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Search of human proteins with 7706657
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706657 cell division cycle 40 homolog [Homo sapiens]
(579 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 1198 0.0
gi|241896935 WD repeat domain 25 [Homo sapiens] 149 9e-36
gi|241896933 WD repeat domain 25 [Homo sapiens] 149 9e-36
gi|16554629 WD repeat domain 5 [Homo sapiens] 132 7e-31
gi|16554627 WD repeat domain 5 [Homo sapiens] 132 7e-31
gi|23199987 WD repeat domain 5B [Homo sapiens] 126 6e-29
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 108 1e-23
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 91 3e-18
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 89 8e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 87 5e-17
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 86 9e-17
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 86 9e-17
gi|32189425 WD repeat domain 69 [Homo sapiens] 84 3e-16
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 84 4e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 84 4e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 84 4e-16
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 84 4e-16
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 84 4e-16
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 84 4e-16
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 84 5e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 83 8e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 83 8e-16
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 82 1e-15
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 82 2e-15
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 82 2e-15
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 81 2e-15
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 81 2e-15
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 79 9e-15
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 79 9e-15
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 79 9e-15
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 1198 bits (3099), Expect = 0.0
Identities = 579/579 (100%), Positives = 579/579 (100%)
Query: 1 MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV 60
MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV
Sbjct: 1 MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV 60
Query: 61 AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI 120
AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
Sbjct: 61 AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI 120
Query: 121 NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK 180
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK
Sbjct: 121 NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK 180
Query: 181 FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI 240
FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI
Sbjct: 181 FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI 240
Query: 241 LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS 300
LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS
Sbjct: 241 LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS 300
Query: 301 GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD
Sbjct: 301 GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Query: 361 TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA 420
TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
Sbjct: 361 TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA 420
Query: 421 VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS 480
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS
Sbjct: 421 VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS 480
Query: 481 MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT 540
MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT
Sbjct: 481 MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT 540
Query: 541 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
Sbjct: 541 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
>gi|241896935 WD repeat domain 25 [Homo sapiens]
Length = 544
Score = 149 bits (375), Expect = 9e-36
Identities = 83/313 (26%), Positives = 159/313 (50%), Gaps = 13/313 (4%)
Query: 276 LPKKQIHVWSGHTKGVSAVRLFPL--SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK 333
+P+K + GH V+ ++ P+ H+LLS SMD K+W CL+T+ H++
Sbjct: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293
Query: 334 AVRDICFNTAGTQFLSAAYDRYLKLWDTETG-QCISRFTNRKVPYCVKFNPDEDKQNLFV 392
AVR + G + LS +D L L D ETG Q S ++ ++ +KF+P + N+F+
Sbjct: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT-TLKFHPKD--HNIFL 350
Query: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD-------DKSLRVW 445
G ++ WDIR+G++++ Y + I+F+ E F+S++D D+++ W
Sbjct: 351 CGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAW 410
Query: 446 EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
++ + P++ L P Q+ N + +F +R+++++ ++GH
Sbjct: 411 DFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGH 470
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565
V GY+ + SP +++G +G++ ++ ++T + H + C+G +HP S
Sbjct: 471 KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV 530
Query: 566 VITCGWDGLIKLW 578
+ TC W G +K+W
Sbjct: 531 LATCSWGGDMKIW 543
>gi|241896933 WD repeat domain 25 [Homo sapiens]
Length = 544
Score = 149 bits (375), Expect = 9e-36
Identities = 83/313 (26%), Positives = 159/313 (50%), Gaps = 13/313 (4%)
Query: 276 LPKKQIHVWSGHTKGVSAVRLFPL--SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK 333
+P+K + GH V+ ++ P+ H+LLS SMD K+W CL+T+ H++
Sbjct: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293
Query: 334 AVRDICFNTAGTQFLSAAYDRYLKLWDTETG-QCISRFTNRKVPYCVKFNPDEDKQNLFV 392
AVR + G + LS +D L L D ETG Q S ++ ++ +KF+P + N+F+
Sbjct: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT-TLKFHPKD--HNIFL 350
Query: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD-------DKSLRVW 445
G ++ WDIR+G++++ Y + I+F+ E F+S++D D+++ W
Sbjct: 351 CGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAW 410
Query: 446 EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
++ + P++ L P Q+ N + +F +R+++++ ++GH
Sbjct: 411 DFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGH 470
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565
V GY+ + SP +++G +G++ ++ ++T + H + C+G +HP S
Sbjct: 471 KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV 530
Query: 566 VITCGWDGLIKLW 578
+ TC W G +K+W
Sbjct: 531 LATCSWGGDMKIW 543
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 132 bits (333), Expect = 7e-31
Identities = 84/299 (28%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
+GHTK VS+V+ P +G L S S D IK+W Y + + +T GH + D+ +++
Sbjct: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99
Query: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403
+SA+ D+ LK+WD +G+C+ +C FNP + NL V+G D+ + W
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156
Query: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463
D+++G+ ++ H V+ + F + VS+S D R+W+ K + +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 464 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 522
+ V SPNGK++ ++DN + ++ L K + GH Y +FS +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273
Query: 523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578
++SG + + IW+ +T ++ + + H V I HP T +I D IKLW
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--TENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 132 bits (333), Expect = 7e-31
Identities = 84/299 (28%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
+GHTK VS+V+ P +G L S S D IK+W Y + + +T GH + D+ +++
Sbjct: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99
Query: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403
+SA+ D+ LK+WD +G+C+ +C FNP + NL V+G D+ + W
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156
Query: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463
D+++G+ ++ H V+ + F + VS+S D R+W+ K + +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 464 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 522
+ V SPNGK++ ++DN + ++ L K + GH Y +FS +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273
Query: 523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578
++SG + + IW+ +T ++ + + H V I HP T +I D IKLW
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--TENIIASAALENDKTIKLW 330
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 126 bits (316), Expect = 6e-29
Identities = 82/298 (27%), Positives = 145/298 (48%), Gaps = 15/298 (5%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GHT+ VS+V+ P +G L S S D I +W Y + + +T GH+ + D+ +++ +
Sbjct: 39 GHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404
+ +SA+ D+ LKLWD +G+C+ +C FNP NL ++G D+ + W+
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS---NLIISGSFDETVKIWE 153
Query: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSM 464
