Guide to the Human Genome
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Search of human proteins with 74136023

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|74136023 delta-like 1 homolog [Homo sapiens]
         (383 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|74136023 delta-like 1 homolog [Homo sapiens]                       832   0.0  
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]                241   8e-64
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]                241   8e-64
gi|110735443 delta-like 1 [Homo sapiens]                              224   1e-58
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              216   4e-56
gi|4557679 jagged 1 precursor [Homo sapiens]                          203   2e-52
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               201   7e-52
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               198   8e-51
gi|24041035 notch 2 preproprotein [Homo sapiens]                      168   9e-42
gi|148833508 notch1 preproprotein [Homo sapiens]                      162   5e-40
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]    160   2e-39
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]   160   2e-39
gi|134244285 Notch homolog 3 [Homo sapiens]                           158   7e-39
gi|112420992 crumbs homolog 2 [Homo sapiens]                          157   2e-38
gi|148886654 polydom [Homo sapiens]                                   154   2e-37
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               150   2e-36
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 150   2e-36
gi|55770876 notch4 preproprotein [Homo sapiens]                       147   2e-35
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   143   3e-34
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     142   7e-34
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]    140   2e-33
gi|4759146 slit homolog 2 [Homo sapiens]                              135   5e-32
gi|188528675 slit homolog 1 [Homo sapiens]                            135   6e-32
gi|11321571 slit homolog 3 [Homo sapiens]                             125   5e-29
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]   117   1e-26
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               117   1e-26
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              115   5e-26
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           113   3e-25
gi|153946395 tenascin C precursor [Homo sapiens]                      110   2e-24
gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]               109   5e-24

>gi|74136023 delta-like 1 homolog [Homo sapiens]
          Length = 383

 Score =  832 bits (2149), Expect = 0.0
 Identities = 383/383 (100%), Positives = 383/383 (100%)

Query: 1   MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60
           MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
Sbjct: 1   MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60

Query: 61  PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 120
           PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
Sbjct: 61  PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 120

Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180
           GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
Sbjct: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180

Query: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240
           NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
Sbjct: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240

Query: 241 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 300
           GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
Sbjct: 241 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 300

Query: 301 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 360
           EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
Sbjct: 301 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 360

Query: 361 VNIIFPEKIDMTTFSKEAGDEEI 383
           VNIIFPEKIDMTTFSKEAGDEEI
Sbjct: 361 VNIIFPEKIDMTTFSKEAGDEEI 383


>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score =  241 bits (615), Expect = 8e-64
 Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)

Query: 7   LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66
           L+ +L +L A G      +C   C+  +G C  D  CRC PGW+G  C++CV  PGC HG
Sbjct: 10  LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69

Query: 67  LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
            C +P QCIC  GW G+ CD+D   C++ +PC N G C+    G Y C C PG+ G+DC+
Sbjct: 70  TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129

Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
           +K GPC   GSPC++GG C DD+G A + +C C  GF G  CE+  + C   PC N   C
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189

Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244
            D    F C CP GF  + C+  + +CAS PCQ G  C       ++CLC   + G TC 
Sbjct: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248

Query: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303
           +      P      P G   A  + P     P       +L++S+KE+ ++    L E  
Sbjct: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306

Query: 304 AICFTILGVLTSLVVLGTV 322
            +   + G LT+ +VL TV
Sbjct: 307 LVALVVFGALTAALVLATV 325


>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score =  241 bits (615), Expect = 8e-64
 Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)

Query: 7   LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66
           L+ +L +L A G      +C   C+  +G C  D  CRC PGW+G  C++CV  PGC HG
Sbjct: 10  LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69

Query: 67  LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
            C +P QCIC  GW G+ CD+D   C++ +PC N G C+    G Y C C PG+ G+DC+
Sbjct: 70  TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129

Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
           +K GPC   GSPC++GG C DD+G A + +C C  GF G  CE+  + C   PC N   C
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189

Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244
            D    F C CP GF  + C+  + +CAS PCQ G  C       ++CLC   + G TC 
Sbjct: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248

Query: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303
           +      P      P G   A  + P     P       +L++S+KE+ ++    L E  
Sbjct: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306

Query: 304 AICFTILGVLTSLVVLGTV 322
            +   + G LT+ +VL TV
Sbjct: 307 LVALVVFGALTAALVLATV 325


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  224 bits (571), Expect = 1e-58
 Identities = 102/249 (40%), Positives = 135/249 (54%), Gaps = 26/249 (10%)

Query: 16  AFGHSTYGAE------------------CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC 57
           AFGH T G                    C P C+ Q+GFC+    C+C+ GWQG  CD+C
Sbjct: 198 AFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDEC 257

Query: 58  VTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACS-SAPCANNGTCVSLDDGLYECSCA 116
           +  PGCLHG C +P QC C +GW G  C++D+  C+   PC N  TC +   G Y CSC 
Sbjct: 258 IRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317

Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
           PGY+G  C+     C  + SPC++GG+C D E   +  SC CPPGF G  CE+ A +C  
Sbjct: 318 PGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTCAD 372

Query: 177 NPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
            PC N G C+D   G + CRCP G+    C + +  C+SSPC NG  C+     +Y C C
Sbjct: 373 GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLCRC 431

Query: 236 KPEFTGLTC 244
           +  F+G  C
Sbjct: 432 QAGFSGRHC 440



 Score =  176 bits (446), Expect = 3e-44
 Identities = 84/233 (36%), Positives = 115/233 (49%), Gaps = 18/233 (7%)

Query: 22  YGAECFPACNPQNGF-----CEDDNVCRCQPGWQGPLCDQCVTSPGC--LHGLCGEPGQC 74
           YG  C   C P++       C +     C PGW+GP C + +  PGC   HG C +PG+C
Sbjct: 184 YGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGEC 243

Query: 75  ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
            C  GW G  CD     C   P   +GTC       ++C+C  G+ G  C +    C  +
Sbjct: 244 KCRVGWQGRYCDE----CIRYPGCLHGTCQQP----WQCNCQEGWGGLFCNQDLNYCT-H 294

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
             PC++G TC +  G+ S+ +C C PG++G  CE+  + C P+PC+N G CTD+   + C
Sbjct: 295 HKPCKNGATCTNT-GQGSY-TCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352

Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
            CP GF  K C      CA  PC NGG C       Y C C   ++G  C KK
Sbjct: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405



 Score =  162 bits (409), Expect = 6e-40
 Identities = 79/209 (37%), Positives = 101/209 (48%), Gaps = 13/209 (6%)

Query: 43  CRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
           C C+PG+ G  C    D+C  SP    G C +      C C  G+ G++C+     C+  
Sbjct: 314 CSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADG 373

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
           PC N G C    DG Y C C  GYSG +C+KK   C  + SPC +G  CVD         
Sbjct: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC--SSSPCSNGAKCVD---LGDAYL 428

Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
           C C  GFSG  C+   + C  +PC N G C D   DF C CP G+  + CS PV+ C  +
Sbjct: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHA 488

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           PC NG TC +     Y C C   + G  C
Sbjct: 489 PCHNGATCHERGH-RYVCECARGYGGPNC 516



 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 53/150 (35%), Positives = 73/150 (48%), Gaps = 19/150 (12%)

Query: 43  CRCQPGWQGPLC----DQCVTSPGCLHGL----CGEPGQCICTDGWDGELCDRDVRACSS 94
           CRC  G+ G  C    D C +SP C +G      G+   C C  G+ G  CD +V  C+S
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSP-CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS 449

Query: 95  APCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
           +PCAN GTC    DG+  + C+C PGY+G++C      C    +PC +G TC +   R  
Sbjct: 450 SPCANGGTC---RDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAPCHNGATCHE---RGH 501

Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCEND 182
              C C  G+ G  C+ +     P P   D
Sbjct: 502 RYVCECARGYGGPNCQFLLPELPPGPAVVD 531



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 39/108 (36%), Positives = 47/108 (43%), Gaps = 13/108 (12%)

Query: 39  DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRA 91
           D  +CRCQ G+ G  CD     C +SP    G C +      C C  G+ G  C   V  
Sbjct: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484

Query: 92  CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-----KKDGPCVIN 134
           C  APC N  TC       Y C CA GY G +CQ        GP V++
Sbjct: 485 CEHAPCHNGATCHERGHR-YVCECARGYGGPNCQFLLPELPPGPAVVD 531


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  216 bits (549), Expect = 4e-56
 Identities = 94/222 (42%), Positives = 123/222 (55%), Gaps = 9/222 (4%)

Query: 26  CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELC 85
           C   C+ QNG+C     C C+PGWQG LC++C+   GC HG C  P QC C +GW G  C
Sbjct: 222 CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFC 281

Query: 86  DRDVRACS-SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
           D+D+  C+  +PC N  TC +     Y C+C PGY+G DC+ +   C  + +PC++GG+C
Sbjct: 282 DQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC--DSNPCRNGGSC 339

Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD--IGGDFRCRCPAGFID 202
            D E       CLCPPG+ G  CE    SC  +PC N G C +   G ++ C CP  F  
Sbjct: 340 KDQE---DGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTG 396

Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             C + V  C S+PC NGG CL     S  C C+P FTG  C
Sbjct: 397 SNCEKKVDRCTSNPCANGGQCLNRGP-SRMCRCRPGFTGTYC 437



 Score =  123 bits (309), Expect = 2e-28
 Identities = 71/185 (38%), Positives = 89/185 (48%), Gaps = 19/185 (10%)

Query: 38  EDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQ-----CICTDGWDGELCDRD 88
           ED   C C PG+ G  C+     C  SP    G C E  Q     C C   + G  C++ 
Sbjct: 343 EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402

Query: 89  VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
           V  C+S PCAN G C++       C C PG++G  C+     C  N  PC HGGTC D E
Sbjct: 403 VDRCTSNPCANGGQCLNRGPSRM-CRCRPGFTGTYCELHVSDCARN--PCAHGGTCHDLE 459

Query: 149 GRASHASCLCPPGFSGNFCEI--VANSCTPNPCENDGVC-TDIGGD-FRCRCPAGFIDKT 204
              +   C CP GFSG  CE+    ++C  +PC N   C TD+  D F C CP GF+   
Sbjct: 460 ---NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSR 516

Query: 205 CSRPV 209
           C  PV
Sbjct: 517 CEFPV 521



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 55/162 (33%), Positives = 74/162 (45%), Gaps = 16/162 (9%)

Query: 19  HSTYGAECFPACNPQNGFCEDDN-----VCRCQPGWQGPLC----DQCVTSPGCLHGLC- 68
           HST      P  N   G C + N      C C P + G  C    D+C ++P    G C 
Sbjct: 361 HSTLSCADSPCFN--GGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418

Query: 69  --GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK 126
             G    C C  G+ G  C+  V  C+  PCA+ GTC  L++GL  C+C  G+SG+ C+ 
Sbjct: 419 NRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLM-CTCPAGFSGRRCEV 477

Query: 127 KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCE 168
           +        SPC +  TC  D    +   C CP GF G+ CE
Sbjct: 478 RTSIDACASSPCFNRATCYTDLSTDTFV-CNCPYGFVGSRCE 518


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  203 bits (516), Expect = 2e-52
 Identities = 87/222 (39%), Positives = 123/222 (55%), Gaps = 7/222 (3%)

Query: 24  AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
           A C   C+P++G C+    CRCQ GWQG  CD+C+  PGC+HG+C EP QC+C   W G+
Sbjct: 232 AICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQ 291

Query: 84  LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
           LCD+D+  C +  PC N GTC +     Y+CSC  GYSG +C+  +  C+    PC + G
Sbjct: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL--SDPCHNRG 349

Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
           +C +    +    C C PG++G  C    + C+PN C + G C D+   F+C CP  +  
Sbjct: 350 SCKE---TSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG 406

Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           KTC      C + PC N  +C ++   SY C C P + G  C
Sbjct: 407 KTCQLDANECEAKPCVNAKSC-KNLIASYYCDCLPGWMGQNC 447



 Score =  160 bits (404), Expect = 2e-39
 Identities = 88/269 (32%), Positives = 118/269 (43%), Gaps = 53/269 (19%)

Query: 22  YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLH-GLCGEPG---- 72
           Y  +C P     +G C +   C C+  W G LCD+    C T   CL+ G C   G    
Sbjct: 261 YCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320

Query: 73  QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
           QC C +G+ G  C+    AC S PC N G+C     G +EC C+PG++G  C      C 
Sbjct: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCS 379

Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-------------- 178
            N   C HGGTC D     +   C+CPP ++G  C++ AN C   P              
Sbjct: 380 PNN--CSHGGTCQD---LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY 434

Query: 179 -----------------------CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
                                  C+ND  C D+   +RC CP G+    C R +  CAS+
Sbjct: 435 YCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN 494

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           PC NGG C Q+    ++CLC   F+G  C
Sbjct: 495 PCLNGGHC-QNEINRFQCLCPTGFSGNLC 522



 Score =  150 bits (378), Expect = 2e-36
 Identities = 85/265 (32%), Positives = 114/265 (43%), Gaps = 58/265 (21%)

Query: 30  CNPQNGFCEDDN----VCRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTD 78
           C P +G C+  +     C C  G+ G  C +    C ++P    G C +     +CIC+D
Sbjct: 599 CGP-HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSD 657

Query: 79  GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
           GW+G  C+ ++  CS  PC N GTC  L +  Y C C  G+ GK C  +D  C  + + C
Sbjct: 658 GWEGAYCETNINDCSQNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQC--DEATC 714

Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANS------------------------- 173
            +GGTC D EG A    C+CP G+ G  C I  NS                         
Sbjct: 715 NNGGTCYD-EGDAF--KCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCK 771

Query: 174 --------------CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQN 219
                         C+P+PC N G C D    +RC C  GF    C   +  C SSPC  
Sbjct: 772 EGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAF 831

Query: 220 GGTCLQHTQVSYECLCKPEFTGLTC 244
           G TC+      Y C+C P  +G  C
Sbjct: 832 GATCVDEIN-GYRCVCPPGHSGAKC 855



 Score =  149 bits (375), Expect = 5e-36
 Identities = 74/221 (33%), Positives = 104/221 (47%), Gaps = 20/221 (9%)

Query: 35  GFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHG-LCGE---PGQCICTDGWDGE 83
           G C++ ++   C C PGW GP C    D C  +  C HG  C +     +C+C   W G+
Sbjct: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPN-NCSHGGTCQDLVNGFKCVCPPQWTGK 407

Query: 84  LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
            C  D   C + PC N  +C +L    Y C C PG+ G++C      C+     CQ+  +
Sbjct: 408 TCQLDANECEAKPCVNAKSCKNLIASYY-CDCLPGWMGQNCDININDCL---GQCQNDAS 463

Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
           C D     +   C+CPPG++G+ CE   + C  NPC N G C +    F+C CP GF   
Sbjct: 464 CRD---LVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520

Query: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C   +  C  +PCQNG  C       Y C C  ++ G  C
Sbjct: 521 LCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNC 560



 Score =  139 bits (350), Expect = 4e-33
 Identities = 72/210 (34%), Positives = 102/210 (48%), Gaps = 25/210 (11%)

Query: 30  CNPQN----GFCED---DNVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPGQ 73
           C+P N    G C+D      C C P W G  C           CV +  C + +      
Sbjct: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY--Y 435

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
           C C  GW G+ CD ++  C    C N+ +C  L +G Y C C PGY+G  C++    C  
Sbjct: 436 CDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCICPPGYAGDHCERDIDECAS 493

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
           N  PC +GG C ++  R     CLCP GFSGN C++  + C PNPC+N   C +   D+ 
Sbjct: 494 N--PCLNGGHCQNEINRFQ---CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548

Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
           C+CP  +  K CS    +C ++PC+   +C
Sbjct: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSC 578



 Score =  134 bits (338), Expect = 1e-31
 Identities = 73/230 (31%), Positives = 103/230 (44%), Gaps = 34/230 (14%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQCICTD 78
           GA+C+   +        D  C+C   ++G  C    D C T+P            C   D
Sbjct: 537 GAQCYNRAS--------DYFCKCPEDYEGKNCSHLKDHCRTTP------------CEVID 576

Query: 79  GWDGELCDRD----VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
                +   D    VR  SS  C  +G C S   G + C C  G++G  C +    C  N
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN 636

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
             PC++GGTC+D     +   C+C  G+ G +CE   N C+ NPC N G C D+  DF C
Sbjct: 637 --PCRNGGTCIDG---VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYC 691

Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C  G+  KTC    + C  + C NGGTC      +++C+C   + G TC
Sbjct: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD-AFKCMCPGGWEGTTC 740



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 60/192 (31%), Positives = 80/192 (41%), Gaps = 31/192 (16%)

Query: 24  AECFPACNPQNGFCE---DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPG---Q 73
           + C P      G C    +   C C+ GW+GP+C Q    C   P    G C +     +
Sbjct: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDG-PCV 132
           C C  G+ G  C  ++  C S+PCA   TCV   +G Y C C PG+SG  CQ+  G PC+
Sbjct: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCI 864

Query: 133 INGSPCQHGGTCVDD-------EGRASHASCLCPPG-----------FSGNFC-EIVANS 173
             GS    G    DD        GR + +   C P             SG  C  I+ + 
Sbjct: 865 TMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQ 924

Query: 174 CTPNPCENDGVC 185
           C  +PC   G C
Sbjct: 925 CFVHPCTGVGEC 936


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  201 bits (512), Expect = 7e-52
 Identities = 94/226 (41%), Positives = 120/226 (53%), Gaps = 8/226 (3%)

Query: 24  AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
           A C   CN  +G C     CRC  GWQG  CD+CV  PGC+HG C EP QC C   W G 
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGL 302

Query: 84  LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
           LCD+D+  C S  PC N GTC++ +   Y C+C  GYSG++C+K +  C  N  PC +GG
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGG 360

Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
           +C +     S   C CP G+SG  C +  + C  NPC   G C D    F C CP  ++ 
Sbjct: 361 SCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417

Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
            TC   V +C    CQ+GGTC       Y+C+C   F G  C  +R
Sbjct: 418 ATCQLDVNDCRGQ-CQHGGTCKDLVN-GYQCVCPRGFGGRHCELER 461



 Score =  154 bits (389), Expect = 1e-37
 Identities = 81/213 (38%), Positives = 99/213 (46%), Gaps = 21/213 (9%)

Query: 43  CRCQPGWQGPLCDQCVTSPG-CLHGLCGEPGQCI---------CTDGWDGELCDRDVRAC 92
           C C  GW+G LCD   T+P  CL   C   G+C          C DGW G+ C      C
Sbjct: 622 CFCPSGWEGELCD---TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 678

Query: 93  SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRA 151
            +  C+N GTC    D  + C+C PG+ G  C   K+  C+ N  PC +GGTCV   G  
Sbjct: 679 DAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSG 732

Query: 152 SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
           +  SC+C  G+ G  C    N C P PC N G+C D    FRC C  GF    C   +  
Sbjct: 733 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 792

Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           C SSPC  G TC+      Y C C P   G  C
Sbjct: 793 CQSSPCAYGATCVDEIN-GYRCSCPPGRAGPRC 824



 Score =  140 bits (354), Expect = 1e-33
 Identities = 84/255 (32%), Positives = 111/255 (43%), Gaps = 43/255 (16%)

Query: 25  ECFPACNPQNGFCED--DNV-CRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPG 72
           EC  +     G CED  D   C C  G+ GPLC    D C  SP C +G     L G+  
Sbjct: 463 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP-CRNGARCYNLEGDY- 520

Query: 73  QCICTDGWDGELCDRDVRAC-----------------------SSAPCANNGTCVSLDDG 109
            C C D + G+ C      C                       +S  C  +G CVS   G
Sbjct: 521 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 580

Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
            + C C  G++G  C +    C+  G PC++GGTC+D+        C CP G+ G  C+ 
Sbjct: 581 NFSCICDSGFTGTYCHENIDDCL--GQPCRNGGTCIDE---VDAFRCFCPSGWEGELCDT 635

Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
             N C P+PC + G C D+  DF C C  G+  KTC      C +  C NGGTC      
Sbjct: 636 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD- 694

Query: 230 SYECLCKPEFTGLTC 244
           ++ C C P + G TC
Sbjct: 695 TFRCACPPGWKGSTC 709



 Score =  127 bits (319), Expect = 2e-29
 Identities = 66/209 (31%), Positives = 93/209 (44%), Gaps = 37/209 (17%)

Query: 65  HGLCGEPGQCICTDGWDGELCDRDV-----------------------------RACSSA 95
           H  C + G   C DGW G+ C   V                               C   
Sbjct: 220 HYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPY 279

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
           P   +G+CV      ++C+C   + G  C K    C  +  PC +GGTC++ E       
Sbjct: 280 PGCVHGSCVE----PWQCNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAE--PDQYR 332

Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
           C CP G+SG  CE   ++CT NPC N G C ++   F C CP+G+   TC+  +  CAS+
Sbjct: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           PC  GGTC+      +EC+C  ++ G TC
Sbjct: 393 PCAAGGTCVDQVD-GFECICPEQWVGATC 420



 Score =  114 bits (285), Expect = 1e-25
 Identities = 69/213 (32%), Positives = 85/213 (39%), Gaps = 19/213 (8%)

Query: 25  ECFPACNPQNGFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QC 74
           +C P      G C D   D  C C  GW+G  C     QC        G C + G   +C
Sbjct: 639 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 698

Query: 75  ICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
            C  GW G  C      +C   PC N GTCV      + C C  G+ G+ C      C  
Sbjct: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG-SGASFSCICRDGWEGRTCTHNTNDC-- 755

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
           N  PC +GG CVD     +   C C PGF+G  C I  + C  +PC     C D    +R
Sbjct: 756 NPLPCYNGGICVDG---VNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812

Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
           C CP G     C   +    S  C + GT   H
Sbjct: 813 CSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPH 843


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  198 bits (503), Expect = 8e-51
 Identities = 90/222 (40%), Positives = 116/222 (52%), Gaps = 7/222 (3%)

Query: 24  AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
           A C   CN  +G C     CRC  GWQG  CD+CV  PGC+HG C EP QC C   W G 
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGL 302

Query: 84  LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
           LCD+D+  C S  PC N GTC++ +   Y C+C  GYSG++C+K +  C  N  PC +GG
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGG 360

Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
           +C +     S   C CP G+SG  C +  + C  NPC   G C D    F C CP  ++ 
Sbjct: 361 SCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417

Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            TC      C   PC N  +C ++    Y C C P + G+ C
Sbjct: 418 ATCQLDANECEGKPCLNAFSC-KNLIGGYYCDCIPGWKGINC 458



 Score =  167 bits (423), Expect = 1e-41
 Identities = 82/228 (35%), Positives = 105/228 (46%), Gaps = 15/228 (6%)

Query: 43  CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
           C C  GW GP C    D+C ++P    G C +     +CIC + W G  C  D   C   
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
           PC N  +C +L  G Y C C PG+ G +C      C      CQHGGTC D     +   
Sbjct: 431 PCLNAFSCKNLIGGYY-CDCIPGWKGINCHINVNDC---RGQCQHGGTCKD---LVNGYQ 483

Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
           C+CP GF G  CE+  + C  +PC + G+C D+   F C CP GF    C   V  C  S
Sbjct: 484 CVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS 543

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYG 263
           PC+NG  C  + +  Y C C  +F G  C   R   P    R+  G G
Sbjct: 544 PCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 590



 Score =  154 bits (389), Expect = 1e-37
 Identities = 81/213 (38%), Positives = 99/213 (46%), Gaps = 21/213 (9%)

Query: 43  CRCQPGWQGPLCDQCVTSPG-CLHGLCGEPGQCI---------CTDGWDGELCDRDVRAC 92
           C C  GW+G LCD   T+P  CL   C   G+C          C DGW G+ C      C
Sbjct: 660 CFCPSGWEGELCD---TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716

Query: 93  SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRA 151
            +  C+N GTC    D  + C+C PG+ G  C   K+  C+ N  PC +GGTCV   G  
Sbjct: 717 DAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSG 770

Query: 152 SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
           +  SC+C  G+ G  C    N C P PC N G+C D    FRC C  GF    C   +  
Sbjct: 771 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 830

Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           C SSPC  G TC+      Y C C P   G  C
Sbjct: 831 CQSSPCAYGATCVDEIN-GYRCSCPPGRAGPRC 862



 Score =  140 bits (354), Expect = 1e-33
 Identities = 84/255 (32%), Positives = 111/255 (43%), Gaps = 43/255 (16%)

Query: 25  ECFPACNPQNGFCED--DNV-CRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPG 72
           EC  +     G CED  D   C C  G+ GPLC    D C  SP C +G     L G+  
Sbjct: 501 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP-CRNGARCYNLEGDY- 558

