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Search of human proteins with 71852580
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 1274 0.0
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 1274 0.0
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 1182 0.0
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 572 e-163
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 327 2e-89
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 327 2e-89
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 320 2e-87
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 237 3e-62
gi|4758010 clock [Homo sapiens] 161 2e-39
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 153 4e-37
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 137 3e-32
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 137 3e-32
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 136 5e-32
gi|21614542 single-minded homolog 1 [Homo sapiens] 130 5e-30
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 124 3e-28
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 124 3e-28
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 112 1e-24
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 107 3e-23
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 107 4e-23
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 100 5e-21
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 99 9e-21
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 94 4e-19
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 93 6e-19
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 93 6e-19
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 92 1e-18
gi|12707562 period 2 [Homo sapiens] 89 1e-17
gi|8567388 period 3 [Homo sapiens] 86 1e-16
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 81 3e-15
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 81 3e-15
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 81 3e-15
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 1274 bits (3297), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR 60
MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR
Sbjct: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR 60
Query: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ
Sbjct: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
Query: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL
Sbjct: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
Query: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC
Sbjct: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
Query: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED 300
SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED
Sbjct: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED 300
Query: 301 NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL 360
NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL
Sbjct: 301 NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL 360
Query: 361 AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 420
AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF
Sbjct: 361 AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 420
Query: 421 SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV 480
SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV
Sbjct: 421 SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV 480
Query: 481 PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL 540
PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL
Sbjct: 481 PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL 540
Query: 541 NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA 600
NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA
Sbjct: 541 NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA 600
Query: 601 VIMSLLEADAGLGGPVDFSDLPWPL 625
VIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 601 VIMSLLEADAGLGGPVDFSDLPWPL 625
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 1274 bits (3297), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR 60
MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR
Sbjct: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR 60
Query: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ
Sbjct: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
Query: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL
Sbjct: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
Query: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC
Sbjct: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
Query: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED 300
SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED
Sbjct: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDED 300
Query: 301 NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL 360
NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL
Sbjct: 301 NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAIL 360
Query: 361 AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 420
AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF
Sbjct: 361 AYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 420
Query: 421 SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV 480
SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV
Sbjct: 421 SFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTV 480
