Search of human proteins with 8924248

Search of human proteins with 8924248

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8924248 SRY-box 18 [Homo sapiens]
         (384 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8924248 SRY-box 18 [Homo sapiens]                                  800   0.0  
gi|11967991 SRY-box 17 [Homo sapiens]                                 243   2e-64
gi|13899269 SRY-box 7 [Homo sapiens]                                  222   4e-58
gi|4557853 transcription factor SOX9 [Homo sapiens]                   128   1e-29
gi|30061556 SRY (sex determining region Y)-box 3 [Homo sapiens]       124   1e-28
gi|5902106 SRY-box 15 [Homo sapiens]                                  123   3e-28
gi|28195386 sex-determining region Y-box 2 [Homo sapiens]             122   4e-28
gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens]       122   7e-28
gi|5902104 SRY (sex determining region Y)-box 10 [Homo sapiens]       121   1e-27
gi|30179900 SRY (sex determining region Y)-box 1 [Homo sapiens]       121   1e-27
gi|4759162 SRY-box 14 [Homo sapiens]                                  120   2e-27
gi|21264339 SRY (sex determining region Y)-box 12 [Homo sapiens]      115   7e-26
gi|5902108 SRY-box 21 [Homo sapiens]                                  113   3e-25
gi|4507161 SRY-box 11 [Homo sapiens]                                  111   1e-24
gi|4507163 SRY (sex determining region Y)-box 4 [Homo sapiens]        110   2e-24
gi|224967054 SRY (sex determining region Y)-box 6 isoform 4 [Hom...   104   2e-22
gi|224967050 SRY (sex determining region Y)-box 6 isoform 3 [Hom...   104   2e-22
gi|70909338 SRY (sex determining region Y)-box 6 isoform 1 [Homo...   104   2e-22
gi|71037389 SRY (sex determining region Y)-box 6 isoform 2 [Homo...   104   2e-22
gi|30061558 SRY (sex determining region Y)-box 5 isoform c [Homo...   103   2e-22
gi|23308715 SRY (sex determining region Y)-box 5 isoform b [Homo...   103   2e-22
gi|23308713 SRY (sex determining region Y)-box 5 isoform a [Homo...   103   2e-22
gi|41406089 SRY-box 13 [Homo sapiens]                                 103   2e-22
gi|4507225 sex determining region Y [Homo sapiens]                    100   2e-21
gi|30581117 SRY (sex determining region Y)-box 30 isoform a [Hom...    80   4e-15
gi|5902112 SRY (sex determining region Y)-box 30 isoform b [Homo...    79   7e-15
gi|112421108 capicua homolog [Homo sapiens]                            68   1e-11
gi|198442849 transcription factor 7 (T-cell specific, HMG-box) 5...    63   5e-10
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    61   2e-09
gi|217035121 HMG-BOX transcription factor BBX isoform 1 [Homo sa...    60   3e-09

>gi|8924248 SRY-box 18 [Homo sapiens]
          Length = 384

 Score =  800 bits (2066), Expect = 0.0
 Identities = 384/384 (100%), Positives = 384/384 (100%)

Query: 1   MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPR 60
           MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPR
Sbjct: 1   MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPR 60

Query: 61  SPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLG 120
           SPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLG
Sbjct: 61  SPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLG 120

Query: 121 KAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPP 180
           KAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPP
Sbjct: 121 KAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPP 180

Query: 181 QPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDC 240
           QPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDC
Sbjct: 181 QPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDC 240

Query: 241 ALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPP 300
           ALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPP
Sbjct: 241 ALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPP 300

Query: 301 PEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCP 360
           PEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCP
Sbjct: 301 PEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCP 360

Query: 361 EESSLISALSDASSAVYYSACISG 384
           EESSLISALSDASSAVYYSACISG
Sbjct: 361 EESSLISALSDASSAVYYSACISG 384


>gi|11967991 SRY-box 17 [Homo sapiens]
          Length = 414

 Score =  243 bits (621), Expect = 2e-64
 Identities = 178/420 (42%), Positives = 218/420 (51%), Gaps = 78/420 (18%)

Query: 23  APGHGAAADTRGL--AAGPAALAA--PAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQ 78
           +P  G A+D +    +A PA +A   P   A   SP        E      +PAG   R 
Sbjct: 3   SPDAGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGR- 61

Query: 79  AADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEA 138
           A  ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNA LSKMLGK+WK L  AEKRPFVEEA
Sbjct: 62  AKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEA 121

Query: 139 ERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQP---------------- 182
           ERLRVQH++DHPNYKYRPRR+KQ ++ +R+E G  L GLA PQ                 
Sbjct: 122 ERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGG-FLHGLAEPQAAALGPEGGRVAMDGLG 180

Query: 183 ---PPEPFPAA-----SGSARAFRELPPLGA-EFDGLGLPTPERSPLDGLEPGEAAFFPP 233
              P + FPA            +R+   LGA   DG  LPTP+ SPLDG++P + AFF  
Sbjct: 181 LQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPLPTPDTSPLDGVDP-DPAFFAA 239

Query: 234 PAAPEDCALRPFRAPYAPTELS--RDPGGCYGAPLAEALRTAPPAAPLAGL--------- 282
           P  P DC   P    Y+  ++S    P      P+   L   P    + GL         
Sbjct: 240 P-MPGDC---PAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLLAPPSALHV 295

Query: 283 YYGTLGTPG-----------------------PYPGPLSPPPEAPPLESAEPLGPAADLW 319
           YYG +G+PG                       P PG  SPPPEA P          A+L 
Sbjct: 296 YYGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTDPSQPAELL 355

