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Search of human proteins with 9506545
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9506545 delta-like 4 protein precursor [Homo sapiens]
(685 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 1501 0.0
gi|110735443 delta-like 1 [Homo sapiens] 707 0.0
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 479 e-135
gi|4557679 jagged 1 precursor [Homo sapiens] 474 e-133
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 465 e-131
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 318 1e-86
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 318 1e-86
gi|148833508 notch1 preproprotein [Homo sapiens] 261 2e-69
gi|24041035 notch 2 preproprotein [Homo sapiens] 258 2e-68
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 242 1e-63
gi|134244285 Notch homolog 3 [Homo sapiens] 239 5e-63
gi|55770876 notch4 preproprotein [Homo sapiens] 236 7e-62
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 232 1e-60
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 224 3e-58
gi|112420992 crumbs homolog 2 [Homo sapiens] 220 3e-57
gi|148886654 polydom [Homo sapiens] 217 3e-56
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 217 3e-56
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 217 3e-56
gi|74136023 delta-like 1 homolog [Homo sapiens] 216 7e-56
gi|122937283 6720455I24Rik homolog [Homo sapiens] 209 5e-54
gi|4759146 slit homolog 2 [Homo sapiens] 196 6e-50
gi|11321571 slit homolog 3 [Homo sapiens] 191 1e-48
gi|188528675 slit homolog 1 [Homo sapiens] 184 3e-46
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 160 4e-39
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 159 6e-39
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 154 3e-37
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 149 8e-36
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 149 1e-35
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 145 2e-34
gi|153946395 tenascin C precursor [Homo sapiens] 137 3e-32
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 1501 bits (3887), Expect = 0.0
Identities = 685/685 (100%), Positives = 685/685 (100%)
Query: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV 60
MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV
Sbjct: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV 60
Query: 61 CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE 120
CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE
Sbjct: 61 CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE 120
Query: 121 AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY 180
AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY
Sbjct: 121 AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY 180
Query: 181 GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL 240
GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL
Sbjct: 181 GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL 240
Query: 241 CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC 300
CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC
Sbjct: 241 CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC 300
Query: 301 SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE 360
SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE
Sbjct: 301 SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE 360
Query: 361 HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR 420
HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR
Sbjct: 361 HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR 420
Query: 421 GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480
GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS
Sbjct: 421 GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480
Query: 481 IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV 540
IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV
Sbjct: 481 IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV 540
Query: 541 LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL 600
LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL
Sbjct: 541 LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL 600
Query: 601 DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS 660
DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS
Sbjct: 601 DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS 660
Query: 661 PRDSMYQSVCLISEERNECVIATEV 685
PRDSMYQSVCLISEERNECVIATEV
Sbjct: 661 PRDSMYQSVCLISEERNECVIATEV 685
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 707 bits (1824), Expect = 0.0
Identities = 361/738 (48%), Positives = 460/738 (62%), Gaps = 74/738 (10%)
Query: 5 SRSASGWALL--LLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG-------CR 55
SR A A+L LL +W SGVF+L+LQEF+N++G+L + C G CR
Sbjct: 3 SRCALALAVLSALLCQVWS-----SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACR 57
Query: 56 TFFRVCLKHFQAVVSPGP-CTFGTVSTPVLGTNSFAVRDDSSGGGR-----NPLQLPFNF 109
TFFRVCLKH+QA VSP P CT+G+ TPVLG +SF++ D GGG NP++ PF F
Sbjct: 58 TFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPD---GGGADSAFSNPIRFPFGF 114
Query: 110 TWPGTFSLIIEAWHAPG-DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLR 168
TWPGTFSLIIEA H DDL E P+ LIS++A Q L VG+ W D +S T L+
Sbjct: 115 TWPGTFSLIIEALHTDSPDDLATEN--PERLISRLATQRHLTVGEEWSQDLHSSGRTDLK 172
Query: 169 YSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHE 228
YSYR +C ++YYG+ CS C+ R+D FGH+ C G C PGW G YC +PICL GC E
Sbjct: 173 YSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDE 232
Query: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYC 288
Q+G+C KP EC CR GWQGR C+ECI + GC HGTC PWQC C EGWGGLFC+QDLNYC
Sbjct: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYC 292
Query: 289 THHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC 348
THH PCKNGATC+N+GQ SYTC+CRPGYTG CEL + ECD +PC+NGGSC D E+ Y C
Sbjct: 293 THHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
Query: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
CPPG+YG CE S ++CAD PCFNGG C + G Y+C CP ++G NCEKK+D C+S
Sbjct: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG-GYSCRCPVGYSGFNCEKKIDYCSS 411
Query: 409 NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPA 468
+PC+NG +C++ G + +CRC+ GF+G +C+ +V DCA +PCA+GGTC D N CTCP
Sbjct: 412 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP 471
Query: 469 GFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV-GLPPS- 526
G++GR C + C +PC N ATC+ +VC C G+ G C+F + LPP
Sbjct: 472 GYTGRNCS--APVSRCEHAPCHNGATCHE--RGHRYVCECARGYGGPNCQFLLPELPPGP 527
Query: 527 ---------------FPWVAVSLGVGLAVLLVLLGMVAVAV-RQLRLRR------PDDGS 564
FPWVAV GV + VL++LLG AV V +LRL++ P G
Sbjct: 528 AVVDLTEKLEGQGGPFPWVAVCAGV-ILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGE 586
Query: 565 REAMNNLSDFQKD-----NLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAP 619
E MNNL++ Q++ ++I A Q+KNTN+K + D DK N K + +DYNL
Sbjct: 587 TETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADK-NGFKARYPAVDYNLVQ 645
Query: 620 GPLG-----------RGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS-PRDSMYQ 667
G R T S + G LR R + CS +D+ YQ
Sbjct: 646 DLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQ 705
Query: 668 SVCLISEERNECVIATEV 685
SV +ISEE++ECVIATEV
Sbjct: 706 SVYVISEEKDECVIATEV 723
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 479 bits (1232), Expect = e-135
Identities = 236/550 (42%), Positives = 302/550 (54%), Gaps = 38/550 (6%)
Query: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG------- 53
M A R LLLL+ALW Q A G F+LQL N G L SG C+
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 54 ------CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSF------AVRDDS----- 95
C T+ RVCLK +QA V+P GPC++G +TPVLG NSF A D +
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 96 SGGGRNP--LQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQ 153
+GG ++P + +PF F WP +F+LI+EAW D E L LI +++ G +
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEEL----LIERVSHAGMINPED 176
Query: 154 NWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWT 213
W + + L RV C +NYY C++ C+ RND FGHY C GN +C+ GW
Sbjct: 177 RWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM 236
Query: 214 GEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCD 273
G+ C++ +C GC+ +G C+ P EC C GWQGR C+EC+P+ GC HG+C PWQC C+
Sbjct: 237 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE 296
Query: 274 EGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
WGGL CD+DLNYC H PC NG TC N+ Y CTC GY+G +CE C SNPC
Sbjct: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
Query: 334 RNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPN 393
NGGSC + G+ C CP G+ G C CA +PC GG+C ++ G + C CP
Sbjct: 357 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG--FECICPEQ 414
Query: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
+ G+ C+ + C PC N C N C C PG+ G C ++V+DC R C HGG
Sbjct: 415 WVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQCQHGG 473
Query: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
TC DL NG C CP GF GR CE+ D CASSPC + C DL+ D F C+CP GF
Sbjct: 474 TCKDLVNGYQCVCPRGFGGRHCELER--DECASSPCHSGGLC-EDLA-DGFHCHCPQGFS 529
Query: 514 GSRCEFPVGL 523
G CE V L
Sbjct: 530 GPLCEVDVDL 539
Score = 218 bits (554), Expect = 2e-56
Identities = 136/426 (31%), Positives = 172/426 (40%), Gaps = 88/426 (20%)
Query: 171 YRVICSDNYYGDNCSRL---CKKR---NDHFGHYVCQPDG-NLSCLPGWTGEYCQQPI-- 221
YR C D Y G NC + C N H V P G C GW+G C I
Sbjct: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEV--PSGFECHCPSGWSGPTCALDIDE 388
Query: 222 CLSGCHEQNGYCSKPA---ECLCRPGWQGRLC----NECIPHNGCRHGTCST---PWQCT 271
C S G C EC+C W G C NEC +C + C
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
Query: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
C GW G+ C ++N C C++G TC + Y C C G+ G CELE EC S+
Sbjct: 449 CIPGWKGINCHINVNDC--RGQCQHGGTCKDL-VNGYQCVCPRGFGGRHCELERDECASS 505
Query: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFN------------------ 373
PC +GG C+D DG+HC CP G+ G CE C SPC N
Sbjct: 506 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
Query: 374 --------------GGSCRE----------------------------RNQGANYACECP 391
GG+CR G N++C C
Sbjct: 566 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 625
Query: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAH 451
FTG+ C + +D C PC NGG C++ + C C G+ G C+ + +DC +PC
Sbjct: 626 SGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 685
Query: 452 GGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYG 511
G C+DL N C C G+ G+ C R C + C N TCY S DTF C CP G
Sbjct: 686 RGRCYDLVNDFYCACDDGWKGKTCHSREF--QCDAYTCSNGGTCYD--SGDTFRCACPPG 741
Query: 512 FVGSRC 517
+ GS C
Sbjct: 742 WKGSTC 747
Score = 203 bits (517), Expect = 4e-52
Identities = 125/399 (31%), Positives = 180/399 (45%), Gaps = 60/399 (15%)
Query: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQP--DG-NLSCLPGWTGEYCQQPI--- 221
Y+ +C + G +C C H G +C+ DG + C G++G C+ +
Sbjct: 482 YQCVCPRGFGGRHCELERDECASSPCHSGG-LCEDLADGFHCHCPQGFSGPLCEVDVDLC 540
Query: 222 ----CLSG--CHEQNGYCSKPAECLCRPGWQGRLCN---ECIPHNGCR------------ 260
C +G C+ G C C + G+ C+ E P CR
Sbjct: 541 EPSPCRNGARCYNLEG----DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 596
Query: 261 ------------HGTC-STP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
HG C S P + C CD G+ G +C ++++ C PC+NG TC +
Sbjct: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQ-PCRNGGTCIDEV 655
Query: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
++ C C G+ G C+ ++C +PC + G C D + ++C C G+ G C
Sbjct: 656 D-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 714
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
C C NGG+C + G + C CPP + GS C K C NPC NGG C+ G S
Sbjct: 715 QCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 772
Query: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
C CR G+ G C + +DC PC +GG C D N C C GF+G C R +ID
Sbjct: 773 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC--RINIDE 830
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
C SSPC ATC +++ + C+CP G G RC+ +G
Sbjct: 831 CQSSPCAYGATCVDEING--YRCSCPPGRAGPRCQEVIG 867
Score = 189 bits (481), Expect = 6e-48
Identities = 118/354 (33%), Positives = 160/354 (45%), Gaps = 30/354 (8%)
Query: 167 LRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDG-NLSCLPGWTGEYCQQPICLSG 225
L Y C D++ G NCS R G DG PG G SG
Sbjct: 554 LEGDYYCACPDDFGGKNCS---VPREPCPGGACRVIDGCGSDAGPGMPGT------AASG 604
Query: 226 CHEQNGYC-SKPA---ECLCRPGWQGRLCNECIPH---NGCRHG-TCSTP---WQCTCDE 274
+G C S+P C+C G+ G C+E I CR+G TC ++C C
Sbjct: 605 VCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 664
Query: 275 GWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCR 334
GW G CD + N C PC + C + Y C C G+ G C +CD+ C
Sbjct: 665 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYTCS 722
Query: 335 NGGSCKDQEDGYHCLCPPGYYGLHCEHS-TLSCADSPCFNGGSCRERNQGANYACECPPN 393
NGG+C D D + C CPPG+ G C + SC +PC NGG+C GA+++C C
Sbjct: 723 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV--GSGASFSCICRDG 780
Query: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
+ G C + C PC NGG C++ C C PGF G C +++ +C +PCA+G
Sbjct: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
Query: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCN 507
TC D NG C+CP G +G RC+ C++R T + S+ CN
Sbjct: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGF----GRSCWSRGTPFPHGSSWVEDCN 890
Score = 178 bits (452), Expect = 1e-44
Identities = 113/403 (28%), Positives = 160/403 (39%), Gaps = 57/403 (14%)
Query: 171 YRVICSDNYYGDNCS---RLCKKRNDHFGHYVCQPDG-NLSCLPGWTGEYCQ--QPICLS 224
Y C + G NC C+ + H G +G C G+ G +C+ + C S
Sbjct: 445 YYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 504
Query: 225 GCHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIP---HNGCRHGTCSTPWQCTCDE 274
G C A+ C C G+ G LC C P NG R + C C +
Sbjct: 505 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564
Query: 275 GWGGLFCDQDLNYCTHHSPCKNGAT----------------------------CSNSGQR 306
+GG C PC GA C +
Sbjct: 565 DFGGKNCS------VPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
Query: 307 SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
+++C C G+TG C + +C PCRNGG+C D+ D + C CP G+ G C+ + C
Sbjct: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426
PC + G C + ++ C C + G C + +C + C+NGG C + G + C
Sbjct: 679 LPDPCHSRGRCYDLVN--DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736
Query: 427 RCRPGFTGTYCELHV-SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACA 485
C PG+ G+ C + S C NPC +GGTC C C G+ GR C T+ C
Sbjct: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN--DCN 794
Query: 486 SSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
PC+N C ++ F C C GF G C + S P
Sbjct: 795 PLPCYNGGICVDGVNW--FRCECAPGFAGPDCRINIDECQSSP 835
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/184 (30%), Positives = 79/184 (42%), Gaps = 20/184 (10%)
Query: 350 CPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSN 409
C G+ G C+ + C G C + C C + G C D C
Sbjct: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC----DECVPY 279
Query: 410 PCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC-ARNPCAHGGTCHDLE-NGLMCTCP 467
P G C+ C C + G C+ ++ C + +PC +GGTC + E + CTCP
Sbjct: 280 PGCVHGSCVEPW---QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
Query: 468 AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSF 527
G+SGR CE + AC S+PC N +C+ S F C+CP G+ G C + S
Sbjct: 337 DGYSGRNCE--KAEHACTSNPCANGGSCHEVPSG--FECHCPSGWSGPTCALDIDECASN 392
Query: 528 PWVA 531
P A
Sbjct: 393 PCAA 396
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 474 bits (1219), Expect = e-133
Identities = 213/522 (40%), Positives = 302/522 (57%), Gaps = 26/522 (4%)
Query: 13 LLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPC----EPG--------CRTFFRV 60
L LL AL + SG F+L++ N G L +G C PG C T+F+V
Sbjct: 18 LALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKV 77
Query: 61 CLKHFQA-VVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLII 119
CLK +Q+ V + GPC+FG+ STPV+G N+F ++ S G RN + LPF+F WP +++L++
Sbjct: 78 CLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKA-SRGNDRNRIVLPFSFAWPRSYTLLV 136
Query: 120 EAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNY 179
EAW + D ++P D++I K + G + + W +Q + + Y RV C D Y
Sbjct: 137 EAWDSSNDTVQP-----DSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYY 191
Query: 180 YGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAEC 239
YG C++ C+ R+D FGHY C +GN +C+ GW G C + IC GC ++G C P +C
Sbjct: 192 YGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDC 251
Query: 240 LCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGAT 299
C+ GWQG C++CIPH GC HG C+ PWQC C+ WGG CD+DLNYC H PC NG T
Sbjct: 252 RCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGT 311
Query: 300 CSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHC 359
CSN+G Y C+C GY+G +CE+ C S+PC N GSCK+ G+ C C PG+ G C
Sbjct: 312 CSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTC 371
Query: 360 EHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLN 419
+ C+ + C +GG+C++ G + C CPP +TG C+ + C + PC N C N
Sbjct: 372 STNIDDCSPNNCSHGGTCQDLVNG--FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKN 429
Query: 420 RGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT 479
S C C PG+ G C+++++DC C + +C DL NG C CP G++G CE
Sbjct: 430 LIASYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCE--R 486
Query: 480 SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
ID CAS+PC N C ++ + F C CP GF G+ C+ +
Sbjct: 487 DIDECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDI 526
Score = 233 bits (595), Expect = 3e-61
Identities = 128/388 (32%), Positives = 179/388 (46%), Gaps = 54/388 (13%)
Query: 175 CSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGN---LSCLPGWTGEYCQQPI------- 221
CS + G CS C N G CQ N C P WTG+ CQ
Sbjct: 362 CSPGWTGPTCSTNIDDCSPNNCSHGG-TCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP 420
Query: 222 CLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPH--NGCRHGTCSTPWQCTCDEG 275
C++ +N S +CL PGW G+ C N+C+ N ++C C G
Sbjct: 421 CVNAKSCKNLIASYYCDCL--PGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPG 478
Query: 276 WGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRN 335
+ G C++D++ C + PC NG C N R + C C G++G C+L++ C+ NPC+N
Sbjct: 479 YAGDHCERDIDECASN-PCLNGGHCQNEINR-FQCLCPTGFSGNLCQLDIDYCEPNPCQN 536
Query: 336 GGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCR----------------- 378
G C ++ Y C CP Y G +C H C +PC SC
Sbjct: 537 GAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISS 596
Query: 379 ---------ERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCR 429
+ G + C+C FTG+ C + ++ C SNPC NGG C++ S C C
Sbjct: 597 NVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICS 656
Query: 430 PGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPC 489
G+ G YCE +++DC++NPC +GGTC DL N C C G+ G+ C R S C + C
Sbjct: 657 DGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS--QCDEATC 714
Query: 490 FNRATCYTDLSTDTFVCNCPYGFVGSRC 517
N TCY + D F C CP G+ G+ C
Sbjct: 715 NNGGTCYDE--GDAFKCMCPGGWEGTTC 740
Score = 227 bits (579), Expect = 2e-59
Identities = 127/401 (31%), Positives = 187/401 (46%), Gaps = 56/401 (13%)
Query: 171 YRVICSDNYYGDNCSRLCKK--RNDHFGHYVCQPDGN---LSCLPGWTGEYCQQPI--CL 223
YR IC Y GD+C R + N CQ + N C G++G CQ I C
Sbjct: 471 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE 530
Query: 224 SGCHEQNGYCSKPAE---CLCRPGWQGRLC------------------------------ 250
+ C A C C ++G+ C
Sbjct: 531 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG 590
Query: 251 ------NECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
N C PH C+ + + C C++G+ G +C +++N C +PC+NG TC + G
Sbjct: 591 VRYISSNVCGPHGKCKSQS-GGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-G 647
Query: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
SY C C G+ G CE +++C NPC NGG+C+D + ++C C G+ G C
Sbjct: 648 VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDS 707
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
C ++ C NGG+C + +G + C CP + G+ C + C NPC NGG C+ G S
Sbjct: 708 QCDEATCNNGGTCYD--EGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGES 765
Query: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
C C+ G+ G C + +DC+ +PC + GTC D +N C C GF+G C R +I+
Sbjct: 766 FTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC--RININE 823
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524
C SSPC ATC +++ + C CP G G++C+ G P
Sbjct: 824 CQSSPCAFGATCVDEING--YRCVCPPGHSGAKCQEVSGRP 862
Score = 211 bits (538), Expect = 1e-54
Identities = 127/411 (30%), Positives = 184/411 (44%), Gaps = 67/411 (16%)
Query: 170 SYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLS---------CLPGWTGEYCQQP 220
SY C + G NC ND G CQ D + C PG+ G++C++
Sbjct: 433 SYYCDCLPGWMGQNCDI---NINDCLGQ--CQNDASCRDLVNGYRCICPPGYAGDHCERD 487
Query: 221 I-------CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH---NGCRHGT-C---ST 266
I CL+G H QN +CLC G+ G LC I + N C++G C ++
Sbjct: 488 IDECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS 545
Query: 267 PWQCTCDEGWGGLFCDQDLNYCTHHSPCK----------------------------NGA 298
+ C C E + G C ++C +PC+ +G
Sbjct: 546 DYFCKCPEDYEGKNCSHLKDHC-RTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGK 604
Query: 299 TCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLH 358
S SG + +TC C G+TG C +++C+SNPCRNGG+C D + Y C+C G+ G +
Sbjct: 605 CKSQSGGK-FTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAY 663
Query: 359 CEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418
CE + C+ +PC NGG+CR+ ++ C+C + G C + +C C NGG C
Sbjct: 664 CETNINDCSQNPCHNGGTCRDLVN--DFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY 721
Query: 419 NRGPSRMCRCRPGFTGTYCEL-HVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV 477
+ G + C C G+ GT C + S C NPC +GGTC C C G+ G C
Sbjct: 722 DEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
Query: 478 RTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
T+ C+ PC+N TC + + C C GF G C + S P
Sbjct: 782 NTN--DCSPHPCYNSGTCVD--GDNWYRCECAPGFAGPDCRININECQSSP 828
Score = 207 bits (528), Expect = 2e-53
Identities = 116/357 (32%), Positives = 164/357 (45%), Gaps = 39/357 (10%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGE-------YCQQPIC--LSG 225
C ++Y G NCS L DH C+ SC Y +C
Sbjct: 551 CPEDYEGKNCSHL----KDHCRTTPCEVID--SCTVAMASNDTPEGVRYISSNVCGPHGK 604
Query: 226 CHEQNGYCSKPAECLCRPGWQGRLCNECI---PHNGCRHG-TCS---TPWQCTCDEGWGG 278
C Q+G C C G+ G C+E I N CR+G TC ++C C +GW G
Sbjct: 605 CKSQSG---GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661
Query: 279 LFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGS 338
+C+ ++N C+ + PC NG TC + Y C C+ G+ G C S+CD C NGG+
Sbjct: 662 AYCETNINDCSQN-PCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNNGGT 719
Query: 339 CKDQEDGYHCLCPPGYYGLHCEHS-TLSCADSPCFNGGSCRERNQGANYACECPPNFTGS 397
C D+ D + C+CP G+ G C + SC +PC NGG+C G ++ C C + G
Sbjct: 720 CYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN--GESFTCVCKEGWEGP 777
Query: 398 NCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHD 457
C + + C+ +PC N G C++ C C PGF G C +++++C +PCA G TC D
Sbjct: 778 ICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVD 837
Query: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTD---LSTDTFVCNCPYG 511
NG C CP G SG +C+ + PC + D D C C G
Sbjct: 838 EINGYRCVCPPGHSGAKCQ------EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNG 888
Score = 147 bits (370), Expect = 4e-35
Identities = 94/296 (31%), Positives = 127/296 (42%), Gaps = 57/296 (19%)
Query: 170 SYRVICSDNYYGDNCS---RLCKKRNDHFGHYVCQP---DGNLSCLPGWTGEYC--QQPI 221
SY+ ICSD + G C C + H G C+ D C GW G+ C +
Sbjct: 650 SYKCICSDGWEGAYCETNINDCSQNPCHNGG-TCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
Query: 222 CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCN-----ECIP---HNGCRHGTC---STP 267
C G C + C+C GW+G CN C+P HNG GTC
Sbjct: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNG---GTCVVNGES 765
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
+ C C EGW G C Q+ N C+ H PC N TC + G Y C C PG+ G DC + ++E
Sbjct: 766 FTCVCKEGWEGPICAQNTNDCSPH-PCYNSGTCVD-GDNWYRCECAPGFAGPDCRININE 823
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST------------------LSCADS 369
C S+PC G +C D+ +GY C+CPPG+ G C+ + C
Sbjct: 824 CQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTC 883
Query: 370 PCFNGGSCRERNQGANYAC-------ECPPNFTGSNCEKKV-DRCTSNPCANGGQC 417
C NG + C ECP +G +C + D+C +PC G+C
Sbjct: 884 QCLNGRIACSKVWCGPRPCLLHKGHSECP---SGQSCIPILDDQCFVHPCTGVGEC 936
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 465 bits (1197), Expect = e-131
Identities = 231/547 (42%), Positives = 298/547 (54%), Gaps = 38/547 (6%)
Query: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG------- 53
M A R LLLL+ALW Q A G F+LQL N G L SG C+
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 54 ------CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSF------AVRDDS----- 95
C T+ RVCLK +QA V+P GPC++G +TPVLG NSF A D +
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 96 SGGGRNP--LQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQ 153
+GG ++P + +PF F WP +F+LI+EAW D E L LI +++ G +
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEEL----LIERVSHAGMINPED 176
Query: 154 NWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWT 213
W + + L RV C +NYY C++ C+ RND FGHY C GN +C+ GW
Sbjct: 177 RWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM 236
Query: 214 GEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCD 273
G+ C++ +C GC+ +G C+ P EC C GWQGR C+EC+P+ GC HG+C PWQC C+
Sbjct: 237 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE 296
Query: 274 EGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
WGGL CD+DLNYC H PC NG TC N+ Y CTC GY+G +CE C SNPC
Sbjct: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
Query: 334 RNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPN 393
NGGSC + G+ C CP G+ G C CA +PC GG+C ++ G + C CP
Sbjct: 357 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG--FECICPEQ 414
Query: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
+ G+ C+ V+ C C +GG C + C C GF G +CEL +CA +PC GG
Sbjct: 415 WVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGG 473
Query: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
C DL +G C CP GFSG CEV +D C SPC N A CY +L D + C CP F
Sbjct: 474 LCEDLADGFHCHCPQGFSGPLCEV--DVDLCEPSPCRNGARCY-NLEGD-YYCACPDDFG 529
Query: 514 GSRCEFP 520
G C P
Sbjct: 530 GKNCSVP 536
Score = 218 bits (554), Expect = 2e-56
Identities = 133/426 (31%), Positives = 176/426 (41%), Gaps = 94/426 (22%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFG-HYVCQPDGNL----------SCLPGWTGEYCQQP--I 221
C N+ G LC K ++ G H+ C G +C G++G C++
Sbjct: 295 CETNWGG----LLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
Query: 222 CLSGCHEQNGYCSKPA---ECLCRPGWQGRLC----NECIPHNGCRHGTCSTP---WQCT 271
C S G C + EC C GW G C +EC + GTC ++C
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
Query: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
C E W G C D+N C C++G TC + Y C C G+ G CELE EC S+
Sbjct: 411 CPEQWVGATCQLDVNDC--RGQCQHGGTCKDL-VNGYQCVCPRGFGGRHCELERDECASS 467
Query: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFN------------------ 373
PC +GG C+D DG+HC CP G+ G CE C SPC N
Sbjct: 468 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527
Query: 374 --------------GGSCRE----------------------------RNQGANYACECP 391
GG+CR G N++C C
Sbjct: 528 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 587
Query: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAH 451
FTG+ C + +D C PC NGG C++ + C C G+ G C+ + +DC +PC
Sbjct: 588 SGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 647
Query: 452 GGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYG 511
G C+DL N C C G+ G+ C R C + C N TCY S DTF C CP G
Sbjct: 648 RGRCYDLVNDFYCACDDGWKGKTCHSREF--QCDAYTCSNGGTCYD--SGDTFRCACPPG 703
Query: 512 FVGSRC 517
+ GS C
Sbjct: 704 WKGSTC 709
Score = 203 bits (517), Expect = 4e-52
Identities = 125/399 (31%), Positives = 180/399 (45%), Gaps = 60/399 (15%)
Query: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQP--DG-NLSCLPGWTGEYCQQPI--- 221
Y+ +C + G +C C H G +C+ DG + C G++G C+ +
Sbjct: 444 YQCVCPRGFGGRHCELERDECASSPCHSGG-LCEDLADGFHCHCPQGFSGPLCEVDVDLC 502
Query: 222 ----CLSG--CHEQNGYCSKPAECLCRPGWQGRLCN---ECIPHNGCR------------ 260
C +G C+ G C C + G+ C+ E P CR
Sbjct: 503 EPSPCRNGARCYNLEG----DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 558
Query: 261 ------------HGTC-STP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
HG C S P + C CD G+ G +C ++++ C PC+NG TC +
Sbjct: 559 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQ-PCRNGGTCIDEV 617
Query: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
++ C C G+ G C+ ++C +PC + G C D + ++C C G+ G C
Sbjct: 618 D-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 676
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
C C NGG+C + G + C CPP + GS C K C NPC NGG C+ G S
Sbjct: 677 QCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 734
Query: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
C CR G+ G C + +DC PC +GG C D N C C GF+G C R +ID
Sbjct: 735 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC--RINIDE 792
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
C SSPC ATC +++ + C+CP G G RC+ +G
Sbjct: 793 CQSSPCAYGATCVDEING--YRCSCPPGRAGPRCQEVIG 829
Score = 189 bits (481), Expect = 6e-48
Identities = 118/354 (33%), Positives = 160/354 (45%), Gaps = 30/354 (8%)
Query: 167 LRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDG-NLSCLPGWTGEYCQQPICLSG 225
L Y C D++ G NCS R G DG PG G SG
Sbjct: 516 LEGDYYCACPDDFGGKNCS---VPREPCPGGACRVIDGCGSDAGPGMPGT------AASG 566
Query: 226 CHEQNGYC-SKPA---ECLCRPGWQGRLCNECIPH---NGCRHG-TCSTP---WQCTCDE 274
+G C S+P C+C G+ G C+E I CR+G TC ++C C
Sbjct: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 626
Query: 275 GWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCR 334
GW G CD + N C PC + C + Y C C G+ G C +CD+ C
Sbjct: 627 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYTCS 684
Query: 335 NGGSCKDQEDGYHCLCPPGYYGLHCEHS-TLSCADSPCFNGGSCRERNQGANYACECPPN 393
NGG+C D D + C CPPG+ G C + SC +PC NGG+C GA+++C C
Sbjct: 685 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV--GSGASFSCICRDG 742
Query: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
+ G C + C PC NGG C++ C C PGF G C +++ +C +PCA+G
Sbjct: 743 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 802
Query: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCN 507
TC D NG C+CP G +G RC+ C++R T + S+ CN
Sbjct: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGF----GRSCWSRGTPFPHGSSWVEDCN 852
Score = 181 bits (458), Expect = 3e-45
Identities = 112/403 (27%), Positives = 161/403 (39%), Gaps = 57/403 (14%)
Query: 171 YRVICSDNYYGDNCS---RLCKKRNDHFGHYVCQPDG-NLSCLPGWTGEYCQ--QPICLS 224
+ IC + + G C C+ + H G +G C G+ G +C+ + C S
Sbjct: 407 FECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466
Query: 225 GCHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIP---HNGCRHGTCSTPWQCTCDE 274
G C A+ C C G+ G LC C P NG R + C C +
Sbjct: 467 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 526
Query: 275 GWGGLFCDQDLNYCTHHSPCKNGAT----------------------------CSNSGQR 306
+GG C PC GA C +
Sbjct: 527 DFGGKNCS------VPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 580
Query: 307 SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
+++C C G+TG C + +C PCRNGG+C D+ D + C CP G+ G C+ + C
Sbjct: 581 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 640
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426
PC + G C + ++ C C + G C + +C + C+NGG C + G + C
Sbjct: 641 LPDPCHSRGRCYDLVN--DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 698
Query: 427 RCRPGFTGTYCELHV-SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACA 485
C PG+ G+ C + S C NPC +GGTC C C G+ GR C T+ C
Sbjct: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN--DCN 756