Query: 481 PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL 540
PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL
Sbjct: 481 PGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKIL 540
Query: 541 NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA 600
NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA
Sbjct: 541 NGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMA 600
Query: 601 VIMSLLEADAGLGGPVDFSDLPWPL 625
VIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 601 VIMSLLEADAGLGGPVDFSDLPWPL 625
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 1182 bits (3057), Expect = 0.0
Identities = 578/578 (100%), Positives = 578/578 (100%)
Query: 48 ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 107
ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR
Sbjct: 5 ESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSR 64
Query: 108 KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 167
KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG
Sbjct: 65 KLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRG 124
Query: 168 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 227
KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP
Sbjct: 125 KILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLP 184
Query: 228 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 287
VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL
Sbjct: 185 VKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYL 244
Query: 288 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 347
KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG
Sbjct: 245 KSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDG 304
Query: 348 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 407
KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI
Sbjct: 305 KFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKI 364
Query: 408 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 467
KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP
Sbjct: 365 KDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLP 424
Query: 468 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 527
SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP
Sbjct: 425 SGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTP 484
Query: 528 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 587
PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ
Sbjct: 485 PPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQ 544
Query: 588 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625
GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Sbjct: 545 GSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 582
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 572 bits (1475), Expect = e-163
Identities = 314/648 (48%), Positives = 420/648 (64%), Gaps = 48/648 (7%)
Query: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQES-MDTDK----- 54
+ ++ I+ +S +SPG S + + RKRKGS +D +S + T+K
Sbjct: 14 LREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKL 73
Query: 55 ----------------DDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASL 98
R+E EHQ ++K REAHSQ EKRRRDKMN+ I+EL+++
Sbjct: 74 SQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAM 133
Query: 99 VPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGF 158
+P CN M+RKLDKLTVLRMAVQH+++L+G TN Y +NY+P+FL D+EL+HLIL+ A+GF
Sbjct: 134 IPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGF 193
Query: 159 LFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRER 218
LFVVGC+RGKILFVS+SV KILNY Q L GQSLFD+LHPKD+AKVKEQLSS D +PRE+
Sbjct: 194 LFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREK 253
Query: 219 LIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSF 278
LIDAKTGL V +++ G +R+ SG+RRSFFCR+K + SVK E P+ SKKK+ + F
Sbjct: 254 LIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPN--SKKKEHRKF 311
Query: 279 CTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME 338
TIH TGYL+SWPP +G++E+ + N +CLVAIGRL ++VPQ +GEI VK E
Sbjct: 312 YTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN-SGEINVKPTE 370
Query: 339 YVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKI 398
+++R A++GKFV+VDQRATAIL YLPQELLGTSCYEYFHQDD +L + H+ VLQ++EKI
Sbjct: 371 FITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKI 430
Query: 399 TTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
T+ YKF+ KDGSF+TL+S+WFSF NPWTKE+EYIVS NT+VL + E G+ +F ++
Sbjct: 431 LTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGH-SEPGEASFLPCSSQ 489
Query: 459 PHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGS 518
S E +++ +VPG+ GT GAG IG IA EI+++ R++ SS S
Sbjct: 490 ---------SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS 540
Query: 519 SPLNITSTPPPDASSPGGKKILNGGTPDIPSS-GLLSGQAQENPGYPYSDSSSILGENPH 577
+ T + S K++ P PS G L Q +L +
Sbjct: 541 PTGLMKDTHTVNCRSMSNKELF----PPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQ 596
Query: 578 IGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625
+ D + + ND+ AMA M+ LEA+ GLG P DFSD+ W L
Sbjct: 597 LDFDALCD--------NDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 636
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 75 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 134
Query: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 135 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 194