Query: 73  QCICTDGWDGELCDRDVRAC-----------------------SSAPCANNGTCVSLDDG 109
            C C D + G+ C      C                       +S  C  +G CVS   G
Sbjct: 559 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618

Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
            + C C  G++G  C +    C+  G PC++GGTC+D+        C CP G+ G  C+ 
Sbjct: 619 NFSCICDSGFTGTYCHENIDDCL--GQPCRNGGTCIDE---VDAFRCFCPSGWEGELCDT 673

Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
             N C P+PC + G C D+  DF C C  G+  KTC      C +  C NGGTC      
Sbjct: 674 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD- 732

Query: 230 SYECLCKPEFTGLTC 244
           ++ C C P + G TC
Sbjct: 733 TFRCACPPGWKGSTC 747



 Score =  127 bits (319), Expect = 2e-29
 Identities = 66/209 (31%), Positives = 93/209 (44%), Gaps = 37/209 (17%)

Query: 65  HGLCGEPGQCICTDGWDGELCDRDV-----------------------------RACSSA 95
           H  C + G   C DGW G+ C   V                               C   
Sbjct: 220 HYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPY 279

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
           P   +G+CV      ++C+C   + G  C K    C  +  PC +GGTC++ E       
Sbjct: 280 PGCVHGSCVE----PWQCNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAE--PDQYR 332

Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
           C CP G+SG  CE   ++CT NPC N G C ++   F C CP+G+   TC+  +  CAS+
Sbjct: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           PC  GGTC+      +EC+C  ++ G TC
Sbjct: 393 PCAAGGTCVDQVD-GFECICPEQWVGATC 420



 Score =  114 bits (285), Expect = 1e-25
 Identities = 69/213 (32%), Positives = 85/213 (39%), Gaps = 19/213 (8%)

Query: 25  ECFPACNPQNGFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QC 74
           +C P      G C D   D  C C  GW+G  C     QC        G C + G   +C
Sbjct: 677 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736

Query: 75  ICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
            C  GW G  C      +C   PC N GTCV      + C C  G+ G+ C      C  
Sbjct: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG-SGASFSCICRDGWEGRTCTHNTNDC-- 793

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
           N  PC +GG CVD     +   C C PGF+G  C I  + C  +PC     C D    +R
Sbjct: 794 NPLPCYNGGICVDG---VNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 850

Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
           C CP G     C   +    S  C + GT   H
Sbjct: 851 CSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPH 881



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 51/162 (31%), Positives = 67/162 (41%), Gaps = 28/162 (17%)

Query: 94  SAPCANNGTCVSLDD--GLYEC------SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
           SA C  N  C   +D  G Y C      +C  G+ GK+C  K+  C   G    HGG  V
Sbjct: 204 SATC--NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC--KEAVCK-QGCNLLHGGCTV 258

Query: 146 DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
             E       C C  G+ G FC+     C P P    G C +    ++C C   +    C
Sbjct: 259 PGE-------CRCSYGWQGRFCD----ECVPYPGCVHGSCVE---PWQCNCETNWGGLLC 304

Query: 206 SRPVTNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
            + +  C S  PC NGGTC+      Y C C   ++G  C K
Sbjct: 305 DKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  168 bits (425), Expect = 9e-42
 Identities = 88/235 (37%), Positives = 115/235 (48%), Gaps = 23/235 (9%)

Query: 25   ECFPACNP--QNGFCEDD---NVCRCQPGWQGPLC---------DQCVTSPGCLHGLCGE 70
            EC  A NP    G C DD     C C   + G  C         + C  +  C      E
Sbjct: 798  EC--ASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFE 855

Query: 71   PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
               C+C  GW G+ C  D+  C S PC N+G C +   G Y C C PG+SG DC++    
Sbjct: 856  SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQ-GSYMCECPPGFSGMDCEEDIDD 914

Query: 131  CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
            C+ N  PCQ+GG+C+D     +  SCLC PGF+G+ C+   N C   PC+N G C+D   
Sbjct: 915  CLAN--PCQNGGSCMDG---VNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969

Query: 191  DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCV 245
             + C+C AGF    C   +  C  S C NGGTC+     S+ CLC   FTG  C+
Sbjct: 970  SYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGIN-SFSCLCPVGFTGSFCL 1023



 Score =  167 bits (422), Expect = 2e-41
 Identities = 86/232 (37%), Positives = 115/232 (49%), Gaps = 21/232 (9%)

Query: 25   ECFPACNPQNGFCEDDN---VCRCQPGWQGPLC----DQCVTSP-----GCLHGLCGEPG 72
            EC       +G C +     +C C PG+ G  C    D C+ +P      C+ G+     
Sbjct: 876  ECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGV--NTF 933

Query: 73   QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
             C+C  G+ G+ C  D+  C S PC N GTC    +  Y C C  G+ G  C+     C 
Sbjct: 934  SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNS-YTCKCQAGFDGVHCENNINECT 992

Query: 133  INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
               S C +GGTCVD     +  SCLCP GF+G+FC    N C+ +PC N+G C D  G +
Sbjct: 993  --ESSCFNGGTCVDG---INSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTY 1047

Query: 193  RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            RC CP G+  K C   V  C+ SPC+N GTC+Q    S +CLC   + G  C
Sbjct: 1048 RCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAES-QCLCPSGWAGAYC 1098



 Score =  162 bits (410), Expect = 5e-40
 Identities = 90/232 (38%), Positives = 114/232 (49%), Gaps = 22/232 (9%)

Query: 27  FPACNPQNGFCEDDNV---CRCQPGWQGPLC---DQCVTSPGCLHGLCGEP---GQCICT 77
           F +C P    C D      C C  G  G LC   D C+++P     LC      GQ ICT
Sbjct: 344 FASCTP-GSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICT 402

Query: 78  --DGWDGELCDRDVRACSSA---PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
              G+ G  C  DV  C+ A   PC + G CV+ D G + C C  GY+G  C+     C 
Sbjct: 403 CPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC- 460

Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
            +  PCQ+  TC+D  G  +   CLC PGF G  CE+  N C  NPC N+G C D    F
Sbjct: 461 -HSDPCQNDATCLDKIGGFT---CLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516

Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           +C CP GF    C   + +C+S+PC NG  C+ H    YEC C   FTG+ C
Sbjct: 517 QCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPN-GYECQCATGFTGVLC 567



 Score =  159 bits (402), Expect = 4e-39
 Identities = 92/266 (34%), Positives = 121/266 (45%), Gaps = 57/266 (21%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLC--GEPG-QCI 75
           GA C    N  NGF      C C  G   P C    ++C+++P C+HG C  G  G +C+
Sbjct: 694 GATCI---NGVNGFR-----CICPEGPHHPSCYSQVNECLSNP-CIHGNCTGGLSGYKCL 744

Query: 76  CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
           C  GW G  C+ D   C S PC N GTC +L +G Y C+C  G+ G +CQ     C  N 
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNG-YRCTCKKGFKGYNCQVNIDECASN- 802

Query: 136 SPCQHGGTCVDD-EGRASHA------------------------------------SCLC 158
            PC + GTC DD  G   H                                     +CLC
Sbjct: 803 -PCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLC 861

Query: 159 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
            PG+ G  C I  + C   PC N G+C +  G + C CP GF    C   + +C ++PCQ
Sbjct: 862 APGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQ 921

Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTC 244
           NGG+C+     ++ CLC P FTG  C
Sbjct: 922 NGGSCMDGVN-TFSCLCLPGFTGDKC 946



 Score =  152 bits (384), Expect = 5e-37
 Identities = 87/254 (34%), Positives = 116/254 (45%), Gaps = 22/254 (8%)

Query: 6   ALLRVLLLLLAFGHSTYGAECFPACNPQNGFC----EDDNVCRCQPGWQGPLC------- 54
           ALL + L   A  H+    + +  C    G C         C+C  G+ G  C       
Sbjct: 11  ALLALWLCCAAPAHALQCRDGYEPC-VNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCE 69

Query: 55  -DQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVR--ACSSAPCANNGTCVSLDDGLY 111
            ++C     C+         C C  G+ GE C          S PC N GTC  L    Y
Sbjct: 70  KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTY 129

Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
           EC+C  G++GK+CQ  D  C+ +  PC +G TC      A+  SC C  GF+G  CE   
Sbjct: 130 ECTCQVGFTGKECQWTDA-CLSH--PCANGSTCTTV---ANQFSCKCLTGFTGQKCETDV 183

Query: 172 NSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVS 230
           N C  P  C++ G C ++ G ++C+CP GF  + C      CA SPC NGGTC Q    +
Sbjct: 184 NECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT 243

Query: 231 YECLCKPEFTGLTC 244
           +EC C P F G TC
Sbjct: 244 FECNCLPGFEGSTC 257



 Score =  152 bits (384), Expect = 5e-37
 Identities = 79/215 (36%), Positives = 108/215 (50%), Gaps = 18/215 (8%)

Query: 43  CRCQPGWQGPLCDQ-----CVTSPGCLHG-----LCGEPGQCICTDGWDGELCDRDVRAC 92
           CRC  G+ G  C       C  S  CL+G     L  +  +C C  G+ G+ C     AC
Sbjct: 90  CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC 148

Query: 93  SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
            S PCAN  TC ++ +  + C C  G++G+ C+     C I G  CQHGGTC++  G   
Sbjct: 149 LSHPCANGSTCTTVANQ-FSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLNLPGSYQ 206

Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPVTN 211
              C CP GF+G +C+ +   C P+PC N G C   G   F C C  GF   TC R + +
Sbjct: 207 ---CQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDD 263

Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
           C +  CQNGG C+     +Y C C P++TG  C +
Sbjct: 264 CPNHRCQNGGVCVDGVN-TYNCRCPPQWTGQFCTE 297



 Score =  151 bits (382), Expect = 8e-37
 Identities = 80/230 (34%), Positives = 110/230 (47%), Gaps = 19/230 (8%)

Query: 25  ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEP---GQC 74
           EC+ +    +G C D      C CQPG  G  C    D C ++P C+HG+C +      C
Sbjct: 610 ECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP-CIHGICMDGINRYSC 668

Query: 75  ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
           +C+ G+ G+ C+ D+  C+S PC    TC++  +G + C C  G     C  +   C+ N
Sbjct: 669 VCSPGFTGQRCNIDIDECASNPCRKGATCINGVNG-FRCICPEGPHHPSCYSQVNECLSN 727

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
             PC HG       G  S   CLC  G+ G  CE+  N C  NPC+N G C ++   +RC
Sbjct: 728 --PCIHGNCT----GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRC 781

Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C  GF    C   +  CAS+PC N GTC       Y C C   +TG  C
Sbjct: 782 TCKKGFKGYNCQVNIDECASNPCLNQGTCFDDIS-GYTCHCVLPYTGKNC 830



 Score =  151 bits (381), Expect = 1e-36
 Identities = 87/277 (31%), Positives = 118/277 (42%), Gaps = 63/277 (22%)

Query: 25   ECFPACNPQNGFCED---DNVCRCQPGWQGPLCDQCV---TSPGCLHGLCGEPG----QC 74
            EC        G C D      C+CQ G+ G  C+  +   T   C +G     G     C
Sbjct: 952  ECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC 1011

Query: 75   ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCV 132
            +C  G+ G  C  ++  CSS PC N GTCV   DGL  Y CSC  GY+GK+CQ     C 
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCV---DGLGTYRCSCPLGYTGKNCQTLVNLC- 1067

Query: 133  INGSPCQHGGTCVDDEGRAS-----------------------------------HAS-- 155
             + SPC++ GTCV  +  +                                    H+   
Sbjct: 1068 -SRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVC 1126

Query: 156  --------CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
                    C CP G++G++CE   + C  NPC++   C+D  G +RC C  G+    C  
Sbjct: 1127 INAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEY 1186

Query: 208  PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             V  C + PCQNGGTC+      ++C C P   GL C
Sbjct: 1187 EVDECQNQPCQNGGTCIDLVN-HFKCSCPPGTRGLLC 1222



 Score =  148 bits (374), Expect = 7e-36
 Identities = 82/236 (34%), Positives = 108/236 (45%), Gaps = 31/236 (13%)

Query: 40   DNVCRCQPGWQGPLCDQCVTSPGC----------LHGLCGEPGQCI---------CTDGW 80
            ++ C C  GW G  CD  V +  C          +  LC   G CI         C  G+
Sbjct: 1084 ESQCLCPSGWAGAYCD--VPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY 1141

Query: 81   DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
             G  C+  +  C+S PC +  TC     G Y C C PGY G +C+ +   C     PCQ+
Sbjct: 1142 TGSYCEEQLDECASNPCQHGATCSDFIGG-YRCECVPGYQGVNCEYEVDEC--QNQPCQN 1198

Query: 141  GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-CENDGVCTDIGGDFRCRCPAG 199
            GGTC+D     +H  C CPPG  G  CE   + C   P C N G C D  G + CRC  G
Sbjct: 1199 GGTCID---LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPG 1255

Query: 200  FIDKTCSRPVTNCASSPCQNGGT--CLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
            F  + C   +  C S+PC + G+  C+Q T   Y C+C+  FTG  C     + PQ
Sbjct: 1256 FAGERCEGDINECLSNPCSSEGSLDCIQLTN-DYLCVCRSAFTGRHCETFVDVCPQ 1310



 Score =  146 bits (368), Expect = 3e-35
 Identities = 78/224 (34%), Positives = 104/224 (46%), Gaps = 22/224 (9%)

Query: 31  NPQNGFCEDDNVCRCQPGWQGPLC----DQCV--TSPGCLH-GLCGEPG---QCICTDGW 80
           NP NG      +C C  G++G  C    D+C    S  C H G C        C C  G+
Sbjct: 393 NPLNG----QYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY 448

Query: 81  DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
            G  C+ D+  C S PC N+ TC+    G + C C PG+ G  C+ +   C  N  PC +
Sbjct: 449 AGPRCEMDINECHSDPCQNDATCLDKIGG-FTCLCMPGFKGVHCELEINECQSN--PCVN 505

Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF 200
            G CVD   + +   CLCPPGF+G  C+I  + C+  PC N   C D    + C+C  GF
Sbjct: 506 NGQCVD---KVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGF 562

Query: 201 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
               C   + NC   PC +G    Q    SY C+C P + G  C
Sbjct: 563 TGVLCEENIDNCDPDPCHHGQ--CQDGIDSYTCICNPGYMGAIC 604



 Score =  145 bits (367), Expect = 5e-35
 Identities = 75/212 (35%), Positives = 103/212 (48%), Gaps = 16/212 (7%)

Query: 43  CRCQPGWQGPLCDQCVTS---PG-CLHG--LCGEPG--QCICTDGWDGELCDRDVRACSS 94
           C+C  G+ G  C+  V     PG C HG      PG  QC C  G+ G+ CD     C+ 
Sbjct: 168 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAP 227

Query: 95  APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
           +PC N GTC    D  +EC+C PG+ G  C++    C      CQ+GG CVD     +  
Sbjct: 228 SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDC--PNHRCQNGGVCVDG---VNTY 282

Query: 155 SCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
           +C CPP ++G FC    + C   PN C+N G C +  G + C C  G+    CS  + +C
Sbjct: 283 NCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDC 342

Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           A + C  G TC+     S+ C+C     GL C
Sbjct: 343 AFASCTPGSTCIDRV-ASFSCMCPEGKAGLLC 373



 Score =  144 bits (363), Expect = 1e-34
 Identities = 77/214 (35%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 43   CRCQPGWQGPLC----DQCVTSPGCLHGL-CGE---PGQCICTDGWDGELCDRDVRACSS 94
            C+C  G+ G  C    D+C ++P C HG  C +     +C C  G+ G  C+ +V  C +
Sbjct: 1135 CQCPLGYTGSYCEEQLDECASNP-CQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQN 1193

Query: 95   APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
             PC N GTC+ L +  ++CSC PG  G  C++    C   G  C +GG C+D   R    
Sbjct: 1194 QPCQNGGTCIDLVNH-FKCSCPPGTRGLLCEENIDDCA-RGPHCLNGGQCMD---RIGGY 1248

Query: 155  SCLCPPGFSGNFCEIVANSCTPNPCENDGV--CTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
            SC C PGF+G  CE   N C  NPC ++G   C  +  D+ C C + F  + C   V  C
Sbjct: 1249 SCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVC 1308

Query: 213  ASSPCQNGGTCLQHTQV--SYECLCKPEFTGLTC 244
               PC NGGTC   + +   + C C P F+G  C
Sbjct: 1309 PQMPCLNGGTCAVASNMPDGFICRCPPGFSGARC 1342



 Score =  143 bits (361), Expect = 2e-34
 Identities = 75/209 (35%), Positives = 108/209 (51%), Gaps = 16/209 (7%)

Query: 43  CRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
           C C PG++G  C+    +C ++P   +G C +     QC+C  G+ G +C  D+  CSS 
Sbjct: 480 CLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSST 539

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
           PC N   C+   +G YEC CA G++G  C++    C  +  PC HG  C D  G  S+ +
Sbjct: 540 PCLNGAKCIDHPNG-YECQCATGFTGVLCEENIDNC--DPDPCHHG-QCQD--GIDSY-T 592

Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
           C+C PG+ G  C    + C  +PC NDG C D+   ++C C  G     C     +CAS+
Sbjct: 593 CICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASN 652

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           PC + G C+      Y C+C P FTG  C
Sbjct: 653 PCIH-GICMDGIN-RYSCVCSPGFTGQRC 679



 Score =  137 bits (344), Expect = 2e-32
 Identities = 76/220 (34%), Positives = 97/220 (44%), Gaps = 25/220 (11%)

Query: 43   CRCQPGWQGPLCDQ----CVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSA 95
            C C  G+ G  C      C  SP    G C +     QC+C  GW G  CD    +C  A
Sbjct: 1049 CSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIA 1108

Query: 96   P----------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
                       C ++G C++  +  Y C C  GY+G  C+++   C  N  PCQHG TC 
Sbjct: 1109 ASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSYCEEQLDECASN--PCQHGATCS 1165

Query: 146  DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
            D  G      C C PG+ G  CE   + C   PC+N G C D+   F+C CP G     C
Sbjct: 1166 DFIGGYR---CECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLC 1222

Query: 206  SRPVTNCASSP-CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
               + +CA  P C NGG C+      Y C C P F G  C
Sbjct: 1223 EENIDDCARGPHCLNGGQCMDRIG-GYSCRCLPGFAGERC 1261



 Score =  130 bits (328), Expect = 2e-30
 Identities = 77/218 (35%), Positives = 101/218 (46%), Gaps = 33/218 (15%)

Query: 43   CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQCI---------CTDGWDGELCDRDV 89
            C C PG +G LC    D C   P CL+G     GQC+         C  G+ GE C+ D+
Sbjct: 1211 CSCPPGTRGLLCEENIDDCARGPHCLNG-----GQCMDRIGGYSCRCLPGFAGERCEGDI 1265

Query: 90   RACSSAPCANNGT--CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD 147
              C S PC++ G+  C+ L +  Y C C   ++G+ C+     C     PC +GGTC   
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCP--QMPCLNGGTCAVA 1322

Query: 148  EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
                    C CPPGFSG  C+   +SC    C     C       RC CP+    + C  
Sbjct: 1323 SNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPS---PRDCE- 1375

Query: 208  PVTNCASSPCQNGGTCLQHTQVS-YECLCKPEFTGLTC 244
              + CASSPCQ+GG+C    Q   Y C C P F+G  C
Sbjct: 1376 --SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRC 1411



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 54/203 (26%), Positives = 71/203 (34%), Gaps = 54/203 (26%)

Query: 23   GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD------QCVTSPGCLHGLCGEPGQCIC 76
            G  C  A N  +GF     +CRC PG+ G  C       +C     C+H   G   +C C
Sbjct: 1316 GGTCAVASNMPDGF-----ICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGP--RCFC 1368

Query: 77   TDGWDGELCDRDVRACSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
                D E        C+S+PC + G+C        Y C CAP +SG  C+    P     
Sbjct: 1369 PSPRDCE------SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAP----- 1417

Query: 136  SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCR 195
             P     TC+                    +C   A          DGVC +      C+
Sbjct: 1418 -PSTPPATCL------------------SQYCADKA---------RDGVCDEACNSHACQ 1449

Query: 196  CPAGFIDKTCSRPVTNCASS-PC 217
               G    T   P  NC+S  PC
Sbjct: 1450 WDGGDCSLTMENPWANCSSPLPC 1472


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  162 bits (410), Expect = 5e-40
 Identities = 78/221 (35%), Positives = 110/221 (49%), Gaps = 15/221 (6%)

Query: 34  NGFCEDD---NVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ---CICTDGWDGE 83
           +G C D      C C PGW G  CD    +C ++P    G C +      C C +G+ G 
Sbjct: 727 HGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGP 786

Query: 84  LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
            C  ++  C+S PC N GTC+  D   Y+C+C   Y+G  C+    PC    SPC++GG 
Sbjct: 787 NCQTNINECASNPCLNQGTCID-DVAGYKCNCLLPYTGATCEVVLAPCA--PSPCRNGGE 843

Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
           C   E   S  SC+CP G+ G  CE+  N C  +PC +   C +  G +RC C AG+  +
Sbjct: 844 CRQSEDYESF-SCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGR 902

Query: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C   + +C  +PC NGG+C      ++ C C P F G  C
Sbjct: 903 NCETDIDDCRPNPCHNGGSCTDGINTAF-CDCLPGFRGTFC 942



 Score =  162 bits (409), Expect = 6e-40
 Identities = 89/234 (38%), Positives = 110/234 (47%), Gaps = 23/234 (9%)

Query: 25   ECFPACNP--QNGFCEDDNV---CRCQPGWQGPLCD----QCVTSPGCLHGLCG-----E 70
            EC  A NP    G C DD     C C   + G  C+     C  SP    G C      E
Sbjct: 794  EC--ASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYE 851

Query: 71   PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
               C+C  GW G+ C+ D+  C  +PC +  +C +   G Y C C  GYSG++C+     
Sbjct: 852  SFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGG-YRCHCQAGYSGRNCETDIDD 910

Query: 131  CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
            C  N  PC +GG+C D     + A C C PGF G FCE   N C  +PC N   CTD   
Sbjct: 911  CRPN--PCHNGGSCTDG---INTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVD 965

Query: 191  DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             + C CPAGF    C     +C  S C NGGTC+     S+ CLC P FTG  C
Sbjct: 966  SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGIN-SFTCLCPPGFTGSYC 1018



 Score =  157 bits (397), Expect = 2e-38
 Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 25/239 (10%)

Query: 25   ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG----Q 73
            +C  +     G C D      C C PG+ G  C    ++C + P CLHG   + G    +
Sbjct: 986  DCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP-CLHGGTCQDGCGSYR 1044

Query: 74   CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
            C C  G+ G  C   V  C S+PC N G C       Y C C  G++G  C      C +
Sbjct: 1045 CTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ-YRCECPSGWTGLYCDVPSVSCEV 1103

Query: 134  NGSP--------CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
                        CQHGG CVD  G   H  C C  G++G++CE + + C+P+PC+N   C
Sbjct: 1104 AAQRQGVDVARLCQHGGLCVD-AGNTHH--CRCQAGYTGSYCEDLVDECSPSPCQNGATC 1160

Query: 186  TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            TD  G + C+C AG+    CS  +  C S PCQNGGTCL     +Y+C C     G+ C
Sbjct: 1161 TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPN-TYKCSCPRGTQGVHC 1218



 Score =  155 bits (391), Expect = 7e-38
 Identities = 81/234 (34%), Positives = 116/234 (49%), Gaps = 27/234 (11%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG---------Q 73
           G +C P         E   +C C P + GP C Q V   G   GLC   G         +
Sbjct: 152 GGQCLPF--------EASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYR 203

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
           C+C     G  C+R    CS +PC N GTC    D  +EC+C PG++G++C++    C  
Sbjct: 204 CVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDC-- 261

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGD 191
            G+ C++GG CVD     +  +C CPP ++G +C    + C   PN C+N G C +  G 
Sbjct: 262 PGNNCKNGGACVDG---VNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGG 318

Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
           + C C  G+  + CS  + +CAS+ C +G TC  H +V S+ C C    TGL C
Sbjct: 319 YNCVCVNGWTGEDCSENIDDCASAACFHGATC--HDRVASFYCECPHGRTGLLC 370



 Score =  154 bits (390), Expect = 1e-37
 Identities = 90/226 (39%), Positives = 110/226 (48%), Gaps = 22/226 (9%)

