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Search of human proteins with 89886480
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89886480 zinedin isoform 2 [Homo sapiens]
(760 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89886480 zinedin isoform 2 [Homo sapiens] 1540 0.0
gi|89886477 zinedin isoform 1 [Homo sapiens] 1519 0.0
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 753 0.0
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 752 0.0
gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 707 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 99 1e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 99 1e-20
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 9e-20
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 96 2e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 89 2e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 87 8e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 87 8e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 86 1e-16
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 84 6e-16
gi|26665869 WD repeat domain 51B [Homo sapiens] 80 9e-15
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 1e-14
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 79 2e-14
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 79 2e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 2e-14
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 78 3e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 77 8e-14
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 74 4e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 74 5e-13
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 73 9e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 73 9e-13
gi|19913369 transducin beta-like 3 [Homo sapiens] 72 2e-12
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 71 3e-12
gi|13376840 WD repeat domain 61 [Homo sapiens] 71 3e-12
gi|113865883 WD repeat domain 38 [Homo sapiens] 71 4e-12
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 1540 bits (3987), Expect = 0.0
Identities = 760/760 (100%), Positives = 760/760 (100%)
Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
Query: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420
RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420
Query: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480
SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA
Sbjct: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480
Query: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540
KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP
Sbjct: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540
Query: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600
SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP
Sbjct: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600
Query: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI
Sbjct: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
Query: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC
Sbjct: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
Query: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 1519 bits (3933), Expect = 0.0
Identities = 753/760 (99%), Positives = 753/760 (99%), Gaps = 7/760 (0%)
Query: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP
Sbjct: 1 MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGP 60
Query: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM
Sbjct: 61 EPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKM 120
Query: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ
Sbjct: 121 LEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQ 180
Query: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI
Sbjct: 181 YLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV
Sbjct: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALV 300
Query: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL
Sbjct: 301 PEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADL 360
Query: 361 RDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDNDL 420
RDVDGLPPKVTGPPPGTPQPRPHE DVFIMDTIGGGEVSLGDLADLTVTNDNDL
Sbjct: 361 RDVDGLPPKVTGPPPGTPQPRPHE-------DVFIMDTIGGGEVSLGDLADLTVTNDNDL 413
Query: 421 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 480
SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA
Sbjct: 414 SCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTA 473
Query: 481 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 540
KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP
Sbjct: 474 KKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDP 533
Query: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600
SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP
Sbjct: 534 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 593
Query: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI
Sbjct: 594 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
Query: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC
Sbjct: 654 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 713
Query: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV
Sbjct: 714 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 753
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 753 bits (1945), Expect = 0.0
Identities = 429/825 (52%), Positives = 532/825 (64%), Gaps = 115/825 (13%)
Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELE------- 347
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+ + +
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWDKDDLSPTAE 339
Query: 348 ----------------------------SRRVKLQGILADLRDVDGLPPKVTG----PPP 375
+ R KL ++ADL D D LP +G
Sbjct: 340 VWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGD-DELPHIPSGIINQSRS 398
Query: 376 GTPQPRPHEG-----------------SFGFSSDVFIMDTIGGGEVSLGDLADLTVTNDN 418
+ + HEG SF SD ++ +G LGDLADLTVTND
Sbjct: 399 ASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLG-----LGDLADLTVTNDA 453
Query: 419 DLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
D S DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNLQK V
Sbjct: 454 DYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTV 513
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 538
AKK+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DPYD Y
Sbjct: 514 PAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTY 573
Query: 539 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 598
+P+VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+ +HG
Sbjct: 574 EPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGDKKHG 632
Query: 599 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVVSHPN 655
+PTSV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VVSHP
Sbjct: 633 IPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPT 692
Query: 656 QPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL 715
P+TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+RLW+L
Sbjct: 693 LPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL 752
Query: 716 DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
D+KTCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 753 DSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 797
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 752 bits (1941), Expect = 0.0
Identities = 418/769 (54%), Positives = 514/769 (66%), Gaps = 87/769 (11%)
Query: 20 LGSGAGPGPTGAAPVSAPAPGPG------PAGKGGGGGGSP------GPTAGPE-----P 62
L G G GP AAP GPG P G G GGG P GP AGPE
Sbjct: 4 LAGGGGGGPGMAAP-PRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQ 62
Query: 63 LSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLE 122
++PGILH+IQHEWARFE E+A WE ERAELQA++AFLQGERKGQENLK DLVRRIKMLE
Sbjct: 63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLE 122
Query: 123 YALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTL-ENSPLVWKEGRQLLRQY 181
YALKQERAKYHKLK+GT+LNQG+ K E E+ T +NS L WK+GRQLLRQY
Sbjct: 123 YALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQY 182
Query: 182 LEEVGYTDTILDMRSKRVRSLLGRS-LELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQI 240
L+EVGYTDTILD+RS+RVRSLLG S E NG+VE L+GGES KQ
Sbjct: 183 LQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQI-------LNGGES--PKQK 233
Query: 241 EEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDEL------DSVQHKKQRVKL 294
++IKR++ G VL FL+N +D D DE++++ +H+ + K+
Sbjct: 234 GQEIKRSS----------GDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKI 283
Query: 295 PSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQ 354
++ L ++ D+ D+E+A+ EFDFL + EDGEGA + R + DG+
Sbjct: 284 GNEGLAADLTDDP---DTEEALKEFDFLVTAEDGEGAGEARS-SGDGTEWA--------- 330
Query: 355 GILADLRDVDGLPPKVTGPPPGTPQPRPHEGSFGFSSDVFIMDTIGGGEVSLGDLADLTV 414
+T P G SF SD ++ +G LGDLADLTV
Sbjct: 331 -------------EPITFPSGGGK-------SFIMGSDDVLLSVLG-----LGDLADLTV 365
Query: 415 TNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNL 474
TND D S DL +KDAF+KTWNPK+TLRSH+DG+R+LAFH + L+TASED TLKLWNL
Sbjct: 366 TNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 425
Query: 475 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 534
QK V AKK+A+LDVEPI+ FRAH GPVL++A+ SN E C+SGG DA I W +P S+DP
Sbjct: 426 QKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDP 485
Query: 535 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 594
