Guide to the Human Genome
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Search of human proteins with 71852582

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
         (582 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...  1189   0.0  
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...  1182   0.0  
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...  1182   0.0  
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...   564   e-161
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...   327   1e-89
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...   327   1e-89
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...   320   2e-87
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...   237   3e-62
gi|4758010 clock [Homo sapiens]                                       161   2e-39
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]              153   4e-37
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...   137   3e-32
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...   137   3e-32
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]           136   5e-32
gi|21614542 single-minded homolog 1 [Homo sapiens]                    130   4e-30
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]        124   2e-28
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]     124   2e-28
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...   112   1e-24
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...   107   2e-23
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]    107   4e-23
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]    100   5e-21
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]               99   8e-21
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                    94   3e-19
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]    93   6e-19
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]    93   6e-19
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ...    92   1e-18
gi|12707562 period 2 [Homo sapiens]                                    87   3e-17
gi|8567388 period 3 [Homo sapiens]                                     86   9e-17
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]    81   2e-15
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]    81   2e-15
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]    81   2e-15

>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 1189 bits (3076), Expect = 0.0
 Identities = 582/582 (100%), Positives = 582/582 (100%)

Query: 1   MINIESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCN 60
           MINIESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCN
Sbjct: 1   MINIESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCN 60

Query: 61  AMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVG 120
           AMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVG
Sbjct: 61  AMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVG 120

Query: 121 CDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAK 180
           CDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAK
Sbjct: 121 CDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAK 180

Query: 181 TGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHS 240
           TGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHS
Sbjct: 181 TGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHS 240

Query: 241 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRH 300
           TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRH
Sbjct: 241 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRH 300

Query: 301 AIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCY 360
           AIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCY
Sbjct: 301 AIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCY 360

Query: 361 KFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMD 420
           KFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMD
Sbjct: 361 KFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMD 420

Query: 421 SMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNI 480
           SMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNI
Sbjct: 421 SMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNI 480

Query: 481 TSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMI 540
           TSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMI
Sbjct: 481 TSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMI 540

Query: 541 DNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 582
           DNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 541 DNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 582


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 1182 bits (3057), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 5   ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 64
           ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR
Sbjct: 48  ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 107

Query: 65  KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 124
           KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG
Sbjct: 108 KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 167

Query: 125 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 184
           KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP
Sbjct: 168 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 227

Query: 185 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 244
           VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL
Sbjct: 228 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 287

Query: 245 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 304
           KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG
Sbjct: 288 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 347

Query: 305 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 364
           KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI
Sbjct: 348 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 407

Query: 365 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 424
           KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP
Sbjct: 408 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 467

Query: 425 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 484
           SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP
Sbjct: 468 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 527

Query: 485 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 544
           PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ
Sbjct: 528 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 587

Query: 545 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 582
           GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 588 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 1182 bits (3057), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 5   ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 64
           ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR
Sbjct: 48  ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 107

Query: 65  KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 124
           KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG
Sbjct: 108 KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 167

Query: 125 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 184
           KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP
Sbjct: 168 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 227

Query: 185 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 244
           VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL
Sbjct: 228 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 287

Query: 245 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 304
           KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG
Sbjct: 288 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 347

Query: 305 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 364
           KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI
Sbjct: 348 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 407

Query: 365 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 424
           KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP
Sbjct: 408 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 467

Query: 425 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 484
           SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP
Sbjct: 468 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 527

Query: 485 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 544
           PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ
Sbjct: 528 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 587

Query: 545 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 582
           GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 588 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score =  564 bits (1453), Expect = e-161
 Identities = 298/567 (52%), Positives = 392/567 (69%), Gaps = 26/567 (4%)

Query: 17  RLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAV 76
           R+E  EHQ ++K  REAHSQ EKRRRDKMN+ I+EL++++P CN M+RKLDKLTVLRMAV
Sbjct: 95  RVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAV 154

Query: 77  QHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKI 136
           QH+++L+G TN Y  +NY+P+FL D+EL+HLIL+ A+GFLFVVGC+RGKILFVS+SV KI
Sbjct: 155 QHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKI 214

Query: 137 LNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRL 196
           LNY Q  L GQSLFD+LHPKD+AKVKEQLSS D +PRE+LIDAKTGL V +++  G +R+
Sbjct: 215 LNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRV 274

Query: 197 CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDE 256
            SG+RRSFFCR+K  + SVK E    P+  SKKK+ + F TIH TGYL+SWPP  +G++E
Sbjct: 275 YSGSRRSFFCRIKSCKISVKEEHGCLPN--SKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332

Query: 257 DNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAI 316
           +     +  N +CLVAIGRL  ++VPQ  +GEI VK  E+++R A++GKFV+VDQRATAI
Sbjct: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQN-SGEINVKPTEFITRFAVNGKFVYVDQRATAI 391