Query: 35  GFCEDDN---VCRCQPGWQGPLCDQ---CVTSPGCLHGLCGEPGQ-------CICTDGWD 81
           G CE  N    C C   + GP C     C+++P    G C    +       C C  G+ 
Sbjct: 35  GKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFS 94

Query: 82  GELCDRDV-RACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
           G LC   +  AC + PC N GTC  L    Y+C C PG+SGK CQ+ D PC  N  PC +
Sbjct: 95  GPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQAD-PCASN--PCAN 151

Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP--CENDGVCTDIGGDFRCRCPA 198
           GG C+  E  AS+  C CPP F G  C    N C   P  C + G C +  G +RC C A
Sbjct: 152 GGQCLPFE--ASYI-CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208

Query: 199 GFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
                 C RP   C+ SPCQNGGTC     V++EC C P FTG  C
Sbjct: 209 THTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNC 254



 Score =  152 bits (383), Expect = 6e-37
 Identities = 77/212 (36%), Positives = 105/212 (49%), Gaps = 17/212 (8%)

Query: 43  CRCQPGWQGPLC---DQCVTSP-----GCLHGLCGEPGQCICTDGWDGELCDRDVRACS- 93
           C C  G  G LC   D C+++P      C          C C  G+ G  C +DV  CS 
Sbjct: 359 CECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSL 418

Query: 94  -SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
            + PC + G C++   G +EC C  GY+G  C+     CV N  PCQ+  TC+D  G   
Sbjct: 419 GANPCEHAGKCINTL-GSFECQCLQGYTGPRCEIDVNECVSN--PCQNDATCLDQIGEFQ 475

Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
              C+C PG+ G  CE+  + C  +PC ++G C D   +F+C CP GF    C   V  C
Sbjct: 476 ---CICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDEC 532

Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           AS+PC+NG  CL     +Y C+C   +TG  C
Sbjct: 533 ASTPCKNGAKCLDGPN-TYTCVCTEGYTGTHC 563



 Score =  152 bits (383), Expect = 6e-37
 Identities = 85/236 (36%), Positives = 104/236 (44%), Gaps = 25/236 (10%)

Query: 24   AECFPACNPQNGFCEDDN-----VCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG-- 72
            A C P+     G C          C C  GWQG  C+    +CV SP C HG   +    
Sbjct: 831  APCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSP-CRHGASCQNTHG 889

Query: 73   --QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE--CSCAPGYSGKDCQKKD 128
              +C C  G+ G  C+ D+  C   PC N G+C    DG+    C C PG+ G  C++  
Sbjct: 890  GYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCT---DGINTAFCDCLPGFRGTFCEEDI 946

Query: 129  GPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI 188
              C     PC++G  C D        +C CP GFSG  CE     CT + C N G C D 
Sbjct: 947  NECA--SDPCRNGANCTDC---VDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDG 1001

Query: 189  GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
               F C CP GF    C   V  C S PC +GGTC Q    SY C C   +TG  C
Sbjct: 1002 INSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTC-QDGCGSYRCTCPQGYTGPNC 1056



 Score =  145 bits (367), Expect = 5e-35
 Identities = 79/229 (34%), Positives = 108/229 (47%), Gaps = 25/229 (10%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCI 75
           GA+C    N           C C  G+ G  C    D+C   P C +G C +      C+
Sbjct: 540 GAKCLDGPNTYT--------CVCTEGYTGTHCEVDIDECDPDP-CHYGSCKDGVATFTCL 590

Query: 76  CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
           C  G+ G  C+ ++  CSS PC + GTC   D+  Y C C  G +G +C+     C    
Sbjct: 591 CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNA-YLCFCLKGTTGPNCEINLDDCA--S 647

Query: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCR 195
           SPC   GTC+D   +     C C PG++G+ C I  + C  NPC N G C D    F CR
Sbjct: 648 SPCD-SGTCLD---KIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCR 703

Query: 196 CPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           CP G+ D TC   V  C S+PC +G    + +   Y+C C P ++G  C
Sbjct: 704 CPEGYHDPTCLSEVNECNSNPCVHG--ACRDSLNGYKCDCDPGWSGTNC 750



 Score =  144 bits (364), Expect = 1e-34
 Identities = 73/223 (32%), Positives = 99/223 (44%), Gaps = 21/223 (9%)

Query: 31  NPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI---------CTDGWD 81
           NP NG      +C C  G+ GP C Q V         C   G+CI         C  G+ 
Sbjct: 390 NPVNGKA----ICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT 445

Query: 82  GELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHG 141
           G  C+ DV  C S PC N+ TC+    G ++C C PGY G  C+     C    SPC H 
Sbjct: 446 GPRCEIDVNECVSNPCQNDATCLD-QIGEFQCICMPGYEGVHCEVNTDECA--SSPCLHN 502

Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFI 201
           G C+D   + +   C CP GF+G+ C+   + C   PC+N   C D    + C C  G+ 
Sbjct: 503 GRCLD---KINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYT 559

Query: 202 DKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
              C   +  C   PC  G    +    ++ CLC+P +TG  C
Sbjct: 560 GTHCEVDIDECDPDPCHYGS--CKDGVATFTCLCRPGYTGHHC 600



 Score =  142 bits (357), Expect = 7e-34
 Identities = 73/217 (33%), Positives = 103/217 (47%), Gaps = 16/217 (7%)

Query: 40  DNVCRCQPGWQGPLC-----DQCVTSPGCLHGLCG----EPGQCICTDGWDGELCDRDVR 90
           D  C C  G+ GPLC     + C+T+P    G C        +C C  GW G+ C +   
Sbjct: 84  DYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-AD 142

Query: 91  ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGR 150
            C+S PCAN G C+  +   Y C C P + G  C++    C      C+HGGTC ++ G 
Sbjct: 143 PCASNPCANGGQCLPFEAS-YICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGS 201

Query: 151 ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPV 209
                C+C    +G  CE     C+P+PC+N G C   G     C C  GF  + C   +
Sbjct: 202 YR---CVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENI 258

Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
            +C  + C+NGG C+     +Y C C PE+TG  C +
Sbjct: 259 DDCPGNNCKNGGACVDGVN-TYNCRCPPEWTGQYCTE 294



 Score =  120 bits (301), Expect = 2e-27
 Identities = 82/244 (33%), Positives = 100/244 (40%), Gaps = 28/244 (11%)

Query: 25   ECFPACNPQNGFCED---DNVCRCQPGWQGPLC-----------DQCVTSPGCLH-GLCG 69
            EC        G C D      C C  G QG  C           D    SP C + G C 
Sbjct: 1186 ECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCV 1245

Query: 70   EPG---QCICTDGWDGELCDRDVRACSSAPCANNGT--CVSLDDGLYECSCAPGYSGKDC 124
            +      C C  G+ GE C+ DV  C S PC   GT  CV   +  + C C  G++G+ C
Sbjct: 1246 DQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVND-FHCECRAGHTGRRC 1304

Query: 125  QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGV 184
            +     C   G PC++GGTC      A    C CP GF G  CE  A +C    C N G 
Sbjct: 1305 ESVINGC--KGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGT 1362

Query: 185  CTDIGGDFRCRCPAGFIDKTCSRPVTN--CASSPCQNGGTCLQHTQVS--YECLCKPEFT 240
            C        C C   F    C  P ++     +PC N GTC + T  S  Y CLC  +F 
Sbjct: 1363 CISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTC-EPTSESPFYRCLCPAKFN 1421

Query: 241  GLTC 244
            GL C
Sbjct: 1422 GLLC 1425



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 57/210 (27%), Positives = 80/210 (38%), Gaps = 38/210 (18%)

Query: 39   DDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI------------CTDGWDGELCD 86
            +D  C C+ G  G  C+  +   GC    C   G C             C  G++G  C+
Sbjct: 1289 NDFHCECRAGHTGRRCESVIN--GCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCE 1346

Query: 87   RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCV 145
             D R C S  C N GTC+S       C C   ++G +CQ     PC + G+PC + GTC 
Sbjct: 1347 NDARTCGSLRCLNGGTCIS-GPRSPTCLCLGPFTGPECQFPASSPC-LGGNPCYNQGTC- 1403

Query: 146  DDEGRASHASCLCPPGFSGNFCEI-----------------VANSCTPNPCENDG---VC 185
            +    +    CLCP  F+G  C I                 +  +C    C+ D    VC
Sbjct: 1404 EPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVC 1463

Query: 186  TDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
            +    +  C    G      + P  NC  S
Sbjct: 1464 SLQCNNHACGWDGGDCSLNFNDPWKNCTQS 1493



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 4/70 (5%)

Query: 179 CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL---QHTQVSYECLC 235
           C N G C    G   C C   F+   C  P   C S+PC+N GTC    +     Y C C
Sbjct: 31  CLNGGKCEAANGTEACVCGGAFVGPRCQDP-NPCLSTPCKNAGTCHVVDRRGVADYACSC 89

Query: 236 KPEFTGLTCV 245
              F+G  C+
Sbjct: 90  ALGFSGPLCL 99


>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
          Length = 618

 Score =  160 bits (404), Expect = 2e-39
 Identities = 88/268 (32%), Positives = 117/268 (43%), Gaps = 42/268 (15%)

Query: 26  CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-------------------- 65
           C   C+P++GFCE    CRC  GW GPLC   V++  CL                     
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279

Query: 66  -------GLCGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCV--SLDDGLYEC 113
                  G C E     +C C  G+ G  C+     C+  PC N G CV  +  D  Y C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339

Query: 114 SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEIVAN 172
            C PG+ G +C+K+   C +   PC++GG C+D      HA  C C  GF+G  CE   +
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQ--PCRNGGLCLD----LGHALRCRCRAGFAGPRCEHDLD 393

Query: 173 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
            C    C N G C + GG  RC C  GF  + C      CA+ PC +GG C  H      
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS-GLV 452

Query: 233 CLCKPEFTGLTCVKKRALSPQQVTRLPS 260
           C C P + G  C  +  + P   + LP+
Sbjct: 453 CACAPGYMGARC--EFPVHPDGASALPA 478



 Score =  154 bits (390), Expect = 1e-37
 Identities = 88/253 (34%), Positives = 112/253 (44%), Gaps = 41/253 (16%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQ--GPLCDQC----VTSPGCL--HGLCGEPGQC 74
           G  C   C P++         RC PG +   PL D+C    V   GC   HG C +PG+C
Sbjct: 184 GTACTRLCRPRSA------PSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGEC 237

Query: 75  ICTDGWDGELCDRDVRA-----------------------CSSAPCANNGTCVSLDDGLY 111
            C +GW G LC   V                         C   PCAN G+C S     +
Sbjct: 238 RCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC-SETPRSF 296

Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
           EC+C  G+ G  C+     C     PC +GG CV      S   C CPPGF G+ CE   
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCA--DGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354

Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
           + C+  PC N G+C D+G   RCRC AGF    C   + +CA   C NGGTC++    ++
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG-AH 413

Query: 232 ECLCKPEFTGLTC 244
            C C   F G  C
Sbjct: 414 RCSCALGFGGRDC 426


>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
          Length = 587

 Score =  160 bits (404), Expect = 2e-39
 Identities = 88/268 (32%), Positives = 117/268 (43%), Gaps = 42/268 (15%)

Query: 26  CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-------------------- 65
           C   C+P++GFCE    CRC  GW GPLC   V++  CL                     
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279

Query: 66  -------GLCGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCV--SLDDGLYEC 113
                  G C E     +C C  G+ G  C+     C+  PC N G CV  +  D  Y C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339

Query: 114 SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEIVAN 172
            C PG+ G +C+K+   C +   PC++GG C+D      HA  C C  GF+G  CE   +
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQ--PCRNGGLCLD----LGHALRCRCRAGFAGPRCEHDLD 393

Query: 173 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
            C    C N G C + GG  RC C  GF  + C      CA+ PC +GG C  H      
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS-GLV 452

Query: 233 CLCKPEFTGLTCVKKRALSPQQVTRLPS 260
           C C P + G  C  +  + P   + LP+
Sbjct: 453 CACAPGYMGARC--EFPVHPDGASALPA 478



 Score =  154 bits (390), Expect = 1e-37
 Identities = 88/253 (34%), Positives = 112/253 (44%), Gaps = 41/253 (16%)

Query: 23  GAECFPACNPQNGFCEDDNVCRCQPGWQ--GPLCDQC----VTSPGCL--HGLCGEPGQC 74
           G  C   C P++         RC PG +   PL D+C    V   GC   HG C +PG+C
Sbjct: 184 GTACTRLCRPRSA------PSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGEC 237

Query: 75  ICTDGWDGELCDRDVRA-----------------------CSSAPCANNGTCVSLDDGLY 111
            C +GW G LC   V                         C   PCAN G+C S     +
Sbjct: 238 RCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC-SETPRSF 296

Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
           EC+C  G+ G  C+     C     PC +GG CV      S   C CPPGF G+ CE   
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCA--DGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354

Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
           + C+  PC N G+C D+G   RCRC AGF    C   + +CA   C NGGTC++    ++
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG-AH 413

Query: 232 ECLCKPEFTGLTC 244
            C C   F G  C
Sbjct: 414 RCSCALGFGGRDC 426


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  158 bits (400), Expect = 7e-39
 Identities = 87/236 (36%), Positives = 117/236 (49%), Gaps = 23/236 (9%)

Query: 25  ECFPACNPQNGFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PG--QC 74
           EC  +   + G C D      C C PG   PLC      C   P C HG+C + PG  +C
Sbjct: 660 ECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEP-CSHGICYDAPGGFRC 718

Query: 75  ICTDGWDGELCDRDVR--ACSSAPCANNGTCVSLDDGL-YECSCAPGYSGKDCQKKDGPC 131
           +C  GW G  C + +   AC S PC   GTC S  DG+ + C+C PG  G+ C+    PC
Sbjct: 719 VCEPGWSGPRCSQSLARDACESQPCRAGGTCSS--DGMGFHCTCPPGVQGRQCELLS-PC 775

Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT-PNPCENDGVCTDIGG 190
             N  PC+HGG C    G+     C CP G+ G  C+   + C  P PC   G+CT++ G
Sbjct: 776 TPN--PCEHGGRCESAPGQLP--VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAG 831

Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
            F C C  G+   +C + + +C  +PC NGG+C Q    S+ C C P F G  C +
Sbjct: 832 SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPRCAR 886



 Score =  155 bits (392), Expect = 6e-38
 Identities = 88/251 (35%), Positives = 111/251 (44%), Gaps = 22/251 (8%)

Query: 12  LLLLAFGHSTYGAECFPACNPQNG-----FCEDDNVCRCQPGWQGPLC---DQCVTSPGC 63
           LLLL  G       C       NG         +  C C PGW G  C   D C + P  
Sbjct: 29  LLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCA 88

Query: 64  LHGLCGEPG-------QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA 116
             G+C            C C  G+ G  C      C S+PCA+   C    DG + CSC 
Sbjct: 89  GRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCP 147

Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
           PGY G+ C+     C + G PC+HGGTC++  G      C CP G++G  CE  A  C P
Sbjct: 148 PGYQGRSCRSDVDECRV-GEPCRHGGTCLNTPGSFR---CQCPAGYTGPLCENPAVPCAP 203

Query: 177 NPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
           +PC N G C   G   + C C  GF  + C   V +C    C NGGTC+     +Y C C
Sbjct: 204 SPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN-TYNCQC 262

Query: 236 KPEFTGLTCVK 246
            PE+TG  C +
Sbjct: 263 PPEWTGQFCTE 273



 Score =  154 bits (389), Expect = 1e-37
 Identities = 81/212 (38%), Positives = 108/212 (50%), Gaps = 17/212 (8%)

Query: 43  CRCQPGWQGPLC---DQCVTSPGCLHGLCGEP---GQCICT--DGWDGELCDRDVRACS- 93
           C C  G  G LC   D CV++P     +C      G+ ICT   G+ G  CD+DV  CS 
Sbjct: 338 CACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSI 397

Query: 94  -SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
            + PC + G CV+   G + C C  GY+G  C+     C+    PC++  TC+D   R  
Sbjct: 398 GANPCEHLGRCVNTQ-GSFLCQCGRGYTGPRCETDVNECL--SGPCRNQATCLD---RIG 451

Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
             +C+C  GF+G +CE+  + C  +PC N GVC D    F C CP+GF   TC   V  C
Sbjct: 452 QFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC 511

Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           AS+PC+NG  C+      YEC C   F G  C
Sbjct: 512 ASTPCRNGAKCVDQPD-GYECRCAEGFEGTLC 542



 Score =  153 bits (387), Expect = 2e-37
 Identities = 84/234 (35%), Positives = 118/234 (50%), Gaps = 25/234 (10%)

Query: 22  YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHG--LCGEPG--Q 73
           +GA C  +  P   F     +C C PG+QG  C    D+C     C HG      PG  +
Sbjct: 130 HGARC--SVGPDGRF-----LCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR 182

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
           C C  G+ G LC+     C+ +PC N GTC    D  Y+C+C PG+ G++C+     C  
Sbjct: 183 CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC-- 240

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGD 191
            G  C +GGTCVD     +  +C CPP ++G FC    + C   PN C N G C +  G 
Sbjct: 241 PGHRCLNGGTCVDG---VNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGG 297

Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
             C C  G+  ++CS+ + +CA++ C +G TC  H +V S+ C C    TGL C
Sbjct: 298 HSCVCVNGWTGESCSQNIDDCATAVCFHGATC--HDRVASFYCACPMGKTGLLC 349



 Score =  150 bits (380), Expect = 1e-36
 Identities = 79/223 (35%), Positives = 103/223 (46%), Gaps = 21/223 (9%)

Query: 31  NPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI---------CTDGWD 81
           NP NG      +C C PG+ G  CDQ V         C   G+C+         C  G+ 
Sbjct: 369 NPVNGRA----ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424

Query: 82  GELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHG 141
           G  C+ DV  C S PC N  TC+    G + C C  G++G  C+     C    SPC +G
Sbjct: 425 GPRCETDVNECLSGPCRNQATCLDRI-GQFTCICMAGFTGTYCEVDIDEC--QSSPCVNG 481

Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFI 201
           G C D   R +  SC CP GFSG+ C++  + C   PC N   C D    + CRC  GF 
Sbjct: 482 GVCKD---RVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE 538

Query: 202 DKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
              C R V +C+  PC + G C+     S+ C C P +TG  C
Sbjct: 539 GTLCDRNVDDCSPDPCHH-GRCVDGI-ASFSCACAPGYTGTRC 579



 Score =  150 bits (379), Expect = 2e-36
 Identities = 88/266 (33%), Positives = 111/266 (41%), Gaps = 54/266 (20%)

Query: 26   CFPACNPQNGFCEDDN----VCRCQPGWQGPLC----DQCVTSPGC-LHGLCGEPG---Q 73
            C P      G CE       VC C  GWQGP C    D+C     C  HG+C        
Sbjct: 775  CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFS 834

Query: 74   CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
            C C  G+ G  CD+D+  C   PC N G+C     G + CSC PG++G  C +    C+ 
Sbjct: 835  CTCHGGYTGPSCDQDINDCDPNPCLNGGSCQD-GVGSFSCSCLPGFAGPRCARDVDECLS 893

Query: 134  NG-----------------------------------SPCQHGGTCVDDEGRASHASCLC 158
            N                                    S C +GGTCVD     +  SCLC
Sbjct: 894  NPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDG---VNSFSCLC 950

Query: 159  PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
             PG++G  C+  A+ C   PC + GVC+     FRC C   F    C   V  C+  PCQ
Sbjct: 951  RPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQ 1010

Query: 219  NGGTCLQHTQVSYECLCKPEFTGLTC 244
            NGG C+   Q    CLC P ++G  C
Sbjct: 1011 NGGRCV---QTGAYCLCPPGWSGRLC 1033



 Score =  149 bits (377), Expect = 3e-36
 Identities = 88/239 (36%), Positives = 116/239 (48%), Gaps = 27/239 (11%)

Query: 25   ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHG-LCG--EPG-Q 73
            +C P+     G C D      C C+PG+ G  C    D C++ P CLHG +C    PG +
Sbjct: 927  DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRP-CLHGGVCSAAHPGFR 985

Query: 74   CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC-- 131
            C C + + G  C   V  CS  PC N G CV    G Y C C PG+SG+ C  +  PC  
Sbjct: 986  CTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAY-CLCPPGWSGRLCDIRSLPCRE 1042

Query: 132  ------VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
                  V     CQ GG CVD++  +SH  C+CP G +G+ CE   + C   PC++ G C
Sbjct: 1043 AAAQIGVRLEQLCQAGGQCVDED--SSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099

Query: 186  TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
                G + C C  G+    C   V  CAS PCQ+GG+C+      Y C C P   G+ C
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCID-LVARYLCSCPPGTLGVLC 1157



 Score =  140 bits (353), Expect = 2e-33
 Identities = 84/272 (30%), Positives = 123/272 (45%), Gaps = 56/272 (20%)

Query: 25  ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGL--CGEPG--Q 73
           EC  +     G C+D      C C  G+ G  C    D+C ++P C +G     +P   +
Sbjct: 472 ECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTP-CRNGAKCVDQPDGYE 530

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPC 131
           C C +G++G LCDR+V  CS  PC ++G CV   DG+  + C+CAPGY+G  C+ +   C
Sbjct: 531 CRCAEGFEGTLCDRNVDDCSPDPC-HHGRCV---DGIASFSCACAPGYTGTRCESQVDEC 586

Query: 132 VINGSPCQHGGTCVD----------------------DEGRASHAS------------CL 157
                PC+HGG C+D                      D+  ++  +            C+
Sbjct: 587 --RSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCV 644

Query: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
           C PGF+G  C +  N C  +PC   G C D    FRC CP G +   C  P   CA  PC
Sbjct: 645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC 704

Query: 218 QNGGTCLQHTQVSYECLCKPEFTGLTCVKKRA 249
            +G          + C+C+P ++G  C +  A
Sbjct: 705 SHG--ICYDAPGGFRCVCEPGWSGPRCSQSLA 734



 Score =  138 bits (348), Expect = 7e-33
 Identities = 86/273 (31%), Positives = 109/273 (39%), Gaps = 79/273 (28%)

Query: 43   CRCQPGWQGPLCDQCVTSPGC----------LHGLCGEPGQCI---------CTDGWDGE 83
            C C PGW G LCD  + S  C          L  LC   GQC+         C +G  G 
Sbjct: 1022 CLCPPGWSGRLCD--IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGS 1079

Query: 84   LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
             C+++V  C + PC + GTC     G Y C C PGY+G +C+     C     PCQHGG+
Sbjct: 1080 HCEQEVDPCLAQPCQHGGTCRGYMGG-YMCECLPGYNGDNCEDDVDECA--SQPCQHGGS 1136

Query: 144  CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-------CENDGVCTDI-------- 188
            C+D   R     C CPPG  G  CEI  + C P P       C ++G C D+        
Sbjct: 1137 CIDLVARYL---CSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193

Query: 189  ---------------------------------GGDFRCRCPAGFIDKTCSRPVTNCASS 215
                                             GG FRC C AGF    C   ++ C S 
Sbjct: 1194 PPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQ 1253

Query: 216  PCQNGGTCLQHT----QVSYECLCKPEFTGLTC 244
            PCQ+GG C         +++ C C   F G  C
Sbjct: 1254 PCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRC 1286



 Score =  133 bits (334), Expect = 3e-31
 Identities = 74/224 (33%), Positives = 96/224 (42%), Gaps = 29/224 (12%)

Query: 43   CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQ-CICTDGWDGELCDRDVRACSSAP- 96
            C C   + GP C    D C   P    G C + G  C+C  GW G LCD     C  A  
Sbjct: 986  CTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAA 1045

Query: 97   ---------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD 147
                     C   G CV  D   Y C C  G +G  C+++  PC+    PCQHGGTC   
Sbjct: 1046 QIGVRLEQLCQAGGQCVDEDSSHY-CVCPEGRTGSHCEQEVDPCL--AQPCQHGGTC--- 1099

Query: 148  EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
             G      C C PG++G+ CE   + C   PC++ G C D+   + C CP G +   C  
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159

Query: 208  PVTNCASSP-------CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
               +C   P       C + GTC+      + C C P +TGL C
Sbjct: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRC 1202



 Score =  127 bits (320), Expect = 1e-29
 Identities = 76/251 (30%), Positives = 111/251 (44%), Gaps = 54/251 (21%)

Query: 43  CRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSS 94
           C+C  G+ GPLC+     C  SP    G C + G     C C  G++G+ C+ +V  C  
Sbjct: 183 CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG 242