Query: 486 SSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
PC+N C ++ F C C GF G C + S P
Sbjct: 757 PLPCYNGGICVDGVNW--FRCECAPGFAGPDCRINIDECQSSP 797
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/184 (30%), Positives = 79/184 (42%), Gaps = 20/184 (10%)
Query: 350 CPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSN 409
C G+ G C+ + C G C + C C + G C D C
Sbjct: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC----DECVPY 279
Query: 410 PCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC-ARNPCAHGGTCHDLE-NGLMCTCP 467
P G C+ C C + G C+ ++ C + +PC +GGTC + E + CTCP
Sbjct: 280 PGCVHGSCVEPW---QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
Query: 468 AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSF 527
G+SGR CE + AC S+PC N +C+ S F C+CP G+ G C + S
Sbjct: 337 DGYSGRNCE--KAEHACTSNPCANGGSCHEVPSG--FECHCPSGWSGPTCALDIDECASN 392
Query: 528 PWVA 531
P A
Sbjct: 393 PCAA 396
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 318 bits (814), Expect = 1e-86
Identities = 215/581 (37%), Positives = 263/581 (45%), Gaps = 96/581 (16%)
Query: 13 LLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG--CRTFFRVCLKH-FQAVV 69
+L L+ L Q R AG VF+LQ+ F G A PC CR FFRVCLK
Sbjct: 15 ILALIFLPQTRPAG--VFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEA 72
Query: 70 SPGPCTFGTVST---PVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAP- 125
+ PC G + PV A D LQ+PF WPGTFS IIE W
Sbjct: 73 AESPCALGAALSARGPVYTEQPGAPAPDLPLPD-GLLQVPFRDAWPGTFSFIIETWREEL 131
Query: 126 GDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCS 185
GD + P +L++++A + LA G W D Q + LR+SYR C G C+
Sbjct: 132 GDQIGG---PAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACT 188
Query: 186 RLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGW 245
RLC+ R+ C PG L C C P +CR G
Sbjct: 189 RLCRPRS-----------APSRCGPG-----------LRPCAPLEDECEAPL--VCRAG- 223
Query: 246 QGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ 305
C P HG C P +C C EGW G C P + S G
Sbjct: 224 -------CSPE----HGFCEQPGECRCLEGWTGPLCTV---------PVSTSSCLSPRGP 263
Query: 306 RSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLS 365
S T C G CD NPC NGGSC + + C CP G+YGL CE S ++
Sbjct: 264 SSATTGCLVPGPG--------PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVT 315
Query: 366 CADSPCFNGGSC-RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSR 424
CAD PCFNGG C + + Y C CPP F GSNCEK+VDRC+ PC NGG CL+ G +
Sbjct: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHAL 375
Query: 425 MCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
CRCR GF G CE + DCA CA+GGTC + C+C GF GR C R D C
Sbjct: 376 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA--DPC 433
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV-------------GLPPSFP--- 528
A+ PC + CY S VC C G++G+RCEFPV GL P P
Sbjct: 434 AARPCAHGGRCYAHFS--GLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRY 491
Query: 529 WVAVSLGVGLAVLLVLLGMVAVAVRQLRLRR----PDDGSR 565
+ +LG LLV G+ A+ + +RR D GSR
Sbjct: 492 LLPPALG-----LLVAAGVAGAALLLVHVRRRGHSQDAGSR 527
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 318 bits (814), Expect = 1e-86
Identities = 215/581 (37%), Positives = 263/581 (45%), Gaps = 96/581 (16%)
Query: 13 LLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG--CRTFFRVCLKH-FQAVV 69
+L L+ L Q R AG VF+LQ+ F G A PC CR FFRVCLK
Sbjct: 15 ILALIFLPQTRPAG--VFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEA 72
Query: 70 SPGPCTFGTVST---PVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAP- 125
+ PC G + PV A D LQ+PF WPGTFS IIE W
Sbjct: 73 AESPCALGAALSARGPVYTEQPGAPAPDLPLPD-GLLQVPFRDAWPGTFSFIIETWREEL 131
Query: 126 GDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCS 185
GD + P +L++++A + LA G W D Q + LR+SYR C G C+
Sbjct: 132 GDQIGG---PAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACT 188
Query: 186 RLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGW 245
RLC+ R+ C PG L C C P +CR G
Sbjct: 189 RLCRPRS-----------APSRCGPG-----------LRPCAPLEDECEAPL--VCRAG- 223
Query: 246 QGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ 305
C P HG C P +C C EGW G C P + S G
Sbjct: 224 -------CSPE----HGFCEQPGECRCLEGWTGPLCTV---------PVSTSSCLSPRGP 263
Query: 306 RSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLS 365
S T C G CD NPC NGGSC + + C CP G+YGL CE S ++
Sbjct: 264 SSATTGCLVPGPG--------PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVT 315
Query: 366 CADSPCFNGGSC-RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSR 424
CAD PCFNGG C + + Y C CPP F GSNCEK+VDRC+ PC NGG CL+ G +
Sbjct: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHAL 375
Query: 425 MCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
CRCR GF G CE + DCA CA+GGTC + C+C GF GR C R D C
Sbjct: 376 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA--DPC 433
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV-------------GLPPSFP--- 528
A+ PC + CY S VC C G++G+RCEFPV GL P P
Sbjct: 434 AARPCAHGGRCYAHFS--GLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRY 491
Query: 529 WVAVSLGVGLAVLLVLLGMVAVAVRQLRLRR----PDDGSR 565
+ +LG LLV G+ A+ + +RR D GSR
Sbjct: 492 LLPPALG-----LLVAAGVAGAALLLVHVRRRGHSQDAGSR 527
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 261 bits (666), Expect = 2e-69
Identities = 144/382 (37%), Positives = 184/382 (48%), Gaps = 38/382 (9%)
Query: 171 YRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQ------QPICLS 224
Y C Y G +C D C G +C G G C+ P CLS
Sbjct: 662 YECACEPGYTGS----MCNINIDECAGNPCHNGG--TCEDGINGFTCRCPEGYHDPTCLS 715
Query: 225 GCHEQN------GYCSKPA---ECLCRPGWQGRLC----NECIPHNGCRHGTC---STPW 268
+E N G C +C C PGW G C NEC + GTC ++ +
Sbjct: 716 EVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGY 775
Query: 269 QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC 328
CTC EG+ G C ++N C + PC N TC + Y C C YTG CE+ L+ C
Sbjct: 776 VCTCREGFSGPNCQTNINECASN-PCLNQGTCIDD-VAGYKCNCLLPYTGATCEVVLAPC 833
Query: 329 DSNPCRNGGSCKDQED--GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY 386
+PCRNGG C+ ED + C+CP G+ G CE C SPC +G SC+ + G Y
Sbjct: 834 APSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGG--Y 891
Query: 387 ACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCAR 446
C C ++G NCE +D C NPC NGG C + + C C PGF GT+CE +++CA
Sbjct: 892 RCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECAS 951
Query: 447 NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVC 506
+PC +G C D + CTCPAGFSG CE T C S CFN TC + ++F C
Sbjct: 952 DPCRNGANCTDCVDSYTCTCPAGFSGIHCENNT--PDCTESSCFNGGTCVDGI--NSFTC 1007
Query: 507 NCPYGFVGSRCEFPVGLPPSFP 528
CP GF GS C+ V S P
Sbjct: 1008 LCPPGFTGSYCQHDVNECDSQP 1029
Score = 251 bits (641), Expect = 2e-66
Identities = 143/423 (33%), Positives = 200/423 (47%), Gaps = 86/423 (20%)
Query: 170 SYRVICSDNYYGDNC--------SRLCKKRN---DHFGHYVCQPDGNLSCLPGWTGEYCQ 218
S+ C Y G C S C+ D G + C C+PG+ G +C+
Sbjct: 435 SFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQC------ICMPGYEGVHCE 488
Query: 219 QPI--CLSGCHEQNGYCSKPA---ECLCRPGWQGRLC----NECIP---HNGCRHGTCST 266
C S NG C +C C G+ G LC +EC NG +
Sbjct: 489 VNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPN 548
Query: 267 PWQCTCDEGWGGLFCDQDLNYCT----HHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE 322
+ C C EG+ G C+ D++ C H+ CK+G ++TC CRPGYTG CE
Sbjct: 549 TYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVA-------TFTCLCRPGYTGHHCE 601
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
++EC S PCR+GG+C+D+++ Y C C G G +CE + CA SPC + G+C ++
Sbjct: 602 TNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPC-DSGTCLDKID 660
Query: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQC------------------------- 417
G Y C C P +TGS C +D C NPC NGG C
Sbjct: 661 G--YECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVN 718
Query: 418 -LNRGP-----------SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCT 465
N P C C PG++GT C+++ ++C NPC +GGTC D+ +G +CT
Sbjct: 719 ECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778
Query: 466 CPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPP 525
C GFSG C+ T+I+ CAS+PC N+ TC D++ + CNC + G+ CE V L P
Sbjct: 779 CREGFSGPNCQ--TNINECASNPCLNQGTCIDDVA--GYKCNCLLPYTGATCE--VVLAP 832
Query: 526 SFP 528
P
Sbjct: 833 CAP 835
Score = 250 bits (639), Expect = 3e-66
Identities = 136/375 (36%), Positives = 188/375 (50%), Gaps = 73/375 (19%)
Query: 205 NLSCLPGWTGEYCQQPI-------CLSG--CHEQ--NGYCSKPAECLCRPGWQGRLC--N 251
N C+ GWTGE C + I C G CH++ + YC C G G LC N
Sbjct: 320 NCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE------CPHGRTGLLCHLN 373
Query: 252 ECIPHNGCRHGT-CST-----PWQCTCDEGWGGLFCDQDLNYCT-HHSPCKNGATCSNSG 304
+ N C G+ C T CTC G+ G C QD++ C+ +PC++ C N+
Sbjct: 374 DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINT- 432
Query: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
S+ C C GYTG CE++++EC SNPC+N +C DQ + C+C PGY G+HCE +T
Sbjct: 433 LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTD 492
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSR 424
CA SPC + G C ++ + CECP FTG C+ VD C S PC NG +CL+ GP+
Sbjct: 493 ECASSPCLHNGRCLDKIN--EFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLD-GPNT 549
Query: 425 M--------------------------------------CRCRPGFTGTYCELHVSDCAR 446
C CRPG+TG +CE ++++C+
Sbjct: 550 YTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSS 609
Query: 447 NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVC 506
PC HGGTC D +N +C C G +G CE+ ++D CASSPC + TC + D + C
Sbjct: 610 QPCRHGGTCQDRDNAYLCFCLKGTTGPNCEI--NLDDCASSPC-DSGTCLDKI--DGYEC 664
Query: 507 NCPYGFVGSRCEFPV 521
C G+ GS C +
Sbjct: 665 ACEPGYTGSMCNINI 679
Score = 248 bits (634), Expect = 1e-65
Identities = 134/375 (35%), Positives = 179/375 (47%), Gaps = 39/375 (10%)
Query: 171 YRVICSDNYYGDNC---SRLCKKR--------NDHFGHYVCQPDGNLSCLPGWTGEYCQQ 219
Y+ C + G NC + C+ D YVC +C G++G CQ
Sbjct: 737 YKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVC------TCREGFSGPNCQT 790
Query: 220 PI--CLSGCHEQNGYCSKPA---ECLCRPGWQGRLCN----ECIP---HNG--CRHGTCS 265
I C S G C +C C + G C C P NG CR
Sbjct: 791 NINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 266 TPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL 325
+ C C GW G C+ D+N C SPC++GA+C N+ Y C C+ GY+G +CE ++
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINECVL-SPCRHGASCQNT-HGGYRCHCQAGYSGRNCETDI 908
Query: 326 SECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGAN 385
+C NPC NGGSC D + C C PG+ G CE CA PC NG +C + +
Sbjct: 909 DDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVD--S 966
Query: 386 YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA 445
Y C CP F+G +CE CT + C NGG C++ S C C PGFTG+YC+ V++C
Sbjct: 967 YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECD 1026
Query: 446 RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFV 505
PC HGGTC D CTCP G++G C+ + C SSPC N C+ + +
Sbjct: 1027 SQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQ--NLVHWCDSSPCKNGGKCWQ--THTQYR 1082
Query: 506 CNCPYGFVGSRCEFP 520
C CP G+ G C+ P
Sbjct: 1083 CECPSGWTGLYCDVP 1097
Score = 248 bits (632), Expect = 2e-65
Identities = 140/387 (36%), Positives = 191/387 (49%), Gaps = 51/387 (13%)
Query: 170 SYRVICSDNYYGDNCS--------RLCKK----RNDHFGHYVCQPDGNLSCLPGWTGEYC 217
S+ +C + G C C+ +N H G Y C C G++G C
Sbjct: 852 SFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTH-GGYRCH------CQAGYSGRNC 904
Query: 218 QQPI--CLSGCHEQNGYCS---KPAECLCRPGWQGRLC----NECIPHNGCRHGT----C 264
+ I C G C+ A C C PG++G C NEC + CR+G C
Sbjct: 905 ETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECAS-DPCRNGANCTDC 963
Query: 265 STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324
+ CTC G+ G+ C+ + CT S C NG TC + G S+TC C PG+TG C+ +
Sbjct: 964 VDSYTCTCPAGFSGIHCENNTPDCTESS-CFNGGTCVD-GINSFTCLCPPGFTGSYCQHD 1021
Query: 325 LSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGA 384
++ECDS PC +GG+C+D Y C CP GY G +C++ C SPC NGG C + +
Sbjct: 1022 VNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTH--T 1079
Query: 385 NYACECPPNFTGSNCEKKVDRC----------TSNPCANGGQCLNRGPSRMCRCRPGFTG 434
Y CECP +TG C+ C + C +GG C++ G + CRC+ G+TG
Sbjct: 1080 QYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTG 1139
Query: 435 TYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRAT 494
+YCE V +C+ +PC +G TC D G C C AG+ G C ID C S PC N T
Sbjct: 1140 SYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCS--EEIDECLSHPCQNGGT 1197
Query: 495 CYTDLSTDTFVCNCPYGFVGSRCEFPV 521
C DL +T+ C+CP G G CE V
Sbjct: 1198 CL-DLP-NTYKCSCPRGTQGVHCEINV 1222
Score = 239 bits (611), Expect = 5e-63
Identities = 134/382 (35%), Positives = 181/382 (47%), Gaps = 41/382 (10%)
Query: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLS---CLPGWTGEYCQQPI--C 222
YR C Y G NC C+ H G C N + CLPG+ G +C++ I C
Sbjct: 891 YRCHCQAGYSGRNCETDIDDCRPNPCHNGGS-CTDGINTAFCDCLPGFRGTFCEEDINEC 949
Query: 223 LSGCHEQNGYCSKPAE---CLCRPGWQGRLCN----ECIPHNGCRHGTCS---TPWQCTC 272
S C+ + C C G+ G C +C + GTC + C C
Sbjct: 950 ASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLC 1009
Query: 273 DEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNP 332
G+ G +C D+N C PC +G TC + G SY CTC GYTG +C+ + CDS+P
Sbjct: 1010 PPGFTGSYCQHDVNECDSQ-PCLHGGTCQD-GCGSYRCTCPQGYTGPNCQNLVHWCDSSP 1067
Query: 333 CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP----------CFNGGSCRERNQ 382
C+NGG C Y C CP G+ GL+C+ ++SC + C +GG C +
Sbjct: 1068 CKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDA-- 1125
Query: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVS 442
G + C C +TGS CE VD C+ +PC NG C + C+C G+ G C +
Sbjct: 1126 GNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEID 1185
Query: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS-----IDACASSP-CFNRATCY 496
+C +PC +GGTC DL N C+CP G G CE+ +D + SP CFN TC
Sbjct: 1186 ECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCV 1245
Query: 497 TDLSTDTFVCNCPYGFVGSRCE 518
+ + C CP GFVG RCE
Sbjct: 1246 DQVG--GYSCTCPPGFVGERCE 1265
Score = 236 bits (603), Expect = 4e-62
Identities = 131/388 (33%), Positives = 184/388 (47%), Gaps = 41/388 (10%)
Query: 170 SYRVICSDNYYGDNCSR----------LCKKR---NDHFGHYVCQPDGNLSCLPGWTGEY 216
SY C +++G C + LC+ ++ G Y C C TG
Sbjct: 161 SYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCV------CRATHTGPN 214
Query: 217 CQQP-ICLSGCHEQNGYCSKPA-----ECLCRPGWQGRLCNECI---PHNGCRHGTCSTP 267
C++P + S QNG +P EC C PG+ G+ C E I P N C++G
Sbjct: 215 CERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVD 274
Query: 268 ----WQCTCDEGWGGLFCDQDLNYCT-HHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE 322
+ C C W G +C +D++ C + C+NG TC N+ Y C C G+TG DC
Sbjct: 275 GVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNT-HGGYNCVCVNGWTGEDCS 333
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
+ +C S C +G +C D+ ++C CP G GL C H +C +PC G +C
Sbjct: 334 ENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLC-HLNDACISNPCNEGSNCDTNPV 392
Query: 383 GANYACECPPNFTGSNCEKKVDRCT--SNPCANGGQCLNRGPSRMCRCRPGFTGTYCELH 440
C CP +TG C + VD C+ +NPC + G+C+N S C+C G+TG CE+
Sbjct: 393 NGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEID 452
Query: 441 VSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS 500
V++C NPC + TC D C C G+ G CEV T D CASSPC + C ++
Sbjct: 453 VNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT--DECASSPCLHNGRCLDKIN 510
Query: 501 TDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
F C CP GF G C++ V S P
Sbjct: 511 E--FQCECPTGFTGHLCQYDVDECASTP 536
Score = 234 bits (596), Expect = 3e-61
Identities = 130/377 (34%), Positives = 181/377 (48%), Gaps = 35/377 (9%)
Query: 170 SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLS----CLPGWTGEYCQQPI- 221
SYR +C + G NC R C G C+P G+++ CLPG+TG+ C++ I
Sbjct: 201 SYRCVCRATHTGPNCERPYVPCSPSPCQNGG-TCRPTGDVTHECACLPGFTGQNCEENID 259
Query: 222 -CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNECIPH-----NGCRHG-TCSTP---W 268
C + G C C C P W G+ C E + N C++G TC +
Sbjct: 260 DCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGY 319
Query: 269 QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC 328
C C GW G C ++++ C + C +GATC + S+ C C G TG+ C L C
Sbjct: 320 NCVCVNGWTGEDCSENIDDCAS-AACFHGATCHDR-VASFYCECPHGRTGLLCHLN-DAC 376
Query: 329 DSNPCRNGGSCKDQEDGYH--CLCPPGYYGLHCEHSTLSCA--DSPCFNGGSCRERNQGA 384
SNPC G +C C CP GY G C C+ +PC + G C N
Sbjct: 377 ISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCI--NTLG 434
Query: 385 NYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC 444
++ C+C +TG CE V+ C SNPC N CL++ C C PG+ G +CE++ +C
Sbjct: 435 SFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDEC 494
Query: 445 ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTF 504
A +PC H G C D N C CP GF+G C+ +D CAS+PC N A C +T+
Sbjct: 495 ASSPCLHNGRCLDKINEFQCECPTGFTGHLCQY--DVDECASTPCKNGAKCLD--GPNTY 550
Query: 505 VCNCPYGFVGSRCEFPV 521
C C G+ G+ CE +
Sbjct: 551 TCVCTEGYTGTHCEVDI 567
Score = 233 bits (593), Expect = 6e-61
Identities = 148/434 (34%), Positives = 192/434 (44%), Gaps = 88/434 (20%)
Query: 170 SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLSCL--PGWTGEYCQQPI--- 221
SY C + G +C C + + G + +CL PG+TG YCQ +
Sbjct: 966 SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNEC 1025
Query: 222 ----CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECI---PHNGCRHG----TCSTPWQC 270
CL G Q+G S C C G+ G C + + C++G T ++C
Sbjct: 1026 DSQPCLHGGTCQDGCGSY--RCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRC 1083
Query: 271 TCDEGWGGLFCDQDLNYC--------------------------THH------------- 291
C GW GL+CD C THH
Sbjct: 1084 ECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCE 1143
Query: 292 --------SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQE 343
SPC+NGATC++ Y+C C GY GV+C E+ EC S+PC+NGG+C D
Sbjct: 1144 DLVDECSPSPCQNGATCTDY-LGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLP 1202
Query: 344 DGYHCLCPPGYYGLHCEHSTLSC-------ADSP-CFNGGSCRERNQGANYACECPPNFT 395
+ Y C CP G G+HCE + C + SP CFN G+C ++ G Y+C CPP F
Sbjct: 1203 NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGG--YSCTCPPGFV 1260
Query: 396 GSNCEKKVDRCTSNPC-ANGGQ-CLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
G CE V+ C SNPC A G Q C+ R C CR G TG CE ++ C PC +GG
Sbjct: 1261 GERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGG 1320
Query: 454 TCHDLEN---GLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPY 510
TC N G +C CPAGF G CE C S C N TC + + T +C P
Sbjct: 1321 TCAVASNTARGFICKCPAGFEGATCE--NDARTCGSLRCLNGGTCISGPRSPTCLCLGP- 1377
Query: 511 GFVGSRCEFPVGLP 524
F G C+FP P
Sbjct: 1378 -FTGPECQFPASSP 1390
Score = 219 bits (557), Expect = 9e-57
Identities = 122/334 (36%), Positives = 166/334 (49%), Gaps = 29/334 (8%)
Query: 208 CLPGWTGEYCQQ-PICLSGCHEQNGYCSKPAE----CLCRPGWQGRLC----NECIPHNG 258
C PGW+G+ CQQ C S G C P E C C P + G C NEC G
Sbjct: 129 CPPGWSGKSCQQADPCASNPCANGGQC-LPFEASYICHCPPSFHGPTCRQDVNECGQKPG 187
Query: 259 -CRH-GTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCR 313
CRH GTC ++C C G C++ C+ SPC+NG TC +G ++ C C
Sbjct: 188 LCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCS-PSPCQNGGTCRPTGDVTHECACL 246
Query: 314 PGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--C 371
PG+TG +CE + +C N C+NGG+C D + Y+C CPP + G +C C P C
Sbjct: 247 PGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNAC 306
Query: 372 FNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPG 431
NGG+C + G Y C C +TG +C + +D C S C +G C +R S C C G
Sbjct: 307 QNGGTCHNTHGG--YNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHG 364
Query: 432 FTGTYCELHVSDCARNPCAHGGTC--HDLENGLMCTCPAGFSGRRCEVRTSIDACA--SS 487
TG C L+ C NPC G C + + +CTCP+G++G C +D C+ ++
Sbjct: 365 RTGLLCHLN-DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACS--QDVDECSLGAN 421
Query: 488 PCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
PC + C L +F C C G+ G RCE V
Sbjct: 422 PCEHAGKCINTLG--SFECQCLQGYTGPRCEIDV 453
Score = 217 bits (552), Expect = 3e-56
Identities = 122/360 (33%), Positives = 162/360 (45%), Gaps = 66/360 (18%)
Query: 214 GEYCQQP--ICLSG--CHEQNGYCSKPAECLCRPGWQGRLC---NECIPHNGCRHGTCST 266
G C QP CL+G C NG C+C + G C N C+ GTC
Sbjct: 21 GPRCSQPGETCLNGGKCEAANG----TEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHV 76
Query: 267 -------PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGV 319
+ C+C G+ G C L+ +PC+NG TC Y C C PG++G
Sbjct: 77 VDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGK 136
Query: 320 DCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYY------------------------ 355
C+ + C SNPC NGG C E Y C CPP ++
Sbjct: 137 SCQ-QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTC 195
Query: 356 ----------------GLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNC 399
G +CE + C+ SPC NGG+CR + C C P FTG NC
Sbjct: 196 HNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGD-VTHECACLPGFTGQNC 254
Query: 400 EKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC--ARNPCAHGGTCHD 457
E+ +D C N C NGG C++ + CRC P +TG YC V +C N C +GGTCH+
Sbjct: 255 EENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHN 314
Query: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
G C C G++G C +ID CAS+ CF+ ATC+ ++ +F C CP+G G C
Sbjct: 315 THGGYNCVCVNGWTGEDCS--ENIDDCASAACFHGATCHDRVA--SFYCECPHGRTGLLC 370
Score = 213 bits (542), Expect = 5e-55
Identities = 122/393 (31%), Positives = 168/393 (42%), Gaps = 54/393 (13%)
Query: 170 SYRVICSDNYYGDNCSRL--------CKKRNDHFG---HYVCQPDGNLSCLPGWTGEYCQ 218
SYR C Y G NC L CK + Y C+ C GWTG YC
Sbjct: 1042 SYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCE------CPSGWTGLYCD 1095
Query: 219 QP------------ICLSGCHEQNGYC---SKPAECLCRPGWQGRLC----NECIPHNGC 259
P + ++ + G C C C+ G+ G C +EC P + C
Sbjct: 1096 VPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSP-SPC 1154
Query: 260 RHGTCSTPW----QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPG 315
++G T + C C G+ G+ C ++++ C H PC+NG TC + +Y C+C G
Sbjct: 1155 QNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH-PCQNGGTCLDL-PNTYKCSCPRG 1212
Query: 316 YTGVDCELELSECD--------SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCA 367
GV CE+ + +C+ S C N G+C DQ GY C CPPG+ G CE C
Sbjct: 1213 TQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECL 1272
Query: 368 DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL---NRGPSR 424
+PC G+ + ++ CEC TG CE ++ C PC NGG C N
Sbjct: 1273 SNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGF 1332
Query: 425 MCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
+C+C GF G CE C C +GGTC C C F+G C+ S
Sbjct: 1333 ICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCL 1392
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
+PC+N+ TC + + C CP F G C
Sbjct: 1393 GGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLC 1425
Score = 157 bits (396), Expect = 4e-38
Identities = 86/232 (37%), Positives = 112/232 (48%), Gaps = 14/232 (6%)
Query: 294 CKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED----GYHCL 349
C NG C + + C C + G C+ + + C S PC+N G+C + Y C
Sbjct: 31 CLNGGKCE-AANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVDRRGVADYACS 88
Query: 350 CPPGYYGLHC-EHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
C G+ G C +C +PC NGG+C + Y C CPP ++G +C++ D C S
Sbjct: 89 CALGFSGPLCLTPLDNACLTNPCRNGGTC-DLLTLTEYKCRCPPGWSGKSCQQ-ADPCAS 146
Query: 409 NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNP--CAHGGTCHDLENGLMCTC 466
NPCANGGQCL S +C C P F G C V++C + P C HGGTCH+ C C
Sbjct: 147 NPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVC 206
Query: 467 PAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
A +G CE C+ SPC N TC T C C GF G CE
Sbjct: 207 RATHTGPNCE--RPYVPCSPSPCQNGGTC-RPTGDVTHECACLPGFTGQNCE 255
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 5/75 (6%)
Query: 449 CAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYT--DLSTDTFVC 506
C +GG C C C F G RC+ + C S+PC N TC+ + C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ---DPNPCLSTPCKNAGTCHVVDRRGVADYAC 87
Query: 507 NCPYGFVGSRCEFPV 521
+C GF G C P+
Sbjct: 88 SCALGFSGPLCLTPL 102
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 258 bits (658), Expect = 2e-68
Identities = 133/371 (35%), Positives = 178/371 (47%), Gaps = 57/371 (15%)
Query: 208 CLPGWTGEYCQQPI--CLSGCHEQNGYCSKPAE---CLCRPGWQGRLC----NECIPHNG 258
C PG+TG+ C I C S + C C+C G C NEC+ N
Sbjct: 670 CSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLS-NP 728
Query: 259 CRHGTCS---TPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPG 315
C HG C+ + ++C CD GW G+ C+ D N C + PC+NG TC N Y CTC+ G
Sbjct: 729 CIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSN-PCQNGGTCDNL-VNGYRCTCKKG 786
Query: 316 YTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGG 375
+ G +C++ + EC SNPC N G+C D GY C C Y G +C+ C+ +PC N
Sbjct: 787 FKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAA 846
Query: 376 SCRE--------------------------------------RNQGANYACECPPNFTGS 397
C+E N +Y CECPP F+G
Sbjct: 847 VCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGM 906
Query: 398 NCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHD 457
+CE+ +D C +NPC NGG C++ + C C PGFTG C+ +++C PC +GGTC D
Sbjct: 907 DCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSD 966
Query: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
N C C AGF G CE +I+ C S CFN TC +++ F C CP GF GS C
Sbjct: 967 YVNSYTCKCQAGFDGVHCE--NNINECTESSCFNGGTCVDGINS--FSCLCPVGFTGSFC 1022
Query: 518 EFPVGLPPSFP 528
+ S P
Sbjct: 1023 LHEINECSSHP 1033
Score = 248 bits (634), Expect = 1e-65
Identities = 143/391 (36%), Positives = 188/391 (48%), Gaps = 66/391 (16%)
Query: 193 DHFGHYVCQPDGNLSCLPGWTGEYCQQPICL---SGCHEQNGYCSKPAE--CLCRPGWQG 247
D G Y C SC G+TG+ CQ + L S C + K AE CLC GW G
Sbjct: 1042 DGLGTYRC------SCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAG 1095
Query: 248 RLCN----EC---------IPHNGCRH-GTC---STPWQCTCDEGWGGLFCDQDLNYCTH 290
C+ C + + C+H G C C C G+ G +C++ L+ C
Sbjct: 1096 AYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECAS 1155
Query: 291 HSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLC 350
+ PC++GATCS+ Y C C PGY GV+CE E+ EC + PC+NGG+C D + + C C
Sbjct: 1156 N-PCQHGATCSDF-IGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSC 1213
Query: 351 PPGYYGLHCEHSTLSCADSP-CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSN 409
PPG GL CE + CA P C NGG C +R G Y+C C P F G CE ++ C SN
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGG--YSCRCLPGFAGERCEGDINECLSN 1271
Query: 410 PCANGGQ--CLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC---HDLENGLMC 464
PC++ G C+ +C CR FTG +CE V C + PC +GGTC ++ +G +C
Sbjct: 1272 PCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFIC 1331
Query: 465 TCPAGFSGRRCEV---------------------------RTSIDACASSPCFNRATCYT 497
CP GFSG RC+ R CASSPC + +C+
Sbjct: 1332 RCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHP 1391
Query: 498 DLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
+ C C F GSRCE PPS P
Sbjct: 1392 QRQPPYYSCQCAPPFSGSRCELYTA-PPSTP 1421
Score = 247 bits (630), Expect = 3e-65
Identities = 134/373 (35%), Positives = 189/373 (50%), Gaps = 30/373 (8%)
Query: 171 YRVICSDNYYGDNC-SRLCKKRNDHFGHYVCQPDGNLS-----CLPGWTGEYCQ--QPIC 222
+R IC + + +C S++ + ++ H C G LS C GW G C+ + C
Sbjct: 704 FRCICPEGPHHPSCYSQVNECLSNPCIHGNCT--GGLSGYKCLCDAGWVGINCEVDKNEC 761
Query: 223 LSGCHEQNGYCSKPAE---CLCRPGWQGRLC----NECIPHNGCRHGTCS---TPWQCTC 272
LS + G C C C+ G++G C +EC + GTC + + C C
Sbjct: 762 LSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHC 821
Query: 273 DEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ-RSYTCTCRPGYTGVDCELELSECDSN 331
+ G C L C+ + PC+N A C S SYTC C PG+ G C +++ EC S
Sbjct: 822 VLPYTGKNCQTVLAPCSPN-PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISK 880
Query: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGAN-YACEC 390
PC N G C + + Y C CPPG+ G+ CE C +PC NGGSC + G N ++C C
Sbjct: 881 PCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMD---GVNTFSCLC 937
Query: 391 PPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCA 450
P FTG C+ ++ C S PC NGG C + S C+C+ GF G +CE ++++C + C
Sbjct: 938 LPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCF 997
Query: 451 HGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPY 510
+GGTC D N C CP GF+G C I+ C+S PC N TC L T+ C+CP
Sbjct: 998 NGGTCVDGINSFSCLCPVGFTGSFC--LHEINECSSHPCLNEGTCVDGLG--TYRCSCPL 1053
Query: 511 GFVGSRCEFPVGL 523
G+ G C+ V L
Sbjct: 1054 GYTGKNCQTLVNL 1066
Score = 243 bits (620), Expect = 4e-64
Identities = 140/419 (33%), Positives = 191/419 (45%), Gaps = 82/419 (19%)
Query: 170 SYRVICSDNYYGDNC--------SRLCKKR---NDHFGHYVCQPDGNLSCLPGWTGEYCQ 218
SY +C+ + G C S+ C ++ G Y+C+ C PG++G C+
Sbjct: 856 SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCE------CPPGFSGMDCE 909
Query: 219 QPI--CLSGCHEQNGYCSKPAE---CLCRPGWQGRLC----NECIPHNGCRHGTCS---T 266
+ I CL+ + G C CLC PG+ G C NEC+ GTCS
Sbjct: 910 EDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969
Query: 267 PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS 326
+ C C G+ G+ C+ ++N CT S C NG TC + G S++C C G+TG C E++
Sbjct: 970 SYTCKCQAGFDGVHCENNINECTESS-CFNGGTCVD-GINSFSCLCPVGFTGSFCLHEIN 1027
Query: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRER------ 380
EC S+PC N G+C D Y C CP GY G +C+ C+ SPC N G+C ++
Sbjct: 1028 ECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQC 1087
Query: 381 ----------------------------------------NQGANYACECPPNFTGSNCE 400
N G + C+CP +TGS CE
Sbjct: 1088 LCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE 1147
Query: 401 KKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLEN 460
+++D C SNPC +G C + C C PG+ G CE V +C PC +GGTC DL N
Sbjct: 1148 EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVN 1207
Query: 461 GLMCTCPAGFSGRRCEVRTSIDACASSP-CFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C+CP G G CE +ID CA P C N C + + C C GF G RCE
Sbjct: 1208 HFKCSCPPGTRGLLCE--ENIDDCARGPHCLNGGQCMDRIG--GYSCRCLPGFAGERCE 1262
Score = 238 bits (608), Expect = 1e-62
Identities = 130/380 (34%), Positives = 179/380 (47%), Gaps = 75/380 (19%)
Query: 193 DHFGHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGCHEQNGYCSKPA---ECLCRPGWQG 247
D G + C C+PG+ G +C+ I C S NG C +CLC PG+ G
Sbjct: 473 DKIGGFTCL------CMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTG 526
Query: 248 RLCNECIPH-------NGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCT----HHSPCKN 296
+C I NG + ++C C G+ G+ C+++++ C HH C++
Sbjct: 527 PVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQD 586
Query: 297 GATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYG 356
G SYTC C PGY G C ++ EC S+PC N G C D +GY C C PG G
Sbjct: 587 GID-------SYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 639
Query: 357 LHCEHSTLSCADSPCFNGGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNPCANGG 415
++CE + CA +PC + G C + G N Y+C C P FTG C +D C SNPC G
Sbjct: 640 VNCEINFDDCASNPCIH-GICMD---GINRYSCVCSPGFTGQRCNIDIDECASNPCRKGA 695
Query: 416 QCLN----------RGPSR---------------------------MCRCRPGFTGTYCE 438
C+N GP C C G+ G CE
Sbjct: 696 TCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCE 755
Query: 439 LHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTD 498
+ ++C NPC +GGTC +L NG CTC GF G C+V +ID CAS+PC N+ TC+ D
Sbjct: 756 VDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQV--NIDECASNPCLNQGTCFDD 813
Query: 499 LSTDTFVCNCPYGFVGSRCE 518
+S + C+C + G C+
Sbjct: 814 IS--GYTCHCVLPYTGKNCQ 831
Score = 235 bits (599), Expect = 1e-61
Identities = 129/382 (33%), Positives = 180/382 (47%), Gaps = 52/382 (13%)
Query: 169 YSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDG---------NLSCLPGWTGEYCQQ 219
+++ C + G C R D ++ CQ G N C P WTG++C +
Sbjct: 242 FTFECNCLPGFEGSTCER----NIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTE 297
Query: 220 PI---------CLSG--CHEQNGYCSKPAECLCRPGWQGRLCNE---------CIPHNGC 259
+ C +G C +NG C+C GW G C+E C P + C
Sbjct: 298 DVDECLLQPNACQNGGTCANRNGGYG----CVCVNGWSGDDCSENIDDCAFASCTPGSTC 353