Query: 317 LAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRW 376
           L YLPQELLGTSCYEYFHQDD  +L + H+ VLQ++EKI T+ YKF+ KDGSF+TL+S+W
Sbjct: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451

Query: 377 FSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPT 436
           FSF NPWTKE+EYIVS NT+VL +  E G+ +F   ++          S E   +++  +
Sbjct: 452 FSFTNPWTKELEYIVSVNTLVLGH-SEPGEASFLPCSSQ---------SSEESSRQSCMS 501

Query: 437 VPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKI 496
           VPG+  GT  GAG IG  IA EI+++ R++ SS     S    +  T   +  S   K++
Sbjct: 502 VPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKEL 561

Query: 497 LNGGTPDIPSS-GLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAA 555
                P  PS  G L    Q            +L +   +  D + +        ND+ A
Sbjct: 562 F----PPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCD--------NDDTA 609

Query: 556 MAVIMSLLEADAGLGGPVDFSDLPWPL 582
           MA  M+ LEA+ GLG P DFSD+ W L
Sbjct: 610 MAAFMNYLEAEGGLGDPGDFSDIQWTL 636


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score =  327 bits (839), Expect = 1e-89
 Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)

Query: 30  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 75  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 134

Query: 90  TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 135 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 194

Query: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 195 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 253

Query: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 260
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+  
Sbjct: 254 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 313

Query: 261 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 320
             +G    CLVAIGRL     P   +     +  E++SRH I+G F FVD R  A + Y 
Sbjct: 314 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 372

Query: 321 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 380
           PQELLG +  E+ H +D   L +  +QV++ + ++ +  ++F+ K+  ++ +R+  F+F 
Sbjct: 373 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 432

Query: 381 NPWTKEVEYIVSTNTVV 397
           NP++ E+EYI+ TNT V
Sbjct: 433 NPYSDEIEYIICTNTNV 449


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score =  327 bits (839), Expect = 1e-89
 Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)

Query: 30  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 90  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149

Query: 90  TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209

Query: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268

Query: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 260
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+  
Sbjct: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 328

Query: 261 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 320
             +G    CLVAIGRL     P   +     +  E++SRH I+G F FVD R  A + Y 
Sbjct: 329 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 387

Query: 321 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 380
           PQELLG +  E+ H +D   L +  +QV++ + ++ +  ++F+ K+  ++ +R+  F+F 
Sbjct: 388 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 447

Query: 381 NPWTKEVEYIVSTNTVV 397
           NP++ E+EYI+ TNT V
Sbjct: 448 NPYSDEIEYIICTNTNV 464


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score =  320 bits (821), Expect = 2e-87
 Identities = 196/537 (36%), Positives = 295/537 (54%), Gaps = 42/537 (7%)

Query: 10  DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 69
           D DD  G       +G  K +RE HS+IE+RRR+KM  +I EL+ +VPTC+A++RK DKL
Sbjct: 51  DFDDEDG-------EGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKL 103

Query: 70  TVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFV 129
           T+LRMAV HMK++RG  N  T+  YKP+FL++ ELKHLIL AADGFLFVV  + G++++V
Sbjct: 104 TILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163

Query: 130 SESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDI 189
           S+SV  +LN  Q++  G +L++ +HP D+ K++EQL +S+ +   R++D KTG  VK + 
Sbjct: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEG 222

Query: 190 TPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK---------KKDRKSFCTIHS 240
                R+C G+RRSF CRM+C    +     +  +T  K         K+    +  +H 
Sbjct: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282

Query: 241 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM--EYVS 298
           TGY+K+WPP  M + E++    +G    CLVAIGRL   V   PV  ++   S+  E++S
Sbjct: 283 TGYIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRL--QVTSSPVCMDMNGMSVPTEFLS 339

Query: 299 RHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN 358
           RH  DG   FVD R  +++ Y PQ+LLG    E+ H +D  HL E  +QV++ + ++ + 
Sbjct: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399

Query: 359 CYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHS 418
            Y+F+ K+  ++ +R+  F+F NP++ E+EYI+ TNT V             QL      
Sbjct: 400 MYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV------------KQLQQQQAE 447

Query: 419 MDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPL 478
           ++     G      +   VP +P G       + +  A+ I    R    +    G S  
Sbjct: 448 LEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEK--ADAIFSQERDPRFAEMFAGISAS 505

Query: 479 NITSTPPPDASSPGGKKILNGGTPDIPS--SG-LLSGQAQENPGYPYSDSSSILGEN 532
                    AS+ G ++I + G+P  PS  SG   S      PG     SSS  G+N
Sbjct: 506 E--KKMMSSASAAGTQQIYSQGSP-FPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQN 559


