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Search of human proteins with 57529737
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
(1066 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 2156 0.0
gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens] 927 0.0
gi|46559761 PDZ domain containing 4 [Homo sapiens] 722 0.0
gi|87241872 ring finger protein 151 [Homo sapiens] 103 7e-22
gi|112382257 InaD-like [Homo sapiens] 99 2e-20
gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens] 98 4e-20
gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens] 98 4e-20
gi|45827729 scribble isoform b [Homo sapiens] 92 3e-18
gi|45827731 scribble isoform a [Homo sapiens] 92 3e-18
gi|148746189 multiple PDZ domain protein [Homo sapiens] 90 1e-17
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 87 1e-16
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 87 1e-16
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 82 2e-15
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 82 2e-15
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 82 4e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 81 5e-15
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 81 5e-15
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 77 7e-14
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens] 76 2e-13
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens] 76 2e-13
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens] 76 2e-13
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 74 6e-13
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 74 7e-13
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 74 7e-13
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 73 1e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 72 3e-12
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap... 72 3e-12
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap... 72 3e-12
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap... 72 3e-12
gi|87196343 PDZ domain containing 2 [Homo sapiens] 68 5e-11
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 2156 bits (5586), Expect = 0.0
Identities = 1066/1066 (100%), Positives = 1066/1066 (100%)
Query: 1 MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRL 60
MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRL
Sbjct: 1 MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRL 60
Query: 61 SAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQV 120
SAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQV
Sbjct: 61 SAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQV 120
Query: 121 LLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGAL 180
LLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGAL
Sbjct: 121 LLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGAL 180
Query: 181 HKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGG 240
HKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGG
Sbjct: 181 HKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGG 240
Query: 241 KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI
Sbjct: 241 KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
Query: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQT 360
HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQT
Sbjct: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQT 360
Query: 361 DITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEV 420
DITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEV
Sbjct: 361 DITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEV 420
Query: 421 DLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN 480
DLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN
Sbjct: 421 DLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN 480
Query: 481 REEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTA 540
REEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTA
Sbjct: 481 REEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTA 540
Query: 541 SVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPL 600
SVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPL
Sbjct: 541 SVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPL 600
Query: 601 AGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSAT 660
AGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSAT
Sbjct: 601 AGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSAT 660
Query: 661 PYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWM 720
PYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWM
Sbjct: 661 PYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWM 720
Query: 721 LHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLR 780
LHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLR
Sbjct: 721 LHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLR 780
Query: 781 RAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKER 840
RAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKER
Sbjct: 781 RAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKER 840
Query: 841 RASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQM 900
RASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQM
Sbjct: 841 RASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQM 900
Query: 901 SLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTD 960
SLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTD
Sbjct: 901 SLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTD 960
Query: 961 DDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILEL 1020
DDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILEL
Sbjct: 961 DDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILEL 1020
Query: 1021 SHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066
SHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV
Sbjct: 1021 SHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066
>gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]
Length = 778
Score = 927 bits (2396), Expect = 0.0
Identities = 481/777 (61%), Positives = 609/777 (78%), Gaps = 33/777 (4%)
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTK-MFTPPSESQLVDTGTQTDI 362
+ +VNG+DLS+ATH++AVEAF+ AKEPIVVQVLRRTP ++ + SE QL++ TQTDI
Sbjct: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDI 80
Query: 363 TFEHIMALTKMSSPSPPVLD--PYLLPEE----HPSAHEYYDPNDYIGDIHQEMDR-EEL 415
TFEHIMAL K+ P+PPV D P+LL + HP HE+Y+ N+YI + + DR E+
Sbjct: 81 TFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDF 140
Query: 416 ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
E EEV+L R++SQ+KLGLTVCYRTDDE+D GIY+SE+DPNSIAAKDGRIREGDRI+QING
Sbjct: 141 EYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
Query: 476 IEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQA 535
+VQNREEAVALL+++E K LL+ARPE+QLDEGW++D+RN+FL++L+++MLEE+H++A
Sbjct: 201 EDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELNLEMLEEEHNEA 260
Query: 536 MQFTASVLQQ-KKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAT 594
MQ TA+ ++Q KK +E+ GTTDTAT SN HEKDSGVGRTDES RNDESSEQEN +D
Sbjct: 261 MQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQENAAEDPN 320
Query: 595 ASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKC 654
++S L +R L SQDTLGS +L + NES +S + D+D +G P ++CERFR+LLELKC
Sbjct: 321 STS--LKSKRDLGQSQDTLGSVELQY-NESLVSGEYIDSDCIGNPDEDCERFRQLLELKC 377
Query: 655 QVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQ 714
++++ Y LYY S ++ + + E V+ EL+LLNEELR+IELEC +I++AH++Q++ +Q
Sbjct: 378 KIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNIMQAHRLQKVTDQ 437
Query: 715 YRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEIS 774
Y + W LH+ GFRNYNTSID++R +L DI E PEKSDKDSSSAYNT ESCRSTPLT++ S
Sbjct: 438 YGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYNTAESCRSTPLTVDRS 497
Query: 775 PDNSLRRAAEGISCPSSEGAVGTTE-AYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQ 833
PD+SL R + + + T+ + G +SK + S K +
Sbjct: 498 PDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKE-------------STSTKAKTTEQGC 544
Query: 834 PLESKERRASDGSRSPTPSQKLGS--AYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKS 891
ESKE + +GS+ P + + YL YH S Y++A+IPAHA+HYQSYMQLIQQKS
Sbjct: 545 SAESKE-KVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQQKS 603
Query: 892 AVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIR 951
AVEYAQSQ+SLVSMCK+ S SEP+MEWKVKIRSDGTRYITKRPVRDR+L+ERALKI+
Sbjct: 604 AVEYAQSQLSLVSMCKE--SQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKIK 661
Query: 952 EERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKE--QQAA 1009
EERSGMTTDDD +SEMKMGRYWSKEERKQHLV+AKEQRRRREFMM+SRL+CLKE Q +
Sbjct: 662 EERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSGS 721
Query: 1010 DDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066
+ +KE+NI+ELSHKKMMKKRNKKI DNWMTIQEL+THG KSPDGTRV+N+FLSVTTV
Sbjct: 722 EGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV 778
Score = 35.8 bits (81), Expect = 0.22
Identities = 15/39 (38%), Positives = 26/39 (66%)
Query: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDL 312
D GI+VS++ + AAK+G ++ DRI+++NG D+
Sbjct: 165 DDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV 203
>gi|46559761 PDZ domain containing 4 [Homo sapiens]
Length = 769
Score = 722 bits (1863), Expect = 0.0
Identities = 396/779 (50%), Positives = 521/779 (66%), Gaps = 43/779 (5%)
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDIT 363
+++VNG++LS+ + +Q ++A +++KEP+V+QVLRR+PR + + + QLVD+GTQTDIT
Sbjct: 18 MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
Query: 364 FEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDR-EELELEEVDL 422
FEHIMAL K+ P+PP++ + E P +HEYYDP +++ QE DR +ELE EEV+L
Sbjct: 78 FEHIMALGKLRPPTPPMV----ILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVEL 133
Query: 423 YRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNRE 482
Y+ + +DKLGL VCYRTDDE+D+GIY+ E++PNSIAAKDGRIREGDRIIQING++VQNRE
Sbjct: 134 YKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNRE 193
Query: 483 EAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASV 542
EAVA+L+ EEN N SLL+ARPE QL + W D DR+DFLDD + E +A + +
Sbjct: 194 EAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSE--NEGELRARKLKSPP 251