YD Y+P+VL+ L GH DAVWGLA+S +L SCSADGTVR+W+P P C+CT+
Sbjct: 486 YDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLP-CICTYNGD 544
Query: 595 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG---PTQINQVV 651
+HG+PTSV F +PAH+V SF +G V+YD+E +L+ L S+ SG IN+VV
Sbjct: 545 KKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVV 604
Query: 652 SHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLR 711
SHP P+TITAH+DR I+F DN+TGK +HSMVAHLDAVT LAVDPNG +LMSGSHDCS+R
Sbjct: 605 SHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIR 664
Query: 712 LWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760
LW+LD+KTCVQEITAHRKK +E+I+ VA H SKA IASAGADALAKVFV
Sbjct: 665 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713
>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
Length = 780
Score = 707 bits (1826), Expect = 0.0
Identities = 397/795 (49%), Positives = 502/795 (63%), Gaps = 77/795 (9%)
Query: 24 AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80
AGPG + P + A G GP + G G+ A SLPGILHF+QHEWARFE
Sbjct: 5 AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64
Query: 81 AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140
E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+
Sbjct: 65 VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124
Query: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200
LNQG+ K + E +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR
Sbjct: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184
Query: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260
+LLG S ++ + + +V E ++K A + S
Sbjct: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229
Query: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320
VL FL++ + SDED++ D +K + + + D E+ D+++A+ EFD
Sbjct: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289
Query: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349
FL + E+G+ + R DG+ E E +
Sbjct: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346
Query: 350 ----RVKLQGILADLRDVDGLP---PKVTGPP-PGTPQPRPHEGSFG----------FSS 391
R KLQ +LA+LRDVD LP P V P P + + HE + S
Sbjct: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406
Query: 392 DVFIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 448
FIM D E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI
Sbjct: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466
Query: 449 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 508
R+LAFH + L+TASED TLK+WNLQK AKK+ +LDVEPI+ FRAH+GPVL V M S
Sbjct: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526
Query: 509 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 568
N E CYSGG D I W + ++DPYD YDPSVL L GH DAVWGLA+S QRL S
Sbjct: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586
Query: 569 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 628
CSADGT+R+W+ + +PA L F E G+P SV S++P+H+VASF G T +++ME
Sbjct: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645
Query: 629 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 685
+LTLES ++ QIN+V+SHP P++ITAH+DR I+F DN TGK +HSMVAH
Sbjct: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705
Query: 686 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 745
L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK
Sbjct: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765
Query: 746 LIASAGADALAKVFV 760
IASAGADALAKVFV
Sbjct: 766 YIASAGADALAKVFV 780
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)
Query: 432 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 491
K + KFTL H + S+ F + L ++S D +K+W A D +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80
Query: 492 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 551
H+ + VA S+S S D + W + L+GH
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129
Query: 552 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 611
+ V+ F+P S + S S D +VRIWD + CL T P H P S + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184
Query: 612 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 671
IV+S G ++D G L TL + ++ V PN + A D ++
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241
Query: 672 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 728
D GK + + H + C+ + G +++SGS D + +W+L K VQ++
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297
Query: 729 KKHEEAIHAVACHPSKALIASAGAD 753
+ H + + + ACHP++ +IASA +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 647 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 706
I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 707 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
D S+R+W + C++ + A H + + AV + +LI S+ D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/325 (25%), Positives = 137/325 (42%), Gaps = 37/325 (11%)
Query: 432 KKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI 491
K + KFTL H + S+ F + L ++S D +K+W A D +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFE 80
Query: 492 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 551
H+ + VA S+S S D + W + L+GH
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-----------GKCLKTLKGHS 129
Query: 552 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 611
+ V+ F+P S + S S D +VRIWD + CL T P H P S + + +
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPA---HSDPVSAVHFNRDGS 184
Query: 612 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 671
IV+S G ++D G L TL + ++ V PN + A D ++
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241
Query: 672 DNRTGKPVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 728
D GK + + H + C+ + G +++SGS D + +W+L K VQ++
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---- 297
Query: 729 KKHEEAIHAVACHPSKALIASAGAD 753
+ H + + + ACHP++ +IASA +
Sbjct: 298 QGHTDVVISTACHPTENIIASAALE 322
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 647 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 706
I+ V + L ++A DD+ ++ D +GK + ++ H + V C +P ++SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 707 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
D S+R+W + C++ + A H + + AV + +LI S+ D L +++
Sbjct: 150 DESVRIWDVKTGKCLKTLPA----HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 96.3 bits (238), Expect = 9e-20
Identities = 49/82 (59%), Positives = 59/82 (71%), Gaps = 9/82 (10%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKKADVSEQVS 155
KLK+G +LNQG+ K + + S
Sbjct: 67 KLKYGRELNQGDMKPPIYDSDS 88
>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 95.5 bits (236), Expect = 2e-19
Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKK 147
KLK+G +LNQG+ K
Sbjct: 67 KLKYGRELNQGDMK 80
>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
Length = 127
Score = 95.5 bits (236), Expect = 2e-19
Identities = 48/74 (64%), Positives = 56/74 (75%), Gaps = 9/74 (12%)
Query: 83 KARWEAERAELQ---------AQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYH 133
K+RWE + Q AQ+AFLQGERK QENLK DLVR+IKMLEYALKQ+RAKYH
Sbjct: 7 KSRWETGEVQAQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYH 66
Query: 134 KLKFGTDLNQGEKK 147
KLK+G +LNQG+ K
Sbjct: 67 KLKYGRELNQGDMK 80
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/319 (24%), Positives = 131/319 (41%), Gaps = 37/319 (11%)
Query: 438 KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 497
K TL H + + S+ F + L ++S D + +W A D + H
Sbjct: 34 KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG-----------AYDGKYEKTLYGH 82
Query: 498 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 557
+ VA S+S S D + W + L+GH + V+
Sbjct: 83 NLEISDVAWSSDSSRLVSASDDKTLKLWDVRS-----------GKCLKTLKGHSNYVFCC 131
Query: 558 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 617
F+P S + S S D TV+IW+ + CL T S H P S + + IV+
Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGK--CL---KTLSAHSDPVSAVHFNCSGSLIVSGS 186
Query: 618 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 677
G ++D G L TL + ++ V PN +TA D ++ D G+
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNP---PVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Query: 678 PVHSMVAHLDAVTCLAVD---PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEA 734
+ + H + C+ + G +++SGS D + +W+L K VQ++ H +
Sbjct: 244 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT----DV 299
Query: 735 IHAVACHPSKALIASAGAD 753
+ + ACHP++ LIASA +
Sbjct: 300 VISAACHPTENLIASAALE 318
Score = 67.0 bits (162), Expect = 6e-11
Identities = 47/182 (25%), Positives = 85/182 (46%), Gaps = 9/182 (4%)
Query: 543 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 602
L L GH +AV + FSP + LAS SAD + IW T H + S
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-----KTLYGHNLEIS 87
Query: 603 VAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA 662
S++ + +V++ L+D+ G L TL+ + + +P L I+
Sbjct: 88 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN----YVFCCNFNPPSNLIISG 143
Query: 663 HDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQ 722
D ++ + +TGK + ++ AH D V+ + + +G+ ++SGS+D R+W + C++
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 723 EI 724
+
Sbjct: 204 TL 205
Score = 56.2 bits (134), Expect = 1e-07
Identities = 29/114 (25%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 646 QINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGS 705
+I+ V + ++A DD+ ++ D R+GK + ++ H + V C +P ++SGS
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 706 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