Query: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 195 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 253
Query: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 254 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 313
Query: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 314 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 372
Query: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 373 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 432
Query: 424 NPWTKEVEYIVSTNTVV 440
NP++ E+EYI+ TNT V
Sbjct: 433 NPYSDEIEYIICTNTNV 449
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 327 bits (839), Expect = 2e-89
Identities = 166/377 (44%), Positives = 245/377 (64%), Gaps = 11/377 (2%)
Query: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 90 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
Query: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
Query: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
Query: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEP 303
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPE 328
Query: 304 DNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYL 363
+G CLVAIGRL P + + E++SRH I+G F FVD R A + Y
Sbjct: 329 AGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQ 387
Query: 364 PQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFM 423
PQELLG + E+ H +D L + +QV++ + ++ + ++F+ K+ ++ +R+ F+F
Sbjct: 388 PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQ 447
Query: 424 NPWTKEVEYIVSTNTVV 440
NP++ E+EYI+ TNT V
Sbjct: 448 NPYSDEIEYIICTNTNV 464
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 320 bits (821), Expect = 2e-87
Identities = 196/537 (36%), Positives = 295/537 (54%), Gaps = 42/537 (7%)
Query: 53 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 112
D DD G +G K +RE HS+IE+RRR+KM +I EL+ +VPTC+A++RK DKL
Sbjct: 51 DFDDEDG-------EGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKL 103
Query: 113 TVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFV 172
T+LRMAV HMK++RG N T+ YKP+FL++ ELKHLIL AADGFLFVV + G++++V
Sbjct: 104 TILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163
Query: 173 SESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDI 232
S+SV +LN Q++ G +L++ +HP D+ K++EQL +S+ + R++D KTG VK +
Sbjct: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEG 222
Query: 233 TPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK---------KKDRKSFCTIHS 283
R+C G+RRSF CRM+C + + +T K K+ + +H
Sbjct: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
Query: 284 TGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM--EYVS 341
TGY+K+WPP M + E++ +G CLVAIGRL V PV ++ S+ E++S
Sbjct: 283 TGYIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRL--QVTSSPVCMDMNGMSVPTEFLS 339
Query: 342 RHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTN 401
RH DG FVD R +++ Y PQ+LLG E+ H +D HL E +QV++ + ++ +
Sbjct: 340 RHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSV 399
Query: 402 CYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHS 461
Y+F+ K+ ++ +R+ F+F NP++ E+EYI+ TNT V QL
Sbjct: 400 MYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV------------KQLQQQQAE 447
Query: 462 MDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPL 521
++ G + VP +P G + + A+ I R + G S
Sbjct: 448 LEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEK--ADAIFSQERDPRFAEMFAGISAS 505
Query: 522 NITSTPPPDASSPGGKKILNGGTPDIPS--SG-LLSGQAQENPGYPYSDSSSILGEN 575
AS+ G ++I + G+P PS SG S PG SSS G+N
Sbjct: 506 E--KKMMSSASAAGTQQIYSQGSP-FPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQN 559
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 237 bits (604), Expect = 3e-62
Identities = 116/238 (48%), Positives = 164/238 (68%), Gaps = 10/238 (4%)
Query: 73 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132
ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG N
Sbjct: 90 ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
Query: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192
T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV +LN Q++ G +L
Sbjct: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
Query: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252
+D +HP D+ K++EQLS+S+ A R++D KTG VK + R+C G+RRSF CRM+
Sbjct: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
Query: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDN 301
C SV V ++ S K F +H TGY+K+WPP + L +D+
Sbjct: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDD 326
Score = 32.0 bits (71), Expect = 1.8
Identities = 21/79 (26%), Positives = 35/79 (44%), Gaps = 11/79 (13%)
Query: 322 HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDI 381
H++ + +G + + S E G+ V+V T +L E G++ Y+ H DD+
Sbjct: 166 HLILEAADGFLFIVSCE-------TGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 218
Query: 382 GHLAECHRQVLQTREKITT 400
L R+ L T E T
Sbjct: 219 DKL----REQLSTSENALT 233
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 161 bits (407), Expect = 2e-39
Identities = 125/394 (31%), Positives = 204/394 (51%), Gaps = 38/394 (9%)
Query: 53 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 112
D+DD E + K R + ++ EK+RRD+ N I EL S++P +RK+DK
Sbjct: 15 DRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKS 71
Query: 113 TVLRMAVQHMKTLRGATNPYTEA----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGK 168
TVL+ ++ ++ + T + ++KPTFLS++E L+L A DGF + D G