Query: 320 ADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLISA-LSDASSAVYY 378
            +VD TEF+QYL+    +P+  GLPY     +     ++ P+    IS+ +SDASSAVYY
Sbjct: 356 GEVDRTEFEQYLHFV-CKPEM-GLPY-----QGHDSGVNLPDSHGAISSVVSDASSAVYY 408


>gi|13899269 SRY-box 7 [Homo sapiens]
          Length = 388

 Score =  222 bits (566), Expect = 4e-58
 Identities = 171/411 (41%), Positives = 209/411 (50%), Gaps = 81/411 (19%)

Query: 30  ADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPM 89
           A   G    P  L  PA  A     Q SPP  P P      P  +G      ESRIRRPM
Sbjct: 2   ASLLGAYPWPEGLECPALDAELSDGQ-SPPAVPRP------PGDKGS-----ESRIRRPM 49

Query: 90  NAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDH 149
           NAFMVWAKDERKRLA QNPDLHNA LSKMLGK+WK L  ++KRP+V+EAERLR+QH++D+
Sbjct: 50  NAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDY 109

Query: 150 PNYKYRPRRKKQARK-ARRLEPGLLLPGLAPPQPP-PEPFPAASGSARAFRE-------- 199
           PNYKYRPRRKKQA++  +R++PG LL  L+  Q   PE     SGS  A  E        
Sbjct: 110 PNYKYRPRRKKQAKRLCKRVDPGFLLSSLSRDQNALPE---KRSGSRGALGEKEDRGEYS 166

Query: 200 ----LPPL-GAEFDG-----------------LGLPT-PERSPLDGLEPGEAAFFPPPAA 236
               LP L G   +G                  GLPT PE SPLD LEP E  FF  P  
Sbjct: 167 PGTALPSLRGCYHEGPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEP-EQTFFSSPCQ 225

Query: 237 PEDCALR--------PFRAPYAPTEL-SRDPGG--CYGAPLAEALRTAPPAAPLAGLYYG 285
            E    R        P+   YAP+ L    P G    G     ++ +  P  P +  YY 
Sbjct: 226 EEHGHPRRIPHLPGHPYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPGCPPSPAYY- 284

Query: 286 TLGTPGPYP----------GPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSR 335
              +P  Y           G LSPPPE P  ++ + L    +L  D+D  EFDQYLN   
Sbjct: 285 ---SPATYHPLHSNLQAHLGQLSPPPEHPGFDALDQLS-QVELLGDMDRNEFDQYLNTPG 340

Query: 336 TRPDAPG---LPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACIS 383
               A G   L  HV ++++ P     P E+SLIS L+DA++  Y S  +S
Sbjct: 341 HPDSATGAMALSGHVPVSQVTPTG---PTETSLISVLADATATYYNSYSVS 388


>gi|4557853 transcription factor SOX9 [Homo sapiens]
          Length = 509

 Score =  128 bits (321), Expect = 1e-29
 Identities = 92/273 (33%), Positives = 123/273 (45%), Gaps = 45/273 (16%)

Query: 81  DESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAER 140
           ++  ++RPMNAFMVWA+  R++LA Q P LHNA LSK LGK W+ LN +EKRPFVEEAER
Sbjct: 101 NKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAER 160

Query: 141 LRVQHLRDHPNYKYRPRRKK----------QARKARRLEPGLLLPGLAPPQPPPEPFPAA 190
           LRVQH +DHP+YKY+PRR+K          +A +   + P  +   L    P      ++
Sbjct: 161 LRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSP-----HSS 215

Query: 191 SGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAF-----------FPPPAAPED 239
           SG +       P        G PTP  +P   ++PG+A               PP    D
Sbjct: 216 SGMSEVH---SPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRD 272

Query: 240 CALRPFRAPYAPTELSRD---------PGGCYGAPLAEALRT-------APPAAPLAGLY 283
             +    +       + D         P G  G P      T       +  AA  A   
Sbjct: 273 VDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAG 332

Query: 284 YGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAA 316
           +  +      P P   PP+APP   A P   AA
Sbjct: 333 HVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQAA 365



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 11/19 (57%), Positives = 14/19 (73%)

Query: 44  APAAPASPPSPQRSPPRSP 62
           AP AP +PP PQ +PP+ P
Sbjct: 352 APPAPQAPPQPQAAPPQQP 370


>gi|30061556 SRY (sex determining region Y)-box 3 [Homo sapiens]
          Length = 446

 Score =  124 bits (311), Expect = 1e-28
 Identities = 74/206 (35%), Positives = 107/206 (51%), Gaps = 15/206 (7%)

Query: 6   PGYGAQDDPPARRDCAWAPGHGAAADT--RGLAAGPAALAAPAAPASPPSPQRSPPRSPE 63
           P  GA   P        AP   +  +T  +     P   A    PA+P    +S   +  
Sbjct: 56  PAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAG 115

Query: 64  PGRYGLSPAG--RGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGK 121
               G   +G   G     D+ R++RPMNAFMVW++ +R+++A +NP +HN+ +SK LG 
Sbjct: 116 GANSGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGA 175

Query: 122 AWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQA---RKARRLEPGLLLPGLA 178
            WK L  AEKRPF++EA+RLR  H++++P+YKYRPRRK +    +    L  GLL PG A
Sbjct: 176 DWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAA 235

Query: 179 PPQPPPEPFPAASGSARAFRELPPLG 204
                     AA+ +A A     P+G
Sbjct: 236 A--------AAAAAAAAAAAASSPVG 253


>gi|5902106 SRY-box 15 [Homo sapiens]
          Length = 233

 Score =  123 bits (308), Expect = 3e-28
 Identities = 73/176 (41%), Positives = 98/176 (55%), Gaps = 14/176 (7%)

