Guide to the Human Genome
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Search of human proteins with 7705413

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7705413 neurotrimin isoform 1 [Homo sapiens]
         (344 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7705413 neurotrimin isoform 1 [Homo sapiens]                       701   0.0  
gi|221316757 neurotrimin isoform 3 [Homo sapiens]                     692   0.0  
gi|115298665 neurotrimin isoform 2 [Homo sapiens]                     645   0.0  
gi|221316762 neurotrimin isoform 4 [Homo sapiens]                     637   0.0  
gi|4505505 opioid binding protein/cell adhesion molecule-like is...   547   e-156
gi|59939900 opioid binding protein/cell adhesion molecule-like i...   493   e-140
gi|45594240 limbic system-associated membrane protein [Homo sapi...   374   e-104
gi|66346706 neuronal growth regulator 1 [Homo sapiens]                322   4e-88
gi|157819143 IgLON family member 5 [Homo sapiens]                     295   5e-80
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        105   5e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   105   5e-23
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...   105   5e-23
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]     103   2e-22
gi|118572606 hemicentin 1 [Homo sapiens]                              103   2e-22
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi...   102   4e-22
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap...   102   4e-22
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap...    99   6e-21
gi|110349719 titin isoform N2-A [Homo sapiens]                         97   2e-20
gi|109150416 peroxidasin [Homo sapiens]                                97   2e-20
gi|24111244 MAM domain containing glycosylphosphatidylinositol a...    91   1e-18
gi|4827022 contactin 2 precursor [Homo sapiens]                        90   3e-18
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]       89   4e-18
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]             89   6e-18
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]             89   6e-18
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...    87   2e-17
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    86   6e-17
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    86   6e-17
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]          85   1e-16
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    84   2e-16
gi|7657361 contactin 6 [Homo sapiens]                                  84   2e-16

>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
          Length = 344

 Score =  701 bits (1809), Expect = 0.0
 Identities = 344/344 (100%), Positives = 344/344 (100%)

Query: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
           MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60

Query: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
           NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120

Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
           NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180

Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
           SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240

Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
           LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300

Query: 301 LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
           LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Sbjct: 301 LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344


>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
          Length = 355

 Score =  692 bits (1787), Expect = 0.0
 Identities = 344/355 (96%), Positives = 344/355 (96%), Gaps = 11/355 (3%)

Query: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
           MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60

Query: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
           NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120

Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
           NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180

Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
           SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240

Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
           LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300

Query: 301 LGHTNASIMLF-----------GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
           LGHTNASIMLF           GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Sbjct: 301 LGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 355


>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
          Length = 344

 Score =  645 bits (1663), Expect = 0.0
 Identities = 317/317 (100%), Positives = 317/317 (100%)

Query: 28  GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR 87
           GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR
Sbjct: 28  GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR 87

Query: 88  VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI 147
           VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI
Sbjct: 88  VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI 147

Query: 148 NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
           NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV
Sbjct: 148 NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207

Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
           AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK
Sbjct: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267

Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA 327
           GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA
Sbjct: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA 327

Query: 328 GCVWLLPLLVLHLLLKF 344
           GCVWLLPLLVLHLLLKF
Sbjct: 328 GCVWLLPLLVLHLLLKF 344


>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
          Length = 316

 Score =  637 bits (1644), Expect = 0.0
 Identities = 312/312 (100%), Positives = 312/312 (100%)

Query: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
           MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60

Query: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
           NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120

Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
           NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180

Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
           SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240

Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
           LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300

Query: 301 LGHTNASIMLFG 312
           LGHTNASIMLFG
Sbjct: 301 LGHTNASIMLFG 312


>gi|4505505 opioid binding protein/cell adhesion molecule-like
           isoform a preproprotein [Homo sapiens]
          Length = 345

 Score =  547 bits (1410), Expect = e-156
 Identities = 264/345 (76%), Positives = 298/345 (86%), Gaps = 1/345 (0%)

Query: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
           MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1   MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60

Query: 61  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
           +RVTRVAWLNRSTILYAGNDKW +DPRV++L NT TQYSI IQNVDVYDEGPYTCSVQTD
Sbjct: 61  DRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTD 120

Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-AVGF 179
           NHPKTSRVHLIVQV P+I+ ISSDI++NEG++++L C+A GRPEPTVTWRH+S K   GF
Sbjct: 121 NHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGF 180

Query: 180 VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKG 239
           VSEDEYLEI  I R+QSG+YECSA NDVAAP VR+VK+TVNYPPYIS+AK TGV VGQKG
Sbjct: 181 VSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKG 240

Query: 240 TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASN 299
            L CEASAVP AEFQW+K++ RL  G  G+++EN+  +S L FFNVSE DYGNYTCVA+N
Sbjct: 241 ILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATN 300

Query: 300 KLGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
           KLG+TNASI L+GPGAV +  N  SR   C+WL   L+ H  +KF
Sbjct: 301 KLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF 345


>gi|59939900 opioid binding protein/cell adhesion molecule-like
           isoform b preproprotein [Homo sapiens]
          Length = 338

 Score =  493 bits (1270), Expect = e-140
 Identities = 241/331 (72%), Positives = 275/331 (83%), Gaps = 1/331 (0%)

Query: 15  VVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTI 74
           VV S     L   GVPVRSGDATFPKAMDNVTVRQGESATLRCTID+RVTRVAWLNRSTI
Sbjct: 8   VVFSATTALLFIPGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTI 67

Query: 75  LYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 134
           LYAGNDKW +DPRV++L NT TQYSI IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV
Sbjct: 68  LYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 127

Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-AVGFVSEDEYLEIQGITR 193
            P+I+ ISSDI++NEG++++L C+A GRPEPTVTWRH+S K   GFVSEDEYLEI  I R
Sbjct: 128 PPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKR 187

Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEF 253
           +QSG+YECSA NDVAAP VR+VK+TVNYPPYIS+AK TGV VGQKG L CEASAVP AEF
Sbjct: 188 DQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEF 247

Query: 254 QWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGP 313
           QW+K++ RL  G  G+++EN+  +S L FFNVSE DYGNYTCVA+NKLG+TNASI L+GP
Sbjct: 248 QWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGP 307

Query: 314 GAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
           GAV +  N  SR   C+WL   L+ H  +KF
Sbjct: 308 GAVIDGVNSASRALACLWLSGTLLAHFFIKF 338


>gi|45594240 limbic system-associated membrane protein [Homo
           sapiens]
          Length = 338

 Score =  374 bits (959), Expect = e-104
 Identities = 186/332 (56%), Positives = 248/332 (74%), Gaps = 4/332 (1%)

Query: 12  KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
           K L +V LRLL L+PTG+PVRS D  F +  DN+TVRQG++A LRC ++++ ++VAWLNR
Sbjct: 10  KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67

Query: 72  STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
           S I++AG+DKW LDPRV L      +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 68  SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127

Query: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
           VQV PKI  ISSD+++NEG+N++L C+A GRPEP +TWRH++P    F  E+EYLEI GI
Sbjct: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGI 187

Query: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSA 251
           TREQSG YEC A+N+V++  V++VKVTVNYPP I+E+K      G++ +L+CEASAVP+ 
Sbjct: 188 TREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAP 247

Query: 252 EFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
           +F+WY+DD R I    G+++++    S L   NV+E  YGNYTCVA+NKLG TNAS++LF
Sbjct: 248 DFEWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306

Query: 312 GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLK 343
            PG+V  + NG+   A  +WLL   +L LL K
Sbjct: 307 RPGSVRGI-NGSISLAVPLWLLAASLLCLLSK 337


>gi|66346706 neuronal growth regulator 1 [Homo sapiens]
          Length = 354

 Score =  322 bits (824), Expect = 4e-88
 Identities = 158/323 (48%), Positives = 223/323 (69%), Gaps = 3/323 (0%)

Query: 14  LVVVSLRLLFLVPTGVPVRSGDATFP-KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRS 72
           L  V L L  L+P+ +P       FP  A+DN+ VR+G++A LRC +++  ++ AWLNRS
Sbjct: 17  LAAVLLSLCCLLPSCLPAGQS-VDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRS 75

Query: 73  TILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIV 132
           +I++AG DKW +DPRV + +  +  YS++IQNVDV D+GPYTCSVQT + P+T +VHL V
Sbjct: 76  SIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTV 135

Query: 133 QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGIT 192
           QV PKI +IS+D+++NEG N++LTC+ATG+PEP+++WRHISP A  F    +YL+I GIT
Sbjct: 136 QVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPF-ENGQYLDIYGIT 194

Query: 193 REQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE 252
           R+Q+G+YECSA NDV+ P VR+VKV VN+ P I E K   V  G+ G ++CE + VP   
Sbjct: 195 RDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPA 254

Query: 253 FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFG 312
           F+WYK +K+L  G++G+ ++N    S L   NV++  +GNYTCVA+NKLG TNAS+ L  
Sbjct: 255 FEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP 314

Query: 313 PGAVSEVSNGTSRRAGCVWLLPL 335
           P        G++      W L L
Sbjct: 315 PSTAQYGITGSADVLFSCWYLVL 337


>gi|157819143 IgLON family member 5 [Homo sapiens]
          Length = 336

 Score =  295 bits (754), Expect = 5e-80
 Identities = 163/327 (49%), Positives = 211/327 (64%), Gaps = 10/327 (3%)

Query: 12  KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
           + L   +L  L ++  G+  +S +   P   DN TV +G++ATL C ID  VTRVAWLNR
Sbjct: 11  RLLAAAALAGLAVISRGLLSQSLEFNSPA--DNYTVCEGDNATLSCFIDEHVTRVAWLNR 68

Query: 72  STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
           S ILYAGND+W  DPRV LL NT  ++SI I  V + DEG YTCS QT + P T++V+LI
Sbjct: 69  SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLI 128

Query: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
           V V  +IV ISS +++NEG N++L C+A GRPEPTVTWR +     GF SE E LEI  I
Sbjct: 129 VHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRD---GFTSEGEILEISDI 185

Query: 192 TREQSGDYECSASNDV-AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPS 250
            R Q+G+YEC   N V +AP  RRV VTVNYPP I++       +G+   L+CEA AVP 
Sbjct: 186 QRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPP 245

Query: 251 AEFQWYKDDKRLIEG-KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIM 309
           A+FQWYKDD+ L  G  +G+KV+     S L+F NVS   YGNYTC A+N+LG ++AS+ 
Sbjct: 246 ADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGASSASMR 305

Query: 310 LFGPGAVSEVSNGTSRRAGCVWLLPLL 336
           L  PG+   + N   R  G + LL  L
Sbjct: 306 LLRPGS---LENSAPRPPGLLALLSAL 329


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  105 bits (263), Expect = 5e-23
 Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)

Query: 44  NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           NVTV  GE+A L C +       + W+    +L A         RV  L++     S+EI
Sbjct: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 457

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
             +   D G Y C     N    + V L+V+ +P++   +S    ++G  + ++C A+G 
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 517

Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
           P P ++W    + +   +   V     L IQG+  E +G+Y C A+N+V      +  VT
Sbjct: 518 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 574

Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           + Y  PP +S       V VG++  L CEAS VP     WY+    +I   +G       
Sbjct: 575 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 629

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              KL      E D G YTC A N+LG  +A I L
Sbjct: 630 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 78/282 (27%), Positives = 112/282 (39%), Gaps = 34/282 (12%)

Query: 45  VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
           V V  GE A L C        RV W       Y G  +  L P         +   + I 
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIW-------YRGGLEMILAPE------GSSSGKLRIP 636

Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
                D G YTC    +    ++ + L V  +P++ E+  D+++  G +  L C ATGRP
Sbjct: 637 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 696

Query: 164 EPTVTWRHISPKAVGF-----------VSEDEYLEIQGITREQSGDYECSASNDVA-APV 211
            PTVTWR    + +G              +   L  + +  E    Y C A N       
Sbjct: 697 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQA 756

Query: 212 VRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK-G 268
             R+ VT + PP I S A    V  GQ  +L C   A  P  E  W KD + L  G +  
Sbjct: 757 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 816

Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           ++ +    L + +     EH  G Y+CVA+N  G  +  + L
Sbjct: 817 IRADGSLHLDRAL----QEH-AGRYSCVATNTAGSQHRDVEL 853



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 63/222 (28%), Positives = 103/222 (46%), Gaps = 21/222 (9%)

Query: 111  GPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW- 169
            G Y+C        +   V L+VQV P+I   ++    NEG   SL C+A+G P PT+TW 
Sbjct: 834  GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 893

Query: 170  ---RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP-- 223
                 ++ +   + VS++  L I   + + +G Y C+A+N V     + ++++VN  P  
Sbjct: 894  KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRI 952

Query: 224  YISEAKGTGVPV------GQKGTLQCEASAVPSAEFQWYKDDKRL--IEGKKGVKVENRP 275
            +++ ++   VP+      G++ TL CEA   P     W KD + +  I  + G+      
Sbjct: 953  HMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS--- 1009

Query: 276  FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
                L    V   D G+Y C ASN  G  +   +L   G  S
Sbjct: 1010 --GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
           S EI      +EG Y C+  +      ++  ++V   P  +  + +++++ G    L+C 
Sbjct: 363 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 422

Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
             G     +TW     + P + G V++  D  LEI GI     G Y+C ASN  A  V R
Sbjct: 423 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 480

Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
             V + V   P +S          G +  + C AS  P+    W ++ + L E  + + V
Sbjct: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 539

Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
           + +     LI   V+  D GNY+C A+N++G    ++ L+   P +VS V+
Sbjct: 540 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 587



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 43/191 (22%), Positives = 69/191 (36%), Gaps = 26/191 (13%)

Query: 39   PKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
            P A  ++T  +G  A+L C         + W   +  L +    +          N   +
Sbjct: 863  PTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY----------NVSKE 911

Query: 98   YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-------VEISSDISINEG 150
             ++ I      D G Y C+        +  + L V   P+I         +   ++   G
Sbjct: 912  GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAG 971

Query: 151  NNISLTCIATGRPEPTVTW----RHISP--KAVGFVSEDEYLEIQGITREQSGDYECSAS 204
              ++L C A G P P VTW    R + P     G +     L +  +    SG YEC+AS
Sbjct: 972  EEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTAS 1030

Query: 205  NDVAAPVVRRV 215
            N   +   R V
Sbjct: 1031 NPAGSASHRYV 1041


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  105 bits (263), Expect = 5e-23
 Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)

Query: 44  NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           NVTV  GE+A L C +       + W+    +L A         RV  L++     S+EI
Sbjct: 525 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 574

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
             +   D G Y C     N    + V L+V+ +P++   +S    ++G  + ++C A+G 
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 634

Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
           P P ++W    + +   +   V     L IQG+  E +G+Y C A+N+V      +  VT
Sbjct: 635 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 691

Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           + Y  PP +S       V VG++  L CEAS VP     WY+    +I   +G       
Sbjct: 692 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 746

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              KL      E D G YTC A N+LG  +A I L
Sbjct: 747 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780



 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            + I +    D G Y C  +        +  L+VQV P I     D+S  EG++  L C A
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061

Query: 160  TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
             G PEP +TW        G      +     L ++ +  + +G Y C+A N V     RR
Sbjct: 4062 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 4120

Query: 215  VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V +T+   P  +   G   + +G +  L+C A   P+    W  +D+ + EG     V  
Sbjct: 4121 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 4175

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
            +   S L    VS  D G Y C A N++G T A
Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 4208



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 82/266 (30%), Positives = 107/266 (40%), Gaps = 40/266 (15%)

Query: 89   VLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK--IVEISSDIS 146
            V+L     Q S+    +   D G Y C            V L V   P     E S  + 
Sbjct: 1158 VVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLE 1217

Query: 147  INEGNNISLTCIATGRPEPTVTWR--------HISPKAVGFVSEDEYLEIQGITREQSGD 198
               G N SL C A G P+P VTWR        H  P     V E+  L +  ++   SGD
Sbjct: 1218 RVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVA--VLEEGSLFLASVSPADSGD 1275

Query: 199  YECSASNDVAAPVVRRVKVTVNYPPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQ 254
            YEC A+N+V +   RR K+ V  PP I E    A  +G+  GQ  TL+C+A+  P  E  
Sbjct: 1276 YECQATNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIV 1333

Query: 255  WYKDDKRLIEGKKG----------VKVENRPFLSK---LIFFNVSEHDYGNYTCVASNKL 301
            W K D +L+    G           +V     L +   L F  + E D G Y+C A N+ 
Sbjct: 1334 WLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA 1392

Query: 302  GHTNASIML--------FGPGAVSEV 319
            G       L         G GA  EV
Sbjct: 1393 GTAQRDFHLLVLTPPSVLGAGAAQEV 1418



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 78/282 (27%), Positives = 112/282 (39%), Gaps = 34/282 (12%)

Query: 45  VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
           V V  GE A L C        RV W       Y G  +  L P         +   + I 
Sbjct: 707 VLVAVGEEAVLVCEASGVPPPRVIW-------YRGGLEMILAPE------GSSSGKLRIP 753

Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
                D G YTC    +    ++ + L V  +P++ E+  D+++  G +  L C ATGRP
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 813

Query: 164 EPTVTWRHISPKAVGF-----------VSEDEYLEIQGITREQSGDYECSASNDVA-APV 211
            PTVTWR    + +G              +   L  + +  E    Y C A N       
Sbjct: 814 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQA 873

Query: 212 VRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK-G 268
             R+ VT + PP I S A    V  GQ  +L C   A  P  E  W KD + L  G +  
Sbjct: 874 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 933

Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           ++ +    L + +     EH  G Y+CVA+N  G  +  + L
Sbjct: 934 IRADGSLHLDRAL----QEH-AGRYSCVATNTAGSQHRDVEL 970



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 11/226 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+ +  V V D G Y C+        + R  L VQV P++      + +  G  + L C+
Sbjct: 1083 SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCV 1142

Query: 159  ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
            A G PEP ++W        G   +   +    I    +G Y C ASN  A      V++ 
Sbjct: 1143 AEGNPEPQLSWSKDGVVLQGRGPQGS-VHFAAIRTSDAGRYRCEASNS-AGVDAWEVELR 1200

Query: 219  VNYPPYISEAKGTGV---PVGQKGTLQCEASAVPSAEFQWYK-DDKRLIEGKKGVKVENR 274
            V  PP+    + +G+     G+  +L C A   P  +  W K      + G+ GV V   
Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE 1260

Query: 275  PFLSKLIFFNVSEHDYGNYTCVASNKLGHTN--ASIMLFGPGAVSE 318
                 L   +VS  D G+Y C A+N++G T+  A ++++ P ++ E
Sbjct: 1261 ---GSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRE 1303



 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)

Query: 43   DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            D V VR G+ A L C  D      A    +   Y       L  R   L   Q    +EI
Sbjct: 3040 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 3090

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
            Q   V D+G Y+C V            L VQV P      ++ +S   G+ + LTC  +G
Sbjct: 3091 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 3150

Query: 162  RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
             P PTVTW      +   AV G VS    L++  +   Q+G Y C A N   A   +   
Sbjct: 3151 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 3209

Query: 217  VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V V   P I     A+   V  GQ+  L CEA   P  +  W KD   L +   G  +  
Sbjct: 3210 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 3268

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                  L+   +   D G YTCVA N  G
Sbjct: 3269 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 3297



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)

Query: 21   LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
            LL L P   PV  GD    + ++ VTV    + +L+C  + N V  ++WL          
Sbjct: 2836 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 2884

Query: 80   DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
              +   PR+ +L + Q    +++   +V D   Y C  +           L VQV P+I 
Sbjct: 2885 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 2940

Query: 140  EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
             +  + ++    +++SL C     P P VTW   S      + V  +     L++     
Sbjct: 2941 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 3000

Query: 194  EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
              SG Y C A N  A    + V+++V  PP   +A         V VG K  L CE  A+
Sbjct: 3001 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 3059

Query: 249  PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            P     WYKD + L+  ++   +       +L        D G Y+C  SN  G
Sbjct: 3060 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 3110



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            ++I+ VD+ DEG YTC+           V L V V P I     + ++ E  +++L C+A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909

Query: 160  TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            +G P P V+W    + +S      VS D   L I+      +G Y C ASN VA     R
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 1968

Query: 215  VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
              + VN PP I+       P  V     L C A+  PS    W KD   +   G  G++V
Sbjct: 1969 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 2028

Query: 272  ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
               P    L   +    D G Y+CVA + +G     ++L
Sbjct: 2029 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 2065



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)

Query: 45   VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            + V  G++A L C +      ++ W      L  G D   + P  VLL   Q   S    
Sbjct: 2455 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 2509

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
                   G Y+C        KT    L V ++P I+   E S+D  +++   N ISL C 
Sbjct: 2510 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 2564

Query: 159  ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
            A   P P +TW        + + +  +     L+I    +E +G Y C  +N++    V+
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 2623

Query: 214  RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
               V V  PP IS+         K     V    TL+CE+ AVP    +WYKD + +   
Sbjct: 2624 NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 2683

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             + ++V     L ++    VS  D G Y CVA+N  G
Sbjct: 2684 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 2717



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            ++EI        G YTCS +         V L VQ SP +  + S +       + L C 
Sbjct: 3911 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 3970

Query: 159  ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            A+G P PT+TW+    +++      V     L I   + E +G+Y C A N  A   + +
Sbjct: 3971 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 4029

Query: 215  VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
             ++ V  PP I           G    L C+A   P     W KD +  + G +G K   
Sbjct: 4030 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 4087

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +P   +L+  N+   D G YTC A N +G     + L
Sbjct: 4088 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 4123



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)

Query: 48   RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
            R GE  T+ C +  +    V+WL     L        L  R +L  +  T   + I  V 
Sbjct: 3326 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 3375

Query: 107  VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
            + D G +TC   +          L VQV P +  VE  +D+ +  G+ + L C A G P 
Sbjct: 3376 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435

Query: 165  PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            P V+W +   P     + +   L+++ +    SG Y C A ++ A    R  ++TV  PP
Sbjct: 3436 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 3494

Query: 224  YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
            +I ++       +  G    L C+A   P     W+KD + L       ++EN    +++
Sbjct: 3495 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 3548

Query: 281  IFFNVSEHDYGNYTCVASNKLG 302
            +       D G YTC+A +  G
Sbjct: 3549 L----RVRDAGLYTCLAESPAG 3566



 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 72/279 (25%), Positives = 110/279 (39%), Gaps = 23/279 (8%)

Query: 44   NVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS---- 99
            +VTV  G SA L C    R          T+ +   D   L  R+     ++++      
Sbjct: 794  DVTVELGRSALLACRATGRPP-------PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 846

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIV--QVSPKIVEISSDISINEGNNISLTC 157
            +  ++V   D+ PY C  +       +   LIV     P+I   +  + + EG  +SL C
Sbjct: 847  LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 906

Query: 158  IA-TGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
            I   GRP P   W    R + P +   +  D  L +    +E +G Y C A+N  A    
Sbjct: 907  IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN-TAGSQH 965

Query: 213  RRVKVTVNYPPYISEAKGTGVP-VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
            R V++ V  PP I       +   G   +L C AS VP+    W K+   L        V
Sbjct: 966  RDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV 1025

Query: 272  ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
                    L+    S  D G Y C A+N +G ++  + L
Sbjct: 1026 SKE---GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 1061



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
           S EI      +EG Y C+  +      ++  ++V   P  +  + +++++ G    L+C 
Sbjct: 480 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 539

Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
             G     +TW     + P + G V++  D  LEI GI     G Y+C ASN  A  V R
Sbjct: 540 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 597

Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
             V + V   P +S          G +  + C AS  P+    W ++ + L E  + + V
Sbjct: 598 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 656

Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
           + +     LI   V+  D GNY+C A+N++G    ++ L+   P +VS V+
Sbjct: 657 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 704



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)

Query: 42   MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
            + N+T       TL C  +      + W      +  G D + L     +L  TQTQ   
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 2416

Query: 101  EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
                    D G Y+C    +         + V V P I   ++   I + +G    L C 
Sbjct: 2417 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468

Query: 159  ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
             TG P+P +TW             HISP  V        L++       +G Y C A+N 
Sbjct: 2469 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 2521

Query: 207  VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            V     +  +++V   P I      S  +   V V    +L CEA A PS    W KD  
Sbjct: 2522 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580

Query: 261  RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
               E  + +++   P    L   N  + D G YTCV +N+LG    N  + +  P ++S+
Sbjct: 2581 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 2637



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)

Query: 82   WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
            W  D   +L  + +   S++++ V   D G Y+C   ++         L V   P I + 
Sbjct: 3440 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499

Query: 142  S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
               +++S+  G  + L C A G P+P +TW H   +A+  + E+     + +    +G Y
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 3557

Query: 200  ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
             C A +   A + +  +V V  PP I   +G     G+  GQ   L+C   A P+ +  W
Sbjct: 3558 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 3615

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
            ++D   L E       E   FL       +S  D G+Y+C A N  G T+ +  +     
Sbjct: 3616 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 3672

Query: 311  ----FGPGAVSEVSNGTS 324
                 GP AV+   N T+
Sbjct: 3673 PTIRSGPPAVNVSVNQTA 3690



 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D   + C V  +         + V V P I +  +D ++     + LTC +TG P PTV+
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889

Query: 169  W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            W      +  +  G+ VS    LEI       +G Y CSA N  A    + V +TV   P
Sbjct: 3890 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 3948

Query: 224  YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
             +         V ++   L CEAS +P     W K+    +    GV  +  P   +L  
Sbjct: 3949 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 4004

Query: 283  FNVSEHDYGNYTCVASNKLG 302
             + S  D GNY C+A N  G
Sbjct: 4005 AHASPEDAGNYLCIAKNSAG 4024



 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)

Query: 110  EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
            EG YTC         +  + L V V P+I    E  + +S+ +    +L C ATG+P PT
Sbjct: 2230 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 2289

Query: 167  VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
            VTW     + VG        ++ + L ++      +G Y C A N +A    R+ +++V 
Sbjct: 2290 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 2347

Query: 221  YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
             PP     +         +    TL CEA  +P    +W++ ++ +  G+    +     
Sbjct: 2348 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 2407

Query: 277  LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
            L         E D G Y+C+ASN+ G    N S+ +  P ++
Sbjct: 2408 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 2446



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)

Query: 79   NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
            N  W  D   +L ++T+  Y+     +++      D G YTC              L V 
Sbjct: 1533 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591

Query: 134  VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
            V P I         +    G  ++L C+A G P PT++W H              ++   
Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 1651

Query: 186  LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
            L ++      SG Y C AS+  A   V +  V V  PP +  A+G G     VGQ   L 
Sbjct: 1652 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 1710

Query: 243  CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            C+AS  P    QW ++  R  E   GV+V ++   + L   +V     G + C A+N+ G
Sbjct: 1711 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 1767

Query: 303  HTNASI 308
               A +
Sbjct: 1768 TAGAEV 1773



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 16/223 (7%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
            +++   DV+D G YTC             +L V V+P   +  S  +++ EG+  SL+C 
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 2185

Query: 159  ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
              G P P ++WR       G  +  +++   G           Q G Y C  SN V    
Sbjct: 2186 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 2244

Query: 212  VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
             + +++ V+ PP I+  +   T V V Q G  TL+C A+  P     W +D +  +  + 
Sbjct: 2245 SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 2303

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            G++++N+     L          G Y+CVA N  G       L
Sbjct: 2304 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 2344



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
            ++I  V   + G Y+C    +         L+V   P I+    E+  ++++N  + +SL
Sbjct: 2806 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 2865

Query: 156  TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
             C A G P PT++W       SP     V ED + L++       +  Y C A N  A  
Sbjct: 2866 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 2924

Query: 211  VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              +   + V  PP I+  + +     +    +L C+  A P+ E  WYKD + L     G
Sbjct: 2925 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 2981

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +V   P    L        D G YTC A N  G     + L
Sbjct: 2982 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 3023



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 63/251 (25%), Positives = 88/251 (35%), Gaps = 69/251 (27%)

Query: 111  GPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR 170
            G Y+C        +   V L+VQV P+I   ++    NEG   SL C+A+G P PT+TW 
Sbjct: 951  GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 1010

