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Search of human proteins with 7705413
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705413 neurotrimin isoform 1 [Homo sapiens]
(344 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705413 neurotrimin isoform 1 [Homo sapiens] 701 0.0
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 692 0.0
gi|115298665 neurotrimin isoform 2 [Homo sapiens] 645 0.0
gi|221316762 neurotrimin isoform 4 [Homo sapiens] 637 0.0
gi|4505505 opioid binding protein/cell adhesion molecule-like is... 547 e-156
gi|59939900 opioid binding protein/cell adhesion molecule-like i... 493 e-140
gi|45594240 limbic system-associated membrane protein [Homo sapi... 374 e-104
gi|66346706 neuronal growth regulator 1 [Homo sapiens] 322 4e-88
gi|157819143 IgLON family member 5 [Homo sapiens] 295 5e-80
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 105 5e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 105 5e-23
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 105 5e-23
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 103 2e-22
gi|118572606 hemicentin 1 [Homo sapiens] 103 2e-22
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 102 4e-22
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 102 4e-22
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 99 6e-21
gi|110349719 titin isoform N2-A [Homo sapiens] 97 2e-20
gi|109150416 peroxidasin [Homo sapiens] 97 2e-20
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 91 1e-18
gi|4827022 contactin 2 precursor [Homo sapiens] 90 3e-18
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens] 89 4e-18
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 89 6e-18
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 89 6e-18
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 87 2e-17
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 86 6e-17
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 86 6e-17
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 85 1e-16
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 84 2e-16
gi|7657361 contactin 6 [Homo sapiens] 84 2e-16
>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
Length = 344
Score = 701 bits (1809), Expect = 0.0
Identities = 344/344 (100%), Positives = 344/344 (100%)
Query: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
Query: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
Query: 301 LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Sbjct: 301 LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 692 bits (1787), Expect = 0.0
Identities = 344/355 (96%), Positives = 344/355 (96%), Gaps = 11/355 (3%)
Query: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
Query: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
Query: 301 LGHTNASIMLF-----------GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
LGHTNASIMLF GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF
Sbjct: 301 LGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 355
>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
Length = 344
Score = 645 bits (1663), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 28 GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR 87
GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR
Sbjct: 28 GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPR 87
Query: 88 VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI 147
VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI
Sbjct: 88 VVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI 147
Query: 148 NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV
Sbjct: 148 NEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK
Sbjct: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA 327
GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA
Sbjct: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRA 327
Query: 328 GCVWLLPLLVLHLLLKF 344
GCVWLLPLLVLHLLLKF
Sbjct: 328 GCVWLLPLLVLHLLLKF 344
>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
Length = 316
Score = 637 bits (1644), Expect = 0.0
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
Query: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
Sbjct: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
Sbjct: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
Query: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
Sbjct: 181 SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT 240
Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
Sbjct: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
Query: 301 LGHTNASIMLFG 312
LGHTNASIMLFG
Sbjct: 301 LGHTNASIMLFG 312
>gi|4505505 opioid binding protein/cell adhesion molecule-like
isoform a preproprotein [Homo sapiens]
Length = 345
Score = 547 bits (1410), Expect = e-156
Identities = 264/345 (76%), Positives = 298/345 (86%), Gaps = 1/345 (0%)
Query: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
Sbjct: 1 MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID 60
Query: 61 NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD 120
+RVTRVAWLNRSTILYAGNDKW +DPRV++L NT TQYSI IQNVDVYDEGPYTCSVQTD
Sbjct: 61 DRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTD 120
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-AVGF 179
NHPKTSRVHLIVQV P+I+ ISSDI++NEG++++L C+A GRPEPTVTWRH+S K GF
Sbjct: 121 NHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGF 180
Query: 180 VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKG 239
VSEDEYLEI I R+QSG+YECSA NDVAAP VR+VK+TVNYPPYIS+AK TGV VGQKG
Sbjct: 181 VSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKG 240
Query: 240 TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASN 299
L CEASAVP AEFQW+K++ RL G G+++EN+ +S L FFNVSE DYGNYTCVA+N
Sbjct: 241 ILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATN 300
Query: 300 KLGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
KLG+TNASI L+GPGAV + N SR C+WL L+ H +KF
Sbjct: 301 KLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF 345
>gi|59939900 opioid binding protein/cell adhesion molecule-like
isoform b preproprotein [Homo sapiens]
Length = 338
Score = 493 bits (1270), Expect = e-140
Identities = 241/331 (72%), Positives = 275/331 (83%), Gaps = 1/331 (0%)
Query: 15 VVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTI 74
VV S L GVPVRSGDATFPKAMDNVTVRQGESATLRCTID+RVTRVAWLNRSTI
Sbjct: 8 VVFSATTALLFIPGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTI 67
Query: 75 LYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 134
LYAGNDKW +DPRV++L NT TQYSI IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV
Sbjct: 68 LYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 127
Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-AVGFVSEDEYLEIQGITR 193
P+I+ ISSDI++NEG++++L C+A GRPEPTVTWRH+S K GFVSEDEYLEI I R
Sbjct: 128 PPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKR 187
Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEF 253
+QSG+YECSA NDVAAP VR+VK+TVNYPPYIS+AK TGV VGQKG L CEASAVP AEF
Sbjct: 188 DQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEF 247
Query: 254 QWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGP 313
QW+K++ RL G G+++EN+ +S L FFNVSE DYGNYTCVA+NKLG+TNASI L+GP
Sbjct: 248 QWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGP 307
Query: 314 GAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 344
GAV + N SR C+WL L+ H +KF
Sbjct: 308 GAVIDGVNSASRALACLWLSGTLLAHFFIKF 338
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 374 bits (959), Expect = e-104
Identities = 186/332 (56%), Positives = 248/332 (74%), Gaps = 4/332 (1%)
Query: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
K L +V LRLL L+PTG+PVRS D F + DN+TVRQG++A LRC ++++ ++VAWLNR
Sbjct: 10 KQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNSKVAWLNR 67
Query: 72 STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
S I++AG+DKW LDPRV L +YS+ IQ VDVYDEG YTCSVQT + PKTS+V+LI
Sbjct: 68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLI 127
Query: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
VQV PKI ISSD+++NEG+N++L C+A GRPEP +TWRH++P F E+EYLEI GI
Sbjct: 128 VQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPTGREFEGEEEYLEILGI 187
Query: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSA 251
TREQSG YEC A+N+V++ V++VKVTVNYPP I+E+K G++ +L+CEASAVP+
Sbjct: 188 TREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTGRQASLKCEASAVPAP 247
Query: 252 EFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
+F+WY+DD R I G+++++ S L NV+E YGNYTCVA+NKLG TNAS++LF
Sbjct: 248 DFEWYRDDTR-INSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLF 306
Query: 312 GPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLK 343
PG+V + NG+ A +WLL +L LL K
Sbjct: 307 RPGSVRGI-NGSISLAVPLWLLAASLLCLLSK 337
>gi|66346706 neuronal growth regulator 1 [Homo sapiens]
Length = 354
Score = 322 bits (824), Expect = 4e-88
Identities = 158/323 (48%), Positives = 223/323 (69%), Gaps = 3/323 (0%)
Query: 14 LVVVSLRLLFLVPTGVPVRSGDATFP-KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRS 72
L V L L L+P+ +P FP A+DN+ VR+G++A LRC +++ ++ AWLNRS
Sbjct: 17 LAAVLLSLCCLLPSCLPAGQS-VDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRS 75
Query: 73 TILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIV 132
+I++AG DKW +DPRV + + + YS++IQNVDV D+GPYTCSVQT + P+T +VHL V
Sbjct: 76 SIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTV 135
Query: 133 QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGIT 192
QV PKI +IS+D+++NEG N++LTC+ATG+PEP+++WRHISP A F +YL+I GIT
Sbjct: 136 QVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPF-ENGQYLDIYGIT 194
Query: 193 REQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE 252
R+Q+G+YECSA NDV+ P VR+VKV VN+ P I E K V G+ G ++CE + VP
Sbjct: 195 RDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPA 254
Query: 253 FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFG 312
F+WYK +K+L G++G+ ++N S L NV++ +GNYTCVA+NKLG TNAS+ L
Sbjct: 255 FEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP 314
Query: 313 PGAVSEVSNGTSRRAGCVWLLPL 335
P G++ W L L
Sbjct: 315 PSTAQYGITGSADVLFSCWYLVL 337
>gi|157819143 IgLON family member 5 [Homo sapiens]
Length = 336
Score = 295 bits (754), Expect = 5e-80
Identities = 163/327 (49%), Positives = 211/327 (64%), Gaps = 10/327 (3%)
Query: 12 KCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNR 71
+ L +L L ++ G+ +S + P DN TV +G++ATL C ID VTRVAWLNR
Sbjct: 11 RLLAAAALAGLAVISRGLLSQSLEFNSPA--DNYTVCEGDNATLSCFIDEHVTRVAWLNR 68
Query: 72 STILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLI 131
S ILYAGND+W DPRV LL NT ++SI I V + DEG YTCS QT + P T++V+LI
Sbjct: 69 SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLI 128
Query: 132 VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI 191
V V +IV ISS +++NEG N++L C+A GRPEPTVTWR + GF SE E LEI I
Sbjct: 129 VHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRD---GFTSEGEILEISDI 185
Query: 192 TREQSGDYECSASNDV-AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPS 250
R Q+G+YEC N V +AP RRV VTVNYPP I++ +G+ L+CEA AVP
Sbjct: 186 QRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPP 245
Query: 251 AEFQWYKDDKRLIEG-KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIM 309
A+FQWYKDD+ L G +G+KV+ S L+F NVS YGNYTC A+N+LG ++AS+
Sbjct: 246 ADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGASSASMR 305
Query: 310 LFGPGAVSEVSNGTSRRAGCVWLLPLL 336
L PG+ + N R G + LL L
Sbjct: 306 LLRPGS---LENSAPRPPGLLALLSAL 329
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 105 bits (263), Expect = 5e-23
Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
NVTV GE+A L C + + W+ +L A RV L++ S+EI
Sbjct: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 457
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ D G Y C N + V L+V+ +P++ +S ++G + ++C A+G
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 517
Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P ++W + + + V L IQG+ E +G+Y C A+N+V + VT
Sbjct: 518 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 574
Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
+ Y PP +S V VG++ L CEAS VP WY+ +I +G
Sbjct: 575 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 629
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
KL E D G YTC A N+LG +A I L
Sbjct: 630 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
Score = 82.8 bits (203), Expect = 4e-16
Identities = 78/282 (27%), Positives = 112/282 (39%), Gaps = 34/282 (12%)
Query: 45 VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
V V GE A L C RV W Y G + L P + + I
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIW-------YRGGLEMILAPE------GSSSGKLRIP 636
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
D G YTC + ++ + L V +P++ E+ D+++ G + L C ATGRP
Sbjct: 637 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 696
Query: 164 EPTVTWRHISPKAVGF-----------VSEDEYLEIQGITREQSGDYECSASNDVA-APV 211
PTVTWR + +G + L + + E Y C A N
Sbjct: 697 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQA 756
Query: 212 VRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK-G 268
R+ VT + PP I S A V GQ +L C A P E W KD + L G +
Sbjct: 757 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 816
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
++ + L + + EH G Y+CVA+N G + + L
Sbjct: 817 IRADGSLHLDRAL----QEH-AGRYSCVATNTAGSQHRDVEL 853
Score = 77.8 bits (190), Expect = 1e-14
Identities = 63/222 (28%), Positives = 103/222 (46%), Gaps = 21/222 (9%)
Query: 111 GPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW- 169
G Y+C + V L+VQV P+I ++ NEG SL C+A+G P PT+TW
Sbjct: 834 GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 893
Query: 170 ---RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP-- 223
++ + + VS++ L I + + +G Y C+A+N V + ++++VN P
Sbjct: 894 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQEMRLSVNTKPRI 952
Query: 224 YISEAKGTGVPV------GQKGTLQCEASAVPSAEFQWYKDDKRL--IEGKKGVKVENRP 275
+++ ++ VP+ G++ TL CEA P W KD + + I + G+
Sbjct: 953 HMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS--- 1009
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
L V D G+Y C ASN G + +L G S
Sbjct: 1010 --GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
Score = 74.3 bits (181), Expect = 1e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S EI +EG Y C+ + ++ ++V P + + +++++ G L+C
Sbjct: 363 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 422
Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
G +TW + P + G V++ D LEI GI G Y+C ASN A V R
Sbjct: 423 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 480
Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
V + V P +S G + + C AS P+ W ++ + L E + + V
Sbjct: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 539
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
+ + LI V+ D GNY+C A+N++G ++ L+ P +VS V+
Sbjct: 540 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 587
Score = 45.8 bits (107), Expect = 6e-05
Identities = 43/191 (22%), Positives = 69/191 (36%), Gaps = 26/191 (13%)
Query: 39 PKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
P A ++T +G A+L C + W + L + + N +
Sbjct: 863 PTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY----------NVSKE 911
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-------VEISSDISINEG 150
++ I D G Y C+ + + L V P+I + ++ G
Sbjct: 912 GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAG 971
Query: 151 NNISLTCIATGRPEPTVTW----RHISP--KAVGFVSEDEYLEIQGITREQSGDYECSAS 204
++L C A G P P VTW R + P G + L + + SG YEC+AS
Sbjct: 972 EEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTAS 1030
Query: 205 NDVAAPVVRRV 215
N + R V
Sbjct: 1031 NPAGSASHRYV 1041
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 105 bits (263), Expect = 5e-23
Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
NVTV GE+A L C + + W+ +L A RV L++ S+EI
Sbjct: 525 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 574
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ D G Y C N + V L+V+ +P++ +S ++G + ++C A+G
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 634
Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P ++W + + + V L IQG+ E +G+Y C A+N+V + VT
Sbjct: 635 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 691
Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
+ Y PP +S V VG++ L CEAS VP WY+ +I +G
Sbjct: 692 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 746
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
KL E D G YTC A N+LG +A I L
Sbjct: 747 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780
Score = 85.5 bits (210), Expect = 6e-17
Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+ I + D G Y C + + L+VQV P I D+S EG++ L C A
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061
Query: 160 TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
G PEP +TW G + L ++ + + +G Y C+A N V RR
Sbjct: 4062 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 4120
Query: 215 VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V +T+ P + G + +G + L+C A P+ W +D+ + EG V
Sbjct: 4121 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 4175
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
+ S L VS D G Y C A N++G T A
Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 4208
Score = 83.2 bits (204), Expect = 3e-16
Identities = 82/266 (30%), Positives = 107/266 (40%), Gaps = 40/266 (15%)
Query: 89 VLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK--IVEISSDIS 146
V+L Q S+ + D G Y C V L V P E S +
Sbjct: 1158 VVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLE 1217
Query: 147 INEGNNISLTCIATGRPEPTVTWR--------HISPKAVGFVSEDEYLEIQGITREQSGD 198
G N SL C A G P+P VTWR H P V E+ L + ++ SGD
Sbjct: 1218 RVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVA--VLEEGSLFLASVSPADSGD 1275
Query: 199 YECSASNDVAAPVVRRVKVTVNYPPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQ 254
YEC A+N+V + RR K+ V PP I E A +G+ GQ TL+C+A+ P E
Sbjct: 1276 YECQATNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIV 1333
Query: 255 WYKDDKRLIEGKKG----------VKVENRPFLSK---LIFFNVSEHDYGNYTCVASNKL 301
W K D +L+ G +V L + L F + E D G Y+C A N+
Sbjct: 1334 WLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA 1392
Query: 302 GHTNASIML--------FGPGAVSEV 319
G L G GA EV
Sbjct: 1393 GTAQRDFHLLVLTPPSVLGAGAAQEV 1418
Score = 82.8 bits (203), Expect = 4e-16
Identities = 78/282 (27%), Positives = 112/282 (39%), Gaps = 34/282 (12%)
Query: 45 VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
V V GE A L C RV W Y G + L P + + I
Sbjct: 707 VLVAVGEEAVLVCEASGVPPPRVIW-------YRGGLEMILAPE------GSSSGKLRIP 753
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
D G YTC + ++ + L V +P++ E+ D+++ G + L C ATGRP
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 813
Query: 164 EPTVTWRHISPKAVGF-----------VSEDEYLEIQGITREQSGDYECSASNDVA-APV 211
PTVTWR + +G + L + + E Y C A N
Sbjct: 814 PPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQA 873
Query: 212 VRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK-G 268
R+ VT + PP I S A V GQ +L C A P E W KD + L G +
Sbjct: 874 EARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 933
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
++ + L + + EH G Y+CVA+N G + + L
Sbjct: 934 IRADGSLHLDRAL----QEH-AGRYSCVATNTAGSQHRDVEL 970
Score = 82.4 bits (202), Expect = 5e-16
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 11/226 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+ + V V D G Y C+ + R L VQV P++ + + G + L C+
Sbjct: 1083 SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCV 1142
Query: 159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
A G PEP ++W G + + I +G Y C ASN A V++
Sbjct: 1143 AEGNPEPQLSWSKDGVVLQGRGPQGS-VHFAAIRTSDAGRYRCEASNS-AGVDAWEVELR 1200
Query: 219 VNYPPYISEAKGTGV---PVGQKGTLQCEASAVPSAEFQWYK-DDKRLIEGKKGVKVENR 274
V PP+ + +G+ G+ +L C A P + W K + G+ GV V
Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE 1260
Query: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTN--ASIMLFGPGAVSE 318
L +VS D G+Y C A+N++G T+ A ++++ P ++ E
Sbjct: 1261 ---GSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRE 1303
Score = 82.0 bits (201), Expect = 7e-16
Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
D V VR G+ A L C D A + Y L R L Q +EI
Sbjct: 3040 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 3090
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
Q V D+G Y+C V L VQV P ++ +S G+ + LTC +G
Sbjct: 3091 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 3150
Query: 162 RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
P PTVTW + AV G VS L++ + Q+G Y C A N A +
Sbjct: 3151 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 3209
Query: 217 VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V V P I A+ V GQ+ L CEA P + W KD L + G +
Sbjct: 3210 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 3268
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L+ + D G YTCVA N G
Sbjct: 3269 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 3297
Score = 80.9 bits (198), Expect = 2e-15
Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)
Query: 21 LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
LL L P PV GD + ++ VTV + +L+C + N V ++WL
Sbjct: 2836 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 2884
Query: 80 DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
+ PR+ +L + Q +++ +V D Y C + L VQV P+I
Sbjct: 2885 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 2940
Query: 140 EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
+ + ++ +++SL C P P VTW S + V + L++
Sbjct: 2941 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 3000
Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
SG Y C A N A + V+++V PP +A V VG K L CE A+
Sbjct: 3001 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 3059
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
P WYKD + L+ ++ + +L D G Y+C SN G
Sbjct: 3060 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 3110
Score = 80.5 bits (197), Expect = 2e-15
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
++I+ VD+ DEG YTC+ V L V V P I + ++ E +++L C+A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 160 TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
+G P P V+W + +S VS D L I+ +G Y C ASN VA R
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 1968
Query: 215 VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
+ VN PP I+ P V L C A+ PS W KD + G G++V
Sbjct: 1969 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 2028
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
P L + D G Y+CVA + +G ++L
Sbjct: 2029 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 2065
Score = 79.0 bits (193), Expect = 6e-15
Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)
Query: 45 VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ V G++A L C + ++ W L G D + P VLL Q S
Sbjct: 2455 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 2509
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
G Y+C KT L V ++P I+ E S+D +++ N ISL C
Sbjct: 2510 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 2564
Query: 159 ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
A P P +TW + + + + L+I +E +G Y C +N++ V+
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 2623
Query: 214 RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
V V PP IS+ K V TL+CE+ AVP +WYKD + +
Sbjct: 2624 NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 2683
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ ++V L ++ VS D G Y CVA+N G
Sbjct: 2684 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 2717
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
++EI G YTCS + V L VQ SP + + S + + L C
Sbjct: 3911 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 3970
Query: 159 ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
A+G P PT+TW+ +++ V L I + E +G+Y C A N A + +
Sbjct: 3971 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 4029
Query: 215 VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
++ V PP I G L C+A P W KD + + G +G K
Sbjct: 4030 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 4087
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+P +L+ N+ D G YTC A N +G + L
Sbjct: 4088 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 4123
Score = 76.3 bits (186), Expect = 4e-14
Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)
Query: 48 RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
R GE T+ C + + V+WL L L R +L + T + I V
Sbjct: 3326 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 3375
Query: 107 VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
+ D G +TC + L VQV P + VE +D+ + G+ + L C A G P
Sbjct: 3376 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435
Query: 165 PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
P V+W + P + + L+++ + SG Y C A ++ A R ++TV PP
Sbjct: 3436 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 3494
Query: 224 YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
+I ++ + G L C+A P W+KD + L ++EN +++
Sbjct: 3495 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 3548
Query: 281 IFFNVSEHDYGNYTCVASNKLG 302
+ D G YTC+A + G
Sbjct: 3549 L----RVRDAGLYTCLAESPAG 3566
Score = 75.5 bits (184), Expect = 7e-14
Identities = 72/279 (25%), Positives = 110/279 (39%), Gaps = 23/279 (8%)
Query: 44 NVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS---- 99
+VTV G SA L C R T+ + D L R+ ++++
Sbjct: 794 DVTVELGRSALLACRATGRPP-------PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV 846
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIV--QVSPKIVEISSDISINEGNNISLTC 157
+ ++V D+ PY C + + LIV P+I + + + EG +SL C
Sbjct: 847 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 906
Query: 158 IA-TGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
I GRP P W R + P + + D L + +E +G Y C A+N A
Sbjct: 907 IVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN-TAGSQH 965
Query: 213 RRVKVTVNYPPYISEAKGTGVP-VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
R V++ V PP I + G +L C AS VP+ W K+ L V
Sbjct: 966 RDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV 1025
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L+ S D G Y C A+N +G ++ + L
Sbjct: 1026 SKE---GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRL 1061
Score = 74.3 bits (181), Expect = 1e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S EI +EG Y C+ + ++ ++V P + + +++++ G L+C
Sbjct: 480 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 539
Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
G +TW + P + G V++ D LEI GI G Y+C ASN A V R
Sbjct: 540 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 597
Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
V + V P +S G + + C AS P+ W ++ + L E + + V
Sbjct: 598 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 656
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
+ + LI V+ D GNY+C A+N++G ++ L+ P +VS V+
Sbjct: 657 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 704
Score = 73.2 bits (178), Expect = 3e-13
Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)
Query: 42 MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+ N+T TL C + + W + G D + L +L TQTQ
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 2416
Query: 101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
D G Y+C + + V V P I ++ I + +G L C
Sbjct: 2417 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 2468
Query: 159 ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
TG P+P +TW HISP V L++ +G Y C A+N
Sbjct: 2469 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 2521
Query: 207 VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
V + +++V P I S + V V +L CEA A PS W KD
Sbjct: 2522 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580
Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
E + +++ P L N + D G YTCV +N+LG N + + P ++S+
Sbjct: 2581 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 2637
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)
Query: 82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
W D +L + + S++++ V D G Y+C ++ L V P I +
Sbjct: 3440 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499
Query: 142 S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
+++S+ G + L C A G P+P +TW H +A+ + E+ + + +G Y
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 3557
Query: 200 ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
C A + A + + +V V PP I +G G+ GQ L+C A P+ + W
Sbjct: 3558 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 3615
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
++D L E E FL +S D G+Y+C A N G T+ + +
Sbjct: 3616 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 3672
Query: 311 ----FGPGAVSEVSNGTS 324
GP AV+ N T+
Sbjct: 3673 PTIRSGPPAVNVSVNQTA 3690
Score = 72.0 bits (175), Expect = 7e-13
Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D + C V + + V V P I + +D ++ + LTC +TG P PTV+
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889
Query: 169 W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W + + G+ VS LEI +G Y CSA N A + V +TV P
Sbjct: 3890 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 3948
Query: 224 YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
+ V ++ L CEAS +P W K+ + GV + P +L
Sbjct: 3949 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 4004
Query: 283 FNVSEHDYGNYTCVASNKLG 302
+ S D GNY C+A N G
Sbjct: 4005 AHASPEDAGNYLCIAKNSAG 4024
Score = 71.6 bits (174), Expect = 9e-13
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
EG YTC + + L V V P+I E + +S+ + +L C ATG+P PT
Sbjct: 2230 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 2289
Query: 167 VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
VTW + VG ++ + L ++ +G Y C A N +A R+ +++V
Sbjct: 2290 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 2347
Query: 221 YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