Query: 95  APCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC-------- 144
             C N GTCV   DG+  Y C C P ++G+ C +    C +  + C +GGTC        
Sbjct: 243 HRCLNGGTCV---DGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299

Query: 145 ---------------VDD------------EGRASHASCLCPPGFSGNFCEIVANSCTPN 177
                          +DD              R +   C CP G +G  C +  ++C  N
Sbjct: 300 CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHL-DDACVSN 358

Query: 178 PCENDGVC--TDIGGDFRCRCPAGFIDKTCSRPVTNCA--SSPCQNGGTCLQHTQVSYEC 233
           PC  D +C    + G   C CP GF    C + V  C+  ++PC++ G C+ +TQ S+ C
Sbjct: 359 PCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV-NTQGSFLC 417

Query: 234 LCKPEFTGLTC 244
            C   +TG  C
Sbjct: 418 QCGRGYTGPRC 428



 Score =  118 bits (295), Expect = 1e-26
 Identities = 84/271 (30%), Positives = 104/271 (38%), Gaps = 52/271 (19%)

Query: 22   YGAECFPACNPQNGFCEDD---------------------NVCRCQPGWQGPLC----DQ 56
            Y  EC P  N  N  CEDD                      +C C PG  G LC    D 
Sbjct: 1106 YMCECLPGYNGDN--CEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDD 1163

Query: 57   CV------TSPGCLH-GLCGE---PGQCICTDGWDGELCDRDVRACSSAPC--ANNGTCV 104
            C       + P CLH G C +     +C C  G+ G  C+ D+  C S  C  A+   C+
Sbjct: 1164 CGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCL 1223

Query: 105  SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGF 162
                G + C C  G+SG  CQ    PC     PCQHGG C    G     +  C C   F
Sbjct: 1224 QDPGGGFRCLCHAGFSGPRCQTVLSPC--ESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF 1281

Query: 163  SGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC--------SRPVTNCAS 214
             G  CE VA SC    C     C       RC CP G    +C             +CA+
Sbjct: 1282 WGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAA 1341

Query: 215  SPCQNGGTCLQHTQVS-YECLCKPEFTGLTC 244
            +PC +GG+C        + C C   +TG  C
Sbjct: 1342 APCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 49/196 (25%), Positives = 67/196 (34%), Gaps = 42/196 (21%)

Query: 22   YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEP--GQCICTDG 79
            +G  C PA  P   F      C C  GW GP C+    +P     +  EP   +  C   
Sbjct: 1346 HGGSCRPA--PLAPFFR----CACAQGWTGPRCE----APAAAPEVSEEPRCPRAACQAK 1395

Query: 80   WDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQ 139
               + CDR+   C+S  C  +G          +CS + G   + C+      + N S C 
Sbjct: 1396 RGDQRCDRE---CNSPGCGWDGG---------DCSLSVGDPWRQCEALQCWRLFNNSRCD 1443

Query: 140  HGGTCVDDEGRASHASCLCPPGFSGNF-CEIVANSCTPNPCENDGVCTDIGGDFRCRCPA 198
                           +C  P     NF C       T NP   +  C D   D   RC  
Sbjct: 1444 --------------PACSSPACLYDNFDCHAGGRERTCNPV-YEKYCADHFAD--GRCDQ 1486

Query: 199  GFIDKTCSRPVTNCAS 214
            G   + C     +CAS
Sbjct: 1487 GCNTEECGWDGLDCAS 1502


>gi|112420992 crumbs homolog 2 [Homo sapiens]
          Length = 1285

 Score =  157 bits (396), Expect = 2e-38
 Identities = 89/249 (35%), Positives = 115/249 (46%), Gaps = 33/249 (13%)

Query: 25  ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQC 74
           EC  A     G C D      C C PG+ G  C    D+C + P    G C +     +C
Sbjct: 149 ECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRC 208

Query: 75  ICTD-GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
            C   G++G  C+R+V  C+SAPC +N +C+    G + C C PGYSG+ C+  +  C  
Sbjct: 209 DCAGTGYEGTHCEREVLECASAPCEHNASCLE-GLGSFRCLCWPGYSGELCEVDEDECA- 266

Query: 134 NGSPCQHGGTCVDDEGRA---------------SHAS---CLCPPGFSGNFCEIVANSCT 175
             SPCQHGG C+     A                HA+   C CPPGF G  C +  + C 
Sbjct: 267 -SSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECA 325

Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
             PC N G C D+   F+C CP G+   TC   V  C S PC +GGTC   T   Y C C
Sbjct: 326 SRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTC-SDTVAGYICRC 384

Query: 236 KPEFTGLTC 244
              + G  C
Sbjct: 385 PETWGGRDC 393



 Score =  149 bits (375), Expect = 5e-36
 Identities = 88/252 (34%), Positives = 112/252 (44%), Gaps = 41/252 (16%)

Query: 22  YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGL----CGEPGQ 73
           +GA C P      GF      C C PG+QGP C    D+C + P C HG       +  +
Sbjct: 78  HGALCVPQGPDPTGFR-----CYCVPGFQGPRCELDIDECASRP-CHHGATCRNLADRYE 131

Query: 74  CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
           C C  G+ G  C+ +V  C+SAPC + G+C+    G + C CAPGY G  CQ     C  
Sbjct: 132 CHCPLGYAGVTCEMEVDECASAPCLHGGSCLD-GVGSFRCVCAPGYGGTRCQLDLDEC-- 188

Query: 134 NGSPCQHGGTCVDDEGRASHASCLCP-PGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
              PC HGGTC D     +   C C   G+ G  CE     C   PCE++  C +  G F
Sbjct: 189 QSQPCAHGGTCHD---LVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF 245

Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ--------------------VSYE 232
           RC C  G+  + C      CASSPCQ+GG CLQ +                       + 
Sbjct: 246 RCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFL 305

Query: 233 CLCKPEFTGLTC 244
           C C P F G  C
Sbjct: 306 CHCPPGFEGADC 317



 Score =  123 bits (308), Expect = 3e-28
 Identities = 89/286 (31%), Positives = 123/286 (43%), Gaps = 51/286 (17%)

Query: 25  ECFPACNPQNGFCED-DNVCRCQ---PGWQGPLCD----QCVTSP-----GCLHGLCGEP 71
           EC        G C D  N  RC     G++G  C+    +C ++P      CL GL    
Sbjct: 187 ECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF- 245

Query: 72  GQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDD-GLYE------------------ 112
            +C+C  G+ GELC+ D   C+S+PC + G C+   D  LY                   
Sbjct: 246 -RCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGF 304

Query: 113 -CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
            C C PG+ G DC  +   C     PC +GG C D     +   C CP G++G  CE   
Sbjct: 305 LCHCPPGFEGADCGVEVDECA--SRPCLNGGHCQD---LPNGFQCHCPDGYAGPTCEEDV 359

Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL---QHTQ 228
           + C  +PC + G C+D    + CRCP  +  + CS  +T C    C    TC+   +   
Sbjct: 360 DECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGV 419

Query: 229 VSYECLCKPEFTGLTCVKK-----RALSPQQVTRLPSG--YGLAYR 267
            SY C C P   G  C +       A SP Q + +P+G   GLA R
Sbjct: 420 HSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQAS-VPAGGPLGLALR 464



 Score =  110 bits (274), Expect = 3e-24
 Identities = 53/157 (33%), Positives = 70/157 (44%), Gaps = 19/157 (12%)

Query: 91  ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING---SPCQHGGTCVDD 147
           AC+S PCA    C + + G Y C               GP    G    PC HG  CV  
Sbjct: 41  ACASDPCAPGTECQATESGGYTC---------------GPMEPRGCATQPCHHGALCVPQ 85

Query: 148 EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
               +   C C PGF G  CE+  + C   PC +   C ++   + C CP G+   TC  
Sbjct: 86  GPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEM 145

Query: 208 PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            V  CAS+PC +GG+CL     S+ C+C P + G  C
Sbjct: 146 EVDECASAPCLHGGSCLDGVG-SFRCVCAPGYGGTRC 181



 Score =  107 bits (268), Expect = 1e-23
 Identities = 57/176 (32%), Positives = 76/176 (43%), Gaps = 10/176 (5%)

Query: 63  CLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSL--DDGLYECSCAPGYS 120
           C    C    +C  T+         + R C++ PC +   CV    D   + C C PG+ 
Sbjct: 42  CASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQ 101

Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180
           G  C+     C     PC HG TC      A    C CP G++G  CE+  + C   PC 
Sbjct: 102 GPRCELDIDECA--SRPCHHGATC---RNLADRYECHCPLGYAGVTCEMEVDECASAPCL 156

Query: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVS-YECLC 235
           + G C D  G FRC C  G+    C   +  C S PC +GGTC  H  V+ + C C
Sbjct: 157 HGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTC--HDLVNGFRCDC 210



 Score =  104 bits (259), Expect = 2e-22
 Identities = 58/156 (37%), Positives = 73/156 (46%), Gaps = 14/156 (8%)

Query: 57   CVTSPGCLH-GLCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE 112
            C  SP CLH G C +      C C  GW+G  C+  V  C SAPCA  G C +  DG +E
Sbjct: 1060 CAPSP-CLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFE 1117

Query: 113  CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD---EGRASHASCLCPPGFSGNFCEI 169
            C C PG+ G  C+       +    C    TC+D    EG +  A+C C  G +G  C++
Sbjct: 1118 CRCPPGFGGPRCRLP-----VPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQV 1172

Query: 170  VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
                C  NPC N G C   GG   C C A F  + C
Sbjct: 1173 PTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208



 Score =  100 bits (250), Expect = 2e-21
 Identities = 56/167 (33%), Positives = 76/167 (45%), Gaps = 10/167 (5%)

Query: 87   RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD 146
            R    C+ +PC ++G C  L D  + C+C PG+ G  C+    PC  + +PC  G     
Sbjct: 1055 RGAPVCAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHVDPC--HSAPCARGRCHTH 1111

Query: 147  DEGRASHASCLCPPGFSGNFCEIVANS--CTPN-PCENDGVCTDIGGDFRCRCPAGFIDK 203
             +GR     C CPPGF G  C +   S  C+ N  C +   C        C C  G   +
Sbjct: 1112 PDGRFE---CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168

Query: 204  TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRAL 250
             C  P   C ++PC NGGTC     VS EC+C   F+G  C   + L
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVS-ECICNARFSGQFCEVAKGL 1214



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 61/178 (34%), Positives = 74/178 (41%), Gaps = 33/178 (18%)

Query: 23   GAECFPACNPQ----NGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEP 71
            G    P C P     +G C D      C C PGW+GP C    D C ++P C  G C   
Sbjct: 1053 GCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP-CARGRCHTH 1111

Query: 72   G----QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE-------CSCAPGYS 120
                 +C C  G+ G  C   V    S  C+ N TC  LD    E       CSC  G +
Sbjct: 1112 PDGRFECRCPPGFGGPRCRLPV---PSKECSLNVTC--LDGSPCEGGSPAANCSCLEGLA 1166

Query: 121  GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP 178
            G+ CQ    PC  N  PC +GGTC         + C+C   FSG FCE+      P P
Sbjct: 1167 GQRCQVPTLPCEAN--PCLNGGTC---RAAGGVSECICNARFSGQFCEVAKGLPLPLP 1219



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 2/66 (3%)

Query: 174 CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC 233
           C+P+PC N G C     DF C CPA F   TC++ +  C   PC    TC +     + C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW-CPGQPCLPPATC-EEVPDGFVC 868

Query: 234 LCKPEF 239
           + +  F
Sbjct: 869 VAEATF 874



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 13/93 (13%)

Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
           P P +N    +++GG       AG + +        C+  PC NGGTCL  T   + C C
Sbjct: 781 PLPLDNSSQPSELGGRQSWNLTAGCVSEDM------CSPDPCFNGGTCLV-TWNDFHCTC 833

Query: 236 KPEFTGLTCVK------KRALSPQQVTRLPSGY 262
              FTG TC +      +  L P     +P G+
Sbjct: 834 PANFTGPTCAQQLWCPGQPCLPPATCEEVPDGF 866



 Score = 36.2 bits (82), Expect = 0.051
 Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 6/54 (11%)

Query: 92  CSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
           CS  PC N GTC V+ +D  + C+C   ++G  C ++       G PC    TC
Sbjct: 811 CSPDPCFNGGTCLVTWND--FHCTCPANFTGPTCAQQ---LWCPGQPCLPPATC 859



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 4/64 (6%)

Query: 137 PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
           PC +GGTC+      +   C CP  F+G  C      C   PC     C ++   F C  
Sbjct: 815 PCFNGGTCL---VTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFVCVA 870

Query: 197 PAGF 200
            A F
Sbjct: 871 EATF 874



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 13/33 (39%), Positives = 16/33 (48%)

Query: 174 CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
           C P PC + G C D+   FRC C       TC+
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 14/40 (35%), Positives = 20/40 (50%), Gaps = 2/40 (5%)

Query: 85  CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC 124
           C+R  + C   PC + G+CV L    + C CA  + G  C
Sbjct: 603 CERREQ-CRPLPCVHGGSCVDLWTH-FRCDCARPHRGPTC 640


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  154 bits (388), Expect = 2e-37
 Identities = 88/265 (33%), Positives = 123/265 (46%), Gaps = 23/265 (8%)

Query: 25   ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PGQ--C 74
            ECF      +G C+      VC C  G+ G  C    D+C   P   +G+C +  G+  C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255

Query: 75   ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCV 132
             C  G+ G+ C+ ++  CSS+PC N G CV   DG+  Y C+C  G+ G  C+ +   C 
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICV---DGVAGYRCTCVKGFVGLHCETEVNECQ 1312

Query: 133  INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
             N  PC +   C D  G      C CPPGF G  C    + C   PC+N   C D    F
Sbjct: 1313 SN--PCLNNAVCEDQVGGFL---CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367

Query: 193  RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSP 252
            RC C AGF    C   +  C S+PC+N  TC+     SY C C+P F+G  C  +++   
Sbjct: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN-SYSCKCQPGFSGKRCETEQSTGF 1426

Query: 253  QQVTRLPS--GYGLAYRLTPGVHEL 275
                 +    GY +   + P +H L
Sbjct: 1427 NLDFEVSGIYGYVMLDGMLPSLHAL 1451



 Score =  120 bits (302), Expect = 2e-27
 Identities = 71/198 (35%), Positives = 85/198 (42%), Gaps = 41/198 (20%)

Query: 83   ELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK-----KDGPCVING-- 135
            E+  +    C   PC N+GTC  L  G Y C C  GY+G  C+         PC+ NG  
Sbjct: 1188 EISSQVFHECFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVC 1246

Query: 136  -----------------------------SPCQHGGTCVDDEGRASHASCLCPPGFSGNF 166
                                         SPC + G CVD  G A +  C C  GF G  
Sbjct: 1247 KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVD--GVAGY-RCTCVKGFVGLH 1303

Query: 167  CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
            CE   N C  NPC N+ VC D  G F C+CP GF+   C + V  C S PC+NG TC   
Sbjct: 1304 CETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG 1363

Query: 227  TQVSYECLCKPEFTGLTC 244
               S+ CLC   FTG  C
Sbjct: 1364 AN-SFRCLCAAGFTGSHC 1380



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 39/102 (38%), Positives = 49/102 (48%), Gaps = 10/102 (9%)

Query: 27   FPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCICTDGWDGELC 85
            FP  N   G C+  N C C  GW G LC++ +    CL+ G C  P QC C  GW G  C
Sbjct: 3474 FPCQN--GGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC 3531

Query: 86   DRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
               V  C S PC N G CV  +     C C   ++G +C +K
Sbjct: 3532 HTAV--CQS-PCLNGGKCVRPN----RCHCLSSWTGHNCSRK 3566



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 40/128 (31%), Positives = 55/128 (42%), Gaps = 19/128 (14%)

Query: 41   NVCRCQPGWQGP-LCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCAN 99
            +VC     W  P +C      P    G+C  P  C C +GW G LC+  +      PC N
Sbjct: 3454 SVCLENGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPI---CILPCLN 3510

Query: 100  NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP 159
             G CV+     Y+C C PG++G  C        +  SPC +GG CV          C C 
Sbjct: 3511 GGRCVA----PYQCDCPPGWTGSRCH-----TAVCQSPCLNGGKCVRPN------RCHCL 3555

Query: 160  PGFSGNFC 167
              ++G+ C
Sbjct: 3556 SSWTGHNC 3563



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 38/112 (33%), Positives = 49/112 (43%), Gaps = 19/112 (16%)

Query: 137  PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
            PCQ+GG C          +C CP G+ G  CE         PC N G C      ++C C
Sbjct: 3475 PCQNGGICQRPN------ACSCPEGWMGRLCE---EPICILPCLNGGRCV---APYQCDC 3522

Query: 197  PAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
            P G+    C   V     SPC NGG C++  +    C C   +TG  C +KR
Sbjct: 3523 PPGWTGSRCHTAV---CQSPCLNGGKCVRPNR----CHCLSSWTGHNCSRKR 3567



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 10/75 (13%)

Query: 178  PCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKP 237
            PC+N G+C        C CP G++ + C  P+      PC NGG C+      Y+C C P
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI---CILPCLNGGRCV----APYQCDCPP 3524

Query: 238  EFTGLTCVKKRALSP 252
             +TG  C      SP
Sbjct: 3525 GWTGSRCHTAVCQSP 3539



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 22/57 (38%), Positives = 24/57 (42%), Gaps = 1/57 (1%)

Query: 35   GFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG-LCGEPGQCICTDGWDGELCDRDVR 90
            G C     C C PGW G  C   V    CL+G  C  P +C C   W G  C R  R
Sbjct: 3512 GRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSRKRR 3568



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 53/222 (23%), Positives = 71/222 (31%), Gaps = 44/222 (19%)

Query: 84  LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
           LCD     C        GT      G +EC C  GY GK  Q                  
Sbjct: 280 LCDEGKDCCDRMGSCKCGT----HTGHFECICEKGYYGKGLQY----------------- 318

Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
               E  A  +    P G  G       +SC P P EN            C C  G+   
Sbjct: 319 ----ECTACPSGTYKPEGSPGGI-----SSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369

Query: 204 TCSRPVTNC-ASSPCQNG----GTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRL 258
             +  + +C A  P +NG     TC  H   +    C P F          +    +  L
Sbjct: 370 GQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFD--------LVGSSIILCL 421

Query: 259 PSGYGLAYRLTPGVHELP-VQQPEHRILKVSMKELNKKTPLL 299
           P+G          V   P ++QP+H  +  S +E+  KT  L
Sbjct: 422 PNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCL 463



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 44/173 (25%), Positives = 65/173 (37%), Gaps = 41/173 (23%)

Query: 32  PQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQCICTDGWDGELCDR 87
           P   F +DD V  C       LCD+    C     C  G      +CIC  G+ G+    
Sbjct: 265 PSGSFIQDDMV-HCSY-----LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQY 318

Query: 88  DVRACSSAPCANNG------TCVSLDDGLY----------ECSCAPGY--SGKDCQKKDG 129
           +  AC S      G      +C+   D  +          +C C  GY  SG+ C+    
Sbjct: 319 ECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378

Query: 130 PCVINGSPCQHGGTCVDDEGRASHASC--LCPPGFSGNFCEIVANS---CTPN 177
           P +    P ++G    +      +A+C   C PGF     ++V +S   C PN
Sbjct: 379 PAL---KPPENGYFIQNTCNNHFNAACGVRCHPGF-----DLVGSSIILCLPN 423



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 8/68 (11%)

Query: 76   CTDG--WDGELCD-RDVRACS-SAPCANNGTCVSLDDGLYECSCAPGYS--GKDCQKKDG 129
            CTD   W+G      DV  C+  + C+ + +C+++D G Y CSC P Y+  GK+C +   
Sbjct: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVD-GSYICSCVPPYTGDGKNCAEPI- 1787

Query: 130  PCVINGSP 137
             C   G+P
Sbjct: 1788 KCKAPGNP 1795


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  150 bits (378), Expect = 2e-36
 Identities = 79/267 (29%), Positives = 115/267 (43%), Gaps = 48/267 (17%)

Query: 25   ECFPACNPQNGFCEDDNV---CRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQC 74
            +C       N  C+D ++   C C   W+G  C+Q    C  +P   +  C +     +C
Sbjct: 736  DCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRC 795

Query: 75   ICTDGWDGELCDRDVRACSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
             CT GW G+ C  ++  C S PC N G C  S   G + C C P Y+G+ C ++   C +
Sbjct: 796  ECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDL 855

Query: 134  NGSPCQHGGTCV------------------------------------DDEGRASHASCL 157
              +PC++  TC+                                    D E   ++  C+
Sbjct: 856  LHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCI 915

Query: 158  CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
            C PGFSG+ CEI  N C+  PC+N+G C D+   F C C   +    C   V  C  SPC
Sbjct: 916  CRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPC 975

Query: 218  QNGGTCLQHTQVSYECLCKPEFTGLTC 244
             +   C+  T   Y CLC P +TG+ C
Sbjct: 976  LDEENCVYRTD-GYNCLCAPGYTGINC 1001



 Score =  147 bits (372), Expect = 1e-35
 Identities = 79/222 (35%), Positives = 109/222 (49%), Gaps = 18/222 (8%)

Query: 35   GFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ---CICTDGWDGEL 84
            G CED   +  C C+PG+ G LC+    +C + P   +G C +      C C   + G  
Sbjct: 903  GDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPF 962

Query: 85   CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
            C+ DV  C  +PC +   CV   DG Y C CAPGY+G +C+     C+    PC H G C
Sbjct: 963  CELDVNKCKISPCLDEENCVYRTDG-YNCLCAPGYTGINCEINLDECL--SEPCLHDGVC 1019

Query: 145  VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
            +D     +H +C C  GF G  CE  AN C  NPC + G CT++  ++ C C A      
Sbjct: 1020 IDG---INHYTCDCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQ 1075

Query: 205  CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
            C   + +C S PC N G C Q +   + C+C   +TG  C K
Sbjct: 1076 CKIKINDCTSIPCMNEGFC-QKSAHGFTCICPRGYTGAYCEK 1116



 Score =  140 bits (354), Expect = 1e-33
 Identities = 68/186 (36%), Positives = 94/186 (50%), Gaps = 25/186 (13%)

Query: 76  CTDGWDGELCDRDVRACSSAPCANNGTCVS--------------LDDGLYECSCAPGYSG 121
           C  G+ G  C+ D+  C+S PC N  TC+               + DG + C C PGY G
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDG-FSCLCNPGYVG 727

Query: 122 KDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIVANSCTPNPC 179
             C++    C++N   C+H  TC D      H S  C+C   + GNFCE  +N C  NPC
Sbjct: 728 IRCEQDIDDCILNA--CEHNSTCKD-----LHLSYQCVCLSDWEGNFCEQESNECKMNPC 780

Query: 180 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT-QVSYECLCKPE 238
           +N+  CTD+   +RC C +G+  + CS  +  C S PC NGG C + T    + CLC P 
Sbjct: 781 KNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPL 840

Query: 239 FTGLTC 244
           +TG  C
Sbjct: 841 YTGQFC 846



 Score =  140 bits (354), Expect = 1e-33
 Identities = 86/291 (29%), Positives = 118/291 (40%), Gaps = 70/291 (24%)

Query: 23  GAECFPACNPQNGFCE--------DDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG-- 72
           GA C     P N FC+        D   C C PG+ G  C+Q +    C+   C      
Sbjct: 693 GATCID--QPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDD--CILNACEHNSTC 748

Query: 73  -------QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
                  QC+C   W+G  C+++   C   PC NN TC  L    Y C C  G++G++C 
Sbjct: 749 KDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKS-YRCECTSGWTGQNCS 807

Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCEND- 182
           ++   C  +  PC +GG C  +        CLCPP ++G FC    N C    NPC N+ 
Sbjct: 808 EEINEC--DSDPCMNGGLC-HESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNS 864

Query: 183 --------------------------------------GVCTDIGGDFRCRCPAGFIDKT 204
                                                 G C D+  +FRC C  GF    
Sbjct: 865 TCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSL 924

Query: 205 CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC---VKKRALSP 252
           C   +  C+S PC+N GTC+  T   + C C+PE+ G  C   V K  +SP
Sbjct: 925 CEIEINECSSEPCKNNGTCVDLTN-RFFCNCEPEYHGPFCELDVNKCKISP 974



 Score =  135 bits (340), Expect = 6e-32
 Identities = 74/211 (35%), Positives = 101/211 (47%), Gaps = 19/211 (9%)

