Guide to the Human Genome
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Search of human proteins with 62945417

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62945417 dystrophia myotonica-containing WD repeat motif
protein [Homo sapiens]
         (674 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62945417 dystrophia myotonica-containing WD repeat motif prot...  1394   0.0  
gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens]              636   0.0  
gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]              636   0.0  
gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]              517   e-146
gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens]              501   e-142
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    55   2e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            55   2e-07
gi|13376840 WD repeat domain 61 [Homo sapiens]                         54   6e-07
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    52   1e-06
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            52   2e-06
gi|113865883 WD repeat domain 38 [Homo sapiens]                        52   2e-06
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       51   3e-06
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       51   3e-06
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]        51   4e-06
gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]         50   5e-06
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      50   7e-06
gi|39812378 RAN binding protein 9 [Homo sapiens]                       50   7e-06
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     50   7e-06
gi|134142824 forkhead box D2 [Homo sapiens]                            50   9e-06
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 50   9e-06
gi|26665869 WD repeat domain 51B [Homo sapiens]                        50   9e-06
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      49   1e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     49   2e-05
gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo s...    49   2e-05
gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo s...    49   2e-05
gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo s...    49   2e-05
gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo s...    49   2e-05
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    49   2e-05
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    49   2e-05
gi|56549694 enabled homolog isoform a [Homo sapiens]                   49   2e-05

>gi|62945417 dystrophia myotonica-containing WD repeat motif protein
           [Homo sapiens]
          Length = 674

 Score = 1394 bits (3608), Expect = 0.0
 Identities = 674/674 (100%), Positives = 674/674 (100%)

Query: 1   MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQ 60
           MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQ
Sbjct: 1   MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQ 60

Query: 61  PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
           PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG
Sbjct: 61  PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120

Query: 121 SGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI 180
           SGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI
Sbjct: 121 SGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI 180

Query: 181 SLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYL 240
           SLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYL
Sbjct: 181 SLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYL 240

Query: 241 YNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLA 300
           YNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLA
Sbjct: 241 YNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLA 300

Query: 301 CVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRV 360
           CVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRV
Sbjct: 301 CVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRV 360

Query: 361 VARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSP 420
           VARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSP
Sbjct: 361 VARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSP 420

Query: 421 LPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGE 480
           LPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGE
Sbjct: 421 LPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGE 480

Query: 481 PGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEH 540
           PGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEH
Sbjct: 481 PGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEH 540

Query: 541 KRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKK 600
           KRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKK
Sbjct: 541 KRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKK 600

Query: 601 IAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEG 660
           IAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEG
Sbjct: 601 IAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEG 660

Query: 661 ISSQPGNSPSGTVV 674
           ISSQPGNSPSGTVV
Sbjct: 661 ISSQPGNSPSGTVV 674


>gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens]
          Length = 581

 Score =  636 bits (1641), Expect = 0.0
 Identities = 341/621 (54%), Positives = 405/621 (65%), Gaps = 77/621 (12%)

Query: 21  EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80
           EIK+QF TREG YKLLP    +R               P   P  +  S P         
Sbjct: 12  EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47

Query: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140
                        VR+S V L   D +G              GDR+CFN+GRELYFY   
Sbjct: 48  -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76

Query: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200
             +G +++ DL+KPIDKRIYKGTQPTCHDFN  TA  E++SLLVGFSAGQVQ +D IKK+
Sbjct: 77  IYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKE 136

Query: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260
           TSKLFNEERLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C +  P Y LLKQG
Sbjct: 137 TSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 196

Query: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320
           E F+V+  KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G
Sbjct: 197 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 256

Query: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380
            MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT
Sbjct: 257 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 316

Query: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433
           T  EE     G   E SG +E+ +         A  T S      S   +  S+TYRFGS
Sbjct: 317 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 371

Query: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492
            GQDTQ CLWDLTED+L+PH PL+R RT       T P A S+      PG  +P  L R
Sbjct: 372 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 431

Query: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552
           SNSLPH A    AG      +      + +FATL+L +R++R  EK+HKR HS+G+IS  
Sbjct: 432 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 488

Query: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612
                 S        V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL
Sbjct: 489 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 542

Query: 613 EDCIITACQEGLICTWARPGK 633
           EDCI+TACQEG ICTW RPGK
Sbjct: 543 EDCIVTACQEGFICTWGRPGK 563


>gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]
          Length = 569

 Score =  636 bits (1641), Expect = 0.0
 Identities = 341/621 (54%), Positives = 405/621 (65%), Gaps = 77/621 (12%)

Query: 21  EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80
           EIK+QF TREG YKLLP    +R               P   P  +  S P         
Sbjct: 12  EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47

Query: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140
                        VR+S V L   D +G              GDR+CFN+GRELYFY   
Sbjct: 48  -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76

Query: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200
             +G +++ DL+KPIDKRIYKGTQPTCHDFN  TA  E++SLLVGFSAGQVQ +D IKK+
Sbjct: 77  IYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKE 136

Query: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260
           TSKLFNEERLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C +  P Y LLKQG
Sbjct: 137 TSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 196

Query: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320
           E F+V+  KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G
Sbjct: 197 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 256

Query: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380
            MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT
Sbjct: 257 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 316

Query: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433
           T  EE     G   E SG +E+ +         A  T S      S   +  S+TYRFGS
Sbjct: 317 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 371

Query: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492
            GQDTQ CLWDLTED+L+PH PL+R RT       T P A S+      PG  +P  L R
Sbjct: 372 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 431

Query: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552
           SNSLPH A    AG      +      + +FATL+L +R++R  EK+HKR HS+G+IS  
Sbjct: 432 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 488

Query: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612
                 S        V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL
Sbjct: 489 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 542

Query: 613 EDCIITACQEGLICTWARPGK 633
           EDCI+TACQEG ICTW RPGK
Sbjct: 543 EDCIVTACQEGFICTWGRPGK 563


>gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]
          Length = 508

 Score =  517 bits (1331), Expect = e-146
 Identities = 296/621 (47%), Positives = 353/621 (56%), Gaps = 138/621 (22%)

Query: 21  EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80
           EIK+QF TREG YKLLP    +R               P   P  +  S P         
Sbjct: 12  EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47

Query: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140
                        VR+S V L   D +G              GDR+CFN+GRELYFY   
Sbjct: 48  -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76

Query: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200
                             IYKG +                                    
Sbjct: 77  ------------------IYKGVR------------------------------------ 82

Query: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260
                  +RLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C +  P Y LLKQG
Sbjct: 83  -------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 135

Query: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320
           E F+V+  KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G
Sbjct: 136 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 195

Query: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380
            MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT
Sbjct: 196 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 255

Query: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433
           T  EE     G   E SG +E+ +         A  T S      S   +  S+TYRFGS
Sbjct: 256 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 310

Query: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492
            GQDTQ CLWDLTED+L+PH PL+R RT       T P A S+      PG  +P  L R
Sbjct: 311 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 370

Query: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552
           SNSLPH A    AG      +      + +FATL+L +R++R  EK+HKR HS+G+IS  
Sbjct: 371 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 427

Query: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612
                 S        V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL
Sbjct: 428 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 481

Query: 613 EDCIITACQEGLICTWARPGK 633
           EDCI+TACQEG ICTW RPGK
Sbjct: 482 EDCIVTACQEGFICTWGRPGK 502


>gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens]
          Length = 445

 Score =  501 bits (1290), Expect = e-142
 Identities = 254/436 (58%), Positives = 303/436 (69%), Gaps = 22/436 (5%)

Query: 206 NEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQGEGFSV 265
           + ERLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C +  P Y LLKQGE F+V
Sbjct: 18  SHERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAV 77

Query: 266 YAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSY 325
           +  KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G MKSY
Sbjct: 78  HTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSY 137

Query: 326 FGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEE 385
           FGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYTT  EE
Sbjct: 138 FGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEE 197

Query: 386 AATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDT 438
                G   E SG +E+ +         A  T S      S   +  S+TYRFGS GQDT
Sbjct: 198 -----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDT 252

Query: 439 QFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSRSNSLP 497
           Q CLWDLTED+L+PH PL+R RT       T P A S+      PG  +P  L RSNSLP
Sbjct: 253 QLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLP 312

Query: 498 HPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGS 557
           H A    AG      +      + +FATL+L +R++R  EK+HKR HS+G+IS       
Sbjct: 313 HSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS------- 364

Query: 558 GSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCII 617
            S        V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FLEDCI+
Sbjct: 365 -SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIV 423

Query: 618 TACQEGLICTWARPGK 633
           TACQEG ICTW RPGK
Sbjct: 424 TACQEGFICTWGRPGK 439


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 45/129 (34%), Positives = 53/129 (41%), Gaps = 18/129 (13%)

Query: 3   AGGAEGGSGPGA----AMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQP 58
           AG A  G+GP A    A G   E     R R       PG G  +R GP S + P+ P  
Sbjct: 68  AGAA--GAGPAAPAEGAPGAAPEPPPAGRAR-------PGGGGPQRPGPPSPRRPLVPAG 118

Query: 59  PQPP-----PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
           P PP     P P  ++G  A  PA++   AGP P PA PA       L      G G  P
Sbjct: 119 PAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGP 178

Query: 114 ATPAGLGSG 122
               G G G
Sbjct: 179 GPGPGPGPG 187



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 27/62 (43%), Positives = 30/62 (48%), Gaps = 5/62 (8%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGA----AGPASSPPPA-GPGPGPAL 91
           P +G+A    P  A   V   P   P GPA  +GP A    AGP   P P  GPGPGP  
Sbjct: 129 PPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGK 188

Query: 92  PA 93
           PA
Sbjct: 189 PA 190



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 38/115 (33%), Positives = 44/115 (38%), Gaps = 15/115 (13%)

Query: 10  SGPGAAM---GDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPP----QPP 62
           +GPGAA    G  A + S          +  G  A       +A   V   PP      P
Sbjct: 190 AGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAP 249

Query: 63  PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPA 117
           P PA+ S P A  PA+  P A P P P  PA       L  P    AG P A PA
Sbjct: 250 PAPAAPSPPAAPAPAA--PAAAPPPPPPAPAT------LARPPGHPAGPPTAAPA 296



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 42/154 (27%), Positives = 53/154 (34%), Gaps = 24/154 (15%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQP-----PPGPASASGPGAAGPASSPPPAGPGPGPAL 91
           P  GAA    PA+   P  P P  P     PP PA A+     G  + PP A P   P  
Sbjct: 242 PFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPA 301

Query: 92  PAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDL 151
            A            SAGA   PA  AG  +G   V    G      PG         +  
Sbjct: 302 AA--------QNGGSAGAAPAPAPAAGGPAG---VSGQPG------PGAAAAAPAPGVKA 344

Query: 152 NKPIDKRIYKGTQPTCHDFNQFTAATETISLLVG 185
             P  KR+ +   P          A+   S+++G
Sbjct: 345 ESP--KRVVQAAPPAAQTLAASGPASTAASMVIG 376



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 42/127 (33%), Positives = 48/127 (37%), Gaps = 29/127 (22%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAAR------RSGPASAQTPVP-PQ 57
           G   G GPG   G  A      +T  G   LL    AA        +GPA A  P+P P 
Sbjct: 179 GPGPGPGPGKPAGPGAA-----QTLNGSAALLNSHHAAAPAVSLVNNGPA-ALLPLPKPA 232

Query: 58  PP----QPPP--GPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGE 111
            P    Q PP  G A+   P A  P ++P PA P   P  P           P  A    
Sbjct: 233 APGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPP----------PAPATLAR 282

Query: 112 PPATPAG 118
           PP  PAG
Sbjct: 283 PPGHPAG 289



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 46/150 (30%), Positives = 52/150 (34%), Gaps = 28/150 (18%)

Query: 383 AEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCL 442
           A  AA A GA G        E P A      GG P  P P   S       AG       
Sbjct: 73  AGPAAPAEGAPGAAP-----EPPPAGRARPGGGGPQRPGPP--SPRRPLVPAG------- 118

Query: 443 WDLTEDVLYPHPPLARTRTLP----GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPH 498
                    P PP A+ R  P    G+    P AA+ + G EP P   P   +   +L  
Sbjct: 119 ---------PAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAG-PAKPAGPAALAA 168

Query: 499 PAGGGKAGGPGVAAEPGTPFSIGRFATLTL 528
            AG G   GPG    PG     G  A  TL
Sbjct: 169 RAGPGPGPGPGPGPGPGPGKPAGPGAAQTL 198



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 28/69 (40%), Positives = 31/69 (44%), Gaps = 15/69 (21%)

Query: 65  PASASGPGAAGPAS-------SPPPAG---PGPG----PALPAVRLSLVRLG-EPDSAGA 109
           PA A+G G A PA         PPPAG   PG G    P  P+ R  LV  G  P +A  
Sbjct: 67  PAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKL 126

Query: 110 GEPPATPAG 118
             PP   AG
Sbjct: 127 RPPPEGSAG 135



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 37/124 (29%), Positives = 43/124 (34%), Gaps = 24/124 (19%)

Query: 414 GGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAA 473
           G A L PLPK  +     G+  Q   F           P PP A     P      PP A
Sbjct: 221 GPAALLPLPKPAAP----GTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPA 276

Query: 474 SSSRGGEPG--PGP------LPRSLSRSNS-------LPHPAGGGKAG-----GPGVAAE 513
            ++    PG   GP      +P   +  N         P PA GG AG     GPG AA 
Sbjct: 277 PATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAA 336

Query: 514 PGTP 517
              P
Sbjct: 337 APAP 340



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 23/74 (31%), Positives = 26/74 (35%), Gaps = 12/74 (16%)

Query: 452 PHPPLARTRTLP---------GTPGTTPPAASS---SRGGEPGPGPLPRSLSRSNSLPHP 499
           P PP   T   P           P   PPAA+    S G  P P P     +  +  P P
Sbjct: 272 PPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGP 331

Query: 500 AGGGKAGGPGVAAE 513
                A  PGV AE
Sbjct: 332 GAAAAAPAPGVKAE 345



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 38/128 (29%), Positives = 46/128 (35%), Gaps = 35/128 (27%)

Query: 4   GGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPP 63
           G A     P  A G  A +  Q           PG GAA  +     +   P +  Q  P
Sbjct: 307 GSAGAAPAPAPAAGGPAGVSGQ-----------PGPGAAAAAPAPGVKAESPKRVVQAAP 355

Query: 64  ---------GPASAS-----GPGAAG----PASSPPPAGPGPGPALP-----AVRLSLVR 100
                    GPAS +     GP   G    PA+ PPPA PG    LP     AV  SL R
Sbjct: 356 PAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPA-PGTPTGLPKGAAGAVTQSLSR 414

Query: 101 LGEPDSAG 108
                ++G
Sbjct: 415 TPTATTSG 422


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 28/95 (29%), Positives = 49/95 (51%), Gaps = 1/95 (1%)

Query: 291 AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLV 350
           AFSP G++LA  S D  +R +   +       K +   +L + WSPDGR + +G ++  +
Sbjct: 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180

Query: 351 TVWSFTEGRVVARG-HGHKSWVNAVAFDPYTTRAE 384
            +W  + G+ V R   GH  W+  ++++P     E
Sbjct: 181 LLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 28/123 (22%), Positives = 55/123 (44%)

Query: 256 LLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDS 315
           L+   + F+++       + PL +    +  +N+  FSPD R +A  S D  ++++   +
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403

Query: 316 MLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVA 375
                 ++ +   +  + WS D R +V+G  D  + VW     ++     GH   V AV 
Sbjct: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVD 463

Query: 376 FDP 378
           + P
Sbjct: 464 WSP 466



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 42/176 (23%), Positives = 70/176 (39%), Gaps = 18/176 (10%)

Query: 278 AKWAVGEG--PLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWS 335
           +KW  G    PL+    +P+ R++A  S+DG +R++   +     ++  +   + C+ W 
Sbjct: 199 SKWITGLSWEPLHA---NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG 255

Query: 336 PDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFD---PYTTRAEEAATAAGA 392
            DG  + +  +D  + VW   +G +     GH  WVN +A        T A E A A+  
Sbjct: 256 GDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVN 314

Query: 393 DGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTED 448
             +  G  +E +  A    +            G    R  S   D    LW   ED
Sbjct: 315 PQDLQGSLQELKERALSRYNL---------VRGQGPERLVSGSDDFTLFLWSPAED 361



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 21/65 (32%), Positives = 34/65 (52%)

Query: 289 EFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDD 348
           + A+S D R L   S D  L+V+   +  L   +  +   +  V WSPDG+ V +GG+D 
Sbjct: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478

Query: 349 LVTVW 353
            + +W
Sbjct: 479 CLRIW 483



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 14/57 (24%), Positives = 29/57 (50%)

Query: 322 MKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
           ++ +   ++ V +SP G+Y+ +G  D  V  W  +         GH+ WV ++++ P
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 10/92 (10%)

Query: 291 AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGG---LLCVCW-----SPDGRYVV 342
           ++SPDGR LA   ++G  ++  +D    + + ++  G    +  + W     +P+ RYV 
Sbjct: 163 SWSPDGRKLASGCKNG--QILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220

Query: 343 TGGEDDLVTVWSFTEGRVVARGHGHKSWVNAV 374
           +  +D  V +W  T GR      GH   V  +
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCL 252


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 27/91 (29%), Positives = 47/91 (51%)

Query: 291 AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLV 350
           A+SPDG++LA  + DG + +F   +  L   ++ +   +  + +SPD + +VT  +D  +
Sbjct: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214

Query: 351 TVWSFTEGRVVARGHGHKSWVNAVAFDPYTT 381
            ++      +     GH SWV  VAF P  T
Sbjct: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 25/100 (25%), Positives = 54/100 (54%), Gaps = 2/100 (2%)

Query: 281 AVGEGPLNEF--AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDG 338
           ++  GP++ +  AFSPD ++LA  +  G + +F  +S      + +    +L + +SPDG
Sbjct: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160

Query: 339 RYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
           +Y+ +G  D ++ ++    G+++    GH   + ++ F P
Sbjct: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 24/92 (26%), Positives = 39/92 (42%)

Query: 286 PLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGG 345
           P+    FSPD + L   S DG ++++      L G +  +   +L V + PD  + V+  
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSS 251

Query: 346 EDDLVTVWSFTEGRVVARGHGHKSWVNAVAFD 377
            D  V VW       V     H+  V  V ++
Sbjct: 252 SDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN 283


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 78/347 (22%), Positives = 116/347 (33%), Gaps = 74/347 (21%)

Query: 88  GPALPAVRLSLVR----LGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPG---- 139
           GP LP V +   R    LG     GAG+  ATP  L   G   C +L   +    G    
Sbjct: 9   GPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGE 68

Query: 140 --CCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLI 197
             CC+     S   +   D+ I          +N +    +  + L G S G V  L   
Sbjct: 69  VYCCKFHPNGSTLASAGFDRLILL--------WNVY-GDCDNYATLKGHS-GAVMELHY- 117

Query: 198 KKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLL 257
             D S LF+     DKT   +     +SE+        GH    N  +P    P      
Sbjct: 118 NTDGSMLFSAST--DKTVAVW-----DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170

Query: 258 KQGEGFSVYAAKSKAP---------------------------RNPLAKWAVGEGPLNE- 289
                  ++  + KA                             N +  W + +  L   
Sbjct: 171 SDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT 230

Query: 290 ----------FAFSPDGRHLACVSQDGCLRVFHFDSM--------LLRGLMKSYFGGLLC 331
                      + S +G +L   + D  +RV+             + +G + ++   LL 
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290

Query: 332 VCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
             WSPDG  +  G  D  V VW  T  R++ +  GH   +N VAF P
Sbjct: 291 CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 5/111 (4%)

Query: 284 EGPLNEFAFSPDGRHLACVSQDGCLRVFH-FDSMLLRGLMKSYFGGLLCVCWSPDGRYVV 342
           EG +    F P+G  LA    D  + +++ +        +K + G ++ + ++ DG  + 
Sbjct: 66  EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125

Query: 343 TGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGAD 393
           +   D  V VW    G  V R  GH S+VN+     Y  R        G+D
Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSC----YPARRGPQLVCTGSD 172


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 28/123 (22%), Positives = 55/123 (44%)

Query: 256 LLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDS 315
           L+   + F+++       + PL +    +  +N+  FSPD R +A  S D  ++++   +
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111

Query: 316 MLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVA 375
                 ++ +   +  + WS D R +V+G  D  + VW     ++     GH   V AV 
Sbjct: 112 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVD 171

Query: 376 FDP 378
           + P
Sbjct: 172 WSP 174



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 21/65 (32%), Positives = 34/65 (52%)

Query: 289 EFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDD 348
           + A+S D R L   S D  L+V+   +  L   +  +   +  V WSPDG+ V +GG+D 
Sbjct: 127 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 186

Query: 349 LVTVW 353
            + +W
Sbjct: 187 CLRIW 191


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 5/133 (3%)

Query: 248 ASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVG--EGPLNEFAFSPDGRHLACVSQD 305
           A +P    LL   E   VY  ++++ +     W +G   GP+    FSPDG   A  S D
Sbjct: 28  AFSPDGQMLLTGSEDGCVYGWETRSGQ---LLWRLGGHTGPVKFCRFSPDGHLFASASCD 84

Query: 306 GCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGH 365
             +R++         ++K +   +  V +SPD R + +GG D  V +W    G+++    
Sbjct: 85  CTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLV 144

Query: 366 GHKSWVNAVAFDP 378
           GH+  + +  F P
Sbjct: 145 GHRDSIQSSDFSP 157



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 29/94 (30%), Positives = 44/94 (46%)

Query: 285 GPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTG 344
           G +N  AFSPDG+ L   S+DGC+  +   S  L   +  + G +    +SPDG    + 
Sbjct: 22  GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81

Query: 345 GEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
             D  V +W     + +    GH+  V  V+F P
Sbjct: 82  SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP 115



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 22/90 (24%), Positives = 43/90 (47%), Gaps = 4/90 (4%)

Query: 292 FSPDGRHLACVSQDGCLRVFHFDSM---LLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDD 348
           FSP    LA  S D  + ++    +   +    ++ +   + C+C+S  G  + +G  D 
Sbjct: 155 FSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDK 213

Query: 349 LVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
            + +W  T   ++ +  GH +WV ++AF P
Sbjct: 214 TIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 20/131 (15%)

Query: 10  SGPGAAMGDC-AEIKSQFRTREGFYKLL---PGDGAARRSGPASAQTPVPPQPPQ----- 60
           S PG   GD   E +    +  G Y  L   PG  A  R+ P+   TP    P       
Sbjct: 720 SRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFAL 779

Query: 61  -------PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
                  PPP P   S    +GP+  PPP    PGP   A       L EP  AG  EPP
Sbjct: 780 RARRKGPPPPPPKRLSS--VSGPSPEPPPLDESPGPKEGATGPRRRTLSEP--AGPSEPP 835

Query: 114 ATPAGLGSGGD 124
             PA  G   D
Sbjct: 836 GPPAPAGPASD 846



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 36/100 (36%), Positives = 40/100 (40%), Gaps = 23/100 (23%)

Query: 42  ARRSGP--------ASAQTPVPPQPP-QPPPGPASASGPGAAGP--ASSPPPAGPG--PG 88
           ARR GP        +S   P P  PP    PGP      GA GP   +   PAGP   PG
Sbjct: 781 ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKE----GATGPRRRTLSEPAGPSEPPG 836

Query: 89  PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCF 128
           P  PA   S     EP       P  TP   GS G+ + F
Sbjct: 837 PPAPAGPASDTEEEEPG------PEGTPPSRGSSGEGLPF 870



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 28/105 (26%), Positives = 34/105 (32%), Gaps = 3/105 (2%)

Query: 18   DCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPA 77
            D  + + + R RE     L   G A  +   +A  P P     PP        P +    
Sbjct: 906  DTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQ 965

Query: 78   SSPPPAGPGPG---PALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
              P P  P P    P  P     L         G  EPPA PA L
Sbjct: 966  GVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL 1010



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 32/119 (26%), Positives = 40/119 (33%), Gaps = 15/119 (12%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
           P PP  R  ++ G     PP   S    E   GP  R+LS       P G     GP   
Sbjct: 787 PPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASD 846

Query: 512 AEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPR 570
            E   P   G            RG+  E   +   GN++            KP+GP PR
Sbjct: 847 TEEEEPGPEG--------TPPSRGSSGEGLPFAEEGNLTI-------KQRPKPAGPPPR 890



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 11/90 (12%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGA------AGPASSPPPAGPGPGPA 90
           P +GA   +GP   +T   P  P  PPGP + +GP +       GP  +PP  G   G  
Sbjct: 813 PKEGA---TGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRG-SSGEG 867

Query: 91  LPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
           LP      + + +        P  TP   G
Sbjct: 868 LPFAEEGNLTIKQRPKPAGPPPRETPVPPG 897



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 2/83 (2%)

Query: 450 LYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPG 509
           ++ +P  + +   PG P   P A S   G    P   PR   RS+SL  P  G   G   
Sbjct: 673 VFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP--GPTEGDAE 730

Query: 510 VAAEPGTPFSIGRFATLTLQERR 532
             AE     ++G +ATLT +  R
Sbjct: 731 GEAEGPVGSTLGSYATLTRRPGR 753



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 40/144 (27%), Positives = 54/144 (37%), Gaps = 26/144 (18%)

Query: 397 SGEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYR-----FGSAGQDTQF---CLWDLT 446
           + + EEEEP   GT  + G+    LP A  G++T +      G   ++T       ++LT
Sbjct: 844 ASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLT 903

Query: 447 EDVLYPHPPLARTR-----------TLPGTPGTTPPAASSSRGGEPG----PGPLPRSLS 491
           E       P  R R               TPG   P  S + G  P     P P P SL 
Sbjct: 904 ESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLP 963

Query: 492 RSNSLPHPAGGGKAGGPGVAAEPG 515
            +  +P P     A  P V   PG
Sbjct: 964 -AQGVPTPLAPSPAMQPPVPPCPG 986



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 29/102 (28%), Positives = 36/102 (35%), Gaps = 19/102 (18%)

Query: 36   LPGDGAARRSGPASA-QTPVPPQPPQPPPGPASASGPGAAGPASSPPPAG-------PGP 87
            LP  G      P+ A Q PVPP      PGP   S   +     + PPA        PG 
Sbjct: 962  LPAQGVPTPLAPSPAMQPPVPP-----CPGPGLESSAASRWNGETEPPAAPAALLKVPGA 1016

