+GI +  A+H   +  
Sbjct: 256 GFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALAT 315

Query: 141 LRNAGDEVTITVEY 154
           LR    E    VEY
Sbjct: 316 LRQCSHEALFQVEY 329


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 55/193 (28%), Positives = 85/193 (44%), Gaps = 33/193 (17%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPV----------- 81
           A D RL++   +L + + DV  V  S         G   R    RR+P+           
Sbjct: 88  AEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK 147

Query: 82  --GGLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI +  AA + G L VGD +L VN   +E  TH
Sbjct: 148 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTH 207

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
           EE V +L+N  + V + V   +    ++  P G P  +  +S    + L      L+GN+
Sbjct: 208 EEAVAILKNTSEVVYLKVG--KPTTIYMTDPYGPPDITHSYSPPMENHL------LSGNN 259

Query: 195 STTAPSSPSSPIA 207
            T    +   PI+
Sbjct: 260 GTLEYKTSLPPIS 272



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 1/75 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E    + +S I     AD +G L  GD +L VNGI +  A+HE+    L+
Sbjct: 327 GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385

Query: 143 NAGDEVTITVEYLRE 157
            AG  VTI  +Y  E
Sbjct: 386 GAGQTVTIIAQYQPE 400


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 55/193 (28%), Positives = 85/193 (44%), Gaps = 33/193 (17%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPV----------- 81
           A D RL++   +L + + DV  V  S         G   R    RR+P+           
Sbjct: 244 AEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK 303

Query: 82  --GGLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI +  AA + G L VGD +L VN   +E  TH
Sbjct: 304 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTH 363

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
           EE V +L+N  + V + V   +    ++  P G P  +  +S    + L      L+GN+
Sbjct: 364 EEAVAILKNTSEVVYLKVG--KPTTIYMTDPYGPPDITHSYSPPMENHL------LSGNN 415

Query: 195 STTAPSSPSSPIA 207
            T    +   PI+
Sbjct: 416 GTLEYKTSLPPIS 428



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 1/75 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E    + +S I     AD +G L  GD +L VNGI +  A+HE+    L+
Sbjct: 535 GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593

Query: 143 NAGDEVTITVEYLRE 157
            AG  VTI  +Y  E
Sbjct: 594 GAGQTVTIIAQYQPE 608


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 55/193 (28%), Positives = 85/193 (44%), Gaps = 33/193 (17%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPV----------- 81
           A D RL++   +L + + DV  V  S         G   R    RR+P+           
Sbjct: 139 AEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK 198

Query: 82  --GGLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI +  AA + G L VGD +L VN   +E  TH
Sbjct: 199 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTH 258

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
           EE V +L+N  + V + V   +    ++  P G P  +  +S    + L      L+GN+
Sbjct: 259 EEAVAILKNTSEVVYLKVG--KPTTIYMTDPYGPPDITHSYSPPMENHL------LSGNN 310

Query: 195 STTAPSSPSSPIA 207
            T    +   PI+
Sbjct: 311 GTLEYKTSLPPIS 323



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 1/75 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E    + +S I     AD +G L  GD +L VNGI +  A+HE+    L+
Sbjct: 430 GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488

Query: 143 NAGDEVTITVEYLRE 157
            AG  VTI  +Y  E
Sbjct: 489 GAGQTVTIIAQYQPE 503


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 62/198 (31%), Positives = 94/198 (47%), Gaps = 39/198 (19%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPVG---------- 82
           A D RL++   +L + + DV  V  S         G   R    RR+PV           
Sbjct: 265 AQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIK 324

Query: 83  ---GLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI E  AA + G L +GD +L VN + +E  TH
Sbjct: 325 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTH 384

Query: 135 EEVVHLLRNAGDEVTITVEYLREA-PAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGN 193
           EE V  L+N  D V     YL+ A P  + +  G   P  D ++ +S P+ +   H++ +
Sbjct: 385 EEAVTALKNTSDFV-----YLKVAKPTSMYMNDGYAPP--DITNSSSQPVDN---HVSPS 434

Query: 194 SST-TAPSSPS--SPIAK 208
           S     P+SP+  SP++K
Sbjct: 435 SFLGQTPASPARYSPVSK 452



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/96 (37%), Positives = 48/96 (50%), Gaps = 2/96 (2%)

Query: 62  VGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAV 121
           +G     R  R V L R   G LG +I GG E    + IS I     AD +G L  GD +
Sbjct: 455 LGDDEITREPRKVVLHRGSTG-LGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRI 512

Query: 122 LQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLRE 157
           + VN + +  A+HE+    L+NAG  VTI  +Y  E
Sbjct: 513 ISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPE 548



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 6/97 (6%)