Query: 543 LQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAG 602
QQ ++E+ G D LSN E DSGVGRTDESTRN+ESSE + GD+ +S+N
Sbjct: 252 AQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGS 311
Query: 603 QRKLTCSQDTLGSGDLPFSNESFIS--ADCTDADYLGIPVDECERFRELLELKCQVKSAT 660
RK D L S D FS +S ++ A D G+ +E ER+RELLE+KC +++
Sbjct: 312 LRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYRELLEIKCHLENGN 371
Query: 661 PYGLYYP-----SGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQY 715
GL +P + LD ++ ES+ E+ +L EELR +E +C +I+RA KMQQL+E+
Sbjct: 372 QLGLLFPRASGGNSALDVNRN--ESLGHEMAMLEEELRHLEFKCRNILRAQKMQQLRERC 429
Query: 716 RESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISP 775
++W+L + S + ++HELSDI+ELPEKSDKDS+SAYNTGESCRSTPL +E P
Sbjct: 430 MKAWLLEEESLYDLAAS-EPKKHELSDISELPEKSDKDSTSAYNTGESCRSTPLLVEPLP 488
Query: 776 DNSLRRAAEGISC-----PSSEGAVGTTEAYGPASK-NLLSITEDPEVGTPTYSPSLKEL 829
++ LRRA G S P A A P S S++ DPE G ++
Sbjct: 489 ESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQHA------ 542
Query: 830 DPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQ 889
+ER G R+P L S + +H +HY S +QL
Sbjct: 543 --------EER----GRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPT 590
Query: 890 KSAVEYAQSQMSLVSMCK--DLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERA 947
+ E +SL + +++ PRMEWKVK+RSDGTRY+ KRPVRDRLL+ RA
Sbjct: 591 RGLEELGHGPLSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARA 650
Query: 948 LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQ 1007
LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHL++A+EQR+RREFMMQSRL+CL+EQQ
Sbjct: 651 LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQ 710
Query: 1008 AADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066
D + E+NI+ LSH+K MKKRNKKI DNW+TIQE+L HG +S DG RVYN LSVTTV
Sbjct: 711 NGDSKPELNIIALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV 769
Score = 38.1 bits (87), Expect = 0.045
Identities = 71/337 (21%), Positives = 127/337 (37%), Gaps = 27/337 (8%)
Query: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
D GI+V ++ + AAK+G ++ DRII++NG D+ ++AV A + +E +
Sbjct: 151 DDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAV-AILSQEENTNI 207
Query: 334 QVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDP-----YLLPE 388
+L P +++ +S D D E+ L SPP P P+
Sbjct: 208 SLLVARPESQLAKRWKDSDRDD--FLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPD 265
Query: 389 EHPSAHEYYDPNDYIGDIHQEMDREELELEEV-------DLYRMNSQDKLGLTVCYRTDD 441
P + + +G + EE ++ S K GL
Sbjct: 266 AGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGL-------Q 318
Query: 442 EDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIA 501
D + +S+ A+ + GD + + E + E + + EN N L +
Sbjct: 319 GDALQSRDFHFSMDSLLAEGAGLGGGD-VPGLTDEEYERYRELLEIKCHLENGN-QLGLL 376
Query: 502 RPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATIL 561
P +D +RN+ L M MLEE+ ++L+ +K + A +L
Sbjct: 377 FPRASGGNSALDVNRNESLGH-EMAMLEEELRHLEFKCRNILRAQKMQQLRERCMKAWLL 435
Query: 562 SNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSN 598
+ D + +D S E + D+T++ N
Sbjct: 436 EEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYN 472
>gi|87241872 ring finger protein 151 [Homo sapiens]
Length = 245
Score = 103 bits (258), Expect = 7e-22
Identities = 56/169 (33%), Positives = 83/169 (49%), Gaps = 6/169 (3%)
Query: 2 GFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLS 61
G++L+ F D + C++CH VL+ P PC H+FC C+L W+ ++ +CP CR +
Sbjct: 4 GYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQKTCPC-CRKEVK 62
Query: 62 AKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVL 121
K++ H+ L++ I +L++KC A GC L H + C F C + GC +
Sbjct: 63 RKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQV 122
Query: 122 LRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHN 170
R + H R C RC GCG L E+ H C R L HN
Sbjct: 123 PRGTLAEH-RQHCQQGSQQRCPLGCGATLDPAER--ARHNCYREL--HN 166
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 99.0 bits (245), Expect = 2e-20
Identities = 79/273 (28%), Positives = 135/273 (49%), Gaps = 29/273 (10%)
Query: 240 GKGEETKS--------LTLVLHRDSGSLGFNIIGGRPSVDN-HDGSSSEGIFVSKIVDSG 290
G+GEET + + + + SLG +I+GG+ + +G +GIF+ ++++
Sbjct: 1052 GEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDS 1111
Query: 291 PAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIV--VQVLRRTPRTKMFTPP 348
PA K L+ D+I+EV+G DL A+H +AVEA K A P+V VQ L TPR
Sbjct: 1112 PAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHN 1171
Query: 349 SESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQ 408
+++ TG Q T E K +PP P LP + + + D N+
Sbjct: 1172 KANKI--TGNQNQDTQE---KKEKRQGTAPP---PMKLPPPYKALTDDSDENEEEDAFTD 1223
Query: 409 EMDREEL-----ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGR 463
+ R+ EL ++L + ++ LGL++ D + I++ I+P AA DGR
Sbjct: 1224 QKIRQRYADLPGELHIIELEK--DKNGLGLSLA-GNKDRSRMSIFVVGINPEGPAAADGR 1280
Query: 464 IREGDRIIQING--IEVQNREEAVALLTSEENK 494
+R GD +++IN + ++ + A A++ + +K
Sbjct: 1281 MRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
Score = 58.9 bits (141), Expect = 2e-08
Identities = 58/230 (25%), Positives = 95/230 (41%), Gaps = 54/230 (23%)
Query: 259 LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHD 318
LG +I+G R + G+F+S IV G A +G L D+I+ VNG D+ A+ +
Sbjct: 1544 LGLSIVGKR---------NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQE 1594
Query: 319 QAVEAFKTAKEPIVVQV--LRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSP 376
K A+ + +++ LR T T SQ G+Q
Sbjct: 1595 TVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQ----GSQ----------------- 1633
Query: 377 SPPVLDPYLLPEEHPSAHEYYDP----------NDYIGDIHQEMDREELELEEVDLYRMN 426
H S H + P + D Q+ ++E V++ R
Sbjct: 1634 ----------QSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINREL 1683
Query: 427 SQDKLGLTVC-YRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
S D LG+++ R DI ++I+ I + +AA+ +++ GDRI+ ING
Sbjct: 1684 S-DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSING 1732
Score = 58.2 bits (139), Expect = 4e-08
Identities = 54/231 (23%), Positives = 89/231 (38%), Gaps = 57/231 (24%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L D LGF I+GG+ S G+ V IV G A ++G LQ D I+++ G +
Sbjct: 251 LINDGSGLGFGIVGGKTS----------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALT 371
+ T +Q + + + + V R TPP+ + L +AL
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP-------------VALP 347
Query: 372 KMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKL 431
++S P D E V+L R + Q L
Sbjct: 348 TVASKGP------------------------------GSDSSLFETYNVELVRKDGQ-SL 376
Query: 432 GLTV---CYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ 479
G+ + + + GIY+ I P S A +G I+ D+I+ ++G+ +Q
Sbjct: 377 GIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
Score = 58.2 bits (139), Expect = 4e-08
Identities = 68/288 (23%), Positives = 117/288 (40%), Gaps = 44/288 (15%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L +D LG ++ G + S IFV I GPAA +G ++I D ++E+N +
Sbjct: 1242 LEKDKNGLGLSLAGNKDR-------SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMF--TP-----PSESQLVDTGTQTDITF 364
L +H A KTA + + +R TP S S + D I+
Sbjct: 1295 LYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISS 1354
Query: 365 EH-----------------IMALTKMSSPSPPVLDPYLLPE--EHPSAHEYYDPNDYIG- 404
E +A+++M P + E P++ + D+ G
Sbjct: 1355 EEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGY 1414
Query: 405 ---DIHQEMDREELEL---EEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIA 458
+D + +E+ + + LGL++ D + I I E+ A
Sbjct: 1415 GGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN-AIVIHEVYEEGAA 1473
Query: 459 AKDGRIREGDRIIQINGIEVQN--REEAVALLTSEENKNFSLLIARPE 504
A+DGR+ GD+I+++NG++++N EEA+ L K L++ R E
Sbjct: 1474 ARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK-VRLVVYRDE 1520
Score = 55.5 bits (132), Expect = 3e-07
Identities = 77/308 (25%), Positives = 135/308 (43%), Gaps = 54/308 (17%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
ET ++ LV +D SLG I+G + +H G +S GI+V I+ A G +Q++D+
Sbjct: 362 ETYNVELV-RKDGQSLGIRIVGYVGT--SHTGEAS-GIYVKSIIPGSAAYHNGHIQVNDK 417
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRR--TPRTKMFTPPSE----------- 350
I+ V+G ++ + VE + A + + + ++RR + T PPS+
Sbjct: 418 IVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPP 477
Query: 351 ----SQLVDTGTQTD------------ITFEHIMALTKMSS-PSPPVLDPYLLPEEHPSA 393
+ V+T T D + ++I AL K+ P P E S
Sbjct: 478 ALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP-------ENELKSR 530
Query: 394 HEYYDPNDY---IGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYIS 450
E DY + + ++ ++ EL++ +LG+ V D D YIS
Sbjct: 531 WENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEV-----DSFDGHHYIS 584
Query: 451 EIDPNSIAAKDGRIREGDRIIQINGIEV--QNREEAVALLTSEENKNFSLLIARPELQLD 508
I G ++ D ++++NG+++ ++R EAV+ L E F+L+ R L D
Sbjct: 585 SIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFL-KEVPPPFTLVCCR-RLFDD 642
Query: 509 EGWMDDDR 516
E +D+ R
Sbjct: 643 EASVDEPR 650
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/118 (28%), Positives = 60/118 (50%), Gaps = 10/118 (8%)
Query: 220 FTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSE 279
FT Y LS A P G+E + + + + LG +I+GG+ + N
Sbjct: 1411 FTGYGGFQAPLSVDPATCPIVPGQE---MIIEISKGRSGLGLSIVGGKDTPLN------- 1460
Query: 280 GIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLR 337
I + ++ + G AA++G L D+I+EVNG DL ++H++A+ A + + + + V R
Sbjct: 1461 AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 242 GEETKSLTLVLHRD-SGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
G + + T+ ++R+ S +LG +I GGR S +F++ I SG AA+ L++
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGGRGSP-----LGDIPVFIAMIQASGVAARTQKLKV 1723
Query: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRT 339
DRI+ +NG+ L +H V K A I++QV+ T
Sbjct: 1724 GDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADT 1762
Score = 43.9 bits (102), Expect = 8e-04
Identities = 27/79 (34%), Positives = 47/79 (59%), Gaps = 5/79 (6%)
Query: 411 DREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRI 470
D E LE+ VDL + + LGL++ + + G++IS+I A DGR+ +GD+I
Sbjct: 1525 DEENLEIFPVDLQKKAGRG-LGLSIVGKRNGS---GVFISDIVKGGAADLDGRLIQGDQI 1580
Query: 471 IQINGIEVQN-REEAVALL 488