Query: 43   CRCQPGWQGPLCDQCVTSPGCLHGLCGEPG---------QCICTDGWDGELCDRDVRACS 93
            C C+  ++G  C+  +    CL   C + G         +CIC  G+ G LC+ ++  CS
Sbjct: 876  CICREEFEGKNCE--IDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECS 933

Query: 94   SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH 153
            S PC NNGTCV L +  + C+C P Y G  C+     C I  SPC     CV    R   
Sbjct: 934  SEPCKNNGTCVDLTNRFF-CNCEPEYHGPFCELDVNKCKI--SPCLDEENCVY---RTDG 987

Query: 154  ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
             +CLC PG++G  CEI  + C   PC +DGVC D    + C C +GF    C     +C 
Sbjct: 988  YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCL 1047

Query: 214  SSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            S+PC + G C +     Y C C  + T   C
Sbjct: 1048 SNPCLH-GRCTELIN-EYPCSCDADGTSTQC 1076



 Score =  121 bits (303), Expect = 1e-27
 Identities = 77/233 (33%), Positives = 104/233 (44%), Gaps = 22/233 (9%)

Query: 25   ECFPACNPQNGFCEDD---NVCRCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQC 74
            EC       +G C D      C C+ G+ G  C+     C+++P CLHG C E      C
Sbjct: 1007 ECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNP-CLHGRCTELINEYPC 1065

Query: 75   ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV-- 132
             C        C   +  C+S PC N G C     G + C C  GY+G  C+K    C   
Sbjct: 1066 SCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG-FTCICPRGYTGAYCEKSIDNCAEP 1124

Query: 133  -INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
             +N   C +GG CVD  G      C C PGFSG FCEI  N C+ +PC +   C D    
Sbjct: 1125 ELNSVICLNGGICVDGPGHTF--DCRCLPGFSGQFCEININECSSSPCLHGADCEDHING 1182

Query: 192  FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            + C+C  G+    C   +  C  + C +   C+++   S  CLC P F  +TC
Sbjct: 1183 YVCKCQPGWSGHHCENEL-ECIPNSCVH-ELCMENEPGS-TCLCTPGF--MTC 1230



 Score =  105 bits (261), Expect = 9e-23
 Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 17/201 (8%)

Query: 54  CDQCVTSPGCL-HGLC-----GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCV--- 104
           C + ++S  C  HG C      +   C C   + G+ C +++ ACS  PC NNG+C+   
Sbjct: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKR 232

Query: 105 -SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS 163
            + D+  YEC C P ++GK+C +  G C      C HG         ++   C C   FS
Sbjct: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCFHGNC---SNITSNSFICECDEQFS 287

Query: 164 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
           G FCE+ A  C        G+C +    +   CP G   +     V+  +  PCQNG  C
Sbjct: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC 347

Query: 224 LQHTQVSYECLCKPEFTGLTC 244
           ++ +     C+C P FT L C
Sbjct: 348 IKISN-DVMCICSPIFTDLLC 367



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 60/251 (23%), Positives = 93/251 (37%), Gaps = 54/251 (21%)

Query: 43  CRCQPGWQGPLC---DQCVTSPGCLHGLC--------GEPGQCICTDGWDGELCDRDVRA 91
           C CQP + G  C   D C   P   +G C         +  +C+C   + G+ C   +  
Sbjct: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259

Query: 92  CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI------------------ 133
           C    C + G C ++    + C C   +SG  C+    PCV                   
Sbjct: 260 CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318

Query: 134 ---------NGS---------PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT 175
                    NG          PCQ+G  C+     ++   C+C P F+   C+ +  SC 
Sbjct: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI---SNDVMCICSPIFTDLLCKSIQTSCE 375

Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC--ASSPCQNGGTCLQHTQVSYEC 233
             P  N+  C     D+ C C +GF +K C + + +C   S  C N   C  +    ++ 
Sbjct: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF-NIIGRFKY 434

Query: 234 LCKPEFTGLTC 244
           +C P  T   C
Sbjct: 435 VCIPGCTKNPC 445



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 50/201 (24%), Positives = 74/201 (36%), Gaps = 18/201 (8%)

Query: 57  CVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA 116
           C     CL     +  + +C   W G +   +        C +   C   +     CSC+
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKD-EINRPRCSCS 593

Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
             Y G+ C      C+ N S   HG  C+     + + +C     +  N CEI    C  
Sbjct: 594 LSYIGRLCVVNVDYCLGNHSISVHG-LCL---ALSHNCNCSGLQRYERNICEIDTEDCKS 649

Query: 177 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH---------- 226
             C+N    T + G F  +C  GF    C   +  CAS PC+NG TC+            
Sbjct: 650 ASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVP 709

Query: 227 ---TQVSYECLCKPEFTGLTC 244
                  + CLC P + G+ C
Sbjct: 710 PFKVVDGFSCLCNPGYVGIRC 730



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 7/85 (8%)

Query: 92   CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRA 151
            C+   C NNGTC+S ++ L+ C C   YSGK CQ          +PC +G TCV   G  
Sbjct: 2339 CAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFAS----CENNPCGNGATCVPKSG-- 2391

Query: 152  SHASCLCPPGFSGNFCEIVANSCTP 176
            +   CLCP G SG  C    N   P
Sbjct: 2392 TDIVCLCPYGRSGPLCTDAINITQP 2416



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 1/79 (1%)

Query: 173  SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
            +C  N C N G CT  G  F CRC   +   TC++ V +C ++ C +   C+     SY 
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYS 2936

Query: 233  CLCKPEFTGLTCVKKRALS 251
            CLC   + G  C  K + S
Sbjct: 2937 CLCTLGWVGRYCENKTSFS 2955



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 9/95 (9%)

Query: 92   CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP---CQHGGTCVDDE 148
            CS   C N GTC+     +Y C+C  G+ G  C +    C     P   C  G TC+   
Sbjct: 2614 CSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS-- 2670

Query: 149  GRASHA-SCLCPPGFSGNFCEIVANSCTPNPCEND 182
                H  +C CP G +G +CE   +   P+   N+
Sbjct: 2671 --LPHGYTCFCPLGTTGIYCEQALSISDPSFRSNE 2703



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)

Query: 174  CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC 233
            C  + C N+G C     +  C CP  +  K C     +C ++PC NG TC+  +     C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396

Query: 234  LCKPEFTGLTC 244
            LC    +G  C
Sbjct: 2397 LCPYGRSGPLC 2407



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 6/70 (8%)

Query: 138  CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRC 196
            C++ GTC+ D     +  C CP  +SG  C+    SC  NPC N   C    G D  C C
Sbjct: 2344 CRNNGTCISDN---ENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLC 2398

Query: 197  PAGFIDKTCS 206
            P G     C+
Sbjct: 2399 PYGRSGPLCT 2408



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 6/83 (7%)

Query: 86   DRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
            D D  AC    C N G C +++   + C C P ++G  C +    C+ N   C H   C+
Sbjct: 2873 DCDGTACGYNTCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSVS-CLNN--LCLHQSLCI 2928

Query: 146  DDEGRASHASCLCPPGFSGNFCE 168
             D+  +   SCLC  G+ G +CE
Sbjct: 2929 PDQSFSY--SCLCTLGWVGRYCE 2949



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 16/85 (18%)

Query: 56   QCVTSPGCLHGLCGEPGQCI---------CTDGWDGELCDRDVRACSSA-----PCANNG 101
            QC  SP C    CG  G CI         CT GW G  C   V  C         C+   
Sbjct: 2608 QCHASP-CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666

Query: 102  TCVSLDDGLYECSCAPGYSGKDCQK 126
            TC+SL  G Y C C  G +G  C++
Sbjct: 2667 TCISLPHG-YTCFCPLGTTGIYCEQ 2690



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 6/86 (6%)

Query: 171  ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC-----ASSPCQNGGTCLQ 225
            A+ C+   C N G C + G    C C  G+    C+  V+ C         C  G TC+ 
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670

Query: 226  HTQVSYECLCKPEFTGLTCVKKRALS 251
                 Y C C    TG+ C +  ++S
Sbjct: 2671 LPH-GYTCFCPLGTTGIYCEQALSIS 2695



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 10/86 (11%)

Query: 130  PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC-----TPNPCENDGV 184
            PC +    C +GGTC++     +   C C  G+ G+FC    ++C      P+ C     
Sbjct: 2613 PCSL--MKCGNGGTCIES---GTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667

Query: 185  CTDIGGDFRCRCPAGFIDKTCSRPVT 210
            C  +   + C CP G     C + ++
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQALS 2693



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 25/73 (34%), Positives = 29/73 (39%), Gaps = 11/73 (15%)

Query: 61   PGCLHGLCGEPGQCI---------CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLY 111
            P C H LC   G CI         C   + G+LC     +C + PC N  TCV       
Sbjct: 2337 PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDI 2394

Query: 112  ECSCAPGYSGKDC 124
             C C  G SG  C
Sbjct: 2395 VCLCPYGRSGPLC 2407



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 21/51 (41%), Positives = 25/51 (49%), Gaps = 7/51 (13%)

Query: 43   CRCQPGWQGPLCDQCVTSPG--CLHGLCGEPGQ-----CICTDGWDGELCD 86
            CRC P W G  C+Q V+     CLH     P Q     C+CT GW G  C+
Sbjct: 2899 CRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 17/59 (28%), Positives = 26/59 (44%), Gaps = 1/59 (1%)

Query: 69   GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
            G    C C   W G  C++ V +C +  C +   C+      Y C C  G+ G+ C+ K
Sbjct: 2894 GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK 2951



 Score = 35.4 bits (80), Expect = 0.087
 Identities = 18/43 (41%), Positives = 20/43 (46%), Gaps = 4/43 (9%)

Query: 212  CASSPCQNGGTC----LQHTQVSYECLCKPEFTGLTCVKKRAL 250
            C    C NGGTC    L    VS++C C   FTG  C K   L
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGL 2145



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 13/35 (37%), Positives = 20/35 (57%), Gaps = 1/35 (2%)

Query: 210  TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            T C  + C+NGG C  +   ++ C C P++ G TC
Sbjct: 2877 TACGYNTCRNGGECTVN-GTTFSCRCLPDWAGNTC 2910



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)

Query: 92   CSSAPCANNGTC--VSLDDGL--YECSCAPGYSGKDCQKKDG 129
            C    C N GTC  + L  G+  ++C C   ++G+ C+K  G
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG 2144



 Score = 29.6 bits (65), Expect = 4.8
 Identities = 17/42 (40%), Positives = 19/42 (45%), Gaps = 4/42 (9%)

Query: 130  PCVINGSPCQHGGTCVD---DEGRASHASCLCPPGFSGNFCE 168
            P V     C +GGTC       G  S   C CP  F+G FCE
Sbjct: 2100 PSVCQQDVCHNGGTCHAIFLSSGIVSF-QCDCPLHFTGRFCE 2140


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  150 bits (378), Expect = 2e-36
 Identities = 91/244 (37%), Positives = 115/244 (47%), Gaps = 39/244 (15%)

Query: 43  CRCQPGWQGPLC----DQCVTSPGCLHG-LC--GEPG-QCICT-DGWDGELCDRDVRACS 93
           C C PG+ G  C    D+C + P CLHG LC  GE    C CT  G+ G  C+  +  C 
Sbjct: 248 CDCAPGFLGDHCELNTDECASQP-CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCW 306

Query: 94  SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD-----DE 148
           S PC NN TC    D  Y C C PGY+G  C+     C  N +PCQ  G CV+       
Sbjct: 307 SKPCHNNATCEDSVDN-YTCHCWPGYTGAQCEIDLNEC--NSNPCQSNGECVELSSEKQY 363

Query: 149 GR------------ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
           GR            AS   C+C PGF+G  CE   N C+ NPC+N G C ++ G++ C C
Sbjct: 364 GRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423

Query: 197 PAGFIDKT------CSRPVTNCASSPCQNGGTCLQH---TQVSYECLCKPEFTGLTCVKK 247
           P   + +T      CS  +  C    C N GTC+ H    Q  + CLC   +TG  C   
Sbjct: 424 PFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA 483

Query: 248 RALS 251
             LS
Sbjct: 484 TTLS 487



 Score =  149 bits (375), Expect = 5e-36
 Identities = 76/211 (36%), Positives = 105/211 (49%), Gaps = 15/211 (7%)

Query: 42  VCRCQPGWQGPLCDQCVTSPG---CLHG-LCGEPG---QCICTDGWDGELCDRDVRACSS 94
           +C+C PG+ G +C+  + S G   C HG +C +      CIC  G+ G  C+ D   C+S
Sbjct: 95  LCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECAS 154

Query: 95  APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
           +PC N   C    DG Y C C PGY G+ C  +   C     PC++  TC+++ GR +  
Sbjct: 155 SPCQNGAVCQDGIDG-YSCFCVPGYQGRHCDLEVDECA--SDPCKNEATCLNEIGRYT-- 209

Query: 155 SCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCAS 214
            C+CP  +SG  CE+  + C   PC N   C D  G + C C  GF+   C      CAS
Sbjct: 210 -CICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECAS 268

Query: 215 SPCQNGGTCLQHTQVSYECLCKPE-FTGLTC 244
            PC +GG C+   +  Y C C    FTG  C
Sbjct: 269 QPCLHGGLCVD-GENRYSCNCTGSGFTGTHC 298



 Score =  135 bits (340), Expect = 6e-32
 Identities = 74/215 (34%), Positives = 102/215 (47%), Gaps = 19/215 (8%)

Query: 33  QNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDG--ELCDRDVR 90
           +N FC  +N  RC       L + C  +  C      +   C C+D  +   + CD    
Sbjct: 23  KNSFCNKNNT-RC-------LSNSCQNNSTCKD--FSKDNDCSCSDTANNLDKDCDNMKD 72

Query: 91  ACSSAPCANNGTCVSLD-DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEG 149
            C S PC  + TCV+   +  + C C PGYSG  C+   G C  N   CQHGG C  D  
Sbjct: 73  PCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNS--CQHGGICHQDP- 129

Query: 150 RASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV 209
              +  C+CP G++G FCEI  + C  +PC+N  VC D    + C C  G+  + C   V
Sbjct: 130 --IYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187

Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             CAS PC+N  TCL      Y C+C   ++G+ C
Sbjct: 188 DECASDPCKNEATCLNEIG-RYTCICPHNYSGVNC 221



 Score =  127 bits (318), Expect = 2e-29
 Identities = 72/234 (30%), Positives = 100/234 (42%), Gaps = 23/234 (9%)

Query: 26  CFPACNPQNGFCED---DNVCRCQPGWQG------PLCDQCVTSPGCLHGLC-GEPGQ-- 73
           C       N  C+D   DN C C             + D C ++P      C   PG+  
Sbjct: 34  CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93

Query: 74  --CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE-CSCAPGYSGKDCQKKDGP 130
             C C  G+ G +C+  + +C    C + G C    D +Y  C C  GY+G+ C+     
Sbjct: 94  FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQ--DPIYPVCICPAGYAGRFCEIDHDE 151

Query: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
           C    SPCQ+G  C D        SC C PG+ G  C++  + C  +PC+N+  C +  G
Sbjct: 152 CA--SSPCQNGAVCQDG---IDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206

Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            + C CP  +    C   +  C S PC NG TC Q    +Y C C P F G  C
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCLNGATC-QDALGAYFCDCAPGFLGDHC 259



 Score =  127 bits (318), Expect = 2e-29
 Identities = 64/186 (34%), Positives = 93/186 (50%), Gaps = 20/186 (10%)

Query: 35   GFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGEL 84
            G CED      C C  GW G  C    D+C ++P C+HG C +      C C  G+ G  
Sbjct: 1152 GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCTCEPGYTGVN 1210

Query: 85   CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP-----CQ 139
            C+ D+  C S  CAN  TC+S  +G Y C C   ++GK C++   P  + G+      C 
Sbjct: 1211 CEVDIDNCQSHQCANGATCISHTNG-YSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCY 1269

Query: 140  HGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAG 199
            +GG C + +   +   C+C PGF+G +CE   + C  +PC N G+C D+   F+C C   
Sbjct: 1270 NGGNCTEFQ---TELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVA 1326

Query: 200  FIDKTC 205
            F  + C
Sbjct: 1327 FAGERC 1332



 Score =  123 bits (309), Expect = 2e-28
 Identities = 70/215 (32%), Positives = 94/215 (43%), Gaps = 26/215 (12%)

Query: 37   CEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAP 96
            C   NVC   P   G  C+   +S             C C  GW G+ C+ ++  C S P
Sbjct: 1137 CLQLNVCNSNPCLHGGNCEDIYSSY-----------HCSCPLGWSGKHCELNIDECFSNP 1185

Query: 97   CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASC 156
            C + G C S     Y C+C PGY+G +C+     C      C +G TC+      +  SC
Sbjct: 1186 CIH-GNC-SDRVAAYHCTCEPGYTGVNCEVDIDNC--QSHQCANGATCIS---HTNGYSC 1238

Query: 157  LCPPGFSGNFCE-------IVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV 209
            LC   F+G FC        +  N  T   C N G CT+   + +C C  GF  + C + +
Sbjct: 1239 LCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI 1298

Query: 210  TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
              CAS PC NGG C Q     ++CLC   F G  C
Sbjct: 1299 DECASDPCVNGGLC-QDLLNKFQCLCDVAFAGERC 1332



 Score =  104 bits (260), Expect = 1e-22
 Identities = 57/165 (34%), Positives = 77/165 (46%), Gaps = 15/165 (9%)

Query: 89   VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
            +  C+S PC + G C  +    Y CSC  G+SGK C+     C  N  PC HG  C D  
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSS-YHCSCPLGWSGKHCELNIDECFSN--PCIHGN-CSD-- 1193

Query: 149  GRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR- 207
             R +   C C PG++G  CE+  ++C  + C N   C      + C C   F  K C + 
Sbjct: 1194 -RVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQS 1252

Query: 208  --PVTNCASSP----CQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
              P T C +      C NGG C +  Q   +C+C+P FTG  C K
Sbjct: 1253 RLPSTVCGNEKTNLTCYNGGNCTEF-QTELKCMCRPGFTGEWCEK 1296



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 48/117 (41%), Positives = 59/117 (50%), Gaps = 5/117 (4%)

Query: 132  VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
            V N +PC HGG C D     S   C CP G+SG  CE+  + C  NPC + G C+D    
Sbjct: 1142 VCNSNPCLHGGNCEDIY---SSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAA 1197

Query: 192  FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
            + C C  G+    C   + NC S  C NG TC+ HT   Y CLC   FTG  C + R
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTN-GYSCLCFGNFTGKFCRQSR 1253



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 59/173 (34%), Positives = 74/173 (42%), Gaps = 40/173 (23%)

Query: 34  NGFCED--DN-VCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ------------- 73
           N  CED  DN  C C PG+ G  C+    +C ++P   +G C E                
Sbjct: 313 NATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSS 372

Query: 74  ----------CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC------AP 117
                     CIC  G+ G  C+ DV  CSS PC N GTC +L  G Y C C        
Sbjct: 373 FSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENL-PGNYTCHCPFDNLSRT 431

Query: 118 GYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEI 169
            Y G+DC      C      C + GTC+       H  SCLCP G++G+ CEI
Sbjct: 432 FYGGRDCSDILLGC--THQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 30/70 (42%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
           NSC  NPC N GVC     DF C CPA    K C   V  C  SPC +G  C Q     +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQC-QPVLQGF 946

Query: 232 ECLCKPEFTG 241
           EC+    F G
Sbjct: 947 ECIANAVFNG 956



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 4/54 (7%)

Query: 91  ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
           +C S PC N G C S  D  + CSC    SGK C++         SPC HG  C
Sbjct: 890 SCKSNPCHNGGVCHSRWDD-FSCSCPALTSGKACEEVQW---CGFSPCPHGAQC 939



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 26/73 (35%), Positives = 30/73 (41%), Gaps = 6/73 (8%)

Query: 128 DGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
           D  C  N  PC +GG C     R    SC CP   SG  CE V   C  +PC +   C  
Sbjct: 888 DNSCKSN--PCHNGGVC---HSRWDDFSCSCPALTSGKACEEV-QWCGFSPCPHGAQCQP 941

Query: 188 IGGDFRCRCPAGF 200
           +   F C   A F
Sbjct: 942 VLQGFECIANAVF 954



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 7/54 (12%)

Query: 43   CRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDV 89
            C C+PG+ G  C    D+C + P    GLC +     QC+C   + GE C+ D+
Sbjct: 1283 CMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDL 1336



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 13/36 (36%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
           C S PCQ+ G C+ +  +SY+C C   + G  C+++
Sbjct: 676 CESQPCQSRGRCI-NLWLSYQCDCHRPYEGPNCLRE 710



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 1/36 (2%)

Query: 92  CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
           C S PC + G C++L    Y+C C   Y G +C ++
Sbjct: 676 CESQPCQSRGRCINLWLS-YQCDCHRPYEGPNCLRE 710


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  147 bits (371), Expect = 2e-35
 Identities = 79/218 (36%), Positives = 101/218 (46%), Gaps = 26/218 (11%)

Query: 43  CRCQPGWQGPLC---DQCVTSPGCLHG--------LCGEPGQCICTDGWDGELCDRDVRA 91
           C C PG  G LC   D C++ P   HG        L G    C+C  G+ G  C +D+  
Sbjct: 379 CLCPPGRTGLLCHLEDMCLSQP--CHGDAQCSTNPLTGST-LCLCQPGYSGPTCHQDLDE 435

Query: 92  CSSA-----PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD 146
           C  A     PC + G+C++   G + C C PGY+G  C+     C+    PC  G TC+D
Sbjct: 436 CLMAQQGPSPCEHGGSCLNTP-GSFNCLCPPGYTGSRCEADHNECL--SQPCHPGSTCLD 492

Query: 147 DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
                +   CLCPPG  G  CE+  N C   PC N   C D+   F+C C  GF    C 
Sbjct: 493 ---LLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE 549

Query: 207 RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             +  C SSPC NGG C Q    ++ C C P F G  C
Sbjct: 550 EDIDECRSSPCANGGQC-QDQPGAFHCKCLPGFEGPRC 586



 Score =  143 bits (361), Expect = 2e-34
 Identities = 82/233 (35%), Positives = 107/233 (45%), Gaps = 25/233 (10%)

Query: 24  AECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTS----PGCLHG--LCGEPG- 72
           A+C  + NP  G      +C CQPG+ GP C    D+C+ +      C HG      PG 
Sbjct: 405 AQC--STNPLTG----STLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGS 458

Query: 73  -QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC 131
             C+C  G+ G  C+ D   C S PC    TC+ L    + C C PG  G+ C+ +   C
Sbjct: 459 FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDL-LATFHCLCPPGLEGQLCEVETNEC 517

Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
               +PC +   C D     +   C+C PGFSG  CE   + C  +PC N G C D  G 
Sbjct: 518 A--SAPCLNHADCHD---LLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGA 572

Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           F C+C  GF    C   V  C S PC  G +CL     ++ CLC   FTG  C
Sbjct: 573 FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLD-LPGAFFCLCPSGFTGQLC 624



 Score =  140 bits (353), Expect = 2e-33
 Identities = 76/214 (35%), Positives = 106/214 (49%), Gaps = 16/214 (7%)

Query: 43  CRCQPGWQGPLC---DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRAC--SS 94
           C C PGW G  C   D C  +P    G+C       QC C  G++G  C+RDV  C    
Sbjct: 143 CSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDP 202

Query: 95  APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC-VDDEGRASH 153
            PC    +C +   G ++C C  G  G  C+ + GPC   G  C +GGTC +  E  ++ 
Sbjct: 203 GPCPKGTSCHNTL-GSFQCLCPVGQEGPRCELRAGPCPPRG--CSNGGTCQLMPEKDSTF 259

Query: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
             CLCPPGF G  CE+  ++C  + C+N G C D    + C CP  +    CS  V  C 
Sbjct: 260 HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECE 319

Query: 214 SS---PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           +     C+NGGTC Q++  S+ C+C   + G +C
Sbjct: 320 TQGPPHCRNGGTC-QNSAGSFHCVCVSGWGGTSC 352



 Score =  140 bits (352), Expect = 2e-33
 Identities = 77/221 (34%), Positives = 95/221 (42%), Gaps = 26/221 (11%)

Query: 43   CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
            C C  G+ G  C    D C   P   +  C + G    C+C  GW G LC+  + +C  A
Sbjct: 830  CLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKA 889

Query: 96   P----------CANNGTCVSLDDG-LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
                       C N G CV  D G  Y C C PG+ G  CQ    PC     PCQ+G TC
Sbjct: 890  ALSQGIDVSSLCHNGGLCV--DSGPSYFCHCPPGFQGSLCQDHVNPC--ESRPCQNGATC 945

