Guide to the Human Genome
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Search of human proteins with 55750041

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55750041 atrophin-1 [Homo sapiens]
         (1190 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55750053 atrophin-1 [Homo sapiens]                                2481   0.0  
gi|55750041 atrophin-1 [Homo sapiens]                                2481   0.0  
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         709   0.0  
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         709   0.0  
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         709   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   162   1e-39
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   155   3e-37
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]        129   2e-29
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   125   2e-28
gi|160707881 formin 2 [Homo sapiens]                                  124   5e-28
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   122   2e-27
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]            119   1e-26
gi|47132519 Ras association and pleckstrin homology domains 1 is...   119   2e-26
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                  117   7e-26
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                  117   7e-26
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  117   7e-26
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   117   7e-26
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]        116   1e-25
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   115   2e-25
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    114   6e-25
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   111   5e-24
gi|150170670 piccolo isoform 2 [Homo sapiens]                         108   4e-23
gi|150378539 piccolo isoform 1 [Homo sapiens]                         108   4e-23
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ...   107   5e-23
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...   102   2e-21
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ...   102   2e-21
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]             102   3e-21
gi|112421108 capicua homolog [Homo sapiens]                           101   5e-21
gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]    100   8e-21
gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]    100   8e-21

>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 2481 bits (6429), Expect = 0.0
 Identities = 1190/1190 (100%), Positives = 1190/1190 (100%)

Query: 1    MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE 60
            MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE
Sbjct: 1    MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE 60

Query: 61   EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD 120
            EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD
Sbjct: 61   EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD 120

Query: 121  PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE 180
            PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE
Sbjct: 121  PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE 180

Query: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA 240
            ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA
Sbjct: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA 240

Query: 241  ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN 300
            ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN
Sbjct: 241  ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN 300

Query: 301  LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP 360
            LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP
Sbjct: 301  LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP 360

Query: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV 420
            PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV
Sbjct: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV 420

Query: 421  SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH 480
            SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH
Sbjct: 421  SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH 480

Query: 481  HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540
            HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR
Sbjct: 481  HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540

Query: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600
            PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP
Sbjct: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600

Query: 601  FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
            FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG
Sbjct: 601  FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660

Query: 661  SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720
            SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP
Sbjct: 661  SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720

Query: 721  LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS 780
            LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS
Sbjct: 721  LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS 780

Query: 781  DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK 840
            DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK
Sbjct: 781  DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK 840

Query: 841  LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR 900
            LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR
Sbjct: 841  LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR 900

Query: 901  NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL 960
            NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL
Sbjct: 901  NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL 960

Query: 961  HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER 1020
            HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER
Sbjct: 961  HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER 1020

Query: 1021 LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI 1080
            LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI
Sbjct: 1021 LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI 1080

Query: 1081 DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL 1140
            DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL
Sbjct: 1081 DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL 1140

Query: 1141 QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190
            QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
Sbjct: 1141 QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 2481 bits (6429), Expect = 0.0
 Identities = 1190/1190 (100%), Positives = 1190/1190 (100%)

Query: 1    MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE 60
            MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE
Sbjct: 1    MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVE 60

Query: 61   EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD 120
            EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD
Sbjct: 61   EASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSD 120

Query: 121  PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE 180
            PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE
Sbjct: 121  PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPE 180

Query: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA 240
            ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA
Sbjct: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGA 240

Query: 241  ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN 300
            ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN
Sbjct: 241  ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN 300

Query: 301  LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP 360
            LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP
Sbjct: 301  LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP 360

Query: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV 420
            PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV
Sbjct: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV 420

Query: 421  SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH 480
            SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH
Sbjct: 421  SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH 480

Query: 481  HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540
            HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR
Sbjct: 481  HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540

Query: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600
            PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP
Sbjct: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600

Query: 601  FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
            FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG
Sbjct: 601  FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660

Query: 661  SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720
            SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP
Sbjct: 661  SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720

Query: 721  LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS 780
            LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS
Sbjct: 721  LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARS 780

Query: 781  DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK 840
            DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK
Sbjct: 781  DLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVK 840

Query: 841  LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR 900
            LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR
Sbjct: 841  LAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNR 900

Query: 901  NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL 960
            NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL
Sbjct: 901  NHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPL 960

Query: 961  HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER 1020
            HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER
Sbjct: 961  HGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAER 1020

Query: 1021 LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI 1080
            LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI
Sbjct: 1021 LAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLI 1080

Query: 1081 DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL 1140
            DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL
Sbjct: 1081 DPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQL 1140

Query: 1141 QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190
            QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL
Sbjct: 1141 QAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  709 bits (1830), Expect = 0.0
 Identities = 451/937 (48%), Positives = 531/937 (56%), Gaps = 126/937 (13%)

Query: 298  TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH 357
            +P++P P      +++SA    L AQP    L +P  +       PPG  + PT  P+P 
Sbjct: 158  SPSIPSPQDNESDSDSSAQQQMLQAQPPA--LQAPTGVTPAPSSAPPGTPQLPTPGPTP- 214

Query: 358  SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
                  S+   PP   P +S + +   A ++    +            P  PH  P P  
Sbjct: 215  ------SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHP-- 266

Query: 418  LSVSNQPPKYT------QPSLPSQA---VWSQGPPPPPPY--GRLLANSNAHPGP----- 461
               S  PP         QPS PS A   +  QGPP P     G LL     HPGP     
Sbjct: 267  ---SPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ----HPGPPQPFG 319

Query: 462  FPP--STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPL 519
             PP  S G       P + + H   Q    Q   Q QQ  ++Q      PP P A PH  
Sbjct: 320  LPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPL----PPAPLAMPH-- 373

Query: 520  EGGSSHHAHPYAMSPSLGSLRPYPPGP-AHLPPPH--SQVSYSQAGPNGPPVSSSSNSSS 576
                        + P   +  P  P P AH  PPH      +S      PP +    SS 
Sbjct: 374  ------------IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSL 421

Query: 577  STSQGSYPCSHPSPSQ-GPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPG 635
            ST     P +HP P Q  PQ  P P  P                   + P G   +    
Sbjct: 422  STHHP--PSAHPPPLQLMPQSQPLPSSP-------------------AQPPGLTQSQNLP 460

Query: 636  PPPYGKRAPSPGAYKTATPPGYK-----PGSPPSFRTGTPPGYRGTS-PPAGPGTFKPGS 689
            PPP     P  G ++ A  P +      PG PP     TPP    TS PPAGPGT     
Sbjct: 461  PPPASH--PPTGLHQVAPQPPFAQHPFVPGGPPPI---TPPTCPSTSTPPAGPGTS---- 511

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSP 749
                  P   A  SG         A  S  PL   QIK+E  ++ E PESP PP RSPSP
Sbjct: 512  ---AQPPCSGAAASG------GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSP 562

Query: 750  PPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQ 809
             P VVD PSHASQSARF KHLDRG+NSCAR+DLYF+PL GSKLAKKR + +EK +REAEQ
Sbjct: 563  EPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQ 622

Query: 810  RAREEKEREREREREKEREREKERELERSVKL---AQEGRAPVECPSL-GPVPHRPPFE- 864
            +AREE+ERE+E+E+E+ERERE+ERE ER+ K    A EGR  +  P L GP   RP FE 
Sbjct: 623  KAREEREREKEKEKEREREREREREAERAAKASSSAHEGR--LSDPQLSGPGHMRPSFEP 680

Query: 865  PGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALY 924
            P + +A VPPY+GPDTPALRTLSEYARPHVMSP NRNHPFY+PL   DP LL Y++P LY
Sbjct: 681  PPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDP-LLAYHMPGLY 739

Query: 925  SSDPAARE--------REREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGG 976
            + DP  RE        RERE RER+LR+R+KPGFEVKP EL+PLH    P ++ F RH  
Sbjct: 740  NVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANP-MEHFARHSA 798

Query: 977  LALQPGPPGLHPF-PFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALG 1035
            L + P   G HPF  FHP L PLERERLAL AGP LRP+MSY +RLAAER HAER+A+L 
Sbjct: 799  LTIPP-TAGPHPFASFHPGLNPLERERLAL-AGPQLRPEMSYPDRLAAERIHAERMASLT 856

Query: 1036 NDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASAS-VHPLIDPLASGSHLTRIPY 1094
            +DPLARLQM NVTPHHHQHSHIHSHLHLHQQD +H  SA  VHPL+DPL +G HL R PY
Sbjct: 857  SDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPY 916

Query: 1095 PAGTLPNPLLPHPLHENEVLRHQLFAAPY-RDLPASLSAPMSAAHQLQAMHAQSAELQRL 1153
            P GTLPNPLL  P HE+E+LRH +F  PY RDLP ++  PMSAAHQLQAMHAQSAELQRL
Sbjct: 917  PPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRL 976

Query: 1154 ALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190
            A+E QQWLH H  +H   LP+QEDYYS LKKE DK L
Sbjct: 977  AME-QQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL 1012



 Score =  219 bits (559), Expect = 9e-57
 Identities = 199/583 (34%), Positives = 260/583 (44%), Gaps = 103/583 (17%)

Query: 1   MKTRQNKDSMS-MRSGRKKEAPGP-------REELRSRGRASPGGVSTSSSDGKAEKSRQ 52
           M+TR+++ SMS +RSGRKK+   P        E++RS GR SP   STSS+D KAE  ++
Sbjct: 18  MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKK 77

Query: 53  TAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLD--SLDG 110
           +AKK + E +S  K NK+ R +  S++E  +  + KKTKT QE+ RP SPS+ +  S D 
Sbjct: 78  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKT-QEISRPNSPSEGEGESSDS 136

Query: 111 RSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARP---YHPPPLFPP 167
           RS+ND+GSSDP+DIDQDNRSTSPSI SP   E+DSDSS+      A+P     P  + P 
Sbjct: 137 RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPA 196

Query: 168 SPQPPDSTPRQPEASFEPH-----PSVTPTGYHAPMEP-------PTSRMFQA------- 208
               P  TP+ P     P      P  +PT   AP +P       P + + QA       
Sbjct: 197 PSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR 256

Query: 209 -----PPGAPPPHPQLYP-GGTGGVLSG-----PPMGPKG-GGAASSVGGPNGGKQHPPP 256
                PP  P PHP L P  G+ G  S      PP+  +G  G  S   GP    QHP P
Sbjct: 257 PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPL--LQHPGP 314

Query: 257 TTPISVSSSGASGAPP--TKPPTT--------PVGGGNLPSAPPPANFPHVTPNLPPPPA 306
             P  +    + G  P  T P           P     L S  PP   P     LPP P 
Sbjct: 315 PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQP-----LPPAPL 369