Query: 88   GPALPAVRLSLVRLG------EPDSAGAGEPPATPAGLGSGG 123
            G A   V ++  +L        P       PP  P   G+ G
Sbjct: 1017 GTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1058


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 20/131 (15%)

Query: 10  SGPGAAMGDC-AEIKSQFRTREGFYKLL---PGDGAARRSGPASAQTPVPPQPPQ----- 60
           S PG   GD   E +    +  G Y  L   PG  A  R+ P+   TP    P       
Sbjct: 802 SRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFAL 861

Query: 61  -------PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
                  PPP P   S    +GP+  PPP    PGP   A       L EP  AG  EPP
Sbjct: 862 RARRKGPPPPPPKRLSS--VSGPSPEPPPLDESPGPKEGATGPRRRTLSEP--AGPSEPP 917

Query: 114 ATPAGLGSGGD 124
             PA  G   D
Sbjct: 918 GPPAPAGPASD 928



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 36/100 (36%), Positives = 40/100 (40%), Gaps = 23/100 (23%)

Query: 42  ARRSGP--------ASAQTPVPPQPP-QPPPGPASASGPGAAGP--ASSPPPAGPG--PG 88
           ARR GP        +S   P P  PP    PGP      GA GP   +   PAGP   PG
Sbjct: 863 ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKE----GATGPRRRTLSEPAGPSEPPG 918

Query: 89  PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCF 128
           P  PA   S     EP       P  TP   GS G+ + F
Sbjct: 919 PPAPAGPASDTEEEEPG------PEGTPPSRGSSGEGLPF 952



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 28/105 (26%), Positives = 34/105 (32%), Gaps = 3/105 (2%)

Query: 18   DCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPA 77
            D  + + + R RE     L   G A  +   +A  P P     PP        P +    
Sbjct: 988  DTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQ 1047

Query: 78   SSPPPAGPGPG---PALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
              P P  P P    P  P     L         G  EPPA PA L
Sbjct: 1048 GVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL 1092



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 32/119 (26%), Positives = 40/119 (33%), Gaps = 15/119 (12%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
           P PP  R  ++ G     PP   S    E   GP  R+LS       P G     GP   
Sbjct: 869 PPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASD 928

Query: 512 AEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPR 570
            E   P   G            RG+  E   +   GN++            KP+GP PR
Sbjct: 929 TEEEEPGPEG--------TPPSRGSSGEGLPFAEEGNLTI-------KQRPKPAGPPPR 972



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 11/90 (12%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGA------AGPASSPPPAGPGPGPA 90
           P +GA   +GP   +T   P  P  PPGP + +GP +       GP  +PP  G   G  
Sbjct: 895 PKEGA---TGPRR-RTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRG-SSGEG 949

Query: 91  LPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
           LP      + + +        P  TP   G
Sbjct: 950 LPFAEEGNLTIKQRPKPAGPPPRETPVPPG 979



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 2/83 (2%)

Query: 450 LYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPG 509
           ++ +P  + +   PG P   P A S   G    P   PR   RS+SL  P  G   G   
Sbjct: 755 VFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP--GPTEGDAE 812

Query: 510 VAAEPGTPFSIGRFATLTLQERR 532
             AE     ++G +ATLT +  R
Sbjct: 813 GEAEGPVGSTLGSYATLTRRPGR 835



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 40/144 (27%), Positives = 54/144 (37%), Gaps = 26/144 (18%)

Query: 397  SGEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYR-----FGSAGQDTQF---CLWDLT 446
            + + EEEEP   GT  + G+    LP A  G++T +      G   ++T       ++LT
Sbjct: 926  ASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLT 985

Query: 447  EDVLYPHPPLARTR-----------TLPGTPGTTPPAASSSRGGEPG----PGPLPRSLS 491
            E       P  R R               TPG   P  S + G  P     P P P SL 
Sbjct: 986  ESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLP 1045

Query: 492  RSNSLPHPAGGGKAGGPGVAAEPG 515
             +  +P P     A  P V   PG
Sbjct: 1046 -AQGVPTPLAPSPAMQPPVPPCPG 1068



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 29/102 (28%), Positives = 36/102 (35%), Gaps = 19/102 (18%)

Query: 36   LPGDGAARRSGPASA-QTPVPPQPPQPPPGPASASGPGAAGPASSPPPAG-------PGP 87
            LP  G      P+ A Q PVPP      PGP   S   +     + PPA        PG 
Sbjct: 1044 LPAQGVPTPLAPSPAMQPPVPP-----CPGPGLESSAASRWNGETEPPAAPAALLKVPGA 1098

Query: 88   GPALPAVRLSLVRLG------EPDSAGAGEPPATPAGLGSGG 123
            G A   V ++  +L        P       PP  P   G+ G
Sbjct: 1099 GTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1140


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 35/102 (34%), Positives = 39/102 (38%), Gaps = 16/102 (15%)

Query: 38  GDGAARRSGPASAQTPVPPQPPQPPPG------PASASGPGAAGPASSPPPAGPGPG--- 88
           G  A    GP     P PP  P PPPG      PA+A G G   P + P PA  GPG   
Sbjct: 161 GPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGG 220

Query: 89  -------PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
                   A+   +L  V   E  S G   P A     G GG
Sbjct: 221 AGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGG 262



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 35/105 (33%), Positives = 40/105 (38%), Gaps = 25/105 (23%)

Query: 21  EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80
           E++ Q R + G     P +   RR   A      P   P PPPGP               
Sbjct: 137 EVEQQKRQQPG-----PSEHIERRVSNAGGPPAPPAGGPPPPPGPP-------------- 177

Query: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPA--TPAGLGSGG 123
           PP GP P P LP   +     G    AG G PPA   PA  G GG
Sbjct: 178 PPPGPPPPPGLPPSGVPAAAHG----AGGGPPPAPPLPAAQGPGG 218



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 25/63 (39%), Positives = 28/63 (44%), Gaps = 15/63 (23%)

Query: 454 PPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPA----GGGKAGGPG 509
           PP       PG P +  PAA+   GG P P P           P PA    GGG AG PG
Sbjct: 177 PPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAP-----------PLPAAQGPGGGGAGAPG 225

Query: 510 VAA 512
           +AA
Sbjct: 226 LAA 228



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 3/67 (4%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGP-LPRSLSRSNSLPHPAGGGKAGGPGV 510
           P PP   T ++P  P  +P      +  +PGP   + R +S +   P P  GG    PG 
Sbjct: 119 PPPPALPTWSVPNGP--SPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGP 176

Query: 511 AAEPGTP 517
              PG P
Sbjct: 177 PPPPGPP 183



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 51/204 (25%), Positives = 70/204 (34%), Gaps = 21/204 (10%)

Query: 371 VNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSA-----GGAPLSPLPKAG 425
           V  V ++  T    +   A    G   G +E+    AAG  SA     GG P  P P   
Sbjct: 67  VRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPP-PALP 125

Query: 426 SITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSR---GGEPG 482
           + +   G + ++ +       +    P P     R +    G   P A       G  P 
Sbjct: 126 TWSVPNGPSPEEVE------QQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPP 179

Query: 483 PGPLPRSLSRSNSLP---HPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKE 539
           PGP P      + +P   H AGGG    P + A  G P   G  A             K 
Sbjct: 180 PGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQG-PGGGGAGAPGLAAAIAGAKLRKV 238

Query: 540 HKRYHSLG--NISRGGSGGSGSGG 561
            K+  + G     +  SG SG GG
Sbjct: 239 SKQEEASGGPTAPKAESGRSGGGG 262


>gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]
          Length = 1690

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 37/120 (30%), Positives = 45/120 (37%), Gaps = 19/120 (15%)

Query: 37   PGDGAARRSGPASAQTPVPPQPPQPPPGPASASG--------PGAAGPASSPPPAGPGPG 88
            PG       GP   + P  P     PPGPA A+G        PG  G    P P GP   
Sbjct: 1215 PGSPGISPPGPRGKKGPPGPPGSSGPPGPAGATGRAPKDIPDPGPPGDQGPPGPDGPRGA 1274

Query: 89   PALPAVRLSLVRL-GEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQR 147
            P  P +  S+  L GEP   G   PP  P   G  G +           +PGC  +  Q+
Sbjct: 1275 PGPPGLPGSVDLLRGEPGDCGLPGPPGPPGPPGPPGYK----------GFPGCDGKDGQK 1324



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/94 (31%), Positives = 31/94 (32%), Gaps = 12/94 (12%)

Query: 36   LPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGA------AGPASSPPPAGPGPGP 89
            LPG     R  P     P PP PP PP  P     PG        GP   P P GP   P
Sbjct: 1280 LPGSVDLLRGEPGDCGLPGPPGPPGPPGPPGYKGFPGCDGKDGQKGPVGFPGPQGPHGFP 1339

Query: 90   ALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
              P  +      G P   G   P   P   G  G
Sbjct: 1340 GPPGEK------GLPGPPGRKGPTGLPGPRGEPG 1367



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 46/186 (24%), Positives = 63/186 (33%), Gaps = 30/186 (16%)

Query: 390  AGADGERSGEEEEEEPEAA-GTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTED 448
            +G DG R  +  + +P +  G     G P SP          FG++G+            
Sbjct: 1062 SGIDGARGPKGNKGDPASHFGPPGPKGEPGSP-----GCPGHFGASGEQGL--------- 1107

Query: 449  VLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGP 508
                 P +   R  PG PG   P  SS   G PG   +P    +   +  P   G  G P
Sbjct: 1108 -----PGIQGPRGSPGRPG---PPGSSGPPGCPGDHGMPGLRGQPGEMGDPGPRGLQGDP 1159

Query: 509  GVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNIS-------RGGSGGSGSGG 561
            G+   PG     G      L   + +   K     H +G          +G  G  GS G
Sbjct: 1160 GIPGPPGIKGPSGSPGLNGLHGLKGQKGTKGASGLHDVGPPGPVGIPGLKGERGDPGSPG 1219

Query: 562  EKPSGP 567
              P GP
Sbjct: 1220 ISPPGP 1225



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 24/70 (34%), Positives = 29/70 (41%), Gaps = 6/70 (8%)

Query: 454  PPLARTRTLPGTPGTTPPAASSSRG--GEPG----PGPLPRSLSRSNSLPHPAGGGKAGG 507
            P L   R  PG+PG +PP     +G  G PG    PGP   +      +P P   G  G 
Sbjct: 1206 PGLKGERGDPGSPGISPPGPRGKKGPPGPPGSSGPPGPAGATGRAPKDIPDPGPPGDQGP 1265

Query: 508  PGVAAEPGTP 517
            PG     G P
Sbjct: 1266 PGPDGPRGAP 1275



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 31/95 (32%), Positives = 34/95 (35%), Gaps = 15/95 (15%)

Query: 33   YKLLPG-DGAARRSGPASAQTPVPPQPPQPPPGPASASG-PGAAGPASSPPPAG-PGPG- 88
            YK  PG DG   + GP     P  P     PPG     G PG  GP   P P G PGP  
Sbjct: 1311 YKGFPGCDGKDGQKGPVGFPGPQGPHGFPGPPGEKGLPGPPGRKGPTGLPGPRGEPGPPA 1370

Query: 89   -----------PALPAVRLSLVRLGEPDSAGAGEP 112
                       P  P +R     +G P   G   P
Sbjct: 1371 DVDDCPRIPGLPGAPGMRGPEGAMGLPGMRGPSGP 1405



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 36/122 (29%), Positives = 40/122 (32%), Gaps = 17/122 (13%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDG--AARRSGPASAQTPVPPQPPQPP 62
           G  G  GP    G       + R     +  +PG    +  R  P     P  P  P  P
Sbjct: 789 GCPGAEGPAGIPGFLGLKGPKGREGHAGFPGVPGPPGHSCERGAPGIPGQPGLPGYPGSP 848

Query: 63  PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSG 122
             P     PG  GP   P PAG    P LP         G P   GA  PP  P   G  
Sbjct: 849 GAPGGKGQPGDVGP---PGPAGMKGLPGLP---------GRP---GAHGPPGLPGIPGPF 893

Query: 123 GD 124
           GD
Sbjct: 894 GD 895



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 52/200 (26%), Positives = 63/200 (31%), Gaps = 71/200 (35%)

Query: 390 AGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDV 449
           AG  G+     + E+    G G  G  PL P  KAG +    G  G              
Sbjct: 592 AGEKGDPGPPGDHEDATPGGKGFPG--PLGPPGKAGPV----GPPGLG------------ 633

Query: 450 LYPHPPLARTRT-LPGTPGTTPPAASSSRGGE--------PG----PG----PLPRSLSR 492
            +P PP  R    +PG PG   P     + G+        PG    PG    P P+    
Sbjct: 634 -FPGPPGERGHPGVPGHPGVRGPDGLKGQKGDTISCNVTYPGRHGPPGFDGPPGPKGFPG 692

Query: 493 SNSLPHPAGG----GKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGN 548
               P  +G     G+ G PG A  PG P                               
Sbjct: 693 PQGAPGLSGSDGHKGRPGTPGTAEIPGPPGF----------------------------- 723

Query: 549 ISRGGSGGSGSGGEKPSGPV 568
             RG  G  G GGEK S PV
Sbjct: 724 --RGDMGDPGFGGEKGSSPV 741



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 35/129 (27%), Positives = 42/129 (32%), Gaps = 3/129 (2%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
            PG PG   P       G PGP  LP S+        P   G  G PG    PG P   G 
Sbjct: 1257 PGPPGDQGPPGPDGPRGAPGPPGLPGSVDLLRG--EPGDCGLPGPPGPPGPPGPPGYKGF 1314

Query: 523  FATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTA 582
                    ++        +  H       G  G  G  G K    +P  R +P       
Sbjct: 1315 PGCDGKDGQKGPVGFPGPQGPHGFPG-PPGEKGLPGPPGRKGPTGLPGPRGEPGPPADVD 1373

Query: 583  LCPRIHEVP 591
             CPRI  +P
Sbjct: 1374 DCPRIPGLP 1382



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 28/87 (32%), Positives = 32/87 (36%), Gaps = 18/87 (20%)

Query: 55   PPQPPQPP-----PGPASASG----PGAAGPASSP----PPAGPGP-----GPALPAVRL 96
            PP P   P     PG   ASG    PG  GP  SP    PP   GP        +P +R 
Sbjct: 1083 PPGPKGEPGSPGCPGHFGASGEQGLPGIQGPRGSPGRPGPPGSSGPPGCPGDHGMPGLRG 1142

Query: 97   SLVRLGEPDSAGAGEPPATPAGLGSGG 123
                +G+P   G    P  P   G  G
Sbjct: 1143 QPGEMGDPGPRGLQGDPGIPGPPGIKG 1169



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 34/104 (32%), Positives = 36/104 (34%), Gaps = 23/104 (22%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQ-----FRTREGFYKLLPGDGAARRSGPASAQTP------ 53
            G  G  GP A + DC  I         R  EG   L    G    SGP     P      
Sbjct: 1361 GPRGEPGPPADVDDCPRIPGLPGAPGMRGPEGAMGL---PGMRGPSGPGCKGEPGLDGRR 1417

Query: 54   -VPPQPPQP-PPGPASASG-------PGAAGPASSPPPAGPGPG 88
             V   P  P PPG    +G       PG  GP   P P G GPG
Sbjct: 1418 GVDGVPGSPGPPGRKGDTGEDGYPGGPGPPGPIGDPGPKGFGPG 1461



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 27/84 (32%), Positives = 30/84 (35%), Gaps = 23/84 (27%)

Query: 63  PGPASASG----PGAAGP----------ASSPPPAGPGPGPALPAVRLS---------LV 99
           PGP    G    PG  GP          A  P P GP   P LP  + S         L 
Sbjct: 465 PGPQGIKGKVGPPGGRGPKGEKGNEGLCACEPGPMGPPGPPGLPGRQGSKGDLGLPGWLG 524

Query: 100 RLGEPDSAGAGEPPATPAGLGSGG 123
             G+P   GA  PP  P   G+ G
Sbjct: 525 TKGDPGPPGAEGPPGLPGKHGASG 548



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 37/128 (28%), Positives = 40/128 (31%), Gaps = 19/128 (14%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G  G  GP    G        F   +G   L   DG   R G     TP   + P PP  
Sbjct: 677 GPPGFDGPPGPKG--------FPGPQGAPGLSGSDGHKGRPG-----TPGTAEIPGPPGF 723

Query: 65  PASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEP-----PATPAGL 119
                 PG  G   S P   PGP P  P V       G+P     G P        P   
Sbjct: 724 RGDMGDPGFGGEKGSSPVGPPGP-PGSPGVNGQKGIPGDPAFGHLGPPGKRGLSGVPGIK 782

Query: 120 GSGGDRVC 127
           G  GD  C
Sbjct: 783 GPRGDPGC 790



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 33/106 (31%), Positives = 38/106 (35%), Gaps = 15/106 (14%)

Query: 411 GSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTP 470
           G  G +P+ P    GS     G  GQ        +  D  + H      R L G PG   
Sbjct: 734 GEKGSSPVGPPGPPGSP----GVNGQK------GIPGDPAFGHLGPPGKRGLSGVPGIKG 783

Query: 471 PAASSSRGGEPGPGPLPRSLSRSNSLPHPAG-GGKAGGPGVAAEPG 515
           P       G  GP  +P  L     L  P G  G AG PGV   PG
Sbjct: 784 PRGDPGCPGAEGPAGIPGFL----GLKGPKGREGHAGFPGVPGPPG 825



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 47/168 (27%), Positives = 51/168 (30%), Gaps = 51/168 (30%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTRE-GFYKLLPGDGAARRSGPASAQTPVPPQPPQPP- 62
            G  G  G     GD      Q R  E G Y    G     R  P     P PP PP PP 
Sbjct: 978  GPPGDDGFPGERGDKGTPGMQGRRGEPGRY----GPPGFHRGEPGEKGQPGPPGPPGPPG 1033

Query: 63   ----------------------PGPASASG-PGAAGPASS---------PP-----PAGP 85
                                  PGP   SG  GA GP  +         PP     P  P
Sbjct: 1034 STGLRGFIGFPGLPGDQGEPGSPGPPGFSGIDGARGPKGNKGDPASHFGPPGPKGEPGSP 1093

Query: 86   G-PG-------PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDR 125
            G PG         LP ++      G P   G+  PP  P   G  G R
Sbjct: 1094 GCPGHFGASGEQGLPGIQGPRGSPGRPGPPGSSGPPGCPGDHGMPGLR 1141



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 29/99 (29%), Positives = 33/99 (33%), Gaps = 19/99 (19%)

Query: 36  LPGDGAARRSGPASAQTPVPPQPPQPPPGPASASG----------PGAAGPASSPPPAGP 85
           +P  G+    GP   Q P+ P      PGP   SG          PGAAG      P G 
Sbjct: 58  VPEKGSRGPPGPPGPQGPIGPLGA---PGPIGLSGEKGMRGDRGPPGAAGDKGDKGPTGV 114

Query: 86  GPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGD 124
              P L  +       G P   G    P      GS GD
Sbjct: 115 PGFPGLDGIP------GHPGPPGPRGKPGMSGHNGSRGD 147



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 6/68 (8%)

Query: 62  PPGPASASGPGAAGPASSPPPAGP--GPG----PALPAVRLSLVRLGEPDSAGAGEPPAT 115
           PPG    SG GA G    P   GP   PG    P  P ++  L  +G+P   G   P   
Sbjct: 286 PPGRKGESGIGAKGEKGIPGFPGPRGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKGD 345

Query: 116 PAGLGSGG 123
           P   G  G
Sbjct: 346 PGNRGHPG 353



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 21/54 (38%), Positives = 21/54 (38%), Gaps = 2/54 (3%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG-GGKAGGPGVAAEPG 515
           PG PG   P       G PGP   PR L      P   G  G  G PG   EPG
Sbjct: 884 PGLPGIPGPFGDDGLPGPPGPKG-PRGLPGFPGFPGERGKPGAEGCPGAKGEPG 936



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 26/77 (33%), Positives = 28/77 (36%), Gaps = 14/77 (18%)

Query: 451  YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLP-HPAGGGKAG--- 506
            +P PP    + LPG PG   P       GEPGP        R   LP  P   G  G   
Sbjct: 1338 FPGPP--GEKGLPGPPGRKGPTGLPGPRGEPGPPADVDDCPRIPGLPGAPGMRGPEGAMG 1395

Query: 507  --------GPGVAAEPG 515
                    GPG   EPG
Sbjct: 1396 LPGMRGPSGPGCKGEPG 1412



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 37/126 (29%), Positives = 40/126 (31%), Gaps = 18/126 (14%)

Query: 462 LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA-----AEPGT 516
           LPG PG      S   GG  GP   P           P   G  G PGV       +PG 
Sbjct: 194 LPGLPG------SWGAGGPAGPTGYPGEPGLVGPPGQPGRPGLKGNPGVGVKGQMGDPGE 247

Query: 517 PFSIGRFATLTLQERRDRGAEKEHKRYHSL-------GNISRGGSGGSGSGGEKPSGPVP 569
               G      L E  D    K  K    +       G   R G  G G+ GEK     P
Sbjct: 248 VGQQGSPGPTLLVEPPDFCLYKGEKGIKGIPGMVGLPGPPGRKGESGIGAKGEKGIPGFP 307

Query: 570 RSRLDP 575
             R DP
Sbjct: 308 GPRGDP 313



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 37/139 (26%), Positives = 43/139 (30%), Gaps = 13/139 (9%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG----DGAARRSGPASAQTPVPPQPPQ 60
           GA G  G   A GD    + +    E      PG     G+  R G A  +    P    
Sbjct: 545 GASGPPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPGSHGRDGHAGEKGDPGPPGDH 604

Query: 61  PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
               P     PG  GP     P GP PG   P         G P   G   P       G
Sbjct: 605 EDATPGGKGFPGPLGPPGKAGPVGP-PGLGFPGPPGERGHPGVPGHPGVRGPDGLK---G 660

Query: 121 SGGDRVCFNLGRELYFYPG 139
             GD +  N+      YPG
Sbjct: 661 QKGDTISCNV-----TYPG 674



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 28/96 (29%), Positives = 32/96 (33%), Gaps = 10/96 (10%)

Query: 40  GAARRSGPASAQTPVPPQPPQPP-----PGPASASG-----PGAAGPASSPPPAGPGPGP 89
           G   R G A A    PP P   P     PG A   G     PG  G   SP   G     
Sbjct: 391 GLLGRPGEACAGMIGPPGPQGFPGLPGLPGEAGIPGRPDSAPGKPGKPGSPGLPGAPGLQ 450

Query: 90  ALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDR 125
            LP   +    +G P   G       P G G  G++
Sbjct: 451 GLPGSSVIYCSVGNPGPQGIKGKVGPPGGRGPKGEK 486



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 32/112 (28%), Positives = 39/112 (34%), Gaps = 10/112 (8%)

Query: 459 TRTLPGTPGTT-PPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
           T+  PG PG   PP      G  G PG       +  S    H    G  G PG   +PG
Sbjct: 525 TKGDPGPPGAEGPPGLPGKHGASGPPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPG 584

Query: 516 TPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGP 567
           +    G        E+ D G   +H+     G    G  G  G  G  P GP
Sbjct: 585 SHGRDGHAG-----EKGDPGPPGDHEDATPGGKGFPGPLGPPGKAG--PVGP 629



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 21/62 (33%), Positives = 24/62 (38%), Gaps = 5/62 (8%)

Query: 462 LPGTPGTTPPAASSSRGGEPG-PGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSI 520
           +PG  G   P       G PG PGP   S  R      P   G+ G PG    PG P   
Sbjct: 799 IPGFLGLKGPKGREGHAGFPGVPGPPGHSCERGA----PGIPGQPGLPGYPGSPGAPGGK 854

Query: 521 GR 522
           G+
Sbjct: 855 GQ 856



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 21/60 (35%), Positives = 23/60 (38%), Gaps = 7/60 (11%)

Query: 463 PGTPGTTPPAASSSRG-----GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PG PG  PP  S  RG     G+PG    P S         P   G  G  G+   PG P
Sbjct: 818 PGVPG--PPGHSCERGAPGIPGQPGLPGYPGSPGAPGGKGQPGDVGPPGPAGMKGLPGLP 875



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 18/78 (23%)

Query: 463  PGTPGTT-PPAASSSRG-----------GEPGPGPLPRSLSRSNSLPHPAG-----GGKA 505
            PG PG   PP ++  RG           GEPG  P P   S  +    P G         
Sbjct: 1023 PGPPGPPGPPGSTGLRGFIGFPGLPGDQGEPG-SPGPPGFSGIDGARGPKGNKGDPASHF 1081

Query: 506  GGPGVAAEPGTPFSIGRF 523
            G PG   EPG+P   G F
Sbjct: 1082 GPPGPKGEPGSPGCPGHF 1099



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 23/66 (34%), Positives = 26/66 (39%), Gaps = 4/66 (6%)

Query: 59  PQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSA-GAGEPPATPA 117
           P  PPG     G   AG    P P G    P LP +       G PDSA G    P +P 
Sbjct: 386 PPGPPGLLGRPGEACAGMIGPPGPQG---FPGLPGLPGEAGIPGRPDSAPGKPGKPGSPG 442

Query: 118 GLGSGG 123
             G+ G
Sbjct: 443 LPGAPG 448



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 30/94 (31%), Positives = 34/94 (36%), Gaps = 8/94 (8%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQP----PPGPASASGP-GAAGPASSPPPAGPGPGPAL 91
           PGD      GPA  +  +P  P +P    PPG     GP G  G    P P GP   P  
Sbjct: 857 PGDVGP--PGPAGMKG-LPGLPGRPGAHGPPGLPGIPGPFGDDGLPGPPGPKGPRGLPGF 913

Query: 92  PAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDR 125
           P       + G     GA   P      G  GDR
Sbjct: 914 PGFPGERGKPGAEGCPGAKGEPGEKGMSGLPGDR 947



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 42/138 (30%), Positives = 47/138 (34%), Gaps = 30/138 (21%)

Query: 452  PHPPLAR-TRTLPGTPGTT----PPAASSSRGGEPGPG-------PLPRSLSRSNSLPHP 499
            P PP  +  R LPG PG       P A    G +  PG       P  R L  +     P
Sbjct: 899  PGPPGPKGPRGLPGFPGFPGERGKPGAEGCPGAKGEPGEKGMSGLPGDRGLRGAKGAIGP 958