Query: 260 RHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC-SNSGQRSYTCTCRPGYTG 318
S + C C EG GL C D + C + PC GA C +N Y CTC GY G
Sbjct: 354 IDRVAS--FSCMCPEGKAGLLCHLD-DACISN-PCHKGALCDTNPLNGQYICTCPQGYKG 409
Query: 319 VDCELELSEC---DSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGG 375
DC ++ EC +SNPC + G C + + +HC C GY G CE C PC N
Sbjct: 410 ADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDA 469
Query: 376 SCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGT 435
+C ++ G + C C P F G +CE +++ C SNPC N GQC+++ C C PGFTG
Sbjct: 470 TCLDKIGG--FTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Query: 436 YCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATC 495
C++ + DC+ PC +G C D NG C C GF+G CE +ID C PC + C
Sbjct: 528 VCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCE--ENIDNCDPDPC-HHGQC 584
Query: 496 YTDLSTDTFVCNCPYGFVGSRC 517
+ D++ C C G++G+ C
Sbjct: 585 QDGI--DSYTCICNPGYMGAIC 604
Score = 223 bits (569), Expect = 3e-58
Identities = 116/344 (33%), Positives = 164/344 (47%), Gaps = 31/344 (9%)
Query: 196 GHYVCQPDGNLSCLPGWTGEYCQQ---PICLSGCHEQNGYCSKPA----ECLCRPGWQGR 248
G Y CQ C G+TG+YC P S C G C + EC C PG++G
Sbjct: 203 GSYQCQ------CPQGFTGQYCDSLYVPCAPSPC-VNGGTCRQTGDFTFECNCLPGFEGS 255
Query: 249 LCNECI---PHNGCRHGTCSTP----WQCTCDEGWGGLFCDQDLNYCT-HHSPCKNGATC 300
C I P++ C++G + C C W G FC +D++ C + C+NG TC
Sbjct: 256 TCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTC 315
Query: 301 SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE 360
+N Y C C G++G DC + +C C G +C D+ + C+CP G GL C
Sbjct: 316 ANRNG-GYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLC- 373
Query: 361 HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT---SNPCANGGQC 417
H +C +PC G C Y C CP + G++C + VD C SNPC + G+C
Sbjct: 374 HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKC 433
Query: 418 LNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV 477
+N + C C G+ G CE+ +++C +PC + TC D G C C GF G CE+
Sbjct: 434 VNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCEL 493
Query: 478 RTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
I+ C S+PC N C ++ F C CP GF G C+ +
Sbjct: 494 E--INECQSNPCVNNGQCVDKVNR--FQCLCPPGFTGPVCQIDI 533
Score = 218 bits (554), Expect = 2e-56
Identities = 119/333 (35%), Positives = 168/333 (50%), Gaps = 27/333 (8%)
Query: 204 GNLSCLPGWTGEYCQ-QPICLSGCHEQNGYCSK-----PAECLCRPGWQGRLC-----NE 252
G C G+ GEYCQ + C + G C A C C G+ G C +
Sbjct: 49 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 108
Query: 253 CIPHNGCRH-GTC----STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRS 307
C C + GTC ++CTC G+ G C Q + C H PC NG+TC+ +
Sbjct: 109 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCTTVANQ- 165
Query: 308 YTCTCRPGYTGVDCELELSECD-SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
++C C G+TG CE +++ECD C++GG+C + Y C CP G+ G +C+ + C
Sbjct: 166 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPC 225
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426
A SPC NGG+CR+ + C C P F GS CE+ +D C ++ C NGG C++ + C
Sbjct: 226 APSPCVNGGTCRQTGD-FTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNC 284
Query: 427 RCRPGFTGTYCELHVSDCARNP--CAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
RC P +TG +C V +C P C +GGTC + G C C G+SG C +ID C
Sbjct: 285 RCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS--ENIDDC 342
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
A + C +TC ++ +F C CP G G C
Sbjct: 343 AFASCTPGSTCIDRVA--SFSCMCPEGKAGLLC 373
Score = 217 bits (553), Expect = 3e-56
Identities = 129/378 (34%), Positives = 177/378 (46%), Gaps = 43/378 (11%)
Query: 175 CSDNYYGDNC----------SRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQ-QPICL 223
C+ + G++C SR C N H + + +C G+TG+ CQ CL
Sbjct: 92 CASGFTGEDCQYSTSHPCFVSRPCL--NGGTCHMLSRDTYECTCQVGFTGKECQWTDACL 149
Query: 224 SGCHEQNGYCSKPAE---CLCRPGWQGRLC----NECIPHNGCRHG-TCST---PWQCTC 272
S C+ A C C G+ G+ C NEC C+HG TC +QC C
Sbjct: 150 SHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQC 209
Query: 273 DEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNP 332
+G+ G +CD C SPC NG TC +G ++ C C PG+ G CE + +C ++
Sbjct: 210 PQGFTGQYCDSLYVPCAP-SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR 268
Query: 333 CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--CFNGGSCRERNQGANYACEC 390
C+NGG C D + Y+C CPP + G C C P C NGG+C RN G Y C C
Sbjct: 269 CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGG--YGCVC 326
Query: 391 PPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD-CARNPC 449
++G +C + +D C C G C++R S C C G G C H+ D C NPC
Sbjct: 327 VNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLC--HLDDACISNPC 384
Query: 450 AHGGTC--HDLENGLMCTCPAGFSGRRCEVRTSIDACA---SSPCFNRATCYTDLSTD-T 503
G C + L +CTCP G+ G C +D CA S+PC + C ++TD
Sbjct: 385 HKGALCDTNPLNGQYICTCPQGYKGADC--TEDVDECAMANSNPCEHAGKC---VNTDGA 439
Query: 504 FVCNCPYGFVGSRCEFPV 521
F C C G+ G RCE +
Sbjct: 440 FHCECLKGYAGPRCEMDI 457
Score = 165 bits (418), Expect = 1e-40
Identities = 89/233 (38%), Positives = 112/233 (48%), Gaps = 11/233 (4%)
Query: 291 HSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQE--DGYHC 348
+ PC N C + C C G+ G C+ C+ N C+NGG+C Q C
Sbjct: 32 YEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATC 90
Query: 349 LCPPGYYGLHCEHSTL--SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC 406
C G+ G C++ST PC NGG+C ++ Y C C FTG C+ D C
Sbjct: 91 RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD-TYECTCQVGFTGKECQ-WTDAC 148
Query: 407 TSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC-ARNPCAHGGTCHDLENGLMCT 465
S+PCANG C C+C GFTG CE V++C C HGGTC +L C
Sbjct: 149 LSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQ 208
Query: 466 CPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
CP GF+G+ C+ + CA SPC N TC TF CNC GF GS CE
Sbjct: 209 CPQGFTGQYCD--SLYVPCAPSPCVNGGTC-RQTGDFTFECNCLPGFEGSTCE 258
Score = 132 bits (332), Expect = 1e-30
Identities = 109/399 (27%), Positives = 154/399 (38%), Gaps = 87/399 (21%)
Query: 175 CSDN--YYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGCHEQN 230
C+ N +G CS D G Y C+ C+PG+ G C+ + C + +
Sbjct: 1153 CASNPCQHGATCS-------DFIGGYRCE------CVPGYQGVNCEYEVDECQNQPCQNG 1199
Query: 231 GYCSKPA---ECLCRPGWQGRLCNECI------PH--NGCRHGTCSTPWQCTCDEGWGGL 279
G C +C C PG +G LC E I PH NG + + C C G+ G
Sbjct: 1200 GTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGE 1259
Query: 280 FCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC 339
C+ D+N C + G+ Y C CR +TG CE + C PC NGG+C
Sbjct: 1260 RCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTC 1319
Query: 340 ---KDQEDGYHCLCPPGYYGLHCEHS-----------------------------TLSCA 367
+ DG+ C CPPG+ G C+ S CA
Sbjct: 1320 AVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCA 1379
Query: 368 DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC- 426
SPC +GGSC + Q Y+C+C P F+GS CE T+ P CL S+ C
Sbjct: 1380 SSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE----LYTAPPSTPPATCL----SQYCA 1431
Query: 427 -RCRPGFTGTYCELHVSDCARNPCAHGGTCH-DLEN-GLMCTCPA---GFSGRRCEVRTS 480
+ R G C H GG C +EN C+ P + +C+
Sbjct: 1432 DKARDGVCDEACNSHACQW------DGGDCSLTMENPWANCSSPLPCWDYINNQCD---- 1481
Query: 481 IDACASSPC-FNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
+ C + C F+ C + T + C F + C+
Sbjct: 1482 -ELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCD 1519
Score = 92.8 bits (229), Expect = 9e-19
Identities = 44/113 (38%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 410 PCANGGQCLN-RGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC--HDLENGLMCTC 466
PC N G C+ + C+C GF G YC+ H C +N C +GGTC + C C
Sbjct: 34 PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRC 92
Query: 467 PAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF 519
+GF+G C+ TS S PC N TC+ LS DT+ C C GF G C++
Sbjct: 93 ASGFTGEDCQYSTSHPCFVSRPCLNGGTCHM-LSRDTYECTCQVGFTGKECQW 144
Score = 57.8 bits (138), Expect = 3e-08
Identities = 31/104 (29%), Positives = 39/104 (37%), Gaps = 18/104 (17%)
Query: 422 PSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGL-MCTCPAGFSGRRCEVRTS 480
P+ +CR G+ PC + G C NG C CP GF G C+ R
Sbjct: 22 PAHALQCRDGY--------------EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-- 65
Query: 481 IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524
D C + C N TC C C GF G C++ P
Sbjct: 66 -DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 108
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 242 bits (617), Expect = 1e-63
Identities = 140/392 (35%), Positives = 196/392 (50%), Gaps = 51/392 (13%)
Query: 159 EQTSTLTRLRYSYRVICSDNYYGDNC---SRLCK----KRN----DHFGHYVCQPDGNLS 207
E ST L SY+ +C ++ G+ C S CK K N D + Y C+
Sbjct: 743 EHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCE------ 796
Query: 208 CLPGWTGEYCQQPI-------CLSG--CHEQNGYCSKPAE--CLCRPGWQGRLC----NE 252
C GWTG+ C + I C++G CHE + P + CLC P + G+ C N
Sbjct: 797 CTSGWTGQNCSEEINECDSDPCMNGGLCHES----TIPGQFVCLCPPLYTGQFCHQRYNL 852
Query: 253 C-IPHNGCR-HGTC----STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQR 306
C + HN CR + TC C C E + G C+ D+ C S C++ C +
Sbjct: 853 CDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS-CQDYGDCEDM-VN 910
Query: 307 SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
++ C CRPG++G CE+E++EC S PC+N G+C D + + C C P Y+G CE C
Sbjct: 911 NFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKC 970
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426
SPC + +C R G Y C C P +TG NCE +D C S PC + G C++ C
Sbjct: 971 KISPCLDEENCVYRTDG--YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTC 1028
Query: 427 RCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACAS 486
C+ GF GT+CE + +DC NPC H G C +L N C+C A + +C+++ I+ C S
Sbjct: 1029 DCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIK--INDCTS 1085
Query: 487 SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
PC N C S F C CP G+ G+ CE
Sbjct: 1086 IPCMNEGFC--QKSAHGFTCICPRGYTGAYCE 1115
Score = 216 bits (550), Expect = 6e-56
Identities = 139/433 (32%), Positives = 189/433 (43%), Gaps = 89/433 (20%)
Query: 159 EQTSTLTRLRYSYRVICSDNYYGDNCSR--------------LCKKRNDHFGHYVCQPDG 204
+ ST T L SYR C+ + G NCS LC + G +VC
Sbjct: 781 KNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIP-GQFVCL--- 836
Query: 205 NLSCLPGWTGEYCQQPICL-----------SGC-----HEQNGYCSKPAE---------- 238
C P +TG++C Q L S C Q+ C + E
Sbjct: 837 ---CPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD 893
Query: 239 --------------------CLCRPGWQGRLC----NECIPHNGCRHGTC---STPWQCT 271
C+CRPG+ G LC NEC +GTC + + C
Sbjct: 894 CLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCN 953
Query: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
C+ + G FC+ D+N C SPC + C Y C C PGYTG++CE+ L EC S
Sbjct: 954 CEPEYHGPFCELDVNKCKI-SPCLDEENCVYRTD-GYNCLCAPGYTGINCEINLDECLSE 1011
Query: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391
PC + G C D + Y C C G++G HCE + C +PC +G N+ Y C C
Sbjct: 1012 PCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINE---YPCSCD 1068
Query: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNP--- 448
+ T + C+ K++ CTS PC N G C C C G+TG YCE + +CA
Sbjct: 1069 ADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNS 1128
Query: 449 --CAHGGTCHDLENGLM-CTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFV 505
C +GG C D C C GFSG+ CE+ +I+ C+SSPC + A C ++ +V
Sbjct: 1129 VICLNGGICVDGPGHTFDCRCLPGFSGQFCEI--NINECSSSPCLHGADCEDHING--YV 1184
Query: 506 CNCPYGFVGSRCE 518
C C G+ G CE
Sbjct: 1185 CKCQPGWSGHHCE 1197
Score = 209 bits (533), Expect = 5e-54
Identities = 113/317 (35%), Positives = 153/317 (48%), Gaps = 21/317 (6%)
Query: 208 CLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTP 267
C+PG+ G C+ I H C A C+ +PG C +C+P G
Sbjct: 669 CVPGFKGTQCEIDIDECASHP----CKNGATCIDQPG--NYFC-QCVPPFKVVDG----- 716
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
+ C C+ G+ G+ C+QD++ C ++ C++ +TC + SY C C + G CE E +E
Sbjct: 717 FSCLCNPGYVGIRCEQDIDDCILNA-CEHNSTCKDL-HLSYQCVCLSDWEGNFCEQESNE 774
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C NPC+N +C D Y C C G+ G +C C PC NGG C E +
Sbjct: 775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFV 834
Query: 388 CECPPNFTGSNCEKKVDRC--TSNPCANGGQCLNR-GPSRMCRCRPGFTGTYCELHVSDC 444
C CPP +TG C ++ + C NPC N CL ++ C CR F G CE+ V DC
Sbjct: 835 CLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDC 894
Query: 445 ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTF 504
C G C D+ N C C GFSG CE+ I+ C+S PC N TC DL T+ F
Sbjct: 895 LFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEI--EINECSSEPCKNNGTC-VDL-TNRF 950
Query: 505 VCNCPYGFVGSRCEFPV 521
CNC + G CE V
Sbjct: 951 FCNCEPEYHGPFCELDV 967
Score = 137 bits (345), Expect = 3e-32
Identities = 76/260 (29%), Positives = 111/260 (42%), Gaps = 12/260 (4%)
Query: 253 CIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNS----GQRSY 308
C H C S + C C + G +C Q+L+ C+ PCKN +C N +++Y
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCINKRENWDEQAY 240
Query: 309 TCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCAD 368
C C P +TG +C + +C + C +G + + C C + G CE S C
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
Query: 369 SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRC 428
+ G C N + Y ECP + N E V + PC NG C+ MC C
Sbjct: 301 LLFWKRGICP--NSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
Query: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC--AS 486
P FT C+ + C P + TC E C+C +GF+ + CE +ID C S
Sbjct: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE--KAIDHCKLLS 416
Query: 487 SPCFNRATCYTDLSTDTFVC 506
C N C+ + +VC
Sbjct: 417 INCLNEEWCFNIIGRFKYVC 436
Score = 125 bits (315), Expect = 1e-28
Identities = 108/471 (22%), Positives = 152/471 (32%), Gaps = 165/471 (35%)
Query: 200 CQPDGNLSCLPGWTGEYCQQPI--------------------------CLSGC------- 226
C+ D SC+ G+T + C++ I C+ GC
Sbjct: 388 CEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
Query: 227 -------HEQNGYCSKPAECLCR---------------PGWQGRLCNECI---------- 254
H+ YC +C+ G +G C I
Sbjct: 448 LKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANC 507
Query: 255 -------------------PHNG----CRHG-TC-----STPWQCTCDEGWGGLF----- 280
PH G C +G +C S ++ C W G
Sbjct: 508 TEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENT 567
Query: 281 CDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC------------ 328
D N C H + CK+ C+C Y G C + + C
Sbjct: 568 TDDQENECQHEAVCKDEINRPR-------CSCSLSYIGRLCVVNVDYCLGNHSISVHGLC 620
Query: 329 ----------------------DSNPCRNGGSCKDQEDGYHC------LCPPGYYGLHCE 360
D+ C++ SCK+ H C PG+ G CE
Sbjct: 621 LALSHNCNCSGLQRYERNICEIDTEDCKS-ASCKNGTTSTHLRGYFFRKCVPGFKGTQCE 679
Query: 361 HSTLSCADSPCFNGGSCRERNQGANYACECPPNF--------------TGSNCEKKVDRC 406
CA PC NG +C + Q NY C+C P F G CE+ +D C
Sbjct: 680 IDIDECASHPCKNGATCID--QPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDC 737
Query: 407 TSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
N C + C + S C C + G +CE ++C NPC + TC DL C C
Sbjct: 738 ILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCEC 797
Query: 467 PAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
+G++G+ C I+ C S PC N C+ FVC CP + G C
Sbjct: 798 TSGWTGQNCS--EEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFC 846
Score = 125 bits (313), Expect = 2e-28
Identities = 87/287 (30%), Positives = 122/287 (42%), Gaps = 43/287 (14%)
Query: 208 CLPGWTGEYCQQPICLSGCH----EQNGYC--------SKPAECLCRPGWQGRLCNE--- 252
C P ++G+YCQ+ L C + NG C + EC+C P + G+ C+E
Sbjct: 202 CQPPFSGKYCQE---LDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIG 258
Query: 253 -CIPHNGCRHGTCST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRS 307
C PH C HG CS + C CDE + G FC+ C K G C NS +
Sbjct: 259 QCQPHV-CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG-ICPNSSS-A 315
Query: 308 YTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCA 367
YT C G + + E ++SE PC+NG C + C+C P + L C+ SC
Sbjct: 316 YTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
Query: 368 DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC--TSNPCANGGQCLNRGPSRM 425
P N +C++ + +Y C C FT NCEK +D C S C N C N
Sbjct: 376 SFPLRNNATCKKCEK--DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFN------ 427
Query: 426 CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSG 472
G + + + C +NPC + + L C C F G
Sbjct: 428 ------IIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL-CYCGVTFHG 467
Score = 115 bits (289), Expect = 1e-25
Identities = 78/269 (28%), Positives = 113/269 (42%), Gaps = 44/269 (16%)
Query: 171 YRVICSDNYYGDNC--------SRLCKKRN---DHFGHYVCQPDGNLSCLPGWTGEYCQQ 219
Y +C+ Y G NC S C D HY C C G+ G +C+
Sbjct: 988 YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCD------CKSGFFGTHCET 1041
Query: 220 PI--CLSG-CHEQNGYCSKPAE---CLCRPGWQGRLC----NECIPHNGCRHGTCSTP-- 267
CLS C +G C++ C C C N+C G C
Sbjct: 1042 NANDCLSNPC--LHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAH 1099
Query: 268 -WQCTCDEGWGGLFCDQDLNYCTHHSP----CKNGATCSNSGQRSYTCTCRPGYTGVDCE 322
+ C C G+ G +C++ ++ C C NG C + ++ C C PG++G CE
Sbjct: 1100 GFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE 1159
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
+ ++EC S+PC +G C+D +GY C C PG+ G HCE+ L C + C + C E
Sbjct: 1160 ININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENE-LECIPNSCVH-ELCMENEP 1217
Query: 383 GANYACECPPNF----TGSNCEKKVDRCT 407
G+ C C P F G C ++ R T
Sbjct: 1218 GS--TCLCTPGFMTCSIGLLCGDEIRRIT 1244
Score = 98.2 bits (243), Expect = 2e-20
Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 22/241 (9%)
Query: 294 CKNGATC-SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP 352
C NG +C S + Y C + G ++ N C++ CKD+ + C C
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSL 594
Query: 353 GYYGLHCEHSTLSCADSPCFN-GGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411
Y G C + C + + G C + N C + + CE + C S C
Sbjct: 595 SYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCN--CSGLQRYERNICEIDTEDCKSASC 652
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHD-------------- 457
NG + +C PGF GT CE+ + +CA +PC +G TC D
Sbjct: 653 KNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFK 712
Query: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
+ +G C C G+ G RCE ID C + C + +TC DL ++ C C + G+ C
Sbjct: 713 VVDGFSCLCNPGYVGIRCE--QDIDDCILNACEHNSTC-KDLHL-SYQCVCLSDWEGNFC 768
Query: 518 E 518
E
Sbjct: 769 E 769
Score = 68.2 bits (165), Expect = 2e-11
Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 14/103 (13%)
Query: 398 NCEKKVDRCTSNPCA-----NGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC-----ARN 447
N + V +C ++PC+ NGG C+ G S C C G+ G++C VS C +
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH 2660
Query: 448 PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCF 490
C+ G TC L +G C CP G +G CE SI S P F
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTTGIYCEQALSI----SDPSF 2699
Score = 65.5 bits (158), Expect = 2e-10
Identities = 36/119 (30%), Positives = 60/119 (50%), Gaps = 12/119 (10%)
Query: 407 TSNPCANGGQCLNRGPSRM--CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDL-----E 459
+S C+ G+CL+ S+ C C+P F+G YC+ + C+ PC + G+C + E
Sbjct: 179 SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDE 237
Query: 460 NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C C F+G+ C I C CF+ C +++++++F+C C F G CE
Sbjct: 238 QAYECVCHPPFTGKNCS--EIIGQCQPHVCFH-GNC-SNITSNSFICECDEQFSGPFCE 292
Score = 64.7 bits (156), Expect = 3e-10
Identities = 32/78 (41%), Positives = 40/78 (51%), Gaps = 5/78 (6%)
Query: 440 HVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDL 499
HV CA + C + GTC L C CP +SG+ C+ +C ++PC N ATC
Sbjct: 2335 HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ----FASCENNPCGNGATCVPKS 2390
Query: 500 STDTFVCNCPYGFVGSRC 517
TD VC CPYG G C
Sbjct: 2391 GTD-IVCLCPYGRSGPLC 2407
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/76 (40%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC-HDLENGLMC 464
C N C NGG+C G + CRC P + G C VS C N C H C D C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 465 TCPAGFSGRRCEVRTS 480
C G+ GR CE +TS
Sbjct: 2938 LCTLGWVGRYCENKTS 2953
Score = 59.7 bits (143), Expect = 9e-09
Identities = 34/89 (38%), Positives = 42/89 (47%), Gaps = 12/89 (13%)
Query: 290 HHSPCK-----NGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS-----NPCRNGGSC 339
H SPC NG TC SG Y C C G+ G C +S CD + C G +C
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATC 2668
Query: 340 KDQEDGYHCLCPPGYYGLHCEHSTLSCAD 368
GY C CP G G++CE + LS +D
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYCEQA-LSISD 2696
Score = 54.7 bits (130), Expect = 3e-07
Identities = 32/75 (42%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 262 GTC---STPWQCTCDEGWGGLFCDQDLNYC-THHSP---CKNGATCSNSGQRSYTCTCRP 314
GTC T C C GW G FC + ++ C H P C GATC S YTC C
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI-SLPHGYTCFCPL 2681
Query: 315 GYTGVDCELELSECD 329
G TG+ CE LS D
Sbjct: 2682 GTTGIYCEQALSISD 2696
Score = 53.9 bits (128), Expect = 5e-07
Identities = 27/82 (32%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 396 GSNCEK-KVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGT 454
G N E V C + C N G C++ + C C ++G C+ + C NPC +G T
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGAT 2385
Query: 455 CHDLE-NGLMCTCPAGFSGRRC 475
C ++C CP G SG C
Sbjct: 2386 CVPKSGTDIVCLCPYGRSGPLC 2407
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C + CRN G+C + C CP Y G C+ + SC ++PC NG +C ++ G +
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPKS-GTDIV 2395
Query: 388 CECPPNFTGSNCEKKVD 404
C CP +G C ++
Sbjct: 2396 CLCPYGRSGPLCTDAIN 2412
Score = 53.5 bits (127), Expect = 6e-07
Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C N CRNGG C + C C P + G C S +SC ++ C + C +Q +Y+
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS-VSCLNNLCLHQSLCIP-DQSFSYS 2936
Query: 388 CECPPNFTGSNCEKKVDRCTSNPCAN 413
C C + G CE K T+ N
Sbjct: 2937 CLCTLGWVGRYCENKTSFSTAKFMGN 2962
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/74 (35%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 287 YCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQE-DG 345
+C HH C+N TC + + + C C Y+G C+ + C++NPC NG +C +
Sbjct: 2338 WCAHHL-CRNNGTCISDNENLF-CECPRLYSGKLCQF--ASCENNPCGNGATCVPKSGTD 2393
Query: 346 YHCLCPPGYYGLHC 359
CLCP G G C
Sbjct: 2394 IVCLCPYGRSGPLC 2407
Score = 49.7 bits (117), Expect = 9e-06
Identities = 30/94 (31%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Query: 438 ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRC-EVRTSIDACASSP--CFNRAT 494
+ H S C+ C +GGTC + + C C G+ G C E ++ D P C AT
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 495 CYTDLSTDTFVCNCPYGFVGSRCEFPVGL-PPSF 527
C + + C CP G G CE + + PSF
Sbjct: 2668 CIS--LPHGYTCFCPLGTTGIYCEQALSISDPSF 2699
Score = 49.3 bits (116), Expect = 1e-05
Identities = 27/81 (33%), Positives = 35/81 (43%), Gaps = 7/81 (8%)
Query: 326 SECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC---ADSP--CFNGGSCRER 380
S C C NGG+C + +C C G+ G C + +C D P C G +C
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL 2671
Query: 381 NQGANYACECPPNFTGSNCEK 401
G Y C CP TG CE+
Sbjct: 2672 PHG--YTCFCPLGTTGIYCEQ 2690
Score = 45.1 bits (105), Expect = 2e-04
Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 444 CARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDT 503
C N C +GG C C C ++G C S C ++ C +++ C D S +
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS---CLNNLCLHQSLCIPDQSF-S 2934
Query: 504 FVCNCPYGFVGSRCE 518
+ C C G+VG CE
Sbjct: 2935 YSCLCTLGWVGRYCE 2949
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 7/58 (12%)
Query: 239 CLCRPGWQGRLCNECIP--HNGCRHGTCSTP-----WQCTCDEGWGGLFCDQDLNYCT 289
C C P W G CN+ + +N C H + P + C C GW G +C+ ++ T
Sbjct: 2899 CRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFST 2956
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 14/79 (17%)
Query: 256 HNGCRHG-TCS---TPWQCTCDEGWGGLFCDQDL----NYCTHHSPCKNGATCSNSGQRS 307
+N CR+G C+ T + C C W G C+Q + N C H S C S
Sbjct: 2881 YNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQS------LCIPDQSFS 2934
Query: 308 YTCTCRPGYTGVDCELELS 326
Y+C C G+ G CE + S
Sbjct: 2935 YSCLCTLGWVGRYCENKTS 2953
Score = 40.0 bits (92), Expect = 0.007
Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 19/120 (15%)
Query: 184 CSRLCKKRNDHFGHY--VCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAE--- 238
C + R + GH+ + P+G+ + G+ P L C G C +
Sbjct: 2576 CIFTLQVRTEKDGHFRGLGNPEGHPNAGRS-VGQCHASPCSLMKCGN-GGTCIESGTSVY 2633
Query: 239 CLCRPGWQGRLCNECI---------PHNGCRHGTC-STP--WQCTCDEGWGGLFCDQDLN 286
C C GW+G C E + PH+ R TC S P + C C G G++C+Q L+
Sbjct: 2634 CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS 2693
Score = 39.3 bits (90), Expect = 0.012
Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 10/69 (14%)
Query: 442 SDCARNPCAHGGTCHD--LENGLM---CTCPAGFSGRRCEVRTSIDACASSPCFNRATCY 496
S C ++ C +GGTCH L +G++ C CP F+GR CE DA P FN Y
Sbjct: 2101 SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK----DAGLFFPSFN-GNSY 2155
Query: 497 TDLSTDTFV 505
+L FV
Sbjct: 2156 LELPFLKFV 2164
Score = 38.5 bits (88), Expect = 0.021
Identities = 19/48 (39%), Positives = 21/48 (43%), Gaps = 5/48 (10%)
Query: 208 CLPGWTGEYCQQPI-CLSGCHEQNGYC----SKPAECLCRPGWQGRLC 250
CLP W G C Q + CL+ C S CLC GW GR C
Sbjct: 2901 CLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 36.2 bits (82), Expect = 0.10
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 5/56 (8%)
Query: 366 CADSPCFNGGSCRE---RNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418
C C NGG+C + ++ C+CP +FTG CEK D P NG L
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK--DAGLFFPSFNGNSYL 2156
Score = 35.8 bits (81), Expect = 0.14
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 7/70 (10%)
Query: 256 HNGCRH-GTCSTPWQ---CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 311
H+ CR+ GTC + + C C + G C C ++PC NGATC C
Sbjct: 2341 HHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASC-ENNPCGNGATCVPKSGTDIVCL 2397
Query: 312 CRPGYTGVDC 321
C G +G C
Sbjct: 2398 CPYGRSGPLC 2407
Score = 32.7 bits (73), Expect = 1.1
Identities = 18/48 (37%), Positives = 22/48 (45%), Gaps = 4/48 (8%)
Query: 484 CASSPCFNRATCYTDLSTD---TFVCNCPYGFVGSRCEFPVGL-PPSF 527
C C N TC+ + +F C+CP F G CE GL PSF
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSF 2150
Score = 31.2 bits (69), Expect = 3.3
Identities = 13/36 (36%), Positives = 17/36 (47%), Gaps = 2/36 (5%)
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF 519
CA C N TC +D + C CP + G C+F
Sbjct: 2339 CAHHLCRNNGTCISD--NENLFCECPRLYSGKLCQF 2372
Score = 30.8 bits (68), Expect = 4.3
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 150 AVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHY-VCQPDGNLS- 207
A G N + T+ +S R C ++ G+ C++ N+ H +C PD + S
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCR--CLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSY 2935
Query: 208 ---CLPGWTGEYCQQPICLS 224
C GW G YC+ S
Sbjct: 2936 SCLCTLGWVGRYCENKTSFS 2955
Score = 30.4 bits (67), Expect = 5.7
Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 7/59 (11%)
Query: 326 SECDSNPCRNGGSC-----KDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE 379
S C + C NGG+C + C CP + G CE + P FNG S E
Sbjct: 2101 SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD--AGLFFPSFNGNSYLE 2157
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 239 bits (611), Expect = 5e-63
Identities = 145/417 (34%), Positives = 197/417 (47%), Gaps = 81/417 (19%)
Query: 174 ICSDNYYGDNCSR--------LC---KKRNDHFGHYVCQPDGNLSCLPGWTGEYCQ-QPI 221
+C + + G++CS+ +C +D + C +C G TG C
Sbjct: 301 VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYC------ACPMGKTGLLCHLDDA 354
Query: 222 CLSG-CHEQNGYCSKP----AECLCRPGWQGRLCN----EC-IPHNGCRH-GTCSTP--- 267
C+S CHE + P A C C PG+ G C+ EC I N C H G C
Sbjct: 355 CVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGS 414
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNS-GQRSYTCTCRPGYTGVDCELELS 326
+ C C G+ G C+ D+N C PC+N ATC + GQ +TC C G+TG CE+++
Sbjct: 415 FLCQCGRGYTGPRCETDVNECLS-GPCRNQATCLDRIGQ--FTCICMAGFTGTYCEVDID 471
Query: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQG--- 383
EC S+PC NGG CKD+ +G+ C CP G+ G C+ CA +PC NG C ++ G
Sbjct: 472 ECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYEC 531
Query: 384 --------------------------------ANYACECPPNFTGSNCEKKVDRCTSNPC 411
A+++C C P +TG+ CE +VD C S PC
Sbjct: 532 RCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPC 591
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFS 471
+GG+CL+ +CRC G TG CE+++ DCA NPC G C D N C C GF+
Sbjct: 592 RHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF-GVCRDGINRYDCVCQPGFT 650
Query: 472 GRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
G C V I+ CASSPC +C + F C CP G + C LPPS P
Sbjct: 651 GPLCNV--EINECASSPCGEGGSCVD--GENGFRCLCPPGSLPPLC-----LPPSHP 698
Score = 236 bits (603), Expect = 4e-62
Identities = 127/330 (38%), Positives = 161/330 (48%), Gaps = 26/330 (7%)
Query: 208 CLPGWTGEYCQ-QPICLSGCHEQNGYCSKPA-------ECLCRPGWQGRLCNECIP--HN 257
C PGW GE CQ + C SG G C C C G++G C+ P +
Sbjct: 67 CPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSS 126
Query: 258 GCRHGT-CST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTC 312
C HG CS + C+C G+ G C D++ C PC++G TC N+ S+ C C
Sbjct: 127 PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-PGSFRCQC 185
Query: 313 RPGYTGVDCELELSECDSNPCRNGGSCKDQED-GYHCLCPPGYYGLHCEHSTLSCADSPC 371
GYTG CE C +PCRNGG+C+ D Y C C PG+ G +CE + C C
Sbjct: 186 PAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRC 245
Query: 372 FNGGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNP--CANGGQCLNRGPSRMCRC 428
NGG+C + G N Y C+CPP +TG C + VD C P C NGG C N C C
Sbjct: 246 LNGGTCVD---GVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC 302
Query: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSP 488
G+TG C ++ DCA C HG TCHD C CP G +G C + DAC S+P
Sbjct: 303 VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLD---DACVSNP 359
Query: 489 CFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C A C T+ +C CP GF G C+
Sbjct: 360 CHEDAICDTNPVNGRAICTCPPGFTGGACD 389
Score = 232 bits (591), Expect = 1e-60
Identities = 143/420 (34%), Positives = 190/420 (45%), Gaps = 90/420 (21%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDG---------NLSCLPGWTGEYCQQPI---- 221
C + G C + ++ G C P G + +C G+TG C Q I
Sbjct: 798 CPQGWQGPRCQQ---DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
Query: 222 ---CLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPHNGCRHGTCS---TPWQCT 271
CL+G Q+G S C C PG+ G C +EC+ N C GTC+ + CT
Sbjct: 855 PNPCLNGGSCQDGVGS--FSCSCLPGFAGPRCARDVDECLS-NPCGPGTCTDHVASFTCT 911
Query: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
C G+GG C+QDL C+ S C NG TC + G S++C CRPGYTG C+ E C S
Sbjct: 912 CPPGYGGFHCEQDLPDCSPSS-CFNGGTCVD-GVNSFSCLCRPGYTGAHCQHEADPCLSR 969
Query: 332 PCRNGGSCKDQEDGY------------------------------------HCLCPPGYY 355
PC +GG C G+ +CLCPPG+
Sbjct: 970 PCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWS 1029
Query: 356 GLHCEHSTLSCADSP----------CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDR 405
G C+ +L C ++ C GG C + + +++ C CP TGS+CE++VD
Sbjct: 1030 GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDED--SSHYCVCPEGRTGSHCEQEVDP 1087
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCT 465
C + PC +GG C MC C PG+ G CE V +CA PC HGG+C DL +C+
Sbjct: 1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147
Query: 466 CPAGFSGRRCEVRTSIDACASSP-------CFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
CP G G CE+ D C P C + TC DL F C CP G+ G RCE
Sbjct: 1148 CPPGTLGVLCEINE--DDCGPGPPLDSGPRCLHNGTC-VDL-VGGFRCTCPPGYTGLRCE 1203
Score = 230 bits (586), Expect = 4e-60
Identities = 124/377 (32%), Positives = 173/377 (45%), Gaps = 66/377 (17%)
Query: 196 GHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGCHEQNGYCSKPAE----CLCRPGWQGRL 249
G + CQ C G+TG C+ P C G C + + C C PG++G+