Query: 307 LRP-LNNASASP----PGLGAQPLPGHL--PSPHAMGQGMGGLPPGPEKGPTLAPSPHSL 359
             P +     +P    P   A   P HL  PSP +M      LPP P   P  + S H  
Sbjct: 370 AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMN---ANLPPPPALKPLSSLSTHHP 426

Query: 360 PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSL- 418
           P    SA  PP++    S    S+ A     + S +  P PAS           PPT L 
Sbjct: 427 P----SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASH----------PPTGLH 472

Query: 419 SVSNQPPKYTQPSLPSQAVWSQGPPP-PPPYGRLLANSNAHPGPF--PPSTGAQSTAHPP 475
            V+ QPP    P +P       GPPP  PP     +   A PG    PP +GA ++    
Sbjct: 473 QVAPQPPFAQHPFVPG------GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSI 526

Query: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518
                      Q +++     ++ +        PPPP   P P
Sbjct: 527 AGGSSCPLPTVQIKEEALDDAEEPE-------SPPPPPRSPSP 562


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  709 bits (1830), Expect = 0.0
 Identities = 451/937 (48%), Positives = 531/937 (56%), Gaps = 126/937 (13%)

Query: 298  TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH 357
            +P++P P      +++SA    L AQP    L +P  +       PPG  + PT  P+P 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPA--LQAPTGVTPAPSSAPPGTPQLPTPGPTP- 768

Query: 358  SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
                  S+   PP   P +S + +   A ++    +            P  PH  P P  
Sbjct: 769  ------SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHP-- 820

Query: 418  LSVSNQPPKYT------QPSLPSQA---VWSQGPPPPPPY--GRLLANSNAHPGP----- 461
               S  PP         QPS PS A   +  QGPP P     G LL     HPGP     
Sbjct: 821  ---SPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ----HPGPPQPFG 873

Query: 462  FPP--STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPL 519
             PP  S G       P + + H   Q    Q   Q QQ  ++Q      PP P A PH  
Sbjct: 874  LPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPL----PPAPLAMPH-- 927

Query: 520  EGGSSHHAHPYAMSPSLGSLRPYPPGP-AHLPPPH--SQVSYSQAGPNGPPVSSSSNSSS 576
                        + P   +  P  P P AH  PPH      +S      PP +    SS 
Sbjct: 928  ------------IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSL 975

Query: 577  STSQGSYPCSHPSPSQ-GPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPG 635
            ST     P +HP P Q  PQ  P P  P                   + P G   +    
Sbjct: 976  STHHP--PSAHPPPLQLMPQSQPLPSSP-------------------AQPPGLTQSQNLP 1014

Query: 636  PPPYGKRAPSPGAYKTATPPGYK-----PGSPPSFRTGTPPGYRGTS-PPAGPGTFKPGS 689
            PPP     P  G ++ A  P +      PG PP     TPP    TS PPAGPGT     
Sbjct: 1015 PPPASH--PPTGLHQVAPQPPFAQHPFVPGGPPPI---TPPTCPSTSTPPAGPGTS---- 1065

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSP 749
                  P   A  SG         A  S  PL   QIK+E  ++ E PESP PP RSPSP
Sbjct: 1066 ---AQPPCSGAAASG------GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSP 1116

Query: 750  PPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQ 809
             P VVD PSHASQSARF KHLDRG+NSCAR+DLYF+PL GSKLAKKR + +EK +REAEQ
Sbjct: 1117 EPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQ 1176

Query: 810  RAREEKEREREREREKEREREKERELERSVKL---AQEGRAPVECPSL-GPVPHRPPFE- 864
            +AREE+ERE+E+E+E+ERERE+ERE ER+ K    A EGR  +  P L GP   RP FE 
Sbjct: 1177 KAREEREREKEKEKEREREREREREAERAAKASSSAHEGR--LSDPQLSGPGHMRPSFEP 1234

Query: 865  PGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALY 924
            P + +A VPPY+GPDTPALRTLSEYARPHVMSP NRNHPFY+PL   DP LL Y++P LY
Sbjct: 1235 PPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDP-LLAYHMPGLY 1293

Query: 925  SSDPAARE--------REREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGG 976
            + DP  RE        RERE RER+LR+R+KPGFEVKP EL+PLH    P ++ F RH  
Sbjct: 1294 NVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANP-MEHFARHSA 1352

Query: 977  LALQPGPPGLHPF-PFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALG 1035
            L + P   G HPF  FHP L PLERERLAL AGP LRP+MSY +RLAAER HAER+A+L 
Sbjct: 1353 LTIPP-TAGPHPFASFHPGLNPLERERLAL-AGPQLRPEMSYPDRLAAERIHAERMASLT 1410

Query: 1036 NDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASAS-VHPLIDPLASGSHLTRIPY 1094
            +DPLARLQM NVTPHHHQHSHIHSHLHLHQQD +H  SA  VHPL+DPL +G HL R PY
Sbjct: 1411 SDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPY 1470

Query: 1095 PAGTLPNPLLPHPLHENEVLRHQLFAAPY-RDLPASLSAPMSAAHQLQAMHAQSAELQRL 1153
            P GTLPNPLL  P HE+E+LRH +F  PY RDLP ++  PMSAAHQLQAMHAQSAELQRL
Sbjct: 1471 PPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRL 1530

Query: 1154 ALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190
            A+E QQWLH H  +H   LP+QEDYYS LKKE DK L
Sbjct: 1531 AME-QQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL 1566



 Score =  219 bits (559), Expect = 9e-57
 Identities = 199/583 (34%), Positives = 260/583 (44%), Gaps = 103/583 (17%)

Query: 1    MKTRQNKDSMS-MRSGRKKEAPGP-------REELRSRGRASPGGVSTSSSDGKAEKSRQ 52
            M+TR+++ SMS +RSGRKK+   P        E++RS GR SP   STSS+D KAE  ++
Sbjct: 572  MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKK 631

Query: 53   TAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLD--SLDG 110
            +AKK + E +S  K NK+ R +  S++E  +  + KKTKT QE+ RP SPS+ +  S D 
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKT-QEISRPNSPSEGEGESSDS 690

Query: 111  RSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARP---YHPPPLFPP 167
            RS+ND+GSSDP+DIDQDNRSTSPSI SP   E+DSDSS+      A+P     P  + P 
Sbjct: 691  RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPA 750

Query: 168  SPQPPDSTPRQPEASFEPH-----PSVTPTGYHAPMEP-------PTSRMFQA------- 208
                P  TP+ P     P      P  +PT   AP +P       P + + QA       
Sbjct: 751  PSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR 810

Query: 209  -----PPGAPPPHPQLYP-GGTGGVLSG-----PPMGPKG-GGAASSVGGPNGGKQHPPP 256
                 PP  P PHP L P  G+ G  S      PP+  +G  G  S   GP    QHP P
Sbjct: 811  PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPL--LQHPGP 868

Query: 257  TTPISVSSSGASGAPP--TKPPTT--------PVGGGNLPSAPPPANFPHVTPNLPPPPA 306
              P  +    + G  P  T P           P     L S  PP   P     LPP P 
Sbjct: 869  PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQP-----LPPAPL 923

Query: 307  LRP-LNNASASP----PGLGAQPLPGHL--PSPHAMGQGMGGLPPGPEKGPTLAPSPHSL 359
              P +     +P    P   A   P HL  PSP +M      LPP P   P  + S H  
Sbjct: 924  AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMN---ANLPPPPALKPLSSLSTHHP 980

Query: 360  PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSL- 418
            P    SA  PP++    S    S+ A     + S +  P PAS           PPT L 
Sbjct: 981  P----SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASH----------PPTGLH 1026

Query: 419  SVSNQPPKYTQPSLPSQAVWSQGPPP-PPPYGRLLANSNAHPGPF--PPSTGAQSTAHPP 475
             V+ QPP    P +P       GPPP  PP     +   A PG    PP +GA ++    
Sbjct: 1027 QVAPQPPFAQHPFVPG------GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSI 1080

Query: 476  VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518
                       Q +++     ++ +        PPPP   P P
Sbjct: 1081 AGGSSCPLPTVQIKEEALDDAEEPE-------SPPPPPRSPSP 1116



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 15/33 (45%), Positives = 26/33 (78%), Gaps = 1/33 (3%)

Query: 807 AEQRAREEKEREREREREKERE-REKERELERS 838
           A++   ++KE++R+R+R++ERE R+K RE E S
Sbjct: 3   ADKDKDKDKEKDRDRDRDREREKRDKARESENS 35



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 9/38 (23%), Positives = 26/38 (68%)

Query: 814 EKEREREREREKEREREKERELERSVKLAQEGRAPVEC 851
           +K++++++E++++R+R++ERE     + ++  R    C
Sbjct: 4   DKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSC 41


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  709 bits (1830), Expect = 0.0
 Identities = 451/937 (48%), Positives = 531/937 (56%), Gaps = 126/937 (13%)

Query: 298  TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH 357
            +P++P P      +++SA    L AQP    L +P  +       PPG  + PT  P+P 
Sbjct: 712  SPSIPSPQDNESDSDSSAQQQMLQAQPPA--LQAPTGVTPAPSSAPPGTPQLPTPGPTP- 768

Query: 358  SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
                  S+   PP   P +S + +   A ++    +            P  PH  P P  
Sbjct: 769  ------SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHP-- 820

Query: 418  LSVSNQPPKYT------QPSLPSQA---VWSQGPPPPPPY--GRLLANSNAHPGP----- 461
               S  PP         QPS PS A   +  QGPP P     G LL     HPGP     
Sbjct: 821  ---SPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQ----HPGPPQPFG 873

Query: 462  FPP--STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPL 519
             PP  S G       P + + H   Q    Q   Q QQ  ++Q      PP P A PH  
Sbjct: 874  LPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPL----PPAPLAMPH-- 927

Query: 520  EGGSSHHAHPYAMSPSLGSLRPYPPGP-AHLPPPH--SQVSYSQAGPNGPPVSSSSNSSS 576
                        + P   +  P  P P AH  PPH      +S      PP +    SS 
Sbjct: 928  ------------IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSL 975

Query: 577  STSQGSYPCSHPSPSQ-GPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPG 635
            ST     P +HP P Q  PQ  P P  P                   + P G   +    
Sbjct: 976  STHHP--PSAHPPPLQLMPQSQPLPSSP-------------------AQPPGLTQSQNLP 1014