Query: 27  GAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIR 86
           G++ D       PAA AA A+ +S P  +        PG   L              +++
Sbjct: 5   GSSQDQAWSLEPPAATAA-ASSSSGPQEREGAGSPAAPGTLPLE-------------KVK 50

Query: 87  RPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHL 146
           RPMNAFMVW+  +R+++AQQNP +HN+ +SK LG  WK L+  EKRPFVEEA+RLR +HL
Sbjct: 51  RPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHL 110

Query: 147 RDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPP 202
           RD+P+YKYRPRRK ++  A     G     LA   P   P  A +  +R F   PP
Sbjct: 111 RDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPP 166


>gi|28195386 sex-determining region Y-box 2 [Homo sapiens]
          Length = 317

 Score =  122 bits (307), Expect = 4e-28
 Identities = 59/129 (45%), Positives = 84/129 (65%), Gaps = 7/129 (5%)

Query: 51  PPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDL 110
           PP PQ++       G    + A  G  Q     R++RPMNAFMVW++ +R+++AQ+NP +
Sbjct: 11  PPGPQQTSGG----GGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKM 66

Query: 111 HNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQA---RKARR 167
           HN+ +SK LG  WK L+  EKRPF++EA+RLR  H+++HP+YKYRPRRK +    +    
Sbjct: 67  HNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYT 126

Query: 168 LEPGLLLPG 176
           L  GLL PG
Sbjct: 127 LPGGLLAPG 135


>gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens]
          Length = 446

 Score =  122 bits (305), Expect = 7e-28
 Identities = 71/153 (46%), Positives = 90/153 (58%), Gaps = 4/153 (2%)

Query: 12  DDPPARRDCAWAPGHGAAADTRGLAAG-PAALAAPAAPASPPSPQRSPPRSPEPGRYGLS 70
           D PP+    A + G G A    G A G PA  A    PA          +  +     + 
Sbjct: 31  DAPPSP---AGSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMP 87

Query: 71  PAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAE 130
             G G      +  ++RPMNAFMVWA+  R++LA Q P LHNA LSK LGK W+ L+ +E
Sbjct: 88  VRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESE 147

Query: 131 KRPFVEEAERLRVQHLRDHPNYKYRPRRKKQAR 163
           KRPFVEEAERLRVQH +DHP+YKY+PRR+K A+
Sbjct: 148 KRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAK 180



 Score = 28.9 bits (63), Expect = 8.1
 Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 8/54 (14%)

Query: 26  HGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPR------SPEPGRYGLSPAG 73
           +G A    G +   A  +AP+A ASP   +  PPR       P PG YG  P G
Sbjct: 303 YGGAYFHAGASPVWAHKSAPSASASPT--ETGPPRPHIKTEQPSPGHYGDQPRG 354


>gi|5902104 SRY (sex determining region Y)-box 10 [Homo sapiens]
          Length = 466

 Score =  121 bits (303), Expect = 1e-27
 Identities = 70/154 (45%), Positives = 90/154 (58%), Gaps = 13/154 (8%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           ++RPMNAFMVWA+  R++LA Q P LHNA LSK LGK W+ LN ++KRPF+EEAERLR+Q
Sbjct: 104 VKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQ 163

Query: 145 HLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLG 204
           H +DHP+YKY+PRR+K  + A   +     PG    Q       A   SA      P  G
Sbjct: 164 HKKDHPDYKYQPRRRKNGKAA---QGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEG 220

Query: 205 AEF-DG---------LGLPTPERSPLDGLEPGEA 228
           +   DG          G PTP  +P   L+ G+A
Sbjct: 221 SPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKA 254


>gi|30179900 SRY (sex determining region Y)-box 1 [Homo sapiens]
          Length = 391

 Score =  121 bits (303), Expect = 1e-27
 Identities = 59/134 (44%), Positives = 86/134 (64%), Gaps = 4/134 (2%)

Query: 47  APASPPSPQR-SPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQ 105
           +P    +P   S P     G  G    G G    A++ R++RPMNAFMVW++ +R+++AQ
Sbjct: 12  SPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQ 71

Query: 106 QNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQA--- 162
           +NP +HN+ +SK LG  WK ++ AEKRPF++EA+RLR  H+++HP+YKYRPRRK +    
Sbjct: 72  ENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLK 131

Query: 163 RKARRLEPGLLLPG 176
           +    L  GLL  G
Sbjct: 132 KDKYSLAGGLLAAG 145



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 32/95 (33%), Positives = 39/95 (41%), Gaps = 17/95 (17%)

Query: 1   MQRSPPGYG----------AQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPAS 50
           M  SP GYG          A     A ++ A A    AAA + G      +L       S
Sbjct: 266 MSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGS 325

Query: 51  PPSPQRSPPRSPEPG--RYGLS---PAGRGERQAA 80
           PP+P  S  R+P PG  R  +S   PAG G   AA
Sbjct: 326 PPAPAHS--RAPCPGDLREMISMYLPAGEGGDPAA 358


>gi|4759162 SRY-box 14 [Homo sapiens]
          Length = 240

 Score =  120 bits (301), Expect = 2e-27
 Identities = 70/155 (45%), Positives = 98/155 (63%), Gaps = 29/155 (18%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           I+RPMNAFMVW++ +R+++AQ+NP +HN+ +SK LG  WK L+ AEKRP+++EA+RLR Q
Sbjct: 8   IKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQ 67

Query: 145 HLRDHPNYKYRPRRKKQ--ARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPP 202
           H+++HP+YKYRPRRK +   +K R + P   LP L       +P  AA           P
Sbjct: 68  HMKEHPDYKYRPRRKPKNLLKKDRYVFP---LPYLG----DTDPLKAAG---------LP 111