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score =  237 bits (604), Expect = 3e-62
 Identities = 116/238 (48%), Positives = 164/238 (68%), Gaps = 10/238 (4%)

Query: 30  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 90  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149

Query: 90  TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209

Query: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268

Query: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDN 258
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+
Sbjct: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDD 326



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 21/79 (26%), Positives = 35/79 (44%), Gaps = 11/79 (13%)

Query: 279 HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDI 338
           H++ +  +G + + S E        G+ V+V    T +L     E  G++ Y+  H DD+
Sbjct: 166 HLILEAADGFLFIVSCE-------TGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 218

Query: 339 GHLAECHRQVLQTREKITT 357
             L    R+ L T E   T
Sbjct: 219 DKL----REQLSTSENALT 233


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score =  161 bits (407), Expect = 2e-39
 Identities = 125/394 (31%), Positives = 204/394 (51%), Gaps = 38/394 (9%)

Query: 10  DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 69
           D+DD        E   + K  R + ++ EK+RRD+ N  I EL S++P     +RK+DK 
Sbjct: 15  DRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKS 71

Query: 70  TVLRMAVQHMKTLRGATNPYTEA----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGK 125
           TVL+ ++  ++  +  T     +    ++KPTFLS++E   L+L A DGF   +  D G 
Sbjct: 72  TVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GS 130

Query: 126 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPV 185
           I++VSESV  +L +  +DL+ QS+F+++   + ++V + LS              T L  
Sbjct: 131 IIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILS--------------THLLE 176

Query: 186 KTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLK 245
              +TP    L S  +  F C M   R ++   D   PST    K   +F +++S     
Sbjct: 177 SDSLTP--EYLKSKNQLEFCCHML--RGTI---DPKEPSTYEYVKFIGNFKSLNSVSS-S 228

Query: 246 SWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVK--SMEYVSRHAID 303
           +    +  +   + P  E  +  C VA  RL     PQ +     V+  + E+ SRH+++
Sbjct: 229 AHNGFEGTIQRTHRPSYE--DRVCFVATVRL---ATPQFIKEMCTVEEPNEEFTSRHSLE 283

Query: 304 GKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFK 363
            KF+F+D RA  I+ YLP E+LGTS Y+Y+H DD+ +LA+CH  ++Q   K  +  Y+F 
Sbjct: 284 WKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQ-YGKGKSCYYRFL 342

Query: 364 IKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVV 397
            K   +I L++ ++   + W    E+IV T+TVV
Sbjct: 343 TKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVV 376


>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
          Length = 824

 Score =  153 bits (387), Expect = 4e-37
 Identities = 116/388 (29%), Positives = 199/388 (51%), Gaps = 68/388 (17%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           R + ++ EK+RRD+ N  I EL+S++P     +RK+DK TVL   +  ++      +  T
Sbjct: 11  RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK-HNEVSAQT 66

Query: 91  EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
           E      ++KP+FLS++E   L+L A DGF+  V  D G I++VS+S+  +L +  +D++
Sbjct: 67  EICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLPSDVM 125

Query: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
            Q+L ++L  ++ ++V + LSS                 + TD +P P  L S +   F+
Sbjct: 126 DQNLLNFLPEQEHSEVYKILSSH---------------MLVTD-SPSPEYLKSDSDLEFY 169

Query: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSW----PPTKMGLDEDNEPD 261
           C +        +  K+FP+          +  I   G  +S+     P+  G D      
Sbjct: 170 CHLLRG----SLNPKEFPT----------YEYIKFVGNFRSYNNVPSPSCNGFDNTL--- 212

Query: 262 NEGCNLS-----CLVAIGRLHSH-------VVPQPVNGEIRVKSMEYVSRHAIDGKFVFV 309
           +  C +      C +A  RL +        +V +P+         E+ SRH+++ KF+F+
Sbjct: 213 SRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLE--------EFTSRHSLEWKFLFL 264

Query: 310 DQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSF 369
           D RA  I+ YLP E+LGTS Y+Y+H DD+  LA CH+ ++Q   K  + CY+F  K   +
Sbjct: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323

Query: 370 ITLRSRWFSFMNPWTKEVEYIVSTNTVV 397
           I L++ ++   + W  + E+IV T++VV
Sbjct: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVV 351


>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score =  137 bits (345), Expect = 3e-32
 Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 88
           +E      + RR K +    ELA  +P  + +S  LDK +V+R+ + +++   L  A + 
Sbjct: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78

Query: 89  YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 148
             E + K       ++    L+A DGF+ V+  D G ++++S++V K +  +Q +L G S
Sbjct: 79  DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131