+++G+ ++ H V+ + F VS S D R+W+ K + + +
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 465 PAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSYV 523
V SPNGK++ ++DN + ++ + R K + GH Y +FS ++
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLW---DYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 524 ISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578
+SG + + IW+ +T ++ + + H V I A HP T +I D IKLW
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP--TENLIASAALENDKTIKLW 326
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 108 bits (271), Expect = 1e-23
Identities = 78/296 (26%), Positives = 132/296 (44%), Gaps = 9/296 (3%)
Query: 271 PEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIG 330
P +C + I + SGH V + P +G L S D I LW VYG+ T G
Sbjct: 49 PPRCSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDCDNYATLKG 107
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNL 390
HS AV ++ +NT G+ SA+ D+ + +WD+ETG+ + R + P L
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH-TSFVNSCYPARRGPQL 166
Query: 391 FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 450
G D + WDIR +Q + ++ V + F D + + +S D ++VW+
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR-Q 224
Query: 451 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKK--KIFKG--HM 506
Y S+ ++LS G +L +MDN + ++ + F ++ KIF+G H
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR-PFAPKERCVKIFQGNVHN 283
Query: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHE 562
+ +SPD S + +G + + +WD + ++ + H +HP E
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
Score = 59.3 bits (142), Expect = 9e-09
Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 13/152 (8%)
Query: 304 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363
++S +D IK+W++ + + T GH+ +V + ++ G+ LS A D +++WD
Sbjct: 208 IISGGIDNDIKVWDLR-QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
Query: 364 ----GQCISRFTNR-----KVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEY 414
+C+ F K ++PD K AG +D+ + WD S I+ +
Sbjct: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK---IAAGSADRFVYVWDTTSRRILYKL 323
Query: 415 DRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
H G++N + F + +S S DK L + E
Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 4/109 (3%)
Query: 471 PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNG 530
PNG LA D IL++ + KGH +G ++ ++ D S + S +
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGD--CDNYATLKGH--SGAVMELHYNTDGSMLFSASTDK 131
Query: 531 KLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
+ +WD +T + R K H V T DG +KLWD
Sbjct: 132 TVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 90.9 bits (224), Expect = 3e-18
Identities = 72/264 (27%), Positives = 117/264 (44%), Gaps = 20/264 (7%)
Query: 277 PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLW--EVYGERRCLRTFIGHSKA 334
P+ + + ++GH V+ V P SGHLL S S D +++W V GE R H+
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIWVPNVKGESTVFR---AHTAT 67
Query: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFVA 393
VR + F + G F++A+ D+ +K+W T + + + C KF+PD L V+
Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD---GRLIVS 124
Query: 394 GMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDF 453
DK + WD S E V Y H G V + F + D +++VW+
Sbjct: 125 ASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD---VRTH 181
Query: 454 KYIAEPSMHSMPAVTLS--PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYA 511
+ + +HS LS P+G +L S D+ + I + + ++ H G A
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL-----MEGRLLYTLHGHQGPA 236
Query: 512 CQVDFSPDMSYVISGDGNGKLNIW 535
V FS Y SG + ++ +W
Sbjct: 237 TTVAFSRTGEYFASGGSDEQVMVW 260
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/232 (24%), Positives = 103/232 (44%), Gaps = 19/232 (8%)
Query: 353 DRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQW--DIRSGE 409
D L +W + RFT K CV F+P +L +G DK + W +++
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG---HLLASGSRDKTVRIWVPNVKGES 58
Query: 410 IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS--MPAV 467
V + H V ++ F + + FV+ SDDK+++VW K++ S H +
Sbjct: 59 TV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ---KFLFSLSQHINWVRCA 113
Query: 468 TLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGD 527
SP+G+ + S D + ++ +R ++ + H G+ VDF P + + +
Sbjct: 114 KFSPDGRLIVSASDDKTVKLWDKSSRECVHS---YCEH--GGFVTYVDFHPSGTCIAAAG 168
Query: 528 GNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
+ + +WD +T +L ++ H G +HP + +IT D +K+ D
Sbjct: 169 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 219
Score = 67.4 bits (163), Expect = 3e-11
Identities = 53/228 (23%), Positives = 97/228 (42%), Gaps = 26/228 (11%)
Query: 279 KQIHVWSGH--------TKGVSAVRL--FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 328
K + VW+ H ++ ++ VR F G L++S S D +KLW+ R C+ ++
Sbjct: 87 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSY 145
Query: 329 IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDK 387
H V + F+ +GT +A D +K+WD T + + + + F+P
Sbjct: 146 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-- 203
Query: 388 QNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW 447
N + SD + D+ G ++ H G T+ F F S D+ + VW+
Sbjct: 204 -NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262
Query: 448 DIPV----DFKYIAEP------SMHSMPAVTLS-PNGKWLACQSMDNQ 484
+ + + + P SM ++P V P G+ + +S+ +Q
Sbjct: 263 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQ 310
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/253 (23%), Positives = 102/253 (40%), Gaps = 33/253 (13%)
Query: 309 MDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCIS 368
MD + +W + + R R F GH AV + F+ +G S + D+ +++W +
Sbjct: 1 MDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
Query: 369 RF-----TNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 423
F T R V +C D Q+ FV DK + W + + +H+ V
Sbjct: 60 VFRAHTATVRSVHFC------SDGQS-FVTASDDKTVKVWATHRQKFLFSLSQHINWVRC 112
Query: 424 IVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS-------MPAVTLSPNGKWL 476
F + R VS SDDK++++W+ + +HS + V P+G +
Sbjct: 113 AKFSPDGRLIVSASDDKTVKLWDKS--------SRECVHSYCEHGGFVTYVDFHPSGTCI 164
Query: 477 ACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
A MDN + ++ + L ++ H A + F P +Y+I+ + L I D
Sbjct: 165 AAAGMDNTVKVWDVRTHRLLQHYQL---HSAA--VNGLSFHPSGNYLITASSDSTLKILD 219
Query: 537 WKTTKLYSRFKAH 549
+L H
Sbjct: 220 LMEGRLLYTLHGH 232
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 89.4 bits (220), Expect = 8e-18
Identities = 68/292 (23%), Positives = 133/292 (45%), Gaps = 24/292 (8%)
Query: 213 QKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNL------- 265
Q + +T +R+K+GK E+ + + + +++ + G IP + ++L
Sbjct: 177 QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNK 236
Query: 266 -------RSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV 318
++ + +K ++ + GHTK V++V P S L+ S S D I++W V
Sbjct: 237 ILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV 293
Query: 319 YGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY- 377
C++ H AV + + G LS++ D+Y D +TG+ +++ T+
Sbjct: 294 -PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
Query: 378 --CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVS 435
C +F+PD +F G D +I WD++ V + H G + +I F + +
Sbjct: 353 LTCAQFHPDG---LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
Query: 436 TSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILI 487
+DD S+++W+ +FK + + + ++ +G +LA D QI I
Sbjct: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461
Score = 46.2 bits (108), Expect = 8e-05
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 7/192 (3%)
Query: 389 NLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
N + G +DK +V +D S +I+ H V ++VF S S D ++R+W
Sbjct: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS-- 292
Query: 449 IP-VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMV 507
+P + ++ ++L G +L S D+Q F R+ K+
Sbjct: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSS-DDQYWAFSDIQTGRV-LTKVTDETSG 350
Query: 508 AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVI 567
C F PD +G + ++ IWD K + F H I ++ +
Sbjct: 351 CSLTC-AQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP-ITSIAFSENGYYLA 408
Query: 568 TCGWDGLIKLWD 579
T D +KLWD
Sbjct: 409 TAADDSSVKLWD 420
Score = 30.4 bits (67), Expect = 4.7
Identities = 15/66 (22%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 514 VDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWD 572
+D P D + +++G + + ++D + ++ + K H K V+HP + V + D
Sbjct: 227 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPD 285
Query: 573 GLIKLW 578
I++W
Sbjct: 286 ATIRIW 291
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 86.7 bits (213), Expect = 5e-17
Identities = 65/255 (25%), Positives = 112/255 (43%), Gaps = 11/255 (4%)
Query: 326 RTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPD 384