+ +NG +++N +E VA +
Sbjct: 1581 LSVNGEDMRNASQETVATI 1599
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/106 (24%), Positives = 58/106 (54%), Gaps = 5/106 (4%)
Query: 400 NDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAA 459
N+ + Q+M + ++E +D+ R ++ V R+ + + I++ ++ P S+A
Sbjct: 116 NEDFNSVIQQMAQGR-QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVAD 174
Query: 460 KDGRIREGDRIIQINGIEVQ---NREEAVALLTSEENKNFSLLIAR 502
+D R++E D+I+ IN + + ++A+ALL + + L++AR
Sbjct: 175 RDQRLKENDQILAINHTPLDQNISHQQAIALL-QQTTGSLRLIVAR 219
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/249 (21%), Positives = 90/249 (36%), Gaps = 66/249 (26%)
Query: 256 SGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSR- 314
+G LGF+++ R IFV + A ++ L+ +D+I+ +N L +
Sbjct: 142 TGGLGFSVVALRSQ-----NLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQN 196
Query: 315 ATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMS 374
+H QA+ + + + V R TK T S L DT + + H+
Sbjct: 197 ISHQQAIALLQQTTGSLRLIVAREPVHTKSST---SSSLNDTTLPETVCWGHV------- 246
Query: 375 SPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLT 434
EEV+L +N LG
Sbjct: 247 -------------------------------------------EEVEL--INDGSGLGFG 261
Query: 435 VCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN-REEAVALLTSEEN 493
+ G+ + I P +A +DGR++ GD I++I G VQ E VA +
Sbjct: 262 IVGGKTS----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG 317
Query: 494 KNFSLLIAR 502
+ +L+AR
Sbjct: 318 NSVRMLVAR 326
Score = 39.7 bits (91), Expect = 0.015
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 29/204 (14%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
E K + LV +D LGF+I+ + +D + I + +V G A + GGL DR
Sbjct: 683 EVKIVELV--KDCKGLGFSILDYQDPLD----PTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIV--------VQVLRRTPRTKMFTPPSESQLVD 355
++ VN L + +AVE K +V V+ + + +E +
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEF 796
Query: 356 TGTQTDITFEHIMALTKMSSPSP---------PVLDP----YLLPEEHPSAHEYYDPNDY 402
+GT DI I+ K P P LD + +E + E ++ +++
Sbjct: 797 SGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEF 856
Query: 403 IGDIHQEMD--REELELEEVDLYR 424
+ QEMD RE L EE +LY+
Sbjct: 857 LTPRLQEMDEEREMLVDEEYELYQ 880
>gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens]
Length = 317
Score = 98.2 bits (243), Expect = 4e-20
Identities = 68/206 (33%), Positives = 92/206 (44%), Gaps = 40/206 (19%)
Query: 1 MGFELDRFDGDVDPDLKCALCHKVLEDPLTTP-CGHVFCAGCVLPWVVQEGSCPARCRGR 59
MG+++ RF GDVD DL C +C VLE+P+ P C H FC C+ W Q+ +CP
Sbjct: 1 MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPV----D 56
Query: 60 LSAKELNHVLPLKR----LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHA 115
S + H+ P+ R ++ KL I C A GC VV+L L HL C+ P
Sbjct: 57 RSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNP------ 110
Query: 116 GCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQA 175
RPV C++GCGL + E H C + LR+ Q
Sbjct: 111 --------------------KRPV-TCEQGCGLEMPKDE--LPNHNCIKHLRSVVQQQQT 147
Query: 176 RLGALHK--ALKKEALRAGKREKSLV 199
R+ L K A K L KR+ L+
Sbjct: 148 RIAELEKTSAEHKHQLAEQKRDIQLL 173
>gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens]
Length = 317
Score = 98.2 bits (243), Expect = 4e-20
Identities = 68/206 (33%), Positives = 92/206 (44%), Gaps = 40/206 (19%)
Query: 1 MGFELDRFDGDVDPDLKCALCHKVLEDPLTTP-CGHVFCAGCVLPWVVQEGSCPARCRGR 59
MG+++ RF GDVD DL C +C VLE+P+ P C H FC C+ W Q+ +CP
Sbjct: 1 MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPV----D 56
Query: 60 LSAKELNHVLPLKR----LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHA 115
S + H+ P+ R ++ KL I C A GC VV+L L HL C+ P
Sbjct: 57 RSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNP------ 110
Query: 116 GCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQA 175
RPV C++GCGL + E H C + LR+ Q
Sbjct: 111 --------------------KRPV-TCEQGCGLEMPKDE--LPNHNCIKHLRSVVQQQQT 147
Query: 176 RLGALHK--ALKKEALRAGKREKSLV 199
R+ L K A K L KR+ L+
Sbjct: 148 RIAELEKTSAEHKHQLAEQKRDIQLL 173
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 91.7 bits (226), Expect = 3e-18
Identities = 99/344 (28%), Positives = 154/344 (44%), Gaps = 47/344 (13%)
Query: 156 RAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLV--AQLAAAQLELQMTA 213
RAG + L + ALQ GA H + AG + V ++ + + +T
Sbjct: 771 RAGVRVGDKLLEVNGVALQ---GAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP 827
Query: 214 LRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNH 273
LR + ++ R L R PP G + L R LGF+I GG+ S
Sbjct: 828 LRPEDDYSPRERRGGGL-RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYR 886
Query: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
G + GIFVS+I + G A + G LQ+ DR++ +NG D++ A HD AV + TA P +
Sbjct: 887 AGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAV-SLLTAASPTIA 943
Query: 334 QVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLD-PYLLPEEHPS 392
+L R + PPS T +A T +++ +P V P L P +
Sbjct: 944 LLLEREAGGPL--PPSPLPHSSPPTAA-------VATTSITTATPGVPGLPSLAPSLLAA 994
Query: 393 AHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDE------DDIG 446
A E P +EE+ L R LGL++ +D + G
Sbjct: 995 ALEGPYP-----------------VEEIRLPRAGG--PLGLSIVGGSDHSSHPFGVQEPG 1035
Query: 447 IYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN--REEAVALL 488
++IS++ P +AA+ G +R GDRI+ +NG +V++ +EAV+ L
Sbjct: 1036 VFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 81.3 bits (199), Expect = 5e-15
Identities = 75/268 (27%), Positives = 119/268 (44%), Gaps = 51/268 (19%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
E + LTL + R +G LG +I GG+ S EGIF+S++ + GPAA+ G+++ D+
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYK--GDDEGIFISRVSEEGPAAR-AGVRVGDK 779
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDIT 363
++EVNG L A H +AVEA + A + ++V R
Sbjct: 780 LLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE------------------------- 814
Query: 364 FEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLY 423
+M P V L PE+ S E + + E + L
Sbjct: 815 --------RMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLA 866
Query: 424 RMNSQDKLGLTVC-------YRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGI 476
R S+ LG ++ YR D GI++S I A + G ++ GDR++ ING+
Sbjct: 867 R--SERGLGFSIAGGKGSTPYRA---GDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 477 EV--QNREEAVALLTSEENKNFSLLIAR 502
+V + AV+LLT+ + +LL+ R
Sbjct: 922 DVTEARHDHAVSLLTA-ASPTIALLLER 948
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 9/111 (8%)
Query: 227 LDSLSRCVAAPPGGKGEETKSLTLVLHRDSGS-LGFNIIGG-RPSVDNHDGSSSEGIFVS 284
L L R APPG + L + + G LG +I GG R N + EGIF+S
Sbjct: 1085 LSLLVRRDPAPPGLR-------ELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFIS 1137
Query: 285 KIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQV 335
K+ +G A ++G L++ R++EVN + L TH +AV+ ++ + + V V
Sbjct: 1138 KVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 39.3 bits (90), Expect = 0.020
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Query: 441 DEDDIGIYISEIDPNSIAAKDGRIREGDRIIQIN--GIEVQNREEAVALLTS 490
D D GI+IS++ P A +DGR+R G R++++N + EAV LL S
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 91.7 bits (226), Expect = 3e-18
Identities = 99/344 (28%), Positives = 154/344 (44%), Gaps = 47/344 (13%)
Query: 156 RAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLV--AQLAAAQLELQMTA 213
RAG + L + ALQ GA H + AG + V ++ + + +T
Sbjct: 771 RAGVRVGDKLLEVNGVALQ---GAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP 827
Query: 214 LRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNH 273
LR + ++ R L R PP G + L R LGF+I GG+ S
Sbjct: 828 LRPEDDYSPRERRGGGL-RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYR 886
Query: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
G + GIFVS+I + G A + G LQ+ DR++ +NG D++ A HD AV + TA P +
Sbjct: 887 AGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAV-SLLTAASPTIA 943
Query: 334 QVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLD-PYLLPEEHPS 392
+L R + PPS T +A T +++ +P V P L P +
Sbjct: 944 LLLEREAGGPL--PPSPLPHSSPPTAA-------VATTSITTATPGVPGLPSLAPSLLAA 994
Query: 393 AHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDE------DDIG 446
A E P +EE+ L R LGL++ +D + G
Sbjct: 995 ALEGPYP-----------------VEEIRLPRAGG--PLGLSIVGGSDHSSHPFGVQEPG 1035
Query: 447 IYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN--REEAVALL 488
++IS++ P +AA+ G +R GDRI+ +NG +V++ +EAV+ L
Sbjct: 1036 VFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Score = 81.3 bits (199), Expect = 5e-15
Identities = 75/268 (27%), Positives = 119/268 (44%), Gaps = 51/268 (19%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
E + LTL + R +G LG +I GG+ S EGIF+S++ + GPAA+ G+++ D+
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYK--GDDEGIFISRVSEEGPAAR-AGVRVGDK 779
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDIT 363
++EVNG L A H +AVEA + A + ++V R
Sbjct: 780 LLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE------------------------- 814
Query: 364 FEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLY 423
+M P V L PE+ S E + + E + L
Sbjct: 815 --------RMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLA 866
Query: 424 RMNSQDKLGLTVC-------YRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGI 476
R S+ LG ++ YR D GI++S I A + G ++ GDR++ ING+
Sbjct: 867 R--SERGLGFSIAGGKGSTPYRA---GDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 477 EV--QNREEAVALLTSEENKNFSLLIAR 502
+V + AV+LLT+ + +LL+ R
Sbjct: 922 DVTEARHDHAVSLLTA-ASPTIALLLER 948
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 9/111 (8%)
Query: 227 LDSLSRCVAAPPGGKGEETKSLTLVLHRDSGS-LGFNIIGG-RPSVDNHDGSSSEGIFVS 284
L L R APPG + L + + G LG +I GG R N + EGIF+S
Sbjct: 1085 LSLLVRRDPAPPGLR-------ELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFIS 1137
Query: 285 KIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQV 335
K+ +G A ++G L++ R++EVN + L TH +AV+ ++ + + V V
Sbjct: 1138 KVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 39.3 bits (90), Expect = 0.020
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Query: 441 DEDDIGIYISEIDPNSIAAKDGRIREGDRIIQIN--GIEVQNREEAVALLTS 490
D D GI+IS++ P A +DGR+R G R++++N + EAV LL S
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 90.1 bits (222), Expect = 1e-17