Query: 500  AGG----------GKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNI 549
             G           G  G PG   + G P   G   T  +Q RR      E  RY   G  
Sbjct: 959  PGDEGEMAIISQKGTPGEPGPPGDDGFPGERGDKGTPGMQGRRG-----EPGRYGPPG-F 1012

Query: 550  SRGGSGGSGSGGEKPSGP 567
             RG  G  G  G  P GP
Sbjct: 1013 HRGEPGEKGQPG--PPGP 1028


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 44/127 (34%), Positives = 45/127 (35%), Gaps = 33/127 (25%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPP 62
           A GA G +GP  A G                      GAA R GP        P  P  P
Sbjct: 861 AKGARGSAGPPGATGF--------------------PGAAGRVGPPGPSGNAGPPGPPGP 900

Query: 63  PGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEP---PATPAG 118
            G     GP G  GPA  P   GP PGP  PA        GE  S GA  P   P TP  
Sbjct: 901 AGKEGGKGPRGETGPAGRPGEVGP-PGPPGPA--------GEKGSPGADGPAGAPGTPGP 951

Query: 119 LGSGGDR 125
            G  G R
Sbjct: 952 QGIAGQR 958



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 45/142 (31%), Positives = 49/142 (34%), Gaps = 22/142 (15%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQTPVPPQPPQP-- 61
           G  G  GP  A GD  E            +  PGD G     GPA    P P    QP  
Sbjct: 767 GPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGP-PGADGQPGA 825

Query: 62  --PPGPASASG----PGAAGPASSPPPAGPGPGPALPAVRLS------------LVRLGE 103
              PG A A G    PG AGPA  P P G    P     R S              R+G 
Sbjct: 826 KGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGP 885

Query: 104 PDSAGAGEPPATPAGLGSGGDR 125
           P  +G   PP  P   G  G +
Sbjct: 886 PGPSGNAGPPGPPGPAGKEGGK 907



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 38/111 (34%), Positives = 43/111 (38%), Gaps = 24/111 (21%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQ----FRTREGFYKLL--PGD-GAARRSGPASAQTPVPPQ 57
            GA G +GP    GD  E   Q     +   GF  L   PG  G+    GP+ A  P  P+
Sbjct: 1082 GARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPR 1141

Query: 58   PPQPP------------PGPASASGP----GAAGPASSPPPAGPGPGPALP 92
             P               PGP    GP    G AGP   P P GP PGP  P
Sbjct: 1142 GPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGP-PGPPGP 1191



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 37/127 (29%), Positives = 44/127 (34%), Gaps = 23/127 (18%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           GA G +GP    G             GF   +   G A   GP  ++ P   +    PPG
Sbjct: 326 GATGAAGPPGPTGPAGP--------PGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPG 377

Query: 65  PASASGPGAAGPASSPPPAGPG----PG----PALPAVRLSLVRLGEPDSAGAGEPPATP 116
           PA A+GP A  P +   P   G    PG    P  P  R      G     G G PP   
Sbjct: 378 PAGAAGP-AGNPGADGQPGAKGANGAPGIAGAPGFPGAR------GPSGPQGPGGPPGPK 430

Query: 117 AGLGSGG 123
              G  G
Sbjct: 431 GNSGEPG 437



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 55/187 (29%), Positives = 70/187 (37%), Gaps = 27/187 (14%)

Query: 391 GADGERSGEEEEEEPEAAGT----GSAG--GAPLSPLPKAGSITYRFGSAGQDTQFCLWD 444
           G  GER G      P A G     G AG  G+P    PK        G AG+        
Sbjct: 482 GPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSP-----GEAGRPG------ 530

Query: 445 LTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGK 504
             E  L     L  +   PG  G T P   + + G PGP   P +  ++  +  P   G 
Sbjct: 531 --EAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGA 588

Query: 505 AGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEK- 563
           AG PG A E G P   G  A     +  + GA+         G   RG  G +GS G + 
Sbjct: 589 AGEPGKAGERGVPGPPG--AVGPAGKDGEAGAQGPPGPAGPAG--ERGEQGPAGSPGFQG 644

Query: 564 ---PSGP 567
              P+GP
Sbjct: 645 LPGPAGP 651



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/137 (27%), Positives = 46/137 (33%), Gaps = 16/137 (11%)

Query: 381 TRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQF 440
           T A+      G  G      EE +  A G     G P  P  + G  +  F  A      
Sbjct: 445 TGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGA------ 498

Query: 441 CLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPA 500
                 + V  P  P        G+PG   P  S    G PG   LP +   + S   P 
Sbjct: 499 ------DGVAGPKGPAGER----GSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPG 548

Query: 501 GGGKAGGPGVAAEPGTP 517
             GK G PG A + G P
Sbjct: 549 PDGKTGPPGPAGQDGRP 565



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 38/125 (30%), Positives = 46/125 (36%), Gaps = 6/125 (4%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQTPVPPQPPQPPP 63
            GA G  GP    G    +    +  E  +  LPG  G   + GP+ A     P  P  PP
Sbjct: 944  GAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPP 1003

Query: 64   GPASASGPGAAGPASSPPPAG-PG--PGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
            G A    PG +G   +P   G PG    P     R      G P + GA   P      G
Sbjct: 1004 GLAGP--PGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAG 1061

Query: 121  SGGDR 125
              GDR
Sbjct: 1062 KSGDR 1066



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 43/142 (30%), Positives = 48/142 (33%), Gaps = 28/142 (19%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-------------DGAARRSGPASAQ 51
           GA+G +G   A G       Q    E     LPG             DG+  + G     
Sbjct: 707 GAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLT 766

Query: 52  TPVPPQPPQPPPGPASASGP----------GAAGPASSPPPAGPGPGPALPAVRLSLVRL 101
            P+ P  P   PG    SGP          GA G    P P GP      P         
Sbjct: 767 GPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAK 826

Query: 102 GEPDSAG----AGEP-PATPAG 118
           GEP  AG    AG P PA PAG
Sbjct: 827 GEPGDAGAKGDAGPPGPAGPAG 848



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 43/129 (33%), Positives = 49/129 (37%), Gaps = 18/129 (13%)

Query: 454 PPLARTRTLPGTPGTTPPAASSSRG---GEPGP-GPL-------PRSLSRSNSLPHPAG- 501
           P  A  R +PG PG   PA         G PGP GP        P        LP PAG 
Sbjct: 592 PGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGP 651

Query: 502 GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNIS-RGGSGGSGSG 560
            G+AG PG   E G P  +G  A      R +RG   E       G    RG +G  G+ 
Sbjct: 652 PGEAGKPG---EQGVPGDLG--APGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGND 706

Query: 561 GEKPSGPVP 569
           G K     P
Sbjct: 707 GAKGDAGAP 715



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 33/116 (28%), Positives = 36/116 (31%), Gaps = 37/116 (31%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPP---------------------------PGPASAS 69
           P     R   P     P PP PP PP                           PGP   S
Sbjct: 125 PAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPS 184

Query: 70  GP-GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGD 124
           GP G  GP  +P P G    P  P         GEP ++G   P   P   G  GD
Sbjct: 185 GPRGLPGPPGAPGPQGFQGPPGEP---------GEPGASGPMGPRGPPGPPGKNGD 231



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 36/130 (27%), Positives = 44/130 (33%), Gaps = 20/130 (15%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQ----------TP 53
           GA+G +GP    G+           +   + LPG+ G     GPA A+           P
Sbjct: 275 GAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPP 334

Query: 54  VPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
            P  P  PP  P +    G AGP       GP      P         G P  AGA  P 
Sbjct: 335 GPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEP---------GPPGPAGAAGPA 385

Query: 114 ATPAGLGSGG 123
             P   G  G
Sbjct: 386 GNPGADGQPG 395



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 40/129 (31%), Positives = 48/129 (37%), Gaps = 29/129 (22%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G  G +GP    G           +EG      G G    +GPA     V P  P   PG
Sbjct: 887 GPSGNAGPPGPPGPAG--------KEG------GKGPRGETGPAGRPGEVGPPGP---PG 929

Query: 65  PASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRL-------GEPDSAGAGEPPATP 116
           PA   G PGA GPA +P      PGP   A +  +V L       G P   G    P   
Sbjct: 930 PAGEKGSPGADGPAGAPGT----PGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQ 985

Query: 117 AGLGSGGDR 125
              G+ G+R
Sbjct: 986 GPSGASGER 994



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 41/132 (31%), Positives = 46/132 (34%), Gaps = 21/132 (15%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQ-------TPVP- 55
           G +G  GP    G+  E  +     +   K  PG  G     GPA  +        P P 
Sbjct: 419 GPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPT 478

Query: 56  --PQPPQPPPGPASASGPGAAGPASSPPPAGP--GPGPALPAVRLSLVRLGEPDSAGAGE 111
             P PP    GP S   PGA G A    PAG    PGPA P         G P  AG   
Sbjct: 479 GLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPK--------GSPGEAGRPG 530

Query: 112 PPATPAGLGSGG 123
               P   G  G
Sbjct: 531 EAGLPGAKGLTG 542



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 39/117 (33%), Positives = 42/117 (35%), Gaps = 30/117 (25%)

Query: 37  PG-DGAARRSGPASAQTPVPPQPPQPP-----------PGPASASG-------------P 71
           PG DG     GPA       P PP PP           PGP  A+G             P
Sbjct: 547 PGPDGKTGPPGPAGQDGR--PGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPP 604

Query: 72  GAAGPASSPPPAGP--GPGPALPA-VRLSLVRLGEPDSAGAGEPPATPAGLGSGGDR 125
           GA GPA     AG    PGPA PA  R      G P   G   P   P   G  G++
Sbjct: 605 GAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQ 661



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 27/88 (30%), Positives = 32/88 (36%), Gaps = 7/88 (7%)

Query: 43  RRSGPASAQTPVPPQPPQPPPGPASASGP-GAAGPASSPP------PAGPGPGPALPAVR 95
           + +G  S   P+ P  P+  PGP  A GP G  GP   P       P GP   P  P   
Sbjct: 170 KSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKN 229

Query: 96  LSLVRLGEPDSAGAGEPPATPAGLGSGG 123
                 G+P   G   PP      G  G
Sbjct: 230 GDDGEAGKPGRPGERGPPGPQGARGLPG 257



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 39/125 (31%), Positives = 45/125 (36%), Gaps = 17/125 (13%)

Query: 5   GAEGGSGPGAAMG--DCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPP 62
           G  G  GP  A G    A +    +   GF  L   DGA   +GPA         P   P
Sbjct: 242 GERGPPGPQGARGLPGTAGLPGM-KGHRGFSGL---DGAKGDAGPAG--------PKGEP 289

Query: 63  PGPASASGPGAAGPASSPPPAG-PG-PGPALPAVRLSLV-RLGEPDSAGAGEPPATPAGL 119
             P     PG  GP   P   G PG PGPA            G P   G   PP  P  +
Sbjct: 290 GSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAV 349

Query: 120 GSGGD 124
           G+ G+
Sbjct: 350 GAKGE 354



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 40/118 (33%), Positives = 43/118 (36%), Gaps = 7/118 (5%)

Query: 5   GAEGGSGPGAAMGD---CAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
           GA+G  GP    G      E   +    E     LPG     R GP S   P        
Sbjct: 446 GAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGP-PGERGGPGSRGFP-GADGVAG 503

Query: 62  PPGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAG 118
           P GPA   G PG AGP  SP  AG      LP  +      G P   G   PP  PAG
Sbjct: 504 PKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPG-PAG 560



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 8/111 (7%)

Query: 460 RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
           R LPG PG   P       GEPG    P +         P   GK G  G A +PG P  
Sbjct: 187 RGLPGPPGAPGPQGFQGPPGEPGE---PGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGE 243

Query: 520 ---IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGP 567
               G      L         K H+ +  L   ++G +G +G  GE P  P
Sbjct: 244 RGPPGPQGARGLPGTAGLPGMKGHRGFSGLDG-AKGDAGPAGPKGE-PGSP 292



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 46/132 (34%), Positives = 49/132 (37%), Gaps = 36/132 (27%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQ-TPVPPQP--PQ 60
           G  G  GP  A G    +        GF    PG  GAA   G A  +  P PP    P 
Sbjct: 563 GRPGPPGPPGARGQAGVM--------GF----PGPKGAAGEPGKAGERGVPGPPGAVGPA 610

Query: 61  PPPGPASASGP-GAAGPASS---PPPAG-PG----PGPALPAVRLSLVRLGEPDSAGAGE 111
              G A A GP G AGPA       PAG PG    PGPA           G P  AG   
Sbjct: 611 GKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPA-----------GPPGEAGKPG 659

Query: 112 PPATPAGLGSGG 123
               P  LG+ G
Sbjct: 660 EQGVPGDLGAPG 671



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 43/140 (30%), Positives = 51/140 (36%), Gaps = 34/140 (24%)

Query: 391 GADGERSGEEEEEEPEAAGT----GSAGGA-PLSPLPKAGSITYRF--GSAGQDTQFCLW 443
           GADG+   + E  +  A G     G AG A P  P+   G+   +   GSAG        
Sbjct: 818 GADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAG-------- 869

Query: 444 DLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGP-GPLPRSLSRSNSLPHPAGG 502
                     PP A     PG  G   P   S   G PGP GP  +   +      P G 
Sbjct: 870 ----------PPGATG--FPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKG-----PRGE 912

Query: 503 -GKAGGPGVAAEPGTPFSIG 521
            G AG PG    PG P   G
Sbjct: 913 TGPAGRPGEVGPPGPPGPAG 932



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 36/106 (33%), Positives = 41/106 (38%), Gaps = 25/106 (23%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG-GKAGGPGVAAEPGTPFSIG 521
            PG PG   PA  S   GE GP               PAG  G  G  G A   G     G
Sbjct: 1051 PGAPGPVGPAGKSGDRGETGPA-------------GPAGPVGPVGARGPAGPQGPRGDKG 1097

Query: 522  RFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEK-PSG 566
                    E+ DRG  K H+ +  L    +G  G  GS GE+ PSG
Sbjct: 1098 ETG-----EQGDRGI-KGHRGFSGL----QGPPGPPGSPGEQGPSG 1133



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 30/104 (28%), Positives = 33/104 (31%), Gaps = 26/104 (25%)

Query: 46  GPASAQTPVPPQPPQPPPG----PASASGPGAAGPASSPPPAGPG--------------- 86
           GP     P  P+ P  PPG    P     PG  GP   P P G G               
Sbjct: 112 GPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKS 171

Query: 87  ------PGPALPAVRLSLV-RLGEPDSAGAGEPPATPAGLGSGG 123
                 PGP  P+    L    G P   G   PP  P   G+ G
Sbjct: 172 TGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASG 215



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 39/133 (29%), Positives = 44/133 (33%), Gaps = 32/133 (24%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG----PASAQTPVPPQPPQ 60
           GA+G +GP    G+        R   G        G A R G    P +      P  P 
Sbjct: 497 GADGVAGPKGPAGE--------RGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPG 548

Query: 61  P-----PPGPASASGPGAAGPASSPPPAGPG-----PGPALPAVRLSLVRLGEPDSAGAG 110
           P     PPGPA   G    GP   P   G       PGP   A        GEP  AG  
Sbjct: 549 PDGKTGPPGPAGQDG--RPGPPGPPGARGQAGVMGFPGPKGAA--------GEPGKAGER 598

Query: 111 EPPATPAGLGSGG 123
             P  P  +G  G
Sbjct: 599 GVPGPPGAVGPAG 611



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 19/53 (35%), Positives = 21/53 (39%), Gaps = 9/53 (16%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
           PG PG   P+     GG PGP        + NS   P   G  G  G   EPG
Sbjct: 409 PGFPGARGPSGPQGPGGPPGP--------KGNS-GEPGAPGSKGDTGAKGEPG 452



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 35/110 (31%), Positives = 42/110 (38%), Gaps = 16/110 (14%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG-GGKAGGPGVAAEPGTPFSIGR 522
            G PG   P+ +S   G PGP   P        L  P G  G+ G PG    PG   S G 
Sbjct: 980  GEPGKQGPSGASGERGPPGPMGPP-------GLAGPPGESGREGAPGAEGSPGRDGSPG- 1031

Query: 523  FATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEK----PSGPV 568
             A     E    G         + G +  G +G SG  GE     P+GPV
Sbjct: 1032 -AKGDRGETGPAGPPGAPGAPGAPGPV--GPAGKSGDRGETGPAGPAGPV 1078



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 25/93 (26%), Positives = 33/93 (35%), Gaps = 7/93 (7%)

Query: 39  DGAARRSGPASAQTPVPPQPPQPPPGPASASG-------PGAAGPASSPPPAGPGPGPAL 91
           DG A + G    + P  PQ  +  PG A   G        G  G      PAGP   P  
Sbjct: 232 DGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGS 291

Query: 92  PAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGD 124
           P    +  ++G     G    P  P   G+ G+
Sbjct: 292 PGENGAPGQMGPRGLPGERGRPGAPGPAGARGN 324



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 17/58 (29%), Positives = 21/58 (36%)

Query: 464 GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           G  G+  P       G PGP           +   P   G  G PG+A  PG P + G
Sbjct: 359 GPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARG 416



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 35/129 (27%), Positives = 43/129 (33%), Gaps = 26/129 (20%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQTPVPPQPPQPPP 63
           G +G  GP    G+  +   Q          +PGD GA   SG    +     +  Q PP
Sbjct: 641 GFQGLPGPAGPPGEAGKPGEQG---------VPGDLGAPGPSGARGERGFPGERGVQGPP 691

Query: 64  GPASASGP-------GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATP 116
           GPA   G        GA G A +P   G    P L          G P   GA   P   
Sbjct: 692 GPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQ---------GMPGERGAAGLPGPK 742

Query: 117 AGLGSGGDR 125
              G  G +
Sbjct: 743 GDRGDAGPK 751



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 12/67 (17%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRS--NSLPHPAG----------GGKAGGPGV 510
            PG+PG   P+ +S   G  GP     +  +   N LP P G           G  G PG 
Sbjct: 1123 PGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGP 1182

Query: 511  AAEPGTP 517
               PG P
Sbjct: 1183 PGPPGPP 1189



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 30/114 (26%), Positives = 33/114 (28%), Gaps = 2/114 (1%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
           PG PG    A      G+PG    P           P   G AG PG     G P + G 
Sbjct: 805 PGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKG- 863

Query: 523 FATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPA 576
            A  +       G      R    G     G  G      K  G  PR    PA
Sbjct: 864 -ARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPA 916



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 35/101 (34%), Positives = 39/101 (38%), Gaps = 13/101 (12%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRT-REGF--YKLLPG-DGAARRSGPASAQTPV-PPQPP 59
            GA G  GP   MG          + REG    +  PG DG+    G      P  PP  P
Sbjct: 989  GASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAP 1048

Query: 60   QPP--PGPASASGP----GAAGPASSPPPAGP--GPGPALP 92
              P  PGP   +G     G  GPA    P GP    GPA P
Sbjct: 1049 GAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGP 1089



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 58/214 (27%), Positives = 69/214 (32%), Gaps = 49/214 (22%)

Query: 391 GADGERSGEEEEEEPEAAGT-GSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDV 449
           G++G +    E   P  AG  G AG       P A       G AG              
Sbjct: 362 GSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGA------------- 408

Query: 450 LYPHPPLARTRTLPGTPGTTP--------PAASSSRG-----GEPG-------PGPLPRS 489
             P  P AR  + P  PG  P        P A  S+G     GEPG       PGP    
Sbjct: 409 --PGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEE 466

Query: 490 LSR-SNSLPHPAG----GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYH 544
             R +   P P G     G+ GGPG    PG     G           +RG+        
Sbjct: 467 GKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAG-----PKGPAGERGSPGPAGPKG 521

Query: 545 SLGNISRGGSGG-SGSGG--EKPSGPVPRSRLDP 575
           S G   R G  G  G+ G    P  P P  +  P
Sbjct: 522 SPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGP 555



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 36/124 (29%), Positives = 45/124 (36%), Gaps = 37/124 (29%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG-------GKAGGP---GVAA 512
           PG+PG       +   G+ GP  LP    R  + P PAG        G AG P   G A 
Sbjct: 289 PGSPG------ENGAPGQMGPRGLPGERGRPGA-PGPAGARGNDGATGAAGPPGPTGPAG 341

Query: 513 EPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSR 572
            PG P ++G         + + G +             RG  G  G  GE P  P P   
Sbjct: 342 PPGFPGAVG--------AKGEAGPQG-----------PRGSEGPQGVRGE-PGPPGPAGA 381

Query: 573 LDPA 576
             PA
Sbjct: 382 AGPA 385



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 32/120 (26%), Positives = 43/120 (35%), Gaps = 23/120 (19%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG-GKAGGPGVAAEPGTPFSIG 521
           PG  G   PA      G+PG   +P  L      P P+G  G+ G PG     G P   G
Sbjct: 640 PGFQGLPGPAGPPGEAGKPGEQGVPGDL----GAPGPSGARGERGFPGERGVQGPPGPAG 695

Query: 522 RFATLTLQERRDRGAEKEHKRYHSLGNI-------SRGGSGGSGSGGEKPSGPVPRSRLD 574
                       RGA        + G+        S+G  G  G  GE+ +  +P  + D
Sbjct: 696 -----------PRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGD 744



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 18/58 (31%), Positives = 20/58 (34%)

Query: 464 GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           G+PG       +   G PGP   P     S         G  G PG   EPG P   G
Sbjct: 755 GSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAG 812



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 36/131 (27%), Positives = 38/131 (29%), Gaps = 55/131 (41%)

Query: 3    AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPP 62
            A GA G  GP    GD  E                       +GPA    PV P   + P
Sbjct: 1050 APGAPGPVGPAGKSGDRGE-----------------------TGPAGPAGPVGPVGARGP 1086

Query: 63   PGPASASG----------------------PGAAGPASSPPPAGP--GPGPALPAVRLSL 98
             GP    G                       G  GP  SP   GP    GPA P      
Sbjct: 1087 AGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPR----- 1141

Query: 99   VRLGEPDSAGA 109
               G P SAGA
Sbjct: 1142 ---GPPGSAGA 1149



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 21/64 (32%), Positives = 23/64 (35%), Gaps = 9/64 (14%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRS-----NSLPHPAG----GGKAGGPGVAAE 513
            PG PG+      S   G  GP   P S         N LP P G     G+ G  G    
Sbjct: 1120 PGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGP 1179

Query: 514  PGTP 517
            PG P
Sbjct: 1180 PGPP 1183



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 24/76 (31%), Positives = 25/76 (32%), Gaps = 16/76 (21%)

Query: 462 LPGTPGTTPPAASSSRGGEPGPG---------------PLPRSLSRSNSLPHPAGG-GKA 505
           LPG PG   P      GG   P                P P   S    LP P G  G  
Sbjct: 140 LPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQ 199

Query: 506 GGPGVAAEPGTPFSIG 521
           G  G   EPG P + G
Sbjct: 200 GFQGPPGEPGEPGASG 215


>gi|39812378 RAN binding protein 9 [Homo sapiens]
          Length = 729

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 28/66 (42%), Positives = 32/66 (48%), Gaps = 5/66 (7%)

Query: 47  PASAQTPVPPQPPQPPPGPASASGPGAAGP-----ASSPPPAGPGPGPALPAVRLSLVRL 101
           P    T  PP PP PPP PASA+ P +  P     A+ P PAG  P PAL A   +    
Sbjct: 74  PPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPF 133

Query: 102 GEPDSA 107
              DSA
Sbjct: 134 PHGDSA 139



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 17/70 (24%)

Query: 57  QPPQPPPGPASASGPGAAGPASSPPPAGPGP--GPALPAVRLSLVRLGEPDSAGAGEPPA 114
           QPP PPP              S PPPA   P  G  LPA          P +  AG  PA
Sbjct: 4   QPPPPPPQQQQQQ-----QQLSPPPPAALAPVSGVVLPA----------PPAVSAGSSPA 48

Query: 115 TPAGLGSGGD 124
              G G+GG+
Sbjct: 49  GSPGGGAGGE 58



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 5/83 (6%)

Query: 449 VLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGP 508
           +L+P PP       P  P   PP  +S+     GP P P  L+     P PAGG      
Sbjct: 68  LLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGP-PAPPGLAAG---PGPAGGAPTPAL 123

Query: 509 GVAAEPGTPFSIGRFATLTLQER 531
              +    PF  G  A L  QE+
Sbjct: 124 VAGSSAAAPFPHGDSA-LNEQEK 145



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 28/85 (32%), Positives = 29/85 (34%), Gaps = 24/85 (28%)

Query: 53  PVPP------QPPQPPPGPASASGPGAAG------PASSPPPAGPGPGPALPAVRLSLVR 100
           P PP       P   P G A   G GAA       P   PPPA   P P  P        
Sbjct: 36  PAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPP------- 88

Query: 101 LGEPDSAGAGEP---PATPAGLGSG 122
              P  A A  P   P  P GL +G
Sbjct: 89  --PPPPASAAAPASGPPAPPGLAAG 111



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 25/82 (30%), Positives = 27/82 (32%), Gaps = 20/82 (24%)

Query: 55  PPQPPQ----------PPPG----------PASASGPGAAGPASSPPPAGPGPGPALPAV 94
           PP PPQ          PPP           PA  +    + PA SP     G G    A 
Sbjct: 6   PPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAA 65

Query: 95  RLSLVRLGEPDSAGAGEPPATP 116
            L L     P  A A  PP  P
Sbjct: 66  ALLLHPPPPPPPATAAPPPPPP 87


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 36/90 (40%), Positives = 39/90 (43%), Gaps = 11/90 (12%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAG------PGPGPA 90
           P    A R  PA+A    PP  P PPP PA  +   AA PA +P  A       P PGPA
Sbjct: 109 PAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVA---AAAPARAPRAAAAAATAPPSPGPA 165

Query: 91  LPAVRLS-LVRLGEPDSAGAGEPP-ATPAG 118
            P  R      L  P  A A  P  A PAG
Sbjct: 166 QPGPRAQRAAPLAAPPPAPAAPPAVAPPAG 195



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/82 (36%), Positives = 36/82 (43%), Gaps = 15/82 (18%)

Query: 42  ARRSGPASAQTPVPPQPPQPPP-----GPASASGPGAAGPASSPPPAGP--GPGPALPAV 94
           A R+  A+A  P  P P QP P      P +A  P  A P +  PPAGP   P PA+ A 
Sbjct: 148 APRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAA- 206

