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Search of human proteins with 7657381
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog
[Homo sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 1005 0.0
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 117 3e-26
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 117 3e-26
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 116 5e-26
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 114 2e-25
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 111 1e-24
gi|32189425 WD repeat domain 69 [Homo sapiens] 108 9e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens] 108 1e-23
gi|16554629 WD repeat domain 5 [Homo sapiens] 107 2e-23
gi|16554627 WD repeat domain 5 [Homo sapiens] 107 2e-23
gi|26665869 WD repeat domain 51B [Homo sapiens] 107 3e-23
gi|23199987 WD repeat domain 5B [Homo sapiens] 100 2e-21
gi|113865883 WD repeat domain 38 [Homo sapiens] 99 1e-20
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 97 3e-20
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 97 4e-20
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 94 2e-19
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 92 1e-18
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 91 2e-18
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 89 7e-18
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 88 2e-17
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 88 2e-17
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 88 2e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 88 2e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 87 3e-17
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 87 3e-17
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 87 3e-17
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 86 6e-17
gi|13376840 WD repeat domain 61 [Homo sapiens] 84 2e-16
gi|18874090 WD repeat domain 48 [Homo sapiens] 82 9e-16
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 82 9e-16
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 1005 bits (2599), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP 60
MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP
Sbjct: 1 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP 60
Query: 61 IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL 120
IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL
Sbjct: 61 IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL 120
Query: 121 TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA 180
TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA
Sbjct: 121 TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA 180
Query: 181 TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG 240
TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG
Sbjct: 181 TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG 240
Query: 241 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ 300
GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ
Sbjct: 241 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ 300
Query: 301 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360
VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP
Sbjct: 301 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360
Query: 361 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD
Sbjct: 361 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
Query: 421 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG 480
LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG
Sbjct: 421 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG 480
Query: 481 VAFGHHAKFIASTGMDRSLKFYSL 504
VAFGHHAKFIASTGMDRSLKFYSL
Sbjct: 481 VAFGHHAKFIASTGMDRSLKFYSL 504
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 117 bits (292), Expect = 3e-26
Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 7/270 (2%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
+T ++ +G D ++V+ + GH VT V F PS L+ S S D T+RIW
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88
Query: 293 VPNASCVQVV-RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
VPN V RAH + V + + G +++SDD+ + L ++ +
Sbjct: 89 VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW- 147
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
+ CA+F PDG + + + D +K+WD R V ++ H G +T + F +G +A A
Sbjct: 148 -VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHF 471
D++VK+WD+R + + QL ++ V L F SG YL +D + I L +
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
Query: 472 T--EHSGLTTGVAFGHHAKFIASTGMDRSL 499
T H G T VAF ++ AS G D +
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Score = 100 bits (249), Expect = 3e-21
Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD +T DK V V+ ++ L +L H V F P L+ SAS D T+++W
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
+ CV H VT + H +G + ++ D D++T R+L +
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 230
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++ FHP G T + DS +KI DL E + GH GP T++AFS G Y A+
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 412 DDSSVKLW 419
D V +W
Sbjct: 291 SDEQVMVW 298
Score = 84.7 bits (208), Expect = 2e-16
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 6/161 (3%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D I++ DK V ++DKSS + + + H VT V FHPS + +A D T+++W
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +Q + H +AV GLS H +G+YL+++S D D+ GR+L +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG--P 273
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIW----DLKERTNVANFP 389
T F G F +G D Q+ +W D+ + V P
Sbjct: 274 ATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVP 314
Score = 63.2 bits (152), Expect = 5e-10
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 3/153 (1%)
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++TC F + +G+MDS + +W +K ++ F GH +T + FS +G+ LA+ +
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEIL 469
D +V++W + +K T+ + V+S+ F G D V+++ + +
Sbjct: 81 RDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLF 139
Query: 470 HFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
++H F + I S D+++K +
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446
+F GH +T + FS N LA+ + DS + +W ++ + V + F S
Sbjct: 14 HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPS 72
Query: 447 GTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503
G LA G D V+I++ E F H+ V F + + D+++K ++
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 117 bits (292), Expect = 3e-26
Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 7/270 (2%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
+T ++ +G D ++V+ + GH VT V F PS L+ S S D T+RIW
Sbjct: 30 NTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88
Query: 293 VPNASCVQVV-RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
VPN V RAH + V + + G +++SDD+ + L ++ +
Sbjct: 89 VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW- 147
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
+ CA+F PDG + + + D +K+WD R V ++ H G +T + F +G +A A
Sbjct: 148 -VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHF 471
D++VK+WD+R + + QL ++ V L F SG YL +D + I L +
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
Query: 472 T--EHSGLTTGVAFGHHAKFIASTGMDRSL 499
T H G T VAF ++ AS G D +
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Score = 100 bits (249), Expect = 3e-21
Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD +T DK V V+ ++ L +L H V F P L+ SAS D T+++W
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
+ CV H VT + H +G + ++ D D++T R+L +
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 230
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++ FHP G T + DS +KI DL E + GH GP T++AFS G Y A+
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 412 DDSSVKLW 419
D V +W
Sbjct: 291 SDEQVMVW 298
Score = 84.7 bits (208), Expect = 2e-16
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 6/161 (3%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D I++ DK V ++DKSS + + + H VT V FHPS + +A D T+++W
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +Q + H +AV GLS H +G+YL+++S D D+ GR+L +
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG--P 273
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIW----DLKERTNVANFP 389
T F G F +G D Q+ +W D+ + V P
Sbjct: 274 ATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVP 314
Score = 63.2 bits (152), Expect = 5e-10
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 3/153 (1%)
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++TC F + +G+MDS + +W +K ++ F GH +T + FS +G+ LA+ +
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEIL 469
D +V++W + +K T+ + V+S+ F G D V+++ + +
Sbjct: 81 RDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLF 139
Query: 470 HFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
++H F + I S D+++K +
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446
+F GH +T + FS N LA+ + DS + +W ++ + V + F S
Sbjct: 14 HFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPS 72
Query: 447 GTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503
G LA G D V+I++ E F H+ V F + + D+++K ++
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 116 bits (290), Expect = 5e-26
Identities = 63/238 (26%), Positives = 117/238 (49%), Gaps = 3/238 (1%)
Query: 219 ASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDL 278
A + +L L + + TGG D V ++ + + +L GHT V SV + ++L
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 279 VFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTG 338
+ + S +IR+W + A ++ + H++ + L H G+++ S S D DI+
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 339 RVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSI 398
+ + + ++ C +F PDG + D +K+WDL ++ FPGH+GP+ +
Sbjct: 138 GCVFRYRGHSQ--AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
Query: 399 AFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
F N Y LA+ + D +++ WDL K + ++ + V+S++F+ G L G D
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG-PVRSVLFNPDGCCLYSGCQD 252
Score = 103 bits (258), Expect = 3e-22
Identities = 54/178 (30%), Positives = 90/178 (50%), Gaps = 2/178 (1%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
I+ G ++ V+D + +IL TL GH + S+ FHP + V S S D I++W +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
CV R H AV L G +L S++DD D+ G+++++ T +
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG--PVNVV 195
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
+FHP+ + +G+ D I+ WDL++ V+ G GP+ S+ F+ +G L + DS
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
Score = 94.4 bits (233), Expect = 2e-19
Identities = 51/167 (30%), Positives = 89/167 (53%), Gaps = 5/167 (2%)
Query: 257 LATLKGHTKKVTSVVF-HPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315
L + H V+S+V S L+ + D + +WS+ +C+ + H S V + L+
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 316 ATGDYLLSSSDDQYWAFSDIQTGRVL-TKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQI 374
+ +++ S D++ ++L T + + + CSL FHP G +G+ D+ I