Query: 62  VGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEH-----NVPVVISKIFEDQAADQTGMLF 116
           V G+        +TL R    GLG SI GG+++     +  + I+KI    AA Q G L 
Sbjct: 213 VNGTDADYEYEEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLR 271

Query: 117 VGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITVE 153
           V D +L+VN + V + TH + V  L+ AG  V + V+
Sbjct: 272 VNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 62/198 (31%), Positives = 94/198 (47%), Gaps = 39/198 (19%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGS-------HQGRNRRTVTLRRQPVG---------- 82
           A D RL++   +L + + DV  V  S         G   R    RR+PV           
Sbjct: 265 AQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIK 324

Query: 83  ---GLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + ++KI E  AA + G L +GD +L VN + +E  TH
Sbjct: 325 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTH 384

Query: 135 EEVVHLLRNAGDEVTITVEYLREA-PAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGN 193
           EE V  L+N  D V     YL+ A P  + +  G   P  D ++ +S P+ +   H++ +
Sbjct: 385 EEAVTALKNTSDFV-----YLKVAKPTSMYMNDGYAPP--DITNSSSQPVDN---HVSPS 434

Query: 194 SST-TAPSSPS--SPIAK 208
           S     P+SP+  SP++K
Sbjct: 435 SFLGQTPASPARYSPVSK 452



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/96 (37%), Positives = 48/96 (50%), Gaps = 2/96 (2%)

Query: 62  VGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAV 121
           +G     R  R V L R   G LG +I GG E    + IS I     AD +G L  GD +
Sbjct: 455 LGDDEITREPRKVVLHRGSTG-LGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRI 512

Query: 122 LQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLRE 157
           + VN + +  A+HE+    L+NAG  VTI  +Y  E
Sbjct: 513 ISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPE 548



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 6/97 (6%)

Query: 62  VGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEH-----NVPVVISKIFEDQAADQTGMLF 116
           V G+        +TL R    GLG SI GG+++     +  + I+KI    AA Q G L 
Sbjct: 213 VNGTDADYEYEEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLR 271

Query: 117 VGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITVE 153
           V D +L+VN + V + TH + V  L+ AG  V + V+
Sbjct: 272 VNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 32/75 (42%), Positives = 43/75 (57%), Gaps = 1/75 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E    + +S I     AD +G L  GD +L VNG+++ NATHE+    L+
Sbjct: 58  GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 116

Query: 143 NAGDEVTITVEYLRE 157
            AG  VTI  +Y  E
Sbjct: 117 RAGQSVTIVAQYRPE 131


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 32/75 (42%), Positives = 43/75 (57%), Gaps = 1/75 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG +I GG E    + +S I     AD +G L  GD +L VNG+++ NATHE+    L+
Sbjct: 395 GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453

Query: 143 NAGDEVTITVEYLRE 157
            AG  VTI  +Y  E
Sbjct: 454 RAGQSVTIVAQYRPE 468



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 47/138 (34%), Positives = 63/138 (45%), Gaps = 25/138 (18%)

Query: 40  AYDIRLKLTKEVLTIQKQDVVCVGGSHQ-------GRNRRTVTLRRQPVG---------- 82
           A D RL +   VL + + DV  V  S         G   R V  RRQP            
Sbjct: 172 AMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLK 231

Query: 83  ---GLGLSIKGG-SEHNVP----VVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
              GLG SI GG    ++P    + I+KI E  AA + G L +GD +L VN  ++++  H
Sbjct: 232 GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRH 291

Query: 135 EEVVHLLRNAGDEVTITV 152
           EE V  L+N  D V + V
Sbjct: 292 EEAVASLKNTSDMVYLKV 309


>gi|13376349 PDZ domain containing 7 [Homo sapiens]
          Length = 517

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 27/72 (37%), Positives = 47/72 (65%), Gaps = 1/72 (1%)

Query: 73  TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
           +V + + P G LG S++GGSEH + + +SK+ E  +A++ G L VGD + +VNG+ +E+ 
Sbjct: 86  SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAG-LCVGDKITEVNGLSLEST 144

Query: 133 THEEVVHLLRNA 144
           T    V +L ++
Sbjct: 145 TMGSAVKVLTSS 156



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 15/111 (13%)

Query: 84  LGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRN 143
           LG +I+GG E  + + +SK+     A++ G+  VGD VL  NG+  ++ +H + V +L+ 
Sbjct: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIK-VGDQVLAANGVRFDDISHSQAVEVLKG 280

Query: 144 AGDEVTITVEYLREAPAFLKL-------------PLGSPGPSSDHSSGASS 181
               + +T++     PA+ ++              L    P+S+ SS  SS
Sbjct: 281 Q-THIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSS 330