Query: 171  H-----------------------------------ISPKAVGFVSEDEYLEIQGITREQ 195
                                                 +   VGF S++  L +  +   +
Sbjct: 1011 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSK 1070

Query: 196  -----------------------SGDYECSASNDVAAPVVRRVKVTVNYPPYISEA-KGT 231
                                   SG YEC+ASN  A     R  + V  PP +    +  
Sbjct: 1071 YVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP-AGSASHRYVLGVQVPPQVQPGPRVL 1129

Query: 232  GVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYG 291
             V VG+   L C A   P  +  W KD         GV ++ R     + F  +   D G
Sbjct: 1130 KVLVGEALDLNCVAEGNPEPQLSWSKD---------GVVLQGRGPQGSVHFAAIRTSDAG 1180

Query: 292  NYTCVASNKLG 302
             Y C ASN  G
Sbjct: 1181 RYRCEASNSAG 1191



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 60/230 (26%), Positives = 93/230 (40%), Gaps = 30/230 (13%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS--SDISINEGNNISLT 156
            S+ + +V   D G Y C    +    + R  L+V V P I E    +++S   G +++L 
Sbjct: 1262 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 1321

Query: 157  CIATGRPEPTVTWRHISPKAVG---------------------FVSEDEYLEIQGITREQ 195
            C A G P P + W     + VG                      + E + L    I    
Sbjct: 1322 CDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGD 1380

Query: 196  SGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT---LQCEASAVPSAE 252
            SG Y C A N  A    R   + V  PP +  A      +G  G    LQC  S VP+ +
Sbjct: 1381 SGLYSCRAENQ-AGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ 1439

Query: 253  FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +W KD + ++ G   ++V+    + ++   +V   D G Y CVA +  G
Sbjct: 1440 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAG 1487



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)

Query: 88   VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
            +VL  +  TQ+      +++Q +   D G Y+C+ +      +    + +   P I    
Sbjct: 3620 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 3679

Query: 143  SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
              ++++      L C A G P P V+WR     + P++  F +  +  L IQ +  + +G
Sbjct: 3680 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 3739

Query: 198  DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
             Y C ASN   +    R    +  P          +       L CEAS  P     W+K
Sbjct: 3740 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 3799

Query: 258  D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
            D    D RL +G   +   N      L+       D   + CV SN++G  +
Sbjct: 3800 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 3846



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 37/238 (15%)

Query: 98   YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-------SDISINEG 150
            + ++I N    D G YTC V  +        H+ V + P I +          ++     
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654

Query: 151  NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
            + ++L C +   P PT+ W    + ++P + +  + E   L+IQ      SG Y C A+N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 206  DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
             VA    +   V +  PP                   EA+G       +       L C+
Sbjct: 2715 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773

Query: 245  ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +A+P  +  WY++D+ L  G +   ++    L   +   V   + G Y+C ASN++G
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 2828



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 11/210 (5%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D G Y+C   +        V L V + P I+    ++S+    +++L C +   P P ++
Sbjct: 2044 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103

Query: 169  W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            W    R + P+    +S D+  L++       +G Y C A N  A    +   + V   P
Sbjct: 2104 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVWVAP 2162

Query: 224  Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
               + E+    V  G   +L CE   VP  +  W KD + L    +G  +++   + +L+
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 2220

Query: 282  FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
            +   ++    G YTC  SN +G+++  + L
Sbjct: 2221 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 2250



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)

Query: 81   KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
            +W  D + VL      Q       + I    V DEG Y C   +    +     L V   
Sbjct: 1441 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 1500

Query: 136  PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
            P I     + ++++ E + + L C A G P P +TW         S K V +      L+
Sbjct: 1501 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 1559

Query: 188  IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
            +       +G Y C ASN V A   +  ++ V  PP I  A G    V    G+   L+C
Sbjct: 1560 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 1618

Query: 244  EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             A   PS    W+ +   + E  +  ++E     S L   +  E   G Y+CVAS+  G
Sbjct: 1619 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 1674



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)

Query: 25   VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
            VPT   +RSG    P A+ NV+V Q  +A L C  D      V+W           D+  
Sbjct: 3672 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 3712

Query: 84   LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
            LDPR         + S+ IQ V   D G Y C              L V   P I    S
Sbjct: 3713 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 3771

Query: 144  DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
            ++++       L C A+G P+P V W     K    + +  Y       L +     + S
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 3831

Query: 197  GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
              +EC  SN+V     R  +VTV+ PP I++ +    V +     L C ++ +P+    W
Sbjct: 3832 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 3890

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K   +L  G +G      P  +  I   +  H  G YTC A N  G  +  + L
Sbjct: 3891 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 3942



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 24/272 (8%)

Query: 46   TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            ++R G+   LRC      T R+ W          ND+    P    +S      +++   
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 4186

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
            V   D G Y C  + +   +T  V  + V+ +P +  E  S +    G +I L C+  G 
Sbjct: 4187 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 4245

Query: 163  PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
            P P + W      +    +    ++  L I    R+ +G Y+C A N++       + V 
Sbjct: 4246 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 4305

Query: 219  VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
             + P +  E +   V  G    L+C+A+  P+   +W +  + L   ++   + +     
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 4361

Query: 279  KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             L   NV   D G Y CVA N LG   A   L
Sbjct: 4362 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 4393



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 5/144 (3%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+ I   +  D G Y C  + +       V L++Q +P       D+++  G++++L C 
Sbjct: 4272 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 4331

Query: 159  ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            ATG P PT+ W                 D  L ++ +    +G Y+C A N + +   R 
Sbjct: 4332 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 4391

Query: 215  VKVTVNYPPYISEAKGTGVPVGQK 238
              V V   P  S    TGV  G+K
Sbjct: 4392 FLV-VRGEPQGSWGSMTGVINGRK 4414



 Score = 35.4 bits (80), Expect = 0.075
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)

Query: 17   VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
            V+ +++ LV    PV      F     ++TVR G+   LRC      T  + WL     L
Sbjct: 4296 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 4349

Query: 76   YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
             A                T    S+ ++NV+  D G Y C         T+R  L+V+  
Sbjct: 4350 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 4398

Query: 136  PK 137
            P+
Sbjct: 4399 PQ 4400


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score =  105 bits (263), Expect = 5e-23
 Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)

Query: 44  NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           NVTV  GE+A L C +       + W+    +L A         RV  L++     S+EI
Sbjct: 524 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 573

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
             +   D G Y C     N    + V L+V+ +P++   +S    ++G  + ++C A+G 
Sbjct: 574 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 633

Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
           P P ++W    + +   +   V     L IQG+  E +G+Y C A+N+V      +  VT
Sbjct: 634 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 690

Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           + Y  PP +S       V VG++  L CEAS VP     WY+    +I   +G       
Sbjct: 691 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 745

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              KL      E D G YTC A N+LG  +A I L
Sbjct: 746 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
           S EI      +EG Y C+  +      ++  ++V   P  +  + +++++ G    L+C 
Sbjct: 479 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 538

Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
             G     +TW     + P + G V++  D  LEI GI     G Y+C ASN  A  V R
Sbjct: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 596

Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
             V + V   P +S          G +  + C AS  P+    W ++ + L E  + + V
Sbjct: 597 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 655

Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
           + +     LI   V+  D GNY+C A+N++G    ++ L+   P +VS V+
Sbjct: 656 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 703


>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
          Length = 1349

 Score =  103 bits (258), Expect = 2e-22
 Identities = 84/282 (29%), Positives = 121/282 (42%), Gaps = 24/282 (8%)

Query: 45  VTVRQGESATLRCTIDNRVTR------VAWLNRST----ILYAGNDKWCLDPRVVLLSNT 94
           VT R GES  LRC + + VT       V W          +  G     +DP     ++ 
Sbjct: 33  VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92

Query: 95  QTQYSIEIQNVDVYDEGPYTCSV-----QTDNHPKTSRVHLIVQVSPKIVEISSD-ISIN 148
             + S+ ++ V   D+G Y C V     Q D     S VHL +   P   E     I   
Sbjct: 93  HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152

Query: 149 EGNNISLTCIATGRPEPTVTWRH---ISPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
           EG +I++TC A G P+P VTW     +   +  +   D  L +  ++RE  G Y C A +
Sbjct: 153 EGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYS 212

Query: 206 DVAAPVVRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASAVP-SAEFQWYKDDKRLI 263
            +    V    + V  PP+I S  +   V + Q   L C A A P +  + WY  D+  +
Sbjct: 213 -IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDEN-V 270

Query: 264 EGKKGVKVENRPFLS-KLIFFNVSEHDYGNYTCVASNKLGHT 304
             +  +K+  R  +   LI F V   D G YTCV SN LG +
Sbjct: 271 YFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRS 312



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 77/272 (28%), Positives = 107/272 (39%), Gaps = 30/272 (11%)

Query: 45  VTVRQGESATLRCT-IDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
           +  ++G S T+ CT   N    V WL   T+L A       D             S+ + 
Sbjct: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDG------------SLTVT 196

Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
           +V   D G YTC   +         HL+VQ  P IV    +I++N   +  LTC A   P
Sbjct: 197 SVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYP 256

Query: 164 -EPTVTWRHISPKAVGFVSE---------DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
              T TW +   + V F ++         D  L I  +  E SG Y C  SN +      
Sbjct: 257 GNLTYTW-YWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSA 315

Query: 214 RVKVTVNYPPYISEAKGT-GVPVGQKGTLQCEASAVPSAE-FQWYKDDKRL-IEGKKGVK 270
              +TV YP  +        VPVG  G ++C   A P A   +W KD + L +E   G  
Sbjct: 316 SAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWT 375

Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
           +        +     +E   G YTCV  N LG
Sbjct: 376 LMED---GSIRIEEATEEALGTYTCVPYNTLG 404



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 71/286 (24%), Positives = 112/286 (39%), Gaps = 36/286 (12%)

Query: 43  DNVTVRQGESATLRCTIDNRVTRVA--WLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
           +N+TV   + A L C  +     +   W  +   +Y  ND   L  RV +L +     ++
Sbjct: 236 ENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND---LKLRVRILIDG----TL 288

Query: 101 EIQNVDVYDEGPYTC--SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            I  V   D G YTC  S      P  S  +L VQ   +++ +   I +  G +  + C 
Sbjct: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSAS-AYLTVQYPARVLNMPPVIYVPVGIHGYIRCP 347

Query: 159 ATGRPEPTVT-WRHIS-----PKAVGF-VSEDEYLEIQGITREQSGDYECSASNDV---- 207
               P  TV  W          K +G+ + ED  + I+  T E  G Y C   N +    
Sbjct: 348 VDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMG 407

Query: 208 -AAPVVRRVKVTVNYPPYISEAKGTGV--PVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
            +AP     ++ +  PPY +   G       G++  + C A+  P     W K       
Sbjct: 408 QSAPA----RLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRK------V 457

Query: 265 GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           GK      +      L F  +S+ D+G + CVA+N +    AS  L
Sbjct: 458 GKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHL 503


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  103 bits (257), Expect = 2e-22
 Identities = 84/278 (30%), Positives = 123/278 (44%), Gaps = 35/278 (12%)

Query: 46   TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            TV +   A L C  D   T  + W   + +L     K+  +P   L+          ++N
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELI----------LEN 4228

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
            V + D G YTC         T  V L V V P   E+  D+S+N+G  + L+C ATG P 
Sbjct: 4229 VVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPL 4288

Query: 165  PTVTW---RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK-VTVN 220
            P +TW    +I P     V+    L I+ +++E SG Y C+A N V    V+ +  V V 
Sbjct: 4289 PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG--FVKAIGFVYVK 4346

Query: 221  YPPYISEAKGTG--VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
             PP       +    P+G    L CE    P+   QW          +KGV +E    + 
Sbjct: 4347 EPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQW---------NRKGVDIEISHRIR 4397

Query: 279  KL------IFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +L      I+  V+E D G+YTCVA+N+ G    S+ L
Sbjct: 4398 QLGNGSLAIYGTVNE-DAGDYTCVATNEAGVVERSMSL 4434



 Score =  102 bits (253), Expect = 7e-22
 Identities = 76/277 (27%), Positives = 116/277 (41%), Gaps = 25/277 (9%)

Query: 43  DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSN-----TQTQ 97
           +NVTV  GE A L C I + V               N  W  + R V L+      T   
Sbjct: 527 NNVTVTPGERAVLTCLIISAVDY-------------NLTWQRNDRDVRLAEPARIRTLAN 573

Query: 98  YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
            S+E+++V   D G Y C V ++     + V L VQ  PK+  +  + S   G+ +S+ C
Sbjct: 574 LSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMC 633

Query: 158 IATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
            ATG P+P + W       VG     ++ D  L I+    + +G Y C ASN        
Sbjct: 634 SATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693

Query: 214 RVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
                +  P  +       V +G    ++C+ S +P  + +W+K D   +E +    +  
Sbjct: 694 STLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGD---LELRPSTFLII 750

Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            P L  L      + D G+YTCVA N+ G     I L
Sbjct: 751 DPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITL 787



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 79/281 (28%), Positives = 123/281 (43%), Gaps = 34/281 (12%)

Query: 42   MDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
            +++V V++ +S TL C +  N V  + W      L         D    ++S  +    +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQE-------DEAHHIISGGRF---L 2535

Query: 101  EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-----ISINEGNNISL 155
            +I NV V   G YTC   +    K+    L V VSP I  + SD     +++   +  SL
Sbjct: 2536 QITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSL 2595

Query: 156  TCIATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
             C A   P  T+TW        S + +  +     L+I     + +G Y C A+N+ A  
Sbjct: 2596 VCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNE-AGE 2654

Query: 211  VVRRVKVTVNYPPYISEA---------KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
            +++  +V V  PP I++          K   + V    TL+CEA A+PSA   WYKD + 
Sbjct: 2655 MIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP 2714

Query: 262  LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            L +    V +       ++    +S  D G YTCVASN  G
Sbjct: 2715 L-KSDDHVNIAANGHTLQIKEAQIS--DTGRYTCVASNIAG 2752



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 78/279 (27%), Positives = 117/279 (41%), Gaps = 28/279 (10%)

Query: 45   VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            + V +G+S +L C +       V W+     L        LD   +L          +++
Sbjct: 2302 IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHIL----------QLK 2351

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIAT 160
            N+ V D G Y C           +  L V   P I+       +IS+ E N++SLTC A+
Sbjct: 2352 NIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEAS 2411

Query: 161  GRPEPTVTWRHIS-----PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRV 215
            G P P++TW           +V  +S    L +   T E +G Y C   N  AA   R++
Sbjct: 2412 GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN--AAGEERKI 2469

Query: 216  -KVTVNYPPYI---SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
              ++V  PP+I   +  +   V   Q  TL CE +  P  E  W+KD + L E +    +
Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII 2529

Query: 272  ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
                FL      NV     G YTC+AS+  GH + S  L
Sbjct: 2530 SGGRFLQ---ITNVQVPHTGRYTCLASSPAGHKSRSFSL 2565



 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 69/219 (31%), Positives = 98/219 (44%), Gaps = 13/219 (5%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            +IEI    +   G YTC  +         V L V   P I    S++ +   N I L C 
Sbjct: 3951 AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCE 4010

Query: 159  ATGRPEPTVTWRH--ISPKAVG---FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
            ATG P P +TW+   I+    G    V     L+I    RE +G Y C A N  A   + 
Sbjct: 4011 ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNP-AGTALG 4069

Query: 214  RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
            ++K+ V  PP IS   K   + V +  TL CEA  +P  +  W+KD + ++E      + 
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVE-----SIR 4124

Query: 273  NRPFLS-KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             R   S  L    V   D G+YTC+A+N  G ++ S  L
Sbjct: 4125 QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKL 4163



 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 81/295 (27%), Positives = 114/295 (38%), Gaps = 22/295 (7%)

Query: 23   FLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRV-AWLNRSTILYAGNDK 81
            +LV   VP        P+   ++TV +    TL C  D     V  WL     L A    
Sbjct: 3612 YLVRVHVPPNIAGTDEPR---DITVLRNRQVTLECKSDAVPPPVITWLRNGERLQA---- 3664

Query: 82   WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
                PRV +LS  +    ++I N D+ D   YTC         T    L V V P I   
Sbjct: 3665 ---TPRVRILSGGRY---LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGG 3718

Query: 142  SSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQS 196
               + I    +  L CIA G P P +TWR       G      + E+ +L IQ      +
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDT 3778

Query: 197  GDYECSASNDVAAPVVRRVKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQW 255
            G Y C A+N  A    RR+ + V+ PP I+       V V  + TL CEA+ +P     W
Sbjct: 3779 GRYLCMATN-AAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW 3837

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K+   L+   +            L+  + S  D   Y C  +N  G    ++ L
Sbjct: 3838 RKNG-HLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL 3891



 Score = 85.1 bits (209), Expect = 8e-17
 Identities = 63/234 (26%), Positives = 102/234 (43%), Gaps = 15/234 (6%)

Query: 82   WCLDPRVVLLSNTQ---TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI 138
            W  D R ++ S  Q   +  S++I  V   D G YTC         ++   L V V P+I
Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171

Query: 139  VEISSDISINEGNNISLTCIATGRPEPTVTWRH---ISPKAVGFVSEDEY--LEIQGITR 193
                   ++NE +   L C+A G P P + W+    +    +G  + + Y  L ++ +  
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL 4231

Query: 194  EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAE 252
            E SG Y C A N+ A      V +TV+  P  +E  G   +  G++  L C+A+ +P  +
Sbjct: 4232 EDSGFYTCVA-NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPK 4290

Query: 253  FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
              W  ++  +      V        S+L+   VS+ D G Y C A N +G   A
Sbjct: 4291 LTWTFNNNIIPAHFDSVNGH-----SELVIERVSKEDSGTYVCTAENSVGFVKA 4339



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 13/215 (6%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNNIS 154
            +++I    V D G YTC           +  L V V P I +  S+    +++ EG ++S
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVS 3078

Query: 155  LTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
            L C +   P P +TW    R I+    V  +++ + L I+      +G Y C A N VA 
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAG 3137

Query: 210  PVVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
               +   + V  PP I   E +     +    TL C+A+ +P     W K+ KR IE   
Sbjct: 3138 RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKR-IENSD 3196

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             ++V      SKL        D GNYTC+ASN  G
Sbjct: 3197 SLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 76/288 (26%), Positives = 121/288 (42%), Gaps = 47/288 (16%)

Query: 47   VRQGESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            V +G+  TL CT+   N +    W+  S +L         +P + + S+     S+ I+ 
Sbjct: 901  VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ-------NPYITVRSDG----SLHIER 949

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
            V + D G YTC              ++V V P I      +S  EG  ++L C A+G P+
Sbjct: 950  VQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPK 1009

Query: 165  PTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
            P+V W      IS  +  F    D  L +     E+SG+Y C+A+N  A    R+V++TV
Sbjct: 1010 PSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN-TAGYAKRKVQLTV 1068

Query: 220  NYPPYI-------SEAKGTGVPV--GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
               P +       S+ K   + V  G++ TL CE  ++P     W K+ + +        
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLI-------- 1120

Query: 271  VENRPFLSKLIFF--------NVSEHDYGNYTCVASNKLGHTNASIML 310
                PF  +  F              D G Y CVA+N  G+   ++ L
Sbjct: 1121 ---SPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKL 1165



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 37/292 (12%)

Query: 39   PKAMDN------VTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLL 91
            P  MDN      +TV +G S ++ C  D      +AWL     L        LD  + + 
Sbjct: 3433 PPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLG-------LDAHLTVS 3485

Query: 92   SNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINE 149
            ++      +++   +  D G YTC    +    +    L V   P I   E   +IS+  
Sbjct: 3486 THGMV---LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIV 3542

Query: 150  GNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSAS 204
             N + LTCIA+G P P +TW            V  +   E L I     E +G Y C AS
Sbjct: 3543 NNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602

Query: 205  NDVAAPVVRRVKVTVNYPPYIS---EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
            +  A    +   V V+ PP I+   E +   V   ++ TL+C++ AVP     W ++ +R
Sbjct: 3603 SP-AGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGER 3661

Query: 262  LIEGKKGVKVENRPFLSKLIFFNVSEHDYG---NYTCVASNKLGHTNASIML 310
            L +    V++     LS   +  ++  D G   NYTCVASN  G T    +L
Sbjct: 3662 L-QATPRVRI-----LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707



 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 75/292 (25%), Positives = 115/292 (39%), Gaps = 28/292 (9%)

Query: 23   FLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDK 81
            F +   VP       FP   + V+V       L C +       + W      L+ G   
Sbjct: 1444 FNIDVLVPPTIIGTNFP---NEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG--- 1497

Query: 82   WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV-- 139
               DP V LL   Q    + ++N    D+G Y C+V      +   + L + + P I   
Sbjct: 1498 ---DPNVELLDRGQV---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551

Query: 140  EISSDISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITRE 194
             +++DIS+   + I L C   G P P +TW       +S     ++ + +YL I      
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611

Query: 195  QSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT----GVPVGQKGTLQCEASAVPS 250
             S  Y C  +N VA    +   V V  PP I     T     V +    TL+C+A+  PS
Sbjct: 1612 DSATYTCHVAN-VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670

Query: 251  AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                W KD    ++    +++E      KL   +  E D G Y CVA++  G
Sbjct: 1671 PILTWLKDGVP-VKANDNIRIEAGG--KKLEIMSAQEIDRGQYICVATSVAG 1719



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 63/228 (27%), Positives = 103/228 (45%), Gaps = 17/228 (7%)

Query: 91   LSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISIN 148
            LS ++ +  ++I++  V D G YTC             ++ + V P I   +  + +++ 
Sbjct: 2150 LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVI 2209

Query: 149  EGNNISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEYLEIQGITREQSGDYEC 201
            EGN ISL C ++G P P + W+         S   V  +S    L+I    +  +  Y C
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSC 2269

Query: 202  SASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQCEASAVPSAEFQWYK 257
             ASN VA    +   + V   P I+ +      +    G+  +L+CE   +P     W K
Sbjct: 2270 VASN-VAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK 2328

Query: 258  DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
            D   LI+  KGV++ +   + +L   +VS  D G Y CVA N  G T+
Sbjct: 2329 DGHPLIKA-KGVEILDEGHILQLKNIHVS--DTGRYVCVAVNVAGMTD 2373



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 18/218 (8%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN-----EGNNI 153
            ++ I      D G YTC          + + L VQ  P + ++    +           I
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRI 1284

Query: 154  SLTCIATGRPEPTVTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDV 207
               C A G P+PT+ W H   +  G       + +   L I  +T   +G+Y C A N+ 
Sbjct: 1285 EFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE- 1343

Query: 208  AAPVVRRVKVTVNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
            A    R+  + V+ PP I + +      V + Q   L CE    PS    WYKD+ ++ E
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE 1403

Query: 265  GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                  V N   L     F  +  D G Y+C A N  G
Sbjct: 1404 SSTIQTVNNGKILK---LFRATPEDAGRYSCKAINIAG 1438



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 65/223 (29%), Positives = 93/223 (41%), Gaps = 26/223 (11%)

Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
           ++IQ     D G YTC    +    T ++ L V   P  ++  +D+S+  G+N++L C  
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV 816

Query: 160 TGRPEPTVTWRHIS-------PKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVA-A 209
            G PEPT+ WR +        P +V  +S+     L I  +     G Y C A N     
Sbjct: 817 QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKI 876

Query: 210 PVVRRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK 267
                V VT    P I  +     V  GQ+ TL C   A  P  E +W K+   L++   
Sbjct: 877 QSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ--- 933

Query: 268 GVKVENRPFLS-----KLIFFNVSEHDYGNYTCVASNKLGHTN 305
                  P+++      L    V   D G YTCVASN  G  N
Sbjct: 934 ------NPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN 970



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 17/235 (7%)

Query: 82   WCLDPRVVLLSNTQTQYS----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK 137
            W  D R++  S + T  +    I+I++  + D G Y C              L V V+P 
Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013

Query: 138  IVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGF------VSEDEYLEIQGI 191
            I   ++ +++   N + L C A G P P++TW         F      +S    L +   
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA 2073

Query: 192  TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASAVPS 250
                +G Y C A N  A    R + + V  PP I  E +   V + Q   L C++ A+P 
Sbjct: 2074 QISDTGRYTCVAVN-AAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132

Query: 251  AEFQWYKDDKRLIEGKKGVKV-ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
                W KD   L++ K G+ + ENR   S L   +    D G YTC A+N  G T
Sbjct: 2133 PTLTWLKDGHPLLK-KPGLSISENR---SVLKIEDAQVQDTGRYTCEATNVAGKT 2183



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 72/276 (26%), Positives = 112/276 (40%), Gaps = 23/276 (8%)

Query: 44   NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            ++ +   +S  L C  +   T R+ W     +L AGN       R  +L N      + I
Sbjct: 3721 SLVILLNKSTVLECIAEGVPTPRITWRKDGAVL-AGNHA-----RYSILENG----FLHI 3770

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
            Q+  V D G Y C           R+ L V V P I    +++++      +L C ATG 
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGI 3830

Query: 163  PEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQSGDYECSASNDVAAPVVRRV 215
            P+P++ WR          +++ Y       L I   + + +  YEC+ +N  A    R V
Sbjct: 3831 PKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNG-AGDDKRTV 3889

Query: 216  KVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR 274
             +TV  PP I+ E     V       + C AS VP     W K+  RL+    G ++ + 
Sbjct: 3890 DLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSS 3949

Query: 275  PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              +  L       +  G YTCVA N  G  +  + L
Sbjct: 3950 GAIEILA---TQLNHAGRYTCVARNAAGSAHRHVTL 3982



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 64/228 (28%), Positives = 99/228 (43%), Gaps = 19/228 (8%)

Query: 87   RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS--- 143
            RV +LS  +    ++I   +  D   Y+C             +L V + P I    S   
Sbjct: 2244 RVRILSGGR---QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300

Query: 144  DISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGD 198
            +I +  G +ISL C   G P PTVTW       I  K V  + E   L+++ I    +G 
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGR 2360

Query: 199  YECSASNDVAAPVVRRVKVTVNYPPYI--SEAKGTGVPVGQKG--TLQCEASAVPSAEFQ 254
            Y C A N VA    ++  ++V+ PP I  +      + V +K   +L CEAS +P     
Sbjct: 2361 YVCVAVN-VAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT 2419

Query: 255  WYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            W+KD    +     V++ +   + +L+    +  D G YTCV  N  G
Sbjct: 2420 WFKDGWP-VSLSNSVRILSGGRMLRLM--QTTMEDAGQYTCVVRNAAG 2464



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 63/220 (28%), Positives = 95/220 (43%), Gaps = 12/220 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTC 157
            +EI +    D G Y C   +    K  +  + V V P I   + +S   +   N + L C
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756

Query: 158  IATGRPEPTVTWR---HISPKAVGF--VSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
              TG P PT+ W     +  +  GF  +     L I       +G Y C A+N  A    
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAAN-TAGDHK 1815

Query: 213  RRVKVTVNYPPYI-SEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
            +  +VTV+ PP I S      V V  K   LQC A+ +P+    W KDD+ +   +  +K
Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK 1875

Query: 271  VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +++   + ++        D G YTCVA+N  G T   I L
Sbjct: 1876 IQSSGRVLQIA--KTLLEDAGRYTCVATNAAGETQQHIQL 1913



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 37/278 (13%)

Query: 45   VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            ++V  GE  TL C + +    +    + T L +        PR   L +     S++I  
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISP-----FSPRHTFLPSG----SMKITE 1139

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
                D G Y C         T  V L V V PKI      + +  G  + + C A G P 
Sbjct: 1140 TRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199

Query: 165  PTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
            P +TW             H+S       + D  L I   T   +G Y C A+N +A    
Sbjct: 1200 PVITWSKGGSTMLVDGEHHVS-------NPDGTLSIDQATPSDAGIYTCVATN-IAGTDE 1251

Query: 213  RRVKVTVNYPPYISEAKG------TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
              + + V  PP + + +             Q+    C A   P    +W  + + L   +
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311

Query: 267  KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
             G+ +     L  L+  +V+ +D G Y CVA N+ G T
Sbjct: 1312 PGISILEDGTL--LVIASVTPYDNGEYICVAVNEAGTT 1347