Query: 95  RLSLVRLGEPDSAGAGEPPATP 116
                   EP      +PPA P
Sbjct: 207 -------REPPLPPPPQPPAPP 221



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 34/106 (32%), Positives = 43/106 (40%), Gaps = 7/106 (6%)

Query: 27  RTREGFYKLLPGDGAARRS--GPASAQTPVPPQPPQ----PPPGPASASGPGAAGPASSP 80
           RTR    KL+      R S  G  S +     QPP+    PP  P +  G  AA  A++P
Sbjct: 68  RTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRAPRGAPAAAAAAAP 127

Query: 81  PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPAT-PAGLGSGGDR 125
           PP    P P  P    +  R     +A A  PP+  PA  G    R
Sbjct: 128 PPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQR 173



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 25/75 (33%), Positives = 30/75 (40%), Gaps = 7/75 (9%)

Query: 42  ARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRL 101
           AR    A+A    PP P    PGP +      A P ++PPPA   P    P       R 
Sbjct: 146 ARAPRAAAAAATAPPSPGPAQPGPRAQ----RAAPLAAPPPAPAAPPAVAPPAG---PRR 198

Query: 102 GEPDSAGAGEPPATP 116
             P +  A EPP  P
Sbjct: 199 APPPAVAAREPPLPP 213



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 3/56 (5%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALP 92
           P  G A+  GP + +      PP  P  P + + P  AGP  +PPPA     P LP
Sbjct: 160 PSPGPAQ-PGPRAQRAAPLAAPPPAPAAPPAVAPP--AGPRRAPPPAVAAREPPLP 212



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 27/76 (35%), Positives = 28/76 (36%), Gaps = 6/76 (7%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAG---PGPGPALPA 93
           P  G  R   PA A    P  PP  PP P     P    P   PPP G      G A P 
Sbjct: 192 PPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQP--PPPQPQPPPEGGAVRAGGAARPV 249

Query: 94  VRLSLVR-LGEPDSAG 108
               +VR LG    AG
Sbjct: 250 SLREVVRYLGGSGGAG 265



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 22/64 (34%), Positives = 25/64 (39%), Gaps = 9/64 (14%)

Query: 41  AARRSGPASAQTPVPPQPPQPPPGPASAS---------GPGAAGPASSPPPAGPGPGPAL 91
           AA    PA+     PP  P+  P PA A+          P A      PPP  P P P  
Sbjct: 178 AAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEG 237

Query: 92  PAVR 95
            AVR
Sbjct: 238 GAVR 241


>gi|134142824 forkhead box D2 [Homo sapiens]
          Length = 495

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 37/85 (43%), Positives = 45/85 (52%), Gaps = 7/85 (8%)

Query: 42  ARRSGPASAQTPVPP-QPPQPPPGPASASGPGAAGPASSPPPA---GPGPGPA-LPAVRL 96
           A  +  A  Q  VPP +   PPPGP +AS    AG A +P PA   GPGPGPA LPA   
Sbjct: 298 AAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGLPAFLG 357

Query: 97  SLVRLGEPDSAGAGEPPA--TPAGL 119
           + +   +   A +  PPA  T AGL
Sbjct: 358 AELGCAKAFYAASLSPPAAGTAAGL 382



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 45/172 (26%), Positives = 55/172 (31%), Gaps = 19/172 (11%)

Query: 407 AAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTP 466
           A G    G AP  P P   +  +   +A    Q  +         P PP A      G  
Sbjct: 276 AYGAPPPGPAP-HPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASV--FAGAG 332

Query: 467 GTTPPAASSSRGGEPGPGPLPRSLSR---------SNSLPHPAGGGKAGGPGVAAEPGTP 517
               PA +S  G  PGP  LP  L           + SL  PA G  AG P      G  
Sbjct: 333 SAPAPAPASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLK 392

Query: 518 FSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVP 569
              G  A          GA    +   S+ +I   G GG+   G     P P
Sbjct: 393 TDAGGGA-------GGGGAGAGQRPSFSIDHIMGHGGGGAAPPGAGEGSPGP 437



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 34/121 (28%), Positives = 41/121 (33%), Gaps = 38/121 (31%)

Query: 39  DGAARRSGPASAQTPVPPQPPQPPPGP--------ASASGPGA----------------- 73
           +G+  R      + P+PP  P P P P        A+A  PGA                 
Sbjct: 213 NGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGL 272

Query: 74  AGPASSPPPAGPGPGP--------ALPAVRLSLVRLGEPDSAGAGEPPATP-----AGLG 120
           A PA   PP GP P P           A   +  +L  P    A  PP  P     AG G
Sbjct: 273 ALPAYGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAG 332

Query: 121 S 121
           S
Sbjct: 333 S 333



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 35/121 (28%), Positives = 41/121 (33%), Gaps = 23/121 (19%)

Query: 4   GGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPP 63
           GGA     PGA +   A   +      G+   LP  GA           P P   P P P
Sbjct: 245 GGAAAAGDPGAFLPGFAAYGAY---GYGYGLALPAYGAP---------PPGPAPHPHPHP 292

Query: 64  GPASASGPGAAGPA--SSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGS 121
              + +   AA P   S PP     P P  P   +          AGAG  PA     GS
Sbjct: 293 HAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASV---------FAGAGSAPAPAPASGS 343

Query: 122 G 122
           G
Sbjct: 344 G 344



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 12/22 (54%), Positives = 14/22 (63%)

Query: 63  PGPASASGPGAAGPASSPPPAG 84
           PGP +A+  GAAGP   PP  G
Sbjct: 97  PGPGAAAARGAAGPGPGPPSGG 118



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 13/26 (50%), Positives = 17/26 (65%)

Query: 64  GPASASGPGAAGPASSPPPAGPGPGP 89
           G A+A+G    G A++   AGPGPGP
Sbjct: 89  GAAAAAGSPGPGAAAARGAAGPGPGP 114


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 38/117 (32%), Positives = 50/117 (42%), Gaps = 15/117 (12%)

Query: 20  AEIKSQFRTREGFYKLLPGDGAARRSGPASAQTP----VPPQPPQPPPGPASASGPGAAG 75
           AE +SQ + +E  +       ++++  P  +  P     PP P  PP GP  A      G
Sbjct: 366 AEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPG 425

Query: 76  PASSPPPAGPGPG-------PALPAVRLSLVRL---GEPDSAGAGEPPATPAGLGSG 122
           P +  PP GP PG       P +P +R  L RL   G P     G PP  P GL  G
Sbjct: 426 PPTGLPP-GPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPG 481



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 27/68 (39%), Positives = 29/68 (42%), Gaps = 4/68 (5%)

Query: 53  PVPPQPPQPPPGPASASGPGA---AGPASSPPPAGPGPGPALPA-VRLSLVRLGEPDSAG 108
           P P +PP PPPGP     PG      P   PPPA PG  P  P  +R  LV    P   G
Sbjct: 462 PPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPG 521

Query: 109 AGEPPATP 116
              P   P
Sbjct: 522 LFPPAPLP 529



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 24/66 (36%), Positives = 27/66 (40%), Gaps = 4/66 (6%)

Query: 37  PGDGAARRSGPASAQTPVPPQPPQ-PPPGPASASGPGAAGPASSPPPAGPGPG-PALPAV 94
           PG    R   P       PP  P  PPPGP     PG   P   PPP  P P  P +P  
Sbjct: 445 PGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGP--PPRGPPPRLPPPAPPGIPPP 502

Query: 95  RLSLVR 100
           R  ++R
Sbjct: 503 RPGMMR 508



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 23/65 (35%), Positives = 25/65 (38%), Gaps = 5/65 (7%)

Query: 64  GPASASGPGAAGPASSPP-----PAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAG 118
           G ++AS    A P S PP     P  PGP P  P     L   G P     G PP  P  
Sbjct: 382 GTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPF 441

Query: 119 LGSGG 123
           L   G
Sbjct: 442 LRPPG 446


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 31/120 (25%), Positives = 53/120 (44%), Gaps = 4/120 (3%)

Query: 274 RNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVC 333
           R   +++     P+    FS DG+ LA  S+D  ++V+          +  +   + C  
Sbjct: 92  RGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAK 151

Query: 334 WSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGAD 393
           +SPDGR +V+  ED  + +W  T  + V        + N V F+P  T       +AG+D
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGT----CIASAGSD 207



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 27/87 (31%), Positives = 41/87 (47%)

Query: 292 FSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVT 351
           FSP G  LA  S+D  +R++  D        K++   +  V +S DG+++ T  ED  + 
Sbjct: 68  FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127

Query: 352 VWSFTEGRVVARGHGHKSWVNAVAFDP 378
           VWS    R +   + H  WV    F P
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSP 154



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 40/161 (24%), Positives = 62/161 (38%), Gaps = 8/161 (4%)

Query: 292 FSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVT 351
           FSPDGR +   S+D  ++++   +           G    V ++P G  + + G D  V 
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211

Query: 352 VWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGE-RSGEEEEEEPEAAGT 410
           VW     +++     H   VN ++F P    +      A +DG  +  +  E        
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHP----SGNYLITASSDGTLKILDLLEGRLIYTLQ 267

Query: 411 GSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLY 451
           G  G        K G +   F S G DTQ  LW    D L+
Sbjct: 268 GHTGPVFTVSFSKGGEL---FASGGADTQVLLWRTNFDELH 305



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 29/109 (26%), Positives = 49/109 (44%), Gaps = 4/109 (3%)

Query: 285 GPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTG 344
           G  N   F+P G  +A    D  ++V+      L    + + GG+ C+ + P G Y++T 
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246

Query: 345 GEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGAD 393
             D  + +    EGR++    GH   V  V+F    ++  E   + GAD
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF----SKGGELFASGGAD 291



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 22/77 (28%), Positives = 35/77 (45%)

Query: 277 LAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSP 336
           L  + V  G +N  +F P G +L   S DG L++       L   ++ + G +  V +S 
Sbjct: 221 LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSK 280

Query: 337 DGRYVVTGGEDDLVTVW 353
            G    +GG D  V +W
Sbjct: 281 GGELFASGGADTQVLLW 297



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 17/63 (26%), Positives = 29/63 (46%)

Query: 317 LLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAF 376
           +L    K +   +  +  SP+G+ + T   D  + +W+F       R  GHK  V +V F
Sbjct: 9   VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68

Query: 377 DPY 379
            P+
Sbjct: 69  SPH 71


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 39/115 (33%), Positives = 46/115 (40%), Gaps = 4/115 (3%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQTPVPPQPPQPPP 63
            G+ G  GP    GD  E   +       ++  PG+ GA    GPA  Q  +    P  P 
Sbjct: 1080 GSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPR 1139

Query: 64   GPASASG-PGAAGPASSPPPAGPGPGP-ALPAVRLSLVRLGEPDSAGAGEPPATP 116
            GP   SG PG  G +  P P GP PGP      R S    G P   G   PP  P
Sbjct: 1140 GPVGPSGPPGKDGTSGHPGPIGP-PGPRGNRGERGSEGSPGHPGQPGPPGPPGAP 1193



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 40/127 (31%), Positives = 48/127 (37%), Gaps = 12/127 (9%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG-PASAQTPVPPQPPQPPP 63
           G+ G  GP      C      +  +   Y +  G      +G P  A  P PP PP    
Sbjct: 130 GSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSG 189

Query: 64  GPASASGPGAAGPASSPPPAGP-GP-------GPALPAVR-LSLVRLGEPDSAGAGEPPA 114
            P S   PG  GP   P  AGP GP       GP+ PA +     R G P   G   PP 
Sbjct: 190 HPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPG 249

Query: 115 T--PAGL 119
              PAG+
Sbjct: 250 IKGPAGI 256



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 42/122 (34%), Positives = 48/122 (39%), Gaps = 16/122 (13%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G  GGSGP    G    +K + R   G      G GAA    P +   P PP     P  
Sbjct: 843 GPPGGSGPAGPPGPQG-VKGE-RGSPG------GPGAA--GFPGARGLPGPPGSNGNPGP 892

Query: 65  PASASGPGAAGPASSPPPAGPGPGPALPAV---RLSLVRLGEPDSAGAGEPPATPAGLGS 121
           P  +  PG  GP   P PAG    P  P V   +    + GE  S GA  PP  P  LG 
Sbjct: 893 PGPSGSPGKDGP---PGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGI 949

Query: 122 GG 123
            G
Sbjct: 950 AG 951



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 47/154 (30%), Positives = 51/154 (33%), Gaps = 47/154 (30%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPA--SAQTPVPPQPPQPP 62
           GA G  GP  A G+        R R G    LPG   AR +  A  S   P PP PP   
Sbjct: 294 GAPGPMGPRGAPGE--------RGRPG----LPGAAGARGNDGARGSDGQPGPPGPPGTA 341

Query: 63  PGPASASGPGAAGPASSP----------------------PPAGPG----------PGPA 90
             P S    G  GPA SP                      PP  PG           GPA
Sbjct: 342 GFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPA 401

Query: 91  -LPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
            +P     +   G P  AGA   P    G G  G
Sbjct: 402 GIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPG 435



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 58/200 (29%), Positives = 67/200 (33%), Gaps = 31/200 (15%)

Query: 389 AAGADGERSGEEEEEEPEAAGTGSAGGAPLSP-LPKAGSITYRFGSAGQDTQFCLWDLTE 447
           A G  GE     E   P   G   A G    P LP A       G+ G D Q        
Sbjct: 280 APGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQ-------- 331

Query: 448 DVLYPHPP-LARTRTLPGTPGT---TPPAASSSRGGEPGP--GPLPRSLSRSNSLPHPAG 501
               P PP    T   PG+PG      PA S    G PG    P P+  + +   P P G
Sbjct: 332 ----PGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPG 387

Query: 502 -GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSG 560
             G  GG G     G P + G            RG         + G   RGG+G  G  
Sbjct: 388 INGSPGGKGEMGPAGIPGAPGLMGA--------RGPPGPAGANGAPG--LRGGAGEPGKN 437

Query: 561 GEKPSGPVPRSRLDPAKVLG 580
           G K   P PR     A + G
Sbjct: 438 GAK-GEPGPRGERGEAGIPG 456



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 38/134 (28%), Positives = 49/134 (36%), Gaps = 27/134 (20%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGF-----YKLLPGD----GAARRSGPASAQ---- 51
           GA G +GP  A G+          R+G       + +PG     G+  + GP  +Q    
Sbjct: 510 GAPGPAGPRGAAGEPG--------RDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESG 561

Query: 52  TPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGE 111
            P PP P  P   P     PG  G   +P   G   GP  P  +      G P   G   
Sbjct: 562 RPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQ------GPPGKNGETG 615

Query: 112 PPATPAGLGSGGDR 125
           P   P   G GGD+
Sbjct: 616 PQGPPGPTGPGGDK 629



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 38/121 (31%), Positives = 45/121 (37%), Gaps = 17/121 (14%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP-PP 63
           G  G +GPG   GD      Q        + LPG G     GP         +P +P P 
Sbjct: 618 GPPGPTGPGGDKGDTGPPGPQG------LQGLPGTG-----GPPGENG----KPGEPGPK 662

Query: 64  GPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSG 122
           G A A G PG  G A +P   GP      P +R      G     GA  PP  P   G+ 
Sbjct: 663 GDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTP 722

Query: 123 G 123
           G
Sbjct: 723 G 723



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 31/95 (32%), Positives = 34/95 (35%), Gaps = 10/95 (10%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGP-------ASASGPGAAGPASS---PPPAGPGPGP 89
           G     GP     P     P  PPGP        S  GPGAAG   +   P P G    P
Sbjct: 831 GEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNP 890

Query: 90  ALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGD 124
             P    S  + G P  AG    P +P   G  GD
Sbjct: 891 GPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGD 925



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 32/91 (35%), Positives = 37/91 (40%), Gaps = 6/91 (6%)

Query: 38   GDGAARRSG-PASAQTPVPPQPPQPPPGPASASGP----GAAGPASSPPPAGPGPGPALP 92
            G G    +G P +   P  P PP P  GPA  SG     G AGPA +P PAG    P   
Sbjct: 1030 GKGDRGENGSPGAPGAPGHPGPPGPV-GPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQ 1088

Query: 93   AVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
              R      GE  +AG       P   G+ G
Sbjct: 1089 GPRGDKGETGERGAAGIKGHRGFPGNPGAPG 1119



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 45/146 (30%), Positives = 53/146 (36%), Gaps = 24/146 (16%)

Query: 389 AAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTED 448
           A G +GE  G+ E   P   G    GG P    P  GS     G AG         +  +
Sbjct: 814 APGQNGEPGGKGERGAP---GEKGEGGPPGVAGPPGGS-----GPAGPPGP---QGVKGE 862

Query: 449 VLYPHPPLAR----TRTLPGTPGTT----PPAASSSRGGEPGPGP-----LPRSLSRSNS 495
              P  P A      R LPG PG+     PP  S S G +  PGP      P S   S  
Sbjct: 863 RGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGP 922

Query: 496 LPHPAGGGKAGGPGVAAEPGTPFSIG 521
                  G+ G PG    PG P  +G
Sbjct: 923 KGDAGQPGEKGSPGAQGPPGAPGPLG 948



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 57/204 (27%), Positives = 67/204 (32%), Gaps = 51/204 (25%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDL 445
           A  A G  G+     E   P  AG     G    P P+ G      G+AG          
Sbjct: 667 APGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGK-----GAAGP--------- 712

Query: 446 TEDVLYPHPP-LARTRTLPGTPGTT----PPAASSSRGGEPGPGPL-------PRSLSRS 493
                 P PP  A T  L G PG       P     +G   GPG         PR  +  
Sbjct: 713 ------PGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGP 766

Query: 494 NSLPHPAG-------GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSL 546
              P PAG       GG  G PG+A   G+P            ER + G         + 
Sbjct: 767 IGPPGPAGQPGDKGEGGAPGLPGIAGPRGSP-----------GERGETGPPGPAGFPGAP 815

Query: 547 G-NISRGGSGGSGSGGEKPSGPVP 569
           G N   GG G  G+ GEK  G  P
Sbjct: 816 GQNGEPGGKGERGAPGEKGEGGPP 839



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 34/121 (28%), Positives = 40/121 (33%), Gaps = 9/121 (7%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           GA G  GP  A G    ++     R G     P        GP +   P          G
Sbjct: 708 GAAGPPGPPGAAGTPG-LQGMPGERGGLGSPGPKGDKGEPGGPGADGVP-------GKDG 759

Query: 65  PASASGP-GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
           P   +GP G  GPA  P   G G  P LP +       GE    G   P   P   G  G
Sbjct: 760 PRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNG 819

Query: 124 D 124
           +
Sbjct: 820 E 820



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 32/119 (26%), Positives = 38/119 (31%), Gaps = 1/119 (0%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G +G  GP   +G            EG    LPG  A  R  P       PP P   P  
Sbjct: 756 GKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGI-AGPRGSPGERGETGPPGPAGFPGA 814

Query: 65  PASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
           P     PG  G   +P   G G  P +          G P   G      +P G G+ G
Sbjct: 815 PGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAG 873



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 44/147 (29%), Positives = 56/147 (38%), Gaps = 40/147 (27%)

Query: 3    AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPP 62
            A GA G  GP   +G     KS  R   G        G A   GPA ++    PQ P+  
Sbjct: 1042 APGAPGHPGPPGPVGPAG--KSGDRGESG------PAGPAGAPGPAGSRGAPGPQGPRGD 1093

Query: 63   PG----------------PASASGPGAAGPA------SSPPPAGP-GP-GPALPAVRLSL 98
             G                P +   PG+ GPA       SP PAGP GP GP+ P      
Sbjct: 1094 KGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPP----- 1148

Query: 99   VRLGEPDSAGAGEPPATPAGLGSGGDR 125
               G+  ++G   P   P   G+ G+R
Sbjct: 1149 ---GKDGTSGHPGPIGPPGPRGNRGER 1172



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 52/203 (25%), Positives = 66/203 (32%), Gaps = 35/203 (17%)

Query: 387 ATAAGADGERSGEEEEEEPEAAGT----GSAGGAPLSPLPKAGSITYRFGSAGQDTQFCL 442
           A A GA G R G  E  +  A G     G  G A +  +P A     + GS G+     L
Sbjct: 419 AGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGL 478

Query: 443 WDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG 502
                      P  A  R  PG  G   P       G  G    P       +   P   
Sbjct: 479 -----------PGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRD 527

Query: 503 GKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNIS------------ 550
           G  GGPG+   PG+P   G        +    G++ E  R    G               
Sbjct: 528 GVPGGPGMRGMPGSPGGPGSDG-----KPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPG 582

Query: 551 -RGGSGGSGSGGEK--PSGPVPR 570
            +G  G  G  GE+  P GP P+
Sbjct: 583 PKGNDGAPGKNGERGGPGGPGPQ 605



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 39/140 (27%), Positives = 46/140 (32%), Gaps = 35/140 (25%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-GAARRSGPASAQTPV--------- 54
            GA G  G     GD  +               PG+ G+    GP  A  P+         
Sbjct: 912  GAPGSPGVSGPKGDAGQ---------------PGEKGSPGAQGPPGAPGPLGIAGITGAR 956

Query: 55   ----PPQPPQP--PPGPASASG----PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEP 104
                PP  P P   PGP    G    PGA G +    P GP   P L        R G P
Sbjct: 957  GLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNP 1016

Query: 105  DSAGAGEPPATPAGLGSGGD 124
             S G      +P G G  G+
Sbjct: 1017 GSDGLPGRDGSPGGKGDRGE 1036



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 27/90 (30%), Positives = 27/90 (30%), Gaps = 13/90 (14%)

Query: 38  GDGAARRSGPASAQTPVPPQPPQPPPGPASASG----PGAAGPASSPPPAGPGPGPALPA 93
           G G     GP        PQ P  P GP    G    PG  G    P   GP      P 
Sbjct: 598 GPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKP- 656

Query: 94  VRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
                   GEP   G    P  P G G  G
Sbjct: 657 --------GEPGPKGDAGAPGAPGGKGDAG 678



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 33/118 (27%), Positives = 48/118 (40%), Gaps = 30/118 (25%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPG 509
           P PP A TR         PP     +G  G+PGP  +P               G+ G PG
Sbjct: 89  PQPPTAPTR---------PPNGQGPQGPKGDPGPPGIP---------------GRNGDPG 124

Query: 510 VAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGP 567
           +  +PG+P S G      + E    G +    +Y S  ++  G + G  +G   P+GP
Sbjct: 125 IPGQPGSPGSPG---PPGICESCPTGPQNYSPQYDSY-DVKSGVAVGGLAGYPGPAGP 178



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 53/203 (26%), Positives = 71/203 (34%), Gaps = 43/203 (21%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGGAP-----LSPLPKAGSITYRFGSAGQDTQF 440
           AA A G DG R  + +   P   GT    G+P     + P    GS     G+ GQ  + 
Sbjct: 316 AAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGS----NGAPGQRGE- 370

Query: 441 CLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPH 498
                        P         G PG  PP  + S G  GE GP  +P +     +   
Sbjct: 371 -------------PGPQGHAGAQGPPG--PPGINGSPGGKGEMGPAGIPGAPGLMGARGP 415

Query: 499 PAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDR-------GAEKEHKRYHSLGNISR 551
           P   G  G PG+    G P   G       +  R         GA+ E  +  S G    
Sbjct: 416 PGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPG--EP 473

Query: 552 GGSGGSGSGGEK-------PSGP 567
           G +G  G+ GE+       P+GP
Sbjct: 474 GANGLPGAAGERGAPGFRGPAGP 496



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 20/54 (37%), Positives = 24/54 (44%), Gaps = 6/54 (11%)

Query: 462 LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
           L G PGT  P   + + GEPGP         + +   P G G AG PG    PG
Sbjct: 640 LQGLPGTGGPPGENGKPGEPGPK------GDAGAPGAPGGKGDAGAPGERGPPG 687



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 14/63 (22%)

Query: 54  VPPQPPQPPPGPASASGPGAAGPASSP-PPAGPGPG--PALPAVRLSLVRLGEPDSAGAG 110
           V PQPP  P  P +  GP   GP   P PP  PG    P +P         G+P S G+ 
Sbjct: 87  VCPQPPTAPTRPPNGQGP--QGPKGDPGPPGIPGRNGDPGIP---------GQPGSPGSP 135

Query: 111 EPP 113
            PP
Sbjct: 136 GPP 138



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 36/127 (28%), Positives = 43/127 (33%), Gaps = 8/127 (6%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD-------GAARRSGPASAQTPVPPQ 57
           GA+G  GP    G+           E      PG+       GAA   G    + P  P 
Sbjct: 438 GAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPN 497

Query: 58  PPQPPPGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATP 116
                 GPA   G PG AGP  +    G    P  P +R      G P S G   PP + 
Sbjct: 498 GIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQ 557

Query: 117 AGLGSGG 123
              G  G
Sbjct: 558 GESGRPG 564



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 37/125 (29%), Positives = 44/125 (35%), Gaps = 13/125 (10%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVL 450
           G+ G +  + E   P A G     G P  P    G      G AGQ       D  E   
Sbjct: 735 GSPGPKGDKGEPGGPGADGVPGKDG-PRGPTGPIGPP----GPAGQPG-----DKGEGGA 784

Query: 451 YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
              P +A  R  PG  G T P   +   G PG    P       +   P   G+ G PGV
Sbjct: 785 PGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGA---PGEKGEGGPPGV 841

Query: 511 AAEPG 515
           A  PG
Sbjct: 842 AGPPG 846



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 34/109 (31%), Positives = 38/109 (34%), Gaps = 10/109 (9%)

Query: 464 GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
           G PG   P   +   G PGP   P       +   P   G  G PG   E G P   G F
Sbjct: 753 GVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAG-F 811

Query: 524 ATLTLQE-----RRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGP 567
                Q      + +RGA  E       G    G  GGSG  G  P GP
Sbjct: 812 PGAPGQNGEPGGKGERGAPGEKGEGGPPG--VAGPPGGSGPAG--PPGP 856



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 52/184 (28%), Positives = 60/184 (32%), Gaps = 35/184 (19%)

Query: 389  AAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTED 448
            A G  GER     +  P  AGT    G   +P   +  +  R GS G        D  E+
Sbjct: 985  ANGLSGERGPPGPQGLPGLAGTAGEPGRDGNP--GSDGLPGRDGSPGGKG-----DRGEN 1037

Query: 449  VLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGP 508
               P  P A     PG PG   PA  S   GE GP                   G AG P
Sbjct: 1038 GS-PGAPGAPGH--PGPPGPVGPAGKSGDRGESGP------------------AGPAGAP 1076