PP + + TL CEA +P +W++ ++ + G+ +
Sbjct: 2348 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 2407
Query: 277 LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
L E D G Y+C+ASN+ G N S+ + P ++
Sbjct: 2408 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 2446
Score = 70.1 bits (170), Expect = 3e-12
Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 79 NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
N W D +L ++T+ Y+ +++ D G YTC L V
Sbjct: 1533 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591
Query: 134 VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
V P I + G ++L C+A G P PT++W H ++
Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 1651
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
L ++ SG Y C AS+ A V + V V PP + A+G G VGQ L
Sbjct: 1652 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 1710
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
C+AS P QW ++ R E GV+V ++ + L +V G + C A+N+ G
Sbjct: 1711 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 1767
Query: 303 HTNASI 308
A +
Sbjct: 1768 TAGAEV 1773
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 16/223 (7%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
+++ DV+D G YTC +L V V+P + S +++ EG+ SL+C
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 2185
Query: 159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
G P P ++WR G + +++ G Q G Y C SN V
Sbjct: 2186 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 2244
Query: 212 VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ +++ V+ PP I+ + T V V Q G TL+C A+ P W +D + + +
Sbjct: 2245 SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 2303
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G++++N+ L G Y+CVA N G L
Sbjct: 2304 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 2344
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
++I V + G Y+C + L+V P I+ E+ ++++N + +SL
Sbjct: 2806 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 2865
Query: 156 TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
C A G P PT++W SP V ED + L++ + Y C A N A
Sbjct: 2866 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 2924
Query: 211 VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + V PP I+ + + + +L C+ A P+ E WYKD + L G
Sbjct: 2925 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 2981
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+V P L D G YTC A N G + L
Sbjct: 2982 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 3023
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/251 (25%), Positives = 88/251 (35%), Gaps = 69/251 (27%)
Query: 111 GPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR 170
G Y+C + V L+VQV P+I ++ NEG SL C+A+G P PT+TW
Sbjct: 951 GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 1010
Query: 171 H-----------------------------------ISPKAVGFVSEDEYLEIQGITREQ 195
+ VGF S++ L + + +
Sbjct: 1011 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSK 1070
Query: 196 -----------------------SGDYECSASNDVAAPVVRRVKVTVNYPPYISEA-KGT 231
SG YEC+ASN A R + V PP + +
Sbjct: 1071 YVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNP-AGSASHRYVLGVQVPPQVQPGPRVL 1129
Query: 232 GVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYG 291
V VG+ L C A P + W KD GV ++ R + F + D G
Sbjct: 1130 KVLVGEALDLNCVAEGNPEPQLSWSKD---------GVVLQGRGPQGSVHFAAIRTSDAG 1180
Query: 292 NYTCVASNKLG 302
Y C ASN G
Sbjct: 1181 RYRCEASNSAG 1191
Score = 67.4 bits (163), Expect = 2e-11
Identities = 60/230 (26%), Positives = 93/230 (40%), Gaps = 30/230 (13%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS--SDISINEGNNISLT 156
S+ + +V D G Y C + + R L+V V P I E +++S G +++L
Sbjct: 1262 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 1321
Query: 157 CIATGRPEPTVTWRHISPKAVG---------------------FVSEDEYLEIQGITREQ 195
C A G P P + W + VG + E + L I
Sbjct: 1322 CDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGD 1380
Query: 196 SGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT---LQCEASAVPSAE 252
SG Y C A N A R + V PP + A +G G LQC S VP+ +
Sbjct: 1381 SGLYSCRAENQ-AGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ 1439
Query: 253 FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+W KD + ++ G ++V+ + ++ +V D G Y CVA + G
Sbjct: 1440 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAG 1487
Score = 66.2 bits (160), Expect = 4e-11
Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)
Query: 88 VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
+VL + TQ+ +++Q + D G Y+C+ + + + + P I
Sbjct: 3620 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 3679
Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
++++ L C A G P P V+WR + P++ F + + L IQ + + +G
Sbjct: 3680 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 3739
Query: 198 DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
Y C ASN + R + P + L CEAS P W+K
Sbjct: 3740 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 3799
Query: 258 D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
D D RL +G + N L+ D + CV SN++G +
Sbjct: 3800 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 3846
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 37/238 (15%)
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-------SDISINEG 150
+ ++I N D G YTC V + H+ V + P I + ++
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654
Query: 151 NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
+ ++L C + P PT+ W + ++P + + + E L+IQ SG Y C A+N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 206 DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
VA + V + PP EA+G + L C+
Sbjct: 2715 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+A+P + WY++D+ L G + ++ L + V + G Y+C ASN++G
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 2828
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 11/210 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D G Y+C + V L V + P I+ ++S+ +++L C + P P ++
Sbjct: 2044 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103
Query: 169 W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W R + P+ +S D+ L++ +G Y C A N A + + V P
Sbjct: 2104 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVWVAP 2162
Query: 224 Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
+ E+ V G +L CE VP + W KD + L +G +++ + +L+
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 2220
Query: 282 FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
+ ++ G YTC SN +G+++ + L
Sbjct: 2221 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 2250
Score = 60.8 bits (146), Expect = 2e-09
Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)
Query: 81 KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
+W D + VL Q + I V DEG Y C + + L V
Sbjct: 1441 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 1500
Query: 136 PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
P I + ++++ E + + L C A G P P +TW S K V + L+
Sbjct: 1501 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 1559
Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
+ +G Y C ASN V A + ++ V PP I A G V G+ L+C
Sbjct: 1560 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 1618
Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
A PS W+ + + E + ++E S L + E G Y+CVAS+ G
Sbjct: 1619 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 1674
Score = 60.5 bits (145), Expect = 2e-09
Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)
Query: 25 VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
VPT +RSG P A+ NV+V Q +A L C D V+W D+
Sbjct: 3672 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 3712
Query: 84 LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
LDPR + S+ IQ V D G Y C L V P I S
Sbjct: 3713 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 3771
Query: 144 DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
++++ L C A+G P+P V W K + + Y L + + S
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 3831
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
+EC SN+V R +VTV+ PP I++ + V + L C ++ +P+ W
Sbjct: 3832 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 3890
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K +L G +G P + I + H G YTC A N G + + L
Sbjct: 3891 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 3942
Score = 59.3 bits (142), Expect = 5e-09
Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 24/272 (8%)
Query: 46 TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
++R G+ LRC T R+ W ND+ P +S +++
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 4186
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
V D G Y C + + +T V + V+ +P + E S + G +I L C+ G
Sbjct: 4187 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 4245
Query: 163 PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P + W + + ++ L I R+ +G Y+C A N++ + V
Sbjct: 4246 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 4305
Query: 219 VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
+ P + E + V G L+C+A+ P+ +W + + L ++ + +
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 4361
Query: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L NV D G Y CVA N LG A L
Sbjct: 4362 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 4393
Score = 53.5 bits (127), Expect = 3e-07
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 5/144 (3%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+ I + D G Y C + + V L++Q +P D+++ G++++L C
Sbjct: 4272 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 4331
Query: 159 ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
ATG P PT+ W D L ++ + +G Y+C A N + + R
Sbjct: 4332 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 4391
Query: 215 VKVTVNYPPYISEAKGTGVPVGQK 238
V V P S TGV G+K
Sbjct: 4392 FLV-VRGEPQGSWGSMTGVINGRK 4414
Score = 35.4 bits (80), Expect = 0.075
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)
Query: 17 VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
V+ +++ LV PV F ++TVR G+ LRC T + WL L
Sbjct: 4296 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 4349
Query: 76 YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
A T S+ ++NV+ D G Y C T+R L+V+
Sbjct: 4350 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 4398
Query: 136 PK 137
P+
Sbjct: 4399 PQ 4400
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 105 bits (263), Expect = 5e-23
Identities = 82/275 (29%), Positives = 124/275 (45%), Gaps = 27/275 (9%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
NVTV GE+A L C + + W+ +L A RV L++ S+EI
Sbjct: 524 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG------RVAQLADL----SLEI 573
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ D G Y C N + V L+V+ +P++ +S ++G + ++C A+G
Sbjct: 574 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 633
Query: 163 PEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P ++W + + + V L IQG+ E +G+Y C A+N+V + VT
Sbjct: 634 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD---QETVT 690
Query: 219 VNY--PPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
+ Y PP +S V VG++ L CEAS VP WY+ +I +G
Sbjct: 691 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS----- 745
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
KL E D G YTC A N+LG +A I L
Sbjct: 746 -SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
Score = 74.3 bits (181), Expect = 1e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 15/231 (6%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S EI +EG Y C+ + ++ ++V P + + +++++ G L+C
Sbjct: 479 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 538
Query: 159 ATGRPEPTVTW---RHISPKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
G +TW + P + G V++ D LEI GI G Y+C ASN A V R
Sbjct: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN--ANGVTR 596
Query: 214 -RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
V + V P +S G + + C AS P+ W ++ + L E + + V
Sbjct: 597 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHV 655
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF--GPGAVSEVS 320
+ + LI V+ D GNY+C A+N++G ++ L+ P +VS V+
Sbjct: 656 DAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 703
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 103 bits (258), Expect = 2e-22
Identities = 84/282 (29%), Positives = 121/282 (42%), Gaps = 24/282 (8%)
Query: 45 VTVRQGESATLRCTIDNRVTR------VAWLNRST----ILYAGNDKWCLDPRVVLLSNT 94
VT R GES LRC + + VT V W + G +DP ++
Sbjct: 33 VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL 92
Query: 95 QTQYSIEIQNVDVYDEGPYTCSV-----QTDNHPKTSRVHLIVQVSPKIVEISSD-ISIN 148
+ S+ ++ V D+G Y C V Q D S VHL + P E I
Sbjct: 93 HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAK 152
Query: 149 EGNNISLTCIATGRPEPTVTWRH---ISPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
EG +I++TC A G P+P VTW + + + D L + ++RE G Y C A +
Sbjct: 153 EGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYS 212
Query: 206 DVAAPVVRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASAVP-SAEFQWYKDDKRLI 263
+ V + V PP+I S + V + Q L C A A P + + WY D+ +
Sbjct: 213 -IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDEN-V 270
Query: 264 EGKKGVKVENRPFLS-KLIFFNVSEHDYGNYTCVASNKLGHT 304
+ +K+ R + LI F V D G YTCV SN LG +
Sbjct: 271 YFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRS 312
Score = 79.3 bits (194), Expect = 5e-15
Identities = 77/272 (28%), Positives = 107/272 (39%), Gaps = 30/272 (11%)
Query: 45 VTVRQGESATLRCT-IDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ ++G S T+ CT N V WL T+L A D S+ +
Sbjct: 149 IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDG------------SLTVT 196
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
+V D G YTC + HL+VQ P IV +I++N + LTC A P
Sbjct: 197 SVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYP 256
Query: 164 -EPTVTWRHISPKAVGFVSE---------DEYLEIQGITREQSGDYECSASNDVAAPVVR 213
T TW + + V F ++ D L I + E SG Y C SN +
Sbjct: 257 GNLTYTW-YWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSA 315
Query: 214 RVKVTVNYPPYISEAKGT-GVPVGQKGTLQCEASAVPSAE-FQWYKDDKRL-IEGKKGVK 270
+TV YP + VPVG G ++C A P A +W KD + L +E G
Sbjct: 316 SAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWT 375
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ + +E G YTCV N LG
Sbjct: 376 LMED---GSIRIEEATEEALGTYTCVPYNTLG 404
Score = 51.6 bits (122), Expect = 1e-06
Identities = 71/286 (24%), Positives = 112/286 (39%), Gaps = 36/286 (12%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVA--WLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+N+TV + A L C + + W + +Y ND L RV +L + ++
Sbjct: 236 ENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQND---LKLRVRILIDG----TL 288
Query: 101 EIQNVDVYDEGPYTC--SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
I V D G YTC S P S +L VQ +++ + I + G + + C
Sbjct: 289 IIFRVKPEDSGKYTCVPSNSLGRSPSAS-AYLTVQYPARVLNMPPVIYVPVGIHGYIRCP 347
Query: 159 ATGRPEPTVT-WRHIS-----PKAVGF-VSEDEYLEIQGITREQSGDYECSASNDV---- 207
P TV W K +G+ + ED + I+ T E G Y C N +
Sbjct: 348 VDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMG 407
Query: 208 -AAPVVRRVKVTVNYPPYISEAKGTGV--PVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
+AP ++ + PPY + G G++ + C A+ P W K
Sbjct: 408 QSAPA----RLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRK------V 457
Query: 265 GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
GK + L F +S+ D+G + CVA+N + AS L
Sbjct: 458 GKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHL 503
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 103 bits (257), Expect = 2e-22
Identities = 84/278 (30%), Positives = 123/278 (44%), Gaps = 35/278 (12%)
Query: 46 TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
TV + A L C D T + W + +L K+ +P L+ ++N
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELI----------LEN 4228
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
V + D G YTC T V L V V P E+ D+S+N+G + L+C ATG P
Sbjct: 4229 VVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPL 4288
Query: 165 PTVTW---RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK-VTVN 220
P +TW +I P V+ L I+ +++E SG Y C+A N V V+ + V V
Sbjct: 4289 PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG--FVKAIGFVYVK 4346
Query: 221 YPPYISEAKGTG--VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
PP + P+G L CE P+ QW +KGV +E +
Sbjct: 4347 EPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQW---------NRKGVDIEISHRIR 4397
Query: 279 KL------IFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+L I+ V+E D G+YTCVA+N+ G S+ L
Sbjct: 4398 QLGNGSLAIYGTVNE-DAGDYTCVATNEAGVVERSMSL 4434
Score = 102 bits (253), Expect = 7e-22
Identities = 76/277 (27%), Positives = 116/277 (41%), Gaps = 25/277 (9%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSN-----TQTQ 97
+NVTV GE A L C I + V N W + R V L+ T
Sbjct: 527 NNVTVTPGERAVLTCLIISAVDY-------------NLTWQRNDRDVRLAEPARIRTLAN 573
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
S+E+++V D G Y C V ++ + V L VQ PK+ + + S G+ +S+ C
Sbjct: 574 LSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMC 633
Query: 158 IATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
ATG P+P + W VG ++ D L I+ + +G Y C ASN
Sbjct: 634 SATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693
Query: 214 RVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
+ P + V +G ++C+ S +P + +W+K D +E + +
Sbjct: 694 STLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGD---LELRPSTFLII 750
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
P L L + D G+YTCVA N+ G I L
Sbjct: 751 DPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITL 787
Score = 90.5 bits (223), Expect = 2e-18
Identities = 79/281 (28%), Positives = 123/281 (43%), Gaps = 34/281 (12%)
Query: 42 MDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+++V V++ +S TL C + N V + W L D ++S + +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQE-------DEAHHIISGGRF---L 2535
Query: 101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-----ISINEGNNISL 155
+I NV V G YTC + K+ L V VSP I + SD +++ + SL
Sbjct: 2536 QITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSL 2595
Query: 156 TCIATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
C A P T+TW S + + + L+I + +G Y C A+N+ A
Sbjct: 2596 VCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNE-AGE 2654
Query: 211 VVRRVKVTVNYPPYISEA---------KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
+++ +V V PP I++ K + V TL+CEA A+PSA WYKD +
Sbjct: 2655 MIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP 2714
Query: 262 LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L + V + ++ +S D G YTCVASN G
Sbjct: 2715 L-KSDDHVNIAANGHTLQIKEAQIS--DTGRYTCVASNIAG 2752
Score = 90.1 bits (222), Expect = 3e-18
Identities = 78/279 (27%), Positives = 117/279 (41%), Gaps = 28/279 (10%)
Query: 45 VTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ V +G+S +L C + V W+ L LD +L +++
Sbjct: 2302 IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHIL----------QLK 2351
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIAT 160
N+ V D G Y C + L V P I+ +IS+ E N++SLTC A+
Sbjct: 2352 NIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEAS 2411
Query: 161 GRPEPTVTWRHIS-----PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRV 215
G P P++TW +V +S L + T E +G Y C N AA R++
Sbjct: 2412 GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRN--AAGEERKI 2469
Query: 216 -KVTVNYPPYI---SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
++V PP+I + + V Q TL CE + P E W+KD + L E + +
Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII 2529
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
FL NV G YTC+AS+ GH + S L
Sbjct: 2530 SGGRFLQ---ITNVQVPHTGRYTCLASSPAGHKSRSFSL 2565
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/219 (31%), Positives = 98/219 (44%), Gaps = 13/219 (5%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
+IEI + G YTC + V L V P I S++ + N I L C
Sbjct: 3951 AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCE 4010
Query: 159 ATGRPEPTVTWRH--ISPKAVG---FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
ATG P P +TW+ I+ G V L+I RE +G Y C A N A +
Sbjct: 4011 ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNP-AGTALG 4069
Query: 214 RVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
++K+ V PP IS K + V + TL CEA +P + W+KD + ++E +
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVE-----SIR 4124
Query: 273 NRPFLS-KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
R S L V D G+YTC+A+N G ++ S L
Sbjct: 4125 QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKL 4163
Score = 85.5 bits (210), Expect = 6e-17
Identities = 81/295 (27%), Positives = 114/295 (38%), Gaps = 22/295 (7%)
Query: 23 FLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRV-AWLNRSTILYAGNDK 81
+LV VP P+ ++TV + TL C D V WL L A
Sbjct: 3612 YLVRVHVPPNIAGTDEPR---DITVLRNRQVTLECKSDAVPPPVITWLRNGERLQA---- 3664
Query: 82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
PRV +LS + ++I N D+ D YTC T L V V P I
Sbjct: 3665 ---TPRVRILSGGRY---LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGG 3718
Query: 142 SSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQS 196
+ I + L CIA G P P +TWR G + E+ +L IQ +
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDT 3778
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQW 255
G Y C A+N A RR+ + V+ PP I+ V V + TL CEA+ +P W
Sbjct: 3779 GRYLCMATN-AAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW 3837
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K+ L+ + L+ + S D Y C +N G ++ L
Sbjct: 3838 RKNG-HLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL 3891
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/234 (26%), Positives = 102/234 (43%), Gaps = 15/234 (6%)
Query: 82 WCLDPRVVLLSNTQ---TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI 138
W D R ++ S Q + S++I V D G YTC ++ L V V P+I
Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171
Query: 139 VEISSDISINEGNNISLTCIATGRPEPTVTWRH---ISPKAVGFVSEDEY--LEIQGITR 193
++NE + L C+A G P P + W+ + +G + + Y L ++ +
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL 4231
Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAE 252
E SG Y C A N+ A V +TV+ P +E G + G++ L C+A+ +P +
Sbjct: 4232 EDSGFYTCVA-NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPK 4290
Query: 253 FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
W ++ + V S+L+ VS+ D G Y C A N +G A
Sbjct: 4291 LTWTFNNNIIPAHFDSVNGH-----SELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Score = 84.3 bits (207), Expect = 1e-16
Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 13/215 (6%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNNIS 154
+++I V D G YTC + L V V P I + S+ +++ EG ++S
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVS 3078
Query: 155 LTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
L C + P P +TW R I+ V +++ + L I+ +G Y C A N VA
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAG 3137
Query: 210 PVVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ + V PP I E + + TL C+A+ +P W K+ KR IE
Sbjct: 3138 RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKR-IENSD 3196
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
++V SKL D GNYTC+ASN G
Sbjct: 3197 SLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Score = 84.0 bits (206), Expect = 2e-16
Identities = 76/288 (26%), Positives = 121/288 (42%), Gaps = 47/288 (16%)
Query: 47 VRQGESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
V +G+ TL CT+ N + W+ S +L +P + + S+ S+ I+
Sbjct: 901 VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ-------NPYITVRSDG----SLHIER 949
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
V + D G YTC ++V V P I +S EG ++L C A+G P+
Sbjct: 950 VQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPK 1009
Query: 165 PTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
P+V W IS + F D L + E+SG+Y C+A+N A R+V++TV
Sbjct: 1010 PSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN-TAGYAKRKVQLTV 1068
Query: 220 NYPPYI-------SEAKGTGVPV--GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
P + S+ K + V G++ TL CE ++P W K+ + +
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLI-------- 1120
Query: 271 VENRPFLSKLIFF--------NVSEHDYGNYTCVASNKLGHTNASIML 310
PF + F D G Y CVA+N G+ ++ L
Sbjct: 1121 ---SPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKL 1165
Score = 83.2 bits (204), Expect = 3e-16
Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 37/292 (12%)
Query: 39 PKAMDN------VTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLL 91
P MDN +TV +G S ++ C D +AWL L LD + +
Sbjct: 3433 PPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLG-------LDAHLTVS 3485
Query: 92 SNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINE 149
++ +++ + D G YTC + + L V P I E +IS+
Sbjct: 3486 THGMV---LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIV 3542
Query: 150 GNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSAS 204
N + LTCIA+G P P +TW V + E L I E +G Y C AS
Sbjct: 3543 NNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLAS 3602
Query: 205 NDVAAPVVRRVKVTVNYPPYIS---EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
+ A + V V+ PP I+ E + V ++ TL+C++ AVP W ++ +R
Sbjct: 3603 SP-AGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGER 3661
Query: 262 LIEGKKGVKVENRPFLSKLIFFNVSEHDYG---NYTCVASNKLGHTNASIML 310
L + V++ LS + ++ D G NYTCVASN G T +L
Sbjct: 3662 L-QATPRVRI-----LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Score = 82.0 bits (201), Expect = 7e-16
Identities = 75/292 (25%), Positives = 115/292 (39%), Gaps = 28/292 (9%)
Query: 23 FLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDK 81
F + VP FP + V+V L C + + W L+ G
Sbjct: 1444 FNIDVLVPPTIIGTNFP---NEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG--- 1497
Query: 82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV-- 139
DP V LL Q + ++N D+G Y C+V + + L + + P I
Sbjct: 1498 ---DPNVELLDRGQV---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 140 EISSDISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITRE 194
+++DIS+ + I L C G P P +TW +S ++ + +YL I
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 195 QSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT----GVPVGQKGTLQCEASAVPS 250
S Y C +N VA + V V PP I T V + TL+C+A+ PS
Sbjct: 1612 DSATYTCHVAN-VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670
Query: 251 AEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
W KD ++ +++E KL + E D G Y CVA++ G
Sbjct: 1671 PILTWLKDGVP-VKANDNIRIEAGG--KKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/228 (27%), Positives = 103/228 (45%), Gaps = 17/228 (7%)
Query: 91 LSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISIN 148
LS ++ + ++I++ V D G YTC ++ + V P I + + +++
Sbjct: 2150 LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVI 2209
Query: 149 EGNNISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEYLEIQGITREQSGDYEC 201
EGN ISL C ++G P P + W+ S V +S L+I + + Y C
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSC 2269
Query: 202 SASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQCEASAVPSAEFQWYK 257
ASN VA + + V P I+ + + G+ +L+CE +P W K
Sbjct: 2270 VASN-VAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK 2328
Query: 258 DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
D LI+ KGV++ + + +L +VS D G Y CVA N G T+
Sbjct: 2329 DGHPLIKA-KGVEILDEGHILQLKNIHVS--DTGRYVCVAVNVAGMTD 2373
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 18/218 (8%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN-----EGNNI 153
++ I D G YTC + + L VQ P + ++ + I
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRI 1284
Query: 154 SLTCIATGRPEPTVTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDV 207
C A G P+PT+ W H + G + + L I +T +G+Y C A N+
Sbjct: 1285 EFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE- 1343
Query: 208 AAPVVRRVKVTVNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
A R+ + V+ PP I + + V + Q L CE PS WYKD+ ++ E
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE 1403
Query: 265 GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
V N L F + D G Y+C A N G
Sbjct: 1404 SSTIQTVNNGKILK---LFRATPEDAGRYSCKAINIAG 1438
Score = 76.6 bits (187), Expect = 3e-14
Identities = 65/223 (29%), Positives = 93/223 (41%), Gaps = 26/223 (11%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
++IQ D G YTC + T ++ L V P ++ +D+S+ G+N++L C
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYV 816
Query: 160 TGRPEPTVTWRHIS-------PKAVGFVSE--DEYLEIQGITREQSGDYECSASNDVA-A 209
G PEPT+ WR + P +V +S+ L I + G Y C A N
Sbjct: 817 QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKI 876
Query: 210 PVVRRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK 267
V VT P I + V GQ+ TL C A P E +W K+ L++
Sbjct: 877 QSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ--- 933
Query: 268 GVKVENRPFLS-----KLIFFNVSEHDYGNYTCVASNKLGHTN 305
P+++ L V D G YTCVASN G N
Sbjct: 934 ------NPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN 970
Score = 76.6 bits (187), Expect = 3e-14
Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 17/235 (7%)
Query: 82 WCLDPRVVLLSNTQTQYS----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK 137
W D R++ S + T + I+I++ + D G Y C L V V+P
Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Query: 138 IVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGF------VSEDEYLEIQGI 191
I ++ +++ N + L C A G P P++TW F +S L +
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA 2073
Query: 192 TREQSGDYECSASNDVAAPVVRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASAVPS 250
+G Y C A N A R + + V PP I E + V + Q L C++ A+P
Sbjct: 2074 QISDTGRYTCVAVN-AAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 251 AEFQWYKDDKRLIEGKKGVKV-ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
W KD L++ K G+ + ENR S L + D G YTC A+N G T
Sbjct: 2133 PTLTWLKDGHPLLK-KPGLSISENR---SVLKIEDAQVQDTGRYTCEATNVAGKT 2183
Score = 76.6 bits (187), Expect = 3e-14
