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Search of human proteins with 90421311
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 1345 0.0
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 1331 0.0
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 1241 0.0
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 403 e-112
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 403 e-112
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 403 e-112
gi|21614542 single-minded homolog 1 [Homo sapiens] 228 1e-59
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 228 2e-59
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 228 2e-59
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 216 7e-56
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 208 1e-53
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 205 1e-52
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 119 7e-27
gi|4758010 clock [Homo sapiens] 117 3e-26
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 115 2e-25
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 112 1e-24
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 110 3e-24
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 108 2e-23
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 107 3e-23
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 107 3e-23
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 107 3e-23
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 97 4e-20
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 96 1e-19
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 71 3e-12
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 70 5e-12
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 70 5e-12
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 70 5e-12
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 69 1e-11
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 66 1e-10
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 66 1e-10
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 1345 bits (3481), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT 60
MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT
Sbjct: 1 MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT 60
Query: 61 ISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLS 120
ISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLS
Sbjct: 61 ISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLS 120
Query: 121 QLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLN 180
QLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLN
Sbjct: 121 QLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLN 180
Query: 181 LKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
LKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA
Sbjct: 181 LKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
Query: 241 FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV 300
FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV
Sbjct: 241 FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV 300
Query: 301 TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHS 360
TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHS
Sbjct: 301 TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHS 360
Query: 361 RRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGP 420
RRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGP
Sbjct: 361 RRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGP 420
Query: 421 ILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQ 480
ILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQ
Sbjct: 421 ILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQ 480
Query: 481 DADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLL 540
DADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLL
Sbjct: 481 DADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLL 540
Query: 541 PRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600
PRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH
Sbjct: 541 PRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600
Query: 601 ENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQ 660
ENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQ
Sbjct: 601 ENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQ 660
Query: 661 PRAGSAQAD 669
PRAGSAQAD
Sbjct: 661 PRAGSAQAD 669
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 1331 bits (3445), Expect = 0.0
Identities = 662/664 (99%), Positives = 662/664 (99%)
Query: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Q RSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR
Sbjct: 4 QDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 63
Query: 66 MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI
Sbjct: 64 MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT 185
GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT
Sbjct: 124 GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT 183
Query: 186 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 245
WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH
Sbjct: 184 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 243
Query: 246 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 305
SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR
Sbjct: 244 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 303
Query: 306 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 365
FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ
Sbjct: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 363
Query: 366 RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA 425
RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA
Sbjct: 364 RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA 423
Query: 426 SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL 485
SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL
Sbjct: 424 SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL 483
Query: 486 DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS 545
DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS
Sbjct: 484 DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS 543
Query: 546 DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL 605
DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL
Sbjct: 544 DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL 603
Query: 606 FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS 665
FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS
Sbjct: 604 FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS 663
Query: 666 AQAD 669
AQAD
Sbjct: 664 AQAD 667
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 1241 bits (3210), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 57 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 116
MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
Query: 117 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 176
LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG
Sbjct: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
Query: 177 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 236
RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
Query: 237 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 296
GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
Query: 297 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 356
GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
Query: 357 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 416
EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR
Sbjct: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
Query: 417 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 476
LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL
Sbjct: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
Query: 477 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 536
DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE
Sbjct: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
Query: 537 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 596
PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP
Sbjct: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
Query: 597 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 656
SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG
Sbjct: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
Query: 657 GPFQPRAGSAQAD 669
GPFQPRAGSAQAD
Sbjct: 601 GPFQPRAGSAQAD 613
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 403 bits (1035), Expect = e-112
Identities = 193/351 (54%), Positives = 261/351 (74%), Gaps = 2/351 (0%)
Query: 7 RARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 66
+ + ++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+
Sbjct: 10 KKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV 69
Query: 67 HRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
+L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL G
Sbjct: 70 RKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186
HS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATW
Sbjct: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATW 189
Query: 187 KVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHS 246
KVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHS
Sbjct: 190 KVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHS 247
Query: 247 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRF 306
LDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR
Sbjct: 248 LDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRM 307
Query: 307 LARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 308 LAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 376 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 435
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 436 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 489
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 490 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 549
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 550 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 403 bits (1035), Expect = e-112
Identities = 193/351 (54%), Positives = 261/351 (74%), Gaps = 2/351 (0%)
Query: 7 RARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 66
+ + ++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+
Sbjct: 10 KKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV 69
Query: 67 HRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
+L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL G
Sbjct: 70 RKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186
HS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATW
Sbjct: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATW 189
Query: 187 KVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHS 246
KVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHS
Sbjct: 190 KVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHS 247
Query: 247 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRF 306
LDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR
Sbjct: 248 LDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRM 307
Query: 307 LARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 308 LAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 376 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 435
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 436 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 489
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 490 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 549
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 550 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 403 bits (1035), Expect = e-112
Identities = 235/548 (42%), Positives = 328/548 (59%), Gaps = 50/548 (9%)
Query: 1 MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT 60
M ++ RS++E RKEKSRDAAR RRS+ETEV Y+LAH LP VS+HLDKASIMRL
Sbjct: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
Query: 61 ISYLRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLG 118
IS+LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+SK +G
Sbjct: 61 ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG 120
Query: 119 LSQLELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTLTSRG 176
L+Q+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+T+RG
Sbjct: 121 LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG 180
Query: 177 RTLNLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPP 235