Query: 509  GVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGS-----GGEK 563
            G A   G P   G          R     K H+ +   GN    GS G        G   
Sbjct: 1077 GPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFP--GNPGAPGSPGPAGQQGAIGSPG 1134

Query: 564  PSGP 567
            P+GP
Sbjct: 1135 PAGP 1138



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 36/120 (30%), Positives = 47/120 (39%), Gaps = 18/120 (15%)

Query: 415 GAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDV----LYPHPPLARTRTLPGTPGTT- 469
           G+P SP P     +   G      Q+  +D+   V    L  +P  A     PG PGT+ 
Sbjct: 130 GSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSG 189

Query: 470 PPAASSSRG-----GEPG-------PGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            P +  S G     GEPG       PGP P ++  S         G+ G PG    PG P
Sbjct: 190 HPGSPGSPGYQGPPGEPGQAGPSGPPGP-PGAIGPSGPAGKDGESGRPGRPGERGLPGPP 248



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 34/118 (28%), Positives = 40/118 (33%), Gaps = 10/118 (8%)

Query: 463 PGTPGTTPPAASSSRGGEPGP-GPL-PRSLSRSNSLPHPAGG-------GKAGGPGVAAE 513
           PG+ G   P  S    G PGP GP  PR        P P G        G+ GGPG    
Sbjct: 545 PGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGP 604

Query: 514 PGTPFSIGRFATLTLQERRDRGAEK-EHKRYHSLGNISRGGSGGSGSGGEKPSGPVPR 570
            G P   G             G +K +       G     G+GG      KP  P P+
Sbjct: 605 QGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPK 662



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 34/130 (26%), Positives = 45/130 (34%), Gaps = 17/130 (13%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAP----LSPLPKAGSITYRFGSAGQDTQFCLWDLT 446
           G  GE+    E   P  AG   A G P    +   P    +    G  G D +       
Sbjct: 498 GIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGK------- 550

Query: 447 EDVLYPHPPLARTRT-LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKA 505
                P PP ++  +  PG PG + P       G PGP     +  ++     P G G  
Sbjct: 551 -----PGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQ 605

Query: 506 GGPGVAAEPG 515
           G PG   E G
Sbjct: 606 GPPGKNGETG 615



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 21/61 (34%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 63  PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSG 122
           PGPA     G  GP   P  +G    P  P  +      GEP  AG   PP  P  +G  
Sbjct: 173 PGPA-----GPPGPPGPPGTSGHPGSPGSPGYQ---GPPGEPGQAGPSGPPGPPGAIGPS 224

Query: 123 G 123
           G
Sbjct: 225 G 225



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 36/113 (31%), Positives = 37/113 (32%), Gaps = 13/113 (11%)

Query: 457 ARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGT 516
           A  R  PG  G    A    R G PG GP  R +  S     P   GK G PG   E G 
Sbjct: 506 AGERGAPGPAGPRGAAGEPGRDGVPG-GPGMRGMPGSPG--GPGSDGKPGPPGSQGESGR 562

Query: 517 PFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGG--SGSGGEKPSGP 567
           P   G            RG           GN    G  G   G GG  P GP
Sbjct: 563 PGPPG--------PSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGP 607



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 18/73 (24%)

Query: 463  PGTPGTTPPAASSSRGGEPGP----GPL----PRSLSRSNSLPHPAGG----------GK 504
            PG PG+  PA      G PGP    GP+    P     ++  P P G           G 
Sbjct: 1115 PGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGS 1174

Query: 505  AGGPGVAAEPGTP 517
             G PG   +PG P
Sbjct: 1175 EGSPGHPGQPGPP 1187



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 58/224 (25%), Positives = 71/224 (31%), Gaps = 47/224 (20%)

Query: 378 PYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQD 437
           P +  A+     AG+ G      +  EP   G   A G P  P      I    G  G  
Sbjct: 344 PGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPP-----GINGSPGGKG-- 396

Query: 438 TQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-----PLPRSLSR 492
                 ++    +   P L   R  PG  G           GEPG       P PR    
Sbjct: 397 ------EMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERG 450

Query: 493 SNSLPHPAGG----GKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGN 548
              +P   G     GK G PG     G P + G           +RGA            
Sbjct: 451 EAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAG-----------ERGAPG---------- 489

Query: 549 ISRGGSGGSGSGGEK-PSGPVPRSRLDPAKVLGTALCPRIHEVP 591
             RG +G +G  GEK P+G   R    PA   G A  P    VP
Sbjct: 490 -FRGPAGPNGIPGEKGPAG--ERGAPGPAGPRGAAGEPGRDGVP 530



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 49/187 (26%), Positives = 61/187 (32%), Gaps = 51/187 (27%)

Query: 389  AAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKA-GSITYRFGSAGQDTQFCLWDLTE 447
            A G+ G    + +  +P   G+  A G P +P P     IT   G AG            
Sbjct: 913  APGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGP----------- 961

Query: 448  DVLYPHPPLARTRTLPGTPGTT----PPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAG 501
                  P +   R  PG  G       P A+   G  G PGP  LP     + +   P  
Sbjct: 962  ------PGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLP---GLAGTAGEPGR 1012

Query: 502  GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGG 561
             G  G  G+    G+P   G           DRG            N S G  G  G  G
Sbjct: 1013 DGNPGSDGLPGRDGSPGGKG-----------DRGE-----------NGSPGAPGAPGHPG 1050

Query: 562  EKPSGPV 568
              P GPV
Sbjct: 1051 --PPGPV 1055



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 35/117 (29%), Positives = 42/117 (35%), Gaps = 31/117 (26%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGPASASG-PGAAGPASSPPPAG----PGPG------ 88
           G     GPA           + PPGPA A+G PG  G A  P   G    PGP       
Sbjct: 393 GGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEA 452

Query: 89  --PALPAVRLSLVRLGEPDSAGA----------GEP----PATPAGL----GSGGDR 125
             P +P  +    + G P   GA          G P    PA P G+    G  G+R
Sbjct: 453 GIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGER 509



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 23/62 (37%), Positives = 24/62 (38%), Gaps = 5/62 (8%)

Query: 62  PPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGS 121
           PPGP    G GAAGP   P P G    P L  +      LG P   G    P  P   G 
Sbjct: 700 PPGPEG--GKGAAGP---PGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGV 754

Query: 122 GG 123
            G
Sbjct: 755 PG 756



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 28/95 (29%), Positives = 31/95 (32%), Gaps = 18/95 (18%)

Query: 47  PASAQTPVPPQPPQPPPG-PASASGPGAAGPASSPPPAGP---------GPGPALPAVRL 96
           P + Q P  P+    PPG P     PG  G   SP   GP         GP    P    
Sbjct: 98  PPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDS 157

Query: 97  SLVR--------LGEPDSAGAGEPPATPAGLGSGG 123
             V+         G P  AG   PP  P   G  G
Sbjct: 158 YDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPG 192



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 24/74 (32%), Positives = 26/74 (35%), Gaps = 10/74 (13%)

Query: 454 PPLARTRTLP-GTPGTTPPAASSSRGGEPGPGPL--------PRSLSRSNSLPHPAG-GG 503
           PP     T P G PG T P       G PGP  L        P   +     P P G  G
Sbjct: 607 PPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAG 666

Query: 504 KAGGPGVAAEPGTP 517
             G PG   + G P
Sbjct: 667 APGAPGGKGDAGAP 680


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 6/90 (6%)

Query: 292 FSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFG---GLLCVCWSPDGRYVVTGGEDD 348
           F P G  +A  SQD  ++++    +  +G +  Y G    + C+ +SPDG+++ +  +D 
Sbjct: 113 FHPYGEFVASGSQDTNIKLW---DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169

Query: 349 LVTVWSFTEGRVVARGHGHKSWVNAVAFDP 378
            V +W  T G++++   GH   VN V F P
Sbjct: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHP 199



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 18/76 (23%), Positives = 34/76 (44%)

Query: 303 SQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVA 362
           SQ G +RV+  ++  +   +  +   +  + + P G +V +G +D  + +W       V 
Sbjct: 82  SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF 141

Query: 363 RGHGHKSWVNAVAFDP 378
           R  GH   V  + F P
Sbjct: 142 RYRGHSQAVRCLRFSP 157



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 21/87 (24%), Positives = 41/87 (47%)

Query: 292 FSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVT 351
           FSPDG+ LA  + D  ++++   +  +      + G +  V + P+   + +G  D  + 
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214

Query: 352 VWSFTEGRVVARGHGHKSWVNAVAFDP 378
            W   + +VV+   G    V +V F+P
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNP 241



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/114 (28%), Positives = 44/114 (38%), Gaps = 18/114 (15%)

Query: 338 GRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERS 397
           GR + TGG+D  V +WS  +   +    GH S V +V  +      EE   A    G +S
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN----TPEELIVA----GSQS 84

Query: 398 GEEEEEEPEAAGT------GSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDL 445
           G     + EAA          A    L   P    +     S  QDT   LWD+
Sbjct: 85  GSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV----ASGSQDTNIKLWDI 134



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 18/65 (27%), Positives = 32/65 (49%)

Query: 285 GPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTG 344
           GP+N   F P+   LA  S D  +R +  +   +   ++   G +  V ++PDG  + +G
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249

Query: 345 GEDDL 349
            +D L
Sbjct: 250 CQDSL 254


>gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo
           sapiens]
          Length = 1424

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 48/124 (38%), Gaps = 9/124 (7%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVP--PQPPQPP 62
           G+ G +GP    G   + +   +  +G        G A   G  S  TPVP  P PP PP
Sbjct: 605 GSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPP 664

Query: 63  --PGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
             PGP    G PG+ G    P   GP   P +P +       G P   G    P T   L
Sbjct: 665 GHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFP----GPPGPKGDQGFPGTKGSL 720

Query: 120 GSGG 123
           G  G
Sbjct: 721 GCPG 724



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/109 (36%), Positives = 42/109 (38%), Gaps = 19/109 (17%)

Query: 34  KLLPGD-GAARRSGPASAQTPVPPQPPQP-PPGPASASGPGAAGPASSP-------PPAG 84
           K LPG  G    SG    Q P P  P  P  PGPA  +GP   GP   P        P  
Sbjct: 577 KGLPGPKGELALSGEKGDQGP-PGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGA 635

Query: 85  PG-PGPALPAVRLSLVR--------LGEPDSAGAGEPPATPAGLGSGGD 124
           PG PG A P   LS+           G P   G   PP  P  LG  GD
Sbjct: 636 PGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGD 684



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 4/70 (5%)

Query: 454  PPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
            P   +  +LPG+PG  PP      G  GEPGP   P +L        P   GK G PG A
Sbjct: 1348 PGTLKIISLPGSPG--PPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405

Query: 512  AEPGTPFSIG 521
             E G   S G
Sbjct: 1406 GEKGNKGSKG 1415



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 11/131 (8%)

Query: 451  YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRS-----LSRSNSLPHPAGGGKA 505
            +P PP      +PG  G   P  S    G PGP   P S          S+ HP   G  
Sbjct: 1223 FPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHP---GPK 1279

Query: 506  GGPGVAAEPGTPFSIGRFATLTLQ-ERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKP 564
            G PG A + G P  +G   T  L   R D G +         GN    GS G   G   P
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGP-PGPIGP 1338

Query: 565  SGPVPRSRLDP 575
             GP P  R DP
Sbjct: 1339 KGP-PGVRGDP 1348



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 31/78 (39%), Positives = 35/78 (44%), Gaps = 18/78 (23%)

Query: 463 PGTPGTTPPAASSSRG--GEPG----------PGPL----PRS-LSRSNSLPHPAGG-GK 504
           PG+PG   PA     G  GEPG          PGP     PR  LS S  +P P G  G 
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 505 AGGPGVAAEPGTPFSIGR 522
            G PG    PG P S+G+
Sbjct: 664 PGHPGPQGPPGIPGSLGK 681



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 43/135 (31%), Positives = 51/135 (37%), Gaps = 17/135 (12%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQ--------FRTREGFYKLLPGDGAARRSGPASAQTPVPP 56
           G +G  G    MG+   IK Q        FR    +Y      G     GP   +    P
Sbjct: 312 GVKGNRGFPGLMGEDG-IKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGP 370

Query: 57  QPPQPPPG-PASASGPGAAGPASSPPPAGPG-PGPALPAVRLSLVRLGEPDSAG-AGEP- 112
           Q P  PPG P S   PG++ P     P  PG  G      R     +G P S G AG P 
Sbjct: 371 QGPSGPPGVPGS---PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPG 427

Query: 113 -PATPAGLGSGGDRV 126
            P +P   G  GD V
Sbjct: 428 LPGSPGPPGPPGDIV 442



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 42/157 (26%), Positives = 50/157 (31%), Gaps = 36/157 (22%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG---------------P 47
           A G +G SGP    G     +   R   G+  L    G   R G               P
Sbjct: 367 ARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSP 426

Query: 48  ASAQTPVPPQPP------QPPPGPASASG-------PGAAGPASSPP------PAGPGPG 88
               +P PP PP      + PPG     G       PG  GP   P       P  PGP 
Sbjct: 427 GLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPP 486

Query: 89  --PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P LP +       G   +AG    P +P   G  G
Sbjct: 487 GLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG 523



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/113 (25%), Positives = 38/113 (33%), Gaps = 6/113 (5%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
            PG PG   PA      G PG   LP        L      G  G PG+   PG P   G 
Sbjct: 1088 PGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGS 1147

Query: 523  FATLTLQERRDR------GAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVP 569
               + ++  + R        EK            RG  G  G+ G++ +   P
Sbjct: 1148 PGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFP 1200



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 38/130 (29%), Positives = 45/130 (34%), Gaps = 22/130 (16%)

Query: 2    AAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A  G  G  G   A GD        R   GF  L    GA   +GP     P   +    
Sbjct: 1177 APPGPRGNPGAQGAKGD--------RGAPGFPGLPGRKGAMGDAGPRG---PTGIEGFPG 1225

Query: 62   PPGPASASGPGAAG----PASSPPPAGPG----PGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPG   A  PG  G    P S   P  PG    PG  +  ++     +G P   G   PP
Sbjct: 1226 PPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKG---PP 1282

Query: 114  ATPAGLGSGG 123
             T   +G  G
Sbjct: 1283 GTAGDMGPPG 1292



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 34/101 (33%), Positives = 37/101 (36%), Gaps = 21/101 (20%)

Query: 43   RRSGPASAQTPVPPQPP--QPPPGPASASG-PGAAGPASSPPPAGPGPGPALPAVR---- 95
            R   P +   P P   P  Q  PG     G PG  G    P P GP  GP  P VR    
Sbjct: 1293 RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGP-KGP--PGVRGDPG 1349

Query: 96   -LSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
             L ++ L          GEP   G   PP  P  LG  G R
Sbjct: 1350 TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPR 1390



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 63  PGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSL-VR--LGEPDSAGAGEPPATPAG 118
           PGP  + G  G  GP   P P GP   P LP +  S  VR   G P  +G+   P TP  
Sbjct: 54  PGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN 113

Query: 119 LGSGG 123
            G  G
Sbjct: 114 TGPYG 118



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 33/120 (27%), Positives = 41/120 (34%), Gaps = 31/120 (25%)

Query: 398 GEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLA 457
           G   + EP   GT    GAP  P           G AG                P   L+
Sbjct: 617 GYGPQGEPGLQGTQGVPGAPGPP-----------GEAG----------------PRGELS 649

Query: 458 RTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            +  +PG PG   P       G  GP  +P SL +      P   G+ G PG+   PG P
Sbjct: 650 VSTPVPGPPG---PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGF-PGPP 705



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 3/67 (4%)

Query: 454  PPLARTRTLPGTPGTTPPAA---SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
            P L   + LPG  G   P     S+   GEPG   +P S+            G  G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 511  AAEPGTP 517
            A  PG P
Sbjct: 1038 AGRPGLP 1044



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 30/105 (28%), Positives = 34/105 (32%), Gaps = 19/105 (18%)

Query: 35   LLPGDGAARRSGPASAQTPVPPQPPQPP----------------PGPASASGPGAAGPAS 78
            ++PG     R  P S  +P  P PP PP                PGP     PG AG   
Sbjct: 1233 IIPGQ-TGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGP--PGTAGDMG 1289

Query: 79   SPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P   G    P LP  R      G P   G    P     +G  G
Sbjct: 1290 PPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPG 1334



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 24/80 (30%), Positives = 30/80 (37%), Gaps = 9/80 (11%)

Query: 55   PPQP--PQPPPGPASASG-------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPD 105
            PP P  P+ PPG     G       PG+ GP  +P   G    P  P    +L   G   
Sbjct: 1332 PPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRG 1391

Query: 106  SAGAGEPPATPAGLGSGGDR 125
              G    P TP   G  G++
Sbjct: 1392 KPGKDGKPGTPGPAGEKGNK 1411



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 16/96 (16%)

Query: 5   GAEGGSGPGAAMG--DCAEIKSQFRTREGF--------YKLLPGDGAARRSGPASAQTPV 54
           G  G +GP   +G   C+  K +    +GF        Y  +PG    +    A A+   
Sbjct: 109 GTPGNTGPYGLVGVPGCSGSKGE----QGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEED 164

Query: 55  PPQPPQPPPGPASASGP-GAAGPASSPPPAGPGPGP 89
                +  PG   A GP G  GP   P P GP PGP
Sbjct: 165 IELDAKGDPGLPGAPGPQGLPGPPGFPGPVGP-PGP 199



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 26/72 (36%), Positives = 28/72 (38%), Gaps = 2/72 (2%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPG-PG-PLPRSLSRSNSLPHPAGGGKAGGPG 509
           P P  AR    P  P   P +  SSR G  G PG P  +        P     G  G PG
Sbjct: 362 PGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPG 421

Query: 510 VAAEPGTPFSIG 521
            A  PG P S G
Sbjct: 422 CAGSPGLPGSPG 433



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/120 (27%), Positives = 43/120 (35%), Gaps = 27/120 (22%)

Query: 460 RTLPGTPGTT-PPAASSSRG--------GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
           R  PG PG   PP      G        G PGP   P +  +  S   P   G+ G PG 
Sbjct: 873 RGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGG-SGGSGSGGEKPSGPVP 569
             E G                 D+G     +  H +G+    G  G +G+ GEK +  VP
Sbjct: 933 KGEQG-----------------DKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVP 975



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 34/111 (30%), Positives = 39/111 (35%), Gaps = 14/111 (12%)

Query: 460  RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
            R +PG PG           G PGP   P       S  +P   G  G PG     G P S
Sbjct: 972  RGVPGMPGL------KGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGS 1025

Query: 520  IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSG-SGGEKPSGPVP 569
             G+  TL    R  R         H L    +G  G  G S G +P  P P
Sbjct: 1026 KGKRGTLGFPGRAGRPG---LPGIHGL----QGDKGEPGYSEGTRPGPPGP 1069



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 39/150 (26%), Positives = 49/150 (32%), Gaps = 34/150 (22%)

Query: 391 GADGERS--GEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYRFGSAG----------- 435
           G+ GER   G++    P + G   + G P SP P    G I +R G  G           
Sbjct: 401 GSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSP 460

Query: 436 ----------QDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGP 485
                     +    C    T+    P PP      LPG PG         R G  G   
Sbjct: 461 GIPGVDGPKGEPGLLC----TQCPYIPGPP-----GLPGLPGLHGVKGIPGRQGAAGLKG 511

Query: 486 LPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
            P S   +     P   G  G PG+  E G
Sbjct: 512 SPGSPGNTGLPGFPGFPGAQGDPGLKGEKG 541



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 12/130 (9%)

Query: 462  LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
            +PG+ G         R G PG  P    L      P  + G + G PG   +PG P  +G
Sbjct: 1022 MPGSKGKRGTLGFPGRAGRPGL-PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMG 1080

Query: 522  RFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGT 581
            +           +G   +      LG     G+ GS      P  P P   L    + G 
Sbjct: 1081 K-----------KGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGL 1129

Query: 582  ALCPRIHEVP 591
               P I   P
Sbjct: 1130 LGPPGIRGPP 1139



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 35/112 (31%), Positives = 37/112 (33%), Gaps = 5/112 (4%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PGT        R G PG   LP           P   G+ G PG     G P  IG  
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDP 575
                +  R D G  K      S G    G  G  G  GE P  P P   L P
Sbjct: 1340 GPPGV--RGDPGTLKIISLPGSPG--PPGTPGEPGMQGE-PGPPGPPGNLGP 1386



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPL----PRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PG PG+   +    RG    PG       R     +++  P   G AG PG+   PG P
Sbjct: 377 PGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPP 435



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 20/61 (32%), Positives = 24/61 (39%), Gaps = 1/61 (1%)

Query: 53   PVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGA-GE 111
            P  P PP  P  P     PG  GP  +  P GP   P       +    GE  + G+ GE
Sbjct: 1357 PGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSKGE 1416

Query: 112  P 112
            P
Sbjct: 1417 P 1417



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           PG PG     A +  GG   PG  P    R NS  H    G+ G PG+   PGTP + G
Sbjct: 735 PGLPGAKGEPAVAMPGGPGTPG-FPGE--RGNSGEH----GEIGLPGLPGLPGTPGNEG 786



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 18/55 (32%), Positives = 22/55 (40%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            PG  G+  P       G PG    P +L   +    P   G  G PG+  EPG P
Sbjct: 1324 PGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPP 1378


>gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo
           sapiens]
          Length = 1494

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 48/124 (38%), Gaps = 9/124 (7%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVP--PQPPQPP 62
           G+ G +GP    G   + +   +  +G        G A   G  S  TPVP  P PP PP
Sbjct: 605 GSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPP 664

Query: 63  --PGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
             PGP    G PG+ G    P   GP   P +P +       G P   G    P T   L
Sbjct: 665 GHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFP----GPPGPKGDQGFPGTKGSL 720

Query: 120 GSGG 123
           G  G
Sbjct: 721 GCPG 724



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/109 (36%), Positives = 42/109 (38%), Gaps = 19/109 (17%)

Query: 34  KLLPGD-GAARRSGPASAQTPVPPQPPQP-PPGPASASGPGAAGPASSP-------PPAG 84
           K LPG  G    SG    Q P P  P  P  PGPA  +GP   GP   P        P  
Sbjct: 577 KGLPGPKGELALSGEKGDQGP-PGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGA 635

Query: 85  PG-PGPALPAVRLSLVR--------LGEPDSAGAGEPPATPAGLGSGGD 124
           PG PG A P   LS+           G P   G   PP  P  LG  GD
Sbjct: 636 PGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGD 684



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 4/70 (5%)

Query: 454  PPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
            P   +  +LPG+PG  PP      G  GEPGP   P +L        P   GK G PG A
Sbjct: 1348 PGTLKIISLPGSPG--PPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405

Query: 512  AEPGTPFSIG 521
             E G   S G
Sbjct: 1406 GEKGNKGSKG 1415



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 11/131 (8%)

Query: 451  YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRS-----LSRSNSLPHPAGGGKA 505
            +P PP      +PG  G   P  S    G PGP   P S          S+ HP   G  
Sbjct: 1223 FPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHP---GPK 1279

Query: 506  GGPGVAAEPGTPFSIGRFATLTLQ-ERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKP 564
            G PG A + G P  +G   T  L   R D G +         GN    GS G   G   P
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGP-PGPIGP 1338

Query: 565  SGPVPRSRLDP 575
             GP P  R DP
Sbjct: 1339 KGP-PGVRGDP 1348



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 31/78 (39%), Positives = 35/78 (44%), Gaps = 18/78 (23%)

Query: 463 PGTPGTTPPAASSSRG--GEPG----------PGPL----PRS-LSRSNSLPHPAGG-GK 504
           PG+PG   PA     G  GEPG          PGP     PR  LS S  +P P G  G 
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 505 AGGPGVAAEPGTPFSIGR 522
            G PG    PG P S+G+
Sbjct: 664 PGHPGPQGPPGIPGSLGK 681



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 43/135 (31%), Positives = 51/135 (37%), Gaps = 17/135 (12%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQ--------FRTREGFYKLLPGDGAARRSGPASAQTPVPP 56
           G +G  G    MG+   IK Q        FR    +Y      G     GP   +    P
Sbjct: 312 GVKGNRGFPGLMGEDG-IKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGP 370

Query: 57  QPPQPPPG-PASASGPGAAGPASSPPPAGPG-PGPALPAVRLSLVRLGEPDSAG-AGEP- 112
           Q P  PPG P S   PG++ P     P  PG  G      R     +G P S G AG P 
Sbjct: 371 QGPSGPPGVPGS---PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPG 427

Query: 113 -PATPAGLGSGGDRV 126
            P +P   G  GD V
Sbjct: 428 LPGSPGPPGPPGDIV 442



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 42/157 (26%), Positives = 50/157 (31%), Gaps = 36/157 (22%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG---------------P 47
           A G +G SGP    G     +   R   G+  L    G   R G               P
Sbjct: 367 ARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSP 426

Query: 48  ASAQTPVPPQPP------QPPPGPASASG-------PGAAGPASSPP------PAGPGPG 88
               +P PP PP      + PPG     G       PG  GP   P       P  PGP 
Sbjct: 427 GLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPP 486

Query: 89  --PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P LP +       G   +AG    P +P   G  G
Sbjct: 487 GLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG 523



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/113 (25%), Positives = 38/113 (33%), Gaps = 6/113 (5%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
            PG PG   PA      G PG   LP        L      G  G PG+   PG P   G 
Sbjct: 1088 PGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGS 1147

Query: 523  FATLTLQERRDR------GAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVP 569
               + ++  + R        EK            RG  G  G+ G++ +   P
Sbjct: 1148 PGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFP 1200



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 38/130 (29%), Positives = 45/130 (34%), Gaps = 22/130 (16%)

Query: 2    AAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A  G  G  G   A GD        R   GF  L    GA   +GP     P   +    
Sbjct: 1177 APPGPRGNPGAQGAKGD--------RGAPGFPGLPGRKGAMGDAGPRG---PTGIEGFPG 1225

Query: 62   PPGPASASGPGAAG----PASSPPPAGPG----PGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPG   A  PG  G    P S   P  PG    PG  +  ++     +G P   G   PP
Sbjct: 1226 PPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKG---PP 1282

Query: 114  ATPAGLGSGG 123
             T   +G  G
Sbjct: 1283 GTAGDMGPPG 1292



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 34/101 (33%), Positives = 37/101 (36%), Gaps = 21/101 (20%)