Query: 203 LGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAP 237
           +GA  DGL L  PE++          AF PP +AP
Sbjct: 112 VGAS-DGL-LSAPEKA---------RAFLPPASAP 135


>gi|21264339 SRY (sex determining region Y)-box 12 [Homo sapiens]
          Length = 315

 Score =  115 bits (288), Expect = 7e-26
 Identities = 61/135 (45%), Positives = 82/135 (60%), Gaps = 22/135 (16%)

Query: 59  PRSPEPGRYGLSPAGRGERQAA----DESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAV 114
           P  P PG     PA  G R+          I+RPMNAFMVW++ ER+++  Q PD+HNA 
Sbjct: 15  PPPPGPG-----PAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAE 69

Query: 115 LSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKAR-------- 166
           +SK LG+ W+ L  +EK PFV EAERLR++H+ D+P+YKYRPR+K +   A+        
Sbjct: 70  ISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGG 129

Query: 167 -----RLEPGLLLPG 176
                RL+PG  LPG
Sbjct: 130 SGGGSRLKPGPQLPG 144


>gi|5902108 SRY-box 21 [Homo sapiens]
          Length = 276

 Score =  113 bits (282), Expect = 3e-25
 Identities = 77/212 (36%), Positives = 112/212 (52%), Gaps = 26/212 (12%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           ++RPMNAFMVW++ +R+++AQ+NP +HN+ +SK LG  WK L  +EKRPF++EA+RLR  
Sbjct: 8   VKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAM 67

Query: 145 HLRDHPNYKYRPRRK-----KQARKARRLEPGLLLPGLAPPQPPPEPFPAASG-SARAFR 198
           H+++HP+YKYRPRRK     K+ + A  +  G  L G+A  + P     A +G  A A  
Sbjct: 68  HMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYG--LGGVADAEHP--ALKAGAGLHAGAGG 123

Query: 199 ELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRA--PYAPTELSR 256
            L P         L  PE++           FFP  AA    A     A  PY+  +L  
Sbjct: 124 GLVPESL------LANPEKAAAAAAAAAARVFFPQSAAAAAAAAAAAAAGSPYSLLDL-- 175

Query: 257 DPGGCYGAPLAEALRTAPPAAPLAGLYYGTLG 288
                 G+ +AE   ++      + L Y T G
Sbjct: 176 ------GSKMAEISSSSSGLPYASSLGYPTAG 201


>gi|4507161 SRY-box 11 [Homo sapiens]
          Length = 441

 Score =  111 bits (278), Expect = 1e-24
 Identities = 47/75 (62%), Positives = 64/75 (85%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           I+RPMNAFMVW+K ER+++ +Q+PD+HNA +SK LGK WK L  +EK PF+ EAERLR++
Sbjct: 49  IKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLK 108

Query: 145 HLRDHPNYKYRPRRK 159
           H+ D+P+YKYRPR+K
Sbjct: 109 HMADYPDYKYRPRKK 123


>gi|4507163 SRY (sex determining region Y)-box 4 [Homo sapiens]
          Length = 474

 Score =  110 bits (276), Expect = 2e-24
 Identities = 52/108 (48%), Positives = 76/108 (70%), Gaps = 4/108 (3%)

Query: 61  SPEPGRYGLSPAGRGERQA---ADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSK 117
           SP PG    S  G+ +  +        I+RPMNAFMVW++ ER+++ +Q+PD+HNA +SK
Sbjct: 33  SPTPGSTA-STGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISK 91

Query: 118 MLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKA 165
            LGK WK L  ++K PF+ EAERLR++H+ D+P+YKYRPR+K ++  A
Sbjct: 92  RLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGNA 139


>gi|224967054 SRY (sex determining region Y)-box 6 isoform 4 [Homo
           sapiens]
          Length = 841

 Score =  104 bits (259), Expect = 2e-22
 Identities = 45/83 (54%), Positives = 62/83 (74%)

Query: 78  QAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEE 137
           +A+ E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK ++  EK+P+ EE
Sbjct: 627 RASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEE 686

Query: 138 AERLRVQHLRDHPNYKYRPRRKK 160
             RL   HL  +PNYKY+PR K+
Sbjct: 687 QARLSKIHLEKYPNYKYKPRPKR 709


>gi|224967050 SRY (sex determining region Y)-box 6 isoform 3 [Homo
           sapiens]
          Length = 801

 Score =  104 bits (259), Expect = 2e-22
 Identities = 45/83 (54%), Positives = 62/83 (74%)

Query: 78  QAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEE 137
           +A+ E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK ++  EK+P+ EE
Sbjct: 587 RASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEE 646

Query: 138 AERLRVQHLRDHPNYKYRPRRKK 160
             RL   HL  +PNYKY+PR K+
Sbjct: 647 QARLSKIHLEKYPNYKYKPRPKR 669


>gi|70909338 SRY (sex determining region Y)-box 6 isoform 1 [Homo
           sapiens]
          Length = 804

 Score =  104 bits (259), Expect = 2e-22
 Identities = 45/83 (54%), Positives = 62/83 (74%)

Query: 78  QAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEE 137
           +A+ E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK ++  EK+P+ EE
Sbjct: 590 RASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEE 649

Query: 138 AERLRVQHLRDHPNYKYRPRRKK 160
             RL   HL  +PNYKY+PR K+
Sbjct: 650 QARLSKIHLEKYPNYKYKPRPKR 672


>gi|71037389 SRY (sex determining region Y)-box 6 isoform 2 [Homo
           sapiens]
          Length = 808

 Score =  104 bits (259), Expect = 2e-22
 Identities = 45/83 (54%), Positives = 62/83 (74%)

