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Search of human proteins with 90421316
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
(613 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 1241 0.0
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 1241 0.0
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 1241 0.0
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 339 4e-93
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 339 4e-93
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 335 9e-92
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 189 8e-48
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 189 8e-48
gi|21614542 single-minded homolog 1 [Homo sapiens] 187 2e-47
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 168 1e-41
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 163 5e-40
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 162 8e-40
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 105 9e-23
gi|4758010 clock [Homo sapiens] 103 6e-22
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 97 6e-20
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 94 3e-19
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 93 6e-19
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 93 6e-19
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 92 1e-18
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 92 1e-18
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 92 1e-18
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 87 6e-17
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 79 2e-14
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 68 3e-11
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 68 3e-11
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 68 3e-11
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 64 5e-10
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 63 7e-10
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 63 7e-10
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 51 3e-06
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 1241 bits (3210), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
Query: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG
Sbjct: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
Query: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR
Sbjct: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
Query: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL
Sbjct: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
Query: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE
Sbjct: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
Query: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP
Sbjct: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
Query: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG
Sbjct: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
Query: 601 GPFQPRAGSAQAD 613
GPFQPRAGSAQAD
Sbjct: 601 GPFQPRAGSAQAD 613
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 1241 bits (3210), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH
Sbjct: 55 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 114
Query: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG
Sbjct: 115 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 174
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL
Sbjct: 175 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 234
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK
Sbjct: 235 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 294
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT
Sbjct: 295 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 354
Query: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR
Sbjct: 355 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 414
Query: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL
Sbjct: 415 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 474
Query: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE
Sbjct: 475 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 534
Query: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP
Sbjct: 535 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 594
Query: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG
Sbjct: 595 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 654
Query: 601 GPFQPRAGSAQAD 613
GPFQPRAGSAQAD
Sbjct: 655 GPFQPRAGSAQAD 667
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 1241 bits (3210), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH
Sbjct: 57 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 116
Query: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG
Sbjct: 117 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 176
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL
Sbjct: 177 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 236
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK
Sbjct: 237 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 296