 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 57/219 (26%), Positives = 92/219 (42%), Gaps = 11/219 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS--INEGNNISLTC 157
            ++I    + D G YTC            + L V   P + +    ++  +   N + L C
Sbjct: 1883 LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942

Query: 158  IATGRPEPTVTW----RHIS-PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
             A G P P +TW    R +S   ++ F++  + ++I+      +G Y+C A N   A  +
Sbjct: 1943 KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATEL 2002

Query: 213  RRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
                + V+  P IS +     V V     L+CEA  +P+    W KD   +     G++V
Sbjct: 2003 -FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQV 2061

Query: 272  ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +   +  L    +S  D G YTCVA N  G     I L
Sbjct: 2062 LSGGRILALTSAQIS--DTGRYTCVAVNAAGEKQRDIDL 2098



 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 71/281 (25%), Positives = 116/281 (41%), Gaps = 28/281 (9%)

Query: 43   DNVTVRQGESATLRC-TIDNRVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
            + VTV   +SA + C +  +   R +W  +   +L   + K+  + R++ + NTQ     
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQ----- 2934

Query: 101  EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIA 159
                  + D G Y C  +          +L V V P ++   S+ +++   N ISLTC  
Sbjct: 2935 ------ITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988

Query: 160  TGRPEPTVTW-RHISPKAVG----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            +G P P ++W ++  P  +      V     L+I        G+Y C A N  A    ++
Sbjct: 2989 SGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQ-AGESKKK 3047

Query: 215  VKVTVNYPPYISEAKGTGVPV-----GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
              +TV  PP I +     + V     G   +L+CE++AVP     WYK+ + + E     
Sbjct: 3048 FSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITE---ST 3104

Query: 270  KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             VE       L        D G Y C A N  G  + +  L
Sbjct: 3105 HVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 61/217 (28%), Positives = 87/217 (40%), Gaps = 20/217 (9%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE----ISSD----ISINEGNNISLTCIAT 160
            + G Y C+          +V L V V P++      +S D    IS+  G  ++L C   
Sbjct: 1045 ESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104

Query: 161  GRPEPTVTWRHISPKAVGFVSEDEYL-----EIQGITREQSGDYECSASNDVAAPVVRRV 215
              P P +TW   +     F     +L     +I       SG Y C A+N +A  V + V
Sbjct: 1105 SLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN-IAGNVTQAV 1163

Query: 216  KVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR-LIEGKKGVKVEN 273
            K+ V+ PP I    K   V VGQ+  + C A   P     W K     L++G+  V   +
Sbjct: 1164 KLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD 1223

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
                  L     +  D G YTCVA+N  G     I L
Sbjct: 1224 ----GTLSIDQATPSDAGIYTCVATNIAGTDETEITL 1256



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 62/220 (28%), Positives = 90/220 (40%), Gaps = 19/220 (8%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEPT 166
            D G YTC              L +QV P +   EI SD+S+  G N+ L C A G P P 
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL 3277

Query: 167  VTW-RHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
            + W +   P A G        +    L I G     +G Y C A+N  A    R   + V
Sbjct: 3278 IQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNP-AGEEDRIFNLNV 3336

Query: 220  NYPPYI----SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
               P I     EA+     V     ++C A+  P  +  W K+   L      +++    
Sbjct: 3337 YVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPL-PLSSHIRLLAAG 3395

Query: 276  FLSKLIFFNVSEHDYGNYTCVASNKLGHTNA--SIMLFGP 313
             + +++   VS  D   YTCVASN+ G  N   ++ +F P
Sbjct: 3396 QVIRIVRAQVS--DVAVYTCVASNRAGVDNKHYNLQVFAP 3433



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 58/211 (27%), Positives = 88/211 (41%), Gaps = 10/211 (4%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            + + +  + D G YTC        K   + L V V P I+    ++S+     + L C +
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQS 2127

Query: 160  TGRPEPTVTW---RHISPKAVGF-VSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
               P PT+TW    H   K  G  +SE+   L+I+    + +G Y C A+N VA    + 
Sbjct: 2128 DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN-VAGKTEKN 2186

Query: 215  VKVTVNYPPYI---SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
              V +  PP I    E     V  G   +L CE+S +P     W K    ++    G +V
Sbjct: 2187 YNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG-RV 2245

Query: 272  ENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                   +L      + D   Y+CVASN  G
Sbjct: 2246 RILSGGRQLQISIAEKSDAALYSCVASNVAG 2276



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 14/212 (6%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
           +++I  V + DEG Y C   +      ++    V   P ++++ +++++  G    LTC+
Sbjct: 483 NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCL 542

Query: 159 ATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 211
                +  +TW       R   P  +  ++ +  LE++ +    +G+Y C  S++  +  
Sbjct: 543 IISAVDYNLTWQRNDRDVRLAEPARIRTLA-NLSLELKSVKFNDAGEYHCMVSSEGGSSA 601

Query: 212 VRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
              V +TV  PP ++   K      G + ++ C A+  P  +  W  +D  ++   +   
Sbjct: 602 A-SVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRM 660

Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +      L   N +  D G Y C+ASN  G
Sbjct: 661 TSD----GTLFIKNAAPKDAGIYGCLASNSAG 688



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 58/227 (25%), Positives = 91/227 (40%), Gaps = 16/227 (7%)

Query: 102 IQNVDVYDEGPYTC----SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
           I+N    D G Y C    S  TD    T R       +PK++ + S++ +  G+   + C
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI----EAPKLMVVQSELLVALGDITVMEC 723

Query: 158 IATGRPEPTVTW--RHISPKAVGFVSEDEYLEIQGITREQ---SGDYECSASNDVAAPVV 212
             +G P P V W    +  +   F+  D  L +  I   Q   +GDY C A N+ A    
Sbjct: 724 KTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINE-AGRAT 782

Query: 213 RRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK-GVK 270
            ++ + V  PP +I E     + +G   TL C     P    +W + D   I  +   V 
Sbjct: 783 GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVS 842

Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
             ++     L   N+   D G Y C A N+ G   +   +   G V+
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVA 889



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 17/232 (7%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNNISL 155
            ++I    V D G YTC    +    + +  + V V P I   +SD    +++    +  +
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892

Query: 156  TCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
             C+++G P P  +W+      +      F+S    L+I        G Y C A N  A  
Sbjct: 2893 ECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAEN-TAGS 2951

Query: 211  VVRRVKVTVNYPPYI--SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              +   + V+ PP +   +++   V V    +L CE S  P  +  W K+++ +   K  
Sbjct: 2952 AKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPI---KLN 3008

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA--SIMLFGPGAVSE 318
                  P    L        D G YTC+A N+ G +    S+ ++ P ++ +
Sbjct: 3009 TNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKD 3060



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 55/230 (23%), Positives = 83/230 (36%), Gaps = 30/230 (13%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE--------ISSDISINEG 150
            +++I N    + G Y+C    +         + V + P I +           ++ I   
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689

Query: 151  NNISLTCIATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
            N ++L C A   P  +++W        S   V   +    L+I+      +G Y C ASN
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN 2749

Query: 206  DVAAPVVRRVKVTVNYPPYISEAKGTG--VPVGQKG-----------TLQCEASAVPSAE 252
             +A        V +  PP   +    G  +  G+ G           +L CE +A P   
Sbjct: 2750 -IAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPT 2808

Query: 253  FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
              WYKD   L       KV   P    L        D G YTCVA N+ G
Sbjct: 2809 LTWYKDGHPLTSSD---KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 14/168 (8%)

Query: 50   GESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
            G +A L C +    T     NR  +         +  R+  L N     S+ I      D
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIE------ISHRIRQLGNG----SLAIYGTVNED 4413

Query: 110  EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
             G YTC    +       + L +Q  P I     +  IN G  I L C ATG P+PT+TW
Sbjct: 4414 AGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473

Query: 170  ----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
                  IS      V  +  L I    +E + ++EC A N + + +VR
Sbjct: 4474 SRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVR 4521


>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
           sapiens]
          Length = 848

 Score =  102 bits (255), Expect = 4e-22
 Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 28/284 (9%)

Query: 44  NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           N T   G+S TL C  +      ++W      +    D    D + +   ++     + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
           + VD  DE  Y C  +     + + +HL V   PKI  + +  ++     ++LTC A+G 
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334

Query: 163 PEPTVTWR---------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
           P P++TWR               H+  ++   VS    L ++ I    +G+Y C+ASN +
Sbjct: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS---LTLKSIQYTDAGEYICTASNTI 391

Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK- 266
                + + + V Y P +          G +  + CE  A PSA   W++D + L     
Sbjct: 392 GQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450

Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +K+ N P  S L     SE+D+GNY C A N++G  +   +L
Sbjct: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)

Query: 50  GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
           GES    C +  D +   ++W + +      N +     R+ ++ N  +  ++ I N ++
Sbjct: 34  GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88

Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
            D G Y C V T      S   + V++  K++     +     EG +  + C       P
Sbjct: 89  DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147

Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
           T+ W+H     I  K V F V  + YL+I+GI +   G Y C         +  + ++V 
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207

Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           VN PP I   +        +GQ  TL C+A   P     W KD +++ + +   K     
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
             S+L    V ++D   Y C+A NK G  +A+I L  F    ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 54/245 (22%), Positives = 100/245 (40%), Gaps = 38/245 (15%)

Query: 51  ESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
           E  TL C    + +  + W  R++     +++  LD  +V+ S+ +   S+ ++++   D
Sbjct: 323 EQVTLTCEASGDPIPSITW--RTSTRNISSEEKTLDGHMVVRSHARVS-SLTLKSIQYTD 379

Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN--EGNNISLTCIATGRPEPTV 167
            G Y C+        +  ++L VQ +PK+      +++   EGN +++TC     P  T+
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATI 436

Query: 168 TW---------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
           +W          + S   +       YLE+   +    G+Y C+A N +    +  + V 
Sbjct: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496

Query: 219 VNYP---------PYIS---------EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            + P         PY S         EA G GVP+  K   +  A        +WY   +
Sbjct: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVPI-LKYKAEWRAVGEEVWHSKWYDAKE 554

Query: 261 RLIEG 265
             +EG
Sbjct: 555 ASMEG 559


>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
           sapiens]
          Length = 761

 Score =  102 bits (255), Expect = 4e-22
 Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 28/284 (9%)

Query: 44  NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           N T   G+S TL C  +      ++W      +    D    D + +   ++     + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
           + VD  DE  Y C  +     + + +HL V   PKI  + +  ++     ++LTC A+G 
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334

Query: 163 PEPTVTWR---------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
           P P++TWR               H+  ++   VS    L ++ I    +G+Y C+ASN +
Sbjct: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS---LTLKSIQYTDAGEYICTASNTI 391

Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK- 266
                + + + V Y P +          G +  + CE  A PSA   W++D + L     
Sbjct: 392 GQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450

Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +K+ N P  S L     SE+D+GNY C A N++G  +   +L
Sbjct: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)

Query: 50  GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
           GES    C +  D +   ++W + +      N +     R+ ++ N  +  ++ I N ++
Sbjct: 34  GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88

Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
            D G Y C V T      S   + V++  K++     +     EG +  + C       P
Sbjct: 89  DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147

Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
           T+ W+H     I  K V F V  + YL+I+GI +   G Y C         +  + ++V 
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207

Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           VN PP I   +        +GQ  TL C+A   P     W KD +++ + +   K     
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
             S+L    V ++D   Y C+A NK G  +A+I L  F    ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 54/245 (22%), Positives = 100/245 (40%), Gaps = 38/245 (15%)

Query: 51  ESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
           E  TL C    + +  + W  R++     +++  LD  +V+ S+ +   S+ ++++   D
Sbjct: 323 EQVTLTCEASGDPIPSITW--RTSTRNISSEEKTLDGHMVVRSHARVS-SLTLKSIQYTD 379

Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN--EGNNISLTCIATGRPEPTV 167
            G Y C+        +  ++L VQ +PK+      +++   EGN +++TC     P  T+
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATI 436

Query: 168 TW---------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
           +W          + S   +       YLE+   +    G+Y C+A N +    +  + V 
Sbjct: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496

Query: 219 VNYP---------PYIS---------EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            + P         PY S         EA G GVP+  K   +  A        +WY   +
Sbjct: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVPI-LKYKAEWRAVGEEVWHSKWYDAKE 554

Query: 261 RLIEG 265
             +EG
Sbjct: 555 ASMEG 559


>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
           sapiens]
          Length = 858

 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 73/291 (25%), Positives = 123/291 (42%), Gaps = 32/291 (10%)

Query: 44  NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           N T   G+S TL C  +      ++W      +    D    D + +   ++     + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
           + VD  DE  Y C  +     + + +HL V   PKI  + +  ++     ++LTC A+G 
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334

Query: 163 PEPTVTW----RHISPKAVGFVSEDE------------------YLEIQGITREQSGDYE 200
           P P++TW    R+IS +     +  E                   L ++ I    +G+Y 
Sbjct: 335 PIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394

Query: 201 CSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
           C+ASN +     + + + V Y P +          G +  + CE  A PSA   W++D +
Sbjct: 395 CTASNTIGQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 453

Query: 261 RLIEGK-KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            L       +K+ N P  S L     SE+D+GNY C A N++G  +   +L
Sbjct: 454 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)

Query: 50  GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
           GES    C +  D +   ++W + +      N +     R+ ++ N  +  ++ I N ++
Sbjct: 34  GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88

Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
            D G Y C V T      S   + V++  K++     +     EG +  + C       P
Sbjct: 89  DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147

Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
           T+ W+H     I  K V F V  + YL+I+GI +   G Y C         +  + ++V 
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207

Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
           VN PP I   +        +GQ  TL C+A   P     W KD +++ + +   K     
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267

Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
             S+L    V ++D   Y C+A NK G  +A+I L  F    ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 48/211 (22%), Positives = 86/211 (40%), Gaps = 35/211 (16%)

Query: 84  LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
           LD  +V+ S+ +   S+ ++++   D G Y C+        +  ++L VQ +PK+     
Sbjct: 365 LDGHMVVRSHARVS-SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QG 420

Query: 144 DISIN--EGNNISLTCIATGRPEPTVTW---------RHISPKAVGFVSEDEYLEIQGIT 192
            +++   EGN +++TC     P  T++W          + S   +       YLE+   +
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480

Query: 193 REQSGDYECSASNDVAAPVVRRVKVTVNYP---------PYIS---------EAKGTGVP 234
               G+Y C+A N +    +  + V  + P         PY S         EA G GVP
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVP 539

Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
           +  K   +  A        +WY   +  +EG
Sbjct: 540 I-LKYKAEWRAVGEEVWHSKWYDAKEASMEG 569


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 17/282 (6%)

Query: 37   TFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
            +F +  D + V  G + T    +       V+W   S+ L  G      D   V L ++ 
Sbjct: 7776 SFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPG------DRCNVSLEDSV 7829

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
             +  +E+ +VD    G YTC V  +    +   HL ++   K V+  +D SI +G  + L
Sbjct: 7830 AE--LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLIL 7887

Query: 156  TCIATGRPEPTVTWR----HISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
                TG P  +VTW+    +++P     +    +   LEI   T E +G Y C   N   
Sbjct: 7888 EGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASG 7947

Query: 209  APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
                    + +  P ++ + +   V VG   +LQC+ +  P     WYK D +L      
Sbjct: 7948 KDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKL-RPTTT 8006

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K+  R  ++ L+F  V  +D G Y C A N +G  +AS  L
Sbjct: 8007 YKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFL 8048



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 79/274 (28%), Positives = 115/274 (41%), Gaps = 20/274 (7%)

Query: 44   NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            ++ V  GESA   C +   +  R+ W   +  +  G +       +  + NT     + I
Sbjct: 6279 SIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNY-----TITCVGNTP---HLRI 6330

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCIATG 161
              V   D G YTC    D         L V+  PK V+ + +     +G +I L C  +G
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISG 6390

Query: 162  RPEPTVTW------RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
             PE  V+W       H S K  + F++    L I   + E SGDY C A N V       
Sbjct: 6391 SPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCST 6450

Query: 215  VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
              +TV  PP  ++     G   G    LQCE S  P  E  W KD K++   KK  K+ +
Sbjct: 6451 A-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKK-FKITS 6508

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
            + F + L   N+   D G Y C A+N++G    S
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCS 6542



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 61/217 (28%), Positives = 98/217 (45%), Gaps = 21/217 (9%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCI 158
            + + +VD    G YTC V  D    +    L+V   PK V+ + +   +  G++  L C 
Sbjct: 5387 LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECK 5446

Query: 159  ATGRPEPTVTW---RHISPKA----VGFVSEDEYLEIQGITREQSGDYECSASNDVAAP- 210
              G PE  V W    H  P +    + F+     +++  ++ E SGD+ C A N   +  
Sbjct: 5447 IAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTS 5506

Query: 211  -----VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
                 +V+   V  ++PP +   K   V      +L+CE S  P  E  WYKD ++L   
Sbjct: 5507 CSTKVIVKEPPVFSSFPPIVETLKNAEV------SLECELSGTPPFEVVWYKDKRQLRSS 5560

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            KK  K+ ++ F + +   NV   D G Y C A N++G
Sbjct: 5561 KK-YKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG 5596



 Score = 92.0 bits (227), Expect = 7e-19
 Identities = 72/275 (26%), Positives = 113/275 (41%), Gaps = 20/275 (7%)

Query: 38   FPKAMDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAGND-KWCLDPRVVLLSNTQ 95
            F K ++ V     +   L C +D +R   V W      L  G D K C + ++  L    
Sbjct: 3646 FIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATL---- 3701

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNIS 154
                 EI    + D G Y C+   +    +    + V+  P  V+ +     +  G +  
Sbjct: 3702 -----EIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESAR 3756

Query: 155  LTCIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
            L C   G P   VTW    + +S      + FV+ +  L+I  +  E SG Y C A NDV
Sbjct: 3757 LHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDV 3816

Query: 208  AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
             +       V    P +I   +   +  G    LQCE S     E  W+KD K++   KK
Sbjct: 3817 GSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKK 3876

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
              ++ ++  L  L  F+ +  D G Y CV +N++G
Sbjct: 3877 -YRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 57/214 (26%), Positives = 95/214 (44%), Gaps = 8/214 (3%)

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
            T   +E+ N+D+   G YTC V  +    +    L V+     ++  SD S+  G +I L
Sbjct: 5946 TVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIIL 6005

Query: 156  TCIATGRPEPTVTWRH-----ISPKAVGFVSEDE--YLEIQGITREQSGDYECSASNDVA 208
                TG    +VTW+       + +    V+ ++   LEI   T+  +G Y C   N+  
Sbjct: 6006 ESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065

Query: 209  APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              V   +  T+  P +++E +     VG   +LQC+ +  P     WYK D +L      
Sbjct: 6066 RDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKL-RPTPE 6124

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +      ++ L+F  V+ +D G YTC A N +G
Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 71/282 (25%), Positives = 114/282 (40%), Gaps = 17/282 (6%)

Query: 37   TFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
            +F +  D+V V  G S T    I      +V W   S  L  G    C     + L +  
Sbjct: 6835 SFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGES--CN----ISLEDFV 6888

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
            T+  +E+  V   + G Y+C V  D    +   HL V+     V+  +D S+  G+ I L
Sbjct: 6889 TE--LELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVL 6946

Query: 156  TCIATGRPEPTVTWRH----ISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
                TG P  +V+W      IS     ++    +   LEI   T E    Y C   N+  
Sbjct: 6947 EATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAG 7006

Query: 209  APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              +   +   +  P +I   +     +G+  TLQC+    P     WYK+  +L      
Sbjct: 7007 QDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL-RSAPA 7065

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K++ +  ++ L+   V   D G Y+C A N +G   +S +L
Sbjct: 7066 YKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL 7107



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 73/275 (26%), Positives = 108/275 (39%), Gaps = 32/275 (11%)

Query: 44   NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            +V +  GES T +C +      ++ W   +  +  G +      ++ L+ NT T   + +
Sbjct: 7220 SVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNY-----KMTLVENTAT---LTV 7271

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCIATG 161
              V   D G YTC         +    L VQ  P+ ++ +     + +       C   G
Sbjct: 7272 LKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGG 7331

Query: 162  RPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
             PE  V W       +  S   + FV     LE+  ++ E SGDY C A N  A      
Sbjct: 7332 SPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHN-AAGSASSS 7390

Query: 215  VKVTVNYPPY-------ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
              + V  PP        I   KG  V       L+CE    P     WYKD + L  GKK
Sbjct: 7391 TSLKVKEPPIFRKKPHPIETLKGADV------HLECELQGTPPFHVSWYKDKRELRSGKK 7444

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
              K+ +  FL+ +   NV   D G Y C A+N +G
Sbjct: 7445 -YKIMSENFLTSIHILNVDAADIGEYQCKATNDVG 7478



 Score = 85.1 bits (209), Expect = 8e-17
 Identities = 63/241 (26%), Positives = 101/241 (41%), Gaps = 14/241 (5%)

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI-NEGNNIS 154
            T  S+E+      D G Y C +  D    TS+  L V+  P+ ++  S + +   G + +
Sbjct: 4821 TSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTT 4880

Query: 155  LTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
              C  TG P+  V+W         I    + F+      +I G   E SG Y C A ND 
Sbjct: 4881 FECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARND- 4939

Query: 208  AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
            A      +++ V  PP +I E K   V       L+CE +  P  E  W K+++ +   K
Sbjct: 4940 AGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSK 4999

Query: 267  KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---GPGAVSEVSNGT 323
            K   + +R  +  L        D G Y C+ SN+ G  + S  +     P  + ++ N T
Sbjct: 5000 K-YTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT 5058

Query: 324  S 324
            +
Sbjct: 5059 T 5059



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 73/286 (25%), Positives = 123/286 (43%), Gaps = 22/286 (7%)

Query: 37   TFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
            +F K ++N T     SAT + T+  +    + WL    IL   ++        V +S   
Sbjct: 5049 SFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDN--------VYISFVD 5100

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
            +  +++I++VD    G YTC  + ++  +     L+VQ   +IVE +  + + E + ++L
Sbjct: 5101 SVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTL 5160

Query: 156  TCIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDV- 207
             C+  G PE  V W    + I P    ++ F +      IQ + ++ SG Y     ND  
Sbjct: 5161 ECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220

Query: 208  --AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
              +     RV +  N PP +  +       +G    ++C+ S       QW+KD K +  
Sbjct: 5221 SSSCDAYLRV-LDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIST 5279

Query: 265  GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              K   V +   +S L   N+   D  NYTC  SN  G    S +L
Sbjct: 5280 SAKYRLVCHERSVS-LEVNNLELEDTANYTCKVSNVAGDDACSGIL 5324



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 63/284 (22%), Positives = 115/284 (40%), Gaps = 19/284 (6%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
            F   ++++TV  GE A L+ +I+  +   V WL     +   ++    + R+  + N  T
Sbjct: 5612 FVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESE----NIRITFVENVAT 5667

Query: 97   QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLT 156
               ++    +  + G Y C ++ D   + +   L+V     IVE +  +++  G   +L 
Sbjct: 5668 ---LQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLE 5724

Query: 157  CIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV-- 207
            C   G PE +V W                F ++   L I  + R+ +G Y     N+V  
Sbjct: 5725 CKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784

Query: 208  -AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
             +   V  V      P +    K TG  +G    L+C+ +        W+ +  +++ G 
Sbjct: 5785 SSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGA 5844

Query: 267  KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            K  +      +  L   ++   D GNYTCVA+N  G      +L
Sbjct: 5845 K-YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL 5887



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 60/241 (24%), Positives = 94/241 (39%), Gaps = 12/241 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTC 157
            S+E+  V   D G YTC V           +L V+     VE +     + +G+   L C
Sbjct: 4262 SLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLAC 4321

Query: 158  IATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
              TG P   +TW       +  S   + FV     L +  +  E SG+Y C A N+  + 
Sbjct: 4322 KVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSD 4381

Query: 211  VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
                + +    P +  E K   V       L  E +  P  E  W+KD+  L  G+K  K
Sbjct: 4382 HCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRK-YK 4440

Query: 271  VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---GPGAVSEVSNGTSRRA 327
               +  L  L        D G Y C  +N++G +  S  +     P  + ++ + +S R 
Sbjct: 4441 TFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRG 4500

Query: 328  G 328
            G
Sbjct: 4501 G 4501



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 65/288 (22%), Positives = 116/288 (40%), Gaps = 27/288 (9%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDN-RVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQ 95
            F K + + +   G++  LR  ++  +   V WL +R  ++    +      R+  + N  
Sbjct: 6553 FVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENT-----RISFIDNIA 6607

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
            T   +++ + +  + G Y C ++ D   +     L V    +I+E    +++  GN  +L
Sbjct: 6608 T---LQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFAL 6664

Query: 156  TCIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
             C+ TG PE +  W    R +S  +   + F+++   L+I        G Y     N V 
Sbjct: 6665 ECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVG 6724

Query: 209  ---APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
                 V   V   +  P +I + K     +G    L+C  S        W++D   ++ G
Sbjct: 6725 KSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSG 6784

Query: 266  KKGVKVENRPFLSKLIFFNVS---EHDYGNYTCVASNKLGHTNASIML 310
             K        F   +   N+S     D G YTCVA+N  G    S +L
Sbjct: 6785 PKC----QSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVL 6828



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 70/289 (24%), Positives = 112/289 (38%), Gaps = 27/289 (9%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
            F + +++V    GE ATL+C +D     R++W    T L +             +     
Sbjct: 7022 FIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAP--------AYKMQFKNN 7073

Query: 97   QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNNI 153
              S+ I  VD  D G Y+C          S   L+++   + P       D+    G  +
Sbjct: 7074 VASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPV 7133

Query: 154  SLTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
            +  C   G     V+W       +  +     FV     L+I    +   G Y CSASN 
Sbjct: 7134 AFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNP 7193

Query: 207  V--AAPVVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI 263
            +  A+   + +      PP+   +     + +G+ GT +C  +     +  W KD++ + 
Sbjct: 7194 LGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIR 7253

Query: 264  EGK--KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             G   K   VEN   L+ L    V + D G YTC ASN  G  + S  L
Sbjct: 7254 PGGNYKMTLVENTATLTVL---KVGKGDAGQYTCYASNIAGKDSCSAQL 7299



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 68/279 (24%), Positives = 110/279 (39%), Gaps = 22/279 (7%)

Query: 45   VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            +TV  GE+ TL C       +VA     ++ +  + K     +    S      S+ I +
Sbjct: 5713 MTVTVGETCTLEC-------KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILS 5765

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI-NEGNNISLTCI----A 159
            V+  D G YT  VQ  N+   S    +V VS + V  S    + N G  +  +CI     
Sbjct: 5766 VERQDAGTYTFQVQ--NNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKV 5823

Query: 160  TGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
             G    +V W H   K V        F      L++  +     G+Y C A+N   +   
Sbjct: 5824 AGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883

Query: 213  RRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
            R V      P ++ E +   V  G+  T        P  +  W++  + L++G +   + 
Sbjct: 5884 RAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDR-CNIY 5942

Query: 273  NRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
                +++L  FN+     G YTCV SN  G  + +  LF
Sbjct: 5943 FEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLF 5981



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 55/218 (25%), Positives = 88/218 (40%), Gaps = 10/218 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS--PKIVEISSDISINEGNNISLT 156
            S+EI    V D G YTC    +    +    L V  +  P  +     ++   G      
Sbjct: 3512 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFI 3571

Query: 157  CIATGRPEPTVTWRH----ISPKAVGFVSEDE---YLEIQGITREQSGDYECSASNDVAA 209
            C  TG P     W+     +SP     +S+ E    LE+  +T +  G Y C ASN   A
Sbjct: 3572 CTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631

Query: 210  PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
             + +   + ++ P +I E +     + +K  L+C+          W KD ++L  G K  
Sbjct: 3632 DICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPG-KDY 3690

Query: 270  KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
            K+     ++ L        D G Y C ASN+ G ++ S
Sbjct: 3691 KICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCS 3728