Query: 149 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 208
           +FD+ HP D  +++E L+      R  L+  K G    T             +RSFF RM
Sbjct: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171

Query: 209 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 266
           KC   S +    +  S   K         +H TG++  +         D   +   C   
Sbjct: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213

Query: 267 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323
              ++CLV I       +P P N EI + S  ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269

Query: 324 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 383
           LLG S YEY+H  D  HL + H  +  T+ ++TT  Y+   K G ++ + ++     N  
Sbjct: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328

Query: 384 TKEVEYIVSTNTVV 397
             + + IV  N VV
Sbjct: 329 NSQPQCIVCVNYVV 342


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score =  137 bits (345), Expect = 3e-32
 Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 88
           +E      + RR K +    ELA  +P  + +S  LDK +V+R+ + +++   L  A + 
Sbjct: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78

Query: 89  YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 148
             E + K       ++    L+A DGF+ V+  D G ++++S++V K +  +Q +L G S
Sbjct: 79  DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131

Query: 149 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 208
           +FD+ HP D  +++E L+      R  L+  K G    T             +RSFF RM
Sbjct: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171

Query: 209 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 266
           KC   S +    +  S   K         +H TG++  +         D   +   C   
Sbjct: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213

Query: 267 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323
              ++CLV I       +P P N EI + S  ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269

Query: 324 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 383
           LLG S YEY+H  D  HL + H  +  T+ ++TT  Y+   K G ++ + ++     N  
Sbjct: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328

Query: 384 TKEVEYIVSTNTVV 397
             + + IV  N VV
Sbjct: 329 NSQPQCIVCVNYVV 342


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score =  136 bits (343), Expect = 5e-32
 Identities = 105/384 (27%), Positives = 186/384 (48%), Gaps = 50/384 (13%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           +E      + RR K      ELA  +P  +++S  LDK +++R+A+  ++T +  ++  +
Sbjct: 16  KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75

Query: 91  EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 150
           E   +    +D ++ +L L+A +GF+ VV  D G ++F+SE++ K +  +Q +L G S+F
Sbjct: 76  ENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIF 132

Query: 151 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 210
           D+ HP D  +++E LS                  +K     G         R FF RMKC
Sbjct: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMKC 174

Query: 211 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN---- 266
                 V ++    T + K    ++  +H TG +K +         +  P N  C     
Sbjct: 175 T-----VTNRG--RTVNLKS--ATWKVLHCTGQVKVY--------NNCPPHNSLCGYKEP 217

Query: 267 -LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELL 325
            LSCL+ +     H    P + +I + S  ++SRH++D KF + D R T ++ Y P+ELL
Sbjct: 218 LLSCLIIMCEPIQH----PSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELL 273

Query: 326 GTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTK 385
           G S YE++H  D  ++ + H Q L T+ ++ +  Y+   K G ++ L ++     NP   
Sbjct: 274 GRSAYEFYHALDSENMTKSH-QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNL 332

Query: 386 EVEYIVSTNTVVLANVLEGGDPTF 409
           + + I+  N V+  + +E  D  F
Sbjct: 333 QPQCIMCVNYVL--SEIEKNDVVF 354


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score =  130 bits (326), Expect = 4e-30
 Identities = 110/391 (28%), Positives = 180/391 (46%), Gaps = 48/391 (12%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           +E      + RR+K NS   ELA L+P  +A++ +LDK +++R+   ++K          
Sbjct: 2   KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61

Query: 91  EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
           EA        P      EL   +L+  DGF+FVV  D GKI+++SE+    L  SQ +L 
Sbjct: 62  EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120

Query: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
           G S+++Y+HP D  ++   L++        + + +                     RSFF
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI-------------------ERSFF 161

Query: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 265
            RMKC      +  ++   TC   K       IH +GYLK     +  LD       +GC
Sbjct: 162 LRMKC-----VLAKRNAGLTCGGYK------VIHCSGYLKI---RQYSLDMS---PFDGC 204

Query: 266 NLSC-LVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 324
             +  LVA+G    H +P     EI++ S  ++ R ++D K +F+D R   +  Y PQ+L
Sbjct: 205 YQNVGLVAVG----HSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 260

Query: 325 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 384
           +  + Y + H  D  HL  C   +L  + ++TT  Y+F  K G ++ ++S      N  +
Sbjct: 261 IEKTLYHHVHGCDTFHL-RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRS 319

Query: 385 KEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 415
                IVS N V+     +G   +  Q++AS
Sbjct: 320 SRPHCIVSVNYVLTDTEYKGLQLSLDQISAS 350


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score =  124 bits (311), Expect = 2e-28
 Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           +E      K RR+K N    ELA L+P  +A++ +LDK +++R+   ++K          
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 91  EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
           +A  +P+          EL   +L+  DGF+FVV  D GKI+++SE+    L  SQ +L 
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120