D ++++W + C++ ++A H + + AV + S +LI S D L +++
Sbjct: 145 FDETVKIWEVKTGKCLKTLSA----HSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 86.7 bits (213), Expect = 8e-17
Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)
Query: 494 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 553
F+ HR V V N++ SG D+C+ W + P ++ GH DA
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63
Query: 554 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 613
V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + +
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119
Query: 614 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 672
AS TV ++ L +L S + P+ L ++A DD+ ++ D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 673 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 732
+ + VHS H VT + P+G + + D ++++W + +Q H + H
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229
Query: 733 EAIHAVACHPSKALIASAGADALAKV 758
A++ ++ HPS + +A +D+ K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)
Query: 425 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 477
S S D+ W+ K + H D + + F S L + S D T+++W N++
Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95
Query: 478 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 537
T FRAH V +V S+ + + D + W
Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132
Query: 538 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 597
L H + V FSP + + S S D TV++WD SS C
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187
Query: 598 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 657
G T V F + I A+ ++D+ L + ++ +N + HP+
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242
Query: 658 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
ITA D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 421 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 475
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 476 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 86.7 bits (213), Expect = 8e-17
Identities = 70/266 (26%), Positives = 118/266 (44%), Gaps = 26/266 (9%)
Query: 494 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 553
F+ HR V V N++ SG D+C+ W + P ++ GH DA
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFTGHKDA 63
Query: 554 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 613
V + FSP+ LAS S D TVRIW P+ + + TA+ SV F S + +
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVR----SVHFCSDGQSFV 119
Query: 614 VASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD 672
AS TV ++ L +L S + P+ L ++A DD+ ++ D
Sbjct: 120 TAS--DDKTVKVWATHRQKFLFSL----SQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 673 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 732
+ + VHS H VT + P+G + + D ++++W + +Q H + H
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHS 229
Query: 733 EAIHAVACHPSKALIASAGADALAKV 758
A++ ++ HPS + +A +D+ K+
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/296 (22%), Positives = 110/296 (37%), Gaps = 40/296 (13%)
Query: 425 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKA 477
S S D+ W+ K + H D + + F S L + S D T+++W N++
Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE 95
Query: 478 VTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDG 537
T FRAH V +V S+ + + D + W
Sbjct: 96 STV-------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT---------- 132
Query: 538 YDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH 597
L H + V FSP + + S S D TV++WD SS C
Sbjct: 133 -HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHG 187
Query: 598 GVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP 657
G T V F + I A+ ++D+ L + ++ +N + HP+
Sbjct: 188 GFVTYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGN 242
Query: 658 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
ITA D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 421 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 475
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 476 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 260 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 86.3 bits (212), Expect = 1e-16
Identities = 80/341 (23%), Positives = 139/341 (40%), Gaps = 62/341 (18%)
Query: 424 LSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
+S S+DA K W+ + TL+ H D ++ ++F HS L + S D T+KLW+ Q
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--- 180
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 538
E I H V +VA+ N ++ S D I W++ GY
Sbjct: 181 --------GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV-------QTGY 225
Query: 539 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 598
+ GH + V + + +ASCS D TVR+W ++ C
Sbjct: 226 CVKTFT----GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE----CKAELREHEH 277
Query: 599 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 658
V +++ + E ++ S +G E++ S P P
Sbjct: 278 VVECISW-APESSYSSISEATGS---------------ETKKSGKP-----------GPF 310
Query: 659 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 718
++ D+ I+ D TG + ++V H + V + G F++S + D +LR+W NK
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 719 TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
C++ + A HE + ++ H + + + D KV+
Sbjct: 371 RCMKTLNA----HEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 74.7 bits (182), Expect = 3e-13
Identities = 70/292 (23%), Positives = 117/292 (40%), Gaps = 52/292 (17%)
Query: 492 HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHG 551
+A HR PV V S DA I W Y+ L+GH
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-----------YETGDFERTLKGHT 150
Query: 552 DAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP- 610
D+V ++F + + LASCSAD T+++WD C+ T HG +V+ + P
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFE--CIRTM-----HGHDHNVSSVAIMPN 203
Query: 611 -AHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITA--HDDRG 667
HIV++ R +++++ G + T +G + ++V PNQ T+ A +D+
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTF-----TGHREWVRMV-RPNQDGTLIASCSNDQT 257
Query: 668 IRFLDNRTGKPVHSMVAHLDAVTCLAVDPN--------------------GAFLMSGSHD 707
+R T + + H V C++ P G FL+SGS D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 708 CSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
++++W + C+ + H+ + V H I S D +V+
Sbjct: 318 KTIKMWDVSTGMCLMTLVG----HDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 31.6 bits (70), Expect = 2.9
Identities = 26/120 (21%), Positives = 42/120 (35%), Gaps = 22/120 (18%)
Query: 460 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 519
LL+ S D T+K+W++ + + H V V S ++ S D
Sbjct: 311 LLSGSRDKTIKMWDVSTGMC-----------LMTLVGHDNWVRGVLFHSGGKFILSCADD 359
Query: 520 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579
+ W Y L H V L F T+ + + S D TV++W+
Sbjct: 360 KTLRVWD-----------YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 83.6 bits (205), Expect = 6e-16
Identities = 90/339 (26%), Positives = 138/339 (40%), Gaps = 47/339 (13%)
Query: 432 KKTWNPKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALD 487
K W+P + L H +R +A +T S D T+K+W+L + K +L
Sbjct: 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL- 242
Query: 488 VEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVL 547
H V V + + S Y +S G D + W DL + V+ H
Sbjct: 243 -------TGHISTVRGVIVSTRSPYLFSCGEDKQVKCW---DLEYN-------KVIRH-Y 284
Query: 548 EGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEH-GVPTSVAFT 606
GH AV+GL PT L +CS D T RIWD + + + T S H +V
Sbjct: 285 HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA-----SVHTLSGHTNAVATVRCQ 339
Query: 607 STEPAHIVASFRSGDTV--LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD 664
+ EP I S DT L+D+ G +TL + S + VV HP T +
Sbjct: 340 AAEPQIITGSH---DTTIRLWDLVAGKTRVTLTNHKKS----VRAVVLHPRH-YTFASGS 391
Query: 665 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 724
I+ G + ++ H + L V+ +G L+SG+ + ++ LW Q +
Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRV 450
Query: 725 TAHRK----KHEEAIHAVACHPSKALIASAGADALAKVF 759
A + E I A A S++ + +A AD KV+
Sbjct: 451 HAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 79.7 bits (195), Expect = 9e-15
Identities = 74/293 (25%), Positives = 117/293 (39%), Gaps = 38/293 (12%)
Query: 427 SKDAFKKTWNPKFTLRS-----HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 481
S D F WN K R+ H D + S+ F + L +AS D T++LW K
Sbjct: 37 SWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFS 96
Query: 482 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 541
+ F+AH PV +V ++ ++ + D I W + Y
Sbjct: 97 E-----------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQR 135
Query: 542 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 601
L + L H V FSP + + SCS D T++IWD ++ C + G
Sbjct: 136 FL-YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ----CVNNFSDSVGFAN 190
Query: 602 SVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
V F + +AS S TV ++D+ V L + +N + HP+ I
Sbjct: 191 FVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHYQVHSGG----VNCISFHPSGNYLI 244
Query: 661 TAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
TA D ++ LD G+ ++++ H V ++ G SG D + LW
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/265 (18%), Positives = 101/265 (38%), Gaps = 24/265 (9%)
Query: 494 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDA 553
