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Search of human proteins with 7656959
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7656959 calpain 7 [Homo sapiens]
(813 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7656959 calpain 7 [Homo sapiens] 1674 0.0
gi|37577157 calpain 5 [Homo sapiens] 117 4e-26
gi|5032105 small optic lobes [Homo sapiens] 110 7e-24
gi|13186316 calpain 6 [Homo sapiens] 102 2e-21
gi|41152101 calpain 13 [Homo sapiens] 99 2e-20
gi|223468608 calpain 14 [Homo sapiens] 97 6e-20
gi|12408656 calpain 1, large subunit [Homo sapiens] 96 1e-19
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 94 5e-19
gi|13186302 calpain 10 isoform a [Homo sapiens] 94 7e-19
gi|221554549 calpain 8 [Homo sapiens] 92 1e-18
gi|215490104 calpain 11 [Homo sapiens] 92 1e-18
gi|27765074 calpain 3 isoform c [Homo sapiens] 92 3e-18
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 92 3e-18
gi|38707981 calpain 12 [Homo sapiens] 89 2e-17
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 86 1e-16
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 82 2e-15
gi|4557405 calpain 3 isoform a [Homo sapiens] 78 4e-14
gi|27765072 calpain 3 isoform b [Homo sapiens] 78 4e-14
gi|47078247 calpain 3 isoform f [Homo sapiens] 72 2e-12
gi|89353291 calpain 10 isoform c [Homo sapiens] 72 3e-12
gi|168823435 hypothetical protein LOC79747 [Homo sapiens] 72 3e-12
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 43 0.001
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens] 42 0.003
gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1 i... 37 0.096
gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1 is... 37 0.096
gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens] 35 0.36
gi|20270349 MIT, microtubule interacting and transport, domain c... 33 1.1
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 33 1.4
gi|21314671 transient receptor potential cation channel, subfami... 33 1.4
gi|221316624 dystonin isoform 4 [Homo sapiens] 33 1.4
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 1674 bits (4334), Expect = 0.0
Identities = 813/813 (100%), Positives = 813/813 (100%)
Query: 1 MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEY 60
MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEY
Sbjct: 1 MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEY 60
Query: 61 LERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLC 120
LERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLC
Sbjct: 61 LERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLC 120
Query: 121 LKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLG 180
LKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLG
Sbjct: 121 LKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLG 180
Query: 181 ANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMP 240
ANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMP
Sbjct: 181 ANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMP 240
Query: 241 FCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISA 300
FCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISA
Sbjct: 241 FCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISA 300
Query: 301 AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL 360
AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL
Sbjct: 301 AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL 360
Query: 361 CSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKD 420
CSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKD
Sbjct: 361 CSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKD 420
Query: 421 NSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPW 480
NSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPW
Sbjct: 421 NSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPW 480
Query: 481 SHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNP 540
SHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNP
Sbjct: 481 SHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNP 540
Query: 541 GLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFA 600
GLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFA
Sbjct: 541 GLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFA 600
Query: 601 NNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYE 660
NNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYE
Sbjct: 601 NNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYE 660
Query: 661 KQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFH 720
KQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFH
Sbjct: 661 KQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFH 720
Query: 721 IEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSG 780
IEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSG
Sbjct: 721 IEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSG 780
Query: 781 IFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ 813
IFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ
Sbjct: 781 IFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ 813
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 117 bits (293), Expect = 4e-26
Identities = 109/406 (26%), Positives = 179/406 (44%), Gaps = 64/406 (15%)
Query: 260 KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318
+W RP+ + +P + +SS + Q V +C FVA+ + A+ E + K + P