RT+NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP ++ P
Sbjct: 181 RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSHMDIP 238
Query: 236 LGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS 295
L FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS L +
Sbjct: 239 LDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCT 298
Query: 296 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
KGQ V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV S++Q
Sbjct: 299 KGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQ 358
Query: 356 TEQHSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTPGPRI 388
TE + + +GA S+K P PGD++ +
Sbjct: 359 TESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGN 418
Query: 389 LAFLHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQS 442
F + +A L A + R + L + A +TP AT S
Sbjct: 419 QNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSS 478
Query: 443 PLSADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISM 496
+ + P++ +N + +LF DTEA + D + LDLE LAPYI M
Sbjct: 479 CSTPNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAPYIPM 535
Query: 497 D-DDFQLN 503
D +DFQL+
Sbjct: 536 DGEDFQLS 543
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 228 bits (582), Expect = 1e-59
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 15/350 (4%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 75
KEKS++AAR+RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 76 NQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
G G L + L+ L+GF+ V+ +G + Y+SE S HLGLSQ+EL G
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
Query: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAAT 185
+SI+++IHP D +E+ LT Q V E ER F LRMK L R L
Sbjct: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
Query: 186 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 245
+KV++CSG+++ + SP D LV + ++P E L F+ R
Sbjct: 180 YKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
Query: 246 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 305
SLDMK + D R+AE+ GY P DLI + Y ++H D+ + + H LL KGQ T YR
Sbjct: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
Query: 306 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
FLA+ GG++W Q+ AT+V R + IV V+++++ E G+ LSL+Q
Sbjct: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 228 bits (580), Expect = 2e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 73
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 74 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 184
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
Query: 185 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 244
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
Query: 245 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 304
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
Query: 305 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 228 bits (580), Expect = 2e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 73
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 74 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 184
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
Query: 185 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 244
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
Query: 245 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 304
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
Query: 305 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 216 bits (549), Expect = 7e-56
Identities = 140/432 (32%), Positives = 221/432 (51%), Gaps = 71/432 (16%)
Query: 14 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 73
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
Query: 74 E--WNQVGAGGEP------------------------LDACYLKALEGFVMVLTAEGDMA 107
+ WN G P L + L++L+GFV L EG
Sbjct: 81 DPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFL 140
Query: 108 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---------------------- 145
Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
Query: 146 --TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 193
+ Q+ + VE+ + ER F +RMKSTLT RG +++K++ +KV++ +G
Sbjct: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITG 258
Query: 194 HMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 253
+R + S + + LV++ A+P P E + F++R ++D+ Y
Sbjct: 259 RLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIY 313
Query: 254 CDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGY 313
C++RI++ +P D++G Y +IHA D + + S LL+KGQ VT YR++ ++GGY
Sbjct: 314 CENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGY 373
Query: 314 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 373
+W Q+ AT+ + ++I+ V++L+S E + + Q ++ + S +
Sbjct: 374 IWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP----EKTSESSET 429
Query: 374 TPNPGDSLDTPG 385
+ + DS DT G
Sbjct: 430 SDSESDSKDTSG 441
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 208 bits (530), Expect = 1e-53
Identities = 140/451 (31%), Positives = 221/451 (49%), Gaps = 90/451 (19%)
Query: 14 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 73
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
Query: 74 E--WNQVGAGGEP-------------------------------------------LDAC 88
+ WN G P L +
Sbjct: 81 DPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSH 140
Query: 89 YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--- 145
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 141 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
Query: 146 ---------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTS 174
+ Q+ + VE+ + ER F +RMKSTLT
Sbjct: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
Query: 175 RGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEP 234
RG +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 261 RG--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEV 313
Query: 235 PLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLL 294
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL
Sbjct: 314 RIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL 373
Query: 295 SKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLE 354
+KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + +
Sbjct: 374 NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIA 433
Query: 355 QTEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 385
Q ++ + S + + + DS DT G
Sbjct: 434 QLPHLP----EKTSESSETSDSESDSKDTSG 460
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 205 bits (522), Expect = 1e-52
Identities = 141/437 (32%), Positives = 213/437 (48%), Gaps = 82/437 (18%)
Query: 15 RKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE 74
RKEKSR+AARSRR +E ++LA LP +S+ LDKASI+RL+++YLR+ R A G
Sbjct: 46 RKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
Query: 75 --WNQVGAGG--------------------EPLDACYLKALEGFVMVLTAEGDMAYLSEN 112
W AG + L L++L+GFV L EG Y+SE
Sbjct: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
Query: 113 VSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------------------------- 145
VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 146 TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 202
TP+ S KV + ER F +RMKSTLT RG L++KA+ +KV++ +G +RA+
Sbjct: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG- 282
Query: 203 QTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVA 262
LV + +P E PL + R SL + C+ R+++
Sbjct: 283 ----------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
Query: 263 GYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATV 322
P +L+G S Y+++H D+ + +S LL KGQ +TG YR+L R+GG++W Q+ ATV
Sbjct: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
Query: 323 VSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQTEQHSRRPIQRGAPSQ-- 371
G+ P ++ V ++SQ E + ++ E+ P + P++
Sbjct: 387 AGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGK 446
Query: 372 KDTPNPGDSLDTPGPRI 388
+ P ++ T G RI
Sbjct: 447 QAAPAENEAPQTQGKRI 463
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 119 bits (299), Expect = 7e-27
Identities = 109/393 (27%), Positives = 179/393 (45%), Gaps = 50/393 (12%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 75
+E + RR + ++ +L+ +P ++ LDK +++R+ + +LR + G
Sbjct: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLK----GLT 164
Query: 76 NQ-VGAGGEP-------LDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIG 126
N VG+ P L LK EGF+ V+ E G + ++S++VSK L Q L G
Sbjct: 165 NSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTG 224
Query: 127 HSIFDFIHPCD---------------QEELQDALTPQQTLS-----RRKVEAPTERCFSL 166
S+FDF+HP D +E+L DA T Q S R +V + + R F
Sbjct: 225 QSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFC 284
Query: 167 RMKSTLTS----RGRTLNLKAATWK---VLNCSGHMRAYKPP--AQTSPAGSPDSEPPLQ 217
R+KS S G N K + ++C+G++R++ P S
Sbjct: 285 RIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFT 344
Query: 218 CLVLICEAIPH---PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSA 274
CLV I P+ S E + F++R +++ KF Y D R + GY P +L+G S
Sbjct: 345 CLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSC 404
Query: 275 YEYIHALD-SDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSES 333
YEY H D ++ K L SK + +T Y+F A+ G ++ ++Q + + E
Sbjct: 405 YEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEY 464
Query: 334 IVCVHFLISQVEETG----VVLSLEQTEQHSRR 362
IV V+ L+ E G + S + +E+ SR+
Sbjct: 465 IVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQ 497
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 117 bits (293), Expect = 3e-26
Identities = 96/391 (24%), Positives = 172/391 (43%), Gaps = 54/391 (13%)
Query: 4 GLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 63
GL + ++ + + RR Q ++ +L LP G + +DK+++++ +I +
Sbjct: 24 GLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDF 80
Query: 64 LRMHRLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSK 115
LR H+ A +W E L+AL+GF + + +G + Y+SE+V+
Sbjct: 81 LRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTS 140
Query: 116 HLGLSQLELIGHSIFDFIHPCDQEEL----------QDALTPQQTLSRRKVEAPTERCFS 165
L +L+ SIF+FI + E+ D+LTP+ S+ ++E F
Sbjct: 141 LLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLE------FC 194
Query: 166 LRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAG---------SPDSEPPL 216
M RG + +T++ + G+ ++ + ++ G P E +
Sbjct: 195 CHML-----RGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRV 249
Query: 217 QCLVLICEAIPH----PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272
+ + A P ++E P F SRHSL+ KF + D R + GY P +++G
Sbjct: 250 CFVATVRLATPQFIKEMCTVEEP--NEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGT 307
Query: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSE 332
S Y+Y H D + ++K L+ G+ + YRFL + ++W QT + + E
Sbjct: 308 SGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPE 367
Query: 333 SIVCVHFLISQVE-------ETGVVLSLEQT 356
IVC H ++S E E G+ SL +T
Sbjct: 368 FIVCTHTVVSYAEVRAERRRELGIEESLPET 398
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 115 bits (287), Expect = 2e-25
Identities = 101/423 (23%), Positives = 184/423 (43%), Gaps = 73/423 (17%)
Query: 12 TELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA 71
++ +E + R RR++ T+ + +L+ +P ++ DK +I+R+ +S+++ R
Sbjct: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR--- 117
Query: 72 AGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTAE-GDMAYLSENVSKH 116
G G + D Y L+A +GF+ V+ AE G + Y+S++V+
Sbjct: 118 -------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPV 170
Query: 117 LGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT--------------- 160
L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 171 LNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMC 230
Query: 161 ---ERCFSLRMK--------------STLTSRGRT----LNLKAATWKVLNCSGHMRAYK 199
R F RM+ +T+ R R + A + V++C+G+++A+
Sbjct: 231 MGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWP 290
Query: 200 PPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYC 254
P T P D + CLV I + P + FLSRH+ D T+
Sbjct: 291 PAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFV 350
Query: 255 DDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGY 313
D R V GY P DL+G E+ H D + +S ++ KGQ ++ YRF ++ +
Sbjct: 351 DPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREW 410
Query: 314 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 373
+ +T + + E I+C + + Q+++ L E H R + SQ
Sbjct: 411 MLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EVHQRDGLSSYDLSQVP 465
Query: 374 TPN 376