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT
Sbjct: 297 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 356
Query: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR
Sbjct: 357 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 416
Query: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL
Sbjct: 417 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 476
Query: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE
Sbjct: 477 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 536
Query: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP
Sbjct: 537 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 596
Query: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG
Sbjct: 597 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 656
Query: 601 GPFQPRAGSAQAD 613
GPFQPRAGSAQAD
Sbjct: 657 GPFQPRAGSAQAD 669
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 339 bits (870), Expect = 4e-93
Identities = 161/301 (53%), Positives = 220/301 (73%), Gaps = 2/301 (0%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
MRLTISYLR+ +L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K+
Sbjct: 60 MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY 119
Query: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
+GL+Q EL GHS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRG
Sbjct: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG 179
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
RT+N+K+ATWKVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL
Sbjct: 180 RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPL 237
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
FLSRHSLDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +K
Sbjct: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQ TGQYR LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QT
Sbjct: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
Query: 301 E 301
E
Sbjct: 358 E 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 320 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 379
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 380 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 433
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 434 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 493
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 494 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 544
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 339 bits (870), Expect = 4e-93
Identities = 161/301 (53%), Positives = 220/301 (73%), Gaps = 2/301 (0%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
MRLTISYLR+ +L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K+
Sbjct: 60 MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY 119
Query: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
+GL+Q EL GHS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRG
Sbjct: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG 179
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
RT+N+K+ATWKVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL
Sbjct: 180 RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPL 237
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
FLSRHSLDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +K
Sbjct: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQ TGQYR LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QT
Sbjct: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
Query: 301 E 301
E
Sbjct: 358 E 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 320 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 379
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 380 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 433
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 434 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 493
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 494 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 544
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 335 bits (858), Expect = 9e-92
Identities = 199/492 (40%), Positives = 285/492 (57%), Gaps = 50/492 (10%)
Query: 1 MRLTISYLRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVS 58
MRL IS+LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+S
Sbjct: 57 MRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENIS 116
Query: 59 KHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTL 116
K +GL+Q+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+
Sbjct: 117 KFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTV 176
Query: 117 TSRGRTLNLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGS 175
T+RGRT+NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP
Sbjct: 177 TNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSH 234
Query: 176 LEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH 235
++ PL FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS
Sbjct: 235 MDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQ 294
Query: 236 TLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVL 295