Sbjct: 50 RWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQK------VIPD 103
Query: 319 NKDGEPEYNPCGKYMVKLHLN----GVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSL 374
K+ E + Y H + G V+IDD+LP + + C +SN+++E W +L
Sbjct: 104 WKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYC-HSNSRNEFWCAL 162
Query: 375 IEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFR-MLYQRF-- 430
+EKAY K+ G Y G N+ L TG + E I + F+ D + R L++R
Sbjct: 163 VEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGD--FANDETKRNQLFERMLK 220
Query: 431 -HKGDVLITASTGMMTEAEGE---KWGLVPTHAYAVLDIRE----------FKG--LRFI 474
H LI+AS +T A+ E GLV HAYAV D+R+ FK L I
Sbjct: 221 VHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMI 280
Query: 475 QLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYY-DV 533
+L+NPW W G +S+ + W + T Q D+G FW++++D+C+Y+ D+
Sbjct: 281 RLRNPWGEREWNGPWSDTS-EEWQKVSKSEREKMGVTVQ--DDGEFWMTFEDVCRYFTDI 337
Query: 534 ------------IYLSWNPGLFKESTCIHSTWDAKQGP--------VKDAYSLANNPQYK 573
I+ +W E +H W + P + + NPQY
Sbjct: 338 IKCRVINTSHLSIHKTW------EEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYI 391
Query: 574 LEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVY 619
EV+ P+ + + + + + I +YK + + Y
Sbjct: 392 FEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQY 437
Score = 39.7 bits (91), Expect = 0.011
Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 19/142 (13%)
Query: 691 RINGKWS------GQSAGGCGNFQETHKNNPIYQFHIEKTGP---LLIELRGPRQ----- 736
R++G W+ GGC N ++T NP Y F ++K + I+ R R
Sbjct: 358 RLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREG 417
Query: 737 ----YSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELE-NIPSGIFNIIPSTFLP 791
++GF++ V H K++ + L + P G + IIP+TF P
Sbjct: 418 KGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477
Query: 792 KQEGPFFLDFNSIIPIKITQLQ 813
G F L + +P +L+
Sbjct: 478 GHTGEFLLRVFTDVPSNCRELR 499
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 110 bits (274), Expect = 7e-24
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 37/293 (12%)
Query: 260 KWVRPEDLTNNP--------TMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLI 311
+W+RP+++ + ++ +T+ I Q ++ +C F+++LA+ A + ++
Sbjct: 514 QWLRPQEINCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMV 573
Query: 312 TGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELW 371
T + + G Y V+L +G V++DD LP D G LL S + K +LW
Sbjct: 574 TRSLCAE-----------GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRK-QLW 621
Query: 372 VSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDS-----QTFSKDNSFRM 425
V+LIEKA K+ G Y + I+ L LTG E +A+ S + D +
Sbjct: 622 VALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAK 681
Query: 426 LYQRFHKGDVLITASTG----MMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWS 481
+ G L+ AS G + ++ E GL P HAY++LD+R+ +G R ++L+NPW
Sbjct: 682 MLSSKEAG-FLMGASCGGGNMKVDDSAYESLGLRPRHAYSILDVRDVQGTRLLRLRNPWG 740
Query: 482 HLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI 534
W G +S+ + +W L+ L G+FW+ + D +Y+D +
Sbjct: 741 RFSWNGSWSD-EWPHWPGHLRGEL-----MPHGSSEGVFWMEYGDFVRYFDSV 787
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 102 bits (253), Expect = 2e-21
Identities = 112/461 (24%), Positives = 196/461 (42%), Gaps = 71/461 (15%)
Query: 261 WVRPEDLTNNPTMIY-TVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP+D+ ++P +I +S+ + Q + V++ + A E + K + P +
Sbjct: 51 WKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTI------PNH 104
Query: 320 KDGEPEYNPCGKYMVKLHLN----GVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLI 375
K+ E + KY H G +V+IDD LP + G+L+ S+S + +E W +L+
Sbjct: 105 KEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTIN-GDLVFSFSTSMNEFWNALL 163
Query: 376 EKAYMKVMGGYDFPGSNSNIDLHA-LTGWIPERIAMHSDSQTFSKDNSFRM---LYQRFH 431
EKAY K++G Y+ + D+ TG + E + M T + +++ LY+ F
Sbjct: 164 EKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFT 223
Query: 432 KGDVLITASTGMMTEAEGE---KWGLVPTHAYAVLDIREFK-GLRFIQ-----------L 476
KG LI S + E E WGL+ H Y + DIR+ + G R ++ L
Sbjct: 224 KGG-LICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRL 282
Query: 477 KNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKI--DNGIFWISWDDLCQYYDVI 534
+NP W G +SE + E Q+ D + + D+G FW+S +D C+ + +
Sbjct: 283 RNPLGRQEWSGPWSE-----ISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKL 337
Query: 535 YL--SWNPGLF--KESTCIHSTWDAKQGPV--------KDAYSLANNPQYKLEVQCPQGG 582
+ + N +F KE + W P+ + + NPQY V P+ G
Sbjct: 338 NVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTV--PEDG 395
Query: 583 AAVWVLLS-------RHITDKDDFANNREFITMVV---YKTDGKKVYYPADPPPYIDGIR 632
V + L R + D++ E + + ++ + A YID
Sbjct: 396 HKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRT 455
Query: 633 INSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYS 673
+ YL K + LV + ++ T + +R++S
Sbjct: 456 VFLSKYLKK--------GNYVLVPTMFQHGRTSEFLLRIFS 488
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/130 (23%), Positives = 56/130 (43%), Gaps = 21/130 (16%)
Query: 701 AGGCGNFQETHKNNPIYQFHIEKTGPLLI------------ELRGPRQYSVGFEVVTVST 748
+GGC N ++T NP Y F + + G +I + P Y +GFE+ V
Sbjct: 371 SGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEM 430
Query: 749 LGDPGPHG-FLRKSSG-----DYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFN 802
H ++++ +G D R F L+ G + ++P+ F + F L