Query: 145  VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
            +    + S   C C PG+ G  C    ++C   PC N G CT   G F C CP GF+   
Sbjct: 946  M---AQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002

Query: 205  CSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
            C   V  C   PC   GT   H+   ++ C C P  TG  C
Sbjct: 1003 CEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWC 1043



 Score =  137 bits (345), Expect = 2e-32
 Identities = 79/240 (32%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 22  YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVT---SPGCLHGLCGEPGQ----C 74
           +G  C+P  +  N        C C  G+ GP C + +T   S  CL+G    P      C
Sbjct: 702 HGGTCYPQPSGYN--------CTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYC 753

Query: 75  ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
            C     G  C      C SAPC N GTCV+   G + C CA G+ G  C+ K  P   +
Sbjct: 754 TCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRP-GTFSCLCAMGFQGPRCEGKLRPSCAD 812

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
            SPC++  TC D         CLCP G++G  C+ + + C   PC  +  C   G  F C
Sbjct: 813 -SPCRNRATCQDS---PQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHC 868

Query: 195 RCPAGFIDKTCSRPVTNC----------ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C  G+    C+ P+++C           SS C NGG C+  +  SY C C P F G  C
Sbjct: 869 LCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVD-SGPSYFCHCPPGFQGSLC 927



 Score =  137 bits (345), Expect = 2e-32
 Identities = 81/237 (34%), Positives = 104/237 (43%), Gaps = 29/237 (12%)

Query: 29  ACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLC-GEPG--QCICTDGWD 81
           +CNP  G       C C P   GP C    D CV++P    G C   PG   C+C  G+ 
Sbjct: 743 SCNPSPG----GYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQ 798

Query: 82  GELCDRDVR-ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
           G  C+  +R +C+ +PC N  TC     G   C C  GY+G  CQ     C     PC  
Sbjct: 799 GPRCEGKLRPSCADSPCRNRATCQDSPQGP-RCLCPTGYTGGSCQTLMDLCA--QKPCPR 855

Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC----------TPNPCENDGVCTDIGG 190
              C+   G + H  CLC  G++G  C +  +SC            + C N G+C D G 
Sbjct: 856 NSHCLQT-GPSFH--CLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP 912

Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
            + C CP GF    C   V  C S PCQNG TC+      Y C C P + G  C K+
Sbjct: 913 SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPS-GYLCQCAPGYDGQNCSKE 968



 Score =  135 bits (341), Expect = 5e-32
 Identities = 75/223 (33%), Positives = 105/223 (47%), Gaps = 29/223 (13%)

Query: 41  NVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRA 91
           ++C C PG+ GP C+         QC     C  GL  +   C+C + W G  C  DV  
Sbjct: 260 HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGL--DTYTCLCPETWTGWDCSEDVDE 317

Query: 92  CSSAP---CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
           C +     C N GTC +   G + C C  G+ G  C++    C+   + C  G TC+D  
Sbjct: 318 CETQGPPHCRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCI--AATCAPGSTCID-- 372

Query: 149 GRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCT--DIGGDFRCRCPAGFIDKTCS 206
            R    SCLCPPG +G  C +  + C   PC  D  C+   + G   C C  G+   TC 
Sbjct: 373 -RVGSFSCLCPPGRTGLLCHL-EDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCH 430

Query: 207 RPVTNC-----ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           + +  C       SPC++GG+CL +T  S+ CLC P +TG  C
Sbjct: 431 QDLDECLMAQQGPSPCEHGGSCL-NTPGSFNCLCPPGYTGSRC 472



 Score =  135 bits (339), Expect = 8e-32
 Identities = 78/268 (29%), Positives = 105/268 (39%), Gaps = 68/268 (25%)

Query: 43  CRCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
           C C PG +G LC+    +C ++P   H  C +     QCIC  G+ G  C+ D+  C S+
Sbjct: 499 CLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSS 558

Query: 96  PCANNGTCVSLDDGLYECSCAPGYSGKDCQKK-----DGPCVINGSP------------- 137
           PCAN G C     G + C C PG+ G  CQ +       PC +  S              
Sbjct: 559 PCANGGQCQD-QPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPS 617

Query: 138 ----------------CQHGGTCVDDEGRAS-------------------------HASC 156
                           CQ    C D + +A+                          +SC
Sbjct: 618 GFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSC 677

Query: 157 LCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
           +C  G++G  CE     C   PC + G C      + C CP G+   TCS  +T C S P
Sbjct: 678 VCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGP 737

Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           C NGG+C   +   Y C C P  TG  C
Sbjct: 738 CLNGGSC-NPSPGGYYCTCPPSHTGPQC 764



 Score =  131 bits (329), Expect = 1e-30
 Identities = 72/218 (33%), Positives = 100/218 (45%), Gaps = 23/218 (10%)

Query: 43  CRCQPGWQGPLCD----QCVTSPG------CLHGLCGEPGQCICTDGWDGELCDRDVRAC 92
           C C PG++G  C+    +C   PG        H   G   QC+C  G +G  C+     C
Sbjct: 180 CHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGS-FQCLCPVGQEGPRCELRAGPC 238

Query: 93  SSAPCANNGTCVSL---DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEG 149
               C+N GTC  +   D   + C C PG+ G DC+     CV +   CQ+GGTC D   
Sbjct: 239 PPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSH--QCQNGGTCQDG-- 294

Query: 150 RASHASCLCPPGFSGNFCEIVANSCT---PNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
                +CLCP  ++G  C    + C    P  C N G C +  G F C C +G+   +C 
Sbjct: 295 -LDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353

Query: 207 RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
             + +C ++ C  G TC+     S+ CLC P  TGL C
Sbjct: 354 ENLDDCIAATCAPGSTCIDRVG-SFSCLCPPGRTGLLC 390



 Score =  131 bits (329), Expect = 1e-30
 Identities = 79/258 (30%), Positives = 112/258 (43%), Gaps = 41/258 (15%)

Query: 25  ECFPACNPQNGFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PGQ--C 74
           EC  +     G C+D      C+C PG++GP C    D+C++ P  +   C + PG   C
Sbjct: 554 ECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFC 613

Query: 75  ICTDGWDGELCD------------------RDVRAC-------SSAPCANNGTCVSLDDG 109
           +C  G+ G+LC+                  +D   C         AP  +N TC      
Sbjct: 614 LCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQ 673

Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
              C C  G++G +C+ + G C+   +PC HGGTC     + S  +C CP G++G  C  
Sbjct: 674 RSSCVCDVGWTGPECEAELGGCI--SAPCAHGGTCYP---QPSGYNCTCPTGYTGPTCSE 728

Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
              +C   PC N G C    G + C CP       C      C S+PC NGGTC+     
Sbjct: 729 EMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPG- 787

Query: 230 SYECLCKPEFTGLTCVKK 247
           ++ CLC   F G  C  K
Sbjct: 788 TFSCLCAMGFQGPRCEGK 805



 Score =  127 bits (318), Expect = 2e-29
 Identities = 85/271 (31%), Positives = 108/271 (39%), Gaps = 39/271 (14%)

Query: 7   LLRVLLLLLAFGHSTYGAEC--FPACNPQNGFCED----DNVCRCQPGWQGPLC---DQC 57
           LL +LLLL        G  C  FP      G C         C+C PG+ G  C   D C
Sbjct: 9   LLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPC 68

Query: 58  VTSPGCLHG------------LCGEPGQ------CICTDGWDGELCDRDVR-ACSSAPCA 98
             +  C +G            L   P        C C  G+ GE C   +   C  + C+
Sbjct: 69  QNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCS 128

Query: 99  NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC 158
             G C     G  +CSC PG++G+ CQ +D     + +PC +GG C+          C C
Sbjct: 129 KRGRCHIQASGRPQCSCMPGWTGEQCQLRD---FCSANPCVNGGVCL---ATYPQIQCHC 182

Query: 159 PPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
           PPGF G+ CE   N C   P PC     C +  G F+C CP G     C      C    
Sbjct: 183 PPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG 242

Query: 217 CQNGGTCL---QHTQVSYECLCKPEFTGLTC 244
           C NGGTC    +     + CLC P F G  C
Sbjct: 243 CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDC 273



 Score =  123 bits (308), Expect = 3e-28
 Identities = 79/226 (34%), Positives = 102/226 (45%), Gaps = 21/226 (9%)

Query: 42   VCRCQPGWQGPLC----DQCVTSPGCLHGLCG-EPG--QCICTDGWDGELCDRDVRACSS 94
            +C+C PG+ G  C    D C + P   HG C  +PG   C C  G+ G  C+ DV  C  
Sbjct: 953  LCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLD 1012

Query: 95   APCANNGT--CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
             PC   GT  C SL +  Y C C PG++G+ C+ +  PC  +  PC HGGTC    G   
Sbjct: 1013 QPCHPTGTAACHSLANAFY-CQCLPGHTGQWCEVEIDPC--HSQPCFHGGTCEATAGSPL 1069

Query: 153  HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI---GGDFRCRCPAGFIDKTCSRPV 209
               C CP GF G  C   A SC  + C + G+C      G   RC C +G+    C  P 
Sbjct: 1070 GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPP 1129

Query: 210  T--NCA-SSPCQNGGTCLQHTQV---SYECLCKPEFTGLTCVKKRA 249
                C   SPC   G+C + T +    + C C     G  C K  A
Sbjct: 1130 APKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGA 1175



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 29/86 (33%), Positives = 36/86 (41%), Gaps = 14/86 (16%)

Query: 176 PNPCENDGVCTDIG-GDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV----- 229
           P PC N G C  +  G   C+C  GF+ +TC  P     +  CQNGG+C           
Sbjct: 32  PEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91

Query: 230 --------SYECLCKPEFTGLTCVKK 247
                   S+ C C P FTG  C  K
Sbjct: 92  SSPSPLTPSFLCTCLPGFTGERCQAK 117


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  143 bits (360), Expect = 3e-34
 Identities = 81/230 (35%), Positives = 109/230 (47%), Gaps = 22/230 (9%)

Query: 24  AECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSP-----GCLHGLCGEPGQC 74
           A C  A   Q+G    +  C C PG+ G LC    D C+  P      C+  L G    C
Sbjct: 362 ASCIDANEKQDG---SNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFT--C 416

Query: 75  ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
            C +G+ G  C+  V  C+S+PC NNGTC  +D   + C+C+PG++G  C +    C + 
Sbjct: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQLIDFCAL- 474

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
            SPC HG TC       +   CLC PG+ G +CE   N C   PC N   C D+   + C
Sbjct: 475 -SPCAHG-TC---RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529

Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C A +    C      CA+  C NG TC     ++  C+C P FTG  C
Sbjct: 530 VCLAEYKGTHCELYKDPCANVSCLNGATC-DSDGLNGTCICAPGFTGEEC 578



 Score =  142 bits (357), Expect = 7e-34
 Identities = 74/201 (36%), Positives = 95/201 (47%), Gaps = 24/201 (11%)

Query: 22  YGAECFPACNP-------QNGFCEDDNV---CRCQPGWQGPLCDQ----CVTSPGCLHGL 67
           +G+ C    +P        NG C  D V   C C PG+ GP C Q    C  SP C HG 
Sbjct: 423 FGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-CAHGT 481

Query: 68  CGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC 124
           C   G   +C+C  G+ G  C+ +   C SAPC N  TC  L +G YEC C   Y G  C
Sbjct: 482 CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCLAEYKGTHC 540

Query: 125 QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGV 184
           +    PC      C +G TC  D     + +C+C PGF+G  C+I  N C  NPC + G 
Sbjct: 541 ELYKDPCA--NVSCLNGATCDSD---GLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595

Query: 185 CTDIGGDFRCRCPAGFIDKTC 205
           C D    + C CP G++   C
Sbjct: 596 CLDQPNGYNCHCPHGWVGANC 616



 Score =  138 bits (348), Expect = 7e-33
 Identities = 72/207 (34%), Positives = 102/207 (49%), Gaps = 12/207 (5%)

Query: 42  VCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNG 101
           V  C PG       +C     C          C C + + G  C+ +  AC   PC NN 
Sbjct: 304 VSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNA 362

Query: 102 TCVSL----DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCL 157
           +C+      D   + C C PGY+G+ CQ K   C+++  PC++G TC+      S  +C 
Sbjct: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD--PCRNGATCISS---LSGFTCQ 417

Query: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
           CP G+ G+ CE   + C  +PC+N+G C   G  F C C  GF   TC++ +  CA SPC
Sbjct: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC 477

Query: 218 QNGGTCLQHTQVSYECLCKPEFTGLTC 244
            + GTC +    SY+CLC P + GL C
Sbjct: 478 AH-GTC-RSVGTSYKCLCDPGYHGLYC 502



 Score =  117 bits (292), Expect = 2e-26
 Identities = 67/218 (30%), Positives = 99/218 (45%), Gaps = 13/218 (5%)

Query: 97  CANNGTCVSL-DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD--DEGRASH 153
           C+  G C +   +  + C+C   Y G  C++ D        PCQ+  +C+D  ++   S+
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA---CQRKPCQNNASCIDANEKQDGSN 375

Query: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
            +C+C PG++G  C+   + C  +PC N   C      F C+CP G+    C   V  CA
Sbjct: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435

Query: 214 SSPCQNGGTCLQHTQVSYECLCKPEFTGLTC---VKKRALSPQQVTRLPSGYGLAYR--L 268
           SSPCQN GTC     V + C C P FTG TC   +   ALSP       S  G +Y+   
Sbjct: 436 SSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRS-VGTSYKCLC 493

Query: 269 TPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAIC 306
            PG H L  ++  +  L            L+   + +C
Sbjct: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 13/88 (14%)

Query: 92  CSSAPCANNGTCVS-----------LDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
           C++ PC N G C S             +  Y C+C  G SG +CQ    PC  N  PC H
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN--PCHH 105

Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCE 168
           G         +    C+C  G+ G  CE
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 16/92 (17%)

Query: 129 GPCVINGSPCQHGGTCVD-DEGRASHA--------SCLCPPGFSGNFCEIVANSCTPNPC 179
           GPC     PC++GG C    E    H         SC CP G SG  C++VA+ C  NPC
Sbjct: 46  GPCA--AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103

Query: 180 ENDGVCTDIGGD----FRCRCPAGFIDKTCSR 207
            + G C+         + C C  G+    C +
Sbjct: 104 HH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 24/111 (21%)

Query: 174 CTPNPCENDGVCTDI----------GGD--FRCRCPAGFIDKTCSRPVTNCASSPCQNGG 221
           C   PC N GVCT             G+  + C CPAG     C      CAS+PC +G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 222 TCLQHTQVS--YECLCKPEFTGLTCVK----------KRALSPQQVTRLPS 260
                +  S  Y C+C   + G  C +            +++P+Q+  +P+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPA 158



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 30/89 (33%), Positives = 37/89 (41%), Gaps = 7/89 (7%)

Query: 43  CRCQPGWQGPLCDQCVTSPGCLHGLCGEPG-QCICTDGWDGELCDRDVRACSSAPCANNG 101
           C  QP   G +C              GEPG  C C  G  G  C      C+S PC ++G
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106

Query: 102 TC----VSLDDGLYECSCAPGYSGKDCQK 126
            C     S  DG Y C C  GY G +C++
Sbjct: 107 NCSSSSSSSSDG-YLCICNEGYEGPNCEQ 134



 Score = 29.6 bits (65), Expect = 4.8
 Identities = 10/31 (32%), Positives = 17/31 (54%)

Query: 30  CNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60
           C+  +    D  +C C  G++GP C+Q + S
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  142 bits (357), Expect = 7e-34
 Identities = 75/199 (37%), Positives = 95/199 (47%), Gaps = 21/199 (10%)

Query: 51  GPLCDQCVTSPGCLHGLCGEPGQ-CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDG 109
           G   D CVT         G P   C C  G+ G  C  DV  C+S PC N GTC      
Sbjct: 282 GKCIDDCVT---------GNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTH-GIN 331

Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
            + C C  G+ G  C+    PC  +   CQHGG C  + G    A C+C  G++G  CE+
Sbjct: 332 SFRCQCPAGFGGPTCETAQSPC--DTKECQHGGQCQVENG---SAVCVCQAGYTGAACEM 386

Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC---SRPVTN-CASSPCQNGGTCLQ 225
             + C+P+PC N G C D+ G++ C C   F    C     PV + C S+PC NGGTC+ 
Sbjct: 387 DVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVD 446

Query: 226 HTQVSYECLCKPEFTGLTC 244
             Q  Y C C   F GL C
Sbjct: 447 ADQ-GYVCECPEGFMGLDC 464



 Score =  135 bits (341), Expect = 5e-32
 Identities = 78/227 (34%), Positives = 110/227 (48%), Gaps = 18/227 (7%)

Query: 30  CNPQNG---FCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGELC 85
           C  +NG      +  +C+C  G+ G LC+  +T+  C ++  C + G C+   G    +C
Sbjct: 472 CECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC 531

Query: 86  DRDVRA-------CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
             D  A       C S PC N G+C + DD  Y C C  G+ GK C+K   P + +  PC
Sbjct: 532 HTDHNASHSLPSPCDSDPCFNGGSCDAHDDS-YTCECPRGFHGKHCEKAR-PHLCSSGPC 589

Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFCEI-VANSCTPNPCENDGVCTDIGGDFRCRCP 197
           ++GGTC +  G      C CP  F+G  CEI   +SC   PC N G C    G ++C CP
Sbjct: 590 RNGGTCKEAGGEYH---CSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCP 646

Query: 198 AGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            GF  + C    + C  SPC NGGTC +     + C C+  + G  C
Sbjct: 647 PGFSGRHCEIAPSPCFRSPCVNGGTC-EDRDTDFFCHCQAGYMGRRC 692



 Score =  126 bits (316), Expect = 4e-29
 Identities = 87/234 (37%), Positives = 110/234 (47%), Gaps = 35/234 (14%)

Query: 35  GFCEDDN---VCRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPGQCICTDGWDG 82
           G C+ +N   VC CQ G+ G  C    D C   P CL+G     L G    C+C + + G
Sbjct: 362 GQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDP-CLNGGSCVDLVGN-YTCLCAEPFKG 419

Query: 83  ELCDRDVR----ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
             C+        AC SAPC N GTCV  D G Y C C  G+ G DC+++    V +   C
Sbjct: 420 LRCETGDHPVPDACLSAPCHNGGTCVDADQG-YVCECPEGFMGLDCRER----VPDDCEC 474

Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFC--EIVANSCTPN-PCENDGVCTDIGGDFRCR 195
           ++GG C+     A+   C CP GF G  C  EI A  C  N  C + G C + GG + C 
Sbjct: 475 RNGGRCLG----ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCV 530

Query: 196 CPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
           C     D   S  + + C S PC NGG+C  H   SY C C   F G  C K R
Sbjct: 531 C---HTDHNASHSLPSPCDSDPCFNGGSCDAHDD-SYTCECPRGFHGKHCEKAR 580



 Score =  121 bits (304), Expect = 9e-28
 Identities = 78/266 (29%), Positives = 102/266 (38%), Gaps = 69/266 (25%)

Query: 43  CRCQPGWQGPLC-----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSS 94
           C C   + G  C     D C + P    G C       +C C  G+ G  C+     C  
Sbjct: 604 CSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFR 663

Query: 95  APCANNGTCVSLDDGLYECSCAPGYSGK------DC----QKKDGPCVINGS-------- 136
           +PC N GTC   D   + C C  GY G+      DC    + K      NG+        
Sbjct: 664 SPCVNGGTCEDRDTDFF-CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALY 722

Query: 137 --------------------------------------PCQHGGTCVDDEGRASHASCLC 158
                                                 PC HGG+C D   R +   CLC
Sbjct: 723 ACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQD---RVAGYLCLC 779

Query: 159 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
             G+ G  CE+  + C  +PC N G C ++ G + CRCPAGF+   C   V  C SSPCQ
Sbjct: 780 STGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQ 839

Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTC 244
           +GG C +    +Y C+C   F G  C
Sbjct: 840 HGGRC-ESGGGAYLCVCPESFFGYHC 864



 Score =  120 bits (302), Expect = 2e-27
 Identities = 72/233 (30%), Positives = 98/233 (42%), Gaps = 36/233 (15%)

Query: 15  LAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQC 74
           L F  +  GA    AC+          +  CQP                 HG+  EP QC
Sbjct: 709 LRFNGTRLGAVALYACDRGYSLSAPSRIRVCQP-----------------HGVWSEPPQC 751

Query: 75  ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
           +            ++  C S PC + G+C     G Y C C+ GY G  C+ +   C   
Sbjct: 752 L------------EIDECRSQPCLHGGSCQDRVAG-YLCLCSTGYEGAHCELERDEC--R 796

Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
             PC++GG+C +  G      C CP GF G  CE   ++C  +PC++ G C   GG + C
Sbjct: 797 AHPCRNGGSCRNLPGAYV---CRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLC 853

Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
            CP  F    C      C SSPC   G CL  +  S+ C CK  +TG  C K+
Sbjct: 854 VCPESFFGYHCETVSDPCFSSPCGGRGYCLA-SNGSHSCTCKVGYTGEDCAKE 905



 Score =  112 bits (279), Expect = 7e-25
 Identities = 56/164 (34%), Positives = 73/164 (44%), Gaps = 10/164 (6%)

Query: 85  CDRDVRACSSA-PCANNGTCVS---LDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
           C      C +  PC N G C+      +  Y CSC  G++G+ C      C     PCQ+
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECA--SQPCQN 322

Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF 200
           GGTC       +   C CP GF G  CE   + C    C++ G C    G   C C AG+
Sbjct: 323 GGTCTHG---INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGY 379

Query: 201 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
               C   V +C+  PC NGG+C+     +Y CLC   F GL C
Sbjct: 380 TGAACEMDVDDCSPDPCLNGGSCVDLVG-NYTCLCAEPFKGLRC 422



 Score =  106 bits (265), Expect = 3e-23
 Identities = 81/285 (28%), Positives = 104/285 (36%), Gaps = 75/285 (26%)

Query: 32  PQNGFCEDDN-----VCRCQPGWQGPLCDQCVTSPGCLHGLCG---EPGQCICTDGWDGE 83
           P  G+C +       VC         L   C + P    G C    +   C C  G+ G+
Sbjct: 515 PDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGK 574

Query: 84  LCDRD-VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHG 141
            C++     CSS PC N GTC     G Y CSC   ++G+ C+  K   C     PC +G
Sbjct: 575 HCEKARPHLCSSGPCRNGGTCKEAG-GEYHCSCPYRFTGRHCEIGKPDSCA--SGPCHNG 631

Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF--------- 192
           GTC    G+     C CPPGFSG  CEI  + C  +PC N G C D   DF         
Sbjct: 632 GTCFHYIGKYK---CDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYM 688

Query: 193 --RCR------------------------------CPAGFIDKTCSR------------- 207
             RC+                              C  G+     SR             
Sbjct: 689 GRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEP 748

Query: 208 ----PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
                +  C S PC +GG+C Q     Y CLC   + G  C  +R
Sbjct: 749 PQCLEIDECRSQPCLHGGSC-QDRVAGYLCLCSTGYEGAHCELER 792



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 9/63 (14%)

Query: 117  PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI----VAN 172
            P +  KD     G C  N  PCQ+GGTCV   G  +H SC C PGF G  CE+    V+ 
Sbjct: 1297 PEHGSKDIGNVPGNCSEN--PCQNGGTCVP--GADAH-SCDCGPGFKGRRCELACIKVSR 1351

Query: 173  SCT 175
             CT
Sbjct: 1352 PCT 1354



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 10/62 (16%)

Query: 92   CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ----KKDGPCV-----INGSPCQHGG 142
            CS  PC N GTCV   D  + C C PG+ G+ C+    K   PC          P   GG
Sbjct: 1311 CSENPCQNGGTCVPGADA-HSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369

Query: 143  TC 144
             C
Sbjct: 1370 VC 1371



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 27/92 (29%), Positives = 36/92 (39%), Gaps = 14/92 (15%)

Query: 170  VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC-------SRPVTNCASS----PCQ 218
            V  +C+ NPC+N G C        C C  GF  + C       SRP T   S     P  
Sbjct: 1307 VPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVW 1366

Query: 219  NGGTC---LQHTQVSYECLCKPEFTGLTCVKK 247
             GG C    +     ++ +C  E    T +KK
Sbjct: 1367 EGGVCHHVYKRVYRVHQDICFKESCESTSLKK 1398


>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
          Length = 236

 Score =  140 bits (352), Expect = 2e-33
 Identities = 74/207 (35%), Positives = 99/207 (47%), Gaps = 17/207 (8%)