 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 56/222 (25%), Positives = 82/222 (36%), Gaps = 15/222 (6%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            +EI  ++  D G YTCS            HL V+  P  VE      +N    + L  + 
Sbjct: 4732 LEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALV 4791

Query: 160  TGRPEPTVTW----RHISPKAVGFVSEDE---YLEIQGITREQSGDYECSASNDVAAPVV 212
             G    T+ W    + +   A   V +D+    LE+       SG Y C  SNDV     
Sbjct: 4792 GGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATS 4851

Query: 213  RRVKVTVNYPPYISEAKGTGV-PVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
            +        P +I +     V   GQ  T +C+ +  P     WY D   +      ++ 
Sbjct: 4852 KATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEI----TAIQK 4907

Query: 272  ENRPFLSKLIFFNVS---EHDYGNYTCVASNKLGHTNASIML 310
                F+  L  F +S     + G Y C A N  G  + SI L
Sbjct: 4908 HGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 4949



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 64/281 (22%), Positives = 114/281 (40%), Gaps = 20/281 (7%)

Query: 37   TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
            TF     ++T   G++A   CT+    V    W      L + +  W        +S+ +
Sbjct: 3552 TFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAAL-SPSPNW-------RISDAE 3603

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
             ++ +E+ N+ + D G Y+C           +  LI+   P  ++    +       + L
Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHL 3663

Query: 156  TCIATGRPEPTVTWRHISPK-------AVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
             C      + TVTW     K        + F  +   LEI     + SG Y C+ASN+  
Sbjct: 3664 ECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAG 3723

Query: 209  APVVRRVKVTVNYPP-YISEAKGTGVPV-GQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
            +       VTV  PP ++ +   + + + G+   L C+    P  +  W+K++K L E  
Sbjct: 3724 SSSC-SATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESN 3782

Query: 267  KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
              V++      + L   +V   D G+Y+C A N +G  + S
Sbjct: 3783 T-VRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCS 3822



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 67/288 (23%), Positives = 111/288 (38%), Gaps = 25/288 (8%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
            F K ++ V V  G+SA+L+C +       V+W       Y G+ K  L P      + + 
Sbjct: 7963 FVKQLEPVKVSVGDSASLQCQLAGTPEIGVSW-------YKGDTK--LRPTTTYKMHFRN 8013

Query: 97   QYSIEIQN-VDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNN 152
              +  + N VD+ D G Y C  +      ++   L VQ   + P       D+    G  
Sbjct: 8014 NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLP 8073

Query: 153  ISLTCIATGRPEPTVTWRHI------SPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
            +   C  +G    +V+W         SP     F+     L I    R  +G Y C+A+N
Sbjct: 8074 VVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATN 8133

Query: 206  DV--AAPVVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
             +  A+   R +      PP+           VG+    +C  +     +  W KD + +
Sbjct: 8134 PIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREI 8193

Query: 263  IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              G K  ++      + L    V + D G YTC A N++G  + +  L
Sbjct: 8194 RSGGK-YQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQL 8240



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 63/282 (22%), Positives = 110/282 (39%), Gaps = 18/282 (6%)

Query: 47   VRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNV 105
            V+ G+S+ L C I  +   RV W      L A +DK+    R+  + +      I++ N+
Sbjct: 5435 VKAGDSSRLECKIAGSPEIRVVWFRNEHELPA-SDKY----RMTFIDSVAV---IQMNNL 5486

Query: 106  DVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEP 165
               D G + C  Q      +    +IV+  P        +   +   +SL C  +G P  
Sbjct: 5487 STEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPF 5546

Query: 166  TVTW----RHI-SPKAVGFVSEDEYLEIQGITREQS--GDYECSASNDVAAPVVRRVKVT 218
             V W    R + S K     S++ +  I  +  + S  G+Y C A N+V +         
Sbjct: 5547 EVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKL 5606

Query: 219  VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
               P ++S+     V  G+   LQ           QW K+ + +I   + +++     ++
Sbjct: 5607 KEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVA 5666

Query: 279  KLIFFNVSEHDYGNYTCVASNKLG--HTNASIMLFGPGAVSE 318
             L F      + G Y C   N  G     A++M+  P  + E
Sbjct: 5667 TLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVE 5708



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 53/220 (24%), Positives = 80/220 (36%), Gaps = 9/220 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            SI I NVD  D G Y C    D    T    + ++  P+ V+  SDIS   G  + L   
Sbjct: 7455 SIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTT 7514

Query: 159  ATGRPEPTVTW--------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
              G    +V W        R      + +      L+   +    +G Y C   ND    
Sbjct: 7515 IEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQ 7574

Query: 211  VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
                    +     + + +   V  G   TL+C  +  P    +W+KD K L    K  K
Sbjct: 7575 ECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK-YK 7633

Query: 271  VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +     +S L   NV+  D G Y+    N +G  + +  L
Sbjct: 7634 ISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL 7673



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 59/285 (20%), Positives = 111/285 (38%), Gaps = 21/285 (7%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNR--VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
            F K + +++   G+   L+ TI+    ++ V + ++  I+   ++ W        +S ++
Sbjct: 7494 FVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW--------ISYSE 7545

Query: 96   TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
               +++   V+  + G YTC ++ D   +     L V     IVE    I +  G+  +L
Sbjct: 7546 NIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTL 7605

Query: 156  TCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV- 207
             C   G PE +  W          +   + F ++   L+I  +    SG Y     N V 
Sbjct: 7606 ECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG 7665

Query: 208  --AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
              +     +V      P +  + K T    G    ++C+    P     W+ +   +  G
Sbjct: 7666 KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +K  +         L    + E D G+YTC+A+N  G    S  L
Sbjct: 7726 RK-YQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPL 7769



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 55/237 (23%), Positives = 96/237 (40%), Gaps = 27/237 (11%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS---PKIVEISSDISINEGNNISLT 156
            ++++   + D G YTC V  D         ++++     P   +  + ++++EG  + L+
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLS 8366

Query: 157  CIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
            C   G     + W    R I P    +  F S    LE++ + +  SGDY C ASN VA 
Sbjct: 8367 CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASN-VAG 8425

Query: 210  PVVRRVKVTVNYPP----------------YISEAKGTGVPVGQKGTLQCEASAVPSAEF 253
                + KVT+   P                ++SE +   V      T   +    P    
Sbjct: 8426 SDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNV 8485

Query: 254  QWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +W K   R +     V +  +   +KL   + ++ D G Y CVA N+ G   +++ L
Sbjct: 8486 KWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNL 8542



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 53/228 (23%), Positives = 89/228 (39%), Gaps = 9/228 (3%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            +E+ N+ V D G YTC         +S   L V+  P   +    I   +G ++ L C  
Sbjct: 7363 LEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECEL 7422

Query: 160  TGRPEPTVTW----RHI-SPKAVGFVSED--EYLEIQGITREQSGDYECSASNDVAAPVV 212
             G P   V+W    R + S K    +SE+    + I  +     G+Y+C A+NDV +   
Sbjct: 7423 QGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTC 7482

Query: 213  RRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
                     P ++ +       VG++  LQ            W+KD   ++     + + 
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWIS 7542

Query: 273  NRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN--ASIMLFGPGAVSE 318
                ++ L F  V   + G YTC   N  G     A++ +  P  + E
Sbjct: 7543 YSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVE 7590



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 68/290 (23%), Positives = 108/290 (37%), Gaps = 26/290 (8%)

Query: 36   ATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNT 94
            AT  +  +++ V  G++ TL CT+         W      L + N           +S  
Sbjct: 7586 ATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK--------YKISFF 7637

Query: 95   QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
                 ++I NV   D G Y+  VQ      +    L  QVS + V  S    + E N +S
Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL--QVSDRTVPPSFTRKLKETNGLS 7695

Query: 155  -----LTCIATGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGDYECS 202
                 + C   G P  +V+W H   +                 L +  +    SGDY C 
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755

Query: 203  ASNDVAAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
            A+N +A        +TV  PP ++ +     V  G   T        P     W+K    
Sbjct: 7756 ATN-MAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSE 7814

Query: 262  LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
            L+ G +   V     +++L  F+V     G YTC+ SN+ G  + +  L+
Sbjct: 7815 LVPGDR-CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLY 7863



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 72/292 (24%), Positives = 106/292 (36%), Gaps = 33/292 (11%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDP--RVVLLSNT 94
            F   ++ +    G+S +L+C +       V+W       Y G+ K    P  R    +N 
Sbjct: 6081 FVTELEPLEAAVGDSVSLQCQVAGTPEITVSW-------YKGDTKLRPTPEYRTYFTNNV 6133

Query: 95   QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGN 151
             T   +    V++ D G YTC  +      +S+    +Q   + P       DI    G 
Sbjct: 6134 AT---LVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL 6190

Query: 152  NISLTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSAS 204
             ++LTC   G     V W       R        FV     L+I       SG Y CSAS
Sbjct: 6191 PVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSAS 6250

Query: 205  NDVAAPVVRRVKVTVNYP---PYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            N +        ++T   P   P+   +     V  G+    +C  +        W KD+K
Sbjct: 6251 NPLGT-ASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNK 6309

Query: 261  RLIEGKKGVK--VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +  G       V N P L  L    V + D G YTC A+N +G    S  L
Sbjct: 6310 EIRPGGNYTITCVGNTPHLRIL---KVGKGDSGQYTCQATNDVGKDMCSAQL 6358



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 77/315 (24%), Positives = 115/315 (36%), Gaps = 31/315 (9%)

Query: 36   ATFPKAMDNVTVRQGESATLRCTIDNRVTRVA-WLNRSTILYAGNDKWCLDPRVVLLSNT 94
            AT  +   ++ V QG+ ATL+          A W      L  G+           +S T
Sbjct: 4579 ATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSK--------YKISVT 4630

Query: 95   QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGN 151
             T   ++I + +  D G YT  VQ D    + +  + V    + P   +    +   +G+
Sbjct: 4631 DTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGS 4690

Query: 152  NISLTCIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSAS 204
             I L CI  G    ++ W    + IS        F     +LEI  +    SG Y CSA+
Sbjct: 4691 FIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSAT 4750

Query: 205  NDVAAPVVRRVKVTVNYPPY-ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI 263
            N  A        +TV  PPY + + +   V    +  L+           +W+KD+K L 
Sbjct: 4751 NK-AGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELH 4809

Query: 264  EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---------GPG 314
             G     V      + L  F     D G Y C  SN +G   +   LF          P 
Sbjct: 4810 SG-AARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPS 4868

Query: 315  AVSEVSNGTSRRAGC 329
             V  + NG S    C
Sbjct: 4869 PVLVLRNGQSTTFEC 4883



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 69/280 (24%), Positives = 110/280 (39%), Gaps = 20/280 (7%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
            F K + NV      +  L C I   +  RV+W      + A +D++    R+  +  T  
Sbjct: 4115 FTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEI-AASDRY----RIAFVEGTA- 4168

Query: 97   QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLT 156
              S+EI  VD+ D G +TC        K S   LIVQ  P  V       +  G+ + L 
Sbjct: 4169 --SLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK 4226

Query: 157  CIATGRPEPTVTWRHISPKAVG----FVSE---DEYLEIQGITREQSGDYECSASNDVAA 209
                G    T+ W   + + V     ++++   +  LE+  +    SG Y C  SN VA 
Sbjct: 4227 STFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSN-VAG 4285

Query: 210  PVVRRVKVTVNYPPYISEAKGTG--VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
             V     + V  P    E       +  G    L C+ +  P  +  W+ +D+ + E  K
Sbjct: 4286 GVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK 4345

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
              ++      + L   +V   D G Y C A N+ G  + S
Sbjct: 4346 H-RMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCS 4384



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 61/267 (22%), Positives = 103/267 (38%), Gaps = 19/267 (7%)

Query: 45   VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            + +R G+S T  C I      RV+W         GN+   +    +   +    +  +I 
Sbjct: 4871 LVLRNGQSTTFECQITGTPKIRVSWY------LDGNEITAIQKHGISFIDGLATF--QIS 4922

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
               V + G Y C  + D    +  + L V+  P  +     + + + +++ L C  TG P
Sbjct: 4923 GARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTP 4982

Query: 164  EPTVTW----RHI-SPKAVGFVSEDEY--LEIQGITREQSGDYECSASNDVAAPVVRRVK 216
               VTW    R I S K            L I       +G+Y+C  SN+         +
Sbjct: 4983 PFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNE-GGSCSCSTR 5041

Query: 217  VTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
            V +  PP +I + + T   +    T Q   +  P     W KDD ++++    V +    
Sbjct: 5042 VALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDD-QILDEDDNVYISFVD 5100

Query: 276  FLSKLIFFNVSEHDYGNYTCVASNKLG 302
             ++ L   +V     G YTC A N+ G
Sbjct: 5101 SVATLQIRSVDNGHSGRYTCQAKNESG 5127



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 73/306 (23%), Positives = 117/306 (38%), Gaps = 50/306 (16%)

Query: 45   VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            VTV+ G+ A     I  R   +++W     +L  G        +   L + Q +Y++ + 
Sbjct: 3248 VTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF-------KCKFLHDGQ-EYTLLLI 3299

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS-------------PKIVEISSDISINEG 150
                 D   YTC  + D    T+   L V+V              P I+    D   +EG
Sbjct: 3300 EAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEG 3359

Query: 151  NNISLTCIATGRPEPTVTW----RHISPKAVGFVS--EDEY-LEIQGITREQSGDYECSA 203
                  C  +G  +  V+W    + I P     ++  ED Y LEI     E  G Y   A
Sbjct: 3360 QPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA 3418

Query: 204  SNDVA-----------AP-------VVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCE 244
            SN V            AP       + + +++ +   P I  + +   V +G      CE
Sbjct: 3419 SNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478

Query: 245  ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
              + P+  FQW+K  + + E  K   + +  ++S L        D G YTC ASN+ G  
Sbjct: 3479 IQSAPNVRFQWFKAGREIYESDK-CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSV 3537

Query: 305  NASIML 310
            + +  L
Sbjct: 3538 SCTATL 3543



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 68/290 (23%), Positives = 109/290 (37%), Gaps = 42/290 (14%)

Query: 43   DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            D VT  +G+ A  +C +     +V+W ++        DK     R   ++  +  Y +EI
Sbjct: 3353 DTVT-SEGQPARFQCRVSGTDLKVSWYSK--------DKKIKPSRFFRMTQFEDTYQLEI 3403

Query: 103  QNVDVYDEGPYTC------------------SVQTDNHPKTSR-VHLIVQVSPKIVEISS 143
                  DEG YT                   + ++  H +  + + + ++ +P I     
Sbjct: 3404 AEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIE 3463

Query: 144  DISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQ---S 196
             + +  G+    TC     P     W    R I       +   +Y+    I R Q    
Sbjct: 3464 PLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDC 3523

Query: 197  GDYECSASNDV-AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQ 254
            G+Y C ASN+  +      + VT  YPP ++S  K     VG+     C  +  P  E  
Sbjct: 3524 GEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETI 3583

Query: 255  WYKDDKRLIEGK--KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            W KD   L      +    EN+  L      N++  D G Y+C ASNK G
Sbjct: 3584 WQKDGAALSPSPNWRISDAENKHILE---LSNLTIQDRGVYSCKASNKFG 3630



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 62/283 (21%), Positives = 110/283 (38%), Gaps = 22/283 (7%)

Query: 37   TFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYA-GNDKWCLDPRVVLLSNT 94
            TF K +D++    G++ TL+  +  +    V W+    ++   G  K      V +L   
Sbjct: 3925 TFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLI-- 3982

Query: 95   QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
                   I +V +   G YTC  + +   +TS   LIV+   KI+E +  I +  G+  +
Sbjct: 3983 -------IPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPAT 4035

Query: 155  LTCIATGRPEPTVTWRH-----ISPK--AVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
            L     G PE    W       ++ K   + F +    L+        SG Y    SN+V
Sbjct: 4036 LEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEV 4095

Query: 208  AAPVVRRVKVTVN---YPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
             +         ++    P +    +     V     L C+ +        W+KD K +  
Sbjct: 4096 GSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAA 4155

Query: 265  GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
              +  ++      + L    V  +D GN+TC A+N +G  ++S
Sbjct: 4156 SDR-YRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSS 4197



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 44/217 (20%), Positives = 85/217 (39%), Gaps = 9/217 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+E+ N+++ D   YTC V            L V+  P  +           + +    I
Sbjct: 5293 SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAI 5352

Query: 159  ATGRPEPTVTWRH------ISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 211
              G P   + W          PK  +G      +L +  +   ++G Y C  +NDV +  
Sbjct: 5353 LKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 5412

Query: 212  VRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
               + +    P ++ + + +  V  G    L+C+ +  P     W++++  L    K  +
Sbjct: 5413 CTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDK-YR 5471

Query: 271  VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
            +     ++ +   N+S  D G++ C A N  G T+ S
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCS 5508



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 64/285 (22%), Positives = 105/285 (36%), Gaps = 29/285 (10%)

Query: 32   RSGDATFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVL 90
            R+   +F + + N     G S  L C +  +    VAW +  T + +G            
Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSG------------ 5843

Query: 91   LSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDI 145
             +  QT +S     +++ ++D  D G YTC           R  L VQ  P  V+    +
Sbjct: 5844 -AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPL 5902

Query: 146  SINEGNNISLTCIATGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGD 198
             +  G N++ T +  G P   V W   + + V        F      LE+  I   QSG+
Sbjct: 5903 EVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGE 5962

Query: 199  YECSASNDVAAPVVRRVKVTVNYP-PYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
            Y C  SN+ A       ++ V  P  ++       V  G+   L+   +        W K
Sbjct: 5963 YTCVVSNN-AGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKK 6021

Query: 258  DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            D   +   +K   +        L   N ++ D G Y+C   N+ G
Sbjct: 6022 DGFNITTSEK-CNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 54/271 (19%), Positives = 94/271 (34%), Gaps = 16/271 (5%)

Query: 48   RQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
            +QGES  L C I      +V+W    + L+   + W  +     +S   +   + I    
Sbjct: 6377 KQGESIQLECKISGSPEIKVSWFRNDSELH---ESWKYN-----MSFINSVALLTINEAS 6428

Query: 107  VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPT 166
              D G Y C         +    L V+  P   +  S +   +G+++ L C  +G P   
Sbjct: 6429 AEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFE 6488

Query: 167  VTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
            V W       R+     +     D  L I  +     G+Y C A+N+V +          
Sbjct: 6489 VVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548

Query: 220  NYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
              P ++ +   T   +G    L+            W KD   +I   +  ++     ++ 
Sbjct: 6549 EPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIAT 6608

Query: 280  LIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            L   +    + G Y C   N  G    S +L
Sbjct: 6609 LQLGSPEASNSGKYICQIKNDAGMRECSAVL 6639



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 20/249 (8%)

Query: 66   VAWLNRSTILYAGND-KWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPK 124
            + W   +TIL +G   K  +   +V         S++I      D G Y C V  +    
Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLV---------SLQILKFVAADAGEYQCRVTNEVGSS 4474

Query: 125  TSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKA-------V 177
                 + ++  P  ++     S   G   +      G    TVTW   S +        +
Sbjct: 4475 ICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRM 4534

Query: 178  GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISE-AKGTGVPVG 236
             F +    L + GI  +  G Y C A ND        + ++V  P  I+E A    V  G
Sbjct: 4535 TFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSAL-LSVKEPATITEEAVSIDVTQG 4593

Query: 237  QKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCV 296
               TLQ + S       +W+KD + L  G K  K+     +S L   +  + D G YT  
Sbjct: 4594 DPATLQVKFSGTKEITAKWFKDGQELTLGSK-YKISVTDTVSILKIISTEKKDSGEYTFE 4652

Query: 297  ASNKLGHTN 305
              N +G ++
Sbjct: 4653 VQNDVGRSS 4661



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 68/282 (24%), Positives = 113/282 (40%), Gaps = 28/282 (9%)

Query: 44   NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            +V V + +  TL C +      +V WL         + K  +  R   +S      S  I
Sbjct: 5149 SVDVTEKDPMTLECVVAGTPELKVKWLK--------DGKQIVPSRYFSMSFENNVASFRI 5200

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIV---QVSPKIVEISSDISINEGNNISLTCIA 159
            Q+V   D G YT  V+ D    +   +L V    + P   +  + +    G++I + C  
Sbjct: 5201 QSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260

Query: 160  TGRPEPTVTW----RHISPKAVGFVSEDEY---LEIQGITREQSGDYECSASNDVAAPVV 212
            +G    +  W    + IS  A   +   E    LE+  +  E + +Y C  SN VA    
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSN-VAGDDA 5319

Query: 213  RRVKVTVNYPP--YISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYKDDKRLIEGKKG 268
                +TV  PP   +   +   +P     T++ +A     P  + +W+KDD  L+ G K 
Sbjct: 5320 CSGILTVKEPPSFLVKPGRQQAIP---DSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC 5376

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              +      S L  ++V     G YTC  +N +G  + + ML
Sbjct: 5377 F-IGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417



 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 56/285 (19%), Positives = 109/285 (38%), Gaps = 20/285 (7%)

Query: 36   ATFPKAMD-NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSN 93
            ATF + ++ +  +++G++  L C +      ++ W          ND+   +     +S 
Sbjct: 4299 ATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWF--------ANDREIKESSKHRMSF 4350

Query: 94   TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
             ++   + + +V + D G Y C  Q +         +IV+ SP   +    I + +  ++
Sbjct: 4351 VESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDV 4410

Query: 154  SLTCIATGRPEPTVTW------RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASND 206
             L     G P   +TW           K   F+ +    L+I       +G+Y+C  +N+
Sbjct: 4411 MLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNE 4470

Query: 207  VAAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
            V + +    +VT+  PP +I + + T    G     Q            W KD   + E 
Sbjct: 4471 VGSSIC-SARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITE- 4528

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
               +++     ++ L    +     G Y C A N  G    S +L
Sbjct: 4529 DDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 17/226 (7%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-----SDISINEGNNI 153
            S++I   ++ D+G Y+  V+  N    S   + V VS +IV  S      D++   G ++
Sbjct: 6701 SLKIPCAEMSDKGLYSFEVK--NSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASV 6758

Query: 154  SLTCIATGRPEPTVTWRH------ISPKAVGFVSEDEY-LEIQGITREQSGDYECSASND 206
             L C  +G    +V W          PK     SE+   L +  +    +G Y C A+N 
Sbjct: 6759 VLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 6818

Query: 207  VAAPVVRRVKVTVNYPPYISEAKGT-GVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
              +     V +TV  PP   +   +  V  G   T        P  + +W+K  + L+ G
Sbjct: 6819 AGSDECSAV-LTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPG 6877

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
            +    +    F+++L  F V   + G+Y+C+ +N  G  + +  LF
Sbjct: 6878 ES-CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 54/250 (21%), Positives = 93/250 (37%), Gaps = 23/250 (9%)

Query: 81   KWCLDPRVVLLSNTQTQYSIEIQN---------VDVYDEGPYTCSVQTD---NHPKTSRV 128
            KW  D R ++ S    +Y I  +N          +++D G YT  +  +   +  +T+  
Sbjct: 4049 KWYKDGRPLVASK---KYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFT 4105

Query: 129  HLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPK---AVGFVS 181
             L   ++P   +   ++         L C   G     V+W    + I+      + FV 
Sbjct: 4106 VLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE 4165

Query: 182  EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTL 241
                LEI  +    +G++ C A+N V +       +    P ++++     V  G    L
Sbjct: 4166 GTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL 4225

Query: 242  QCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
            +           +W+K +K L+ G     +      S L  + V   D G YTC  SN  
Sbjct: 4226 KSTFQGSTPLTIRWFKGNKELVSGGS-CYITKEALESSLELYLVKTSDSGTYTCKVSNVA 4284

Query: 302  GHTNASIMLF 311
            G    S  LF
Sbjct: 4285 GGVECSANLF 4294



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 42/281 (14%)

Query: 37    TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
             T P++M   TV +GESA   C  D   V  V WL +  +L               ++ T+
Sbjct: 32565 TKPRSM---TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ--------VTTTK 32613

Query: 96    TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNN 152
              + + EI +V   DEG Y+  V+     + +   L +Q   V+ K V     +       
Sbjct: 32614 YKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVK------ 32667

Query: 153   ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
                       PEP V     SP+AV      +       + E S     S +     P  
Sbjct: 32668 ---------SPEPRVK----SPEAVKSPKRVK-------SPEPSHPKAVSPTETKPTPTE 32707

Query: 213   RRVKVTVNYPPYISE-AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
             +   + V+ PP I++  K        K T   E+S + + E  WYKD K+L E       
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH 32767

Query: 272   ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFG 312
              +     +L   N++E D G Y C  S + G +  ++   G
Sbjct: 32768 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMG 32808



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 69/289 (23%), Positives = 102/289 (35%), Gaps = 52/289 (17%)

Query: 25   VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWC 83
            VP  V +     T    + NVTV +GES TL C I    +  V W      + +      
Sbjct: 932  VPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS----- 986

Query: 84   LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
            +D ++   S       + I+     D G +TCS   +    ++  +L VQVS +      
Sbjct: 987  IDFQITFQSGIA---RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF----- 1038

Query: 144  DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV-SEDEYLEIQGITREQSGDYECS 202
                                E T      + +   FV S D  +    +T EQ+G  E +
Sbjct: 1039 ------------------EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPA 1080

Query: 203  ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
            A   +  PVV+++             +G  V  G      C+    P     W K    L
Sbjct: 1081 APYFITKPVVQKL------------VEGGSVVFG------CQVGGNPKPHVYWKKSGVPL 1122

Query: 263  IEG-KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              G +  V    +    KL+       D G YT V  NK G T+AS  L
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 55/217 (25%), Positives = 84/217 (38%), Gaps = 16/217 (7%)

Query: 116   SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW------ 169
             S+  +   KTS+    V+   +I   S+ +SINEG  + L     G  +  V W      
Sbjct: 33019 SIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD--VKWVLNGVE 33076

Query: 170   -RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNY-----PP 223
               +      G    D+ L I+  +    G   C  S      V  +  +T++      P 
Sbjct: 33077 LTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC-ISKTKEGIVKCQYDLTLSKELSDAPA 33135

Query: 224   YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFF 283
             +IS+ +   +  GQ     CE S  PS E +W+K++   I     V +     +  L   
Sbjct: 33136 FISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLP-ISISSNVSISRSRNVYSLEIR 33194

Query: 284   NVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVS 320
             N S  D G YT  A N  G  +A+  L     V E S
Sbjct: 33195 NASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPS 33231



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 54/282 (19%), Positives = 116/282 (41%), Gaps = 30/282 (10%)

Query: 47    VRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNV 105
             + +G++    C I    +  + W   +  +   ++        V +S ++  YS+EI+N 
Sbjct: 33145 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN--------VSISRSRNVYSLEIRNA 33196

Query: 106   DVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL------TCIA 159
              V D G YT  ++  N          + V P + E S ++ +    + SL        + 
Sbjct: 33197 SVSDSGKYT--IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQ 33254

Query: 160   TGRPEPTVTWRHISPKAVGFVSEDEY--LEIQGITREQSGDYECSASN--------DVAA 209
                 +   ++   S  +   ++E ++  +  Q ++  Q    E S+S+         + +
Sbjct: 33255 MSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLES 33314

Query: 210   PVVRRVKVTVNYPPYISEAKGTGVPV--GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
                + +K  +   P   EA  + + +  G+  T+ C  +  P+ E  W    +++   ++
Sbjct: 33315 STSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ 33374

Query: 268   G-VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
             G   +EN   L+ LI  +V + D G YT    N+ G  +A++
Sbjct: 33375 GRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATV 33416



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/273 (23%), Positives = 111/273 (40%), Gaps = 39/273 (14%)

Query: 40   KAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
            K + N+TV + + A     + +  V  V W+    +L + N+K+ +  +        T Y
Sbjct: 2711 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLES-NEKYAISVK-------GTIY 2762

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+ I+N  + DE  Y    +      ++R+H+    + KI++   D++  E   ++   +
Sbjct: 2763 SLRIKNCAIVDESVY--GFRLGRLGASARLHV---ETVKIIKKPKDVTALENATVAFE-V 2816