L +KGQ V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV
Sbjct: 295 NLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVF 354
Query: 296 SLEQTEQHSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTP 328
S++QTE + + +GA S+K P PGD++ +
Sbjct: 355 SMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISL 414
Query: 329 GPRILAFLHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATR 382
F + +A L A + R + L + A +TP AT
Sbjct: 415 DFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATS 474
Query: 383 HPQSPLSADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAP 436
S + + P++ +N + +LF DTEA + D + LDLE LAP
Sbjct: 475 SSSSCSTPNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAP 531
Query: 437 YISMD-DDFQLN 447
YI MD +DFQL+
Sbjct: 532 YIPMDGEDFQLS 543
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 189 bits (479), Expect = 8e-48
Identities = 116/310 (37%), Positives = 170/310 (54%), Gaps = 17/310 (5%)
Query: 1 MRLTISYLRMHRLCAAG---EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDM 50
+RLT SYL+M + G W Q G PLD L+ L+GFV V+ ++G +
Sbjct: 43 IRLTTSYLKMRAVFPEGLGDAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKI 101
Query: 51 AYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFS 109
Y+SE S HLGLSQ+EL G+SI+++IHP D +E+ LT Q L + E ER F
Sbjct: 102 MYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFF 161
Query: 110 LRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEA 169
LRMK L R L + +KV++CSG+++ + S DS + LV + ++
Sbjct: 162 LRMKCVLAKRNA--GLTCSGYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQS 216
Query: 170 IPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDA 229
+P E L F+ R SLD+K + D R+ EV GY P DLI + Y ++H D
Sbjct: 217 LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
Query: 230 VSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE 289
+ + H LL KGQ T YR L++ GG++W Q+ ATVV R + IV V+++++++E
Sbjct: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
Query: 290 ETGVVLSLEQ 299
+ LSLEQ
Sbjct: 337 YKELQLSLEQ 346
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 189 bits (479), Expect = 8e-48
Identities = 116/310 (37%), Positives = 170/310 (54%), Gaps = 17/310 (5%)
Query: 1 MRLTISYLRMHRLCAAG---EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDM 50
+RLT SYL+M + G W Q G PLD L+ L+GFV V+ ++G +
Sbjct: 43 IRLTTSYLKMRAVFPEGLGDAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKI 101
Query: 51 AYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFS 109
Y+SE S HLGLSQ+EL G+SI+++IHP D +E+ LT Q L + E ER F
Sbjct: 102 MYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFF 161
Query: 110 LRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEA 169
LRMK L R L + +KV++CSG+++ + S DS + LV + ++
Sbjct: 162 LRMKCVLAKRNA--GLTCSGYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQS 216
Query: 170 IPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDA 229
+P E L F+ R SLD+K + D R+ EV GY P DLI + Y ++H D
Sbjct: 217 LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
Query: 230 VSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE 289
+ + H LL KGQ T YR L++ GG++W Q+ ATVV R + IV V+++++++E
Sbjct: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
Query: 290 ETGVVLSLEQ 299
+ LSLEQ
Sbjct: 337 YKELQLSLEQ 346
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 187 bits (476), Expect = 2e-47
Identities = 114/309 (36%), Positives = 165/309 (53%), Gaps = 15/309 (4%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMA 51
+RLT SYL+M + G G G L + L+ L+GF+ V+ +G +
Sbjct: 43 IRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIM 102
Query: 52 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSL 110
Y+SE S HLGLSQ+EL G+SI+++IHP D +E+ LT Q V E ER F L
Sbjct: 103 YISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFL 162
Query: 111 RMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAI 170
RMK L R L +KV++CSG+++ + SP D LV + ++
Sbjct: 163 RMKCVLAKRNA--GLTCGGYKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSL 217
Query: 171 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 230
P E L F+ R SLDMK + D R+AE+ GY P DLI + Y ++H D+ +
Sbjct: 218 PPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHL 277
Query: 231 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEE 290
+ H LL KGQ T YRFLA+ GG++W Q+ AT+V R + IV V+++++ E
Sbjct: 278 RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEY 337
Query: 291 TGVVLSLEQ 299
G+ LSL+Q
Sbjct: 338 KGLQLSLDQ 346
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 168 bits (426), Expect = 1e-41
Identities = 114/389 (29%), Positives = 190/389 (48%), Gaps = 71/389 (18%)
Query: 1 MRLTISYLRMHRLCAAGE--WNQVGAGGEP------------------------LDACYL 34
+RLTISYL+M G+ WN G P L + L
Sbjct: 64 IRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHIL 123
Query: 35 KALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL----- 89
++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 124 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP 183