Sbjct: 72 TVLQKSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GS 130
Query: 169 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPV 228
I++VSESV +L + +DL+ QS+F+++ + ++V + LS T L
Sbjct: 131 IIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILS--------------THLLE 176
Query: 229 KTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLK 288
+TP L S + F C M R ++ D PST K +F +++S
Sbjct: 177 SDSLTP--EYLKSKNQLEFCCHML--RGTI---DPKEPSTYEYVKFIGNFKSLNSVSS-S 228
Query: 289 SWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVK--SMEYVSRHAID 346
+ + + + P E + C VA RL PQ + V+ + E+ SRH+++
Sbjct: 229 AHNGFEGTIQRTHRPSYE--DRVCFVATVRL---ATPQFIKEMCTVEEPNEEFTSRHSLE 283
Query: 347 GKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFK 406
KF+F+D RA I+ YLP E+LGTS Y+Y+H DD+ +LA+CH ++Q K + Y+F
Sbjct: 284 WKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQ-YGKGKSCYYRFL 342
Query: 407 IKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVV 440
K +I L++ ++ + W E+IV T+TVV
Sbjct: 343 TKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVV 376
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 153 bits (387), Expect = 4e-37
Identities = 116/388 (29%), Positives = 199/388 (51%), Gaps = 68/388 (17%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
R + ++ EK+RRD+ N I EL+S++P +RK+DK TVL + ++ + T
Sbjct: 11 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK-HNEVSAQT 66
Query: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
E ++KP+FLS++E L+L A DGF+ V D G I++VS+S+ +L + +D++
Sbjct: 67 EICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLPSDVM 125
Query: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Q+L ++L ++ ++V + LSS + TD +P P L S + F+
Sbjct: 126 DQNLLNFLPEQEHSEVYKILSSH---------------MLVTD-SPSPEYLKSDSDLEFY 169
Query: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSW----PPTKMGLDEDNEPD 304
C + + K+FP+ + I G +S+ P+ G D
Sbjct: 170 CHLLRG----SLNPKEFPT----------YEYIKFVGNFRSYNNVPSPSCNGFDNTL--- 212
Query: 305 NEGCNLS-----CLVAIGRLHSH-------VVPQPVNGEIRVKSMEYVSRHAIDGKFVFV 352
+ C + C +A RL + +V +P+ E+ SRH+++ KF+F+
Sbjct: 213 SRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLE--------EFTSRHSLEWKFLFL 264
Query: 353 DQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSF 412
D RA I+ YLP E+LGTS Y+Y+H DD+ LA CH+ ++Q K + CY+F K +
Sbjct: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
Query: 413 ITLRSRWFSFMNPWTKEVEYIVSTNTVV 440
I L++ ++ + W + E+IV T++VV
Sbjct: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVV 351
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 137 bits (345), Expect = 3e-32
Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131
+E + RR K + ELA +P + +S LDK +V+R+ + +++ L A +
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
Query: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191
E + K ++ L+A DGF+ V+ D G ++++S++V K + +Q +L G S
Sbjct: 79 DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
Query: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251
+FD+ HP D +++E L+ R L+ K G T +RSFF RM
Sbjct: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
Query: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309
KC S + + S K +H TG++ + D + C
Sbjct: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
Query: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
++CLV I +P P N EI + S ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
Query: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426
LLG S YEY+H D HL + H + T+ ++TT Y+ K G ++ + ++ N
Sbjct: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
Query: 427 TKEVEYIVSTNTVV 440
+ + IV N VV
Sbjct: 329 NSQPQCIVCVNYVV 342
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 137 bits (345), Expect = 3e-32
Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131
+E + RR K + ELA +P + +S LDK +V+R+ + +++ L A +
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
Query: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191
E + K ++ L+A DGF+ V+ D G ++++S++V K + +Q +L G S
Sbjct: 79 DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
Query: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251
+FD+ HP D +++E L+ R L+ K G T +RSFF RM
Sbjct: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
Query: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309
KC S + + S K +H TG++ + D + C
Sbjct: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
Query: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
++CLV I +P P N EI + S ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
Query: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426
LLG S YEY+H D HL + H + T+ ++TT Y+ K G ++ + ++ N
Sbjct: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
Query: 427 TKEVEYIVSTNTVV 440
+ + IV N VV
Sbjct: 329 NSQPQCIVCVNYVV 342
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 136 bits (343), Expect = 5e-32
Identities = 105/384 (27%), Positives = 186/384 (48%), Gaps = 50/384 (13%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
+E + RR K ELA +P +++S LDK +++R+A+ ++T + ++ +
Sbjct: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
Query: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
E + +D ++ +L L+A +GF+ VV D G ++F+SE++ K + +Q +L G S+F
Sbjct: 76 ENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIF 132
Query: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
D+ HP D +++E LS +K G R FF RMKC