R F GH A+ + + G Q +A++D +L LW+ + R+ K V V+F+P
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 385 EDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRV 444
NL + D+ + W E+ H V ++ F + + + S+DKS++V
Sbjct: 72 G---NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 445 WEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKG 504
W F Y H + SP+G+ + S D I I+ N+ +N F
Sbjct: 129 WSM-YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN---FSD 184
Query: 505 HMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS 564
+ G+A VDF+P + + S + + +WD + KL ++ H +HP +
Sbjct: 185 SV--GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP-SGN 241
Query: 565 KVITCGWDGLIKLWD 579
+IT DG +K+ D
Sbjct: 242 YLITASSDGTLKILD 256
Score = 85.9 bits (211), Expect = 9e-17
Identities = 62/222 (27%), Positives = 107/222 (48%), Gaps = 15/222 (6%)
Query: 273 KCYLPKKQ--IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIG 330
+ ++P K+ + HT V +V F G L + S D IK+W +Y +R L +
Sbjct: 85 RLWIPDKRGKFSEFKAHTAPVRSVD-FSADGQFLATASEDKSIKVWSMY-RQRFLYSLYR 142
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC--VKFNPDEDKQ 388
H+ VR F+ G +S + D+ +K+WDT QC++ F++ V + V FNP
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD-SVGFANFVDFNPSG--- 198
Query: 389 NLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
+ SD+ + WD+R +++Q Y H G VN I F ++ S D +L++ +
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL- 257
Query: 449 IPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIF 488
++ + I H+ P V+ S G+ A D Q+L++
Sbjct: 258 --LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 79.0 bits (193), Expect = 1e-14
Identities = 67/268 (25%), Positives = 113/268 (42%), Gaps = 14/268 (5%)
Query: 284 WSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA 343
+ GH ++++ L P +G L + S D + LW R R ++GH V + F+
Sbjct: 14 FKGHKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYR-YVGHKDVVTSVQFSPH 71
Query: 344 GTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVAGMS-DKKIV 401
G SA+ DR ++LW + S F P V F+ D F+A S DK I
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ----FLATASEDKSIK 127
Query: 402 QWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSM 461
W + + RH V F + R VS S+DK++++W+ ++ S+
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD-SV 186
Query: 462 HSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMS 521
V +P+G +A D + ++ + L ++ G G C + F P +
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG----GVNC-ISFHPSGN 241
Query: 522 YVISGDGNGKLNIWDWKTTKLYSRFKAH 549
Y+I+ +G L I D +L + H
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGH 269
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
K + + H+ GV+ + P SG+ L++ S D +K+ ++ E R + T GH+ V +
Sbjct: 219 KLLQHYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLL-EGRLIYTLQGHTGPVFTV 276
Query: 339 CFNTAGTQFLSAAYDRYLKLWDT 361
F+ G F S D + LW T
Sbjct: 277 SFSKGGELFASGGADTQVLLWRT 299
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 85.9 bits (211), Expect = 9e-17
Identities = 78/325 (24%), Positives = 139/325 (42%), Gaps = 54/325 (16%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSC-SMDCKIKLWEVYGERRCLRTFIGHSKAVRDIC 339
+H + H++ V+ S HLLL+ S DC +KLW++ ++ C T GH+ +V
Sbjct: 692 VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCR 750
Query: 340 FNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLF-------- 391
F+ S + D LKLWD T + N K + +P ED + +
Sbjct: 751 FSPDDKLLASCSADGTLKLWDA-TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 392 ---VAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
+ + KI W+ S V + HL V+ ++F + F+++SDD+++R+WE
Sbjct: 810 GARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-- 867
Query: 449 IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVA 508
K + + S AV L + +N++++ + RL ++
Sbjct: 868 ----TKKVCKNS-----AVMLKQE---VDVVFQENEVMVLAVDHIRRL--------QLIN 907
Query: 509 GYACQVDF-----------SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAV 557
G Q+D+ SP + Y+ GD NG + I + +++ H K V
Sbjct: 908 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK----TV 963
Query: 558 WHPHETS---KVITCGWDGLIKLWD 579
WH T+ +I+ D I++W+
Sbjct: 964 WHIQFTADEKTLISSSDDAEIQVWN 988
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 33/268 (12%)
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF-TNRKVPYCVKFNPDEDKQN 389
H+ AV CF+ G + S D+ L+++ ETG+ + + C F+ D+
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR--- 670
Query: 390 LFVAGMS-DKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV--STSDDKSLRVWE 446
F+A S DKK+ W+ +GE+V YD H VN F + + + + S D L++W+
Sbjct: 671 -FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 447 WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIF---GAQNRFRLNKKKIFK 503
+ + + +S+ SP+ K LA S D + ++ A R +N K+ F
Sbjct: 730 LN-QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFL 788
Query: 504 GHMVAGYACQVDFSPDMSYVI-----SGDG-------NGKLNIWDWKTTKLYSRFKAHDK 551
D DM ++ S DG K+ +W+ + + + H
Sbjct: 789 N--------LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840
Query: 552 VCIGAVWHPHETSKVITCGWDGLIKLWD 579
G ++ P + S +T D I+LW+
Sbjct: 841 WVHGVMFSP-DGSSFLTSSDDQTIRLWE 867
Score = 55.8 bits (133), Expect = 1e-07
Identities = 68/294 (23%), Positives = 116/294 (39%), Gaps = 18/294 (6%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GH V V P G L+ S D I+LWE ++ C + + + V D+ F
Sbjct: 837 GHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWET--KKVCKNSAVMLKQEV-DVVFQENEV 892
Query: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDI 405
L+ + R L+L + TGQ I T +V C G + I ++
Sbjct: 893 MVLAVDHIRRLQLINGRTGQ-IDYLTEAQVSCCCL----SPHLQYIAFGDENGAIEILEL 947
Query: 406 RSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP 465
+ I Q +H V I F + + +S+SDD ++VW W + D ++
Sbjct: 948 VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVK 1005
Query: 466 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVIS 525
L N + L+ S D + ++ N NK+K F H +C D S D + S
Sbjct: 1006 DFRLLKNSRLLS-WSFDGTVKVW---NIITGNKEKDFVCHQGTVLSC--DISHDATKFSS 1059
Query: 526 GDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
+ IW + + H+ C+ +++ + T +G I++W+
Sbjct: 1060 TSADKTAKIWSFDLLLPLHELRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWN 1112
Score = 43.9 bits (102), Expect = 4e-04
Identities = 43/209 (20%), Positives = 87/209 (41%), Gaps = 8/209 (3%)
Query: 323 RCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFN 382
R ++ H K V I F +S++ D +++W+ + +CI +++ +
Sbjct: 951 RIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLL 1010
Query: 383 PDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSL 442
K + ++ D + W+I +G +++ H G V + + +F STS DK+
Sbjct: 1011 ----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1066
Query: 443 RVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIF 502
++W +D+ + + + + S + LA + +I I+ N L+
Sbjct: 1067 KIWSFDLLLPLHELRGHN-GCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1125
Query: 503 KGHMVA---GYACQVDFSPDMSYVISGDG 528
A G+ + FSPD +IS G
Sbjct: 1126 SEEGAATHGGWVTDLCFSPDGKMLISAGG 1154
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 85.9 bits (211), Expect = 9e-17
Identities = 78/325 (24%), Positives = 139/325 (42%), Gaps = 54/325 (16%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSC-SMDCKIKLWEVYGERRCLRTFIGHSKAVRDIC 339
+H + H++ V+ S HLLL+ S DC +KLW++ ++ C T GH+ +V
Sbjct: 681 VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCR 739
Query: 340 FNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLF-------- 391
F+ S + D LKLWD T + N K + +P ED + +
Sbjct: 740 FSPDDKLLASCSADGTLKLWDA-TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
Query: 392 ---VAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
+ + KI W+ S V + HL V+ ++F + F+++SDD+++R+WE
Sbjct: 799 GARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-- 856
Query: 449 IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVA 508
K + + S AV L + +N++++ + RL ++
Sbjct: 857 ----TKKVCKNS-----AVMLKQE---VDVVFQENEVMVLAVDHIRRL--------QLIN 896
Query: 509 GYACQVDF-----------SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAV 557
G Q+D+ SP + Y+ GD NG + I + +++ H K V
Sbjct: 897 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK----TV 952
Query: 558 WHPHETS---KVITCGWDGLIKLWD 579
WH T+ +I+ D I++W+
Sbjct: 953 WHIQFTADEKTLISSSDDAEIQVWN 977
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 33/268 (12%)
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF-TNRKVPYCVKFNPDEDKQN 389
H+ AV CF+ G + S D+ L+++ ETG+ + + C F+ D+
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR--- 659
Query: 390 LFVAGMS-DKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV--STSDDKSLRVWE 446
F+A S DKK+ W+ +GE+V YD H VN F + + + + S D L++W+
Sbjct: 660 -FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
Query: 447 WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIF---GAQNRFRLNKKKIFK 503
+ + + +S+ SP+ K LA S D + ++ A R +N K+ F