Identities = 73/248 (29%), Positives = 114/248 (45%), Gaps = 31/248 (12%)
Query: 256 SGSLGFNIIGGRPSVDN-HDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSR 314
S SLG +I+GGR +G GIF+ +++ PA K G L+ DRI+EV+G DL
Sbjct: 1159 SKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRD 1218
Query: 315 ATHDQAVEAFKTAKEPIV--VQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTK 372
A+H+QAVEA + A P+V VQ + PR + + F + +
Sbjct: 1219 ASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINA 1278
Query: 373 MSSPSPPVLDP-----YLLPEEHPSAHEYYDPN---DYIGDIHQEMDREEL--------- 415
+PS +P +P PSA + I Q++D+E+
Sbjct: 1279 DKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIR 1338
Query: 416 --------ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREG 467
EL ++L + +S LGL++ D + ++I IDPN A KDGR++
Sbjct: 1339 ERYGTLTGELHMIELEKGHS--GLGLSLA-GNKDRSRMSVFIVGIDPNGAAGKDGRLQIA 1395
Query: 468 DRIIQING 475
D +++ING
Sbjct: 1396 DELLEING 1403
Score = 61.2 bits (147), Expect = 5e-09
Identities = 62/255 (24%), Positives = 100/255 (39%), Gaps = 35/255 (13%)
Query: 282 FVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPR 341
F+ ++ GP G L D ++EVNG L H V K + + RRT
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRT-- 634
Query: 342 TKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPND 401
PP+ +D+ DI P++ E + E DP
Sbjct: 635 ----VPPTTQSELDSLDLCDIELTE---------------KPHVDLGEFIGSSETEDPVL 675
Query: 402 YIGDIHQEMDREELEL-------EEVDLYRMNSQDKLGLTVCYRTDDEDDIG--IYISEI 452
+ D Q + + L + ++L + LG ++ D D I I +
Sbjct: 676 AMTDAGQSTEEVQAPLAMWEAGIQHIELEK--GSKGLGFSILDYQDPIDPASTVIIIRSL 733
Query: 453 DPNSIAAKDGRIREGDRIIQINGIEVQNR--EEAVALLTSEENKNFSLLIARP-ELQLDE 509
P IA KDGR+ GDR++ +N + ++N EEAV L + + +A+P L +E
Sbjct: 734 VPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEE 793
Query: 510 GWMDDDRNDFLDDLH 524
G++ + FL H
Sbjct: 794 GYVSAKEDSFLYPPH 808
Score = 57.4 bits (137), Expect = 7e-08
Identities = 73/300 (24%), Positives = 124/300 (41%), Gaps = 60/300 (20%)
Query: 249 TLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
T+ L D LGF IIGG+ + G+ V I+ G A + G L D I+++
Sbjct: 257 TIELVNDGSGLGFGIIGGKAT----------GVIVKTILPGGVADQHGRLCSGDHILKIG 306
Query: 309 GRDLSRATHDQAVEAFKTAKEPIVVQVLRRTP-RTKMFTPPSESQLVDTGTQTDITFEHI 367
DL+ + +Q V QVLR+ R K+ ++ G + T
Sbjct: 307 DTDLAGMSSEQ------------VAQVLRQCGNRVKL--------MIARGAIEERTAPTA 346
Query: 368 MALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNS 427
+ +T SSP+ PE A EE E +V+L + +
Sbjct: 347 LGITLSSSPTST-------PELRVDA--------------STQKGEESETFDVELTK--N 383
Query: 428 QDKLGLTVCYRTDDE--DDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NREE 483
LG+T+ D+ + GI++ I +S DGRI+ GD+II ++G +Q ++
Sbjct: 384 VQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443
Query: 484 AVALLTSEENKNFSLLIARPELQLDEGWMDDD--RNDFLDDLHMDMLEEQHHQAMQFTAS 541
AV +L L+ R Q E +D ++ L ++ +++E + + F +S
Sbjct: 444 AVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSS 503
Score = 56.6 bits (135), Expect = 1e-07
Identities = 58/266 (21%), Positives = 115/266 (43%), Gaps = 33/266 (12%)
Query: 241 KGEETKSLTLVLHRDSGSLGFNIIG--GRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGL 298
KGEE+++ + L ++ LG I G G ++ GIFV I S +G +
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE------PSGIFVKSITKSSAVEHDGRI 422
Query: 299 QIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTK------------MFT 346
QI D+II V+G +L T+ QAVE + + +++ ++RR + +
Sbjct: 423 QIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADL 482
Query: 347 PPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPY-LLPEEHPSAHEYYDPNDYIGD 405
P + ++ + D E ++ T+ ++ P + Y LL E + +
Sbjct: 483 SPVNASIIKENYEKD---EDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLT 539
Query: 406 IHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIG-IYISEIDPNSIAAKDGRI 464
Q + E+ + + + LG+++ E +G +I + P G++
Sbjct: 540 KWQRIMGINYEIVVAHVSKFSENSGLGISL------EATVGHHFIRSVLPEGPVGHSGKL 593
Query: 465 REGDRIIQINGIEV--QNREEAVALL 488
GD ++++NGI + +N ++ V +L
Sbjct: 594 FSGDELLEVNGITLLGENHQDVVNIL 619
Score = 53.5 bits (127), Expect = 1e-06
Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 25/116 (21%)
Query: 249 TLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
T+ + + LG +I+GG ++ I + ++ + G A K+G L D+I+EVN
Sbjct: 1629 TIEISKGRTGLGLSIVGGSDTLLG-------AIIIHEVYEEGAACKDGRLWAGDQILEVN 1681
Query: 309 GRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFT------PPSESQLVDTGT 358
G DL +ATHD+A + VLR+TP+ T P E ++ DT T
Sbjct: 1682 GIDLRKATHDEA------------INVLRQTPQRVRLTLYRDEAPYKEEEVCDTLT 1725
Score = 53.5 bits (127), Expect = 1e-06
Identities = 61/237 (25%), Positives = 94/237 (39%), Gaps = 57/237 (24%)
Query: 258 SLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATH 317
SLG +I GG S IF++ + +G AA+ L++ DRI+ + G TH
Sbjct: 1843 SLGISIAGGVGSP-----LGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTH 1897
Query: 318 DQAVEAFKTAKEPIVVQVLRR---TPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMS 374
QAV K A I +QV+ + T P+ S L TG + F+ +
Sbjct: 1898 TQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLG----- 1952
Query: 375 SPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLT 434
PP + + + L R D LG +
Sbjct: 1953 ---PP------------------------------------QCKSITLER--GPDGLGFS 1971
Query: 435 VCYRTDD-EDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNREEAVALL 488
+ D+ IY+ + A++DGR++ GD+II +NG +E EEAVA+L
Sbjct: 1972 IVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAIL 2028
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 7/93 (7%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
+ KS+TL R LGF+I+GG S I+V + G A+++G L+ D+
Sbjct: 1955 QCKSITL--ERGPDGLGFSIVGGYGSPHG-----DLPIYVKTVFAKGAASEDGRLKRGDQ 2007
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVL 336
II VNG+ L TH++AV K K + + VL
Sbjct: 2008 IIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/258 (24%), Positives = 104/258 (40%), Gaps = 60/258 (23%)
Query: 251 VLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGR 310
+L SG LGF+++G R + GIFV +I + A ++G L+ D+I+ +NG+
Sbjct: 140 LLKPPSGGLGFSVVGLRS-----ENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
Query: 311 DLSRA-THDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMA 369
L + TH QA+ + AK+ + + + R S QLV + I A
Sbjct: 195 ALDQTITHQQAISILQKAKDTVQLVIAR----------GSLPQLV-----SPIVSRSPSA 239
Query: 370 LTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQD 429
+ +S+ S PV Q M+ EL +N
Sbjct: 240 ASTISAHSNPV-------------------------HWQHMETIEL---------VNDGS 265
Query: 430 KLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN-REEAVALL 488
LG + G+ + I P +A + GR+ GD I++I ++ E VA +
Sbjct: 266 GLGFGII----GGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQV 321
Query: 489 TSEENKNFSLLIARPELQ 506
+ L+IAR ++
Sbjct: 322 LRQCGNRVKLMIARGAIE 339
Score = 50.1 bits (118), Expect = 1e-05
Identities = 66/287 (22%), Positives = 109/287 (37%), Gaps = 68/287 (23%)
Query: 238 PGGKGEETKSLTLVLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296
P + E +LT+ L + G LG +I+G R + G+FVS IV G A +G
Sbjct: 1714 PYKEEEVCDTLTIELQKKPGKGLGLSIVGKR---------NDTGVFVSDIVKGGIADADG 1764
Query: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356
L D+I+ VNG D+ AT
Sbjct: 1765 RLMQGDQILMVNGEDVRNATQ--------------------------------------- 1785
Query: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELE 416
E + AL K+S S L + P S E + + + E+
Sbjct: 1786 --------EAVAALLKVSEGS---LSSFTFPLSGSSTSESLESSSKKNALASEIQ----G 1830
Query: 417 LEEVDLYRMNSQDKLGLTVCYRTDDE-DDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
L V++ + D LG+++ D+ I+I+ + P +AA+ ++R GDRI+ I G
Sbjct: 1831 LRTVEM-KKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICG 1889
Query: 476 --IEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFL 520
E +AV LL + ++A ++ + G + + L
Sbjct: 1890 TSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSL 1936
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/224 (21%), Positives = 88/224 (39%), Gaps = 44/224 (19%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L + LG ++ G + S +F+ I +G A K+G LQI D ++E+NG+
Sbjct: 1353 LEKGHSGLGLSLAGNKDR-------SRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALT 371
L +H A K A + + +R D + +
Sbjct: 1406 LYGRSHQNASSIIKCAPSKVKIIFIR---------------------NKDAVNQMAVCPG 1444
Query: 372 KMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKL 431
P P + E P+ +D D+ + + LEL + Q L
Sbjct: 1445 NAVEPLPSNSENLQNKETEPTV----TTSDAAVDLSSFKNVQHLELPK-------DQGGL 1493
Query: 432 GLTVCYRTDDEDDI-GIYISEIDPNSIAAKDGRIREGDRIIQIN 474
G+ + +ED + G+ I + + +AA DGR++ GD+I+ ++
Sbjct: 1494 GIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVD 1533
Score = 44.7 bits (104), Expect = 5e-04
Identities = 55/243 (22%), Positives = 99/243 (40%), Gaps = 33/243 (13%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
L L +D G LG I + + G+ + + + G AA +G L++ D+I+ V+
Sbjct: 1484 LELPKDQGGLGIAI---------SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDD 1534
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT--GTQTDITFEHI 367
+ ++ + KTAK + + + P +SQ V + G +
Sbjct: 1535 EIVVGYPIEKFISLLKTAKMTVKLTIHAENP---------DSQAVPSAAGAASGEKKNSS 1585
Query: 368 MALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNS 427
+L S SP PE + P + D + E +
Sbjct: 1586 QSLMVPQSGSPE-------PESIRNTSRSSTPAIFASD---PATCPIIPGCETTIEISKG 1635
Query: 428 QDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NREEAV 485
+ LGL++ +D I I E+ A KDGR+ GD+I+++NGI+++ +EA+
Sbjct: 1636 RTGLGLSIVGGSDTLLG-AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
Query: 486 ALL 488
+L
Sbjct: 1695 NVL 1697
Score = 42.7 bits (99), Expect = 0.002
Identities = 67/289 (23%), Positives = 123/289 (42%), Gaps = 46/289 (15%)
Query: 219 KFTEYSARLDSLS---RCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDG 275
K +EY SL+ CV K E+ T+ + + + SLG + N DG
Sbjct: 977 KGSEYLLEQSSLACNAECVMLQNVSK--ESFERTINIAKGNSSLGMTVSA------NKDG 1028
Query: 276 SSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQV 335
G+ V I+ G +++G + I D I+ +N T+ QA + + ++
Sbjct: 1029 L---GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR--RHSLIGPD 1083