Identities = 72/276 (26%), Positives = 112/276 (40%), Gaps = 23/276 (8%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
++ + +S L C + T R+ W +L AGN R +L N + I
Sbjct: 3721 SLVILLNKSTVLECIAEGVPTPRITWRKDGAVL-AGNHA-----RYSILENG----FLHI 3770
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
Q+ V D G Y C R+ L V V P I +++++ +L C ATG
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGI 3830
Query: 163 PEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQSGDYECSASNDVAAPVVRRV 215
P+P++ WR +++ Y L I + + + YEC+ +N A R V
Sbjct: 3831 PKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNG-AGDDKRTV 3889
Query: 216 KVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR 274
+TV PP I+ E V + C AS VP W K+ RL+ G ++ +
Sbjct: 3890 DLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSS 3949
Query: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+ L + G YTCVA N G + + L
Sbjct: 3950 GAIEILA---TQLNHAGRYTCVARNAAGSAHRHVTL 3982
Score = 75.9 bits (185), Expect = 5e-14
Identities = 64/228 (28%), Positives = 99/228 (43%), Gaps = 19/228 (8%)
Query: 87 RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS--- 143
RV +LS + ++I + D Y+C +L V + P I S
Sbjct: 2244 RVRILSGGR---QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300
Query: 144 DISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGD 198
+I + G +ISL C G P PTVTW I K V + E L+++ I +G
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGR 2360
Query: 199 YECSASNDVAAPVVRRVKVTVNYPPYI--SEAKGTGVPVGQKG--TLQCEASAVPSAEFQ 254
Y C A N VA ++ ++V+ PP I + + V +K +L CEAS +P
Sbjct: 2361 YVCVAVN-VAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT 2419
Query: 255 WYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
W+KD + V++ + + +L+ + D G YTCV N G
Sbjct: 2420 WFKDGWP-VSLSNSVRILSGGRMLRLM--QTTMEDAGQYTCVVRNAAG 2464
Score = 73.9 bits (180), Expect = 2e-13
Identities = 63/220 (28%), Positives = 95/220 (43%), Gaps = 12/220 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTC 157
+EI + D G Y C + K + + V V P I + +S + N + L C
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 158 IATGRPEPTVTWR---HISPKAVGF--VSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
TG P PT+ W + + GF + L I +G Y C A+N A
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAAN-TAGDHK 1815
Query: 213 RRVKVTVNYPPYI-SEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
+ +VTV+ PP I S V V K LQC A+ +P+ W KDD+ + + +K
Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK 1875
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+++ + ++ D G YTCVA+N G T I L
Sbjct: 1876 IQSSGRVLQIA--KTLLEDAGRYTCVATNAAGETQQHIQL 1913
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 37/278 (13%)
Query: 45 VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
++V GE TL C + + + + T L + PR L + S++I
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISP-----FSPRHTFLPSG----SMKITE 1139
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164
D G Y C T V L V V PKI + + G + + C A G P
Sbjct: 1140 TRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199
Query: 165 PTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
P +TW H+S + D L I T +G Y C A+N +A
Sbjct: 1200 PVITWSKGGSTMLVDGEHHVS-------NPDGTLSIDQATPSDAGIYTCVATN-IAGTDE 1251
Query: 213 RRVKVTVNYPPYISEAKG------TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
+ + V PP + + + Q+ C A P +W + + L +
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
G+ + L L+ +V+ +D G Y CVA N+ G T
Sbjct: 1312 PGISILEDGTL--LVIASVTPYDNGEYICVAVNEAGTT 1347
Score = 72.0 bits (175), Expect = 7e-13
Identities = 57/219 (26%), Positives = 92/219 (42%), Gaps = 11/219 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS--INEGNNISLTC 157
++I + D G YTC + L V P + + ++ + N + L C
Sbjct: 1883 LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942
Query: 158 IATGRPEPTVTW----RHIS-PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
A G P P +TW R +S ++ F++ + ++I+ +G Y+C A N A +
Sbjct: 1943 KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATEL 2002
Query: 213 RRVKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
+ V+ P IS + V V L+CEA +P+ W KD + G++V
Sbjct: 2003 -FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQV 2061
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+ + L +S D G YTCVA N G I L
Sbjct: 2062 LSGGRILALTSAQIS--DTGRYTCVAVNAAGEKQRDIDL 2098
Score = 72.0 bits (175), Expect = 7e-13
Identities = 71/281 (25%), Positives = 116/281 (41%), Gaps = 28/281 (9%)
Query: 43 DNVTVRQGESATLRC-TIDNRVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+ VTV +SA + C + + R +W + +L + K+ + R++ + NTQ
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQ----- 2934
Query: 101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIA 159
+ D G Y C + +L V V P ++ S+ +++ N ISLTC
Sbjct: 2935 ------ITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 160 TGRPEPTVTW-RHISPKAVG----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
+G P P ++W ++ P + V L+I G+Y C A N A ++
Sbjct: 2989 SGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQ-AGESKKK 3047
Query: 215 VKVTVNYPPYISEAKGTGVPV-----GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
+TV PP I + + V G +L+CE++AVP WYK+ + + E
Sbjct: 3048 FSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITE---ST 3104
Query: 270 KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
VE L D G Y C A N G + + L
Sbjct: 3105 HVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Score = 70.1 bits (170), Expect = 3e-12
Identities = 61/217 (28%), Positives = 87/217 (40%), Gaps = 20/217 (9%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE----ISSD----ISINEGNNISLTCIAT 160
+ G Y C+ +V L V V P++ +S D IS+ G ++L C
Sbjct: 1045 ESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104
Query: 161 GRPEPTVTWRHISPKAVGFVSEDEYL-----EIQGITREQSGDYECSASNDVAAPVVRRV 215
P P +TW + F +L +I SG Y C A+N +A V + V
Sbjct: 1105 SLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN-IAGNVTQAV 1163
Query: 216 KVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR-LIEGKKGVKVEN 273
K+ V+ PP I K V VGQ+ + C A P W K L++G+ V +
Sbjct: 1164 KLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD 1223
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L + D G YTCVA+N G I L
Sbjct: 1224 ----GTLSIDQATPSDAGIYTCVATNIAGTDETEITL 1256
Score = 68.6 bits (166), Expect = 8e-12
Identities = 62/220 (28%), Positives = 90/220 (40%), Gaps = 19/220 (8%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEPT 166
D G YTC L +QV P + EI SD+S+ G N+ L C A G P P
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL 3277
Query: 167 VTW-RHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
+ W + P A G + L I G +G Y C A+N A R + V
Sbjct: 3278 IQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNP-AGEEDRIFNLNV 3336
Query: 220 NYPPYI----SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
P I EA+ V ++C A+ P + W K+ L +++
Sbjct: 3337 YVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPL-PLSSHIRLLAAG 3395
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNA--SIMLFGP 313
+ +++ VS D YTCVASN+ G N ++ +F P
Sbjct: 3396 QVIRIVRAQVS--DVAVYTCVASNRAGVDNKHYNLQVFAP 3433
Score = 65.9 bits (159), Expect = 5e-11
Identities = 58/211 (27%), Positives = 88/211 (41%), Gaps = 10/211 (4%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+ + + + D G YTC K + L V V P I+ ++S+ + L C +
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQS 2127
Query: 160 TGRPEPTVTW---RHISPKAVGF-VSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
P PT+TW H K G +SE+ L+I+ + +G Y C A+N VA +
Sbjct: 2128 DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN-VAGKTEKN 2186
Query: 215 VKVTVNYPPYI---SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
V + PP I E V G +L CE+S +P W K ++ G +V
Sbjct: 2187 YNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG-RV 2245
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+L + D Y+CVASN G
Sbjct: 2246 RILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 65.1 bits (157), Expect = 9e-11
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 14/212 (6%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
+++I V + DEG Y C + ++ V P ++++ +++++ G LTC+
Sbjct: 483 NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCL 542
Query: 159 ATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 211
+ +TW R P + ++ + LE++ + +G+Y C S++ +
Sbjct: 543 IISAVDYNLTWQRNDRDVRLAEPARIRTLA-NLSLELKSVKFNDAGEYHCMVSSEGGSSA 601
Query: 212 VRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
V +TV PP ++ K G + ++ C A+ P + W +D ++ +
Sbjct: 602 A-SVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRM 660
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ L N + D G Y C+ASN G
Sbjct: 661 TSD----GTLFIKNAAPKDAGIYGCLASNSAG 688
Score = 64.3 bits (155), Expect = 2e-10
Identities = 58/227 (25%), Positives = 91/227 (40%), Gaps = 16/227 (7%)
Query: 102 IQNVDVYDEGPYTC----SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
I+N D G Y C S TD T R +PK++ + S++ + G+ + C
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI----EAPKLMVVQSELLVALGDITVMEC 723
Query: 158 IATGRPEPTVTW--RHISPKAVGFVSEDEYLEIQGITREQ---SGDYECSASNDVAAPVV 212
+G P P V W + + F+ D L + I Q +GDY C A N+ A
Sbjct: 724 KTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINE-AGRAT 782
Query: 213 RRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK-GVK 270
++ + V PP +I E + +G TL C P +W + D I + V
Sbjct: 783 GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVS 842
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
++ L N+ D G Y C A N+ G + + G V+
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVA 889
Score = 62.0 bits (149), Expect = 7e-10
Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 17/232 (7%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNNISL 155
++I V D G YTC + + + + V V P I +SD +++ + +
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892
Query: 156 TCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
C+++G P P +W+ + F+S L+I G Y C A N A
Sbjct: 2893 ECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAEN-TAGS 2951
Query: 211 VVRRVKVTVNYPPYI--SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + V+ PP + +++ V V +L CE S P + W K+++ + K
Sbjct: 2952 AKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPI---KLN 3008
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA--SIMLFGPGAVSE 318
P L D G YTC+A N+ G + S+ ++ P ++ +
Sbjct: 3009 TNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKD 3060
Score = 53.5 bits (127), Expect = 3e-07
Identities = 55/230 (23%), Positives = 83/230 (36%), Gaps = 30/230 (13%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE--------ISSDISINEG 150
+++I N + G Y+C + + V + P I + ++ I
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689
Query: 151 NNISLTCIATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
N ++L C A P +++W S V + L+I+ +G Y C ASN
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN 2749
Query: 206 DVAAPVVRRVKVTVNYPPYISEAKGTG--VPVGQKG-----------TLQCEASAVPSAE 252
+A V + PP + G + G+ G +L CE +A P
Sbjct: 2750 -IAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPT 2808
Query: 253 FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
WYKD L KV P L D G YTCVA N+ G
Sbjct: 2809 LTWYKDGHPLTSSD---KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Score = 52.8 bits (125), Expect = 5e-07
Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 14/168 (8%)
Query: 50 GESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
G +A L C + T NR + + R+ L N S+ I D
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIE------ISHRIRQLGNG----SLAIYGTVNED 4413
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
G YTC + + L +Q P I + IN G I L C ATG P+PT+TW
Sbjct: 4414 AGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473
Query: 170 ----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
IS V + L I +E + ++EC A N + + +VR
Sbjct: 4474 SRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVR 4521
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 102 bits (255), Expect = 4e-22
Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 28/284 (9%)
Query: 44 NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
N T G+S TL C + ++W + D D + + ++ + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ VD DE Y C + + + +HL V PKI + + ++ ++LTC A+G
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
Query: 163 PEPTVTWR---------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
P P++TWR H+ ++ VS L ++ I +G+Y C+ASN +
Sbjct: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS---LTLKSIQYTDAGEYICTASNTI 391
Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK- 266
+ + + V Y P + G + + CE A PSA W++D + L
Sbjct: 392 GQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+K+ N P S L SE+D+GNY C A N++G + +L
Sbjct: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
Score = 89.7 bits (221), Expect = 3e-18
Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)
Query: 50 GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
GES C + D + ++W + + N + R+ ++ N + ++ I N ++
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88
Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
D G Y C V T S + V++ K++ + EG + + C P
Sbjct: 89 DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147
Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
T+ W+H I K V F V + YL+I+GI + G Y C + + ++V
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
VN PP I + +GQ TL C+A P W KD +++ + + K
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
S+L V ++D Y C+A NK G +A+I L F ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
Score = 52.4 bits (124), Expect = 6e-07
Identities = 54/245 (22%), Positives = 100/245 (40%), Gaps = 38/245 (15%)
Query: 51 ESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
E TL C + + + W R++ +++ LD +V+ S+ + S+ ++++ D
Sbjct: 323 EQVTLTCEASGDPIPSITW--RTSTRNISSEEKTLDGHMVVRSHARVS-SLTLKSIQYTD 379
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN--EGNNISLTCIATGRPEPTV 167
G Y C+ + ++L VQ +PK+ +++ EGN +++TC P T+
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATI 436
Query: 168 TW---------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
+W + S + YLE+ + G+Y C+A N + + + V
Sbjct: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496
Query: 219 VNYP---------PYIS---------EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
+ P PY S EA G GVP+ K + A +WY +
Sbjct: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVPI-LKYKAEWRAVGEEVWHSKWYDAKE 554
Query: 261 RLIEG 265
+EG
Sbjct: 555 ASMEG 559
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 102 bits (255), Expect = 4e-22
Identities = 73/284 (25%), Positives = 123/284 (43%), Gaps = 28/284 (9%)
Query: 44 NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
N T G+S TL C + ++W + D D + + ++ + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ VD DE Y C + + + +HL V PKI + + ++ ++LTC A+G
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
Query: 163 PEPTVTWR---------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
P P++TWR H+ ++ VS L ++ I +G+Y C+ASN +
Sbjct: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS---LTLKSIQYTDAGEYICTASNTI 391
Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK- 266
+ + + V Y P + G + + CE A PSA W++D + L
Sbjct: 392 GQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+K+ N P S L SE+D+GNY C A N++G + +L
Sbjct: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
Score = 89.7 bits (221), Expect = 3e-18
Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)
Query: 50 GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
GES C + D + ++W + + N + R+ ++ N + ++ I N ++
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88
Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
D G Y C V T S + V++ K++ + EG + + C P
Sbjct: 89 DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147
Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
T+ W+H I K V F V + YL+I+GI + G Y C + + ++V
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
VN PP I + +GQ TL C+A P W KD +++ + + K
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
S+L V ++D Y C+A NK G +A+I L F ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
Score = 52.4 bits (124), Expect = 6e-07
Identities = 54/245 (22%), Positives = 100/245 (40%), Gaps = 38/245 (15%)
Query: 51 ESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYD 109
E TL C + + + W R++ +++ LD +V+ S+ + S+ ++++ D
Sbjct: 323 EQVTLTCEASGDPIPSITW--RTSTRNISSEEKTLDGHMVVRSHARVS-SLTLKSIQYTD 379
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN--EGNNISLTCIATGRPEPTV 167
G Y C+ + ++L VQ +PK+ +++ EGN +++TC P T+
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATI 436
Query: 168 TW---------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
+W + S + YLE+ + G+Y C+A N + + + V
Sbjct: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496
Query: 219 VNYP---------PYIS---------EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
+ P PY S EA G GVP+ K + A +WY +
Sbjct: 497 ADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVPI-LKYKAEWRAVGEEVWHSKWYDAKE 554
Query: 261 RLIEG 265
+EG
Sbjct: 555 ASMEG 559
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 99.0 bits (245), Expect = 6e-21
Identities = 73/291 (25%), Positives = 123/291 (42%), Gaps = 32/291 (10%)
Query: 44 NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
N T G+S TL C + ++W + D D + + ++ + I
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DEKYIFSDDSS---QLTI 274
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
+ VD DE Y C + + + +HL V PKI + + ++ ++LTC A+G
Sbjct: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
Query: 163 PEPTVTW----RHISPKAVGFVSEDE------------------YLEIQGITREQSGDYE 200
P P++TW R+IS + + E L ++ I +G+Y
Sbjct: 335 PIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
Query: 201 CSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
C+ASN + + + + V Y P + G + + CE A PSA W++D +
Sbjct: 395 CTASNTIGQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 453
Query: 261 RLIEGK-KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L +K+ N P S L SE+D+GNY C A N++G + +L
Sbjct: 454 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 504
Score = 89.7 bits (221), Expect = 3e-18
Identities = 74/291 (25%), Positives = 124/291 (42%), Gaps = 22/291 (7%)
Query: 50 GESATLRCTI--DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
GES C + D + ++W + + N + R+ ++ N + ++ I N ++
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-----RISVVWNDDSSSTLTIYNANI 88
Query: 108 YDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCIATGRPEP 165
D G Y C V T S + V++ K++ + EG + + C P
Sbjct: 89 DDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPP 147
Query: 166 TVTWRH-----ISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPV-VRRVKVT 218
T+ W+H I K V F V + YL+I+GI + G Y C + + ++V
Sbjct: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
Query: 219 VNYPPYISEAK---GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
VN PP I + +GQ TL C+A P W KD +++ + + K
Sbjct: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML--FGPGAVSEVSNGTS 324
S+L V ++D Y C+A NK G +A+I L F ++ V N T+
Sbjct: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
Score = 48.5 bits (114), Expect = 9e-06
Identities = 48/211 (22%), Positives = 86/211 (40%), Gaps = 35/211 (16%)
Query: 84 LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
LD +V+ S+ + S+ ++++ D G Y C+ + ++L VQ +PK+
Sbjct: 365 LDGHMVVRSHARVS-SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QG 420
Query: 144 DISIN--EGNNISLTCIATGRPEPTVTW---------RHISPKAVGFVSEDEYLEIQGIT 192
+++ EGN +++TC P T++W + S + YLE+ +
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
Query: 193 REQSGDYECSASNDVAAPVVRRVKVTVNYP---------PYIS---------EAKGTGVP 234
G+Y C+A N + + + V + P PY S EA G GVP
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATG-GVP 539
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+ K + A +WY + +EG
Sbjct: 540 I-LKYKAEWRAVGEEVWHSKWYDAKEASMEG 569
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 17/282 (6%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
+F + D + V G + T + V+W S+ L G D V L ++
Sbjct: 7776 SFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPG------DRCNVSLEDSV 7829
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
+ +E+ +VD G YTC V + + HL ++ K V+ +D SI +G + L
Sbjct: 7830 AE--LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLIL 7887
Query: 156 TCIATGRPEPTVTWR----HISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
TG P +VTW+ +++P + + LEI T E +G Y C N
Sbjct: 7888 EGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASG 7947
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + P ++ + + V VG +LQC+ + P WYK D +L
Sbjct: 7948 KDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKL-RPTTT 8006
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K+ R ++ L+F V +D G Y C A N +G +AS L
Sbjct: 8007 YKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFL 8048
Score = 95.9 bits (237), Expect = 5e-20
Identities = 79/274 (28%), Positives = 115/274 (41%), Gaps = 20/274 (7%)
Query: 44 NVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
++ V GESA C + + R+ W + + G + + + NT + I
Sbjct: 6279 SIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNY-----TITCVGNTP---HLRI 6330
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCIATG 161
V D G YTC D L V+ PK V+ + + +G +I L C +G
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISG 6390
Query: 162 RPEPTVTW------RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
PE V+W H S K + F++ L I + E SGDY C A N V
Sbjct: 6391 SPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCST 6450
Query: 215 VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
+TV PP ++ G G LQCE S P E W KD K++ KK K+ +
Sbjct: 6451 A-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKK-FKITS 6508
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
+ F + L N+ D G Y C A+N++G S
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCS 6542
Score = 94.0 bits (232), Expect = 2e-19
Identities = 61/217 (28%), Positives = 98/217 (45%), Gaps = 21/217 (9%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCI 158
+ + +VD G YTC V D + L+V PK V+ + + + G++ L C
Sbjct: 5387 LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECK 5446
Query: 159 ATGRPEPTVTW---RHISPKA----VGFVSEDEYLEIQGITREQSGDYECSASNDVAAP- 210
G PE V W H P + + F+ +++ ++ E SGD+ C A N +
Sbjct: 5447 IAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTS 5506
Query: 211 -----VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+V+ V ++PP + K V +L+CE S P E WYKD ++L
Sbjct: 5507 CSTKVIVKEPPVFSSFPPIVETLKNAEV------SLECELSGTPPFEVVWYKDKRQLRSS 5560
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
KK K+ ++ F + + NV D G Y C A N++G
Sbjct: 5561 KK-YKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG 5596
Score = 92.0 bits (227), Expect = 7e-19
Identities = 72/275 (26%), Positives = 113/275 (41%), Gaps = 20/275 (7%)
Query: 38 FPKAMDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAGND-KWCLDPRVVLLSNTQ 95
F K ++ V + L C +D +R V W L G D K C + ++ L
Sbjct: 3646 FIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATL---- 3701
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNIS 154
EI + D G Y C+ + + + V+ P V+ + + G +
Sbjct: 3702 -----EIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESAR 3756
Query: 155 LTCIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
L C G P VTW + +S + FV+ + L+I + E SG Y C A NDV
Sbjct: 3757 LHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDV 3816
Query: 208 AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ V P +I + + G LQCE S E W+KD K++ KK
Sbjct: 3817 GSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKK 3876
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
++ ++ L L F+ + D G Y CV +N++G
Sbjct: 3877 -YRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Score = 89.4 bits (220), Expect = 4e-18
Identities = 57/214 (26%), Positives = 95/214 (44%), Gaps = 8/214 (3%)
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
T +E+ N+D+ G YTC V + + L V+ ++ SD S+ G +I L
Sbjct: 5946 TVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIIL 6005
Query: 156 TCIATGRPEPTVTWRH-----ISPKAVGFVSEDE--YLEIQGITREQSGDYECSASNDVA 208
TG +VTW+ + + V+ ++ LEI T+ +G Y C N+
Sbjct: 6006 ESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
V + T+ P +++E + VG +LQC+ + P WYK D +L
Sbjct: 6066 RDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKL-RPTPE 6124
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ ++ L+F V+ +D G YTC A N +G
Sbjct: 6125 YRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 89.4 bits (220), Expect = 4e-18
Identities = 71/282 (25%), Positives = 114/282 (40%), Gaps = 17/282 (6%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
+F + D+V V G S T I +V W S L G C + L +
Sbjct: 6835 SFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGES--CN----ISLEDFV 6888
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
T+ +E+ V + G Y+C V D + HL V+ V+ +D S+ G+ I L
Sbjct: 6889 TE--LELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVL 6946
Query: 156 TCIATGRPEPTVTWRH----ISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
TG P +V+W IS ++ + LEI T E Y C N+
Sbjct: 6947 EATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAG 7006
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + + P +I + +G+ TLQC+ P WYK+ +L
Sbjct: 7007 QDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL-RSAPA 7065
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K++ + ++ L+ V D G Y+C A N +G +S +L
Sbjct: 7066 YKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL 7107
Score = 87.8 bits (216), Expect = 1e-17
Identities = 73/275 (26%), Positives = 108/275 (39%), Gaps = 32/275 (11%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
+V + GES T +C + ++ W + + G + ++ L+ NT T + +
Sbjct: 7220 SVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNY-----KMTLVENTAT---LTV 7271
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTCIATG 161
V D G YTC + L VQ P+ ++ + + + C G
Sbjct: 7272 LKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGG 7331
Query: 162 RPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
PE V W + S + FV LE+ ++ E SGDY C A N A
Sbjct: 7332 SPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHN-AAGSASSS 7390
Query: 215 VKVTVNYPPY-------ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ V PP I KG V L+CE P WYKD + L GKK
Sbjct: 7391 TSLKVKEPPIFRKKPHPIETLKGADV------HLECELQGTPPFHVSWYKDKRELRSGKK 7444
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
K+ + FL+ + NV D G Y C A+N +G
Sbjct: 7445 -YKIMSENFLTSIHILNVDAADIGEYQCKATNDVG 7478
Score = 85.1 bits (209), Expect = 8e-17
Identities = 63/241 (26%), Positives = 101/241 (41%), Gaps = 14/241 (5%)
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI-NEGNNIS 154
T S+E+ D G Y C + D TS+ L V+ P+ ++ S + + G + +
Sbjct: 4821 TSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTT 4880
Query: 155 LTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
C TG P+ V+W I + F+ +I G E SG Y C A ND
Sbjct: 4881 FECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARND- 4939
Query: 208 AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
A +++ V PP +I E K V L+CE + P E W K+++ + K
Sbjct: 4940 AGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSK 4999
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---GPGAVSEVSNGT 323
K + +R + L D G Y C+ SN+ G + S + P + ++ N T
Sbjct: 5000 K-YTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT 5058
Query: 324 S 324
+
Sbjct: 5059 T 5059
Score = 84.0 bits (206), Expect = 2e-16
Identities = 73/286 (25%), Positives = 123/286 (43%), Gaps = 22/286 (7%)
Query: 37 TFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
+F K ++N T SAT + T+ + + WL IL ++ V +S
Sbjct: 5049 SFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDN--------VYISFVD 5100
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
+ +++I++VD G YTC + ++ + L+VQ +IVE + + + E + ++L
Sbjct: 5101 SVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTL 5160
Query: 156 TCIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDV- 207
C+ G PE V W + I P ++ F + IQ + ++ SG Y ND
Sbjct: 5161 ECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220
Query: 208 --AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
+ RV + N PP + + +G ++C+ S QW+KD K +
Sbjct: 5221 SSSCDAYLRV-LDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIST 5279
Query: 265 GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K V + +S L N+ D NYTC SN G S +L
Sbjct: 5280 SAKYRLVCHERSVS-LEVNNLELEDTANYTCKVSNVAGDDACSGIL 5324
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/284 (22%), Positives = 115/284 (40%), Gaps = 19/284 (6%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
F ++++TV GE A L+ +I+ + V WL + ++ + R+ + N T
Sbjct: 5612 FVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESE----NIRITFVENVAT 5667
Query: 97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLT 156
++ + + G Y C ++ D + + L+V IVE + +++ G +L
Sbjct: 5668 ---LQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLE 5724
Query: 157 CIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV-- 207
C G PE +V W F ++ L I + R+ +G Y N+V
Sbjct: 5725 CKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784
Query: 208 -AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
+ V V P + K TG +G L+C+ + W+ + +++ G
Sbjct: 5785 SSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGA 5844
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K + + L ++ D GNYTCVA+N G +L
Sbjct: 5845 K-YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL 5887
Score = 76.3 bits (186), Expect = 4e-14
Identities = 60/241 (24%), Positives = 94/241 (39%), Gaps = 12/241 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE-ISSDISINEGNNISLTC 157
S+E+ V D G YTC V +L V+ VE + + +G+ L C
Sbjct: 4262 SLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLAC 4321