Sbjct: 719 LN-QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFL 777
Query: 504 GHMVAGYACQVDFSPDMSYVI-----SGDG-------NGKLNIWDWKTTKLYSRFKAHDK 551
D DM ++ S DG K+ +W+ + + + H
Sbjct: 778 N--------LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 829
Query: 552 VCIGAVWHPHETSKVITCGWDGLIKLWD 579
G ++ P + S +T D I+LW+
Sbjct: 830 WVHGVMFSP-DGSSFLTSSDDQTIRLWE 856
Score = 55.8 bits (133), Expect = 1e-07
Identities = 68/294 (23%), Positives = 116/294 (39%), Gaps = 18/294 (6%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GH V V P G L+ S D I+LWE ++ C + + + V D+ F
Sbjct: 826 GHLSWVHGVMFSP-DGSSFLTSSDDQTIRLWET--KKVCKNSAVMLKQEV-DVVFQENEV 881
Query: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDI 405
L+ + R L+L + TGQ I T +V C G + I ++
Sbjct: 882 MVLAVDHIRRLQLINGRTGQ-IDYLTEAQVSCCCL----SPHLQYIAFGDENGAIEILEL 936
Query: 406 RSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP 465
+ I Q +H V I F + + +S+SDD ++VW W + D ++
Sbjct: 937 VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVK 994
Query: 466 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVIS 525
L N + L+ S D + ++ N NK+K F H +C D S D + S
Sbjct: 995 DFRLLKNSRLLS-WSFDGTVKVW---NIITGNKEKDFVCHQGTVLSC--DISHDATKFSS 1048
Query: 526 GDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
+ IW + + H+ C+ +++ + T +G I++W+
Sbjct: 1049 TSADKTAKIWSFDLLLPLHELRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWN 1101
Score = 43.9 bits (102), Expect = 4e-04
Identities = 43/209 (20%), Positives = 87/209 (41%), Gaps = 8/209 (3%)
Query: 323 RCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFN 382
R ++ H K V I F +S++ D +++W+ + +CI +++ +
Sbjct: 940 RIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLL 999
Query: 383 PDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSL 442
K + ++ D + W+I +G +++ H G V + + +F STS DK+
Sbjct: 1000 ----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1055
Query: 443 RVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIF 502
++W +D+ + + + + S + LA + +I I+ N L+
Sbjct: 1056 KIWSFDLLLPLHELRGHN-GCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1114
Query: 503 KGHMVA---GYACQVDFSPDMSYVISGDG 528
A G+ + FSPD +IS G
Sbjct: 1115 SEEGAATHGGWVTDLCFSPDGKMLISAGG 1143
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 84.3 bits (207), Expect = 3e-16
Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 16/303 (5%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
++++ GH V A+ G + + S D KLW V +C TF GH+ + +
Sbjct: 125 EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE-TGKCYHTFRGHTAEIVCL 183
Query: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDKQNLFVAGMSD 397
FN T + + D KLWD + G+ + + FN D+ + G D
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR---IITGSFD 240
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
+V WD +G V H +++ F + ++ S DK+ ++W+ + K +A
Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD---ATNGKCVA 297
Query: 458 EPSMHSMPAVT--LSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD 515
+ H + GK +A S D IF A R + K +GH G ++
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK---LEGH--EGEISKIS 352
Query: 516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLI 575
F+P +++++G + IWD +T + + H ++ ++ + VIT D
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTC 411
Query: 576 KLW 578
++W
Sbjct: 412 RIW 414
Score = 79.3 bits (194), Expect = 9e-15
Identities = 69/270 (25%), Positives = 118/270 (43%), Gaps = 30/270 (11%)
Query: 273 KCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHS 332
KCY H + GHT + + P S L+ + SMD KLW++ + T GHS
Sbjct: 168 KCY------HTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNGEE-VYTLRGHS 219
Query: 333 KAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVK-----FNPDEDK 387
+ + FNT+G + ++ ++D + +WD +TG R N + +C + FN D
Sbjct: 220 AEIISLSFNTSGDRIITGSFDHTVVVWDADTG----RKVNILIGHCAEISSASFNWD--- 272
Query: 388 QNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW 447
+L + G DK WD +G+ V H + F + + S D + R++
Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS- 331
Query: 448 DIPVDFKYIAEPSMH--SMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
K IA+ H + ++ +P G L S D I+ AQ L ++ +GH
Sbjct: 332 --AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL---QVLEGH 386
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIW 535
++C ++ ++ VI+G + IW
Sbjct: 387 TDEIFSCAFNYKGNI--VITGSKDNTCRIW 414
Score = 72.0 bits (175), Expect = 1e-12
Identities = 59/253 (23%), Positives = 113/253 (44%), Gaps = 18/253 (7%)
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFT-NRKVPYCVKF-NPDEDKQ 388
H + ++ N +G+ F++ +YDR KLWDT +G+ ++ +R V Y + F NP DK
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDK- 149
Query: 389 NLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
G DK W + +G+ + H + + F ++ + S D + ++W+
Sbjct: 150 --IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 449 IPVDFKYIAEPSMHSMPAVTLSPN--GKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506
+ + + HS ++LS N G + S D+ ++++ A ++N I GH
Sbjct: 208 ---NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN---ILIGH- 260
Query: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV 566
F+ D S +++G + +WD K + HD + + + T K+
Sbjct: 261 -CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF--DYTGKL 317
Query: 567 I-TCGWDGLIKLW 578
I T DG +++
Sbjct: 318 IATASADGTARIF 330
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 84.0 bits (206), Expect = 4e-16
Identities = 74/302 (24%), Positives = 129/302 (42%), Gaps = 23/302 (7%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
K V GH V + G+ ++S S D +K+W +CLRT +GH+ V
Sbjct: 253 KSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWSAV-TGKCLRTLVGHTGGVWSS 309
Query: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCI-SRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 397
+S + DR LK+W+ ETG+CI + + + C+ + + V+G D
Sbjct: 310 --QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGSRD 362
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
+ WDI +G+ + H+ AV + + + RR VS + D ++VW+ P +
Sbjct: 363 ATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD---PETETCLH 417
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
H+ +L +G + S+D I ++ + N GH ++
Sbjct: 418 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETG---NCIHTLTGHQSLTSGMEL--- 471
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKL 577
+ ++SG+ + + IWD KT + + +K + VIT DG +KL
Sbjct: 472 -KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 530
Query: 578 WD 579
WD
Sbjct: 531 WD 532
Score = 65.5 bits (158), Expect = 1e-10
Identities = 65/293 (22%), Positives = 108/293 (36%), Gaps = 66/293 (22%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 340
IH GHT S VR L ++S S D +++W++ +CL +GH AVR C
Sbjct: 336 IHTLYGHT---STVRCMHLHEKRVVSGSRDATLRVWDIE-TGQCLHVLMGHVAAVR--CV 389
Query: 341 NTAGTQFLSAAYDRYLKLWDTETGQCISRF---TNRKVPYCVKFNPDEDKQNLFVAGMSD 397
G + +S AYD +K+WD ET C+ TNR Y ++F+ V+G D
Sbjct: 390 QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRV--YSLQFDGIH-----VVSGSLD 442
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
I WD+ +G + H + + D VS + D ++++W+ + +
Sbjct: 443 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQ 500
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
P+ H L N
Sbjct: 501 GPNKHQSAVTCLQFN--------------------------------------------- 515
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK-VCIGAVWHPHETSKVITC 569
++VI+ +G + +WD KT + + G VW ++ + C
Sbjct: 516 --KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 566
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 84.0 bits (206), Expect = 4e-16
Identities = 74/302 (24%), Positives = 129/302 (42%), Gaps = 23/302 (7%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
K V GH V + G+ ++S S D +K+W +CLRT +GH+ V
Sbjct: 371 KSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWSAV-TGKCLRTLVGHTGGVWSS 427
Query: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCI-SRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 397
+S + DR LK+W+ ETG+CI + + + C+ + + V+G D
Sbjct: 428 --QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGSRD 480
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
+ WDI +G+ + H+ AV + + + RR VS + D ++VW+ P +
Sbjct: 481 ATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD---PETETCLH 535
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
H+ +L +G + S+D I ++ + N GH ++
Sbjct: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETG---NCIHTLTGHQSLTSGMEL--- 589
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKL 577
+ ++SG+ + + IWD KT + + +K + VIT DG +KL
Sbjct: 590 -KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 648
Query: 578 WD 579
WD
Sbjct: 649 WD 650
Score = 65.5 bits (158), Expect = 1e-10
Identities = 65/293 (22%), Positives = 108/293 (36%), Gaps = 66/293 (22%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 340
IH GHT S VR L ++S S D +++W++ +CL +GH AVR C