Sbjct: 179 GSFRCQ------CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN 232
Query: 250 C----NECIPHNGCRHGTCS---TPWQCTCDEGWGGLFCDQDLNYCT-HHSPCKNGATCS 301
C ++C H GTC + C C W G FC +D++ C + C NG TC
Sbjct: 233 CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCF 292
Query: 302 NSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEH 361
N+ ++C C G+TG C + +C + C +G +C D+ ++C CP G GL C H
Sbjct: 293 NT-LGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLC-H 350
Query: 362 STLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT--SNPCANGGQCLN 419
+C +PC C C CPP FTG C++ VD C+ +NPC + G+C+N
Sbjct: 351 LDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVN 410
Query: 420 R--------------------------GPSR------------MCRCRPGFTGTYCELHV 441
GP R C C GFTGTYCE+ +
Sbjct: 411 TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDI 470
Query: 442 SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLST 501
+C +PC +GG C D NG CTCP+GFSG C++ +D CAS+PC N A C
Sbjct: 471 DECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL--DVDECASTPCRNGAKCVD--QP 526
Query: 502 DTFVCNCPYGFVGSRCE 518
D + C C GF G+ C+
Sbjct: 527 DGYECRCAEGFEGTLCD 543
Score = 222 bits (566), Expect = 8e-58
Identities = 120/316 (37%), Positives = 159/316 (50%), Gaps = 25/316 (7%)
Query: 220 PICLSGCHEQNG-----YCSKPAECLCRPGWQGRLCNECIP-HNG--CRHGTCSTP---- 267
P CL G NG S+ A CLC PGW G C P H+G G C +
Sbjct: 41 PPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG 100
Query: 268 ---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324
+ C C G+ G C + C SPC +GA CS + C+C PGY G C +
Sbjct: 101 TARFSCRCPRGFRGPDCSLP-DPCLS-SPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158
Query: 325 LSECD-SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQG 383
+ EC PCR+GG+C + + C CP GY G CE+ + CA SPC NGG+CR+
Sbjct: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD- 217
Query: 384 ANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD 443
Y C C P F G NCE VD C + C NGG C++ + C+C P +TG +C V +
Sbjct: 218 LTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDE 277
Query: 444 CARNP--CAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLST 501
C P C +GGTC + G C C G++G C +ID CA++ CF+ ATC+ ++
Sbjct: 278 CQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCS--QNIDDCATAVCFHGATCHDRVA- 334
Query: 502 DTFVCNCPYGFVGSRC 517
+F C CP G G C
Sbjct: 335 -SFYCACPMGKTGLLC 349
Score = 221 bits (563), Expect = 2e-57
Identities = 128/379 (33%), Positives = 174/379 (45%), Gaps = 63/379 (16%)
Query: 208 CLPGWTGEYCQQPI-CLSGCHEQNGYCSKPAE----CLCRPGWQGRLC----NECIPHNG 258
C G+ G C P CLS CS + C C PG+QGR C +EC
Sbjct: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
Query: 259 CRHG-TC-STP--WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRP 314
CRHG TC +TP ++C C G+ G C+ C SPC+NG TC SG +Y C C P
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAP-SPCRNGGTCRQSGDLTYDCACLP 226
Query: 315 GYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--CF 372
G+ G +CE+ + +C + C NGG+C D + Y+C CPP + G C C P C
Sbjct: 227 GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH 286
Query: 373 NGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPS--------- 423
NGG+C N ++C C +TG +C + +D C + C +G C +R S
Sbjct: 287 NGGTCF--NTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGK 344
Query: 424 ------------------------------RMCRCRPGFTGTYCELHVSDCA--RNPCAH 451
+C C PGFTG C+ V +C+ NPC H
Sbjct: 345 TGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEH 404
Query: 452 GGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYG 511
G C + + +C C G++G RCE T ++ C S PC N+ATC + F C C G
Sbjct: 405 LGRCVNTQGSFLCQCGRGYTGPRCE--TDVNECLSGPCRNQATCLDRIGQ--FTCICMAG 460
Query: 512 FVGSRCEFPVGLPPSFPWV 530
F G+ CE + S P V
Sbjct: 461 FTGTYCEVDIDECQSSPCV 479
Score = 209 bits (531), Expect = 9e-54
Identities = 129/405 (31%), Positives = 172/405 (42%), Gaps = 68/405 (16%)
Query: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDG----NLSCLPGWTGEYCQQPI-- 221
Y C++ + G C R C H G V DG + +C PG+TG C+ +
Sbjct: 529 YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCV---DGIASFSCACAPGYTGTRCESQVDE 585
Query: 222 CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNECIPH---NGCRHGTCS---TPWQCTC 272
C S G C + C C G G C I N C G C + C C
Sbjct: 586 CRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVC 645
Query: 273 DEGWGGLFCDQDLNYCTHHSPCKNGATC--SNSGQR------------------------ 306
G+ G C+ ++N C SPC G +C +G R
Sbjct: 646 QPGFTGPLCNVEINECAS-SPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC 704
Query: 307 ----------SYTCTCRPGYTGVDCELELSE--CDSNPCRNGGSCKDQEDGYHCLCPPGY 354
+ C C PG++G C L+ C+S PCR GG+C G+HC CPPG
Sbjct: 705 SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGV 764
Query: 355 YGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSN-PCAN 413
G CE + C +PC +GG C E G C CP + G C++ VD C PC
Sbjct: 765 QGRQCELLS-PCTPNPCEHGGRC-ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGP 822
Query: 414 GGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGR 473
G C N S C C G+TG C+ ++DC NPC +GG+C D C+C GF+G
Sbjct: 823 HGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGP 882
Query: 474 RCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
RC +D C S+PC TC ++ +F C CP G+ G CE
Sbjct: 883 RC--ARDVDECLSNPC-GPGTCTDHVA--SFTCTCPPGYGGFHCE 922
Score = 206 bits (523), Expect = 8e-53
Identities = 121/338 (35%), Positives = 163/338 (48%), Gaps = 31/338 (9%)
Query: 199 VCQPDG-NLSCLPGWTGEYCQQPI---CLSGCHEQNGYCSKPA---ECLCRPGWQGRLCN 251
V QPDG C G+ G C + + CH +G C C C PG+ G C
Sbjct: 523 VDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH--HGRCVDGIASFSCACAPGYTGTRCE 580
Query: 252 ECIPH---NGCRHG----TCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
+ CRHG + C C G G+ C+ +++ C + PC G G
Sbjct: 581 SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN-PCTFGVC--RDG 637
Query: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
Y C C+PG+TG C +E++EC S+PC GGSC D E+G+ CLCPPG C +
Sbjct: 638 INRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSH 697
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV--DRCTSNPCANGGQCLNRGP 422
CA PC + G C + G + C C P ++G C + + D C S PC GG C + G
Sbjct: 698 PCAHEPC-SHGICYDAPGG--FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM 754
Query: 423 SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGL-MCTCPAGFSGRRCEVRTSI 481
C C PG G CEL +S C NPC HGG C L +C+CP G+ G RC+ +
Sbjct: 755 GFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ--QDV 811
Query: 482 DACAS-SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
D CA +PC C T+L+ +F C C G+ G C+
Sbjct: 812 DECAGPAPCGPHGIC-TNLA-GSFSCTCHGGYTGPSCD 847
Score = 202 bits (515), Expect = 6e-52
Identities = 136/477 (28%), Positives = 178/477 (37%), Gaps = 135/477 (28%)
Query: 170 SYRVICSDNYYGDNCSR---LCKKR-------NDHFGHYVCQPDGNLSCLPGWTGEYCQQ 219
S+ C + G C+R C DH + C +C PG+ G +C+Q
Sbjct: 870 SFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTC------TCPPGYGGFHCEQ 923
Query: 220 --PICLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIPHNGCRHGTCSTP--- 267
P C G C CLCRPG+ G C C+ G CS
Sbjct: 924 DLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPG 983
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
++CTC E + G C +++C+ PC+NG C +G C C PG++G C++
Sbjct: 984 FRCTCLESFTGPQCQTLVDWCSRQ-PCQNGGRCVQTGAY---CLCPPGWSGRLCDIRSLP 1039
Query: 328 CDSNP----------CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSC 377
C C+ GG C D++ ++C+CP G G HCE C PC +GG+C
Sbjct: 1040 CREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099
Query: 378 RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYC 437
R G Y CEC P + G NCE VD C S PC +GG C++ +C C PG G C
Sbjct: 1100 RGYMGG--YMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLC 1157
Query: 438 ELHVSDCARNP-------CAHGGTCHDLENGLMCTCP----------------------- 467
E++ DC P C H GTC DL G CTCP
Sbjct: 1158 EINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAA 1217
Query: 468 ------------------AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTD---TFVC 506
AGFSG RC+ T + C S PC + C TF C
Sbjct: 1218 HTRDCLQDPGGGFRCLCHAGFSGPRCQ--TVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275
Query: 507 NC--------------------------------------PYGFVGSRCEFPVGLPP 525
+C P G G C G PP
Sbjct: 1276 HCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPP 1332
Score = 195 bits (496), Expect = 1e-49
Identities = 133/439 (30%), Positives = 171/439 (38%), Gaps = 88/439 (20%)
Query: 170 SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQ---PDGNLSCLPGWTGEYCQQPI-- 221
S+ +C Y G +C C R G VC P +CL +TG CQ +
Sbjct: 945 SFSCLCRPGYTGAHCQHEADPCLSRPCLHGG-VCSAAHPGFRCTCLESFTGPQCQTLVDW 1003
Query: 222 CLSGCHEQNGYCSKP-AECLCRPGWQGRLCN-------ECIPHNGCR-------HGTC-- 264
C + G C + A CLC PGW GRLC+ E G R G C
Sbjct: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD 1063
Query: 265 -STPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
+ C C EG G C+Q+++ C PC++G TC Y C C PGY G +CE
Sbjct: 1064 EDSSHYCVCPEGRTGSHCEQEVDPCLAQ-PCQHGGTCRGY-MGGYMCECLPGYNGDNCED 1121
Query: 324 ELSECDSNPCRNGGSCKD--------------------QED------------------- 344
++ EC S PC++GGSC D ED
Sbjct: 1122 DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGT 1181
Query: 345 ------GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE--RNQGANYACECPPNFTG 396
G+ C CPPGY GL CE C C + R+ ++ G + C C F+G
Sbjct: 1182 CVDLVGGFRCTCPPGYTGLRCEADINECRSGAC-HAAHTRDCLQDPGGGFRCLCHAGFSG 1240
Query: 397 SNCEKKVDRCTSNPCANGGQCL-----NRGPSRMCRCRPGFTGTYCELHVSDCARNPCAH 451
C+ + C S PC +GGQC G + C C F G CE C C
Sbjct: 1241 PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPV 1300
Query: 452 GGTCHDLENGLMCTCPAGFSGRRCE------VRTSIDACASSPCFNRATCYTDLSTDTFV 505
G C G C CP G SG C S +CA++PC + +C F
Sbjct: 1301 GVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR 1360
Query: 506 CNCPYGFVGSRCEFPVGLP 524
C C G+ G RCE P P
Sbjct: 1361 CACAQGWTGPRCEAPAAAP 1379
Score = 113 bits (283), Expect = 5e-25
Identities = 65/162 (40%), Positives = 82/162 (50%), Gaps = 14/162 (8%)
Query: 366 CAD-SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR---G 421
C D SPC NGG C + AC CPP + G C+ + D C S PCA G C + G
Sbjct: 43 CLDGSPCANGGRCTQL-PSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAG 100
Query: 422 PSRM-CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENG-LMCTCPAGFSGRRCEVRT 479
+R CRC GF G C L C +PCAHG C +G +C+CP G+ GR C R+
Sbjct: 101 TARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSC--RS 157
Query: 480 SIDAC-ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520
+D C PC + TC + +F C CP G+ G CE P
Sbjct: 158 DVDECRVGEPCRHGGTCLN--TPGSFRCQCPAGYTGPLCENP 197
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 236 bits (601), Expect = 7e-62
Identities = 130/371 (35%), Positives = 177/371 (47%), Gaps = 36/371 (9%)
Query: 170 SYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLS---------CLPGWTGEYCQQP 220
+Y +C + + G +CS + G C+ G C+ GW G C++
Sbjct: 297 TYTCLCPETWTGWDCSEDVDECETQ-GPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEEN 355
Query: 221 I--CLSGCHEQNGYCSKPA---ECLCRPGWQGRLCN---ECIPHNGCRHGTCST-----P 267
+ C++ C CLC PG G LC+ C+ CST
Sbjct: 356 LDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGS 415
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHH----SPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
C C G+ G C QDL+ C SPC++G +C N+ S+ C C PGYTG CE
Sbjct: 416 TLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNT-PGSFNCLCPPGYTGSRCEA 474
Query: 324 ELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQG 383
+ +EC S PC G +C D +HCLCPPG G CE T CA +PC N C + G
Sbjct: 475 DHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNG 534
Query: 384 ANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD 443
+ C C P F+G+ CE+ +D C S+PCANGGQC ++ + C+C PGF G C+ V +
Sbjct: 535 --FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDE 592
Query: 444 CARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDT 503
C +PC G +C DL C CP+GF+G+ CEV CA + C + C D
Sbjct: 593 CLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEV----PLCAPNLCQPKQICKD--QKDK 646
Query: 504 FVCNCPYGFVG 514
C CP G G
Sbjct: 647 ANCLCPDGSPG 657
Score = 227 bits (579), Expect = 2e-59
Identities = 128/402 (31%), Positives = 158/402 (39%), Gaps = 103/402 (25%)
Query: 208 CLPGWTGEYCQQPICLSGCHEQNGYCSKP---AECLCRPGWQGRLCNECIPHNG---CRH 261
C G+TG+ C+ P+C + C A CLC G G C P C H
Sbjct: 615 CPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG-----CAPPEDNCTCHH 669
Query: 262 GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDC 321
G C C CD GW G C+ +L C +PC +G TC Y CTC GYTG C
Sbjct: 670 GHCQRS-SCVCDVGWTGPECEAELGGCIS-APCAHGGTCYPQPS-GYNCTCPTGYTGPTC 726
Query: 322 ELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRER- 380
E++ C S PC NGGSC GY+C CPP + G C+ ST C +PCFNGG+C R
Sbjct: 727 SEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRP 786
Query: 381 ------------------------------------NQGANYACECPPNFTGSNCEKKVD 404
+ C CP +TG +C+ +D
Sbjct: 787 GTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMD 846
Query: 405 RCTSNPCANGGQCLNRGPSRMCRC------------------------------------ 428
C PC CL GPS C C
Sbjct: 847 LCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906
Query: 429 ------------RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
PGF G+ C+ HV+ C PC +G TC +G +C C G+ G+ C
Sbjct: 907 CVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCS 966
Query: 477 VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
+DAC S PC N TC F C CP GFVG RCE
Sbjct: 967 --KELDACQSQPCHNHGTCTP--KPGGFHCACPPGFVGLRCE 1004
Score = 224 bits (571), Expect = 2e-58
Identities = 168/539 (31%), Positives = 218/539 (40%), Gaps = 84/539 (15%)
Query: 37 FINERG---VLASGRP---CEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVL------ 84
F ++RG + ASGRP C PG T + L+ F S PC G V
Sbjct: 126 FCSKRGRCHIQASGRPQCSCMPGW-TGEQCQLRDF---CSANPCVNGGVCLATYPQIQCH 181
Query: 85 ---GTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFS----LIIEAWHAPGDDLRPEALPPD 137
G A D + ++P P + T L P +LR PP
Sbjct: 182 CPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPP- 240
Query: 138 ALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGH 197
+G G L+ E+ ST + +C + G +C + D+
Sbjct: 241 --------RGCSNGGTCQLMPEKDSTF------HLCLCPPGFIGPDC----EVNPDNCVS 282
Query: 198 YVCQPDGNLS---------CLPGWTGEYCQQPICLSGCHEQN-------GYCSKPA---E 238
+ CQ G C WTG C + + C Q G C A
Sbjct: 283 HQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDV--DECETQGPPHCRNGGTCQNSAGSFH 340
Query: 239 CLCRPGWQGRLCNE----CIPHNGCRHGTCST---PWQCTCDEGWGGLFCDQDLNYCTHH 291
C+C GW G C E CI TC + C C G GL C + + C
Sbjct: 341 CVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQ 399
Query: 292 SPCKNGATCSNSGQRSYT-CTCRPGYTGVDCELELSEC-----DSNPCRNGGSCKDQEDG 345
PC A CS + T C C+PGY+G C +L EC +PC +GGSC +
Sbjct: 400 -PCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGS 458
Query: 346 YHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDR 405
++CLCPPGY G CE C PC G +C + A + C CPP G CE + +
Sbjct: 459 FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLL--ATFHCLCPPGLEGQLCEVETNE 516
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCT 465
C S PC N C + C C PGF+GT CE + +C +PCA+GG C D C
Sbjct: 517 CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCK 576
Query: 466 CPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524
C GF G RC+ T +D C S PC A+C DL F C CP GF G CE P+ P
Sbjct: 577 CLPGFEGPRCQ--TEVDECLSDPCPVGASCL-DLP-GAFFCLCPSGFTGQLCEVPLCAP 631
Score = 211 bits (537), Expect = 2e-54
Identities = 117/344 (34%), Positives = 150/344 (43%), Gaps = 33/344 (9%)
Query: 208 CLPGWTGEYCQ--QPICLSGCHEQNGYCSKPA---ECLCRPGWQGRLCN----------- 251
C G+TG CQ +C +N +C + CLC GW G LCN
Sbjct: 832 CPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAAL 891
Query: 252 ------ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ 305
+ HNG + C C G+ G C +N C PC+NGATC +
Sbjct: 892 SQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESR-PCQNGATCM-AQP 949
Query: 306 RSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLS 365
Y C C PGY G +C EL C S PC N G+C + G+HC CPPG+ GL CE
Sbjct: 950 SGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDE 1009
Query: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM 425
C D PC G+ + + C+C P TG CE ++D C S PC +GG C S +
Sbjct: 1010 CLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPL 1069
Query: 426 ---CRCRPGFTGTYCELHVSDCARNPCAHGGTC-HDLENGL--MCTCPAGFSGRRCEVRT 479
C C GF G C C + C HGG C + G C C +G+ G C
Sbjct: 1070 GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPP 1129
Query: 480 SIDACA-SSPCFNRATC--YTDLSTDTFVCNCPYGFVGSRCEFP 520
+ C SPC +C T L F C+CP+ G RC+ P
Sbjct: 1130 APKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKP 1173
Score = 207 bits (526), Expect = 3e-53
Identities = 131/414 (31%), Positives = 170/414 (41%), Gaps = 82/414 (19%)
Query: 174 ICSDNYYG-----DNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGC 226
+C D G DNC+ C H GH CQ + C GWTG C+ + C+S
Sbjct: 650 LCPDGSPGCAPPEDNCT--C-----HHGH--CQRSSCV-CDVGWTGPECEAELGGCISAP 699
Query: 227 HEQNGYC-SKPA--ECLCRPGWQGRLCNECIP--HNG-CRHGTCSTP----WQCTCDEGW 276
G C +P+ C C G+ G C+E + H+G C +G P + CTC
Sbjct: 700 CAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH 759
Query: 277 GGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS-ECDSNPCRN 335
G C +YC +PC NG TC N +++C C G+ G CE +L C +PCRN
Sbjct: 760 TGPQCQTSTDYCVS-APCFNGGTCVNR-PGTFSCLCAMGFQGPRCEGKLRPSCADSPCRN 817
Query: 336 GGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPC------------------------ 371
+C+D G CLCP GY G C+ CA PC
Sbjct: 818 RATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGP 877
Query: 372 ------------------------FNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT 407
NGG C + G +Y C CPP F GS C+ V+ C
Sbjct: 878 LCNLPLSSCQKAALSQGIDVSSLCHNGGLCVD--SGPSYFCHCPPGFQGSLCQDHVNPCE 935
Query: 408 SNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCP 467
S PC NG C+ + +C+C PG+ G C + C PC + GTC G C CP
Sbjct: 936 SRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACP 995
Query: 468 AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
GF G RCE +D C PC T + F C C G G CE +
Sbjct: 996 PGFVGLRCE--GDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEI 1047
Score = 206 bits (524), Expect = 6e-53
Identities = 133/431 (30%), Positives = 181/431 (41%), Gaps = 85/431 (19%)
Query: 162 STLTRLRYSYRVICSDNYYGDNCSR---------LCKKRNDHFGHYVCQPDGN--LSCLP 210
S+ + L S+ C + G+ C C KR G Q G SC+P
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKR----GRCHIQASGRPQCSCMP 147
Query: 211 GWTGEYCQ-QPICLSGCHEQNGYCSKP---AECLCRPGWQGRLC----NECIPHNG-CRH 261
GWTGE CQ + C + G C +C C PG++G C NEC G C
Sbjct: 148 GWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPK 207
Query: 262 GT-CSTP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYT---CTCRP 314
GT C +QC C G G C+ C C NG TC ++ T C C P
Sbjct: 208 GTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG-CSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 315 GYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC---ADSPC 371
G+ G DCE+ C S+ C+NGG+C+D D Y CLCP + G C C C
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHC 326
Query: 372 FNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR----------- 420
NGG+C +N ++ C C + G++CE+ +D C + CA G C++R
Sbjct: 327 RNGGTC--QNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384
Query: 421 ----------------------------GPSRMCRCRPGFTGTYCELHVSDC-----ARN 447
S +C C+PG++G C + +C +
Sbjct: 385 RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPS 444
Query: 448 PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCN 507
PC HGG+C + C CP G++G RCE + C S PC +TC L+ TF C
Sbjct: 445 PCEHGGSCLNTPGSFNCLCPPGYTGSRCE--ADHNECLSQPCHPGSTCLDLLA--TFHCL 500
Query: 508 CPYGFVGSRCE 518
CP G G CE
Sbjct: 501 CPPGLEGQLCE 511
Score = 200 bits (508), Expect = 4e-51
Identities = 124/387 (32%), Positives = 162/387 (41%), Gaps = 79/387 (20%)
Query: 204 GNLSCLPGWTGEYCQQP--------------------------------------ICLSG 225
G C PG+ GE CQ P CL G
Sbjct: 49 GTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPG 108
Query: 226 -----CHEQ------NGYCSKPA----------ECLCRPGWQGRLC---NECIPHNGCRH 261
C + +CSK +C C PGW G C + C +
Sbjct: 109 FTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNG 168
Query: 262 GTCSTPW---QCTCDEGWGGLFCDQDLNYCTHH-SPCKNGATCSNSGQRSYTCTCRPGYT 317
G C + QC C G+ G C++D+N C PC G +C N+ S+ C C G
Sbjct: 169 GVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNT-LGSFQCLCPVGQE 227
Query: 318 GVDCELELSECDSNPCRNGGSCK---DQEDGYH-CLCPPGYYGLHCEHSTLSCADSPCFN 373
G CEL C C NGG+C+ +++ +H CLCPPG+ G CE + +C C N
Sbjct: 228 GPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQN 287
Query: 374 GGSCRERNQGANYACECPPNFTGSNCEKKVDRC-TSNP--CANGGQCLNRGPSRMCRCRP 430
GG+C++ Y C CP +TG +C + VD C T P C NGG C N S C C
Sbjct: 288 GGTCQDGLD--TYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVS 345
Query: 431 GFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCF 490
G+ GT CE ++ DC CA G TC D C CP G +G C + D C S PC
Sbjct: 346 GWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE---DMCLSQPCH 402
Query: 491 NRATCYTDLSTDTFVCNCPYGFVGSRC 517
A C T+ T + +C C G+ G C
Sbjct: 403 GDAQCSTNPLTGSTLCLCQPGYSGPTC 429
Score = 159 bits (402), Expect = 8e-39
Identities = 86/245 (35%), Positives = 112/245 (45%), Gaps = 23/245 (9%)
Query: 293 PCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCK------------ 340
PC NG TC + TC C PG+ G C+ ++ C+NGGSC+
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 341 --DQEDGYHCLCPPGYYGLHCEHSTLS-CADSPCFNGGSCRERNQGANYACECPPNFTGS 397
+ C C PG+ G C+ C S C G C + G C C P +TG
Sbjct: 94 PSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASG-RPQCSCMPGWTGE 152
Query: 398 NCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARN--PCAHGGTC 455
C+ + D C++NPC NGG CL P C C PGF G CE V++C ++ PC G +C
Sbjct: 153 QCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSC 211
Query: 456 HDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDT--FVCNCPYGFV 513
H+ C CP G G RCE+R C C N TC D+ +C CP GF+
Sbjct: 212 HNTLGSFQCLCPVGQEGPRCELRAG--PCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFI 269
Query: 514 GSRCE 518
G CE
Sbjct: 270 GPDCE 274
Score = 123 bits (308), Expect = 6e-28
Identities = 72/211 (34%), Positives = 94/211 (44%), Gaps = 22/211 (10%)
Query: 332 PCRNGGSCKDQEDGYH-CLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGA------ 384
PC NGG+C G C C PG+ G C+ C NGGSC+
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 385 ------NYACECPPNFTGSNCEKKV-DRCTSNPCANGGQCLNRGPSR-MCRCRPGFTGTY 436
++ C C P FTG C+ K+ D C + C+ G+C + R C C PG+TG
Sbjct: 94 PSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQ 153
Query: 437 CELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSP--CFNRAT 494
C+L C+ NPC +GG C + C CP GF G CE ++ C P C +
Sbjct: 154 CQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACE--RDVNECFQDPGPCPKGTS 210
Query: 495 CYTDLSTDTFVCNCPYGFVGSRCEFPVGLPP 525
C+ L + F C CP G G RCE G P
Sbjct: 211 CHNTLGS--FQCLCPVGQEGPRCELRAGPCP 239
Score = 95.5 bits (236), Expect = 1e-19
Identities = 106/406 (26%), Positives = 147/406 (36%), Gaps = 86/406 (21%)
Query: 171 YRVICSDNYYGDNCSR---LCKKRNDHFGHYVCQPDG---NLSCLPGWTGEYCQQPICLS 224
Y C+ Y G NCS+ C+ + H H C P + +C PG+ G C+ +
Sbjct: 952 YLCQCAPGYDGQNCSKELDACQSQPCH-NHGTCTPKPGGFHCACPPGFVGLRCEGDV--- 1007
Query: 225 GCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQD 284
ECL +P C P + + + C C G G +C+ +
Sbjct: 1008 ------------DECLDQP---------CHPTGTAACHSLANAFYCQCLPGHTGQWCEVE 1046
Query: 285 LNYCTHHSPCKNGATC--SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC-KD 341
++ C H PC +G TC + + C C G+ G C C + C +GG C
Sbjct: 1047 IDPC-HSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPS 1105
Query: 342 QEDGY--HCLCPPGYYGLHC--EHSTLSCA-DSPCFNGGSCRERN--QGANYACECPPNF 394
+ G+ C C GY G C + C SPC GSC E G + C CP +
Sbjct: 1106 PKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSS 1165
Query: 395 TGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRC---RPG--FTGTYCELHVSDCARNPC 449
G C+K P A G C R C PG + G C L V D +
Sbjct: 1166 PGPRCQK--------PGAKG--CEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCP 1215
Query: 450 AHG--------GTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPC---FNRATCYTD 498
+H G CH + C F G CE + C F+ C +
Sbjct: 1216 SHSRCWLLFRDGQCHPQCDSEECL----FDGYDCETPPACTPAYDQYCHDHFHNGHC--E 1269
Query: 499 LSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVL 544
+T C G+ G C G P W G LA+L+VL
Sbjct: 1270 KGCNTAEC----GWDGGDCRPEDGDP---EW-----GPSLALLVVL 1303
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 232 bits (591), Expect = 1e-60
Identities = 119/312 (38%), Positives = 158/312 (50%), Gaps = 23/312 (7%)
Query: 222 CLSGCHEQNGYC---SKPAECLCRPGWQG------RLCNECIPHNGCRHGTC-STPWQ-- 269
CLS + N C SK +C C + + C + TC +TP +
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93
Query: 270 --CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
C C G+ G C+ + C +S C++G C C C GY G CE++ E
Sbjct: 94 FLCKCPPGYSGTICETTIGSCGKNS-CQHGGICHQDPIYP-VCICPAGYAGRFCEIDHDE 151
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C S+PC+NG C+D DGY C C PGY G HC+ CA PC N +C N+ Y
Sbjct: 152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCL--NEIGRYT 209
Query: 388 CECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARN 447
C CP N++G NCE ++D C S PC NG C + + C C PGF G +CEL+ +CA
Sbjct: 210 CICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQ 269
Query: 448 PCAHGGTCHDLENGLMCTCP-AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVC 506
PC HGG C D EN C C +GF+G CE T + C S PC N ATC + S D + C
Sbjct: 270 PCLHGGLCVDGENRYSCNCTGSGFTGTHCE--TLMPLCWSKPCHNNATC--EDSVDNYTC 325
Query: 507 NCPYGFVGSRCE 518
+C G+ G++CE
Sbjct: 326 HCWPGYTGAQCE 337
Score = 231 bits (588), Expect = 2e-60
Identities = 131/405 (32%), Positives = 173/405 (42%), Gaps = 88/405 (21%)
Query: 208 CLPGWTGEYCQQPI--CLSGCHEQNGYCSKPA---ECLCRPGWQGRLCNECIPHNGCRHG 262
C PG++G C+ I C + G C + C+C G+ GR C I H+ C
Sbjct: 98 CPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE--IDHDECASS 155
Query: 263 TCSTP---------WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCR 313
C + C C G+ G CD +++ C PCKN ATC N R YTC C
Sbjct: 156 PCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECAS-DPCKNEATCLNEIGR-YTCICP 213
Query: 314 PGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFN 373
Y+GV+CELE+ EC S PC NG +C+D Y C C PG+ G HCE +T CA PC +
Sbjct: 214 HNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLH 273
Query: 374 GGSCRE-------------------------------------RNQGANYACECPPNFTG 396
GG C + + NY C C P +TG
Sbjct: 274 GGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTG 333
Query: 397 SNCEKKVDRCTSNPCANGGQCLNRGPSR--------------------MCRCRPGFTGTY 436
+ CE ++ C SNPC + G+C+ + +C C+PGFTG +
Sbjct: 334 AQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIH 393
Query: 437 CELHVSDCARNPCAHGGTCHDLENGLMCTCPAG------FSGRRCEVRTSIDACASSPCF 490
CE V++C+ NPC +GGTC +L C CP + GR C + C C
Sbjct: 394 CEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCS--DILLGCTHQQCL 451
Query: 491 NRATCYTDLSTDT--FVCNCPYGFVGSRCEFPVGLP---PSFPWV 530
N TC F C CP G+ GS CE L F WV
Sbjct: 452 NNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWV 496
Score = 183 bits (464), Expect = 5e-46
Identities = 115/397 (28%), Positives = 160/397 (40%), Gaps = 88/397 (22%)
Query: 170 SYRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQPDGNLS---CLPGWTGEYCQ--QPI 221
S+ C Y G C C K + G +C D C G+ G +C+
Sbjct: 93 SFLCKCPPGYSGTICETTIGSCGKNSCQHGG-ICHQDPIYPVCICPAGYAGRFCEIDHDE 151
Query: 222 CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCN----ECIPHNGCRHGTCSTP---WQCT 271
C S + C + C C PG+QGR C+ EC TC + C
Sbjct: 152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCI 211
Query: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
C + G+ C+ +++ C PC NGATC ++ +Y C C PG+ G CEL EC S
Sbjct: 212 CPHNYSGVNCELEIDECWSQ-PCLNGATCQDA-LGAYFCDCAPGFLGDHCELNTDECASQ 269
Query: 332 PCRNGG---------------------------------------SCKDQEDGYHCLCPP 352
PC +GG +C+D D Y C C P
Sbjct: 270 PCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWP 329
Query: 353 GYYGLHCEHSTLSCADSPCFNGGSCRE------------------RNQGANYACECPPNF 394
GY G CE C +PC + G C E ++ + Y C C P F
Sbjct: 330 GYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGF 389
Query: 395 TGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRC------RPGFTGTYCELHVSDCARNP 448
TG +CE+ V+ C+SNPC NGG C N + C C R + G C + C
Sbjct: 390 TGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQ 449
Query: 449 CAHGGTC----HDLENGLMCTCPAGFSGRRCEVRTSI 481
C + GTC D ++G C CP+G++G CE+ T++
Sbjct: 450 CLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTL 486
Score = 174 bits (441), Expect = 2e-43
Identities = 84/205 (40%), Positives = 110/205 (53%), Gaps = 12/205 (5%)
Query: 285 LNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED 344
LN C + +PC +G C + SY C+C G++G CEL + EC SNPC +G +C D+
Sbjct: 1140 LNVC-NSNPCLHGGNCEDI-YSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVA 1196
Query: 345 GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV- 403
YHC C PGY G++CE +C C NG +C G Y+C C NFTG C +
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNG--YSCLCFGNFTGKFCRQSRL 1254
Query: 404 ------DRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHD 457
+ T+ C NGG C C CRPGFTG +CE + +CA +PC +GG C D
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQD 1314
Query: 458 LENGLMCTCPAGFSGRRCEVRTSID 482
L N C C F+G RCEV + D
Sbjct: 1315 LLNKFQCLCDVAFAGERCEVDLADD 1339
Score = 171 bits (432), Expect = 3e-42
Identities = 89/243 (36%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 280 FCDQDLNYCTHHSPCKNGATCSN-SGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGS 338
FC+++ C +S C+N +TC + S +C+ DC+ C SNPC+ +
Sbjct: 26 FCNKNNTRCLSNS-CQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 339 CKDQ--EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY-ACECPPNFT 395
C + E + C CPPGY G CE + SC + C +GG C +Q Y C CP +
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGIC---HQDPIYPVCICPAGYA 141
Query: 396 GSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC 455
G CE D C S+PC NG C + C C PG+ G +C+L V +CA +PC + TC
Sbjct: 142 GRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATC 201
Query: 456 HDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGS 515
+ C CP +SG CE+ ID C S PC N ATC L + C+C GF+G
Sbjct: 202 LNEIGRYTCICPHNYSGVNCEL--EIDECWSQPCLNGATCQDALG--AYFCDCAPGFLGD 257
Query: 516 RCE 518
CE
Sbjct: 258 HCE 260
Score = 170 bits (431), Expect = 4e-42
Identities = 98/267 (36%), Positives = 133/267 (49%), Gaps = 26/267 (9%)
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
L+L+ C+SNPC +GG+C+D YHC CP G+ G HCE + C +PC + G+C +R
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDR-- 1194
Query: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYC---EL 439
A Y C C P +TG NCE +D C S+ CANG C++ C C FTG +C L
Sbjct: 1195 VAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRL 1254
Query: 440 HVSDCARN----PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATC 495
+ C C +GG C + + L C C GF+G CE ID CAS PC N C
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCE--KDIDECASDPCVNGGLC 1312
Query: 496 YTDLSTDTFVCNCPYGFVGSRCEFPVG---LPPSFPWVAVSLGVGLAVLLVLLGMVAVAV 552
L + F C C F G RCE + + F + S+ V L ++L+L + +V
Sbjct: 1313 QDLL--NKFQCLCDVAFAGERCEVDLADDLISDIFTTIG-SVTVALLLILLLAIVASVVT 1369
Query: 553 RQLRL--------RRPDDGSREAMNNL 571
R R+ +GSR M NL
Sbjct: 1370 SNKRATQGTYSPSRQEKEGSRVEMWNL 1396
Score = 130 bits (327), Expect = 4e-30
Identities = 59/165 (35%), Positives = 85/165 (51%), Gaps = 6/165 (3%)
Query: 359 CEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418
C + C + C N +C++ ++ + +C N +C+ D C SNPC C+
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 419 NRGPSR--MCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
N R +C+C PG++GT CE + C +N C HGG CH +C CPAG++GR CE