Query: 43  CRCQPGWQGPLC--------DQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVR--AC 92
           C+C  G+ G  C        ++C     C+         C C  G+ GE C         
Sbjct: 12  CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCF 71

Query: 93  SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
            S PC N GTC  L    YEC+C  G++GK+CQ  D  C+ +  PC +G TC      A+
Sbjct: 72  VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSH--PCANGSTCTTV---AN 125

Query: 153 HASCLCPPGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
             SC C  GF+G  CE   N C  P  C++ G C ++ G ++C+C  GF  + C      
Sbjct: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185

Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPE 238
           CA SPC NGGTC Q    ++EC C PE
Sbjct: 186 CAPSPCVNGGTCRQTGDFTFECNCLPE 212



 Score =  120 bits (301), Expect = 2e-27
 Identities = 69/177 (38%), Positives = 91/177 (51%), Gaps = 11/177 (6%)

Query: 72  GQCICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDD-GLYECSCAPGYSGKDCQKKDG 129
           G C C +G+ GE C  RD   C    C N GTCV+    G   C CA G++G+DCQ    
Sbjct: 10  GYCKCPEGFLGEYCQHRD--PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67

Query: 130 -PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI 188
            PC ++  PC +GGTC     R ++  C C  GF+G  C+   ++C  +PC N   CT +
Sbjct: 68  HPCFVS-RPCLNGGTC-HMLSRDTY-ECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123

Query: 189 GGDFRCRCPAGFIDKTCSRPVTNC-ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
              F C+C  GF  + C   V  C     CQ+GGTCL +   SY+C C   FTG  C
Sbjct: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCL-NLPGSYQCQCLQGFTGQYC 179


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  135 bits (341), Expect = 5e-32
 Identities = 89/250 (35%), Positives = 118/250 (47%), Gaps = 35/250 (14%)

Query: 24   AECFPAC-NP--QNGFCEDDNV----CRCQPGWQGPLCD----QCVTSPGCLHG-LC--- 68
            A+C P   NP   +G C  D V    C C  G++G  CD     C+++P C HG  C   
Sbjct: 917  AKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLK 975

Query: 69   -GEPGQ--CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKD 123
             GE     CIC DG++GE C+ +V  C    C NN TCV   DG+  Y C C P Y+G+ 
Sbjct: 976  EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV---DGINNYTCLCPPEYTGEL 1032

Query: 124  CQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDG 183
            C++K   C  + +PCQH   C+          C C PG+ G  C+I  + C  N C+N  
Sbjct: 1033 CEEKLDFCAQDLNPCQHDSKCILTP---KGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA 1089

Query: 184  VCTDIGGDFRCRCPAGFIDKTC--SRPVTNCASSP-----CQNGGTCLQHTQVSYECLCK 236
             CTD    + C CP G+    C  S P+    +SP     CQNG  C+        C C 
Sbjct: 1090 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPI-CQCL 1148

Query: 237  PEFTGLTCVK 246
            P + G  C K
Sbjct: 1149 PGYQGEKCEK 1158



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 57/183 (31%), Positives = 81/183 (44%), Gaps = 12/183 (6%)

Query: 71   PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVS---LDDGLYECSCAPGYSGKDCQKK 127
            P  C C   W  +    + +    A CA  G       L     + +C  G    +   K
Sbjct: 860  PLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ-GPVDVNILAK 918

Query: 128  DGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
              PC+ N  PC++ GTC  D        C CP GF G  C++  ++C  NPC++ G C  
Sbjct: 919  CNPCLSN--PCKNDGTCNSDP--VDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHL 974

Query: 188  IGGD---FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
              G+   F C C  GF  + C   V +C  + C+N  TC+     +Y CLC PE+TG  C
Sbjct: 975  KEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN-NYTCLCPPEYTGELC 1033

Query: 245  VKK 247
             +K
Sbjct: 1034 EEK 1036



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 39/121 (32%), Positives = 51/121 (42%), Gaps = 22/121 (18%)

Query: 28   PACNP------QNGFCEDDN----VCRCQPGWQGPLCDQCVTSP----GCLHGLC----G 69
            P C P       +G C+  +     C CQ GW GPLCDQ    P     C+HG C     
Sbjct: 1331 PGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINA 1390

Query: 70   EPGQCICTDGWDGELCDRD---VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK 126
                C C +G  G LCD +      C +  C  +G C     G   C C+ GY+G  C +
Sbjct: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSGLGQPYCECSSGYTGDSCDR 1449

Query: 127  K 127
            +
Sbjct: 1450 E 1450



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 52/205 (25%), Positives = 79/205 (38%), Gaps = 32/205 (15%)

Query: 52   PLCDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANN----GTC 103
            P C+ C     C HG C    Q    C C +GW G LCD+     ++ PC  N    GTC
Sbjct: 1331 PGCEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQR----TNDPCLGNKCVHGTC 1385

Query: 104  VSLDDGLYECSCAPGYSGKDCQKKD---GPCVINGSPCQHGGTCVDDEGRASHASCLCPP 160
            + ++   Y C C  G+ G  C +++    PC      C+HG   +   G+     C C  
Sbjct: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPC--QAIKCKHGKCRLSGLGQ---PYCECSS 1440

Query: 161  GFSGNFCEIVANSCTPNPC-------ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
            G++G+ C+    SC            +    C       R  C  G     C  P+ +  
Sbjct: 1441 GYTGDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKR 1499

Query: 214  ---SSPCQNGGTCLQHTQVSYECLC 235
               S  C +G + +   +   +C C
Sbjct: 1500 RKYSFECTDGSSFVDEVEKVVKCGC 1524



 Score = 36.2 bits (82), Expect = 0.051
 Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 3/72 (4%)

Query: 192  FRCRCPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRAL 250
            F C C  G++   C +   + C  + C +G TCL     SY C C     G+ C ++  L
Sbjct: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412

Query: 251  -SPQQVTRLPSG 261
             +P Q  +   G
Sbjct: 1413 FNPCQAIKCKHG 1424



 Score = 28.9 bits (63), Expect = 8.1
 Identities = 12/37 (32%), Positives = 20/37 (54%), Gaps = 8/37 (21%)

Query: 23   GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVT 59
            GA+C    N        + +C+C PG+QG  C++ V+
Sbjct: 1133 GAQCIVRIN--------EPICQCLPGYQGEKCEKLVS 1161


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  135 bits (340), Expect = 6e-32
 Identities = 69/199 (34%), Positives = 96/199 (48%), Gaps = 14/199 (7%)

Query: 54   CDQCVTSPGCLHGLCG----EPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD-- 107
            CD C++SP    G C     E  +C C  G+ G  C+  + +CSS PC N GTC + +  
Sbjct: 926  CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985

Query: 108  DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC 167
            D  + CSC  G+ G  C      CV +   C +GG CVD  G   + +C CP  + G  C
Sbjct: 986  DAPFTCSCPTGFEGPTCGVNTDDCVDHA--CANGGVCVDGVG---NYTCQCPLQYEGKAC 1040

Query: 168  EIVANSCTP--NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQ 225
            E + + C+P  NPC+++  C       RC C  G+    CS    +C    CQNG  C+ 
Sbjct: 1041 EQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMD 1100

Query: 226  HTQVSYECLCKPEFTGLTC 244
                SY CLC   ++G  C
Sbjct: 1101 EVN-SYSCLCAEGYSGQLC 1118



 Score =  121 bits (303), Expect = 1e-27
 Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 25/241 (10%)

Query: 26   CFPACNPQNGFCEDDNV----CRCQPGWQGPLC----DQCVTSP----GCLHGLCGE--P 71
            C  +     G C +D +    C C  G++G  C    D C + P    G  H   GE  P
Sbjct: 929  CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988

Query: 72   GQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC 131
              C C  G++G  C  +   C    CAN G CV    G Y C C   Y GK C++    C
Sbjct: 989  FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLC 1047

Query: 132  VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
              + +PCQH   CV   G      C C PG++G+ C    + C  + C+N   C D    
Sbjct: 1048 SPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS 1104

Query: 192  FRCRCPAGFIDKTCS------RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCV 245
            + C C  G+  + C        P + C  + CQNG  C+        C C P F G  C 
Sbjct: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV-CQCLPGFGGPECE 1163

Query: 246  K 246
            K
Sbjct: 1164 K 1164



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 69/214 (32%), Positives = 90/214 (42%), Gaps = 35/214 (16%)

Query: 34   NGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLC---GEPG-QCICTDGWDGELCDRDV 89
            N   +D    + +PG   P C+ C     CLHG+C     PG  C C  GW G  CD+  
Sbjct: 1320 NNELQDFTKTQMKPGVV-PGCEPC-RKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA 1377

Query: 90   RA-CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDG---PCVINGSPCQHGGTCV 145
               C    C + G CV LD   Y C C  GYSG  C +      PC   G  C H G C 
Sbjct: 1378 DGPCHGHKCVH-GQCVPLDALSYSCQCQDGYSGALCNQAGALAEPC--RGLQCLH-GHCQ 1433

Query: 146  DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
                + +H  C+C PGFSG  CE        + C  D V      DF  +   G+     
Sbjct: 1434 ASGTKGAH--CVCDPGFSGELCE------QESECRGDPV-----RDFH-QVQRGYAICQT 1479

Query: 206  SRPVT--NCASSPCQNGGTC----LQHTQVSYEC 233
            +RP++   C  S C   G C    L+  + ++EC
Sbjct: 1480 TRPLSWVECRGS-CPGQGCCQGLRLKRRKFTFEC 1512



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 39/133 (29%), Positives = 47/133 (35%), Gaps = 42/133 (31%)

Query: 113  CSCAPGYSGKDC-QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
            C C  G+ G  C Q  DGPC  +G  C HG  CV  +  A   SC C  G+SG  C    
Sbjct: 1362 CHCEAGWVGLHCDQPADGPC--HGHKCVHG-QCVPLD--ALSYSCQCQDGYSGALCN--- 1413

Query: 172  NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
                                      AG + + C      C    CQ  GT   H     
Sbjct: 1414 -------------------------QAGALAEPCRG--LQCLHGHCQASGTKGAH----- 1441

Query: 232  ECLCKPEFTGLTC 244
             C+C P F+G  C
Sbjct: 1442 -CVCDPGFSGELC 1453



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 194  CRCPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALS 251
            C C AG++   C +P    C    C +G  C+    +SY C C+  ++G  C +  AL+
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQAGALA 1419


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  125 bits (315), Expect = 5e-29
 Identities = 59/156 (37%), Positives = 77/156 (49%), Gaps = 5/156 (3%)

Query: 91   ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGR 150
            AC S+PC NNGTC      LY C+C   Y GKDC      C+ N  PCQHGGTC   +  
Sbjct: 919  ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQN--PCQHGGTCHLSDSH 976

Query: 151  ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT 210
                SC CP GF G  CEI  + C  N CEN+  C D   ++ C CP  +  + C   + 
Sbjct: 977  KDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036

Query: 211  NCAS--SPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            +C    + CQ+   C+      + C C P ++G  C
Sbjct: 1037 HCVPELNLCQHEAKCIP-LDKGFSCECVPGYSGKLC 1071



 Score =  125 bits (313), Expect = 8e-29
 Identities = 79/246 (32%), Positives = 105/246 (42%), Gaps = 34/246 (13%)

Query: 26   CFPACNPQNGFCEDDNV----CRCQPGWQGPLC----DQCVTSPGCLHG-LCG------E 70
            C  +    NG C  D V    C C   ++G  C    + C+ +P C HG  C       +
Sbjct: 920  CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSDSHKD 978

Query: 71   PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKD 128
               C C  G++G+ C+ +   C    C NN TCV   DG+  Y C C P Y+G+ C +  
Sbjct: 979  GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCV---DGINNYVCICPPNYTGELCDEVI 1035

Query: 129  GPCVINGSPCQHGGTCVD-DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
              CV   + CQH   C+  D+G     SC C PG+SG  CE   + C  + C +   C D
Sbjct: 1036 DHCVPELNLCQHEAKCIPLDKG----FSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091

Query: 188  IGGDFRCRCPAGFIDKTCSRP-------VTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240
                + C CP GF    C  P        + C    CQNG  C+   Q    C C P F 
Sbjct: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIV-VQQEPTCRCPPGFA 1150

Query: 241  GLTCVK 246
            G  C K
Sbjct: 1151 GPRCEK 1156



 Score =  113 bits (282), Expect = 3e-25
 Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 31/207 (14%)

Query: 22   YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPG 72
            +G  C  + + ++GF      C C  G++G  C+          C  +  C+ G+     
Sbjct: 966  HGGTCHLSDSHKDGFS-----CSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYV- 1019

Query: 73   QCICTDGWDGELCDRDVRACSSAP--CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
             CIC   + GELCD  +  C      C +   C+ LD G + C C PGYSGK C+  +  
Sbjct: 1020 -CICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDD 1077

Query: 131  CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCE-------IVANSCTPNPCENDG 183
            CV +   C+HG  CVD     +  +C CP GFSG FCE       +  + C    C+N  
Sbjct: 1078 CVAH--KCRHGAQCVDT---INGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132

Query: 184  VCTDIGGDFRCRCPAGFIDKTCSRPVT 210
             C  +  +  CRCP GF    C + +T
Sbjct: 1133 QCIVVQQEPTCRCPPGFAGPRCEKLIT 1159



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 46/114 (40%), Positives = 61/114 (53%), Gaps = 16/114 (14%)

Query: 33   QNGFC----EDDNVCRCQPGWQGPLCDQCVTSP----GCLHGLC---GEPGQCICTDGWD 81
            ++G C    +D  VC C+PGW GPLCDQ    P     C HG C   G    C C +G+ 
Sbjct: 1339 KHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYG 1398

Query: 82   GELCDR---DVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
            G+LCD       ACS+  C ++G C   D G   C C PG+SG+ CQ ++ PC+
Sbjct: 1399 GDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCL 1450



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 29/76 (38%), Positives = 41/76 (53%), Gaps = 3/76 (3%)

Query: 172 NSCTPNPCENDGVCT-DIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC--LQHTQ 228
           N+C  +PC+N+G CT D    +RC CP  +  K C+ P+  C  +PCQ+GGTC      +
Sbjct: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977

Query: 229 VSYECLCKPEFTGLTC 244
             + C C   F G  C
Sbjct: 978 DGFSCSCPLGFEGQRC 993



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 10/120 (8%)

Query: 92   CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC-QKKDGPCVINGSPCQHGGTCVDDEGR 150
            C S     +G C S++     C C PG++G  C Q+   PC+  G  C H G CV     
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL--GHRCHH-GKCV---AT 1385

Query: 151  ASHASCLCPPGFSGNFCE---IVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
             +   C C  G+ G+ C+     AN+C+   C +        G+  C C  GF  + C +
Sbjct: 1386 GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 38/132 (28%), Positives = 55/132 (41%), Gaps = 12/132 (9%)

Query: 138  CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANS-CTPNPCENDGVCTDIGGDFRCRC 196
            C+HG  C   E       C C PG++G  C+  A   C  + C + G C   G  + C+C
Sbjct: 1338 CKHG-LCRSVE--KDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKC 1393

Query: 197  PAGFIDKTCSRP---VTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
              G+    C         C++  C +G  C    Q    CLC+P F+G  C ++     Q
Sbjct: 1394 AEGYGGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQ 1452

Query: 254  ---QVTRLPSGY 262
               +V R   GY
Sbjct: 1453 VVREVIRRQKGY 1464


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score =  117 bits (294), Expect = 1e-26
 Identities = 71/217 (32%), Positives = 98/217 (45%), Gaps = 38/217 (17%)

Query: 35   GFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCICTDGWDGELCDRDVRACS 93
            G C   ++C+C+PGW GP C   +  P CL+ G C +P  C+C +G+ GE C     A  
Sbjct: 1402 GQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQ---NAFC 1458

Query: 94   SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH 153
              PC N G C+  +     C C  GY+G+  QK      I    C +GG CV        
Sbjct: 1459 HPPCKNGGHCMRNN----VCVCREGYTGRRFQKS-----ICDPTCMNGGKCV------GP 1503

Query: 154  ASCLCPPGFSGNFCEIVANSCTP---NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT 210
            ++C CP G+SG  C       TP     C+N G C        C CP+ +    C  P+ 
Sbjct: 1504 STCSCPSGWSGKRCN------TPICLQKCKNGGECI---APSICHCPSSWEGVRCQIPIC 1554

Query: 211  NCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
            N     C  GG C+        C C+ E++G+ C KK
Sbjct: 1555 N---PKCLYGGRCI----FPNVCSCRTEYSGVKCEKK 1584



 Score =  104 bits (259), Expect = 2e-22
 Identities = 62/206 (30%), Positives = 93/206 (45%), Gaps = 32/206 (15%)

Query: 37   CEDDNVCRCQPGWQGPLCDQCVTSPGCL-HGLCGEPGQCICTDGWDGELCDRDVRACSSA 95
            C   N+C+C+PG+ G  C   +  P C  HG C +P  C C  G  G  CD +     + 
Sbjct: 1308 CVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDEE---HCNP 1364

Query: 96   PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
            PC + GTC++ +     C+C  G+ G  C+      ++    C++GG C+  +       
Sbjct: 1365 PCQHGGTCLAGN----LCTCPYGFVGPRCE-----TMVCNRHCENGGQCLTPD------I 1409

Query: 156  CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
            C C PG+ G  C      C P  C N G C        C CP GF  + C     +    
Sbjct: 1410 CQCKPGWYGPTCSTAL--CDP-VCLNGGSCNKPN---TCLCPNGFFGEHCQNAFCH---P 1460

Query: 216  PCQNGGTCLQHTQVSYECLCKPEFTG 241
            PC+NGG C+++      C+C+  +TG
Sbjct: 1461 PCKNGGHCMRNN----VCVCREGYTG 1482



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 65/257 (25%), Positives = 83/257 (32%), Gaps = 82/257 (31%)

Query: 54   CDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDG 109
            CD C+    C+      PG     C+C  G+ G LC+ D+  C S PC            
Sbjct: 1181 CD-CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGFHS- 1238

Query: 110  LYECSCAPGY-------------------SGKDCQKKDGPCVINGS-------------- 136
             Y C C P                     S K   K++      G               
Sbjct: 1239 -YSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTI 1297

Query: 137  ---PCQHGGTCVD--------------------DEGRASHASCL------CPPGFSGNFC 167
               PC     CV                     D    +H  C+      C PG  G  C
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATC 1357

Query: 168  EIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT 227
            +     C P PC++ G C  + G+  C CP GF+   C   V N     C+NGG CL   
Sbjct: 1358 D--EEHCNP-PCQHGGTC--LAGNL-CTCPYGFVGPRCETMVCN---RHCENGGQCL--- 1405

Query: 228  QVSYECLCKPEFTGLTC 244
                 C CKP + G TC
Sbjct: 1406 -TPDICQCKPGWYGPTC 1421



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 55/215 (25%), Positives = 74/215 (34%), Gaps = 58/215 (26%)

Query: 85   CDRDVRAC-----SSAPCANNGTCVS-----LDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
            CD + R        S  C N G+CVS        G+Y C C PG+ G  C+     C  N
Sbjct: 1166 CDAETRVTIEVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSN 1225

Query: 135  GSPCQHGGTCVDDEGRASHASCLCPP----------GFSGNFCEIVANSCTPNPCEND-- 182
              PC  G       G  S+ SC CPP           F+     +  +  + N  E+D  
Sbjct: 1226 --PCGLGSYI---SGFHSY-SCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKN 1279

Query: 183  ----------------GVCTDIGGDFR-------CRCPAGFIDKTCSRPVTNCASSPCQN 219
                             +C    G  R       C+C  G+I   C    T      C+N
Sbjct: 1280 AQGRKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQ---TALCDPDCKN 1336

Query: 220  GGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQ 254
             G C++       C C P   G TC ++    P Q
Sbjct: 1337 HGKCIKPN----ICQCLPGHGGATCDEEHCNPPCQ 1367



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 2/66 (3%)

Query: 26   CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG-LCGEPGQCICTDGWDGEL 84
            C   C    G C   ++C C   W+G  C   + +P CL+G  C  P  C C   + G  
Sbjct: 1522 CLQKCK-NGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVK 1580

Query: 85   CDRDVR 90
            C++ ++
Sbjct: 1581 CEKKIQ 1586


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  117 bits (294), Expect = 1e-26
 Identities = 89/269 (33%), Positives = 107/269 (39%), Gaps = 55/269 (20%)

Query: 21  TYGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCD----------QCVTSPGCLH--G 66
           T+G  C   C   NG  C   D  C C PGW+G  C+           C     C H  G
Sbjct: 490 TWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADG 549

Query: 67  LCGEPGQCICTDGWDGELCDRDVRACS--------SAPC-ANNGTCVSLDDGLYECSCAP 117
                G C C  GW G  CD     C+        S PC   NG   S DDG+  C CAP
Sbjct: 550 CHPTTGHCRCLPGWSGVHCDS---VCAEGRWGPNCSLPCYCKNGASCSPDDGI--CECAP 604

Query: 118 GYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIV----- 170
           G+ G  CQ+   P        Q    CV   G   H +  C C PGF+G  C  V     
Sbjct: 605 GFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGR 664

Query: 171 -----ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV------TNCA-SSPCQ 218
                A  CT   C N+G C  I  D  C+C  G+I   CS+P        NC  +  C 
Sbjct: 665 FGKNCAGICT---CTNNGTCNPI--DRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCH 719

Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
           NG  C   +    EC C P +TGL C ++
Sbjct: 720 NGAFC---SAYDGECKCTPGWTGLYCTQR 745



 Score =  111 bits (278), Expect = 1e-24
 Identities = 84/268 (31%), Positives = 110/268 (41%), Gaps = 58/268 (21%)

Query: 21  TYGAECFPACNPQNGFCED--DNVCRCQPGWQGPLCD----------QCVTSPGCLH-GL 67
           TYG +C   C  QNG   D     CRC PG+ G  C+          QC     C + G+
Sbjct: 186 TYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGV 245

Query: 68  CGE-PGQCICTDGWDGELC------DRDVRACS-SAPCANNGTCVSLDDGLYECSCAPGY 119
           C    G+C C  GW G +C       R  + CS    C N GTC   D    +C C+PGY
Sbjct: 246 CHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC---DAATGQCHCSPGY 302

Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCE--------- 168
           +G+ CQ  + P    G  C     CV+  G+  H S  CLC  GF+G  CE         
Sbjct: 303 TGERCQ-DECPVGTYGVLCAETCQCVNG-GKCYHVSGACLCEAGFAGERCEARLCPEGLY 360

Query: 169 -IVANSCTPNPCENDGVCTDIGGDFRCR-----------CPAGFIDKTCSRPVTNCASSP 216
            I  +   P   EN   C  + G+  C+           C  GF  + C +  +      
Sbjct: 361 GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICS------ 414

Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           CQNG  C     V+ +C C P F G+ C
Sbjct: 415 CQNGADC---DSVTGKCTCAPGFKGIDC 439



 Score =  108 bits (271), Expect = 6e-24
 Identities = 74/233 (31%), Positives = 97/233 (41%), Gaps = 50/233 (21%)

Query: 44  RCQPGW--QGPLC-DQCVTSPGCLHGLCGEPGQCICTDGWDG----ELCDRD---VRACS 93
           +C PG+   G +C   C     C+HG C  P  C C  GW G      CD D       S
Sbjct: 93  QCCPGFYESGEMCVPHCADK--CVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTS 150

Query: 94  SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK-----DGPCVINGSPCQHGGTCVDDE 148
              C N   C  +      C CA G+ G  C+ +      G        CQ+G TC    
Sbjct: 151 RCQCKNGALCNPITGA---CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVT 207

Query: 149 GRASHASCLCPPGFSGNFCEIVANSCTPN----------PCENDGVCTDIGGDFRCRCPA 198
           G      C CPPG++G FCE   + C P           PC+N GVC  + G+  C CP+
Sbjct: 208 G-----ECRCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPS 257

Query: 199 GFIDKTCSRPV------TNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
           G++   C +P        NC+    C NGGTC      + +C C P +TG  C
Sbjct: 258 GWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC---DAATGQCHCSPGYTGERC 307



 Score =  104 bits (259), Expect = 2e-22
 Identities = 82/262 (31%), Positives = 99/262 (37%), Gaps = 53/262 (20%)

Query: 23  GAECFPACNPQ--NGFCEDDNVCRCQPGWQGPLCD----------QCVTSPGCLHGLCGE 70
           G  C P C  +  +G C   N C+C+PGW G  C            C +   C +G    
Sbjct: 102 GEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCN 161