Query: 636  PPPYGKRAPSPGAYKTATPPGYK-----PGSPPSFRTGTPPGYRGTS-PPAGPGTFKPGS 689
            PPP     P  G ++ A  P +      PG PP     TPP    TS PPAGPGT     
Sbjct: 1015 PPPASH--PPTGLHQVAPQPPFAQHPFVPGGPPPI---TPPTCPSTSTPPAGPGTS---- 1065

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSP 749
                  P   A  SG         A  S  PL   QIK+E  ++ E PESP PP RSPSP
Sbjct: 1066 ---AQPPCSGAAASG------GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSP 1116

Query: 750  PPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQ 809
             P VVD PSHASQSARF KHLDRG+NSCAR+DLYF+PL GSKLAKKR + +EK +REAEQ
Sbjct: 1117 EPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQ 1176

Query: 810  RAREEKEREREREREKEREREKERELERSVKL---AQEGRAPVECPSL-GPVPHRPPFE- 864
            +AREE+ERE+E+E+E+ERERE+ERE ER+ K    A EGR  +  P L GP   RP FE 
Sbjct: 1177 KAREEREREKEKEKEREREREREREAERAAKASSSAHEGR--LSDPQLSGPGHMRPSFEP 1234

Query: 865  PGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALY 924
            P + +A VPPY+GPDTPALRTLSEYARPHVMSP NRNHPFY+PL   DP LL Y++P LY
Sbjct: 1235 PPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDP-LLAYHMPGLY 1293

Query: 925  SSDPAARE--------REREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGG 976
            + DP  RE        RERE RER+LR+R+KPGFEVKP EL+PLH    P ++ F RH  
Sbjct: 1294 NVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANP-MEHFARHSA 1352

Query: 977  LALQPGPPGLHPF-PFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALG 1035
            L + P   G HPF  FHP L PLERERLAL AGP LRP+MSY +RLAAER HAER+A+L 
Sbjct: 1353 LTIPP-TAGPHPFASFHPGLNPLERERLAL-AGPQLRPEMSYPDRLAAERIHAERMASLT 1410

Query: 1036 NDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASAS-VHPLIDPLASGSHLTRIPY 1094
            +DPLARLQM NVTPHHHQHSHIHSHLHLHQQD +H  SA  VHPL+DPL +G HL R PY
Sbjct: 1411 SDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPY 1470

Query: 1095 PAGTLPNPLLPHPLHENEVLRHQLFAAPY-RDLPASLSAPMSAAHQLQAMHAQSAELQRL 1153
            P GTLPNPLL  P HE+E+LRH +F  PY RDLP ++  PMSAAHQLQAMHAQSAELQRL
Sbjct: 1471 PPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRL 1530

Query: 1154 ALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL 1190
            A+E QQWLH H  +H   LP+QEDYYS LKKE DK L
Sbjct: 1531 AME-QQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL 1566



 Score =  219 bits (559), Expect = 9e-57
 Identities = 199/583 (34%), Positives = 260/583 (44%), Gaps = 103/583 (17%)

Query: 1    MKTRQNKDSMS-MRSGRKKEAPGP-------REELRSRGRASPGGVSTSSSDGKAEKSRQ 52
            M+TR+++ SMS +RSGRKK+   P        E++RS GR SP   STSS+D KAE  ++
Sbjct: 572  MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKK 631

Query: 53   TAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLD--SLDG 110
            +AKK + E +S  K NK+ R +  S++E  +  + KKTKT QE+ RP SPS+ +  S D 
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKT-QEISRPNSPSEGEGESSDS 690

Query: 111  RSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARP---YHPPPLFPP 167
            RS+ND+GSSDP+DIDQDNRSTSPSI SP   E+DSDSS+      A+P     P  + P 
Sbjct: 691  RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPA 750

Query: 168  SPQPPDSTPRQPEASFEPH-----PSVTPTGYHAPMEP-------PTSRMFQA------- 208
                P  TP+ P     P      P  +PT   AP +P       P + + QA       
Sbjct: 751  PSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR 810

Query: 209  -----PPGAPPPHPQLYP-GGTGGVLSG-----PPMGPKG-GGAASSVGGPNGGKQHPPP 256
                 PP  P PHP L P  G+ G  S      PP+  +G  G  S   GP    QHP P
Sbjct: 811  PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPL--LQHPGP 868

Query: 257  TTPISVSSSGASGAPP--TKPPTT--------PVGGGNLPSAPPPANFPHVTPNLPPPPA 306
              P  +    + G  P  T P           P     L S  PP   P     LPP P 
Sbjct: 869  PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQP-----LPPAPL 923

Query: 307  LRP-LNNASASP----PGLGAQPLPGHL--PSPHAMGQGMGGLPPGPEKGPTLAPSPHSL 359
              P +     +P    P   A   P HL  PSP +M      LPP P   P  + S H  
Sbjct: 924  AMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMN---ANLPPPPALKPLSSLSTHHP 980

Query: 360  PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSL- 418
            P    SA  PP++    S    S+ A     + S +  P PAS           PPT L 
Sbjct: 981  P----SAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASH----------PPTGLH 1026

Query: 419  SVSNQPPKYTQPSLPSQAVWSQGPPP-PPPYGRLLANSNAHPGPF--PPSTGAQSTAHPP 475
             V+ QPP    P +P       GPPP  PP     +   A PG    PP +GA ++    
Sbjct: 1027 QVAPQPPFAQHPFVPG------GPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSI 1080

Query: 476  VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518
                       Q +++     ++ +        PPPP   P P
Sbjct: 1081 AGGSSCPLPTVQIKEEALDDAEEPE-------SPPPPPRSPSP 1116



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 15/33 (45%), Positives = 26/33 (78%), Gaps = 1/33 (3%)

Query: 807 AEQRAREEKEREREREREKERE-REKERELERS 838
           A++   ++KE++R+R+R++ERE R+K RE E S
Sbjct: 3   ADKDKDKDKEKDRDRDRDREREKRDKARESENS 35



 Score = 31.2 bits (69), Expect = 6.1
 Identities = 9/38 (23%), Positives = 26/38 (68%)

Query: 814 EKEREREREREKEREREKERELERSVKLAQEGRAPVEC 851
           +K++++++E++++R+R++ERE     + ++  R    C
Sbjct: 4   DKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSC 41


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  162 bits (411), Expect = 1e-39
 Identities = 206/724 (28%), Positives = 269/724 (37%), Gaps = 130/724 (17%)

Query: 89   KTKTEQELPRPQSPSDLDSLDGRSLND---DGSSDPRDIDQDNRSTSPSIYSPGSVE--N 143
            K+     LP   +P     +DG S        +S P++   ++   S +  S G++    
Sbjct: 732  KSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLA 791

Query: 144  DSDSSSGLSQGPARPYHPPPLFPPSPQPPD---STPRQP-EASFEPHPSV-------TPT 192
            DS S  G+S  P     P       P  P    S+P  P EASF P  S+       +P 
Sbjct: 792  DSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPA 851

Query: 193  GYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQ 252
              H+P  P       +P GAP P   + P    GV   P   P    +  ++  P  G  
Sbjct: 852  TTHSPTPP-------SPKGAPTP-SAVTPLSPKGVTLPPKETPT--PSVVNLPFPKEGPA 901

Query: 253  HPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPP------- 305
             P P    ++S + +S   P K   TP   G +P++P P   P      PP P       
Sbjct: 902  TPAPKQAPALSMTSSS---PKKARATPAPKG-IPASPSPKGAPTPPAATPPSPKGGPATP 957

Query: 306  ----ALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLP- 360
                A  P      SP G  A P P   P+P A        PP P+ GP   PSP   P 
Sbjct: 958  SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPA------ATPPSPKGGPA-TPSPKGAPT 1010

Query: 361  PASSSAPAP---PMRFPYSSSSSSSAAASSSSSSSSSSASPFP------ASQALPSYPHS 411
            P + + P+P   P   P+   +S+  AA+  S   S +A+P P       +  LPS P  
Sbjct: 1011 PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS-PKG 1069

Query: 412  FPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGP-----FPPST 466
             P   SL  +  PP  T PS         GP  P P G  +  +   P P      PP  
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKG------GPATPSPKGAPMPPAATPPSPKGGLATPPHK 1123

Query: 467  GAQST--AHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSS 524
            GA +T  A PP                             G + PPP GA   P      
Sbjct: 1124 GAPTTPAATPP-------------------------SPKGGLATPPPKGAPTTPA----- 1153

Query: 525  HHAHPYAMSPSLGSLRPYPPGPAHLP---PPHSQVSYSQAGPNGPPVSSSSNSSSSTSQG 581
              A P   SP  G   P P G    P   PP  +   +   P G P + ++   S     
Sbjct: 1154 --ATP--PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG-- 1207

Query: 582  SYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGK 641
                + PSP   P   P   PP P    ++ +      T A++P   K   P  PPP G 
Sbjct: 1208 --GLATPSPKGAPT-TPAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GGPATPPPKG- 1262

Query: 642  RAPSPGAYKTATPPGYKPG--SPPSFRTGTPPGYRGTSPPAGPGTFKP-GSPTVGPGPLP 698
             AP+P A   ATPP  K G  +PP      P      SP  GP T  P G+PT  P    
Sbjct: 1263 -APTPPA---ATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPT--PPAAT 1316

Query: 699  PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPES---PVPPARSPSPPPKVVD 755
            P  P G P  PPP  AP + P ++    K  P     TP S   P  P+    P P    
Sbjct: 1317 PPSPKGSPGTPPPKGAP-TPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAA- 1374

Query: 756  VPSH 759
             PSH
Sbjct: 1375 TPSH 1378



 Score =  137 bits (346), Expect = 5e-32
 Identities = 204/792 (25%), Positives = 286/792 (36%), Gaps = 139/792 (17%)

Query: 155  PARPYHPPP-----LFPPSPQ----PPDSTPRQPEASFE-PHPSVTPTGYHA-PMEPPTS 203
            P  P   PP     L  PSP+     P +TP  P+     P P   PT   A P  P   
Sbjct: 1195 PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1254

Query: 204  RMFQAPPGAPPPHPQLYPGGTGGVLSGP-----------PMGPKGGGAASSVGGPNGGKQ 252
                 P GAP P     P   GG+ + P           P  PKGG A S    P  G  
Sbjct: 1255 PATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATS----PPKGAP 1310

Query: 253  HPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN 312
             PP  TP   S  G+ G PP K   TP      P+  PP+  P  TP LP   A  P + 
Sbjct: 1311 TPPAATP--PSPKGSPGTPPPKGAPTP------PAVTPPS--PKGTPTLP---ATTPSSK 1357