PN
Sbjct: 466 VPN 468
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 112 bits (279), Expect = 1e-24
Identities = 88/381 (23%), Positives = 173/381 (45%), Gaps = 48/381 (12%)
Query: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Q + L +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++
Sbjct: 81 QSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
Query: 66 MHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLS 120
R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
Query: 121 QLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------E 161
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Query: 162 RCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQ 203
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
Query: 204 TSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRI 258
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D R
Sbjct: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
Query: 259 AEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQ 317
GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +
Sbjct: 381 VATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 440
Query: 318 TQATVVSGGRGPQSESIVCVH 338
T + + E I+C +
Sbjct: 441 TSSFTFQNPYSDEIEYIICTN 461
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 110 bits (276), Expect = 3e-24
Identities = 87/381 (22%), Positives = 172/381 (45%), Gaps = 48/381 (12%)
Query: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Q + +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++
Sbjct: 66 QMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 125
Query: 66 MHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLS 120
R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 126 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
Query: 121 QLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------E 161
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Query: 162 RCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQ 203
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
Query: 204 TSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRI 258
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D R
Sbjct: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
Query: 259 AEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQ 317
GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +
Sbjct: 366 VATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMR 425
Query: 318 TQATVVSGGRGPQSESIVCVH 338
T + + E I+C +
Sbjct: 426 TSSFTFQNPYSDEIEYIICTN 446
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 108 bits (270), Expect = 2e-23
Identities = 115/474 (24%), Positives = 200/474 (42%), Gaps = 54/474 (11%)
Query: 13 ELRKEKSRDAARS-----RRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH 67
E K++++ A+R+ RR Q ++ +L+ LP G + +DK +++ I +L+ H
Sbjct: 3 EDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKH 59
Query: 68 RLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGL 119
+A +W E L+AL+GF++ +T +G + Y+S++++ LG
Sbjct: 60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGH 119
Query: 120 SQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTL 179
+++ ++ +F+ + E+ L+ ++ + L L RG
Sbjct: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLN 178
Query: 180 NLKAATWKVLNCSGHMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAI 226
+ T++ + G+ R+Y S G + S P PL C + + +
Sbjct: 179 PKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFL 238
Query: 227 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 286
++ PL F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +
Sbjct: 239 KEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELL 296
Query: 287 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE- 345
++ L+ G+ + YRFL + ++W QT + + E IVC H ++S +
Sbjct: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADV 356
Query: 346 --ETGVVLSLEQTEQ---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEA 400
E L+LE HS +G S + ++LD G L H PS S
Sbjct: 357 RVERRQELALEDPPSEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSR 413
Query: 401 ALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 454
+ S P + A STP P SA LP ELPV
Sbjct: 414 SSHKSSHTAMSE-------PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 107 bits (268), Expect = 3e-23
Identities = 86/343 (25%), Positives = 156/343 (45%), Gaps = 47/343 (13%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA---- 71
+E + RR + + +LA +P +S LDK +++R+ + +++ R
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
Query: 72 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 130
+ + L L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+F
Sbjct: 91 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 150
Query: 131 DFIHPCDQEELQDALTPQQTLSR-RKVEAPT-------------------ERCFSLRMKS 170
D++HP D ++++ L+ T R R ++A T R F RMK
Sbjct: 151 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 210
Query: 171 TLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----L 216
S T + K ++ ++ +G+++++ P T D+EP L
Sbjct: 211 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNL 267
Query: 217 QCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272
CLV I +P P + E + ++SRH++D KF + D R + Y P +L+G
Sbjct: 268 SCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGT 327
Query: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 314
S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 328 SCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 370
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 107 bits (268), Expect = 3e-23
Identities = 86/343 (25%), Positives = 156/343 (45%), Gaps = 47/343 (13%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA---- 71
+E + RR + + +LA +P +S LDK +++R+ + +++ R
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 72 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 130
+ + L L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+F
Sbjct: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
Query: 131 DFIHPCDQEELQDALTPQQTLSR-RKVEAPT-------------------ERCFSLRMKS 170
D++HP D ++++ L+ T R R ++A T R F RMK
Sbjct: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
Query: 171 TLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----L 216