Sbjct: 454 IHTLYGHT---STVRCMHLHEKRVVSGSRDATLRVWDIE-TGQCLHVLMGHVAAVR--CV 507
Query: 341 NTAGTQFLSAAYDRYLKLWDTETGQCISRF---TNRKVPYCVKFNPDEDKQNLFVAGMSD 397
G + +S AYD +K+WD ET C+ TNR Y ++F+ V+G D
Sbjct: 508 QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRV--YSLQFDGIH-----VVSGSLD 560
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
I WD+ +G + H + + D VS + D ++++W+ + +
Sbjct: 561 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQ 618
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
P+ H L N
Sbjct: 619 GPNKHQSAVTCLQFN--------------------------------------------- 633
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK-VCIGAVWHPHETSKVITC 569
++VI+ +G + +WD KT + + G VW ++ + C
Sbjct: 634 --KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 684
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 84.0 bits (206), Expect = 4e-16
Identities = 74/302 (24%), Positives = 129/302 (42%), Gaps = 23/302 (7%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
K V GH V + G+ ++S S D +K+W +CLRT +GH+ V
Sbjct: 291 KSPKVLKGHDDHV--ITCLQFCGNRIVSGSDDNTLKVWSAV-TGKCLRTLVGHTGGVWSS 347
Query: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCI-SRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 397
+S + DR LK+W+ ETG+CI + + + C+ + + V+G D
Sbjct: 348 --QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH-----EKRVVSGSRD 400
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
+ WDI +G+ + H+ AV + + + RR VS + D ++VW+ P +
Sbjct: 401 ATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWD---PETETCLH 455
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
H+ +L +G + S+D I ++ + N GH ++
Sbjct: 456 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETG---NCIHTLTGHQSLTSGMEL--- 509
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKL 577
+ ++SG+ + + IWD KT + + +K + VIT DG +KL
Sbjct: 510 -KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKL 568
Query: 578 WD 579
WD
Sbjct: 569 WD 570
Score = 65.5 bits (158), Expect = 1e-10
Identities = 65/293 (22%), Positives = 108/293 (36%), Gaps = 66/293 (22%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 340
IH GHT S VR L ++S S D +++W++ +CL +GH AVR C
Sbjct: 374 IHTLYGHT---STVRCMHLHEKRVVSGSRDATLRVWDIE-TGQCLHVLMGHVAAVR--CV 427
Query: 341 NTAGTQFLSAAYDRYLKLWDTETGQCISRF---TNRKVPYCVKFNPDEDKQNLFVAGMSD 397
G + +S AYD +K+WD ET C+ TNR Y ++F+ V+G D
Sbjct: 428 QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRV--YSLQFDGIH-----VVSGSLD 480
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457
I WD+ +G + H + + D VS + D ++++W+ + +
Sbjct: 481 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQ 538
Query: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517
P+ H L N
Sbjct: 539 GPNKHQSAVTCLQFN--------------------------------------------- 553
Query: 518 PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK-VCIGAVWHPHETSKVITC 569
++VI+ +G + +WD KT + + G VW ++ + C
Sbjct: 554 --KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 604
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 84.0 bits (206), Expect = 4e-16
Identities = 65/259 (25%), Positives = 115/259 (44%), Gaps = 19/259 (7%)
Query: 326 RTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPD 384
R F GH AV + F+ Q S + D L +W + RFT K CV F+P
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 385 EDKQNLFVAGMSDKKIVQW--DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSL 442
+L +G DK + W +++ V + H V ++ F + + FV+ SDDK++
Sbjct: 73 G---HLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 443 RVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 500
+VW K++ S H + SP+G+ + S D + ++ +R ++
Sbjct: 128 KVWATHRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS-- 182
Query: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHP 560
+ H G+ VDF P + + + + + +WD +T +L ++ H G +HP
Sbjct: 183 -YCEH--GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 561 HETSKVITCGWDGLIKLWD 579
+ +IT D +K+ D
Sbjct: 240 -SGNYLITASSDSTLKILD 257
Score = 72.0 bits (175), Expect = 1e-12
Identities = 67/278 (24%), Positives = 114/278 (41%), Gaps = 34/278 (12%)
Query: 284 WSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA 343
+ GH V+ V F ++ L S SMD + +W + + R R F GH AV + F+ +
Sbjct: 15 FKGHRDAVTCVD-FSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPS 72
Query: 344 GTQFLSAAYDRYLKLWDTETGQCISRF-----TNRKVPYCVKFNPDEDKQNLFVAGMSDK 398
G S + D+ +++W + F T R V +C D Q+ FV DK
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC------SDGQS-FVTASDDK 125
Query: 399 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458
+ W + + +H+ V F + R VS SDDK++++W+ +
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS--------SR 177
Query: 459 PSMHS-------MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYA 511
+HS + V P+G +A MDN + ++ + L ++ H A
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAA--V 232
Query: 512 CQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 549
+ F P +Y+I+ + L I D +L H
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Score = 66.2 bits (160), Expect = 8e-11
Identities = 44/179 (24%), Positives = 77/179 (43%), Gaps = 15/179 (8%)
Query: 279 KQIHVWSGH--------TKGVSAVRL--FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 328
K + VW+ H ++ ++ VR F G L++S S D +KLW+ R C+ ++
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSY 183
Query: 329 IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDK 387
H V + F+ +GT +A D +K+WD T + + + + F+P
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-- 241
Query: 388 QNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
N + SD + D+ G ++ H G T+ F F S D+ + VW+
Sbjct: 242 -NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 84.0 bits (206), Expect = 4e-16
Identities = 65/259 (25%), Positives = 115/259 (44%), Gaps = 19/259 (7%)
Query: 326 RTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPD 384
R F GH AV + F+ Q S + D L +W + RFT K CV F+P
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 385 EDKQNLFVAGMSDKKIVQW--DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSL 442
+L +G DK + W +++ V + H V ++ F + + FV+ SDDK++
Sbjct: 73 G---HLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 443 RVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 500
+VW K++ S H + SP+G+ + S D + ++ +R ++
Sbjct: 128 KVWATHRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS-- 182
Query: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHP 560
+ H G+ VDF P + + + + + +WD +T +L ++ H G +HP
Sbjct: 183 -YCEH--GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 561 HETSKVITCGWDGLIKLWD 579
+ +IT D +K+ D
Sbjct: 240 -SGNYLITASSDSTLKILD 257
Score = 72.0 bits (175), Expect = 1e-12
Identities = 67/278 (24%), Positives = 114/278 (41%), Gaps = 34/278 (12%)
Query: 284 WSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA 343
+ GH V+ V F ++ L S SMD + +W + + R R F GH AV + F+ +
Sbjct: 15 FKGHRDAVTCVD-FSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPS 72
Query: 344 GTQFLSAAYDRYLKLWDTETGQCISRF-----TNRKVPYCVKFNPDEDKQNLFVAGMSDK 398
G S + D+ +++W + F T R V +C D Q+ FV DK
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC------SDGQS-FVTASDDK 125
Query: 399 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458
+ W + + +H+ V F + R VS SDDK++++W+ +
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS--------SR 177
Query: 459 PSMHS-------MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYA 511
+HS + V P+G +A MDN + ++ + L ++ H A
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAA--V 232
Query: 512 CQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 549
+ F P +Y+I+ + L I D +L H
Sbjct: 233 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Score = 67.4 bits (163), Expect = 3e-11
Identities = 53/228 (23%), Positives = 97/228 (42%), Gaps = 26/228 (11%)
Query: 279 KQIHVWSGH--------TKGVSAVRL--FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 328
K + VW+ H ++ ++ VR F G L++S S D +KLW+ R C+ ++
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSY 183
Query: 329 IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDK 387
H V + F+ +GT +A D +K+WD T + + + + F+P
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG-- 241
Query: 388 QNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW 447
N + SD + D+ G ++ H G T+ F F S D+ + VW+
Sbjct: 242 -NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Query: 448 DIPV----DFKYIAEP------SMHSMPAVTLS-PNGKWLACQSMDNQ 484
+ + + + P SM ++P V P G+ + +S+ +Q
Sbjct: 301 NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQ 348
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 84.0 bits (206), Expect = 4e-16
Identities = 82/310 (26%), Positives = 133/310 (42%), Gaps = 22/310 (7%)
Query: 276 LPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER-RCLRTFIGHSKA 334
LP + V H V+AVR P S LL + D I LW V G R +T G +
Sbjct: 324 LPTRAQDVLDAHLSEVNAVRFGPNSS-LLATGGADRLIHLWNVVGSRLEANQTLEGAGGS 382
Query: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVA 393