Query: 336 LRRTPRTKMFTPPS--ESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSA 393
++ T + P E + G Q+ +MAL SS + + P L E
Sbjct: 1084 IKIT-----YVPAEHLEEFKISLGQQSG----RVMALDIFSSYTGRDI-PELPEREEGEG 1133
Query: 394 HEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVC-------YRTDDEDDIG 446
E N + +Q V+L+R S+ LG+++ ++ E G
Sbjct: 1134 EESELQNTAYSNWNQP--------RRVELWREPSKS-LGISIVGGRGMGSRLSNGEVMRG 1184
Query: 447 IYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NREEAVALLTSEEN 493
I+I + +S A K+G ++ GDRI++++G++++ + E+AV + N
Sbjct: 1185 IFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGN 1233
Score = 40.4 bits (93), Expect = 0.009
Identities = 26/76 (34%), Positives = 42/76 (55%), Gaps = 4/76 (5%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L + S LGF+I+ + +D +S I + +V G A K+G L DR++ VN +
Sbjct: 703 LEKGSKGLGFSILDYQDPID----PASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVN 758
Query: 312 LSRATHDQAVEAFKTA 327
L ++ ++AVEA K A
Sbjct: 759 LENSSLEEAVEALKGA 774
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 86.7 bits (213), Expect = 1e-16
Identities = 74/254 (29%), Positives = 112/254 (44%), Gaps = 30/254 (11%)
Query: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296
PP K E K L + LGF+I GG V N I+V+KI++ G A K+G
Sbjct: 196 PPAEKVMEIK-----LIKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIEGGAAHKDG 247
Query: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356
LQI D+I+ VN L H+ AV A K + + ++V + PS + L D+
Sbjct: 248 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK----------PSNAYLSDS 297
Query: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELE 416
DIT + L S S L ++P+A P Y + E++
Sbjct: 298 YAPPDITTSYSQHLDNEISHSS------YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 351
Query: 417 LEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGI 476
E + LG + ED GI+IS I A G +R+GD+I+ +NG+
Sbjct: 352 REPRRIVIHRGSTGLGFNI---VGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 408
Query: 477 EVQN---REEAVAL 487
+++N + A+AL
Sbjct: 409 DLRNASHEQAAIAL 422
Score = 67.4 bits (163), Expect = 7e-11
Identities = 38/84 (45%), Positives = 51/84 (60%), Gaps = 9/84 (10%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+V+HR S LGFNI+GG DG EGIF+S I+ GPA G L+ D+I+ VNG
Sbjct: 357 IVIHRGSTGLGFNIVGGE------DG---EGIFISFILAGGPADLSGELRKGDQILSVNG 407
Query: 310 RDLSRATHDQAVEAFKTAKEPIVV 333
DL A+H+QA A K A + + +
Sbjct: 408 VDLRNASHEQAAIALKNAGQTVTI 431
Score = 66.2 bits (160), Expect = 2e-10
Identities = 36/91 (39%), Positives = 52/91 (57%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN IF++KI+ G AA++G L+++D I+ VN
Sbjct: 109 ITLERGNSGLGFSIAGG---TDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 165
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+ TH AVEA K A + + V+RR P
Sbjct: 166 VDVREVTHSAAVEALKEAGSIVRLYVMRRKP 196
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 5/82 (6%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
E+E EE+ L R NS LG ++ TD+ DD I+I++I P AA+DGR+R D I
Sbjct: 103 EMEYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 471 IQINGIEVQNREEAVALLTSEE 492
+ +N ++V+ + A+ +E
Sbjct: 161 LFVNEVDVREVTHSAAVEALKE 182
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 86.7 bits (213), Expect = 1e-16
Identities = 74/254 (29%), Positives = 112/254 (44%), Gaps = 30/254 (11%)
Query: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296
PP K E K L + LGF+I GG V N I+V+KI++ G A K+G
Sbjct: 150 PPAEKVMEIK-----LIKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIEGGAAHKDG 201
Query: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356
LQI D+I+ VN L H+ AV A K + + ++V + PS + L D+
Sbjct: 202 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK----------PSNAYLSDS 251
Query: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELE 416
DIT + L S S L ++P+A P Y + E++
Sbjct: 252 YAPPDITTSYSQHLDNEISHSS------YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 305
Query: 417 LEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGI 476
E + LG + ED GI+IS I A G +R+GD+I+ +NG+
Sbjct: 306 REPRRIVIHRGSTGLGFNI---VGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 362
Query: 477 EVQN---REEAVAL 487
+++N + A+AL
Sbjct: 363 DLRNASHEQAAIAL 376
Score = 67.4 bits (163), Expect = 7e-11
Identities = 38/84 (45%), Positives = 51/84 (60%), Gaps = 9/84 (10%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+V+HR S LGFNI+GG DG EGIF+S I+ GPA G L+ D+I+ VNG
Sbjct: 311 IVIHRGSTGLGFNIVGGE------DG---EGIFISFILAGGPADLSGELRKGDQILSVNG 361
Query: 310 RDLSRATHDQAVEAFKTAKEPIVV 333
DL A+H+QA A K A + + +
Sbjct: 362 VDLRNASHEQAAIALKNAGQTVTI 385
Score = 66.2 bits (160), Expect = 2e-10
Identities = 36/91 (39%), Positives = 52/91 (57%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN IF++KI+ G AA++G L+++D I+ VN
Sbjct: 63 ITLERGNSGLGFSIAGG---TDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 119
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+ TH AVEA K A + + V+RR P
Sbjct: 120 VDVREVTHSAAVEALKEAGSIVRLYVMRRKP 150
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 5/82 (6%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
E+E EE+ L R NS LG ++ TD+ DD I+I++I P AA+DGR+R D I
Sbjct: 57 EMEYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
Query: 471 IQINGIEVQNREEAVALLTSEE 492
+ +N ++V+ + A+ +E
Sbjct: 115 LFVNEVDVREVTHSAAVEALKE 136
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/239 (27%), Positives = 108/239 (45%), Gaps = 31/239 (12%)
Query: 259 LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHD 318
LGF+I GG + N I+++KI++ G A K+G LQI DR++ VN +L H+
Sbjct: 236 LGFSIAGG---IGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 292
Query: 319 QAVEAFKTAKEPIVVQVLR--RTPRTKMFTPPSESQ----LVDTGTQTDITFEHIMAL-T 371
+AV + K + + ++V + M+ PP + L D + + ++ A+ +
Sbjct: 293 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352
Query: 372 KMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKL 431
K+S P+PP + P Y P + E+ E + L
Sbjct: 353 KVSYPAPPQVPP-----------TRYSPIP-----RHMLAEEDFTREPRKIILHKGSTGL 396
Query: 432 GLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN--REEAVALL 488
G + ED GI++S I A G +R GDRI+ +NG+ ++N E+A A L
Sbjct: 397 GFNI---VGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
Score = 68.9 bits (167), Expect = 2e-11
Identities = 45/110 (40%), Positives = 59/110 (53%), Gaps = 13/110 (11%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
++LH+ S LGFNI+GG DG EGIFVS I+ GPA G L+ DRI+ VNG
Sbjct: 387 IILHKGSTGLGFNIVGGE------DG---EGIFVSFILAGGPADLSGELRRGDRILSVNG 437
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQ 359
+L ATH+QA A K A + + + R F ES++ D Q
Sbjct: 438 VNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRF----ESKIHDLREQ 483
Score = 68.2 bits (165), Expect = 4e-11
Identities = 37/91 (40%), Positives = 53/91 (58%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+VL R + LGF+I GG +DN GIF++KI+ G AA +G L ++D ++ VN
Sbjct: 132 IVLERGNSGLGFSIAGG---IDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNE 188
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+S H +AVEA K A + + V RR P
Sbjct: 189 VDVSEVVHSRAVEALKEAGPVVRLVVRRRQP 219
Score = 39.7 bits (91), Expect = 0.015
Identities = 24/64 (37%), Positives = 38/64 (59%), Gaps = 5/64 (7%)
Query: 418 EEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRIIQIN 474
EE+ L R NS LG ++ D+ DD GI+I++I P AA DGR+ D ++++N
Sbjct: 130 EEIVLERGNSG--LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 475 GIEV 478
++V
Sbjct: 188 EVDV 191
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 82.4 bits (202), Expect = 2e-15
Identities = 111/529 (20%), Positives = 198/529 (37%), Gaps = 113/529 (21%)
Query: 11 DVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLP 70
+VD DL C +C + L DPL TPCGH +C C+ ++V++ CP + + +
Sbjct: 34 EVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSIL 93
Query: 71 LKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHM 130
+ +L+ KL + C + C +V++ L H + C+ G L +D +
Sbjct: 94 VNKLLNKLLVTCPFREH-CTQVLQRCDLEHHFQ------TSCK--GASHYGLTKDRKRRS 144
Query: 131 RDACD--------ARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHK 182
+D C P + L E G A A +G Q + +
Sbjct: 145 QDGCPDGCASLTATAPSPEVSAAATISLMTDE--PGLDNPAYVSSAEDG--QPAISPVDS 200
Query: 183 ALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLD---SLSRCVAAP-- 237
+ RA E+S + + ++ ++ LR K + + D S AP
Sbjct: 201 G-RSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEV 259
Query: 238 --------PGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDS 289
P G E S+ + S SL ++GG + H I + I
Sbjct: 260 FPRLYHLIPDG---EITSIKINRVDPSESLSIRLVGGSETPLVH-------IIIQHIYRD 309
Query: 290 GPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPS 349
G A++G L D I++VNG D+S H+ AV + + + + V+R + F +
Sbjct: 310 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE----QKFRSRN 365
Query: 350 ESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQE 409
Q D D +F I+ SSP
Sbjct: 366 NGQAPDAYRPRDDSFHVIL---NKSSP--------------------------------- 389
Query: 410 MDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDR 469
+++LG+ + + D+ G++I + +A + G++ E DR
Sbjct: 390 ------------------EEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEENDR 428
Query: 470 IIQINGIEVQ-NREEAVALLTSEENKNFSLLIAR------PELQLDEGW 511
++ ING +++ E+ A L + L+++R P++ + GW
Sbjct: 429 VLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 477
Score = 60.5 bits (145), Expect = 8e-09
Identities = 53/212 (25%), Positives = 95/212 (44%), Gaps = 41/212 (19%)
Query: 280 GIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRT 339
G+F+ ++D G A + G L+ +DR++ +NG DL + + A + A E V V+ R
Sbjct: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ-ASERRVHLVVSRQ 463
Query: 340 PRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDP 399
R + E+ G+ + E S +P L P + + HE
Sbjct: 464 VRQRSPDIFQEAGWNSNGSWSPGPGER--------SNTPKPLHPTI------TCHE---- 505
Query: 400 NDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDED-DIGIYISEIDPNSIA 458
+V + + + LG+TV + D+ IY+ ++P +
Sbjct: 506 -------------------KVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 546
Query: 459 AKDGRIREGDRIIQINGIEVQ--NREEAVALL 488
++DGRI+ GD ++ ++G+E+ +R EAVALL