Sbjct: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMKC 174
Query: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN---- 309
V ++ T + K ++ +H TG +K + + P N C
Sbjct: 175 T-----VTNRG--RTVNLKS--ATWKVLHCTGQVKVY--------NNCPPHNSLCGYKEP 217
Query: 310 -LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELL 368
LSCL+ + H P + +I + S ++SRH++D KF + D R T ++ Y P+ELL
Sbjct: 218 LLSCLIIMCEPIQH----PSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELL 273
Query: 369 GTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTK 428
G S YE++H D ++ + H Q L T+ ++ + Y+ K G ++ L ++ NP
Sbjct: 274 GRSAYEFYHALDSENMTKSH-QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNL 332
Query: 429 EVEYIVSTNTVVLANVLEGGDPTF 452
+ + I+ N V+ + +E D F
Sbjct: 333 QPQCIMCVNYVL--SEIEKNDVVF 354
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 130 bits (326), Expect = 5e-30
Identities = 110/391 (28%), Positives = 180/391 (46%), Gaps = 48/391 (12%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
+E + RR+K NS ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
EA P EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
Query: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
G S+++Y+HP D ++ L++ + + + RSFF
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI-------------------ERSFF 161
Query: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
RMKC + ++ TC K IH +GYLK + LD +GC
Sbjct: 162 LRMKC-----VLAKRNAGLTCGGYK------VIHCSGYLKI---RQYSLDMS---PFDGC 204
Query: 309 NLSC-LVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
+ LVA+G H +P EI++ S ++ R ++D K +F+D R + Y PQ+L
Sbjct: 205 YQNVGLVAVG----HSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 260
Query: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
+ + Y + H D HL C +L + ++TT Y+F K G ++ ++S N +
Sbjct: 261 IEKTLYHHVHGCDTFHL-RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRS 319
Query: 428 KEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
IVS N V+ +G + Q++AS
Sbjct: 320 SRPHCIVSVNYVLTDTEYKGLQLSLDQISAS 350
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 124 bits (311), Expect = 3e-28
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
+E K RR+K N ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 134 EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
+A +P+ EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
G S+++Y+HP D ++ L++ L + + RSFF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161
Query: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
RMKC + ++ TCS K IH +GYLK + LD + C
Sbjct: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204
Query: 309 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
+ LVA+G+ +P EI++ S ++ R ++D K +F+D R T + Y PQ+L
Sbjct: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260
Query: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
+ + Y + H D+ HL H +L + ++TT Y+ K G ++ ++S N +
Sbjct: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319
Query: 428 KEVEYIVSTNTVV 440
IVS N V+
Sbjct: 320 SRPHCIVSVNYVL 332
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 124 bits (311), Expect = 3e-28
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
+E K RR+K N ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 134 EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
+A +P+ EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
Query: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
G S+++Y+HP D ++ L++ L + + RSFF
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161
Query: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
RMKC + ++ TCS K IH +GYLK + LD + C
Sbjct: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204
Query: 309 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
+ LVA+G+ +P EI++ S ++ R ++D K +F+D R T + Y PQ+L
Sbjct: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260
Query: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
+ + Y + H D+ HL H +L + ++TT Y+ K G ++ ++S N +
Sbjct: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319
Query: 428 KEVEYIVSTNTVV 440
IVS N V+
Sbjct: 320 SRPHCIVSVNYVL 332
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 112 bits (279), Expect = 1e-24
Identities = 87/356 (24%), Positives = 163/356 (45%), Gaps = 47/356 (13%)
Query: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
+++ +H+ + +E + RR + + +LA +P +S LDK +++R+ +
Sbjct: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
Query: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
+++ R + + L L+A +GF+ V+ + G + ++SE+V K L
Sbjct: 61 YLRMHRLCA----AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
Query: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
SQ +LIG S+FD++HP D ++++ L+ T R R ++A T
Sbjct: 116 GLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSR-RKVEAPT---------------- 158
Query: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGL 297
R F RMK S T + K ++ ++ +G+++++ P T
Sbjct: 159 ---ERCFSLRMKSTLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAG 206
Query: 298 DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRAT 357
D+EP L CLV I +P P + E + ++SRH++D KF + D R
Sbjct: 207 SPDSEPP-----LQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257
Query: 358 AILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
+ Y P +L+G S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 312