Sbjct: 431 NRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLK---KGNYVLVPTMFQHGRTSEFLLRIF 487
Query: 803 SIIPIKITQL 812
S +P+++ +L
Sbjct: 488 SEVPVQLREL 497
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 99.0 bits (245), Expect = 2e-20
Identities = 105/394 (26%), Positives = 163/394 (41%), Gaps = 46/394 (11%)
Query: 261 WVRPEDLTNNPT--MIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318
W RP+DL P ++ +S F I+Q +DC F+A+L S ++ +K++ +
Sbjct: 62 WKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALG-SLTQNPQYRQKILMVQSFSH 120
Query: 319 NKDGEPEYN--PCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIE 376
G + CG+++ +V+IDD+LPV L + E W L+E
Sbjct: 121 QYAGIFRFRFWQCGQWV----------EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLE 170
Query: 377 KAYMKVMGGY-DFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDV 435
KAY K++G Y D L LTG + I +HS K + K
Sbjct: 171 KAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVK------AVKTATKAGS 224
Query: 436 LITAST--GMMTEAEGEKWGLVPTHAYAVLDIREFKGLR----FIQLKNP--WSHLRWKG 487
LIT +T G A+ + GLV HAY V + + R I L NP W W+G
Sbjct: 225 LITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRG 284
Query: 488 RYSENDVKNWTPELQKYLNFDPRTAQ---KIDNGIFWISWDDLCQYYDVIYL-SWNPGLF 543
R+S+ + W DPR +Q K ++G FW+S D Q + +++ S P
Sbjct: 285 RWSDGS-QEWEE------TCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITL 337
Query: 544 KESTCIHSTWD----AKQGPV-KDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDD 598
+H W KQ + A N+ Q+ VQ P G V V ++ +T +
Sbjct: 338 DHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNL 397
Query: 599 FANNREFITMVVYKTDGKKVYYPADPPPYIDGIR 632
A + +F G + + PP + R
Sbjct: 398 KAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFR 431
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 97.1 bits (240), Expect = 6e-20
Identities = 93/351 (26%), Positives = 162/351 (46%), Gaps = 58/351 (16%)
Query: 260 KWVRPEDLTNNPTMIYTVSS-FSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318
+W RP +L +NP + + + Q IV DC F+A+L A ++ ++ + P
Sbjct: 70 QWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSR------VVPL 123
Query: 319 NKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKA 378
N+ +Y ++ + N VP V+IDD+LPV+ G+L+ S K+ W +L+EKA
Sbjct: 124 NQSFTEKYAGIFRFWFWHYGNWVP--VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKA 181
Query: 379 YMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
Y K+ G Y+ DL +G + E + + T + + + D+LI
Sbjct: 182 YAKLSGSYE--------DLQ--SGQVSEALVDFTGGVTM----TINLAEAHGNLWDILIE 227
Query: 439 AS-----TGMMTEAEGEKW---GLVPTHAYAVLDIR----EFKGLRFIQLKNPWSHLRWK 486
A+ G T + GEK GLV HAY + IR + + ++L+NPW + WK
Sbjct: 228 ATYNRTLIGCQTHS-GEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWK 286
Query: 487 GRYSENDVKNW---TPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYL-SWNPGL 542
G +S++ K W +P+ +K L +K ++G FW++ D ++ ++ + PGL
Sbjct: 287 GDWSDSSSK-WELLSPK-EKIL-----LLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGL 339
Query: 543 FKESTCIHSTWDAKQGPVKDAYSLA-----------NNPQYKLEVQCPQGG 582
+ T+ ++G + + NPQ+ L V P+ G
Sbjct: 340 LSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEG 390
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 95.9 bits (237), Expect = 1e-19
Identities = 120/482 (24%), Positives = 204/482 (42%), Gaps = 75/482 (15%)
Query: 189 QSFISPQSC---DAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERF---------- 235
+ I+P C AQ Q+ A E+ + R N I+Y+ LR R
Sbjct: 3 EEIITPVYCTGVSAQVQKQRARELGLGRHE---NAIKYLGQDYEQLRVRCLQSGTLFRDE 59
Query: 236 AYPMPFCDRWGKLPLSPKQKTTFS-KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFV 293
A+P P G L P T+ KW RP +L +NP I + I Q + DC +
Sbjct: 60 AFP-PVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLL 118
Query: 294 ASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPV 353
A++A N L+ ++ P + + Y G + +L G V++DD LP+
Sbjct: 119 AAIA-----SLTLNDTLLHRVV-PHGQSFQNGY--AGIFHFQLWQFGEWVDVVVDDLLPI 170
Query: 354 DHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHS 412
G+L+ +S +E W +L+EKAY KV G Y+ G +++ TG + E +
Sbjct: 171 KD-GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRK 229
Query: 413 DSQTFSKDNSFRMLYQRFHKGDVL---ITASTGMMTEAEGEKWGLVPTHAYAVLDIRE-- 467
+ + ++++ + +G +L I S+ + EA K LV HAY+V ++
Sbjct: 230 -----APSDLYQIILKALERGSLLGCSIDISSVLDMEAITFK-KLVKGHAYSVTGAKQVN 283
Query: 468 FKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP----RTAQKIDNGIFW 521
++G + I+++NPW + W G W+ ++ N DP + K+++G FW
Sbjct: 284 YRGQVVSLIRMRNPWGEVEWTGA--------WSDSSSEWNNVDPYERDQLRVKMEDGEFW 335
Query: 522 ISWDDLCQYYDVIYL-SWNPGLFK-------ESTCIHSTW---DAKQGPVKDAYSLANNP 570
+S+ D + + + + + P K +T TW G + NP
Sbjct: 336 MSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNP 395
Query: 571 QYKL---EVQCP-------QGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYY 620
Q+K+ E P G + V L+ +H + F + E I VY+ + V
Sbjct: 396 QFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQ 455
Query: 621 PA 622
PA
Sbjct: 456 PA 457
Score = 38.9 bits (89), Expect = 0.019
Identities = 42/162 (25%), Positives = 64/162 (39%), Gaps = 42/162 (25%)
Query: 684 SPYTLSKRINGKWS----------GQSAGGCGNFQETHKNNPIYQFHIEKTGP------- 726
+P L R KW+ G +AGGC N+ T NP ++ +++T
Sbjct: 354 TPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDR 413
Query: 727 ----------LLIELRGPRQY-----SVGFEVVTV--STLGDPGPH----GFLRKSSGDY 765