Sbjct: 547 SRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/88 (31%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 250 LVLHRDS-GSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
+VL R++ GSLGF I+GG + ++G ++ F+ IV+ PA +G ++ D ++ VN
Sbjct: 639 IVLRRNTAGSLGFCIVGG---YEEYNG--NKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
Query: 309 GRDLSRATHDQAVEAFKTAKEPIVVQVL 336
GR S H K K I + ++
Sbjct: 694 GRSTSGMIHACLARLLKELKGRITLTIV 721
Score = 38.9 bits (89), Expect = 0.026
Identities = 50/228 (21%), Positives = 89/228 (39%), Gaps = 47/228 (20%)
Query: 252 LHRDSG-SLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGR 310
+ +D G SLG + GG + I+V + G +++G ++ D ++ V+G
Sbjct: 510 IQKDPGESLGMTVAGGASHRE-----WDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564
Query: 311 DLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMAL 370
+L+ + +AV K IV++ L K + P +
Sbjct: 565 ELTEVSRSEAVALLKRTSSSIVLKAL----EVKEYEPQEDCS------------------ 602
Query: 371 TKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGD--IHQEMDREELELEEVDLYRMNSQ 428
SP LD S H P+D+ + E+ R +++ L R N+
Sbjct: 603 ------SPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVL-RRNTA 646
Query: 429 DKLGLTVCYRTDD-EDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
LG + ++ + +I I + A DGRIR GD ++ +NG
Sbjct: 647 GSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG 694
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 81.6 bits (200), Expect = 4e-15
Identities = 67/250 (26%), Positives = 115/250 (46%), Gaps = 23/250 (9%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L + LGF+I GG V N I+V+KI+D G A K+G LQ+ DR++ VN
Sbjct: 145 LFKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRT-----------PRTKMFTPPSESQLVDTGTQT 360
L TH++AV K E + ++V + T T ++PP E+ L+ +
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL---SGN 258
Query: 361 DITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEV 420
+ T E+ +L +S + ++L ++ ++H + + + LE E
Sbjct: 259 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQR-AVSLEGEPR 317
Query: 421 DLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ- 479
+ LG + ED GI++S I A G ++ GD+I+ +NGI+++
Sbjct: 318 KVVLHKGSTGLGFNI---VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 374
Query: 480 -NREEAVALL 488
+ E+A A L
Sbjct: 375 ASHEQAAAAL 384
Score = 70.5 bits (171), Expect = 8e-12
Identities = 44/118 (37%), Positives = 63/118 (53%), Gaps = 9/118 (7%)
Query: 229 SLSRCVAA------PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIF 282
SL +C A P G E + + L R + LGF+I GG DN GIF
Sbjct: 21 SLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGG---TDNPHIGDDPGIF 77
Query: 283 VSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
++KI+ G AA++G L+++D I+ VN D+S +H +AVEA K A + + V RR P
Sbjct: 78 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 135
Score = 68.2 bits (165), Expect = 4e-11
Identities = 43/93 (46%), Positives = 55/93 (59%), Gaps = 12/93 (12%)
Query: 241 KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
+GE K +VLH+ S LGFNI+GG DG EGIFVS I+ GPA G LQ
Sbjct: 313 EGEPRK---VVLHKGSTGLGFNIVGGE------DG---EGIFVSFILAGGPADLSGELQR 360
Query: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
D+I+ VNG DL A+H+QA A K A + + +
Sbjct: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 51.2 bits (121), Expect = 5e-06
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 5/92 (5%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
E E EE+ L R NS LG ++ TD+ DD GI+I++I P AA+DGR+R D I
Sbjct: 42 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
Query: 471 IQINGIEVQNREEAVALLTSEENKNFSLLIAR 502
+++N ++V + A+ +E + L R
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 131
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 81.3 bits (199), Expect = 5e-15
Identities = 76/263 (28%), Positives = 118/263 (44%), Gaps = 34/263 (12%)
Query: 246 KSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRII 305
K + + L + LGF+I GG V N I+V+KI++ G A K+G LQI D+++
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 306 EVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365
VN L TH++AV A K + + ++V + P+ + D DIT
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK----------PTSMYMNDGYAPPDIT-- 420
Query: 366 HIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDP--NDYIGDIHQEMDREELELEEVDLY 423
S P + P + P++ Y P +GD E+ RE +V L+
Sbjct: 421 -----NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGD--DEITREP---RKVVLH 470
Query: 424 RMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NR 481
R LG + ED GI+IS I A G +R+GDRII +N ++++ +
Sbjct: 471 R--GSTGLGFNI---VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 482 EEAVALLTSEENKNFSLLIARPE 504
E+A A L + + RPE
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPE 548
Score = 65.5 bits (158), Expect = 3e-10
Identities = 36/91 (39%), Positives = 52/91 (57%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN IF++KI+ G AA++G L+++D I+ VN
Sbjct: 225 ITLERGNSGLGFSIAGG---TDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+ TH +AVEA K A + + V RR P
Sbjct: 282 VDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 5/103 (4%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
+ E EE+ L R NS LG ++ TD+ DD I+I++I AA+DGR+R D I
Sbjct: 219 DYEYEEITLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 471 IQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMD 513
+++N ++V++ + A+ +E + L + + E M+
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIME 319
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 81.3 bits (199), Expect = 5e-15
Identities = 76/263 (28%), Positives = 118/263 (44%), Gaps = 34/263 (12%)
Query: 246 KSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRII 305
K + + L + LGF+I GG V N I+V+KI++ G A K+G LQI D+++
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 306 EVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365
VN L TH++AV A K + + ++V + P+ + D DIT
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK----------PTSMYMNDGYAPPDIT-- 420
Query: 366 HIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDP--NDYIGDIHQEMDREELELEEVDLY 423
S P + P + P++ Y P +GD E+ RE +V L+
Sbjct: 421 -----NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGD--DEITREP---RKVVLH 470
Query: 424 RMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NR 481
R LG + ED GI+IS I A G +R+GDRII +N ++++ +
Sbjct: 471 R--GSTGLGFNI---VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 482 EEAVALLTSEENKNFSLLIARPE 504
E+A A L + + RPE
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPE 548
Score = 65.5 bits (158), Expect = 3e-10
Identities = 36/91 (39%), Positives = 52/91 (57%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN IF++KI+ G AA++G L+++D I+ VN
Sbjct: 225 ITLERGNSGLGFSIAGG---TDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+ TH +AVEA K A + + V RR P
Sbjct: 282 VDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 5/103 (4%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
+ E EE+ L R NS LG ++ TD+ DD I+I++I AA+DGR+R D I
Sbjct: 219 DYEYEEITLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 471 IQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMD 513
+++N ++V++ + A+ +E + L + + E M+
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIME 319
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 77.4 bits (189), Expect = 7e-14
Identities = 76/282 (26%), Positives = 125/282 (44%), Gaps = 48/282 (17%)
Query: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296
P GG S +++ + LGF+I+GG+ S+ GI+V I G AA +G
Sbjct: 205 PSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-----YGPIGIYVKTIFAGGAAAADG 259
Query: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLV-- 354
LQ D I+E+NG ++ TH A++ FK AK+ + L T RT++ PPS +
Sbjct: 260 RLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL----LTLTVRTRLTAPPSLCSHLSP 315
Query: 355 ----DTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEM 410
+ T IT + + + SPS P+ PN I
Sbjct: 316 PLCRSLSSSTCITKD--SSSFALESPSAPI--------------STAKPNYRI------- 352
Query: 411 DREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRI 470
+ EV L + + LG+ +C + GI++ + P S+A DGR+R GD I
Sbjct: 353 ------MVEVSLQK-EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEI 405
Query: 471 IQINGIEVQ--NREEAVALLTSEENKNFSLLIAR-PELQLDE 509
++I+ V E +L+ + ++++R P+ Q+ E
Sbjct: 406 VEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 10/118 (8%)
Query: 251 VLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+LH++ G+ LGF++ GG ++ I V ++ +G A++EG +Q + ++ +NG
Sbjct: 1115 ILHKEEGAGLGFSLAGGADL-------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
Query: 310 RDLSRATHDQAVEAFKTAKEP--IVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365
+ L TH A+ + A+EP V+ + TP S +D++ E
Sbjct: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
Score = 35.4 bits (80), Expect = 0.29
Identities = 18/74 (24%), Positives = 42/74 (56%), Gaps = 3/74 (4%)
Query: 431 LGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNREEAVALL 488
LG ++ D E+ + I + + PN +A+++G I++G+ ++ ING ++ +A+A+L
Sbjct: 1124 LGFSLAGGADLENKV-ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAIL 1182
Query: 489 TSEENKNFSLLIAR 502
++++ R
Sbjct: 1183 RQAREPRQAVIVTR 1196
Score = 34.3 bits (77), Expect = 0.64
Identities = 23/109 (21%), Positives = 51/109 (46%), Gaps = 6/109 (5%)
Query: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
E T+ L + S LGF++ GG+ S+ + + +++I + + +Q D
Sbjct: 1229 EATVCTVTLEKMSAGLGFSLEGGKGSL-----HGDKPLTINRIFKGAASEQSETVQPGDE 1283
Query: 304 IIEVNGRDLSRATHDQAVEAFKTAKE-PIVVQVLRRTPRTKMFTPPSES 351
I+++ G + T +A K + P+ + + R++ ++K T +S
Sbjct: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 75.9 bits (185), Expect = 2e-13
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 6/124 (4%)
Query: 17 KCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARC---RGRLSAKELNHVLPLKR 73
KCA CH VL +P T CGH FC C+L ++E + C + + ++E+ KR
Sbjct: 44 KCAFCHSVLHNPHQTGCGHRFCQHCILS--LRELNTVPICPVDKEVIKSQEVFKDNCCKR 101
Query: 74 LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDA 133
+L L + C+ A GC V L + +HL++C F P +C + C + +LR+D++ H+ +
Sbjct: 102 EVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS 160
Query: 134 CDAR 137
C R
Sbjct: 161 CQFR 164
Score = 30.8 bits (68), Expect = 7.1