Query: 43   RRSGPASAQTPVPPQPP--QPPPGPASASG-PGAAGPASSPPPAGPGPGPALPAVR---- 95
            R   P +   P P   P  Q  PG     G PG  G    P P GP  GP  P VR    
Sbjct: 1293 RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGP-KGP--PGVRGDPG 1349

Query: 96   -LSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
             L ++ L          GEP   G   PP  P  LG  G R
Sbjct: 1350 TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPR 1390



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 63  PGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSL-VR--LGEPDSAGAGEPPATPAG 118
           PGP  + G  G  GP   P P GP   P LP +  S  VR   G P  +G+   P TP  
Sbjct: 54  PGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN 113

Query: 119 LGSGG 123
            G  G
Sbjct: 114 TGPYG 118



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 33/120 (27%), Positives = 41/120 (34%), Gaps = 31/120 (25%)

Query: 398 GEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLA 457
           G   + EP   GT    GAP  P           G AG                P   L+
Sbjct: 617 GYGPQGEPGLQGTQGVPGAPGPP-----------GEAG----------------PRGELS 649

Query: 458 RTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            +  +PG PG   P       G  GP  +P SL +      P   G+ G PG+   PG P
Sbjct: 650 VSTPVPGPPG---PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGF-PGPP 705



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 3/67 (4%)

Query: 454  PPLARTRTLPGTPGTTPPAA---SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
            P L   + LPG  G   P     S+   GEPG   +P S+            G  G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 511  AAEPGTP 517
            A  PG P
Sbjct: 1038 AGRPGLP 1044



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 30/105 (28%), Positives = 34/105 (32%), Gaps = 19/105 (18%)

Query: 35   LLPGDGAARRSGPASAQTPVPPQPPQPP----------------PGPASASGPGAAGPAS 78
            ++PG     R  P S  +P  P PP PP                PGP     PG AG   
Sbjct: 1233 IIPGQ-TGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGP--PGTAGDMG 1289

Query: 79   SPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P   G    P LP  R      G P   G    P     +G  G
Sbjct: 1290 PPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPG 1334



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 13/82 (15%)

Query: 53   PVPPQPPQPPPGPASASGPGAAGPASSPPPAGPG-----------PGPALPAVRLSLVRL 101
            P  P PP  P  P     PG  GP  +  P GP            PGPA    + +    
Sbjct: 1357 PGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA--GEKGNKGSK 1414

Query: 102  GEPDSAGAGEPPATPAGLGSGG 123
            GEP  AG+   P      G  G
Sbjct: 1415 GEPGPAGSDGLPGLKGKRGDSG 1436



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 16/96 (16%)

Query: 5   GAEGGSGPGAAMG--DCAEIKSQFRTREGF--------YKLLPGDGAARRSGPASAQTPV 54
           G  G +GP   +G   C+  K +    +GF        Y  +PG    +    A A+   
Sbjct: 109 GTPGNTGPYGLVGVPGCSGSKGE----QGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEED 164

Query: 55  PPQPPQPPPGPASASGP-GAAGPASSPPPAGPGPGP 89
                +  PG   A GP G  GP   P P GP PGP
Sbjct: 165 IELDAKGDPGLPGAPGPQGLPGPPGFPGPVGP-PGP 199



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 26/72 (36%), Positives = 28/72 (38%), Gaps = 2/72 (2%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPG-PG-PLPRSLSRSNSLPHPAGGGKAGGPG 509
           P P  AR    P  P   P +  SSR G  G PG P  +        P     G  G PG
Sbjct: 362 PGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPG 421

Query: 510 VAAEPGTPFSIG 521
            A  PG P S G
Sbjct: 422 CAGSPGLPGSPG 433



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/120 (27%), Positives = 43/120 (35%), Gaps = 27/120 (22%)

Query: 460 RTLPGTPGTT-PPAASSSRG--------GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
           R  PG PG   PP      G        G PGP   P +  +  S   P   G+ G PG 
Sbjct: 873 RGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGG-SGGSGSGGEKPSGPVP 569
             E G                 D+G     +  H +G+    G  G +G+ GEK +  VP
Sbjct: 933 KGEQG-----------------DKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVP 975



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 34/111 (30%), Positives = 39/111 (35%), Gaps = 14/111 (12%)

Query: 460  RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
            R +PG PG           G PGP   P       S  +P   G  G PG     G P S
Sbjct: 972  RGVPGMPGL------KGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGS 1025

Query: 520  IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSG-SGGEKPSGPVP 569
             G+  TL    R  R         H L    +G  G  G S G +P  P P
Sbjct: 1026 KGKRGTLGFPGRAGRPG---LPGIHGL----QGDKGEPGYSEGTRPGPPGP 1069



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 39/150 (26%), Positives = 49/150 (32%), Gaps = 34/150 (22%)

Query: 391 GADGERS--GEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYRFGSAG----------- 435
           G+ GER   G++    P + G   + G P SP P    G I +R G  G           
Sbjct: 401 GSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSP 460

Query: 436 ----------QDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGP 485
                     +    C    T+    P PP      LPG PG         R G  G   
Sbjct: 461 GIPGVDGPKGEPGLLC----TQCPYIPGPP-----GLPGLPGLHGVKGIPGRQGAAGLKG 511

Query: 486 LPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
            P S   +     P   G  G PG+  E G
Sbjct: 512 SPGSPGNTGLPGFPGFPGAQGDPGLKGEKG 541



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 12/130 (9%)

Query: 462  LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
            +PG+ G         R G PG  P    L      P  + G + G PG   +PG P  +G
Sbjct: 1022 MPGSKGKRGTLGFPGRAGRPGL-PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMG 1080

Query: 522  RFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGT 581
            +           +G   +      LG     G+ GS      P  P P   L    + G 
Sbjct: 1081 K-----------KGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGL 1129

Query: 582  ALCPRIHEVP 591
               P I   P
Sbjct: 1130 LGPPGIRGPP 1139



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 35/112 (31%), Positives = 37/112 (33%), Gaps = 5/112 (4%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PGT        R G PG   LP           P   G+ G PG     G P  IG  
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDP 575
                +  R D G  K      S G    G  G  G  GE P  P P   L P
Sbjct: 1340 GPPGV--RGDPGTLKIISLPGSPG--PPGTPGEPGMQGE-PGPPGPPGNLGP 1386



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPL----PRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PG PG+   +    RG    PG       R     +++  P   G AG PG+   PG P
Sbjct: 377 PGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPP 435



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           PG PG     A +  GG   PG  P    R NS  H    G+ G PG+   PGTP + G
Sbjct: 735 PGLPGAKGEPAVAMPGGPGTPG-FPGE--RGNSGEH----GEIGLPGLPGLPGTPGNEG 786



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 18/55 (32%), Positives = 22/55 (40%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            PG  G+  P       G PG    P +L   +    P   G  G PG+  EPG P
Sbjct: 1324 PGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPP 1378


>gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo
           sapiens]
          Length = 1637

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 48/124 (38%), Gaps = 9/124 (7%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVP--PQPPQPP 62
           G+ G +GP    G   + +   +  +G        G A   G  S  TPVP  P PP PP
Sbjct: 605 GSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPP 664

Query: 63  --PGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
             PGP    G PG+ G    P   GP   P +P +       G P   G    P T   L
Sbjct: 665 GHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFP----GPPGPKGDQGFPGTKGSL 720

Query: 120 GSGG 123
           G  G
Sbjct: 721 GCPG 724



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/109 (36%), Positives = 42/109 (38%), Gaps = 19/109 (17%)

Query: 34  KLLPGD-GAARRSGPASAQTPVPPQPPQP-PPGPASASGPGAAGPASSP-------PPAG 84
           K LPG  G    SG    Q P P  P  P  PGPA  +GP   GP   P        P  
Sbjct: 577 KGLPGPKGELALSGEKGDQGP-PGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGA 635

Query: 85  PG-PGPALPAVRLSLVR--------LGEPDSAGAGEPPATPAGLGSGGD 124
           PG PG A P   LS+           G P   G   PP  P  LG  GD
Sbjct: 636 PGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGD 684



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 4/70 (5%)

Query: 454  PPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
            P   +  +LPG+PG  PP      G  GEPGP   P +L        P   GK G PG A
Sbjct: 1348 PGTLKIISLPGSPG--PPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405

Query: 512  AEPGTPFSIG 521
             E G   S G
Sbjct: 1406 GEKGNKGSKG 1415



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 11/131 (8%)

Query: 451  YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRS-----LSRSNSLPHPAGGGKA 505
            +P PP      +PG  G   P  S    G PGP   P S          S+ HP   G  
Sbjct: 1223 FPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHP---GPK 1279

Query: 506  GGPGVAAEPGTPFSIGRFATLTLQ-ERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKP 564
            G PG A + G P  +G   T  L   R D G +         GN    GS G   G   P
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGP-PGPIGP 1338

Query: 565  SGPVPRSRLDP 575
             GP P  R DP
Sbjct: 1339 KGP-PGVRGDP 1348



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 31/78 (39%), Positives = 35/78 (44%), Gaps = 18/78 (23%)

Query: 463 PGTPGTTPPAASSSRG--GEPG----------PGPL----PRS-LSRSNSLPHPAGG-GK 504
           PG+PG   PA     G  GEPG          PGP     PR  LS S  +P P G  G 
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 505 AGGPGVAAEPGTPFSIGR 522
            G PG    PG P S+G+
Sbjct: 664 PGHPGPQGPPGIPGSLGK 681



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 43/135 (31%), Positives = 51/135 (37%), Gaps = 17/135 (12%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQ--------FRTREGFYKLLPGDGAARRSGPASAQTPVPP 56
           G +G  G    MG+   IK Q        FR    +Y      G     GP   +    P
Sbjct: 312 GVKGNRGFPGLMGEDG-IKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGP 370

Query: 57  QPPQPPPG-PASASGPGAAGPASSPPPAGPG-PGPALPAVRLSLVRLGEPDSAG-AGEP- 112
           Q P  PPG P S   PG++ P     P  PG  G      R     +G P S G AG P 
Sbjct: 371 QGPSGPPGVPGS---PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPG 427

Query: 113 -PATPAGLGSGGDRV 126
            P +P   G  GD V
Sbjct: 428 LPGSPGPPGPPGDIV 442



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 42/157 (26%), Positives = 50/157 (31%), Gaps = 36/157 (22%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG---------------P 47
           A G +G SGP    G     +   R   G+  L    G   R G               P
Sbjct: 367 ARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSP 426

Query: 48  ASAQTPVPPQPP------QPPPGPASASG-------PGAAGPASSPP------PAGPGPG 88
               +P PP PP      + PPG     G       PG  GP   P       P  PGP 
Sbjct: 427 GLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPP 486

Query: 89  --PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P LP +       G   +AG    P +P   G  G
Sbjct: 487 GLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG 523



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/113 (25%), Positives = 38/113 (33%), Gaps = 6/113 (5%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
            PG PG   PA      G PG   LP        L      G  G PG+   PG P   G 
Sbjct: 1088 PGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGS 1147

Query: 523  FATLTLQERRDR------GAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVP 569
               + ++  + R        EK            RG  G  G+ G++ +   P
Sbjct: 1148 PGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFP 1200



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 38/130 (29%), Positives = 45/130 (34%), Gaps = 22/130 (16%)

Query: 2    AAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A  G  G  G   A GD        R   GF  L    GA   +GP     P   +    
Sbjct: 1177 APPGPRGNPGAQGAKGD--------RGAPGFPGLPGRKGAMGDAGPRG---PTGIEGFPG 1225

Query: 62   PPGPASASGPGAAG----PASSPPPAGPG----PGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPG   A  PG  G    P S   P  PG    PG  +  ++     +G P   G   PP
Sbjct: 1226 PPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKG---PP 1282

Query: 114  ATPAGLGSGG 123
             T   +G  G
Sbjct: 1283 GTAGDMGPPG 1292



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 34/101 (33%), Positives = 37/101 (36%), Gaps = 21/101 (20%)

Query: 43   RRSGPASAQTPVPPQPP--QPPPGPASASG-PGAAGPASSPPPAGPGPGPALPAVR---- 95
            R   P +   P P   P  Q  PG     G PG  G    P P GP  GP  P VR    
Sbjct: 1293 RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGP-KGP--PGVRGDPG 1349

Query: 96   -LSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
             L ++ L          GEP   G   PP  P  LG  G R
Sbjct: 1350 TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPR 1390



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 63  PGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSL-VR--LGEPDSAGAGEPPATPAG 118
           PGP  + G  G  GP   P P GP   P LP +  S  VR   G P  +G+   P TP  
Sbjct: 54  PGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN 113

Query: 119 LGSGG 123
            G  G
Sbjct: 114 TGPYG 118



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 33/120 (27%), Positives = 41/120 (34%), Gaps = 31/120 (25%)

Query: 398 GEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLA 457
           G   + EP   GT    GAP  P           G AG                P   L+
Sbjct: 617 GYGPQGEPGLQGTQGVPGAPGPP-----------GEAG----------------PRGELS 649

Query: 458 RTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            +  +PG PG   P       G  GP  +P SL +      P   G+ G PG+   PG P
Sbjct: 650 VSTPVPGPPG---PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGF-PGPP 705



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 3/67 (4%)

Query: 454  PPLARTRTLPGTPGTTPPAA---SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
            P L   + LPG  G   P     S+   GEPG   +P S+            G  G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 511  AAEPGTP 517
            A  PG P
Sbjct: 1038 AGRPGLP 1044



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 30/105 (28%), Positives = 34/105 (32%), Gaps = 19/105 (18%)

Query: 35   LLPGDGAARRSGPASAQTPVPPQPPQPP----------------PGPASASGPGAAGPAS 78
            ++PG     R  P S  +P  P PP PP                PGP     PG AG   
Sbjct: 1233 IIPGQ-TGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGP--PGTAGDMG 1289

Query: 79   SPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P   G    P LP  R      G P   G    P     +G  G
Sbjct: 1290 PPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPG 1334



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 13/82 (15%)

Query: 53   PVPPQPPQPPPGPASASGPGAAGPASSPPPAGPG-----------PGPALPAVRLSLVRL 101
            P  P PP  P  P     PG  GP  +  P GP            PGPA    + +    
Sbjct: 1357 PGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA--GEKGNKGSK 1414

Query: 102  GEPDSAGAGEPPATPAGLGSGG 123
            GEP  AG+   P      G  G
Sbjct: 1415 GEPGPAGSDGLPGLKGKRGDSG 1436



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 16/96 (16%)

Query: 5   GAEGGSGPGAAMG--DCAEIKSQFRTREGF--------YKLLPGDGAARRSGPASAQTPV 54
           G  G +GP   +G   C+  K +    +GF        Y  +PG    +    A A+   
Sbjct: 109 GTPGNTGPYGLVGVPGCSGSKGE----QGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEED 164

Query: 55  PPQPPQPPPGPASASGP-GAAGPASSPPPAGPGPGP 89
                +  PG   A GP G  GP   P P GP PGP
Sbjct: 165 IELDAKGDPGLPGAPGPQGLPGPPGFPGPVGP-PGP 199



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 26/72 (36%), Positives = 28/72 (38%), Gaps = 2/72 (2%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPG-PG-PLPRSLSRSNSLPHPAGGGKAGGPG 509
           P P  AR    P  P   P +  SSR G  G PG P  +        P     G  G PG
Sbjct: 362 PGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPG 421

Query: 510 VAAEPGTPFSIG 521
            A  PG P S G
Sbjct: 422 CAGSPGLPGSPG 433



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/120 (27%), Positives = 43/120 (35%), Gaps = 27/120 (22%)

Query: 460 RTLPGTPGTT-PPAASSSRG--------GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
           R  PG PG   PP      G        G PGP   P +  +  S   P   G+ G PG 
Sbjct: 873 RGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGG-SGGSGSGGEKPSGPVP 569
             E G                 D+G     +  H +G+    G  G +G+ GEK +  VP
Sbjct: 933 KGEQG-----------------DKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVP 975



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 34/111 (30%), Positives = 39/111 (35%), Gaps = 14/111 (12%)

Query: 460  RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
            R +PG PG           G PGP   P       S  +P   G  G PG     G P S
Sbjct: 972  RGVPGMPGL------KGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGS 1025

Query: 520  IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSG-SGGEKPSGPVP 569
             G+  TL    R  R         H L    +G  G  G S G +P  P P
Sbjct: 1026 KGKRGTLGFPGRAGRPG---LPGIHGL----QGDKGEPGYSEGTRPGPPGP 1069



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 39/150 (26%), Positives = 49/150 (32%), Gaps = 34/150 (22%)

Query: 391 GADGERS--GEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYRFGSAG----------- 435
           G+ GER   G++    P + G   + G P SP P    G I +R G  G           
Sbjct: 401 GSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSP 460

Query: 436 ----------QDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGP 485
                     +    C    T+    P PP      LPG PG         R G  G   
Sbjct: 461 GIPGVDGPKGEPGLLC----TQCPYIPGPP-----GLPGLPGLHGVKGIPGRQGAAGLKG 511

Query: 486 LPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
            P S   +     P   G  G PG+  E G
Sbjct: 512 SPGSPGNTGLPGFPGFPGAQGDPGLKGEKG 541



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 12/130 (9%)

Query: 462  LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
            +PG+ G         R G PG  P    L      P  + G + G PG   +PG P  +G
Sbjct: 1022 MPGSKGKRGTLGFPGRAGRPGL-PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMG 1080

Query: 522  RFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGT 581
            +           +G   +      LG     G+ GS      P  P P   L    + G 
Sbjct: 1081 K-----------KGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGL 1129

Query: 582  ALCPRIHEVP 591
               P I   P
Sbjct: 1130 LGPPGIRGPP 1139



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 35/112 (31%), Positives = 37/112 (33%), Gaps = 5/112 (4%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PGT        R G PG   LP           P   G+ G PG     G P  IG  
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDP 575
                +  R D G  K      S G    G  G  G  GE P  P P   L P
Sbjct: 1340 GPPGV--RGDPGTLKIISLPGSPG--PPGTPGEPGMQGE-PGPPGPPGNLGP 1386



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPL----PRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PG PG+   +    RG    PG       R     +++  P   G AG PG+   PG P
Sbjct: 377 PGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPP 435



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           PG PG     A +  GG   PG  P    R NS  H    G+ G PG+   PGTP + G
Sbjct: 735 PGLPGAKGEPAVAMPGGPGTPG-FPGE--RGNSGEH----GEIGLPGLPGLPGTPGNEG 786



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 18/55 (32%), Positives = 22/55 (40%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            PG  G+  P       G PG    P +L   +    P   G  G PG+  EPG P
Sbjct: 1324 PGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPP 1378


>gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo
           sapiens]
          Length = 1670

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/124 (31%), Positives = 48/124 (38%), Gaps = 9/124 (7%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVP--PQPPQPP 62
           G+ G +GP    G   + +   +  +G        G A   G  S  TPVP  P PP PP
Sbjct: 605 GSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPP 664

Query: 63  --PGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGL 119
             PGP    G PG+ G    P   GP   P +P +       G P   G    P T   L
Sbjct: 665 GHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFP----GPPGPKGDQGFPGTKGSL 720

Query: 120 GSGG 123
           G  G
Sbjct: 721 GCPG 724



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/109 (36%), Positives = 42/109 (38%), Gaps = 19/109 (17%)

Query: 34  KLLPGD-GAARRSGPASAQTPVPPQPPQP-PPGPASASGPGAAGPASSP-------PPAG 84
           K LPG  G    SG    Q P P  P  P  PGPA  +GP   GP   P        P  
Sbjct: 577 KGLPGPKGELALSGEKGDQGP-PGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGA 635

Query: 85  PG-PGPALPAVRLSLVR--------LGEPDSAGAGEPPATPAGLGSGGD 124
           PG PG A P   LS+           G P   G   PP  P  LG  GD
Sbjct: 636 PGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGD 684



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 4/70 (5%)

Query: 454  PPLARTRTLPGTPGTTPPAASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVA 511
            P   +  +LPG+PG  PP      G  GEPGP   P +L        P   GK G PG A
Sbjct: 1348 PGTLKIISLPGSPG--PPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405

Query: 512  AEPGTPFSIG 521
             E G   S G
Sbjct: 1406 GEKGNKGSKG 1415



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/131 (32%), Positives = 49/131 (37%), Gaps = 11/131 (8%)

Query: 451  YPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRS-----LSRSNSLPHPAGGGKA 505
            +P PP      +PG  G   P  S    G PGP   P S          S+ HP   G  
Sbjct: 1223 FPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHP---GPK 1279

Query: 506  GGPGVAAEPGTPFSIGRFATLTLQ-ERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKP 564
            G PG A + G P  +G   T  L   R D G +         GN    GS G   G   P
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGP-PGPIGP 1338

Query: 565  SGPVPRSRLDP 575
             GP P  R DP
Sbjct: 1339 KGP-PGVRGDP 1348



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 31/78 (39%), Positives = 35/78 (44%), Gaps = 18/78 (23%)

Query: 463 PGTPGTTPPAASSSRG--GEPG----------PGPL----PRS-LSRSNSLPHPAGG-GK 504
           PG+PG   PA     G  GEPG          PGP     PR  LS S  +P P G  G 
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 505 AGGPGVAAEPGTPFSIGR 522
            G PG    PG P S+G+
Sbjct: 664 PGHPGPQGPPGIPGSLGK 681



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 43/135 (31%), Positives = 51/135 (37%), Gaps = 17/135 (12%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQ--------FRTREGFYKLLPGDGAARRSGPASAQTPVPP 56
           G +G  G    MG+   IK Q        FR    +Y      G     GP   +    P
Sbjct: 312 GVKGNRGFPGLMGEDG-IKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGP 370

Query: 57  QPPQPPPG-PASASGPGAAGPASSPPPAGPG-PGPALPAVRLSLVRLGEPDSAG-AGEP- 112
           Q P  PPG P S   PG++ P     P  PG  G      R     +G P S G AG P 
Sbjct: 371 QGPSGPPGVPGS---PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPG 427

Query: 113 -PATPAGLGSGGDRV 126
            P +P   G  GD V
Sbjct: 428 LPGSPGPPGPPGDIV 442



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 42/157 (26%), Positives = 50/157 (31%), Gaps = 36/157 (22%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSG---------------P 47
           A G +G SGP    G     +   R   G+  L    G   R G               P
Sbjct: 367 ARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSP 426

Query: 48  ASAQTPVPPQPP------QPPPGPASASG-------PGAAGPASSPP------PAGPGPG 88
               +P PP PP      + PPG     G       PG  GP   P       P  PGP 
Sbjct: 427 GLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPP 486

Query: 89  --PALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P LP +       G   +AG    P +P   G  G
Sbjct: 487 GLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG 523



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/113 (25%), Positives = 38/113 (33%), Gaps = 6/113 (5%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGR 522
            PG PG   PA      G PG   LP        L      G  G PG+   PG P   G 
Sbjct: 1088 PGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGS 1147

Query: 523  FATLTLQERRDR------GAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVP 569
               + ++  + R        EK            RG  G  G+ G++ +   P
Sbjct: 1148 PGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFP 1200



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 38/130 (29%), Positives = 45/130 (34%), Gaps = 22/130 (16%)

Query: 2    AAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A  G  G  G   A GD        R   GF  L    GA   +GP     P   +    
Sbjct: 1177 APPGPRGNPGAQGAKGD--------RGAPGFPGLPGRKGAMGDAGPRG---PTGIEGFPG 1225

Query: 62   PPGPASASGPGAAG----PASSPPPAGPG----PGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPG   A  PG  G    P S   P  PG    PG  +  ++     +G P   G   PP
Sbjct: 1226 PPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKG---PP 1282

Query: 114  ATPAGLGSGG 123
             T   +G  G
Sbjct: 1283 GTAGDMGPPG 1292



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 34/101 (33%), Positives = 37/101 (36%), Gaps = 21/101 (20%)

Query: 43   RRSGPASAQTPVPPQPP--QPPPGPASASG-PGAAGPASSPPPAGPGPGPALPAVR---- 95
            R   P +   P P   P  Q  PG     G PG  G    P P GP  GP  P VR    
Sbjct: 1293 RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGP-KGP--PGVRGDPG 1349

Query: 96   -LSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
             L ++ L          GEP   G   PP  P  LG  G R
Sbjct: 1350 TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPR 1390



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 63  PGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSL-VR--LGEPDSAGAGEPPATPAG 118
           PGP  + G  G  GP   P P GP   P LP +  S  VR   G P  +G+   P TP  
Sbjct: 54  PGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN 113

Query: 119 LGSGG 123
            G  G
Sbjct: 114 TGPYG 118



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 33/120 (27%), Positives = 41/120 (34%), Gaps = 31/120 (25%)

Query: 398 GEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLA 457
           G   + EP   GT    GAP  P           G AG                P   L+
Sbjct: 617 GYGPQGEPGLQGTQGVPGAPGPP-----------GEAG----------------PRGELS 649

Query: 458 RTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            +  +PG PG   P       G  GP  +P SL +      P   G+ G PG+   PG P
Sbjct: 650 VSTPVPGPPG---PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGF-PGPP 705



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 3/67 (4%)

Query: 454  PPLARTRTLPGTPGTTPPAA---SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
            P L   + LPG  G   P     S+   GEPG   +P S+            G  G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 511  AAEPGTP 517
            A  PG P
Sbjct: 1038 AGRPGLP 1044



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 30/105 (28%), Positives = 34/105 (32%), Gaps = 19/105 (18%)

Query: 35   LLPGDGAARRSGPASAQTPVPPQPPQPP----------------PGPASASGPGAAGPAS 78
            ++PG     R  P S  +P  P PP PP                PGP     PG AG   
Sbjct: 1233 IIPGQ-TGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGP--PGTAGDMG 1289

Query: 79   SPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
             P   G    P LP  R      G P   G    P     +G  G
Sbjct: 1290 PPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPG 1334



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 25/82 (30%), Positives = 29/82 (35%), Gaps = 13/82 (15%)

Query: 53   PVPPQPPQPPPGPASASGPGAAGPASSPPPAGPG-----------PGPALPAVRLSLVRL 101
            P  P PP  P  P     PG  GP  +  P GP            PGPA    + +    
Sbjct: 1357 PGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA--GEKGNKGSK 1414

Query: 102  GEPDSAGAGEPPATPAGLGSGG 123
            GEP  AG+   P      G  G
Sbjct: 1415 GEPGPAGSDGLPGLKGKRGDSG 1436



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 16/96 (16%)