+ + F+ +G Q L+A Y++ +LW Q + K KF + V
Sbjct: 383 ITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQA---VT 439
Query: 394 GMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDF 453
G D+ + +WD+ + + L N +V D +S +D+ +R W+ P
Sbjct: 440 GSRDRTVKEWDLGRAYCSRTINV-LSYCNDVVCGDHI--IISGHNDQKIRFWDSRGPHCT 496
Query: 454 KYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQ 513
+ I P + +++LS + L S DN + + + N +++F+ G+ C
Sbjct: 497 QVI--PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVS---NIRQVFRAD---GFKCG 548
Query: 514 VD-----FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVIT 568
D FSPD SY ++G +G L IWD T KL SR + + AV + S +++
Sbjct: 549 SDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVS 608
Query: 569 CGWDGLIKLW 578
+ LW
Sbjct: 609 VDQGRKVVLW 618
Score = 36.2 bits (82), Expect = 0.085
Identities = 34/157 (21%), Positives = 62/157 (39%), Gaps = 23/157 (14%)
Query: 302 HLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDT 361
H+++S D KI+ W+ G C + + V + + LS + D LK+ D
Sbjct: 474 HIIISGHNDQKIRFWDSRGPH-CTQVIPVQGR-VTSLSLSHDQLHLLSCSRDNTLKVIDL 531
Query: 362 ETG-----------QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI 410
+C S +T F+PD ++ +AG D + WD+ +G++
Sbjct: 532 RVSNIRQVFRADGFKCGSDWTK------AVFSPD---RSYALAGSCDGALYIWDVDTGKL 582
Query: 411 VQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
H AVN + + VS + + +W+
Sbjct: 583 ESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 83.6 bits (205), Expect = 5e-16
Identities = 66/271 (24%), Positives = 115/271 (42%), Gaps = 30/271 (11%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GHT V + F SG LL SCS D IKLW+ G C+RT GH V + G
Sbjct: 148 GHTDSVQDIS-FDHSGKLLASCSADMTIKLWDFQGFE-CIRTMHGHDHNVSSVAIMPNGD 205
Query: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDI 405
+SA+ D+ +K+W+ +TG C+ FT + + P++D L + +D+ + W +
Sbjct: 206 HIVSASRDKTIKMWEVQTGYCVKTFTGHR-EWVRMVRPNQD-GTLIASCSNDQTVRVWVV 263
Query: 406 RSGEIVQEYDRHLGAVNTIVFVDENRR--------------------FVSTSDDKSLRVW 445
+ E E H V I + E+ +S S DK++++W
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 446 EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
+ + + + + V GK++ + D + ++ +N+ R K H
Sbjct: 324 DVSTGMCLMTLVGHD-NWVRGVLFHSGGKFILSCADDKTLRVWDYKNK-RCMKTLNAHEH 381
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
V +DF YV++G + + +W+
Sbjct: 382 FVT----SLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/162 (20%), Positives = 71/162 (43%), Gaps = 7/162 (4%)
Query: 417 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWL 476
H V ++F VS S+D +++VW+++ DF+ + S+ ++ +GK L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFDHSGKLL 165
Query: 477 ACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
A S D I ++ Q F + H V+ A P+ +++S + + +W+
Sbjct: 166 ASCSADMTIKLWDFQG-FECIRTMHGHDHNVSSVA----IMPNGDHIVSASRDKTIKMWE 220
Query: 537 WKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578
+T F H + + V + + + +C D +++W
Sbjct: 221 VQTGYCVKTFTGH-REWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 35.8 bits (81), Expect = 0.11
Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 1/67 (1%)
Query: 513 QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWD 572
+V F P S ++S + + +WD++T K H + + H + +C D
Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTD-SVQDISFDHSGKLLASCSAD 171
Query: 573 GLIKLWD 579
IKLWD
Sbjct: 172 MTIKLWD 178
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 82.8 bits (203), Expect = 8e-16
Identities = 55/171 (32%), Positives = 86/171 (50%), Gaps = 7/171 (4%)
Query: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338
K + GH + ++ P G + S S D IKLW++ + C+ + GHS+AVR +
Sbjct: 96 KILRTLMGHKANICSLDFHPY-GEFVASGSQDTNIKLWDIR-RKGCVFRYRGHSQAVRCL 153
Query: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVAGMSD 397
F+ G SAA D +KLWD G+ +S F P V+F+P+E L +G SD
Sbjct: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE---YLLASGSSD 210
Query: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
+ I WD+ ++V + G V +++F + S D SLRV+ W+
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWE 260
Score = 81.6 bits (200), Expect = 2e-15
Identities = 67/261 (25%), Positives = 112/261 (42%), Gaps = 18/261 (6%)
Query: 287 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQ 346
H VS++ L SG LL + DC++ LW + + C+ + GH+ V + NT
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSI-NKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDKQNLFVA-GMSDKKIVQWD 404
++ + +++WD E + + K C + F+P + FVA G D I WD
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE----FVASGSQDTNIKLWD 133
Query: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSM 464
IR V Y H AV + F + + S +DD ++++W+ K ++E H+
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---KMMSEFPGHTG 190
Query: 465 P--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSY 522
P V PN LA S D I + + + +G G V F+PD
Sbjct: 191 PVNVVEFHPNEYLLASGSSDRTIRFWDLE---KFQVVSCIEGE--PGPVRSVLFNPDGCC 245
Query: 523 VISGDGNGKLNIWDWKTTKLY 543
+ SG L ++ W+ + +
Sbjct: 246 LYSG-CQDSLRVYGWEPERCF 265
Score = 50.4 bits (119), Expect = 4e-06
Identities = 40/190 (21%), Positives = 78/190 (41%), Gaps = 7/190 (3%)
Query: 390 LFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI 449
L G D ++ W I + H V ++ V+ S S+RVW+ +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 450 PVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAG 509
+ + + + ++ P G+++A S D I ++ + + + + ++GH A
Sbjct: 95 AKILRTLMGHKAN-ICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR---YRGHSQAV 150
Query: 510 YACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITC 569
+ FSPD ++ S + + +WD K+ S F H +HP+E + +
Sbjct: 151 RCLR--FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE-YLLASG 207
Query: 570 GWDGLIKLWD 579
D I+ WD
Sbjct: 208 SSDRTIRFWD 217
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/246 (24%), Positives = 105/246 (42%), Gaps = 18/246 (7%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GHT V R P GHL S S DC ++LW+V +CLR GH ++V + F+
Sbjct: 61 GHTGPVKFCRFSP-DGHLFASASCDCTVRLWDV-ARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDI 405
Q S +D+ + LWD ++GQ + + ++ + N G D + WD+
Sbjct: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHR--DSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Query: 406 R---SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMH 462
R Q + H ++ + + + S S DK++ +W+ P + + H
Sbjct: 177 RMVTPAVSHQALEGHSANISCLCY-SASGLLASGSWDKTIHIWK---PTTSSLLIQLKGH 232
Query: 463 S--MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM 520
+ ++ SP+ WLA + ++ L + KG + + C F+PD
Sbjct: 233 VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL---ETLKGVLDVAHTCA--FTPDG 287
Query: 521 SYVISG 526
++SG
Sbjct: 288 KILVSG 293
Score = 67.0 bits (162), Expect = 4e-11
Identities = 62/254 (24%), Positives = 112/254 (44%), Gaps = 13/254 (5%)
Query: 297 FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYL 356
F G +LL+ S D + WE + R GH+ V+ F+ G F SA+ D +
Sbjct: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASASCDCTV 87
Query: 357 KLWDTETGQCISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYD 415
+LWD +C+ +++ V F+PD + +G DK+++ WD++SG++++
Sbjct: 88 RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ---LASGGWDKRVMLWDVQSGQMLRLLV 144
Query: 416 RHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI--PVDFKYIAEPSMHSMPAVTLSPNG 473
H ++ + F + S D ++ +W+ + P E ++ + S +G
Sbjct: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
Query: 474 KWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLN 533
LA S D I I+ L + KGH+ + + FSPD ++ S + +
Sbjct: 205 L-LASGSWDKTIHIWKPTTSSLLIQ---LKGHVT--WVKSIAFSPDELWLASAGYSRMVK 258
Query: 534 IWDWKTTKLYSRFK 547
+WD T K K
Sbjct: 259 VWDCNTGKCLETLK 272
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 13/260 (5%)
Query: 323 RCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP--YCVK 380
R ++ F H V F+ G L+ + D + W+T +GQ + R P +C +
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC-R 70
Query: 381 FNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDK 440
F+PD +LF + D + WD+ + ++ H +V T+ F ++R+ S DK
Sbjct: 71 FSPD---GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDK 127
Query: 441 SLRVWEWDIPV-DFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKK 499
RV WD+ + S+ + SP LA S D+ + I+ +
Sbjct: 128 --RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
Query: 500 KIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWH 559
+ +GH A +C + + + SG + ++IW T+ L + K H +
Sbjct: 186 QALEGHS-ANISCLCYSASGL--LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 560 PHETSKVITCGWDGLIKLWD 579
P E + + G+ ++K+WD
Sbjct: 243 PDEL-WLASAGYSRMVKVWD 261
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 82.0 bits (201), Expect = 1e-15
Identities = 75/312 (24%), Positives = 131/312 (41%), Gaps = 23/312 (7%)
Query: 282 HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE-VYGE-RRCLR-----TFIGHSKA 334
H+ G V R P G L++ S+D I++W G+ R+ L+ F+ A