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%)
Query: 84 YATRGCGRVVKLQQLPEHLERCDFAPARC--RHAGCGQVLLRRDVEAHMRDA 133
+ C +++ ++ EHL C A C +H GC RR+++ H A
Sbjct: 194 FCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSA 245
>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 75.9 bits (185), Expect = 2e-13
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 6/124 (4%)
Query: 17 KCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARC---RGRLSAKELNHVLPLKR 73
KCA CH VL +P T CGH FC C+L ++E + C + + ++E+ KR
Sbjct: 44 KCAFCHSVLHNPHQTGCGHRFCQHCILS--LRELNTVPICPVDKEVIKSQEVFKDNCCKR 101
Query: 74 LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDA 133
+L L + C+ A GC V L + +HL++C F P +C + C + +LR+D++ H+ +
Sbjct: 102 EVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS 160
Query: 134 CDAR 137
C R
Sbjct: 161 CQFR 164
Score = 30.8 bits (68), Expect = 7.1
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%)
Query: 84 YATRGCGRVVKLQQLPEHLERCDFAPARC--RHAGCGQVLLRRDVEAHMRDA 133
+ C +++ ++ EHL C A C +H GC RR+++ H A
Sbjct: 194 FCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSA 245
>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 75.9 bits (185), Expect = 2e-13
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 6/124 (4%)
Query: 17 KCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARC---RGRLSAKELNHVLPLKR 73
KCA CH VL +P T CGH FC C+L ++E + C + + ++E+ KR
Sbjct: 44 KCAFCHSVLHNPHQTGCGHRFCQHCILS--LRELNTVPICPVDKEVIKSQEVFKDNCCKR 101
Query: 74 LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDA 133
+L L + C+ A GC V L + +HL++C F P +C + C + +LR+D++ H+ +
Sbjct: 102 EVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS 160
Query: 134 CDAR 137
C R
Sbjct: 161 CQFR 164
Score = 30.8 bits (68), Expect = 7.1
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%)
Query: 84 YATRGCGRVVKLQQLPEHLERCDFAPARC--RHAGCGQVLLRRDVEAHMRDA 133
+ C +++ ++ EHL C A C +H GC RR+++ H A
Sbjct: 194 FCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSA 245
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 74.3 bits (181), Expect = 6e-13
Identities = 82/335 (24%), Positives = 131/335 (39%), Gaps = 57/335 (17%)
Query: 5 LDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKE 64
L + +VD DL C +C + L PL TPCGH FC C+ ++ ++ CP
Sbjct: 37 LYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCP----------- 85
Query: 65 LNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRR 124
L KRL KL K + ++ + L + L C F+ C V+ R
Sbjct: 86 ----LDRKRLHFKLCKKSS--------ILVHKLLDKLLVLCPFSSV------CKDVMQRC 127
Query: 125 DVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKAL 184
D+EAH+++ C G L E+R A + L G L
Sbjct: 128 DLEAHLKNRCP----GASHRRVAL-----ERRKTSRTQAEIENENGPTLLDPAGTL---- 174
Query: 185 KKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEE 244
EA G + L +A L E SA D+ + ++ P G
Sbjct: 175 SPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEG----- 229
Query: 245 TKSLTLVLHRDSG--SLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHD 302
+ T+ +HR + LG +I+GG + I + ++ G A++G L D
Sbjct: 230 -EITTIEIHRSNPYIQLGISIVGGNET-------PLINIVIQEVYRDGVIARDGRLLAGD 281
Query: 303 RIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLR 337
+I++VN ++S +H+ A + + VLR
Sbjct: 282 QILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLR 316
Score = 72.0 bits (175), Expect = 3e-12
Identities = 62/244 (25%), Positives = 113/244 (46%), Gaps = 49/244 (20%)
Query: 250 LVLH-RDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEV 307
+ LH RDSG LG ++ + G+F+ +++ G AA++G L +DR++ +
Sbjct: 340 VALHKRDSGEQLGIKLVRR---------TDEPGVFILDLLEGGLAAQDGRLSSNDRVLAI 390
Query: 308 NGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHI 367
NG DL T + A + + + E + + + R P + + + G + + H
Sbjct: 391 NGHDLKYGTPELAAQIIQASGERVNLTIARPG------KPQPGNTIREAGNHSSSSQHH- 443
Query: 368 MALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNS 427
+PP PY PS+H+ D+ Q + +E + +
Sbjct: 444 ---------TPP---PYY---SRPSSHK---------DLTQCVTCQEKHI----TVKKEP 475
Query: 428 QDKLGLTVC-YRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN--REEA 484
+ LG+TV R ++ I+++ + P+ A+DGRI+ GD ++ INGI++ N EA
Sbjct: 476 HESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEA 535
Query: 485 VALL 488
VA+L
Sbjct: 536 VAML 539
Score = 53.9 bits (128), Expect = 8e-07
Identities = 29/98 (29%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 407 HQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIRE 466
H + + E+ +V L++ +S ++LG+ + RTD+ G++I ++ +AA+DGR+
Sbjct: 327 HSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP---GVFILDLLEGGLAAQDGRLSS 383
Query: 467 GDRIIQINGIEVQ-NREEAVALLTSEENKNFSLLIARP 503
DR++ ING +++ E A + + +L IARP
Sbjct: 384 NDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
Score = 46.2 bits (108), Expect = 2e-04
Identities = 59/250 (23%), Positives = 94/250 (37%), Gaps = 45/250 (18%)
Query: 258 SLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATH 317
SLG + GGR S S IFV+ + G A++G ++ D ++ +NG DL+ +H
Sbjct: 478 SLGMTVAGGRGSK-----SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSH 532
Query: 318 DQAVEAFK-TAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSP 376
+AV K +A P V E Q+V+ TQ + + +
Sbjct: 533 SEAVAMLKASAASPAVA------------LKALEVQIVEEATQNAEEQPSTFSENEYDAS 580
Query: 377 SPPVLDPYL-LPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTV 435
P +L LP S H+ Y+G V Y N ++
Sbjct: 581 WSPSWVMWLGLPSTLHSCHDIVLRRSYLG---------SWGFSIVGGYEENHTNQ----- 626
Query: 436 CYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEV--QNREEAVALLTSEEN 493
+I I + A DGR++ GD I+ +NG+ + V +L + N
Sbjct: 627 ----------PFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRN 676
Query: 494 KNFSLLIARP 503
K +I P
Sbjct: 677 KVTLTVICWP 686
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/73 (28%), Positives = 42/73 (57%), Gaps = 1/73 (1%)
Query: 408 QEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREG 467
Q + E E+ ++++R N +LG+++ ++ I I I E+ + + A+DGR+ G
Sbjct: 222 QPLSLPEGEITTIEIHRSNPYIQLGISIV-GGNETPLINIVIQEVYRDGVIARDGRLLAG 280
Query: 468 DRIIQINGIEVQN 480
D+I+Q+N + N
Sbjct: 281 DQILQVNNYNISN 293
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 73.9 bits (180), Expect = 7e-13
Identities = 79/301 (26%), Positives = 125/301 (41%), Gaps = 73/301 (24%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L + LGF+I GG V N I+V+KI+D G A K+G LQ+ DR++ VN
Sbjct: 301 LFKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 357
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRT-----------PRTKMFTPPSESQLVDTGTQT 360
L TH++AV K E + ++V + T T ++PP E+ L+ +
Sbjct: 358 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL---SGN 414
Query: 361 DITFEHIMALTKMS----SPSPP---VLDPYLLPEE-----------HPSAHEYYDPND- 401
+ T E+ +L +S SP P V D Y P E P++ +Y P +
Sbjct: 415 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 474
Query: 402 -------------YIGDI----------HQEMDRE---------ELELEEVDLYRMNSQD 429
++G + H R+ LE E +
Sbjct: 475 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 534
Query: 430 KLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NREEAVAL 487
LG + ED GI++S I A G ++ GD+I+ +NGI+++ + E+A A
Sbjct: 535 GLGFNI---VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAA 591
Query: 488 L 488
L
Sbjct: 592 L 592
Score = 68.6 bits (166), Expect = 3e-11
Identities = 37/91 (40%), Positives = 54/91 (59%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN GIF++KI+ G AA++G L+++D I+ VN
Sbjct: 204 ITLERGNSGLGFSIAGG---TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNE 260
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+S +H +AVEA K A + + V RR P
Sbjct: 261 VDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 291
Score = 68.2 bits (165), Expect = 4e-11
Identities = 43/93 (46%), Positives = 55/93 (59%), Gaps = 12/93 (12%)
Query: 241 KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
+GE K +VLH+ S LGFNI+GG DG EGIFVS I+ GPA G LQ
Sbjct: 521 EGEPRK---VVLHKGSTGLGFNIVGGE------DG---EGIFVSFILAGGPADLSGELQR 568
Query: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
D+I+ VNG DL A+H+QA A K A + + +
Sbjct: 569 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 601
Score = 51.2 bits (121), Expect = 5e-06
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 5/92 (5%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
E E EE+ L R NS LG ++ TD+ DD GI+I++I P AA+DGR+R D I
Sbjct: 198 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 255
Query: 471 IQINGIEVQNREEAVALLTSEENKNFSLLIAR 502
+++N ++V + A+ +E + L R
Sbjct: 256 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 287
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/52 (44%), Positives = 33/52 (63%), Gaps = 4/52 (7%)
Query: 444 DIGIYISEIDPNSIAAKDGRIREGDRIIQIN--GIEVQNREEAVALL--TSE 491
D IY+++I A KDGR++ GDR++ +N +E EEAVA+L TSE
Sbjct: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSE 375
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 73.9 bits (180), Expect = 7e-13
Identities = 79/301 (26%), Positives = 125/301 (41%), Gaps = 73/301 (24%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L + LGF+I GG V N I+V+KI+D G A K+G LQ+ DR++ VN
Sbjct: 196 LFKGPKGLGFSIAGG---VGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 252
Query: 312 LSRATHDQAVEAFKTAKEPIVVQVLRRT-----------PRTKMFTPPSESQLVDTGTQT 360
L TH++AV K E + ++V + T T ++PP E+ L+ +
Sbjct: 253 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL---SGN 309
Query: 361 DITFEHIMALTKMS----SPSPP---VLDPYLLPEE-----------HPSAHEYYDPND- 401
+ T E+ +L +S SP P V D Y P E P++ +Y P +
Sbjct: 310 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 369
Query: 402 -------------YIGDI----------HQEMDRE---------ELELEEVDLYRMNSQD 429
++G + H R+ LE E +
Sbjct: 370 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 429
Query: 430 KLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NREEAVAL 487
LG + ED GI++S I A G ++ GD+I+ +NGI+++ + E+A A
Sbjct: 430 GLGFNI---VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAA 486
Query: 488 L 488
L
Sbjct: 487 L 487
Score = 68.6 bits (166), Expect = 3e-11
Identities = 37/91 (40%), Positives = 54/91 (59%), Gaps = 3/91 (3%)
Query: 250 LVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
+ L R + LGF+I GG DN GIF++KI+ G AA++G L+++D I+ VN