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 107 bits (268), Expect = 3e-23
Identities = 86/343 (25%), Positives = 156/343 (45%), Gaps = 47/343 (13%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
+E + RR + + +LA +P +S LDK +++R+ + +++ R
Sbjct: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA---- 71
Query: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
+ + L L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+F
Sbjct: 72 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 130
Query: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
D++HP D ++++ L+ T R R ++A T R F RMK
Sbjct: 131 DFIHPCDQEELQDALTPQQTLSR-RKVEAPT-------------------ERCFSLRMKS 170
Query: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNL 310
S T + K ++ ++ +G+++++ P T D+EP L
Sbjct: 171 TLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----L 216
Query: 311 SCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGT 370
CLV I +P P + E + ++SRH++D KF + D R + Y P +L+G
Sbjct: 217 QCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGC 272
Query: 371 SCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 273 SAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 314
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 107 bits (266), Expect = 4e-23
Identities = 98/381 (25%), Positives = 167/381 (43%), Gaps = 62/381 (16%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130
+E + RR K N ELA L+P A++ +LDK +++R+ + ++K +R N
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
Query: 131 -----------PYT-----EANYKPTFLSDDELK-HL---ILRAADGFLFVVGCDRGKIL 170
P T + P+ L+ + + HL IL++ DGF+F + GK L
Sbjct: 82 PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN-QEGKFL 140
Query: 171 FVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLID------AKT 224
++SE+V L SQ +L G S+FDY+HP D ++ EQL R L A +
Sbjct: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
Query: 225 GLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRK 276
TP P S + RSFF RMK V K
Sbjct: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKS-----------S 249
Query: 277 SFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKS 336
+ IH TG L+ ++ L ++ + LV + +H +P P E+R+
Sbjct: 250 GYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV----AHALPPPTINEVRIDC 298
Query: 337 MEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTRE 396
+V+R +D ++ + R + + P +++G CY + H +D+ + H +L +
Sbjct: 299 HMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKG 357
Query: 397 KITTNCYKFKIKDGSFITLRS 417
+ T Y++ K+G +I ++S
Sbjct: 358 QCVTKYYRWMQKNGGYIWIQS 378
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 100 bits (248), Expect = 5e-21
Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 81/400 (20%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130
+E + RR K N ELA L+P A++ +LDK +++R+ + ++K +R N
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
Query: 131 ---------PYTEANYKPTFLSDDEL---------------------------KHL---I 151
P + K + EL HL I
Sbjct: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
Query: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
L++ DGF+F + GK L++SE+V L SQ +L G S+FDY+HP D ++ EQL
Sbjct: 142 LQSLDGFVFALN-QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
Query: 212 DTAPRERLID------AKTGLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPS 257
R L A + TP P S + RSFF RMK
Sbjct: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
Query: 258 VKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIG 317
V K + IH TG L+ ++ L ++ + LV +
Sbjct: 261 RGVHIKS-----------SGYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV- 301
Query: 318 RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFH 377
+H +P P E+R+ +V+R +D ++ + R + + P +++G CY + H
Sbjct: 302 ---AHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIH 358
Query: 378 QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRS 417
+D+ + H +L + + T Y++ K+G +I ++S
Sbjct: 359 AEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQS 397
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 99.4 bits (246), Expect = 9e-21
Identities = 102/380 (26%), Positives = 167/380 (43%), Gaps = 80/380 (21%)
Query: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--------- 124
+E + RR K N ELA L+P A+S +LDK +++R++V +++
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
Query: 125 ---LRGATNPYTEANYK---PTFLSDDELKHL---ILRAADGFLFVVGCDRGKILFVSES 175
LR A P A + +S+ +HL IL++ DGF+F + GK L++SE+
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALN-QEGKFLYISET 165
Query: 176 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLS--------------SSDTAPRERLID 221
V L SQ ++ G S+FDY+HP D ++V EQL SS ++ L D
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 222 AKTGLPVKTDITP-GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKK---KDRKS 277
++ +T PS L RSFF RMK ST +K+
Sbjct: 226 TP---EIEASLTKVPPSSLVQ--ERSFFVRMK--------------STLTKRGLHVKASG 266
Query: 278 FCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM 337
+ IH TG L++ + LVA+G H +P E+ +
Sbjct: 267 YKVIHVTGRLRA-------------------HALGLVALG----HTLPPAPLAELPLHGH 303
Query: 338 EYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREK 397
V R ++ + + R + + P EL+G SCY++ H D + + H +L + +
Sbjct: 304 MIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQ 362
Query: 398 ITTNCYKFKIKDGSFITLRS 417
+ T Y++ + G F+ L+S
Sbjct: 363 VMTGYYRWLQRAGGFVWLQS 382