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSL---DFHPYGEFVASGSQDTNI 129
Query: 375 KIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421
K+WD++ + V + GHS + + FS +G +LA+AADD +VKLWDL
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Score = 72.8 bits (177), Expect = 7e-13
Identities = 62/229 (27%), Positives = 101/229 (44%), Gaps = 18/229 (7%)
Query: 282 ASPDATIRIWSVPNASCVQVVRAHESAVTGLSL-HATGDYLLSSSDD---QYWAFSDIQT 337
A+P T W + Q + AH S V+ L L A+G L + DD W+ +
Sbjct: 2 ATPVVTKTAWKL------QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNC 55
Query: 338 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS 397
LT T L P+ LI G+ I++WDL+ + GH I S
Sbjct: 56 IMSLTGHTSPVESVRLNT----PEELIVA-GSQSGSIRVWDLEAAKILRTLMGHKANICS 110
Query: 398 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD- 456
+ F G ++A+ + D+++KLWD+R+ K ++ V+ L F G +LA D
Sbjct: 111 LDFHPYGEFVASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
Query: 457 -VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
V+++ + F H+G V F + +AS DR+++F+ L
Sbjct: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 114 bits (286), Expect = 2e-25
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 12/257 (4%)
Query: 256 ILATLKGHTKKVTSVVFHPSQDL--------VFSASPDATIRIWSVPNASCVQVVRAHES 307
+L TL+GH V ++VFHP + + S + D ++++WS+ + V + H
Sbjct: 265 LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTV 324
Query: 308 AVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGT 367
V + H +G +L ++ D+ W D++ + + G + FH DG + GT
Sbjct: 325 RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG--VYDIAFHQDGSLAGT 382
Query: 368 GTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNF 427
G +D+ ++WDL+ + GH I I FS NGY++AT + D++ K+WDLR+ +
Sbjct: 383 GGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCV 442
Query: 428 KTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGH 485
T+ N G +L G D +I+ W+ + H G G+
Sbjct: 443 YTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS 502
Query: 486 HAKFIASTGMDRSLKFY 502
+ IA+ DR+ K +
Sbjct: 503 DGQLIATCSYDRTFKLW 519
Score = 90.1 bits (222), Expect = 4e-18
Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 4/205 (1%)
Query: 227 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDA 286
+ L P D N + + AD +V ++ S++ +A ++GHT +V V++HPS + + D
Sbjct: 287 VSLDPKDVN-LASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345
Query: 287 TIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTD 346
+ R+W + + H V ++ H G + D + D++TGR + +
Sbjct: 346 SWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG 405
Query: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE-NGY 405
+ F P+G TG+ D+ K+WDL++R V P H +T + F +G
Sbjct: 406 HLK--EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
Query: 406 YLATAADDSSVKLWDLRKLKNFKTL 430
+L T A D++ K+W KTL
Sbjct: 464 FLLTGAYDNTAKIWTHPGWSPLKTL 488
Score = 63.2 bits (152), Expect = 5e-10
Identities = 43/182 (23%), Positives = 72/182 (39%), Gaps = 45/182 (24%)
Query: 239 TGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASC 298
TGG D V+D + + + L+GH K++ + F P+ + + S D T ++W + C
Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
Query: 299 VQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQ 357
V + AH++ VTG+ G++LL
Sbjct: 442 VYTIPAHQNLVTGVKFEPIHGNFLL----------------------------------- 466
Query: 358 FHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVK 417
TG D+ KIW + + GH G + + S +G +AT + D + K
Sbjct: 467 ---------TGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517
Query: 418 LW 419
LW
Sbjct: 518 LW 519
Score = 33.5 bits (75), Expect = 0.46
Identities = 18/61 (29%), Positives = 26/61 (42%)
Query: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
P N +LTG D ++ L TL GH KV + L+ + S D T ++
Sbjct: 459 PIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 518
Query: 291 W 291
W
Sbjct: 519 W 519
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 111 bits (278), Expect = 1e-24
Identities = 79/260 (30%), Positives = 123/260 (47%), Gaps = 7/260 (2%)
Query: 243 DKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVV 302
D ++V+ + GH VT V F PS L+ S S D T+RIW VPN V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
Query: 303 -RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD 361
RAH + V + + G +++SDD+ + L ++ + + CA+F PD
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW--VRCAKFSPD 118
Query: 362 GLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421
G + + + D +K+WD R V ++ H G +T + F +G +A A D++VK+WD+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 422 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFT--EHSGLTT 479
R + + QL ++ V L F SG YL +D + I L +T H G T
Sbjct: 179 RTHRLLQHYQL-HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 480 GVAFGHHAKFIASTGMDRSL 499
VAF ++ AS G D +
Sbjct: 238 TVAFSRTGEYFASGGSDEQV 257
Score = 100 bits (249), Expect = 3e-21
Identities = 58/188 (30%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD +T DK V V+ ++ L +L H V F P L+ SAS D T+++W
Sbjct: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
+ CV H VT + H +G + ++ D D++T R+L +
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--QLHSA 192
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++ FHP G T + DS +KI DL E + GH GP T++AFS G Y A+
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 412 DDSSVKLW 419
D V +W
Sbjct: 253 SDEQVMVW 260
Score = 97.1 bits (240), Expect = 3e-20
Identities = 60/242 (24%), Positives = 111/242 (45%), Gaps = 6/242 (2%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+ +G DK V ++ + + + HT V SV F +AS D T+++W+
Sbjct: 38 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 97
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
+ + H + V G ++S+SDD+ D + + + G +T
Sbjct: 98 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH--GGFVTYV 155
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416
FHP G MD+ +K+WD++ + ++ HS + ++F +G YL TA+ DS++
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
Query: 417 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSG 476
K+ DL + + TL + ++ F ++G Y A GG+D Q+ + W +H
Sbjct: 216 KILDLMEGRLLYTLH-GHQGPATTVAFSRTGEYFASGGSDEQVMV---WKSNFDIVDHGE 271
Query: 477 LT 478
+T
Sbjct: 272 VT 273
Score = 84.7 bits (208), Expect = 2e-16
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 6/161 (3%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D I++ DK V ++DKSS + + + H VT V FHPS + +A D T+++W
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +Q + H +AV GLS H +G+YL+++S D D+ GR+L +
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG--P 235
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIW----DLKERTNVANFP 389
T F G F +G D Q+ +W D+ + V P
Sbjct: 236 ATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVP 276
Score = 72.0 bits (175), Expect = 1e-12
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 3/155 (1%)
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
++TC F P G + +G+ D ++IW + F H+ + S+ F +G TA+
Sbjct: 25 AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84
Query: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYIC-KQWTEILH 470
DD +VK+W + K +L N+ V+ F G + D + + K E +H
Sbjct: 85 DDKTVKVWATHRQKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 143
Query: 471 -FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+ EH G T V F IA+ GMD ++K + +
Sbjct: 144 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/135 (22%), Positives = 63/135 (46%), Gaps = 3/135 (2%)
Query: 370 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKT 429
MDS + +W +K ++ F GH +T + FS +G+ LA+ + D +V++W + +K T
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGEST 59
Query: 430 LQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHA 487
+ + V+S+ F G D V+++ + + ++H F
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 488 KFIASTGMDRSLKFY 502
+ I S D+++K +
Sbjct: 120 RLIVSASDDKTVKLW 134
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 108 bits (271), Expect = 9e-24
Identities = 72/271 (26%), Positives = 122/271 (45%), Gaps = 7/271 (2%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
+KI TG DK ++ + + T +GHT ++ + F+P LV + S D T ++W +
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS-L 353
N V +R H + + LS + +GD +++ S D D TGR KV C+ +
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR---KVNILIGHCAEI 264
Query: 354 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADD 413
+ A F+ D + TG+MD K+WD VA GH I F G +ATA+ D
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Query: 414 SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWT-EILHFT 472
+ +++ K L+ + E+ + F+ G +L G +D I T + L
Sbjct: 325 GTARIFSAATRKCIAKLE-GHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 383
Query: 473 E-HSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
E H+ AF + + + D + + +
Sbjct: 384 EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 94.0 bits (232), Expect = 3e-19
Identities = 81/350 (23%), Positives = 150/350 (42%), Gaps = 17/350 (4%)
Query: 160 MDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSA 219
+DLG ++ +++++Q +LT R ++ K + + L + K Q ++H +
Sbjct: 33 LDLGPSTDVSA-LVEEIQKAEPLLTASRTEQVKLLIQRLQE-----KLGQNSNHT-FYLF 85
Query: 220 SIPGILALDLCPSDTNK----ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFH-P 274
+ L L NK +TG D+ ++D +S + L TL+GH V ++ F+ P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 275 SQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSD 334
D + + S D T ++WSV C R H + + LS + + + S D D
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 335 IQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP 394
IQ G + + ++ + F+ G TG+ D + +WD V GH
Sbjct: 206 IQNGEEVYTLRGHSA--EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGG 454
I+S +F+ + + T + D + KLWD K TL ++ E+ FD +G +A
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL-TGHDDEILDSCFDYTGKLIATAS 322
Query: 455 TD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
D +I+ I H G + ++F + + D++ + +
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 82.0 bits (201), Expect = 1e-15
Identities = 49/148 (33%), Positives = 78/148 (52%), Gaps = 8/148 (5%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D + ILTG DK ++D ++ + +ATL GH ++ F + L+ +AS D T RI+S
Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTG---RVLTKVTDETS 349
C+ + HE ++ +S + G++LL+ S D+ D QTG +VL TDE
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIF 391
Query: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIW 377
C+ F+ G I TG+ D+ +IW
Sbjct: 392 SCA-----FNYKGNIVITGSKDNTCRIW 414
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 108 bits (270), Expect = 1e-23
Identities = 72/241 (29%), Positives = 107/241 (44%), Gaps = 12/241 (4%)
Query: 248 VFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHES 307
+ D+ + L L GH+ V F P ++ + S+S D T+R+WS+ +C+ + H
Sbjct: 527 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY 586
Query: 308 AVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLI 364
V G Y +S D+ WA Q R+ + + C +FHP+
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN-----CTRFHPNSNY 641