+ R R++ ++GF V V +G P H FL +S
Sbjct: 414 ESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRAR 473
Query: 766 RCGFCYLELEN----IPSGIFNIIPSTFLPKQEGPFFLDFNS 803
F L + +P G + ++PSTF P +EG F L F S
Sbjct: 474 SEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFS 515
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 94.0 bits (232), Expect = 5e-19
Identities = 78/289 (26%), Positives = 137/289 (47%), Gaps = 34/289 (11%)
Query: 255 KTTFSKWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITG 313
KT +W RP ++ +P I + I Q + DC +A++A N++++
Sbjct: 69 KTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIA-----SLTLNEEILAR 123
Query: 314 IIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVS 373
++ P N+ + Y G + + G +V++DD+LP GELL +S SE W +
Sbjct: 124 VV-PLNQSFQENY--AGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSA 179
Query: 374 LIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHK 432
L+EKAY K+ G Y+ G + TG I E + N F+++ + K
Sbjct: 180 LLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKK-----PPPNLFKIIQKALQK 234
Query: 433 GDVLITASTGMMTEAEGEK---WGLVPTHAYAVLDIREFKG----LRFIQLKNPWSHLRW 485
G L+ S + + A+ E LV HAY+V E + + I+++NPW + W
Sbjct: 235 GS-LLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEW 293
Query: 486 KGRYSENDVKNWT---PELQKYLNFDPRTAQKIDNGIFWISWDDLCQYY 531
GR+++N +W PE ++ R ++ ++G FW+S+ D ++Y
Sbjct: 294 TGRWNDN-CPSWNTIDPEERE------RLTRRHEDGEFWMSFSDFLRHY 335
Score = 34.3 bits (77), Expect = 0.48
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 31/138 (22%)
Query: 691 RINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG----------PLLIEL-------- 731
+++G W G +AGGC N+ T NP Y +E+ L+ L
Sbjct: 360 KMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQ 419
Query: 732 --RGPRQYSVGFEVVTV--STLGDPGPH----GFLRKSSGDYRCGFCYL-ELEN---IPS 779
G +++GF + V G H FL + + F L E+ N +P
Sbjct: 420 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 479
Query: 780 GIFNIIPSTFLPKQEGPF 797
G + ++PSTF P ++G F
Sbjct: 480 GEYILVPSTFEPNKDGDF 497
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 93.6 bits (231), Expect = 7e-19
Identities = 142/619 (22%), Positives = 238/619 (38%), Gaps = 105/619 (16%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYP-Q 318
W RP+++ P + +KQ ++ DC F L AA ++ ++ L+ +I P Q
Sbjct: 43 WRRPQEICATPRLFPDDPREGQVKQGLLGDCWF---LCACAALQK--SRHLLDQVIPPGQ 97
Query: 319 NKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKA 378
+ EY G + ++ G +V DD+LP G L S + W+ L+EK
Sbjct: 98 PSWADQEYR--GSFTCRIWQFGRWVEVTTDDRLPC-LAGRLCFSRCQREDVFWLPLLEKV 154
Query: 379 YMKVMGGYDFPGSNSNID-LHALTGWIPER-----IAMHSDSQTFSKDNSFRMLYQRFHK 432
Y KV G Y+ + D L LTG + ER +A Q R Q H
Sbjct: 155 YAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHL 214
Query: 433 GDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKG-----LRFIQLKNPWSHLRWKG 487
D + + + A + G HA+ V D+RE +G + ++++NPW W+G
Sbjct: 215 KDQCLISCCVLSPRAGARELG--EFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQG 272
Query: 488 RYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWIS-------WDDLCQYYDVIYLSWNP 540
+ E + W+ Q ++ G FW+ +D+L Y V
Sbjct: 273 LWREGG-EGWS---QVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQ 328
Query: 541 GLFKESTCIHS-----TWDAKQ--GPVKDAYSLANNPQYKLEVQCPQGGAAVWV-LLSRH 592
L+ E H+ W Q G ++ +NP++ L V P + V++ +L R
Sbjct: 329 SLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEP---SEVYIAVLQRS 385
Query: 593 ITDKDDFANNREFITMVVYKTDGKKVYYPADPPPY-----------IDGIRINSPHYLTK 641
D+A + D + PA P ++ R+N P L+
Sbjct: 386 RLHAADWAGRARALV-----GDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSM 440
Query: 642 IKLTTPGTHTFT---------------LVVSQYEKQNTIHYTVRVYSACSFTFSKI---- 682
+ H + V S + K + +RV+S + S I
Sbjct: 441 PPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVA 500
Query: 683 ---------PSPYTLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHI-EKTGPLLIEL 731
P+ + ++ G W GQ+AGG NF ++ NP + F + E GP + +
Sbjct: 501 KNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPEGPGPRCVRI 559
Query: 732 RGPRQ--------YSVGFEVVTVSTLG--DPGPHGFLRK---SSGDYRCGFCYLELENIP 778
+ + +GF + V G P L++ S +R L +P
Sbjct: 560 TLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLP 619
Query: 779 SGIFNIIPSTFLPKQEGPF 797
+G + ++PST+LP EG F
Sbjct: 620 AGTYKVVPSTYLPDTEGAF 638
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 92.4 bits (228), Expect = 1e-18
Identities = 79/284 (27%), Positives = 137/284 (48%), Gaps = 36/284 (12%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP +L +P I + I Q + DC +A++A N++L+ ++ P++
Sbjct: 75 WKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIA-----SLTLNEELLYRVV-PRD 128
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+D + Y G + + G +V+IDD+LP + G+LL +S +E W +L+EKAY
Sbjct: 129 QDFQENY--AGIFHFQFWQYGEWVEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALLEKAY 185
Query: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
K+ G Y+ S ++ TG I E + N ++++ + G L+
Sbjct: 186 AKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPA-----NLYQIIRKALCAGS-LLG 239
Query: 439 ASTGMMTEAEGE---KWGLVPTHAYAVLDIRE--FKG--LRFIQLKNPWSHLRWKGRYSE 491
S + + AE E LV +HAY+V + E F+G + I+L+NPW + W G +S+
Sbjct: 240 CSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSD 299
Query: 492 NDVKNWTPELQKYLNFDPRTAQ----KIDNGIFWISWDDLCQYY 531
D W + DPR + K+++G FW+S D + +