F+ H+ + ++ + N + + D + W + P ++ GH D
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62
Query: 554 VWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHI 613
V + FSP LAS S D TVR+W P F H P S + +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRG-----KFSEFKAHTAPVRSVDFSADGQFL 117
Query: 614 VASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDN 673
+ ++ M L +L + P+ L ++ +D+ I+ D
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRH----THWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 674 RTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEE 733
+ V++ + + +P+G + S D ++++W + V ++ H + H
Sbjct: 174 TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSG 229
Query: 734 AIHAVACHPSKALIASAGADALAKV 758
++ ++ HPS + +A +D K+
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 16/111 (14%)
Query: 421 SCDLSDSKDAFKKTWNPKFT-LRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 475
+C S D K W+ + L HY G+ ++FH S + L+TAS DGTLK+ +L
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL- 257
Query: 476 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
L+ I+ + H GPV V+ E SGGAD + W+
Sbjct: 258 ----------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 35.8 bits (81), Expect = 0.15
Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 685 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 744
H A+T L + PNG L + S D L LW+ H+ + + +V P
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72
Query: 745 ALIASAGADALAKVFV 760
L+ASA D ++++
Sbjct: 73 NLLASASRDRTVRLWI 88
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.3 bits (194), Expect = 1e-14
Identities = 78/303 (25%), Positives = 134/303 (44%), Gaps = 29/303 (9%)
Query: 460 LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD 519
LLTAS +KL + +N+ +AH P+ VA+ + +G D
Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113
Query: 520 ACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFS-PTSQRLASCSADGTVRIW 578
W D G + + LEGH + V+ +AF+ P ++A+ S D T ++W
Sbjct: 114 RTCKLW-------DTASGEE----LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 579 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSALLTL 636
S + C TF G + S P + + S DT L+D++ G + TL
Sbjct: 163 --SVETGKCYHTF-----RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 637 ESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDP 696
RG S +I + + + IT D + D TG+ V+ ++ H ++ + +
Sbjct: 216 --RGHSA--EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW 271
Query: 697 NGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALA 756
+ + +++GS D + +LW N CV +T H +E + + + K LIA+A AD A
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGH---DDEILDSCFDYTGK-LIATASADGTA 327
Query: 757 KVF 759
++F
Sbjct: 328 RIF 330
Score = 74.7 bits (182), Expect = 3e-13
Identities = 68/313 (21%), Positives = 118/313 (37%), Gaps = 37/313 (11%)
Query: 421 SCDLSDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQS-ALLTASEDGTLKLWNL 474
SC ++ S D K W+ TL H + + ++AF++ + T S D T KLW++
Sbjct: 105 SCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV 164
Query: 475 QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDP 534
+ + H FR H ++ ++ S +G D W I +
Sbjct: 165 ETG-----------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208
Query: 535 YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA 594
+ L GH + L+F+ + R+ + S D TV +WD + +
Sbjct: 209 ------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI---- 258
Query: 595 SEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHP 654
H S A + + + I+ L+D G + TL +I
Sbjct: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD----EILDSCFDY 313
Query: 655 NQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
L TA D R T K + + H ++ ++ +P G L++GS D + R+W
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 715 LDNKTCVQEITAH 727
C+Q + H
Sbjct: 374 AQTGQCLQVLEGH 386
Score = 72.8 bits (177), Expect = 1e-12
Identities = 66/320 (20%), Positives = 129/320 (40%), Gaps = 36/320 (11%)
Query: 441 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 500
L++H + ++A + S S +T S D T KLW+ E ++ HR
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASG-----------EELNTLEGHRNV 136
Query: 501 VLAVAMGS-NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 559
V A+A + + +G D W + + H GH + L+F
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSV-----------ETGKCYHTFRGHTAEIVCLSF 185
Query: 560 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 619
+P S +A+ S D T ++WD + + S++F ++ I SF
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEE----VYTLRGHSAEIISLSFNTSGDRIITGSF-D 240
Query: 620 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 679
V++D + G + L + +I+ + + L +T D+ + D GK V
Sbjct: 241 HTVVVWDADTGRKVNILIGHCA----EISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 680 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVA 739
++ H D + D G + + S D + R++S + C+ ++ + HE I ++
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL----EGHEGEISKIS 352
Query: 740 CHPSKALIASAGADALAKVF 759
+P + + +D A+++
Sbjct: 353 FNPQGNHLLTGSSDKTARIW 372
Score = 70.1 bits (170), Expect = 7e-12
Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 31/274 (11%)
Query: 440 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 499
T R H I L+F+ + + T S D T KLW++Q E ++ R H
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220
Query: 500 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 559
+++++ ++ + +G D + W D ++L GH + +F
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269
Query: 560 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 619
+ + + S D T ++WD ++ C+ T + + + +T I +
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKL---IATASAD 324
Query: 620 GDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPV 679
G ++ + LE G G +I+++ +P +T D+ R D +TG+ +
Sbjct: 325 GTARIFSAATRKCIAKLE--GHEG--EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 680 HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
+ H D + A + G +++GS D + R+W
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 79.0 bits (193), Expect = 2e-14
Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)
Query: 448 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 507
++ L+FH + +LT+ +G ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 508 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 545
SGG D I W D + ++ P +LS
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 546 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 596
VL GH V F PT + S S D TVR+WD S L S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 597 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 656
T V T A V +L RG +N HP
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217
Query: 657 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Query: 715 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ +T VQ R+ H+ +A HP+ L A AG D VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)
Query: 424 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
+S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 534
+ H V+ + S D + W I L ++ P
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
Query: 535 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 581
G +V+ HVLEGH V AF PT + S + D V+IW +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 582 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 641
S T H S A I+++ ++DM + + T
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288
Query: 642 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 685
+ + +HPN L HD I F R VH + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 79.0 bits (193), Expect = 2e-14
Identities = 85/345 (24%), Positives = 125/345 (36%), Gaps = 72/345 (20%)
Query: 448 IRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMG 507
++ L+FH + +LT+ +G ++LW+ + K F H GPV +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60
Query: 508 SNSEYCYSGGADACIHSWKIP------------DLSMDPYDGYD-PSVLSH--------- 545
SGG D I W D + ++ P +LS
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVW 120
Query: 546 ---------VLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 596
VL GH V F PT + S S D TVR+WD S L S+
Sbjct: 121 NWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESD 180
Query: 597 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 656
T V T A V +L RG +N HP
Sbjct: 181 VRGITGVDLFGTTDA-----------------VVKHVLEGHDRG------VNWAAFHPTM 217
Query: 657 PLTITAHDDRGIRF--LDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
PL ++ DDR ++ ++ V + H + V+C P ++S S D S+R+W
Sbjct: 218 PLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Query: 715 LDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ +T VQ R+ H+ +A HP+ L A AG D VF
Sbjct: 278 MSKRTGVQ---TFRRDHDR-FWVLAAHPNLNLFA-AGHDGGMIVF 317
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/286 (24%), Positives = 102/286 (35%), Gaps = 42/286 (14%)
Query: 424 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
+S D K WN K FTL H D IR+ FHH +L+AS+D T+++WN Q
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDL---SMDP- 534
+ H V+ + S D + W I L ++ P
Sbjct: 127 C-----------VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175
Query: 535 -------------YDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS 581
G +V+ HVLEGH V AF PT + S + D V+IW +