Query: 365 FGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKL 424
TG+ D +++WD+ V F GH GPI S+ FS NG +LAT A D V LWD+
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Query: 425 KNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFG 484
L+ + V SL F + G LA G D + + W I F + A G
Sbjct: 702 LMVGELK-GHTDTVCSLRFSRDGEILASGSMDNTV---RLWDAIKAFEDLETDDFTTATG 757
Query: 485 H 485
H
Sbjct: 758 H 758
Score = 85.9 bits (211), Expect = 8e-17
Identities = 66/285 (23%), Positives = 122/285 (42%), Gaps = 18/285 (6%)
Query: 152 SVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVA 211
S++ G + +TP+ ++ ++ + + + K V E ++ + S+ + +
Sbjct: 483 SLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLID--KESDDVLERIMDEKTASELKILY 540
Query: 212 SHVG-LHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSV 270
H G ++ AS D N +L+ D V ++ + L KGH V
Sbjct: 541 GHSGPVYGASFS---------PDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591
Query: 271 VFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYW 330
F P S D R+W+ + +++ H + V H +Y+ + S D+
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 331 AFSDIQTGRVLTKVTDETSGC-SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP 389
D+ G + T SLT F P+G TG D ++ +WD+ V
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLT---FSPNGRFLATGATDGRVLLWDIGHGLMVGELK 708
Query: 390 GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434
GH+ + S+ FS +G LA+ + D++V+LWD +K F+ L+ D+
Sbjct: 709 GHTDTVCSLRFSRDGEILASGSMDNTVRLWD--AIKAFEDLETDD 751
Score = 52.0 bits (123), Expect = 1e-06
Identities = 33/135 (24%), Positives = 64/135 (47%), Gaps = 9/135 (6%)
Query: 375 KIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRK---LKNFKTLQ 431
+I D K + + GHSGP+ +FS + YL ++++D +V+LW L+ L +K
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK--- 582
Query: 432 LDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKF 489
+N+ V F G Y GG D +++ + + F H F ++ +
Sbjct: 583 -GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
Query: 490 IASTGMDRSLKFYSL 504
+A+ DR+++ + +
Sbjct: 642 VATGSADRTVRLWDV 656
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 107 bits (268), Expect = 2e-23
Identities = 54/198 (27%), Positives = 105/198 (53%), Gaps = 2/198 (1%)
Query: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ ++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 378
+ L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ D ++IWD
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 379 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 438
+K + P HS P++++ F+ +G + +++ D ++WD + KTL D+N V
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 439 KSLIFDQSGTYLALGGTD 456
+ F +G Y+ D
Sbjct: 218 SFVKFSPNGKYILAATLD 235
Score = 101 bits (252), Expect = 1e-21
Identities = 56/203 (27%), Positives = 106/203 (52%), Gaps = 4/203 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S S D ++RIW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
V C++ + AH V+ + + G ++SSS D D +G+ L + D+ +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP- 215
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS---ENGYYLA 408
++ +F P+G T+D+ +K+WD + + + GH I + G ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 409 TAADDSSVKLWDLRKLKNFKTLQ 431
+ ++D+ V +W+L+ + + LQ
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQ 298
Score = 94.0 bits (232), Expect = 3e-19
Identities = 66/275 (24%), Positives = 125/275 (45%), Gaps = 13/275 (4%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+ + ADK + ++ + T+ GH ++ V + +L+ SAS D T++IW V +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C++ ++ H + V + + + ++S S D+ D++TG+ L + + ++
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--PVSAV 177
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVAN-FPGHSGPITSIAFSENGYYLATAADDSS 415
F+ DG + + + D +IWD + + P++ + FS NG Y+ A D++
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 416 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ----SGTYLALGGTDVQIYICKQWTE--IL 469
+KLWD K K KT N K IF G ++ G D +YI T+ +
Sbjct: 238 LKLWDYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Query: 470 HFTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 502
H+ + A IAS + D+++K +
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 107 bits (268), Expect = 2e-23
Identities = 54/198 (27%), Positives = 105/198 (53%), Gaps = 2/198 (1%)
Query: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ ++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 378
+ L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ D ++IWD
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 379 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 438
+K + P HS P++++ F+ +G + +++ D ++WD + KTL D+N V
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
Query: 439 KSLIFDQSGTYLALGGTD 456
+ F +G Y+ D
Sbjct: 218 SFVKFSPNGKYILAATLD 235
Score = 101 bits (252), Expect = 1e-21
Identities = 56/203 (27%), Positives = 106/203 (52%), Gaps = 4/203 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S S D ++RIW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
V C++ + AH V+ + + G ++SSS D D +G+ L + D+ +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP- 215
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS---ENGYYLA 408
++ +F P+G T+D+ +K+WD + + + GH I + G ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 409 TAADDSSVKLWDLRKLKNFKTLQ 431
+ ++D+ V +W+L+ + + LQ
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQ 298
Score = 94.0 bits (232), Expect = 3e-19
Identities = 66/275 (24%), Positives = 125/275 (45%), Gaps = 13/275 (4%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+ + ADK + ++ + T+ GH ++ V + +L+ SAS D T++IW V +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C++ ++ H + V + + + ++S S D+ D++TG+ L + + ++
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--PVSAV 177
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVAN-FPGHSGPITSIAFSENGYYLATAADDSS 415
F+ DG + + + D +IWD + + P++ + FS NG Y+ A D++
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 416 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ----SGTYLALGGTDVQIYICKQWTE--IL 469
+KLWD K K KT N K IF G ++ G D +YI T+ +
Sbjct: 238 LKLWDYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Query: 470 HFTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 502
H+ + A IAS + D+++K +
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 107 bits (267), Expect = 3e-23
Identities = 80/275 (29%), Positives = 127/275 (46%), Gaps = 6/275 (2%)
Query: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283
I +LDL P+ ++ T D +++++ GH VTSV F P +L+ SAS
Sbjct: 21 ITSLDLSPNG-KQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASAS 79
Query: 284 PDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTK 343
D T+R+W +AH + V + A G +L ++S+D+ + R L
Sbjct: 80 RDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 344 VTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSEN 403
+ T + CA+F PDG + + + D IKIWD + V NF G + F+ +
Sbjct: 140 LYRHTHW--VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPS 197
Query: 404 GYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICK 463
G +A+A D +VK+WD+R K + Q+ + V + F SG YL +D + I
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG-GVNCISFHPSGNYLITASSDGTLKILD 256
Query: 464 QWTEILHFT--EHSGLTTGVAFGHHAKFIASTGMD 496
L +T H+G V+F + AS G D
Sbjct: 257 LLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
Score = 95.1 bits (235), Expect = 1e-19
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 2/188 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
+D + T DK++ V+ ++ L +L HT V F P L+ S S D TI+IW
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
N CV + + +G + S+ DQ D++ ++L + G
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGG- 230
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
+ C FHP G T + D +KI DL E + GH+GP+ +++FS+ G A+
Sbjct: 231 -VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
Query: 412 DDSSVKLW 419
D+ V LW
Sbjct: 290 ADTQVLLW 297
Score = 77.8 bits (190), Expect = 2e-14
Identities = 52/207 (25%), Positives = 95/207 (45%), Gaps = 11/207 (5%)
Query: 303 RAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLTKVTDETSGCSLTCAQFH 359
+ H++A+T L L G L ++S D + W F D +T QF
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV-----VTSVQFS 69
Query: 360 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419
P G + + + D +++W +R + F H+ P+ S+ FS +G +LATA++D S+K+W
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 420 DLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTE--ILHFTEHSGL 477
+ + + +L ++ V+ F G + D I I + + +F++ G
Sbjct: 130 SMYRQRFLYSLYRHTHW-VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 478 TTGVAFGHHAKFIASTGMDRSLKFYSL 504
V F IAS G D+++K + +
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDV 215
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/152 (26%), Positives = 72/152 (47%), Gaps = 6/152 (3%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D I++ DK + ++D +++Q + V F+PS + SA D T+++W
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +Q + H V +S H +G+YL+++S D D+ GR++ + T
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG--P 272
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN 384
+ F G +F +G D+Q+ +W RTN
Sbjct: 273 VFTVSFSKGGELFASGGADTQVLLW----RTN 300
Score = 51.2 bits (121), Expect = 2e-06
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 3/119 (2%)
Query: 388 FPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSG 447
F GH ITS+ S NG LATA+ D+ + LW+ + + + V S+ F G
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHAR-AYRYVGHKDVVTSVQFSPHG 72
Query: 448 TYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
LA D V+++I + + F H+ V F +F+A+ D+S+K +S+
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 100 bits (250), Expect = 2e-21
Identities = 54/203 (26%), Positives = 106/203 (52%), Gaps = 4/203 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
SD++++++ DK + ++D S + L TLKGH+ V F+P +L+ S S D T++IW
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
V C++ + AH V+ + + +G ++S S D D +G+ L + D+ +
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP- 211
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS---ENGYYLA 408
++ +F P+G T T+D+ +K+WD + + GH I + G ++
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 409 TAADDSSVKLWDLRKLKNFKTLQ 431
+ ++D+ V +W+L+ + + LQ
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQ 294
Score = 98.2 bits (243), Expect = 2e-20
Identities = 55/219 (25%), Positives = 111/219 (50%), Gaps = 2/219 (0%)
Query: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
L+ A+++ V + + + TL GHT+ V+SV F P+ + + S+S D I IW +
Sbjct: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK 74
Query: 298 CVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQ 357
+ + H ++ ++ + L+S+SDD+ D+++G+ L + ++ + C
Sbjct: 75 YEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN--YVFCCN 132
Query: 358 FHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVK 417
F+P + +G+ D +KIW++K + HS P++++ F+ +G + + + D +