Query: 313  ASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMR 372
               + P     P P      H  G  M   PP P++GP + PSP   P + +  P  P +
Sbjct: 1358 GGPTTPSSKEGPTPPAATPSHKGGPAM--TPPSPKRGPAI-PSPKGDPTSPAVIPLSPKK 1414

Query: 373  FPYSSSSSSSAAASSSSSSSSSSASPF-----PASQAL---PSYPHSFPPPTSLSVSNQP 424
             P +  +   AA  S    +  + +P      PA+ A    P+ P S   PT  +V+  P
Sbjct: 1415 APATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVT--P 1472

Query: 425  PKYTQPSLPSQAVWS----QGPPPPPPYGR--LLANSNAHPGPFPPSTGAQSTAHPPVST 478
            P   +P  P Q   S    + P  P P G   L A   + P   P +  ++     P +T
Sbjct: 1473 PSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTAT 1532

Query: 479  HHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEG----GSSHHAHPYAMSP 534
                    ++       ++           P    A P P E      S   + P A++P
Sbjct: 1533 -----LLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTP 1587

Query: 535  SLGSLRPYP-----------------PGPAHLPPPHSQVSYSQAGPNG----PPVSSSSN 573
            S     P P                 P P  + PP  +   +   P G    PPV+ SS 
Sbjct: 1588 STYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSL 1647

Query: 574  SSSSTSQGSYPCSHPSP-SQGPQGAPYPFPP--VPTVTTSSATLSTVIATVAS--SPAGY 628
              S TS  S  C   +   Q  +G P    P  +  V  + A  ST I T  +   P   
Sbjct: 1648 KDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTK 1707

Query: 629  KTA--SPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTG-------------TPPGY 673
            K++  SPP  P    +  S G   T  P    P    S +T               PP  
Sbjct: 1708 KSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPES 1767

Query: 674  RGTSPPAGPGTFK----PGSPTVGPGPLPPAG----PSGLPSLPPP----PAAPASGPPL 721
            + ++P       K    P S +V   P PP      PS +P+LPP     P++P  G  L
Sbjct: 1768 KASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSP--GLVL 1825

Query: 722  SATQIKQEPAEEYE----TPESPVP---PARS---PSPPPKVVDVPSHASQSARFNKHLD 771
             +      PA+E E     P  P+    P +S     P PK   +P     + +     +
Sbjct: 1826 ESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNN 1885

Query: 772  RGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREK 831
            +G  + + SD     LE         D  +   ++A+  A  E + E   + ++ R  +K
Sbjct: 1886 KGSGTESDSDESVPELE-------EQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKK 1938

Query: 832  ERELERSVKLAQ 843
             R+    + L Q
Sbjct: 1939 ARKAMSKLGLRQ 1950



 Score =  136 bits (342), Expect = 1e-31
 Identities = 198/820 (24%), Positives = 273/820 (33%), Gaps = 120/820 (14%)

Query: 30   RGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKK 89
            +G  +P  V+  S  G     ++T   + V     PK      + + + + S  +++PKK
Sbjct: 862  KGAPTPSAVTPLSPKGVTLPPKETPTPS-VVNLPFPKEGPATPAPKQAPALSMTSSSPKK 920

Query: 90   TK-TEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSS 148
             + T      P SPS             G+  P      +    P+  SP        ++
Sbjct: 921  ARATPAPKGIPASPSP-----------KGAPTPPAATPPSPKGGPATPSPKWAPTPPAAT 969

Query: 149  SGLSQG-PARPYH-----PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPT 202
                +G PA P       PP   PPSP+   +TP  P+ +  P     P+   +P   P 
Sbjct: 970  PPSPKGGPATPSPKGAPTPPAATPPSPKGGPATP-SPKGAPTPPAVTPPSPKGSPAATPF 1028

Query: 203  SRMFQAPPGAPPPHPQLYPGGTGGVLSGPPM------GPKGGGAASSVGG---------- 246
             +    PP A PP P+  P  T      P         PKGG A  S+ G          
Sbjct: 1029 PKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPP 1088

Query: 247  -PNGG------KQHPPPTTPISVSSSGASGAPPTK-PPTTPVGGGNLP----SAPPPANF 294
             P GG      K  P P      S  G    PP K  PTTP      P    + PPP   
Sbjct: 1089 SPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGA 1148

Query: 295  PHVTPNLPPPP----ALRPLNNASASPPGLGAQPLPG-HLPSPHAMGQGMGGLPPGPEKG 349
            P      PP P    A  P   A  +P      P  G   PSP          PP P KG
Sbjct: 1149 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP-KG 1207

Query: 350  PTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYP 409
                PSP   P   ++ P  P     + S   +    +++  S       P  +  P+ P
Sbjct: 1208 GLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPP 1267

Query: 410  HSFPPPTSLSVSNQPPKYT-QPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGP-----FP 463
             + PP     ++  P K    P++ +      GP   PP G     +   P P      P
Sbjct: 1268 AATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTP 1327

Query: 464  PSTGA-----------QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPP 512
            P  GA           + T   P +T            ++          H G     PP
Sbjct: 1328 PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387

Query: 513  G-----AFPHPLEGGSSHHAHPY--------------AMSPSLGSLRPYPPGPAHLPPPH 553
                  A P P    +S    P               A +PS G L P    PA  P   
Sbjct: 1388 SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP----PAVTPVSL 1443

Query: 554  SQVSYSQAGPNGPPVSSSSNSSSSTS-QGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSA 612
             +   + A   GP   SS    +  +     P   P+P Q    +     P       + 
Sbjct: 1444 KKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAP 1503

Query: 613  TLSTVIAT----VASSPAGYKTASPPGPPPYGKRAPSPGAYKTAT-PPGYKPGSP----- 662
            TL  VI +    V ++P+  +    P      K+ P+  A K A  PP     SP     
Sbjct: 1504 TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPA 1563

Query: 663  ---PSFRTGTPPGYRGTSPPA-GPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASG 718
               P     TP     +SPPA  P T+K G+P+     +PPA  S  P   P P  PA  
Sbjct: 1564 IPTPKEAPATPSSKEASSPPAVTPSTYK-GAPSPKELLIPPAVTSPSPKEAPTP--PAVT 1620

Query: 719  PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPS 758
            PP         P +   TP     P   P  P  + D P+
Sbjct: 1621 PP--------SPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652



 Score =  107 bits (267), Expect = 7e-23
 Identities = 167/690 (24%), Positives = 234/690 (33%), Gaps = 136/690 (19%)

Query: 156  ARPYHPPPLFPPSPQPPDSTPRQPEASF------EPHP-------SVTPTGYHAPMEPPT 202
            A P + P     S  P    P  PEA+       EP P         +P G ++      
Sbjct: 565  AAPKNSPSFQSTSSSP--EIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIK 622

Query: 203  SRMFQAPPGAPP--------PHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGP--NGGKQ 252
            +  +  P  A P        P    +P  +       P   KG    ++   P   G   
Sbjct: 623  TDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVS 682

Query: 253  HPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANF----------PHV----- 297
              P   P+   +        T  P  P    N P AP P N           P +     
Sbjct: 683  LAPKNHPVKEGTL-------TTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVP 735

Query: 298  TPNLPP---PP------------ALRPL-----------NNASASPPGLGAQPLPGHLPS 331
            +P+LPP   PP            AL P+           + ASA+    G        PS
Sbjct: 736  SPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPS 795

Query: 332  PHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSS 391
            P  +        P  +KG   +  P + P  + S+P  P+   +   +S S   S  S +
Sbjct: 796  PLGVSVSPQTKRPPTKKG---SAGPDT-PIGNLSSPVSPVEASFLPENSLSFQGSKDSPA 851

Query: 392  SSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPP---- 447
            ++ S +P P+ +  P+ P +  P +   V+  P +   PS+ +     +GP  P P    
Sbjct: 852  TTHSPTP-PSPKGAPT-PSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAP 909

Query: 448  ------YGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQ 501
                       A +   P   P S   +    PP +T                  +    
Sbjct: 910  ALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAAT--------------PPSPKGGPA 955

Query: 502  QHHGNSGPPPPGAFPHPLEGGSSHHA-----HPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556
                   P PP A P   +GG +  +      P A +P      P  P P   P P    
Sbjct: 956  TPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTP---P 1012

Query: 557  SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP--FPPVPTVTTSSATL 614
            + +   P G P ++     +ST   + P   PSP   P   P P   P  P  T  S   
Sbjct: 1013 AVTPPSPKGSPAATPFPKGASTPPAATP---PSPKGSPAATPLPKGAPTTPAATLPSPKG 1069

Query: 615  STVIATVASSPAGYKTASPPGP-----PPYGKRAPSPGAYKTATPPGYKPG--SPPSFRT 667
                 ++  +P     A+PP P      P  K AP P A   ATPP  K G  +PP    
Sbjct: 1070 GPATPSLKGAPTP-PAATPPSPKGGPATPSPKGAPMPPA---ATPPSPKGGLATPPHKGA 1125

Query: 668  GTPPGYRGTSPPAGPGTFKP-GSPTVGPGPLPPAGPSGLPSLPP--PPAAPASGPP---- 720
             T P     SP  G  T  P G+PT  P   PP+   GL + PP   P  PA+ PP    
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTT-PAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1184

Query: 721  -LSATQIKQEPAEEYETPESPVPPARSPSP 749
             L+    K  P     TP SP     +PSP
Sbjct: 1185 GLATPSPKGAPTTPAATPPSPKGGLATPSP 1214



 Score =  100 bits (248), Expect = 1e-20
 Identities = 188/719 (26%), Positives = 243/719 (33%), Gaps = 160/719 (22%)

Query: 137  SPGSVEN-DSDSSSGLSQGPARPYHPP---------PLFPPSPQPPD----------STP 176
            S G + N +  S + L   P  P  P          P+ PP P P D            P
Sbjct: 468  SSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFP 527

Query: 177  RQPE-----ASFEPHP-SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSG 230
             Q +     AS E  P S    G     +P    + QA P   P              S 
Sbjct: 528  TQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQS--------TSSS 579

Query: 231  P--PMGPKGGGAASSVGGPNG-GKQHPPPTTPISVSSSGA-----------SGAPPTKPP 276
            P  P+ P+   A  S+G P   GK     T+P+ V+SS +           S  P  K  
Sbjct: 580  PEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSS 639

Query: 277  --TTPVGGGNLPSAPPPANFPHV-----------TPNLPPPPALRPLNNA--SASPPGLG 321
              T  V    L SA P    P             +P L    +L P N+     +   L 
Sbjct: 640  LITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLP 699