Query: 90 -------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRG 120
+ Q+ + VE+ + ER F +RMKSTLT RG
Sbjct: 184 PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG 243
Query: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
+++K++ +KV++ +G +R + S + + LV++ A+P P E +
Sbjct: 244 --VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRI 296
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL+K
Sbjct: 297 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 356
Query: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
GQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + + Q
Sbjct: 357 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 416
Query: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPG 329
++ + S + + + DS DT G
Sbjct: 417 PHLP----EKTSESSETSDSESDSKDTSG 441
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 163 bits (412), Expect = 5e-40
Identities = 100/330 (30%), Positives = 172/330 (52%), Gaps = 45/330 (13%)
Query: 34 LKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---- 89
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
Query: 90 --------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSR 119
+ Q+ + VE+ + ER F +RMKSTLT R
Sbjct: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
Query: 120 GRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPP 179
G +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 262 G--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVR 314
Query: 180 LGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS 239
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL+
Sbjct: 315 IDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLN 374
Query: 240 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 299
KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + + Q
Sbjct: 375 KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQ 434
Query: 300 TEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 329
++ + S + + + DS DT G
Sbjct: 435 LPHLP----EKTSESSETSDSESDSKDTSG 460
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 162 bits (410), Expect = 8e-40
Identities = 117/395 (29%), Positives = 183/395 (46%), Gaps = 82/395 (20%)
Query: 1 MRLTISYLRMHRLCAAGE--WNQVGAGG--------------------EPLDACYLKALE 38
+RL+++YLR+ R A G W AG + L L++L+
Sbjct: 88 VRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLD 147
Query: 39 GFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------- 89
GFV L EG Y+SE VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 148 GFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGP 207
Query: 90 ------------------TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAA 128
TP+ S KV + ER F +RMKSTLT RG L++KA+
Sbjct: 208 PTPPSVSSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKAS 265
Query: 129 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 188
+KV++ +G +RA+ LV + +P E PL + R
Sbjct: 266 GYKVIHVTGRLRAHALG-----------------LVALGHTLPPAPLAELPLHGHMIVFR 308
Query: 189 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 248
SL + C+ R+++ P +L+G S Y+++H D+ + +S LL KGQ +TG Y
Sbjct: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYY 368
Query: 249 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQ 299
R+L R+GG++W Q+ ATV G+ P ++ V ++SQ E + ++ E+
Sbjct: 369 RWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEE 428
Query: 300 TEQHSRRPIQRGAPSQ--KDTPNPGDSLDTPGPRI 332
P + P++ + P ++ T G RI
Sbjct: 429 ASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRI 463
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 105 bits (263), Expect = 9e-23
Identities = 92/311 (29%), Positives = 144/311 (46%), Gaps = 38/311 (12%)
Query: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCD----------- 81
LK EGF+ V+ E G + ++S++VSK L Q L G S+FDF+HP D
Sbjct: 187 LKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSF 246
Query: 82 ----QEELQDALTPQQTLS-----RRKVEAPTERCFSLRMKSTLTS----RGRTLNLKAA 128
+E+L DA T Q S R +V + + R F R+KS S G N K
Sbjct: 247 DISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKK 306
Query: 129 TWK---VLNCSGHMRAYKPP--AQTSPAGSPDSEPPLQCLVLICEAIPH---PGSLEPPL 180
+ ++C+G++R++ P S CLV I P+ S E +
Sbjct: 307 EHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV 366
Query: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALD-SDAVSKSIHTLLS 239
F++R +++ KF Y D R + GY P +L+G S YEY H D ++ K L S
Sbjct: 367 KPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQS 426
Query: 240 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETG----VVL 295
K + +T Y+F A+ G ++ ++Q + + E IV V+ L+ E G +
Sbjct: 427 KEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPC 486
Query: 296 SLEQTEQHSRR 306
S + +E+ SR+
Sbjct: 487 SSQSSEESSRQ 497
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 103 bits (256), Expect = 6e-22
Identities = 85/338 (25%), Positives = 148/338 (43%), Gaps = 51/338 (15%)
Query: 1 MRLTISYLRMHRLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAY 52
++ +I +LR H+ A +W E L+AL+GF + + +G + Y
Sbjct: 74 LQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIY 133