Query: 159  ATGRPEPTVTWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECSASNDVA 208
            +       V W H   K+V     D++          L +Q I+   +G+Y       V 
Sbjct: 2817 SVSHDTVPVKWFH---KSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTA-----VV 2868

Query: 209  APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEAS--AVPSAEFQWYKDDKRLIEGK 266
              +  + K+ V         K   VP  +  + +CE S   VPS    W K+    IE  
Sbjct: 2869 GQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPS---MWLKNGVE-IEMS 2924

Query: 267  KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASN 299
            +  K+  +  L +LI  N S  D   YT V  N
Sbjct: 2925 EKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)

Query: 182   EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNY-------PPYISEAKGTGVP 234
             +D+   I G+      ++   A N+      RR  +++         P    E K     
Sbjct: 30486 KDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTK 30545

Query: 235   VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
             +G+   L C+    P  + +WY+  K LI+ +K  K+ +      L      + D G YT
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRK-YKMSSDGRTHTLTVMTEEQEDEGVYT 30604

Query: 295   CVASNKLGHTNASIML 310
             C+A+N++G    S  L
Sbjct: 30605 CIATNEVGEVETSSKL 30620



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 1/102 (0%)

Query: 209  APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
            A V   V++ V  P  +S  K   V  G+  TL+C  S  PS    WY++D + IE    
Sbjct: 930  ARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ-IESSID 988

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             ++  +  +++L+       D G +TC A N+ G  + S  L
Sbjct: 989  FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYL 1030



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 64/276 (23%), Positives = 101/276 (36%), Gaps = 32/276 (11%)

Query: 31    VRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRST-ILYAGNDKWCLDPRVV 89
             V+     F K +++ TV +G +A L C +     +V W    T IL +   +   D RV 
Sbjct: 12280 VKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRV- 12338

Query: 90    LLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINE 149
                       + I +    D   YTC  +     KTS    +V    + +   +D+ + E
Sbjct: 12339 --------RKLVIHDCTPEDIKTYTCDAKDF---KTSCNLNVVPPHVEFLRPLTDLQVRE 12387

Query: 150   GNNISLTCIATGRPEPTVTW-----RHISPKAVGFVSED--EYLEIQGITREQSGDYECS 202
                    C    R    V W          K    +S+     L I     +   +Y C 
Sbjct: 12388 KEMARFEC-ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCE 12446

Query: 203   ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQ--CEASAVPSAEFQWYKDDK 260
                   + +     +TV     +       + V +  T++  CE S  P AE  WYK D+
Sbjct: 12447 VRTARTSGM-----LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDE 12500

Query: 261   RLIE-GKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
              +IE G+  +  E R  +  L+  N    D GNY C
Sbjct: 12501 EIIETGRYEILTEGRKRI--LVIQNAHLEDAGNYNC 12534



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 53/222 (23%), Positives = 88/222 (39%), Gaps = 24/222 (10%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D G YT     +    T  V+      P++++    +++  G       + +GRP+P ++
Sbjct: 3214 DAGEYTFVAGRNRSSVTLYVN--APEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3271

Query: 169  W-RHISPKAVGFVSE-----DEY-LEIQGITREQSGDYECSASND-----VAAPVVRRVK 216
            W +     + GF  +      EY L +     E +  Y C A ND      +A +   V 
Sbjct: 3272 WYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVP 3331

Query: 217  VTVN-------YPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              V+       YPP  I+  + T    GQ    QC  S     +  WY  DK+ I+  + 
Sbjct: 3332 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKK-IKPSRF 3389

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             ++       +L        D G YT VASN +G  +++  L
Sbjct: 3390 FRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3431



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 55/281 (19%), Positives = 109/281 (38%), Gaps = 37/281 (13%)

Query: 35    DATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNT 94
             +A F K + N+ V + ++  L C +      V W       Y G+++     R  +L+  
Sbjct: 12462 EAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIW-------YKGDEEIIETGRYEILTEG 12514

Query: 95    QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
             + +  + IQN  + D G Y C + +       +VH   +++ + +    ++ I EG    
Sbjct: 12515 RKRILV-IQNAHLEDAGNYNCRLPSSRTDGKVKVH---ELAAEFISKPQNLEILEGEKAE 12570

Query: 155   LTCIATGRPEPTVTWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECSAS 204
               C  +    P V W+          S D+Y          L ++  T +  G Y     
Sbjct: 12571 FVCSISKESFP-VQWKRDDKT---LESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVG 12626

Query: 205   NDVAA---PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
                AA    V+ ++++ V         K T V   Q+    CE +    A+ +W+++++ 
Sbjct: 12627 AARAAAHLTVIEKLRIVV-------PLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEA 12678

Query: 262   LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             + +  K + +  +  +  L   +    D  NY    +N  G
Sbjct: 12679 IFDSSKYI-ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRG 12718



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 40/192 (20%), Positives = 73/192 (38%), Gaps = 13/192 (6%)

Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKA-----VGFVSEDEY 185
           +P   +    + + EG+  +     +G P P V+W    + IS        + F      
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 LEIQGITREQSGDYECSASN---DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQ 242
           L I  +T+  SG Y   A+N      +     VK     P ++   +   V  G +  LQ
Sbjct: 65  LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124

Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
              + +P+   ++Y+D    I+     ++     L  L+       D G Y+  A+N +G
Sbjct: 125 VRVTGIPTPVVKFYRDGAE-IQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 303 HTNASIMLFGPG 314
              ++  L   G
Sbjct: 184 RATSTAELLVQG 195



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 71/313 (22%), Positives = 113/313 (36%), Gaps = 38/313 (12%)

Query: 38    FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGND-KWCLDPRVVLLSNTQT 96
             F + +++ TV + + A   C +      V W      +  G   K+  D  +        
Sbjct: 12825 FVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSI-------- 12876

Query: 97    QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISL 155
              + + I++  + DE  Y C V+     + SR  L V+  P +I+    DI    G ++  
Sbjct: 12877 -HRLIIKDCRLDDECEYACGVED----RKSRARLFVEEIPVEIIRPPQDILEAPGADVVF 12931

Query: 156   TCIATGRPEPTVTWRHISPKAVG-----FVSEDEY--LEIQGITREQSGDYECSASNDVA 208
                   + +  V W   +   V       +SE +   L+I  I     G+Y   A +  A
Sbjct: 12932 LA-ELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEA 12990

Query: 209   APVVRRVKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
                  R K+ +   P I  A +   V VG+  T+     A P AE +W+K+++ L     
Sbjct: 12991 -----RAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTI 13045

Query: 268   GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSNG 322
                 E   F          + D G Y  V  NK G     I L      GP    EV+  
Sbjct: 13046 DTTAEQTSFR----ILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTET 13101

Query: 323   TSRRAGCVWLLPL 335
                     W  PL
Sbjct: 13102 FDGEVSLAWEEPL 13114



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 13/144 (9%)

Query: 33    SGDAT-FPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVL 90
             SG+A    K M +VT + GE+A L C I  R +  + W            K  +  R   
Sbjct: 30529 SGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG--------KELIQSRKYK 30580

Query: 91    LSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI---VEISSDISI 147
             +S+    +++ +   +  DEG YTC    +     +   L++Q +P+      +      
Sbjct: 30581 MSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG 30640

Query: 148   NEGNNISLTCIATGRPEPTVTWRH 171
               G+ + L  +  GRP P +TW H
Sbjct: 30641 AVGSTLRLHVMYIGRPVPAMTWFH 30664



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 45/185 (24%), Positives = 72/185 (38%), Gaps = 16/185 (8%)

Query: 135   SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGF----VSED---EYLE 187
             +P I +   D++   G    L+C   GRP P + W     + +      +S D     L 
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLT 30591

Query: 188   IQGITREQSGDYECSASNDVAAPVVRRVKVTVN-----YPPYISEAKGTGVPVGQKGTLQ 242
             +    +E  G Y C A+N+V   V    K+ +      +P Y  + K  G  VG    L 
Sbjct: 30592 VMTEEQEDEGVYTCIATNEV-GEVETSSKLLLQATPQFHPGYPLKEKYYGA-VGSTLRLH 30649

Query: 243   CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDY-GNYTCVASNKL 301
                   P     W+   K L++  + + +EN    + L+  NV    + G Y    SN  
Sbjct: 30650 VMYIGRPVPAMTWFHGQK-LLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVF 30708

Query: 302   GHTNA 306
             G  +A
Sbjct: 30709 GTVDA 30713



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 59/276 (21%), Positives = 105/276 (38%), Gaps = 40/276 (14%)

Query: 40   KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS 99
            K M N+ V + ++A+  C + +      WL     +   ++K+    ++V+       + 
Sbjct: 2886 KTMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEM-SEKF----KIVVQGKL---HQ 2937

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            + I N    D   YT     D    T  V  I+     I  +  DI+  E + I+     
Sbjct: 2938 LIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIM-----ITSMLKDINAEEKDTITF---- 2988

Query: 160  TGRPEPTVTWRHISPK----AVGFVSEDEY----------LEIQGITREQSGDYECSASN 205
                E TV +  IS K     V   S D+           L I+ +    + DY   A  
Sbjct: 2989 ----EVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGK 3044

Query: 206  DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
              +   +      + +  +I + K   V   ++   +CE S  P    QW KDD+ L + 
Sbjct: 3045 ATSTATLYVEARHIEFRKHIKDIK---VLEKKRAMFECEVSE-PDITVQWMKDDQEL-QI 3099

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
               +K++   ++ +L+  +    D G YT VA   +
Sbjct: 3100 TDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNV 3135



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 36/166 (21%), Positives = 72/166 (43%), Gaps = 16/166 (9%)

Query: 138  IVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKA-------VGFVSEDEYLEIQG 190
            I +I +   + + + +    I    PE  ++W   + K        +    +   L ++ 
Sbjct: 8659 IKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKN 8718

Query: 191  ITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPS 250
               +  G+Y       V  P +   K+TV  P +    +   +  GQ  T+ C+ S VP+
Sbjct: 8719 CQLKDQGNYRL-----VCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFS-VPN 8772

Query: 251  AEFQWYKDDKRLI-EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
             + +W+++ + L  +G+   +VE++  + KL   +V   D G YTC
Sbjct: 8773 VKSEWFRNGRILKPQGRHKTEVEHK--VHKLTIADVRAEDQGQYTC 8816



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 12/134 (8%)

Query: 207   VAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
             +A  V  R+ ++V     ++   GT V       L       P     W KD   L++  
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNV------CLDATVFGKPMPTVSWKKDGT-LLKPA 19339

Query: 267   KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSN 321
             +G+K+  +  L  L  F+V+  D G+YT  A N  G  +A+I L      GP A  +++ 
Sbjct: 19340 EGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINK 19399

Query: 322   GTSRRAGCVWLLPL 335
               S RA   W  PL
Sbjct: 19400 MYSDRAMLSWEPPL 19413



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 51/227 (22%), Positives = 85/227 (37%), Gaps = 28/227 (12%)

Query: 38    FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
             F   +++ TV++GE+AT  C + +    V W      L+          R VL+S+    
Sbjct: 11576 FMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTS--------RTVLISSEGKT 11627

Query: 98    YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
             + +E++ V + D       V+  +     +V   ++  P       D +  E + I+L C
Sbjct: 11628 HKLEMKEVTLDDISQIKAQVKELSSTAQLKV---LEADPYFTVKLHDKTAVEKDEITLKC 11684

Query: 158   IATGRPEPTVTW----RHISPKAVGFVSED---EYLEIQGITREQSGDYECSASND--VA 208
               +   +  V W      I P     +  D     L+I+    +  G+Y C    D   A
Sbjct: 11685 EVS--KDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKA 11742

Query: 209   APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQW 255
                V    + V  P Y     G  V VG+    + E S  P    QW
Sbjct: 11743 NVTVEARLIKVEKPLY-----GVEVFVGETAHFEIELSE-PDVHGQW 11783



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 45/176 (25%), Positives = 74/176 (42%), Gaps = 30/176 (17%)

Query: 177   VGFVSEDEYLEIQGITREQSGDYE--------CSASNDVAAPVVRRVKVTVNYPPYISEA 228
             V  ++ED   E + I +  +G            +  +DV AP   ++KV V +   +   
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAP---KIKVDVKFKDTVI-- 21472

Query: 229   KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEH 288
                 +  G+   L+ + S  P    +W KD K L EG   ++++   F + L+  + +  
Sbjct: 21473 ----LKAGEAFRLEADVSGRPPPTMEWSKDGKEL-EGTAKLEIKIADFSTNLVNKDSTRR 21527

Query: 289   DYGNYTCVASNKLGHT----NASIM-----LFGPGAVSEVSNGTSRRAGCVWLLPL 335
             D G YT  A+N  G      N  ++       GP AV+EV   TS +    W  PL
Sbjct: 21528 DSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEV---TSEKCVLSWFPPL 21580



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 49/194 (25%), Positives = 74/194 (38%), Gaps = 33/194 (17%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIV-----QVSPKIVEISSDISINEGNNISLTCIATGRP 163
            D G +T   Q      +  V L V     QV P  VE   +++I EG+ + +   ATG P
Sbjct: 1524 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1583

Query: 164  EPTVTW--------RHISPK-AVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR- 213
             P + W         H  PK  +     +  L+I     + S  Y  +A N       R 
Sbjct: 1584 NPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRC 1643

Query: 214  RVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--------FQWYKDDKRLIEG 265
            +V V V +     E K     +  +GT + +  A P  E         QW + D  L + 
Sbjct: 1644 KVNVEVEFAEPEPERK----LIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGD--LYDK 1697

Query: 266  KKGVKVENRPFLSK 279
            +K    + +PF  K
Sbjct: 1698 EK----QQKPFFKK 1707



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 58/273 (21%), Positives = 108/273 (39%), Gaps = 36/273 (13%)

Query: 37   TFPKAMDNVTVRQGES-ATLRCTIDNRVTRVAWLNRSTILYAGNDKWCL--DPRVVLLSN 93
            TF + + +V  ++ ++ AT  C       +V W      ++ G DK+ +  D +V  LS 
Sbjct: 2175 TFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEG-DKYRMHSDRKVHFLS- 2232

Query: 94   TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
                    I  +D  D   Y+C +  D + KT+   ++     + V+   DI + E  + 
Sbjct: 2233 --------ILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSG 2284

Query: 154  SLTCIATGRPEPTV-TWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECS 202
             L CI +  PE     W H     V   S  +Y          L ++ +T+E  G+Y   
Sbjct: 2285 ELECIVS--PENIEGKWYH---NDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFV 2339

Query: 203  ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEAS-AVPSAEFQWYKDDKR 261
                     ++     +     +S+ K     V +   +Q E   ++ S E  W KD + 
Sbjct: 2340 IDGKKTTCKLKMKPRPIAILQGLSDQK-----VCEGDIVQLEVKVSLESVEGVWMKDGQE 2394

Query: 262  LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
             ++    V +        L+  ++++ D GNY+
Sbjct: 2395 -VQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS 2426



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 54/279 (19%), Positives = 110/279 (39%), Gaps = 25/279 (8%)

Query: 38   FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
            F K + ++ V +  S  L C +        W +    L + N K+ +  R       + +
Sbjct: 2269 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS-NGKYTITSR-------RGR 2320

Query: 98   YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISLT 156
             ++ +++V   D+G Y+  +      K +   L ++  P  I++  SD  + EG+ + L 
Sbjct: 2321 QNLTVKDVTKEDQGEYSFVIDG----KKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLE 2376

Query: 157  CIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
             +          W    + + P     +    +   L I+ +T+E +G+Y  +     A 
Sbjct: 2377 -VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIP---AL 2432

Query: 210  PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
             +    +V+V     I+  K   V  G K  L+C+ S       +WY +D++ I+    V
Sbjct: 2433 GLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ-IKPDDRV 2491

Query: 270  KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
            +   +    +L+       D G Y  +      + N S+
Sbjct: 2492 QAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSV 2530



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 38/175 (21%), Positives = 69/175 (39%), Gaps = 32/175 (18%)

Query: 50    GESATLRCTIDNRVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVY 108
             G SA   C +        W+ + S I  +   ++  D +            + I +V + 
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGK---------DRKLHIIDVQLS 11183

Query: 109   DEGPYTCSVQTDNHPKTSRVHLIVQVSPK--IVEISSDISINEGNNISLTCIATGRPEPT 166
             D G YTC ++  N  KTS   L+V+  P   +  +  ++++ +G  + L+C      E  
Sbjct: 11184 DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL--NKERD 11241

Query: 167   VTWR-----------HISPKAVGFV-------SEDEYLEIQGITREQSGDYECSA 203
             V WR            I P  +G +       ++D       +T E + + ECS+
Sbjct: 11242 VVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSS 11296



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 50/226 (22%), Positives = 84/226 (37%), Gaps = 33/226 (14%)

Query: 131   IVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG 190
             I  +S   V +S      +G +     I   R  P   W   S      V+E +++ I G
Sbjct: 26776 ITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKAS---FTNVTETQFI-ISG 26831

Query: 191   ITREQSGDYECSASN---------DVAAPVV-------RRVKVTVNYPPYISEAKGTGVP 234
             +T+    ++   A N         +V  P+          + + + Y   +    GT V 
Sbjct: 26832 LTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVK 26891

Query: 235   VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
                   L+   S  P+   +WYKDDK L +    V VEN   L+ ++  +    + G Y 
Sbjct: 26892 ------LRAGISGKPAPTIEWYKDDKEL-QTNALVCVENTTDLASILIKDADRLNSGCYE 26944

Query: 295   CVASNKLGHTNASIML------FGPGAVSEVSNGTSRRAGCVWLLP 334
                 N +G  +A+I +        PG   E    T+ +   +W  P
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPP 26990



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 40/174 (22%), Positives = 69/174 (39%), Gaps = 15/174 (8%)

Query: 135  SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR------HISPKAVGFVSEDEYLE- 187
            +PKI E     ++ +G++        G+P+P   W         S +   +  ED   E 
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCEL 2136

Query: 188  -IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQK----GTLQ 242
             I+ +T E S      A N +A        + V     I+  +     V ++     T +
Sbjct: 2137 VIRDVTAEDSASIMVKAIN-IAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2195

Query: 243  CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCV 296
            CE S  P  + +WYKD   + EG K  ++ +   +  L    +   D  +Y+CV
Sbjct: 2196 CETSE-PFVKVKWYKDGMEVHEGDK-YRMHSDRKVHFLSILTIDTSDAEDYSCV 2247



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 40/204 (19%), Positives = 73/204 (35%), Gaps = 15/204 (7%)

Query: 121   NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG-- 178
             + P T +  + +Q +P   E   ++++   +N +L C  TG P+P V W     + +   
Sbjct: 30914 SEPITPKSDVPIQ-APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 30972

Query: 179   -------FVSEDEYLEIQGITREQSGDYECSASN-----DVAAPVVRRVKVTVNYPPYIS 226
                    F      L I  +T + +  Y+  A+N        A +   V   ++ P  + 
Sbjct: 30973 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 31032

Query: 227   EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVS 286
                      G+  +++   S  P     W K    +        +  R F S +    V 
Sbjct: 31033 GMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVE 31092

Query: 287   EHDYGNYTCVASNKLGHTNASIML 310
               D G Y   A N+ G    ++ L
Sbjct: 31093 RKDAGFYVVCAKNRFGIDQKTVEL 31116



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 52/256 (20%), Positives = 83/256 (32%), Gaps = 47/256 (18%)

Query: 102   IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ------------VSPKIVEISSDISINE 149
             ++++   D+G Y C V  D    +S   L V+               KI   +  + + E
Sbjct: 31628 VKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE 31687

Query: 150   ----------------GNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------- 185
                             G N+      T  PEP VTW     K     ++ +Y        
Sbjct: 31688 RPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGL 31747

Query: 186   --LEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNYPPYISEAK--------GTGVP 234
               L I  +T +   +Y   A N       + ++ VT++ PP  S  +             
Sbjct: 31748 YQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQ 31807

Query: 235   VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
              GQ    +   S +P    +W KD + L  G     +        L   +    D G Y 
Sbjct: 31808 EGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYR 31867

Query: 295   CVASNKLGHTNASIML 310
               A+N  G T+    L
Sbjct: 31868 VTATNTAGSTSCQAHL 31883



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 22/88 (25%), Positives = 44/88 (50%), Gaps = 7/88 (7%)

Query: 133   QVSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQ 189
             Q +P+I   V++ + +++  G  I L    TG+PEP +TW     KA   + +D+ + I+
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITW----TKADMILKQDKRITIE 13740

Query: 190   GITREQSGDYECSASNDVAAPVVRRVKV 217
              + ++ +     S  +D    ++  V V
Sbjct: 13741 NVPKKSTVTIVDSKRSDTGTYIIEAVNV 13768



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 39/166 (23%), Positives = 70/166 (42%), Gaps = 10/166 (6%)

Query: 177   VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT-GVPV 235
             V  ++ED+  E + I +  +G    S  +D   P+  + +V +       + + T  V  
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNA 23639

Query: 236   GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
             G+   L+ +    P    +W + DK + E  +  +++N  F + LI  +    D G Y  
Sbjct: 23640 GETFRLEADVHGKPLPTIEWLRGDKEIEESAR-CEIKNTDFKALLIVKDAIRIDGGQYIL 23698

Query: 296   VASNKLGHTNASI---MLFGPGAVS---EVSNGTSRRAGCVWLLPL 335
              ASN  G  +  +   +L  PG      +V+  TS +    W  PL
Sbjct: 23699 RASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPL 23744



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 1/107 (0%)

Query: 205   NDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI- 263
             ++++ P+  +  V +  P +  E +   V      TL C+ +  P    +WY+  K +I 
Sbjct: 30911 SEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA 30970

Query: 264   EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +G K    E +    +LI  +V++ D   Y   A+N+ G  + +  L
Sbjct: 30971 DGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASL 31017



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 17/182 (9%)

Query: 37  TFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
           TF + + +V V +G +AT    I    V  V+W     ++             V +S + 
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPG------VQISFSD 60

Query: 96  TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS---PKIVEISSDISINEGNN 152
            +  + I  V   + G Y+      +   TS   L+V+     P  V+    +++ +G+ 
Sbjct: 61  GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120

Query: 153 ISLTCIATGRPEPTVTWRHISPK---AVGFVSEDE----YLEIQGITREQSGDYECSASN 205
           + L    TG P P V +     +   ++ F    E     L I     E SG Y  +A+N
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180

Query: 206 DV 207
            V
Sbjct: 181 SV 182



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 116   SVQTDNHPKTSRVHLIVQVSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTWRH- 171
             ++   + P      L   V P+I   V + S +++  G N+ L     G+P PTV+W+  
Sbjct: 19273 NISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 19332

Query: 172   --ISPKAVGFVSEDE----YLEIQGITREQSGDYECSASN 205
               +   A G     +     LE+  + R+ SGDY  +A N
Sbjct: 19333 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAEN 19372



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 57/242 (23%), Positives = 95/242 (39%), Gaps = 37/242 (15%)

Query: 40    KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS 99
             + + +VTV  GE+AT  C +      V W       Y    K     +VV  S  +  ++
Sbjct: 12200 RPLKDVTVTAGETATFDCELSYEDIPVEW-------YLKGKKLEPSDKVVPRSEGKV-HT 12251

Query: 100   IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISLTCI 158
             + +++V + D G     VQ       +  +L V+  P +  +   D ++ EG    L C 
Sbjct: 12252 LTLRDVKLEDAG----EVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLEC- 12306

Query: 159   ATGRPEPTVTW-----RHISPKAVGFVSEDEY--LEIQGITREQSGDYECSASNDVAAPV 211
                R    V W       +  K    V++     L I   T E    Y C A +      
Sbjct: 12307 EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD------ 12360

Query: 212   VRRVKVTVN---YPPYISEAKG-TGVPVGQK--GTLQCEASAVPSAEFQWYKDDKRLIEG 265
                 K + N    PP++   +  T + V +K     +CE S   +A+ +W+KD   + +G
Sbjct: 12361 ---FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGAEIKKG 12416

Query: 266   KK 267
             KK
Sbjct: 12417 KK 12418



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 133   QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEY 185
             Q+ P  + +   I+I  G  + +     G+P PT  W+         S  AV        
Sbjct: 18896 QLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 18955

Query: 186   LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
             L I+ +TR+ SG Y  +A N  +    +++KV V   P
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENS-SGTDTQKIKVVVMDAP 18992



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 45/216 (20%), Positives = 72/216 (33%), Gaps = 52/216 (24%)

Query: 51    ESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDE 110
             E A L C +++ V R     +    Y    K   +       +    Y ++I N+   D+
Sbjct: 32731 EIAKLTCVVESSVLRA----KEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQ 32786

Query: 111   GPYTCSVQTDN-----------------HPKTSRVHLI---------------------- 131
             G Y C +  +                  H K S++                         
Sbjct: 32787 GEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPE 32846

Query: 132   -VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDE-- 184
              +   P IV    D +++  +       ATG P PT  W    + I+      +SED+  
Sbjct: 32847 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 32906

Query: 185   -YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
              +LEI       SG Y C+  N  A  V    K+T+
Sbjct: 32907 FFLEIHKTDTSDSGLYTCTVKNS-AGSVSSSCKLTI 32941



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 26/86 (30%), Positives = 36/86 (41%)

Query: 226  SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNV 285
            S  K   +  G   T  C+ S  P  +  WYKD KR+  G++      +   + L    V
Sbjct: 1295 SRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVV 1354

Query: 286  SEHDYGNYTCVASNKLGHTNASIMLF 311
               D G YT  ASN  G+   S  L+
Sbjct: 1355 LPEDEGIYTAFASNIKGNAICSGKLY 1380



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 27/95 (28%), Positives = 38/95 (40%), Gaps = 6/95 (6%)

Query: 145   ISINEGNNISLTCIATGRPEPTVTWRHIS------PKAVGFVSEDEYLEIQGITREQSGD 198
             + +  G  I L  I  GRP P VTWR +          V  V    +L I   TR+ SG 
Sbjct: 18616 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGK 18675

Query: 199   YECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGV 233
             Y  +  N      V      ++ P  +S+ K + V
Sbjct: 18676 YSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDV 18710



 Score = 36.2 bits (82), Expect = 0.044
 Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 6/110 (5%)

Query: 230   GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHD 289
             G  V  G K  L    +  P  +  W K D  L + K+ + +EN P  S +   +    D
Sbjct: 13699 GLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR-ITIENVPKKSTVTIVDSKRSD 13757

Query: 290   YGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSNGTSRRAGCVWLLP 334
              G Y   A N  G   A + +      GP A  ++++ T+      W  P
Sbjct: 13758 TGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPP 13807



 Score = 36.2 bits (82), Expect = 0.044
 Identities = 28/108 (25%), Positives = 43/108 (39%), Gaps = 6/108 (5%)

Query: 233   VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGN 292
             V VGQ   +       P  +  W K+ K L+  K+   +++ P + +L        D+G 
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV-ELQIKEAVRADHGK 17978

Query: 293   YTCVASNKLGHTNASIMLF-----GPGAVSEVSNGTSRRAGCVWLLPL 335
             Y   A N  GH   S ++      GP    +V+N T       W  PL
Sbjct: 17979 YIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPL 18026



 Score = 36.2 bits (82), Expect = 0.044
 Identities = 23/88 (26%), Positives = 34/88 (38%), Gaps = 7/88 (7%)

Query: 139   VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-------AVGFVSEDEYLEIQGI 191
             V + + +    G ++ +     GRP PTVTWR            ++        L I  +
Sbjct: 27275 VALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQV 27334

Query: 192   TREQSGDYECSASNDVAAPVVRRVKVTV 219
             TR  +G Y  +  N V  P    V V V
Sbjct: 27335 TRNDTGKYILTIENGVGEPKSSTVSVKV 27362



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 4/97 (4%)

Query: 236   GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
             G+K ++     AVP     W+KD K  ++    + ++N    + L        D G YT 
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKE-VKASDRLTMKNDHISAHLEVPKSVRADAGIYTI 14459