Query: 158 IATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
TG P +TW + S + FV L + + E SG+Y C A N+ +
Sbjct: 4322 KVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSD 4381
Query: 211 VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
+ + P + E K V L E + P E W+KD+ L G+K K
Sbjct: 4382 HCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRK-YK 4440
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---GPGAVSEVSNGTSRRA 327
+ L L D G Y C +N++G + S + P + ++ + +S R
Sbjct: 4441 TFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRG 4500
Query: 328 G 328
G
Sbjct: 4501 G 4501
Score = 76.3 bits (186), Expect = 4e-14
Identities = 65/288 (22%), Positives = 116/288 (40%), Gaps = 27/288 (9%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDN-RVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQ 95
F K + + + G++ LR ++ + V WL +R ++ + R+ + N
Sbjct: 6553 FVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENT-----RISFIDNIA 6607
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
T +++ + + + G Y C ++ D + L V +I+E +++ GN +L
Sbjct: 6608 T---LQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFAL 6664
Query: 156 TCIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
C+ TG PE + W R +S + + F+++ L+I G Y N V
Sbjct: 6665 ECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVG 6724
Query: 209 ---APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
V V + P +I + K +G L+C S W++D ++ G
Sbjct: 6725 KSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSG 6784
Query: 266 KKGVKVENRPFLSKLIFFNVS---EHDYGNYTCVASNKLGHTNASIML 310
K F + N+S D G YTCVA+N G S +L
Sbjct: 6785 PKC----QSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVL 6828
Score = 74.7 bits (182), Expect = 1e-13
Identities = 70/289 (24%), Positives = 112/289 (38%), Gaps = 27/289 (9%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
F + +++V GE ATL+C +D R++W T L + +
Sbjct: 7022 FIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAP--------AYKMQFKNN 7073
Query: 97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNNI 153
S+ I VD D G Y+C S L+++ + P D+ G +
Sbjct: 7074 VASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPV 7133
Query: 154 SLTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
+ C G V+W + + FV L+I + G Y CSASN
Sbjct: 7134 AFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNP 7193
Query: 207 V--AAPVVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI 263
+ A+ + + PP+ + + +G+ GT +C + + W KD++ +
Sbjct: 7194 LGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIR 7253
Query: 264 EGK--KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G K VEN L+ L V + D G YTC ASN G + S L
Sbjct: 7254 PGGNYKMTLVENTATLTVL---KVGKGDAGQYTCYASNIAGKDSCSAQL 7299
Score = 73.9 bits (180), Expect = 2e-13
Identities = 68/279 (24%), Positives = 110/279 (39%), Gaps = 22/279 (7%)
Query: 45 VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
+TV GE+ TL C +VA ++ + + K + S S+ I +
Sbjct: 5713 MTVTVGETCTLEC-------KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILS 5765
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISI-NEGNNISLTCI----A 159
V+ D G YT VQ N+ S +V VS + V S + N G + +CI
Sbjct: 5766 VERQDAGTYTFQVQ--NNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKV 5823
Query: 160 TGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
G +V W H K V F L++ + G+Y C A+N +
Sbjct: 5824 AGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC 5883
Query: 213 RRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
R V P ++ E + V G+ T P + W++ + L++G + +
Sbjct: 5884 RAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDR-CNIY 5942
Query: 273 NRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
+++L FN+ G YTCV SN G + + LF
Sbjct: 5943 FEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLF 5981
Score = 73.2 bits (178), Expect = 3e-13
Identities = 55/218 (25%), Positives = 88/218 (40%), Gaps = 10/218 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS--PKIVEISSDISINEGNNISLT 156
S+EI V D G YTC + + L V + P + ++ G
Sbjct: 3512 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFI 3571
Query: 157 CIATGRPEPTVTWRH----ISPKAVGFVSEDE---YLEIQGITREQSGDYECSASNDVAA 209
C TG P W+ +SP +S+ E LE+ +T + G Y C ASN A
Sbjct: 3572 CTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631
Query: 210 PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
+ + + ++ P +I E + + +K L+C+ W KD ++L G K
Sbjct: 3632 DICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPG-KDY 3690
Query: 270 KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
K+ ++ L D G Y C ASN+ G ++ S
Sbjct: 3691 KICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCS 3728
Score = 71.6 bits (174), Expect = 9e-13
Identities = 56/222 (25%), Positives = 82/222 (36%), Gaps = 15/222 (6%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+EI ++ D G YTCS HL V+ P VE +N + L +
Sbjct: 4732 LEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALV 4791
Query: 160 TGRPEPTVTW----RHISPKAVGFVSEDE---YLEIQGITREQSGDYECSASNDVAAPVV 212
G T+ W + + A V +D+ LE+ SG Y C SNDV
Sbjct: 4792 GGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATS 4851
Query: 213 RRVKVTVNYPPYISEAKGTGV-PVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
+ P +I + V GQ T +C+ + P WY D + ++
Sbjct: 4852 KATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEI----TAIQK 4907
Query: 272 ENRPFLSKLIFFNVS---EHDYGNYTCVASNKLGHTNASIML 310
F+ L F +S + G Y C A N G + SI L
Sbjct: 4908 HGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 4949
Score = 70.9 bits (172), Expect = 2e-12
Identities = 64/281 (22%), Positives = 114/281 (40%), Gaps = 20/281 (7%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
TF ++T G++A CT+ V W L + + W +S+ +
Sbjct: 3552 TFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAAL-SPSPNW-------RISDAE 3603
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
++ +E+ N+ + D G Y+C + LI+ P ++ + + L
Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHL 3663
Query: 156 TCIATGRPEPTVTWRHISPK-------AVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
C + TVTW K + F + LEI + SG Y C+ASN+
Sbjct: 3664 ECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAG 3723
Query: 209 APVVRRVKVTVNYPP-YISEAKGTGVPV-GQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
+ VTV PP ++ + + + + G+ L C+ P + W+K++K L E
Sbjct: 3724 SSSC-SATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESN 3782
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
V++ + L +V D G+Y+C A N +G + S
Sbjct: 3783 T-VRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCS 3822
Score = 70.1 bits (170), Expect = 3e-12
Identities = 67/288 (23%), Positives = 111/288 (38%), Gaps = 25/288 (8%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
F K ++ V V G+SA+L+C + V+W Y G+ K L P + +
Sbjct: 7963 FVKQLEPVKVSVGDSASLQCQLAGTPEIGVSW-------YKGDTK--LRPTTTYKMHFRN 8013
Query: 97 QYSIEIQN-VDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNN 152
+ + N VD+ D G Y C + ++ L VQ + P D+ G
Sbjct: 8014 NVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLP 8073
Query: 153 ISLTCIATGRPEPTVTWRHI------SPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
+ C +G +V+W SP F+ L I R +G Y C+A+N
Sbjct: 8074 VVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATN 8133
Query: 206 DV--AAPVVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
+ A+ R + PP+ VG+ +C + + W KD + +
Sbjct: 8134 PIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREI 8193
Query: 263 IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G K ++ + L V + D G YTC A N++G + + L
Sbjct: 8194 RSGGK-YQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQL 8240
Score = 69.7 bits (169), Expect = 4e-12
Identities = 63/282 (22%), Positives = 110/282 (39%), Gaps = 18/282 (6%)
Query: 47 VRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNV 105
V+ G+S+ L C I + RV W L A +DK+ R+ + + I++ N+
Sbjct: 5435 VKAGDSSRLECKIAGSPEIRVVWFRNEHELPA-SDKY----RMTFIDSVAV---IQMNNL 5486
Query: 106 DVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEP 165
D G + C Q + +IV+ P + + +SL C +G P
Sbjct: 5487 STEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPF 5546
Query: 166 TVTW----RHI-SPKAVGFVSEDEYLEIQGITREQS--GDYECSASNDVAAPVVRRVKVT 218
V W R + S K S++ + I + + S G+Y C A N+V +
Sbjct: 5547 EVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKL 5606
Query: 219 VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
P ++S+ V G+ LQ QW K+ + +I + +++ ++
Sbjct: 5607 KEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVA 5666
Query: 279 KLIFFNVSEHDYGNYTCVASNKLG--HTNASIMLFGPGAVSE 318
L F + G Y C N G A++M+ P + E
Sbjct: 5667 TLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVE 5708
Score = 69.7 bits (169), Expect = 4e-12
Identities = 53/220 (24%), Positives = 80/220 (36%), Gaps = 9/220 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
SI I NVD D G Y C D T + ++ P+ V+ SDIS G + L
Sbjct: 7455 SIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTT 7514
Query: 159 ATGRPEPTVTW--------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210
G +V W R + + L+ + +G Y C ND
Sbjct: 7515 IEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQ 7574
Query: 211 VVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
+ + + + V G TL+C + P +W+KD K L K K
Sbjct: 7575 ECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK-YK 7633
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+ +S L NV+ D G Y+ N +G + + L
Sbjct: 7634 ISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL 7673
Score = 69.3 bits (168), Expect = 5e-12
Identities = 59/285 (20%), Positives = 111/285 (38%), Gaps = 21/285 (7%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNR--VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
F K + +++ G+ L+ TI+ ++ V + ++ I+ ++ W +S ++
Sbjct: 7494 FVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW--------ISYSE 7545
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 155
+++ V+ + G YTC ++ D + L V IVE I + G+ +L
Sbjct: 7546 NIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTL 7605
Query: 156 TCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDV- 207
C G PE + W + + F ++ L+I + SG Y N V
Sbjct: 7606 ECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG 7665
Query: 208 --AAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+ +V P + + K T G ++C+ P W+ + + G
Sbjct: 7666 KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+K + L + E D G+YTC+A+N G S L
Sbjct: 7726 RK-YQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPL 7769
Score = 68.6 bits (166), Expect = 8e-12
Identities = 55/237 (23%), Positives = 96/237 (40%), Gaps = 27/237 (11%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS---PKIVEISSDISINEGNNISLT 156
++++ + D G YTC V D ++++ P + + ++++EG + L+
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLS 8366
Query: 157 CIATGRPEPTVTW----RHISPK---AVGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
C G + W R I P + F S LE++ + + SGDY C ASN VA
Sbjct: 8367 CHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASN-VAG 8425
Query: 210 PVVRRVKVTVNYPP----------------YISEAKGTGVPVGQKGTLQCEASAVPSAEF 253
+ KVT+ P ++SE + V T + P
Sbjct: 8426 SDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNV 8485
Query: 254 QWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+W K R + V + + +KL + ++ D G Y CVA N+ G +++ L
Sbjct: 8486 KWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNL 8542
Score = 68.2 bits (165), Expect = 1e-11
Identities = 53/228 (23%), Positives = 89/228 (39%), Gaps = 9/228 (3%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+E+ N+ V D G YTC +S L V+ P + I +G ++ L C
Sbjct: 7363 LEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECEL 7422
Query: 160 TGRPEPTVTW----RHI-SPKAVGFVSED--EYLEIQGITREQSGDYECSASNDVAAPVV 212
G P V+W R + S K +SE+ + I + G+Y+C A+NDV +
Sbjct: 7423 QGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTC 7482
Query: 213 RRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVE 272
P ++ + VG++ LQ W+KD ++ + +
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWIS 7542
Query: 273 NRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN--ASIMLFGPGAVSE 318
++ L F V + G YTC N G A++ + P + E
Sbjct: 7543 YSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVE 7590
Score = 67.4 bits (163), Expect = 2e-11
Identities = 68/290 (23%), Positives = 108/290 (37%), Gaps = 26/290 (8%)
Query: 36 ATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNT 94
AT + +++ V G++ TL CT+ W L + N +S
Sbjct: 7586 ATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK--------YKISFF 7637
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
++I NV D G Y+ VQ + L QVS + V S + E N +S
Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL--QVSDRTVPPSFTRKLKETNGLS 7695
Query: 155 -----LTCIATGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGDYECS 202
+ C G P +V+W H + L + + SGDY C
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755
Query: 203 ASNDVAAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
A+N +A +TV PP ++ + V G T P W+K
Sbjct: 7756 ATN-MAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSE 7814
Query: 262 LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
L+ G + V +++L F+V G YTC+ SN+ G + + L+
Sbjct: 7815 LVPGDR-CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLY 7863
Score = 67.0 bits (162), Expect = 2e-11
Identities = 72/292 (24%), Positives = 106/292 (36%), Gaps = 33/292 (11%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDP--RVVLLSNT 94
F ++ + G+S +L+C + V+W Y G+ K P R +N
Sbjct: 6081 FVTELEPLEAAVGDSVSLQCQVAGTPEITVSW-------YKGDTKLRPTPEYRTYFTNNV 6133
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGN 151
T + V++ D G YTC + +S+ +Q + P DI G
Sbjct: 6134 AT---LVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL 6190
Query: 152 NISLTCIATGRPEPTVTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSAS 204
++LTC G V W R FV L+I SG Y CSAS
Sbjct: 6191 PVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSAS 6250
Query: 205 NDVAAPVVRRVKVTVNYP---PYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
N + ++T P P+ + V G+ +C + W KD+K
Sbjct: 6251 NPLGT-ASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNK 6309
Query: 261 RLIEGKKGVK--VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+ G V N P L L V + D G YTC A+N +G S L
Sbjct: 6310 EIRPGGNYTITCVGNTPHLRIL---KVGKGDSGQYTCQATNDVGKDMCSAQL 6358
Score = 66.6 bits (161), Expect = 3e-11
Identities = 77/315 (24%), Positives = 115/315 (36%), Gaps = 31/315 (9%)
Query: 36 ATFPKAMDNVTVRQGESATLRCTIDNRVTRVA-WLNRSTILYAGNDKWCLDPRVVLLSNT 94
AT + ++ V QG+ ATL+ A W L G+ +S T
Sbjct: 4579 ATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSK--------YKISVT 4630
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGN 151
T ++I + + D G YT VQ D + + + V + P + + +G+
Sbjct: 4631 DTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGS 4690
Query: 152 NISLTCIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSAS 204
I L CI G ++ W + IS F +LEI + SG Y CSA+
Sbjct: 4691 FIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSAT 4750
Query: 205 NDVAAPVVRRVKVTVNYPPY-ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI 263
N A +TV PPY + + + V + L+ +W+KD+K L
Sbjct: 4751 NK-AGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELH 4809
Query: 264 EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF---------GPG 314
G V + L F D G Y C SN +G + LF P
Sbjct: 4810 SG-AARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPS 4868
Query: 315 AVSEVSNGTSRRAGC 329
V + NG S C
Sbjct: 4869 PVLVLRNGQSTTFEC 4883
Score = 66.2 bits (160), Expect = 4e-11
Identities = 69/280 (24%), Positives = 110/280 (39%), Gaps = 20/280 (7%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96
F K + NV + L C I + RV+W + A +D++ R+ + T
Sbjct: 4115 FTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEI-AASDRY----RIAFVEGTA- 4168
Query: 97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLT 156
S+EI VD+ D G +TC K S LIVQ P V + G+ + L
Sbjct: 4169 --SLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK 4226
Query: 157 CIATGRPEPTVTWRHISPKAVG----FVSE---DEYLEIQGITREQSGDYECSASNDVAA 209
G T+ W + + V ++++ + LE+ + SG Y C SN VA
Sbjct: 4227 STFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSN-VAG 4285
Query: 210 PVVRRVKVTVNYPPYISEAKGTG--VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
V + V P E + G L C+ + P + W+ +D+ + E K
Sbjct: 4286 GVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK 4345
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
++ + L +V D G Y C A N+ G + S
Sbjct: 4346 H-RMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCS 4384
Score = 66.2 bits (160), Expect = 4e-11
Identities = 61/267 (22%), Positives = 103/267 (38%), Gaps = 19/267 (7%)
Query: 45 VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ +R G+S T C I RV+W GN+ + + + + +I
Sbjct: 4871 LVLRNGQSTTFECQITGTPKIRVSWY------LDGNEITAIQKHGISFIDGLATF--QIS 4922
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRP 163
V + G Y C + D + + L V+ P + + + + +++ L C TG P
Sbjct: 4923 GARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTP 4982
Query: 164 EPTVTW----RHI-SPKAVGFVSEDEY--LEIQGITREQSGDYECSASNDVAAPVVRRVK 216
VTW R I S K L I +G+Y+C SN+ +
Sbjct: 4983 PFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNE-GGSCSCSTR 5041
Query: 217 VTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRP 275
V + PP +I + + T + T Q + P W KDD ++++ V +
Sbjct: 5042 VALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDD-QILDEDDNVYISFVD 5100
Query: 276 FLSKLIFFNVSEHDYGNYTCVASNKLG 302
++ L +V G YTC A N+ G
Sbjct: 5101 SVATLQIRSVDNGHSGRYTCQAKNESG 5127
Score = 64.7 bits (156), Expect = 1e-10
Identities = 73/306 (23%), Positives = 117/306 (38%), Gaps = 50/306 (16%)
Query: 45 VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
VTV+ G+ A I R +++W +L G + L + Q +Y++ +
Sbjct: 3248 VTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF-------KCKFLHDGQ-EYTLLLI 3299
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS-------------PKIVEISSDISINEG 150
D YTC + D T+ L V+V P I+ D +EG
Sbjct: 3300 EAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEG 3359
Query: 151 NNISLTCIATGRPEPTVTW----RHISPKAVGFVS--EDEY-LEIQGITREQSGDYECSA 203
C +G + V+W + I P ++ ED Y LEI E G Y A
Sbjct: 3360 QPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA 3418
Query: 204 SNDVA-----------AP-------VVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCE 244
SN V AP + + +++ + P I + + V +G CE
Sbjct: 3419 SNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT 304
+ P+ FQW+K + + E K + + ++S L D G YTC ASN+ G
Sbjct: 3479 IQSAPNVRFQWFKAGREIYESDK-CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSV 3537
Query: 305 NASIML 310
+ + L
Sbjct: 3538 SCTATL 3543
Score = 64.3 bits (155), Expect = 2e-10
Identities = 68/290 (23%), Positives = 109/290 (37%), Gaps = 42/290 (14%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
D VT +G+ A +C + +V+W ++ DK R ++ + Y +EI
Sbjct: 3353 DTVT-SEGQPARFQCRVSGTDLKVSWYSK--------DKKIKPSRFFRMTQFEDTYQLEI 3403
Query: 103 QNVDVYDEGPYTC------------------SVQTDNHPKTSR-VHLIVQVSPKIVEISS 143
DEG YT + ++ H + + + + ++ +P I
Sbjct: 3404 AEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIE 3463
Query: 144 DISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQ---S 196
+ + G+ TC P W R I + +Y+ I R Q
Sbjct: 3464 PLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDC 3523
Query: 197 GDYECSASNDV-AAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQ 254
G+Y C ASN+ + + VT YPP ++S K VG+ C + P E
Sbjct: 3524 GEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETI 3583
Query: 255 WYKDDKRLIEGK--KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
W KD L + EN+ L N++ D G Y+C ASNK G
Sbjct: 3584 WQKDGAALSPSPNWRISDAENKHILE---LSNLTIQDRGVYSCKASNKFG 3630
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/283 (21%), Positives = 110/283 (38%), Gaps = 22/283 (7%)
Query: 37 TFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYA-GNDKWCLDPRVVLLSNT 94
TF K +D++ G++ TL+ + + V W+ ++ G K V +L
Sbjct: 3925 TFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLI-- 3982
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
I +V + G YTC + + +TS LIV+ KI+E + I + G+ +
Sbjct: 3983 -------IPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPAT 4035
Query: 155 LTCIATGRPEPTVTWRH-----ISPK--AVGFVSEDEYLEIQGITREQSGDYECSASNDV 207
L G PE W ++ K + F + L+ SG Y SN+V
Sbjct: 4036 LEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEV 4095
Query: 208 AAPVVRRVKVTVN---YPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE 264
+ ++ P + + V L C+ + W+KD K +
Sbjct: 4096 GSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAA 4155
Query: 265 GKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
+ ++ + L V +D GN+TC A+N +G ++S
Sbjct: 4156 SDR-YRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSS 4197
Score = 63.2 bits (152), Expect = 3e-10
Identities = 44/217 (20%), Positives = 85/217 (39%), Gaps = 9/217 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+E+ N+++ D YTC V L V+ P + + + I
Sbjct: 5293 SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAI 5352
Query: 159 ATGRPEPTVTWRH------ISPKA-VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 211
G P + W PK +G +L + + ++G Y C +NDV +
Sbjct: 5353 LKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 5412
Query: 212 VRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 270
+ + P ++ + + + V G L+C+ + P W++++ L K +
Sbjct: 5413 CTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDK-YR 5471
Query: 271 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
+ ++ + N+S D G++ C A N G T+ S
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCS 5508
Score = 62.0 bits (149), Expect = 7e-10
Identities = 64/285 (22%), Positives = 105/285 (36%), Gaps = 29/285 (10%)
Query: 32 RSGDATFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVL 90
R+ +F + + N G S L C + + VAW + T + +G
Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSG------------ 5843
Query: 91 LSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDI 145
+ QT +S +++ ++D D G YTC R L VQ P V+ +
Sbjct: 5844 -AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPL 5902
Query: 146 SINEGNNISLTCIATGRPEPTVTWRHISPKAVG-------FVSEDEYLEIQGITREQSGD 198
+ G N++ T + G P V W + + V F LE+ I QSG+
Sbjct: 5903 EVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGE 5962
Query: 199 YECSASNDVAAPVVRRVKVTVNYP-PYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
Y C SN+ A ++ V P ++ V G+ L+ + W K
Sbjct: 5963 YTCVVSNN-AGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKK 6021
Query: 258 DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
D + +K + L N ++ D G Y+C N+ G
Sbjct: 6022 DGFNITTSEK-CNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065
Score = 62.0 bits (149), Expect = 7e-10
Identities = 54/271 (19%), Positives = 94/271 (34%), Gaps = 16/271 (5%)
Query: 48 RQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
+QGES L C I +V+W + L+ + W + +S + + I
Sbjct: 6377 KQGESIQLECKISGSPEIKVSWFRNDSELH---ESWKYN-----MSFINSVALLTINEAS 6428
Query: 107 VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPT 166
D G Y C + L V+ P + S + +G+++ L C +G P
Sbjct: 6429 AEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFE 6488
Query: 167 VTW-------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
V W R+ + D L I + G+Y C A+N+V +
Sbjct: 6489 VVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548
Query: 220 NYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
P ++ + T +G L+ W KD +I + ++ ++
Sbjct: 6549 EPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIAT 6608
Query: 280 LIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L + + G Y C N G S +L
Sbjct: 6609 LQLGSPEASNSGKYICQIKNDAGMRECSAVL 6639
Score = 60.5 bits (145), Expect = 2e-09
Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 20/249 (8%)
Query: 66 VAWLNRSTILYAGND-KWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPK 124
+ W +TIL +G K + +V S++I D G Y C V +
Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLV---------SLQILKFVAADAGEYQCRVTNEVGSS 4474
Query: 125 TSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKA-------V 177
+ ++ P ++ S G + G TVTW S + +
Sbjct: 4475 ICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRM 4534
Query: 178 GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISE-AKGTGVPVG 236
F + L + GI + G Y C A ND + ++V P I+E A V G
Sbjct: 4535 TFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSAL-LSVKEPATITEEAVSIDVTQG 4593
Query: 237 QKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCV 296
TLQ + S +W+KD + L G K K+ +S L + + D G YT
Sbjct: 4594 DPATLQVKFSGTKEITAKWFKDGQELTLGSK-YKISVTDTVSILKIISTEKKDSGEYTFE 4652
Query: 297 ASNKLGHTN 305
N +G ++
Sbjct: 4653 VQNDVGRSS 4661
Score = 60.5 bits (145), Expect = 2e-09
Identities = 68/282 (24%), Positives = 113/282 (40%), Gaps = 28/282 (9%)
Query: 44 NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
+V V + + TL C + +V WL + K + R +S S I
Sbjct: 5149 SVDVTEKDPMTLECVVAGTPELKVKWLK--------DGKQIVPSRYFSMSFENNVASFRI 5200
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIV---QVSPKIVEISSDISINEGNNISLTCIA 159
Q+V D G YT V+ D + +L V + P + + + G++I + C
Sbjct: 5201 QSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260
Query: 160 TGRPEPTVTW----RHISPKAVGFVSEDEY---LEIQGITREQSGDYECSASNDVAAPVV 212
+G + W + IS A + E LE+ + E + +Y C SN VA
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSN-VAGDDA 5319
Query: 213 RRVKVTVNYPP--YISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYKDDKRLIEGKKG 268
+TV PP + + +P T++ +A P + +W+KDD L+ G K
Sbjct: 5320 CSGILTVKEPPSFLVKPGRQQAIP---DSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC 5376
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+ S L ++V G YTC +N +G + + ML
Sbjct: 5377 F-IGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Score = 58.5 bits (140), Expect = 8e-09
Identities = 56/285 (19%), Positives = 109/285 (38%), Gaps = 20/285 (7%)
Query: 36 ATFPKAMD-NVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSN 93
ATF + ++ + +++G++ L C + ++ W ND+ + +S
Sbjct: 4299 ATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWF--------ANDREIKESSKHRMSF 4350
Query: 94 TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
++ + + +V + D G Y C Q + +IV+ SP + I + + ++
Sbjct: 4351 VESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDV 4410
Query: 154 SLTCIATGRPEPTVTW------RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASND 206
L G P +TW K F+ + L+I +G+Y+C +N+
Sbjct: 4411 MLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNE 4470
Query: 207 VAAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
V + + +VT+ PP +I + + T G Q W KD + E
Sbjct: 4471 VGSSIC-SARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITE- 4528
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+++ ++ L + G Y C A N G S +L
Sbjct: 4529 DDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573
Score = 57.4 bits (137), Expect = 2e-08
Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 17/226 (7%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-----SDISINEGNNI 153
S++I ++ D+G Y+ V+ N S + V VS +IV S D++ G ++
Sbjct: 6701 SLKIPCAEMSDKGLYSFEVK--NSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASV 6758
Query: 154 SLTCIATGRPEPTVTWRH------ISPKAVGFVSEDEY-LEIQGITREQSGDYECSASND 206
L C +G +V W PK SE+ L + + +G Y C A+N
Sbjct: 6759 VLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 6818
Query: 207 VAAPVVRRVKVTVNYPPYISEAKGT-GVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+ V +TV PP + + V G T P + +W+K + L+ G
Sbjct: 6819 AGSDECSAV-LTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPG 6877
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF 311
+ + F+++L F V + G+Y+C+ +N G + + LF
Sbjct: 6878 ES-CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922
Score = 56.6 bits (135), Expect = 3e-08
Identities = 54/250 (21%), Positives = 93/250 (37%), Gaps = 23/250 (9%)
Query: 81 KWCLDPRVVLLSNTQTQYSIEIQN---------VDVYDEGPYTCSVQTD---NHPKTSRV 128
KW D R ++ S +Y I +N +++D G YT + + + +T+
Sbjct: 4049 KWYKDGRPLVASK---KYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFT 4105
Query: 129 HLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPK---AVGFVS 181
L ++P + ++ L C G V+W + I+ + FV
Sbjct: 4106 VLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE 4165
Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTL 241
LEI + +G++ C A+N V + + P ++++ V G L
Sbjct: 4166 GTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCL 4225
Query: 242 QCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
+ +W+K +K L+ G + S L + V D G YTC SN
Sbjct: 4226 KSTFQGSTPLTIRWFKGNKELVSGGS-CYITKEALESSLELYLVKTSDSGTYTCKVSNVA 4284
Query: 302 GHTNASIMLF 311
G S LF
Sbjct: 4285 GGVECSANLF 4294
Score = 56.2 bits (134), Expect = 4e-08
Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 42/281 (14%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
T P++M TV +GESA C D V V WL + +L ++ T+
Sbjct: 32565 TKPRSM---TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ--------VTTTK 32613
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ---VSPKIVEISSDISINEGNN 152
+ + EI +V DEG Y+ V+ + + L +Q V+ K V +
Sbjct: 32614 YKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVK------ 32667
Query: 153 ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 212
PEP V SP+AV + + E S S + P
Sbjct: 32668 ---------SPEPRVK----SPEAVKSPKRVK-------SPEPSHPKAVSPTETKPTPTE 32707
Query: 213 RRVKVTVNYPPYISE-AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKV 271
+ + V+ PP I++ K K T E+S + + E WYKD K+L E
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH 32767
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFG 312
+ +L N++E D G Y C S + G + ++ G
Sbjct: 32768 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMG 32808
Score = 55.8 bits (133), Expect = 5e-08
Identities = 69/289 (23%), Positives = 102/289 (35%), Gaps = 52/289 (17%)
Query: 25 VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWC 83