Query: 5   GAEGGSGPGAAMG--DCAEIKSQFRTREGF--------YKLLPGDGAARRSGPASAQTPV 54
           G  G +GP   +G   C+  K +    +GF        Y  +PG    +    A A+   
Sbjct: 109 GTPGNTGPYGLVGVPGCSGSKGE----QGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEED 164

Query: 55  PPQPPQPPPGPASASGP-GAAGPASSPPPAGPGPGP 89
                +  PG   A GP G  GP   P P GP PGP
Sbjct: 165 IELDAKGDPGLPGAPGPQGLPGPPGFPGPVGP-PGP 199



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 26/72 (36%), Positives = 28/72 (38%), Gaps = 2/72 (2%)

Query: 452 PHPPLARTRTLPGTPGTTPPAASSSRGGEPG-PG-PLPRSLSRSNSLPHPAGGGKAGGPG 509
           P P  AR    P  P   P +  SSR G  G PG P  +        P     G  G PG
Sbjct: 362 PGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPG 421

Query: 510 VAAEPGTPFSIG 521
            A  PG P S G
Sbjct: 422 CAGSPGLPGSPG 433



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 33/120 (27%), Positives = 43/120 (35%), Gaps = 27/120 (22%)

Query: 460 RTLPGTPGTT-PPAASSSRG--------GEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGV 510
           R  PG PG   PP      G        G PGP   P +  +  S   P   G+ G PG 
Sbjct: 873 RGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGG-SGGSGSGGEKPSGPVP 569
             E G                 D+G     +  H +G+    G  G +G+ GEK +  VP
Sbjct: 933 KGEQG-----------------DKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVP 975



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 34/111 (30%), Positives = 39/111 (35%), Gaps = 14/111 (12%)

Query: 460  RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
            R +PG PG           G PGP   P       S  +P   G  G PG     G P S
Sbjct: 972  RGVPGMPGL------KGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGS 1025

Query: 520  IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSG-SGGEKPSGPVP 569
             G+  TL    R  R         H L    +G  G  G S G +P  P P
Sbjct: 1026 KGKRGTLGFPGRAGRPG---LPGIHGL----QGDKGEPGYSEGTRPGPPGP 1069



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 39/150 (26%), Positives = 49/150 (32%), Gaps = 34/150 (22%)

Query: 391 GADGERS--GEEEEEEPEAAGTGSAGGAPLSPLPKA--GSITYRFGSAG----------- 435
           G+ GER   G++    P + G   + G P SP P    G I +R G  G           
Sbjct: 401 GSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSP 460

Query: 436 ----------QDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGP 485
                     +    C    T+    P PP      LPG PG         R G  G   
Sbjct: 461 GIPGVDGPKGEPGLLC----TQCPYIPGPP-----GLPGLPGLHGVKGIPGRQGAAGLKG 511

Query: 486 LPRSLSRSNSLPHPAGGGKAGGPGVAAEPG 515
            P S   +     P   G  G PG+  E G
Sbjct: 512 SPGSPGNTGLPGFPGFPGAQGDPGLKGEKG 541



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 12/130 (9%)

Query: 462  LPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
            +PG+ G         R G PG  P    L      P  + G + G PG   +PG P  +G
Sbjct: 1022 MPGSKGKRGTLGFPGRAGRPGL-PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMG 1080

Query: 522  RFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGT 581
            +           +G   +      LG     G+ GS      P  P P   L    + G 
Sbjct: 1081 K-----------KGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGL 1129

Query: 582  ALCPRIHEVP 591
               P I   P
Sbjct: 1130 LGPPGIRGPP 1139



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 35/112 (31%), Positives = 37/112 (33%), Gaps = 5/112 (4%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PGT        R G PG   LP           P   G+ G PG     G P  IG  
Sbjct: 1280 GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDP 575
                +  R D G  K      S G    G  G  G  GE P  P P   L P
Sbjct: 1340 GPPGV--RGDPGTLKIISLPGSPG--PPGTPGEPGMQGE-PGPPGPPGNLGP 1386



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPL----PRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PG PG+   +    RG    PG       R     +++  P   G AG PG+   PG P
Sbjct: 377 PGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPP 435



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIG 521
           PG PG     A +  GG   PG  P    R NS  H    G+ G PG+   PGTP + G
Sbjct: 735 PGLPGAKGEPAVAMPGGPGTPG-FPGE--RGNSGEH----GEIGLPGLPGLPGTPGNEG 786



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 18/55 (32%), Positives = 22/55 (40%)

Query: 463  PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
            PG  G+  P       G PG    P +L   +    P   G  G PG+  EPG P
Sbjct: 1324 PGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPP 1378


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 40/132 (30%), Positives = 47/132 (35%), Gaps = 23/132 (17%)

Query: 3    AGGAEGGSGPGAAMGDCAEIKSQ-FRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A G +G  GP    G+  E   +  +   GF  L    G    SG   A  P  P  P+ 
Sbjct: 1105 ARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRG 1164

Query: 62   PPGPASASG-------------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAG 108
            PPGP   SG             PG  G +    PAGP   P  P         G P   G
Sbjct: 1165 PPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPP---------GPPGPPG 1215

Query: 109  AGEPPATPAGLG 120
             G   +  AGLG
Sbjct: 1216 PGIDMSAFAGLG 1227



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 30/86 (34%), Positives = 34/86 (39%), Gaps = 8/86 (9%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLV 99
           G A + G A A  P  P     P GP   +GP  A  A  PP A   PG A         
Sbjct: 852 GEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAA--------G 903

Query: 100 RLGEPDSAGAGEPPATPAGLGSGGDR 125
           R+G P S G   PP  P   G  G +
Sbjct: 904 RVGPPGSNGNPGPPGPPGPSGKDGPK 929



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 44/141 (31%), Positives = 49/141 (34%), Gaps = 24/141 (17%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQ--TPVPPQP-PQ 60
           G  G  GP  A G   E  +            PG DG     G A A      P  P P+
Sbjct: 378 GPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPR 437

Query: 61  PPPGPASASGP----------------GAAGPASSPPPAGP--GPGPALPAVRLSLVRLG 102
            PPGP  A+GP                G  GP   P PAGP   PGPA    +      G
Sbjct: 438 GPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRG--ARG 495

Query: 103 EPDSAGAGEPPATPAGLGSGG 123
           EP   G   PP      G+ G
Sbjct: 496 EPGGVGPIGPPGERGAPGNRG 516



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/80 (33%), Positives = 30/80 (37%), Gaps = 7/80 (8%)

Query: 51  QTPVPPQPPQPPPGPASASG-------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGE 103
           Q P+ P  P+ PPGPA A G       PG  G      P GP   P  P         G+
Sbjct: 200 QGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGK 259

Query: 104 PDSAGAGEPPATPAGLGSGG 123
           P  AG   PP      G  G
Sbjct: 260 PGKAGERGPPGPQGARGFPG 279



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/123 (26%), Positives = 43/123 (34%), Gaps = 2/123 (1%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGA--ARRSGPASAQTPVPPQPPQPP 62
            GAEG  GP    G    +    +  E  +  LPG      ++  P ++    PP P  PP
Sbjct: 966  GAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPP 1025

Query: 63   PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSG 122
                 A  PG  G   +  P G      +   R     +G P + G    P      G  
Sbjct: 1026 GLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQ 1085

Query: 123  GDR 125
            GDR
Sbjct: 1086 GDR 1088



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 43/120 (35%), Positives = 45/120 (37%), Gaps = 33/120 (27%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           GA G  GP  A G                   PG  A R   P S   P PP PP    G
Sbjct: 885 GARGAQGPPGATG------------------FPG-AAGRVGPPGSNGNPGPPGPP----G 921

Query: 65  PASASGP-GAAGPASSPPPAG-PG-PGPALPAVRLSLVRLGEP--DSAGAGEPPATPAGL 119
           P+   GP GA G +  P  AG PG  GPA P         GEP  D     E P  P GL
Sbjct: 922 PSGKDGPKGARGDSGPPGRAGEPGLQGPAGPP-----GEKGEPGDDGPSGAEGPPGPQGL 976



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 38/113 (33%), Positives = 43/113 (38%), Gaps = 24/113 (21%)

Query: 464 GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG----GGKAGGPGVAAEPGTPFS 519
           G PG   PA      G PGP       S    LP P G    GGK G  GV  E G P  
Sbjct: 642 GPPGPAGPAGERGEQGAPGP-------SGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL 694

Query: 520 IGRFATLTLQERRDRGAEKEHKRYHSLG-NISRGGSGGSGSGGEK----PSGP 567
           +G         R +RG   E     + G    RG  G  G+ G K    P+GP
Sbjct: 695 VG--------PRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGP 739



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 39/130 (30%), Positives = 47/130 (36%), Gaps = 20/130 (15%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQTPVPPQPPQP-- 61
           GA G +GP    GD  E     +  EG     PG DG    +GP     P      +   
Sbjct: 756 GAAGIAGPKGDRGDVGE-----KGPEG----APGKDGGRGLTGPIGPPGPAGANGEKGEV 806

Query: 62  -PPGPASASG----PGAAGPASSPPP---AGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPGPA ++G    PG  G    P P   AGP      P  +      G+   AGA  P 
Sbjct: 807 GPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQ 866

Query: 114 ATPAGLGSGG 123
                 G  G
Sbjct: 867 GPSGAPGPQG 876



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 39/119 (32%), Positives = 45/119 (37%), Gaps = 20/119 (16%)

Query: 463 PGTPGTTPPAASSSRGGEPGP-GPL-PRSLSRSNSLPHPAGG----------GKAGGPGV 510
           PG PG    A    + GE GP GP   R    +  LP   G           G+AG PGV
Sbjct: 248 PGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGV 307

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNI-SRGGSGGSGSGGEKPSGPV 568
             E G+P   G    +       RG   E  R    G   +RG  G  G  G  P GPV
Sbjct: 308 KGESGSPGENGSPGPM-----GPRGLPGERGRTGPAGAAGARGNDGQPGPAG--PPGPV 359



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 29/104 (27%), Positives = 36/104 (34%), Gaps = 19/104 (18%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGPASASGP----------GAAGPASSPPPAGPGPGP 89
           G    SG         P  P+  PG    +GP          G  GPA  P P GP  GP
Sbjct: 306 GVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP 365

Query: 90  ALPAVRLSLVRLGEPDSAG-------AGEP--PATPAGLGSGGD 124
             P    +    G   + G        GEP  P +P   G+ G+
Sbjct: 366 GFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGN 409



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 35/123 (28%), Positives = 38/123 (30%), Gaps = 13/123 (10%)

Query: 1   MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQ 60
           M   G  G  GP  A G            +GF       G    SGP   + P  P PP 
Sbjct: 203 MGPMGPRGPPGPAGAPGP-----------QGFQGNPGEPGEPGVSGPMGPRGP--PGPPG 249

Query: 61  PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
            P     A  PG AG    P P G    P  P +       G P   GA      P   G
Sbjct: 250 KPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKG 309

Query: 121 SGG 123
             G
Sbjct: 310 ESG 312



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 39/128 (30%), Positives = 42/128 (32%), Gaps = 31/128 (24%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G+ G  GP    G+        R R G     P   A  R          PP P  P  G
Sbjct: 318 GSPGPMGPRGLPGE--------RGRTG-----PAGAAGARGNDGQPGPAGPPGPVGPAGG 364

Query: 65  PASASGPGA---AGPASSPPP---AGPGPGPALPAVRLSLVRLGEPDSAGAGEPPAT--- 115
           P     PGA   AGP  +  P    GP   P  P         G P  AGA   P T   
Sbjct: 365 PGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTP---------GSPGPAGASGNPGTDGI 415

Query: 116 PAGLGSGG 123
           P   GS G
Sbjct: 416 PGAKGSAG 423



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 42/127 (33%), Positives = 48/127 (37%), Gaps = 22/127 (17%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPP-----QPP 59
           G  G +GP  A GD          R G   L    G   R G A  Q  V P     +  
Sbjct: 534 GPSGLAGPKGANGDPG--------RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDG 585

Query: 60  QP-PPGPASASG-------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGE 111
           +P PPGP  A G       PG  G    P  AG    P  P +R    + GE  +AG   
Sbjct: 586 RPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP-P 644

Query: 112 PPATPAG 118
            PA PAG
Sbjct: 645 GPAGPAG 651



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 32/109 (29%), Positives = 39/109 (35%), Gaps = 4/109 (3%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PG T PA    R G PG    P     +         G  G PG    PG+P   G  
Sbjct: 1023 GPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAG-- 1080

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSR 572
             T    +R + GA+         G  +RG  G  G  G+K     P  R
Sbjct: 1081 PTGKQGDRGEAGAQGPMGPSGPAG--ARGIQGPQGPRGDKGEAGEPGER 1127



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 56/200 (28%), Positives = 67/200 (33%), Gaps = 28/200 (14%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGG----APLSPLPKAGSITYRFGSAGQDTQFC 441
           AA  AG  G+R G+  E+ PE A  G  GG     P+ P   AG+     G  G+     
Sbjct: 757 AAGIAGPKGDR-GDVGEKGPEGA-PGKDGGRGLTGPIGPPGPAGAN----GEKGE----- 805

Query: 442 LWDLTEDVLYPHPP-LARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPA 500
                  V  P P   A  R  PG  G T P   +   G PG    P +           
Sbjct: 806 -------VGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQK- 857

Query: 501 GGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSG 560
             G AG PG     G P   G   T     +  RGA+         G   R G  GS   
Sbjct: 858 --GDAGAPGPQGPSGAPGPQG--PTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGN 913

Query: 561 GEKPSGPVPRSRLDPAKVLG 580
              P  P P  +  P    G
Sbjct: 914 PGPPGPPGPSGKDGPKGARG 933



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 34/114 (29%), Positives = 41/114 (35%), Gaps = 20/114 (17%)

Query: 12  PGAAMGDCAEI-KSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASG 70
           P    G+C  I  +   T  G     PG    ++  P   +  V P+ P  P GPA   G
Sbjct: 78  PEIPFGECCPICPTDLATASG----QPGP-KGQKGEPGDIKDIVGPKGPPGPQGPAGEQG 132

Query: 71  P----GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
           P    G  G   +P P G    P  P         G P   G   PP  P GLG
Sbjct: 133 PRGDRGDKGEKGAPGPRGRDGEPGTP---------GNPGPPGPPGPPG-PPGLG 176



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 21/55 (38%), Positives = 25/55 (45%), Gaps = 15/55 (27%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PGTPG+  PA +S   G PG   +            P   G AG PG+A  PG P
Sbjct: 395 PGTPGSPGPAGAS---GNPGTDGI------------PGAKGSAGAPGIAGAPGFP 434



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 23/112 (20%)

Query: 460 RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
           R LPGTPGT  P  +S   G PG    P        +P     G+ G  G+A   G    
Sbjct: 719 RGLPGTPGTDGPKGASGPAGPPGAQGPP----GLQGMP-----GERGAAGIAGPKGDRGD 769

Query: 520 IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEK----PSGP 567
           +G        E+   GA  +       G I  G  G +G+ GEK    P GP
Sbjct: 770 VG--------EKGPEGAPGKDGGRGLTGPI--GPPGPAGANGEKGEVGPPGP 811



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 49/161 (30%), Positives = 56/161 (34%), Gaps = 50/161 (31%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQTPVPPQPPQP 61
           A G +G  GP    G             GF    PG  GA   +GP  A+ P   Q P+ 
Sbjct: 343 ARGNDGQPGPAGPPGPVGPAGGP-----GF----PGAPGAKGEAGPTGARGPEGAQGPRG 393

Query: 62  PPG------PASASG-------PGAAGPASSPPPAG----------PGP----GPALPAV 94
            PG      PA ASG       PGA G A +P  AG          PGP    GP  P  
Sbjct: 394 EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKG 453

Query: 95  RLSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
           +     +          GEP  AG   P   P   G  G R
Sbjct: 454 QTGEPGIAGFKGEQGPKGEPGPAG---PQGAPGPAGEEGKR 491



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 58/193 (30%), Positives = 62/193 (32%), Gaps = 44/193 (22%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDL 445
           +A A GA GER    E   P  AG     GA   P  K        G AGQ         
Sbjct: 814 SAGARGAPGERG---ETGPPGPAGFAGPPGADGQPGAKGEQ-----GEAGQKG------- 858

Query: 446 TEDVLYPHPPLARTRTLP-GTPGTTPPAASSSRGGEPGPGPLPRSLSR-----SNSLPHP 499
             D   P P        P G  G T P  +    G PG    P +  R     SN  P P
Sbjct: 859 --DAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGP 916

Query: 500 AG----GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSG 555
            G     GK G  G   + G P   GR     LQ       EK             G  G
Sbjct: 917 PGPPGPSGKDGPKGARGDSGPP---GRAGEPGLQGPAGPPGEK-------------GEPG 960

Query: 556 GSG-SGGEKPSGP 567
             G SG E P GP
Sbjct: 961 DDGPSGAEGPPGP 973



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 46/176 (26%), Positives = 60/176 (34%), Gaps = 16/176 (9%)

Query: 357  EGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGA 416
            EG   A G   +     V  D   T A  A  A G  G         +    G   A G 
Sbjct: 1037 EGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQG- 1095

Query: 417  PLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSS 476
            P+ P   AG+   +     +  +    +  E  L  H      + LPG PG +    +S 
Sbjct: 1096 PMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASG 1155

Query: 477  RGGEPGP----GPL-PRSLSRSNSLPHPAGG----------GKAGGPGVAAEPGTP 517
              G  GP    GP+ P     +N +P P G           G AG PG    PG P
Sbjct: 1156 PAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPP 1211



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 29/77 (37%), Positives = 34/77 (44%), Gaps = 15/77 (19%)

Query: 460 RTLPGTPGTTPPA-ASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAG--------GP 508
           R LPG  G T PA A+ +RG  G+PGP   P  +  +     P   G  G        GP
Sbjct: 326 RGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGP 385

Query: 509 ----GVAAEPGTPFSIG 521
               G   EPGTP S G
Sbjct: 386 EGAQGPRGEPGTPGSPG 402



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 21/68 (30%), Positives = 25/68 (36%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PG   P+      G PGP   P    RS         G  G PG    PG    +  F
Sbjct: 1164 GPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAF 1223

Query: 524  ATLTLQER 531
            A L  +E+
Sbjct: 1224 AGLGPREK 1231



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 39/134 (29%), Positives = 43/134 (32%), Gaps = 15/134 (11%)

Query: 383 AEEAATAAGADGERSGEEEEEEPEAAGT-GSAGGAPLSPLPKAGSITYRFGSAGQDTQFC 441
           A  A   AG  G R  E  +      GT GS G A  S  P    I    GSAG      
Sbjct: 370 APGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPG--- 426

Query: 442 LWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG 501
                   +   P     R  PG  G T P     + GEPG   +            P  
Sbjct: 427 --------IAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPG---IAGFKGEQGPKGEPGP 475

Query: 502 GGKAGGPGVAAEPG 515
            G  G PG A E G
Sbjct: 476 AGPQGAPGPAGEEG 489



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 5/67 (7%)

Query: 453 HPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG----GKAGGP 508
           +P L   +   G PG    + S    G PGP   PR L        PAG     G  G P
Sbjct: 292 YPGLDGAKGEAGAPGVKGESGSPGENGSPGPMG-PRGLPGERGRTGPAGAAGARGNDGQP 350

Query: 509 GVAAEPG 515
           G A  PG
Sbjct: 351 GPAGPPG 357



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 37/138 (26%), Positives = 45/138 (32%), Gaps = 23/138 (16%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD----GAARRSGPASAQ-------TP 53
           G  G  GP  A G+  +   +        + LPG     GAA   GPA           P
Sbjct: 600 GVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAP 659

Query: 54  VP------PQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSA 107
            P      P PP PP         G  G A +P   GP      P  R      G P + 
Sbjct: 660 GPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGER------GSPGAQ 713

Query: 108 GAGEPPATPAGLGSGGDR 125
           G   P   P   G+ G +
Sbjct: 714 GLQGPRGLPGTPGTDGPK 731



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 25/74 (33%), Positives = 28/74 (37%), Gaps = 6/74 (8%)

Query: 454 PPLARTRTLPGTPGTTPPAASSSRGGEPG----PGPLPRSLSRSNS--LPHPAGGGKAGG 507
           P L   R L G PG   P       G PG    PGP     +R     +  P   G  G 
Sbjct: 554 PGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGE 613

Query: 508 PGVAAEPGTPFSIG 521
           PG A E G P + G
Sbjct: 614 PGKAGEKGLPGAPG 627



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 32/124 (25%), Positives = 43/124 (34%), Gaps = 14/124 (11%)

Query: 6   AEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPP--- 62
           A G  GP    G+  +IK           ++   G     GPA  Q P   +  +     
Sbjct: 96  ASGQPGPKGQKGEPGDIKD----------IVGPKGPPGPQGPAGEQGPRGDRGDKGEKGA 145

Query: 63  PGPASASG-PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGS 121
           PGP    G PG  G    P P GP   P L     + +  G  + AG  +       +G 
Sbjct: 146 PGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGP 205

Query: 122 GGDR 125
            G R
Sbjct: 206 MGPR 209



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/97 (30%), Positives = 32/97 (32%), Gaps = 13/97 (13%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPG----PASASGPGAAGPASSPPPA---GPGPGPALP 92
           G     GP  A  P  P   Q PPG    P      G AGP          GP   P   
Sbjct: 723 GTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKD 782

Query: 93  AVRLSLVRLGEPDSAGA-GE-----PPATPAGLGSGG 123
             R     +G P  AGA GE     PP      G+ G
Sbjct: 783 GGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARG 819



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 26/82 (31%), Positives = 30/82 (36%), Gaps = 24/82 (29%)

Query: 464  GTPGTTPPAASSSRGGEPG----------PGP-----------LPRSLSRSN--SLPHPA 500
            G PG   PA      GEPG          PGP           LP          LP P+
Sbjct: 942  GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 1001

Query: 501  GG-GKAGGPGVAAEPGTPFSIG 521
            G  GK G PG + + G P  +G
Sbjct: 1002 GEPGKQGAPGASGDRGPPGPVG 1023



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 38/139 (27%), Positives = 48/139 (34%), Gaps = 14/139 (10%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSP----LPKAGSITYRFGSAGQDTQFCLWDLT 446
           G  G +    E      AG   A G P  P    LP A  +T R G AG   +       
Sbjct: 522 GLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAP 581

Query: 447 EDVLYPHPPLAR-TRTLPGTPGTTPPAASSSRGGEPG----PGP-----LPRSLSRSNSL 496
            +   P PP  +  R  PG  G   P  ++   G+ G    PG      LP     + + 
Sbjct: 582 GEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAA 641

Query: 497 PHPAGGGKAGGPGVAAEPG 515
             P   G AG  G    PG
Sbjct: 642 GPPGPAGPAGERGEQGAPG 660



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 22/68 (32%), Positives = 27/68 (39%), Gaps = 10/68 (14%)

Query: 57  QPPQPPPGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPAT 115
           Q P+  PG     GP GA+GPA  P   GP     +P         GE  +AG   P   
Sbjct: 716 QGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMP---------GERGAAGIAGPKGD 766

Query: 116 PAGLGSGG 123
              +G  G
Sbjct: 767 RGDVGEKG 774



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 54/216 (25%), Positives = 64/216 (29%), Gaps = 43/216 (19%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVL 450
           GA G R  + E   P   G     G P  P           G   +        + +  +
Sbjct: 144 GAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPM 203

Query: 451 YPHPPLARTRTLPGTPGTTPPAASSSRGGEPG-------------PGPLPRSLSRSNSLP 497
            P  P    R  PG  G   P       GEPG             PGP P          
Sbjct: 204 GPMGP----RGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGP-PGKPGDDGEAG 258

Query: 498 HPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNI-----SRG 552
            P   G+ G PG     G P + G                K H+ Y  L        + G
Sbjct: 259 KPGKAGERGPPGPQGARGFPGTPG------------LPGVKGHRGYPGLDGAKGEAGAPG 306

Query: 553 GSGGSGSGGEK----PSGP--VP--RSRLDPAKVLG 580
             G SGS GE     P GP  +P  R R  PA   G
Sbjct: 307 VKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAG 342



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 2/50 (4%)

Query: 40   GAARRSGPASAQTPVPPQPPQPPPGPASASGP-GAAGPASSPPPAGP-GP 87
            GA    GP  +  P  P   Q   G A A GP G +GPA +    GP GP
Sbjct: 1065 GAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGP 1114



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 41/136 (30%), Positives = 51/136 (37%), Gaps = 14/136 (10%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSP--LPKAGSITYRFGSAGQDTQFCLWDLTED 448
           GA GE      + E  + G   + G P+ P  LP     T   G+AG        D    
Sbjct: 297 GAKGEAGAPGVKGESGSPGENGSPG-PMGPRGLPGERGRTGPAGAAGARGN----DGQPG 351

Query: 449 VLYPHPPL--ARTRTLPGTPGTTPPAA-SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKA 505
              P  P+  A     PG PG    A  + +RG E   GP  R    +   P PAG   +
Sbjct: 352 PAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGP--RGEPGTPGSPGPAGA--S 407

Query: 506 GGPGVAAEPGTPFSIG 521
           G PG    PG   S G
Sbjct: 408 GNPGTDGIPGAKGSAG 423



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 41/149 (27%), Positives = 49/149 (32%), Gaps = 31/149 (20%)

Query: 5   GAEGGSGPGAAMGDCAEIK-SQFRTREGFYKLLPGD-------GAARRSGPASAQTPVPP 56
           G +G +GP    G   E   + F+  +G  K  PG        G A   G   A+     
Sbjct: 441 GPQGATGPLGPKGQTGEPGIAGFKGEQG-PKGEPGPAGPQGAPGPAGEEGKRGARGEPGG 499

Query: 57  QPPQPPPGPASASG-------PGAAGPASSPPPAGPG-----------PG----PALPAV 94
             P  PPG   A G        G AGP  +P   GP            PG    P LP  
Sbjct: 500 VGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGA 559

Query: 95  RLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
           R    R G+    G   P   P   G  G
Sbjct: 560 RGLTGRPGDAGPQGKVGPSGAPGEDGRPG 588



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 34/98 (34%), Positives = 37/98 (37%), Gaps = 23/98 (23%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQ----------TP 53
            G  G  GP    G   E       REG     PG DG   R G A  +           P
Sbjct: 1017 GPPGPVGPPGLTGPAGE-----PGREGS----PGADGPPGRDGAAGVKGDRGETGAVGAP 1067