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 477 VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
+ D CASSPC N A C + D + C C G+ G C+ V
Sbjct: 147 I--DHDECASSPCQNGAVCQDGI--DGYSCFCVPGYQGRHCDLEV 187
Score = 122 bits (305), Expect = 1e-27
Identities = 70/198 (35%), Positives = 94/198 (47%), Gaps = 21/198 (10%)
Query: 217 CQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPHNGCRHGTCS---TPWQ 269
C CL G + ++ Y S C C GW G+ C +EC N C HG CS +
Sbjct: 1143 CNSNPCLHGGNCEDIYSSY--HCSCPLGWSGKHCELNIDECFS-NPCIHGNCSDRVAAYH 1199
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDC---ELELS 326
CTC+ G+ G+ C+ D++ C H C NGATC S Y+C C +TG C L +
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQ-CANGATCI-SHTNGYSCLCFGNFTGKFCRQSRLPST 1257
Query: 327 ECDSN----PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
C + C NGG+C + + C+C PG+ G CE CA PC NGG C++
Sbjct: 1258 VCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLN 1317
Query: 383 GANYACECPPNFTGSNCE 400
+ C C F G CE
Sbjct: 1318 --KFQCLCDVAFAGERCE 1333
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/88 (29%), Positives = 40/88 (45%)
Query: 435 TYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRAT 494
++C + + C N C + TC D C+C + + D C S+PC AT
Sbjct: 25 SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 495 CYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
C +F+C CP G+ G+ CE +G
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIG 112
Score = 56.2 bits (134), Expect = 1e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 1/72 (1%)
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCT 465
C SNPC NGG C +R C C +G CE V C +PC HG C + G C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 466 CPAGFSGRRCEV 477
A F+G+ ++
Sbjct: 950 ANAVFNGQSGQI 961
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/73 (36%), Positives = 34/73 (46%), Gaps = 3/73 (4%)
Query: 326 SECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGAN 385
+ C SNPC NGG C + D + C CP G CE C SPC +G C+ QG
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQG-- 945
Query: 386 YACECPPNFTGSN 398
+ C F G +
Sbjct: 946 FECIANAVFNGQS 958
Score = 51.6 bits (122), Expect = 2e-06
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 442 SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLST 501
+ C NPC +GG CH + C+CPA SG+ CE + C SPC + A C L
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE---EVQWCGFSPCPHGAQCQPVLQG 945
Query: 502 DTFVCNCPY 510
+ N +
Sbjct: 946 FECIANAVF 954
Score = 49.7 bits (117), Expect = 9e-06
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 24/140 (17%)
Query: 170 SYRVICSDNYYGDNCS---RLCKKRNDHFGHYVCQPDGNLSCL--PGWTGEYCQQ---PI 221
+Y C Y G NC C+ G SCL +TG++C+Q P
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 222 CLSGCHEQN------GYCSK---PAECLCRPGWQGRLC----NECIPHNGCRHGTCS--- 265
+ G + N G C++ +C+CRPG+ G C +EC G C
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316
Query: 266 TPWQCTCDEGWGGLFCDQDL 285
+QC CD + G C+ DL
Sbjct: 1317 NKFQCLCDVAFAGERCEVDL 1336
Score = 49.3 bits (116), Expect = 1e-05
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 3/53 (5%)
Query: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQC 417
SC +PC NGG C R +++C CP +G CE+ V C +PC +G QC
Sbjct: 890 SCKSNPCHNGGVCHSRWD--DFSCSCPALTSGKACEE-VQWCGFSPCPHGAQC 939
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
+PC NG C +S ++C+C +G CE E+ C +PC +G C+ G+ C+
Sbjct: 894 NPCHNGGVC-HSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECIAN 951
Query: 352 PGYYG 356
+ G
Sbjct: 952 AVFNG 956
Score = 34.3 bits (77), Expect = 0.39
Identities = 15/41 (36%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 397 SNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYC 437
+ C +K D C S PC + G+C+N S C C + G C
Sbjct: 668 AGCVRK-DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 33.1 bits (74), Expect = 0.88
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 482 DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
++C S+PC N C++ D F C+CP G CE
Sbjct: 889 NSCKSNPCHNGGVCHS--RWDDFSCSCPALTSGKACE 923
Score = 30.4 bits (67), Expect = 5.7
Identities = 12/32 (37%), Positives = 17/32 (53%)
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHC 359
C+S PC++ G C + Y C C Y G +C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 224 bits (570), Expect = 3e-58
Identities = 110/292 (37%), Positives = 149/292 (51%), Gaps = 13/292 (4%)
Query: 241 CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC 300
C PG EC C + CTC+E + G FC++ + C PC+N A+C
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDAC-QRKPCQNNASC 364
Query: 301 SNSGQR----SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYG 356
++ ++ ++TC C PGYTG C+ ++ C +PCRNG +C G+ C CP GY+G
Sbjct: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFG 424
Query: 357 LHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQ 416
CE CA SPC N G+C G ++ C C P FTG C + +D C +PCA+G
Sbjct: 425 SACEEKVDPCASSPCQNNGTCYV--DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-T 481
Query: 417 CLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
C + G S C C PG+ G YCE ++C PC + TC DL NG C C A + G CE
Sbjct: 482 CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE 541
Query: 477 VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFP 528
+ D CA+ C N ATC +D T C C GF G C+ + S P
Sbjct: 542 LYK--DPCANVSCLNGATCDSDGLNGT--CICAPGFTGEECDIDINECDSNP 589
Score = 211 bits (538), Expect = 1e-54
Identities = 118/366 (32%), Positives = 171/366 (46%), Gaps = 46/366 (12%)
Query: 143 IAIQGSLAVGQNWLL----DEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHY 198
+ ++ LA+G N + D T ++ LR + V S C H
Sbjct: 268 VLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVST----------CVPGESHANDL 317
Query: 199 VCQPDGNLSCLPG-----------WTGEYCQQ-PICLSGCHEQNGYCSKPAE-------- 238
C G + P + G +C++ C + N C E
Sbjct: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFT 377
Query: 239 CLCRPGWQGRLCNECIPH---NGCRHG-TCSTP---WQCTCDEGWGGLFCDQDLNYCTHH 291
C+C PG+ G LC I + + CR+G TC + + C C EG+ G C++ ++ C
Sbjct: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCAS- 436
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
SPC+N TC G +TC C PG+TG C + C +PC +G +C+ Y CLC
Sbjct: 437 SPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCD 494
Query: 352 PGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411
PGY+GL+CE C +PC N +CR+ G Y C C + G++CE D C + C
Sbjct: 495 PGYHGLYCEEEYNECLSAPCLNAATCRDLVNG--YECVCLAEYKGTHCELYKDPCANVSC 552
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFS 471
NG C + G + C C PGFTG C++ +++C NPC HGG+C D NG C CP G+
Sbjct: 553 LNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612
Query: 472 GRRCEV 477
G CE+
Sbjct: 613 GANCEI 618
Score = 181 bits (459), Expect = 2e-45
Identities = 104/293 (35%), Positives = 138/293 (47%), Gaps = 26/293 (8%)
Query: 170 SYRVICSDNYYG------DNCSRL-CKKRNDHFGHYVCQPDGNLSC--LPGWTGEYCQQP 220
++ C + Y G D C R C+ Q N +C LPG+TGE CQ
Sbjct: 333 TFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
Query: 221 I--CLSGCHEQNGYCSKPAE---CLCRPGWQGRLCNE----CIPHNGCRHGTC---STPW 268
I C+ C C C G+ G C E C +GTC +
Sbjct: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
Query: 269 QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC 328
C C G+ G C Q +++C SPC +G TC + G SY C C PGY G+ CE E +EC
Sbjct: 453 TCNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGT-SYKCLCDPGYHGLYCEEEYNEC 509
Query: 329 DSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYAC 388
S PC N +C+D +GY C+C Y G HCE CA+ C NG +C + G N C
Sbjct: 510 LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD--SDGLNGTC 567
Query: 389 ECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV 441
C P FTG C+ ++ C SNPC +GG CL++ C C G+ G CE+H+
Sbjct: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
Score = 80.1 bits (196), Expect = 6e-15
Identities = 47/140 (33%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 397 SNCEKKVDRCTSNPCANGGQCLNRGPSRM---CRCRPGFTGTYCELHVSDCARNPCAHGG 453
S C C+ G+C + PS C C + GT+CE + + C R PC +
Sbjct: 305 STCVPGESHANDLECSGKGKCTTK-PSEATFSCTCEEQYVGTFCEEYDA-CQRKPCQNNA 362
Query: 454 TCHDLE-----NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNC 508
+C D + C C G++G C+ + ID C PC N ATC + LS F C C
Sbjct: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQ--SKIDYCILDPCRNGATCISSLSG--FTCQC 418
Query: 509 PYGFVGSRCEFPVGLPPSFP 528
P G+ GS CE V S P
Sbjct: 419 PEGYFGSACEEKVDPCASSP 438
Score = 70.1 bits (170), Expect = 6e-12
Identities = 31/84 (36%), Positives = 44/84 (52%), Gaps = 14/84 (16%)
Query: 293 PCKNGATCSN-----------SGQRSYTCTCRPGYTGVDCELELSECDSNPCRNG---GS 338
PC+NG C++ +G+ Y+CTC G +G +C+L C SNPC +G S
Sbjct: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
Query: 339 CKDQEDGYHCLCPPGYYGLHCEHS 362
DGY C+C GY G +CE +
Sbjct: 112 SSSSSDGYLCICNEGYEGPNCEQA 135
Score = 63.5 bits (153), Expect = 6e-10
Identities = 34/99 (34%), Positives = 47/99 (47%), Gaps = 15/99 (15%)
Query: 444 CARNPCAHGGTCHDL------------ENGLMCTCPAGFSGRRCEVRTSIDACASSPCFN 491
CA PC +GG C E G CTCPAG SG C++ D CAS+PC +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL--VADPCASNPCHH 105
Query: 492 -RATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPW 529
+ + S+D ++C C G+ G CE + P+ W
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGW 144
Score = 62.4 bits (150), Expect = 1e-09
Identities = 30/87 (34%), Positives = 39/87 (44%), Gaps = 13/87 (14%)
Query: 328 CDSNPCRNGGSCKDQ------------EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGG 375
C + PCRNGG C + E GY C CP G G +C+ CA +PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 376 -SCRERNQGANYACECPPNFTGSNCEK 401
S + Y C C + G NCE+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/87 (35%), Positives = 40/87 (45%), Gaps = 15/87 (17%)
Query: 366 CADSPCFNGGSCRERNQG----------ANYACECPPNFTGSNCEKKVDRCTSNPCANGG 415
CA PC NGG C R + Y+C CP +G+NC+ D C SNPC + G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
Query: 416 QCLNRGPSR----MCRCRPGFTGTYCE 438
C + S +C C G+ G CE
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 61.6 bits (148), Expect = 2e-09
Identities = 29/86 (33%), Positives = 37/86 (43%), Gaps = 15/86 (17%)
Query: 406 CTSNPCANGGQCLNRG------------PSRMCRCRPGFTGTYCELHVSDCARNPCAHG- 452
C + PC NGG C +R P C C G +G C+L CA NPC HG
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 453 --GTCHDLENGLMCTCPAGFSGRRCE 476
+ +G +C C G+ G CE
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 8/97 (8%)
Query: 234 SKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTP-WQCTCDEGWGGLFCDQDLNYCT--- 289
S P C +P G +C + P + CTC G G C + C
Sbjct: 43 SAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNP 102
Query: 290 -HHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL 325
HH C + ++ S+ G Y C C GY G +CE L
Sbjct: 103 CHHGNCSSSSSSSSDG---YLCICNEGYEGPNCEQAL 136
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/125 (30%), Positives = 49/125 (39%), Gaps = 26/125 (20%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCS 234
C D G C L + + H Y P N+SCL G T + NG
Sbjct: 520 CRDLVNGYECVCLAEYKGTHCELYK-DPCANVSCLNGATCD----------SDGLNG--- 565
Query: 235 KPAECLCRPGWQGRLC----NECIPHNGCRHG-TC---STPWQCTCDEGWGGLFCDQDLN 286
C+C PG+ G C NEC N C HG +C + C C GW G C+ L
Sbjct: 566 ---TCICAPGFTGEECDIDINEC-DSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQ 621
Query: 287 YCTHH 291
+ + H
Sbjct: 622 WKSGH 626
Score = 33.5 bits (75), Expect = 0.67
Identities = 18/65 (27%), Positives = 30/65 (46%), Gaps = 12/65 (18%)
Query: 201 QPDGNLSCLPGWTGEYCQ---QPICLSGCHEQNGYCSKPAE-------CLCRPGWQGRLC 250
+P + +C G +G CQ P + CH +G CS + C+C G++G C
Sbjct: 75 EPGYSCTCPAGISGANCQLVADPCASNPCH--HGNCSSSSSSSSDGYLCICNEGYEGPNC 132
Query: 251 NECIP 255
+ +P
Sbjct: 133 EQALP 137
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 220 bits (561), Expect = 3e-57
Identities = 129/374 (34%), Positives = 165/374 (44%), Gaps = 49/374 (13%)
Query: 186 RLCKKRNDHFGHYVCQPDG------NLSCLPGWTGEYCQQPI--CLSGCHEQNGYCSKPA 237
R C + H G +C P G C+PG+ G C+ I C S C A
Sbjct: 69 RGCATQPCHHGA-LCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLA 127
Query: 238 ---ECLCRPGWQGRLCN---------ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDL 285
EC C G+ G C C+ C G S ++C C G+GG C DL
Sbjct: 128 DRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGS--FRCVCAPGYGGTRCQLDL 185
Query: 286 NYCTHHSPCKNGATCSNSGQRSYTCTCR-PGYTGVDCELELSECDSNPCRNGGSCKDQED 344
+ C PC +G TC + + C C GY G CE E+ EC S PC + SC +
Sbjct: 186 DEC-QSQPCAHGGTCHDL-VNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLG 243
Query: 345 GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA----------------- 387
+ CLC PGY G CE CA SPC +GG C +R+ A Y
Sbjct: 244 SFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAG 303
Query: 388 --CECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA 445
C CPP F G++C +VD C S PC NGG C + C C G+ G CE V +C
Sbjct: 304 FLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECL 363
Query: 446 RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYT--DLSTDT 503
+PC HGGTC D G +C CP + GR C V+ + C C ATC + +
Sbjct: 364 SDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQ--LTGCQGHTCPLAATCIPIFESGVHS 421
Query: 504 FVCNCPYGFVGSRC 517
+VC+CP G G C
Sbjct: 422 YVCHCPPGTHGPFC 435
Score = 217 bits (552), Expect = 3e-56
Identities = 120/331 (36%), Positives = 156/331 (47%), Gaps = 45/331 (13%)
Query: 217 CQQPICLSGCH----EQNGYCSKPAE---CLCRPGWQGRLCNECIPHNGCRHGTCSTPWQ 269
C C G E GY P E C +P G LC +P G T ++
Sbjct: 42 CASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALC---VPQ-----GPDPTGFR 93
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECD 329
C C G+ G C+ D++ C PC +GATC N R Y C C GY GV CE+E+ EC
Sbjct: 94 CYCVPGFQGPRCELDIDECASR-PCHHGATCRNLADR-YECHCPLGYAGVTCEMEVDECA 151
Query: 330 SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACE 389
S PC +GGSC D + C+C PGY G C+ C PC +GG+C + G + C+
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNG--FRCD 209
Query: 390 CP-PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNP 448
C + G++CE++V C S PC + CL S C C PG++G CE+ +CA +P
Sbjct: 210 CAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSP 269
Query: 449 CAHGGTCHDLEN---------------------GLMCTCPAGFSGRRCEVRTSIDACASS 487
C HGG C + G +C CP GF G C V +D CAS
Sbjct: 270 CQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVE--VDECASR 327
Query: 488 PCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
PC N C DL F C+CP G+ G CE
Sbjct: 328 PCLNGGHCQ-DLPNG-FQCHCPDGYAGPTCE 356
Score = 138 bits (348), Expect = 1e-32
Identities = 83/291 (28%), Positives = 122/291 (41%), Gaps = 45/291 (15%)
Query: 170 SYRVICSDNYYGDNC--------SRLCKKR---NDHFGHYVCQPDGNLSCLPGWTGEYCQ 218
S+R +C+ Y G C S+ C +D + C G G+ G +C+
Sbjct: 167 SFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGT-----GYEGTHCE 221
Query: 219 QPI--CLSGCHEQNGYCSK---PAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCD 273
+ + C S E N C + CLC PG+ G LC + + C C +C
Sbjct: 222 REVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCE--VDEDECASSPCQHGGRCLQR 279
Query: 274 EG---WGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS 330
+GG+ + H+ + C C PG+ G DC +E+ EC S
Sbjct: 280 SDPALYGGVQAAFPGAFSFRHA-------------AGFLCHCPPGFEGADCGVEVDECAS 326
Query: 331 NPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACEC 390
PC NGG C+D +G+ C CP GY G CE C PC +GG+C + G Y C C
Sbjct: 327 RPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAG--YICRC 384
Query: 391 PPNFTGSNCEKKVDRCTSNPCANGGQCL----NRGPSRMCRCRPGFTGTYC 437
P + G +C ++ C + C C+ + S +C C PG G +C
Sbjct: 385 PETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 121 bits (304), Expect = 2e-27
Identities = 75/206 (36%), Positives = 101/206 (49%), Gaps = 15/206 (7%)
Query: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM 425
CA SPC + G+CR+ +AC C P + G CE VD C S PCA G +C R
Sbjct: 1060 CAPSPCLHDGACRDLFDA--FACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRF 1116
Query: 426 -CRCRPGFTGTYCELHV--SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI 481
CRC PGF G C L V +C+ N C G C C+C G +G+RC+V T
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTL- 1175
Query: 482 DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLA-- 539
C ++PC N TC +CN F G CE GLP P+ + + V A
Sbjct: 1176 -PCEANPCLNGGTCRAAGGVSECICNA--RFSGQFCEVAKGLPLPLPFPLLEVAVPAACA 1232
Query: 540 -VLLVLLGMVAVAVRQLRLRRPDDGS 564
+LL+LLG+++ + R RR +G+
Sbjct: 1233 CLLLLLLGLLS-GILAARKRRQSEGT 1257
Score = 114 bits (284), Expect = 4e-25
Identities = 56/153 (36%), Positives = 71/153 (46%), Gaps = 5/153 (3%)
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C +PC + G+C+D D + C C PG+ G CE C +PC G C G +
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDG-RFE 1117
Query: 388 CECPPNFTGSNCEKKVD--RCTSN-PCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC 444
C CPP F G C V C+ N C +G C P+ C C G G C++ C
Sbjct: 1118 CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPC 1177
Query: 445 ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV 477
NPC +GGTC C C A FSG+ CEV
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 99.0 bits (245), Expect = 1e-20
Identities = 52/152 (34%), Positives = 69/152 (45%), Gaps = 8/152 (5%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDG-YHCLC 350
SPC + C + ++ C C PG+ G CE + C S PC G C DG + C C
Sbjct: 1063 SPCLHDGACRDLFD-AFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFECRC 1120
Query: 351 PPGYYGLHCEHSTLS--CA-DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT 407
PPG+ G C S C+ + C +G C + AN C C G C+ C
Sbjct: 1121 PPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAAN--CSCLEGLAGQRCQVPTLPCE 1178
Query: 408 SNPCANGGQCLNRGPSRMCRCRPGFTGTYCEL 439
+NPC NGG C G C C F+G +CE+
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 86.7 bits (213), Expect = 7e-17
Identities = 55/193 (28%), Positives = 84/193 (43%), Gaps = 39/193 (20%)
Query: 208 CLPGWTGEYCQ--QPICLSGCHEQNGYCSKPAE------------------------CLC 241
C PG++GE C+ + C S + G C + ++ C C
Sbjct: 249 CWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHC 308
Query: 242 RPGWQGRLC----NECIPHNGCRHGTCS---TPWQCTCDEGWGGLFCDQDLNYCTHHSPC 294
PG++G C +EC G C +QC C +G+ G C++D++ C PC
Sbjct: 309 PPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLS-DPC 367
Query: 295 KNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQ-EDGYH---CLC 350
+G TCS++ Y C C + G DC ++L+ C + C +C E G H C C
Sbjct: 368 LHGGTCSDT-VAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHC 426
Query: 351 PPGYYGLHCEHST 363
PPG +G C +T
Sbjct: 427 PPGTHGPFCGQNT 439
Score = 82.0 bits (201), Expect = 2e-15
Identities = 50/180 (27%), Positives = 76/180 (42%), Gaps = 21/180 (11%)
Query: 193 DHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAE---CLCRPGWQGRL 249
+HF + P L C P+C +G C + C C PGW+G
Sbjct: 1039 EHFASWPGTPAPILGCRGA--------PVCAPSPCLHDGACRDLFDAFACACGPGWEGPR 1090
Query: 250 CNECIP--HNG-CRHGTCST----PWQCTCDEGWGGLFCDQDL--NYCTHHSPCKNGATC 300
C + H+ C G C T ++C C G+GG C + C+ + C +G+ C
Sbjct: 1091 CEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPC 1150
Query: 301 SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE 360
G + C+C G G C++ C++NPC NGG+C+ C+C + G CE
Sbjct: 1151 -EGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 77.4 bits (189), Expect = 4e-14
Identities = 47/126 (37%), Positives = 55/126 (43%), Gaps = 16/126 (12%)
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDL---ENGL 462
C S+PCA G +C S C P + CA PC HG C G
Sbjct: 42 CASDPCAPGTEC-QATESGGYTCGP--------MEPRGCATQPCHHGALCVPQGPDPTGF 92
Query: 463 MCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
C C GF G RCE+ ID CAS PC + ATC D + C+CP G+ G CE V
Sbjct: 93 RCYCVPGFQGPRCEL--DIDECASRPCHHGATCRN--LADRYECHCPLGYAGVTCEMEVD 148
Query: 523 LPPSFP 528
S P
Sbjct: 149 ECASAP 154
Score = 52.4 bits (124), Expect = 1e-06
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 9/77 (11%)
Query: 404 DRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLM 463
D C+ +PC NGG CL C C FTG C + C PC TC ++ +G +
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW-CPGQPCLPPATCEEVPDGFV 867
Query: 464 CTC--------PAGFSG 472
C PA FSG
Sbjct: 868 CVAEATFREGPPAAFSG 884
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/131 (31%), Positives = 49/131 (37%), Gaps = 11/131 (8%)
Query: 276 WGGLF--CDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
WGG F C QDL H P NS Q S + C E C +PC
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFP-LPLDNSSQPSELGGRQSWNLTAGCVSE-DMCSPDPC 816
Query: 334 RNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACEC--- 390
NGG+C + +HC CP + G C L C PC +C E G E
Sbjct: 817 FNGGTCLVTWNDFHCTCPANFTGPTCAQQ-LWCPGQPCLPPATCEEVPDGFVCVAEATFR 875
Query: 391 ---PPNFTGSN 398
P F+G N
Sbjct: 876 EGPPAAFSGHN 886
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/63 (41%), Positives = 32/63 (50%), Gaps = 5/63 (7%)
Query: 444 CARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDT 503
C+ +PC +GGTC N CTCPA F+G C + C PC ATC + D
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL---WCPGQPCLPPATC--EEVPDG 865
Query: 504 FVC 506
FVC
Sbjct: 866 FVC 868
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQC 417
C+ PCFNGG+C ++ C CP NFTG C +++ C PC C
Sbjct: 811 CSPDPCFNGGTCLVTWN--DFHCTCPANFTGPTCAQQL-WCPGQPCLPPATC 859
Score = 37.7 bits (86), Expect = 0.036
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 2/38 (5%)
Query: 480 SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
S D C+ PCFN TC ++ + F C CP F G C
Sbjct: 807 SEDMCSPDPCFNGGTCL--VTWNDFHCTCPANFTGPTC 842
Score = 32.7 bits (73), Expect = 1.1
Identities = 13/32 (40%), Positives = 14/32 (43%)
Query: 444 CARNPCAHGGTCHDLENGLMCTCPAGFSGRRC 475
C PC HGG+C DL C C G C
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 29.6 bits (65), Expect = 9.7
Identities = 15/51 (29%), Positives = 22/51 (43%), Gaps = 3/51 (5%)
Query: 357 LHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT 407
L CE C PC +GGSC + ++ C+C G C ++ T
Sbjct: 601 LGCERRE-QCRPLPCVHGGSCVD--LWTHFRCDCARPHRGPTCADEIPAAT 648
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 217 bits (553), Expect = 3e-56
Identities = 99/227 (43%), Positives = 127/227 (55%), Gaps = 7/227 (3%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
+PC N TC G R Y C C GYTG+ CE ++ EC PC N G CKD + C CP
Sbjct: 1200 NPCHNSGTCQQLG-RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
Query: 352 PGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411
GY G CE + C+ SPC N G C + G Y C C F G +CE +V+ C SNPC
Sbjct: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAG--YRCTCVKGFVGLHCETEVNECQSNPC 1316
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFS 471
N C ++ +C+C PGF GT C +V +C PC +G TC D N C C AGF+
Sbjct: 1317 LNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFT 1376
Query: 472 GRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
G CE+ +I+ C S+PC N+ATC +L +++ C C GF G RCE
Sbjct: 1377 GSHCEL--NINECQSNPCRNQATCVDEL--NSYSCKCQPGFSGKRCE 1419
Score = 206 bits (524), Expect = 6e-53
Identities = 97/234 (41%), Positives = 126/234 (53%), Gaps = 9/234 (3%)
Query: 251 NECIPHNGCRH-GTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQR 306
+EC N C + GTC + C C G+ GL C+ D++ C+ PC N C +
Sbjct: 1195 HECF-FNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP-LPCLNNGVCKDL-VG 1251
Query: 307 SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
+ C C GYTG CE ++EC S+PC N G C D GY C C G+ GLHCE C
Sbjct: 1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMC 426
+PC N C ++ G + C+CPP F G+ C K VD C S PC NG C + S C
Sbjct: 1312 QSNPCLNNAVCEDQVGG--FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
Query: 427 RCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480
C GFTG++CEL++++C NPC + TC D N C C GFSG+RCE S
Sbjct: 1370 LCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
Score = 186 bits (473), Expect = 5e-47
Identities = 84/202 (41%), Positives = 108/202 (53%), Gaps = 6/202 (2%)
Query: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY 386
EC NPC N G+C+ GY CLCP GY GL CE C+ PC N G C++ +
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV--GEF 1253
Query: 387 ACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCAR 446
CECP +TG CE+ ++ C+S+PC N G C++ C C GF G +CE V++C
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
Query: 447 NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVC 506
NPC + C D G +C CP GF G RC ++D C S PC N ATC ++F C
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCG--KNVDECLSQPCKNGATCKD--GANSFRC 1369
Query: 507 NCPYGFVGSRCEFPVGLPPSFP 528
C GF GS CE + S P
Sbjct: 1370 LCAAGFTGSHCELNINECQSNP 1391
Score = 78.2 bits (191), Expect = 2e-14
Identities = 45/106 (42%), Positives = 54/106 (50%), Gaps = 17/106 (16%)
Query: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391
PC+NGG C+ C CP G+ G CE PC NGG C A Y C+CP
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV-----APYQCDCP 3523
Query: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYC 437
P +TGS C V C S PC NGG+C+ P+R C C +TG C
Sbjct: 3524 PGWTGSRCHTAV--CQS-PCLNGGKCVR--PNR-CHCLSSWTGHNC 3563
Score = 76.3 bits (186), Expect = 9e-14
Identities = 48/146 (32%), Positives = 61/146 (41%), Gaps = 20/146 (13%)
Query: 180 YGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCH---EQNGYCSKP 236
YGD + C + Y+ + CL G + PIC + C + G C +P
Sbjct: 3434 YGDMITYSC------YSGYMLEGFLRSVCLEN--GTWTSPPICRAVCRFPCQNGGICQRP 3485
Query: 237 AECLCRPGWQGRLCNECIPHNGCRH-GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCK 295
C C GW GRLC E I C + G C P+QC C GW G C + SPC
Sbjct: 3486 NACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC----HTAVCQSPCL 3541
Query: 296 NGATCSNSGQRSYTCTCRPGYTGVDC 321
NG C R C C +TG +C
Sbjct: 3542 NGGKC----VRPNRCHCLSSWTGHNC 3563
Score = 76.3 bits (186), Expect = 9e-14
Identities = 44/110 (40%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 293 PCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP 352
PC+NG C QR C+C G+ G CE + PC NGG C Y C CPP
Sbjct: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCVAP---YQCDCPP 3524
Query: 353 GYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402
G+ G C T C SPC NGG C N+ C C ++TG NC +K
Sbjct: 3525 GWTGSRCH--TAVC-QSPCLNGGKCVRPNR-----CHCLSSWTGHNCSRK 3566
Score = 71.2 bits (173), Expect = 3e-12
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 4/101 (3%)
Query: 184 CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRP 243
C +C+ + G +CQ SC GW G C++PIC+ C G C P +C C P
Sbjct: 3468 CRAVCRFPCQNGG--ICQRPNACSCPEGWMGRLCEEPICILPCLN-GGRCVAPYQCDCPP 3524
Query: 244 GWQGRLCNECIPHNGCRHG-TCSTPWQCTCDEGWGGLFCDQ 283
GW G C+ + + C +G C P +C C W G C +
Sbjct: 3525 GWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSR 3565
Score = 53.9 bits (128), Expect = 5e-07
Identities = 34/108 (31%), Positives = 41/108 (37%), Gaps = 19/108 (17%)
Query: 410 PCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAG 469
PC NGG C C C G+ G CE + PC +GG C C CP G
Sbjct: 3475 PCQNGGICQR---PNACSCPEGWMGRLCEEPICIL---PCLNGGRC---VAPYQCDCPPG 3525
Query: 470 FSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
++G RC A SPC N C C+C + G C
Sbjct: 3526 WTGSRCHT-----AVCQSPCLNGGKCVRPNR-----CHCLSSWTGHNC 3563
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 13/80 (16%)
Query: 446 RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFV 505
R PC +GG C + C+CP G+ GR CE I PC N C +
Sbjct: 3473 RFPCQNGGIC---QRPNACSCPEGWMGRLCEEPICI-----LPCLNGGRCVAP-----YQ 3519
Query: 506 CNCPYGFVGSRCEFPVGLPP 525
C+CP G+ GSRC V P
Sbjct: 3520 CDCPPGWTGSRCHTAVCQSP 3539
Score = 38.1 bits (87), Expect = 0.027
Identities = 36/152 (23%), Positives = 54/152 (35%), Gaps = 35/152 (23%)
Query: 183 NCSRLCKKRND------------HFGHYVCQPDGNLSCLPGWTGEYCQQPI--CLSGCHE 228
+CS LC + D H GH+ C C G+ G+ Q C SG ++
Sbjct: 276 HCSYLCDEGKDCCDRMGSCKCGTHTGHFEC------ICEKGYYGKGLQYECTACPSGTYK 329
Query: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYC 288
G + C+ C N ++P C C EG+ +L +C
Sbjct: 330 PEGSPGGISSCI-----------PCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378
Query: 289 THHSPCKNG----ATCSNSGQRSYTCTCRPGY 316
P +NG TC+N + C PG+
Sbjct: 379 PALKPPENGYFIQNTCNNHFNAACGVRCHPGF 410
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/161 (24%), Positives = 53/161 (32%), Gaps = 40/161 (24%)
Query: 281 CDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGG--- 337
CD+ + C CK G + + C C GY G + E + C S + G
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGH-----FECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
Query: 338 ---SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACE---CP 391
SC D H PPG S + C CRE + + CE CP
Sbjct: 336 GISSCIPCPDENH-TSPPG-----------STSPEDCV----CREGYRASGQTCELVHCP 379
Query: 392 PNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGF 432
N + C ++ A G RC PGF
Sbjct: 380 ALKPPENGYFIQNTCNNHFNAACG----------VRCHPGF 410
Score = 30.8 bits (68), Expect = 4.3
Identities = 59/254 (23%), Positives = 80/254 (31%), Gaps = 31/254 (12%)
Query: 227 HEQNGYCSKPAECLCRPGWQ-----GRLCNECIPHNG----CRHGTCSTPWQCTCDEGWG 277
H N C PG++ +C E NG C C P T E
Sbjct: 2671 HSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLP---TAPENGF 2727
Query: 278 GLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS-NPCRNG 336
F + + +S CK G + S R C ++G E C NP NG
Sbjct: 2728 LRFTETSMGSAVQYS-CKPGHILAGSDLR--LCLENRKWSGASPRCEAISCKKPNPVMNG 2784
Query: 337 ---GSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPN 393
GS + C PGY E T C D ++ + C PP
Sbjct: 2785 SIKGSNYTYLSTLYYECDPGYVLNGTERRT--CQDDKNWD----EDEPICIPVDCSSPP- 2837
Query: 394 FTGSNCEKKVDRCTSNP----CANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPC 449
+N + + D T N G L SR+C ++G + CA P
Sbjct: 2838 -VSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQ 2896
Query: 450 AHGGTCHDLENGLM 463
G L+ G M
Sbjct: 2897 LANGVTEGLDYGFM 2910
Score = 30.0 bits (66), Expect = 7.4
Identities = 19/63 (30%), Positives = 26/63 (41%), Gaps = 6/63 (9%)
Query: 300 CSNS----GQRSYTCTCRPGYTGVDCE-LELSECD-SNPCRNGGSCKDQEDGYHCLCPPG 353
C+N G CT + GV L++ EC + C SC + + Y C C P
Sbjct: 1716 CNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPP 1775
Query: 354 YYG 356
Y G
Sbjct: 1776 YTG 1778
Score = 30.0 bits (66), Expect = 7.4
Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 24/86 (27%)
Query: 350 CPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT-S 408
C GYY L S + C D+ +NG S +C VD C
Sbjct: 1716 CNNGYYLLG--DSRMFCTDNGSWNGVS--------------------PSC-LDVDECAVG 1752
Query: 409 NPCANGGQCLNRGPSRMCRCRPGFTG 434
+ C+ CLN S +C C P +TG
Sbjct: 1753 SDCSEHASCLNVDGSYICSCVPPYTG 1778
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 217 bits (552), Expect = 3e-56
Identities = 100/249 (40%), Positives = 128/249 (51%), Gaps = 14/249 (5%)
Query: 197 HYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH 256
H VC L C+ G G+ + C S C +G C+ C C PGW+G C C+
Sbjct: 9 HLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
Query: 257 NGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGY 316
GC+HGTC PWQC C GW G FCD+D + CT SPC+NG C G Y C C PG+
Sbjct: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
Query: 317 TGVDCELELSECD--SNPCRNGGSCKDQED---GYHCLCPPGYYGLHCEHSTLSCADSPC 371
G DCE + C+ +PCRNGG C+D + + C C G+ G CE + C PC
Sbjct: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC 183
Query: 372 FNGGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRP 430
NG +C + G N ++C CP F G C +D C S PC G +C +R C C
Sbjct: 184 ANGATCLD---GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
Query: 431 GFTGTYCEL 439
G+ G CEL
Sbjct: 241 GYGGKTCEL 249
Score = 187 bits (476), Expect = 2e-47
Identities = 98/262 (37%), Positives = 131/262 (50%), Gaps = 23/262 (8%)
Query: 224 SGCHEQNGYCSKPAECLCRPGWQGR--LCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFC 281
SGC + C LC G G+ ++C H HG C+ C CD GW GL C
Sbjct: 3 SGCRCLHLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
Query: 282 DQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS-NPCRNGGSCK 340
++ C C++G TC Q C C G+ G C+ + C + +PC+NGG C