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 582 SSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGS 641
S T H S A I+++ ++DM + + T
Sbjct: 236 ESK---AWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFR---- 288
Query: 642 SGPTQINQVVSHPNQPLTITAHDDRGIRFL--DNRTGKPVHSMVAH 685
+ + +HPN L HD I F R VH + H
Sbjct: 289 RDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH 334
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 78.6 bits (192), Expect = 2e-14
Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 28/207 (13%)
Query: 462 TASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC 521
T S+DGT+KLW+++K I F+ + VLAV S+ SGG D
Sbjct: 169 TGSDDGTVKLWDIRKKAA-----------IQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
Query: 522 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-- 579
I W + + L++ + GH D+V GL+ S L S + D TVR+WD
Sbjct: 217 IKVWDLRQ-----------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Query: 580 PSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESR 639
P + C+ F + H ++ S P + S D +Y + S + +
Sbjct: 266 PFAPKERCVKIFQ-GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324
Query: 640 GSSGPTQINQVVSHPNQPLTITAHDDR 666
G +G IN+V HP++P+ I+A D+
Sbjct: 325 GHAG--SINEVAFHPDEPIIISASSDK 349
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 25/275 (9%)
Query: 490 PIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEG 549
PI H G V N S G D I W + D Y L+G
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----YGDCDNYA------TLKG 107
Query: 550 HGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTE 609
H AV L ++ L S S D TV +WD + H + + +
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERV-----KRLKGHTSFVNSCYPARR 162
Query: 610 PAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGI 668
+V + TV L+D+ +A+ T ++ Q+ V + I+ D I
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-----YQVLAVTFNDTSDQIISGGIDNDI 217
Query: 669 RFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL----DNKTCVQEI 724
+ D R K ++M H D+VT L++ G++L+S + D ++R+W + + CV+
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 725 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ E+ + + P + IA+ AD V+
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/333 (21%), Positives = 123/333 (36%), Gaps = 58/333 (17%)
Query: 437 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 496
P L H + FH + S L +A D + LWN+ D + +
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG----------DCDNYATLKG 107
Query: 497 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHV--LEGHGDAV 554
H G V+ + ++ +S D + W D V L+GH V
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVW-------------DSETGERVKRLKGHTSFV 154
Query: 555 ---WGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPA 611
+ P Q + + S DGTV++WD A + TF + +V F T
Sbjct: 155 NSCYPARRGP--QLVCTGSDDGTVKLWD--IRKKAAIQTFQNTYQ---VLAVTFNDTSD- 206
Query: 612 HIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFL 671
I++ D ++D+ T+ S + + ++ D +R
Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVW 262
Query: 672 DNRTGKP-----------VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
D R P VH+ +L + C + P+G+ + +GS D + +W ++
Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNL--LRC-SWSPDGSKIAAGSADRFVYVWDTTSRRI 319
Query: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGAD 753
+ ++ H +I+ VA HP + +I SA +D
Sbjct: 320 LYKLPG----HAGSINEVAFHPDEPIIISASSD 348
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 404 VSLGDLADLTVTN--DNDLSC-DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSAL 460
V+ D +D ++ DND+ DL +K + T+R H D + L+ S L
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTY--------TMRGHADSVTGLSLSSEGSYL 250
Query: 461 LTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADA 520
L+ + D T+++W+++ ++ + +H F + +L + + +G AD
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGSADR 307
Query: 521 CIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSAD 572
++ W D +L + L GH ++ +AF P + S S+D
Sbjct: 308 FVYVW----------DTTSRRIL-YKLPGHAGSINEVAFHPDEPIIISASSD 348
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 78.2 bits (191), Expect = 3e-14
Identities = 79/304 (25%), Positives = 125/304 (41%), Gaps = 37/304 (12%)
Query: 456 SQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYS 515
SQ L +ASED T++LW Q + + + A D R H GPV + ++ +
Sbjct: 2021 SQELLASASEDFTVQLWPRQ--LLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLAT 2078
Query: 516 GGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTV 575
GG D + W D P ++ H D V G A++ + L SCS+DG+V
Sbjct: 2079 GGRDRSLLCW-------DVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSV 2130
Query: 576 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLT 635
+WDP S G ++V+ + H+V+ R G ++D + G L +
Sbjct: 2131 GLWDPESGQRL-------GQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-GVELTS 2182
Query: 636 LESRGSSGPTQINQVVSHPN---QP----LTITAHDDRGIRFLDNRTGKPVHSMVAHLDA 688
+ + SGP P QP L +T D R H+++ H
Sbjct: 2183 IPAH--SGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
Query: 689 VTCLAVDPNGAFLMSGSHDCSLRLWSLDNK---TCVQEITAHRKKHEEAIHAVACHPSKA 745
V AV +++ S D S+RLW + + TC+ +A A+ AVA P +
Sbjct: 2241 VRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA-------AVTAVAWAPDGS 2293
Query: 746 LIAS 749
+ S
Sbjct: 2294 MAVS 2297
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/312 (22%), Positives = 129/312 (41%), Gaps = 49/312 (15%)
Query: 415 TNDNDLSCDLSDSKDAFKKTWNPKFTLR-----SHYDGIRSLAFHHSQSALLTASEDGTL 469
T DN L +S S D W+P+ R H + ++A + +++ S DGTL
Sbjct: 2116 TKDNLL---ISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA--VEEHVVSVSRDGTL 2170
Query: 470 KLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD 529
K+W+ Q + + AH GP+ A G++ + + +
Sbjct: 2171 KVWDHQGV------------ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDG 2218
Query: 530 LSMDPYDGYDPSVL--SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD-PSSSSPA 586
+ + P ++ +H L GH V A S TS + + S DG+VR+W P +
Sbjct: 2219 ATRL----WHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDT 2274
Query: 587 CLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQ 646
C+ P +S T+VA+ + + + V+ ++G+ +L+ + A+ T ++ G G
Sbjct: 2275 CI---PRSS--AAVTAVAW-APDGSMAVSGNQAGELILW--QEAKAVATAQAPGHIGAL- 2325
Query: 647 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAV--------TCLAVDPNG 698
+ S + ++A + + R G ++ HL+ + T L P+G
Sbjct: 2326 ---IWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDG 2382
Query: 699 AFLMSGSHDCSL 710
FL+ D L
Sbjct: 2383 HFLILAKADLKL 2394
Score = 46.2 bits (108), Expect = 1e-04
Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 49/306 (16%)
Query: 443 SHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHA--------- 493
+H+ + + F H+ LLTA EDG +++W+ +L + P +
Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
Query: 494 ----FRAH--------------RGPVLAVAMGS----NSEYCYSGGADACIHSWKIPDLS 531
+RA +G L VA+ + + + SG D + W + + S
Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001
Query: 532 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPS-SSSPACLCT 590
+ +L V GLA S + LAS S D TV++W + P
Sbjct: 2002 LQSL---------WLLSRFQKPVLGLATS--QELLASASEDFTVQLWPRQLLTRPHKAED 2050
Query: 591 FPTASE---HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQI 647
FP +E H P S ST+ + R + +D+ + + S + +
Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
Query: 648 NQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHD 707
+ L I+ D + D +G+ + + H AV+ +A ++S S D
Sbjct: 2111 TG-CAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRD 2167
Query: 708 CSLRLW 713
+L++W
Sbjct: 2168 GTLKVW 2173
Score = 33.9 bits (76), Expect = 0.58
Identities = 79/348 (22%), Positives = 130/348 (37%), Gaps = 49/348 (14%)
Query: 433 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIH 492
+TW + ++ S DGI + F + LTA DG L+LW+LQ + A +
Sbjct: 1706 RTWQEEKSVVSGCDGISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITG 1764
Query: 493 AFRAHRGPVLA-VAMGS----------------------NSEYCYSGGADACIHSWKIPD 529
+ +LA V +G N + G SW
Sbjct: 1765 CCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSW-AGS 1823
Query: 530 LSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLC 589
+S DG ++ L G ++ LAF+ +A D V +W + A L
Sbjct: 1824 ISFFQVDGLK---VTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW--AWREGARLA 1878
Query: 590 TFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 649
FP + HG + F ++ + G ++ +G RG G ++
Sbjct: 1879 AFP--AHHGFVAAALFLHA-GCQLLTAGEDGKVQVWSGSLG------RPRGHLGSLSLSP 1929
Query: 650 VVS---HPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA-VDPNGAFLMSGS 705
+S P+ + GIR +G A AV+ LA + P L+SG+
Sbjct: 1930 ALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK--VLVSGA 1987
Query: 706 HDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 753
D SL+ W+L K C + + ++ + +A S+ L+ASA D
Sbjct: 1988 EDGSLQGWAL--KECSLQSLWLLSRFQKPVLGLA--TSQELLASASED 2031
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.6 bits (187), Expect = 8e-14
Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 88/324 (27%)
Query: 458 SALLTASEDGT-LKLWNLQKAVTAKKNAALDVEPIHA---------------------FR 495
S LL A D + +KLW+L+ + +DV IH R
Sbjct: 280 SKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILR 339
Query: 496 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 555
H GPV + ++S S D I W + + +VL +GH VW