>gi|41281808 harmonin isoform b3 [Homo sapiens]
          Length = 899

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 34/93 (36%), Positives = 53/93 (56%), Gaps = 2/93 (2%)

Query: 67  QGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
           + R  + V L R    GLGLS++GG E    + IS + +   AD  G L VGD ++++NG
Sbjct: 81  RSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRING 139

Query: 127 IHVENATHEEVVHLLRNAGDEVTITVEYLREAP 159
             + + THEEV++L+R     V+I V ++   P
Sbjct: 140 YSISSCTHEEVINLIRTK-KTVSIKVRHIGLIP 171



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 1/62 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG SI  G      + IS +     + + G L +GD +++VNG+   N  H+E V++L+
Sbjct: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK 279

Query: 143 NA 144
           ++
Sbjct: 280 SS 281



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 26/90 (28%), Positives = 51/90 (56%), Gaps = 7/90 (7%)

Query: 68  GRNRRTVTLRRQPVGGLGLSIKGGSEHNV-PVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
           G++ R + ++++  G L L+++GG +  +  VV+S ++E  AA++ G +  GD ++ +NG
Sbjct: 750 GKDVRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 807

Query: 127 IHVENATHEEVVHLLRNA----GDEVTITV 152
             V + T  E    L+ A    GD + + V
Sbjct: 808 KIVTDYTLAEAEAALQKAWNQGGDWIDLVV 837


>gi|71480164 harmonin isoform a [Homo sapiens]
          Length = 552

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 34/93 (36%), Positives = 53/93 (56%), Gaps = 2/93 (2%)

Query: 67  QGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
           + R  + V L R    GLGLS++GG E    + IS + +   AD  G L VGD ++++NG
Sbjct: 81  RSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRING 139

Query: 127 IHVENATHEEVVHLLRNAGDEVTITVEYLREAP 159
             + + THEEV++L+R     V+I V ++   P
Sbjct: 140 YSISSCTHEEVINLIRTK-KTVSIKVRHIGLIP 171



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 1/62 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           GLG SI  G      + IS +     + + G L +GD +++VNG+   N  H+E V++L+
Sbjct: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK 279

Query: 143 NA 144
           ++
Sbjct: 280 SS 281



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 26/90 (28%), Positives = 51/90 (56%), Gaps = 7/90 (7%)

Query: 68  GRNRRTVTLRRQPVGGLGLSIKGGSEHNV-PVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
           G++ R + ++++  G L L+++GG +  +  VV+S ++E  AA++ G +  GD ++ +NG
Sbjct: 450 GKDVRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 507

Query: 127 IHVENATHEEVVHLLRNA----GDEVTITV 152
             V + T  E    L+ A    GD + + V
Sbjct: 508 KIVTDYTLAEAEAALQKAWNQGGDWIDLVV 537


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 8/117 (6%)

Query: 73  TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
           TV L+R   G LG++I G  E   P++IS + +   A++TG + +GD +L +N   ++  
Sbjct: 621 TVELKRYG-GPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGK 679

Query: 133 THEEVVHLLRNAGDEVTITVEYLREAPAF---LKLPLGSP----GPSSDHSSGASSP 182
              E +HLL+ AG+ VT+ ++   +A +     K P+ S     G   + SS A  P
Sbjct: 680 PLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKP 736



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 31/87 (35%), Positives = 50/87 (57%), Gaps = 6/87 (6%)

Query: 74  VTLRRQPVGGLGLSIKGG----SEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHV 129
           V L   PV G G+ ++G        + P +IS I  D  A++ G+L +GD V+ +NGI  
Sbjct: 421 VVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPT 480

Query: 130 ENATHEEVVHLLRNAG--DEVTITVEY 154
           E++T EE   LLR++    +VT+ +E+
Sbjct: 481 EDSTFEEASQLLRDSSITSKVTLEIEF 507



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 27/81 (33%), Positives = 47/81 (58%)

Query: 74  VTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENAT 133
           V L ++    LGL++ GG + +    +S + +   A ++  L VGD +  VNGI++    
Sbjct: 54  VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFR 113

Query: 134 HEEVVHLLRNAGDEVTITVEY 154
           H+E++ LL+N G+ V + VEY
Sbjct: 114 HDEIISLLKNVGERVVLEVEY 134



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 29/88 (32%), Positives = 45/88 (51%), Gaps = 5/88 (5%)

Query: 72  RTVTLRRQPVGG-LGLSIKGGSEHNV----PVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
           RTV +     G   G  I+GG+  +     PVVI+ +     AD+ G +  GD +L V+G
Sbjct: 149 RTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208