Query: 78  QAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEE 137
           +A+ E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK ++  EK+P+ EE
Sbjct: 594 RASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEE 653

Query: 138 AERLRVQHLRDHPNYKYRPRRKK 160
             RL   HL  +PNYKY+PR K+
Sbjct: 654 QARLSKIHLEKYPNYKYKPRPKR 676


>gi|30061558 SRY (sex determining region Y)-box 5 isoform c [Homo
           sapiens]
          Length = 377

 Score =  103 bits (258), Expect = 2e-22
 Identities = 47/88 (53%), Positives = 64/88 (72%), Gaps = 4/88 (4%)

Query: 73  GRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKR 132
           GRG    ++E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK +   EK+
Sbjct: 162 GRG----SNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQ 217

Query: 133 PFVEEAERLRVQHLRDHPNYKYRPRRKK 160
           P+ EE  RL  QHL  +P+YKY+PR K+
Sbjct: 218 PYYEEQARLSKQHLEKYPDYKYKPRPKR 245


>gi|23308715 SRY (sex determining region Y)-box 5 isoform b [Homo
           sapiens]
          Length = 750

 Score =  103 bits (258), Expect = 2e-22
 Identities = 47/88 (53%), Positives = 64/88 (72%), Gaps = 4/88 (4%)

Query: 73  GRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKR 132
           GRG    ++E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK +   EK+
Sbjct: 535 GRG----SNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQ 590

Query: 133 PFVEEAERLRVQHLRDHPNYKYRPRRKK 160
           P+ EE  RL  QHL  +P+YKY+PR K+
Sbjct: 591 PYYEEQARLSKQHLEKYPDYKYKPRPKR 618


>gi|23308713 SRY (sex determining region Y)-box 5 isoform a [Homo
           sapiens]
          Length = 763

 Score =  103 bits (258), Expect = 2e-22
 Identities = 47/88 (53%), Positives = 64/88 (72%), Gaps = 4/88 (4%)

Query: 73  GRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKR 132
           GRG    ++E  I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK +   EK+
Sbjct: 548 GRG----SNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQ 603

Query: 133 PFVEEAERLRVQHLRDHPNYKYRPRRKK 160
           P+ EE  RL  QHL  +P+YKY+PR K+
Sbjct: 604 PYYEEQARLSKQHLEKYPDYKYKPRPKR 631


>gi|41406089 SRY-box 13 [Homo sapiens]
          Length = 622

 Score =  103 bits (258), Expect = 2e-22
 Identities = 44/83 (53%), Positives = 62/83 (74%)

Query: 78  QAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEE 137
           ++ + S I+RPMNAFMVWAKDER+++ Q  PD+HN+ +SK+LG  WK +   EK+P+ EE
Sbjct: 417 ESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEE 476

Query: 138 AERLRVQHLRDHPNYKYRPRRKK 160
             RL  QHL  +P+YKY+PR K+
Sbjct: 477 QARLSRQHLEKYPDYKYKPRPKR 499


>gi|4507225 sex determining region Y [Homo sapiens]
          Length = 204

 Score =  100 bits (249), Expect = 2e-21
 Identities = 41/78 (52%), Positives = 60/78 (76%)

Query: 82  ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERL 141
           + R++RPMNAF+VW++D+R+++A +NP + N+ +SK LG  WK L  AEK PF +EA++L
Sbjct: 57  QDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKL 116

Query: 142 RVQHLRDHPNYKYRPRRK 159
           +  H   +PNYKYRPRRK
Sbjct: 117 QAMHREKYPNYKYRPRRK 134


>gi|30581117 SRY (sex determining region Y)-box 30 isoform a [Homo
           sapiens]
          Length = 753

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 69/252 (27%), Positives = 109/252 (43%), Gaps = 26/252 (10%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           ++RPMNAFMVWA+  R  LA+ NP  +NA +S  LG  W +L+  +K+P+ +EA++++ +
Sbjct: 337 VKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEK 396

Query: 145 HLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLA-------PPQPPPEPFPAASGSARAF 197
           H  + P + Y+PR  K  RK   L    +  G         P    P   P  S    + 
Sbjct: 397 HREEFPGWVYQPRPGK--RKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSL 454

Query: 198 RE--LPPLGAEFDGLGLPTP---ERSPLDGLEPGEAA----FFPPPAAPEDCALRP--FR 246
           +     P+G     + LPTP     SP+   +P  ++        P+ P   AL P  F 
Sbjct: 455 QNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFT 514

Query: 247 APYAPT--ELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYP----GPLSPP 300
            P      +L  +       P   +L +A   +  A   +    T    P      +SP 
Sbjct: 515 GPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPC 574

Query: 301 PEAPPLESAEPL 312
           P + P+  A P+
Sbjct: 575 PRSAPIPQASPI 586


>gi|5902112 SRY (sex determining region Y)-box 30 isoform b [Homo
           sapiens]
          Length = 501

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 33/79 (41%), Positives = 54/79 (68%)

Query: 85  IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQ 144
           ++RPMNAFMVWA+  R  LA+ NP  +NA +S  LG  W +L+  +K+P+ +EA++++ +
Sbjct: 337 VKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEK 396

Query: 145 HLRDHPNYKYRPRRKKQAR 163
           H  + P + Y+PR  K+ R
Sbjct: 397 HREEFPGWVYQPRPGKRKR 415


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/124 (32%), Positives = 67/124 (54%), Gaps = 2/124 (1%)

Query: 51  PPSPQRSPPRSPEPGRYGLSPAGRGER-QAADESRIRRPMNAFMVWAKDERKRLAQQNPD 109
           PP  +R+   S  P     S    G      ++  IRRPMNAFM+++K  R  + Q++P+
Sbjct: 165 PPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPN 224