Query: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
           G S+++Y+HP D  ++   L++        L + +                     RSFF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161

Query: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 265
            RMKC      +  ++   TCS  K       IH +GYLK     +  LD       + C
Sbjct: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204

Query: 266 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 324
             +  LVA+G+     +P     EI++ S  ++ R ++D K +F+D R T +  Y PQ+L
Sbjct: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260

Query: 325 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 384
           +  + Y + H  D+ HL   H  +L  + ++TT  Y+   K G ++ ++S      N  +
Sbjct: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319

Query: 385 KEVEYIVSTNTVV 397
                IVS N V+
Sbjct: 320 SRPHCIVSVNYVL 332


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score =  124 bits (311), Expect = 2e-28
 Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           +E      K RR+K N    ELA L+P  +A++ +LDK +++R+   ++K          
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 91  EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
           +A  +P+          EL   +L+  DGF+FVV  D GKI+++SE+    L  SQ +L 
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120

Query: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
           G S+++Y+HP D  ++   L++        L + +                     RSFF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161

Query: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 265
            RMKC      +  ++   TCS  K       IH +GYLK     +  LD       + C
Sbjct: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204

Query: 266 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 324
             +  LVA+G+     +P     EI++ S  ++ R ++D K +F+D R T +  Y PQ+L
Sbjct: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260

Query: 325 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 384
           +  + Y + H  D+ HL   H  +L  + ++TT  Y+   K G ++ ++S      N  +
Sbjct: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319

Query: 385 KEVEYIVSTNTVV 397
                IVS N V+
Sbjct: 320 SRPHCIVSVNYVL 332


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score =  112 bits (279), Expect = 1e-24
 Identities = 87/356 (24%), Positives = 163/356 (45%), Gaps = 47/356 (13%)

Query: 18  LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 77
           +++ +H+   +  +E      + RR +    + +LA  +P    +S  LDK +++R+ + 
Sbjct: 1   MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60

Query: 78  HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 137
           +++  R          +       + L    L+A +GF+ V+  + G + ++SE+V K L
Sbjct: 61  YLRMHRLCA----AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115

Query: 138 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 197
             SQ +LIG S+FD++HP D  ++++ L+   T  R R ++A T                
Sbjct: 116 GLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSR-RKVEAPT---------------- 158

Query: 198 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGL 254
               R F  RMK    S          T + K    ++  ++ +G+++++ P   T    
Sbjct: 159 ---ERCFSLRMKSTLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAG 206

Query: 255 DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRAT 314
             D+EP      L CLV I       +P P + E  +    ++SRH++D KF + D R  
Sbjct: 207 SPDSEPP-----LQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257

Query: 315 AILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 370
            +  Y P +L+G S YEY H  D   +++    +L   + +T   Y+F  + G ++
Sbjct: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 312


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score =  107 bits (268), Expect = 2e-23
 Identities = 86/343 (25%), Positives = 156/343 (45%), Gaps = 47/343 (13%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
           +E      + RR +    + +LA  +P    +S  LDK +++R+ + +++  R       
Sbjct: 16  KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA---- 71

Query: 91  EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 150
              +       + L    L+A +GF+ V+  + G + ++SE+V K L  SQ +LIG S+F
Sbjct: 72  AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 130

Query: 151 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 210
           D++HP D  ++++ L+   T  R R ++A T                    R F  RMK 
Sbjct: 131 DFIHPCDQEELQDALTPQQTLSR-RKVEAPT-------------------ERCFSLRMKS 170

Query: 211 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNL 267
              S          T + K    ++  ++ +G+++++ P   T      D+EP      L
Sbjct: 171 TLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----L 216

Query: 268 SCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGT 327
            CLV I       +P P + E  +    ++SRH++D KF + D R   +  Y P +L+G 
Sbjct: 217 QCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272

Query: 328 SCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 370
           S YEY H  D   +++    +L   + +T   Y+F  + G ++
Sbjct: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 314


>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score =  107 bits (266), Expect = 4e-23
 Identities = 98/381 (25%), Positives = 167/381 (43%), Gaps = 62/381 (16%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 87
           +E      + RR K N    ELA L+P   A++ +LDK +++R+ + ++K +R   N   
Sbjct: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81

Query: 88  -----------PYT-----EANYKPTFLSDDELK-HL---ILRAADGFLFVVGCDRGKIL 127
                      P T     +    P+ L+ +  + HL   IL++ DGF+F +    GK L
Sbjct: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN-QEGKFL 140

Query: 128 FVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLID------AKT 181
           ++SE+V   L  SQ +L G S+FDY+HP D  ++ EQL       R  L        A +
Sbjct: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200