Sbjct: 208 HIKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDA 266
Query: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF--TNRKVPYCVKFNPDEDKQNLFV 392
V +CF+ + A D +K+W ++GQC+ RF + K C+ F+ D + +
Sbjct: 267 VLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ---IL 323
Query: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW---DI 449
+ D+ I ++SG+ ++E+ H VN F + +S S D ++++W +
Sbjct: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
Query: 450 PVDFKYI---AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506
FK + A + + L N + + N ++I Q + + G
Sbjct: 384 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQI---VRSFSSGKR 440
Query: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV 566
G SP ++ + L + T KL H+K IG HPH+ + +
Sbjct: 441 EGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQ-NLI 499
Query: 567 ITCGWDGLIKLW 578
T DGL+KLW
Sbjct: 500 ATYSEDGLLKLW 511
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQN 389
H+ + F + Q L+A+ D LWD E+GQ + F C+ P E N
Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETG-N 210
Query: 390 LFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI 449
FV+G DKK + WD+RSG+ VQ ++ H +N++ + F S SDD + R+ +D+
Sbjct: 211 TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL--YDL 268
Query: 450 PVDFK---YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506
D + Y E + +V S +G+ L+F N + +N + KG
Sbjct: 269 RADREVAIYSKESIIFGASSVDFSLSGR-----------LLFAGYNDYTINVWDVLKGSR 317
Query: 507 VA---GYACQVD---FSPDMSYVISGDGNGKLNIW 535
V+ G+ +V SPD + SG + L +W
Sbjct: 318 VSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 2/161 (1%)
Query: 286 GHTKGVSAVRLFPL-SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
GH V + L P +G+ +S D K +W++ + C++ F H + + + +G
Sbjct: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ-CVQAFETHESDINSVRYYPSG 251
Query: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404
F S + D +L+D + ++ ++ + + L AG +D I WD
Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
Query: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW 445
+ G V H V+T+ + F S S D +LRVW
Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/182 (25%), Positives = 79/182 (43%), Gaps = 15/182 (8%)
Query: 408 GEIVQEYDRHL-GAVNTIVFVD---ENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463
G+ V + R L G N ++ +D + RR VS+S D + VW+ + P
Sbjct: 49 GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWV 108
Query: 464 MPAVTLSPNGKWLACQSMDNQILIFGA---QNRFRLNKKKIFKGHMVAGYACQVDFSPDM 520
M A +P+G +AC +DN+ ++ +N KKK H Y F+
Sbjct: 109 M-ACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH--TNYLSACSFTNSD 165
Query: 521 SYVISGDGNGKLNIWDWKTTKLYSRFKAH--DKVCIGAVWHPHETSKV-ITCGWDGLIKL 577
+++ G+G +WD ++ +L F H D +C+ P ET ++ G D +
Sbjct: 166 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLA--PSETGNTFVSGGCDKKAMV 223
Query: 578 WD 579
WD
Sbjct: 224 WD 225
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQN 389
H+ + F + Q L+A+ D LWD E+GQ + F C+ P E N
Sbjct: 194 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETG-N 252
Query: 390 LFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI 449
FV+G DKK + WD+RSG+ VQ ++ H +N++ + F S SDD + R+ +D+
Sbjct: 253 TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL--YDL 310
Query: 450 PVDFK---YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506
D + Y E + +V S +G+ L+F N + +N + KG
Sbjct: 311 RADREVAIYSKESIIFGASSVDFSLSGR-----------LLFAGYNDYTINVWDVLKGSR 359
Query: 507 VA---GYACQVD---FSPDMSYVISGDGNGKLNIW 535
V+ G+ +V SPD + SG + L +W
Sbjct: 360 VSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 2/161 (1%)
Query: 286 GHTKGVSAVRLFPL-SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
GH V + L P +G+ +S D K +W++ + C++ F H + + + +G
Sbjct: 235 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ-CVQAFETHESDINSVRYYPSG 293
Query: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404
F S + D +L+D + ++ ++ + + L AG +D I WD
Sbjct: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
Query: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW 445
+ G V H V+T+ + F S S D +LRVW
Sbjct: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/182 (25%), Positives = 79/182 (43%), Gaps = 15/182 (8%)
Query: 408 GEIVQEYDRHL-GAVNTIVFVD---ENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463
G+ V + R L G N ++ +D + RR VS+S D + VW+ + P
Sbjct: 91 GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWV 150
Query: 464 MPAVTLSPNGKWLACQSMDNQILIFGA---QNRFRLNKKKIFKGHMVAGYACQVDFSPDM 520
M A +P+G +AC +DN+ ++ +N KKK H Y F+
Sbjct: 151 M-ACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH--TNYLSACSFTNSD 207
Query: 521 SYVISGDGNGKLNIWDWKTTKLYSRFKAH--DKVCIGAVWHPHETSKV-ITCGWDGLIKL 577
+++ G+G +WD ++ +L F H D +C+ P ET ++ G D +
Sbjct: 208 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLA--PSETGNTFVSGGCDKKAMV 265
Query: 578 WD 579
WD
Sbjct: 266 WD 267
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 81.3 bits (199), Expect = 2e-15
Identities = 96/381 (25%), Positives = 160/381 (41%), Gaps = 42/381 (11%)
Query: 210 EEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTM 269
+E QK++D+ K +KK K K EE ++V+ + + +I +
Sbjct: 312 KEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDL- 370
Query: 270 PPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFI 329
IH G K V F L +L+ S++ + + R T
Sbjct: 371 -----------IHSPHGELKAV-----FLLQNNLVELYSLNPSLPTPQPVRTSRI--TIG 412
Query: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQN 389
GH VR + F++ LSAA D +K+W+ T QCI T + C F P D+Q
Sbjct: 413 GHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMT-CEYALCSFFVPG-DRQ- 468
Query: 390 LFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI 449
V G K+ +D+ SG +++ D H GA+ ++ + R FV+ DKS++ W++++
Sbjct: 469 -VVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFEL 527
Query: 450 PVD----FKYIAEPSMHSMP------AVTLSPNGKWLACQSMDNQILIFGAQN-RFRLNK 498
D K ++ ++ V+ SPN K LA +D + IF +F L+
Sbjct: 528 VKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLS- 586
Query: 499 KKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVW 558
GH + +D S D + + +G + + IW + AHD + +
Sbjct: 587 ---LYGHKLP--VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
Query: 559 HPHETSKVITCGWDGLIKLWD 579
P ++ T G D IK WD
Sbjct: 642 VP-KSHLFFTAGKDHKIKQWD 661
Score = 57.4 bits (137), Expect = 4e-08
Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 5/145 (3%)
Query: 303 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 362
LL +DC +K++ V + L + GH V + + G + + DR +K+W +
Sbjct: 563 LLAVSLLDCTVKIFYVDTLKFFLSLY-GHKLPVICMDISHDGALIATGSADRNVKIWGLD 621
Query: 363 TGQCI-SRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAV 421
G C S F + ++F P K +LF D KI QWD E +Q + H +
Sbjct: 622 FGDCHKSLFAHDDSVMYLQFVP---KSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEI 678
Query: 422 NTIVFVDENRRFVSTSDDKSLRVWE 446
+ VS+S DKSLR+WE
Sbjct: 679 WCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 2/120 (1%)
Query: 327 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDED 386
TF GH A+ + ++ G + S + D + +WD + R K E
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLRE- 160
Query: 387 KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
+NL V D + WD+ + + H V +V + E +R ++ + D LRVW+
Sbjct: 161 -KNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 37.0 bits (84), Expect = 0.050
Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 2/75 (2%)
Query: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
GH ++ LF +LL++ D +K W++ + C +T +GH V + +
Sbjct: 147 GHKDAITQA-LFLREKNLLVTSGKDTMVKWWDL-DTQHCFKTMVGHRTEVWGLVLLSEEK 204
Query: 346 QFLSAAYDRYLKLWD 360
+ ++ A D L++WD
Sbjct: 205 RLITGASDSELRVWD 219
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 81.3 bits (199), Expect = 2e-15
Identities = 54/216 (25%), Positives = 99/216 (45%), Gaps = 7/216 (3%)
Query: 280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDIC 339
++ + GH V + R S LL SCS D I+ W++ G + GH+ V D+
Sbjct: 334 EMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDL-GSFTNTVLYQGHAYPVWDLD 391
Query: 340 FNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVAGMSDK 398
+ F S ++DR +LW + + + CVKF+P+ N G +DK
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNS---NYLATGSTDK 448
Query: 399 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458
+ W + G V+ + H G V ++ F + S +D+ L++W+ +K +
Sbjct: 449 TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL-R 507
Query: 459 PSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRF 494
++ ++T SP+ +A SMDN + ++ +N +
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/183 (24%), Positives = 77/183 (42%), Gaps = 7/183 (3%)
Query: 397 DKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYI 456
D I WD+ S Y H V + + F S S D++ R+W +D +
Sbjct: 363 DMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIY 422
Query: 457 AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDF 516