Query: 110 LHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKY-RPRRKKQARKARRL 168
             N  +SK+LG+ W  L   EK+ + + A +++  H + HP++K+    RKK + +A+  
Sbjct: 225 QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPT 284

Query: 169 EPGL 172
             GL
Sbjct: 285 SLGL 288



 Score = 32.3 bits (72), Expect = 0.74
 Identities = 26/89 (29%), Positives = 33/89 (37%), Gaps = 22/89 (24%)

Query: 6   PGYGAQDDPPARRDCAWAPGHGAAADTRGLAAG-------PAALAAPAA----------- 47
           PGYGA   P  +     APG G  A + G  AG       P  +  P A           
Sbjct: 768 PGYGAPAPPAVQFIAQGAPGGGTTAGS-GAGAGSGPNGPVPLGILQPGALGKAGGITQVQ 826

Query: 48  ---PASPPSPQRSPPRSPEPGRYGLSPAG 73
              P  P   Q +P  +P PG    +P+G
Sbjct: 827 YILPTLPQQLQVAPAPAPAPGTKAAAPSG 855



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 51/183 (27%), Positives = 66/183 (36%), Gaps = 44/183 (24%)

Query: 162  ARKARRLEPGLLLPGLAP-PQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPT------ 214
            A +A  L PG +  G++P P P   P  AA G        P + A + G   PT      
Sbjct: 1059 AGQAPLLAPGQV--GVSPVPSPQLPPACAAPGG-------PVITAFYSGSPAPTSSAPLA 1109

Query: 215  -PERSPLDGLEPGEAAFFPPPAA-------PEDCALRPFRAPYAPTELSRDPGGCYGAPL 266
             P ++P   L    A    PPAA       P      P  AP +P   +      Y    
Sbjct: 1110 QPSQAP-PSLVYTVATSTTPPAATILPKGPPAPATATP--APTSPFPSATAGSMTYSLVA 1166

Query: 267  AEALRTAPPAA----------PLAGLYYGTLGTPGPYP-GPLSPPPEAPPLESAEPLGPA 315
             +A R +P A           P+     G  G PGP P  PL P P        EP  P 
Sbjct: 1167 PKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGP------VREPTAPE 1220

Query: 316  ADL 318
            ++L
Sbjct: 1221 SEL 1223



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 35/124 (28%), Positives = 44/124 (35%), Gaps = 8/124 (6%)

Query: 191  SGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYA 250
            S  A  F  L P G  F    L +  ++PL  L PG+    P P+     A      P  
Sbjct: 1036 SSVALGFTSLGPSGPAFVQ-PLLSAGQAPL--LAPGQVGVSPVPSPQLPPACAAPGGPVI 1092

Query: 251  PTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAE 310
                S  P     APLA+     P  AP + +Y     T  P    L   P AP   +  
Sbjct: 1093 TAFYSGSPAPTSSAPLAQ-----PSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPA 1147

Query: 311  PLGP 314
            P  P
Sbjct: 1148 PTSP 1151


>gi|198442849 transcription factor 7 (T-cell specific, HMG-box) 5
           [Homo sapiens]
          Length = 366

 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 71/273 (26%), Positives = 109/273 (39%), Gaps = 52/273 (19%)

Query: 45  PAAPASPPSPQRSPPRSPEPGRYGLSPAGRG-----ERQAADESR---IRRPMNAFMVWA 96
           P  PA+ P P   PP     G+  L P  R      E +A  E++   I++P+NAFM++ 
Sbjct: 110 PGHPAAIPHPAIVPPS----GKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYM 165

Query: 97  KDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRP 156
           K+ R ++  +     +A ++++LG+ W  L+  E+  + E A + R  H++ +P +  R 
Sbjct: 166 KEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARD 225

Query: 157 RRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLG----- 211
              K+ R++R              +   +P     GS +  R    L  + D  G     
Sbjct: 226 NYGKKKRRSREKH----------QESTTDP-----GSPKKCRARFGLNQQTDWCGPCRRK 270

Query: 212 ------LPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAP 265
                 LP   R P        A   P   AP+D        P  PTEL   P     AP
Sbjct: 271 KKCIRYLPGEGRCPSPVPSDDSALGCPGSPAPQDSPSYHL-LPRFPTELLTSP--AEPAP 327

Query: 266 LAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLS 298
            +  L TA            +L TPGP   P S
Sbjct: 328 TSPGLSTAL-----------SLPTPGPPQAPRS 349


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 77/297 (25%), Positives = 112/297 (37%), Gaps = 76/297 (25%)

Query: 53   SPQRSPPRSPEPGRYGLSPA--------GRGERQAADESRIRRPMNAFMVWAKDER---- 100
            SP+   P SP  G  G +P+        G G+  + ++  ++R       W KDE     
Sbjct: 1963 SPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQR-------WEKDEELGQL 2015

Query: 101  -------------KRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLR 147
                           L Q  PD  +    K + K W+++ AA+K P++++A+  R  H  
Sbjct: 2016 STISPVLYANINFPNLKQDYPDWSSRC--KQIMKLWRKVPAADKAPYLQKAKDNRAAHRI 2073

Query: 148  DHPNYKYRPRRKKQ------ARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELP 201
            +    +   +  KQ      ARK  R    L +P          P P A GS       P
Sbjct: 2074 NKVQKQAESQINKQTKVGDIARKTDRPALHLRIP----------PQPGALGSP------P 2117

Query: 202  PLGAEFDGLGLPTPE---RSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTEL-SRD 257
            P  A    +G PT      +  DG     A   P P +P +  L+    P  P ++ S+D
Sbjct: 2118 PAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLK--LPPQVPAQVPSQD 2175