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 418 LWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
+WD + KTL D+N V + F +G Y+ D
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD 231
Score = 90.9 bits (224), Expect = 2e-18
Identities = 62/275 (22%), Positives = 127/275 (46%), Gaps = 13/275 (4%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+ + AD+ ++++ + TL GH +++ V + + SAS D T+++W V +
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C++ ++ H + V + + + ++S S D+ +++TG+ L ++ + ++
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSD--PVSAV 173
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITSIAFSENGYYLATAADDSS 415
F+ G + +G+ D +IWD + + P++ + FS NG Y+ TA D++
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233
Query: 416 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ----SGTYLALGGTDVQIYICKQWTE--IL 469
+KLWD + + KT N K IF G ++ G D +YI T+ +
Sbjct: 234 LKLWDYSRGRCLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 291
Query: 470 HFTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 502
H+ + A IAS + D+++K +
Sbjct: 292 KLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 98.6 bits (244), Expect = 1e-20
Identities = 71/236 (30%), Positives = 114/236 (48%), Gaps = 11/236 (4%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D +LTG D V ++ S Q+L L GHT V F P L SAS D T+R+W
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V A C++V++ H+ +V +S L S D+ D+Q+G++L + S
Sbjct: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD--S 149
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN---FPGHSGPITSIAFSENGYYLAT 409
+ + F P TG+ DS + IWDL+ T + GHS I+ + +S +G LA+
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLAS 208
Query: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFE-VKSLIFDQSGTYLALGGTD--VQIYIC 462
+ D ++ +W + + +QL + VKS+ F +LA G V+++ C
Sbjct: 209 GSWDKTIHIW--KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDC 262
Score = 72.0 bits (175), Expect = 1e-12
Identities = 60/244 (24%), Positives = 97/244 (39%), Gaps = 7/244 (2%)
Query: 263 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 322
H +V S F P ++ + S D + W + + + H V G
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 323 SSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKER 382
S+S D D+ + L + S+ F PD +G D ++ +WD++
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQR--SVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 383 TNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL--DNNFEVKS 440
+ GH I S FS LAT + DS+V +WDLR + + Q ++ +
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
Query: 441 LIFDQSGTYLALGGTDVQIYICKQWTE--ILHFTEHSGLTTGVAFGHHAKFIASTGMDRS 498
L + SG LA G D I+I K T ++ H +AF ++AS G R
Sbjct: 198 LCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
Query: 499 LKFY 502
+K +
Sbjct: 257 VKVW 260
Score = 62.8 bits (151), Expect = 7e-10
Identities = 48/186 (25%), Positives = 83/186 (44%), Gaps = 6/186 (3%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D+ ++ +GG DK V+++D S Q+L L GH + S F P+ + + + S D+T+ IW
Sbjct: 116 DSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Query: 293 ---VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 349
V A Q + H + ++ L A+G L S S D+ T +L ++ +
Sbjct: 176 LRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234
Query: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
+ F PD L + +K+WD + G + AF+ +G L +
Sbjct: 235 W--VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVS 292
Query: 410 AADDSS 415
A D +
Sbjct: 293 GAADQT 298
Score = 49.7 bits (117), Expect = 6e-06
Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 7/128 (5%)
Query: 203 ELSKYRQVASHVGL--HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATL 260
+L SH L HSA+I LC S + + +G DK + ++ ++ +L L
Sbjct: 175 DLRMVTPAVSHQALEGHSANISC-----LCYSASGLLASGSWDKTIHIWKPTTSSLLIQL 229
Query: 261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 320
KGH V S+ F P + + SA +++W C++ ++ + G
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
Query: 321 LLSSSDDQ 328
L+S + DQ
Sbjct: 290 LVSGAADQ 297
Score = 32.7 bits (73), Expect = 0.79
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 3/119 (2%)
Query: 388 FPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSG 447
F H G + S AFS +G L T ++D V W+ R + L + VK F G
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDG 75
Query: 448 TYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
A D V+++ + + H V+F ++ +AS G D+ + + +
Sbjct: 76 HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 97.1 bits (240), Expect = 3e-20
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 9/215 (4%)
Query: 250 DKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAV 309
D ++ + L+GH V S F + S S D +IR W + + + + + H V
Sbjct: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387
Query: 310 TGLSLHATGDYLLSSSDDQ---YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFG 366
L + Y S S D+ W+F R+ + C +FHP+
Sbjct: 388 WDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD-----CVKFHPNSNYLA 442
Query: 367 TGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKN 426
TG+ D +++W ++ +V F GH GP+ S+AFS NG YLA+A +D +KLWDL
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
Query: 427 FKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461
+K L+ + + SL F +A D + +
Sbjct: 503 YKELR-GHTDNITSLTFSPDSGLIASASMDNSVRV 536
Score = 82.0 bits (201), Expect = 1e-15
Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 2/191 (1%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
+D++ +L+ D ++ +D S +GH V + P S S D T R+W
Sbjct: 352 ADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLW 411
Query: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
S +++ H + V + H +YL + S D+ Q G + T G
Sbjct: 412 SFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR-GP 470
Query: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411
L+ A F P+G + D ++K+WDL T GH+ ITS+ FS + +A+A+
Sbjct: 471 VLSLA-FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
Query: 412 DDSSVKLWDLR 422
D+SV++WD+R
Sbjct: 530 MDNSVRVWDIR 540
Score = 78.2 bits (191), Expect = 2e-14
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 2/160 (1%)
Query: 239 TGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASC 298
+G D+ ++ L GH V V FHP+ + + + S D T+R+WS +
Sbjct: 401 SGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNS 460
Query: 299 VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQF 358
V++ H V L+ G YL S+ +DQ D+ +G + ++ T ++T F
Sbjct: 461 VRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD--NITSLTF 518
Query: 359 HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSI 398
PD + + +MD+ +++WD++ A G S + +
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV 558
Score = 76.6 bits (187), Expect = 5e-14
Identities = 73/328 (22%), Positives = 139/328 (42%), Gaps = 51/328 (15%)
Query: 199 VKPEELSKYRQVAS-------HVGLHSASIPGIL-----ALDLCPSDTNKILTGGADKNV 246
V+P + + Y+ AS + GL +P + AL++ ++ G
Sbjct: 199 VQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALEVLQESIKRVKDGPPSLTT 258
Query: 247 VVFDK--SSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRA 304
+ F ++EQ+L T + P L+ + ++ I++WS+ + +++
Sbjct: 259 ICFYAFYNTEQLLNTAE----------ISPDSKLLAAGFDNSCIKLWSLRSKK----LKS 304
Query: 305 HESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGR------VLTKVTDETSGCSLTCAQF 358
V +H D L D+ A ++++ R T+ ++SG L+C++
Sbjct: 305 EPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGL-LSCSE- 362
Query: 359 HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKL 418
D I+ WDL TN + GH+ P+ + S Y A+ + D + +L
Sbjct: 363 ------------DMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARL 410
Query: 419 WDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSG 476
W + + + + +V + F + YLA G TD V+++ +Q + FT H G
Sbjct: 411 WSFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
Query: 477 LTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+AF + K++AS G D+ LK + L
Sbjct: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDL 497
Score = 70.1 bits (170), Expect = 4e-12
Identities = 52/208 (25%), Positives = 87/208 (41%), Gaps = 5/208 (2%)
Query: 299 VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQF 358
++++R H V A LLS S+D + D+ G V + +
Sbjct: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDI 392
Query: 359 HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKL 418
P L F +G+ D ++W + + GH + + F N YLAT + D +V+L
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 419 WDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSG 476
W ++ N L + V SL F +G YLA G D ++++ T H+
Sbjct: 453 WSAQQ-GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511
Query: 477 LTTGVAFGHHAKFIASTGMDRSLKFYSL 504
T + F + IAS MD S++ + +
Sbjct: 512 NITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 54.7 bits (130), Expect = 2e-07
Identities = 29/104 (27%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 209 QVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVT 268
Q + V L + +L+L P+ + + G D+ + ++D +S + L+GHT +T
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNG-KYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 269 SVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGL 312
S+ F P L+ SAS D ++R+W + N C S + G+
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV 558
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/268 (25%), Positives = 115/268 (42%), Gaps = 4/268 (1%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+++ G D+ V +L T GHT ++ FHPS D + ++S D T+++W +
Sbjct: 367 LVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG 426
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C+ H AV + H+ G+++ SSS D+ D+ + R + T S+
Sbjct: 427 DCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTD--SVNSI 484
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416
+F P T + D + IWD + + GH I F G+ +A+
Sbjct: 485 EFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVT 544
Query: 417 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLA-LGGTDVQIYICKQWTEILHFTEHS 475
KLWD RKL ++ + + + FD SG LA G V + + EI H
Sbjct: 545 KLWDFRKLLPIVSIDIGPS-PGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHE 603
Query: 476 GLTTGVAFGHHAKFIASTGMDRSLKFYS 503
V F H + + S G D +++ +S
Sbjct: 604 NEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 82.0 bits (201), Expect = 1e-15
Identities = 56/222 (25%), Positives = 99/222 (44%), Gaps = 4/222 (1%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
+K+ T D V ++D + T +GH++ V S +H + V S+S D T +IW V
Sbjct: 407 DKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVN 466
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
+ C + H +V + + LL+SS D+ + D +TG + S+
Sbjct: 467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH--SIN 524
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
A F P G + + K+WD ++ + + P + F +G LA A+ +
Sbjct: 525 DAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNG 584
Query: 415 SVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
+ L DL+ + K + +N E +++F G L GG+D