Query: 322  AQPLPGH----LPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSS 377
              P         PSP      +  L   PE  P   PSP SLPPA +    PP       
Sbjct: 700  LVPTASENCPVAPSPQNTCAPLATLVLAPEI-PKSVPSP-SLPPAGT----PPGTKKVDG 753

Query: 378  SSSSSAAASSSSS-----SSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL 432
             S +SA A  +SS     +  S AS   +S+   +Y    P P  +SVS Q  +      
Sbjct: 754  ISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKR------ 807

Query: 433  PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPP--STGAQSTAHPPVSTHHHHHQQQQQQQ 490
            P     S GP  P   G L +  +     F P  S   Q +   P +TH           
Sbjct: 808  PPTKKGSAGPDTP--IGNLSSPVSPVEASFLPENSLSFQGSKDSPATTH----------- 854

Query: 491  QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYP-PGPAHL 549
                           +  PP P   P P        +    +SP   +L P   P P+ +
Sbjct: 855  ---------------SPTPPSPKGAPTP--------SAVTPLSPKGVTLPPKETPTPSVV 891

Query: 550  PPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP---FPPVPT 606
              P  +   +   P   P  S ++SS   ++ +        S  P+GAP P    PP P 
Sbjct: 892  NLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPK 951

Query: 607  ---VTTSSATLSTVIATVASSP-AGYKTASPPGPP----------------PYGKRAPSP 646
                T S     T  A    SP  G  T SP G P                P  K AP+P
Sbjct: 952  GGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTP 1011

Query: 647  GAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGT--FKPGSPTVGPGPLP-PAGPS 703
             A    +P G    +P      TPP     SP   P       G+PT     LP P G  
Sbjct: 1012 PAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071

Query: 704  GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE---SPVPPARSPSPPPKVVDVPSH 759
              PSL   P  PA+ PP      K  PA    TP    +P+PPA +P  P   +  P H
Sbjct: 1072 ATPSLKGAPTPPAATPPSP----KGGPA----TPSPKGAPMPPAATPPSPKGGLATPPH 1122



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 170/713 (23%), Positives = 240/713 (33%), Gaps = 148/713 (20%)

Query: 92  TEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGL 151
           TEQELP+PQ+ + +  +                     S + ++  PG            
Sbjct: 12  TEQELPQPQAETAVLPMSSA-----------------LSVTAALGQPG------------ 42

Query: 152 SQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPS-VTPTGYHAPMEPPTSRMFQAPP 210
                 P  PPP  P   Q P S   Q  AS  P PS +  T    P  P +S     P 
Sbjct: 43  ------PTLPPPCSPAPQQCPLSAANQ--ASPFPSPSTIASTPLEVPF-PQSSSGTALPL 93

Query: 211 GAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISV------SS 264
           G  P  P   P      L GPP+ P     AS +  P   K  P  + P+++      S 
Sbjct: 94  GTAPEAPTFLPN-----LIGPPISPAALALASPMIAPT-LKGTPSSSAPLALVALAPHSV 147

Query: 265 SGASGAPP---TKPPTTPV---GGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPP 318
             +S  PP   T PP+  V   G     SAP   + P    N  P   + P    + SPP
Sbjct: 148 QKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVV-PNPKGTPSPP 206

Query: 319 GLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSS 378
            +    +P H  +P A  Q              +A  P + P  + +  +P ++     +
Sbjct: 207 CI-VSTVPYHCVTPMASIQS------------GVASLPQTTPTTTLAIASPQVK----DT 249

Query: 379 SSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLP--SQA 436
           + SS   S  +  S S   P               PP +LS+S Q       SLP  + +
Sbjct: 250 TISSVLISPQNPGSLSLKGP-------------VSPPAALSLSTQ-------SLPVVTSS 289

Query: 437 VWSQGPPPPPPYGRLLANSNA--HPGPFPP-----STGAQSTAHPPVSTHHHHHQQQQQQ 489
             + GP  PP +   L +  A  H   F        TG  + + P V T    H      
Sbjct: 290 QKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGAS 349

Query: 490 QQQQQQQQQQQQQHHGNSGPPPPGAFPHPL----------------EGGSSHHAHPYAMS 533
              Q+         +    P    AFP                     GS + A  +++S
Sbjct: 350 YPSQRSVIPPLPSRN-EVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLS 408

Query: 534 PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN--SSSSTSQGSYPCSHPSPS 591
           P+   +    P   +  P  +Q+  S  G     V++     ++ +T+     C  P  S
Sbjct: 409 PTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMS 468

Query: 592 QGPQGAPYPFPPVPTVTTSSATL--STVIATVASSPAGYKTASPPGPPPYG-KRAPSPGA 648
            GP     P  P   V    A    ST +AT    P      SPP P P   K  PS   
Sbjct: 469 SGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIP-----VSPPLPDPEDLKNLPSSVL 523

Query: 649 YKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
            K  T    +  + P+   G P        PA  G      PTV   PL  A P   PS 
Sbjct: 524 VKFPTQKDLQ--TVPASLEGAP------FSPAQAGLTTKKDPTV--LPLVQAAPKNSPSF 573

Query: 709 PPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHAS 761
               ++P       AT  K+   E       P+P  +  S     + V S AS
Sbjct: 574 QSTSSSPEIPLSPEATLAKKSLGE-------PLPIGKPASSMTSPLGVNSSAS 619



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 138/620 (22%), Positives = 205/620 (33%), Gaps = 106/620 (17%)

Query: 18   KEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEIS 77
            K AP P        + +P   +T+ S  K   +  ++K+     A+TP           S
Sbjct: 1330 KGAPTPPAVTPPSPKGTPTLPATTPSS-KGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS 1388

Query: 78   ESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYS 137
                    +PK   T   +  P SP    +     +  +G++ P   D      +P   +
Sbjct: 1389 PKRGPAIPSPKGDPTSPAVI-PLSPKKAPATP---VTREGAATPSKGD-----LTPPAVT 1439

Query: 138  PGSVENDSDSSSGLSQGPARPYHP-----PPLFPPSPQPPDSTPRQPEASFEPHPS-VTP 191
            P S++  + ++S    GPA P        P + PPSP+ P + P+Q   S  P  +  TP
Sbjct: 1440 PVSLKK-APATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPA-PKQVATSSSPKKAPATP 1497

Query: 192  TGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGK 251
                APM  PT       P   P  P+  P          P+ P     +         K
Sbjct: 1498 ----APMGAPTL------PAVIPSSPKEVPATPSS--RRDPIAPTATLLSKKTPATLAPK 1545

Query: 252  QHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLN 311
            +   P   ++V S   + A PT P   P    +  ++ PPA  P      P P  L    
Sbjct: 1546 EALIPPA-MTVPSPKKTPAIPT-PKEAPATPSSKEASSPPAVTPSTYKGAPSPKEL---- 1599

Query: 312  NASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGP------------TLAPSPHSL 359
                 PP +   P P   P+P A+       PP PEKGP             + PS    
Sbjct: 1600 ---LIPPAV-TSPSPKEAPTPPAV------TPPSPEKGPATPAPKGTPTSPPVTPSSLKD 1649

Query: 360  PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLS 419
             P S ++    M      +S    A    ++      +P P S  + + P    P T  S
Sbjct: 1650 SPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKS 1709

Query: 420  VSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTH 479
             +  PP    PS  +    S+GP            S   P P  P               
Sbjct: 1710 SATSPPICPDPSAKN---GSKGP-----------LSTVAPAPLLP--------------- 1740

Query: 480  HHHHQQQQQQQQQQQQQQQQQQQHHGNSGP--PPPGAFPHPLEGGSSHHAHPYAMSPSLG 537
                      Q+   +  + +   H   GP  PP      PL   +     P   S S+ 
Sbjct: 1741 ---------VQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASV- 1790

Query: 538  SLRPYPP-----GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQ 592
            S  P PP      P+ +P    +  +  + P     S S   + +      P   P P  
Sbjct: 1791 SAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPIS 1850

Query: 593  GPQGAPYPFPPVPTVTTSSA 612
            G  G P+    V   T  SA
Sbjct: 1851 G--GVPFQSVLVNMPTPKSA 1868



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 134/546 (24%), Positives = 189/546 (34%), Gaps = 76/546 (13%)

Query: 299 PNLPPP----PALRPLNNASA-----SPPGLGAQPLPGHLP-SPHAMGQGMGGLPPGPEK 348
           P LPPP    P   PL+ A+      SP  + + PL    P S       +G  P  P  
Sbjct: 43  PTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTF 102

Query: 349 GPTLAPSPHSLPPASSSAP--APPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALP 406
            P L   P S    + ++P  AP ++   SSS+  +  A +  S   SSA P     + P
Sbjct: 103 LPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPP 162

Query: 407 SYPHSFPPPT---SLSVSNQPPKYTQPSLPSQAVWS-QGPPPPPPYGRLLANSNAHPGPF 462
           S   +        S  ++   PK     +PS+ V + +G P PP     +      P   
Sbjct: 163 SVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMAS 222

Query: 463 PPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGP-PPPGAFPHPLEG 521
             S  A      P +T      Q +           Q        GP  PP A     + 
Sbjct: 223 IQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQS 282

Query: 522 GSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYS-----QAGPNG---PPVSSSSN 573
                +      P+     P   G +HL P H     S     Q GP+    P V + S 
Sbjct: 283 LPVVTSSQKTAGPNTPPDFPISLG-SHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISV 341

Query: 574 SSSSTSQGSYPCSH----PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAG-- 627
             SST   SYP       P PS+  +  P      P V  S     + I+++  SP+G  
Sbjct: 342 DHSSTG-ASYPSQRSVIPPLPSRN-EVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSL 399

Query: 628 -YKTASPPGPPPYGKRAPSPGAYK----TATPPGYKPGSPPSFRTGTPPGYRGTSPPAGP 682
              T+    P        SP A       A  P    G+ P   T        T   A  
Sbjct: 400 NVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPC-----TIAAAPT 454

Query: 683 GTFKPG---SPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPES 739
            TF+     SP +  GP+    P+   +L   P AP           K+   +   T   
Sbjct: 455 TTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAP-----------KEPSTQVATTLRI 503

Query: 740 PVPPARSPSPPPK-VVDVPSHASQSARFNKHLDRGFNSCARSDLYFVP--LEGSKLAKKR 796
           PV P   P P P+ + ++PS  S   +F            + DL  VP  LEG+  +  +
Sbjct: 504 PVSP---PLPDPEDLKNLPS--SVLVKFP----------TQKDLQTVPASLEGAPFSPAQ 548