VP V + T + NVTV +GES TL C I + V W + +
Sbjct: 932 VPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESS----- 986
Query: 84 LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
+D ++ S + I+ D G +TCS + ++ +L VQVS +
Sbjct: 987 IDFQITFQSGIA---RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF----- 1038
Query: 144 DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV-SEDEYLEIQGITREQSGDYECS 202
E T + + FV S D + +T EQ+G E +
Sbjct: 1039 ------------------EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPA 1080
Query: 203 ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
A + PVV+++ +G V G C+ P W K L
Sbjct: 1081 APYFITKPVVQKL------------VEGGSVVFG------CQVGGNPKPHVYWKKSGVPL 1122
Query: 263 IEG-KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G + V + KL+ D G YT V NK G T+AS L
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/217 (25%), Positives = 84/217 (38%), Gaps = 16/217 (7%)
Query: 116 SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW------ 169
S+ + KTS+ V+ +I S+ +SINEG + L G + V W
Sbjct: 33019 SIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD--VKWVLNGVE 33076
Query: 170 -RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNY-----PP 223
+ G D+ L I+ + G C S V + +T++ P
Sbjct: 33077 LTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC-ISKTKEGIVKCQYDLTLSKELSDAPA 33135
Query: 224 YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFF 283
+IS+ + + GQ CE S PS E +W+K++ I V + + L
Sbjct: 33136 FISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLP-ISISSNVSISRSRNVYSLEIR 33194
Query: 284 NVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVS 320
N S D G YT A N G +A+ L V E S
Sbjct: 33195 NASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPS 33231
Score = 53.9 bits (128), Expect = 2e-07
Identities = 54/282 (19%), Positives = 116/282 (41%), Gaps = 30/282 (10%)
Query: 47 VRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNV 105
+ +G++ C I + + W + + ++ V +S ++ YS+EI+N
Sbjct: 33145 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN--------VSISRSRNVYSLEIRNA 33196
Query: 106 DVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL------TCIA 159
V D G YT ++ N + V P + E S ++ + + SL +
Sbjct: 33197 SVSDSGKYT--IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQ 33254
Query: 160 TGRPEPTVTWRHISPKAVGFVSEDEY--LEIQGITREQSGDYECSASN--------DVAA 209
+ ++ S + ++E ++ + Q ++ Q E S+S+ + +
Sbjct: 33255 MSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLES 33314
Query: 210 PVVRRVKVTVNYPPYISEAKGTGVPV--GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ +K + P EA + + + G+ T+ C + P+ E W +++ ++
Sbjct: 33315 STSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ 33374
Query: 268 G-VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
G +EN L+ LI +V + D G YT N+ G +A++
Sbjct: 33375 GRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATV 33416
Score = 51.6 bits (122), Expect = 1e-06
Identities = 63/273 (23%), Positives = 111/273 (40%), Gaps = 39/273 (14%)
Query: 40 KAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
K + N+TV + + A + + V V W+ +L + N+K+ + + T Y
Sbjct: 2711 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLES-NEKYAISVK-------GTIY 2762
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+ I+N + DE Y + ++R+H+ + KI++ D++ E ++ +
Sbjct: 2763 SLRIKNCAIVDESVY--GFRLGRLGASARLHV---ETVKIIKKPKDVTALENATVAFE-V 2816
Query: 159 ATGRPEPTVTWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECSASNDVA 208
+ V W H K+V D++ L +Q I+ +G+Y V
Sbjct: 2817 SVSHDTVPVKWFH---KSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTA-----VV 2868
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEAS--AVPSAEFQWYKDDKRLIEGK 266
+ + K+ V K VP + + +CE S VPS W K+ IE
Sbjct: 2869 GQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPS---MWLKNGVE-IEMS 2924
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASN 299
+ K+ + L +LI N S D YT V N
Sbjct: 2925 EKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNY-------PPYISEAKGTGVP 234
+D+ I G+ ++ A N+ RR +++ P E K
Sbjct: 30486 KDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTK 30545
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
+G+ L C+ P + +WY+ K LI+ +K K+ + L + D G YT
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRK-YKMSSDGRTHTLTVMTEEQEDEGVYT 30604
Query: 295 CVASNKLGHTNASIML 310
C+A+N++G S L
Sbjct: 30605 CIATNEVGEVETSSKL 30620
Score = 50.1 bits (118), Expect = 3e-06
Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
A V V++ V P +S K V G+ TL+C S PS WY++D + IE
Sbjct: 930 ARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ-IESSID 988
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
++ + +++L+ D G +TC A N+ G + S L
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYL 1030
Score = 50.1 bits (118), Expect = 3e-06
Identities = 64/276 (23%), Positives = 101/276 (36%), Gaps = 32/276 (11%)
Query: 31 VRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRST-ILYAGNDKWCLDPRVV 89
V+ F K +++ TV +G +A L C + +V W T IL + + D RV
Sbjct: 12280 VKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRV- 12338
Query: 90 LLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINE 149
+ I + D YTC + KTS +V + + +D+ + E
Sbjct: 12339 --------RKLVIHDCTPEDIKTYTCDAKDF---KTSCNLNVVPPHVEFLRPLTDLQVRE 12387
Query: 150 GNNISLTCIATGRPEPTVTW-----RHISPKAVGFVSED--EYLEIQGITREQSGDYECS 202
C R V W K +S+ L I + +Y C
Sbjct: 12388 KEMARFEC-ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCE 12446
Query: 203 ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQ--CEASAVPSAEFQWYKDDK 260
+ + +TV + + V + T++ CE S P AE WYK D+
Sbjct: 12447 VRTARTSGM-----LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYKGDE 12500
Query: 261 RLIE-GKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
+IE G+ + E R + L+ N D GNY C
Sbjct: 12501 EIIETGRYEILTEGRKRI--LVIQNAHLEDAGNYNC 12534
Score = 49.7 bits (117), Expect = 4e-06
Identities = 53/222 (23%), Positives = 88/222 (39%), Gaps = 24/222 (10%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D G YT + T V+ P++++ +++ G + +GRP+P ++
Sbjct: 3214 DAGEYTFVAGRNRSSVTLYVN--APEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3271
Query: 169 W-RHISPKAVGFVSE-----DEY-LEIQGITREQSGDYECSASND-----VAAPVVRRVK 216
W + + GF + EY L + E + Y C A ND +A + V
Sbjct: 3272 WYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVP 3331
Query: 217 VTVN-------YPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
V+ YPP I+ + T GQ QC S + WY DK+ I+ +
Sbjct: 3332 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKK-IKPSRF 3389
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
++ +L D G YT VASN +G +++ L
Sbjct: 3390 FRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3431
Score = 48.1 bits (113), Expect = 1e-05
Identities = 55/281 (19%), Positives = 109/281 (38%), Gaps = 37/281 (13%)
Query: 35 DATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNT 94
+A F K + N+ V + ++ L C + V W Y G+++ R +L+
Sbjct: 12462 EAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIW-------YKGDEEIIETGRYEILTEG 12514
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
+ + + IQN + D G Y C + + +VH +++ + + ++ I EG
Sbjct: 12515 RKRILV-IQNAHLEDAGNYNCRLPSSRTDGKVKVH---ELAAEFISKPQNLEILEGEKAE 12570
Query: 155 LTCIATGRPEPTVTWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECSAS 204
C + P V W+ S D+Y L ++ T + G Y
Sbjct: 12571 FVCSISKESFP-VQWKRDDKT---LESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVG 12626
Query: 205 NDVAA---PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKR 261
AA V+ ++++ V K T V Q+ CE + A+ +W+++++
Sbjct: 12627 AARAAAHLTVIEKLRIVV-------PLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEA 12678
Query: 262 LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ + K + + + + L + D NY +N G
Sbjct: 12679 IFDSSKYI-ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRG 12718
Score = 47.4 bits (111), Expect = 2e-05
Identities = 40/192 (20%), Positives = 73/192 (38%), Gaps = 13/192 (6%)
Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKA-----VGFVSEDEY 185
+P + + + EG+ + +G P P V+W + IS + F
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 186 LEIQGITREQSGDYECSASN---DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQ 242
L I +T+ SG Y A+N + VK P ++ + V G + LQ
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ +P+ ++Y+D I+ ++ L L+ D G Y+ A+N +G
Sbjct: 125 VRVTGIPTPVVKFYRDGAE-IQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 303 HTNASIMLFGPG 314
++ L G
Sbjct: 184 RATSTAELLVQG 195
Score = 45.1 bits (105), Expect = 9e-05
Identities = 71/313 (22%), Positives = 113/313 (36%), Gaps = 38/313 (12%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGND-KWCLDPRVVLLSNTQT 96
F + +++ TV + + A C + V W + G K+ D +
Sbjct: 12825 FVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSI-------- 12876
Query: 97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISL 155
+ + I++ + DE Y C V+ + SR L V+ P +I+ DI G ++
Sbjct: 12877 -HRLIIKDCRLDDECEYACGVED----RKSRARLFVEEIPVEIIRPPQDILEAPGADVVF 12931
Query: 156 TCIATGRPEPTVTWRHISPKAVG-----FVSEDEY--LEIQGITREQSGDYECSASNDVA 208
+ + V W + V +SE + L+I I G+Y A + A
Sbjct: 12932 LA-ELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEA 12990
Query: 209 APVVRRVKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 267
R K+ + P I A + V VG+ T+ A P AE +W+K+++ L
Sbjct: 12991 -----RAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTI 13045
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSNG 322
E F + D G Y V NK G I L GP EV+
Sbjct: 13046 DTTAEQTSFR----ILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTET 13101
Query: 323 TSRRAGCVWLLPL 335
W PL
Sbjct: 13102 FDGEVSLAWEEPL 13114
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 13/144 (9%)
Query: 33 SGDAT-FPKAMDNVTVRQGESATLRCTIDNR-VTRVAWLNRSTILYAGNDKWCLDPRVVL 90
SG+A K M +VT + GE+A L C I R + + W K + R
Sbjct: 30529 SGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG--------KELIQSRKYK 30580
Query: 91 LSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI---VEISSDISI 147
+S+ +++ + + DEG YTC + + L++Q +P+ +
Sbjct: 30581 MSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG 30640
Query: 148 NEGNNISLTCIATGRPEPTVTWRH 171
G+ + L + GRP P +TW H
Sbjct: 30641 AVGSTLRLHVMYIGRPVPAMTWFH 30664
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/185 (24%), Positives = 72/185 (38%), Gaps = 16/185 (8%)
Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGF----VSED---EYLE 187
+P I + D++ G L+C GRP P + W + + +S D L
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLT 30591
Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVN-----YPPYISEAKGTGVPVGQKGTLQ 242
+ +E G Y C A+N+V V K+ + +P Y + K G VG L
Sbjct: 30592 VMTEEQEDEGVYTCIATNEV-GEVETSSKLLLQATPQFHPGYPLKEKYYGA-VGSTLRLH 30649
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDY-GNYTCVASNKL 301
P W+ K L++ + + +EN + L+ NV + G Y SN
Sbjct: 30650 VMYIGRPVPAMTWFHGQK-LLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVF 30708
Query: 302 GHTNA 306
G +A
Sbjct: 30709 GTVDA 30713
Score = 43.1 bits (100), Expect = 4e-04
Identities = 59/276 (21%), Positives = 105/276 (38%), Gaps = 40/276 (14%)
Query: 40 KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS 99
K M N+ V + ++A+ C + + WL + ++K+ ++V+ +
Sbjct: 2886 KTMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEM-SEKF----KIVVQGKL---HQ 2937
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+ I N D YT D T V I+ I + DI+ E + I+
Sbjct: 2938 LIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIM-----ITSMLKDINAEEKDTITF---- 2988
Query: 160 TGRPEPTVTWRHISPK----AVGFVSEDEY----------LEIQGITREQSGDYECSASN 205
E TV + IS K V S D+ L I+ + + DY A
Sbjct: 2989 ----EVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGK 3044
Query: 206 DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+ + + + +I + K V ++ +CE S P QW KDD+ L +
Sbjct: 3045 ATSTATLYVEARHIEFRKHIKDIK---VLEKKRAMFECEVSE-PDITVQWMKDDQEL-QI 3099
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
+K++ ++ +L+ + D G YT VA +
Sbjct: 3100 TDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNV 3135
Score = 43.1 bits (100), Expect = 4e-04
Identities = 36/166 (21%), Positives = 72/166 (43%), Gaps = 16/166 (9%)
Query: 138 IVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKA-------VGFVSEDEYLEIQG 190
I +I + + + + + I PE ++W + K + + L ++
Sbjct: 8659 IKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKN 8718
Query: 191 ITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPS 250
+ G+Y V P + K+TV P + + + GQ T+ C+ S VP+
Sbjct: 8719 CQLKDQGNYRL-----VCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFS-VPN 8772
Query: 251 AEFQWYKDDKRLI-EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
+ +W+++ + L +G+ +VE++ + KL +V D G YTC
Sbjct: 8773 VKSEWFRNGRILKPQGRHKTEVEHK--VHKLTIADVRAEDQGQYTC 8816
Score = 43.1 bits (100), Expect = 4e-04
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 12/134 (8%)
Query: 207 VAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGK 266
+A V R+ ++V ++ GT V L P W KD L++
Sbjct: 19287 LAENVPPRIDLSVAMKSLLTVKAGTNV------CLDATVFGKPMPTVSWKKDGT-LLKPA 19339
Query: 267 KGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSN 321
+G+K+ + L L F+V+ D G+YT A N G +A+I L GP A +++
Sbjct: 19340 EGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINK 19399
Query: 322 GTSRRAGCVWLLPL 335
S RA W PL
Sbjct: 19400 MYSDRAMLSWEPPL 19413
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/227 (22%), Positives = 85/227 (37%), Gaps = 28/227 (12%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
F +++ TV++GE+AT C + + V W L+ R VL+S+
Sbjct: 11576 FMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTS--------RTVLISSEGKT 11627
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 157
+ +E++ V + D V+ + +V ++ P D + E + I+L C
Sbjct: 11628 HKLEMKEVTLDDISQIKAQVKELSSTAQLKV---LEADPYFTVKLHDKTAVEKDEITLKC 11684
Query: 158 IATGRPEPTVTW----RHISPKAVGFVSED---EYLEIQGITREQSGDYECSASND--VA 208
+ + V W I P + D L+I+ + G+Y C D A
Sbjct: 11685 EVS--KDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKA 11742
Query: 209 APVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQW 255
V + V P Y G V VG+ + E S P QW
Sbjct: 11743 NVTVEARLIKVEKPLY-----GVEVFVGETAHFEIELSE-PDVHGQW 11783
Score = 42.4 bits (98), Expect = 6e-04
Identities = 45/176 (25%), Positives = 74/176 (42%), Gaps = 30/176 (17%)
Query: 177 VGFVSEDEYLEIQGITREQSGDYE--------CSASNDVAAPVVRRVKVTVNYPPYISEA 228
V ++ED E + I + +G + +DV AP ++KV V + +
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAP---KIKVDVKFKDTVI-- 21472
Query: 229 KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEH 288
+ G+ L+ + S P +W KD K L EG ++++ F + L+ + +
Sbjct: 21473 ----LKAGEAFRLEADVSGRPPPTMEWSKDGKEL-EGTAKLEIKIADFSTNLVNKDSTRR 21527
Query: 289 DYGNYTCVASNKLGHT----NASIM-----LFGPGAVSEVSNGTSRRAGCVWLLPL 335
D G YT A+N G N ++ GP AV+EV TS + W PL
Sbjct: 21528 DSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEV---TSEKCVLSWFPPL 21580
Score = 41.6 bits (96), Expect = 0.001
Identities = 49/194 (25%), Positives = 74/194 (38%), Gaps = 33/194 (17%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIV-----QVSPKIVEISSDISINEGNNISLTCIATGRP 163
D G +T Q + V L V QV P VE +++I EG+ + + ATG P
Sbjct: 1524 DSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1583
Query: 164 EPTVTW--------RHISPK-AVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR- 213
P + W H PK + + L+I + S Y +A N R
Sbjct: 1584 NPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRC 1643
Query: 214 RVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--------FQWYKDDKRLIEG 265
+V V V + E K + +GT + + A P E QW + D L +
Sbjct: 1644 KVNVEVEFAEPEPERK----LIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGD--LYDK 1697
Query: 266 KKGVKVENRPFLSK 279
+K + +PF K
Sbjct: 1698 EK----QQKPFFKK 1707
Score = 40.8 bits (94), Expect = 0.002
Identities = 58/273 (21%), Positives = 108/273 (39%), Gaps = 36/273 (13%)
Query: 37 TFPKAMDNVTVRQGES-ATLRCTIDNRVTRVAWLNRSTILYAGNDKWCL--DPRVVLLSN 93
TF + + +V ++ ++ AT C +V W ++ G DK+ + D +V LS
Sbjct: 2175 TFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEG-DKYRMHSDRKVHFLS- 2232
Query: 94 TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
I +D D Y+C + D + KT+ ++ + V+ DI + E +
Sbjct: 2233 --------ILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSG 2284
Query: 154 SLTCIATGRPEPTV-TWRHISPKAVGFVSEDEY----------LEIQGITREQSGDYECS 202
L CI + PE W H V S +Y L ++ +T+E G+Y
Sbjct: 2285 ELECIVS--PENIEGKWYH---NDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFV 2339
Query: 203 ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEAS-AVPSAEFQWYKDDKR 261
++ + +S+ K V + +Q E ++ S E W KD +
Sbjct: 2340 IDGKKTTCKLKMKPRPIAILQGLSDQK-----VCEGDIVQLEVKVSLESVEGVWMKDGQE 2394
Query: 262 LIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
++ V + L+ ++++ D GNY+
Sbjct: 2395 -VQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS 2426
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/279 (19%), Positives = 110/279 (39%), Gaps = 25/279 (8%)
Query: 38 FPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
F K + ++ V + S L C + W + L + N K+ + R + +
Sbjct: 2269 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS-NGKYTITSR-------RGR 2320
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISLT 156
++ +++V D+G Y+ + K + L ++ P I++ SD + EG+ + L
Sbjct: 2321 QNLTVKDVTKEDQGEYSFVIDG----KKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLE 2376
Query: 157 CIATGRPEPTVTW----RHISPKA---VGFVSEDEYLEIQGITREQSGDYECSASNDVAA 209
+ W + + P + + L I+ +T+E +G+Y + A
Sbjct: 2377 -VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIP---AL 2432
Query: 210 PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
+ +V+V I+ K V G K L+C+ S +WY +D++ I+ V
Sbjct: 2433 GLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ-IKPDDRV 2491
Query: 270 KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
+ + +L+ D G Y + + N S+
Sbjct: 2492 QAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSV 2530
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/175 (21%), Positives = 69/175 (39%), Gaps = 32/175 (18%)
Query: 50 GESATLRCTIDNRVTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVY 108
G SA C + W+ + S I + ++ D + + I +V +
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGK---------DRKLHIIDVQLS 11183
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPK--IVEISSDISINEGNNISLTCIATGRPEPT 166
D G YTC ++ N KTS L+V+ P + + ++++ +G + L+C E
Sbjct: 11184 DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL--NKERD 11241
Query: 167 VTWR-----------HISPKAVGFV-------SEDEYLEIQGITREQSGDYECSA 203
V WR I P +G + ++D +T E + + ECS+
Sbjct: 11242 VVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSS 11296
Score = 40.4 bits (93), Expect = 0.002
Identities = 50/226 (22%), Positives = 84/226 (37%), Gaps = 33/226 (14%)
Query: 131 IVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG 190
I +S V +S +G + I R P W S V+E +++ I G
Sbjct: 26776 ITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKAS---FTNVTETQFI-ISG 26831
Query: 191 ITREQSGDYECSASN---------DVAAPVV-------RRVKVTVNYPPYISEAKGTGVP 234
+T+ ++ A N +V P+ + + + Y + GT V
Sbjct: 26832 LTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVK 26891
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
L+ S P+ +WYKDDK L + V VEN L+ ++ + + G Y
Sbjct: 26892 ------LRAGISGKPAPTIEWYKDDKEL-QTNALVCVENTTDLASILIKDADRLNSGCYE 26944
Query: 295 CVASNKLGHTNASIML------FGPGAVSEVSNGTSRRAGCVWLLP 334
N +G +A+I + PG E T+ + +W P
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPP 26990
Score = 40.0 bits (92), Expect = 0.003
Identities = 40/174 (22%), Positives = 69/174 (39%), Gaps = 15/174 (8%)
Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR------HISPKAVGFVSEDEYLE- 187
+PKI E ++ +G++ G+P+P W S + + ED E
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCEL 2136
Query: 188 -IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQK----GTLQ 242
I+ +T E S A N +A + V I+ + V ++ T +
Sbjct: 2137 VIRDVTAEDSASIMVKAIN-IAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2195
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCV 296
CE S P + +WYKD + EG K ++ + + L + D +Y+CV
Sbjct: 2196 CETSE-PFVKVKWYKDGMEVHEGDK-YRMHSDRKVHFLSILTIDTSDAEDYSCV 2247
Score = 40.0 bits (92), Expect = 0.003
Identities = 40/204 (19%), Positives = 73/204 (35%), Gaps = 15/204 (7%)
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG-- 178
+ P T + + +Q +P E ++++ +N +L C TG P+P V W + +
Sbjct: 30914 SEPITPKSDVPIQ-APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 30972
Query: 179 -------FVSEDEYLEIQGITREQSGDYECSASN-----DVAAPVVRRVKVTVNYPPYIS 226
F L I +T + + Y+ A+N A + V ++ P +
Sbjct: 30973 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 31032
Query: 227 EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVS 286
G+ +++ S P W K + + R F S + V
Sbjct: 31033 GMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVE 31092
Query: 287 EHDYGNYTCVASNKLGHTNASIML 310
D G Y A N+ G ++ L
Sbjct: 31093 RKDAGFYVVCAKNRFGIDQKTVEL 31116
Score = 40.0 bits (92), Expect = 0.003
Identities = 52/256 (20%), Positives = 83/256 (32%), Gaps = 47/256 (18%)
Query: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ------------VSPKIVEISSDISINE 149
++++ D+G Y C V D +S L V+ KI + + + E
Sbjct: 31628 VKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE 31687
Query: 150 ----------------GNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------- 185
G N+ T PEP VTW K ++ +Y
Sbjct: 31688 RPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGL 31747
Query: 186 --LEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNYPPYISEAK--------GTGVP 234
L I +T + +Y A N + ++ VT++ PP S +
Sbjct: 31748 YQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQ 31807
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
GQ + S +P +W KD + L G + L + D G Y
Sbjct: 31808 EGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYR 31867
Query: 295 CVASNKLGHTNASIML 310
A+N G T+ L
Sbjct: 31868 VTATNTAGSTSCQAHL 31883
Score = 39.7 bits (91), Expect = 0.004
Identities = 22/88 (25%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 133 QVSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQ 189
Q +P+I V++ + +++ G I L TG+PEP +TW KA + +D+ + I+
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITW----TKADMILKQDKRITIE 13740
Query: 190 GITREQSGDYECSASNDVAAPVVRRVKV 217
+ ++ + S +D ++ V V
Sbjct: 13741 NVPKKSTVTIVDSKRSDTGTYIIEAVNV 13768
Score = 39.7 bits (91), Expect = 0.004
Identities = 39/166 (23%), Positives = 70/166 (42%), Gaps = 10/166 (6%)
Query: 177 VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT-GVPV 235
V ++ED+ E + I + +G S +D P+ + +V + + + T V
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAG--AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNA 23639
Query: 236 GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
G+ L+ + P +W + DK + E + +++N F + LI + D G Y
Sbjct: 23640 GETFRLEADVHGKPLPTIEWLRGDKEIEESAR-CEIKNTDFKALLIVKDAIRIDGGQYIL 23698
Query: 296 VASNKLGHTNASI---MLFGPGAVS---EVSNGTSRRAGCVWLLPL 335
ASN G + + +L PG +V+ TS + W PL
Sbjct: 23699 RASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPL 23744
Score = 39.7 bits (91), Expect = 0.004
Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 205 NDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLI- 263
++++ P+ + V + P + E + V TL C+ + P +WY+ K +I
Sbjct: 30911 SEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA 30970
Query: 264 EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+G K E + +LI +V++ D Y A+N+ G + + L
Sbjct: 30971 DGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASL 31017
Score = 38.9 bits (89), Expect = 0.007
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 17/182 (9%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQ 95
TF + + +V V +G +AT I V V+W ++ V +S +
Sbjct: 7 TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPG------VQISFSD 60
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS---PKIVEISSDISINEGNN 152
+ + I V + G Y+ + TS L+V+ P V+ +++ +G+
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 153 ISLTCIATGRPEPTVTWRHISPK---AVGFVSEDE----YLEIQGITREQSGDYECSASN 205
+ L TG P P V + + ++ F E L I E SG Y +A+N
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 206 DV 207
V
Sbjct: 181 SV 182
Score = 38.9 bits (89), Expect = 0.007
Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 10/100 (10%)
Query: 116 SVQTDNHPKTSRVHLIVQVSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTWRH- 171
++ + P L V P+I V + S +++ G N+ L G+P PTV+W+
Sbjct: 19273 NISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKD 19332
Query: 172 --ISPKAVGFVSEDE----YLEIQGITREQSGDYECSASN 205
+ A G + LE+ + R+ SGDY +A N
Sbjct: 19333 GTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAEN 19372
Score = 38.1 bits (87), Expect = 0.012
Identities = 57/242 (23%), Positives = 95/242 (39%), Gaps = 37/242 (15%)
Query: 40 KAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS 99
+ + +VTV GE+AT C + V W Y K +VV S + ++
Sbjct: 12200 RPLKDVTVTAGETATFDCELSYEDIPVEW-------YLKGKKLEPSDKVVPRSEGKV-HT 12251
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNNISLTCI 158
+ +++V + D G VQ + +L V+ P + + D ++ EG L C
Sbjct: 12252 LTLRDVKLEDAG----EVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLEC- 12306
Query: 159 ATGRPEPTVTW-----RHISPKAVGFVSEDEY--LEIQGITREQSGDYECSASNDVAAPV 211
R V W + K V++ L I T E Y C A +
Sbjct: 12307 EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD------ 12360
Query: 212 VRRVKVTVN---YPPYISEAKG-TGVPVGQK--GTLQCEASAVPSAEFQWYKDDKRLIEG 265
K + N PP++ + T + V +K +CE S +A+ +W+KD + +G
Sbjct: 12361 ---FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGAEIKKG 12416
Query: 266 KK 267
KK
Sbjct: 12417 KK 12418
Score = 37.4 bits (85), Expect = 0.020
Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 8/98 (8%)
Query: 133 QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEY 185
Q+ P + + I+I G + + G+P PT W+ S AV
Sbjct: 18896 QLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 18955
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
L I+ +TR+ SG Y +A N + +++KV V P
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENS-SGTDTQKIKVVVMDAP 18992
Score = 37.4 bits (85), Expect = 0.020
Identities = 45/216 (20%), Positives = 72/216 (33%), Gaps = 52/216 (24%)
Query: 51 ESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDE 110
E A L C +++ V R + Y K + + Y ++I N+ D+
Sbjct: 32731 EIAKLTCVVESSVLRA----KEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQ 32786
Query: 111 GPYTCSVQTDN-----------------HPKTSRVHLI---------------------- 131
G Y C + + H K S++
Sbjct: 32787 GEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPE 32846
Query: 132 -VQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDE-- 184
+ P IV D +++ + ATG P PT W + I+ +SED+
Sbjct: 32847 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 32906
Query: 185 -YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
+LEI SG Y C+ N A V K+T+
Sbjct: 32907 FFLEIHKTDTSDSGLYTCTVKNS-AGSVSSSCKLTI 32941
Score = 36.6 bits (83), Expect = 0.034
Identities = 26/86 (30%), Positives = 36/86 (41%)
Query: 226 SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNV 285
S K + G T C+ S P + WYKD KR+ G++ + + L V
Sbjct: 1295 SRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVV 1354
Query: 286 SEHDYGNYTCVASNKLGHTNASIMLF 311
D G YT ASN G+ S L+
Sbjct: 1355 LPEDEGIYTAFASNIKGNAICSGKLY 1380
Score = 36.6 bits (83), Expect = 0.034
Identities = 27/95 (28%), Positives = 38/95 (40%), Gaps = 6/95 (6%)
Query: 145 ISINEGNNISLTCIATGRPEPTVTWRHIS------PKAVGFVSEDEYLEIQGITREQSGD 198
+ + G I L I GRP P VTWR + V V +L I TR+ SG
Sbjct: 18616 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGK 18675
Query: 199 YECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGV 233
Y + N V ++ P +S+ K + V
Sbjct: 18676 YSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDV 18710
Score = 36.2 bits (82), Expect = 0.044
Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 6/110 (5%)
Query: 230 GTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHD 289
G V G K L + P + W K D L + K+ + +EN P S + + D
Sbjct: 13699 GLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR-ITIENVPKKSTVTIVDSKRSD 13757
Query: 290 YGNYTCVASNKLGHTNASIMLF-----GPGAVSEVSNGTSRRAGCVWLLP 334
G Y A N G A + + GP A ++++ T+ W P
Sbjct: 13758 TGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPP 13807
Score = 36.2 bits (82), Expect = 0.044
Identities = 28/108 (25%), Positives = 43/108 (39%), Gaps = 6/108 (5%)
Query: 233 VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGN 292
V VGQ + P + W K+ K L+ K+ +++ P + +L D+G
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV-ELQIKEAVRADHGK 17978
Query: 293 YTCVASNKLGHTNASIMLF-----GPGAVSEVSNGTSRRAGCVWLLPL 335
Y A N GH S ++ GP +V+N T W PL
Sbjct: 17979 YIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPL 18026
Score = 36.2 bits (82), Expect = 0.044
Identities = 23/88 (26%), Positives = 34/88 (38%), Gaps = 7/88 (7%)
Query: 139 VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-------AVGFVSEDEYLEIQGI 191
V + + + G ++ + GRP PTVTWR ++ L I +
Sbjct: 27275 VALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQV 27334
Query: 192 TREQSGDYECSASNDVAAPVVRRVKVTV 219
TR +G Y + N V P V V V
Sbjct: 27335 TRNDTGKYILTIENGVGEPKSSTVSVKV 27362
Score = 34.7 bits (78), Expect = 0.13
Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 4/97 (4%)
Query: 236 GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
G+K ++ AVP W+KD K ++ + ++N + L D G YT
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKE-VKASDRLTMKNDHISAHLEVPKSVRADAGIYTI 14459
Query: 296 VASNKLGHTNASI---MLFGPGAVSEVSNGTSRRAGC 329
NKLG ASI ++ PG ++ ++ C
Sbjct: 14460 TLENKLGSATASINVKVIGLPGPCKDIKASDITKSSC 14496
Score = 33.5 bits (75), Expect = 0.28
Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 9/87 (10%)
Query: 141 ISSDISINEGNNISLTCIAT-GRPEPTVTW----RHISPKAVGFVSE---DEYLEIQGIT 192