Query: 53 LSENVSKHLGLSQLELIGHSIFDFIHPCDQEEL----------QDALTPQQTLSRRKVEA 102
+SE+V+ L +L+ SIF+FI + E+ D+LTP+ S+ ++E
Sbjct: 134 VSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLE- 192
Query: 103 PTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAG---------S 153
F M RG + +T++ + G+ ++ + ++ G
Sbjct: 193 -----FCCHML-----RGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHR 242
Query: 154 PDSEPPLQCLVLICEAIPH----PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYS 209
P E + + + A P ++E P F SRHSL+ KF + D R + GY
Sbjct: 243 PSYEDRVCFVATVRLATPQFIKEMCTVEEP--NEEFTSRHSLEWKFLFLDHRAPPIIGYL 300
Query: 210 PDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSG 269
P +++G S Y+Y H D + ++K L+ G+ + YRFL + ++W QT +
Sbjct: 301 PFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH 360
Query: 270 GRGPQSESIVCVHFLISQVE-------ETGVVLSLEQT 300
+ E IVC H ++S E E G+ SL +T
Sbjct: 361 QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPET 398
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 96.7 bits (239), Expect = 6e-20
Identities = 91/378 (24%), Positives = 160/378 (42%), Gaps = 73/378 (19%)
Query: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTA 46
+R+ +S+++ R G G + D Y L+A +GF+ V+ A
Sbjct: 106 LRMAVSHMKSMR----------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155
Query: 47 E-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT 104
E G + Y+S++V+ L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215
Query: 105 ------------------ERCFSLRMK--------------STLTSRGRT----LNLKAA 128
R F RM+ +T+ R R + A
Sbjct: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275
Query: 129 TWKVLNCSGHMRAYKPPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRG 183
+ V++C+G+++A+ P T P D + CLV I + P +
Sbjct: 276 QYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPT 335
Query: 184 AFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQ 242
FLSRH+ D T+ D R V GY P DL+G E+ H D + +S ++ KGQ
Sbjct: 336 EFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQ 395
Query: 243 AVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQ 302
++ YRF ++ ++ +T + + E I+C + + Q+++ L E
Sbjct: 396 VLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EV 450
Query: 303 HSRRPIQRGAPSQKDTPN 320
H R + SQ PN
Sbjct: 451 HQRDGLSSYDLSQVPVPN 468
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 94.4 bits (233), Expect = 3e-19
Identities = 98/400 (24%), Positives = 165/400 (41%), Gaps = 38/400 (9%)
Query: 18 EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFI 77
+W E L+AL+GF++ +T +G + Y+S++++ LG +++ ++ +F+
Sbjct: 74 DWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFL 133
Query: 78 HPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 137
+ E+ L+ ++ + L L RG + T++ + G
Sbjct: 134 PEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEFPTYEYIKFVG 192
Query: 138 HMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAIPHPGSLEPPLGRGA 184
+ R+Y S G + S P PL C + + + ++ PL
Sbjct: 193 NFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEE-- 250
Query: 185 FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV 244
F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +++ L+ G+
Sbjct: 251 FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGK 310
Query: 245 TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE---ETGVVLSLEQTE 301
+ YRFL + ++W QT + + E IVC H ++S + E L+LE
Sbjct: 311 SCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPP 370
Query: 302 Q---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDL 358
HS +G S + ++LD G L H PS S + S
Sbjct: 371 SEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSRSSHKSSHTAMSE-- 425
Query: 359 RRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 398
P + A STP P SA LP ELPV
Sbjct: 426 -----PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 93.2 bits (230), Expect = 6e-19
Identities = 76/330 (23%), Positives = 149/330 (45%), Gaps = 48/330 (14%)
Query: 1 MRLTISYLRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSE 55
+R+ +S+++ R G + + L L+A +GF+ +++ E G + Y+S+
Sbjct: 117 LRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSD 176
Query: 56 NVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT---------- 104
+V+ L Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 177 SVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS 236
Query: 105 --------ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGH 138
R F RM+ +S R R N + + V++C+G+
Sbjct: 237 SMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGY 296
Query: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDM 193
++A+ P + P P++ + CLV I + P+ + F+SRH+++
Sbjct: 297 IKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEG 356
Query: 194 KFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLA 252
FT+ D R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +
Sbjct: 357 IFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRS 416
Query: 253 RSGGYLWTQTQATVVSGGRGPQSESIVCVH 282
++ +LW +T + + E I+C +
Sbjct: 417 KNQEWLWMRTSSFTFQNPYSDEIEYIICTN 446