Sbjct: 300 -DAPEWN-------HIDPRRKEELDKKVEDGEFWMSLSDFVRQF 335
Score = 33.9 bits (76), Expect = 0.62
Identities = 35/140 (25%), Positives = 53/140 (37%), Gaps = 33/140 (23%)
Query: 693 NGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG---------PLLIELRGPRQ------ 736
NG W+ G +AGGC N+ T+ NP ++ +++ P L G Q
Sbjct: 362 NGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWR 421
Query: 737 -------YSVGFEVVTV------STLGDPGPHGFLRKSSGDYRCGFCYLE----LENIPS 779
S+G+ V V T G FL + L +P
Sbjct: 422 KRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPP 481
Query: 780 GIFNIIPSTFLPKQEGPFFL 799
G + ++PSTF P ++G F L
Sbjct: 482 GEYLVVPSTFEPFKDGEFCL 501
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 92.4 bits (228), Expect = 1e-18
Identities = 83/353 (23%), Positives = 158/353 (44%), Gaps = 42/353 (11%)
Query: 250 LSPKQKTTFS-KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFN 307
L P K + W RP+D+ NNP I +S I Q I+ DC +A++ +
Sbjct: 97 LGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLY 156
Query: 308 KKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNK 367
+ + P+ + + Y G + ++ G V++DD+LP + +L+ +S +
Sbjct: 157 R------VVPRGQSFKKNY--AGIFHFQIWQFGQWVNVVVDDRLPTKND-KLVFVHSTER 207
Query: 368 SELWVSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRML 426
SE W +L+EKAY K+ G Y+ S ++ L TG + + + Q N R+L
Sbjct: 208 SEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQ-----NLLRLL 262
Query: 427 YQRFHKGDVL---ITASTGMMTEAEGEKWGLVPTHAYAVLDIREF----KGLRFIQLKNP 479
+ + ++ I ++ E+ +K LV HAY+V +++ K I+++NP
Sbjct: 263 RKAVERSSLMGCSIEVTSDSELESMTDKM-LVRGHAYSVTGLQDVHYRGKMETLIRVRNP 321
Query: 480 WSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI----- 534
W + W G +S++ + W + + + K ++G FW+S+ D + ++
Sbjct: 322 WGRIEWNGAWSDS-AREWE---EVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNL 377
Query: 535 ---YLSWNPGLFKESTCIHSTW---DAKQGPVKDAYSLANNPQYKLEVQCPQG 581
LS + + +T +W + G + NPQ+K+ + P+G
Sbjct: 378 TPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISL--PEG 428
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 91.7 bits (226), Expect = 3e-18
Identities = 76/283 (26%), Positives = 139/283 (49%), Gaps = 33/283 (11%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP ++ NP I + I Q + DC F+A++A N+ L+ +I P +
Sbjct: 99 WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+ Y G + + G V+IDD LP + +L+ + SN+++E W +L+EKAY
Sbjct: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
Query: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
K+ G Y+ G N+ + TG + E + + + ++++ + +G L+
Sbjct: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRD-----APSDMYKIMKKAIERGS-LMG 263
Query: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSE 491
S + + E GLV HAY+V LD FKG ++ ++L+NPW + W G +S+
Sbjct: 264 CSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSD 323
Query: 492 NDVKNWTPELQKYLNFDPRTA---QKIDNGIFWISWDDLCQYY 531
K+W+ +++ D + Q ++G FW+S++D ++
Sbjct: 324 R-WKDWS-----FVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 360
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)
Query: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732
G+W G SAGGC NF +T NP Y+ + E L+ L
Sbjct: 388 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 447
Query: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782
G +++GF + V G L+K Y Y+ + + P +
Sbjct: 448 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 506
Query: 783 NIIPSTFLPKQEGPFFL 799
I+PST+ P QEG F L
Sbjct: 507 VIVPSTYEPHQEGEFIL 523
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 91.7 bits (226), Expect = 3e-18
Identities = 78/285 (27%), Positives = 135/285 (47%), Gaps = 31/285 (10%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP ++ NP I + I Q + DC +A++A N+K + +I PQ+
Sbjct: 67 WKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIA-----SLTLNQKALARVI-PQD 120
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+ P Y + H + V+IDD+LP + L+ +S + +E W +L+EKAY
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLD--VVIDDRLPT-FRDRLVFLHSADHNEFWSALLEKAY 177
Query: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
K+ G Y+ S I+ + TG + E QT +F + ++ K L+
Sbjct: 178 AKLNGSYEALKGGSAIEAMEDFTGGVAETF------QTKEAPENFYEILEKALKRGSLLG 231
Query: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKGLR--FIQLKNPWSHLRWKGRYSE 491
+ AE E +GL+ HAY+V +D F+G R I+++NPW + W G +S+
Sbjct: 232 CFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD 291
Query: 492 N--DVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI 534
+ + ++ P QK L +D+G FW+++ D ++D +
Sbjct: 292 SSPEWRSVGPAEQKRL-----CHTALDDGEFWMAFKDFKAHFDKV 331
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 88.6 bits (218), Expect = 2e-17
Identities = 80/303 (26%), Positives = 134/303 (44%), Gaps = 30/303 (9%)
Query: 243 DRWGKLPLSP-KQKTTFSKWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISA 300
D G L P +K KW+RP + P I +S + Q + +C F+A+ A
Sbjct: 56 DALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLT 115
Query: 301 AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL 360
Y R + + P +D + Y G + +L G V++DD+LPV +G+L+
Sbjct: 116 LYPRLLRR------VVPPGQDFQHGY--AGVFHFQLWQFGRWMDVVVDDRLPV-REGKLM 166
Query: 361 CSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSK 419
S ++E W L+EKAY K+ G Y+ G + N TG + E + + +S
Sbjct: 167 FVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSM---- 222