Sbjct: 585 VIHLLDLKSGEIHKLMGHEN--EAHTVVFSHDGEILFSGGSD 624
Score = 65.1 bits (157), Expect = 1e-10
Identities = 36/121 (29%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 301 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360
+ R HE V+ +S+ D L+S +D+ W + VL T S C FHP
Sbjct: 347 IFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCC--FHP 404
Query: 361 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
G T + D+ +K+WDL + + F GHS + S + G ++A+++ D + K+WD
Sbjct: 405 SGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Query: 421 L 421
+
Sbjct: 465 V 465
Score = 44.3 bits (103), Expect = 3e-04
Identities = 28/144 (19%), Positives = 59/144 (40%), Gaps = 3/144 (2%)
Query: 234 TNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293
+N +LT ADK + ++D + +L GH + +F P ++ S ++W
Sbjct: 490 SNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDF 549
Query: 294 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSL 353
+ + S ++ ++G L +S + D+++G + + E ++
Sbjct: 550 RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTV 609
Query: 354 TCAQFHPDGLIFGTGTMDSQIKIW 377
F DG I +G D ++ W
Sbjct: 610 V---FSHDGEILFSGGSDGTVRTW 630
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 94.4 bits (233), Expect = 2e-19
Identities = 65/255 (25%), Positives = 117/255 (45%), Gaps = 15/255 (5%)
Query: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ 276
H +++ G++ P + + G DK V +D +++ GH V + HP+
Sbjct: 245 HISTVRGVIVSTRSPY----LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 300
Query: 277 DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQ 336
D++ + S D+T RIW V + V + H +AV + A +++ S D D+
Sbjct: 301 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
Query: 337 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 396
G+ T+VT S+ HP F +G+ D+ IK W + + + N GH+ I
Sbjct: 361 AGK--TRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417
Query: 397 SIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL-------QLDNNFEVKSLIFDQSGTY 449
++ + +G L + AD+ ++ LWD R NF+ + LD+ + + FDQS +
Sbjct: 418 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR 476
Query: 450 LALGGTDVQIYICKQ 464
L D I + ++
Sbjct: 477 LLTAEADKTIKVYRE 491
Score = 72.8 bits (177), Expect = 7e-13
Identities = 93/452 (20%), Positives = 170/452 (37%), Gaps = 85/452 (18%)
Query: 27 RRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVM 86
+R + ++A+NG P+ PL EE K+A +R + +P + L+++
Sbjct: 19 KRTHDMFVADNGK-PV---PLDEESH-KRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNA 73
Query: 87 LHSFTLRQQLQTTRQELSHALYQHD----------AACRVIARLTKEVTAAREALAT--- 133
S+ +Q QE+ + + A I R+ E A A+A
Sbjct: 74 TDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPLQ 133
Query: 134 LKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKT 193
K A P P +P + +V ++ T + K+ T
Sbjct: 134 TKADANRTAPSGSEYRHPGASDRPQPTAMNSIV---------METGNTKNSALMAKKAPT 184
Query: 194 VPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSS 253
+P+ P YR ++ H+G + + + P + +TG AD+ + ++D +S
Sbjct: 185 MPKPQWHPP-WKLYRVISGHLGW-------VRCIAVEPGN-QWFVTGSADRTIKIWDLAS 235
Query: 254 EQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLS 313
++ +L GH V V+ +FS D ++ W + ++ H SAV GL
Sbjct: 236 GKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLD 295
Query: 314 LHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQ 373
LH T D L+ TC++ DS
Sbjct: 296 LHPTIDVLV-------------------------------TCSR-------------DST 311
Query: 374 IKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLD 433
+IWD++ + +V GH+ + ++ + T + D++++LWDL K TL +
Sbjct: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL-TN 370
Query: 434 NNFEVKSLIFDQSGTYLALGGTDVQIYICKQW 465
+ V++++ A G D KQW
Sbjct: 371 HKKSVRAVVLHPRHYTFASGSPD----NIKQW 398
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 92.0 bits (227), Expect = 1e-18
Identities = 48/188 (25%), Positives = 82/188 (43%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D N+I+T D ++D + Q T GHT V S+ P L S + DA+ ++W
Sbjct: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V C Q HES + + G+ + SDD D++ + L + + C
Sbjct: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412
+T F G + G D +WD + GH ++ + +++G +AT +
Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
Query: 413 DSSVKLWD 420
DS +K+W+
Sbjct: 333 DSFLKIWN 340
Score = 80.9 bits (198), Expect = 3e-15
Identities = 68/254 (26%), Positives = 103/254 (40%), Gaps = 53/254 (20%)
Query: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
TL+GH K+ ++ + L+ SAS D + IW + V + S V + +G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 319 DY---------------------------------------------LLSSSDDQYWAFS 333
+Y +++SS D A
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169
Query: 334 DIQTGRVLTKVTDETSG-CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS 392
DI+TG+ T T T SL+ A PD +F +G D+ K+WD++E F GH
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLA---PDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226
Query: 393 GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLA 451
I +I F NG AT +DD++ +L+DLR + T DN + S+ F +SG L
Sbjct: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286
Query: 452 LGGTDVQIYICKQW 465
G D + C W
Sbjct: 287 AGYDD---FNCNVW 297
Score = 65.5 bits (158), Expect = 1e-10
Identities = 57/229 (24%), Positives = 91/229 (39%), Gaps = 12/229 (5%)
Query: 235 NKILTGGADKNVVVFDKSSEQ----ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
N + GG D +++ + + + L GHT ++ F +V S S D T +
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCAL 168
Query: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350
W + H V LSL +S + D D++ G T S
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG---PITSIAFSENGYYL 407
+ C F P+G F TG+ D+ +++DL+ + + H ITS++FS++G L
Sbjct: 229 INAIC--FFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLL 285
Query: 408 ATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
DD + +WD K L +N V L G +A G D
Sbjct: 286 LAGYDDFNCNVWDALKADRAGVLAGHDN-RVSCLGVTDDGMAVATGSWD 333
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 90.9 bits (224), Expect = 2e-18
Identities = 48/188 (25%), Positives = 83/188 (44%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D N I+T D ++D + Q GHT S+ P +L S + DA+ ++W
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +C Q HES + + G+ + + SDD D++ + L + E+ C
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICG 272
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412
+T F G + G D +WD + V GH ++ + + +G +AT +
Sbjct: 273 ITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSW 332
Query: 413 DSSVKLWD 420
DS +K+W+
Sbjct: 333 DSFLKIWN 340
Score = 79.0 bits (193), Expect = 1e-14
Identities = 64/253 (25%), Positives = 111/253 (43%), Gaps = 11/253 (4%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
+D+ +++ D ++V+D + + + + V + + PS + V D I+
Sbjct: 65 TDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIY 124
Query: 292 SVPNASCVQVVRAHESAVTGL---SLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348
++ + V SA TG + +++SS D A DI+TG+ T T
Sbjct: 125 NLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHT 184
Query: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 408
C PD +F +G D+ K+WD++E T F GH I +I F NG +
Sbjct: 185 GDCMSLAVS--PDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAIC 242
Query: 409 TAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLALGGTDVQIYICKQWTE 467
T +DD+S +L+DLR + ++ + S+ F SG L G D + C W
Sbjct: 243 TGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDD---FNCNVWDS 299
Query: 468 ILHFTEHSGLTTG 480
+ +E G+ +G
Sbjct: 300 MK--SERVGILSG 310
Score = 60.1 bits (144), Expect = 5e-09
Identities = 56/228 (24%), Positives = 91/228 (39%), Gaps = 10/228 (4%)
Query: 235 NKILTGGADKNVVVFDKSSEQ----ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
N + GG D +++ S + + L HT ++ F ++V S S D T +
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCAL 168
Query: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350
W + V H L++ + +S + D D++ G T S
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS--GPITSIAFSENGYYLA 408
+ C F P+G TG+ D+ +++DL+ + F S ITS+AFS +G L
Sbjct: 229 INAIC--FFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLF 286
Query: 409 TAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
DD + +WD K + L +N V L G +A G D
Sbjct: 287 AGYDDFNCNVWDSMKSERVGILSGHDN-RVSCLGVTADGMAVATGSWD 333
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 89.4 bits (220), Expect = 7e-18
Identities = 68/292 (23%), Positives = 133/292 (45%), Gaps = 24/292 (8%)
Query: 177 QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNK 236
Q + +T +R+K+GK E+ + + + +++ + G IP + ++L
Sbjct: 213 QKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNL------- 265
Query: 237 ILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV 293
++ + +K ++ + GHTK V++V P S L+ S S D I++W V
Sbjct: 266 -------RSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV 318
Query: 294 -PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
C++ H AV + + G LS++ D+Y D +TG+ +++ T+
Sbjct: 319 YGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY- 377
Query: 353 LTCAQFHPDG---LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
C +F+PD +F G D +I WD++ V + H G + +I F + +
Sbjct: 378 --CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVS 435
Query: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461
+DD S+++W+ +FK + + + ++ +G +LA D QI I
Sbjct: 436 TSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILI 487
Score = 46.2 bits (108), Expect = 7e-05
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 7/192 (3%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS-- 292
N + G +DK +V +D S +I+ H V ++VF S S D ++R+W
Sbjct: 389 NLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD 448
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSS-DDQYWAFSDIQTGRV-LTKVTDETSG 350
+P + ++ ++L G +L S D+Q F R+ K+
Sbjct: 449 IP-VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMV 507
Query: 351 CSLTC-AQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP-ITSIAFSENGYYLA 408
C F PD +G + ++ IWD K + F H I ++ +
Sbjct: 508 AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVI 567
Query: 409 TAADDSSVKLWD 420
T D +KLWD
Sbjct: 568 TCGWDGLIKLWD 579
Score = 30.4 bits (67), Expect = 3.9
Identities = 15/66 (22%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 227 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPD 285
+D P D + +++G + + ++D + ++ + K H K V+HP + V + D
Sbjct: 514 VDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWD 572
Query: 286 ATIRIW 291
I++W
Sbjct: 573 GLIKLW 578
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/274 (24%), Positives = 126/274 (45%), Gaps = 18/274 (6%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N+I++G D + V+ + + L TL GHT V S +++ S S D T+++W+
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAE 331
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
C+ + H S V + LH ++S S D DI+TG+ L + + ++
Sbjct: 332 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVA--AVR 387