Query: 127 IHVENATHEEVVHLLRNAGDEVTITVEY 154
           I +   TH E + +L+  G E  + +EY
Sbjct: 209 IRLLGTTHAEAMSILKQCGQEAALLIEY 236



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 9/139 (6%)

Query: 74  VTLRRQPVGGLGLSIKGGSEHNVPV-VISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
           V + + P   LG+++      N  V VI KI     AD+ G L VGD +L ++G  +E  
Sbjct: 253 VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYC 312

Query: 133 THEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNG 192
           T  E    L N  D+V + +    +    LK P        DH++  SS    + +    
Sbjct: 313 TLAEATQFLANTTDQVKLEILPHHQTRLALKGP--------DHAALVSSSFSPTSMSAYS 364

Query: 193 NSSTTAPSSPSSPIAKDPR 211
            SS    + P S  +  PR
Sbjct: 365 LSSLNMGTLPRSLYSTSPR 383



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 23/71 (32%), Positives = 40/71 (56%), Gaps = 2/71 (2%)

Query: 84  LGLSIKGGSEHNV--PVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141
           LG++I   S      P+VIS I +   A +TG L +GD +L ++ I ++N + E+ V +L
Sbjct: 532 LGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQIL 591

Query: 142 RNAGDEVTITV 152
           +   D V + +
Sbjct: 592 QQCEDLVKLKI 602


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 26/78 (33%), Positives = 46/78 (58%), Gaps = 1/78 (1%)

Query: 73   TVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENA 132
            TV L R    G G S++GG E+N+ + + ++ ED  A++ G + +GD +L++NG   +N 
Sbjct: 1152 TVELERG-AKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1210

Query: 133  THEEVVHLLRNAGDEVTI 150
             H   + L++N G  V +
Sbjct: 1211 KHSRAIELIKNGGRRVRL 1228



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 2/99 (2%)

Query: 54   IQKQDVVCVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG 113
            +Q  DV    G ++G     V+   +P  G   +  G +   +P  I +I E   AD+ G
Sbjct: 994  VQPYDVEIRRGENEGFGFVIVSSVSRPEAGT--TFAGNACVAMPHKIGRIIEGSPADRCG 1051

Query: 114  MLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITV 152
             L VGD +L VNG  + N +H ++V+L++ AG+ VT+ +
Sbjct: 1052 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1090



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 1/96 (1%)

Query: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
           G G  I GG+E   P+ I  I    AAD  G L  GD ++ V+G  V   +H+ VV L++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909

Query: 143 NAGDEVTITVEYLREAP-AFLKLPLGSPGPSSDHSS 177
            A  +  + +   R+   A  K     P P+S H S
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS 945



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 5/134 (3%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATH 134
           T  R+   G G ++ GG E +  + I  +  D  A   G +  GD ++ VN   V   TH
Sbjct: 473 TKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTH 532

Query: 135 EEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNS 194
            +VV + ++     ++ +E  R  P    LP     P++   +  +  L    + +NG  
Sbjct: 533 AQVVKIFQSIPIGASVDLELCRGYP----LPFDPDDPNTSLVTSVAI-LDKEPIIVNGQE 587

Query: 195 STTAPSSPSSPIAK 208
           +  +P+S SS   K
Sbjct: 588 TYDSPASHSSKTGK 601



 Score = 37.4 bits (85), Expect = 0.035
 Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 75  TLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTG-----MLFVGDAVLQVNGIHV 129
           T++R P G LG+++ GG+EH     +  +   +AA   G      L  G+ +L+V G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 130 ENATHEEVVHLLRNAGDEVT 149
                 +V+ ++ +  + VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 39/145 (26%), Positives = 56/145 (38%), Gaps = 20/145 (13%)

Query: 118 GDAVLQVNGIHVENATHEEVVHLLRNA--GDEVTITVEYLREAPAFLKLPLGSPGPSSD- 174
           GD +++VN  +V+  TH +VV +L     G EVT+ V+     P   K P   P    D 
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ-RGGLPVPKKSPKSQPLERKDS 741

Query: 175 HSSGASSPLFDSGLHLNGNSSTT------------APSSPSSPIAKDPRYEKRWLDTLSV 222
            +S   S      LH    S +T            AP    S   K P   K W  + S+
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801

Query: 223 ----PLSMARISRYKAGTEKLRWNA 243
               P+S +  S    G  +   N+
Sbjct: 802 YENRPMSPSPASGLSKGEREREINS 826


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,506,861
Number of Sequences: 37866
Number of extensions: 999188
Number of successful extensions: 4023
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 3550
Number of HSP's gapped (non-prelim): 466
length of query: 539
length of database: 18,247,518
effective HSP length: 107
effective length of query: 432
effective length of database: 14,195,856
effective search space: 6132609792
effective search space used: 6132609792
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.