I ++I G+ I L I+ G+P P +W + I P + ++ L I+ T
Sbjct: 20384 IKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYAT 20443
Query: 193 REQSGDYECSASNDVAAPVVRRVKVTV 219
R+ +G+Y +A+N V VKVTV
Sbjct: 20444 RKDAGEYTITATNPFGTK-VEHVKVTV 20469
Score = 33.5 bits (75), Expect = 0.28
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 6/92 (6%)
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG----HT 304
P + W K K I ++ + P S L + D G YT A+N G H
Sbjct: 20407 PLPKSSWSKAGKD-IRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHV 20465
Query: 305 NASIM-LFGPGAVSEVSNGTSRRAGCVWLLPL 335
+++ + GP E+SN ++ +A W PL
Sbjct: 20466 KVTVLDVPGPPGPVEISNVSAEKATLTWTPPL 20497
Score = 33.5 bits (75), Expect = 0.28
Identities = 24/96 (25%), Positives = 40/96 (41%), Gaps = 2/96 (2%)
Query: 211 VVRRVKVTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 269
V+ + T+++ P I+ + VP GQ + P+AE +WY + L E K +
Sbjct: 32362 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSK-I 32420
Query: 270 KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
N + L + D G Y V +N G +
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEAS 32456
Score = 33.1 bits (74), Expect = 0.37
Identities = 21/88 (23%), Positives = 38/88 (43%), Gaps = 11/88 (12%)
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS-------PKIVEISSDISI 147
+ Q+++E D+ + G Y V+ N S+ V P +++ + +
Sbjct: 16073 ELQFTVE----DLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV 16128
Query: 148 NEGNNISLTCIATGRPEPTVTWRHISPK 175
EG N+++ G P PT+TW PK
Sbjct: 16129 EEGTNVNIVAKIKGVPFPTLTWFKAPPK 16156
Score = 33.1 bits (74), Expect = 0.37
Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
Query: 150 GNNISLTCIATGRPEPTVTWRH-----ISPKAVGF--VSEDEYLEIQGITREQSGDYECS 202
G+NI + GRP+PTVTW+ + V F + L I R SG Y +
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 21139
Query: 203 ASNDV 207
A N V
Sbjct: 21140 ARNIV 21144
Score = 33.1 bits (74), Expect = 0.37
Identities = 22/110 (20%), Positives = 50/110 (45%), Gaps = 10/110 (9%)
Query: 123 PKTSRVHLIVQ---VSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRH--ISPKAV 177
P++ V ++ + + P + S S+ G ++ + +GRP+PT+TW + K
Sbjct: 23214 PRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQT 23273
Query: 178 GFVSEDEYLEIQGIT-----REQSGDYECSASNDVAAPVVRRVKVTVNYP 222
++ + L++ ++ ++ G Y + +N V VT++ P
Sbjct: 23274 TRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 32.7 bits (73), Expect = 0.49
Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 22/121 (18%)
Query: 112 PYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR- 170
P +Q D P T ++ L V+ I + G + + TG P P + W
Sbjct: 15383 PLNVVIQDDEVPPTIKLRLSVR--------GDTIKVKAGEPVHIPADVTGLPMPKIEWSK 15434
Query: 171 ------------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
I+ + V L I RE G Y +ASN + + V R V V
Sbjct: 15435 NETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS-VFRNVHVE 15493
Query: 219 V 219
V
Sbjct: 15494 V 15494
Score = 32.3 bits (72), Expect = 0.63
Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 21/109 (19%)
Query: 115 CSVQTDN--HPKTSRVHLIVQ--VSPKIVEISSDIS----INEGNNISLTCIATGRPEPT 166
C++ ++ P T ++ Q + P +E+ +D+ + + L GRPEP
Sbjct: 25079 CAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 25138
Query: 167 VTWRHISPKAVGFVSEDEYLE---------IQGITREQSGDYECSASND 206
V W KA G +++ +E I +TR SG Y + N+
Sbjct: 25139 VKWE----KAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN 25183
Score = 32.3 bits (72), Expect = 0.63
Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 17/118 (14%)
Query: 97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD----ISINEGNN 152
+YS + V+V Y+ S+ + + + ++ +E++ D ++I G +
Sbjct: 29412 KYSFRVAAVNVKGMSEYSESI--------AEIEPVERIEIPDLELADDLKKTVTIRAGAS 29463
Query: 153 ISLTCIATGRPEPTVTWR----HISPKAVGFVSED-EYLEIQGITREQSGDYECSASN 205
+ L +GRP P +TW ++ +A+ +E L + + R +G Y A N
Sbjct: 29464 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 29521
Score = 31.6 bits (70), Expect = 1.1
Identities = 33/178 (18%), Positives = 70/178 (39%), Gaps = 23/178 (12%)
Query: 35 DATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYA-GNDKWCLDPRVVLLSN 93
+ + + + +VT+++G++ T+ C + W IL G K ++ +V
Sbjct: 8744 EPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEVEHKV----- 8798
Query: 94 TQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP-KIVEISSDISINEGNN 152
+ + I +V D+G YTC + + L ++ P + + +I ++E +
Sbjct: 8799 ----HKLTIADVRAEDQGQYTCKYE----DLETSAELRIEAEPIQFTKRIQNIVVSEHQS 8850
Query: 153 ISLTCIATGRPEPTVTW-----RHISPKAVGFVSED--EYLEIQGITREQSGDYECSA 203
+ C + VTW + F ++ Y+ I +T + G Y A
Sbjct: 8851 ATFEC-EVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIA 8907
Score = 31.6 bits (70), Expect = 1.1
Identities = 28/118 (23%), Positives = 43/118 (36%), Gaps = 19/118 (16%)
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE----ISSDISINEGNNI 153
Y + + V+ EGP +T V + P VE + I I G +
Sbjct: 15072 YKLRVSAVNAAGEGP---------PGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 15122
Query: 154 SLTCIATGRPEPTVTWRHISPK------AVGFVSEDEYLEIQGITREQSGDYECSASN 205
+ + TGRP PT W + + V L I+ R+ G Y +A+N
Sbjct: 15123 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATN 15180
Score = 31.6 bits (70), Expect = 1.1
Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 7/68 (10%)
Query: 145 ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQ--GITREQSG 197
I++ G I + GRPEP +TW + K V + + +E+Q R G
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 17977
Query: 198 DYECSASN 205
Y SA N
Sbjct: 17978 KYIISAKN 17985
Score = 31.6 bits (70), Expect = 1.1
Identities = 36/161 (22%), Positives = 65/161 (40%), Gaps = 9/161 (5%)
Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGT-GVPVGQKGT 240
ED+ E + I R +G++ S +D + + R ++ + K V G+
Sbjct: 24669 EDQRYEFRVIARNAAGNF--SEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFV 24726
Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
L+ + P + W KD K L E +++++ + L+ + D G Y SN
Sbjct: 24727 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 24786
Query: 301 LGHTNASI---MLFGPGAVS---EVSNGTSRRAGCVWLLPL 335
G + I +L PG +V+ T+ + W PL
Sbjct: 24787 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPL 24827
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/106 (23%), Positives = 45/106 (42%), Gaps = 15/106 (14%)
Query: 45 VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
VT+R G S L ++ R V ++ I A ++ T++ + +
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR---------AIIDTTESYSLLIVDK 29506
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP------KIVEISSD 144
V+ YD G YT + + K++ V + V +P K+ E+S D
Sbjct: 29507 VNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRD 29552
Score = 30.8 bits (68), Expect = 1.8
Identities = 39/201 (19%), Positives = 73/201 (36%), Gaps = 36/201 (17%)
Query: 14 LVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRST 73
L++ +RL FL P + +VT ++ ESA + + RV W
Sbjct: 11922 LIIEGIRLKFLTP---------------LKDVTAKEKESAVFTVELSHDNIRVKWFK--- 11963
Query: 74 ILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHL-IV 132
ND+ R V + + +SI +++ + D T ++ + +S L ++
Sbjct: 11964 -----NDQRLHTTRSVSMQDEGKTHSITFKDLSIDD----TSQIRVEAMGMSSEAKLTVL 12014
Query: 133 QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSED---EY 185
+ P D + E + + L C + + V W + I P + D
Sbjct: 12015 EGDPYFTGKLQDYTGVEKDEVILQC-EISKADAPVKWFKDGKEIKPSKNAVIKADGKKRM 12073
Query: 186 LEIQGITREQSGDYECSASND 206
L ++ + G Y C D
Sbjct: 12074 LILKKALKSDIGQYTCDCGTD 12094
Score = 30.8 bits (68), Expect = 1.8
Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)
Query: 135 SPKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
+PK++ + + + + G+ I+L +G P PT+TW
Sbjct: 14680 APKVI-LRTSLEVKRGDEIALDASISGSPYPTITW 14713
Score = 30.8 bits (68), Expect = 1.8
Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 6/78 (7%)
Query: 147 INEGNNISLTCIATGRPEPTVTWRHISPKA-----VGFVSEDEYLEIQGITREQSGDYEC 201
I G+ + L+ I G P P VTW+ A + LEI+ E G Y
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSL 17289
Query: 202 SASNDVAAPVVRRVKVTV 219
+ N + V VKV V
Sbjct: 17290 TVENPAGSKTV-SVKVLV 17306
Score = 30.8 bits (68), Expect = 1.8
Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKG-T 240
E++ E + T+ + G+ + + +V VK + P + + K +GV + G T
Sbjct: 18167 ENQIYEFRVQTKNEGGESDWVKTEEVV------VKEDLQKP--VLDLKLSGVLTVKAGDT 18218
Query: 241 LQCEASA--VPSAEFQWYKD-DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVA 297
++ EA P E W KD D + VK++ R SK D G Y A
Sbjct: 18219 IRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTA 18278
Query: 298 SNKLG 302
+N G
Sbjct: 18279 TNTAG 18283
Score = 30.8 bits (68), Expect = 1.8
Identities = 30/124 (24%), Positives = 51/124 (41%), Gaps = 17/124 (13%)
Query: 136 PKIVEISSD----ISINEGNNISLTCIATGRPEPTVTW--------RHISPKAVGFVSED 183
P IVE + + I G ++ + + GRP P VTW + ++ + +
Sbjct: 27955 PPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST 28014
Query: 184 EYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP--YISEAKGTGVPVGQKGTL 241
L ++ TR+ G Y A N + +KV V P + + T + G+K TL
Sbjct: 28015 S-LFVRDATRDHRGVYTVEAKN-ASGSAKAEIKVKVQDTPGKVVGPIRFTNI-TGEKMTL 28071
Query: 242 QCEA 245
+A
Sbjct: 28072 WWDA 28075
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/70 (24%), Positives = 27/70 (38%), Gaps = 1/70 (1%)
Query: 233 VPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGN 292
+ VG+ L S P + W+KD+ ++E + ++ P L D G
Sbjct: 16830 IRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDR-THIKTTPATLALEKIKAKRSDSGK 16888
Query: 293 YTCVASNKLG 302
Y V N G
Sbjct: 16889 YCVVVENSTG 16898
Score = 29.6 bits (65), Expect = 4.1
Identities = 22/93 (23%), Positives = 37/93 (39%), Gaps = 8/93 (8%)
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
P+ E +W K D + + ++ + L+ NV+ +D G YT N G +A +
Sbjct: 22970 PTPEVKWGKVDGEI---RDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFV 23026
Query: 309 MLF-----GPGAVSEVSNGTSRRAGCVWLLPLL 336
+ P +V+ T W PLL
Sbjct: 23027 TVRVLDTPSPPVNLKVTEITKDSVSITWEPPLL 23059
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 6/61 (9%)
Query: 90 LLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSP------KIVEISS 143
++ T + S+ + NV+ YD G YT +++ + K++ V + V +P K+ EI+
Sbjct: 22988 IIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITK 23047
Query: 144 D 144
D
Sbjct: 23048 D 23048
Score = 29.6 bits (65), Expect = 4.1
Identities = 41/187 (21%), Positives = 69/187 (36%), Gaps = 25/187 (13%)
Query: 38 FPKAMDNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAG-NDKWCLDPRVVLLSNTQ 95
F + N T GE+ TI + V W + G NDK + +
Sbjct: 31692 FTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK------KYTFESDK 31745
Query: 96 TQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE---------ISSDIS 146
Y + I +V D+ YT + + + L V + P + + ++
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805
Query: 147 INEGNNISLTCIATGRPEPTVTW-RHISPKAVGFVSE------DEY-LEIQGITREQSGD 198
EG ++ +G P PT+ W + P ++G E D Y L I+ E +G
Sbjct: 31806 CQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGY 31865
Query: 199 YECSASN 205
Y +A+N
Sbjct: 31866 YRVTATN 31872
Score = 29.3 bits (64), Expect = 5.4
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 14/112 (12%)
Query: 24 LVPTGVPVRSGDATFPKAMDN-VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKW 82
LV +PVR F K ++ VTV +G+ L C + N+ V W I+ +
Sbjct: 11205 LVVEELPVR-----FVKTLEEEVTVVKGQPLYLSCEL-NKERDVVWRKDGKIVVEKPGR- 11257
Query: 83 CLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQV 134
+ P V+ L T I + D D G YT +V+ N+ + S +V+V
Sbjct: 11258 -IVPGVIGLMRALT-----INDADDTDAGTYTVTVENANNLECSSCVKVVEV 11303
Score = 29.3 bits (64), Expect = 5.4
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 5/109 (4%)
Query: 225 ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFN 284
+S G + G+ + + P W K++ L K V ++N S+LI +
Sbjct: 15108 VSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGEL--DKDRVVIDNVGTKSELIIKD 15165
Query: 285 VSEHDYGNYTCVASNKLG--HTNASIMLFG-PGAVSEVSNGTSRRAGCV 330
D+G Y A+N G A + +F PG V ++ + R C+
Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 15214
Score = 29.3 bits (64), Expect = 5.4
Identities = 23/93 (24%), Positives = 36/93 (38%), Gaps = 8/93 (8%)
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
P+ E +W +D ++ +E+ + LI NV+ D G Y N G +A +
Sbjct: 21888 PAPEVKWARDHGESLDK---ASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944
Query: 309 MLF-----GPGAVSEVSNGTSRRAGCVWLLPLL 336
+ GP +V T W PLL
Sbjct: 21945 NVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLL 21977
Score = 29.3 bits (64), Expect = 5.4
Identities = 18/72 (25%), Positives = 29/72 (40%), Gaps = 5/72 (6%)
Query: 139 VEISSDISINEGNNISLTCIATGRPEPTVTWRHISPK-----AVGFVSEDEYLEIQGITR 193
+E+ I+I G ++ L GRP P V W + + + S L + + R
Sbjct: 22946 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNR 23005
Query: 194 EQSGDYECSASN 205
SG Y + N
Sbjct: 23006 YDSGKYTLTLEN 23017
Score = 28.9 bits (63), Expect = 7.0
Identities = 12/34 (35%), Positives = 15/34 (44%)
Query: 136 PKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169
P IV + + EG C TG P+P V W
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNW 1874
Score = 28.9 bits (63), Expect = 7.0
Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 8/81 (9%)
Query: 134 VSPKI---VEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEY 185
VSP + + I ++ G I + +G+P PTVTW R + +A + +
Sbjct: 16520 VSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS 16579
Query: 186 LEIQGITREQSGDYECSASND 206
+ I+ R G Y A N+
Sbjct: 16580 MVIKNCQRSHQGVYSLLAKNE 16600
Score = 28.9 bits (63), Expect = 7.0
Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 13/97 (13%)
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASI 308
P W KD+K L + +EN S L V+ +D G Y N +G +S
Sbjct: 27299 PPPTVTWRKDEKNLGSDAR-YSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357
Query: 309 ----MLFGPGA-----VSEVSNGTSRRAGCVWLLPLL 336
+L P A V VS GT +W PL+
Sbjct: 27358 VSVKVLDTPAACQKLQVKHVSRGT---VTLLWDPPLI 27391
Score = 28.9 bits (63), Expect = 7.0
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 10/95 (10%)
Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRH--ISPKAVGFV--SEDE---YLEIQGITREQ 195
+ +++ G+N+ L G+P+P+++W + K FV S+ E L I+ +E
Sbjct: 27571 AQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEH 27630
Query: 196 SGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKG 230
G Y N V V +T+ P S+ KG
Sbjct: 27631 GGKYTVILDNAVCRIAVPITVITLGPP---SKPKG 27662
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/290 (28%), Positives = 111/290 (38%), Gaps = 24/290 (8%)
Query: 28 GVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDP 86
G P R TF N V GES TL C+ R++W +DP
Sbjct: 337 GSPARP---TFVIQPQNTEVLVGESVTLECSATGHPPPRISWTR------GDRTPLPVDP 387
Query: 87 RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS 146
RV N + IQNV D G Y CS + + +IVQ P+ D
Sbjct: 388 RV----NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRV 443
Query: 147 INEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECS 202
+ EG + C A G P P + W +S V L I G+ G YEC
Sbjct: 444 VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQ 503
Query: 203 ASNDVAA-PVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
A N + + VV + V P + S T V VG L C + P W KD
Sbjct: 504 AVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563
Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
++ E K + FL+ +V D G Y CVA N +G + S++L
Sbjct: 564 QVTESGK-FHISPEGFLT---INDVGPADAGRYECVARNTIGSASVSMVL 609
Score = 75.5 bits (184), Expect = 7e-14
Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 17/187 (9%)
Query: 136 PKIVEISSDISINEGNNISLTCIATGRPEPTVTW----RHISPKAVGFVS--EDEYLEIQ 189
P+I D + GN + TC A G P+P + W +S K ++ +D L IQ
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 190 GITREQSGDYECSASNDVAAPVVRRVKVTVNY------PPYISEAKGTGVPVGQKGTLQC 243
G Y+C A N A V+ +VT+ Y P ++ + + T V VG+ TL+C
Sbjct: 306 NTQETDQGIYQCMAKN--VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGH 303
A+ P W + D+ + V + L NV + D G Y C A+N +
Sbjct: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPS---GGLYIQNVVQGDSGEYACSATNNIDS 420
Query: 304 TNASIML 310
+A+ +
Sbjct: 421 VHATAFI 427
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 91.3 bits (225), Expect = 1e-18
Identities = 76/274 (27%), Positives = 124/274 (45%), Gaps = 28/274 (10%)
Query: 49 QGESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDV 107
Q ++ LRCT++ N R W S L D +D L + +T+ ++++N+
Sbjct: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNG-VDIYEPLYTQGETKV-LKLKNLRP 206
Query: 108 YDEGPYTCSVQTDN----HPKTSRVHLIVQVSPKIVEISSD--ISINEGNNISLTCIATG 161
D YTC V N K L +P +++S + + +N G N+++ C+ TG
Sbjct: 207 QDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTG 266
Query: 162 R-PEPTVTWRH-ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTV 219
P P + W H P +G +++ L I + SG Y C+A+N+V P + V + V
Sbjct: 267 GDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV 326
Query: 220 N---------YPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQWYKDDKRLIEGKKG 268
P I E++ + +GQ L C AVP + +QW+K+ K K+
Sbjct: 327 RSMKNATFQITPDVIKESE--NIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRL 384
Query: 269 VKVENRPFL----SKLIFFNVSEHDYGNYTCVAS 298
+ N P L S L ++ DYG Y C+AS
Sbjct: 385 LVTRNDPELPAVTSSLELIDLHFSDYGTYLCMAS 418
Score = 67.8 bits (164), Expect = 1e-11
Identities = 50/172 (29%), Positives = 74/172 (43%), Gaps = 22/172 (12%)
Query: 146 SINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSE----DEYLEIQGITREQSGDYEC 201
+I EG+ + L C+ TG P P V W + A E +E L I+ I R Q G Y C
Sbjct: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
Query: 202 SASNDVAAPVVRRVKVTVNY--------PPYISEAKGTGVPVGQKGT--LQCEASAVPSA 251
A N V P ++ ++V V Y +S+ +G Q+ T L+C ++ P A
Sbjct: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGN---FYQEKTVFLRCTVNSNPPA 165
Query: 252 EFQWYKDDKRLIEGK-KGVKVENRPF----LSKLIFFNVSEHDYGNYTCVAS 298
F W + L + GV + + L N+ DY +YTC S
Sbjct: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS 217
Score = 61.2 bits (147), Expect = 1e-09
Identities = 77/319 (24%), Positives = 127/319 (39%), Gaps = 60/319 (18%)
Query: 17 VSLRLLFLVPT-GVPVRSGDATFPKAM-----DNVTVRQGESATLRCTIDNRVTRVAWLN 70
VS+R + +P + R + T P A+ + + V GE+ T++C
Sbjct: 216 VSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQC------------- 262
Query: 71 RSTILYAGND-----KWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD-NHPK 124
L G D +W P + L ++ I +V D G Y C+ + +P
Sbjct: 263 ----LLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPA 318
Query: 125 TSRVHLIV--------QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWR------ 170
V+L+V Q++P +++ S +I + G ++ L+C P+ VT++
Sbjct: 319 KKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGK 376
Query: 171 --HISPKAVGFVSEDEY------LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-- 220
+S + + ++ E LE+ + G Y C AS A V+V ++
Sbjct: 377 PARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSE 436
Query: 221 -YPPYISEAKGTGVPVGQKGT---LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
PP IS KG V ++G+ LQCE P W + DK G+ +E P
Sbjct: 437 TVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPD 496
Query: 277 LSKLIFFNVSEHDYGNYTC 295
KL VS G Y C
Sbjct: 497 -GKLRLERVSRDMSGTYRC 514
Score = 58.9 bits (141), Expect = 6e-09
Identities = 54/188 (28%), Positives = 80/188 (42%), Gaps = 26/188 (13%)
Query: 39 PKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWC-LDPRVVLLSNTQTQ 97
PK VTVR+G A L+C + + R +L++ DK L P + L T
Sbjct: 445 PKGRAVVTVREGSPAELQCEVRGKP-------RPPVLWSRVDKEAALLPSGLPLEETPDG 497
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDN----HPKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
+ ++ V G Y C N P+ ++V L VQ P++ S D+ G +
Sbjct: 498 -KLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPV 556
Query: 154 SLTC-IATGRPE--PTVTWRH---------ISPKAVGFVSEDEYLEIQGITREQSGDYEC 201
L C + G P+ + WR + P A E L + +TR+ SG YEC
Sbjct: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYEC 615
Query: 202 SASNDVAA 209
S SNDV +
Sbjct: 616 SVSNDVGS 623
Score = 28.5 bits (62), Expect = 9.2
Identities = 60/306 (19%), Positives = 104/306 (33%), Gaps = 52/306 (16%)
Query: 31 VRSGDATFPKAMDNV-----TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCL 84
V +G A K DN+ T+R+G++ L+C + +V W + + +DK+
Sbjct: 30 VHAGQACVVKE-DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAG---SASDKF-- 83
Query: 85 DPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD-NHPKTSRVHLIVQ-VSPKIVEIS 142
+ ++ I+ + G Y C + P + + VQ + ++ +
Sbjct: 84 ------QETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVH 137
Query: 143 SDISINEGN-----NISLTCIATGRPEPTVTWR-------HISPKAVGFVS------EDE 184
+S GN + L C P W+ H V E +
Sbjct: 138 QTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETK 197
Query: 185 YLEIQGITREQSGDYECSAS--NDVAAP----VVRRVKVTVNYPPYISEAKGTGVPVGQK 238
L+++ + + Y C S N P R T +S + V G+
Sbjct: 198 VLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGEN 257
Query: 239 GTLQCEASAV-PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVA 297
T+QC + P + QW L G L +V D G Y C A
Sbjct: 258 VTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQG-------GTLSIPSVQARDSGYYNCTA 310
Query: 298 SNKLGH 303
+N +G+
Sbjct: 311 TNNVGN 316
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 90.1 bits (222), Expect = 3e-18
Identities = 73/270 (27%), Positives = 114/270 (42%), Gaps = 29/270 (10%)
Query: 50 GESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVY 108
G+ TL C N V R+ W L + +W T + +++I +V
Sbjct: 254 GQQVTLECFAFGNPVPRIKWRKVDGSL---SPQW-----------TTAEPTLQIPSVSFE 299
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
DEG Y C + T + +IVQ P+ +++ SD + G+N+ C A G+P PTV
Sbjct: 300 DEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVR 359
Query: 169 W-RHISPKA----VGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV-RRVKVTVNYP 222
W R+ P A V ++ D L ++ E SG Y+C A N + V P
Sbjct: 360 WLRNGEPLASQNRVEVLAGD--LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAP 417
Query: 223 PYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
+ +P + G + C+ A P A W K + L+ + + L
Sbjct: 418 DFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPD----GTL 473
Query: 281 IFFNVSEHDYGNYTCVASNKLGHTNASIML 310
I N+S D G YTC A N +G N++ +L
Sbjct: 474 IIRNISRSDEGKYTCFAENFMGKANSTGIL 503
Score = 39.7 bits (91), Expect = 0.004
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Query: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATG 161
I+N+ DEG YTC + S L V+ + KI S IN G+N++L C A+
Sbjct: 475 IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASH 534
Query: 162 RP--EPTVTW 169
P + T TW
Sbjct: 535 DPTMDLTFTW 544
Score = 37.4 bits (85), Expect = 0.020
Identities = 37/169 (21%), Positives = 65/169 (38%), Gaps = 18/169 (10%)
Query: 153 ISLTCIATGRPEPTVTWR------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
+ L C A P T W+ + P + + + + + +G Y+C ASN
Sbjct: 57 VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
Query: 207 VAAPVVRRVKVTVNYPPYISEAKGTGVPV--GQKGTLQCEASA-VPSAEFQWYKDDKRLI 263
V V R + + S+ + V G L C A P ++W L
Sbjct: 117 VGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL-----LN 171
Query: 264 EGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNKLGHTNASI 308
E + + R F+S+ L + D GNY+C+A++ + + S+
Sbjct: 172 EFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSV 220
Score = 28.9 bits (63), Expect = 7.0
Identities = 23/68 (33%), Positives = 28/68 (41%), Gaps = 7/68 (10%)
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
VGQ+ TL+C A P +W K D L + E L +VS D G Y
Sbjct: 253 VGQQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAE-----PTLQIPSVSFEDEGTYE 305
Query: 295 CVASNKLG 302
C A N G
Sbjct: 306 CEAENSKG 313
>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
Length = 437
Score = 89.4 bits (220), Expect = 4e-18
Identities = 95/321 (29%), Positives = 145/321 (45%), Gaps = 32/321 (9%)
Query: 14 LVVVSLRLLFLVPTGVP---VRSGDATFPKAMDNVTVRQGESATLRCTID-NRVTRVAWL 69
+ V+ L L LVP V+ FP NVTV +G +A L C +D N T + W
Sbjct: 1 MFVLFLCNLSLVPAAASKNKVKGSQGQFPLTQ-NVTVVEGGTAILTCRVDQNDNTSLQWS 59
Query: 70 NRST-ILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRV 128
N + LY + K D R+ L+ + + SI + +V + DEG YTCS+ T KTS+
Sbjct: 60 NPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFT-MPVKTSKA 118
Query: 129 HLIVQVSPKIVEISSDIS-INEGNNISLTCIATG-RPEPTVTW--RHISPKAVGFVSEDE 184
+L V P+ +IS S + EG+ + LTC +G +P + W K V ++ E++
Sbjct: 119 YLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEED 178
Query: 185 YLEIQGITREQSGDYECSASND-------------VAAPVVRRVKVTVNYPPYISEAKGT 231
+ T + D+ S+D A P V + ++Y P + T
Sbjct: 179 -ANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPST 237
Query: 232 GVP-VGQKGTLQCEASAVPSAE-FQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHD 289
P GQ L CE+ P E W KD L + + V V R ++F N + D
Sbjct: 238 PFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMV-VSGREL--NILFLN--KTD 292
Query: 290 YGNYTCVASNKLGHTNASIML 310
G Y C A+N +G ++A +L
Sbjct: 293 NGTYRCEATNTIGQSSAEYVL 313
Score = 35.0 bits (79), Expect = 0.098
Identities = 33/126 (26%), Positives = 50/126 (39%), Gaps = 8/126 (6%)
Query: 105 VDVYDEG-PYTCSVQTDNHPKTSRVH---LIVQVSPKIVEISSDISINEGNNISLTCIAT 160
VD D+G C V ++ T +V L + +P + I S EG + LTC +
Sbjct: 194 VDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESK 253
Query: 161 GRPEPT-VTWRHIS---PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
G+P P V W P V L I + + +G Y C A+N + V
Sbjct: 254 GKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVL 313
Query: 217 VTVNYP 222
+ + P
Sbjct: 314 IVHDVP 319
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 89.0 bits (219), Expect = 6e-18
Identities = 64/268 (23%), Positives = 114/268 (42%), Gaps = 25/268 (9%)
Query: 44 NVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
+V G++ TL C + N V + W + L+P + + ++I
Sbjct: 250 DVYALMGQNVTLECFALGNPVPDIRW------------RKVLEPMPSTAEISTSGAVLKI 297
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
N+ + DEG Y C + + + VQ P+ VE +D ++ G+++ C+ATG+
Sbjct: 298 FNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGK 357
Query: 163 PEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNY 221
P PT+ W G+ L + +T E +G Y+C A N A +K+
Sbjct: 358 PIPTIRW-----LKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALA 412
Query: 222 PPYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
P + + + G ++C+ A P +F W K + L+ + + E+
Sbjct: 413 PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED----GS 468
Query: 280 LIFFNVSEHDYGNYTCVASNKLGHTNAS 307
L N++ +D G YTC A N G N++
Sbjct: 469 LEINNITRNDGGIYTCFAENNRGKANST 496
Score = 74.3 bits (181), Expect = 1e-13
Identities = 75/318 (23%), Positives = 126/318 (39%), Gaps = 50/318 (15%)
Query: 31 VRSGDATF---------PKAMDNVTVRQGESATLRCTIDNRVT---RVAWLNRSTILYAG 78
VRS +AT P+ V V++G+ L C WL ++
Sbjct: 123 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFIT 182
Query: 79 NDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKT--SRVHLIVQVSP 136
DK R V +QT ++ I NV+ D+G Y+C V + + K+ S+ ++ +
Sbjct: 183 MDK----RRFV----SQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 234
Query: 137 K--------IVEISSDISINEGNNISLTCIATGRPEPTVTWRHI---SPKAVGFVSEDEY 185
+ IV D+ G N++L C A G P P + WR + P +
Sbjct: 235 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAV 294
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-YPPYISEAKGTGVPVGQKGTLQCE 244
L+I I E G YEC A N + + ++ V +P ++ T V +G C
Sbjct: 295 LKIFNIQLEDEGIYECEAEN-IRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCV 353
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG-- 302
A+ P +W K+ +G +L ++V+ + G Y C+A N G
Sbjct: 354 ATGKPIPTIRWLKNGYAYHKG-------------ELRLYDVTFENAGMYQCIAENTYGAI 400
Query: 303 HTNASIMLFGPGAVSEVS 320
+ NA + + E++
Sbjct: 401 YANAELKILALAPTFEMN 418
Score = 56.2 bits (134), Expect = 4e-08
Identities = 58/244 (23%), Positives = 98/244 (40%), Gaps = 16/244 (6%)
Query: 86 PRVVLLSNTQTQYSIEIQNVDVYDE--GPYTCSVQTDNHPKTSRVHL-IVQVSP--KIVE 140
P + L N + E++ DV E G Y C + + L I+ ++P ++
Sbjct: 360 PTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 419
Query: 141 ISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG----FVSEDEYLEIQGITREQS 196
+ I +G + + C P+P +W + V + ED LEI ITR
Sbjct: 420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDG 479
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQ 254
G Y C A N+ V + I + VG+ T+QC AS P+ + F
Sbjct: 480 GIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFV 539
Query: 255 WYKDDKRLIEGKKGVKVENRPFL---SKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IM 309
W + + K+ + + L +L+ N G YTC A + +++AS ++
Sbjct: 540 WSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLV 599
Query: 310 LFGP 313
+ GP
Sbjct: 600 VRGP 603
Score = 35.4 bits (80), Expect = 0.075
Identities = 42/166 (25%), Positives = 67/166 (40%), Gaps = 30/166 (18%)
Query: 153 ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASN 205
+SL C A P P WR + ++ D Y + G ++ +G Y C ASN
Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDV--DLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASN 118
Query: 206 DVAAPVVRRVKVTVN------YPPYISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYK 257
+ +VR + T++ +PP E V G+ L C+ ++W
Sbjct: 119 NYG--MVRSTEATLSFGYLDPFPP--EERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWL- 173
Query: 258 DDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASN 299
L E + ++ R F+S+ L NV D GNY+C S+
Sbjct: 174 ----LNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 89.0 bits (219), Expect = 6e-18
Identities = 64/268 (23%), Positives = 114/268 (42%), Gaps = 25/268 (9%)
Query: 44 NVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
+V G++ TL C + N V + W + L+P + + ++I
Sbjct: 239 DVYALMGQNVTLECFALGNPVPDIRW------------RKVLEPMPSTAEISTSGAVLKI 286
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGR 162
N+ + DEG Y C + + + VQ P+ VE +D ++ G+++ C+ATG+
Sbjct: 287 FNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGK 346