S T + K ++ ++ +G+++++ P T D+EP L
Sbjct: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNL 310
Query: 217 QCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272
CLV I +P P + E + ++SRH++D KF + D R + Y P +L+G
Sbjct: 311 SCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGT 370
Query: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 314
S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 371 SCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 107 bits (268), Expect = 3e-23
Identities = 86/343 (25%), Positives = 156/343 (45%), Gaps = 47/343 (13%)
Query: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA---- 71
+E + RR + + +LA +P +S LDK +++R+ + +++ R
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 72 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 130
+ + L L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+F
Sbjct: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
Query: 131 DFIHPCDQEELQDALTPQQTLSR-RKVEAPT-------------------ERCFSLRMKS 170
D++HP D ++++ L+ T R R ++A T R F RMK
Sbjct: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
Query: 171 TLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----L 216
S T + K ++ ++ +G+++++ P T D+EP L
Sbjct: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNL 310
Query: 217 QCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272
CLV I +P P + E + ++SRH++D KF + D R + Y P +L+G
Sbjct: 311 SCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGT 370
Query: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 314
S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 371 SCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 97.4 bits (241), Expect = 4e-20
Identities = 93/350 (26%), Positives = 147/350 (42%), Gaps = 55/350 (15%)
Query: 18 KSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQ 77
KS + R R TE L +LA LPF + V LDK S++RL++SYLR +
Sbjct: 32 KSNPSKRHRDRLNTE-LDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
Query: 78 VGAGGEPLDAC----------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 121
D C L+AL GFV+V+T + + Y S + +LG Q
Sbjct: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
Query: 122 LELIGHSIFDFIHPCDQEELQD----ALTPQQ-TLSRRKVEAPT---------------- 160
++I S+++ IH D+ E Q AL P Q T S + +E T
Sbjct: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
Query: 161 ------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEP 214
ERCF R++ L + ++ + +N G ++ + GS P
Sbjct: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILP 260
Query: 215 PLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCS 273
P L I + P LE F ++H LD CD + V GY+ +L S
Sbjct: 261 PQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGS 320
Query: 274 AYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVV 323
Y++IHA D ++S ++ G++ +R L ++ + W Q+ A ++
Sbjct: 321 GYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLL 370
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 95.9 bits (237), Expect = 1e-19
Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)
Query: 19 SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 78
++ A+++RR Q + L LP A L IM L Y R A G +
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
Query: 79 GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 132
L A L+ AL GF++V TAEG + YLSE+VS+HLG S ++L+ G SI+D
Sbjct: 63 AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
Query: 133 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 192
I P D ++ LT L T+R F R ++ ++L ++A K++
Sbjct: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
Query: 193 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 252
G A+ P A AG+P L P PG L F SRH+ D+
Sbjct: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
Query: 253 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 310
+ + G+ +L+ S Y +H D S + LL++ + + R A++
Sbjct: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
Query: 311 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 369
GG+ W G GP I ++ IS +E + L + + + G P
Sbjct: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
Query: 370 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 416
SQ++ + NP + PR +F P LS + + + PR D
Sbjct: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
Query: 417 LLGPILDGASVAATPSTPLATRHPQSP 443
L P S+ A S L P +P
Sbjct: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/465 (22%), Positives = 169/465 (36%), Gaps = 107/465 (23%)
Query: 17 EKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH---RLCAAG 73
EKS + R R E L LA LPF + + LDK S++RL++SYLR+ ++
Sbjct: 32 EKSNPSKRHRDRLNAE-LDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ 90
Query: 74 EWNQVGAGG-EPLDAC------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLS 120
Q AG P D+C L++L GF +V++AEG + Y S + +LG
Sbjct: 91 SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFH 150
Query: 121 QLELIGHSIFDFIHPCDQE----ELQDALTPQQTLSRRK--------------------- 155
Q +++ +I+D+IH D++ +L A+ P Q + +
Sbjct: 151 QTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWG 210
Query: 156 VEAPTE------RCFSLRMKSTLTSRGRTLNLKAATWKVLNC----------SGHMRAYK 199
PTE RCF R++ L S L + W++ C G ++
Sbjct: 211 TGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLF 270
Query: 200 PPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 259
+ +P+G+ PP L I + P + E + ++ D T D ++
Sbjct: 271 GQKKKAPSGA--MLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAAT-ADAKVK 327
Query: 260 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQ 319
+L G Y + S+ L+ + Q G++ + L +
Sbjct: 328 ATTSLCESELHGKPNY------SAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGG 381
Query: 320 ATVV---SGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPN 376
+V GG G + E EQH G +++TP
Sbjct: 382 PDLVLDPKGGSGDREE------------------------EQHRMLSRASGVTGRRETPG 417
Query: 377 PGDSL---------DTPGPRILAFLHPPSLSEAALAADPRRFCSP 412
P L D PR L P +L PR C P
Sbjct: 418 PTKPLPWTAGKHSEDGARPR----LQPSKNDPPSLRPMPRGSCLP 458
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 24 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 72
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 73 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 181