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
C Q+ DG +G D +K+WD + T + GH+ + S+ F +G ++ + + D+
Sbjct: 388 CVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 443
Query: 415 SVKLWDLRKLKNFKTL----QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILH 470
S+++WD+ TL L + E+K I + D++ C Q +
Sbjct: 444 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ--TLQG 501
Query: 471 FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+H T + F + F+ ++ D ++K + L
Sbjct: 502 PNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDL 533
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 52/241 (21%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N I++G D+ + V++ + + + TL GHT V + H + V S S DAT+R+W +
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIE 371
Query: 295 NASCVQVVRAHESAVTGL--------------------------------------SLHA 316
C+ V+ H +AV + SL
Sbjct: 372 TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 431
Query: 317 TGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKI 376
G +++S S D D++TG + +T SLT D ++ +G DS +KI
Sbjct: 432 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ---SLTSGMELKDNILV-SGNADSTVKI 487
Query: 377 WDLKERTNVANFPG---HSGPITSIAFSENGYYLATAADDSSVKLWDLRK---LKNFKTL 430
WD+K + G H +T + F++N ++ T++DD +VKLWDL+ ++N TL
Sbjct: 488 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTL 545
Query: 431 Q 431
+
Sbjct: 546 E 546
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 7/156 (4%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D ++++G D V V+D +E L TL+GHT +V S+ F V S S D +IR+W
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD 449
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +C+ + H+S +G+ L + L+S + D DI+TG+ L + S
Sbjct: 450 VETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 507
Query: 353 -LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN 387
+TC QF+ + +I T + D +K+WDLK + N
Sbjct: 508 AVTCLQFNKNFVI--TSSDDGTVKLWDLKTGEFIRN 541
Score = 68.6 bits (166), Expect = 1e-11
Identities = 61/247 (24%), Positives = 110/247 (44%), Gaps = 16/247 (6%)
Query: 260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
LKGH V + + +V S S D T+++WS C++ + H V S +
Sbjct: 258 LKGHDDHVITCLQFCGNRIV-SGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 314
Query: 320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL 379
++S S D+ + +TG + + TS ++ C H ++ +G+ D+ +++WD+
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVV--SGSRDATLRVWDI 370
Query: 380 KERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVK 439
+ + GH + + + +G + + A D VK+WD TLQ N V
Sbjct: 371 ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN-RVY 427
Query: 440 SLIFDQSGTYLALGGTDVQIYICKQWT-EILH-FTEHSGLTTGVAFGHHAKFIASTGMDR 497
SL FD G ++ G D I + T +H T H LT+G+ + + S D
Sbjct: 428 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADS 483
Query: 498 SLKFYSL 504
++K + +
Sbjct: 484 TVKIWDI 490
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/274 (24%), Positives = 126/274 (45%), Gaps = 18/274 (6%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N+I++G D + V+ + + L TL GHT V S +++ S S D T+++W+
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAE 449
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
C+ + H S V + LH ++S S D DI+TG+ L + + ++
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVA--AVR 505
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
C Q+ DG +G D +K+WD + T + GH+ + S+ F +G ++ + + D+
Sbjct: 506 CVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
Query: 415 SVKLWDLRKLKNFKTL----QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILH 470
S+++WD+ TL L + E+K I + D++ C Q +
Sbjct: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ--TLQG 619
Query: 471 FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+H T + F + F+ ++ D ++K + L
Sbjct: 620 PNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDL 651
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 52/241 (21%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N I++G D+ + V++ + + + TL GHT V + H + V S S DAT+R+W +
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIE 489
Query: 295 NASCVQVVRAHESAVTGL--------------------------------------SLHA 316
C+ V+ H +AV + SL
Sbjct: 490 TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 317 TGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKI 376
G +++S S D D++TG + +T SLT D ++ +G DS +KI
Sbjct: 550 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ---SLTSGMELKDNILV-SGNADSTVKI 605
Query: 377 WDLKERTNVANFPG---HSGPITSIAFSENGYYLATAADDSSVKLWDLRK---LKNFKTL 430
WD+K + G H +T + F++N ++ T++DD +VKLWDL+ ++N TL
Sbjct: 606 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTL 663
Query: 431 Q 431
+
Sbjct: 664 E 664
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 7/156 (4%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D ++++G D V V+D +E L TL+GHT +V S+ F V S S D +IR+W
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD 567
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +C+ + H+S +G+ L + L+S + D DI+TG+ L + S
Sbjct: 568 VETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 353 -LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN 387
+TC QF+ + +I T + D +K+WDLK + N
Sbjct: 626 AVTCLQFNKNFVI--TSSDDGTVKLWDLKTGEFIRN 659
Score = 68.6 bits (166), Expect = 1e-11
Identities = 61/247 (24%), Positives = 110/247 (44%), Gaps = 16/247 (6%)
Query: 260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
LKGH V + + +V S S D T+++WS C++ + H V S +
Sbjct: 376 LKGHDDHVITCLQFCGNRIV-SGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 432
Query: 320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL 379
++S S D+ + +TG + + TS ++ C H ++ +G+ D+ +++WD+
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVV--SGSRDATLRVWDI 488
Query: 380 KERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVK 439
+ + GH + + + +G + + A D VK+WD TLQ N V
Sbjct: 489 ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN-RVY 545
Query: 440 SLIFDQSGTYLALGGTDVQIYICKQWT-EILH-FTEHSGLTTGVAFGHHAKFIASTGMDR 497
SL FD G ++ G D I + T +H T H LT+G+ + + S D
Sbjct: 546 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADS 601
Query: 498 SLKFYSL 504
++K + +
Sbjct: 602 TVKIWDI 608
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/274 (24%), Positives = 126/274 (45%), Gaps = 18/274 (6%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N+I++G D + V+ + + L TL GHT V S +++ S S D T+++W+
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAE 369
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
C+ + H S V + LH ++S S D DI+TG+ L + + ++
Sbjct: 370 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVA--AVR 425
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
C Q+ DG +G D +K+WD + T + GH+ + S+ F +G ++ + + D+
Sbjct: 426 CVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 481
Query: 415 SVKLWDLRKLKNFKTL----QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILH 470
S+++WD+ TL L + E+K I + D++ C Q +
Sbjct: 482 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ--TLQG 539
Query: 471 FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+H T + F + F+ ++ D ++K + L
Sbjct: 540 PNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDL 571
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 52/241 (21%)
Query: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
N I++G D+ + V++ + + + TL GHT V + H + V S S DAT+R+W +
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIE 409
Query: 295 NASCVQVVRAHESAVTGL--------------------------------------SLHA 316
C+ V+ H +AV + SL
Sbjct: 410 TGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 317 TGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKI 376
G +++S S D D++TG + +T SLT D ++ +G DS +KI
Sbjct: 470 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ---SLTSGMELKDNILV-SGNADSTVKI 525
Query: 377 WDLKERTNVANFPG---HSGPITSIAFSENGYYLATAADDSSVKLWDLRK---LKNFKTL 430
WD+K + G H +T + F++N ++ T++DD +VKLWDL+ ++N TL
Sbjct: 526 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTL 583
Query: 431 Q 431
+
Sbjct: 584 E 584
Score = 80.5 bits (197), Expect = 3e-15
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 7/156 (4%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D ++++G D V V+D +E L TL+GHT +V S+ F V S S D +IR+W
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD 487
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V +C+ + H+S +G+ L + L+S + D DI+TG+ L + S
Sbjct: 488 VETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 545
Query: 353 -LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN 387
+TC QF+ + +I T + D +K+WDLK + N
Sbjct: 546 AVTCLQFNKNFVI--TSSDDGTVKLWDLKTGEFIRN 579
Score = 68.6 bits (166), Expect = 1e-11
Identities = 61/247 (24%), Positives = 110/247 (44%), Gaps = 16/247 (6%)
Query: 260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
LKGH V + + +V S S D T+++WS C++ + H V S +
Sbjct: 296 LKGHDDHVITCLQFCGNRIV-SGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 352
Query: 320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL 379
++S S D+ + +TG + + TS ++ C H ++ +G+ D+ +++WD+
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTS--TVRCMHLHEKRVV--SGSRDATLRVWDI 408
Query: 380 KERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVK 439
+ + GH + + + +G + + A D VK+WD TLQ N V
Sbjct: 409 ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN-RVY 465
Query: 440 SLIFDQSGTYLALGGTDVQIYICKQWT-EILH-FTEHSGLTTGVAFGHHAKFIASTGMDR 497
SL FD G ++ G D I + T +H T H LT+G+ + + S D
Sbjct: 466 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADS 521
Query: 498 SLKFYSL 504
++K + +
Sbjct: 522 TVKIWDI 528
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 87.8 bits (216), Expect = 2e-17
Identities = 69/253 (27%), Positives = 118/253 (46%), Gaps = 15/253 (5%)
Query: 258 ATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT 317
ATLKGH+ V + ++ ++FSAS D T+ +W V+ ++ H S V
Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARR 162
Query: 318 GDYLL-SSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKI 376
G L+ + SDD DI+ + + ++T F+ +G +D+ IK+
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVT---FNDTSDQIISGGIDNDIKV 219
Query: 377 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLR----KLKNFKTLQL 432
WDL++ GH+ +T ++ S G YL + A D++V++WD+R K + K Q
Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279
Query: 433 D-NNFEVKSLI---FDQSGTYLALGGTDVQIYICKQWTE--ILHFTEHSGLTTGVAFGHH 486
+ +NFE K+L+ + G+ +A G D +Y+ + + H+G VAF
Sbjct: 280 NVHNFE-KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Query: 487 AKFIASTGMDRSL 499
I S D+ L
Sbjct: 339 EPIIISASSDKRL 351
Score = 80.5 bits (197), Expect = 3e-15
Identities = 49/192 (25%), Positives = 89/192 (46%), Gaps = 7/192 (3%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+ TG D V ++D + + T + +T +V +V F+ + D + S D I++W +
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC----- 351
+R H +VTGLSL + G YLLS++ D D++ + G
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 352 -SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATA 410