Query: 54   VPPQPPQPPPGPASASG-PGAAGPASSPPPAGPGPGPA 90
              P PP   PGPA  +G  G  G A +  P GP  GPA
Sbjct: 1068 GAPGPP-GSPGPAGPTGKQGDRGEAGAQGPMGPS-GPA 1103


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
            sapiens]
          Length = 1418

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 40/132 (30%), Positives = 47/132 (35%), Gaps = 23/132 (17%)

Query: 3    AGGAEGGSGPGAAMGDCAEIKSQ-FRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQP 61
            A G +G  GP    G+  E   +  +   GF  L    G    SG   A  P  P  P+ 
Sbjct: 1036 ARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRG 1095

Query: 62   PPGPASASG-------------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAG 108
            PPGP   SG             PG  G +    PAGP   P  P         G P   G
Sbjct: 1096 PPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPP---------GPPGPPG 1146

Query: 109  AGEPPATPAGLG 120
             G   +  AGLG
Sbjct: 1147 PGIDMSAFAGLG 1158



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 30/86 (34%), Positives = 34/86 (39%), Gaps = 8/86 (9%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLV 99
           G A + G A A  P  P     P GP   +GP  A  A  PP A   PG A         
Sbjct: 783 GEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAA--------G 834

Query: 100 RLGEPDSAGAGEPPATPAGLGSGGDR 125
           R+G P S G   PP  P   G  G +
Sbjct: 835 RVGPPGSNGNPGPPGPPGPSGKDGPK 860



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 44/141 (31%), Positives = 49/141 (34%), Gaps = 24/141 (17%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQ--TPVPPQP-PQ 60
           G  G  GP  A G   E  +            PG DG     G A A      P  P P+
Sbjct: 309 GPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPR 368

Query: 61  PPPGPASASGP----------------GAAGPASSPPPAGP--GPGPALPAVRLSLVRLG 102
            PPGP  A+GP                G  GP   P PAGP   PGPA    +      G
Sbjct: 369 GPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRG--ARG 426

Query: 103 EPDSAGAGEPPATPAGLGSGG 123
           EP   G   PP      G+ G
Sbjct: 427 EPGGVGPIGPPGERGAPGNRG 447



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/80 (33%), Positives = 30/80 (37%), Gaps = 7/80 (8%)

Query: 51  QTPVPPQPPQPPPGPASASG-------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGE 103
           Q P+ P  P+ PPGPA A G       PG  G      P GP   P  P         G+
Sbjct: 131 QGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGK 190

Query: 104 PDSAGAGEPPATPAGLGSGG 123
           P  AG   PP      G  G
Sbjct: 191 PGKAGERGPPGPQGARGFPG 210



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/123 (26%), Positives = 43/123 (34%), Gaps = 2/123 (1%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGA--ARRSGPASAQTPVPPQPPQPP 62
            GAEG  GP    G    +    +  E  +  LPG      ++  P ++    PP P  PP
Sbjct: 897  GAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPP 956

Query: 63   PGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSG 122
                 A  PG  G   +  P G      +   R     +G P + G    P      G  
Sbjct: 957  GLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQ 1016

Query: 123  GDR 125
            GDR
Sbjct: 1017 GDR 1019



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 43/120 (35%), Positives = 45/120 (37%), Gaps = 33/120 (27%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           GA G  GP  A G                   PG  A R   P S   P PP PP    G
Sbjct: 816 GARGAQGPPGATG------------------FPG-AAGRVGPPGSNGNPGPPGPP----G 852

Query: 65  PASASGP-GAAGPASSPPPAG-PG-PGPALPAVRLSLVRLGEP--DSAGAGEPPATPAGL 119
           P+   GP GA G +  P  AG PG  GPA P         GEP  D     E P  P GL
Sbjct: 853 PSGKDGPKGARGDSGPPGRAGEPGLQGPAGPP-----GEKGEPGDDGPSGAEGPPGPQGL 907



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 38/113 (33%), Positives = 43/113 (38%), Gaps = 24/113 (21%)

Query: 464 GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG----GGKAGGPGVAAEPGTPFS 519
           G PG   PA      G PGP       S    LP P G    GGK G  GV  E G P  
Sbjct: 573 GPPGPAGPAGERGEQGAPGP-------SGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL 625

Query: 520 IGRFATLTLQERRDRGAEKEHKRYHSLG-NISRGGSGGSGSGGEK----PSGP 567
           +G         R +RG   E     + G    RG  G  G+ G K    P+GP
Sbjct: 626 VG--------PRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGP 670



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 39/130 (30%), Positives = 47/130 (36%), Gaps = 20/130 (15%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQTPVPPQPPQP-- 61
           GA G +GP    GD  E     +  EG     PG DG    +GP     P      +   
Sbjct: 687 GAAGIAGPKGDRGDVGE-----KGPEG----APGKDGGRGLTGPIGPPGPAGANGEKGEV 737

Query: 62  -PPGPASASG----PGAAGPASSPPP---AGPGPGPALPAVRLSLVRLGEPDSAGAGEPP 113
            PPGPA ++G    PG  G    P P   AGP      P  +      G+   AGA  P 
Sbjct: 738 GPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQ 797

Query: 114 ATPAGLGSGG 123
                 G  G
Sbjct: 798 GPSGAPGPQG 807



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 39/119 (32%), Positives = 45/119 (37%), Gaps = 20/119 (16%)

Query: 463 PGTPGTTPPAASSSRGGEPGP-GPL-PRSLSRSNSLPHPAGG----------GKAGGPGV 510
           PG PG    A    + GE GP GP   R    +  LP   G           G+AG PGV
Sbjct: 179 PGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGV 238

Query: 511 AAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNI-SRGGSGGSGSGGEKPSGPV 568
             E G+P   G    +       RG   E  R    G   +RG  G  G  G  P GPV
Sbjct: 239 KGESGSPGENGSPGPM-----GPRGLPGERGRTGPAGAAGARGNDGQPGPAG--PPGPV 290



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 29/104 (27%), Positives = 36/104 (34%), Gaps = 19/104 (18%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPGPASASGP----------GAAGPASSPPPAGPGPGP 89
           G    SG         P  P+  PG    +GP          G  GPA  P P GP  GP
Sbjct: 237 GVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP 296

Query: 90  ALPAVRLSLVRLGEPDSAG-------AGEP--PATPAGLGSGGD 124
             P    +    G   + G        GEP  P +P   G+ G+
Sbjct: 297 GFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGN 340



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 35/123 (28%), Positives = 38/123 (30%), Gaps = 13/123 (10%)

Query: 1   MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQ 60
           M   G  G  GP  A G            +GF       G    SGP   + P  P PP 
Sbjct: 134 MGPMGPRGPPGPAGAPGP-----------QGFQGNPGEPGEPGVSGPMGPRGP--PGPPG 180

Query: 61  PPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLG 120
            P     A  PG AG    P P G    P  P +       G P   GA      P   G
Sbjct: 181 KPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKG 240

Query: 121 SGG 123
             G
Sbjct: 241 ESG 243



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 39/128 (30%), Positives = 42/128 (32%), Gaps = 31/128 (24%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G+ G  GP    G+        R R G     P   A  R          PP P  P  G
Sbjct: 249 GSPGPMGPRGLPGE--------RGRTG-----PAGAAGARGNDGQPGPAGPPGPVGPAGG 295

Query: 65  PASASGPGA---AGPASSPPP---AGPGPGPALPAVRLSLVRLGEPDSAGAGEPPAT--- 115
           P     PGA   AGP  +  P    GP   P  P         G P  AGA   P T   
Sbjct: 296 PGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTP---------GSPGPAGASGNPGTDGI 346

Query: 116 PAGLGSGG 123
           P   GS G
Sbjct: 347 PGAKGSAG 354



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 42/127 (33%), Positives = 48/127 (37%), Gaps = 22/127 (17%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPP-----QPP 59
           G  G +GP  A GD          R G   L    G   R G A  Q  V P     +  
Sbjct: 465 GPSGLAGPKGANGDPG--------RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDG 516

Query: 60  QP-PPGPASASG-------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGE 111
           +P PPGP  A G       PG  G    P  AG    P  P +R    + GE  +AG   
Sbjct: 517 RPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP-P 575

Query: 112 PPATPAG 118
            PA PAG
Sbjct: 576 GPAGPAG 582



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 32/109 (29%), Positives = 39/109 (35%), Gaps = 4/109 (3%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PG T PA    R G PG    P     +         G  G PG    PG+P   G  
Sbjct: 954  GPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAG-- 1011

Query: 524  ATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSR 572
             T    +R + GA+         G  +RG  G  G  G+K     P  R
Sbjct: 1012 PTGKQGDRGEAGAQGPMGPSGPAG--ARGIQGPQGPRGDKGEAGEPGER 1058



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 56/200 (28%), Positives = 67/200 (33%), Gaps = 28/200 (14%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGG----APLSPLPKAGSITYRFGSAGQDTQFC 441
           AA  AG  G+R G+  E+ PE A  G  GG     P+ P   AG+     G  G+     
Sbjct: 688 AAGIAGPKGDR-GDVGEKGPEGA-PGKDGGRGLTGPIGPPGPAGAN----GEKGE----- 736

Query: 442 LWDLTEDVLYPHPP-LARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPA 500
                  V  P P   A  R  PG  G T P   +   G PG    P +           
Sbjct: 737 -------VGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQK- 788

Query: 501 GGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSG 560
             G AG PG     G P   G   T     +  RGA+         G   R G  GS   
Sbjct: 789 --GDAGAPGPQGPSGAPGPQG--PTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGN 844

Query: 561 GEKPSGPVPRSRLDPAKVLG 580
              P  P P  +  P    G
Sbjct: 845 PGPPGPPGPSGKDGPKGARG 864



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 21/55 (38%), Positives = 25/55 (45%), Gaps = 15/55 (27%)

Query: 463 PGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTP 517
           PGTPG+  PA +S   G PG   +            P   G AG PG+A  PG P
Sbjct: 326 PGTPGSPGPAGAS---GNPGTDGI------------PGAKGSAGAPGIAGAPGFP 365



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 26/82 (31%), Positives = 31/82 (37%), Gaps = 14/82 (17%)

Query: 43  RRSGPASAQTPVPPQPPQPPPGPASASGP----GAAGPASSPPPAGPGPGPALPAVRLSL 98
           ++  P   +  V P+ P  P GPA   GP    G  G   +P P G    P  P      
Sbjct: 36  QKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTP------ 89

Query: 99  VRLGEPDSAGAGEPPATPAGLG 120
              G P   G   PP  P GLG
Sbjct: 90  ---GNPGPPGPPGPPG-PPGLG 107



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 38/142 (26%), Positives = 42/142 (29%), Gaps = 36/142 (25%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPG 64
           G  G  GP    GD  E            K  PG    R   P +   P PP PP  PPG
Sbjct: 57  GPAGEQGPRGDRGDKGE------------KGAPGP-RGRDGEPGTPGNPGPPGPPG-PPG 102

Query: 65  PASASG----------------------PGAAGPASSPPPAGPGPGPALPAVRLSLVRLG 102
           P    G                       G  GP     P GP   P     + +    G
Sbjct: 103 PPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPG 162

Query: 103 EPDSAGAGEPPATPAGLGSGGD 124
           EP  +G   P   P   G  GD
Sbjct: 163 EPGVSGPMGPRGPPGPPGKPGD 184



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 23/112 (20%)

Query: 460 RTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFS 519
           R LPGTPGT  P  +S   G PG    P        +P     G+ G  G+A   G    
Sbjct: 650 RGLPGTPGTDGPKGASGPAGPPGAQGPP----GLQGMP-----GERGAAGIAGPKGDRGD 700

Query: 520 IGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEK----PSGP 567
           +G        E+   GA  +       G I  G  G +G+ GEK    P GP
Sbjct: 701 VG--------EKGPEGAPGKDGGRGLTGPI--GPPGPAGANGEKGEVGPPGP 742



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 49/161 (30%), Positives = 56/161 (34%), Gaps = 50/161 (31%)

Query: 3   AGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQTPVPPQPPQP 61
           A G +G  GP    G             GF    PG  GA   +GP  A+ P   Q P+ 
Sbjct: 274 ARGNDGQPGPAGPPGPVGPAGGP-----GF----PGAPGAKGEAGPTGARGPEGAQGPRG 324

Query: 62  PPG------PASASG-------PGAAGPASSPPPAG----------PGP----GPALPAV 94
            PG      PA ASG       PGA G A +P  AG          PGP    GP  P  
Sbjct: 325 EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKG 384

Query: 95  RLSLVRL----------GEPDSAGAGEPPATPAGLGSGGDR 125
           +     +          GEP  AG   P   P   G  G R
Sbjct: 385 QTGEPGIAGFKGEQGPKGEPGPAG---PQGAPGPAGEEGKR 422



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 58/193 (30%), Positives = 62/193 (32%), Gaps = 44/193 (22%)

Query: 386 AATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDL 445
           +A A GA GER    E   P  AG     GA   P  K        G AGQ         
Sbjct: 745 SAGARGAPGERG---ETGPPGPAGFAGPPGADGQPGAKGEQ-----GEAGQKG------- 789

Query: 446 TEDVLYPHPPLARTRTLP-GTPGTTPPAASSSRGGEPGPGPLPRSLSR-----SNSLPHP 499
             D   P P        P G  G T P  +    G PG    P +  R     SN  P P
Sbjct: 790 --DAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGP 847

Query: 500 AG----GGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSG 555
            G     GK G  G   + G P   GR     LQ       EK             G  G
Sbjct: 848 PGPPGPSGKDGPKGARGDSGPP---GRAGEPGLQGPAGPPGEK-------------GEPG 891

Query: 556 GSG-SGGEKPSGP 567
             G SG E P GP
Sbjct: 892 DDGPSGAEGPPGP 904



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 46/176 (26%), Positives = 60/176 (34%), Gaps = 16/176 (9%)

Query: 357  EGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGA 416
            EG   A G   +     V  D   T A  A  A G  G         +    G   A G 
Sbjct: 968  EGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQG- 1026

Query: 417  PLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSS 476
            P+ P   AG+   +     +  +    +  E  L  H      + LPG PG +    +S 
Sbjct: 1027 PMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASG 1086

Query: 477  RGGEPGP----GPL-PRSLSRSNSLPHPAGG----------GKAGGPGVAAEPGTP 517
              G  GP    GP+ P     +N +P P G           G AG PG    PG P
Sbjct: 1087 PAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPP 1142



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 29/77 (37%), Positives = 34/77 (44%), Gaps = 15/77 (19%)

Query: 460 RTLPGTPGTTPPA-ASSSRG--GEPGPGPLPRSLSRSNSLPHPAGGGKAG--------GP 508
           R LPG  G T PA A+ +RG  G+PGP   P  +  +     P   G  G        GP
Sbjct: 257 RGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGP 316

Query: 509 ----GVAAEPGTPFSIG 521
               G   EPGTP S G
Sbjct: 317 EGAQGPRGEPGTPGSPG 333



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 21/68 (30%), Positives = 25/68 (36%)

Query: 464  GTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRF 523
            G PG   P+      G PGP   P    RS         G  G PG    PG    +  F
Sbjct: 1095 GPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAF 1154

Query: 524  ATLTLQER 531
            A L  +E+
Sbjct: 1155 AGLGPREK 1162



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 39/134 (29%), Positives = 43/134 (32%), Gaps = 15/134 (11%)

Query: 383 AEEAATAAGADGERSGEEEEEEPEAAGT-GSAGGAPLSPLPKAGSITYRFGSAGQDTQFC 441
           A  A   AG  G R  E  +      GT GS G A  S  P    I    GSAG      
Sbjct: 301 APGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPG--- 357

Query: 442 LWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAG 501
                   +   P     R  PG  G T P     + GEPG   +            P  
Sbjct: 358 --------IAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPG---IAGFKGEQGPKGEPGP 406

Query: 502 GGKAGGPGVAAEPG 515
            G  G PG A E G
Sbjct: 407 AGPQGAPGPAGEEG 420



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 5/67 (7%)

Query: 453 HPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGG----GKAGGP 508
           +P L   +   G PG    + S    G PGP   PR L        PAG     G  G P
Sbjct: 223 YPGLDGAKGEAGAPGVKGESGSPGENGSPGPMG-PRGLPGERGRTGPAGAAGARGNDGQP 281

Query: 509 GVAAEPG 515
           G A  PG
Sbjct: 282 GPAGPPG 288



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 37/138 (26%), Positives = 45/138 (32%), Gaps = 23/138 (16%)

Query: 5   GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGD----GAARRSGPASAQ-------TP 53
           G  G  GP  A G+  +   +        + LPG     GAA   GPA           P
Sbjct: 531 GVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAP 590

Query: 54  VP------PQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSA 107
            P      P PP PP         G  G A +P   GP      P  R      G P + 
Sbjct: 591 GPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGER------GSPGAQ 644

Query: 108 GAGEPPATPAGLGSGGDR 125
           G   P   P   G+ G +
Sbjct: 645 GLQGPRGLPGTPGTDGPK 662



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 25/74 (33%), Positives = 28/74 (37%), Gaps = 6/74 (8%)

Query: 454 PPLARTRTLPGTPGTTPPAASSSRGGEPG----PGPLPRSLSRSNS--LPHPAGGGKAGG 507
           P L   R L G PG   P       G PG    PGP     +R     +  P   G  G 
Sbjct: 485 PGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGE 544

Query: 508 PGVAAEPGTPFSIG 521
           PG A E G P + G
Sbjct: 545 PGKAGEKGLPGAPG 558



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/97 (30%), Positives = 32/97 (32%), Gaps = 13/97 (13%)

Query: 40  GAARRSGPASAQTPVPPQPPQPPPG----PASASGPGAAGPASSPPPA---GPGPGPALP 92
           G     GP  A  P  P   Q PPG    P      G AGP          GP   P   
Sbjct: 654 GTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKD 713

Query: 93  AVRLSLVRLGEPDSAGA-GE-----PPATPAGLGSGG 123
             R     +G P  AGA GE     PP      G+ G
Sbjct: 714 GGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARG 750



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 26/82 (31%), Positives = 30/82 (36%), Gaps = 24/82 (29%)

Query: 464 GTPGTTPPAASSSRGGEPG----------PGP-----------LPRSLSRSN--SLPHPA 500
           G PG   PA      GEPG          PGP           LP          LP P+
Sbjct: 873 GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 932

Query: 501 GG-GKAGGPGVAAEPGTPFSIG 521
           G  GK G PG + + G P  +G
Sbjct: 933 GEPGKQGAPGASGDRGPPGPVG 954



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 38/139 (27%), Positives = 48/139 (34%), Gaps = 14/139 (10%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSP----LPKAGSITYRFGSAGQDTQFCLWDLT 446
           G  G +    E      AG   A G P  P    LP A  +T R G AG   +       
Sbjct: 453 GLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAP 512

Query: 447 EDVLYPHPPLAR-TRTLPGTPGTTPPAASSSRGGEPG----PGP-----LPRSLSRSNSL 496
            +   P PP  +  R  PG  G   P  ++   G+ G    PG      LP     + + 
Sbjct: 513 GEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAA 572

Query: 497 PHPAGGGKAGGPGVAAEPG 515
             P   G AG  G    PG
Sbjct: 573 GPPGPAGPAGERGEQGAPG 591



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 22/68 (32%), Positives = 27/68 (39%), Gaps = 10/68 (14%)

Query: 57  QPPQPPPGPASASGP-GAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPAT 115
           Q P+  PG     GP GA+GPA  P   GP     +P         GE  +AG   P   
Sbjct: 647 QGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMP---------GERGAAGIAGPKGD 697

Query: 116 PAGLGSGG 123
              +G  G
Sbjct: 698 RGDVGEKG 705



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 54/216 (25%), Positives = 64/216 (29%), Gaps = 43/216 (19%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVL 450
           GA G R  + E   P   G     G P  P           G   +        + +  +
Sbjct: 75  GAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPM 134

Query: 451 YPHPPLARTRTLPGTPGTTPPAASSSRGGEPG-------------PGPLPRSLSRSNSLP 497
            P  P    R  PG  G   P       GEPG             PGP P          
Sbjct: 135 GPMGP----RGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGP-PGKPGDDGEAG 189

Query: 498 HPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNI-----SRG 552
            P   G+ G PG     G P + G                K H+ Y  L        + G
Sbjct: 190 KPGKAGERGPPGPQGARGFPGTPG------------LPGVKGHRGYPGLDGAKGEAGAPG 237

Query: 553 GSGGSGSGGEK----PSGP--VP--RSRLDPAKVLG 580
             G SGS GE     P GP  +P  R R  PA   G
Sbjct: 238 VKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAG 273



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 25/90 (27%), Positives = 31/90 (34%), Gaps = 10/90 (11%)

Query: 46  GPASAQTPVPPQPPQPP---------PGPASASG-PGAAGPASSPPPAGPGPGPALPAVR 95
           GP   Q P   Q P+           PGP    G PG  G    P P GP   P L    
Sbjct: 51  GPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNF 110

Query: 96  LSLVRLGEPDSAGAGEPPATPAGLGSGGDR 125
            + +  G  + AG  +       +G  G R
Sbjct: 111 AAQMAGGFDEKAGGAQLGVMQGPMGPMGPR 140



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 2/50 (4%)

Query: 40   GAARRSGPASAQTPVPPQPPQPPPGPASASGP-GAAGPASSPPPAGP-GP 87
            GA    GP  +  P  P   Q   G A A GP G +GPA +    GP GP
Sbjct: 996  GAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGP 1045



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 41/136 (30%), Positives = 51/136 (37%), Gaps = 14/136 (10%)

Query: 391 GADGERSGEEEEEEPEAAGTGSAGGAPLSP--LPKAGSITYRFGSAGQDTQFCLWDLTED 448
           GA GE      + E  + G   + G P+ P  LP     T   G+AG        D    
Sbjct: 228 GAKGEAGAPGVKGESGSPGENGSPG-PMGPRGLPGERGRTGPAGAAGARGN----DGQPG 282

Query: 449 VLYPHPPL--ARTRTLPGTPGTTPPAA-SSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKA 505
              P  P+  A     PG PG    A  + +RG E   GP  R    +   P PAG   +
Sbjct: 283 PAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGP--RGEPGTPGSPGPAGA--S 338

Query: 506 GGPGVAAEPGTPFSIG 521
           G PG    PG   S G
Sbjct: 339 GNPGTDGIPGAKGSAG 354



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 41/149 (27%), Positives = 49/149 (32%), Gaps = 31/149 (20%)

Query: 5   GAEGGSGPGAAMGDCAEIK-SQFRTREGFYKLLPGD-------GAARRSGPASAQTPVPP 56
           G +G +GP    G   E   + F+  +G  K  PG        G A   G   A+     
Sbjct: 372 GPQGATGPLGPKGQTGEPGIAGFKGEQG-PKGEPGPAGPQGAPGPAGEEGKRGARGEPGG 430

Query: 57  QPPQPPPGPASASG-------PGAAGPASSPPPAGPG-----------PG----PALPAV 94
             P  PPG   A G        G AGP  +P   GP            PG    P LP  
Sbjct: 431 VGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGA 490

Query: 95  RLSLVRLGEPDSAGAGEPPATPAGLGSGG 123
           R    R G+    G   P   P   G  G
Sbjct: 491 RGLTGRPGDAGPQGKVGPSGAPGEDGRPG 519



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 34/98 (34%), Positives = 37/98 (37%), Gaps = 23/98 (23%)

Query: 5    GAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPG-DGAARRSGPASAQ----------TP 53
            G  G  GP    G   E       REG     PG DG   R G A  +           P
Sbjct: 948  GPPGPVGPPGLTGPAGE-----PGREGS----PGADGPPGRDGAAGVKGDRGETGAVGAP 998

Query: 54   VPPQPPQPPPGPASASG-PGAAGPASSPPPAGPGPGPA 90
              P PP   PGPA  +G  G  G A +  P GP  GPA
Sbjct: 999  GAPGPP-GSPGPAGPTGKQGDRGEAGAQGPMGPS-GPA 1034


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 25/63 (39%), Positives = 29/63 (46%), Gaps = 5/63 (7%)

Query: 46  GPASAQTPVPPQPPQPPPGPASASGPGAAGPA-----SSPPPAGPGPGPALPAVRLSLVR 100
           GPA A   +PP P  PPP P  ++GP    P        PPP  P P P LPA    L  
Sbjct: 322 GPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLAS 381

Query: 101 LGE 103
           + E
Sbjct: 382 MSE 384



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 26/70 (37%), Positives = 30/70 (42%), Gaps = 21/70 (30%)

Query: 38  GDGAARRSGPASAQTPV--------------PPQPPQPPPGPASASGPGAAGPASSPPPA 83
           GD +A   G  +A  P               PP PP  PPGPA AS        + PPP 
Sbjct: 282 GDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS-------VALPPPP 334

Query: 84  GPGPGPALPA 93
           GP P P LP+
Sbjct: 335 GPPPPPPLPS 344



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 27/84 (32%), Positives = 33/84 (39%), Gaps = 18/84 (21%)

Query: 45  SGPASAQTP---VPPQPPQPPPGPASASGPGAA--------GPASSPPPAGPGPGPALPA 93
           + PAS +TP   V        PG  +AS P           GP + PPP    PGPA  +
Sbjct: 268 AAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS 327

Query: 94  VRLSLVRLGEPDSAGAGEPPATPA 117
           V L       P   G   PP  P+
Sbjct: 328 VAL-------PPPPGPPPPPPLPS 344



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 24/75 (32%), Positives = 28/75 (37%), Gaps = 1/75 (1%)

Query: 36  LPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVR 95
           LP  G      P      VPP PP PP  P  ASG   A  +    P   G   A+   +
Sbjct: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPL-TGLAAAIAGAK 400

Query: 96  LSLVRLGEPDSAGAG 110
           L  V   E  S  +G
Sbjct: 401 LRKVSRMEDTSFPSG 415


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.135    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,002,893
Number of Sequences: 37866
Number of extensions: 2542840
Number of successful extensions: 55236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1052
Number of HSP's successfully gapped in prelim test: 1611
Number of HSP's that attempted gapping in prelim test: 20406
Number of HSP's gapped (non-prelim): 22035
length of query: 674
length of database: 18,247,518
effective HSP length: 109
effective length of query: 565
effective length of database: 14,120,124
effective search space: 7977870060
effective search space used: 7977870060
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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