Query: 797 ADLVEK 802
           A L  K
Sbjct: 549 AGLTTK 554



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 77/360 (21%), Positives = 126/360 (35%), Gaps = 73/360 (20%)

Query: 86   APKKTK---TEQELPRPQSPSDLDSLDGRSLND-DGSSDPRDIDQDNRSTSPS---IYSP 138
            +PKKT    T +E P   S  +  S    + +   G+  P+++      TSPS     +P
Sbjct: 1557 SPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTP 1616

Query: 139  GSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQ---------PEAS------- 182
             +V   S      +  P      PP+ P S +   ++P           P+AS       
Sbjct: 1617 PAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKK 1676

Query: 183  ---------FEPHPSVTPTGYHAPMEPPTSRMFQA--PPGAPPPHPQLYPGGTGGVLSGP 231
                       P P  TP       + P ++   A  PP  P P  +    G    ++  
Sbjct: 1677 GPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPA 1736

Query: 232  PMGP---------KGGGAASSVGGPNGGKQHPPPTTPISVSS---------SGASGAPPT 273
            P+ P         KG  A+ S  GP    +    +TP++ ++         S +  A P+
Sbjct: 1737 PLLPVQKDSSKTAKGKDASHSPKGPLAPPESKA-STPLTAAAFEKVLPKPESASVSAAPS 1795

Query: 274  KPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASP--PGLGAQPLPGHLPS 331
             P + P+    +P+ PP   F   +P L      +PL  A      P +  +P+ G +P 
Sbjct: 1796 PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPF 1855

Query: 332  PHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSS 391
               +                  P+P S   A    P P  + P + ++  S   S S  S
Sbjct: 1856 QSVL---------------VNMPTPKS---AGIPVPTPSAKQPVTKNNKGSGTESDSDES 1897


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  155 bits (391), Expect = 3e-37
 Identities = 186/718 (25%), Positives = 258/718 (35%), Gaps = 86/718 (11%)

Query: 77  SESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIY 136
           + S +  +  P   + E+  P   +     S  GR+    G++ P  + Q     S    
Sbjct: 85  TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA---SGTTRPGPLGQKGLRISAEET 141

Query: 137 SPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFE-----PHPSVTP 191
                  ++   S LS G  R    P    PSP       R   A  E     P PS  P
Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTPGTPSPA---MARRSRAAGTEVGLPRPAPSARP 198

Query: 192 TGYHAPMEPPTSRMFQAPPGA---PPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPN 248
                P E P   +  A   +   P P  +  P   GG+               S    +
Sbjct: 199 ---RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 255

Query: 249 GGKQHPPPTTPISVSSSGASGAPPTKPP-TTPVGGGNLPSAPPPANFPHVTPNLPPPPAL 307
           G      P  P   S     G    +PP  TP      P+  P ++ P  TP+ P     
Sbjct: 256 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS-PSGTKA 314

Query: 308 RPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLA--PSPHSLPPASS- 364
           RP+      PP   A PLP  LP    +   +   PP P   P+L   PSP + PP+ + 
Sbjct: 315 RPV-----PPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAP 369

Query: 365 -SAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPT---SLSV 420
            S   PPM+ P S  +        S +S S  A P P + +      S   PT   + S 
Sbjct: 370 PSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSF 429

Query: 421 SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHP-----GPFPPSTGAQSTAHP- 474
               P+ TQ SL S +  +  PP  PP    L+   + P      P      +  T HP 
Sbjct: 430 LTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL 489

Query: 475 -PVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP-----------PGAFPHPLEGG 522
             +S+   H  Q           + Q      +   PP           P   P PL+  
Sbjct: 490 QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTA 549

Query: 523 SSHHAHPYAMSPSLGSLRPY--PPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQ 580
           S+    P+  +P   +  P   PP P   PPP +  S +   P  PP  +S       S 
Sbjct: 550 SAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSP 609

Query: 581 GSYPCSHPSPSQGPQGA--PYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPP 638
              P + P P   P  A  P   PP P  +   + L+T      ++ A +   +P  PPP
Sbjct: 610 PLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669

Query: 639 YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS---PTVGPG 695
                         +PP   P SPP+    +PP     SP A P +  P S   P +   
Sbjct: 670 --------------SPPVQAPFSPPA----SPP----VSPSATPPSQAPPSLAAPPLQVP 707

Query: 696 PLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKV 753
           P PPA P   PS  PPP AP   PPL+A  ++  P+     P SP     S +PPP+V
Sbjct: 708 PSPPASPPMSPSATPPPQAP---PPLAAPPLQVPPSPPASPPMSP-----SATPPPRV 757



 Score =  139 bits (351), Expect = 1e-32
 Identities = 219/840 (26%), Positives = 289/840 (34%), Gaps = 146/840 (17%)

Query: 16  RKKEAPGPREELRSRG--RASPGGVSTSSSDGKAEKSRQTAKKA---RVEEASTPKVNKQ 70
           R K    P+    S G  R + G    + S   A +SR    +    R   ++ P+   +
Sbjct: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203

Query: 71  GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130
           G  + +S +    T  P          RP +   L     RSL+               S
Sbjct: 204 GPRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLS---------------S 244

Query: 131 TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP-----LFPPSPQPP--DSTPRQPEASF 183
           ++  + SP        S+ G  + PA P  P P     L PP   PP  D+ P     S 
Sbjct: 245 SATPLSSPA---RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 184 EPHPSVTPTGYHA-PMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAAS 242
            P  + +P+G  A P+ PP +     P   PP  P   P          P+ P    A  
Sbjct: 302 SPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATP---------LPLAPPSPSAPP 352

Query: 243 SVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPH--VTPN 300
           S+          PP TP S +    +  P   PP+            PP   PH   +P+
Sbjct: 353 SLQ-----TLPSPPATPPSQAPPSMTTPPMQAPPSL--------QTIPPIQVPHSLTSPS 399

Query: 301 LPPPPALRPLNNASASPPGLGAQPLPG--------------HLPSPHAMGQGMGGLPP-- 344
           L  PP+   L++  A+   LG+  L                 L SP          PP  
Sbjct: 400 LQAPPSPLALSSLQATT-SLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQ 458

Query: 345 GPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQA 404
            P   P   P   SL PA S   +P    P  + SS   A+ S  +  SS   P   +Q+
Sbjct: 459 APLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSS--LASHSPQAPLSSLIMPPLETQS 516

Query: 405 LPSYPHSFPPPTSLSV-------SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457
             + P    PP SL+        S  PP     S P      + PP P P         A
Sbjct: 517 SLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP-----CPLQA 571

Query: 458 HPGPF--PPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAF 515
            P P   PP     S A PP          Q          Q            PPP A 
Sbjct: 572 PPSPLTTPPPETPSSIATPP---------PQAPPALASPPLQGLPSPPLSPLATPPPQAP 622

Query: 516 PH----PLEGGSSHHAHPYAMSPSLGSLRPYPPGP--AHL------PPPHSQVSYSQAGP 563
           P     PL+   S  A P  +SP L +  P  P     HL      PPP   V    + P
Sbjct: 623 PXLALPPLQAPPSPPASP-PLSP-LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 680

Query: 564 NGPPVSSSSNSSSST-------------SQGSYPCSHPSPSQGPQGAPY---------PF 601
             PPVS S+   S               S  + P   PS +  PQ  P          P 
Sbjct: 681 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPS 740

Query: 602 PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA-PSPGAYKT-ATPPGYKP 659
           PP     + SAT    +  + ++P      SPP   P    A P P A    ATPP    
Sbjct: 741 PPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQAL 800

Query: 660 GSPPSFRTGTPPGYRGTSPPAGP-GTFKPGSPTVGPGPL--PPAGPSGLPSLPPPPAAPA 716
            SPP+   G  P     S P  P  T  P +P V   PL   P  P   P+L  P   P 
Sbjct: 801 PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860

Query: 717 SGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776
            GP  S +  +   A     P  P PP+RSPS      D+  H+S +    + L RG++S
Sbjct: 861 PGPDTSVSGPRLTLA---LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 916



 Score =  122 bits (305), Expect = 3e-27
 Identities = 170/639 (26%), Positives = 227/639 (35%), Gaps = 126/639 (19%)

Query: 73   SEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTS 132
            S  +S   S  T  P +  +      PQ+P  L SL    L    S  P  +     S +
Sbjct: 474  SPAVSPLSSPLTIHPLQALSSLASHSPQAP--LSSLIMPPLETQSSLAPPSLQTPPASLT 531

Query: 133  -------PSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSP--QPPDSTPRQPEASF 183
                   PS+  P      +  ++   + P  P   P   PPSP   PP   P  P +  
Sbjct: 532  TPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPP---PETPSSIA 588

Query: 184  EPHPSVTPTGYHAPME----PPTSRMFQAPPGAPP----PHPQLYPGGTGGVLSGPPMGP 235
             P P   P     P++    PP S +   PP APP    P  Q  P       + PP+ P
Sbjct: 589  TPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP----ASPPLSP 644

Query: 236  KGGGAASSVGGPNGGKQH-------PPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSA 288
                A  S   PN    H       PPP+ P+    S     PP  PP +P       SA
Sbjct: 645  L---ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS-----PPASPPVSP-------SA 689

Query: 289  PPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEK 348
             PP+  P   P+L  PP   P +  ++ P    A P P    +P  +      +PP P  
Sbjct: 690  TPPSQAP---PSLAAPPLQVPPSPPASPPMSPSATPPP---QAPPPLAAPPLQVPPSPPA 743

Query: 349  GPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSY 408
             P ++PS    P       APP++ P S  +S   +  +     +  A   P  QALPS 
Sbjct: 744  SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803

Query: 409  PHSFP------PPTSLSVS--NQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPG 460
            P SFP      P  SL +S    PP    P L +  +  Q PP PP    L A       
Sbjct: 804  PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL--QVPPSPPASPTLQAPRR---- 857

Query: 461  PFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLE 520
              PP+ G  ++   P  T                              PPPP   P    
Sbjct: 858  --PPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSRSPSSTL 892

Query: 521  GGSSHHAHPYAMSPSLGSLRPYPPGP----AHLPPPHSQVSYSQAGPNGPPVSSSSNSSS 576
             G     H  + + +   LR Y  GP    A  PPP +++              ++   +
Sbjct: 893  SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL--------------AACHPA 938