Query: 296   VASNKLGHTNASI---MLFGPGAVSEVSNGTSRRAGC 329
                NKLG   ASI   ++  PG   ++      ++ C
Sbjct: 14460 TLENKLGSATASINVKVIGLPGPCKDIKASDITKSSC 14496



 Score = 33.5 bits (75), Expect = 0.28
 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 9/87 (10%)

Query: 141   ISSDISINEGNNISLTCIAT-GRPEPTVTW----RHISPKAVGFVSE---DEYLEIQGIT 192
             I   ++I  G+ I L  I+  G+P P  +W    + I P  +  ++       L I+  T
Sbjct: 20384 IKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYAT 20443

Query: 193   REQSGDYECSASNDVAAPVVRRVKVTV 219
             R+ +G+Y  +A+N      V  VKVTV
Sbjct: 20444 RKDAGEYTITATNPFGTK-VEHVKVTV 20469



 Score = 33.5 bits (75), Expect = 0.28
 Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 6/92 (6%)

Query: 249   PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG----HT 304
             P  +  W K  K  I      ++ + P  S L     +  D G YT  A+N  G    H 
Sbjct: 20407 PLPKSSWSKAGKD-IRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHV 20465

Query: 305   NASIM-LFGPGAVSEVSNGTSRRAGCVWLLPL 335
               +++ + GP    E+SN ++ +A   W  PL
Sbjct: 20466 KVTVLDVPGPPGPVEISNVSAEKATLTWTPPL 20497



 Score = 33.5 bits (75), Expect = 0.28
 Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 2/96 (2%)

Query: 211   VVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
             V+ +   T+++ P I+   +   VP GQ         + P+AE +WY +   L E  K +
Sbjct: 32362 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSK-I 32420

Query: 270   KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
                N   +  L   +    D G Y  V +N  G  +
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEAS 32456



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 21/88 (23%), Positives = 38/88 (43%), Gaps = 11/88 (12%)

Query: 95    QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS-------PKIVEISSDISI 147
             + Q+++E    D+ + G Y   V+  N    S+    V          P  +++   + +
Sbjct: 16073 ELQFTVE----DLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV 16128

Query: 148   NEGNNISLTCIATGRPEPTVTWRHISPK 175
              EG N+++     G P PT+TW    PK
Sbjct: 16129 EEGTNVNIVAKIKGVPFPTLTWFKAPPK 16156



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 7/65 (10%)

Query: 150   GNNISLTCIATGRPEPTVTWRH-----ISPKAVGF--VSEDEYLEIQGITREQSGDYECS 202
             G+NI +     GRP+PTVTW+         + V F   +    L I    R  SG Y  +
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 21139

Query: 203   ASNDV 207
             A N V
Sbjct: 21140 ARNIV 21144



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 22/110 (20%), Positives = 50/110 (45%), Gaps = 10/110 (9%)

Query: 123   PKTSRVHLIVQ---VSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRH--ISPKAV 177
             P++  V ++ +   + P +    S  S+  G ++ +    +GRP+PT+TW    +  K  
Sbjct: 23214 PRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQT 23273

Query: 178   GFVSEDEYLEIQGIT-----REQSGDYECSASNDVAAPVVRRVKVTVNYP 222
               ++  + L++  ++     ++  G Y  + +N V         VT++ P
Sbjct: 23274 TRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323



 Score = 32.7 bits (73), Expect = 0.49
 Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 22/121 (18%)

Query: 112   PYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR- 170
             P    +Q D  P T ++ L V+           I +  G  + +    TG P P + W  
Sbjct: 15383 PLNVVIQDDEVPPTIKLRLSVR--------GDTIKVKAGEPVHIPADVTGLPMPKIEWSK 15434

Query: 171   ------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
                          I+ + V        L I    RE  G Y  +ASN + + V R V V 
Sbjct: 15435 NETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS-VFRNVHVE 15493

Query: 219   V 219
             V
Sbjct: 15494 V 15494



 Score = 32.3 bits (72), Expect = 0.63
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 21/109 (19%)

Query: 115   CSVQTDN--HPKTSRVHLIVQ--VSPKIVEISSDIS----INEGNNISLTCIATGRPEPT 166
             C++ ++    P T    ++ Q  + P  +E+ +D+     +     + L     GRPEP 
Sbjct: 25079 CAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 25138

Query: 167   VTWRHISPKAVGFVSEDEYLE---------IQGITREQSGDYECSASND 206
             V W     KA G +++   +E         I  +TR  SG Y  +  N+
Sbjct: 25139 VKWE----KAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN 25183



 Score = 32.3 bits (72), Expect = 0.63
 Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 17/118 (14%)

Query: 97    QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNN 152
             +YS  +  V+V     Y+ S+        + +  + ++    +E++ D    ++I  G +
Sbjct: 29412 KYSFRVAAVNVKGMSEYSESI--------AEIEPVERIEIPDLELADDLKKTVTIRAGAS 29463

Query: 153   ISLTCIATGRPEPTVTWR----HISPKAVGFVSED-EYLEIQGITREQSGDYECSASN 205
             + L    +GRP P +TW      ++ +A+   +E    L +  + R  +G Y   A N
Sbjct: 29464 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 29521



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 33/178 (18%), Positives = 70/178 (39%), Gaps = 23/178 (12%)

Query: 35   DATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYA-GNDKWCLDPRVVLLSN 93
            +  + + + +VT+++G++ T+ C       +  W     IL   G  K  ++ +V     
Sbjct: 8744 EPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEVEHKV----- 8798

Query: 94   TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNN 152
                + + I +V   D+G YTC  +       +   L ++  P +  +   +I ++E  +
Sbjct: 8799 ----HKLTIADVRAEDQGQYTCKYE----DLETSAELRIEAEPIQFTKRIQNIVVSEHQS 8850

Query: 153  ISLTCIATGRPEPTVTW-----RHISPKAVGFVSED--EYLEIQGITREQSGDYECSA 203
             +  C      +  VTW          +   F ++    Y+ I  +T +  G Y   A
Sbjct: 8851 ATFEC-EVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIA 8907



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 28/118 (23%), Positives = 43/118 (36%), Gaps = 19/118 (16%)

Query: 98    YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE----ISSDISINEGNNI 153
             Y + +  V+   EGP           +T  V +     P  VE    +   I I  G  +
Sbjct: 15072 YKLRVSAVNAAGEGP---------PGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 15122

Query: 154   SLTCIATGRPEPTVTWRHISPK------AVGFVSEDEYLEIQGITREQSGDYECSASN 205
              +  + TGRP PT  W     +       +  V     L I+   R+  G Y  +A+N
Sbjct: 15123 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATN 15180



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 7/68 (10%)

Query: 145   ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQ--GITREQSG 197
             I++  G  I +     GRPEP +TW       +  K V  + +   +E+Q     R   G
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 17977

Query: 198   DYECSASN 205
              Y  SA N
Sbjct: 17978 KYIISAKN 17985



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 36/161 (22%), Positives = 65/161 (40%), Gaps = 9/161 (5%)

Query: 182   EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT-GVPVGQKGT 240
             ED+  E + I R  +G++  S  +D +  +  R ++         + K    V  G+   
Sbjct: 24669 EDQRYEFRVIARNAAGNF--SEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFV 24726

Query: 241   LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
             L+ +    P  +  W KD K L E    +++++    + L+  +    D G Y    SN 
Sbjct: 24727 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 24786

Query: 301   LGHTNASI---MLFGPGAVS---EVSNGTSRRAGCVWLLPL 335
              G  +  I   +L  PG      +V+  T+ +    W  PL
Sbjct: 24787 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPL 24827



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 25/106 (23%), Positives = 45/106 (42%), Gaps = 15/106 (14%)

Query: 45    VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
             VT+R G S  L  ++  R   V   ++  I  A            ++  T++   + +  
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR---------AIIDTTESYSLLIVDK 29506

Query: 105   VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP------KIVEISSD 144
             V+ YD G YT   +  +  K++ V + V  +P      K+ E+S D
Sbjct: 29507 VNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRD 29552



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 39/201 (19%), Positives = 73/201 (36%), Gaps = 36/201 (17%)

Query: 14    LVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRST 73
             L++  +RL FL P               + +VT ++ ESA     + +   RV W     
Sbjct: 11922 LIIEGIRLKFLTP---------------LKDVTAKEKESAVFTVELSHDNIRVKWFK--- 11963

Query: 74    ILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHL-IV 132
                  ND+     R V + +    +SI  +++ + D    T  ++ +    +S   L ++
Sbjct: 11964 -----NDQRLHTTRSVSMQDEGKTHSITFKDLSIDD----TSQIRVEAMGMSSEAKLTVL 12014

Query: 133   QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSED---EY 185
             +  P       D +  E + + L C    + +  V W    + I P     +  D     
Sbjct: 12015 EGDPYFTGKLQDYTGVEKDEVILQC-EISKADAPVKWFKDGKEIKPSKNAVIKADGKKRM 12073

Query: 186   LEIQGITREQSGDYECSASND 206
             L ++   +   G Y C    D
Sbjct: 12074 LILKKALKSDIGQYTCDCGTD 12094



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 135   SPKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
             +PK++ + + + +  G+ I+L    +G P PT+TW
Sbjct: 14680 APKVI-LRTSLEVKRGDEIALDASISGSPYPTITW 14713



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 6/78 (7%)

Query: 147   INEGNNISLTCIATGRPEPTVTWRHISPKA-----VGFVSEDEYLEIQGITREQSGDYEC 201
             I  G+ + L+ I  G P P VTW+     A     +        LEI+    E  G Y  
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSL 17289

Query: 202   SASNDVAAPVVRRVKVTV 219
             +  N   +  V  VKV V
Sbjct: 17290 TVENPAGSKTV-SVKVLV 17306



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 12/125 (9%)

Query: 182   EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKG-T 240
             E++  E +  T+ + G+ +   + +V       VK  +  P  + + K +GV   + G T
Sbjct: 18167 ENQIYEFRVQTKNEGGESDWVKTEEVV------VKEDLQKP--VLDLKLSGVLTVKAGDT 18218

Query: 241   LQCEASA--VPSAEFQWYKD-DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVA 297
             ++ EA     P  E  W KD D   +     VK++ R   SK         D G Y   A
Sbjct: 18219 IRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTA 18278

Query: 298   SNKLG 302
             +N  G
Sbjct: 18279 TNTAG 18283



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 30/124 (24%), Positives = 51/124 (41%), Gaps = 17/124 (13%)

Query: 136   PKIVEISSD----ISINEGNNISLTCIATGRPEPTVTW--------RHISPKAVGFVSED 183
             P IVE   +    + I  G ++ +  +  GRP P VTW        + ++ +    +   
Sbjct: 27955 PPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST 28014

Query: 184   EYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP--YISEAKGTGVPVGQKGTL 241
               L ++  TR+  G Y   A N  +      +KV V   P   +   + T +  G+K TL
Sbjct: 28015 S-LFVRDATRDHRGVYTVEAKN-ASGSAKAEIKVKVQDTPGKVVGPIRFTNI-TGEKMTL 28071

Query: 242   QCEA 245
               +A
Sbjct: 28072 WWDA 28075



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 17/70 (24%), Positives = 27/70 (38%), Gaps = 1/70 (1%)

Query: 233   VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGN 292
             + VG+   L    S  P  +  W+KD+  ++E  +   ++  P    L        D G 
Sbjct: 16830 IRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDR-THIKTTPATLALEKIKAKRSDSGK 16888

Query: 293   YTCVASNKLG 302
             Y  V  N  G
Sbjct: 16889 YCVVVENSTG 16898



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 22/93 (23%), Positives = 37/93 (39%), Gaps = 8/93 (8%)

Query: 249   PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
             P+ E +W K D  +   +    ++     + L+  NV+ +D G YT    N  G  +A +
Sbjct: 22970 PTPEVKWGKVDGEI---RDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFV 23026

Query: 309   MLF-----GPGAVSEVSNGTSRRAGCVWLLPLL 336
              +       P    +V+  T       W  PLL
Sbjct: 23027 TVRVLDTPSPPVNLKVTEITKDSVSITWEPPLL 23059



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 6/61 (9%)

Query: 90    LLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP------KIVEISS 143
             ++  T +  S+ + NV+ YD G YT +++  +  K++ V + V  +P      K+ EI+ 
Sbjct: 22988 IIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITK 23047

Query: 144   D 144
             D
Sbjct: 23048 D 23048



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 41/187 (21%), Positives = 69/187 (36%), Gaps = 25/187 (13%)

Query: 38    FPKAMDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAG-NDKWCLDPRVVLLSNTQ 95
             F   + N T   GE+     TI  +    V W      +  G NDK           + +
Sbjct: 31692 FTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK------KYTFESDK 31745

Query: 96    TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE---------ISSDIS 146
               Y + I +V   D+  YT   +      + +  L V + P   +         + ++  
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805

Query: 147   INEGNNISLTCIATGRPEPTVTW-RHISPKAVGFVSE------DEY-LEIQGITREQSGD 198
               EG ++      +G P PT+ W +   P ++G   E      D Y L I+    E +G 
Sbjct: 31806 CQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGY 31865

Query: 199   YECSASN 205
             Y  +A+N
Sbjct: 31866 YRVTATN 31872



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 14/112 (12%)

Query: 24    LVPTGVPVRSGDATFPKAMDN-VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKW 82
             LV   +PVR     F K ++  VTV +G+   L C + N+   V W     I+     + 
Sbjct: 11205 LVVEELPVR-----FVKTLEEEVTVVKGQPLYLSCEL-NKERDVVWRKDGKIVVEKPGR- 11257

Query: 83    CLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 134
              + P V+ L    T     I + D  D G YT +V+  N+ + S    +V+V
Sbjct: 11258 -IVPGVIGLMRALT-----INDADDTDAGTYTVTVENANNLECSSCVKVVEV 11303



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 5/109 (4%)

Query: 225   ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFN 284
             +S   G  +  G+   +    +  P     W K++  L   K  V ++N    S+LI  +
Sbjct: 15108 VSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGEL--DKDRVVIDNVGTKSELIIKD 15165

Query: 285   VSEHDYGNYTCVASNKLG--HTNASIMLFG-PGAVSEVSNGTSRRAGCV 330
                 D+G Y   A+N  G     A + +F  PG V ++    + R  C+
Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 15214



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 23/93 (24%), Positives = 36/93 (38%), Gaps = 8/93 (8%)

Query: 249   PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
             P+ E +W +D    ++      +E+    + LI  NV+  D G Y     N  G  +A +
Sbjct: 21888 PAPEVKWARDHGESLDK---ASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944

Query: 309   MLF-----GPGAVSEVSNGTSRRAGCVWLLPLL 336
              +      GP    +V   T       W  PLL
Sbjct: 21945 NVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLL 21977



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 18/72 (25%), Positives = 29/72 (40%), Gaps = 5/72 (6%)

Query: 139   VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-----AVGFVSEDEYLEIQGITR 193
             +E+   I+I  G ++ L     GRP P V W  +  +      +   S    L +  + R
Sbjct: 22946 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNR 23005

Query: 194   EQSGDYECSASN 205
               SG Y  +  N
Sbjct: 23006 YDSGKYTLTLEN 23017



 Score = 28.9 bits (63), Expect = 7.0
 Identities = 12/34 (35%), Positives = 15/34 (44%)

Query: 136  PKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
            P IV     + + EG      C  TG P+P V W
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNW 1874



 Score = 28.9 bits (63), Expect = 7.0
 Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 8/81 (9%)

Query: 134   VSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEY 185
             VSP +     +   I ++ G  I +    +G+P PTVTW    R +  +A +   +    
Sbjct: 16520 VSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS 16579

Query: 186   LEIQGITREQSGDYECSASND 206
             + I+   R   G Y   A N+
Sbjct: 16580 MVIKNCQRSHQGVYSLLAKNE 16600



 Score = 28.9 bits (63), Expect = 7.0
 Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 13/97 (13%)

Query: 249   PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
             P     W KD+K L    +   +EN    S L    V+ +D G Y     N +G   +S 
Sbjct: 27299 PPPTVTWRKDEKNLGSDAR-YSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357

Query: 309   ----MLFGPGA-----VSEVSNGTSRRAGCVWLLPLL 336
                 +L  P A     V  VS GT      +W  PL+
Sbjct: 27358 VSVKVLDTPAACQKLQVKHVSRGT---VTLLWDPPLI 27391



 Score = 28.9 bits (63), Expect = 7.0
 Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 10/95 (10%)

Query: 143   SDISINEGNNISLTCIATGRPEPTVTWRH--ISPKAVGFV--SEDE---YLEIQGITREQ 195
             + +++  G+N+ L     G+P+P+++W    +  K   FV  S+ E    L I+   +E 
Sbjct: 27571 AQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEH 27630

Query: 196   SGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKG 230
              G Y     N V    V    +T+  P   S+ KG
Sbjct: 27631 GGKYTVILDNAVCRIAVPITVITLGPP---SKPKG 27662


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 83/290 (28%), Positives = 111/290 (38%), Gaps = 24/290 (8%)

Query: 28  GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDP 86
           G P R    TF     N  V  GES TL C+       R++W               +DP
Sbjct: 337 GSPARP---TFVIQPQNTEVLVGESVTLECSATGHPPPRISWTR------GDRTPLPVDP 387

Query: 87  RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS 146
           RV    N      + IQNV   D G Y CS   +     +   +IVQ  P+      D  
Sbjct: 388 RV----NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRV 443

Query: 147 INEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECS 202
           + EG  +   C A G P P + W      +S      V     L I G+     G YEC 
Sbjct: 444 VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQ 503

Query: 203 ASNDVAA-PVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
           A N + +  VV  + V     P + S    T V VG    L C +   P     W KD  
Sbjct: 504 AVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563

Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           ++ E  K   +    FL+     +V   D G Y CVA N +G  + S++L
Sbjct: 564 QVTESGK-FHISPEGFLT---INDVGPADAGRYECVARNTIGSASVSMVL 609



 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 17/187 (9%)

Query: 136 PKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVS--EDEYLEIQ 189
           P+I     D  +  GN +  TC A G P+P + W      +S K    ++  +D  L IQ
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305

Query: 190 GITREQSGDYECSASNDVAAPVVRRVKVTVNY------PPYISEAKGTGVPVGQKGTLQC 243
                  G Y+C A N   A  V+  +VT+ Y      P ++ + + T V VG+  TL+C
Sbjct: 306 NTQETDQGIYQCMAKN--VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363

Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGH 303
            A+  P     W + D+  +     V +        L   NV + D G Y C A+N +  
Sbjct: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPS---GGLYIQNVVQGDSGEYACSATNNIDS 420

Query: 304 TNASIML 310
            +A+  +
Sbjct: 421 VHATAFI 427


>gi|24111244 MAM domain containing glycosylphosphatidylinositol
           anchor 1 [Homo sapiens]
          Length = 955

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 76/274 (27%), Positives = 124/274 (45%), Gaps = 28/274 (10%)

Query: 49  QGESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
           Q ++  LRCT++ N   R  W   S  L    D   +D    L +  +T+  ++++N+  
Sbjct: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNG-VDIYEPLYTQGETKV-LKLKNLRP 206

Query: 108 YDEGPYTCSVQTDN----HPKTSRVHLIVQVSPKIVEISSD--ISINEGNNISLTCIATG 161
            D   YTC V   N      K     L    +P  +++S +  + +N G N+++ C+ TG
Sbjct: 207 QDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTG 266

Query: 162 R-PEPTVTWRH-ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
             P P + W H   P  +G +++   L I  +    SG Y C+A+N+V  P  + V + V
Sbjct: 267 GDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV 326

Query: 220 N---------YPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQWYKDDKRLIEGKKG 268
                      P  I E++   + +GQ   L C   AVP  +  +QW+K+ K     K+ 
Sbjct: 327 RSMKNATFQITPDVIKESE--NIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRL 384

Query: 269 VKVENRPFL----SKLIFFNVSEHDYGNYTCVAS 298
           +   N P L    S L   ++   DYG Y C+AS
Sbjct: 385 LVTRNDPELPAVTSSLELIDLHFSDYGTYLCMAS 418



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 50/172 (29%), Positives = 74/172 (43%), Gaps = 22/172 (12%)

Query: 146 SINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSE----DEYLEIQGITREQSGDYEC 201
           +I EG+ + L C+ TG P P V W   +  A     E    +E L I+ I R Q G Y C
Sbjct: 49  TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108

Query: 202 SASNDVAAPVVRRVKVTVNY--------PPYISEAKGTGVPVGQKGT--LQCEASAVPSA 251
            A N V  P ++ ++V V Y           +S+ +G      Q+ T  L+C  ++ P A
Sbjct: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGN---FYQEKTVFLRCTVNSNPPA 165

Query: 252 EFQWYKDDKRLIEGK-KGVKVENRPF----LSKLIFFNVSEHDYGNYTCVAS 298
            F W +    L   +  GV +    +       L   N+   DY +YTC  S
Sbjct: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS 217



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 77/319 (24%), Positives = 127/319 (39%), Gaps = 60/319 (18%)

Query: 17  VSLRLLFLVPT-GVPVRSGDATFPKAM-----DNVTVRQGESATLRCTIDNRVTRVAWLN 70
           VS+R +  +P   +  R  + T P A+     + + V  GE+ T++C             
Sbjct: 216 VSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQC------------- 262

Query: 71  RSTILYAGND-----KWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD-NHPK 124
               L  G D     +W   P  + L       ++ I +V   D G Y C+   +  +P 
Sbjct: 263 ----LLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPA 318

Query: 125 TSRVHLIV--------QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR------ 170
              V+L+V        Q++P +++ S +I +  G ++ L+C     P+  VT++      
Sbjct: 319 KKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGK 376

Query: 171 --HISPKAVGFVSEDEY------LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-- 220
              +S + +   ++ E       LE+  +     G Y C AS   A      V+V ++  
Sbjct: 377 PARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSE 436

Query: 221 -YPPYISEAKGTGVPVGQKGT---LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
             PP IS  KG  V   ++G+   LQCE    P     W + DK       G+ +E  P 
Sbjct: 437 TVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPD 496

Query: 277 LSKLIFFNVSEHDYGNYTC 295
             KL    VS    G Y C
Sbjct: 497 -GKLRLERVSRDMSGTYRC 514



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 54/188 (28%), Positives = 80/188 (42%), Gaps = 26/188 (13%)

Query: 39  PKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWC-LDPRVVLLSNTQTQ 97
           PK    VTVR+G  A L+C +  +        R  +L++  DK   L P  + L  T   
Sbjct: 445 PKGRAVVTVREGSPAELQCEVRGKP-------RPPVLWSRVDKEAALLPSGLPLEETPDG 497

Query: 98  YSIEIQNVDVYDEGPYTCSVQTDN----HPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
             + ++ V     G Y C     N     P+ ++V L VQ  P++   S D+    G  +
Sbjct: 498 -KLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPV 556

Query: 154 SLTC-IATGRPE--PTVTWRH---------ISPKAVGFVSEDEYLEIQGITREQSGDYEC 201
            L C +  G P+   +  WR          + P A       E L +  +TR+ SG YEC
Sbjct: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYEC 615

Query: 202 SASNDVAA 209
           S SNDV +
Sbjct: 616 SVSNDVGS 623



 Score = 28.5 bits (62), Expect = 9.2
 Identities = 60/306 (19%), Positives = 104/306 (33%), Gaps = 52/306 (16%)

Query: 31  VRSGDATFPKAMDNV-----TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCL 84
           V +G A   K  DN+     T+R+G++  L+C +      +V W   +    + +DK+  
Sbjct: 30  VHAGQACVVKE-DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAG---SASDKF-- 83

Query: 85  DPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD-NHPKTSRVHLIVQ-VSPKIVEIS 142
                    +    ++ I+ +     G Y C  +     P    + + VQ +   ++ + 
Sbjct: 84  ------QETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVH 137

Query: 143 SDISINEGN-----NISLTCIATGRPEPTVTWR-------HISPKAVGFVS------EDE 184
             +S   GN      + L C     P     W+       H     V          E +
Sbjct: 138 QTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETK 197

Query: 185 YLEIQGITREQSGDYECSAS--NDVAAP----VVRRVKVTVNYPPYISEAKGTGVPVGQK 238
            L+++ +  +    Y C  S  N    P      R    T      +S  +   V  G+ 
Sbjct: 198 VLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGEN 257

Query: 239 GTLQCEASAV-PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVA 297
            T+QC  +   P  + QW      L  G              L   +V   D G Y C A
Sbjct: 258 VTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQG-------GTLSIPSVQARDSGYYNCTA 310

Query: 298 SNKLGH 303
           +N +G+
Sbjct: 311 TNNVGN 316


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 73/270 (27%), Positives = 114/270 (42%), Gaps = 29/270 (10%)

Query: 50  GESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVY 108
           G+  TL C    N V R+ W      L   + +W           T  + +++I +V   
Sbjct: 254 GQQVTLECFAFGNPVPRIKWRKVDGSL---SPQW-----------TTAEPTLQIPSVSFE 299

Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
           DEG Y C  +      T +  +IVQ  P+ +++ SD   + G+N+   C A G+P PTV 
Sbjct: 300 DEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVR 359

Query: 169 W-RHISPKA----VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV-RRVKVTVNYP 222
           W R+  P A    V  ++ D  L    ++ E SG Y+C A N          + V    P
Sbjct: 360 WLRNGEPLASQNRVEVLAGD--LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAP 417

Query: 223 PYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
            +        +P  + G   + C+  A P A   W K  + L+   +     +      L
Sbjct: 418 DFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPD----GTL 473

Query: 281 IFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           I  N+S  D G YTC A N +G  N++ +L
Sbjct: 474 IIRNISRSDEGKYTCFAENFMGKANSTGIL 503



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 2/70 (2%)

Query: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATG 161
           I+N+   DEG YTC  +       S   L V+ + KI    S   IN G+N++L C A+ 
Sbjct: 475 IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASH 534

Query: 162 RP--EPTVTW 169
            P  + T TW
Sbjct: 535 DPTMDLTFTW 544



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 37/169 (21%), Positives = 65/169 (38%), Gaps = 18/169 (10%)

Query: 153 ISLTCIATGRPEPTVTWR------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
           + L C A   P  T  W+       + P +   +     + +     + +G Y+C ASN 
Sbjct: 57  VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116

Query: 207 VAAPVVRRVKVTVNYPPYISEAKGTGVPV--GQKGTLQCEASA-VPSAEFQWYKDDKRLI 263
           V   V R   +   +    S+ +   V    G    L C   A  P   ++W      L 
Sbjct: 117 VGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL-----LN 171

Query: 264 EGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNKLGHTNASI 308
           E    +  + R F+S+    L     +  D GNY+C+A++ +  +  S+
Sbjct: 172 EFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSV 220



 Score = 28.9 bits (63), Expect = 7.0
 Identities = 23/68 (33%), Positives = 28/68 (41%), Gaps = 7/68 (10%)

Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
           VGQ+ TL+C A   P    +W K D  L    +    E       L   +VS  D G Y 
Sbjct: 253 VGQQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAE-----PTLQIPSVSFEDEGTYE 305

Query: 295 CVASNKLG 302
           C A N  G
Sbjct: 306 CEAENSKG 313


>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
          Length = 437

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 95/321 (29%), Positives = 145/321 (45%), Gaps = 32/321 (9%)

Query: 14  LVVVSLRLLFLVPTGVP---VRSGDATFPKAMDNVTVRQGESATLRCTID-NRVTRVAWL 69
           + V+ L  L LVP       V+     FP    NVTV +G +A L C +D N  T + W 
Sbjct: 1   MFVLFLCNLSLVPAAASKNKVKGSQGQFPLTQ-NVTVVEGGTAILTCRVDQNDNTSLQWS 59

Query: 70  NRST-ILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRV 128
           N +   LY  + K   D R+ L+  +  + SI + +V + DEG YTCS+ T    KTS+ 
Sbjct: 60  NPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFT-MPVKTSKA 118

Query: 129 HLIVQVSPKIVEISSDIS-INEGNNISLTCIATG-RPEPTVTW--RHISPKAVGFVSEDE 184
           +L V   P+  +IS   S + EG+ + LTC  +G +P   + W       K V ++ E++
Sbjct: 119 YLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEED 178