Query: 420 DNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIRE----FKGLRFIQ 475
F L K ++ + E E+ GLV HAY++ + F +R ++
Sbjct: 223 -GLFSALRHALAKESLVGATALSDRGEYRTEE-GLVKGHAYSITGTHKVFLGFTKVRLLR 280
Query: 476 LKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTA--QKIDNGIFWISWDDLCQYYDV 533
L+NPW + W G +S++ W L + R A K ++G FW+ D ++D
Sbjct: 281 LRNPWGCVEWTGAWSDS-CPRWDT-----LPTECRDALLVKKEDGEFWMELRDFLLHFDT 334
Query: 534 IYL 536
+ +
Sbjct: 335 VQI 337
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 86.3 bits (212), Expect = 1e-16
Identities = 71/261 (27%), Positives = 125/261 (47%), Gaps = 33/261 (12%)
Query: 282 IKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGV 341
I Q + DC +A++A N++++ ++ P N+ + Y G + + G
Sbjct: 19 ICQGALGDCWLLAAIA-----SLTLNEEILARVV-PLNQSFQENY--AGIFHFQFWQYGE 70
Query: 342 PRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHAL 400
+V++DD+LP GELL +S SE W +L+EKAY K+ G Y+ G +
Sbjct: 71 WVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDF 129
Query: 401 TGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEK---WGLVPT 457
TG I E + N F+++ + KG L+ S + + A+ E LV
Sbjct: 130 TGGIAEWYELKK-----PPPNLFKIIQKALQKGS-LLGCSIDITSAADSEAITFQKLVKG 183
Query: 458 HAYAVLDIREFKG----LRFIQLKNPWSHLRWKGRYSENDVKNWT---PELQKYLNFDPR 510
HAY+V E + + I+++NPW + W GR+++N +W PE ++ R
Sbjct: 184 HAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN-CPSWNTIDPEERE------R 236
Query: 511 TAQKIDNGIFWISWDDLCQYY 531
++ ++G FW+S+ D ++Y
Sbjct: 237 LTRRHEDGEFWMSFSDFLRHY 257
Score = 34.3 bits (77), Expect = 0.48
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 31/138 (22%)
Query: 691 RINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG----------PLLIEL-------- 731
+++G W G +AGGC N+ T NP Y +E+ L+ L
Sbjct: 282 KMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQ 341
Query: 732 --RGPRQYSVGFEVVTV--STLGDPGPH----GFLRKSSGDYRCGFCYL-ELEN---IPS 779
G +++GF + V G H FL + + F L E+ N +P
Sbjct: 342 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 401
Query: 780 GIFNIIPSTFLPKQEGPF 797
G + ++PSTF P ++G F
Sbjct: 402 GEYILVPSTFEPNKDGDF 419
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 82.4 bits (202), Expect = 2e-15
Identities = 68/240 (28%), Positives = 113/240 (47%), Gaps = 24/240 (10%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP ++ NP I + I Q + DC +A++A N+K + +I PQ+
Sbjct: 67 WKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIA-----SLTLNQKALARVI-PQD 120
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+ P Y + H + V+IDD+LP + L+ +S + +E W +L+EKAY
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLD--VVIDDRLPT-FRDRLVFLHSADHNEFWSALLEKAY 177
Query: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
K+ G Y+ S I+ + TG + E QT +F + ++ K L+
Sbjct: 178 AKLNGSYEALKGGSAIEAMEDFTGGVAETF------QTKEAPENFYEILEKALKRGSLLG 231
Query: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKGLR--FIQLKNPWSHLRWKGRYSE 491
+ AE E +GL+ HAY+V +D F+G R I+++NPW + W G +S+
Sbjct: 232 CFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD 291
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 69/325 (21%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP ++ NP I + I Q + DC F+A++A N+ L+ +I P +
Sbjct: 99 WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+ Y G + + G V+IDD LP + +L+ + SN+++E W +L+EKAY
Sbjct: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
Query: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMH---SDSQTFSK-------------DNS 422
K+ G Y+ G N+ + TG + E + SD K D+
Sbjct: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDG 269
Query: 423 FRMLYQRFHKG--------------DVLITASTGMMTEAEGEK---------------WG 453
M Y G D + + + E+ G
Sbjct: 270 TNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACG 329
Query: 454 LVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP 509
LV HAY+V LD FKG ++ ++L+NPW + W G +S+ K+W+ +++ D
Sbjct: 330 LVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDR-WKDWS-----FVDKDE 383
Query: 510 RTA---QKIDNGIFWISWDDLCQYY 531
+ Q ++G FW+S++D ++
Sbjct: 384 KARLQHQVTEDGEFWMSYEDFIYHF 408
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)
Query: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732
G+W G SAGGC NF +T NP Y+ + E L+ L
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
Query: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782
G +++GF + V G L+K Y Y+ + + P +
Sbjct: 496 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 554
Query: 783 NIIPSTFLPKQEGPFFL 799
I+PST+ P QEG F L
Sbjct: 555 VIVPSTYEPHQEGEFIL 571
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 69/325 (21%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
W RP ++ NP I + I Q + DC F+A++A N+ L+ +I P +
Sbjct: 99 WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
Query: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
+ Y G + + G V+IDD LP + +L+ + SN+++E W +L+EKAY
Sbjct: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
Query: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMH---SDSQTFSK-------------DNS 422
K+ G Y+ G N+ + TG + E + SD K D+
Sbjct: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDG 269
Query: 423 FRMLYQRFHKG--------------DVLITASTGMMTEAEGEK---------------WG 453
M Y G D + + + E+ G
Sbjct: 270 TNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACG 329