Query: 182 GLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRK 233
                   TP P    S +         RSFF RMK       V  K             
Sbjct: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKS-----------S 249

Query: 234 SFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKS 293
            +  IH TG L+     ++ L       ++   +  LV +    +H +P P   E+R+  
Sbjct: 250 GYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV----AHALPPPTINEVRIDC 298

Query: 294 MEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTRE 353
             +V+R  +D   ++ + R +  +   P +++G  CY + H +D+  +   H  +L  + 
Sbjct: 299 HMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKG 357

Query: 354 KITTNCYKFKIKDGSFITLRS 374
           +  T  Y++  K+G +I ++S
Sbjct: 358 QCVTKYYRWMQKNGGYIWIQS 378


>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
          Length = 920

 Score =  100 bits (248), Expect = 5e-21
 Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 81/400 (20%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 87
           +E      + RR K N    ELA L+P   A++ +LDK +++R+ + ++K +R   N   
Sbjct: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81

Query: 88  ---------PYTEANYKPTFLSDDEL---------------------------KHL---I 108
                    P    + K   +   EL                            HL   I
Sbjct: 82  PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141

Query: 109 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 168
           L++ DGF+F +    GK L++SE+V   L  SQ +L G S+FDY+HP D  ++ EQL   
Sbjct: 142 LQSLDGFVFALN-QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200

Query: 169 DTAPRERLID------AKTGLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPS 214
               R  L        A +        TP P    S +         RSFF RMK     
Sbjct: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260

Query: 215 VKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIG 274
             V  K              +  IH TG L+     ++ L       ++   +  LV + 
Sbjct: 261 RGVHIKS-----------SGYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV- 301

Query: 275 RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFH 334
              +H +P P   E+R+    +V+R  +D   ++ + R +  +   P +++G  CY + H
Sbjct: 302 ---AHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIH 358

Query: 335 QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRS 374
            +D+  +   H  +L  + +  T  Y++  K+G +I ++S
Sbjct: 359 AEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQS 397


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 102/380 (26%), Positives = 167/380 (43%), Gaps = 80/380 (21%)

Query: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--------- 81
           +E      + RR K N    ELA L+P   A+S +LDK +++R++V +++          
Sbjct: 47  KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106

Query: 82  ---LRGATNPYTEANYK---PTFLSDDELKHL---ILRAADGFLFVVGCDRGKILFVSES 132
              LR A  P   A  +      +S+   +HL   IL++ DGF+F +    GK L++SE+
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALN-QEGKFLYISET 165

Query: 133 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLS--------------SSDTAPRERLID 178
           V   L  SQ ++ G S+FDY+HP D ++V EQL               SS ++    L D
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225

Query: 179 AKTGLPVKTDITP-GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKK---KDRKS 234
                 ++  +T   PS L     RSFF RMK              ST +K+        
Sbjct: 226 TP---EIEASLTKVPPSSLVQ--ERSFFVRMK--------------STLTKRGLHVKASG 266

Query: 235 FCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM 294
           +  IH TG L++                   +   LVA+G    H +P     E+ +   
Sbjct: 267 YKVIHVTGRLRA-------------------HALGLVALG----HTLPPAPLAELPLHGH 303

Query: 295 EYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREK 354
             V R ++    +  + R +  +   P EL+G SCY++ H  D   + + H  +L  + +
Sbjct: 304 MIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQ 362

Query: 355 ITTNCYKFKIKDGSFITLRS 374
           + T  Y++  + G F+ L+S
Sbjct: 363 VMTGYYRWLQRAGGFVWLQS 382


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 88/343 (25%), Positives = 157/343 (45%), Gaps = 54/343 (15%)

Query: 35  SQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------- 81
           S   KR RD++N+ +D LASL+P    +  KLDKL+VLR++V +++              
Sbjct: 33  SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92

Query: 82  -LRGATNPYTEANYKPTF-LSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNY 139
              G  +    AN++    L + E    +L+A +GF+ VV  D   + + S ++   L +
Sbjct: 93  ERNGGQDNCRAANFREGLNLQEGE---FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGF 148

Query: 140 SQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLIDAKTGLPVKTDITPGPSR 195
            Q+D+I QS+++ +H +D A+ + Q    L+ S      + I+  TGLP +T +   P +
Sbjct: 149 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLP-QTVVCYNPDQ 207

Query: 196 L----CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTK 251
           +         R F CR++C                    +   F  ++  G LK      
Sbjct: 208 IPPENSPLMERCFICRLRC-----------------LLDNSSGFLAMNFQGKLKY----- 245