Sbjct: 58 ER----CVRMPGCQHG-TCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCM 108
Query: 341 DQEDG-YHCLCPPGYYGLHCEHSTLSC--ADSPCFNGGSCRERNQG--ANYACECPPNFT 395
G YHC+C PG++G CE C A SPC NGG C++ +QG N+ C C F
Sbjct: 109 YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFV 167
Query: 396 GSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC 455
G+ CE VD C PCANG CL+ C C GF G +C +++ DCA PC G C
Sbjct: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
Query: 456 HDLENGLMCTCPAGFSGRRCEV 477
D + C CP+G+ G+ CE+
Sbjct: 228 RDRVHDFDCLCPSGYGGKTCEL 249
Score = 166 bits (420), Expect = 7e-41
Identities = 97/265 (36%), Positives = 126/265 (47%), Gaps = 23/265 (8%)
Query: 288 CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYH 347
C+ H +G C+ G +C C PG+ G+ CE C P G+C +
Sbjct: 29 CSSHCDLAHGC-CAPDG----SCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQ 76
Query: 348 CLCPPGYYGLHCEHSTLSCA-DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC 406
C+C G+ G C+ C SPC NGG C + G Y C C P F G +CE+K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMY-DGGGEYHCVCLPGFHGRDCERKAGPC 135
Query: 407 --TSNPCANGGQCLNRGPSRM---CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENG 461
+PC NGGQC + + CRC GF G CE++V DC PCA+G TC D N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 462 LMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
C CP GF+GR C + ++D CAS PC A C F C CP G+ G CE +
Sbjct: 196 FSCLCPEGFAGRFCTI--NLDDCASRPCQRGARCRD--RVHDFDCLCPSGYGGKTCELVL 251
Query: 522 GLPPSFPWVAVSLGVGLAVLLVLLG 546
+P V LG AV++ G
Sbjct: 252 PVPDPPTTVDTPLGPTSAVVVPATG 276
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 217 bits (552), Expect = 3e-56
Identities = 100/249 (40%), Positives = 128/249 (51%), Gaps = 14/249 (5%)
Query: 197 HYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH 256
H VC L C+ G G+ + C S C +G C+ C C PGW+G C C+
Sbjct: 9 HLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
Query: 257 NGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGY 316
GC+HGTC PWQC C GW G FCD+D + CT SPC+NG C G Y C C PG+
Sbjct: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
Query: 317 TGVDCELELSECD--SNPCRNGGSCKDQED---GYHCLCPPGYYGLHCEHSTLSCADSPC 371
G DCE + C+ +PCRNGG C+D + + C C G+ G CE + C PC
Sbjct: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC 183
Query: 372 FNGGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRP 430
NG +C + G N ++C CP F G C +D C S PC G +C +R C C
Sbjct: 184 ANGATCLD---GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
Query: 431 GFTGTYCEL 439
G+ G CEL
Sbjct: 241 GYGGKTCEL 249
Score = 187 bits (476), Expect = 2e-47
Identities = 98/262 (37%), Positives = 131/262 (50%), Gaps = 23/262 (8%)
Query: 224 SGCHEQNGYCSKPAECLCRPGWQGR--LCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFC 281
SGC + C LC G G+ ++C H HG C+ C CD GW GL C
Sbjct: 3 SGCRCLHLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
Query: 282 DQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS-NPCRNGGSCK 340
++ C C++G TC Q C C G+ G C+ + C + +PC+NGG C
Sbjct: 58 ER----CVRMPGCQHG-TCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCM 108
Query: 341 DQEDG-YHCLCPPGYYGLHCEHSTLSC--ADSPCFNGGSCRERNQG--ANYACECPPNFT 395
G YHC+C PG++G CE C A SPC NGG C++ +QG N+ C C F
Sbjct: 109 YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFV 167
Query: 396 GSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTC 455
G+ CE VD C PCANG CL+ C C GF G +C +++ DCA PC G C
Sbjct: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
Query: 456 HDLENGLMCTCPAGFSGRRCEV 477
D + C CP+G+ G+ CE+
Sbjct: 228 RDRVHDFDCLCPSGYGGKTCEL 249
Score = 166 bits (420), Expect = 7e-41
Identities = 97/265 (36%), Positives = 126/265 (47%), Gaps = 23/265 (8%)
Query: 288 CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYH 347
C+ H +G C+ G +C C PG+ G+ CE C P G+C +
Sbjct: 29 CSSHCDLAHGC-CAPDG----SCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQ 76
Query: 348 CLCPPGYYGLHCEHSTLSCA-DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC 406
C+C G+ G C+ C SPC NGG C + G Y C C P F G +CE+K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMY-DGGGEYHCVCLPGFHGRDCERKAGPC 135
Query: 407 --TSNPCANGGQCLNRGPSRM---CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENG 461
+PC NGGQC + + CRC GF G CE++V DC PCA+G TC D N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 462 LMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
C CP GF+GR C + ++D CAS PC A C F C CP G+ G CE +
Sbjct: 196 FSCLCPEGFAGRFCTI--NLDDCASRPCQRGARCRD--RVHDFDCLCPSGYGGKTCELVL 251
Query: 522 GLPPSFPWVAVSLGVGLAVLLVLLG 546
+P V LG AV++ G
Sbjct: 252 PVPDPPTTVDTPLGPTSAVVVPATG 276
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 216 bits (549), Expect = 7e-56
Identities = 94/222 (42%), Positives = 123/222 (55%), Gaps = 9/222 (4%)
Query: 222 CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFC 281
C C+ QNG+C C C+PGWQG LC++C+ GC HG C P QC C +GW G C
Sbjct: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELC 85
Query: 282 DQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC--DSNPCRNGGSC 339
D+D+ C+ +PC N TC + Y C+C PGY+G DC+ + C + +PC++GG+C
Sbjct: 86 DRDVRACS-SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
Query: 340 KDQE---DGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTG 396
D E CLCPPG+ G CE SC +PC N G C + G ++ C CP F
Sbjct: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD--IGGDFRCRCPAGFID 202
Query: 397 SNCEKKVDRCTSNPCANGGQCLNRGP-SRMCRCRPGFTGTYC 437
C + V C S+PC NGG CL S C C+P FTG C
Sbjct: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 170 bits (430), Expect = 5e-42
Identities = 84/234 (35%), Positives = 116/234 (49%), Gaps = 19/234 (8%)
Query: 180 YGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAEC 239
YG C C +N C+ D C PGW G C Q + GC +G C +P +C
Sbjct: 22 YGAECFPACNPQNGF-----CEDDNVCRCQPGWQGPLCDQCVTSPGC--LHGLCGEPGQC 74
Query: 240 LCRPGWQGRLCNE----CIPHNGCRHGTCST----PWQCTCDEGWGGLFCDQDLNYCT-H 290
+C GW G LC+ C +GTC + ++C+C G+ G C + C +
Sbjct: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
Query: 291 HSPCKNGATC-SNSGQRSY-TCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC 348
SPC++G TC + G+ S+ +C C PG++G CE+ + C NPC N G C D + C
Sbjct: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
Query: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402
CP G+ C +CA SPC NGG+C + Q +Y C C P FTG C KK
Sbjct: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ-VSYECLCKPEFTGLTCVKK 247
Score = 167 bits (424), Expect = 2e-41
Identities = 87/229 (37%), Positives = 112/229 (48%), Gaps = 14/229 (6%)
Query: 252 ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 311
EC P ++G C C C GW G CDQ C C +G C GQ C
Sbjct: 25 ECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGL-CGEPGQ----CI 75
Query: 312 CRPGYTGVDCELELSECDSNPCRNGGSCKDQEDG-YHCLCPPGYYGLHCEHSTLSCA--D 368
C G+ G C+ ++ C S PC N G+C +DG Y C C PGY G C+ C
Sbjct: 76 CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
Query: 369 SPCFNGGSCRERNQGANYA-CECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCR 427
SPC +GG+C + A++A C CPP F+G+ CE + CT NPC N G C + G CR
Sbjct: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCR 195
Query: 428 CRPGFTGTYCELHVSDCARNPCAHGGTC-HDLENGLMCTCPAGFSGRRC 475
C GF C V++CA +PC +GGTC + C C F+G C
Sbjct: 196 CPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 151 bits (382), Expect = 2e-36
Identities = 84/257 (32%), Positives = 122/257 (47%), Gaps = 23/257 (8%)
Query: 310 CTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADS 369
C C+PG+ G C+ +C ++P G C + C+C G+ G C+ +C+ +
Sbjct: 43 CRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ---CICTDGWDGELCDRDVRACSSA 95
Query: 370 PCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSN--PCANGGQCLN---RGPSR 424
PC N G+C + G Y C C P ++G +C+KK C N PC +GG C++ R
Sbjct: 96 PCANNGTCVSLDDGL-YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
Query: 425 MCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
C C PGF+G +CE+ + C NPC + G C D+ C CPAGF + C + C
Sbjct: 155 SCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCS--RPVTNC 212
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVL 544
ASSPC N TC ++ C C F G C L P + G GLA L
Sbjct: 213 ASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTCVKKRALSPQ-QVTRLPSGYGLAYRL-- 268
Query: 545 LGMVAVAVRQLRLRRPD 561
V +L +++P+
Sbjct: 269 ----TPGVHELPVQQPE 281
Score = 123 bits (309), Expect = 5e-28
Identities = 71/185 (38%), Positives = 89/185 (48%), Gaps = 19/185 (10%)
Query: 343 EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402
ED C C PG+ G C+ C SP G C E Q C C + G C++
Sbjct: 38 EDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQ-----CICTDGWDGELCDRD 88
Query: 403 VDRCTSNPCANGGQCLNRGPSRM-CRCRPGFTGTYCELHVSDCARN--PCAHGGTCHDLE 459
V C+S PCAN G C++ C C PG++G C+ C N PC HGGTC D E
Sbjct: 89 VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
Query: 460 ---NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSR 516
+ C CP GFSG CE+ ++C +PC N C TD+ D F C CP GF+
Sbjct: 149 GRASHASCLCPPGFSGNFCEI--VANSCTPNPCENDGVC-TDIGGD-FRCRCPAGFIDKT 204
Query: 517 CEFPV 521
C PV
Sbjct: 205 CSRPV 209
Score = 93.2 bits (230), Expect = 7e-19
Identities = 55/162 (33%), Positives = 74/162 (45%), Gaps = 16/162 (9%)
Query: 361 HSTLSCADSPCFN--GGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418
HST P N G C + N C C P + G C D+C ++P G C
Sbjct: 19 HSTYGAECFPACNPQNGFCEDDN-----VCRCQPGWQGPLC----DQCVTSPGCLHGLC- 68
Query: 419 NRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLM-CTCPAGFSGRRCEV 477
G C C G+ G C+ V C+ PCA+ GTC L++GL C+C G+SG+ C+
Sbjct: 69 --GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK 126
Query: 478 RTSIDACASSPCFNRATCYTDLSTDTFV-CNCPYGFVGSRCE 518
+ SPC + TC D + C CP GF G+ CE
Sbjct: 127 KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCE 168
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 209 bits (533), Expect = 5e-54
Identities = 117/299 (39%), Positives = 154/299 (51%), Gaps = 24/299 (8%)
Query: 193 DHFGHYVC---QPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAE---CLCRPGWQ 246
D G+Y C +P L C TG++ CLS G C + C C G+
Sbjct: 404 DLVGNYTCLCAEPFKGLRCE---TGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFM 460
Query: 247 GRLCNECIPHN-GCRHG-TC--STPWQCTCDEGWGGLFCDQDLNY--CTHHSPCKNGATC 300
G C E +P + CR+G C + C C G+ GL C+ ++ C ++ C +G C
Sbjct: 461 GLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYC 520
Query: 301 SNSGQRSYTCTCRPGYTGVDCELEL-SECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHC 359
G SY C C +T + L S CDS+PC NGGSC +D Y C CP G++G HC
Sbjct: 521 MEHGG-SYLCVC---HTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHC 576
Query: 360 EHSTLS-CADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQC 417
E + C+ PC NGG+C+E G Y C CP FTG +CE K D C S PC NGG C
Sbjct: 577 EKARPHLCSSGPCRNGGTCKE--AGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTC 634
Query: 418 LNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
+ C C PGF+G +CE+ S C R+PC +GGTC D + C C AG+ GRRC+
Sbjct: 635 FHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQ 693
Score = 204 bits (518), Expect = 3e-52
Identities = 125/397 (31%), Positives = 165/397 (41%), Gaps = 88/397 (22%)
Query: 193 DHFGHY--VCQPDGNLS-CLPGWTGEYCQQPICLSGCHEQNGYCSKPAE---CLCRPGWQ 246
+H G Y VC D N S LP C C +G G C + C C G+
Sbjct: 522 EHGGSYLCVCHTDHNASHSLPS----PCDSDPCFNG-----GSCDAHDDSYTCECPRGFH 572
Query: 247 GRLCNECIPH----NGCRHG-TCSTP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGA 298
G+ C + PH CR+G TC + C+C + G C+ PC NG
Sbjct: 573 GKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGG 632
Query: 299 TCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLH 358
TC + + Y C C PG++G CE+ S C +PC NGG+C+D++ + C C GY G
Sbjct: 633 TCFHYIGK-YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRR 691
Query: 359 CE------------HSTL------------------------------------------ 364
C+ H+TL
Sbjct: 692 CQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQC 751
Query: 365 ----SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR 420
C PC +GGSC++R G Y C C + G++CE + D C ++PC NGG C N
Sbjct: 752 LEIDECRSQPCLHGGSCQDRVAG--YLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNL 809
Query: 421 GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480
+ +CRC GF G +CE V C +PC HGG C +C CP F G CE T
Sbjct: 810 PGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCE--TV 867
Query: 481 IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
D C SSPC R C S + C C G+ G C
Sbjct: 868 SDPCFSSPCGGRGYCLA--SNGSHSCTCKVGYTGEDC 902
Score = 197 bits (500), Expect = 4e-50
Identities = 116/369 (31%), Positives = 162/369 (43%), Gaps = 84/369 (22%)
Query: 214 GEYCQQP----ICLSGCH-EQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPW 268
G YC + +C+ CH + N S P+ C P + G C+ H T
Sbjct: 517 GGYCMEHGGSYLCV--CHTDHNASHSLPSPCDSDPCFNGGSCDA--------HDDSYT-- 564
Query: 269 QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL-ELSE 327
C C G+ G C++ + PC+NG TC +G Y C+C +TG CE+ +
Sbjct: 565 -CECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE-YHCSCPYRFTGRHCEIGKPDS 622
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
C S PC NGG+C Y C CPPG+ G HCE + C SPC NGG+C +R+ ++
Sbjct: 623 CASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRD--TDFF 680
Query: 388 CEC----------------PPN--------FTGSN--------CEK-------------- 401
C C PP F G+ C++
Sbjct: 681 CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQ 740
Query: 402 ------------KVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPC 449
++D C S PC +GG C +R +C C G+ G +CEL +C +PC
Sbjct: 741 PHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPC 800
Query: 450 AHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCP 509
+GG+C +L +C CPAGF G CE T +DAC SSPC + C + ++C CP
Sbjct: 801 RNGGSCRNLPGAYVCRCPAGFVGVHCE--TEVDACDSSPCQHGGRC--ESGGGAYLCVCP 856
Query: 510 YGFVGSRCE 518
F G CE
Sbjct: 857 ESFFGYHCE 865
Score = 194 bits (494), Expect = 2e-49
Identities = 118/369 (31%), Positives = 160/369 (43%), Gaps = 83/369 (22%)
Query: 202 PDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRH 261
P SCL G+TG C + EC +P C C H
Sbjct: 293 PSYTCSCLSGFTGRRCHLDV---------------NECASQP---------CQNGGTCTH 328
Query: 262 GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDC 321
G S ++C C G+GG C+ + C C++G C S C C+ GYTG C
Sbjct: 329 GINS--FRCQCPAGFGGPTCETAQSPC-DTKECQHGGQCQVE-NGSAVCVCQAGYTGAAC 384
Query: 322 ELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL----SCADSPCFNGGSC 377
E+++ +C +PC NGGSC D Y CLC + GL CE +C +PC NGG+C
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444
Query: 378 RERNQGANYACECPPNFTGSNCEKKV-DRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTY 436
+ +QG Y CECP F G +C ++V D C C NGG+CL + +C+C GF G
Sbjct: 445 VDADQG--YVCECPEGFMGLDCRERVPDDC---ECRNGGRCLGAN-TTLCQCPLGFFGLL 498
Query: 437 CELHV---------------------------------------SDCARNPCAHGGTCHD 457
CE + S C +PC +GG+C
Sbjct: 499 CEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDA 558
Query: 458 LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
++ C CP GF G+ CE + C+S PC N TC + + C+CPY F G C
Sbjct: 559 HDDSYTCECPRGFHGKHCE-KARPHLCSSGPCRNGGTCKE--AGGEYHCSCPYRFTGRHC 615
Query: 518 EFPVGLPPS 526
E +G P S
Sbjct: 616 E--IGKPDS 622
Score = 192 bits (489), Expect = 7e-49
Identities = 97/252 (38%), Positives = 126/252 (50%), Gaps = 16/252 (6%)
Query: 281 CDQDLNYCTHHSPCKNGATCSN---SGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGG 337
C + C PC NG C + +G SYTC+C G+TG C L+++EC S PC+NGG
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 338 SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGS 397
+C + + C CP G+ G CE + C C +GG C+ N A C C +TG+
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSA--VCVCQAGYTGA 382
Query: 398 NCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCEL---HVSD-CARNPCAHGG 453
CE VD C+ +PC NGG C++ + C C F G CE V D C PC +GG
Sbjct: 383 ACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGG 442
Query: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
TC D + G +C CP GF G C R D C N C L +T +C CP GF
Sbjct: 443 TCVDADQGYVCECPEGFMGLDCRERVPDDC----ECRNGGRC---LGANTTLCQCPLGFF 495
Query: 514 GSRCEFPVGLPP 525
G CEF + P
Sbjct: 496 GLLCEFEITAMP 507
Score = 183 bits (465), Expect = 4e-46
Identities = 110/352 (31%), Positives = 143/352 (40%), Gaps = 63/352 (17%)
Query: 209 LPG-WTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTP 267
+PG W + + GC C CL G+ ++C+ N
Sbjct: 247 VPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNG----GKCIDDCVTGN--------PS 294
Query: 268 WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE 327
+ C+C G+ G C D+N C PC+NG TC++ G S+ C C G+ G CE S
Sbjct: 295 YTCSCLSGFTGRRCHLDVNECASQ-PCQNGGTCTH-GINSFRCQCPAGFGGPTCETAQSP 352
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYA 387
CD+ C++GG C+ + C+C GY G CE C+ PC NGGSC + NY
Sbjct: 353 CDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLV--GNYT 410
Query: 388 CECPPNFTGSNCEKK----VDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD 443
C C F G CE D C S PC NGG C++ +C C GF G C V D
Sbjct: 411 CLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPD 470
Query: 444 CARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI---------------------- 481
C +GG C N +C CP GF G CE +
Sbjct: 471 DCE--CRNGGRCLGA-NTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSY 527
Query: 482 ---------------DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C S PCFN +C D D++ C CP GF G CE
Sbjct: 528 LCVCHTDHNASHSLPSPCDSDPCFNGGSC--DAHDDSYTCECPRGFHGKHCE 577
Score = 125 bits (313), Expect = 2e-28
Identities = 60/179 (33%), Positives = 91/179 (50%), Gaps = 15/179 (8%)
Query: 228 EQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCS---TPWQCTCDEGWGGLFCDQD 284
+ +G S+P +CL +EC G+C + C C G+ G C+ +
Sbjct: 740 QPHGVWSEPPQCL--------EIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELE 791
Query: 285 LNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED 344
+ C H PC+NG +C N +Y C C G+ GV CE E+ CDS+PC++GG C+
Sbjct: 792 RDECRAH-PCRNGGSCRNL-PGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGG 849
Query: 345 GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV 403
Y C+CP ++G HCE + C SPC G C N +++C C +TG +C K++
Sbjct: 850 AYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASN--GSHSCTCKVGYTGEDCAKEL 906
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 54/175 (30%)
Query: 199 VCQPDGNLSCLPGWTG-EYCQQPICLSG--CHEQ-NGYCSKPAECLCRPGWQGRLC---- 250
VCQP G S P + C+ CL G C ++ GY CLC G++G C
Sbjct: 738 VCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYL-----CLCSTGYEGAHCELER 792
Query: 251 NECIPHNGCRHGTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG--- 304
+EC H G+C + C C G+ G+ C+ +++ C SPC++G C + G
Sbjct: 793 DECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDS-SPCQHGGRCESGGGAY 851
Query: 305 ----------------------------------QRSYTCTCRPGYTGVDCELEL 325
S++CTC+ GYTG DC EL
Sbjct: 852 LCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 13/63 (20%)
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCA------------HGG 453
C+ NPC NGG C+ + C C PGF G CEL +R PC GG
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSR-PCTRLFSETKAFPVWEGG 1369
Query: 454 TCH 456
CH
Sbjct: 1370 VCH 1372
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/49 (44%), Positives = 27/49 (55%), Gaps = 7/49 (14%)
Query: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC--ASSPC 489
+C+ NPC +GGTC + C C GF GRRCE+ AC S PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL-----ACIKVSRPC 1353
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 1/44 (2%)
Query: 328 CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPC 371
C NPC+NGG+C D + C C PG+ G CE + + PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353
Score = 39.7 bits (91), Expect = 0.009
Identities = 19/48 (39%), Positives = 29/48 (60%), Gaps = 5/48 (10%)
Query: 365 SCADSPCFNGGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNPC 411
+C+++PC NGG+C GA+ ++C+C P F G CE + S PC
Sbjct: 1310 NCSENPCQNGGTC---VPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353
Score = 38.9 bits (89), Expect = 0.016
Identities = 18/42 (42%), Positives = 25/42 (59%), Gaps = 2/42 (4%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
+PC+NG TC G +++C C PG+ G CEL + S PC
Sbjct: 1314 NPCQNGGTCV-PGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 34.7 bits (78), Expect = 0.30
Identities = 15/35 (42%), Positives = 18/35 (51%), Gaps = 2/35 (5%)
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C+ +PC N TC D C+C GF G RCE
Sbjct: 1311 CSENPCQNGGTCVP--GADAHSCDCGPGFKGRRCE 1343
Score = 33.9 bits (76), Expect = 0.51
Identities = 20/56 (35%), Positives = 24/56 (42%), Gaps = 3/56 (5%)
Query: 475 CEVRTSIDACASSPCFNRATCYTDLSTD--TFVCNCPYGFVGSRCEFPVGLPPSFP 528
C TS+ A PC N C D T ++ C+C GF G RC V S P
Sbjct: 265 CGHTTSV-CLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQP 319
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 196 bits (498), Expect = 6e-50
Identities = 121/370 (32%), Positives = 177/370 (47%), Gaps = 38/370 (10%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC---KDQEDGYHC 348
+PCKN TC++ Y CTC G+ G DC++ + C SNPC++GG+C + +EDG+ C
Sbjct: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWC 984
Query: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
+C G+ G +CE + C D+ C N +C + NY C CPP +TG CE+K+D C
Sbjct: 985 ICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN--NYTCLCPPEYTGELCEEKLDFCAQ 1042
Query: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
NPC + +C+ C C PG+ G +C++ DC N C +G C D NG C C
Sbjct: 1043 DLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCIC 1102
Query: 467 PAGFSGRRCE-----VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
P G+SG CE V C + C N A C ++ +C C G+ G +CE V
Sbjct: 1103 PEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP--ICQCLPGYQGEKCEKLV 1160
Query: 522 GLP----------PSF---PWVAVSLGVGL---AVLLVLLG---MVAVAVRQLRLRRP-D 561
+ PS P ++L + + +L+ G +AV + + R+R D
Sbjct: 1161 SVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYD 1220
Query: 562 DGSREAMNNLS-DFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPG 620
GS A S + D +L +Q L VD G K + TL+++
Sbjct: 1221 TGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFD---S 1277
Query: 621 PLGRGTMPGK 630
PL G MPGK
Sbjct: 1278 PLYVGGMPGK 1287
Score = 152 bits (384), Expect = 1e-36
Identities = 81/229 (35%), Positives = 113/229 (49%), Gaps = 13/229 (5%)
Query: 306 RSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCK-DQEDGYHCLCPPGYYGLHCEHSTL 364
+ +TC G V+ + + C SNPC+N G+C D D Y C CP G+ G C+
Sbjct: 903 KKFTCQ---GPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIH 959
Query: 365 SCADSPCFNGGSCR-ERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPS 423
+C +PC +GG+C + + + C C F G NCE VD C N C N C++ +
Sbjct: 960 ACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN 1019
Query: 424 RMCRCRPGFTGTYCELHVSDCAR--NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI 481
C C P +TG CE + CA+ NPC H C G C C G+ G C++
Sbjct: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDI--DF 1077
Query: 482 DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF--PVGLPPSFP 528
D C + C N A C TD + + + C CP G+ G CEF P+ LP + P
Sbjct: 1078 DDCQDNKCKNGAHC-TD-AVNGYTCICPEGYSGLFCEFSPPMVLPRTSP 1124
Score = 145 bits (367), Expect = 9e-35
Identities = 90/260 (34%), Positives = 126/260 (48%), Gaps = 39/260 (15%)
Query: 217 CQQPI----------CLSGCHEQNGYC-SKPAE---CLCRPGWQGRLCN----ECIPHNG 258
CQ P+ CLS + +G C S P + C C G++G+ C+ CI N
Sbjct: 907 CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACIS-NP 965
Query: 259 CRHG-TCSTP------WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 311
C+HG TC + C C +G+ G C+ +++ C + C+N +TC + G +YTC
Sbjct: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDND-CENNSTCVD-GINNYTCL 1023
Query: 312 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADS 369
C P YTG CE +L C D NPC++ C G+ C C PGY G HC+ C D+
Sbjct: 1024 CPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDN 1083
Query: 370 PCFNGGSCRERNQGANYACECPPNFTGSNCE-------KKVDRCTSNPCANGGQCLNRGP 422
C NG C + G Y C CP ++G CE + C + C NG QC+ R
Sbjct: 1084 KCKNGAHCTDAVNG--YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRIN 1141
Query: 423 SRMCRCRPGFTGTYCELHVS 442
+C+C PG+ G CE VS
Sbjct: 1142 EPICQCLPGYQGEKCEKLVS 1161
Score = 90.1 bits (222), Expect = 6e-18
Identities = 63/203 (31%), Positives = 88/203 (43%), Gaps = 46/203 (22%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
IC+D + G+NC D+ + N +C+ G N Y
Sbjct: 985 ICADGFEGENCEVNVDDCEDN------DCENNSTCVDG-----------------INNY- 1020
Query: 234 SKPAECLCRPGWQGRLCNECIPH-----NGCRHGT--CSTP--WQCTCDEGWGGLFCDQD 284
CLC P + G LC E + N C+H + TP ++C C G+ G CD D
Sbjct: 1021 ----TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID 1076
Query: 285 LNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL-------ELSECDSNPCRNGG 337
+ C + CKNGA C+++ YTC C GY+G+ CE S CD+ C+NG
Sbjct: 1077 FDDC-QDNKCKNGAHCTDA-VNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGA 1134
Query: 338 SCKDQEDGYHCLCPPGYYGLHCE 360
C + + C C PGY G CE
Sbjct: 1135 QCIVRINEPICQCLPGYQGEKCE 1157
Score = 74.7 bits (182), Expect = 3e-13
Identities = 67/219 (30%), Positives = 91/219 (41%), Gaps = 33/219 (15%)
Query: 209 LPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPHNGCRHGTC 264
LPG E C + +C G + + C C+ GW G LC N+ N C HGTC
Sbjct: 1330 LPGC--EPCHKKVCAHGTCQPSSQAG--FTCECQEGWMGPLCDQRTNDPCLGNKCVHGTC 1385
Query: 265 ----STPWQCTCDEGWGGLFCD--QDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTG 318
+ + C C EG GG+ CD +DL CK+G C SG C C GYTG
Sbjct: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTG 1444
Query: 319 VDCELELSECDSNPCRNGGSCKD---QEDGY-HCLCPPGYYGLHCEHSTLSCADSPCFNG 374
C+ E+S CR G +D ++ GY C L C CA C
Sbjct: 1445 DSCDREIS------CR-GERIRDYYQKQQGYAACQTTKKVSRLECRG---GCAGGQCC-- 1492
Query: 375 GSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCAN 413
G R + + Y+ EC + + +KV +C C +
Sbjct: 1493 GPLRSKRR--KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1529
Score = 72.0 bits (175), Expect = 2e-12
Identities = 60/185 (32%), Positives = 75/185 (40%), Gaps = 26/185 (14%)
Query: 259 CRHGTCSTPWQ----CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRP 314
C HGTC Q C C EGW G CDQ N + C +G TC SY+C C
Sbjct: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLE 1399
Query: 315 GYTGVDCELE---LSECDSNPCRNGGSCKDQEDGY-HCLCPPGYYGLHCEHSTLSCADSP 370
G+ GV C+ E + C + C++ G C+ G +C C GY G C+ +SC
Sbjct: 1400 GHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCDRE-ISC---- 1453
Query: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRP 430
G R+ Q C KKV R GGQC GP R R +
Sbjct: 1454 --RGERIRDYYQKQQGYAAC-------QTTKKVSRLECRGGCAGGQCC--GPLRSKRRKY 1502
Query: 431 GFTGT 435
F T
Sbjct: 1503 SFECT 1507
Score = 53.1 bits (126), Expect = 8e-07
Identities = 37/135 (27%), Positives = 58/135 (42%), Gaps = 12/135 (8%)
Query: 314 PGYTGV--DCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLS-CADSP 370
P TG+ CE C C +G + G+ C C G+ G C+ T C +
Sbjct: 1324 PMQTGILPGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNK 1379
Query: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVD---RCTSNPCANGGQCLNRGPSRMCR 427
C + G+C N +Y+C+C G C+++ D C + C +G L+ C
Sbjct: 1380 CVH-GTCLPIN-AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCE 1437
Query: 428 CRPGFTGTYCELHVS 442
C G+TG C+ +S
Sbjct: 1438 CSSGYTGDSCDREIS 1452
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/123 (26%), Positives = 46/123 (37%), Gaps = 13/123 (10%)
Query: 399 CEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD-CARNPCAHGGTCHD 457
C KKV C C Q C C+ G+ G C+ +D C N C H GTC
Sbjct: 1336 CHKKV--CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLP 1387
Query: 458 LEN-GLMCTCPAGFSGRRCEVRTSI-DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGS 515
+ C C G G C+ + + C + C + + L C C G+ G
Sbjct: 1388 INAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQP--YCECSSGYTGD 1445
Query: 516 RCE 518
C+
Sbjct: 1446 SCD 1448
Score = 33.1 bits (74), Expect = 0.88
Identities = 36/160 (22%), Positives = 51/160 (31%), Gaps = 65/160 (40%)
Query: 159 EQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRND----------HFGHYVCQPDG-NLS 207
E ST +Y +C Y G+ LC+++ D H + P G
Sbjct: 1008 ENNSTCVDGINNYTCLCPPEYTGE----LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCD 1063
Query: 208 CLPGWTGEYC-------QQPICLSGCH---EQNGY------------------------- 232
C PG+ GE+C Q C +G H NGY
Sbjct: 1064 CTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTS 1123
Query: 233 ------CSKPAECL---------CRPGWQGRLCNECIPHN 257
C A+C+ C PG+QG C + + N
Sbjct: 1124 PCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVN 1163
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 191 bits (486), Expect = 1e-48
Identities = 92/237 (38%), Positives = 116/237 (48%), Gaps = 14/237 (5%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCK---DQEDGYHC 348
SPCKN TC+ Y C C Y G DC + ++ C NPC++GG+C +DG+ C
Sbjct: 923 SPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSC 982
Query: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
CP G+ G CE + C D+ C N +C + NY C CPPN+TG C++ +D C
Sbjct: 983 SCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN--NYVCICPPNYTGELCDEVIDHCVP 1040
Query: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
N C + +C+ C C PG++G CE DC + C HG C D NG CTC
Sbjct: 1041 ELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTC 1100
Query: 467 PAGFSGRRCE-----VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
P GFSG CE V C C N A C T C CP GF G RCE
Sbjct: 1101 PQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT--CRCPPGFAGPRCE 1155
Score = 143 bits (360), Expect = 6e-34
Identities = 70/210 (33%), Positives = 102/210 (48%), Gaps = 8/210 (3%)
Query: 315 GYTGVDCELELSECDSNPCRNGGSC-KDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFN 373
G ++ + + C S+PC+N G+C +D + Y C CP Y G C +C +PC +
Sbjct: 907 GPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQH 966
Query: 374 GGSCRERNQGAN-YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGF 432
GG+C + + ++C CP F G CE D C N C N C++ + +C C P +
Sbjct: 967 GGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNY 1026
Query: 433 TGTYCELHVSDCAR--NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCF 490
TG C+ + C N C H C L+ G C C G+SG+ CE T D C + C
Sbjct: 1027 TGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE--TDNDDCVAHKCR 1084
Query: 491 NRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520
+ A C ++ + C CP GF G CE P
Sbjct: 1085 HGAQCVDTING--YTCTCPQGFSGPFCEHP 1112
Score = 112 bits (280), Expect = 1e-24
Identities = 65/220 (29%), Positives = 99/220 (45%), Gaps = 26/220 (11%)
Query: 207 SCLPGWTGEYCQQPI--CLSGCHEQNGYC------SKPAECLCRPGWQGRLC----NECI 254
+C + G+ C PI C+ + G C C C G++G+ C ++C
Sbjct: 942 ACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCE 1001
Query: 255 PHNGCRHGTCS---TPWQCTCDEGWGGLFCDQDLNYCTHH-SPCKNGATCSNSGQRSYTC 310
++ + TC + C C + G CD+ +++C + C++ A C + ++C
Sbjct: 1002 DNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPL-DKGFSC 1060
Query: 311 TCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEH-------ST 363
C PGY+G CE + +C ++ CR+G C D +GY C CP G+ G CEH T
Sbjct: 1061 ECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQT 1120
Query: 364 LSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV 403
C C NG C Q C CPP F G CEK +
Sbjct: 1121 SPCDQYECQNGAQCIVVQQEPT--CRCPPGFAGPRCEKLI 1158
Score = 72.4 bits (176), Expect = 1e-12
Identities = 46/129 (35%), Positives = 60/129 (46%), Gaps = 24/129 (18%)
Query: 220 PICLSGCHEQNGYCSKPAE----CLCRPGWQGRLCNE-----CIPHNGCRHGTC---STP 267
P C S ++G C + C CRPGW G LC++ C+ H C HG C T
Sbjct: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHGKCVATGTS 1388
Query: 268 WQCTCDEGWGGLFCD---QDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324
+ C C EG+GG CD N C+ C +G C S Q C C+PG++G C+ E