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 93.2 bits (230), Expect = 6e-19
Identities = 76/330 (23%), Positives = 149/330 (45%), Gaps = 48/330 (14%)
Query: 1 MRLTISYLRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSE 55
+R+ +S+++ R G + + L L+A +GF+ +++ E G + Y+S+
Sbjct: 132 LRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSD 191
Query: 56 NVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT---------- 104
+V+ L Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 192 SVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS 251
Query: 105 --------ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGH 138
R F RM+ +S R R N + + V++C+G+
Sbjct: 252 SMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGY 311
Query: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDM 193
++A+ P + P P++ + CLV I + P+ + F+SRH+++
Sbjct: 312 IKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEG 371
Query: 194 KFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLA 252
FT+ D R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +
Sbjct: 372 IFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRS 431
Query: 253 RSGGYLWTQTQATVVSGGRGPQSESIVCVH 282
++ +LW +T + + E I+C +
Sbjct: 432 KNQEWLWMRTSSFTFQNPYSDEIEYIICTN 461
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQ 92
L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+FD++HP D ++++ L+
Sbjct: 109 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 168
Query: 93 QTLSR-RKVEAPT-------------------ERCFSLRMKSTLTSRG-------RTLNL 125
T R R ++A T R F RMK S T +
Sbjct: 169 DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK 228
Query: 126 KA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----LQCLVLI----CEAIPHPG 174
K ++ ++ +G+++++ P T D+EP L CLV I +P P
Sbjct: 229 KKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPV 285
Query: 175 SLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSI 234
+ E + ++SRH++D KF + D R + Y P +L+G S YEY H D +++
Sbjct: 286 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 345
Query: 235 HTLLSKGQAVTGQ-YRFLARSGGYL 258
+L + +T Y+F + G ++
Sbjct: 346 RQVLQTREKITTNCYKFKIKDGSFI 370
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQ 92
L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+FD++HP D ++++ L+
Sbjct: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
Query: 93 QTLSR-RKVEAPT-------------------ERCFSLRMKSTLTSRG-------RTLNL 125
T R R ++A T R F RMK S T +
Sbjct: 212 DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK 271
Query: 126 KA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----LQCLVLI----CEAIPHPG 174
K ++ ++ +G+++++ P T D+EP L CLV I +P P
Sbjct: 272 KKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPV 328
Query: 175 SLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSI 234
+ E + ++SRH++D KF + D R + Y P +L+G S YEY H D +++
Sbjct: 329 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 388
Query: 235 HTLLSKGQAVTGQ-YRFLARSGGYL 258
+L + +T Y+F + G ++
Sbjct: 389 RQVLQTREKITTNCYKFKIKDGSFI 413
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQ 92
L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+FD++HP D ++++ L+
Sbjct: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
Query: 93 QTLSR-RKVEAPT-------------------ERCFSLRMKSTLTSRG-------RTLNL 125
T R R ++A T R F RMK S T +
Sbjct: 212 DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK 271
Query: 126 KA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----LQCLVLI----CEAIPHPG 174
K ++ ++ +G+++++ P T D+EP L CLV I +P P
Sbjct: 272 KKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPV 328
Query: 175 SLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSI 234
+ E + ++SRH++D KF + D R + Y P +L+G S YEY H D +++
Sbjct: 329 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 388
Query: 235 HTLLSKGQAVTGQ-YRFLARSGGYL 258
+L + +T Y+F + G ++
Sbjct: 389 RQVLQTREKITTNCYKFKIKDGSFI 413
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 86.7 bits (213), Expect = 6e-17
Identities = 109/416 (26%), Positives = 169/416 (40%), Gaps = 51/416 (12%)
Query: 2 RLTISYLRMHRL-CAAGEWNQVGAGGEPLDAC-----------YLKALEGFVMVLTAEGD 49
++ +SYL + L C AGG PL + AL GF++V TAEG
Sbjct: 34 KVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGK 93
Query: 50 MAYLSENVSKHLGLSQLELI--GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERC 107
+ YLSE+VS+HLG S ++L+ G SI+D I P D ++ LT L T+R
Sbjct: 94 LLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALD-------TDRL 146
Query: 108 FSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLIC 167
F R ++ ++L ++A K++ G A+ P A AG+P L
Sbjct: 147 FRCRFNTS-----KSLRRQSAGNKLVLIRGRFHAHPPGAYW--AGNPVFTAFCAPLEPRP 199
Query: 168 EAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDS 227
P PG L F SRH+ D+ + + G+ +L+ S Y +H D
Sbjct: 200 RPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDL 259
Query: 228 DAVSKSIHTLLSKGQAVTGQ--YRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLI 285
S + LL++ + + R A++GG+ W G GP I ++ I
Sbjct: 260 AHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYC-LLYSEGPEGP----ITANNYPI 314