Query: 577  STSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA-SSPAGYKTASPPG 635
            + S+G  P   P   +G  GAP P+PP  T   S+  L T+  T    S      A  PG
Sbjct: 939  AWSRGPAP---PLAFRGAPGAPLPWPPA-TGPGSADGLCTIYETEGPESATPAPGALDPG 994

Query: 636  PPP---YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671
            P P    GK A   GA       G    SP   R G  P
Sbjct: 995  PSPGTSGGKAAAGAGA-------GASSRSPKQARLGELP 1026



 Score =  117 bits (294), Expect = 5e-26
 Identities = 169/672 (25%), Positives = 224/672 (33%), Gaps = 87/672 (12%)

Query: 92   TEQELPRPQSPSDLDSLDGRSLNDDGSSDPRD--IDQDNRSTSPSIYSPGSVENDSDSSS 149
            T   L  P SP  L SL   +     +       +    R T  S+ SP    +    S 
Sbjct: 396  TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSP 455

Query: 150  GLSQGPARPYHPP------PLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTS 203
             L    + P  PP      P   P   P    P Q  +S   H    P      M P  +
Sbjct: 456  PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLS-SLIMPPLET 514

Query: 204  RMFQAPPG--APPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPIS 261
            +   APP    PP      P      L+ PP+      A++ +  P+   + PP   P  
Sbjct: 515  QSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQT----ASAPLTTPH--LETPPCPAPCP 568

Query: 262  VSSSGASGAPP----TKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASP 317
            +       APP    T PP TP      P   PPA        LP PP          +P
Sbjct: 569  LQ------APPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAP 622

Query: 318  PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSP--------HSLPPASSSAPAP 369
            P L   PL    PSP          P  P   P   PSP        H L    S  P+P
Sbjct: 623  PXLALPPLQAP-PSP----------PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 671

Query: 370  PMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHS-------FPPPTSLSVSN 422
            P++ P+S  +S   + S++  S +  +   P  Q  PS P S        PPP +     
Sbjct: 672  PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 731

Query: 423  QPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQST-AHPPVSTHHH 481
             PP    PS P+    S    PPP    LLA       P PP++   S  A PP      
Sbjct: 732  APPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP------ 785

Query: 482  HHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPH--PLEGGSSHHAHPYAMSPSLGSL 539
                         Q           + P PP +FP   P    +S    P A  P     
Sbjct: 786  ------------PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP- 832

Query: 540  RPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSST--SQGSYPCSHPSPSQGPQGA 597
             P    P    PP    S +   P  PP      S S    +    P   P PS+ P   
Sbjct: 833  -PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 891

Query: 598  PYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGY 657
                P +   ++S+ +    +    S P G   ASPP         P+  +   A P  +
Sbjct: 892  -LSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 950

Query: 658  K--PGSP----PSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711
            +  PG+P    P+   G+  G        GP +  P    + PGP P  G SG  +    
Sbjct: 951  RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP--GTSGGKAAAGA 1008

Query: 712  PAAPASGPPLSA 723
             A  +S  P  A
Sbjct: 1009 GAGASSRSPKQA 1020



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 179/686 (26%), Positives = 237/686 (34%), Gaps = 177/686 (25%)

Query: 209 PPGAPPPHPQLYPG-----GTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVS 263
           PPG+P P P + P      G  G +   P+  + GG    +GG          T P S  
Sbjct: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG----IGG---------ATIPESAP 75

Query: 264 SSG---ASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPG- 319
            +G   ++G     P + P   G    APP         N  P P   P   +  + PG 
Sbjct: 76  RAGPTRSAGTSSRNPASRPPASGRGERAPP-------AKNTSPGPVSSPGRASGTTRPGP 128

Query: 320 LGAQPL------------PGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH---------- 357
           LG + L                P   A+  G      GP  G    PSP           
Sbjct: 129 LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMARRSRAAGT 185

Query: 358 --SLP-PASSSAPAPPMRFPYSSSSSSSAAASS-------------------SSSSSSSS 395
              LP PA S+ P PP   P  S SS+S  +++                   +S S SSS
Sbjct: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245

Query: 396 ASPF-------PASQALPSYP--HSFPPPTSLSVSNQPPKYTQP---------------- 430
           A+P        P+++  P  P   S P P  L  + +PP+ T P                
Sbjct: 246 ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ-ALRPPQVTPPRKDAAPALGPLSSSPL 304

Query: 431 SLPSQAVWSQGPPPPPPYGRLLANSNAHPGP--------FPPSTGA----QSTAHPPVST 478
           + PS +     P PPP        +   P P         PPS  A    Q+   PP + 
Sbjct: 305 ATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATP 364

Query: 479 HHHHHQQQQQQQQQQQQQQQQ----QQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSP 534
                        Q     Q     Q  H   S  P   A P PL   SS  A     SP
Sbjct: 365 PSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTS--PSLQAPPSPL-ALSSLQATTSLGSP 421

Query: 535 SLGSLRPY--------------PPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQ 580
           +L +   +              P  PA  PP    +    + P  PP+ +S   S + S 
Sbjct: 422 TLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTS--LSPAVSP 479

Query: 581 GSYPCS-HP------SPSQGPQG--APYPFPPV--------PTVTTSSATLST--VIATV 621
            S P + HP        S  PQ   +    PP+        P++ T  A+L+T  +    
Sbjct: 480 LSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLP 539

Query: 622 ASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAG 681
           + +P   +TAS P   P+ +  P P       PP      PP     TP       P A 
Sbjct: 540 SLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPE----TPSSIATPPPQAP 595

Query: 682 PGTFKP---GSPTVGPGPL---PPAGPS--GLPSLPPPPAAPASGPPLS--ATQIKQEP- 730
           P    P   G P+    PL   PP  P    LP L  PP+ PAS PPLS  AT   Q P 
Sbjct: 596 PALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPAS-PPLSPLATPSPQAPN 654

Query: 731 ---AEEYETPES--PVPPARSPSPPP 751
                  + P S  P PP ++P  PP
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPP 680



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 144/573 (25%), Positives = 199/573 (34%), Gaps = 75/573 (13%)

Query: 247 PNGGKQHPPPTTPISVSSSGASGAPPTKP---PTTPVGGGNLPSAPPPANFPHVTPNLPP 303
           P G  + PPP TP ++   GA+GA   KP       +GG  +P + P A           
Sbjct: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 304 PPALRPLNNASASPPGLGAQPLPGHLPSP-HAMGQGMGGLPPGP--EKG------PTLAP 354
            PA RP     AS  G  A P     P P  + G+  G   PGP  +KG       T+A 
Sbjct: 89  NPASRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144

Query: 355 SPHSLPPASSSAPAPPMRFPY--SSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSF 412
              +  P  S+  A   R     +  + S A A  S ++ +    P PA  A P  P   
Sbjct: 145 GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204

Query: 413 PPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTA 472
           P  +  S S      T+PS  ++   S G     P  R L +S+A P   P  +G  +  
Sbjct: 205 PRKSVSSASEH--STTEPSPAARRRPSAGGGLQRPASRSL-SSSATPLSSPARSGPSARG 261

Query: 473 HPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHP--- 529
            P    H    + +  Q  +  Q    ++      GP        P   G+     P   
Sbjct: 262 TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPD 321

Query: 530 YAMSPSLGSLRPYPP--GPAHLPPPHSQVSYS----QAGPNGPPVSSSSNSSSSTSQGSY 583
            A +P   +L P PP   P  L PP      S     + P  PP  +  + ++   Q   
Sbjct: 322 NAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPP 381

Query: 584 PCSHPSPSQGPQGAPYP---FPPVP--------TVTTSSATLSTVIATVASSP------- 625
                 P Q P     P    PP P        T +  S TL    + +  SP       
Sbjct: 382 SLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASL 441

Query: 626 --AGYKTASPPGPPPYGK--RAPSPGAYKTATPPGYKPGSPP-------------SFRTG 668
                  ++PP  PP       P+    +T+  P   P S P             S    
Sbjct: 442 TSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQ 501

Query: 669 TPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQ 728
            P       P     +  P S    P  L       LPSL PPP   AS  PL+   ++ 
Sbjct: 502 APLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASA-PLTTPHLET 560

Query: 729 EPAE---EYETPESPV--PPARSPS----PPPK 752
            P       + P SP+  PP  +PS    PPP+
Sbjct: 561 PPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQ 593



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 61/223 (27%), Positives = 77/223 (34%), Gaps = 20/223 (8%)

Query: 529 PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNG-----PPVSSSSNSSSSTSQGSY 583
           P A +P L  L P PPG    PPP +  +    G  G     P    +     +T   S 
Sbjct: 17  PAARAPGL--LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 584 PCSHPSPSQGPQGA-PYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKR 642
           P + P+ S G     P   PP       +           SSP      + PG  P G++
Sbjct: 75  PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG--PLGQK 132

Query: 643 APSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGP 702
                A +T      K    P     +    R TS P  PGT    SP +          
Sbjct: 133 GLRISAEETVARG--KATEAPKRSALSAGARRDTSGPT-PGT---PSPAMARRSRAAGTE 186

Query: 703 SGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPAR 745
            GLP  P P A P   PP    +     A E+ T E P P AR
Sbjct: 187 VGLPR-PAPSARPR--PPTEGPRKSVSSASEHSTTE-PSPAAR 225


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score =  129 bits (324), Expect = 2e-29
 Identities = 208/822 (25%), Positives = 286/822 (34%), Gaps = 153/822 (18%)

Query: 137  SPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHA 196
            SPG       +S      P  P  PPPL PP P PP   P  P  +  P   +T  G  +
Sbjct: 224  SPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWS 283

Query: 197  PMEPPT---SRMFQAPPGAPP-----PHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPN 248
             +        R   APP         PHP  YP       +  P G +   AA    GP 
Sbjct: 284  TLHGDAWGPERKGSAPPERQEQRHSLPHPYPYP---APAYTAHPPGHRLVPAAPPGPGPR 340

Query: 249  GGKQHPPPTTPISVSSSGASGAPPTKPP-----TTPVGGGNLPSAPPPANFPHVTPNLPP 303
                      P    S G    P T+PP      + V    + S+  PA      P  P 
Sbjct: 341  ----------PPGAESHGC--LPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPS 388

Query: 304  -PPAL----RPLNNASASPPGL-GAQPLPG-----HLPSPHAMGQGMGGLPPG--PEKGP 350
             PP L       +++S+S  GL G +P PG     H  +P       G L P     + P
Sbjct: 389  RPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKP 448

Query: 351  TL---APSPH-SLPPASSSAPAPP----MRFPYSSSSSSSAAASSSSSSSSSSASPF--- 399
             L   A +PH SLPP  SS P PP    +R P   +     A  ++          F   
Sbjct: 449  FLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGT 508