Sbjct: 1389 YMCKCAEGYGGDLCDNKNDSANACSAFK-CHHG-QCHISDQGEPYCLCQPGFSGEHCQQE 1446
Query: 325 LSECDSNPC 333
NPC
Sbjct: 1447 ------NPC 1449
Score = 68.6 bits (166), Expect = 2e-11
Identities = 53/169 (31%), Positives = 73/169 (43%), Gaps = 46/169 (27%)
Query: 170 SYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQ-QPICLSGCHE 228
+Y IC NY G+ LC + DH C P+ NL CQ + C+
Sbjct: 1017 NYVCICPPNYTGE----LCDEVIDH-----CVPELNL----------CQHEAKCIP---- 1053
Query: 229 QNGYCSKPAECLCRPGWQGRLC----NECIPHNGCRHGT----CSTPWQCTCDEGWGGLF 280
K C C PG+ G+LC ++C+ H CRHG + CTC +G+ G F
Sbjct: 1054 ----LDKGFSCECVPGYSGKLCETDNDDCVAHK-CRHGAQCVDTINGYTCTCPQGFSGPF 1108
Query: 281 CDQ-------DLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE 322
C+ + C + C+NGA C Q+ TC C PG+ G CE
Sbjct: 1109 CEHPPPMVLLQTSPCDQYE-CQNGAQCI-VVQQEPTCRCPPGFAGPRCE 1155
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/134 (29%), Positives = 56/134 (41%), Gaps = 28/134 (20%)
Query: 250 CNECIPHNGCRHGTCSTPWQ----CTCDEGWGGLFCDQD-----LNYCTHHSPCKNGATC 300
C C C+HG C + + C C GW G CDQ+ L + HH C T
Sbjct: 1332 CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGT- 1387
Query: 301 SNSGQRSYTCTCRPGYTGVDCELE---LSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGL 357
SY C C GY G C+ + + C + C +G + +CLC PG+ G
Sbjct: 1388 ------SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGE 1441
Query: 358 HCEHSTLSCADSPC 371
HC+ ++PC
Sbjct: 1442 HCQQ------ENPC 1449
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/119 (31%), Positives = 53/119 (44%), Gaps = 12/119 (10%)
Query: 406 CTSNPCANGGQCLN-RGPSRMCRCRPGFTGTYCELHVSDCARNPC----AHGGTCHDLEN 460
C S G C + S +C CRPG+TG C+ AR+PC H G C
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQE----ARDPCLGHRCHHGKCVATGT 1387
Query: 461 GLMCTCPAGFSGRRCEVRT-SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
MC C G+ G C+ + S +AC++ C + C+ + + C C GF G C+
Sbjct: 1388 SYMCKCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 17/123 (13%)
Query: 333 CRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERN---QGANYACE 389
C++G ++D C C PG+ G C+ A PC G C G +Y C+
Sbjct: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQE----ARDPCL-GHRCHHGKCVATGTSYMCK 1392
Query: 390 CPPNFTGSNCEKKVDR---CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCAR 446
C + G C+ K D C++ C +G ++ C C+PGF+G +C+
Sbjct: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------QE 1446
Query: 447 NPC 449
NPC
Sbjct: 1447 NPC 1449
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 482 DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
+AC SSPC N TC D + + C CPY + G C P+
Sbjct: 918 NACLSSPCKNNGTCTQD-PVELYRCACPYSYKGKDCTVPI 956
Score = 30.4 bits (67), Expect = 5.7
Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 25/104 (24%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNL---------SCLPGWTGEYCQQP----- 220
C Y G +LC+ ND + C+ +C G++G +C+ P
Sbjct: 1062 CVPGYSG----KLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVL 1117
Query: 221 ICLSGCHE---QNG----YCSKPAECLCRPGWQGRLCNECIPHN 257
+ S C + QNG + C C PG+ G C + I N
Sbjct: 1118 LQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVN 1161
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 184 bits (466), Expect = 3e-46
Identities = 91/236 (38%), Positives = 114/236 (48%), Gaps = 13/236 (5%)
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDG---YHC 348
SPC+N TC N Y C C GY G DCE+ L C S PC NGG+C QE + C
Sbjct: 932 SPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTC 991
Query: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
CP G+ G C +T C D C NGG C + NY C+CP + G CE+ VD C+
Sbjct: 992 SCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV--GNYTCQCPLQYEGKACEQLVDLCSP 1049
Query: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
NPC + QC+ C C PG+ G C + DC + C +G C D N C C
Sbjct: 1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLC 1109
Query: 467 PAGFSGRRCEVRTSIDA----CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
G+SG+ CE+ + A C + C N A C + VC C GF G CE
Sbjct: 1110 AEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRP--VCQCLPGFGGPECE 1163
Score = 155 bits (393), Expect = 9e-38
Identities = 82/247 (33%), Positives = 116/247 (46%), Gaps = 17/247 (6%)
Query: 250 CNECIPHNGCRHGTCSTP----WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC-SNSG 304
C+ C+ GTC ++C C G+ G C+ L+ C+ PC+NG TC + G
Sbjct: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS-GPCENGGTCHAQEG 984
Query: 305 QRS-YTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST 363
+ + +TC+C G+ G C + +C + C NGG C D Y C CP Y G CE
Sbjct: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
Query: 364 LSCAD--SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRG 421
C+ +PC + C G CEC P + G NC + D C + C NG QC++
Sbjct: 1045 DLCSPDLNPCQHEAQCVGTPDGPR--CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEV 1102
Query: 422 PSRMCRCRPGFTGTYCEL--HV----SDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRC 475
S C C G++G CE+ H+ S C C +G C D N +C C GF G C
Sbjct: 1103 NSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Query: 476 EVRTSID 482
E S++
Sbjct: 1163 EKLLSVN 1169
Score = 147 bits (371), Expect = 3e-35
Identities = 74/201 (36%), Positives = 99/201 (49%), Gaps = 8/201 (3%)
Query: 328 CDSNPCRNGGSC-KDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCR-ERNQGAN 385
C S+PC+N G+C D + Y C CP GY G CE S SC+ PC NGG+C + + A
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
Query: 386 YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA 445
+ C CP F G C D C + CANGG C++ + C+C + G CE V C+
Sbjct: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
Query: 446 R--NPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDT 503
NPC H C +G C C G++G C D C C N A C ++++
Sbjct: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQ--DDCRDHRCQNGAQCMDEVNS-- 1104
Query: 504 FVCNCPYGFVGSRCEFPVGLP 524
+ C C G+ G CE P LP
Sbjct: 1105 YSCLCAEGYSGQLCEIPPHLP 1125
Score = 136 bits (342), Expect = 7e-32
Identities = 78/242 (32%), Positives = 110/242 (45%), Gaps = 30/242 (12%)
Query: 221 ICLSGCHEQNGYC-SKPAE---CLCRPGWQGRLCNECIPHNGCRHGTCST---------- 266
+CLS + G C + P E C C G++GR C + + C G C
Sbjct: 928 LCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL--DSCSSGPCENGGTCHAQEGE 985
Query: 267 --PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE-- 322
P+ C+C G+ G C + + C H+ C NG C + G +YTC C Y G CE
Sbjct: 986 DAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCVD-GVGNYTCQCPLQYEGKACEQL 1043
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQ 382
++L D NPC++ C DG C C PGY G +C + C D C NG C + +
Sbjct: 1044 VDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMD--E 1101
Query: 383 GANYACECPPNFTGSNCE------KKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTY 436
+Y+C C ++G CE C C NG C+++G +C+C PGF G
Sbjct: 1102 VNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPE 1161
Query: 437 CE 438
CE
Sbjct: 1162 CE 1163
Score = 95.1 bits (235), Expect = 2e-19
Identities = 51/143 (35%), Positives = 65/143 (45%), Gaps = 13/143 (9%)
Query: 386 YACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM--CRCRPGFTGTYCELHVSD 443
+ C+ PP + K D C S+PC N G C N P + C C G+ G CE+ +
Sbjct: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHN-DPLEVYRCACPSGYKGRDCEVSLDS 967
Query: 444 CARNPCAHGGTCHDLEN---GLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS 500
C+ PC +GGTCH E C+CP GF G C V T D C C N C +
Sbjct: 968 CSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNT--DDCVDHACANGGVCVDGVG 1025
Query: 501 TDTFVCNCPYGFVGSRCEFPVGL 523
+ C CP + G CE V L
Sbjct: 1026 --NYTCQCPLQYEGKACEQLVDL 1046
Score = 71.2 bits (173), Expect = 3e-12
Identities = 43/119 (36%), Positives = 55/119 (46%), Gaps = 9/119 (7%)
Query: 259 CRHGTC---STPW-QCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRP 314
C HG C +TP C C+ GW GL CDQ + H C +G C SY+C C+
Sbjct: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQD 1405
Query: 315 GYTGVDCEL--ELSE-CDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP 370
GY+G C L+E C C +G G HC+C PG+ G CE + C P
Sbjct: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES-ECRGDP 1463
Score = 57.4 bits (137), Expect = 4e-08
Identities = 48/175 (27%), Positives = 66/175 (37%), Gaps = 34/175 (19%)
Query: 197 HYVCQPDGN----LSCLPGWTGEYCQQPICLSGCHEQ---NGYC----SKPAECLCRPGW 245
H +CQP+ C GW G +C QP CH +G C + C C+ G+
Sbjct: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQP-ADGPCHGHKCVHGQCVPLDALSYSCQCQDGY 1407
Query: 246 QGRLCNE----CIPHNG--CRHGTCSTPW----QCTCDEGWGGLFCDQDLNYCTHHSPCK 295
G LCN+ P G C HG C C CD G+ G C+Q+ S C+
Sbjct: 1408 SGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-------SECR 1460
Query: 296 NGATCS-NSGQRSYT-CTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC 348
+ QR Y C + V+C C C G K ++ + C
Sbjct: 1461 GDPVRDFHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLKRRKFTFEC 1512
Score = 56.6 bits (135), Expect = 7e-08
Identities = 38/129 (29%), Positives = 56/129 (43%), Gaps = 18/129 (13%)
Query: 332 PCRN----GGSCK-DQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERN----Q 382
PCR G C+ + G C C G+ GLHC+ AD PC +G C
Sbjct: 1341 PCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP----ADGPC-HGHKCVHGQCVPLD 1395
Query: 383 GANYACECPPNFTGSNCEKK---VDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCEL 439
+Y+C+C ++G+ C + + C C +G + C C PGF+G CE
Sbjct: 1396 ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE- 1454
Query: 440 HVSDCARNP 448
S+C +P
Sbjct: 1455 QESECRGDP 1463
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 6/94 (6%)
Query: 388 CECPPNFTGSNCEKKVDR-CTSNPCANGGQCLNRGP-SRMCRCRPGFTGTYCELH---VS 442
C C + G +C++ D C + C +G QC+ S C+C+ G++G C
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQAGALAE 1420
Query: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE 476
C C HG G C C GFSG CE
Sbjct: 1421 PCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/155 (29%), Positives = 54/155 (34%), Gaps = 55/155 (35%)
Query: 172 RVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG 231
R C Y GDNCS + D + CQ G C E N
Sbjct: 1068 RCECMPGYAGDNCS----ENQDDCRDHRCQ-----------NGAQCMD--------EVNS 1104
Query: 232 YCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHH 291
Y CLC G+ G+LC E PH C EG
Sbjct: 1105 Y-----SCLCAEGYSGQLC-EIPPHLPAPKSPC---------EG---------------- 1133
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELS 326
+ C+NGA C + G R C C PG+ G +CE LS
Sbjct: 1134 TECQNGANCVDQGNRP-VCQCLPGFGGPECEKLLS 1167
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 6/116 (5%)
Query: 406 CTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV-SDCARNPCAHGGTCHDLEN-GLM 463
C C +G N P MC C G+ G +C+ C + C H G C L+
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLDALSYS 1400
Query: 464 CTCPAGFSGRRCEVRTSI-DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C C G+SG C ++ + C C + C T C C GF G CE
Sbjct: 1401 CQCQDGYSGALCNQAGALAEPCRGLQCLH-GHCQAS-GTKGAHCVCDPGFSGELCE 1454
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/68 (36%), Positives = 34/68 (50%), Gaps = 9/68 (13%)
Query: 457 DLENGLMCTCPAGFSGRRCE------VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPY 510
D+E L+ T PA C+ V+ D C SSPC N+ TC+ D + + C CP
Sbjct: 898 DMEGKLLLTTPA--KKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHND-PLEVYRCACPS 954
Query: 511 GFVGSRCE 518
G+ G CE
Sbjct: 955 GYKGRDCE 962
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 160 bits (405), Expect = 4e-39
Identities = 102/305 (33%), Positives = 139/305 (45%), Gaps = 46/305 (15%)
Query: 221 ICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCR-HGTCSTPWQCTCDEGWGGL 279
IC C + C P C C+PG+ G C + C+ HG C P C C G GG
Sbjct: 1297 ICKYPCGKSRE-CVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGA 1355
Query: 280 FCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC 339
CD++ +C + PC++G TC CTC G+ G CE + C+ + C NGG C
Sbjct: 1356 TCDEE--HC--NPPCQHGGTCLAGN----LCTCPYGFVGPRCETMV--CNRH-CENGGQC 1404
Query: 340 KDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNC 399
+ C C PG+YG C ST C D C NGGSC + N C CP F G +C
Sbjct: 1405 LTPDI---CQCKPGWYGPTC--STALC-DPVCLNGGSCNKPN-----TCLCPNGFFGEHC 1453
Query: 400 EKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLE 459
+ PC NGG C+ + +C CR G+TG + + D C +GG C
Sbjct: 1454 QNAF---CHPPCKNGGHCMR---NNVCVCREGYTGRRFQKSICDPT---CMNGGKCVGPS 1504
Query: 460 NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF 519
C+CP+G+SG+RC + C N C +C+CP + G RC+
Sbjct: 1505 T---CSCPSGWSGKRCNTPICLQKCK-----NGGECIAPS-----ICHCPSSWEGVRCQI 1551
Query: 520 PVGLP 524
P+ P
Sbjct: 1552 PICNP 1556
Score = 159 bits (402), Expect = 8e-39
Identities = 109/336 (32%), Positives = 148/336 (44%), Gaps = 52/336 (15%)
Query: 184 CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRP 243
C C K + +C+ C PG+ G CQ +C C + +G C KP C C P
Sbjct: 1298 CKYPCGKSRECVAPNICK------CKPGYIGSNCQTALCDPDC-KNHGKCIKPNICQCLP 1350
Query: 244 GWQGRLCNECIPHNGCRH-GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSN 302
G G C+E + C+H GTC CTC G+ G C+ + C H C+NG C
Sbjct: 1351 GHGGATCDEEHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMV--CNRH--CENGGQCLT 1406
Query: 303 SGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHS 362
C C+PG+ G C L CD C NGGSC CLCP G++G HC++
Sbjct: 1407 PD----ICQCKPGWYGPTCSTAL--CDP-VCLNGGSCNKPNT---CLCPNGFFGEHCQN- 1455
Query: 363 TLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP 422
+ PC NGG C N C C +TG +K + T C NGG+C+ GP
Sbjct: 1456 --AFCHPPCKNGGHCMRNN-----VCVCREGYTGRRFQKSICDPT---CMNGGKCV--GP 1503
Query: 423 SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSID 482
S C C G++G C + C + C +GG C +C CP+ + G RC++
Sbjct: 1504 S-TCSCPSGWSGKRCNTPI--CLQK-CKNGGECIAPS---ICHCPSSWEGVRCQI----- 1551
Query: 483 ACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
P N Y VC+C + G +CE
Sbjct: 1552 -----PICNPKCLYGGRCIFPNVCSCRTEYSGVKCE 1582
Score = 129 bits (324), Expect = 9e-30
Identities = 88/267 (32%), Positives = 114/267 (42%), Gaps = 35/267 (13%)
Query: 175 CSDNYYGDNCSRL-CKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
C + G C C H G C +C G+ G C+ +C C E G C
Sbjct: 1348 CLPGHGGATCDEEHCNPPCQHGG--TCLAGNLCTCPYGFVGPRCETMVCNRHC-ENGGQC 1404
Query: 234 SKPAECLCRPGWQGRLCNECIPHNGCRH-GTCSTPWQCTCDEGWGGLFCDQDLNYCTHHS 292
P C C+PGW G C+ + C + G+C+ P C C G+ G C +C H
Sbjct: 1405 LTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQN--AFC--HP 1460
Query: 293 PCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP 352
PCKNG C R+ C CR GYTG + S CD C NGG C C CP
Sbjct: 1461 PCKNGGHC----MRNNVCVCREGYTG--RRFQKSICDPT-CMNGGKCVGPST---CSCPS 1510
Query: 353 GYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-C 411
G+ G C +T C C NGG C A C CP ++ G C+ + NP C
Sbjct: 1511 GWSGKRC--NTPICLQK-CKNGGECI-----APSICHCPSSWEGVRCQIPI----CNPKC 1558
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCE 438
GG+C+ +C CR ++G CE
Sbjct: 1559 LYGGRCIF---PNVCSCRTEYSGVKCE 1582
Score = 107 bits (268), Expect = 3e-23
Identities = 82/297 (27%), Positives = 107/297 (36%), Gaps = 83/297 (27%)
Query: 294 CKNGATCSNS-----GQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC 348
C NG +C + G Y C C PG+ G CE+++S C SNPC GS Y C
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPC-GLGSYISGFHSYSC 1241
Query: 349 LCPPGY--------------------------------------YGLHCEHSTLSCADSP 370
CPP + + + P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301
Query: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRP 430
C C N C+C P + GSNC+ + C + C N G+C+ +C+C P
Sbjct: 1302 CGKSRECVAPN-----ICKCKPGYIGSNCQTAL--CDPD-CKNHGKCIK---PNICQCLP 1350
Query: 431 GFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT----------- 479
G G C+ + PC HGGTC G +CTCP GF G RCE
Sbjct: 1351 GHGGATCD---EEHCNPPCQHGGTCLA---GNLCTCPYGFVGPRCETMVCNRHCENGGQC 1404
Query: 480 -SIDACASSPCFNRATCYTDLSTDTFV----------CNCPYGFVGSRCEFPVGLPP 525
+ D C P + TC T L + C CP GF G C+ PP
Sbjct: 1405 LTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPP 1461
Score = 97.8 bits (242), Expect = 3e-20
Identities = 87/348 (25%), Positives = 117/348 (33%), Gaps = 122/348 (35%)
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPG-------------- 315
C C G+ G C+ D++ C +PC G+ SG SY+C C P
Sbjct: 1204 CVCLPGFHGSLCEVDISGC-QSNPCGLGSYI--SGFHSYSCDCPPELKVETQFVNQFTTQ 1260
Query: 316 ---YTGVDCELELSECDSN---------------------PCRNGGSCKDQEDGYHCLCP 351
T D + E D N PC C C C
Sbjct: 1261 TVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYPCGKSRECVAPN---ICKCK 1317
Query: 352 PGYYGLHCE-------------------------HSTLSC----ADSPCFNGGSCRERNQ 382
PGY G +C+ H +C + PC +GG+C N
Sbjct: 1318 PGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTCLAGN- 1376
Query: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVS 442
C CP F G CE V + C NGGQCL +C+C+PG+ G C +
Sbjct: 1377 ----LCTCPYGFVGPRCETMV---CNRHCENGGQCLT---PDICQCKPGWYGPTCSTALC 1426
Query: 443 DCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE--------------VRTSIDAC---- 484
D C +GG+C+ C CP GF G C+ +R ++ C
Sbjct: 1427 DPV---CLNGGSCNKPNT---CLCPNGFFGEHCQNAFCHPPCKNGGHCMRNNVCVCREGY 1480
Query: 485 ---------ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGL 523
C N C C+CP G+ G RC P+ L
Sbjct: 1481 TGRRFQKSICDPTCMNGGKC-----VGPSTCSCPSGWSGKRCNTPICL 1523
Score = 79.0 bits (193), Expect = 1e-14
Identities = 47/154 (30%), Positives = 68/154 (44%), Gaps = 13/154 (8%)
Query: 174 ICSDNYYGDNCSR-LCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGY 232
+C + ++G++C C + GH C + C G+TG Q+ IC C G
Sbjct: 1443 LCPNGFFGEHCQNAFCHPPCKNGGH--CMRNNVCVCREGYTGRRFQKSICDPTCMN-GGK 1499
Query: 233 CSKPAECLCRPGWQGRLCNECIPHNGCRHG-TCSTPWQCTCDEGWGGLFCDQDLNYCTHH 291
C P+ C C GW G+ CN I C++G C P C C W G+ C + C +
Sbjct: 1500 CVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPSICHCPSSWEGVRCQ--IPIC--N 1555
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELEL 325
C G C C+CR Y+GV CE ++
Sbjct: 1556 PKCLYGGRCIFPN----VCSCRTEYSGVKCEKKI 1585
Score = 63.5 bits (153), Expect = 6e-10
Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 13/123 (10%)
Query: 174 ICSDNYYGDN-----CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHE 228
+C + Y G C C G C SC GW+G+ C PICL C +
Sbjct: 1475 VCREGYTGRRFQKSICDPTCMNGGKCVGPSTC------SCPSGWSGKRCNTPICLQKC-K 1527
Query: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHG-TCSTPWQCTCDEGWGGLFCDQDLNY 287
G C P+ C C W+G C I + C +G C P C+C + G+ C++ +
Sbjct: 1528 NGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCEKKIQI 1587
Query: 288 CTH 290
H
Sbjct: 1588 RRH 1590
Score = 29.6 bits (65), Expect = 9.7
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 5/51 (9%)
Query: 476 EVRTSIDACASS-PCFNRATCYTDLS----TDTFVCNCPYGFVGSRCEFPV 521
E R +I+ S C N +C +D + + ++C C GF GS CE +
Sbjct: 1169 ETRVTIEVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDI 1219
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 159 bits (403), Expect = 6e-39
Identities = 131/423 (30%), Positives = 154/423 (36%), Gaps = 100/423 (23%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTGEYCQQPI--------CLSG 225
C + YG NCS+ C F C P G C PGW G C Q C
Sbjct: 990 CPAHTYGHNCSQACAC----FNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHS 1045
Query: 226 CHEQNGYCSKPAE--CLCRPGWQGRLCN-ECIPHN---GCRH-------GTCST-PWQCT 271
C QNG P C C GW G C EC+P + GCRH G C +C
Sbjct: 1046 CLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCL 1105
Query: 272 CDEGWGGLFCDQDL------NYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE--- 322
C GW G C C C GA C + + C C PG+TG CE
Sbjct: 1106 CPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHV---TGACRCPPGFTGSGCEQAC 1162
Query: 323 ---------LELSECDS-----NPCRNGGSCKDQEDGYHCL--CPPGYYGLHCEHSTLSC 366
++ +C +P SC G C CPPG YG CE C
Sbjct: 1163 PPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQL---C 1219
Query: 367 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-------CANGGQCLN 419
C NGGSC A AC CP F G++C + P C G C
Sbjct: 1220 G---CLNGGSC----DAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC-- 1270
Query: 420 RGPSRMCRCRPGFTGTYCELHVSDCARN----------PCAHGGTCHDLENGLMCTCPAG 469
+ C C PG G CE C +N C +GG CH NG C+C G
Sbjct: 1271 DPVTGTCLCPPGRAGVRCE---RGCPQNRFGVGCEHTCSCRNGGLCH-ASNG-SCSCGLG 1325
Query: 470 FSGRRCEV-----RTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLP 524
++GR CE+ R C N +TC T C C GF G CE P P
Sbjct: 1326 WTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGT----CRCGPGFYGQACEHP--CP 1379
Query: 525 PSF 527
P F
Sbjct: 1380 PGF 1382
Score = 147 bits (372), Expect = 2e-35
Identities = 123/414 (29%), Positives = 158/414 (38%), Gaps = 95/414 (22%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTGEYCQQ--------PICLS 224
+C +YG +C C ND GH C P G+ SC PGWTG CQ+ P C
Sbjct: 816 VCPAGWYGPSCQTRCSCAND--GH--CHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSH 871
Query: 225 GCHEQNGYCSKPA---ECLCRPGWQGRLCNECIP--HNG--------CRHGTC--STPWQ 269
C+ G+ S A CLC G+ G C + P H G C+HG
Sbjct: 872 PCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGA 931
Query: 270 CTCDEGWGGLFCD------------QDLNYCTHHSPCK--NGATCSNSGQRSYTC--TCR 313
CTC GW G FC+ + CT + C NG+ +G+R C TC
Sbjct: 932 CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCP 991
Query: 314 PGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC-----------LCPPGYYGLHCEHS 362
G +C + C NG SC HC CP G YG +C HS
Sbjct: 992 AHTYGHNCS------QACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHS 1045
Query: 363 TLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK-VDRCTSNPCANGGQCLNRG 421
L C NGG+C + C CP + G CEK+ + R C + G CLN G
Sbjct: 1046 CL------CQNGGTC----DPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGG 1095
Query: 422 ----PSRMCRCRPGFTGTYCELHVSDCARN----------PCAHGGTCHDLENGLMCTCP 467
+ C C G+TG C+ S C R C G CH + C CP
Sbjct: 1096 LCDPHTGRCLCPAGWTGDKCQ---SPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCP 1150
Query: 468 AGFSGRRCEVRTSIDACASSPCFNRATCYTD---LSTDTFVCNCPYGFVGSRCE 518
GF+G CE + C C + T C+C G+ G C+
Sbjct: 1151 PGFTGSGCE-QACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQ 1203
Score = 131 bits (329), Expect = 2e-30
Identities = 120/416 (28%), Positives = 148/416 (35%), Gaps = 91/416 (21%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHY---------VCQPD-GNLSCLPGWTGEYCQQPICLS 224
C + + G C + C R+ G +C P G C GWTG+ CQ P CL
Sbjct: 1063 CPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSP-CLR 1121
Query: 225 G-----------------CHEQNGYCSKP-------AECLCRPGWQGRLCNE---CIPHN 257
G CH G C P E C PG G C + C N
Sbjct: 1122 GWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGEN 1181
Query: 258 GCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ---RSYTCTCRP 314
H T C+C G+ G C Q + C+ C N G + C C
Sbjct: 1182 PACHPATGT---CSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPT 1238
Query: 315 GYTGVDCELELSECDSNP-------CRNGGSCKDQEDGYHCLCPPGYYGLHCEHST---- 363
G+ G DC L + P C G +C D G CLCPPG G+ CE
Sbjct: 1239 GFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC-DPVTGT-CLCPPGRAGVRCERGCPQNR 1296
Query: 364 --LSCADS-PCFNGGSCRERNQGANYACECPPNFTGSNCEKKVD----------RCTSNP 410
+ C + C NGG C +N +C C +TG +CE C+
Sbjct: 1297 FGVGCEHTCSCRNGGLCH----ASNGSCSCGLGWTGRHCELACPPGRYGAACHLECS--- 1349
Query: 411 CANGGQCLNRGPSRMCRCRPGFTGTYCE------LHVSDCARNP-CAHGGTCHDLENGLM 463
C N C + CRC PGF G CE H + C C HG C +
Sbjct: 1350 CHNNSTC--EPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISG--R 1405
Query: 464 CTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTD--TFVCNCPYGFVGSRC 517
C CPAGF G CE R C R C D T +C CP G G+ C
Sbjct: 1406 CLCPAGFHGHFCE-RGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATC 1460
Score = 125 bits (315), Expect = 1e-28
Identities = 114/408 (27%), Positives = 148/408 (36%), Gaps = 82/408 (20%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTGEYCQQPICLS----GCHEQ 229
C +G NCS C G C G C PG TGE C+ GC E
Sbjct: 731 CPVGTFGVNCSSSCS-----CGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEI 785
Query: 230 NGYCSKPAEC-------LCRPGWQGRLCNECIPHNGCRHGTCST-------------PWQ 269
C A C LC PG+ G C + P G +C T
Sbjct: 786 CPACQHAARCDPETGACLCLPGFVGSRCQDVCPA-GWYGPSCQTRCSCANDGHCHPATGH 844
Query: 270 CTCDEGWGGLFCDQDLNY------CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
C+C GW G C + + C+H PC A + S C C GY G CE
Sbjct: 845 CSCAPGWTGFSCQRACDTGHWGPDCSH--PCNCSAGHGSCDAISGLCLCEAGYVGPRCEQ 902
Query: 324 ELSECDSNP-------CRNGGSCKDQEDGYHCLCPPGYYGLHCEHST------LSCADS- 369
+ + P C++G +C D G C CP G+ G CEH+ L C +
Sbjct: 903 QCPQGHFGPGCEQRCQCQHGAAC-DHVSGA-CTCPAGWRGTFCEHACPAGFFGLDCRSAC 960
Query: 370 PCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT-SNPCANGGQCLNRGPSR---- 424
C G +C N +C CP G C + T + C+ C N
Sbjct: 961 NCTAGAAC----DAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHG 1016
Query: 425 MCRCRPGFTGTYC------ELHVSDCARNP-CAHGGTCHDLENGLMCTCPAGFSGRRCEV 477
C C PG+ G C L+ +C + C +GGTC + C CP G++G CE
Sbjct: 1017 QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGH--CACPEGWAGLACEK 1074
Query: 478 ----RTSIDACA-SSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520
R C S C N C T C CP G+ G +C+ P
Sbjct: 1075 ECLPRDVRAGCRHSGGCLNGGLC----DPHTGRCLCPAGWTGDKCQSP 1118
Score = 117 bits (292), Expect = 5e-26
Identities = 123/417 (29%), Positives = 157/417 (37%), Gaps = 90/417 (21%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQN--GY 232
C ++G+ C++ C H+V G C PG+TG C+Q C G ++
Sbjct: 1119 CLRGWFGEACAQRCSCPPGAACHHVT---GACRCPPGFTGSGCEQA-CPPGSFGEDCAQM 1174
Query: 233 CSKPAE----------CLCRPGWQGRLCNECIPHN----GCRH-------GTC-STPWQC 270
C P E C C G+ G C + P GC G+C + C
Sbjct: 1175 CQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGAC 1234
Query: 271 TCDEGWGGLFCDQDLNY------CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELE 324
C G+ G C+ CTH C GA C + TC C PG GV CE
Sbjct: 1235 RCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPV---TGTCLCPPGRAGVRCERG 1291
Query: 325 LSE------CDSN-PCRNGGSCKDQED---------GYHC--LCPPGYYGLHCEHSTLSC 366
+ C+ CRNGG C G HC CPPG YG C H SC
Sbjct: 1292 CPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAAC-HLECSC 1350
Query: 367 AD-SPCFNG-GSCRERNQGANYACE--CPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP 422
+ S C G+CR ACE CPP F G+ C+ C C +G C P
Sbjct: 1351 HNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQ---GLCW---CQHGAPC---DP 1401
Query: 423 -SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCH---DLENGL-------MCTCPAGFS 471
S C C GF G +CE C P + G CH D + G +C CP G S
Sbjct: 1402 ISGRCLCPAGFHGHFCE---RGC--EPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRS 1456
Query: 472 GRRCEVRTSIDACASSPCFNRATC--YTDLSTDTFVCNCPYGFVGSRCE--FPVGLP 524
G C + S C C D + C+C G++G C P+ LP
Sbjct: 1457 GATCNLDCRRGQFGPS-CTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRLP 1512
Score = 104 bits (259), Expect = 3e-22
Identities = 111/404 (27%), Positives = 142/404 (35%), Gaps = 111/404 (27%)
Query: 172 RVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG 231
+ +C D+ +G +CS C C+ G +CL G G
Sbjct: 508 KFVCLDDSFGHDCSLTCDD---------CRNGG--TCLLGLDG----------------- 539
Query: 232 YCSKPAECLCRPGWQGRLCNECIPHN----------GCRH-GTC-STPWQCTCDEGWGGL 279
C C GW G +CNE P + C++ GTC S C C G G
Sbjct: 540 -------CDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGT 592
Query: 280 FCDQDLNYCTHHSPCKNGATCSNSGQ--RSY-TCTCRPGYTGVDCELEL----------S 326
C+ + C+ C+N G+ R Y C C PG G C L
Sbjct: 593 NCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSE 652
Query: 327 ECD-----SNPC--RNGG-SCKDQEDGYHCL--CPPGYYGLHCEHSTLSCADSPCFN-GG 375
EC + C R+G SCK G C C GY+G C + C + G
Sbjct: 653 ECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSG 712
Query: 376 SCRER----NQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPG 431
C +R QG + ECP G NC C PC G + CRC PG
Sbjct: 713 ECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCS-CGGAPC--------HGVTGQCRCPPG 763
Query: 432 FTGTYCELHVSDCARN-----------PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS 480
TG CE +DC C H C D E G C C GF G RC+
Sbjct: 764 RTGEDCE---ADCPEGRWGLGCQEICPACQHAARC-DPETG-ACLCLPGFVGSRCQ---- 814
Query: 481 IDACASS----PCFNRATCYTD--LSTDTFVCNCPYGFVGSRCE 518
D C + C R +C D T C+C G+ G C+
Sbjct: 815 -DVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQ 857
Score = 90.1 bits (222), Expect = 6e-18
Identities = 102/350 (29%), Positives = 126/350 (36%), Gaps = 94/350 (26%)
Query: 206 LSCLPGWTG----EYCQQPICLSGCHEQNGYC--SKPAECLCRPGWQGRLC----NECIP 255
L C GW E C C + G C C C PG+QG C +EC
Sbjct: 108 LRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRT 167
Query: 256 HN-GCRHGTCSTP--WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYT--- 309
HN GC+H +TP + C C G+ L D + NG + Q + T
Sbjct: 168 HNGGCQHRCVNTPGSYLCECKPGF-RLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHR 226
Query: 310 CTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADS 369
C CRPG+ + QEDG HC+ S
Sbjct: 227 CQCRPGF-----------------------QLQEDGRHCV-----------------RRS 246
Query: 370 PCFN-GGSCRERNQGAN--YACECPPNF----TGSNCEKKVDRCTSN--PCANGGQCLNR 420
PC N GSC R Q CEC + G CE VD C + CA+G CLN
Sbjct: 247 PCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE-DVDECAAGLAQCAHG--CLNT 303
Query: 421 GPSRMCRCRPGF----TGTYC---ELH-VSDCARN--PCAHGGTCHDLENGLMCTCPAGF 470
S C C G+ G C E+ V+ C N C+HG C G +CTCP G+
Sbjct: 304 QGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG--CSHTSAGPLCTCPRGY 361
Query: 471 SGRRCEVRTSIDA--CASSPCFNRAT----------CYTDLSTDTFVCNC 508
+ RT ID CA SPC + CY C C
Sbjct: 362 E-LDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 410
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/276 (27%), Positives = 113/276 (40%), Gaps = 51/276 (18%)
Query: 264 CSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
C W DE G L + + C H C G+ + C C PG+ G C+
Sbjct: 110 CCRGWMQQPDEE-GCLSAECSASLCFHGGRCVPGS--------AQPCHCPPGFQGPRCQY 160
Query: 324 ELSECDSNPCRNGG---SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE- 379
++ EC ++ NGG C + Y C C PG + LH + T +S G C+
Sbjct: 161 DVDECRTH---NGGCQHRCVNTPGSYLCECKPG-FRLHTDSRTCLAINSCALGNGGCQHH 216
Query: 380 --RNQGANYACECPPNF----TGSNCEKKVDRCTSNPCAN-GGQCLN-----RGPSRMCR 427
+ + C+C P F G +C ++ +PCAN G C++ RG +R C
Sbjct: 217 CVQLTITRHRCQCRPGFQLQEDGRHCVRR------SPCANRNGSCMHRCQVVRGLAR-CE 269
Query: 428 CRPGF----TGTYCELHVSDCARN--PCAHGGTCHDLENGLMCTCPAGF----SGRRCEV 477
C G+ G CE V +CA CAHG C + + C C AG+ GR+C
Sbjct: 270 CHVGYQLAADGKACE-DVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYELGADGRQC-Y 325
Query: 478 RTSIDACASSPCFNRATCYTDLSTDTF-VCNCPYGF 512
R ++ S N + T +C CP G+
Sbjct: 326 RIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGY 361
Score = 73.2 bits (178), Expect = 8e-13
Identities = 61/189 (32%), Positives = 81/189 (42%), Gaps = 34/189 (17%)
Query: 350 CPPGYYGLHCEHSTLS--CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCT 407
C G+ E LS C+ S CF+GG C G+ C CPP F G C+ VD C
Sbjct: 110 CCRGWMQQPDEEGCLSAECSASLCFHGGRCVP---GSAQPCHCPPGFQGPRCQYDVDECR 166
Query: 408 SNPCANGG---QCLNRGPSRMCRCRPGF---TGTYCELHVSDCARNPCAHGGTCHDLENG 461
++ NGG +C+N S +C C+PGF T + L ++ CA +GG H
Sbjct: 167 TH---NGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCA---LGNGGCQHHCVQL 220
Query: 462 LM----CTCPAGF----SGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
+ C C GF GR C VR S A + C +R L+ C C G+
Sbjct: 221 TITRHRCQCRPGFQLQEDGRHC-VRRSPCANRNGSCMHRCQVVRGLAR----CECHVGYQ 275
Query: 514 ----GSRCE 518
G CE
Sbjct: 276 LAADGKACE 284
Score = 33.1 bits (74), Expect = 0.88
Identities = 14/38 (36%), Positives = 21/38 (55%), Gaps = 3/38 (7%)
Query: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
C++S CF+ C + C+CP GF G RC++ V
Sbjct: 128 CSASLCFHGGRCVPGSAQP---CHCPPGFQGPRCQYDV 162
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 154 bits (389), Expect = 3e-37
Identities = 127/429 (29%), Positives = 165/429 (38%), Gaps = 87/429 (20%)
Query: 166 RLRYSYRVICSDNYY--GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ---- 219
R Y R C YY GD C LC + H C C PGW G C
Sbjct: 79 RTMYRRRSQCCPGYYESGDFCIPLC---TEECVHGRCVSPDTCHCEPGWGGPDCSSGCDS 135