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--------GSFTNTVL---YQGHAYPVW 388
Query: 556 GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVA 615
L SP S AS S D T R+W +F T P I A
Sbjct: 389 DLDISPYSLYFASGSHDRTARLW-------------------------SFDRTYPLRIYA 423
Query: 616 SFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRT 675
+ ++ V HPN T D+ +R +
Sbjct: 424 GHLA--------------------------DVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAI 735
G V H V LA PNG +L S D L+LW L + T +E+ + H + I
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL----RGHTDNI 513
Query: 736 HAVACHPSKALIASAGADALAKVF 759
++ P LIASA D +V+
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVW 537
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/302 (22%), Positives = 105/302 (34%), Gaps = 74/302 (24%)
Query: 420 LSCDLSDSKDAFKKTWNPKFT-LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
L+CD+ + +D + LR H + S F S LL+ SED +++ W+L
Sbjct: 316 LACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 538
N L ++ H PV + + S Y SG D W +
Sbjct: 376 ----NTVL-------YQGHAYPVWDLDISPYSLYFASGSHDRTARLW-----------SF 413
Query: 539 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 598
D + + GH V + F P S LA+ S D TVR+W + L T G
Sbjct: 414 DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT----GHRG 469
Query: 599 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 658
S+AF+ PN
Sbjct: 470 PVLSLAFS-----------------------------------------------PNGKY 482
Query: 659 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 718
+A +D+ ++ D +G + H D +T L P+ + S S D S+R+W + N
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Query: 719 TC 720
C
Sbjct: 543 YC 544
Score = 33.1 bits (74), Expect = 0.99
Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 23/130 (17%)
Query: 407 GDLADLTVT----NDNDLSCDLSDSKDAFKKTW-----NPKFTLRSHYDGIRSLAFHHSQ 457
G LAD+ N N L+ + S D + W N H + SLAF +
Sbjct: 424 GHLADVDCVKFHPNSNYLA---TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480
Query: 458 SALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 517
L +A ED LKLW+L K+ R H + ++ +S S
Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKE-----------LRGHTDNITSLTFSPDSGLIASAS 529
Query: 518 ADACIHSWKI 527
D + W I
Sbjct: 530 MDNSVRVWDI 539
Score = 32.3 bits (72), Expect = 1.7
Identities = 16/64 (25%), Positives = 29/64 (45%)
Query: 441 LRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGP 500
LR H D I SL F + +AS D ++++W+++ + E + +
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565
Query: 501 VLAV 504
VL+V
Sbjct: 566 VLSV 569
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 74.3 bits (181), Expect = 4e-13
Identities = 86/343 (25%), Positives = 132/343 (38%), Gaps = 32/343 (9%)
Query: 423 DLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKK 482
D+ + K + + + KF +SH + R F L+T S DG +++WN T K
Sbjct: 195 DVEEEKFPTQLSRHIKFGQKSHVECAR---FSPDGQYLVTGSVDGFIEVWNF---TTGKI 248
Query: 483 NAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSV 542
L + F VL + ++E +G D I WKI
Sbjct: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS----------GQC 298
Query: 543 LSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTS 602
L H V L+FS S ++ S S D T+RI S T H +
Sbjct: 299 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVN 353
Query: 603 VAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSGPTQI--NQVVSHPNQPLT 659
A T T+ H + S S TV +++M+ T +S GS+ T I N V+ P P
Sbjct: 354 EA-TFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412
Query: 660 ITAHDDRGIRFLDNRTGKPVHSMVAHLDA---VTCLAVDPNGAFLMSGSHDCSLRLWSLD 716
+ + N G+ V S + C A+ P G ++ D L +S
Sbjct: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTV 472
Query: 717 NKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ +T H K + +A HP + LIA+ D L K++
Sbjct: 473 TGKLERTLTVHEKD----VIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 37.0 bits (84), Expect = 0.068
Identities = 35/179 (19%), Positives = 57/179 (31%), Gaps = 51/179 (28%)
Query: 442 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKA----------------VTAKKNAA 485
R H + F +++AS DGT+K+WN++ +T
Sbjct: 346 RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVIL 405
Query: 486 LDVEPIHAFRAHR------------------------GPVLAVAMGSNSEYCYSGGADAC 521
L P H +R G + A+ E+ Y G D
Sbjct: 406 LPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFV 465
Query: 522 IHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDP 580
++ + L L H V G+A P +A+ S DG +++W P
Sbjct: 466 LYCFSTVT-----------GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 73.9 bits (180), Expect = 5e-13
Identities = 81/335 (24%), Positives = 123/335 (36%), Gaps = 63/335 (18%)
Query: 429 DAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW----NLQKAVTAKKNA 484
DA KKT + + + +H ++L A +LW +L +A+ + A
Sbjct: 143 DALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVA------RLWIANYSLPRAMKRLEEA 196
Query: 485 ALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGAD-----------------ACIHS--- 524
L E R + L ++ S + +C G D AC
Sbjct: 197 RLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCK 256
Query: 525 -WKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQ--------RLASCSADGTV 575
W +PD + L H L GH V + F P S LASC+ADG+V
Sbjct: 257 LWSVPDCN-----------LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305
Query: 576 RIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV--LYDMEVGSAL 633
++W S P A G VA P+ D L+D+E +
Sbjct: 306 KLWSLDSDEPV-------ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 634 LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLA 693
L E + + H + L T D R D RTG+ + + HL + +
Sbjct: 359 LHQEGHSMG----VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414
Query: 694 VDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 728
PNG + +GS D + ++W L + CV I AH+
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449
Score = 47.4 bits (111), Expect = 5e-05
Identities = 69/330 (20%), Positives = 116/330 (35%), Gaps = 80/330 (24%)
Query: 392 DVFIMDTIGGGEVSLGDLA---DLTVTNDNDLSCDLSDSKDAFKKTWN-----PKFTLRS 443
D ++ T+ G ++G + TV+ D S + D K W+ P +
Sbjct: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321
Query: 444 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 503
H + + +H S L T D + +LW+L+ E I H V
Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-----------EEILHQEGHSMGVYD 370
Query: 504 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 563
+A + +GG DA W + + LEGH ++G+ FSP
Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF-----------LEGHLKEIYGINFSPNG 419
Query: 564 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV 623
+A+ S D T ++WD C + + + T V F EP H
Sbjct: 420 YHIATGSGDNTCKVWDLRQRR----CVYTIPAHQNLVTGVKF---EPIH----------- 461
Query: 624 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 683
G+ LLT G+ T ++ +HP P+ ++
Sbjct: 462 ------GNFLLT----GAYDNTA--KIWTHPGW--------------------SPLKTLA 489
Query: 684 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
H V L + +G + + S+D + +LW
Sbjct: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 73.2 bits (178), Expect = 9e-13
Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 26/241 (10%)
Query: 519 DACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 578
D+C+ W + P ++ GH DAV + FSP+ LAS S D TVRIW
Sbjct: 2 DSCLMVWHMK-----------PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
Query: 579 DPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LYDMEVGSALLTLE 637
P+ + + TA+ SV F S + + AS TV ++ L +L
Sbjct: 51 VPNVKGESTVFRAHTATVR----SVHFCSDGQSFVTAS--DDKTVKVWATHRQKFLFSL- 103
Query: 638 SRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPN 697
S + P+ L ++A DD+ ++ D + + VHS H VT + P+
Sbjct: 104 ---SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160
Query: 698 GAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAK 757
G + + D ++++W + +Q H + H A++ ++ HPS + +A +D+ K
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216
Query: 758 V 758
+
Sbjct: 217 I 217
Score = 63.9 bits (154), Expect = 5e-10
Identities = 65/292 (22%), Positives = 108/292 (36%), Gaps = 40/292 (13%)
Query: 429 DAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLW--NLQKAVTAK 481
D+ W+ K + H D + + F S L + S D T+++W N++ T
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
Query: 482 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 541
FRAH V +V S+ + + D + W
Sbjct: 61 ------------FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT-----------HRQ 97
Query: 542 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 601
L H + V FSP + + S S D TV++WD SS C G T
Sbjct: 98 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVT 153
Query: 602 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 661
V F + I A+ ++D+ L + ++ +N + HP+ IT
Sbjct: 154 YVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLHSAA----VNGLSFHPSGNYLIT 208
Query: 662 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
A D ++ LD G+ ++++ H T +A G + SG D + +W
Sbjct: 209 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 16/111 (14%)
Query: 421 SCDLSDSKDAFKKTWNPK-FTLRSHYD----GIRSLAFHHSQSALLTASEDGTLKLWNLQ 475
+C + D K W+ + L HY + L+FH S + L+TAS D TLK+ +L
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Query: 476 KAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
+ ++ H+GP VA EY SGG+D + WK