A + + V PN +LA S D + ++ AQ N ++F GH G + F
Sbjct: 423 AG-HLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG---NSVRLFTGHR--GPVLSLAF 476
Query: 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIK 576
SP+ Y+ S + +L +WD + LY + H + P ++ + + D ++
Sbjct: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVR 535
Query: 577 LWD 579
+WD
Sbjct: 536 VWD 538
Score = 51.6 bits (122), Expect = 2e-06
Identities = 52/218 (23%), Positives = 88/218 (40%), Gaps = 22/218 (10%)
Query: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV----PYCVKFNPDE 385
GH V F + LS + D ++ WD + FTN + Y V ++ D
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWD------LGSFTNTVLYQGHAYPV-WDLDI 392
Query: 386 DKQNL-FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRV 444
+L F +G D+ W ++ Y HL V+ + F + + S DK++R+
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 445 WEWDIPVDFKYIAEPSMHSMPAVTL--SPNGKWLACQSMDNQILIFGAQNRFRLNKKKIF 502
W + H P ++L SPNGK+LA D ++ ++ + K
Sbjct: 453 WSAQQGNSVRLFTG---HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG---TLYKEL 506
Query: 503 KGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT 540
+GH + FSPD + S + + +WD + T
Sbjct: 507 RGH--TDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Score = 37.0 bits (84), Expect = 0.050
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 2/86 (2%)
Query: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 340
+ +++GH V ++ P +G L S D ++KLW++ + GH+ + + F
Sbjct: 461 VRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDL-ASGTLYKELRGHTDNITSLTF 518
Query: 341 NTAGTQFLSAAYDRYLKLWDTETGQC 366
+ SA+ D +++WD C
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRNTYC 544
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 79.3 bits (194), Expect = 9e-15
Identities = 98/379 (25%), Positives = 159/379 (41%), Gaps = 38/379 (10%)
Query: 201 DEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSY------ 254
+EKD + QKEL E + + ++ + ++T H +E + S
Sbjct: 209 NEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAISRAATRRS 268
Query: 255 ---LHIPQDVGVNLRSTMPP--EKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSM 309
+PQD N+ T P ++ +P + V+ H V+AV+ P S LL + M
Sbjct: 269 VSSFPVPQD---NV-DTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGS-RLLATGGM 323
Query: 310 DCKIKLWEVYGERRCLRTFIGHSKA-VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCIS 368
D ++KLWEV+GE+ + + S A + I F++AG+ L+A+ D ++W + +
Sbjct: 324 DRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRH 383
Query: 369 RFTNRKVPYC-VKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV 427
T KF D + V+G D+ + WD+RS ++ + N IV
Sbjct: 384 TLTGHSGKVLSAKFLLDNAR---IVSGSHDRTLKLWDLRSKVCIKTVFAG-SSCNDIVCT 439
Query: 428 DENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILI 487
++ +S DK +R W DI + + + A+ L+P L S D+ + +
Sbjct: 440 EQC--VMSGHFDKKIRFW--DIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKV 495
Query: 488 FGAQNRFRLNKKKIFKGHMVAGYACQVD-----FSPDMSYVISGDGNGKLNIWDWKTTKL 542
L I + G+ C D FSPD SYV +G G L IW T K+
Sbjct: 496 ID------LRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKV 549
Query: 543 YSRFKAHDKVCIGAV-WHP 560
I AV W P
Sbjct: 550 EKVLSKQHSSSINAVAWSP 568
Score = 78.2 bits (191), Expect = 2e-14
Identities = 75/260 (28%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
SG G++++ F +G LL+ S D ++W V + R T GHS V F
Sbjct: 344 SGSNAGITSIE-FDSAGSYLLAASNDFASRIWTV-DDYRLRHTLTGHSGKVLSAKFLLDN 401
Query: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404
+ +S ++DR LKLWD + CI + V N + ++G DKKI WD
Sbjct: 402 ARIVSGSHDRTLKLWDLRSKVCI-----KTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWD 456
Query: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSM 464
IRS IV+E + LG + + E +S S D L+V +D + A S
Sbjct: 457 IRSESIVREMEL-LGKITALDLNPERTELLSCSRDDLLKV------IDLRTNAIKQTFSA 509
Query: 465 PA---------VTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD 515
P V SP+G ++A S + + I+ +K + K H + A V
Sbjct: 510 PGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLT--GKVEKVLSKQHSSSINA--VA 565
Query: 516 FSPDMSYVISGDGNGKLNIW 535
+SP S+V+S D K +W
Sbjct: 566 WSPSGSHVVSVDKGCKAVLW 585
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 79.3 bits (194), Expect = 9e-15
Identities = 67/265 (25%), Positives = 111/265 (41%), Gaps = 29/265 (10%)
Query: 325 LRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPD 384
L+T AVR + FN G L+ D+ LKLW+ G + ++ Y V
Sbjct: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHG--YEVLDAAG 75
Query: 385 EDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRV 444
+ +G DK +V WD+ SG++V+++ H G VNT+ F +E +S S D S+R
Sbjct: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
Query: 445 WEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM-DNQIL---IFGAQNRFRLNKKK 500
W+ S P TL ++ + D++IL + G R+ L +
Sbjct: 136 WDC-----------RSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQ 184
Query: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK------VCI 554
+F ++ + C FS D + + L + D T +L +K H C+
Sbjct: 185 LFSDYVGSPITCTC-FSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCL 243
Query: 555 GAVWHPHETSKVITCGWDGLIKLWD 579
+ V++C DG + WD
Sbjct: 244 S-----ERDTHVVSCSEDGKVFFWD 263
Score = 77.4 bits (189), Expect = 3e-14
Identities = 79/313 (25%), Positives = 128/313 (40%), Gaps = 23/313 (7%)
Query: 270 PPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFI 329
PPE LP+K++ V AVR F + G+ L+C D +KLW LRT+
Sbjct: 10 PPE---LPQKRLKTLDCGQGAVRAVR-FNVDGNYCLTCGSDKTLKLWNPL-RGTLLRTYS 64
Query: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQ 388
GH V D + + S D+ + LWD +GQ + +F V+FN ++
Sbjct: 65 GHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFN---EEA 121
Query: 389 NLFVAGMSDKKIVQWDIRSG--EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
+ ++G D I WD RS E VQ D V+++ D ++ S D +R ++
Sbjct: 122 TVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYD 179
Query: 447 WDIPVDFK-YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
+ F Y+ P + S +G+ S+D+ + + L + +KGH
Sbjct: 180 LRMGQLFSDYVGSP----ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGE---YKGH 232
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565
Y S ++V+S +GK+ WD L V +HP E
Sbjct: 233 KNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCL 292
Query: 566 VITCGWDGLIKLW 578
+ G G ++ W
Sbjct: 293 LTAMG--GSVQCW 303
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 79.3 bits (194), Expect = 9e-15
Identities = 67/265 (25%), Positives = 111/265 (41%), Gaps = 29/265 (10%)
Query: 325 LRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPD 384
L+T AVR + FN G L+ D+ LKLW+ G + ++ Y V
Sbjct: 18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHG--YEVLDAAG 75
Query: 385 EDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRV 444
+ +G DK +V WD+ SG++V+++ H G VNT+ F +E +S S D S+R
Sbjct: 76 SFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRC 135
Query: 445 WEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM-DNQIL---IFGAQNRFRLNKKK 500
W+ S P TL ++ + D++IL + G R+ L +
Sbjct: 136 WDC-----------RSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQ 184
Query: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK------VCI 554
+F ++ + C FS D + + L + D T +L +K H C+
Sbjct: 185 LFSDYVGSPITCTC-FSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCL 243
Query: 555 GAVWHPHETSKVITCGWDGLIKLWD 579
+ V++C DG + WD
Sbjct: 244 S-----ERDTHVVSCSEDGKVFFWD 263
Score = 77.4 bits (189), Expect = 3e-14
Identities = 79/313 (25%), Positives = 128/313 (40%), Gaps = 23/313 (7%)
Query: 270 PPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFI 329
PPE LP+K++ V AVR F + G+ L+C D +KLW LRT+
Sbjct: 10 PPE---LPQKRLKTLDCGQGAVRAVR-FNVDGNYCLTCGSDKTLKLWNPL-RGTLLRTYS 64
Query: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQ 388
GH V D + + S D+ + LWD +GQ + +F V+FN ++
Sbjct: 65 GHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFN---EEA 121
Query: 389 NLFVAGMSDKKIVQWDIRSG--EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
+ ++G D I WD RS E VQ D V+++ D ++ S D +R ++
Sbjct: 122 TVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYD 179
Query: 447 WDIPVDFK-YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505
+ F Y+ P + S +G+ S+D+ + + L + +KGH
Sbjct: 180 LRMGQLFSDYVGSP----ITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGE---YKGH 232
Query: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565
Y S ++V+S +GK+ WD L V +HP E
Sbjct: 233 KNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCL 292
Query: 566 VITCGWDGLIKLW 578
+ G G ++ W
Sbjct: 293 LTAMG--GSVQCW 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,460,735
Number of Sequences: 37866
Number of extensions: 1111650
Number of successful extensions: 9104
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 209
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 6191
Number of HSP's gapped (non-prelim): 1933
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.