Query: 71  P--GQCICTDGWDGELC-DRDVRAC------SSAPCANNGTCVSLDDGLYECSCAPGYSG 121
           P  G C C  G+ G  C DR  +            C N  TC   D    EC C PGY+G
Sbjct: 162 PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC---DHVTGECRCPPGYTG 218

Query: 122 KDCQK-----KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC-------EI 169
             C+      K GP      PCQ+GG C    G      C CP G+ G  C         
Sbjct: 219 AFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG-----ECSCPSGWMGTVCGQPCPEGRF 273

Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR--PVTN----CASS-PCQNGGT 222
             N      C N G C    G  +C C  G+  + C    PV      CA +  C NGG 
Sbjct: 274 GKNCSQECQCHNGGTCDAATG--QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGK 331

Query: 223 CLQHTQVSYECLCKPEFTGLTC 244
           C     VS  CLC+  F G  C
Sbjct: 332 CY---HVSGACLCEAGFAGERC 350



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 71/265 (26%), Positives = 93/265 (35%), Gaps = 52/265 (19%)

Query: 21  TYGAECFPACNPQNG--FCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGE-------- 70
           TYG  C   C   NG         C C+ G+ G  C+  +   G     C +        
Sbjct: 315 TYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLEN 374

Query: 71  -------PGQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCA 116
                   G+C C  GW G  C+          AC     C N   C S+     +C+CA
Sbjct: 375 THSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTG---KCTCA 431

Query: 117 PGYSGKDCQKKDGPCVIN--GSPCQHGGTCVDDEGRAS-HASCLCPPGFSGNFCEIVANS 173
           PG+ G DC     PC +   G  C     C +D   +    SC C  G+ G  C I   S
Sbjct: 432 PGFKGIDCST---PCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPS 488

Query: 174 CT-------PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV------TNCAS-SPCQN 219
            T          C N G C  + G   C C  G+  + C  P        NCA    C +
Sbjct: 489 GTWGFGCNLTCQCLNGGACNTLDG--TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546

Query: 220 GGTCLQHTQVSYECLCKPEFTGLTC 244
              C   T     C C P ++G+ C
Sbjct: 547 ADGCHPTTG---HCRCLPGWSGVHC 568



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 49/170 (28%), Positives = 71/170 (41%), Gaps = 28/170 (16%)

Query: 22  YGAECFPACN-PQNGFCED-DNVCRCQPGWQGPLCDQ-CVTS---PGCLH-------GLC 68
           +G  C   C    NG C   D  C+C PGW G  C Q C  +   P C+H         C
Sbjct: 665 FGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC 724

Query: 69  GE-PGQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCAPGYS 120
               G+C CT GW G  C +        + C+    C N   C  +     +C+C  G+ 
Sbjct: 725 SAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG---QCTCRTGFM 781

Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH--ASCLCPPGFSGNFCE 168
           G+ C++K  P    G  C+    C+++     H   +C C PG+ G  C+
Sbjct: 782 GRHCEQK-CPSGTYGYGCRQICDCLNN-STCDHITGTCYCSPGWKGARCD 829



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 41/126 (32%), Positives = 51/126 (40%), Gaps = 24/126 (19%)

Query: 22  YGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCDQ----------CVTSPGCLHGL-C 68
           +G  C   CN  NG FC   D  C+C PGW G  C Q          C     C +G  C
Sbjct: 708 WGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC 767

Query: 69  GE-PGQCICTDGWDGELCDRDVRA------CSS-APCANNGTCVSLDDGLYECSCAPGYS 120
               GQC C  G+ G  C++   +      C     C NN TC   D     C C+PG+ 
Sbjct: 768 DHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTC---DHITGTCYCSPGWK 824

Query: 121 GKDCQK 126
           G  C +
Sbjct: 825 GARCDQ 830



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 16/38 (42%), Positives = 18/38 (47%), Gaps = 2/38 (5%)

Query: 21  TYGAECFPACNPQNGFCEDD--NVCRCQPGWQGPLCDQ 56
           TYG  C   C+  N    D     C C PGW+G  CDQ
Sbjct: 793 TYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  115 bits (289), Expect = 5e-26
 Identities = 80/269 (29%), Positives = 111/269 (41%), Gaps = 63/269 (23%)

Query: 22  YGAECFPACNPQNG--FCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEP-------- 71
           +G  C  +C+ +NG     +D  C C PG++GPLC Q +  PG     C +P        
Sbjct: 571 WGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLC-QRICPPGFYGHGCAQPCPLCVHSS 629

Query: 72  -------GQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCAP 117
                  G C C  G+ G LC++        + C+    CANNGTC  +D     C C P
Sbjct: 630 RPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDG---SCQCFP 686

Query: 118 GYSGKDCQKKD-----GPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC----- 167
           G+ GKDC +       GP   +   C +G +C  ++G     +C C PG++G FC     
Sbjct: 687 GWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDG-----ACHCTPGWTGLFCTQRCP 741

Query: 168 -EIVANSC-TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS---------- 215
                  C     C+N   C  I G  +C C  GF  + C +    CA            
Sbjct: 742 AAFFGKDCGRVCQCQNGASCDHISG--KCTCRTGFTGQHCEQ---RCAPGTFGYGCQQLC 796

Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            C N  TC     V+  C C P F G+ C
Sbjct: 797 ECMNNSTC---DHVTGTCYCSPGFKGIRC 822



 Score =  113 bits (282), Expect = 3e-25
 Identities = 80/274 (29%), Positives = 109/274 (39%), Gaps = 61/274 (22%)

Query: 18  GHSTYGAECFPACNPQ--NGFCEDDNVCRCQPGWQGPLCD----------QCVTSPGCLH 65
           G+   G  C P C  +  +G C   + C C+PGW GP C            C     C +
Sbjct: 91  GYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQN 150

Query: 66  GLCGEP--GQCICTDGWDGELCDR------DVRACS-SAPCANNGTCVSLDDGLYECSCA 116
           G    P  G C+C  G+ G  C+         + C     C +  +C   D    EC CA
Sbjct: 151 GALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASC---DPRAGECLCA 207

Query: 117 PGYSGKDCQKKDGP------CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIV 170
           PGY+G  C++   P      C +   PCQ+GGTC    G      C CPPG++G  C   
Sbjct: 208 PGYTGVYCEELCPPGSHGAHCELR-CPCQNGGTCHHITG-----ECACPPGWTGAVC--- 258

Query: 171 ANSCTPN----------PCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT------NCAS 214
           A  C P           PC + G C  + G  +C C AG++   C            C+ 
Sbjct: 259 AQPCPPGTFGQNCSQDCPCHHGGQCDHVTG--QCHCTAGYMGDRCQEECPFGSFGFQCSQ 316

Query: 215 -SPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
              C NGG C   T     C C+P + G  C ++
Sbjct: 317 HCDCHNGGQCSPTTGA---CECEPGYKGPRCQER 347



 Score =  112 bits (279), Expect = 7e-25
 Identities = 90/268 (33%), Positives = 109/268 (40%), Gaps = 53/268 (19%)

Query: 21  TYGAECFPACNPQNGF-CED-DNVCRCQPGWQGPLCD----------QCVTSPGCLHGLC 68
           T+G  C  +C   NG  C   D  C C PGW G  C+           C     C H   
Sbjct: 484 TWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADG 543

Query: 69  GEP--GQCICTDGWDGELCD------RDVRACS-SAPCANNGTCVSLDDGLYECSCAPGY 119
            +P  G C C  GW G  CD      R    CS S  C N G+C S +DG   C CAPG+
Sbjct: 544 CDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSC-SPEDG--SCECAPGF 600

Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIV------- 170
            G  CQ+   P        Q    CV       H S  C C PGFSG  C  V       
Sbjct: 601 RGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFG 660

Query: 171 ---ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR--------PVTNCASSPCQN 219
              A  C+   C N+G C+ I G   C+C  G+I K CS+        P    A S C N
Sbjct: 661 QDCAQLCS---CANNGTCSPIDGS--CQCFPGWIGKDCSQACPPGFWGPACFHACS-CHN 714

Query: 220 GGTCLQHTQVSYECLCKPEFTGLTCVKK 247
           G +C   +     C C P +TGL C ++
Sbjct: 715 GASC---SAEDGACHCTPGWTGLFCTQR 739



 Score =  110 bits (276), Expect = 2e-24
 Identities = 84/262 (32%), Positives = 106/262 (40%), Gaps = 46/262 (17%)

Query: 21  TYGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCDQ----------CVTSPGCLHG-L 67
           ++GA C   C  QNG  C      C C PGW G +C Q          C     C HG  
Sbjct: 223 SHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQ 282

Query: 68  CGE-PGQCICTDGWDGELCDRDVR------ACSS-APCANNGTCVSLDDGLYECSCAPGY 119
           C    GQC CT G+ G+ C  +         CS    C N G C         C C PGY
Sbjct: 283 CDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGA---CECEPGY 339

Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH---ASCLCPPGFSGNFCE------IV 170
            G  CQ++  P  ++G  C     C  D   + H    +C C PG+SG+ C         
Sbjct: 340 KGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYY 399

Query: 171 ANSC-TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT------NCAS-SPCQNGGT 222
            + C  P  C+N   C  I G   C C  GF+ + C+          NC+S   C NGGT
Sbjct: 400 GDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGT 457

Query: 223 CLQHTQVSYECLCKPEFTGLTC 244
           C   + V   C CK  + GL C
Sbjct: 458 C---SPVDGSCTCKEGWQGLDC 476



 Score =  102 bits (254), Expect = 6e-22
 Identities = 73/237 (30%), Positives = 95/237 (40%), Gaps = 58/237 (24%)

Query: 44  RCQPGW--QGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRA------CSSA 95
           +C PG+   G  C    T   C+HG C  P  C C  GW G  C     +      CS+ 
Sbjct: 87  QCCPGYYESGDFCIPLCTEE-CVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNR 145

Query: 96  PCANNGTCVSLDDGLYECS-----------CAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
               NG   +   G   C+           CAPG  GK CQ    PC      C+HG +C
Sbjct: 146 CQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQL---PC-----QCRHGASC 197

Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPN----------PCENDGVCTDIGGDFRC 194
               G      CLC PG++G +CE     C P           PC+N G C  I G+  C
Sbjct: 198 DPRAG-----ECLCAPGYTGVYCE---ELCPPGSHGAHCELRCPCQNGGTCHHITGE--C 247

Query: 195 RCPAGFIDKTCSRPV------TNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            CP G+    C++P        NC+   PC +GG C     V+ +C C   + G  C
Sbjct: 248 ACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC---DHVTGQCHCTAGYMGDRC 301



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 50/173 (28%), Positives = 70/173 (40%), Gaps = 28/173 (16%)

Query: 22  YGAECFPACN-PQNGFCED-DNVCRCQPGWQGPLCDQCVT----SPGCLHGLC------- 68
           +G +C   C+   NG C   D  C+C PGW G  C Q        P C H          
Sbjct: 659 FGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASC 718

Query: 69  -GEPGQCICTDGWDGELCDRDVRAC-------SSAPCANNGTCVSLDDGLYECSCAPGYS 120
             E G C CT GW G  C +   A            C N  +C  +     +C+C  G++
Sbjct: 719 SAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISG---KCTCRTGFT 775

Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIVA 171
           G+ C+++  P    G  CQ    C+++     H +  C C PGF G  C+  A
Sbjct: 776 GQHCEQRCAPGTF-GYGCQQLCECMNNS-TCDHVTGTCYCSPGFKGIRCDQAA 826



 Score = 28.9 bits (63), Expect = 8.1
 Identities = 14/38 (36%), Positives = 17/38 (44%), Gaps = 2/38 (5%)

Query: 21  TYGAECFPACNPQNGFCEDD--NVCRCQPGWQGPLCDQ 56
           T+G  C   C   N    D     C C PG++G  CDQ
Sbjct: 787 TFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQ 824


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  113 bits (282), Expect = 3e-25
 Identities = 60/174 (34%), Positives = 82/174 (47%), Gaps = 10/174 (5%)

Query: 92   CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRA 151
            C+S PC N G C     G Y C C+  Y G  C+    PC  +  PC +GGTCV D G  
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPC--SSKPCLYGGTCVVDNGGF 4074

Query: 152  SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
                C C   ++G  C++ +  C   PC+N G C D      C+C +GF  + C   +  
Sbjct: 4075 V---CQCRGLYTGQRCQL-SPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130

Query: 212  CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLA 265
            C+ +PC +G  C ++T  SY C C  E+ G  C      +P Q    P   GLA
Sbjct: 4131 CSGNPCLHGALC-ENTHGSYHCNCSHEYRGRHC---EDAAPNQYVSTPWNIGLA 4180



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 52/169 (30%), Positives = 75/169 (44%), Gaps = 11/169 (6%)

Query: 47   PGWQGPLCDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANNGT 102
            PG      + C ++P    G+C         C C+  + G  C+  V  CSS PC   GT
Sbjct: 4007 PGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGT 4066

Query: 103  CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGF 162
            CV +D+G + C C   Y+G+ CQ           PC++GGTC D       A C C  GF
Sbjct: 4067 CV-VDNGGFVCQCRGLYTGQRCQLSP---YCKDEPCKNGGTCFDS---LDGAVCQCDSGF 4119

Query: 163  SGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
             G  C+   + C+ NPC +  +C +  G + C C   +  + C     N
Sbjct: 4120 RGERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPN 4168



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 37/122 (30%), Positives = 50/122 (40%), Gaps = 23/122 (18%)

Query: 23   GAECFPACNP-------QNGFCEDDN---VCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG 72
            G  C  + NP         G C  DN   VC+C+  + G    +C  SP C    C   G
Sbjct: 4046 GTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTG---QRCQLSPYCKDEPCKNGG 4102

Query: 73   QCI---------CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKD 123
             C          C  G+ GE C  D+  CS  PC +   C +   G Y C+C+  Y G+ 
Sbjct: 4103 TCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCEN-THGSYHCNCSHEYRGRH 4161

Query: 124  CQ 125
            C+
Sbjct: 4162 CE 4163



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 15/34 (44%), Positives = 18/34 (52%)

Query: 211  NCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
            +CAS+PCQNGG C       Y C C   + G  C
Sbjct: 4016 DCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHC 4049



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 18/46 (39%), Positives = 22/46 (47%), Gaps = 6/46 (13%)

Query: 124  CQKKDGPC--VING---SPCQHGGTCVDDEGRASHASCLCPPGFSG 164
            C  K+G C  V +G    PC  G  CV D     H +C+CP G  G
Sbjct: 3780 CLCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKH-TCVCPSGRFG 3824


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  110 bits (276), Expect = 2e-24
 Identities = 80/247 (32%), Positives = 108/247 (43%), Gaps = 55/247 (22%)

Query: 28  PACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGELCD 86
           P C+ +  F  +   C C+PGW+GP C +      C L G C + GQCIC DG+ GE C 
Sbjct: 159 PFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCID-GQCICDDGFTGEDCS 217

Query: 87  RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC-QHGGTCV 145
           +   AC S  C + G CV   +G+  C C  GY+G DC ++  P      PC +  GTCV
Sbjct: 218 Q--LACPS-DCNDQGKCV---NGV--CICFEGYAGADCSREICPV-----PCSEEHGTCV 264

Query: 146 D------------------------DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCEN 181
           D                        + GR     C+C  GF+G  C   +    PN C +
Sbjct: 265 DGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDC---SELICPNDCFD 321

Query: 182 DGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTG 241
            G C  I G   C C  GF  + C +P    A   C   G C +      +C+C   F G
Sbjct: 322 RGRC--ING--TCYCEEGFTGEDCGKPTCPHA---CHTQGRCEEG-----QCVCDEGFAG 369

Query: 242 LTCVKKR 248
           + C +KR
Sbjct: 370 VDCSEKR 376



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 75/246 (30%), Positives = 100/246 (40%), Gaps = 63/246 (25%)

Query: 28  PACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCL-HGLCGEPGQCICTDGWDGE--- 83
           PA     G C D   C C  G+ G  C +     GC  HG C   GQC+C +G+ GE   
Sbjct: 378 PADCHNRGRCVDGR-CECDDGFTGADCGELKCPNGCSGHGRCVN-GQCVCDEGYTGEDCS 435

Query: 84  -------------------LCDRDVRA--CSSAPCANN----GTCVSLDDGLYECSCAPG 118
                              +C++  +   CS   C N+    G CV+   G+  C C  G
Sbjct: 436 QLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVN---GM--CVCDDG 490

Query: 119 YSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP 178
           Y+G+DC+ +  P       C + G CVD +       C+C  GF+G  C   A    PN 
Sbjct: 491 YTGEDCRDRQCP-----RDCSNRGLCVDGQ-------CVCEDGFTGPDC---AELSCPND 535

Query: 179 CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPE 238
           C   G C +     +C C  GF+ K C      C S  C   G C     V  +C+C   
Sbjct: 536 CHGQGRCVN----GQCVCHEGFMGKDCKEQ--RCPSD-CHGQGRC-----VDGQCICHEG 583

Query: 239 FTGLTC 244
           FTGL C
Sbjct: 584 FTGLDC 589



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 73/247 (29%), Positives = 96/247 (38%), Gaps = 47/247 (19%)

Query: 23  GAECFPACNPQNGFCED---DNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTD 78
           G +C     P + F      +  C C+ G+ G  C +      C   G C E GQC+C +
Sbjct: 307 GEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRC-EEGQCVCDE 365

Query: 79  GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK--------KDGP 130
           G+ G  C    + C  A C N G CV   DG   C C  G++G DC +          G 
Sbjct: 366 GFAGVDCSE--KRCP-ADCHNRGRCV---DG--RCECDDGFTGADCGELKCPNGCSGHGR 417

Query: 131 CVINGSPCQHGGT--------CVDD---EGRASHASCLCPPGFSGNFCEIVANSCTPNPC 179
           CV     C  G T        C +D    GR     C+C  GF G  C  +  SC PN C
Sbjct: 418 CVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDM--SC-PNDC 474

Query: 180 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEF 239
              G C     +  C C  G+  + C           C N G C     V  +C+C+  F
Sbjct: 475 HQHGRCV----NGMCVCDDGYTGEDCR---DRQCPRDCSNRGLC-----VDGQCVCEDGF 522

Query: 240 TGLTCVK 246
           TG  C +
Sbjct: 523 TGPDCAE 529



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 62/190 (32%), Positives = 88/190 (46%), Gaps = 31/190 (16%)

Query: 18  GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCIC 76
           G+      C   C+ Q+G C +  +C C  G+ G  C        C + GLC + GQC+C
Sbjct: 462 GYDCSDMSCPNDCH-QHGRCVN-GMCVCDDGYTGEDCRDRQCPRDCSNRGLCVD-GQCVC 518

Query: 77  TDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGS 136
            DG+ G  C     +C +  C   G CV+      +C C  G+ GKDC+++  P     S
Sbjct: 519 EDGFTGPDCAE--LSCPN-DCHGQGRCVN-----GQCVCHEGFMGKDCKEQRCP-----S 565

Query: 137 PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
            C   G CVD +       C+C  GF+G  C    +SC P+ C N G C  + G  RC C
Sbjct: 566 DCHGQGRCVDGQ-------CICHEGFTGLDCG--QHSC-PSDCNNLGQC--VSG--RCIC 611

Query: 197 PAGFIDKTCS 206
             G+  + CS
Sbjct: 612 NEGYSGEDCS 621



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 52/156 (33%), Positives = 72/156 (46%), Gaps = 26/156 (16%)

Query: 18  GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGL--CGEPGQCI 75
           G      +C   C+   G C D   C C+ G+ GP C + ++ P   HG   C   GQC+
Sbjct: 493 GEDCRDRQCPRDCS-NRGLCVDGQ-CVCEDGFTGPDCAE-LSCPNDCHGQGRCVN-GQCV 548

Query: 76  CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
           C +G+ G+ C    + C S  C   G CV   DG  +C C  G++G DC +   P     
Sbjct: 549 CHEGFMGKDCKE--QRCPS-DCHGQGRCV---DG--QCICHEGFTGLDCGQHSCP----- 595

Query: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
           S C + G CV   GR     C+C  G+SG  C  V+
Sbjct: 596 SDCNNLGQCVS--GR-----CICNEGYSGEDCSEVS 624


>gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
          Length = 2699

 Score =  109 bits (272), Expect = 5e-24
 Identities = 69/229 (30%), Positives = 95/229 (41%), Gaps = 30/229 (13%)

Query: 25  ECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGEL 84
           EC   C+  NG C     C C PG+ GP C +      C        G+C+C  GW G  
Sbjct: 517 ECPRNCHG-NGECVS-GTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574

Query: 85  CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
           CD     C    C   G C+     +  C+C  GY G+ C++ D  C+  G  C + G C
Sbjct: 575 CDVPTTQCIDPQCGGRGICI-----MGSCACNSGYKGESCEEAD--CIDPG--CSNHGVC 625

Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
           +       H  C C PG+ G+ CEI+   C P+ C   G      G   C C   +    
Sbjct: 626 I-------HGECHCSPGWGGSNCEILKTMC-PDQCSGHGTYLQESGS--CTCDPNWTGPD 675

Query: 205 CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
           CS  +    S  C + G C+  T     C C+  +TG  C  +RA  P+
Sbjct: 676 CSNEI---CSVDCGSHGVCMGGT-----CRCEEGWTGPAC-NQRACHPR 715



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 39/201 (19%)

Query: 26  CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGEL 84
           C   C+    + ++   C C P W GP C   + S  C  HG+C   G C C +GW G  
Sbjct: 648 CPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVC-MGGTCRCEEGWTGPA 706

Query: 85  CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP--CQHGG 142
           C++  RAC    CA +GTC    DG  +C C+ G++G+ C        I G P  C   G
Sbjct: 707 CNQ--RACHPR-CAEHGTC---KDG--KCECSQGWNGEHC-------TIEGCPGLCNSNG 751

Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
            C  D+   +   C+C PG+ G  C++   +   +  +N+G               G ID
Sbjct: 752 RCTLDQ---NGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG--------------DGLID 794

Query: 203 KTCSRPVTNCASSPCQNGGTC 223
             C  P   C  S CQN   C
Sbjct: 795 --CMDP-DCCLQSSCQNQPYC 812



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 49/167 (29%), Positives = 69/167 (41%), Gaps = 32/167 (19%)

Query: 97  CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASC 156
           C  NG CVS       C C PG+ G DC +   P + +G+            G+ S   C
Sbjct: 522 CHGNGECVS-----GTCHCFPGFLGPDCSRAACPVLCSGN------------GQYSKGRC 564

Query: 157 LCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
           LC  G+ G  C++    C    C   G+C  I G   C C +G+  ++C     +C    
Sbjct: 565 LCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESCEE--ADCIDPG 618

Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYG 263
           C N G C+       EC C P + G  C   + + P Q     SG+G
Sbjct: 619 CSNHGVCIHG-----ECHCSPGWGGSNCEILKTMCPDQC----SGHG 656



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 45/125 (36%), Positives = 57/125 (45%), Gaps = 23/125 (18%)

Query: 18  GHSTYGAECFPA-CNPQ-------NGFCEDD---------NVCRCQPGWQGPLCDQCVTS 60
           GH TY  E     C+P        N  C  D           CRC+ GW GP C+Q    
Sbjct: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACH 713

Query: 61  PGCL-HGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGY 119
           P C  HG C + G+C C+ GW+GE C   +  C    C +NG C +LD   + C C PG+
Sbjct: 714 PRCAEHGTC-KDGKCECSQGWNGEHC--TIEGCPGL-CNSNGRC-TLDQNGWHCVCQPGW 768

Query: 120 SGKDC 124
            G  C
Sbjct: 769 RGAGC 773



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 30/90 (33%), Positives = 35/90 (38%), Gaps = 22/90 (24%)

Query: 26  CFPACNPQNGFCEDDNV---CRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDG 82
           C   CN  NG C  D     C CQPGW+G  CD  +              + +CTD  D 
Sbjct: 743 CPGLCN-SNGRCTLDQNGWHCVCQPGWRGAGCDVAM--------------ETLCTDSKDN 787

Query: 83  E---LCD-RDVRACSSAPCANNGTCVSLDD 108
           E   L D  D   C  + C N   C  L D
Sbjct: 788 EGDGLIDCMDPDCCLQSSCQNQPYCRGLPD 817


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.467 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,803,524
Number of Sequences: 37866
Number of extensions: 1071901
Number of successful extensions: 8465
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 2378
Number of HSP's gapped (non-prelim): 2208
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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