Query: 252 MGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQ 311
             L    +   +G  L   +A+  + + + P P   EIR K+  + ++H +D   +  D 
Sbjct: 246 --LHGQKKKGKDGSILPPQLALFAIATPLQP-PSILEIRTKNFIFRTKHKLDFTPIGCDA 302

Query: 312 RATAILAYLPQELLGT-SCYEYFHQDDIGHLAECHRQVLQTRE 353
           +   +L Y   EL    S Y++ H  D+ + AE H ++++T E
Sbjct: 303 KGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGE 345


>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
          Length = 1424

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 133/536 (24%), Positives = 217/536 (40%), Gaps = 90/536 (16%)

Query: 38  EKRRRDKMNSFIDELASLVPT----CNAMSRKLDKLTVLRMAVQHMKTLR--GAT----N 87
           EKRRR++ + +I+ELA L+       +  + K DK  +L+  V+ ++ ++  G T    +
Sbjct: 34  EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93

Query: 88  PYTEANYKPT---FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDL 144
              +A+   T    +  D L  L+L+A DGFLFVV  D G I+FVSE+V + L Y Q DL
Sbjct: 94  DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152

Query: 145 IGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSF 204
           +  S+++ LH +D     + L  S             G+    +     S        +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTV----------NGVSWTNETQRQKS-------HTF 195

Query: 205 FCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEG 264
            CRM    P   +ED +     +  + R+ + T+    +  S P   M   ED +     
Sbjct: 196 NCRMLMKTPHDILEDIN-----ASPEMRQRYETMQC--FALSQPRAMMEEGEDLQ----- 243

Query: 265 CNLSCLVAIG-RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323
              SC++ +  R+ +     P N E       +++RH + GK V +D  +         E
Sbjct: 244 ---SCMICVARRITTGERTFPSNPE------SFITRHDLSGKVVNIDTNSLRSSMRPGFE 294

Query: 324 LLGTSCYEYFH--QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMN 381
            +   C + F    D      + H Q         T  Y+F + DG+ +T +++   F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354

Query: 382 PWTKEVEYIVSTNTV------VLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKR--- 432
           P T +    VST+ +         N    G    P +     S+  M  S   G +    
Sbjct: 355 PVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSS 414

Query: 433 -----THPTVPGIPGGTR-AGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPP 486
                  P+  G   G R  G+  I  +     M+       SPSS  ++   +  + PP
Sbjct: 415 RAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQ-------SPSSYQNNNYGLNMSSPP 467

Query: 487 DAS---SPGGKKIL----NGGTPDI------PSSGLLSGQAQENPGYPYSDSSSIL 529
             S   +P  + I+    N G+P I      P +G+ S  A       +S SSS L
Sbjct: 468 HGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSL 523


>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
          Length = 1420

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 133/536 (24%), Positives = 217/536 (40%), Gaps = 90/536 (16%)

Query: 38  EKRRRDKMNSFIDELASLVPT----CNAMSRKLDKLTVLRMAVQHMKTLR--GAT----N 87
           EKRRR++ + +I+ELA L+       +  + K DK  +L+  V+ ++ ++  G T    +
Sbjct: 34  EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93

Query: 88  PYTEANYKPT---FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDL 144
              +A+   T    +  D L  L+L+A DGFLFVV  D G I+FVSE+V + L Y Q DL
Sbjct: 94  DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152

Query: 145 IGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSF 204
           +  S+++ LH +D     + L  S             G+    +     S        +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTV----------NGVSWTNETQRQKS-------HTF 195

Query: 205 FCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEG 264
            CRM    P   +ED +     +  + R+ + T+    +  S P   M   ED +     
Sbjct: 196 NCRMLMKTPHDILEDIN-----ASPEMRQRYETMQC--FALSQPRAMMEEGEDLQ----- 243

Query: 265 CNLSCLVAIG-RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323
              SC++ +  R+ +     P N E       +++RH + GK V +D  +         E
Sbjct: 244 ---SCMICVARRITTGERTFPSNPE------SFITRHDLSGKVVNIDTNSLRSSMRPGFE 294

Query: 324 LLGTSCYEYFH--QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMN 381
            +   C + F    D      + H Q         T  Y+F + DG+ +T +++   F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354

Query: 382 PWTKEVEYIVSTNTV------VLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKR--- 432
           P T +    VST+ +         N    G    P +     S+  M  S   G +    
Sbjct: 355 PVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSS 414

Query: 433 -----THPTVPGIPGGTR-AGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPP 486
                  P+  G   G R  G+  I  +     M+       SPSS  ++   +  + PP
Sbjct: 415 RAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQ-------SPSSYQNNNYGLNMSSPP 467

Query: 487 DAS---SPGGKKIL----NGGTPDI------PSSGLLSGQAQENPGYPYSDSSSIL 529
             S   +P  + I+    N G+P I      P +G+ S  A       +S SSS L
Sbjct: 468 HGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSL 523