Sbjct: 99 ITLERGNSGLGFSIAGG---TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNE 155
Query: 310 RDLSRATHDQAVEAFKTAKEPIVVQVLRRTP 340
D+S +H +AVEA K A + + V RR P
Sbjct: 156 VDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 186
Score = 68.2 bits (165), Expect = 4e-11
Identities = 43/93 (46%), Positives = 55/93 (59%), Gaps = 12/93 (12%)
Query: 241 KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI 300
+GE K +VLH+ S LGFNI+GG DG EGIFVS I+ GPA G LQ
Sbjct: 416 EGEPRK---VVLHKGSTGLGFNIVGGE------DG---EGIFVSFILAGGPADLSGELQR 463
Query: 301 HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333
D+I+ VNG DL A+H+QA A K A + + +
Sbjct: 464 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 496
Score = 51.2 bits (121), Expect = 5e-06
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 5/92 (5%)
Query: 414 ELELEEVDLYRMNSQDKLGLTVCYRTDDE---DDIGIYISEIDPNSIAAKDGRIREGDRI 470
E E EE+ L R NS LG ++ TD+ DD GI+I++I P AA+DGR+R D I
Sbjct: 93 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 150
Query: 471 IQINGIEVQNREEAVALLTSEENKNFSLLIAR 502
+++N ++V + A+ +E + L R
Sbjct: 151 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 182
Score = 40.4 bits (93), Expect = 0.009
Identities = 23/52 (44%), Positives = 33/52 (63%), Gaps = 4/52 (7%)
Query: 444 DIGIYISEIDPNSIAAKDGRIREGDRIIQIN--GIEVQNREEAVALL--TSE 491
D IY+++I A KDGR++ GDR++ +N +E EEAVA+L TSE
Sbjct: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSE 270
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/122 (40%), Positives = 64/122 (52%), Gaps = 15/122 (12%)
Query: 238 PGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGG 297
PGG E + + +LH+ S LGFNI+GG DG EGIFVS I+ GPA G
Sbjct: 40 PGGDAREPRKI--ILHKGSTGLGFNIVGGE------DG---EGIFVSFILAGGPADLSGE 88
Query: 298 LQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTG 357
L+ DRI+ VNG +L ATH+QA A K A + + + R F ES++ D
Sbjct: 89 LRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRF----ESKIHDLR 144
Query: 358 TQ 359
Q
Sbjct: 145 EQ 146
Score = 38.1 bits (87), Expect = 0.045
Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 442 EDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQN--REEAVALL 488
ED GI++S I A G +R GDRI+ +NG+ ++N E+A A L
Sbjct: 67 EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 115
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 72.0 bits (175), Expect = 3e-12
Identities = 74/261 (28%), Positives = 120/261 (45%), Gaps = 43/261 (16%)
Query: 235 AAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAK 294
+A PG E + ++L + LGF+I GG GI+VS +V+ G A+
Sbjct: 132 SAGPG----EVRLVSLRRAKAHEGLGFSIRGG--------SEHGVGIYVS-LVEPGSLAE 178
Query: 295 EGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLV 354
+ GL++ D+I+ VN + L+R TH +AV+A K +K K+ + +
Sbjct: 179 KEGLRVGDQILRVNDKSLARVTHAEAVKALKGSK--------------KLVLSVYSAGRI 224
Query: 355 DTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREE 414
G T+ + + + SP P LP+ H A + D +H +E
Sbjct: 225 PGGYVTNHIYTWVDPQGRSISP------PSGLPQPHGGALRQQE-GDRRSTLHLLQGGDE 277
Query: 415 LELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQIN 474
++ V + LGLT+ R E +GIYI+ +DP S A G ++ GD+I+++N
Sbjct: 278 KKVNLV----LGDGRSLGLTI--RGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVN 330
Query: 475 GIEVQN--REEAVALLTSEEN 493
G N +EAV LL S +
Sbjct: 331 GRSFLNILHDEAVRLLKSSRH 351
Score = 51.6 bits (122), Expect = 4e-06
Identities = 64/246 (26%), Positives = 101/246 (41%), Gaps = 29/246 (11%)
Query: 115 AGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQ 174
AG G+V L A + G + G G+ ++ E G LR + L+
Sbjct: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEP--GSLAEKEGLRVGDQILR 190
Query: 175 ARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCV 234
+L + EA++A K K LV + +A + + + R S +
Sbjct: 191 VNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGL 250
Query: 235 AAPPGG----------------KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSS 278
P GG +G + K + LVL D SLG I GG
Sbjct: 251 PQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLG-DGRSLGLTIRGG--------AEYG 301
Query: 279 EGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIV-VQVLR 337
GI+++ VD G A+ GL++ D+I+EVNGR HD+AV K+++ I+ V+ +
Sbjct: 302 LGIYITG-VDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 360
Query: 338 RTPRTK 343
R P +
Sbjct: 361 RLPHAR 366
>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 72.0 bits (175), Expect = 3e-12
Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 1/133 (0%)
Query: 6 DRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKEL 65
++F V+ KC CH VL P T CGH FC C+ + C+ + ++
Sbjct: 41 EKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKV 100
Query: 66 NHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLER-CDFAPARCRHAGCGQVLLRR 124
KR IL L I C +RGC + L L HL+ C F C C + +LR+
Sbjct: 101 FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK 160
Query: 125 DVEAHMRDACDAR 137
D+ H+ AC R
Sbjct: 161 DLRDHVEKACKYR 173
>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
sapiens]
Length = 543
Score = 72.0 bits (175), Expect = 3e-12
Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 1/133 (0%)
Query: 6 DRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKEL 65
++F V+ KC CH VL P T CGH FC C+ + C+ + ++
Sbjct: 41 EKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKV 100
Query: 66 NHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLER-CDFAPARCRHAGCGQVLLRR 124
KR IL L I C +RGC + L L HL+ C F C C + +LR+
Sbjct: 101 FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK 160
Query: 125 DVEAHMRDACDAR 137
D+ H+ AC R
Sbjct: 161 DLRDHVEKACKYR 173
>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 72.0 bits (175), Expect = 3e-12
Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 1/133 (0%)
Query: 6 DRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKEL 65
++F V+ KC CH VL P T CGH FC C+ + C+ + ++
Sbjct: 41 EKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKV 100
Query: 66 NHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLER-CDFAPARCRHAGCGQVLLRR 124
KR IL L I C +RGC + L L HL+ C F C C + +LR+
Sbjct: 101 FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK 160
Query: 125 DVEAHMRDACDAR 137
D+ H+ AC R
Sbjct: 161 DLRDHVEKACKYR 173
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 67.8 bits (164), Expect = 5e-11
Identities = 70/269 (26%), Positives = 117/269 (43%), Gaps = 38/269 (14%)
Query: 252 LHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGR 310
L+++ G LGF+I GGR + GIFV I +G AA++G L+ D I++VNG
Sbjct: 589 LYKEKGKGLGFSIAGGRDCI-----RGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
Query: 311 DLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMAL 370
+ T +A+ FK + + V T RTK+ +P L T T ++
Sbjct: 644 PIKGLTFQEAIHTFKQIRSGLFV----LTVRTKLVSP----SLTPCSTPTHMSRSASPNF 695
Query: 371 TKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDK 430
S D E S+ P DR +E+ +N + +
Sbjct: 696 NTSGGASAGGSD-----EGSSSSLGRKTPG--------PKDRIVMEV------TLNKEPR 736
Query: 431 LGLTV--CYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNR--EEAVA 486
+GL + C + GIYI + P S+A + + GD+I+++N + V++ + A
Sbjct: 737 VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHA 796
Query: 487 LLTSEENKNFSLLIAR-PELQLDEGWMDD 514
+L+ L+I R P ++ E MD+
Sbjct: 797 ILSKCPPGPVRLVIGRHPNPKVSEQEMDE 825
Score = 43.9 bits (102), Expect = 8e-04
Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 18/120 (15%)
Query: 252 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 311
L ++S LG + GGR S S I V+++ + G A ++G L + D ++ +NG
Sbjct: 337 LLKESDGLGIQVSGGRGSK-----RSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
Query: 312 LSRATHDQAVEAFKTA----------KEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTD 361
L +H++AV ++A KE +LR T ++ P S + D + TD
Sbjct: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKS---LPDLTSSVEDVSSWTD 448
Score = 38.9 bits (89), Expect = 0.026
Identities = 41/168 (24%), Positives = 70/168 (41%), Gaps = 11/168 (6%)
Query: 425 MNSQDKLGLTVCY-RTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNR 481
+ D LG+ V R I ++++ A +DGR+ GD ++ ING + +
Sbjct: 338 LKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSH 397
Query: 482 EEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTAS 541
EEAVA+L S L++A E ++ L + L +T +
Sbjct: 398 EEAVAILRSATGM-VQLVVASKENSAEDLLR-------LTSKSLPDLTSSVEDVSSWTDN 449
Query: 542 VLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENN 589
Q+ +ED GT+ + ++ V +ES N ES +Q +N
Sbjct: 450 EDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSN 497
Score = 37.4 bits (85), Expect = 0.076
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 11/88 (12%)
Query: 250 LVLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
+VL+R GS LGF++ GG + I V ++ G A++EG + D ++ VN
Sbjct: 2623 IVLNRKEGSGLGFSVAGG-------TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675
Query: 309 GRDLSRATHDQAVEAFKTA---KEPIVV 333
G L+ H ++ A K+ +VV
Sbjct: 2676 GASLAGLAHGNVLKVLHQAQLHKDALVV 2703
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 5/88 (5%)
Query: 735 VRRHELSDITELPEKS-DKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAEGISCPSSEG 793
V R +L ++ L DK S Y+ G S LEI+P S A G+SCP G
Sbjct: 2477 VSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGG 2536
Query: 794 AVGTTEAYGPASKNLLSITEDPEVGTPT 821
GP + S E P + T
Sbjct: 2537 NRACPGGSGPKT----SAAETPSSASDT 2560
Score = 31.6 bits (70), Expect = 4.2
Identities = 14/33 (42%), Positives = 23/33 (69%), Gaps = 1/33 (3%)
Query: 444 DIG-IYISEIDPNSIAAKDGRIREGDRIIQING 475
D+G I+++E+ NS A K G++R D I+ +NG
Sbjct: 115 DVGCIWVTELRKNSPAGKSGKVRLRDEILSLNG 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,419,606
Number of Sequences: 37866
Number of extensions: 2148120
Number of successful extensions: 10218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 337
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 8697
Number of HSP's gapped (non-prelim): 1513
length of query: 1066
length of database: 18,247,518
effective HSP length: 113
effective length of query: 953
effective length of database: 13,968,660
effective search space: 13312132980
effective search space used: 13312132980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.