Query: 163 PEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVKVTVNY 221
P PT+ W G+ L + +T E +G Y+C A N A +K+
Sbjct: 347 PIPTIRW-----LKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALA 401
Query: 222 PPYISEAKGTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK 279
P + + + G ++C+ A P +F W K + L+ + + E+
Sbjct: 402 PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED----GS 457
Query: 280 LIFFNVSEHDYGNYTCVASNKLGHTNAS 307
L N++ +D G YTC A N G N++
Sbjct: 458 LEINNITRNDGGIYTCFAENNRGKANST 485
Score = 74.3 bits (181), Expect = 1e-13
Identities = 75/318 (23%), Positives = 126/318 (39%), Gaps = 50/318 (15%)
Query: 31 VRSGDATF---------PKAMDNVTVRQGESATLRCTIDNRVT---RVAWLNRSTILYAG 78
VRS +AT P+ V V++G+ L C WL ++
Sbjct: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFIT 171
Query: 79 NDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKT--SRVHLIVQVSP 136
DK R V +QT ++ I NV+ D+G Y+C V + + K+ S+ ++ +
Sbjct: 172 MDK----RRFV----SQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 223
Query: 137 K--------IVEISSDISINEGNNISLTCIATGRPEPTVTWRHI---SPKAVGFVSEDEY 185
+ IV D+ G N++L C A G P P + WR + P +
Sbjct: 224 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAV 283
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN-YPPYISEAKGTGVPVGQKGTLQCE 244
L+I I E G YEC A N + + ++ V +P ++ T V +G C
Sbjct: 284 LKIFNIQLEDEGIYECEAEN-IRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCV 342
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG-- 302
A+ P +W K+ +G +L ++V+ + G Y C+A N G
Sbjct: 343 ATGKPIPTIRWLKNGYAYHKG-------------ELRLYDVTFENAGMYQCIAENTYGAI 389
Query: 303 HTNASIMLFGPGAVSEVS 320
+ NA + + E++
Sbjct: 390 YANAELKILALAPTFEMN 407
Score = 56.2 bits (134), Expect = 4e-08
Identities = 58/244 (23%), Positives = 98/244 (40%), Gaps = 16/244 (6%)
Query: 86 PRVVLLSNTQTQYSIEIQNVDVYDE--GPYTCSVQTDNHPKTSRVHL-IVQVSP--KIVE 140
P + L N + E++ DV E G Y C + + L I+ ++P ++
Sbjct: 349 PTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 408
Query: 141 ISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG----FVSEDEYLEIQGITREQS 196
+ I +G + + C P+P +W + V + ED LEI ITR
Sbjct: 409 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDG 468
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQ 254
G Y C A N+ V + I + VG+ T+QC AS P+ + F
Sbjct: 469 GIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFV 528
Query: 255 WYKDDKRLIEGKKGVKVENRPFL---SKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IM 309
W + + K+ + + L +L+ N G YTC A + +++AS ++
Sbjct: 529 WSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLV 588
Query: 310 LFGP 313
+ GP
Sbjct: 589 VRGP 592
Score = 35.4 bits (80), Expect = 0.075
Identities = 42/166 (25%), Positives = 67/166 (40%), Gaps = 30/166 (18%)
Query: 153 ISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASN 205
+SL C A P P WR + ++ D Y + G ++ +G Y C ASN
Sbjct: 50 VSLNCRARASPFPVYKWRMNNGDV--DLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASN 107
Query: 206 DVAAPVVRRVKVTVN------YPPYISEAKGTGVPVGQKGTLQCEA--SAVPSAEFQWYK 257
+ +VR + T++ +PP E V G+ L C+ ++W
Sbjct: 108 NYG--MVRSTEATLSFGYLDPFPP--EERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWL- 162
Query: 258 DDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASN 299
L E + ++ R F+S+ L NV D GNY+C S+
Sbjct: 163 ----LNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 87.4 bits (215), Expect = 2e-17
Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 43 DNVTVRQGESATLRCTI----DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
+ + +G + TL CT D+ ++ V W S ILY + + + R + +Y
Sbjct: 505 ETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFV--RYWQQAGEALEY 561
Query: 99 S--IEIQNVDVYDEGPYTCSVQTDNH---PKTSRVHLIVQVSPKIVEISSDISINEGNNI 153
+ + + NV+ DEG Y C V NH + + L V P ++ D++I G
Sbjct: 562 TSILHLFNVNFTDEGKYQCIVT--NHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMA 619
Query: 154 SLTCIATGRPEPTVTWRH--------ISPKAVGFVSEDEYLEIQGITREQSGDYECSASN 205
L C A G P P ++W+ + + + ED+ I + E G Y C A N
Sbjct: 620 RLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQN 679
Query: 206 DVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
+ P +I + V G+ LQC A P+ W KDD L+
Sbjct: 680 TAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL-- 737
Query: 266 KKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
V R F + LI + D G YTC+ SN LG I L
Sbjct: 738 -----VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYL 781
Score = 51.6 bits (122), Expect = 1e-06
Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 15/176 (8%)
Query: 37 TFPKAMDNVTVRQGESATLRCTIDNR-VTRVAWL-NRSTILYAGNDKWCLDPRVVLLSNT 94
+F K ++T+R G A L C + +++W + T A ++ R+ ++
Sbjct: 603 SFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARER-----RMHVMPED 657
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNIS 154
+ I NV + D G Y+C Q ++ L V +P + D ++ G
Sbjct: 658 DVFF---IANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAV 714
Query: 155 LTCIATGRPEPTVTW-RHISPKAVG----FVSEDEYLEIQGITREQSGDYECSASN 205
L CIA G P P + W + P V F + ++ L I E +G Y C SN
Sbjct: 715 LQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSN 770
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 85.5 bits (210), Expect = 6e-17
Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+ I + D G Y C + + L+VQV P I D+S EG++ L C A
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870
Query: 160 TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
G PEP +TW G + L ++ + + +G Y C+A N V RR
Sbjct: 2871 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 2929
Query: 215 VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V +T+ P + G + +G + L+C A P+ W +D+ + EG V
Sbjct: 2930 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 2984
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
+ S L VS D G Y C A N++G T A
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 3017
Score = 82.0 bits (201), Expect = 7e-16
Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
D V VR G+ A L C D A + Y L R L Q +EI
Sbjct: 1849 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 1899
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
Q V D+G Y+C V L VQV P ++ +S G+ + LTC +G
Sbjct: 1900 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 1959
Query: 162 RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
P PTVTW + AV G VS L++ + Q+G Y C A N A +
Sbjct: 1960 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 2018
Query: 217 VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V V P I A+ V GQ+ L CEA P + W KD L + G +
Sbjct: 2019 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 2077
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L+ + D G YTCVA N G
Sbjct: 2078 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 2106
Score = 80.9 bits (198), Expect = 2e-15
Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)
Query: 21 LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
LL L P PV GD + ++ VTV + +L+C + N V ++WL
Sbjct: 1645 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 1693
Query: 80 DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
+ PR+ +L + Q +++ +V D Y C + L VQV P+I
Sbjct: 1694 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1749
Query: 140 EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
+ + ++ +++SL C P P VTW S + V + L++
Sbjct: 1750 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1809
Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
SG Y C A N A + V+++V PP +A V VG K L CE A+
Sbjct: 1810 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1868
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
P WYKD + L+ ++ + +L D G Y+C SN G
Sbjct: 1869 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 1919
Score = 80.5 bits (197), Expect = 2e-15
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
++I+ VD+ DEG YTC+ V L V V P I + ++ E +++L C+A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 160 TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
+G P P V+W + +S VS D L I+ +G Y C ASN VA R
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 777
Query: 215 VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
+ VN PP I+ P V L C A+ PS W KD + G G++V
Sbjct: 778 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 837
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
P L + D G Y+CVA + +G ++L
Sbjct: 838 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 874
Score = 79.0 bits (193), Expect = 6e-15
Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)
Query: 45 VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ V G++A L C + ++ W L G D + P VLL Q S
Sbjct: 1264 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 1318
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
G Y+C KT L V ++P I+ E S+D +++ N ISL C
Sbjct: 1319 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 1373
Query: 159 ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
A P P +TW + + + + L+I +E +G Y C +N++ V+
Sbjct: 1374 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 1432
Query: 214 RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
V V PP IS+ K V TL+CE+ AVP +WYKD + +
Sbjct: 1433 NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 1492
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ ++V L ++ VS D G Y CVA+N G
Sbjct: 1493 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 1526
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
++EI G YTCS + V L VQ SP + + S + + L C
Sbjct: 2720 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 2779
Query: 159 ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
A+G P PT+TW+ +++ V L I + E +G+Y C A N A + +
Sbjct: 2780 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 2838
Query: 215 VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
++ V PP I G L C+A P W KD + + G +G K
Sbjct: 2839 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 2896
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+P +L+ N+ D G YTC A N +G + L
Sbjct: 2897 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2932
Score = 76.3 bits (186), Expect = 4e-14
Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)
Query: 48 RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
R GE T+ C + + V+WL L L R +L + T + I V
Sbjct: 2135 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 2184
Query: 107 VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
+ D G +TC + L VQV P + VE +D+ + G+ + L C A G P
Sbjct: 2185 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244
Query: 165 PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
P V+W + P + + L+++ + SG Y C A ++ A R ++TV PP
Sbjct: 2245 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 2303
Query: 224 YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
+I ++ + G L C+A P W+KD + L ++EN +++
Sbjct: 2304 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 2357
Query: 281 IFFNVSEHDYGNYTCVASNKLG 302
+ D G YTC+A + G
Sbjct: 2358 L----RVRDAGLYTCLAESPAG 2375
Score = 73.2 bits (178), Expect = 3e-13
Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)
Query: 42 MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+ N+T TL C + + W + G D + L +L TQTQ
Sbjct: 1168 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 1225
Query: 101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
D G Y+C + + V V P I ++ I + +G L C
Sbjct: 1226 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1277
Query: 159 ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
TG P+P +TW HISP V L++ +G Y C A+N
Sbjct: 1278 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 1330
Query: 207 VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
V + +++V P I S + V V +L CEA A PS W KD
Sbjct: 1331 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
E + +++ P L N + D G YTCV +N+LG N + + P ++S+
Sbjct: 1390 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1446
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)
Query: 82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
W D +L + + S++++ V D G Y+C ++ L V P I +
Sbjct: 2249 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308
Query: 142 S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
+++S+ G + L C A G P+P +TW H +A+ + E+ + + +G Y
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 2366
Query: 200 ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
C A + A + + +V V PP I +G G+ GQ L+C A P+ + W
Sbjct: 2367 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 2424
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
++D L E E FL +S D G+Y+C A N G T+ + +
Sbjct: 2425 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2481
Query: 311 ----FGPGAVSEVSNGTS 324
GP AV+ N T+
Sbjct: 2482 PTIRSGPPAVNVSVNQTA 2499
Score = 72.0 bits (175), Expect = 7e-13
Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D + C V + + V V P I + +D ++ + LTC +TG P PTV+
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698
Query: 169 W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W + + G+ VS LEI +G Y CSA N A + V +TV P
Sbjct: 2699 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 2757
Query: 224 YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
+ V ++ L CEAS +P W K+ + GV + P +L
Sbjct: 2758 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 2813
Query: 283 FNVSEHDYGNYTCVASNKLG 302
+ S D GNY C+A N G
Sbjct: 2814 AHASPEDAGNYLCIAKNSAG 2833
Score = 71.6 bits (174), Expect = 9e-13
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
EG YTC + + L V V P+I E + +S+ + +L C ATG+P PT
Sbjct: 1039 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1098
Query: 167 VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
VTW + VG ++ + L ++ +G Y C A N +A R+ +++V
Sbjct: 1099 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 1156
Query: 221 YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
PP + + TL CEA +P +W++ ++ + G+ +
Sbjct: 1157 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1216
Query: 277 LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
L E D G Y+C+ASN+ G N S+ + P ++
Sbjct: 1217 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1255
Score = 70.1 bits (170), Expect = 3e-12
Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 79 NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
N W D +L ++T+ Y+ +++ D G YTC L V
Sbjct: 342 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 400
Query: 134 VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
V P I + G ++L C+A G P PT++W H ++
Sbjct: 401 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 460
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
L ++ SG Y C AS+ A V + V V PP + A+G G VGQ L
Sbjct: 461 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 519
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
C+AS P QW ++ R E GV+V ++ + L +V G + C A+N+ G
Sbjct: 520 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 576
Query: 303 HTNASI 308
A +
Sbjct: 577 TAGAEV 582
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 16/223 (7%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
+++ DV+D G YTC +L V V+P + S +++ EG+ SL+C
Sbjct: 935 LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCE 994
Query: 159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
G P P ++WR G + +++ G Q G Y C SN V
Sbjct: 995 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 1053
Query: 212 VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ +++ V+ PP I+ + T V V Q G TL+C A+ P W +D + + +
Sbjct: 1054 SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 1112
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G++++N+ L G Y+CVA N G L
Sbjct: 1113 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1153
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
++I V + G Y+C + L+V P I+ E+ ++++N + +SL
Sbjct: 1615 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1674
Query: 156 TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
C A G P PT++W SP V ED + L++ + Y C A N A
Sbjct: 1675 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 1733
Query: 211 VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + V PP I+ + + + +L C+ A P+ E WYKD + L G
Sbjct: 1734 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 1790
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+V P L D G YTC A N G + L
Sbjct: 1791 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1832
Score = 66.2 bits (160), Expect = 4e-11
Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)
Query: 88 VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
+VL + TQ+ +++Q + D G Y+C+ + + + + P I
Sbjct: 2429 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 2488
Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
++++ L C A G P P V+WR + P++ F + + L IQ + + +G
Sbjct: 2489 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2548
Query: 198 DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
Y C ASN + R + P + L CEAS P W+K
Sbjct: 2549 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 2608
Query: 258 D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
D D RL +G + N L+ D + CV SN++G +
Sbjct: 2609 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 2655
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 37/238 (15%)
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS-------SDISINEG 150
+ ++I N D G YTC V + H+ V + P I + ++
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463
Query: 151 NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
+ ++L C + P PT+ W + ++P + + + E L+IQ SG Y C A+N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 206 DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
VA + V + PP EA+G + L C+
Sbjct: 1524 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+A+P + WY++D+ L G + ++ L + V + G Y+C ASN++G
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 1637
Score = 63.5 bits (153), Expect = 3e-10
Identities = 43/114 (37%), Positives = 57/114 (50%), Gaps = 16/114 (14%)
Query: 157 CIATGRPEPTVTWR--------HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVA 208
C G P+P VTWR H P V E+ L + ++ SGDYEC A+N+V
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVA--VLEEGSLFLASVSPADSGDYECQATNEVG 81
Query: 209 APVVRRVKVTVNYPPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQWYKD 258
+ RR K+ V PP I E A +G+ GQ TL+C+A+ P E W KD
Sbjct: 82 S-TSRRAKLVVYVPPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIVWLKD 133
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/210 (23%), Positives = 92/210 (43%), Gaps = 11/210 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D G Y+C + V L V + P I+ ++S+ +++L C + P P ++
Sbjct: 853 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 912
Query: 169 W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W R + P+ +S D+ L++ +G Y C A N A + + V P
Sbjct: 913 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGRSEKHYNLNVWVAP 971
Query: 224 Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
+ E+ V G +L CE VP + W KD + L +G +++ + +L+
Sbjct: 972 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 1029
Query: 282 FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
+ ++ G YTC SN +G+++ + L
Sbjct: 1030 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059
Score = 60.8 bits (146), Expect = 2e-09
Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)
Query: 81 KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
+W D + VL Q + I V DEG Y C + + L V
Sbjct: 250 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 309
Query: 136 PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
P I + ++++ E + + L C A G P P +TW S K V + L+
Sbjct: 310 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 368
Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
+ +G Y C ASN V A + ++ V PP I A G V G+ L+C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 427
Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
A PS W+ + + E + ++E S L + E G Y+CVAS+ G
Sbjct: 428 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 483
Score = 60.5 bits (145), Expect = 2e-09
Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)
Query: 25 VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
VPT +RSG P A+ NV+V Q +A L C D V+W D+
Sbjct: 2481 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 2521
Query: 84 LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
LDPR + S+ IQ V D G Y C L V P I S
Sbjct: 2522 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2580
Query: 144 DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
++++ L C A+G P+P V W K + + Y L + + S
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 2640
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
+EC SN+V R +VTV+ PP I++ + V + L C ++ +P+ W
Sbjct: 2641 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2699
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K +L G +G P + I + H G YTC A N G + + L
Sbjct: 2700 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 2751
Score = 59.3 bits (142), Expect = 5e-09
Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 24/272 (8%)
Query: 46 TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
++R G+ LRC T R+ W ND+ P +S +++
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 2995
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
V D G Y C + + +T V + V+ +P + E S + G +I L C+ G
Sbjct: 2996 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 3054
Query: 163 PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P + W + + ++ L I R+ +G Y+C A N++ + V
Sbjct: 3055 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 3114
Query: 219 VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
+ P + E + V G L+C+A+ P+ +W + + L ++ + +
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 3170
Query: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L NV D G Y CVA N LG A L
Sbjct: 3171 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 3202
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/162 (32%), Positives = 69/162 (42%), Gaps = 13/162 (8%)
Query: 150 GNNISLTCIATGRPEPTVTW-RHISPKAVG----FVSED-EYLEIQGITREQSGDYECSA 203
G ++ L C +G P P V W + P G V ED + L I G G Y+C A
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 204 SNDVAAPVVRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQ--CEASAVPSAEFQWYKDDK 260
+ A R ++ V+ PP I + TG V V + +Q CEA VP+ W+KD
Sbjct: 292 FSP-AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 350
Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L K V +L D G YTC ASN +G
Sbjct: 351 LLPTSTKVVYTRGG---RQLQLGRAQSSDAGVYTCKASNAVG 389
Score = 53.5 bits (127), Expect = 3e-07
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 5/144 (3%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+ I + D G Y C + + V L++Q +P D+++ G++++L C
Sbjct: 3081 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3140
Query: 159 ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
ATG P PT+ W D L ++ + +G Y+C A N + + R
Sbjct: 3141 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3200
Query: 215 VKVTVNYPPYISEAKGTGVPVGQK 238
V V P S TGV G+K
Sbjct: 3201 FLV-VRGEPQGSWGSMTGVINGRK 3223
Score = 50.1 bits (118), Expect = 3e-06
Identities = 56/242 (23%), Positives = 90/242 (37%), Gaps = 41/242 (16%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE--ISSDISINEGNNISLT 156
S+ + +V D G Y C + + R L+V V P I E +++S G +++L
Sbjct: 58 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 117
Query: 157 CIATGRPEPTVTWRHISPKAVG---------------------FVSEDEYLEIQGITREQ 195
C A G P P + W + VG + E + L I +
Sbjct: 118 CDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGR 176
Query: 196 SG--DYECSASNDVAAPVVRRVKVTVNY-------PPYISEAKGTGVP------VGQKGT 240
SG + S AP + + PP G G G
Sbjct: 177 SGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVE 236
Query: 241 LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
LQC S VP+ + +W KD + ++ G ++V+ + ++ +V D G Y CVA +
Sbjct: 237 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSP 294
Query: 301 LG 302
G
Sbjct: 295 AG 296
Score = 35.4 bits (80), Expect = 0.075
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)
Query: 17 VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
V+ +++ LV PV F ++TVR G+ LRC T + WL L
Sbjct: 3105 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158
Query: 76 YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
A T S+ ++NV+ D G Y C T+R L+V+
Sbjct: 3159 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 3207
Query: 136 PK 137
P+
Sbjct: 3208 PQ 3209
Score = 34.7 bits (78), Expect = 0.13
Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 6/79 (7%)
Query: 243 CEASAVPSAEFQWYKD-DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
C P + W K + G+ GV V L +VS D G+Y C A+N++
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEE---GSLFLASVSPADSGDYECQATNEV 80
Query: 302 GHTN--ASIMLFGPGAVSE 318
G T+ A ++++ P ++ E
Sbjct: 81 GSTSRRAKLVVYVPPSIRE 99
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 85.5 bits (210), Expect = 6e-17
Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 12/213 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
+ I + D G Y C + + L+VQV P I D+S EG++ L C A
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779
Query: 160 TGRPEPTVTWRHISPKAVG-----FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
G PEP +TW G + L ++ + + +G Y C+A N V RR
Sbjct: 2780 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRR 2838
Query: 215 VKVTVNYPPYISEAKG-TGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V +T+ P + G + +G + L+C A P+ W +D+ + EG V
Sbjct: 2839 VHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG-----VSE 2893
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNA 306
+ S L VS D G Y C A N++G T A
Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 2926
Score = 82.0 bits (201), Expect = 7e-16
Identities = 82/269 (30%), Positives = 106/269 (39%), Gaps = 20/269 (7%)
Query: 43 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 102
D V VR G+ A L C D A + Y L R L Q +EI
Sbjct: 1758 DAVLVRVGDKAVLSCETD------ALPEPTVTWYKDGQPLVLAQRTQALRGGQR---LEI 1808
Query: 103 QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSD-ISINEGNNISLTCIATG 161
Q V D+G Y+C V L VQV P ++ +S G+ + LTC +G
Sbjct: 1809 QEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSG 1868
Query: 162 RPEPTVTW----RHISPKAV-GFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVK 216
P PTVTW + AV G VS L++ + Q+G Y C A N A +
Sbjct: 1869 VPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEARKDFV 1927
Query: 217 VTVNYPPYISE---AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
V V P I A+ V GQ+ L CEA P + W KD L + G +
Sbjct: 1928 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ-DMGPHLRF 1986
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L+ + D G YTCVA N G
Sbjct: 1987 YLDGGSLVLKGLRASDAGAYTCVAHNPAG 2015
Score = 80.9 bits (198), Expect = 2e-15
Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 31/294 (10%)
Query: 21 LLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGN 79
LL L P PV GD + ++ VTV + +L+C + N V ++WL
Sbjct: 1554 LLVLTP---PVILGDTE--ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL------ 1602
Query: 80 DKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV 139
+ PR+ +L + Q +++ +V D Y C + L VQV P+I
Sbjct: 1603 -PFSPSPRLQVLEDGQV---LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1658
Query: 140 EISSD-ISINEGNNISLTCIATGRPEPTVTWRHISP-----KAVGFVSEDEYLEIQGITR 193
+ + ++ +++SL C P P VTW S + V + L++
Sbjct: 1659 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1718
Query: 194 EQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-----GTGVPVGQKGTLQCEASAV 248
SG Y C A N A + V+++V PP +A V VG K L CE A+
Sbjct: 1719 SDSGMYTCEALN-AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1777
Query: 249 PSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
P WYKD + L+ ++ + +L D G Y+C SN G
Sbjct: 1778 PEPTVTWYKDGQPLVLAQRTQALRGG---QRLEIQEAQVSDKGLYSCKVSNVAG 1828
Score = 80.5 bits (197), Expect = 2e-15
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 11/219 (5%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIA 159
++I+ VD+ DEG YTC+ V L V V P I + ++ E +++L C+A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 160 TGRPEPTVTW----RHISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAPVVRR 214
+G P P V+W + +S VS D L I+ +G Y C ASN VA R
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASN-VAGSTELR 686
Query: 215 VKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLI-EGKKGVKV 271
+ VN PP I+ P V L C A+ PS W KD + G G++V
Sbjct: 687 YGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 746
Query: 272 ENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
P L + D G Y+CVA + +G ++L
Sbjct: 747 --FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVL 783
Score = 79.0 bits (193), Expect = 6e-15
Identities = 76/277 (27%), Positives = 115/277 (41%), Gaps = 33/277 (11%)
Query: 45 VTVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQ 103
+ V G++A L C + ++ W L G D + P VLL Q S
Sbjct: 1173 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLLQVLQANLS---- 1227
Query: 104 NVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSD--ISINEGNNISLTCI 158
G Y+C KT L V ++P I+ E S+D +++ N ISL C
Sbjct: 1228 -----SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 1282
Query: 159 ATGRPEPTVTWRHI-----SPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 213
A P P +TW + + + + L+I +E +G Y C +N++ V+
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGE-AVK 1341
Query: 214 RVKVTVNYPPYISE--------AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEG 265
V V PP IS+ K V TL+CE+ AVP +WYKD + +
Sbjct: 1342 NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS 1401
Query: 266 KKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+ ++V L ++ VS D G Y CVA+N G
Sbjct: 1402 SR-LQVLGEGRLLQIQPTQVS--DSGRYLCVATNVAG 1435
Score = 79.0 bits (193), Expect = 6e-15
Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 9/217 (4%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
++EI G YTCS + V L VQ SP + + S + + L C