Query: 286 SQVEETGVVLSLEQTEQHSRRPIQRGAP-----------SQKD--TPNPGDSLDTPGPRI 332
S +E + L + + + G P SQ++ + NP + PR
Sbjct: 315 SDMEAWSLRQQLNSEDTQAAYVL--GTPTMLPSFPENILSQEECSSTNPLFTAALGAPRS 372
Query: 333 LAFLHPPSLSEAALAAD-PRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSP 387
+F P LS + + + PR D L P S+ A S L P +P
Sbjct: 373 TSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 78.6 bits (192), Expect = 2e-14
Identities = 68/262 (25%), Positives = 114/262 (43%), Gaps = 38/262 (14%)
Query: 34 LKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQD----AL 89
L+AL GFV+V+T + + Y S + +LG Q ++I S+++ IH D+ E Q AL
Sbjct: 119 LQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWAL 178
Query: 90 TPQQ-TLSRRKVEAPT----------------------ERCFSLRMKSTLTSRGRTLNLK 126
P Q T S + +E T ERCF R++ L +
Sbjct: 179 NPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDN-------- 230
Query: 127 AATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFL 186
++ + +N G ++ + GS PP L I + P LE F
Sbjct: 231 SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILPPQLALFAIATPLQPPSILEIRTKNFIFR 288
Query: 187 SRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCSAYEYIHALDSDAVSKSIHTLLSKGQAVT 245
++H LD CD + V GY+ +L S Y++IHA D ++S ++ G++
Sbjct: 289 TKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGM 348
Query: 246 GQYRFLARSGGYLWTQTQATVV 267
+R L ++ + W Q+ A ++
Sbjct: 349 IVFRLLTKNNRWTWVQSNARLL 370
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+ S++ +H D E
Sbjct: 110 ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFV 169
Query: 87 DALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNLKAA-TWKVLNCSGHMRA 141
L P+ ++ ++ F+ RM T N +A ++V+ C
Sbjct: 170 KNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCF----- 224
Query: 142 YKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDR 201
+ D E CL+ I +P P ++ G +F+++ K D
Sbjct: 225 ---TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTS 278
Query: 202 IAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 258
AG + +DL+ Y + + + ++++G A + YRF+ G L
Sbjct: 279 SLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTML 338
Query: 259 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDT 318
T+ + I+ +H I E +G+ Q + +S I R PS +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDDTNSGMSIPRVNPSVNPS 393
Query: 319 PNP 321
+P
Sbjct: 394 ISP 396
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+ S++ +H D E
Sbjct: 110 ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFV 169
Query: 87 DALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNLKAA-TWKVLNCSGHMRA 141
L P+ ++ ++ F+ RM T N +A ++V+ C
Sbjct: 170 KNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCF----- 224
Query: 142 YKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDR 201
+ D E CL+ I +P P ++ G +F+++ K D
Sbjct: 225 ---TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTS 278
Query: 202 IAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 258
AG + +DL+ Y + + + ++++G A + YRF+ G L
Sbjct: 279 SLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTML 338
Query: 259 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDT 318
T+ + I+ +H I E +G+ Q + +S I R PS +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDDTNSGMSIPRVNPSVNPS 393
Query: 319 PNP 321
+P
Sbjct: 394 ISP 396
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+ S++ +H D E
Sbjct: 110 ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFV 169
Query: 87 DALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNLKAA-TWKVLNCSGHMRA 141
L P+ ++ ++ F+ RM T N +A ++V+ C
Sbjct: 170 KNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCF----- 224
Query: 142 YKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDR 201
+ D E CL+ I +P P ++ G +F+++ K D
Sbjct: 225 ---TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTS 278
Query: 202 IAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 258
AG + +DL+ Y + + + ++++G A + YRF+ G L
Sbjct: 279 SLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTML 338
Query: 259 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDT 318
T+ + I+ +H I E +G+ Q + +S I R PS +
Sbjct: 339 SAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDDTNSGMSIPRVNPSVNPS 393
Query: 319 PNP 321
+P
Sbjct: 394 ISP 396
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 63.5 bits (153), Expect = 5e-10
Identities = 72/319 (22%), Positives = 134/319 (42%), Gaps = 34/319 (10%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
+ L L+AL+GF V+ EG++ ++SENV+++L +Q EL+ S++ +H D E
Sbjct: 113 DALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFV 172
Query: 87 DALTPQQTLSRRKVEAPTER----CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGH 138
L P+ ++ R F+ RM G ++ + C
Sbjct: 173 KNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF-- 230
Query: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 197
A + P + LQ CL+ + +P P +F +R L K T
Sbjct: 231 -------AVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITS 282
Query: 198 CDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFL 251