+L + PDG G+ D + +WD R + PGH+G I +AF + + +A
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 411 ADDSSVKLWDLR 422
+ D + + +++
Sbjct: 346 SSDKRLYMGEIQ 357
Score = 69.7 bits (169), Expect = 6e-12
Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 6/209 (2%)
Query: 299 VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQF 358
+ ++ HE V H G L S+ D+ ++ G T + ++ +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHY 117
Query: 359 HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA-TAADDSSVK 417
+ DG + + + D + +WD + V GH+ + S + G L T +DD +VK
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 418 LWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTE--HS 475
LWD+RK +T Q N ++V ++ F+ + + GG D I + L +T H+
Sbjct: 178 LWDIRKKAAIQTFQ--NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
Query: 476 GLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
TG++ ++ S MD +++ + +
Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/53 (43%), Positives = 32/53 (60%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPD 285
D +KI G AD+ V V+D +S +IL L GH + V FHP + ++ SAS D
Sbjct: 296 DGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 87.4 bits (215), Expect = 3e-17
Identities = 62/290 (21%), Positives = 130/290 (44%), Gaps = 29/290 (10%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
+++ D + V+D + TLKGHT V + F S L+ S S D TI++W
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C++ + H+ V+ +++ GD+++S+S D+ ++QTG + T +
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM--V 240
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS--------------- 401
+ + DG + + + D +++W + + A H + I+++
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
Query: 402 -----ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
+ G +L + + D ++K+WD+ TL +N+ V+ ++F G ++ D
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW-VRGVLFHSGGKFILSCADD 359
Query: 457 ----VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
V Y K+ + L+ EH T + F A ++ + +D+++K +
Sbjct: 360 KTLRVWDYKNKRCMKTLNAHEH--FVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 81.6 bits (200), Expect = 1e-15
Identities = 65/272 (23%), Positives = 115/272 (42%), Gaps = 39/272 (14%)
Query: 260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319
L GH VT V+FHP ++ SAS DATI++W + ++ H +V +S +G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 320 YLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKI 376
L S S D + W F + R + S ++ P+G + + D IK+
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM-----PNGDHIVSASRDKTIKM 218
Query: 377 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW---------DLRKLK-- 425
W+++ V F GH + + +++G +A+ ++D +V++W +LR+ +
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 426 ----------NFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTE-----ILH 470
++ ++ E K + G +L G D I K W ++
Sbjct: 279 VECISWAPESSYSSISEATGSETKK--SGKPGPFLLSGSRDKTI---KMWDVSTGMCLMT 333
Query: 471 FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
H GV F KFI S D++L+ +
Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 75.5 bits (184), Expect = 1e-13
Identities = 55/208 (26%), Positives = 90/208 (43%), Gaps = 26/208 (12%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD--LVFSASPDATIRIWSVP 294
I++ DK + +++ + + T GH + V V P+QD L+ S S D T+R+W V
Sbjct: 207 IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVA 264
Query: 295 NASCVQVVRAHESAVTGLSL----------HATGD----------YLLSSSDDQYWAFSD 334
C +R HE V +S ATG +LLS S D+ D
Sbjct: 265 TKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324
Query: 335 IQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP 394
+ TG L + + + FH G + D +++WD K + + H
Sbjct: 325 VSTGMCLMTLVGHDNW--VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF 382
Query: 395 ITSIAFSENGYYLATAADDSSVKLWDLR 422
+TS+ F + Y+ T + D +VK+W+ R
Sbjct: 383 VTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 59.3 bits (142), Expect = 8e-09
Identities = 42/172 (24%), Positives = 76/172 (44%), Gaps = 9/172 (5%)
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTG---RVLTKVTDETS 349
+P + H S VT + H ++S+S+D D +TG R L TD
Sbjct: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ 154
Query: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
S F G + + + D IK+WD + + GH ++S+A NG ++ +
Sbjct: 155 DIS-----FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVS 209
Query: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461
A+ D ++K+W+++ KT + V+ + +Q GT +A D + +
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREW-VRMVRPNQDGTLIASCSNDQTVRV 260
Score = 43.9 bits (102), Expect = 3e-04
Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 7/119 (5%)
Query: 390 GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTY 449
GH P+T + F + +A++D+++K+WD + +F+ + V+ + FD SG
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 450 LALGGTDVQIYICK----QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
LA D+ I + + +H +H+ + VA + I S D+++K + +
Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHN--VSSVAIMPNGDHIVSASRDKTIKMWEV 221
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 87.4 bits (215), Expect = 3e-17
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 28/226 (12%)
Query: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
++GG D + V++ + L TL GH + + FH + SAS D TIR+W+ + +
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 298 CVQVVRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFSDIQ----------------TG 338
CV V+ H V H T D ++S+S DQ W S ++ TG
Sbjct: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
Query: 339 RVLTKVTD-------ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT--NVANFP 389
L TD E + A FHP + +G D Q+KIW + E V
Sbjct: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
Query: 390 GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNN 435
GH ++ F + + ++D S+++WD+ K +T + D++
Sbjct: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHD 292
Score = 58.9 bits (141), Expect = 1e-08
Identities = 46/217 (21%), Positives = 84/217 (38%), Gaps = 30/217 (13%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
ILT + + ++D ++ H V + FH Q L S D I++W+
Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C+ + H + H ++LS+SDDQ + Q+ + +T + CA
Sbjct: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNH--YVMCA 141
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLK--ERTNVAN--------------------------F 388
QFHP + + ++D +++WD+ + N++
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVL 201
Query: 389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
GH + AF + + ADD VK+W + + K
Sbjct: 202 EGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESK 238
Score = 53.9 bits (128), Expect = 3e-07
Identities = 34/170 (20%), Positives = 71/170 (41%), Gaps = 2/170 (1%)
Query: 256 ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315
+L + + +V + FHP + + ++ + I++W + + H+ V G+ H
Sbjct: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
Query: 316 ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIK 375
+S DD + + R L + T FH + + + D I+
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIR 118
Query: 376 IWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
+W+ + RT V GH+ + F + +A+ D +V++WD+ L+
Sbjct: 119 VWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLR 168
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/192 (23%), Positives = 80/192 (41%), Gaps = 25/192 (13%)
Query: 237 ILTGGADKNVVVF--DKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
I++G D+ V ++ ++S + T +GH V+ VFHP Q+L+ S S D +IR+W +
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMS 279
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
+ VQ R L+ H + + D G ++ K+ E ++
Sbjct: 280 KRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDG----------GMIVFKLERERPAYAVH 329
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG---PITSIAF--SENGYYLAT 409
H D ++ D +VA SG P+ ++++ +EN L T
Sbjct: 330 GNMLH--------YVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCT 381
Query: 410 AADDSSVKLWDL 421
A + +DL
Sbjct: 382 RASNLENSTYDL 393
Score = 47.0 bits (110), Expect = 4e-05
Identities = 34/167 (20%), Positives = 70/167 (41%), Gaps = 5/167 (2%)
Query: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399
+LTK ET + FHP T + I++WD + T + F H GP+ I
Sbjct: 1 MLTKF--ETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
Query: 400 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--V 457
F + + DD +K+W+ + + TL L + +++ F ++ D +
Sbjct: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTL-LGHLDYIRTTFFHHEYPWILSASDDQTI 117
Query: 458 QIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+++ + T + T H+ F + S +D++++ + +
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 87.4 bits (215), Expect = 3e-17
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 28/226 (12%)
Query: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
++GG D + V++ + L TL GH + + FH + SAS D TIR+W+ + +
Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126
Query: 298 CVQVVRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFSDIQ----------------TG 338
CV V+ H V H T D ++S+S DQ W S ++ TG
Sbjct: 127 CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186
Query: 339 RVLTKVTD-------ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT--NVANFP 389
L TD E + A FHP + +G D Q+KIW + E V
Sbjct: 187 VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246
Query: 390 GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNN 435
GH ++ F + + ++D S+++WD+ K +T + D++
Sbjct: 247 GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHD 292
Score = 58.9 bits (141), Expect = 1e-08
Identities = 46/217 (21%), Positives = 84/217 (38%), Gaps = 30/217 (13%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
ILT + + ++D ++ H V + FH Q L S D I++W+
Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLR 83
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
C+ + H + H ++LS+SDDQ + Q+ + +T + CA
Sbjct: 84 RCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNH--YVMCA 141
Query: 357 QFHPDGLIFGTGTMDSQIKIWDLK--ERTNVAN--------------------------F 388
QFHP + + ++D +++WD+ + N++
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVL 201
Query: 389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
GH + AF + + ADD VK+W + + K
Sbjct: 202 EGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESK 238
Score = 53.9 bits (128), Expect = 3e-07
Identities = 34/170 (20%), Positives = 71/170 (41%), Gaps = 2/170 (1%)
Query: 256 ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315
+L + + +V + FHP + + ++ + I++W + + H+ V G+ H
Sbjct: 1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFH 60
Query: 316 ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIK 375
+S DD + + R L + T FH + + + D I+
Sbjct: 61 KQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTF--FHHEYPWILSASDDQTIR 118
Query: 376 IWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425
+W+ + RT V GH+ + F + +A+ D +V++WD+ L+
Sbjct: 119 VWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLR 168