>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
           [Homo sapiens]
          Length = 613

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 43/265 (16%)

Query: 109 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 168
           L+A +GF+ V+  + G + ++SE+V K L  SQ +LIG S+FD++HP D  ++++ L+  
Sbjct: 34  LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQ 92

Query: 169 DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK 228
            T  R R ++A T                    R F  RMK    S          T + 
Sbjct: 93  QTLSR-RKVEAPT-------------------ERCFSLRMKSTLTSRG-------RTLNL 125

Query: 229 KKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPV 285
           K    ++  ++ +G+++++ P   T      D+EP      L CLV I       +P P 
Sbjct: 126 KA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----LQCLVLI----CEAIPHPG 174

Query: 286 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 345
           + E  +    ++SRH++D KF + D R   +  Y P +L+G S YEY H  D   +++  
Sbjct: 175 SLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSI 234

Query: 346 RQVLQTREKITTNCYKFKIKDGSFI 370
             +L   + +T   Y+F  + G ++
Sbjct: 235 HTLLSKGQAVTGQ-YRFLARSGGYL 258


>gi|12707562 period 2 [Homo sapiens]
          Length = 1255

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 76/292 (26%), Positives = 133/292 (45%), Gaps = 46/292 (15%)

Query: 108 ILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSS 167
           I++ AD F   V    GKIL++S+ V  I +  ++        ++L P D+      +  
Sbjct: 186 IVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVG-----VFH 240

Query: 168 SDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCS 227
           S T+P +        LP+ +        +CSGA  SF    +C      +E+K F    S
Sbjct: 241 SFTSPYK--------LPLWS--------MCSGAD-SF--TQEC------MEEKSFFCRVS 275

Query: 228 KKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN--LSCLVAIGRLHSHVVPQPV 285
            +K  ++    H         P +M        D +G    L CL+   R+HS      +
Sbjct: 276 VRKSHENEIRYH---------PFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRI 326

Query: 286 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 345
             E R+    + + H  +  F  VD+RA  +L YLPQ+L+ T      H  D   +   H
Sbjct: 327 PPEKRI----FTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIH 382

Query: 346 RQVLQTR-EKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTV 396
           +++LQ+  +    +  +F+ ++G +ITL + W SF+NPW++++ +I+  + V
Sbjct: 383 KKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKV 434


>gi|8567388 period 3 [Homo sapiens]
          Length = 1201

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 74/288 (25%), Positives = 124/288 (43%), Gaps = 46/288 (15%)

Query: 113 DGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAP 172
           D F+ V     G+++ +SE    ILN  ++ L      D L P+D+              
Sbjct: 131 DTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAHT------- 183

Query: 173 RERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDR 232
                 A+  LP   + T   +R      + FFCR++        ED+         K  
Sbjct: 184 ------ARAQLPFWNNWTQRAARYECAPVKPFFCRIRGG------EDR---------KQE 222

Query: 233 KSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHS-HVVPQ-PVNGEIR 290
           K         YL       +      E ++E C   CL  + ++HS +  P+ PVN  I 
Sbjct: 223 KCHSPFRIIPYL-----IHVHHPAQPELESEPC---CLTVVEKIHSGYEAPRIPVNKRI- 273

Query: 291 VKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ 350
                + + H     F+ VD++A  +L YLPQ+L+GTS   Y H +D   +   H++VL+
Sbjct: 274 -----FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 328

Query: 351 --TREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTV 396
                    +  +F  ++G +I L S W SF+NPW++++ +I+  + V
Sbjct: 329 YAGHPPFEHSPIRFCTQNGDYIILDSSWSSFVNPWSRKISFIIGRHKV 376


>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
          Length = 1399

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)

Query: 35  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 80
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 81  TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 140
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 141 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 199
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190

Query: 200 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237

Query: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 319
                   SCL+ I R      P  + G   V+S  ++++    GK + +D  +      
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285

Query: 320 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 375
              E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343


>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
          Length = 1440

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)

Query: 35  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 80
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 81  TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 140
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 141 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 199
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190

Query: 200 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237

Query: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 319
                   SCL+ I R      P  + G   V+S  ++++    GK + +D  +      
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285

Query: 320 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 375
              E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343


>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
          Length = 1441

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)

Query: 35  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 80
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 81  TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 140
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 141 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 199
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190

Query: 200 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237

Query: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 319
                   SCL+ I R      P  + G   V+S  ++++    GK + +D  +      
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285

Query: 320 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 375
              E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,371,977
Number of Sequences: 37866
Number of extensions: 1350523
Number of successful extensions: 4982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 4670
Number of HSP's gapped (non-prelim): 298
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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