Sbjct: 222 EG-----------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 73.2 bits (178), Expect = 9e-13
Identities = 85/387 (21%), Positives = 142/387 (36%), Gaps = 86/387 (22%)
Query: 425 SDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 479
S S D + W+ P FT + H + S+++ L + ++G + LW+
Sbjct: 131 SGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ 190
Query: 480 AKKNAA--------LDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLS 531
+ A L EP+HA Y S D + W
Sbjct: 191 VGRTLAGHSKWITGLSWEPLHA-------------NPECRYVASSSKDGSVRIW------ 231
Query: 532 MDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTF 591
D G +L GH +V L + L S S D T+++W + LC
Sbjct: 232 -DTTAGR----CERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW---RAHDGVLCR- 281
Query: 592 PTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSS--------G 643
T HG + ST+ A +F + + ++ +L L+ R S G
Sbjct: 282 -TLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340
Query: 644 PTQ-------------------------------INQVVSHPNQPLTITAHDDRGIRFLD 672
P + INQV+ P+ + +A D+ I+ D
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Query: 673 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHE 732
RTGK + S+ H+ AV +A + L+SGS D +L++W + Q++ H
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----AQKLAMDLPGHA 456
Query: 733 EAIHAVACHPSKALIASAGADALAKVF 759
+ ++AV P +AS G D +++
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 72.4 bits (176), Expect = 1e-12
Identities = 53/183 (28%), Positives = 84/183 (45%), Gaps = 8/183 (4%)
Query: 547 LEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFT 606
LEGH +AV +AFSPT + LAS S D TVR WD S+ +P C H V S+++
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC---KGHRHWV-LSISW- 164
Query: 607 STEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHD-- 664
S + + + ++G +L+D G + + S T ++ H N A
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 665 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 724
D +R D G+ + H +VTCL +G L S S D ++++W + + +
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283
Query: 725 TAH 727
H
Sbjct: 284 QGH 286
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 16/107 (14%)
Query: 425 SDSKDAFKKTWNPKF-----TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 479
S S D K W+ + +LR H + +A+ L++ S D TLK+W+++
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA--- 445
Query: 480 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
+ A+D+ H V AV + + SGG D C+ W+
Sbjct: 446 --QKLAMDLP------GHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 38.1 bits (87), Expect = 0.031
Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 14/106 (13%)
Query: 624 LYDMEVGSAL-LTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSM 682
++D E+ S+L TLES+ + +V+ QP I F + S+
Sbjct: 64 VHDAEIVSSLGKTLESQA----VETEKVLDIIYQPQAI---------FRVRAVTRCTSSL 110
Query: 683 VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHR 728
H +AV +A P G +L SGS D ++R W L +T HR
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 71.6 bits (174), Expect = 2e-12
Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 22/187 (11%)
Query: 457 QSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPI-----HAFRAHRGPVLAVAMGSNSE 511
+S L+T S+D T+KLW L KA+ +K N A D PI R H + +VA+ N +
Sbjct: 434 ESFLVTGSQDCTVKLWPLPKALLSK-NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDK 492
Query: 512 YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSA 571
+G D W +P L V GH +W + FSP Q LA+ SA
Sbjct: 493 LLATGSQDRTAKLWALPQCQ-----------LLGVFSGHRRGLWCVQFSPMDQVLATASA 541
Query: 572 DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGS 631
DGT+++W S CL TF VAF S +++S G L+ ++
Sbjct: 542 DGTIKLWALQDFS--CLKTF--EGHDASVLKVAFVS-RGTQLLSSGSDGLVKLWTIKNNE 596
Query: 632 ALLTLES 638
+ TL++
Sbjct: 597 CVRTLDA 603
Score = 61.6 bits (148), Expect = 3e-09
Identities = 74/335 (22%), Positives = 127/335 (37%), Gaps = 43/335 (12%)
Query: 461 LTASEDGTLKLWNL---QKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGG 517
LTA + GTL++W Q T + E H AH V+ A ++ Y
Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322
Query: 518 A-----DACIHSWKIPDLS-MDPYDGY------DPSV--------LSHVLEGHGDAVWGL 557
+ +S ++ D+ + P D + P + +L GH D V L
Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL 382
Query: 558 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 617
ASC+ D +VRIW + + + H V T V + + + +V
Sbjct: 383 DVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGT-VCCSRLKESFLVTG- 440
Query: 618 RSGDTVLYDMEVGSALLTLESRGSSGP-------------TQINQVVSHPNQPLTITAHD 664
S D + + ALL+ + +GP IN V PN L T
Sbjct: 441 -SQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQ 499
Query: 665 DRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEI 724
DR + + + H + C+ P L + S D +++LW+L + +C++
Sbjct: 500 DRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559
Query: 725 TAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ H+ ++ VA + S+G+D L K++
Sbjct: 560 ----EGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 57.0 bits (136), Expect = 6e-08
Identities = 45/157 (28%), Positives = 60/157 (38%), Gaps = 27/157 (17%)
Query: 427 SKDAFKKTWN-PKFTL----RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAK 481
S+D K W P+ L H G+ + F L TAS DGT+KLW LQ
Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ------ 551
Query: 482 KNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPS 541
D + F H VL VA S S G+D + W I + +
Sbjct: 552 -----DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN-----------N 595
Query: 542 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 578
L+ H D VWGL S + ++D V +W
Sbjct: 596 ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 24/140 (17%)
Query: 440 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 499
T R H I S+A + L T S+D T KLW L + + + F HR
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQC-----------QLLGVFSGHRR 522
Query: 500 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLS-MDPYDGYDPSVLSHVLEGHGDAVWGLA 558
+ V + + AD I W + D S + ++G+D SVL +A
Sbjct: 523 GLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLK------------VA 570
Query: 559 FSPTSQRLASCSADGTVRIW 578
F +L S +DG V++W
Sbjct: 571 FVSRGTQLLSSGSDGLVKLW 590
Score = 50.8 bits (120), Expect = 5e-06
Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 40/356 (11%)
Query: 425 SDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 479
S + DA + W+ + L +HY + SLAF +L++ D +W+LQ +
Sbjct: 170 SSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-SCQ 228
Query: 480 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYD 539
A + + A PV + + S Y + G + W+ Y
Sbjct: 229 ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAAS-GQCVYTQAQ 287
Query: 540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 599
P G G + + T+ + + +AD + +++ + S F SE +
Sbjct: 288 P-------PGPGQELTHCTLAHTAGVVLTATADHNLLLYE--ARSLRLQKQFAGYSEEVL 338
Query: 600 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQP-L 658
V F E +H+V + S +++++ + + G T I + + L
Sbjct: 339 --DVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL------HGHTDIVLALDVFRKGWL 390
Query: 659 TITAHDDRGIR-FLDNRTGKP--VHSMVAHLDAV-TCLAVDPNGAFLMSGSHDCSLRLWS 714
+ D+ +R + N+ G+ V H +V T +FL++GS DC+++LW
Sbjct: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWP 450
Query: 715 L-----------DNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
L DN + + ++ H++ I++VA P+ L+A+ D AK++
Sbjct: 451 LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
Score = 44.7 bits (104), Expect = 3e-04
Identities = 78/365 (21%), Positives = 119/365 (32%), Gaps = 72/365 (19%)
Query: 444 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 503
H + ++AF + + L T DG +++W++ + H FR G V
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGT-----------HHFRGSPGVVHL 156
Query: 504 VAMGSNSE--YCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSP 561
VA + +S DA I W + D S VL H AV LAFS
Sbjct: 157 VAFHPDPTRLLLFSSATDAAIRVWSLQDRSC-----------LAVLTAHYSAVTSLAFSA 205
Query: 562 TSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV-----PTSVAFTSTEPAHIVAS 616
+ S D IWD S + E V P S + + + +
Sbjct: 206 DGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265
Query: 617 FRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSH-PNQPLTITA------HDDRGIR 669
G +++ G + T G + ++H LT TA ++ R +R
Sbjct: 266 GDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLR 325
Query: 670 F-----------LDNRTGKPVHSMV-----------------------AHLDAVTCLAVD 695
LD R P S V H D V L V
Sbjct: 326 LQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVF 385
Query: 696 PNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK-ALIASAGADA 754
G S + D S+R+W + NK A H ++ V C K + + + D
Sbjct: 386 RKGWLFASCAKDQSVRIWRM-NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDC 444
Query: 755 LAKVF 759
K++
Sbjct: 445 TVKLW 449
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 71.2 bits (173), Expect = 3e-12
Identities = 70/273 (25%), Positives = 113/273 (41%), Gaps = 36/273 (13%)
Query: 444 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 503
H D + FH S L T+S D T+KLW+L K + I F H V +
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG-----------DCILTFEGHSRAVWS 441
Query: 504 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 563
S + S D W + + L GH D+V + F P S
Sbjct: 442 CTWHSCGNFVASSSLDKTSKIWDV-----------NSERCRCTLYGHTDSVNSIEFFPFS 490