Query: 185 YLEIQGITREQSGDYECSASND-------------VAAPVVRRVKVTVNYPPYISEAKGT 231
               +  T   + D+    S+D              A P V    + ++Y P +     T
Sbjct: 179 -ANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPST 237

Query: 232 GVP-VGQKGTLQCEASAVPSAE-FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHD 289
             P  GQ   L CE+   P  E   W KD   L +  + V V  R     ++F N  + D
Sbjct: 238 PFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMV-VSGREL--NILFLN--KTD 292

Query: 290 YGNYTCVASNKLGHTNASIML 310
            G Y C A+N +G ++A  +L
Sbjct: 293 NGTYRCEATNTIGQSSAEYVL 313



 Score = 35.0 bits (79), Expect = 0.098
 Identities = 33/126 (26%), Positives = 50/126 (39%), Gaps = 8/126 (6%)

Query: 105 VDVYDEG-PYTCSVQTDNHPKTSRVH---LIVQVSPKIVEISSDISINEGNNISLTCIAT 160
           VD  D+G    C V  ++   T +V    L +  +P +  I S     EG  + LTC + 
Sbjct: 194 VDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESK 253

Query: 161 GRPEPT-VTWRHIS---PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
           G+P P  V W       P     V     L I  + +  +G Y C A+N +       V 
Sbjct: 254 GKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVL 313

Query: 217 VTVNYP 222
           +  + P
Sbjct: 314 IVHDVP 319


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 64/268 (23%), Positives = 114/268 (42%), Gaps = 25/268 (9%)

Query: 44  NVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           +V    G++ TL C  + N V  + W            +  L+P       + +   ++I
Sbjct: 250 DVYALMGQNVTLECFALGNPVPDIRW------------RKVLEPMPSTAEISTSGAVLKI 297

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
            N+ + DEG Y C  +        +  + VQ  P+ VE  +D  ++ G+++   C+ATG+
Sbjct: 298 FNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGK 357

Query: 163 PEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNY 221
           P PT+ W        G+      L +  +T E +G Y+C A N   A      +K+    
Sbjct: 358 PIPTIRW-----LKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALA 412

Query: 222 PPYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
           P +        +   + G   ++C+  A P  +F W K  + L+   + +  E+      
Sbjct: 413 PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED----GS 468

Query: 280 LIFFNVSEHDYGNYTCVASNKLGHTNAS 307
           L   N++ +D G YTC A N  G  N++
Sbjct: 469 LEINNITRNDGGIYTCFAENNRGKANST 496



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 75/318 (23%), Positives = 126/318 (39%), Gaps = 50/318 (15%)

Query: 31  VRSGDATF---------PKAMDNVTVRQGESATLRCTIDNRVT---RVAWLNRSTILYAG 78
           VRS +AT          P+    V V++G+   L C             WL     ++  
Sbjct: 123 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFIT 182

Query: 79  NDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKT--SRVHLIVQVSP 136
            DK     R V    +QT  ++ I NV+  D+G Y+C V + +  K+  S+   ++ +  
Sbjct: 183 MDK----RRFV----SQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 234

Query: 137 K--------IVEISSDISINEGNNISLTCIATGRPEPTVTWRHI---SPKAVGFVSEDEY 185
           +        IV    D+    G N++L C A G P P + WR +    P      +    
Sbjct: 235 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAV 294

Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-YPPYISEAKGTGVPVGQKGTLQCE 244
           L+I  I  E  G YEC A N +      + ++ V  +P ++     T V +G      C 
Sbjct: 295 LKIFNIQLEDEGIYECEAEN-IRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCV 353

Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG-- 302
           A+  P    +W K+     +G             +L  ++V+  + G Y C+A N  G  
Sbjct: 354 ATGKPIPTIRWLKNGYAYHKG-------------ELRLYDVTFENAGMYQCIAENTYGAI 400

Query: 303 HTNASIMLFGPGAVSEVS 320
           + NA + +       E++
Sbjct: 401 YANAELKILALAPTFEMN 418



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 58/244 (23%), Positives = 98/244 (40%), Gaps = 16/244 (6%)

Query: 86  PRVVLLSNTQTQYSIEIQNVDVYDE--GPYTCSVQTDNHPKTSRVHL-IVQVSP--KIVE 140
           P +  L N    +  E++  DV  E  G Y C  +       +   L I+ ++P  ++  
Sbjct: 360 PTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 419

Query: 141 ISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG----FVSEDEYLEIQGITREQS 196
           +   I   +G  + + C     P+P  +W   +   V      + ED  LEI  ITR   
Sbjct: 420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDG 479

Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQ 254
           G Y C A N+          V  +    I       + VG+  T+QC AS  P+ +  F 
Sbjct: 480 GIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFV 539

Query: 255 WYKDDKRLIEGKKGVKVENRPFL---SKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IM 309
           W  +   +   K+ +  +    L    +L+  N      G YTC A   + +++AS  ++
Sbjct: 540 WSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLV 599

Query: 310 LFGP 313
           + GP
Sbjct: 600 VRGP 603



 Score = 35.4 bits (80), Expect = 0.075
 Identities = 42/166 (25%), Positives = 67/166 (40%), Gaps = 30/166 (18%)

Query: 153 ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASN 205
           +SL C A   P P   WR  +      ++ D Y  + G         ++ +G Y C ASN
Sbjct: 61  VSLNCRARASPFPVYKWRMNNGDV--DLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASN 118

Query: 206 DVAAPVVRRVKVTVN------YPPYISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYK 257
           +    +VR  + T++      +PP   E     V  G+   L C+          ++W  
Sbjct: 119 NYG--MVRSTEATLSFGYLDPFPP--EERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWL- 173

Query: 258 DDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASN 299
               L E    + ++ R F+S+    L   NV   D GNY+C  S+
Sbjct: 174 ----LNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 64/268 (23%), Positives = 114/268 (42%), Gaps = 25/268 (9%)

Query: 44  NVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
           +V    G++ TL C  + N V  + W            +  L+P       + +   ++I
Sbjct: 239 DVYALMGQNVTLECFALGNPVPDIRW------------RKVLEPMPSTAEISTSGAVLKI 286

Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
            N+ + DEG Y C  +        +  + VQ  P+ VE  +D  ++ G+++   C+ATG+
Sbjct: 287 FNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGK 346

Query: 163 PEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNY 221
           P PT+ W        G+      L +  +T E +G Y+C A N   A      +K+    
Sbjct: 347 PIPTIRW-----LKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALA 401

Query: 222 PPYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
           P +        +   + G   ++C+  A P  +F W K  + L+   + +  E+      
Sbjct: 402 PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED----GS 457

Query: 280 LIFFNVSEHDYGNYTCVASNKLGHTNAS 307
           L   N++ +D G YTC A N  G  N++
Sbjct: 458 LEINNITRNDGGIYTCFAENNRGKANST 485



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 75/318 (23%), Positives = 126/318 (39%), Gaps = 50/318 (15%)

Query: 31  VRSGDATF---------PKAMDNVTVRQGESATLRCTIDNRVT---RVAWLNRSTILYAG 78
           VRS +AT          P+    V V++G+   L C             WL     ++  
Sbjct: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFIT 171

Query: 79  NDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKT--SRVHLIVQVSP 136
            DK     R V    +QT  ++ I NV+  D+G Y+C V + +  K+  S+   ++ +  
Sbjct: 172 MDK----RRFV----SQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 223

Query: 137 K--------IVEISSDISINEGNNISLTCIATGRPEPTVTWRHI---SPKAVGFVSEDEY 185
           +        IV    D+    G N++L C A G P P + WR +    P      +    
Sbjct: 224 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAV 283

Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-YPPYISEAKGTGVPVGQKGTLQCE 244
           L+I  I  E  G YEC A N +      + ++ V  +P ++     T V +G      C 
Sbjct: 284 LKIFNIQLEDEGIYECEAEN-IRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCV 342

Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG-- 302
           A+  P    +W K+     +G             +L  ++V+  + G Y C+A N  G  
Sbjct: 343 ATGKPIPTIRWLKNGYAYHKG-------------ELRLYDVTFENAGMYQCIAENTYGAI 389

Query: 303 HTNASIMLFGPGAVSEVS 320
           + NA + +       E++
Sbjct: 390 YANAELKILALAPTFEMN 407



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 58/244 (23%), Positives = 98/244 (40%), Gaps = 16/244 (6%)

Query: 86  PRVVLLSNTQTQYSIEIQNVDVYDE--GPYTCSVQTDNHPKTSRVHL-IVQVSP--KIVE 140
           P +  L N    +  E++  DV  E  G Y C  +       +   L I+ ++P  ++  
Sbjct: 349 PTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 408

Query: 141 ISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG----FVSEDEYLEIQGITREQS 196
           +   I   +G  + + C     P+P  +W   +   V      + ED  LEI  ITR   
Sbjct: 409 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDG 468

Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQ 254
           G Y C A N+          V  +    I       + VG+  T+QC AS  P+ +  F 
Sbjct: 469 GIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFV 528

Query: 255 WYKDDKRLIEGKKGVKVENRPFL---SKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IM 309
           W  +   +   K+ +  +    L    +L+  N      G YTC A   + +++AS  ++
Sbjct: 529 WSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLV 588

Query: 310 LFGP 313
           + GP
Sbjct: 589 VRGP 592



 Score = 35.4 bits (80), Expect = 0.075
 Identities = 42/166 (25%), Positives = 67/166 (40%), Gaps = 30/166 (18%)

Query: 153 ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASN 205
           +SL C A   P P   WR  +      ++ D Y  + G         ++ +G Y C ASN
Sbjct: 50  VSLNCRARASPFPVYKWRMNNGDV--DLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASN 107

Query: 206 DVAAPVVRRVKVTVN------YPPYISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYK 257
           +    +VR  + T++      +PP   E     V  G+   L C+          ++W  
Sbjct: 108 NYG--MVRSTEATLSFGYLDPFPP--EERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWL- 162

Query: 258 DDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASN 299
               L E    + ++ R F+S+    L   NV   D GNY+C  S+
Sbjct: 163 ----LNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 33/289 (11%)

Query: 43  DNVTVRQGESATLRCTI----DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
           + +   +G + TL CT     D+ ++ V W   S ILY  + +  +  R    +    +Y
Sbjct: 505 ETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFV--RYWQQAGEALEY 561

Query: 99  S--IEIQNVDVYDEGPYTCSVQTDNH---PKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
           +  + + NV+  DEG Y C V   NH     + +  L V   P  ++   D++I  G   
Sbjct: 562 TSILHLFNVNFTDEGKYQCIVT--NHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMA 619

Query: 154 SLTCIATGRPEPTVTWRH--------ISPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
            L C A G P P ++W+            + +  + ED+   I  +  E  G Y C A N
Sbjct: 620 RLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQN 679

Query: 206 DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
                        +  P +I   +   V  G+   LQC A   P+    W KDD  L+  
Sbjct: 680 TAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL-- 737

Query: 266 KKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
                V  R F +     LI  +    D G YTC+ SN LG     I L
Sbjct: 738 -----VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYL 781



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 15/176 (8%)

Query: 37  TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNT 94
           +F K   ++T+R G  A L C  +     +++W  +  T   A  ++     R+ ++   
Sbjct: 603 SFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARER-----RMHVMPED 657

Query: 95  QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
              +   I NV + D G Y+C  Q      ++   L V  +P  +    D ++  G    
Sbjct: 658 DVFF---IANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAV 714

Query: 155 LTCIATGRPEPTVTW-RHISPKAVG----FVSEDEYLEIQGITREQSGDYECSASN 205
           L CIA G P P + W +   P  V     F + ++ L I     E +G Y C  SN
Sbjct: 715 LQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSN 770


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            + I +    D G Y C  +        +  L+VQV P I     D+S  EG++  L C A
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870

Query: 160  TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
             G PEP +TW        G      +     L ++ +  + +G Y C+A N V     RR
Sbjct: 2871 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 2929

Query: 215  VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V +T+   P  +   G   + +G +  L+C A   P+    W  +D+ + EG     V  
Sbjct: 2930 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 2984

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
            +   S L    VS  D G Y C A N++G T A
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 3017



 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)

Query: 43   DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            D V VR G+ A L C  D      A    +   Y       L  R   L   Q    +EI
Sbjct: 1849 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 1899

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
            Q   V D+G Y+C V            L VQV P      ++ +S   G+ + LTC  +G
Sbjct: 1900 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 1959

Query: 162  RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
             P PTVTW      +   AV G VS    L++  +   Q+G Y C A N   A   +   
Sbjct: 1960 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 2018

Query: 217  VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V V   P I     A+   V  GQ+  L CEA   P  +  W KD   L +   G  +  
Sbjct: 2019 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 2077

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                  L+   +   D G YTCVA N  G
Sbjct: 2078 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 2106



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)

Query: 21   LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
            LL L P   PV  GD    + ++ VTV    + +L+C  + N V  ++WL          
Sbjct: 1645 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 1693

Query: 80   DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
              +   PR+ +L + Q    +++   +V D   Y C  +           L VQV P+I 
Sbjct: 1694 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1749

Query: 140  EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
             +  + ++    +++SL C     P P VTW   S      + V  +     L++     
Sbjct: 1750 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1809

Query: 194  EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
              SG Y C A N  A    + V+++V  PP   +A         V VG K  L CE  A+
Sbjct: 1810 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1868

Query: 249  PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            P     WYKD + L+  ++   +       +L        D G Y+C  SN  G
Sbjct: 1869 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 1919



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)

Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
           ++I+ VD+ DEG YTC+           V L V V P I     + ++ E  +++L C+A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718

Query: 160 TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
           +G P P V+W    + +S      VS D   L I+      +G Y C ASN VA     R
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 777

Query: 215 VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
             + VN PP I+       P  V     L C A+  PS    W KD   +   G  G++V
Sbjct: 778 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 837

Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              P    L   +    D G Y+CVA + +G     ++L
Sbjct: 838 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 874



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)

Query: 45   VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            + V  G++A L C +      ++ W      L  G D   + P  VLL   Q   S    
Sbjct: 1264 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 1318

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
                   G Y+C        KT    L V ++P I+   E S+D  +++   N ISL C 
Sbjct: 1319 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 1373

Query: 159  ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
            A   P P +TW        + + +  +     L+I    +E +G Y C  +N++    V+
Sbjct: 1374 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 1432

Query: 214  RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
               V V  PP IS+         K     V    TL+CE+ AVP    +WYKD + +   
Sbjct: 1433 NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 1492

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             + ++V     L ++    VS  D G Y CVA+N  G
Sbjct: 1493 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 1526



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            ++EI        G YTCS +         V L VQ SP +  + S +       + L C 
Sbjct: 2720 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 2779

Query: 159  ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            A+G P PT+TW+    +++      V     L I   + E +G+Y C A N  A   + +
Sbjct: 2780 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 2838

Query: 215  VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
             ++ V  PP I           G    L C+A   P     W KD +  + G +G K   
Sbjct: 2839 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 2896

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +P   +L+  N+   D G YTC A N +G     + L
Sbjct: 2897 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2932



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)

Query: 48   RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
            R GE  T+ C +  +    V+WL     L        L  R +L  +  T   + I  V 
Sbjct: 2135 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 2184

Query: 107  VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
            + D G +TC   +          L VQV P +  VE  +D+ +  G+ + L C A G P 
Sbjct: 2185 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244

Query: 165  PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            P V+W +   P     + +   L+++ +    SG Y C A ++ A    R  ++TV  PP
Sbjct: 2245 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 2303

Query: 224  YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
            +I ++       +  G    L C+A   P     W+KD + L       ++EN    +++
Sbjct: 2304 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 2357

Query: 281  IFFNVSEHDYGNYTCVASNKLG 302
            +       D G YTC+A +  G
Sbjct: 2358 L----RVRDAGLYTCLAESPAG 2375



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)

Query: 42   MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
            + N+T       TL C  +      + W      +  G D + L     +L  TQTQ   
Sbjct: 1168 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 1225

Query: 101  EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
                    D G Y+C    +         + V V P I   ++   I + +G    L C 
Sbjct: 1226 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277

Query: 159  ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
             TG P+P +TW             HISP  V        L++       +G Y C A+N 
Sbjct: 1278 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 1330

Query: 207  VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            V     +  +++V   P I      S  +   V V    +L CEA A PS    W KD  
Sbjct: 1331 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389

Query: 261  RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
               E  + +++   P    L   N  + D G YTCV +N+LG    N  + +  P ++S+
Sbjct: 1390 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1446



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)

Query: 82   WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
            W  D   +L  + +   S++++ V   D G Y+C   ++         L V   P I + 
Sbjct: 2249 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308

Query: 142  S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
               +++S+  G  + L C A G P+P +TW H   +A+  + E+     + +    +G Y
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 2366

Query: 200  ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
             C A +   A + +  +V V  PP I   +G     G+  GQ   L+C   A P+ +  W
Sbjct: 2367 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 2424

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
            ++D   L E       E   FL       +S  D G+Y+C A N  G T+ +  +     
Sbjct: 2425 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2481

Query: 311  ----FGPGAVSEVSNGTS 324
                 GP AV+   N T+
Sbjct: 2482 PTIRSGPPAVNVSVNQTA 2499



 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D   + C V  +         + V V P I +  +D ++     + LTC +TG P PTV+
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698

Query: 169  W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            W      +  +  G+ VS    LEI       +G Y CSA N  A    + V +TV   P
Sbjct: 2699 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 2757

Query: 224  YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
             +         V ++   L CEAS +P     W K+    +    GV  +  P   +L  
Sbjct: 2758 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 2813

Query: 283  FNVSEHDYGNYTCVASNKLG 302
             + S  D GNY C+A N  G
Sbjct: 2814 AHASPEDAGNYLCIAKNSAG 2833



 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)

Query: 110  EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
            EG YTC         +  + L V V P+I    E  + +S+ +    +L C ATG+P PT
Sbjct: 1039 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1098

Query: 167  VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
            VTW     + VG        ++ + L ++      +G Y C A N +A    R+ +++V 
Sbjct: 1099 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 1156

Query: 221  YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
             PP     +         +    TL CEA  +P    +W++ ++ +  G+    +     
Sbjct: 1157 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1216

Query: 277  LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
            L         E D G Y+C+ASN+ G    N S+ +  P ++
Sbjct: 1217 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1255



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)

Query: 79  NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
           N  W  D   +L ++T+  Y+     +++      D G YTC              L V 
Sbjct: 342 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 400

Query: 134 VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
           V P I         +    G  ++L C+A G P PT++W H              ++   
Sbjct: 401 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 460

Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
           L ++      SG Y C AS+  A   V +  V V  PP +  A+G G     VGQ   L 
Sbjct: 461 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 519

Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
           C+AS  P    QW ++  R  E   GV+V ++   + L   +V     G + C A+N+ G
Sbjct: 520 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 576

Query: 303 HTNASI 308
              A +
Sbjct: 577 TAGAEV 582



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 16/223 (7%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
            +++   DV+D G YTC             +L V V+P   +  S  +++ EG+  SL+C 
Sbjct: 935  LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 994

Query: 159  ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
              G P P ++WR       G  +  +++   G           Q G Y C  SN V    
Sbjct: 995  CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 1053

Query: 212  VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
             + +++ V+ PP I+  +   T V V Q G  TL+C A+  P     W +D +  +  + 
Sbjct: 1054 SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 1112

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            G++++N+     L          G Y+CVA N  G       L
Sbjct: 1113 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1153



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
            ++I  V   + G Y+C    +         L+V   P I+    E+  ++++N  + +SL
Sbjct: 1615 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1674

Query: 156  TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
             C A G P PT++W       SP     V ED + L++       +  Y C A N  A  
Sbjct: 1675 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 1733

Query: 211  VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              +   + V  PP I+  + +     +    +L C+  A P+ E  WYKD + L     G
Sbjct: 1734 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 1790

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +V   P    L        D G YTC A N  G     + L
Sbjct: 1791 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1832



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)

Query: 88   VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
            +VL  +  TQ+      +++Q +   D G Y+C+ +      +    + +   P I    
Sbjct: 2429 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 2488

Query: 143  SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
              ++++      L C A G P P V+WR     + P++  F +  +  L IQ +  + +G
Sbjct: 2489 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2548

Query: 198  DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
             Y C ASN   +    R    +  P          +       L CEAS  P     W+K
Sbjct: 2549 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 2608

Query: 258  D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
            D    D RL +G   +   N      L+       D   + CV SN++G  +
Sbjct: 2609 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 2655



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 37/238 (15%)

Query: 98   YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-------SDISINEG 150
            + ++I N    D G YTC V  +        H+ V + P I +          ++     
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463

Query: 151  NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
            + ++L C +   P PT+ W    + ++P + +  + E   L+IQ      SG Y C A+N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 206  DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
             VA    +   V +  PP                   EA+G       +       L C+
Sbjct: 1524 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582

Query: 245  ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +A+P  +  WY++D+ L  G +   ++    L   +   V   + G Y+C ASN++G
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 1637



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 43/114 (37%), Positives = 57/114 (50%), Gaps = 16/114 (14%)

Query: 157 CIATGRPEPTVTWR--------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
           C   G P+P VTWR        H  P     V E+  L +  ++   SGDYEC A+N+V 
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVA--VLEEGSLFLASVSPADSGDYECQATNEVG 81

Query: 209 APVVRRVKVTVNYPPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQWYKD 258
           +   RR K+ V  PP I E    A  +G+  GQ  TL+C+A+  P  E  W KD
Sbjct: 82  S-TSRRAKLVVYVPPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIVWLKD 133



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 11/210 (5%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D G Y+C   +        V L V + P I+    ++S+    +++L C +   P P ++
Sbjct: 853  DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 912

Query: 169  W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            W    R + P+    +S D+  L++       +G Y C A N  A    +   + V   P
Sbjct: 913  WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGRSEKHYNLNVWVAP 971

Query: 224  Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
               + E+    V  G   +L CE   VP  +  W KD + L    +G  +++   + +L+
Sbjct: 972  VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 1029

Query: 282  FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
            +   ++    G YTC  SN +G+++  + L
Sbjct: 1030 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)

Query: 81  KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
           +W  D + VL      Q       + I    V DEG Y C   +    +     L V   
Sbjct: 250 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 309

Query: 136 PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
           P I     + ++++ E + + L C A G P P +TW         S K V +      L+
Sbjct: 310 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 368

Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
           +       +G Y C ASN V A   +  ++ V  PP I  A G    V    G+   L+C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 427

Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            A   PS    W+ +   + E  +  ++E     S L   +  E   G Y+CVAS+  G
Sbjct: 428 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 483



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)

Query: 25   VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
            VPT   +RSG    P A+ NV+V Q  +A L C  D      V+W           D+  
Sbjct: 2481 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 2521

Query: 84   LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
            LDPR         + S+ IQ V   D G Y C              L V   P I    S
Sbjct: 2522 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2580

Query: 144  DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
            ++++       L C A+G P+P V W     K    + +  Y       L +     + S
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 2640

Query: 197  GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
              +EC  SN+V     R  +VTV+ PP I++ +    V +     L C ++ +P+    W
Sbjct: 2641 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2699

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K   +L  G +G      P  +  I   +  H  G YTC A N  G  +  + L
Sbjct: 2700 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 2751



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 24/272 (8%)

Query: 46   TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            ++R G+   LRC      T R+ W          ND+    P    +S      +++   
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 2995

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
            V   D G Y C  + +   +T  V  + V+ +P +  E  S +    G +I L C+  G 
Sbjct: 2996 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 3054

Query: 163  PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
            P P + W      +    +    ++  L I    R+ +G Y+C A N++       + V 
Sbjct: 3055 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 3114

Query: 219  VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
             + P +  E +   V  G    L+C+A+  P+   +W +  + L   ++   + +     
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 3170

Query: 279  KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             L   NV   D G Y CVA N LG   A   L
Sbjct: 3171 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 3202



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 52/162 (32%), Positives = 69/162 (42%), Gaps = 13/162 (8%)

Query: 150 GNNISLTCIATGRPEPTVTW-RHISPKAVG----FVSED-EYLEIQGITREQSGDYECSA 203
           G ++ L C  +G P P V W +   P   G     V ED + L I G      G Y+C A
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291

Query: 204 SNDVAAPVVRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQ--CEASAVPSAEFQWYKDDK 260
            +  A    R  ++ V+ PP I  +  TG V V +   +Q  CEA  VP+    W+KD  
Sbjct: 292 FSP-AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 350

Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            L    K V         +L        D G YTC ASN +G
Sbjct: 351 LLPTSTKVVYTRGG---RQLQLGRAQSSDAGVYTCKASNAVG 389



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 5/144 (3%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+ I   +  D G Y C  + +       V L++Q +P       D+++  G++++L C 
Sbjct: 3081 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3140

Query: 159  ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            ATG P PT+ W                 D  L ++ +    +G Y+C A N + +   R 
Sbjct: 3141 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3200

Query: 215  VKVTVNYPPYISEAKGTGVPVGQK 238
              V V   P  S    TGV  G+K
Sbjct: 3201 FLV-VRGEPQGSWGSMTGVINGRK 3223



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 56/242 (23%), Positives = 90/242 (37%), Gaps = 41/242 (16%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE--ISSDISINEGNNISLT 156
           S+ + +V   D G Y C    +    + R  L+V V P I E    +++S   G +++L 
Sbjct: 58  SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 117

Query: 157 CIATGRPEPTVTWRHISPKAVG---------------------FVSEDEYLEIQGITREQ 195
           C A G P P + W     + VG                      + E + L    I   +
Sbjct: 118 CDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGR 176

Query: 196 SG--DYECSASNDVAAPVVRRVKVTVNY-------PPYISEAKGTGVP------VGQKGT 240
           SG    +   S    AP    +     +       PP      G G         G    
Sbjct: 177 SGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVE 236

Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
           LQC  S VP+ + +W KD + ++ G   ++V+    + ++   +V   D G Y CVA + 
Sbjct: 237 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSP 294

Query: 301 LG 302
            G
Sbjct: 295 AG 296



 Score = 35.4 bits (80), Expect = 0.075
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)

Query: 17   VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
            V+ +++ LV    PV      F     ++TVR G+   LRC      T  + WL     L
Sbjct: 3105 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158

Query: 76   YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
             A                T    S+ ++NV+  D G Y C         T+R  L+V+  
Sbjct: 3159 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 3207

Query: 136  PK 137
            P+
Sbjct: 3208 PQ 3209



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 6/79 (7%)

Query: 243 CEASAVPSAEFQWYKD-DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
           C     P  +  W K      + G+ GV V        L   +VS  D G+Y C A+N++
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEE---GSLFLASVSPADSGDYECQATNEV 80

Query: 302 GHTN--ASIMLFGPGAVSE 318
           G T+  A ++++ P ++ E
Sbjct: 81  GSTSRRAKLVVYVPPSIRE 99


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
            + I +    D G Y C  +        +  L+VQV P I     D+S  EG++  L C A
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779

Query: 160  TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
             G PEP +TW        G      +     L ++ +  + +G Y C+A N V     RR
Sbjct: 2780 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 2838

Query: 215  VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V +T+   P  +   G   + +G +  L+C A   P+    W  +D+ + EG     V  
Sbjct: 2839 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 2893

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
            +   S L    VS  D G Y C A N++G T A
Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 2926



 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)

Query: 43   DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
            D V VR G+ A L C  D      A    +   Y       L  R   L   Q    +EI
Sbjct: 1758 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 1808

Query: 103  QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
            Q   V D+G Y+C V            L VQV P      ++ +S   G+ + LTC  +G
Sbjct: 1809 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 1868

Query: 162  RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
             P PTVTW      +   AV G VS    L++  +   Q+G Y C A N   A   +   
Sbjct: 1869 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 1927

Query: 217  VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
            V V   P I     A+   V  GQ+  L CEA   P  +  W KD   L +   G  +  
Sbjct: 1928 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 1986

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                  L+   +   D G YTCVA N  G
Sbjct: 1987 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 2015



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)

Query: 21   LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
            LL L P   PV  GD    + ++ VTV    + +L+C  + N V  ++WL          
Sbjct: 1554 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 1602

Query: 80   DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
              +   PR+ +L + Q    +++   +V D   Y C  +           L VQV P+I 
Sbjct: 1603 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1658