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/192 (23%), Positives = 80/192 (41%), Gaps = 25/192 (13%)
Query: 237 ILTGGADKNVVVF--DKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP 294
I++G D+ V ++ ++S + T +GH V+ VFHP Q+L+ S S D +IR+W +
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMS 279
Query: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354
+ VQ R L+ H + + D G ++ K+ E ++
Sbjct: 280 KRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDG----------GMIVFKLERERPAYAVH 329
Query: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG---PITSIAF--SENGYYLAT 409
H D ++ D +VA SG P+ ++++ +EN L T
Sbjct: 330 GNMLH--------YVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCT 381
Query: 410 AADDSSVKLWDL 421
A + +DL
Sbjct: 382 RASNLENSTYDL 393
Score = 47.0 bits (110), Expect = 4e-05
Identities = 34/167 (20%), Positives = 70/167 (41%), Gaps = 5/167 (2%)
Query: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399
+LTK ET + FHP T + I++WD + T + F H GP+ I
Sbjct: 1 MLTKF--ETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGID 58
Query: 400 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--V 457
F + + DD +K+W+ + + TL L + +++ F ++ D +
Sbjct: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTL-LGHLDYIRTTFFHHEYPWILSASDDQTI 117
Query: 458 QIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
+++ + T + T H+ F + S +D++++ + +
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 86.3 bits (212), Expect = 6e-17
Identities = 47/188 (25%), Positives = 83/188 (44%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D N+I+T D ++D + Q GH+ V S+ P S + DA+I++W
Sbjct: 153 DDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
V ++ C Q HES + ++ G + SDD D++ + L + + C
Sbjct: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICG 272
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412
+T F G + G D IWD + GH ++ + +++G +AT +
Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
Query: 413 DSSVKLWD 420
DS +K+W+
Sbjct: 333 DSFLKIWN 340
Score = 80.1 bits (196), Expect = 4e-15
Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
+D+ +++ D ++++D + + + + V + + PS + V D I+
Sbjct: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIY 124
Query: 292 SVPNASC-VQVVRAHESAVTGLSL--HATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348
S+ V+V R LS + +++SS D A DI+TG+ +
Sbjct: 125 SLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHS 184
Query: 349 SGC-SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYL 407
SL+ A PDG F +G D+ IK+WD+++ F GH I ++AF NGY
Sbjct: 185 GDVMSLSLA---PDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAF 241
Query: 408 ATAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLALGGTDVQIYICKQWT 466
T +DD++ +L+DLR + DN + S+ F +SG L G D + C W
Sbjct: 242 TTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDD---FNCNIWD 298
Query: 467 EILHFTEHSGLTTGVAFGH 485
+ G GV GH
Sbjct: 299 AM------KGDRAGVLAGH 311
Score = 79.7 bits (195), Expect = 6e-15
Identities = 56/238 (23%), Positives = 111/238 (46%), Gaps = 8/238 (3%)
Query: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318
TL+GH K+ ++ + L+ SAS D + IW + V + S V + +G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGLIFGTGTMDSQIKI 376
+++ D + ++T +V+ E G + L+C +F D I T + D+ +
Sbjct: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTCAL 168
Query: 377 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 436
WD++ F GHSG + S++ + +G + A D+S+KLWD+R +T + +
Sbjct: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTF-IGHES 227
Query: 437 EVKSLIFDQSGTYLALGGTDV--QIYICKQWTEILHFTEHSGL--TTGVAFGHHAKFI 490
++ ++ F +G G D +++ + E+L ++ + + T VAF + +
Sbjct: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL 285
Score = 33.5 bits (75), Expect = 0.46
Identities = 25/148 (16%), Positives = 58/148 (39%), Gaps = 4/148 (2%)
Query: 361 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
D + + + D ++ IWD V P S + + A++ +G ++A D+ ++
Sbjct: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYS 125
Query: 421 LR----KLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSG 476
L+ ++ + L + D + + G T ++ + + + F HSG
Sbjct: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSG 185
Query: 477 LTTGVAFGHHAKFIASTGMDRSLKFYSL 504
++ + S D S+K + +
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDV 213
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 84.3 bits (207), Expect = 2e-16
Identities = 66/274 (24%), Positives = 124/274 (45%), Gaps = 7/274 (2%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILA--TLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
++ ++TG D V V+ E++ +L+GH V SV + + S+S DA IR+
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350
W + N ++ + A L+ YL + + +++G+ + + +T G
Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDTRG 148
Query: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATA 410
+ + PDG +G +D I I+D+ + GH+ PI S+ FS + L TA
Sbjct: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
Query: 411 ADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEI 468
+DD +K++D++ TL ++ V ++ F T+ +D V+++ T +
Sbjct: 209 SDDGYIKIYDVQHANLAGTLSGHASW-VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
Query: 469 LHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502
F +H GV + + I S G D+ + Y
Sbjct: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 70.9 bits (172), Expect = 3e-12
Identities = 42/188 (22%), Positives = 80/188 (42%), Gaps = 2/188 (1%)
Query: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
D+ + TG V +F S + +L K + S+ + P + S + D I I+
Sbjct: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Query: 293 VPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
+ + + H + L+ L+++SDD Y D+Q + ++ S
Sbjct: 177 IATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW-- 234
Query: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412
+ F PD F + + D +K+WD+ RT V F H + + ++ NG + + D
Sbjct: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294
Query: 413 DSSVKLWD 420
D + ++D
Sbjct: 295 DQEIHIYD 302
Score = 37.4 bits (85), Expect = 0.032
Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 1/86 (1%)
Query: 209 QVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVT 268
Q A+ G S +L + CP DT+ ++ +DK+V V+D + + T H +V
Sbjct: 220 QHANLAGTLSGHASWVLNVAFCPDDTH-FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVW 278
Query: 269 SVVFHPSQDLVFSASPDATIRIWSVP 294
V ++ + + S D I I+ P
Sbjct: 279 GVKYNGNGSKIVSVGDDQEIHIYDCP 304
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 82.4 bits (202), Expect = 9e-16
Identities = 54/248 (21%), Positives = 117/248 (47%), Gaps = 12/248 (4%)
Query: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQ---ILATLKGHTKKVTSVVFHPSQDLV 279
G+ AL L P+ N++ T G D + ++ + + +A+++ HT V +V + +
Sbjct: 32 GVNALQLDPA-LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90
Query: 280 FSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGR 339
SAS D T+++W+ C+ +R H+ V L+ + + S+ D+ D+ T
Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150
Query: 340 VLTKVTDETSGCSLT-------CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS 392
LT + + SL+ + G I +G+ + +++WD + + GH+
Sbjct: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHT 210
Query: 393 GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLAL 452
+ ++ + +G + + D +++LW L + + T ++ + V +L + + T++
Sbjct: 211 DNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE-GVWALQVNDAFTHVYS 269
Query: 453 GGTDVQIY 460
GG D +IY
Sbjct: 270 GGRDRKIY 277
Score = 53.9 bits (128), Expect = 3e-07
Identities = 29/111 (26%), Positives = 54/111 (48%)
Query: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
I++G +K + V+D + L LKGHT V +++ + S S D TIR+WS+
Sbjct: 183 IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ 242
Query: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE 347
C+ R H+ V L ++ ++ S D+ +D++ + + +E
Sbjct: 243 RCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEE 293
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 82.4 bits (202), Expect = 9e-16
Identities = 52/255 (20%), Positives = 110/255 (43%), Gaps = 20/255 (7%)
Query: 261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 320
+G +T+ FH L+ + + +P + + + + ++ ++++++GD+
Sbjct: 285 EGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDW 344
Query: 321 LLSSSDDQYWAFSDIQTGRVLTKVTDETSGC--------SLTCAQFHPDGLIFGTGTMDS 372
+ AF G++L S S+ + PDG TG D
Sbjct: 345 I---------AFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDG 395
Query: 373 QIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL 432
++K+W+ F HS +T + F+ GY + T++ D +V+ +DL + +NF+T
Sbjct: 396 KVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTS 455
Query: 433 DNNFEVKSLIFDQSGTYLALGGTD-VQIYICKQWTEIL--HFTEHSGLTTGVAFGHHAKF 489
+ + D SG ++ G D +I++ T L + H G +G+ F
Sbjct: 456 PRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSV 515
Query: 490 IASTGMDRSLKFYSL 504
+AS D++++ + +
Sbjct: 516 LASASWDKTVRLWDM 530
Score = 81.3 bits (199), Expect = 2e-15
Identities = 54/216 (25%), Positives = 99/216 (45%), Gaps = 5/216 (2%)
Query: 246 VVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAH 305
++V++ SE + +GH + ++ + P + + D +++W+ + C H
Sbjct: 355 LLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414
Query: 306 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 365
S VTG++ ATG +++SS D D+ R T +C G I
Sbjct: 415 SSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRP-TQFSCVAVDASGEIV 473
Query: 366 GTGTMDS-QIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL-RK 423
G DS +I +W ++ + GH GPI+ + F+ LA+A+ D +V+LWD+
Sbjct: 474 SAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDS 533
Query: 424 LKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 459
+ +TL L + + ++ F G LA+ + QI
Sbjct: 534 WRTKETLALTS--DALAVTFRPDGAELAVATLNSQI 567
Score = 64.3 bits (155), Expect = 2e-10
Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 5/214 (2%)
Query: 209 QVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVT 268
Q S+V ++AL P D I+TGG D V V++ S T H+ VT
Sbjct: 361 QSESYVLKQQGHFNSMVALAYSP-DGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVT 419
Query: 269 SVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRA-HESAVTGLSLHATGDYLLSSSDD 327
V F + +V ++S D T+R + + + + + + +++ A+G+ + + + D
Sbjct: 420 GVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQD 479
Query: 328 QYWAFS-DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA 386
+ F +QTGR+L ++ S C F+P + + + D +++WD+ +
Sbjct: 480 SFEIFVWSMQTGRLLDVLSGHEGPISGLC--FNPMKSVLASASWDKTVRLWDMFDSWRTK 537
Query: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
+ ++ F +G LA A +S + WD
Sbjct: 538 ETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,253,810
Number of Sequences: 37866
Number of extensions: 853420
Number of successful extensions: 5365
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 267
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 2727
Number of HSP's gapped (non-prelim): 1410
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.