Query: 258  PGGCYGA-PLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLG 313
            P G   A PL     TAPP  P             PYP P   P + P L ++   G
Sbjct: 2176 PFGLAPAYPLEPRFPTAPPTYP-------------PYPSPTGAPAQPPMLGASSRPG 2219



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 58/169 (34%), Positives = 73/169 (43%), Gaps = 20/169 (11%)

Query: 164 KARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGL 223
           +A RL P    P  +P  PPPE  P  S    A R  PP   E   L  P PE SPL   
Sbjct: 568 EASRLSPP---PEESPMSPPPEESPM-SPPPEASRLFPPF--EESPLS-PPPEESPLS-- 618

Query: 224 EPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPA--APLAG 281
            P EA+   PP  PED  + P   P   + +S  P     +PL    R +PP   +PL+ 
Sbjct: 619 PPPEASRLSPP--PEDSPMSP---PPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSP 673

Query: 282 LYYGTLGTPGPYPGPLSPPPE----APPLESAEPLGPAADLWADVDLTE 326
               +  +P P    LSPPPE    +PP E +    P  D    + L E
Sbjct: 674 PPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEE 722



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 56/159 (35%), Positives = 71/159 (44%), Gaps = 31/159 (19%)

Query: 174 LPGLAPPQ-----PPPE-----PFPAASGSARAFRELP--PLGAEFDGLGLPTP-ERSPL 220
           +P L PP+     PPPE     P P AS  +    ELP  PL    + L L  P E SPL
Sbjct: 438 MPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP---EALHLSRPLEESPL 494

Query: 221 DGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLA 280
               P E+   PPP +     L    +P +P E S  P      PL+      P A+PL+
Sbjct: 495 SP-PPEESPLSPPPESSPFSPLE--ESPLSPPEES-PPSPALETPLSPP----PEASPLS 546

Query: 281 GLYYGTLGTPGPYPGPLSPPPEA-----PPLESAEPLGP 314
             +  +  +P P   P SPPPEA     PP ES  P+ P
Sbjct: 547 PPFEESPLSPPPEELPTSPPPEASRLSPPPEES--PMSP 583



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 11/133 (8%)

Query: 177 LAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGL-PTPERSPLDGLEPGEAAFFPPPA 235
           L+PP+  P P PA         E  PL   F+   L P PE  P     P EA+   PP 
Sbjct: 520 LSPPEESP-PSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTS--PPPEASRLSPPP 576

Query: 236 APEDCALRPFRAPYAPT-ELSRDPGGCYGAPLAEALRTAPPA-APLAGLYYGTLGTPGPY 293
                +  P  +P +P  E SR        P  E+  + PP  +PL+     +  +P P 
Sbjct: 577 EESPMSPPPEESPMSPPPEASR-----LFPPFEESPLSPPPEESPLSPPPEASRLSPPPE 631

Query: 294 PGPLSPPPEAPPL 306
             P+SPPPE  P+
Sbjct: 632 DSPMSPPPEESPM 644



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 59/215 (27%), Positives = 75/215 (34%), Gaps = 15/215 (6%)

Query: 175  PGLAPPQPPPEPFPAASG---SARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFF 231
            P L+P   PP+P P       +A A   L PLG     L  P   +   D   P  A   
Sbjct: 923  PSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGE----LEYPFGAKGDSDPESPLAAPIL 978

Query: 232  PPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPP-AAPLAGLYYGTLGTP 290
              P +P   A      P  P  L   PG   G      +   PP  +PL  L +  +   
Sbjct: 979  ETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPL--LQHSLVPQN 1036

Query: 291  GPYPGPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALA 350
             P P   SPP  A PL    PL P   +    D  E  +      + P+ P L       
Sbjct: 1037 SP-PSQCSPP--ALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSP 1093

Query: 351  KLGPRA-MSCPEESSLISALSDASSAVYYSACISG 384
               P   +SCP  S    AL D S     +A + G
Sbjct: 1094 LPSPMGDLSCPAPSP-APALDDFSGLGEDTAPLDG 1127



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 43/129 (33%), Positives = 50/129 (38%), Gaps = 28/129 (21%)

Query: 199 ELPPLGAEFDGLGLPTPERSPLDGLE---PGEAAFFPPPAAPEDCALRPFRAPYAPTELS 255
           E PPL         P PE+ P +  +   P E   FPPP  P   +L P     A +E  
Sbjct: 856 EKPPLS--------PRPEKPPEEPGQCPAPEELPLFPPPGEP---SLSPLLGEPALSE-- 902

Query: 256 RDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSP------PPEAPPLESA 309
             PG    +PL E L  +P   P        L  P P P PLSP      PP   PL   
Sbjct: 903 --PGEPPLSPLPEELPLSPSGEPSLS---PQLMPPDPLPPPLSPIITAAAPPALSPLGEL 957

Query: 310 E-PLGPAAD 317
           E P G   D
Sbjct: 958 EYPFGAKGD 966



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 65/285 (22%), Positives = 93/285 (32%), Gaps = 93/285 (32%)

Query: 39   PAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKD 98
            P+   APA P  P     S P + +PG +  +P G    Q +      +P          
Sbjct: 2200 PSPTGAPAQP--PMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKP---------- 2247

Query: 99   ERKRLAQQNPDLHNAVLSKMLG----KAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKY 154
                   + P L N  + +  G    KA + L +    PF E  + L V           
Sbjct: 2248 -------RCPSLDNLAVPESPGVGGGKASEPLLSPP--PFGESRKALEV----------- 2287