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 94.0 bits (232), Expect = 4e-19
Identities = 88/343 (25%), Positives = 157/343 (45%), Gaps = 54/343 (15%)
Query: 78 SQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------- 124
S KR RD++N+ +D LASL+P + KLDKL+VLR++V +++
Sbjct: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
Query: 125 -LRGATNPYTEANYKPTF-LSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNY 182
G + AN++ L + E +L+A +GF+ VV D + + S ++ L +
Sbjct: 93 ERNGGQDNCRAANFREGLNLQEGE---FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGF 148
Query: 183 SQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLIDAKTGLPVKTDITPGPSR 238
Q+D+I QS+++ +H +D A+ + Q L+ S + I+ TGLP +T + P +
Sbjct: 149 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLP-QTVVCYNPDQ 207
Query: 239 L----CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTK 294
+ R F CR++C + F ++ G LK
Sbjct: 208 IPPENSPLMERCFICRLRC-----------------LLDNSSGFLAMNFQGKLKY----- 245
Query: 295 MGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQ 354
L + +G L +A+ + + + P P EIR K+ + ++H +D + D
Sbjct: 246 --LHGQKKKGKDGSILPPQLALFAIATPLQP-PSILEIRTKNFIFRTKHKLDFTPIGCDA 302
Query: 355 RATAILAYLPQELLGT-SCYEYFHQDDIGHLAECHRQVLQTRE 396
+ +L Y EL S Y++ H D+ + AE H ++++T E
Sbjct: 303 KGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGE 345
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 93.2 bits (230), Expect = 6e-19
Identities = 133/536 (24%), Positives = 217/536 (40%), Gaps = 90/536 (16%)
Query: 81 EKRRRDKMNSFIDELASLVPT----CNAMSRKLDKLTVLRMAVQHMKTLR--GAT----N 130
EKRRR++ + +I+ELA L+ + + K DK +L+ V+ ++ ++ G T +
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 131 PYTEANYKPT---FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDL 187
+A+ T + D L L+L+A DGFLFVV D G I+FVSE+V + L Y Q DL
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 188 IGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSF 247
+ S+++ LH +D + L S G+ + S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTV----------NGVSWTNETQRQKS-------HTF 195
Query: 248 FCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEG 307
CRM P +ED + + + R+ + T+ + S P M ED +
Sbjct: 196 NCRMLMKTPHDILEDIN-----ASPEMRQRYETMQC--FALSQPRAMMEEGEDLQ----- 243
Query: 308 CNLSCLVAIG-RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
SC++ + R+ + P N E +++RH + GK V +D + E
Sbjct: 244 ---SCMICVARRITTGERTFPSNPE------SFITRHDLSGKVVNIDTNSLRSSMRPGFE 294
Query: 367 LLGTSCYEYFH--QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMN 424
+ C + F D + H Q T Y+F + DG+ +T +++ F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354
Query: 425 PWTKEVEYIVSTNTV------VLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKR--- 475
P T + VST+ + N G P + S+ M S G +
Sbjct: 355 PVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSS 414
Query: 476 -----THPTVPGIPGGTR-AGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPP 529
P+ G G R G+ I + M+ SPSS ++ + + PP
Sbjct: 415 RAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQ-------SPSSYQNNNYGLNMSSPP 467
Query: 530 DAS---SPGGKKIL----NGGTPDI------PSSGLLSGQAQENPGYPYSDSSSIL 572
S +P + I+ N G+P I P +G+ S A +S SSS L
Sbjct: 468 HGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSL 523
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 93.2 bits (230), Expect = 6e-19
Identities = 133/536 (24%), Positives = 217/536 (40%), Gaps = 90/536 (16%)
Query: 81 EKRRRDKMNSFIDELASLVPT----CNAMSRKLDKLTVLRMAVQHMKTLR--GAT----N 130
EKRRR++ + +I+ELA L+ + + K DK +L+ V+ ++ ++ G T +
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 131 PYTEANYKPT---FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDL 187
+A+ T + D L L+L+A DGFLFVV D G I+FVSE+V + L Y Q DL
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 188 IGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSF 247
+ S+++ LH +D + L S G+ + S +F
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTV----------NGVSWTNETQRQKS-------HTF 195
Query: 248 FCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEG 307
CRM P +ED + + + R+ + T+ + S P M ED +
Sbjct: 196 NCRMLMKTPHDILEDIN-----ASPEMRQRYETMQC--FALSQPRAMMEEGEDLQ----- 243
Query: 308 CNLSCLVAIG-RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
SC++ + R+ + P N E +++RH + GK V +D + E
Sbjct: 244 ---SCMICVARRITTGERTFPSNPE------SFITRHDLSGKVVNIDTNSLRSSMRPGFE 294
Query: 367 LLGTSCYEYFH--QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMN 424
+ C + F D + H Q T Y+F + DG+ +T +++ F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354
Query: 425 PWTKEVEYIVSTNTV------VLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKR--- 475
P T + VST+ + N G P + S+ M S G +
Sbjct: 355 PVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSS 414
Query: 476 -----THPTVPGIPGGTR-AGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPP 529
P+ G G R G+ I + M+ SPSS ++ + + PP
Sbjct: 415 RAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQ-------SPSSYQNNNYGLNMSSPP 467
Query: 530 DAS---SPGGKKIL----NGGTPDI------PSSGLLSGQAQENPGYPYSDSSSIL 572
S +P + I+ N G+P I P +G+ S A +S SSS L
Sbjct: 468 HGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSL 523
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
L+A +GF+ V+ + G + ++SE+V K L SQ +LIG S+FD++HP D ++++ L+
Sbjct: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQ 92
Query: 212 DTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSK 271