Sbjct: 2629 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCE 2688
Query: 159 ATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
A+G P PT+TW+ +++ V L I + E +G+Y C A N A + +
Sbjct: 2689 ASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNS-AGSAMGK 2747
Query: 215 VKVTVNYPPYISEA-KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVEN 273
++ V PP I G L C+A P W KD + + G +G K
Sbjct: 2748 TRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQP-VSGAEG-KFTI 2805
Query: 274 RPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+P +L+ N+ D G YTC A N +G + L
Sbjct: 2806 QP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2841
Score = 76.3 bits (186), Expect = 4e-14
Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 28/262 (10%)
Query: 48 RQGESATLRCTI-DNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVD 106
R GE T+ C + + V+WL L L R +L + T + I V
Sbjct: 2044 RPGELVTMVCPVRGSPPIHVSWLKDGLPLP-------LSQRTLLHGSGHT---LRISKVQ 2093
Query: 107 VYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI--VEISSDISINEGNNISLTCIATGRPE 164
+ D G +TC + L VQV P + VE +D+ + G+ + L C A G P
Sbjct: 2094 LADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153
Query: 165 PTVTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
P V+W + P + + L+++ + SG Y C A ++ A R ++TV PP
Sbjct: 2154 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSE-AGEARRHFQLTVMEPP 2212
Query: 224 YISEA---KGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKL 280
+I ++ + G L C+A P W+KD + L ++EN +++
Sbjct: 2213 HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRV 2266
Query: 281 IFFNVSEHDYGNYTCVASNKLG 302
+ D G YTC+A + G
Sbjct: 2267 L----RVRDAGLYTCLAESPAG 2284
Score = 73.2 bits (178), Expect = 3e-13
Identities = 76/300 (25%), Positives = 114/300 (38%), Gaps = 44/300 (14%)
Query: 42 MDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100
+ N+T TL C + + W + G D + L +L TQTQ
Sbjct: 1077 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW-MLKMTQTQEQ- 1134
Query: 101 EIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNNISLTCI 158
D G Y+C + + V V P I ++ I + +G L C
Sbjct: 1135 --------DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCN 1186
Query: 159 ATGRPEPTVTW------------RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASND 206
TG P+P +TW HISP V L++ +G Y C A+N
Sbjct: 1187 VTGHPQPKLTWFKDGRPLARGDAHHISPDGV-------LLQVLQANLSSAGHYSCIAANA 1239
Query: 207 VAAPVVRRVKVTVNYPPYI------SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDK 260
V + +++V P I S + V V +L CEA A PS W KD
Sbjct: 1240 VGEK-TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298
Query: 261 RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAVSE 318
E + +++ P L N + D G YTCV +N+LG N + + P ++S+
Sbjct: 1299 P-FEASRNIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1355
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 22/258 (8%)
Query: 82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEI 141
W D +L + + S++++ V D G Y+C ++ L V P I +
Sbjct: 2158 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217
Query: 142 S--SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDY 199
+++S+ G + L C A G P+P +TW H +A+ + E+ + + +G Y
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRL-ENNSRATRVLRVRDAGLY 2275
Query: 200 ECSASNDVAAPVVRRVKVTVNYPPYISEAKG----TGVPVGQKGTLQCEASAVPSAEFQW 255
C A + A + + +V V PP I +G G+ GQ L+C A P+ + W
Sbjct: 2276 TCLAESPAGA-IEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQL-VLECSVEAEPAPKITW 2333
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML----- 310
++D L E E FL +S D G+Y+C A N G T+ + +
Sbjct: 2334 HRDGIVLQEDAHTQFPERGRFLQLQA---LSTADSGDYSCTARNAAGSTSVAFRVEIHTV 2390
Query: 311 ----FGPGAVSEVSNGTS 324
GP AV+ N T+
Sbjct: 2391 PTIRSGPPAVNVSVNQTA 2408
Score = 72.0 bits (175), Expect = 7e-13
Identities = 57/200 (28%), Positives = 83/200 (41%), Gaps = 11/200 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D + C V + + V V P I + +D ++ + LTC +TG P PTV+
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607
Query: 169 W----RHISPKAVGF-VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W + + G+ VS LEI +G Y CSA N A + V +TV P
Sbjct: 2608 WSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS-AGVAHKHVFLTVQASP 2666
Query: 224 YISEAKGTGVPVGQKGT-LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIF 282
+ V ++ L CEAS +P W K+ + GV + P +L
Sbjct: 2667 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPG-GQLRI 2722
Query: 283 FNVSEHDYGNYTCVASNKLG 302
+ S D GNY C+A N G
Sbjct: 2723 AHASPEDAGNYLCIAKNSAG 2742
Score = 71.6 bits (174), Expect = 9e-13
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 20/222 (9%)
Query: 110 EGPYTCSVQTDNHPKTSRVHLIVQVSPKIV---EISSDISINEGNNISLTCIATGRPEPT 166
EG YTC + + L V V P+I E + +S+ + +L C ATG+P PT
Sbjct: 948 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT 1007
Query: 167 VTWRHISPKAVG------FVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVN 220
VTW + VG ++ + L ++ +G Y C A N +A R+ +++V
Sbjct: 1008 VTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAEN-LAGRAERKFELSVL 1065
Query: 221 YPPY----ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPF 276
PP + + TL CEA +P +W++ ++ + G+ +
Sbjct: 1066 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 1125
Query: 277 LSKLIFFNVSEHDYGNYTCVASNKLGHT--NASIMLFGPGAV 316
L E D G Y+C+ASN+ G N S+ + P ++
Sbjct: 1126 LK---MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI 1164
Score = 70.1 bits (170), Expect = 3e-12
Identities = 65/246 (26%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 79 NDKWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQ 133
N W D +L ++T+ Y+ +++ D G YTC L V
Sbjct: 251 NITWFKDG-ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309
Query: 134 VSPKIVEISSD---ISINEGNNISLTCIATGRPEPTVTWRH-----ISPKAVGFVSEDEY 185
V P I + G ++L C+A G P PT++W H ++
Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV 369
Query: 186 LEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTG---VPVGQKGTLQ 242
L ++ SG Y C AS+ A V + V V PP + A+G G VGQ L
Sbjct: 370 LRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 428
Query: 243 CEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
C+AS P QW ++ R E GV+V ++ + L +V G + C A+N+ G
Sbjct: 429 CQASGSPVPTIQWLQNG-RPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAG 485
Query: 303 HTNASI 308
A +
Sbjct: 486 TAGAEV 491
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/222 (26%), Positives = 90/222 (40%), Gaps = 15/222 (6%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV----EISSDISINEGNNISL 155
++I V + G Y+C + L+V P I+ E+ ++++N + +SL
Sbjct: 1524 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSL 1583
Query: 156 TCIATGRPEPTVTWRH----ISPKAVGFVSED-EYLEIQGITREQSGDYECSASNDVAAP 210
C A G P PT++W SP V ED + L++ + Y C A N A
Sbjct: 1584 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ-AGS 1642
Query: 211 VVRRVKVTVNYPPYIS--EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 268
+ + V PP I+ + + + +L C+ A P+ E WYKD + L G
Sbjct: 1643 AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL---SLG 1699
Query: 269 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
+V P L D G YTC A N G + L
Sbjct: 1700 EEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1741
Score = 69.3 bits (168), Expect = 5e-12
Identities = 76/279 (27%), Positives = 111/279 (39%), Gaps = 27/279 (9%)
Query: 44 NVTVRQGESATLRCTIDN-RVTRVAWLNRSTIL--------YAGNDKWCLDPRVVLLSNT 94
NV+ G+S TL C + V + WL + ++ Y + W LL
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 95 QTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV--EISSDISINEGNN 152
Q S+ + D G Y+C + HL+V P ++ + ++ G +
Sbjct: 87 Q---SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD 143
Query: 153 ISLTCIATGRPEPTVTW-RHISPKAVG----FVSED-EYLEIQGITREQSGDYECSASND 206
+ L C +G P P V W + P G V ED + L I G G Y+C A +
Sbjct: 144 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 203
Query: 207 VAAPVVRRVKVTVNYPPYISEAKGTG-VPVGQKGTLQ--CEASAVPSAEFQWYKDDKRLI 263
A R ++ V+ PP I + TG V V + +Q CEA VP+ W+KD L
Sbjct: 204 -AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 262
Query: 264 EGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
K V +L D G YTC ASN +G
Sbjct: 263 TSTKVVYTRGG---RQLQLGRAQSSDAGVYTCKASNAVG 298
Score = 67.8 bits (164), Expect = 1e-11
Identities = 57/223 (25%), Positives = 94/223 (42%), Gaps = 16/223 (7%)
Query: 100 IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKI-VEISSDISINEGNNISLTCI 158
+++ DV+D G YTC +L V V+P + S +++ EG+ L+C
Sbjct: 844 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCE 903
Query: 159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPV 211
G P P ++WR G + +++ G Q G Y C SN V
Sbjct: 904 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN-VVGNS 962
Query: 212 VRRVKVTVNYPPYISEAK--GTGVPVGQKG--TLQCEASAVPSAEFQWYKDDKRLIEGKK 267
+ +++ V+ PP I+ + T V V Q G TL+C A+ P W +D + + +
Sbjct: 963 SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP-VGAEL 1021
Query: 268 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
G++++N+ L G Y+CVA N G L
Sbjct: 1022 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1062
Score = 66.2 bits (160), Expect = 4e-11
Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 19/232 (8%)
Query: 88 VVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS 142
+VL + TQ+ +++Q + D G Y+C+ + + + + P I
Sbjct: 2338 IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 2397
Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRH----ISPKAVGF-VSEDEYLEIQGITREQSG 197
++++ L C A G P P V+WR + P++ F + + L IQ + + +G
Sbjct: 2398 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2457
Query: 198 DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYK 257
Y C ASN + R + P + L CEAS P W+K
Sbjct: 2458 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 2517
Query: 258 D----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTN 305
D D RL +G + N L+ D + CV SN++G +
Sbjct: 2518 DGQKLDFRLQQGAYRLLPSN-----ALLLTAPGPQDSAQFECVVSNEVGEAH 2564
Score = 65.1 bits (157), Expect = 9e-11
Identities = 56/238 (23%), Positives = 99/238 (41%), Gaps = 37/238 (15%)
Query: 98 YSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEIS--SDISINE-----G 150
+ ++I N D G YTC V + H+ V + P I + +++ + E
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 151 NNISLTCIATGRPEPTVTW----RHISPKA-VGFVSEDEYLEIQGITREQSGDYECSASN 205
+ ++L C + P PT+ W + ++P + + + E L+IQ SG Y C A+N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 206 DVAAPVVRRVKVTVNYPPYIS----------------EAKG-----TGVPVGQKGTLQCE 244
VA + V + PP EA+G + L C+
Sbjct: 1433 -VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491
Query: 245 ASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
+A+P + WY++D+ L G + ++ L + V + G Y+C ASN++G
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL---VRAENAGRYSCKASNEVG 1546
Score = 60.8 bits (146), Expect = 2e-09
Identities = 63/239 (26%), Positives = 94/239 (39%), Gaps = 22/239 (9%)
Query: 81 KWCLDPRVVLLSNTQTQYS-----IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
+W D + VL Q + I V DEG Y C + + L V
Sbjct: 159 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 218
Query: 136 PKI--VEISSDISINEGNNISLTCIATGRPEPTVTW------RHISPKAVGFVSEDEYLE 187
P I + ++++ E + + L C A G P P +TW S K V + L+
Sbjct: 219 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV-YTRGGRQLQ 277
Query: 188 IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV----GQKGTLQC 243
+ +G Y C ASN V A + ++ V PP I A G V G+ L+C
Sbjct: 278 LGRAQSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC 336
Query: 244 EASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 302
A PS W+ + + E + ++E S L + E G Y+CVAS+ G
Sbjct: 337 VARGHPSPTLSWHHEGLPVAESNES-RLETDG--SVLRLESPGEASSGLYSCVASSPAG 392
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/210 (23%), Positives = 91/210 (43%), Gaps = 11/210 (5%)
Query: 109 DEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVT 168
D G Y+C + V L V + P I+ ++S+ +++L C + P P ++
Sbjct: 762 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821
Query: 169 W----RHISPKAVGFVSEDE-YLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
W R + P+ +S D+ L++ +G Y C A N A + + V P
Sbjct: 822 WWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ-AGHSEKHYNLNVWVAP 880
Query: 224 Y--ISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI 281
+ E+ V G L CE VP + W KD + L +G +++ + +L+
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL--PGEGAGLQHVSAVGRLL 938
Query: 282 FFNVSE-HDYGNYTCVASNKLGHTNASIML 310
+ ++ G YTC SN +G+++ + L
Sbjct: 939 YLGQAQLAQEGTYTCECSNVVGNSSQDLQL 968
Score = 60.5 bits (145), Expect = 2e-09
Identities = 80/295 (27%), Positives = 116/295 (39%), Gaps = 33/295 (11%)
Query: 25 VPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDN-RVTRVAWLNRSTILYAGNDKWC 83
VPT +RSG P A+ NV+V Q +A L C D V+W D+
Sbjct: 2390 VPT---IRSG----PPAV-NVSVNQ--TALLPCQADGVPAPLVSWRK---------DRVP 2430
Query: 84 LDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS 143
LDPR + S+ IQ V D G Y C L V P I S
Sbjct: 2431 LDPRSPRFE-ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489
Query: 144 DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEY-------LEIQGITREQS 196
++++ L C A+G P+P V W K + + Y L + + S
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 2549
Query: 197 GDYECSASNDVAAPVVRRVKVTVNYPPYISEAK-GTGVPVGQKGTLQCEASAVPSAEFQW 255
+EC SN+V R +VTV+ PP I++ + V + L C ++ +P+ W
Sbjct: 2550 AQFECVVSNEV-GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSW 2608
Query: 256 YKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K +L G +G P + I + H G YTC A N G + + L
Sbjct: 2609 SKAGAQL--GARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFL 2660
Score = 59.7 bits (143), Expect = 4e-09
Identities = 64/272 (23%), Positives = 109/272 (40%), Gaps = 24/272 (8%)
Query: 46 TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
++R G+ LRC T R+ W ND+ P +S +++
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGW--------TVNDR----PVTEGVSEQDGGSTLQRAA 2904
Query: 105 VDVYDEGPYTCSVQTDNHPKTSRVHLI-VQVSPKIV-EISSDISINEGNNISLTCIATGR 162
V D G Y C + + +T V + V+ +P + E S + G +I L C+ G
Sbjct: 2905 VSREDSGTYVCWAE-NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGD 2963
Query: 163 PEPTVTWRH----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVT 218
P P + W + + ++ L I+ R+ +G Y+C A N++ + V
Sbjct: 2964 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVL 3023
Query: 219 VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLS 278
+ P + E + V G L+C+A+ P+ +W + + L ++ + +
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----G 3079
Query: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
L NV D G Y CVA N LG A L
Sbjct: 3080 SLWLENVETGDAGTYDCVAHNLLGSATARAFL 3111
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 5/144 (3%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S+ I+ + D G Y C + + V L++Q +P D+++ G++++L C
Sbjct: 2990 SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3049
Query: 159 ATGRPEPTVTWRHISPKAVGF----VSEDEYLEIQGITREQSGDYECSASNDVAAPVVRR 214
ATG P PT+ W D L ++ + +G Y+C A N + + R
Sbjct: 3050 ATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARA 3109
Query: 215 VKVTVNYPPYISEAKGTGVPVGQK 238
V V P S TGV G+K
Sbjct: 3110 FLV-VRGEPQGSWGSMTGVINGRK 3132
Score = 52.4 bits (124), Expect = 6e-07
Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 28/184 (15%)
Query: 143 SDISINEGNNISLTCIATGRPEPTVTWRHISPKAVG---------------------FVS 181
+++S G +++L C A G P P + W + VG +
Sbjct: 26 ANVSGMAGQSLTLECDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLGWGQVGGHRLLD 84
Query: 182 EDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT- 240
E + L I SG Y C A N A R + V PP + A +G G
Sbjct: 85 EGQSLHFPRIQEGDSGLYSCRAENQ-AGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD 143
Query: 241 --LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVAS 298
LQC S VP+ + +W KD + ++ G ++V+ + ++ +V D G Y CVA
Sbjct: 144 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAF 201
Query: 299 NKLG 302
+ G
Sbjct: 202 SPAG 205
Score = 35.4 bits (80), Expect = 0.075
Identities = 31/122 (25%), Positives = 47/122 (38%), Gaps = 18/122 (14%)
Query: 17 VSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLNRSTIL 75
V+ +++ LV PV F ++TVR G+ LRC T + WL L
Sbjct: 3014 VAKKVVILVLQSAPV------FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3067
Query: 76 YAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVS 135
A T S+ ++NV+ D G Y C T+R L+V+
Sbjct: 3068 RASR-----------RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE 3116
Query: 136 PK 137
P+
Sbjct: 3117 PQ 3118
Score = 33.1 bits (74), Expect = 0.37
Identities = 37/123 (30%), Positives = 49/123 (39%), Gaps = 27/123 (21%)
Query: 222 PPYISE----AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG--------- 268
PP I E A +G+ GQ TL+C+A+ P E W K D +L+ G
Sbjct: 16 PPSIREDGRKANVSGM-AGQSLTLECDANGFPVPEIVWLK-DAQLVGVPLGWAGYGWDLG 73
Query: 269 -VKVENRPFLSK---LIFFNVSEHDYGNYTCVASNKLGHTNASIML--------FGPGAV 316
+V L + L F + E D G Y+C A N+ G L G GA
Sbjct: 74 WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 133
Query: 317 SEV 319
EV
Sbjct: 134 QEV 136
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 30/273 (10%)
Query: 55 LRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPY 113
LRC + N R +W +L G+DK ++ + +T+ ++++N+ D Y
Sbjct: 157 LRCVANSNPPVRYSWRRGQEVLLQGSDKG-VEIYEPFFTQGETKI-LKLKNLRPQDYANY 214
Query: 114 TCSVQTDNHPKTSRVHLIVQVSPKIVE------ISSDISINEGNNISLTCIATG-RPEPT 166
+C N + ++S K + I +N G I+L C+ TG P P+
Sbjct: 215 SCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPS 274
Query: 167 VTW-RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP-------VVRRVK-- 216
+TW R V L I IT + +G Y C A+N+V P +VR +K
Sbjct: 275 LTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG 334
Query: 217 -VTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAE--FQWYKDDKRLIEGKKGVKVEN 273
+ PY K + +G++ + C+ AVPS E F W+K+ + L ++ V +
Sbjct: 335 RFWITPDPY---HKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQT 391
Query: 274 RPFLS----KLIFFNVSEHDYGNYTCVASNKLG 302
P +S L ++ D+G YTCVAS K G
Sbjct: 392 DPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGG 424
Score = 80.9 bits (198), Expect = 2e-15
Identities = 51/170 (30%), Positives = 82/170 (48%), Gaps = 18/170 (10%)
Query: 146 SINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSE----DEYLEIQGITREQSGDYEC 201
+I EG + LTC+ TG P P + W + A + +E L I I R Q G Y C
Sbjct: 51 TIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYC 110
Query: 202 SASNDVAAPVVRRVKVTVNY--PPYISEAKGTGVPVGQ-----KGTLQCEASAVPSAEFQ 254
A N + +P ++ ++V V Y P ++ + G Q L+C A++ P +
Sbjct: 111 KAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYS 170
Query: 255 WYKDDKRLIEGK-KGVKVENRPFLSK-----LIFFNVSEHDYGNYTCVAS 298
W + + L++G KGV++ PF ++ L N+ DY NY+C+AS
Sbjct: 171 WRRGQEVLLQGSDKGVEI-YEPFFTQGETKILKLKNLRPQDYANYSCIAS 219
Score = 59.7 bits (143), Expect = 4e-09
Identities = 60/241 (24%), Positives = 102/241 (42%), Gaps = 28/241 (11%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIV-------EISSDISINEGN 151
+++I ++ D G YTC V + S + + V +S V + S + EG+
Sbjct: 401 NLDIIDLKFTDFGTYTC-VASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGD 459
Query: 152 NISLTCIATGRPEPTVTWRHISPK------AVGFVSEDEYLEIQGITREQSGDYECSASN 205
I L C TG+P+P + W + ++ S D L I ++RE SG Y C S
Sbjct: 460 TIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQ 519
Query: 206 DVAAPVVRR---VKVTVNYPPYISEAKGTGVPVGQ--KGTLQC---EASAVPSAEFQWYK 257
V R V++ V YPP + E + GQ T+ C A + ++W
Sbjct: 520 YNGFNVKPREALVQLIVQYPPAV-EPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRL 578
Query: 258 DDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVS 317
+K L G + +++ + ++ ++S +YG Y C N+ G S ++ G
Sbjct: 579 GNKLLRTG----QFDSQEY-TEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAP 633
Query: 318 E 318
E
Sbjct: 634 E 634
Score = 32.0 bits (71), Expect = 0.83
Identities = 57/302 (18%), Positives = 108/302 (35%), Gaps = 78/302 (25%)
Query: 46 TVRQGESATLRCTIDNRVT-RVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQN 104
T+R+GE+ L C + ++ W + + +D++ ++ ++ I N
Sbjct: 51 TIREGETLELTCLVTGHPRPQIRWTKTAG---SASDRF--------QDSSVFNETLRITN 99
Query: 105 VDVYDEGPYTCSVQTD-NHP--KTSRVHLIVQVSPKIVEISSDISINEG----NNISLTC 157
+ + G Y C + P K+ RV + P + S E + L C
Sbjct: 100 IQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRC 159
Query: 158 IATGRPEPTVTWRHI-------SPKAVGFVS------EDEYLEIQGITREQSGDYECSAS 204
+A P +WR S K V E + L+++ + + +Y C AS
Sbjct: 160 VANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIAS 219
Query: 205 -----------------NDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASA 247
N A+P +K+ V+ P ++ G+ TL C +
Sbjct: 220 VRNVCNIPDKMVSFRLSNKTASP---SIKLLVDDPIVVNP--------GEAITLVCVTTG 268
Query: 248 -VPSAEFQWYKD-----DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKL 301
P+ W + +K ++ G L ++ D G Y+C+A+N +
Sbjct: 269 GEPAPSLTWVRSFGTLPEKTVLNG------------GTLTIPAITSDDAGTYSCIANNNV 316
Query: 302 GH 303
G+
Sbjct: 317 GN 318
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 83.6 bits (205), Expect = 2e-16
Identities = 66/238 (27%), Positives = 94/238 (39%), Gaps = 16/238 (6%)
Query: 89 VLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISIN 148
V + N S+ I N+ + G YTC + + + LIV+V PK V D
Sbjct: 643 VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGI 702
Query: 149 EGNNISLTCIATGRPEPTVTWR--------HISPKAVG---FVSEDEYLEIQGITREQSG 197
G + L C A G P PT+ W+ P A+ V + L I+ + E SG
Sbjct: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
Query: 198 DYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPV-GQKGTLQCEASAVPSAEFQWY 256
Y C SNDV A V + + +TV P I+ T + GQK + C A +W
Sbjct: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822
Query: 257 KDDK----RLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 310
K+D+ + K +S L D G ++C A N G I L
Sbjct: 823 KEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQL 880
Score = 66.2 bits (160), Expect = 4e-11
Identities = 67/282 (23%), Positives = 109/282 (38%), Gaps = 17/282 (6%)
Query: 29 VPVRSGDATFPKAMDNVTVRQGESATLRCTIDNR-VTRVAW-LNRSTILYAGNDKWCLDP 86
V + G A V E +L C + + + W L+ IL G+ +
Sbjct: 400 VVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ-- 457
Query: 87 RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDIS 146
++ S + I + V D G Y C+ + + V+ P + +I+
Sbjct: 458 --MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKNIT 514
Query: 147 INEGNNISLTCIATGRPEPTVTWRHISP------KAVGFVSEDEYLEIQGITRE-QSGDY 199
G + + C G P ++ W S + V F + L++ + +E G+Y
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGT-LKLSDVQKEVDEGEY 573
Query: 200 ECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEA-SAVPSAEFQWYKD 258
C+ + V VTV PP+I + +GQ+ + C S W KD
Sbjct: 574 TCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633
Query: 259 DKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
R I G GV ++N F S L N+S GNYTC+A N+
Sbjct: 634 G-RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE 674
Score = 61.2 bits (147), Expect = 1e-09
Identities = 75/277 (27%), Positives = 112/277 (40%), Gaps = 34/277 (12%)
Query: 43 DNVTVRQGESATLRCTIDNRV----TRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQY 98
D T+R G A +C I + V T V+W + L +G+ L+++T Y
Sbjct: 132 DQKTMR-GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSR--------FLITSTGALY 182
Query: 99 SIEIQNVD-VYDEGPYTCSVQTDNHPKTSRVHLIVQ----VSPKIVEISSDISINEGNNI 153
++QN D +Y+ T T +++ L V +P I++ G +
Sbjct: 183 IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRV 242
Query: 154 SLTCIATGRPEPTVTW-RHISPKAVG--FVSEDEYLEIQGITREQSGDYECSASNDV-AA 209
L C A G PEP W + P + F L I+ I SG Y C SN A
Sbjct: 243 ELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTA 302
Query: 210 PVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK-- 267
V+ R+ V IS K VG + +L C + E WY++ + L GK
Sbjct: 303 KVIGRLYVKQPLKATISPRK-VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVR 361
Query: 268 --GVKVENRPFLSKLIFFNVSEHDYGNYTC-VASNKL 301
G+ EN LI ++ + D G Y C V +KL
Sbjct: 362 ITGINHEN------LIMDHMVKSDGGAYQCFVRKDKL 392
Score = 37.4 bits (85), Expect = 0.020
Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 236 GQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
GQ+ L C+A P +++W KD+ L + K ++ L+ N+ D G+Y C
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT-----VTGLLIENIRPSDSGSYVC 293
Query: 296 VASNKLG 302
SN+ G
Sbjct: 294 EVSNRYG 300
Score = 33.1 bits (74), Expect = 0.37
Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 9/111 (8%)
Query: 121 NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV 180
N + V + + +I+ S ++ +I L C A G P P V W S V
Sbjct: 1271 NSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV 1330
Query: 181 SEDEYLE--------IQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223
+ D I+ + E SG Y C A+N+ + + + + V PP
Sbjct: 1331 TIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI-ILNLQVQVPP 1380
Score = 32.0 bits (71), Expect = 0.83
Identities = 20/67 (29%), Positives = 31/67 (46%), Gaps = 10/67 (14%)
Query: 241 LQCEASAVPSAEFQWYKDDKRL-----IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTC 295
L C+A PS +W KD I+G++ + N F+ + V D G Y+C
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI-FSNGSFIIR----TVKAEDSGYYSC 1359
Query: 296 VASNKLG 302
+A+N G
Sbjct: 1360 IANNNWG 1366
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 83.6 bits (205), Expect = 2e-16
Identities = 75/278 (26%), Positives = 117/278 (42%), Gaps = 30/278 (10%)
Query: 40 KAMDNVTVRQGESATLRCTIDNRVTRV--AWLNRSTILYAGNDKWCLDPRVVLLSNTQTQ 97
K V+VR+G+ L C + AW LY D + R V +Q
Sbjct: 127 KTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQED----NRRFV----SQET 178
Query: 98 YSIEIQNVDVYDEGPYTC---------SVQTDNHPKTSRVHLIV-QVSPKI-VEISSDIS 146
++ I V+ D G YTC SVQ P R ++ + PKI V I
Sbjct: 179 GNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQ 238
Query: 147 INEGNNISLTCIATGRPEPTVTWRHIS----PKAVGFVSEDEYLEIQGITREQSGDYECS 202
+ +++ L C A G P P ++WR + P V + LEI +E G YEC
Sbjct: 239 AAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECI 298
Query: 203 ASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL 262
ASN + + + P + + + T + + +C+AS P+ + W K+ +RL
Sbjct: 299 ASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERL 358
Query: 263 IEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 300
++ +++EN + + NVS D G Y C A NK
Sbjct: 359 -NPEERIQIENGTLI--ITMLNVS--DSGVYQCAAENK 391
Score = 73.2 bits (178), Expect = 3e-13
Identities = 62/268 (23%), Positives = 112/268 (41%), Gaps = 24/268 (8%)
Query: 43 DNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 101
+ + + S L C + N V ++W G K+ +++Q +E
Sbjct: 235 ETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKY-----------SKSQAILE 283
Query: 102 IQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATG 161
I N DEG Y C ++ LI P+ + + ++ +N+ C A+G
Sbjct: 284 IPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASG 343
Query: 162 RPEPTVTW----RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR-RVK 216
+P P TW ++P+ E+ L I + SG Y+C+A N ++
Sbjct: 344 KPNPWYTWLKNGERLNPEE-RIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELR 402
Query: 217 VTVNYPPYISE--AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR 274
V + P + K + V VG + C+ +A P A W + + L + K+ +E+
Sbjct: 403 VLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLED- 461
Query: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLG 302
L +N++ D G+YTC+A+N+ G
Sbjct: 462 ---GSLKIYNITRSDAGSYTCIATNQFG 486
Score = 43.1 bits (100), Expect = 4e-04
Identities = 48/179 (26%), Positives = 72/179 (40%), Gaps = 23/179 (12%)
Query: 136 PKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGI---- 191
P V D+S +E + L C A G P P W+ + + F Y G
Sbjct: 32 PHDVIFPLDLSKSE---VILNCAANGYPSPHYRWKQ-NGTDIDFTMSYHYRLDGGSLAIN 87
Query: 192 ---TREQSGDYECSASNDVAAPVVRRVKVTVNY-PPYISEAKGT-GVPVGQKGTLQC-EA 245
T + G Y+C A+N + + R+ K+ Y + ++ + T V GQ L C
Sbjct: 88 SPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPP 147
Query: 246 SAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSK----LIFFNVSEHDYGNYTCVASNK 300
+ W +D L V+ +NR F+S+ L V D GNYTC +NK
Sbjct: 148 PHFGDLSYAWTFNDNPLY-----VQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNK 201
Score = 41.6 bits (96), Expect = 0.001
Identities = 49/192 (25%), Positives = 75/192 (39%), Gaps = 41/192 (21%)
Query: 143 SDISINEGNNISLTCIATGRP----EPTVTWR------HISPKAVGFVSEDE-YLEIQGI 191
S +S+ EG + L C G P + + W ++ FVS++ L I +
Sbjct: 130 STVSVREGQGVVLLC---GPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKV 186
Query: 192 TREQSGDYECSASNDVA--------APVVRRV---------KVTVNYPPYISEAKGTGVP 234
G+Y C +N A P+V+R K+ V +P I AK + V
Sbjct: 187 EPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVK 246
Query: 235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYT 294
L+C A P + W + D + GK VK + ++ N + D G Y
Sbjct: 247 ------LECFALGNPVPDISWRRLDGSPLPGK--VKYSKSQAILEIP--NFQQEDEGFYE 296
Query: 295 CVASNKLGHTNA 306
C+ASN G A
Sbjct: 297 CIASNLRGRNLA 308
Score = 28.5 bits (62), Expect = 9.2
Identities = 19/71 (26%), Positives = 29/71 (40%)
Query: 99 SIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCI 158
S++I N+ D G YTC + LIV+ I S + + G +I L C
Sbjct: 463 SLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQ 522
Query: 159 ATGRPEPTVTW 169
+ P V +
Sbjct: 523 VSHDPSIEVVF 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,387,520
Number of Sequences: 37866
Number of extensions: 575708
Number of successful extensions: 5423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 260
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 1490
Number of HSP's gapped (non-prelim): 2119
length of query: 344
length of database: 18,247,518
effective HSP length: 103
effective length of query: 241
effective length of database: 14,347,320
effective search space: 3457704120
effective search space used: 3457704120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.