D R A G+ +DL+ ++ + ++VS + H +L +G A + YRF
Sbjct: 283 LDTSTMRAAMKPGW--EDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFS 340
Query: 252 ARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PI 308
G + QT++ ++ + + ++ +H L E+ V++ + T Q + PI
Sbjct: 341 LSDGTLVAAQTKSKLIRSQTTNEPQLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPI 398
Query: 309 QRGAPSQKD--TPNPGDSL 325
+P+ + + NPG +
Sbjct: 399 SSNSPAHQALCSGNPGQDM 417
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 63.2 bits (152), Expect = 7e-10
Identities = 75/329 (22%), Positives = 130/329 (39%), Gaps = 24/329 (7%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
+ L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+ S+++ +H D+++
Sbjct: 111 DSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFL 170
Query: 87 DALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 146
L P+ T++ T+ R KS + + + +N S MR
Sbjct: 171 KNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETM 224
Query: 147 QTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD- 200
Q P + E C++ + I G P +F++RH L K D
Sbjct: 225 QCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITRHDLSGKVVNIDTN 283
Query: 201 --RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSKGQAVTGQYRFLARSGG 256
R + G+ +D+I + D + S+ H G A T YRF G
Sbjct: 284 SLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGT 341
Query: 257 YLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQK 316
+ QT++ + V HFL Q E+ G + Q R P+ G S
Sbjct: 342 IVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPVGQGIRPPM-AGCNSSV 398
Query: 317 D--TPNPGDSLDTPGPRILAFLHPPSLSE 343
+ +P L P R P + +
Sbjct: 399 GGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 63.2 bits (152), Expect = 7e-10
Identities = 75/329 (22%), Positives = 130/329 (39%), Gaps = 24/329 (7%)
Query: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
+ L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+ S+++ +H D+++
Sbjct: 111 DSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFL 170
Query: 87 DALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 146
L P+ T++ T+ R KS + + + +N S MR
Sbjct: 171 KNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETM 224
Query: 147 QTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD- 200
Q P + E C++ + I G P +F++RH L K D
Sbjct: 225 QCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITRHDLSGKVVNIDTN 283
Query: 201 --RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSKGQAVTGQYRFLARSGG 256
R + G+ +D+I + D + S+ H G A T YRF G
Sbjct: 284 SLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGT 341
Query: 257 YLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQK 316
+ QT++ + V HFL Q E+ G + Q R P+ G S
Sbjct: 342 IVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPVGQGIRPPM-AGCNSSV 398
Query: 317 D--TPNPGDSLDTPGPRILAFLHPPSLSE 343
+ +P L P R P + +
Sbjct: 399 GGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 51.2 bits (121), Expect = 3e-06
Identities = 89/425 (20%), Positives = 149/425 (35%), Gaps = 106/425 (24%)
Query: 1 MRLTISYLRMH---RLCAAGEWNQVGAGG-EPLDAC------------YLKALEGFVMVL 44
+RL++SYLR+ ++ Q AG P D+C L++L GF +V+
Sbjct: 71 LRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVV 130
Query: 45 TAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQE----ELQDALTPQQTLSRRK- 99
+AEG + Y S + +LG Q +++ +I+D+IH D++ +L A+ P Q + +
Sbjct: 131 SAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPP 190
Query: 100 --------------------VEAPTE------RCFSLRMKSTLTSRGRTLNLKAATWKVL 133
PTE RCF R++ L S L + W++
Sbjct: 191 PLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLR 250
Query: 134 NC----------SGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRG 183
C G ++ + +P+G+ PP L I + P + E +
Sbjct: 251 LCCPEPLMTMQFQGKLKFLFGQKKKAPSGA--MLPPRLSLFCIAAPVLLPSAAEMKMRSA 308
Query: 184 AFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQA 243
++ D T D ++ +L G Y + S+ L+ + Q
Sbjct: 309 LLRAKPRADTAAT-ADAKVKATTSLCESELHGKPNY------SAGRSSRESGVLVLREQT 361
Query: 244 VTGQYRFLARSGGYLWTQTQATVV---SGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
G++ + L + +V GG G + E
Sbjct: 362 DAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREE------------------------ 397
Query: 301 EQHSRRPIQRGAPSQKDTPNPGDSL---------DTPGPRILAFLHPPSLSEAALAADPR 351
EQH G +++TP P L D PR L P +L PR
Sbjct: 398 EQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPR----LQPSKNDPPSLRPMPR 453
Query: 352 RFCSP 356
C P
Sbjct: 454 GSCLP 458
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,660,287
Number of Sequences: 37866
Number of extensions: 1617615
Number of successful extensions: 6465
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 6138
Number of HSP's gapped (non-prelim): 431
length of query: 613
length of database: 18,247,518
effective HSP length: 108
effective length of query: 505
effective length of database: 14,157,990
effective search space: 7149784950
effective search space used: 7149784950
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.