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 182 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 241 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 297
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 298 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 358 QHSRRPIQRGAPSQKDTPNP 377
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 24 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 72
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 73 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 181
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 182 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 241 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 297
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 298 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 358 QHSRRPIQRGAPSQKDTPNP 377
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 24 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 72
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 73 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 126 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 181
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 182 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 241 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 297
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 298 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 358 QHSRRPIQRGAPSQKDTPNP 377
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 69.3 bits (168), Expect = 1e-11
Identities = 96/421 (22%), Positives = 173/421 (41%), Gaps = 62/421 (14%)
Query: 8 ARSTTELRKE--------KSRDAARSRRSQETEVLYQLAHTLPFAR-----GVSAHLDKA 54
+R+ T RKE R+ + R QE + + +LA + FA + DK
Sbjct: 12 SRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELI-FANFNDIDNFNFKPDKC 70
Query: 55 SIMRLTISYLRM---HRLCAAGEWNQV--------GAGGEPLDAC---YLKALEGFVMVL 100
+I++ T+ +R AA ++V G G DA L+AL+GF V+
Sbjct: 71 AILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVV 130
Query: 101 TAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPT 160
EG++ ++SENV+++L +Q EL+ S++ +H D E L P+ ++
Sbjct: 131 NLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEP 190
Query: 161 ER----CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDS 212
R F+ RM G ++ + C A + P +
Sbjct: 191 PRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF---------AVSQPKSIKEE 241
Query: 213 EPPLQ-CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD---RIAEVAGYSPDD 268
LQ CL+ + +P P +F +R L K T D R A G+ +D
Sbjct: 242 GEDLQSCLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITSLDTSTMRAAMKPGW--ED 298
Query: 269 LIGCSAYEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSG 325
L+ ++ + ++VS + H +L +G A + YRF G + QT++ ++
Sbjct: 299 LVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRS 358
Query: 326 GRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PIQRGAPSQKD--TPNPGDS 380
+ + ++ +H L E+ V++ + T Q + PI +P+ + + NPG
Sbjct: 359 QTTNEPQLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQD 416
Query: 381 L 381
+
Sbjct: 417 M 417
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 65.9 bits (159), Expect = 1e-10
Identities = 89/405 (21%), Positives = 158/405 (39%), Gaps = 41/405 (10%)
Query: 24 RSRRSQETEVLYQLAH----TLPFARGVSAHLDKASIMRLTISYLRMHRL---------- 69
+ RR QE++ + +LA L + DK +I++ T+ +R +
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDD 94
Query: 70 CAAGEWNQVGAG---GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
+ + G G + L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+
Sbjct: 95 VQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVN 154
Query: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186
S+++ +H D+++ L P+ T++ T+ R KS + +
Sbjct: 155 TSVYNILHEEDRKDFLKNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDIL 208
Query: 187 KVLNCSGHMRAYKPPAQTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAF 241
+ +N S MR Q P + E C++ + I G P +F
Sbjct: 209 EDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESF 267
Query: 242 LSRHSLDMKFTYCDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSK 296
++RH L K D R + G+ +D+I + D + S+ H
Sbjct: 268 ITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLN 325
Query: 297 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 356
G A T YRF G + QT++ + V HFL Q E+ G +
Sbjct: 326 GHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPV 383
Query: 357 EQHSRRPIQRGAPSQKD--TPNPGDSLDTPGPRILAFLHPPSLSE 399
Q R P+ G S + +P L P R P + +
Sbjct: 384 GQGIRPPM-AGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 65.9 bits (159), Expect = 1e-10
Identities = 89/405 (21%), Positives = 158/405 (39%), Gaps = 41/405 (10%)
Query: 24 RSRRSQETEVLYQLAH----TLPFARGVSAHLDKASIMRLTISYLRMHRL---------- 69
+ RR QE++ + +LA L + DK +I++ T+ +R +
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDD 94
Query: 70 CAAGEWNQVGAG---GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
+ + G G + L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+
Sbjct: 95 VQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVN 154
Query: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186
S+++ +H D+++ L P+ T++ T+ R KS + +
Sbjct: 155 TSVYNILHEEDRKDFLKNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDIL 208
Query: 187 KVLNCSGHMRAYKPPAQTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAF 241
+ +N S MR Q P + E C++ + I G P +F
Sbjct: 209 EDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESF 267
Query: 242 LSRHSLDMKFTYCDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSK 296
++RH L K D R + G+ +D+I + D + S+ H
Sbjct: 268 ITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLN 325
Query: 297 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 356
G A T YRF G + QT++ + V HFL Q E+ G +
Sbjct: 326 GHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPV 383
Query: 357 EQHSRRPIQRGAPSQKD--TPNPGDSLDTPGPRILAFLHPPSLSE 399
Q R P+ G S + +P L P R P + +
Sbjct: 384 GQGIRPPM-AGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,282,071
Number of Sequences: 37866
Number of extensions: 1694727
Number of successful extensions: 6814
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 6465
Number of HSP's gapped (non-prelim): 447
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.