T R R ++A T R F RMK S T +
Sbjct: 93 QTLSR-RKVEAPT-------------------ERCFSLRMKSTLTSRG-------RTLNL 125
Query: 272 KKDRKSFCTIHSTGYLKSWPP---TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPV 328
K ++ ++ +G+++++ P T D+EP L CLV I +P P
Sbjct: 126 KA--ATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPP-----LQCLVLI----CEAIPHPG 174
Query: 329 NGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECH 388
+ E + ++SRH++D KF + D R + Y P +L+G S YEY H D +++
Sbjct: 175 SLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSI 234
Query: 389 RQVLQTREKITTNCYKFKIKDGSFI 413
+L + +T Y+F + G ++
Sbjct: 235 HTLLSKGQAVTGQ-YRFLARSGGYL 258
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 89.0 bits (219), Expect = 1e-17
Identities = 96/409 (23%), Positives = 170/409 (41%), Gaps = 70/409 (17%)
Query: 36 NRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNARE--AHSQIEKRRRDKMNSFID 93
N G S+D +DT H+ IK +E H +K+ + K
Sbjct: 91 NPSTSGCSSDQSSKVDT-------------HKELIKTLKELKVHLPADKKAKGK------ 131
Query: 94 ELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILR 153
AS + T R + ++ Q + + G +Y + +H++ +
Sbjct: 132 --ASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIV-K 188
Query: 154 AADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDT 213
AD F V GKIL++S+ V I + ++ ++L P D+ + S T
Sbjct: 189 NADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVG-----VFHSFT 243
Query: 214 APRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKK 273
+P + LP+ + +CSGA SF +C +E+K F S +K
Sbjct: 244 SPYK--------LPLWS--------MCSGAD-SF--TQEC------MEEKSFFCRVSVRK 278
Query: 274 DRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN--LSCLVAIGRLHSHVVPQPVNGE 331
++ H P +M D +G L CL+ R+HS + E
Sbjct: 279 SHENEIRYH---------PFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPE 329
Query: 332 IRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQV 391
R+ + + H + F VD+RA +L YLPQ+L+ T H D + H+++
Sbjct: 330 KRI----FTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKI 385
Query: 392 LQTR-EKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTV 439
LQ+ + + +F+ ++G +ITL + W SF+NPW++++ +I+ + V
Sbjct: 386 LQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKV 434
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 85.9 bits (211), Expect = 1e-16
Identities = 74/288 (25%), Positives = 124/288 (43%), Gaps = 46/288 (15%)
Query: 156 DGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAP 215
D F+ V G+++ +SE ILN ++ L D L P+D+
Sbjct: 131 DTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAHT------- 183
Query: 216 RERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDR 275
A+ LP + T +R + FFCR++ ED+ K
Sbjct: 184 ------ARAQLPFWNNWTQRAARYECAPVKPFFCRIRGG------EDR---------KQE 222
Query: 276 KSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHS-HVVPQ-PVNGEIR 333
K YL + E ++E C CL + ++HS + P+ PVN I
Sbjct: 223 KCHSPFRIIPYL-----IHVHHPAQPELESEPC---CLTVVEKIHSGYEAPRIPVNKRI- 273
Query: 334 VKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ 393
+ + H F+ VD++A +L YLPQ+L+GTS Y H +D + H++VL+
Sbjct: 274 -----FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 328
Query: 394 --TREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTV 439
+ +F ++G +I L S W SF+NPW++++ +I+ + V
Sbjct: 329 YAGHPPFEHSPIRFCTQNGDYIILDSSWSSFVNPWSRKISFIIGRHKV 376
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 81.3 bits (199), Expect = 3e-15
Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)
Query: 78 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Query: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
+F CRM + P D P T + + C + + K + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
Query: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 362
SCL+ I R P + G V+S ++++ GK + +D +
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285
Query: 363 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 81.3 bits (199), Expect = 3e-15
Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)
Query: 78 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Query: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
+F CRM + P D P T + + C + + K + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
Query: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 362
SCL+ I R P + G V+S ++++ GK + +D +
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285
Query: 363 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 81.3 bits (199), Expect = 3e-15
Identities = 89/359 (24%), Positives = 147/359 (40%), Gaps = 62/359 (17%)
Query: 78 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
Query: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Query: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
+F CRM + P D P T + + C + + K + ED E
Sbjct: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
Query: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 362
SCL+ I R P + G V+S ++++ GK + +D +
Sbjct: 238 DFQ-----SCLICIARRLPR--PPAITG---VES--FMTKQDTTGKIISIDTSSLRAAGR 285
Query: 363 LPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 286 TGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,204,212
Number of Sequences: 37866
Number of extensions: 1444333
Number of successful extensions: 5353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 5036
Number of HSP's gapped (non-prelim): 304
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.