Query: 454 LVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP 509
LV HAY+V LD FKG ++ ++L+NPW + W G +S+ K+W+ +++ D
Sbjct: 330 LVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDR-WKDWS-----FVDKDE 383
Query: 510 RTA---QKIDNGIFWISWDDLCQYY 531
+ Q ++G FW+S++D ++
Sbjct: 384 KARLQHQVTEDGEFWMSYEDFIYHF 408
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)
Query: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732
G+W G SAGGC NF +T NP Y+ + E L+ L
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
Query: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782
G +++GF + V G L+K Y Y+ + + P +
Sbjct: 496 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 554
Query: 783 NIIPSTFLPKQEGPFFL 799
I+PST+ P QEG F L
Sbjct: 555 VIVPSTYEPHQEGEFIL 571
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 72.0 bits (175), Expect = 2e-12
Identities = 83/336 (24%), Positives = 142/336 (42%), Gaps = 73/336 (21%)
Query: 250 LSPKQKTTFSKWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNK 308
+S K +TT K ++ NP I + I Q + DC F+A++A N+
Sbjct: 5 ISLKTQTTQQK----NEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQ 55
Query: 309 KLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKS 368
L+ +I P ++ Y G + + G V+IDD LP + +L+ + SN+++
Sbjct: 56 HLLFRVI-PHDQSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRN 111
Query: 369 ELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMH---SDSQTFSK----- 419
E W +L+EKAY K+ G Y+ G N+ + TG + E + SD K
Sbjct: 112 EFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIER 171
Query: 420 --------DNSFRMLYQRFHKG--------------DVLITASTGMMTEAEGEK------ 451
D+ M Y G D + + + E+
Sbjct: 172 GSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTII 231
Query: 452 ---------WGLVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSENDVKNWT 498
GLV HAY+V LD FKG ++ ++L+NPW + W G +S+ K+W+
Sbjct: 232 PVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDR-WKDWS 290
Query: 499 PELQKYLNFDPRTA---QKIDNGIFWISWDDLCQYY 531
+++ D + Q ++G FW+S++D ++
Sbjct: 291 -----FVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 321
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)
Query: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732
G+W G SAGGC NF +T NP Y+ + E L+ L
Sbjct: 349 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 408
Query: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782
G +++GF + V G L+K Y Y+ + + P +
Sbjct: 409 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 467
Query: 783 NIIPSTFLPKQEGPFFL 799
I+PST+ P QEG F L
Sbjct: 468 VIVPSTYEPHQEGEFIL 484
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 71.6 bits (174), Expect = 3e-12
Identities = 85/346 (24%), Positives = 139/346 (40%), Gaps = 41/346 (11%)
Query: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYP-Q 318
W RP+++ P + +KQ ++ DC F L AA ++ ++ L+ +I P Q
Sbjct: 43 WRRPQEICATPRLFPDDPREGQVKQGLLGDCWF---LCACAALQK--SRHLLDQVIPPGQ 97
Query: 319 NKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKA 378
+ EY G + ++ G +V DD+LP G L S + W+ L+EK
Sbjct: 98 PSWADQEYR--GSFTCRIWQFGRWVEVTTDDRLPC-LAGRLCFSRCQREDVFWLPLLEKV 154
Query: 379 YMKVMGGYDFPGSNSNID-LHALTGWIPER-----IAMHSDSQTFSKDNSFRMLYQRFHK 432
Y KV G Y+ + D L LTG + ER +A Q R Q H
Sbjct: 155 YAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHL 214
Query: 433 GDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKG-----LRFIQLKNPWSHLRWKG 487
D + + + A + G HA+ V D+RE +G + ++++NPW W+G
Sbjct: 215 KDQCLISCCVLSPRAGARELG--EFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQG 272
Query: 488 RYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWI-------SWDDLCQYYDVIYLSWNP 540
+ E + W+ Q ++ G FW+ +D+L Y V
Sbjct: 273 LWREGG-EGWS---QVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQ 328
Query: 541 GLFKESTCIHS-----TWDAKQ--GPVKDAYSLANNPQYKLEVQCP 579
L+ E H+ W Q G ++ +NP++ L V P
Sbjct: 329 SLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEP 374
Score = 30.8 bits (68), Expect = 5.3
Identities = 10/21 (47%), Positives = 16/21 (76%)
Query: 777 IPSGIFNIIPSTFLPKQEGPF 797
+P+G + ++PST+LP EG F
Sbjct: 463 LPAGTYKVVPSTYLPDTEGAF 483
>gi|168823435 hypothetical protein LOC79747 [Homo sapiens]
Length = 1667
Score = 71.6 bits (174), Expect = 3e-12
Identities = 64/215 (29%), Positives = 92/215 (42%), Gaps = 60/215 (27%)
Query: 241 FCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIY-----TVSSFSIKQTIVSDCSFVAS 295
F D GK+ L P K W RP+D+ + T + T FS + ++ CS +
Sbjct: 82 FEDPEGKIELPPSLK--IYSWKRPQDILFSQTPVVVKNEITFDLFSANEHLL--CSELMR 137
Query: 296 LAISAAYE--RRFNKKLITGIIYPQNKDGEPE-----------------------YNPCG 330
IS Y + FN +++ Y + GEP +N G
Sbjct: 138 WIISEIYAVWKIFNGGILSN--YFKGTSGEPPLLPWKPWEHIYSLCKAVKGHMPLFNSYG 195
Query: 331 KYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPG 390
KY+VKL+ G RK+ IDD LP D LL + + ELW L+ KA +K+
Sbjct: 196 KYVVKLYWMGCWRKITIDDFLPFDEDNNLLLPATTYEFELWPMLLSKAIIKL-------- 247
Query: 391 SNSNID--------------LHALTGWIPERIAMH 411
+NID +HALTGW+PE I++H
Sbjct: 248 --ANIDIHVADRRELGEFTVIHALTGWLPEVISLH 280
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/69 (37%), Positives = 39/69 (56%), Gaps = 1/69 (1%)
Query: 87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKT-SYETADKVLQNKLKQLARQALD 145
L++A LVT+A +ED+ +N E+A+ LY AV+ L YE + ++ Q LD
Sbjct: 6 LQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLD 65
Query: 146 RAEALSEPL 154