Query: 220 ----PICLSGCHEQNGYCSKP--AECLCRPGWQGRLCNE-CIPHN---------GCRHGT 263
P C + C QNG P C+C G++G C E C P CRHG
Sbjct: 136 DHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGA 195
Query: 264 CSTP--WQCTCDEGWGGLFCDQ------DLNYCTHHSPCKNGATCSN-SGQRSYTCTCRP 314
P +C C G+ G++C++ +C PC+NG TC + +G+ C C P
Sbjct: 196 SCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGE----CACPP 251
Query: 315 GYTGVDCELEL------SECDSN-PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST---- 363
G+TG C C + PC +GG C D G C C GY G C+
Sbjct: 252 GWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC-DHVTG-QCHCTAGYMGDRCQEECPFGS 309
Query: 364 --LSCAD-SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV-------DRCT-SNPCA 412
C+ C NGG C ACEC P + G C++++ CT PC
Sbjct: 310 FGFQCSQHCDCHNGGQC----SPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCD 365
Query: 413 NGGQCLNRGPSRMCRCRPGFTGTYCEL-----HVSDCARNPCA--HGGTCHDLENGLMCT 465
+ C C+PG++G +C + D + PC +G CH + G CT
Sbjct: 366 ADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG--CT 423
Query: 466 CPAGFSGRRCEVRTSIDA----CAS-SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520
C GF G C V + C+S C N TC S C C G+ G C P
Sbjct: 424 CAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTC----SPVDGSCTCKEGWQGLDCTLP 479
Query: 521 VGLPPSFPW 529
PS W
Sbjct: 480 C---PSGTW 485
Score = 154 bits (388), Expect = 3e-37
Identities = 146/555 (26%), Positives = 205/555 (36%), Gaps = 145/555 (26%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ--------PICLSGC 226
C YYGD C C +N H + G +C PG+ GE C P C S C
Sbjct: 394 CPVGYYGDGCQLPCTCQNGADCHSIT---GGCTCAPGFMGEVCAVSCAAGTYGPNCSSIC 450
Query: 227 HEQNGYCSKPAE--CLCRPGWQGRLCN----------ECIPHNGCRHGTCSTP--WQCTC 272
NG P + C C+ GWQG C C C +G +P C+C
Sbjct: 451 SCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSC 510
Query: 273 DEGWGGLFCDQD-------LNYCTHHSPCKN--------GATCSNSGQRSYTC--TCRPG 315
GW G C+ LN C+ H C + G C +G C TC PG
Sbjct: 511 TPGWLGDTCELPCPDGTFGLN-CSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPG 569
Query: 316 YTGVDCELELSECDSNPCRNGGSCKDQEDGYHC-----------LCPPGYYG-------- 356
G +C + S C NGGSC ++ C +CPPG+YG
Sbjct: 570 RWGPNCSVSCS------CENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCP 623
Query: 357 --LH----CEHSTLSCADSPCFNGGSCRERNQGANY---------------------ACE 389
+H C H + C P F+G C + G + +C+
Sbjct: 624 LCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQ 683
Query: 390 CPPNFTGSNCEKKVDRCTSNP-------CANGGQCLNRGPSRMCRCRPGFTGTYCELHV- 441
C P + G +C + P C NG C C C PG+TG +C
Sbjct: 684 CFPGWIGKDCSQACPPGFWGPACFHACSCHNGASC--SAEDGACHCTPGWTGLFCTQRCP 741
Query: 442 -----SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVR----TSIDACAS-SPCF 490
DC R C +G +C + CTC GF+G+ CE R T C C
Sbjct: 742 AAFFGKDCGRVCQCQNGASCDHISG--KCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECM 799
Query: 491 NRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSF-PWVAVSLGVGL----------A 539
N +TC D T T C C GF G RC+ + P+ +S +G
Sbjct: 800 NNSTC--DHVTGT--CYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGI 855
Query: 540 VLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCG 599
+LL+ L +V + + RR + R+ +S PA ++ +T+ L CG
Sbjct: 856 MLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVS------YTPAMRMTSTDY--SLSGACG 907
Query: 600 LDKSNCGKQQNHTLD 614
+D+ +Q + +D
Sbjct: 908 MDR----RQNTYIMD 918
Score = 140 bits (354), Expect = 3e-33
Identities = 117/412 (28%), Positives = 154/412 (37%), Gaps = 90/412 (21%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPD-GNLSCLPGWTGEYCQQPICLSGCH----- 227
+C+ +G C C+ R+ C P G C PG+TG YC++ +C G H
Sbjct: 175 LCAPGTHGKGCQLPCQCRHGAS----CDPRAGECLCAPGYTGVYCEE-LCPPGSHGAHCE 229
Query: 228 -----EQNGYCSK-PAECLCRPGWQGRLC----------NECIPHNGCRH-GTCS-TPWQ 269
+ G C EC C PGW G +C C C H G C Q
Sbjct: 230 LRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQ 289
Query: 270 CTCDEGWGGLFCDQDLNY------CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
C C G+ G C ++ + C+ H C NG CS + + C C PGY G C+
Sbjct: 290 CHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPT---TGACECEPGYKGPRCQE 346
Query: 324 EL-------------SECDS------NPCRNGGSCKDQEDGYHC--LCPPGYYGLHCEHS 362
L CD+ +P +C+ G+HC CP GYYG C+
Sbjct: 347 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQ-- 404
Query: 363 TLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-------CANGG 415
L C C NG C G C C P F G C T P C NGG
Sbjct: 405 -LPCT---CQNGADCHSITGG----CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGG 456
Query: 416 QCLNRGPSRMCRCRPGFTGTYCELHVS------DCARN-PCAHGGTCHDLENGLMCTCPA 468
C S C C+ G+ G C L +C + CA+G C ++ C+C
Sbjct: 457 TCSPVDGS--CTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGS--CSCTP 512
Query: 469 GFSGRRCEVRTSIDACASSPCFNRATCYTDLSTD--TFVCNCPYGFVGSRCE 518
G+ G CE+ D C C D T C C G+ G RC+
Sbjct: 513 GWLGDTCELPCP-DGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCD 563
Score = 138 bits (347), Expect = 2e-32
Identities = 121/413 (29%), Positives = 157/413 (38%), Gaps = 92/413 (22%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQN--- 230
+C +G +C C +N H++ G +C PGWTG C QP C G QN
Sbjct: 218 LCPPGSHGAHCELRCPCQNGGTCHHIT---GECACPPGWTGAVCAQP-CPPGTFGQNCSQ 273
Query: 231 -------GYCSK-PAECLCRPGWQGRLCNE----------CIPHNGCRH-GTCS-TPWQC 270
G C +C C G+ G C E C H C + G CS T C
Sbjct: 274 DCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGAC 333
Query: 271 TCDEGWGGLFCDQDL-------NYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCEL 323
C+ G+ G C + L CT PC T S + CTC+PG++G C
Sbjct: 334 ECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTIS-CHPVTGACTCQPGWSGHHCN- 391
Query: 324 ELSECDSN----------PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--- 370
C C+NG C G C C PG+ G C S + P
Sbjct: 392 --ESCPVGYYGDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCS 447
Query: 371 ----CFNGG---------SCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQC 417
C NGG +C+E QG + CP G NC + CT CANG C
Sbjct: 448 SICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCN---ESCT---CANGAAC 501
Query: 418 LNRGPSRMCRCRPGFTGTYCELHVSD------CARN-PCAHGGTCHDLENGLMCTCPAGF 470
S C C PG+ G CEL D C+ + C+H C + C C AG+
Sbjct: 502 SPIDGS--CSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTG--HCCCLAGW 557
Query: 471 SGRRCEV-----RTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
+G RC+ R + S C N +C S + C C GF G C+
Sbjct: 558 TGIRCDSTCPPGRWGPNCSVSCSCENGGSC----SPEDGSCECAPGFRGPLCQ 606
Score = 128 bits (321), Expect = 2e-29
Identities = 121/454 (26%), Positives = 152/454 (33%), Gaps = 115/454 (25%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPI--------CLSGC 226
C +G NCS+ C H G G C G+ G+ CQ+ C C
Sbjct: 262 CPPGTFGQNCSQDCPC---HHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHC 318
Query: 227 HEQNGYCSKPAE--CLCRPGWQGRLCNECIPHNGCRHGTCSTP---------------WQ 269
NG P C C PG++G C E + G C+ P
Sbjct: 319 DCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGA 378
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQ-RSYT--CTCRPGYTGVDCELELS 326
CTC GW G C++ + C+ TC N S T CTC PG+ G C + +
Sbjct: 379 CTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCA 438
Query: 327 ECDSNP-------CRNGG---------SCKDQEDGYHCL--CPPGYYGLHCEHSTLSCAD 368
P C NGG +CK+ G C CP G +GL+C S +CA+
Sbjct: 439 AGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNES-CTCAN 497
Query: 369 ----SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVD-------------------- 404
SP SC G CP G NC + D
Sbjct: 498 GAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGW 557
Query: 405 ---RCTSN--------------PCANGGQCLNRGPSRMCRCRPGFTGTYCE------LHV 441
RC S C NGG C S C C PGF G C+ +
Sbjct: 558 TGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGS--CECAPGFRGPLCQRICPPGFYG 615
Query: 442 SDCAR--NPCAHGG-TCHDLENGLMCTCPAGFSGRRCEVRTS-----IDACASSPCFNRA 493
CA+ C H CH + +C C GFSG C + D C N
Sbjct: 616 HGCAQPCPLCVHSSRPCHHISG--ICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNG 673
Query: 494 TCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSF 527
TC S C C G++G C PP F
Sbjct: 674 TC----SPIDGSCQCFPGWIGKDCS--QACPPGF 701
Score = 100 bits (250), Expect = 3e-21
Identities = 67/207 (32%), Positives = 89/207 (42%), Gaps = 48/207 (23%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTGEYCQQPICLSGCHEQNGY 232
+C+ Y+G +C++LC N+ C P DG+ C PGW G+ C Q
Sbjct: 653 VCAGGYFGQDCAQLCSCANNG----TCSPIDGSCQCFPGWIGKDCSQA------------ 696
Query: 233 CSKPAECLCRPGWQGRLC-NECIPHNGCRHGTCSTP-WQCTCDEGWGGLFCDQDL----- 285
C PG+ G C + C HNG +CS C C GW GLFC Q
Sbjct: 697 --------CPPGFWGPACFHACSCHNGA---SCSAEDGACHCTPGWTGLFCTQRCPAAFF 745
Query: 286 -NYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSE------CDS-NPCRNGG 337
C C+NGA+C + S CTCR G+TG CE + C C N
Sbjct: 746 GKDCGRVCQCQNGASCDHI---SGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNS 802
Query: 338 SCKDQEDGYHCLCPPGYYGLHCEHSTL 364
+C D G C C PG+ G+ C+ + L
Sbjct: 803 TC-DHVTG-TCYCSPGFKGIRCDQAAL 827
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 149 bits (376), Expect = 8e-36
Identities = 154/568 (27%), Positives = 210/568 (36%), Gaps = 133/568 (23%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTGEYCQQPICLSG-------- 225
C YG NCS C +ND VC P DG+ +C GW G C C SG
Sbjct: 443 CPLGTYGINCSSRCGCKNDA----VCSPVDGSCTCKAGWHGVDCSIR-CPSGTWGFGCNL 497
Query: 226 -CHEQNGYCSKPAE--CLCRPGWQGRLCN----------ECIPHNGCRH--GTCSTPWQC 270
C NG + C C PGW+G C C C H G T C
Sbjct: 498 TCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHC 557
Query: 271 TCDEGWGGLFCDQDLNY------CTHHSPCKNGATCSNS--------GQRSYTCT--CRP 314
C GW G+ CD C+ CKNGA+CS G R TC C P
Sbjct: 558 RCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSP 617
Query: 315 GYTGVDCELELSEC--DSNPCRNGGSCKDQEDGY-----HCLCPPGYYGLHCEHSTLSCA 367
G+ G C +C S PC + D G+ + +CP G +G +C
Sbjct: 618 GFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC------AG 671
Query: 368 DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-------CANGGQCLNR 420
C N G+C ++ +C+C P + GS+C + P C NG C
Sbjct: 672 ICTCTNNGTCNPIDR----SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC--S 725
Query: 421 GPSRMCRCRPGFTGTYCE------LHVSDCAR-NPCAHGGTCHDLENGLMCTCPAGFSGR 473
C+C PG+TG YC + DCA C +G C + CTC GF GR
Sbjct: 726 AYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG--QCTCRTGFMGR 783
Query: 474 RCEVR----TSIDACAS-SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE---------- 518
CE + T C C N +TC D T T C C G+ G+RC+
Sbjct: 784 HCEQKCPSGTYGYGCRQICDCLNNSTC--DHITGT--CYCSPGWKGARCDQAGVIIVGNL 839
Query: 519 -----FPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNL-- 571
LP + G+ + VL+VL ++A+ + ++ + S A+
Sbjct: 840 NSLSRTSTALPADSYQIGAIAGIIILVLVVLF-LLALFIIYRHKQKGKESSMPAVTYTPA 898
Query: 572 -----SDFQKDNLIPAAQLKN------TNQKKELEVDCGL-------DKSNCGKQQNHTL 613
+D+ +P + N TN C D+ K +N+ L
Sbjct: 899 MRVVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQL 958
Query: 614 DYNL------APGPLG--RGTMPGKFPH 633
NL GP+G GT+P + H
Sbjct: 959 FVNLKNVNPGKRGPVGDCTGTLPADWKH 986
Score = 139 bits (350), Expect = 9e-33
Identities = 118/374 (31%), Positives = 146/374 (39%), Gaps = 80/374 (21%)
Query: 208 CLPGW--TGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCN----------ECIP 255
C PG+ +GE C P C C +G C P C C PGW G C+ C
Sbjct: 94 CCPGFYESGEMCV-PHCADKC--VHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTS 150
Query: 256 HNGCRHGTCSTP--WQCTCDEGWGGLFCDQDL------NYCTHHSPCKNGATCSN-SGQR 306
C++G P C C G+ G C+ N C C+NGATC + +G+
Sbjct: 151 RCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE- 209
Query: 307 SYTCTCRPGYTGVDCE------LELSECDSN-PCRNGGSCKDQEDGYHCLCPPGYYGLHC 359
C C PGYTG CE +C+ PC+NGG C C CP G+ G C
Sbjct: 210 ---CRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVC 264
Query: 360 EHST------LSCA-DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP-- 410
+C+ + C NGG+C A C C P +TG C+ D C
Sbjct: 265 GQPCPEGRFGKNCSQECQCHNGGTC----DAATGQCHCSPGYTGERCQ---DECPVGTYG 317
Query: 411 --CANGGQCLNRGP----SRMCRCRPGFTGTYCE-------LHVSDC-ARNPCAHGGT-- 454
CA QC+N G S C C GF G CE L+ C R PC T
Sbjct: 318 VLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHS 377
Query: 455 CHDLENGLMCTCPAGFSGRRCEVRTSI----DACAS-SPCFNRATCYTDLSTDTFVCNCP 509
CH + C C G+SG C S +AC C N A C + T C C
Sbjct: 378 CHPMSG--ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADC----DSVTGKCTCA 431
Query: 510 YGFVGSRCEFPVGL 523
GF G C P L
Sbjct: 432 PGFKGIDCSTPCPL 445
Score = 139 bits (349), Expect = 1e-32
Identities = 117/397 (29%), Positives = 152/397 (38%), Gaps = 105/397 (26%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQP--------ICLSGC 226
C + +G NCS+ C+ N G G C PG+TGE CQ +C C
Sbjct: 268 CPEGRFGKNCSQECQCHN---GGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETC 324
Query: 227 HEQNG---YCSKPAECLCRPGWQG-----RLCNE----------CIPHNGCRHGTCSTPW 268
NG Y A CLC G+ G RLC E C H H
Sbjct: 325 QCVNGGKCYHVSGA-CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSG 383
Query: 269 QCTCDEGWGGLFCDQDLN------YCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCE 322
+C C GW GL+C++ + C C+NGA C + + CTC PG+ G+DC
Sbjct: 384 ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGK---CTCAPGFKGIDC- 439
Query: 323 LELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCAD----SPCFNGGSCR 378
S P CP G YG++C S C + SP +C+
Sbjct: 440 -------STP-----------------CPLGTYGINCS-SRCGCKNDAVCSPVDGSCTCK 474
Query: 379 ERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCE 438
G + + CP G C + C NGG C + C C PG+ G CE
Sbjct: 475 AGWHGVDCSIRCPSGTWGFGCN------LTCQCLNGGACNTLDGT--CTCAPGWRGEKCE 526
Query: 439 LHVSD------CA-RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACA------ 485
L D CA R C+H CH C C G+SG C+ CA
Sbjct: 527 LPCQDGTYGLNCAERCDCSHADGCHPTTG--HCRCLPGWSGVHCD-----SVCAEGRWGP 579
Query: 486 --SSPCF--NRATCYTDLSTDTFVCNCPYGFVGSRCE 518
S PC+ N A+C S D +C C GF G+ C+
Sbjct: 580 NCSLPCYCKNGASC----SPDDGICECAPGFRGTTCQ 612
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/229 (32%), Positives = 101/229 (44%), Gaps = 51/229 (22%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFG--HYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQN- 230
ICS +YG CS+ C + G H++ G CLPG+TG C + +C SG +N
Sbjct: 614 ICSPGFYGHRCSQTCPQCVHSSGPCHHIT---GLCDCLPGFTGALCNE-VCPSGRFGKNC 669
Query: 231 -GYCS-------KPAE--CLCRPGWQGRLCNE----------CIPHNGCRHGTCSTPW-- 268
G C+ P + C C PGW G C++ CI C +G + +
Sbjct: 670 AGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG 729
Query: 269 QCTCDEGWGGLFCDQ--DLNY----CTHHSPCKNGATCSN-SGQRSYTCTCRPGYTGVDC 321
+C C GW GL+C Q L + C C+NGA C + SGQ CTCR G+ G C
Sbjct: 730 ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQ----CTCRTGFMGRHC 785
Query: 322 ELELSECDSNP----CRNGGSCKDQEDGYH----CLCPPGYYGLHCEHS 362
E +C S CR C + H C C PG+ G C+ +
Sbjct: 786 E---QKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 149 bits (375), Expect = 1e-35
Identities = 127/442 (28%), Positives = 176/442 (39%), Gaps = 77/442 (17%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTG----EYCQQPICLSGCHE 228
+C D +YG +C C +H C P +G SCLPGW G E C Q GC E
Sbjct: 349 LCPDGFYGLSCQAPCTCDREH--SLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQE 406
Query: 229 Q-----NGYCSKPAE-CLCRPGWQGRLCNECIPHN----------GCRHGTCSTP--WQC 270
G C + C C PG+ G C P + C + +P +C
Sbjct: 407 HCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGEC 466
Query: 271 TCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG---QRSYTCTCRPGYTGVDCELELSE 327
C EGW C T C C++ ++ CTC PG+ G C+L +
Sbjct: 467 VCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPK 526
Query: 328 CD-SNPCRNGGSCKDQEDGY-----HCLCPPGYYGLHCEHST------LSCADS-PCFNG 374
C + C D DG C C G+ G C S ++C+++ C NG
Sbjct: 527 GQFGEGCASRCDC-DHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNG 585
Query: 375 GSCRERNQGANYACECPPNFTGSNCEKKVD------RCTSNPCANGGQCLNRGPSR-MCR 427
G+C N C C P F G +C++ RC CAN C PS C
Sbjct: 586 GTCLPENGN----CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC---HPSNGTCY 638
Query: 428 CRPGFTGTYCELHV------SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT- 479
C G+TG C +CA+ C HGGTCH + C CP G++G C
Sbjct: 639 CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLGWTGHHCLEGCP 696
Query: 480 --SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF----PVGLPPSFPWVAVS 533
+ A S PC + +T C CP G G+ C P + P+ P S
Sbjct: 697 LGTFGANCSQPC--QCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNS 754
Query: 534 LG--VGLAVL-LVLLGMVAVAV 552
LG +G+AVL +++ +VA+ +
Sbjct: 755 LGAVIGIAVLGSLVVALVALFI 776
Score = 129 bits (325), Expect = 7e-30
Identities = 105/388 (27%), Positives = 147/388 (37%), Gaps = 87/388 (22%)
Query: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ--PI------CLSGC 226
C + ++G NCS+ C+ N G + G C PG+TG+ C++ P+ C C
Sbjct: 263 CPEGFHGPNCSQECRCHN---GGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETC 319
Query: 227 HEQNGYCSKPAE--CLCRPGWQGRLCNECIPHNGCRHGTCSTPW---------------Q 269
PA CLC G+ G C + + +G +C P +
Sbjct: 320 DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE 379
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG---QRSYTCTCRPGYTGVDCELELS 326
C+C GW GL C++ TH C+ C + G S C C PGYTG C
Sbjct: 380 CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCA---- 435
Query: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC----ADSPCFNGGSCRERNQ 382
LCPP YG++C + SC A SP C+E Q
Sbjct: 436 ---------------------SLCPPDTYGVNCS-ARCSCENAIACSPIDGECVCKEGWQ 473
Query: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV- 441
N + CPP G +C S CA+ C + + C C PG+ G +C+L
Sbjct: 474 RGNCSVPCPPGTWGFSCN------ASCQCAHEAVCSPQ--TGACTCTPGWHGAHCQLPCP 525
Query: 442 -----SDCA-RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT-----SIDACASSPCF 490
CA R C H C + C C AG+ G RC + ++ + C
Sbjct: 526 KGQFGEGCASRCDCDHSDGCDPVHG--RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK 583
Query: 491 NRATCYTDLSTDTFVCNCPYGFVGSRCE 518
N TC + C C GF G C+
Sbjct: 584 NGGTCLPENGN----CVCAPGFRGPSCQ 607
Score = 122 bits (307), Expect = 8e-28
Identities = 119/456 (26%), Positives = 154/456 (33%), Gaps = 126/456 (27%)
Query: 172 RVICSDNYYGDN--CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ--------PI 221
R+ C +Y C LC + H C C+PGW G+ C P
Sbjct: 87 RLQCCHGFYESRGFCVPLCAQECVHGR---CVAPNQCQCVPGWRGDDCSSECAPGMWGPQ 143
Query: 222 C--------LSGCHEQNGYCS-----KPAECL--CRPGWQGRLCN--------ECIPHNG 258
C S C ++G CS +P CL C PG+ G C C P G
Sbjct: 144 CDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTG 203
Query: 259 ----------------CRHGTC----------------STP-WQCTCDEGWGGLFCDQDL 285
C GT TP C+C GW G C
Sbjct: 204 ACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPC 263
Query: 286 NYCTHHSPCKNGATCSNSG---QRSYTCTCRPGYTGVDCELE----------LSECDSNP 332
H C C N G + + C C PGYTG C E CD P
Sbjct: 264 PEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAP 323
Query: 333 ---C--RNGGS-CKDQEDGYHC---LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQG 383
C NG C+ G C LCP G+YGL C+ +PC
Sbjct: 324 DARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ--------APCTCDREHSLSCHP 375
Query: 384 ANYACECPPNFTGSNCEKKVDRCTSNP-------CANGGQCLNRGPSRMCRCRPGFTGTY 436
N C C P + G +C + + T P C +GG C + S +C+C PG+TG +
Sbjct: 376 MNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPH 433
Query: 437 C-------ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV-----RTSIDAC 484
C V+ AR C + C ++ C C G+ C V
Sbjct: 434 CASLCPPDTYGVNCSARCSCENAIACSPIDG--ECVCKEGWQRGNCSVPCPPGTWGFSCN 491
Query: 485 ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFP 520
AS C + A C S T C C G+ G+ C+ P
Sbjct: 492 ASCQCAHEAVC----SPQTGACTCTPGWHGAHCQLP 523
Score = 104 bits (260), Expect = 2e-22
Identities = 99/339 (29%), Positives = 124/339 (36%), Gaps = 66/339 (19%)
Query: 215 EYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDE 274
++ Q+ C G +E G+C LC EC+ HG C P QC C
Sbjct: 83 DHRQRLQCCHGFYESRGFCVP----LC--------AQECV------HGRCVAPNQCQCVP 124
Query: 275 GWGGLFCDQDLN------------YCTHHSPC--KNGATCSNSGQRSYTC--TCRPGYTG 318
GW G C + C ++S C K+G SG + C C PGY G
Sbjct: 125 GWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYG 184
Query: 319 VDCELELSECDSNPC--RNGGS-CKDQEDGYHC--LCPPGYYGLHCEHSTLSCADSPCF- 372
C+ +C PC + G C + G C C G G C ST SC + F
Sbjct: 185 PACQFR-CQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP-STHSCQNGGVFQ 242
Query: 373 ---NGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCR 429
SC G + CP F G NC ++ C NGG C + CRC
Sbjct: 243 TPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQEC------RCHNGGLCDRF--TGQCRCA 294
Query: 430 PGFTGTYCELHV------SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSID 482
PG+TG C DCA CA C NG C C GF+G RC R D
Sbjct: 295 PGYTGDRCREECPVGRFGQDCAETCDCAPDARCFP-ANG-ACLCEHGFTGDRCTDRLCPD 352
Query: 483 ACASSPCFNRATCYTDLSTDTF----VCNCPYGFVGSRC 517
C TC + S C+C G+ G C
Sbjct: 353 GFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 391
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 145 bits (365), Expect = 2e-34
Identities = 78/204 (38%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 310 CTCRPGYTGVDCELELSECDSNPCRNGGSCKDQE--DGYHCLCPPGYYGLHCEHSTLS-- 365
C C G+ G C+ C+ N C+NGG+C Q C C G+ G C++ST
Sbjct: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
Query: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM 425
PC NGG+C ++ Y C C FTG C+ D C S+PCANG C
Sbjct: 71 FVSRPCLNGGTCHMLSRDT-YECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFS 128
Query: 426 CRCRPGFTGTYCELHVSDC-ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
C+C GFTG CE V++C C HGGTC +L C C GF+G+ C+ + C
Sbjct: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD--SLYVPC 186
Query: 485 ASSPCFNRATCYTDLSTDTFVCNC 508
A SPC N TC TF CNC
Sbjct: 187 APSPCVNGGTC-RQTGDFTFECNC 209
Score = 141 bits (355), Expect = 2e-33
Identities = 78/197 (39%), Positives = 98/197 (49%), Gaps = 22/197 (11%)
Query: 270 CTCDEGWGGLFCDQDLNYCTHHSPCK-----NGATC-SNSGQRSYTCTCRPGYTGVDCEL 323
C C EG+ G YC H PC+ NG TC + + TC C G+TG DC+
Sbjct: 12 CKCPEGFLG-------EYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY 64
Query: 324 ELSE--CDSNPCRNGGSCKD-QEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE- 379
S S PC NGG+C D Y C C G+ G C+ T +C PC NG +C
Sbjct: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTV 123
Query: 380 RNQGANYACECPPNFTGSNCEKKVDRCT-SNPCANGGQCLNRGPSRMCRCRPGFTGTYCE 438
NQ ++C+C FTG CE V+ C C +GG CLN S C+C GFTG YC+
Sbjct: 124 ANQ---FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
Query: 439 LHVSDCARNPCAHGGTC 455
CA +PC +GGTC
Sbjct: 181 SLYVPCAPSPCVNGGTC 197
Score = 123 bits (309), Expect = 5e-28
Identities = 73/216 (33%), Positives = 96/216 (44%), Gaps = 22/216 (10%)
Query: 227 HEQNGYCSKPAECLCRPGWQGRLCNECIP--HNGCRHG-TCSTPWQ-----CTCDEGWGG 278
H GYC C G+ G C P N C++G TC C C G+ G
Sbjct: 6 HNGTGYCK------CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
Query: 279 LFCDQDLNY-CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGG 337
C ++ C PC NG TC + +Y CTC+ G+TG +C+ C S+PC NG
Sbjct: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGS 118
Query: 338 SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--CFNGGSCRERNQGANYACECPPNFT 395
+C + + C C G+ G CE C D P C +GG+C N +Y C+C FT
Sbjct: 119 TCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCL--NLPGSYQCQCLQGFT 175
Query: 396 GSNCEKKVDRCTSNPCANGGQCLNRGPSRM-CRCRP 430
G C+ C +PC NGG C G C C P
Sbjct: 176 GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
Score = 121 bits (304), Expect = 2e-27
Identities = 70/206 (33%), Positives = 100/206 (48%), Gaps = 21/206 (10%)
Query: 204 GNLSCLPGWTGEYCQ-QPICLSGCHEQNGYCSKPA-----ECLCRPGWQGRLC-----NE 252
G C G+ GEYCQ + C + G C A C C G+ G C +
Sbjct: 10 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
Query: 253 CIPHNGCRHG-TCST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRS 307
C C +G TC ++CTC G+ G C Q + C H PC NG+TC+ +
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCTTVANQ- 126
Query: 308 YTCTCRPGYTGVDCELELSECD-SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
++C C G+TG CE +++ECD C++GG+C + Y C C G+ G +C+ + C
Sbjct: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
Query: 367 ADSPCFNGGSCRERNQGANYACECPP 392
A SPC NGG+CR+ + C C P
Sbjct: 187 APSPCVNGGTCRQTGD-FTFECNCLP 211
Score = 114 bits (286), Expect = 2e-25
Identities = 61/177 (34%), Positives = 85/177 (48%), Gaps = 12/177 (6%)
Query: 347 HCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDR- 405
+C CP G+ G +C+H C + C NGG+C + C C FTG +C+
Sbjct: 11 YCKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
Query: 406 -CTSNPCANGGQC--LNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGL 462
S PC NGG C L+R C C+ GFTG C+ C +PCA+G TC + N
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYE-CTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQF 127
Query: 463 MCTCPAGFSGRRCEVRTSIDAC-ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
C C GF+G++CE T ++ C C + TC ++ C C GF G C+
Sbjct: 128 SCKCLTGFTGQKCE--TDVNECDIPGHCQHGGTCLN--LPGSYQCQCLQGFTGQYCD 180
Score = 110 bits (274), Expect = 6e-24
Identities = 60/150 (40%), Positives = 74/150 (49%), Gaps = 12/150 (8%)
Query: 377 CRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP--SRMCRCRPGFTG 434
C + G Y C+CP F G C+ + D C N C NGG C+ + CRC GFTG
Sbjct: 2 CVTYHNGTGY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
Query: 435 TYCELHVSD--CARNPCAHGGTCHDLENGLM-CTCPAGFSGRRCEVRTSIDACASSPCFN 491
C+ S PC +GGTCH L CTC GF+G+ C+ DAC S PC N
Sbjct: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT---DACLSHPCAN 116
Query: 492 RATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
+TC T + F C C GF G +CE V
Sbjct: 117 GSTCTT--VANQFSCKCLTGFTGQKCETDV 144
Score = 48.5 bits (114), Expect = 2e-05
Identities = 24/71 (33%), Positives = 28/71 (39%), Gaps = 4/71 (5%)
Query: 455 CHDLENGL-MCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
C NG C CP GF G C+ R D C + C N TC C C GF
Sbjct: 2 CVTYHNGTGYCKCPEGFLGEYCQHR---DPCEKNRCQNGGTCVAQAMLGKATCRCASGFT 58
Query: 514 GSRCEFPVGLP 524
G C++ P
Sbjct: 59 GEDCQYSTSHP 69
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 137 bits (346), Expect = 3e-32
Identities = 107/350 (30%), Positives = 144/350 (41%), Gaps = 66/350 (18%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
+C + + G++CS L ND F C +G C G+TGE C +P C CH Q G C
Sbjct: 300 VCDEGFTGEDCSELICP-NDCFDRGRCI-NGTCYCEEGFTGEDCGKPTCPHACHTQ-GRC 356
Query: 234 SKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDL--NYCTHH 291
+ +C+C G+ G C+E C + +C CD+G+ G C + N C+ H
Sbjct: 357 EE-GQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGH 415
Query: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
C NG C C GYTG DC C N C + G C + + C+C
Sbjct: 416 GRCVNGQ-----------CVCDEGYTGEDCSQ--LRCP-NDCHSRGRCVEGK----CVCE 457
Query: 352 PGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPC 411
G+ G C S +SC + C + + N C C +TG +C DR C
Sbjct: 458 QGFKGYDC--SDMSCPND-------CHQHGRCVNGMCVCDDGYTGEDCR---DRQCPRDC 505
Query: 412 ANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPC---AHG-GTCHDLENGLMCTCP 467
+N G C++ C C GFTG DCA C HG G C NG C C
Sbjct: 506 SNRGLCVDG----QCVCEDGFTGP-------DCAELSCPNDCHGQGRC---VNG-QCVCH 550
Query: 468 AGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
GF G+ C+ + S C + C C C GF G C
Sbjct: 551 EGFMGKDCK-----EQRCPSDCHGQGRCVDG------QCICHEGFTGLDC 589
Score = 135 bits (339), Expect = 2e-31
Identities = 108/370 (29%), Positives = 146/370 (39%), Gaps = 74/370 (20%)
Query: 174 ICSDNYYGDNCSRL-CKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGY 232
IC D + G++CS+L C + G V +G C G+ G C + IC C E++G
Sbjct: 206 ICDDGFTGEDCSQLACPSDCNDQGKCV---NGVCICFEGYAGADCSREICPVPCSEEHGT 262
Query: 233 CSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDL--NYCTH 290
C C+C G+ G CN+ + N C + +C CDEG+ G C + + N C
Sbjct: 263 CVDGL-CVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFD 321
Query: 291 HSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLC 350
C NG TC C G+TG DC + C G C++ + C+C
Sbjct: 322 RGRCING-----------TCYCEEGFTGEDCG---KPTCPHACHTQGRCEEGQ----CVC 363
Query: 351 PPGYYGLHCE--------HSTLSCADSPC-----FNGGSCRE---------RNQGANYAC 388
G+ G+ C H+ C D C F G C E + N C
Sbjct: 364 DEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQC 423
Query: 389 ECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA-RN 447
C +TG +C + RC N C + G+C+ C C GF G C SD + N
Sbjct: 424 VCDEGYTGEDCSQL--RC-PNDCHSRGRCV----EGKCVCEQGFKGYDC----SDMSCPN 472
Query: 448 PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCN 507
C G C NG MC C G++G C D C NR C C
Sbjct: 473 DCHQHGRC---VNG-MCVCDDGYTGEDCR-----DRQCPRDCSNRGLCVDG------QCV 517
Query: 508 CPYGFVGSRC 517
C GF G C
Sbjct: 518 CEDGFTGPDC 527
Score = 119 bits (298), Expect = 9e-27
Identities = 100/351 (28%), Positives = 128/351 (36%), Gaps = 79/351 (22%)
Query: 200 CQPDGNLS-------CLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNE 252
C GN S C PGW G C +P C CH G C +C+C G+ G C++
Sbjct: 161 CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCH-LRGRCI-DGQCICDDGFTGEDCSQ 218
Query: 253 CIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPC-KNGATCSNSGQRSYTCT 311
+ C C C EG+ G C +++ C PC + TC + C
Sbjct: 219 LACPSDCNDQGKCVNGVCICFEGYAGADCSREI--CP--VPCSEEHGTCVDG-----LCV 269
Query: 312 CRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPC 371
C G+ G DC L N C N G C + E C+C G+ G C S L C + C
Sbjct: 270 CHDGFAGDDCNKPLC---LNNCYNRGRCVENE----CVCDEGFTGEDC--SELICPND-C 319
Query: 372 FNGGSCRERNQGANYACECPPNFTGSNCEKKV--------DRCTSNPCANG--------- 414
F+ G C N C C FTG +C K RC C
Sbjct: 320 FDRGRC------INGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Query: 415 -----GQCLNRG--PSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCP 467
C NRG C C GFTG +DC C +G + H C C
Sbjct: 374 EKRCPADCHNRGRCVDGRCECDDGFTG-------ADCGELKCPNGCSGHGRCVNGQCVCD 426
Query: 468 AGFSGRRC-EVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
G++G C ++R D C +R C C C GF G C
Sbjct: 427 EGYTGEDCSQLRCPND------CHSRGRCVEG------KCVCEQGFKGYDC 465
Score = 56.6 bits (135), Expect = 7e-08
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 4/110 (3%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
+C D + G +C+ L ND G C +G C G+ G+ C++ C S CH Q G C
Sbjct: 517 VCEDGFTGPDCAELSCP-NDCHGQGRCV-NGQCVCHEGFMGKDCKEQRCPSDCHGQ-GRC 573
Query: 234 SKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQ 283
+C+C G+ G C + + C + +C C+EG+ G C +
Sbjct: 574 VD-GQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSE 622
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/139 (30%), Positives = 55/139 (39%), Gaps = 30/139 (21%)
Query: 388 CECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARN 447
C C P + G NC + C N C G+C++ C C GFTG DC++
Sbjct: 174 CVCEPGWKGPNCSEP--ECPGN-CHLRGRCIDG----QCICDDGFTG-------EDCSQL 219
Query: 448 PCAHGGTCHD---LENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTF 504
C C+D NG+ C C G++G C S + C TC L
Sbjct: 220 ACP--SDCNDQGKCVNGV-CICFEGYAGADC----SREICPVPCSEEHGTCVDGL----- 267
Query: 505 VCNCPYGFVGSRCEFPVGL 523
C C GF G C P+ L
Sbjct: 268 -CVCHDGFAGDDCNKPLCL 285
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 4/82 (4%)
Query: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
+C + + G +C + +D G C DG C G+TG C Q C S C+ G C
Sbjct: 548 VCHEGFMGKDCKEQ-RCPSDCHGQGRCV-DGQCICHEGFTGLDCGQHSCPSDCNNL-GQC 604
Query: 234 SKPAECLCRPGWQGRLCNECIP 255
C+C G+ G C+E P
Sbjct: 605 VS-GRCICNEGYSGEDCSEVSP 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.472
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,065,047
Number of Sequences: 37866
Number of extensions: 1933700
Number of successful extensions: 13595
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 219
Number of HSP's that attempted gapping in prelim test: 3913
Number of HSP's gapped (non-prelim): 3021
length of query: 685
length of database: 18,247,518
effective HSP length: 109
effective length of query: 576
effective length of database: 14,120,124
effective search space: 8133191424
effective search space used: 8133191424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.