Query: 564 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIVASFRS-GD 621
L + SAD T+ IWD + +C S +G S+ +P H++AS + G
Sbjct: 491 NTLLTSSADKTLSIWDARTG----IC---EQSLYGHMHSINDAIFDPRGHMIASCDACGV 543
Query: 622 TVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 681
T L+D +++++ GP+ N+V + + A + I LD ++G+ +H
Sbjct: 544 TKLWDFRKLLPIVSID----IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHK 598
Query: 682 MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
++ H + + +G L SG D ++R WS
Sbjct: 599 LMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 55.8 bits (133), Expect = 1e-07
Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 38/250 (15%)
Query: 473 NLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSM 532
NL + + A D + + FR H PV V+M + + S G D WK+ L
Sbjct: 327 NLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRL---WKVLGLPK 383
Query: 533 DPYDGYDPSVLSHVLEGHGDAVW--GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCT 590
+ +L G G W F P+ +LA+ S D TV++WD C+ T
Sbjct: 384 ----------CNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILT 431
Query: 591 FPTASE-------HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSG 643
F S H VA +S + + ++D+ TL S
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKT----------SKIWDVNSERCRCTLYGHTDS- 480
Query: 644 PTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 703
+N + P +T+ D+ + D RTG S+ H+ ++ DP G + S
Sbjct: 481 ---VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIAS 537
Query: 704 GSHDCSLRLW 713
+LW
Sbjct: 538 CDACGVTKLW 547
Score = 38.5 bits (88), Expect = 0.023
Identities = 50/191 (26%), Positives = 72/191 (37%), Gaps = 50/191 (26%)
Query: 425 SDSKDAFKKTWNP-----KFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVT 479
S S D K W+ + TL H D + S+ F + LLT+S D TL +W+ + +
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 480 AKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADAC--IHSWK----IPDLSMD 533
+ A RG ++A DAC W +P +S+D
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIA-------------SCDACGVTKLWDFRKLLPIVSID 559
Query: 534 --PYDG----YDPS--VLS------------------HVLEGHGDAVWGLAFSPTSQRLA 567
P G +D S VL+ H L GH + + FS + L
Sbjct: 560 IGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILF 619
Query: 568 SCSADGTVRIW 578
S +DGTVR W
Sbjct: 620 SGGSDGTVRTW 630
Score = 36.2 bits (82), Expect = 0.12
Identities = 23/113 (20%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 647 INQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSH 706
++ V P++ + ++ +DR + L + + H D ++ P+G L + S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 707 DCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
D +++LW L C+ H + A+ + H +AS+ D +K++
Sbjct: 415 DTTVKLWDLCKGDCILTFEGHSR----AVWSCTWHSCGNFVASSSLDKTSKIW 463
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 71.2 bits (173), Expect = 3e-12
Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 37/316 (11%)
Query: 442 RSHYDGIRSLAF----HHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAH 497
++H D I S+A+ + ++T S D +K+W ++ LD++ + H
Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGH 63
Query: 498 RGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGL 557
+ V++V + S DA I W + + + + G DA W L
Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQ----------IKSIDAGPVDA-WTL 112
Query: 558 AFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASF 617
AFSP SQ LA+ + G V I+ S + + S+A+ S + ++ +
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKE----YSLDTRGKFILSIAY-SPDGKYLASGA 167
Query: 618 RSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 677
G ++D+ G L TLE G + P I + P+ L +TA DD I+ D +
Sbjct: 168 IDGIINIFDIATGKLLHTLE--GHAMP--IRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223
Query: 678 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHA 737
++ H V +A P+ +S S D S+++W + +TCV H++ +
Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF----DHQDQVWG 279
Query: 738 VACHPSKALIASAGAD 753
V + + + I S G D
Sbjct: 280 VKYNGNGSKIVSVGDD 295
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/297 (20%), Positives = 124/297 (41%), Gaps = 38/297 (12%)
Query: 424 LSDSKDAFKKTW-------NPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQK 476
++ S D K W + +++L H G+ S+ H+ ++S D ++LW+L+
Sbjct: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
Query: 477 AVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYD 536
K+ ++D P+ A+ +A +S+Y +G H K+
Sbjct: 96 G---KQIKSIDAGPVDAW--------TLAFSPDSQYLATG-----THVGKVNIF------ 133
Query: 537 GYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASE 596
G + + L+ G + +A+SP + LAS + DG + I+D ++ T
Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK-----LLHTLEG 188
Query: 597 HGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQ 656
H +P S + +V + G +YD++ + TL S + V P+
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHAS----WVLNVAFCPDD 244
Query: 657 PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
+++ D+ ++ D T VH+ H D V + + NG+ ++S D + ++
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 22/140 (15%)
Query: 440 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 499
TL H IRSL F L+TAS+DG +K++++Q A A H
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA-----------GTLSGHAS 233
Query: 500 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 559
VL VA + + S +D + W + H H D VWG+ +
Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDV-----------GTRTCVHTFFDHQDQVWGVKY 282
Query: 560 SPTSQRLASCSADGTVRIWD 579
+ ++ S D + I+D
Sbjct: 283 NGNGSKIVSVGDDQEIHIYD 302
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 70.9 bits (172), Expect = 4e-12
Identities = 70/301 (23%), Positives = 126/301 (41%), Gaps = 34/301 (11%)
Query: 424 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAV 478
L+ S+D W + + L H ++ F +AS D T++LW++ +A
Sbjct: 37 LTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARA- 95
Query: 479 TAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGY 538
+ + + H+ V V+ +S SGG D + W + M
Sbjct: 96 ----------KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM------ 139
Query: 539 DPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHG 598
+L GH D++ FSPT LA+ S D TV IWD +PA + G
Sbjct: 140 -----LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA----VSHQALEG 190
Query: 599 VPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPL 658
+++ + ++AS S D ++ + ++ L ++ +G T + + P++
Sbjct: 191 HSANISCLCYSASGLLAS-GSWDKTIHIWKPTTSSLLIQLKGH--VTWVKSIAFSPDELW 247
Query: 659 TITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 718
+A R ++ D TGK + ++ LD A P+G L+SG+ D + R S +K
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
Query: 719 T 719
+
Sbjct: 308 S 308
Score = 67.0 bits (162), Expect = 6e-11
Identities = 70/279 (25%), Positives = 107/279 (38%), Gaps = 28/279 (10%)
Query: 484 AALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVL 543
A L V + F H G V + A + + +G D C++ W+ L
Sbjct: 7 ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRS-----------GQL 55
Query: 544 SHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSV 603
L GH V FSP AS S D TVR+WD + + CL + V T V
Sbjct: 56 LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAK--CLRVL-KGHQRSVET-V 111
Query: 604 AFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAH 663
+F S + + + +L+D++ G L L S I P T
Sbjct: 112 SF-SPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS----IQSSDFSPTVNCLATGS 166
Query: 664 DDRGIRFLDNRTGKPV---HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTC 720
D + D R P ++ H ++CL +G L SGS D ++ +W K
Sbjct: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIW----KPT 221
Query: 721 VQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
+ K H + ++A P + +ASAG + KV+
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 60.1 bits (144), Expect = 8e-09
Identities = 62/310 (20%), Positives = 109/310 (35%), Gaps = 33/310 (10%)
Query: 444 HYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLA 503
H + S AF LLT SEDG + W + + + H GPV
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-----------QLLWRLGGHTGPVKF 68
Query: 504 VAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTS 563
+ S D + W + VL+GH +V ++FSP S
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVARAKC-----------LRVLKGHQRSVETVSFSPDS 117
Query: 564 QRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV 623
++LAS D V +WD S L G S+ + P + S D+
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLV-------GHRDSIQSSDFSPTVNCLATGSWDST 170
Query: 624 LYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMV 683
++ ++ + + G + + + L + D+ I T + +
Sbjct: 171 VHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLK 230
Query: 684 AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPS 743
H+ V +A P+ +L S + +++W + C++ + K + H A P
Sbjct: 231 GHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL----KGVLDVAHTCAFTPD 286
Query: 744 KALIASAGAD 753
++ S AD
Sbjct: 287 GKILVSGAAD 296
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,333,983
Number of Sequences: 37866
Number of extensions: 2101573
Number of successful extensions: 29715
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 456
Number of HSP's successfully gapped in prelim test: 765
Number of HSP's that attempted gapping in prelim test: 17077
Number of HSP's gapped (non-prelim): 9703
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.