RAE L + L
Sbjct: 66 RAEKLKDYL 74
>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
Length = 444
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 86 DLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLK-TSYETADKVLQNKLKQLARQAL 144
+L++A L ++A ED+ N E+A++LY AV L YE + ++ + L
Sbjct: 7 NLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYL 66
Query: 145 DRAEALSEPLTKPVGKISSTSVKPKPPP 172
DRAE L E L K + +P P
Sbjct: 67 DRAEKLKEYLKNKEKKAQKPVKEGQPSP 94
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/145 (26%), Positives = 56/145 (38%), Gaps = 32/145 (22%)
Query: 10 AVQFARLAVQRDHEGRYSEAVFYYKEAAQALI----YAEMAGSSLENIQEKITEYLERVQ 65
A+ A A Q D G Y EA+ Y+ A Q + Y + ++I+ K TEYL+R +
Sbjct: 11 AIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAE 70
Query: 66 ALHSAVQSK----------------------------SADPLKSKHQLDLERAHFLVTQA 97
L +++K S DP K K Q L+ A +
Sbjct: 71 KLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPN 130
Query: 98 FDEDEKENVEDAIELYTEAVDLCLK 122
+ +E A E EAV L +K
Sbjct: 131 VKWSDVAGLEGAKEALKEAVILPIK 155
>gi|209915591 ribosomal protein S6 kinase, 52kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 1054
Score = 36.6 bits (83), Expect = 0.096
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 72 QSKSADPLKSKHQLD----LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYET 127
+S+S P K +L LE+A L+ A ++E+++ E A + Y + VDL L+
Sbjct: 209 ESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGE 268
Query: 128 ADKVLQNKLKQLARQALDRAEALSEPLTKP 157
+ + +K+ + L RAE++S KP
Sbjct: 269 SSPTRREAVKRRTAEYLMRAESISSLYGKP 298
>gi|19923723 ribosomal protein S6 kinase, 52kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 1066
Score = 36.6 bits (83), Expect = 0.096
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 72 QSKSADPLKSKHQLD----LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYET 127
+S+S P K +L LE+A L+ A ++E+++ E A + Y + VDL L+
Sbjct: 221 ESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGE 280
Query: 128 ADKVLQNKLKQLARQALDRAEALSEPLTKP 157
+ + +K+ + L RAE++S KP
Sbjct: 281 SSPTRREAVKRRTAEYLMRAESISSLYGKP 310
>gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens]
Length = 1012
Score = 34.7 bits (78), Expect = 0.36
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 7/109 (6%)
Query: 51 ENIQEKITEYLERVQALHSAVQSKSADPLKS---KHQLDLERAHFLVTQAFDEDEKENVE 107
E + ITE L R + + + LK+ K+QL+L+ + + T EDE++N E
Sbjct: 318 EEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKE 377
Query: 108 DAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTK 156
A+ L E + + K E V N++K+L + L+ +A S +TK
Sbjct: 378 KAVHLQEELIAINSKKE-ELNQSV--NRVKELELE-LESVKAQSLAITK 422
>gi|20270349 MIT, microtubule interacting and transport, domain
containing 1 [Homo sapiens]
Length = 249
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/71 (25%), Positives = 35/71 (49%), Gaps = 3/71 (4%)
Query: 10 AVQFARLAVQRDHEGRYSEAVFYYKEAAQALIY---AEMAGSSLENIQEKITEYLERVQA 66
A + AV+ D E RY +A+ Y+E L+ + N++EKI++Y++R +
Sbjct: 15 AATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAEN 74
Query: 67 LHSAVQSKSAD 77
+ + + D
Sbjct: 75 IKKYLDQEKED 85
Score = 30.4 bits (67), Expect = 6.9
Identities = 16/62 (25%), Positives = 31/62 (50%)
Query: 93 LVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSE 152
++ +A + D + A+ Y E +DL L+ T D + L++ + +DRAE + +
Sbjct: 18 VLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 77
Query: 153 PL 154
L
Sbjct: 78 YL 79
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/64 (31%), Positives = 32/64 (50%)
Query: 87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDR 146
L RA LV QA +D++ + A+ LY +A+D + + D + +K Q + R
Sbjct: 281 LGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSR 340
Query: 147 AEAL 150
AE L
Sbjct: 341 AEEL 344
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 32.7 bits (73), Expect = 1.4
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 7/78 (8%)
Query: 87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKT-----SYETADKVLQNKLKQLAR 141
+ + +FL+ +A D++E+ + ++ ++ VDL LK YE KVL+ +++Q +R
Sbjct: 1127 VHKENFLLARA--RDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSR 1184
Query: 142 QALDRAEALSEPLTKPVG 159
AEALS P G
Sbjct: 1185 VLGWVAEALSRSALLPPG 1202
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/120 (25%), Positives = 60/120 (50%), Gaps = 15/120 (12%)
Query: 32 YYKEAAQALIYAEMAGSSLENI----QEKITEYLER---VQALHSAVQSKSADPLKSKHQ 84
+ + QAL ++ G + + QE +E+LE ++ LHS ++ S+ L S
Sbjct: 2224 FLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 2283
Query: 85 LDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLK--TSYETADKVLQNKLKQLARQ 142
L LE+ + L ++ F E +ED I+ EAV C + +++ K L++ +K+ ++
Sbjct: 2284 LVLEKTNNL-SKKFKE-----MEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2337
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,193,544
Number of Sequences: 37866
Number of extensions: 1582059
Number of successful extensions: 3894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3748
Number of HSP's gapped (non-prelim): 154
length of query: 813
length of database: 18,247,518
effective HSP length: 111
effective length of query: 702
effective length of database: 14,044,392
effective search space: 9859163184
effective search space used: 9859163184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.