Query: 155  RPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPT 214
                       ++ E G   P   PP                F + P  G    GL L T
Sbjct: 2288 -----------KKEELGASSPSYGPPN-------------LGFVDSPSSGTHLGGLELKT 2323

Query: 215  PERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAP 274
            P+              F  P  P    + P ++P       ++P      P A+AL  +P
Sbjct: 2324 PD-------------VFKAPLTPRASQVEP-QSPGLGLR-PQEP------PPAQALAPSP 2362

Query: 275  PAAPLAGLYYGTLGTPGPYPGP-----LSPPPEAPPLESAEPLGP 314
            P+ P        +  PG Y  P     L+P P+ PP ES   L P
Sbjct: 2363 PSHP-------DIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPP 2400



 Score = 32.3 bits (72), Expect = 0.74
 Identities = 61/243 (25%), Positives = 80/243 (32%), Gaps = 68/243 (27%)

Query: 181 QPPPEPFPAASGSARAFR----------ELPPLGAEFDGLGL------------------ 212
           +PP E  PA S   +A R          EL P    F+   L                  
Sbjct: 304 KPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAQGGQTIRSVAE 363

Query: 213 -PTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGG--CYGAPLAEA 269
             TP  S     EPG+     P A    C  +P +  +  +   ++PG   C   PL +A
Sbjct: 364 QHTPVCSRFSPPEPGDTPTDEPDALYVACQGQP-KGGHVTSMQPKEPGPLQCEAKPLGKA 422

Query: 270 -----------------LRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEA----PPLES 308
                            L   P  +PL+         P P   P SPPPEA    PP E 
Sbjct: 423 GVQLEPQLEAPLNEEMPLLPPPEESPLS---------PPPEESPTSPPPEASRLSPPPEE 473

Query: 309 --AEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLI 366
             A PL  A  L   ++ +        S   P     P+    + L    +S PEES   
Sbjct: 474 LPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPF----SPLEESPLSPPEESPPS 529

Query: 367 SAL 369
            AL
Sbjct: 530 PAL 532



 Score = 32.3 bits (72), Expect = 0.74
 Identities = 80/306 (26%), Positives = 104/306 (33%), Gaps = 56/306 (18%)

Query: 47  APASPPSPQRSPPRSPEPGRYGLSPAGRGERQAA--DESRIRRPMNAFMVWAKDERKRLA 104
           +P SPP P+ SP  SP P    LSP     R +   +ES +  P          E  RL+
Sbjct: 633 SPMSPP-PEESP-MSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLS 690

Query: 105 QQ------NPDLHNAVLSKMLGKAWKELNAAEKR--PFVEEAE---RLRVQHLRDHPNYK 153
                   +P   ++  S     +   L   E    P  EE +   R    HL   P   
Sbjct: 691 PPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEP 750

Query: 154 YRPRRKKQARKARRLEPGLLLPGLAPPQP-----PPEPF--PAASGSARAFRELPPLGAE 206
           +   R ++   + + E   L P   P +P     P EP   P A G        P L  +
Sbjct: 751 HLSPRPEEPHLSPQAEEPHLSP--QPEEPCLCAVPEEPHLSPQAEG--------PHLSPQ 800

Query: 207 FDGLGLPTPERSPLDGLEPGEAAFFPPPAA---------------PEDCALRPF--RAPY 249
            + L L      P     P E    P P                 PE+  L P   + P 
Sbjct: 801 PEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPL 860

Query: 250 APT--ELSRDPGGCYGAPLAEALRT-APPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPL 306
           +P   +   +PG C   P  E L    PP  P      G      P   PLSP PE  PL
Sbjct: 861 SPRPEKPPEEPGQC---PAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPL 917

Query: 307 E-SAEP 311
             S EP
Sbjct: 918 SPSGEP 923



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 43/166 (25%), Positives = 57/166 (34%), Gaps = 25/166 (15%)

Query: 146  LRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPP-PEPFPAASGSARAFRELPPLG 204
            L  +P  ++   +++Q  +A  ++  L         PP  EP    S         P LG
Sbjct: 4205 LAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLG 4264

Query: 205  AEFDGLGLPTPERSPLDGLEPGEAAFFPP--PAAPEDCALRPFRAPYAPTELSRDPG--- 259
                  G P P+  PL  L  G     PP  PA P   +  P   P  PT     P    
Sbjct: 4265 ------GFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPK 4318

Query: 260  --GCYGAPLAEALRTA--PPAAPLAGLYYGTLGTPGPYPGPLSPPP 301
                  +P ++    A  PP  P         GTP P    L PPP
Sbjct: 4319 RPSQLPSPSSQLPTEAQLPPTHP---------GTPKPQGPTLEPPP 4355


>gi|217035121 HMG-BOX transcription factor BBX isoform 1 [Homo
           sapiens]
          Length = 941

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 29/91 (31%), Positives = 49/91 (53%)

Query: 73  GRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKR 132
           G  E   + E R RRPMNAF+++ K  R  + Q++P L N   +K+L   W  L+  EK+
Sbjct: 68  GETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQ 127

Query: 133 PFVEEAERLRVQHLRDHPNYKYRPRRKKQAR 163
            + + A+  +   ++ +P YK+ P   K  +
Sbjct: 128 KYTDMAKEYKDAFMKANPGYKWCPTTNKPVK 158


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.135    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,417,965
Number of Sequences: 37866
Number of extensions: 1575391
Number of successful extensions: 21927
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 1090
Number of HSP's that attempted gapping in prelim test: 13040
Number of HSP's gapped (non-prelim): 8376
length of query: 384
length of database: 18,247,518
effective HSP length: 104
effective length of query: 280
effective length of database: 14,309,454
effective search space: 4006647120
effective search space used: 4006647120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.