Query: 140  EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
             +  + ++    +++SL C     P P VTW   S      + V  +     L++     
Sbjct: 1659 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1718

Query: 194  EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
              SG Y C A N  A    + V+++V  PP   +A         V VG K  L CE  A+
Sbjct: 1719 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1777

Query: 249  PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            P     WYKD + L+  ++   +       +L        D G Y+C  SN  G
Sbjct: 1778 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 1828



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)

Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
           ++I+ VD+ DEG YTC+           V L V V P I     + ++ E  +++L C+A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627

Query: 160 TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
           +G P P V+W    + +S      VS D   L I+      +G Y C ASN VA     R
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 686

Query: 215 VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
             + VN PP I+       P  V     L C A+  PS    W KD   +   G  G++V
Sbjct: 687 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 746

Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
              P    L   +    D G Y+CVA + +G     ++L
Sbjct: 747 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 783



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)

Query: 45   VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
            + V  G++A L C +      ++ W      L  G D   + P  VLL   Q   S    
Sbjct: 1173 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 1227

Query: 104  NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
                   G Y+C        KT    L V ++P I+   E S+D  +++   N ISL C 
Sbjct: 1228 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 1282

Query: 159  ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
            A   P P +TW        + + +  +     L+I    +E +G Y C  +N++    V+
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 1341

Query: 214  RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
               V V  PP IS+         K     V    TL+CE+ AVP    +WYKD + +   
Sbjct: 1342 NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 1401

Query: 266  KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             + ++V     L ++    VS  D G Y CVA+N  G
Sbjct: 1402 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 1435



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            ++EI        G YTCS +         V L VQ SP +  + S +       + L C 
Sbjct: 2629 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 2688

Query: 159  ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            A+G P PT+TW+    +++      V     L I   + E +G+Y C A N  A   + +
Sbjct: 2689 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 2747

Query: 215  VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
             ++ V  PP I           G    L C+A   P     W KD +  + G +G K   
Sbjct: 2748 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 2805

Query: 274  RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            +P   +L+  N+   D G YTC A N +G     + L
Sbjct: 2806 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2841



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)

Query: 48   RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
            R GE  T+ C +  +    V+WL     L        L  R +L  +  T   + I  V 
Sbjct: 2044 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 2093

Query: 107  VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
            + D G +TC   +          L VQV P +  VE  +D+ +  G+ + L C A G P 
Sbjct: 2094 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153

Query: 165  PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            P V+W +   P     + +   L+++ +    SG Y C A ++ A    R  ++TV  PP
Sbjct: 2154 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 2212

Query: 224  YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
            +I ++       +  G    L C+A   P     W+KD + L       ++EN    +++
Sbjct: 2213 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 2266

Query: 281  IFFNVSEHDYGNYTCVASNKLG 302
            +       D G YTC+A +  G
Sbjct: 2267 L----RVRDAGLYTCLAESPAG 2284



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)

Query: 42   MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
            + N+T       TL C  +      + W      +  G D + L     +L  TQTQ   
Sbjct: 1077 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 1134

Query: 101  EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
                    D G Y+C    +         + V V P I   ++   I + +G    L C 
Sbjct: 1135 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186

Query: 159  ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
             TG P+P +TW             HISP  V        L++       +G Y C A+N 
Sbjct: 1187 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 1239

Query: 207  VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
            V     +  +++V   P I      S  +   V V    +L CEA A PS    W KD  
Sbjct: 1240 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298

Query: 261  RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
               E  + +++   P    L   N  + D G YTCV +N+LG    N  + +  P ++S+
Sbjct: 1299 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1355



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)

Query: 82   WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
            W  D   +L  + +   S++++ V   D G Y+C   ++         L V   P I + 
Sbjct: 2158 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217

Query: 142  S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
               +++S+  G  + L C A G P+P +TW H   +A+  + E+     + +    +G Y
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 2275

Query: 200  ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
             C A +   A + +  +V V  PP I   +G     G+  GQ   L+C   A P+ +  W
Sbjct: 2276 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 2333

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
            ++D   L E       E   FL       +S  D G+Y+C A N  G T+ +  +     
Sbjct: 2334 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2390

Query: 311  ----FGPGAVSEVSNGTS 324
                 GP AV+   N T+
Sbjct: 2391 PTIRSGPPAVNVSVNQTA 2408



 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)

Query: 109  DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
            D   + C V  +         + V V P I +  +D ++     + LTC +TG P PTV+
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607

Query: 169  W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            W      +  +  G+ VS    LEI       +G Y CSA N  A    + V +TV   P
Sbjct: 2608 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 2666

Query: 224  YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
             +         V ++   L CEAS +P     W K+    +    GV  +  P   +L  
Sbjct: 2667 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 2722

Query: 283  FNVSEHDYGNYTCVASNKLG 302
             + S  D GNY C+A N  G
Sbjct: 2723 AHASPEDAGNYLCIAKNSAG 2742



 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)

Query: 110  EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
            EG YTC         +  + L V V P+I    E  + +S+ +    +L C ATG+P PT
Sbjct: 948  EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1007

Query: 167  VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
            VTW     + VG        ++ + L ++      +G Y C A N +A    R+ +++V 
Sbjct: 1008 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 1065

Query: 221  YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
             PP     +         +    TL CEA  +P    +W++ ++ +  G+    +     
Sbjct: 1066 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1125

Query: 277  LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
            L         E D G Y+C+ASN+ G    N S+ +  P ++
Sbjct: 1126 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1164



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)

Query: 79  NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
           N  W  D   +L ++T+  Y+     +++      D G YTC              L V 
Sbjct: 251 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309

Query: 134 VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
           V P I         +    G  ++L C+A G P PT++W H              ++   
Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 369

Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
           L ++      SG Y C AS+  A   V +  V V  PP +  A+G G     VGQ   L 
Sbjct: 370 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 428

Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
           C+AS  P    QW ++  R  E   GV+V ++   + L   +V     G + C A+N+ G
Sbjct: 429 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 485

Query: 303 HTNASI 308
              A +
Sbjct: 486 TAGAEV 491



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
            ++I  V   + G Y+C    +         L+V   P I+    E+  ++++N  + +SL
Sbjct: 1524 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1583

Query: 156  TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
             C A G P PT++W       SP     V ED + L++       +  Y C A N  A  
Sbjct: 1584 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 1642

Query: 211  VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
              +   + V  PP I+  + +     +    +L C+  A P+ E  WYKD + L     G
Sbjct: 1643 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 1699

Query: 269  VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             +V   P    L        D G YTC A N  G     + L
Sbjct: 1700 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1741



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 76/279 (27%), Positives = 111/279 (39%), Gaps = 27/279 (9%)

Query: 44  NVTVRQGESATLRCTIDN-RVTRVAWLNRSTIL--------YAGNDKWCLDPRVVLLSNT 94
           NV+   G+S TL C  +   V  + WL  + ++        Y  +  W       LL   
Sbjct: 27  NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86

Query: 95  QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNN 152
           Q   S+    +   D G Y+C  +          HL+V   P ++    + ++    G +
Sbjct: 87  Q---SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD 143

Query: 153 ISLTCIATGRPEPTVTW-RHISPKAVG----FVSED-EYLEIQGITREQSGDYECSASND 206
           + L C  +G P P V W +   P   G     V ED + L I G      G Y+C A + 
Sbjct: 144 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 203

Query: 207 VAAPVVRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQ--CEASAVPSAEFQWYKDDKRLI 263
            A    R  ++ V+ PP I  +  TG V V +   +Q  CEA  VP+    W+KD   L 
Sbjct: 204 -AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 262

Query: 264 EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
              K V         +L        D G YTC ASN +G
Sbjct: 263 TSTKVVYTRGG---RQLQLGRAQSSDAGVYTCKASNAVG 298



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 57/223 (25%), Positives = 94/223 (42%), Gaps = 16/223 (7%)

Query: 100  IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
            +++   DV+D G YTC             +L V V+P   +  S  +++ EG+   L+C 
Sbjct: 844  LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCE 903

Query: 159  ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
              G P P ++WR       G  +  +++   G           Q G Y C  SN V    
Sbjct: 904  CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 962

Query: 212  VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
             + +++ V+ PP I+  +   T V V Q G  TL+C A+  P     W +D +  +  + 
Sbjct: 963  SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 1021

Query: 268  GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
            G++++N+     L          G Y+CVA N  G       L
Sbjct: 1022 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1062



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)

Query: 88   VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
            +VL  +  TQ+      +++Q +   D G Y+C+ +      +    + +   P I    
Sbjct: 2338 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 2397

Query: 143  SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
              ++++      L C A G P P V+WR     + P++  F +  +  L IQ +  + +G
Sbjct: 2398 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2457

Query: 198  DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
             Y C ASN   +    R    +  P          +       L CEAS  P     W+K
Sbjct: 2458 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 2517

Query: 258  D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
            D    D RL +G   +   N      L+       D   + CV SN++G  +
Sbjct: 2518 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 2564



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 56/238 (23%), Positives = 99/238 (41%), Gaps = 37/238 (15%)

Query: 98   YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS--SDISINE-----G 150
            + ++I N    D G YTC V  +        H+ V + P I +    +++ + E      
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372

Query: 151  NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
            + ++L C +   P PT+ W    + ++P + +  + E   L+IQ      SG Y C A+N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432

Query: 206  DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
             VA    +   V +  PP                   EA+G       +       L C+
Sbjct: 1433 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491

Query: 245  ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
             +A+P  +  WY++D+ L  G +   ++    L   +   V   + G Y+C ASN++G
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 1546



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)

Query: 81  KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
           +W  D + VL      Q       + I    V DEG Y C   +    +     L V   
Sbjct: 159 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 218

Query: 136 PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
           P I     + ++++ E + + L C A G P P +TW         S K V +      L+
Sbjct: 219 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 277

Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
           +       +G Y C ASN V A   +  ++ V  PP I  A G    V    G+   L+C
Sbjct: 278 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 336

Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
            A   PS    W+ +   + E  +  ++E     S L   +  E   G Y+CVAS+  G
Sbjct: 337 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 392



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 50/210 (23%), Positives = 91/210 (43%), Gaps = 11/210 (5%)

Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
           D G Y+C   +        V L V + P I+    ++S+    +++L C +   P P ++
Sbjct: 762 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821

Query: 169 W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
           W    R + P+    +S D+  L++       +G Y C A N  A    +   + V   P
Sbjct: 822 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVWVAP 880

Query: 224 Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
              + E+    V  G    L CE   VP  +  W KD + L    +G  +++   + +L+
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 938

Query: 282 FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
           +   ++    G YTC  SN +G+++  + L
Sbjct: 939 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 968



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)

Query: 25   VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
            VPT   +RSG    P A+ NV+V Q  +A L C  D      V+W           D+  
Sbjct: 2390 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 2430

Query: 84   LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
            LDPR         + S+ IQ V   D G Y C              L V   P I    S
Sbjct: 2431 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489

Query: 144  DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
            ++++       L C A+G P+P V W     K    + +  Y       L +     + S
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 2549

Query: 197  GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
              +EC  SN+V     R  +VTV+ PP I++ +    V +     L C ++ +P+    W
Sbjct: 2550 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2608

Query: 256  YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             K   +L  G +G      P  +  I   +  H  G YTC A N  G  +  + L
Sbjct: 2609 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 2660



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 64/272 (23%), Positives = 109/272 (40%), Gaps = 24/272 (8%)

Query: 46   TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
            ++R G+   LRC      T R+ W          ND+    P    +S      +++   
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 2904

Query: 105  VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
            V   D G Y C  + +   +T  V  + V+ +P +  E  S +    G +I L C+  G 
Sbjct: 2905 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 2963

Query: 163  PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
            P P + W      +    +    ++  L I+   R+ +G Y+C A N++       + V 
Sbjct: 2964 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVL 3023

Query: 219  VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
             + P +  E +   V  G    L+C+A+  P+   +W +  + L   ++   + +     
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 3079

Query: 279  KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
             L   NV   D G Y CVA N LG   A   L
Sbjct: 3080 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 3111



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 5/144 (3%)

Query: 99   SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
            S+ I+  +  D G Y C  + +       V L++Q +P       D+++  G++++L C 
Sbjct: 2990 SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3049

Query: 159  ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
            ATG P PT+ W                 D  L ++ +    +G Y+C A N + +   R 
Sbjct: 3050 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3109

Query: 215  VKVTVNYPPYISEAKGTGVPVGQK 238
              V V   P  S    TGV  G+K
Sbjct: 3110 FLV-VRGEPQGSWGSMTGVINGRK 3132



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 28/184 (15%)

Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG---------------------FVS 181
           +++S   G +++L C A G P P + W     + VG                      + 
Sbjct: 26  ANVSGMAGQSLTLECDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLD 84

Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT- 240
           E + L    I    SG Y C A N  A    R   + V  PP +  A      +G  G  
Sbjct: 85  EGQSLHFPRIQEGDSGLYSCRAENQ-AGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD 143

Query: 241 --LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVAS 298
             LQC  S VP+ + +W KD + ++ G   ++V+    + ++   +V   D G Y CVA 
Sbjct: 144 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAF 201

Query: 299 NKLG 302
           +  G
Sbjct: 202 SPAG 205



 Score = 35.4 bits (80), Expect = 0.075
 Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)

Query: 17   VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
            V+ +++ LV    PV      F     ++TVR G+   LRC      T  + WL     L
Sbjct: 3014 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3067

Query: 76   YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
             A                T    S+ ++NV+  D G Y C         T+R  L+V+  
Sbjct: 3068 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 3116

Query: 136  PK 137
            P+
Sbjct: 3117 PQ 3118



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 37/123 (30%), Positives = 49/123 (39%), Gaps = 27/123 (21%)

Query: 222 PPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG--------- 268
           PP I E    A  +G+  GQ  TL+C+A+  P  E  W K D +L+    G         
Sbjct: 16  PPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLG 73

Query: 269 -VKVENRPFLSK---LIFFNVSEHDYGNYTCVASNKLGHTNASIML--------FGPGAV 316
             +V     L +   L F  + E D G Y+C A N+ G       L         G GA 
Sbjct: 74  WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 133

Query: 317 SEV 319
            EV
Sbjct: 134 QEV 136


>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
          Length = 956

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 30/273 (10%)

Query: 55  LRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPY 113
           LRC  + N   R +W     +L  G+DK  ++      +  +T+  ++++N+   D   Y
Sbjct: 157 LRCVANSNPPVRYSWRRGQEVLLQGSDKG-VEIYEPFFTQGETKI-LKLKNLRPQDYANY 214

Query: 114 TCSVQTDNHPKTSRVHLIVQVSPKIVE------ISSDISINEGNNISLTCIATG-RPEPT 166
           +C     N        +  ++S K         +   I +N G  I+L C+ TG  P P+
Sbjct: 215 SCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPS 274

Query: 167 VTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP-------VVRRVK-- 216
           +TW R         V     L I  IT + +G Y C A+N+V  P       +VR +K  
Sbjct: 275 LTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334

Query: 217 -VTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQWYKDDKRLIEGKKGVKVEN 273
              +   PY    K   + +G++  + C+  AVPS E  F W+K+ + L   ++ V  + 
Sbjct: 335 RFWITPDPY---HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQT 391

Query: 274 RPFLS----KLIFFNVSEHDYGNYTCVASNKLG 302
            P +S     L   ++   D+G YTCVAS K G
Sbjct: 392 DPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 424



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 51/170 (30%), Positives = 82/170 (48%), Gaps = 18/170 (10%)

Query: 146 SINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSE----DEYLEIQGITREQSGDYEC 201
           +I EG  + LTC+ TG P P + W   +  A     +    +E L I  I R Q G Y C
Sbjct: 51  TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110

Query: 202 SASNDVAAPVVRRVKVTVNY--PPYISEAKGTGVPVGQ-----KGTLQCEASAVPSAEFQ 254
            A N + +P ++ ++V V Y   P ++  +  G    Q        L+C A++ P   + 
Sbjct: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYS 170

Query: 255 WYKDDKRLIEGK-KGVKVENRPFLSK-----LIFFNVSEHDYGNYTCVAS 298
           W +  + L++G  KGV++   PF ++     L   N+   DY NY+C+AS
Sbjct: 171 WRRGQEVLLQGSDKGVEI-YEPFFTQGETKILKLKNLRPQDYANYSCIAS 219



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 60/241 (24%), Positives = 102/241 (42%), Gaps = 28/241 (11%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV-------EISSDISINEGN 151
           +++I ++   D G YTC V +      S + + V +S   V       +  S +   EG+
Sbjct: 401 NLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459

Query: 152 NISLTCIATGRPEPTVTWRHISPK------AVGFVSEDEYLEIQGITREQSGDYECSASN 205
            I L C  TG+P+P + W     +      ++   S D  L I  ++RE SG Y C  S 
Sbjct: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519

Query: 206 DVAAPVVRR---VKVTVNYPPYISEAKGTGVPVGQ--KGTLQC---EASAVPSAEFQWYK 257
                V  R   V++ V YPP + E     +  GQ    T+ C    A  +    ++W  
Sbjct: 520 YNGFNVKPREALVQLIVQYPPAV-EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL 578

Query: 258 DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
            +K L  G    + +++ + ++    ++S  +YG Y C   N+ G    S ++ G     
Sbjct: 579 GNKLLRTG----QFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAP 633

Query: 318 E 318
           E
Sbjct: 634 E 634



 Score = 32.0 bits (71), Expect = 0.83
 Identities = 57/302 (18%), Positives = 108/302 (35%), Gaps = 78/302 (25%)

Query: 46  TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
           T+R+GE+  L C +      ++ W   +    + +D++          ++    ++ I N
Sbjct: 51  TIREGETLELTCLVTGHPRPQIRWTKTAG---SASDRF--------QDSSVFNETLRITN 99

Query: 105 VDVYDEGPYTCSVQTD-NHP--KTSRVHLIVQVSPKIVEISSDISINEG----NNISLTC 157
           +  +  G Y C  +     P  K+ RV +     P +    S     E       + L C
Sbjct: 100 IQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRC 159

Query: 158 IATGRPEPTVTWRHI-------SPKAVGFVS------EDEYLEIQGITREQSGDYECSAS 204
           +A   P    +WR         S K V          E + L+++ +  +   +Y C AS
Sbjct: 160 VANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIAS 219

Query: 205 -----------------NDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASA 247
                            N  A+P    +K+ V+ P  ++         G+  TL C  + 
Sbjct: 220 VRNVCNIPDKMVSFRLSNKTASP---SIKLLVDDPIVVNP--------GEAITLVCVTTG 268

Query: 248 -VPSAEFQWYKD-----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
             P+    W +      +K ++ G              L    ++  D G Y+C+A+N +
Sbjct: 269 GEPAPSLTWVRSFGTLPEKTVLNG------------GTLTIPAITSDDAGTYSCIANNNV 316

Query: 302 GH 303
           G+
Sbjct: 317 GN 318


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
           precursor [Homo sapiens]
          Length = 2012

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 66/238 (27%), Positives = 94/238 (39%), Gaps = 16/238 (6%)

Query: 89  VLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN 148
           V + N     S+ I N+ +   G YTC  + +      +  LIV+V PK V    D    
Sbjct: 643 VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGI 702

Query: 149 EGNNISLTCIATGRPEPTVTWR--------HISPKAVG---FVSEDEYLEIQGITREQSG 197
            G  + L C A G P PT+ W+           P A+     V  +  L I+ +  E SG
Sbjct: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762

Query: 198 DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV-GQKGTLQCEASAVPSAEFQWY 256
            Y C  SNDV A V + + +TV  P  I+    T +   GQK  + C A        +W 
Sbjct: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822

Query: 257 KDDK----RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
           K+D+     +       K      +S L        D G ++C A N  G     I L
Sbjct: 823 KEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQL 880



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 67/282 (23%), Positives = 109/282 (38%), Gaps = 17/282 (6%)

Query: 29  VPVRSGDATFPKAMDNVTVRQGESATLRCTIDNR-VTRVAW-LNRSTILYAGNDKWCLDP 86
           V +  G      A     V   E  +L C +    +  + W L+   IL  G+ +     
Sbjct: 400 VVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ-- 457

Query: 87  RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS 146
             ++ S       + I +  V D G Y C+          +  + V+  P  +    +I+
Sbjct: 458 --MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKNIT 514

Query: 147 INEGNNISLTCIATGRPEPTVTWRHISP------KAVGFVSEDEYLEIQGITRE-QSGDY 199
              G +  + C   G P  ++ W   S       + V F +    L++  + +E   G+Y
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGT-LKLSDVQKEVDEGEY 573

Query: 200 ECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEA-SAVPSAEFQWYKD 258
            C+          + V VTV  PP+I   +     +GQ+  + C   S        W KD
Sbjct: 574 TCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633

Query: 259 DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
             R I G  GV ++N  F S L   N+S    GNYTC+A N+
Sbjct: 634 G-RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE 674



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 75/277 (27%), Positives = 112/277 (40%), Gaps = 34/277 (12%)

Query: 43  DNVTVRQGESATLRCTIDNRV----TRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
           D  T+R G  A  +C I + V    T V+W   +  L +G+          L+++T   Y
Sbjct: 132 DQKTMR-GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSR--------FLITSTGALY 182

Query: 99  SIEIQNVD-VYDEGPYTCSVQTDNHPKTSRVHLIVQ----VSPKIVEISSDISINEGNNI 153
             ++QN D +Y+    T    T    +++   L V      +P I++         G  +
Sbjct: 183 IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRV 242

Query: 154 SLTCIATGRPEPTVTW-RHISPKAVG--FVSEDEYLEIQGITREQSGDYECSASNDV-AA 209
            L C A G PEP   W +   P  +   F      L I+ I    SG Y C  SN    A
Sbjct: 243 ELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTA 302

Query: 210 PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK-- 267
            V+ R+ V       IS  K     VG + +L C  +     E  WY++ + L  GK   
Sbjct: 303 KVIGRLYVKQPLKATISPRK-VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVR 361

Query: 268 --GVKVENRPFLSKLIFFNVSEHDYGNYTC-VASNKL 301
             G+  EN      LI  ++ + D G Y C V  +KL
Sbjct: 362 ITGINHEN------LIMDHMVKSDGGAYQCFVRKDKL 392



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 5/67 (7%)

Query: 236 GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
           GQ+  L C+A   P  +++W KD+  L    +  K      ++ L+  N+   D G+Y C
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT-----VTGLLIENIRPSDSGSYVC 293

Query: 296 VASNKLG 302
             SN+ G
Sbjct: 294 EVSNRYG 300



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 9/111 (8%)

Query: 121  NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
            N  +   V  + +   +I+  S  ++     +I L C A G P P V W   S      V
Sbjct: 1271 NSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV 1330

Query: 181  SEDEYLE--------IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
            + D            I+ +  E SG Y C A+N+  +  +  + + V  PP
Sbjct: 1331 TIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI-ILNLQVQVPP 1380



 Score = 32.0 bits (71), Expect = 0.83
 Identities = 20/67 (29%), Positives = 31/67 (46%), Gaps = 10/67 (14%)

Query: 241  LQCEASAVPSAEFQWYKDDKRL-----IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
            L C+A   PS   +W KD         I+G++ +   N  F+ +     V   D G Y+C
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI-FSNGSFIIR----TVKAEDSGYYSC 1359

Query: 296  VASNKLG 302
            +A+N  G
Sbjct: 1360 IANNNWG 1366


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 75/278 (26%), Positives = 117/278 (42%), Gaps = 30/278 (10%)

Query: 40  KAMDNVTVRQGESATLRCTIDNRVTRV--AWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
           K    V+VR+G+   L C        +  AW      LY   D    + R V    +Q  
Sbjct: 127 KTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQED----NRRFV----SQET 178

Query: 98  YSIEIQNVDVYDEGPYTC---------SVQTDNHPKTSRVHLIV-QVSPKI-VEISSDIS 146
            ++ I  V+  D G YTC         SVQ    P   R   ++ +  PKI V     I 
Sbjct: 179 GNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQ 238

Query: 147 INEGNNISLTCIATGRPEPTVTWRHIS----PKAVGFVSEDEYLEIQGITREQSGDYECS 202
             + +++ L C A G P P ++WR +     P  V +      LEI    +E  G YEC 
Sbjct: 239 AAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECI 298

Query: 203 ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
           ASN     + +   +    P +  + + T + +      +C+AS  P+  + W K+ +RL
Sbjct: 299 ASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERL 358

Query: 263 IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
              ++ +++EN   +  +   NVS  D G Y C A NK
Sbjct: 359 -NPEERIQIENGTLI--ITMLNVS--DSGVYQCAAENK 391



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 62/268 (23%), Positives = 112/268 (41%), Gaps = 24/268 (8%)

Query: 43  DNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
           + +   +  S  L C  + N V  ++W         G  K+           +++Q  +E
Sbjct: 235 ETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKY-----------SKSQAILE 283

Query: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATG 161
           I N    DEG Y C          ++  LI    P+  +   +  ++  +N+   C A+G
Sbjct: 284 IPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASG 343

Query: 162 RPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVK 216
           +P P  TW      ++P+      E+  L I  +    SG Y+C+A N          ++
Sbjct: 344 KPNPWYTWLKNGERLNPEE-RIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELR 402

Query: 217 VTVNYPPYISE--AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR 274
           V  + P +      K + V VG    + C+ +A P A   W +  + L + K+   +E+ 
Sbjct: 403 VLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLED- 461

Query: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLG 302
                L  +N++  D G+YTC+A+N+ G
Sbjct: 462 ---GSLKIYNITRSDAGSYTCIATNQFG 486



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 48/179 (26%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 136 PKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI---- 191
           P  V    D+S +E   + L C A G P P   W+  +   + F     Y    G     
Sbjct: 32  PHDVIFPLDLSKSE---VILNCAANGYPSPHYRWKQ-NGTDIDFTMSYHYRLDGGSLAIN 87

Query: 192 ---TREQSGDYECSASNDVAAPVVRRVKVTVNY-PPYISEAKGT-GVPVGQKGTLQC-EA 245
              T +  G Y+C A+N +   + R+ K+   Y   + ++ + T  V  GQ   L C   
Sbjct: 88  SPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPP 147

Query: 246 SAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNK 300
                  + W  +D  L      V+ +NR F+S+    L    V   D GNYTC  +NK
Sbjct: 148 PHFGDLSYAWTFNDNPLY-----VQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNK 201



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 49/192 (25%), Positives = 75/192 (39%), Gaps = 41/192 (21%)

Query: 143 SDISINEGNNISLTCIATGRP----EPTVTWR------HISPKAVGFVSEDE-YLEIQGI 191
           S +S+ EG  + L C   G P    + +  W       ++      FVS++   L I  +
Sbjct: 130 STVSVREGQGVVLLC---GPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKV 186

Query: 192 TREQSGDYECSASNDVA--------APVVRRV---------KVTVNYPPYISEAKGTGVP 234
                G+Y C  +N  A         P+V+R          K+ V +P  I  AK + V 
Sbjct: 187 EPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVK 246

Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
                 L+C A   P  +  W + D   + GK  VK      + ++   N  + D G Y 
Sbjct: 247 ------LECFALGNPVPDISWRRLDGSPLPGK--VKYSKSQAILEIP--NFQQEDEGFYE 296

Query: 295 CVASNKLGHTNA 306
           C+ASN  G   A
Sbjct: 297 CIASNLRGRNLA 308



 Score = 28.5 bits (62), Expect = 9.2
 Identities = 19/71 (26%), Positives = 29/71 (40%)

Query: 99  SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
           S++I N+   D G YTC          +   LIV+    I    S + +  G +I L C 
Sbjct: 463 SLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQ 522

Query: 159 ATGRPEPTVTW 169
            +  P   V +
Sbjct: 523 VSHDPSIEVVF 533


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,387,520
Number of Sequences: 37866
Number of extensions: 575708
Number of successful extensions: 5423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 260
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 1490
Number of HSP's gapped (non-prelim): 2119
length of query: 344
length of database: 18,247,518
effective HSP length: 103
effective length of query: 241
effective length of database: 14,347,320
effective search space: 3457704120
effective search space used: 3457704120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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