Query: 400  --PASQALPSYPHS----FPPPTSLSVSNQ-------PPKYTQPSLPSQAVWSQGPP--- 443
              P   A P  PH      PP +  SV  Q       PP  T  S  S +      P   
Sbjct: 509  EGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGP 568

Query: 444  ---PPPPYGRLLANSNAHPGPFPPSTGAQ---------STAHPPVSTHHHHHQQQQQQQQ 491
               PPPPY   LA S   P P PPS             + A PP      H       ++
Sbjct: 569  VSFPPPPY---LARS-IDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRR 624

Query: 492  QQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP 551
             +  + +         GP PP   P PL         P  + P +G L    P     PP
Sbjct: 625  PESPRPRVSFPKTPEVGPGPP---PGPLSKA------PQPVPPGVGELPARGPRLFDFPP 675

Query: 552  PHSQVSYSQAG-----PNG-----PPVSSSSNSSSSTSQGSYPCSHPSPSQGPQG---AP 598
               +  + +       P+G       +  S        Q     +   P + P     +P
Sbjct: 676  TPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSP 735

Query: 599  YPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPP----GPPPYGKRAPSPGAYKTATP 654
            +P    PT T  +  ++T   T  ++ A  +    P     PPP   + P P   +   P
Sbjct: 736  FPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPP 795

Query: 655  PGYKPG----SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLP-----PAGPSGL 705
            P   P     S  S   G    YRGT            + +  PGPLP     P  PSG 
Sbjct: 796  PPPSPASLLKSLASVLEGQKYCYRGTG----------AAVSTRPGPLPTTQYSPGPPSGA 845

Query: 706  PSLPPPPAAPAS--GPPLSATQIKQEP------AEEYETPESPVPPARSPSPPPKVVDVP 757
             +LPP  AAP++   P  SA+   Q        A E    E PVP   +P+ PP  + +P
Sbjct: 846  TALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLP 905

Query: 758  SHASQS---ARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREE 814
               S+S      ++  +       RS     P +    A+      E++   A+  A+EE
Sbjct: 906  PARSESEVLEEISRACETLVERVGRSAT--DPADPVDTAEPADSGTERLLPPAQ--AKEE 961

Query: 815  KE---------REREREREKEREREKERELERSVKLAQEGRA 847
                       + R++E +KE  R +    +   +  +EGRA
Sbjct: 962  AGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRA 1003



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 171/704 (24%), Positives = 228/704 (32%), Gaps = 140/704 (19%)

Query: 132 SPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTP 191
           +P   +P  +    +S  G  Q   R    P L+    Q  +S     EA+   H ++  
Sbjct: 77  APGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRY 136

Query: 192 TGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGP-------------KGG 238
            G  A + P   R+ QA         QL+   TG       + P             K  
Sbjct: 137 GGSFAELGPRIGRLQQA---------QLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRN 187

Query: 239 GAASSVGGPNGGKQHPPPTTPISVSS-SGASGAPPTKPPTTPVGGGNLPSAPPPANFPHV 297
             A   G P      PP   P+  ++ SG SG     P      G N      P   P  
Sbjct: 188 YGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLP 247

Query: 298 TPNL-----PPPPALRPLNNASASP------PGL--------------GAQP-------- 324
            P L     PPPP   PL   + SP      PGL              G+ P        
Sbjct: 248 PPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRH 307

Query: 325 -LPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSA 383
            LP   P P          PPG    P   P P   PP + S    P   P  S    S 
Sbjct: 308 SLPHPYPYP---APAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESR 364

Query: 384 AASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPK------YTQPSLPSQAV 437
              S   SS S A+        PS P   P  T+ S S+             P +P    
Sbjct: 365 VQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADH 424

Query: 438 WSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQ 497
           +         +GRL  ++++   PF    GA      P +T H                +
Sbjct: 425 YQTPALEVSHHGRLGPSAHSSRKPF---LGA------PAATPHLSLPPGPSSPPPPPCPR 475

Query: 498 QQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH------PYAMSPSLGSLRPYPPGPAH--- 548
             +        PPPP A+   L+G +   A             + G  RP PP   H   
Sbjct: 476 LLR--------PPPPPAW---LKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREG 524

Query: 549 -LPPPHSQVSYSQAGPNGPPV-------SSSSNSSSSTSQGSYPCSHPSPSQGPQGA-PY 599
            L PP S+ S      + PP        SS+SNS S +S  + P S P P    +   P 
Sbjct: 525 FLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPL 584

Query: 600 PFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKP 659
           P PP P        L  V  T+A  PA          PP      + G+++    P  + 
Sbjct: 585 PRPPSPAQNPQDPPL--VPLTLALPPA----------PPSSCHQNTSGSFRRPESPRPRV 632

Query: 660 GSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGP 719
             P +   G  PG     PP GP +  P     G G LP  GP  L   PP P       
Sbjct: 633 SFPKTPEVG--PG-----PPPGPLSKAPQPVPPGVGELPARGPR-LFDFPPTPLEDQFEE 684

Query: 720 P----------------LSATQIKQEPAEEYETPESPVPPARSP 747
           P                L  +  K+E  +++E   +P PP + P
Sbjct: 685 PAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEP 728



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 91/377 (24%), Positives = 132/377 (35%), Gaps = 78/377 (20%)

Query: 131 TSPSIYSPGSVENDSDSSSGLSQGPARP--YHPPPLFPPSPQPPDSTPRQPEASFEPH-P 187
           T P+  +P +  ++S+S S  S  PA P  + PPP    S  P    PR P  +  P  P
Sbjct: 542 TPPTPPTPTTSSSNSNSGSH-SSSPAGPVSFPPPPYLARSIDP---LPRPPSPAQNPQDP 597

Query: 188 SVTPTGYHAPMEPP------TSRMFQAPPG-----APPPHPQLYPGGTGGVLSGPPMGPK 236
            + P     P  PP      TS  F+ P       + P  P++ PG   G LS  P    
Sbjct: 598 PLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVP 657

Query: 237 GGGAASSVGGPNGGKQHPPPTTPI----------------------------------SV 262
            G       GP   +    P TP+                                    
Sbjct: 658 PGVGELPARGP---RLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQ 714

Query: 263 SSSGASGAPPTKPP----TTPVGGGNLPSAPPPANFPHVTPNL------------PPPPA 306
             +G +  PP K P     +P      P+   PA     T                PPPA
Sbjct: 715 HEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPA 774

Query: 307 LRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPE---KGPTLAPSPHSLP-PA 362
           L P    +  PP    QP P   PSP ++ + +  +  G +   +G   A S    P P 
Sbjct: 775 LPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPT 834

Query: 363 SSSAPAPP---MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLS 419
           +  +P PP      P +S++ S+  +   S+SSSS  S      A        P P  ++
Sbjct: 835 TQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMT 894

Query: 420 VSNQPPKYTQPSLPSQA 436
            +  PP  + P   S++
Sbjct: 895 PTQPPPPLSLPPARSES 911



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 155/706 (21%), Positives = 220/706 (31%), Gaps = 213/706 (30%)

Query: 299 PNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAP---- 354
           P+ PP  A  P    SAS   +G  PLP  LP  H    G    P      PT  P    
Sbjct: 33  PHPPPRSAWLPGGRCSAS---IGQPPLPAPLPPSHGSSSGHPSKPYYAPGAPTPRPLHGK 89

Query: 355 --SPHSLPPASSSAPAPPMRFP-----YSSSSSSSAAA---------------------- 385
             S H    A    PA P  +      Y S   S  A                       
Sbjct: 90  LESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPRIGR 149

Query: 386 -------SSSSSSSSSSASPFPASQALPSYPH----------SFPPPTSLSVSNQPPKYT 428
                  +  + S    A   P  + + +  H             PP   +     P   
Sbjct: 150 LQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRAAE---PPVV 206

Query: 429 QPSLPSQAVWSQGPPPPPPYGRLLANSNAH-----------PGPFPPSTGAQSTAHPPV- 476
           QP  P+      G     P G+     N+            P P PP         PP+ 
Sbjct: 207 QPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLP 266

Query: 477 ----------------STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLE 520
                           ST H      +++     ++Q+Q+     +S P P   +P+P  
Sbjct: 267 GLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQR-----HSLPHP---YPYPAP 318

Query: 521 GGSSH---HAHPYAMSPSLGSLRPYPPG-------PAHLPP------------------- 551
             ++H   H    A  P  G   P PPG       PA  PP                   
Sbjct: 319 AYTAHPPGHRLVPAAPPGPG---PRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVS 375

Query: 552 ---PHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTV- 607
                + V Y+ + P G P +++S+SSSS+S        P+P  G  GA +   P   V 
Sbjct: 376 PAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNP--GIPGADHYQTPALEVS 433

Query: 608 ----------TTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAY-------- 649
                     ++    L    AT   S     ++ PP P P   R P P A+        
Sbjct: 434 HHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRA 493

Query: 650 -------------------KTATPP---------------------GYKPGSPPSFRTGT 669
                              + A PP                      + P +PP+  T +
Sbjct: 494 AREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSS 553

Query: 670 PPGYRG--TSPPAGPGTFKPG---SPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSAT 724
                G  +S PAGP +F P    + ++ P P PP+ P+  P  PP      + PP   +
Sbjct: 554 SNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPS-PAQNPQDPPLVPLTLALPPAPPS 612

Query: 725 QIKQEPAEEYETPESPVP-------PARSPSPPPKVVD------VPSHASQSARFNKHLD 771
              Q  +  +  PESP P       P   P PPP  +        P      AR  +  D
Sbjct: 613 SCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFD 672

Query: 772 RGFNSCARSDLYFVPLEGSKLAKKRADLV----EKVRREAEQRARE 813
             F      D +  P E   L    A+++    E +R+E EQ+  E
Sbjct: 673 --FPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHE 716



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 47/195 (24%), Positives = 65/195 (33%), Gaps = 15/195 (7%)

Query: 97  PRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPA 156
           P+P       SL      D   +          +T+ +  +  + E +      L   P 
Sbjct: 721 PQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPP 780

Query: 157 RPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPH 216
               PPP  P  P PP   P  P +  +   SV     +      T       PG P P 
Sbjct: 781 LAKFPPPSQPQPPPPP---PPSPASLLKSLASVLEGQKYC--YRGTGAAVSTRPG-PLPT 834

Query: 217 PQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP 276
            Q  PG   G  + PP       A S+ G P      P  ++    S+SG   A   +  
Sbjct: 835 TQYSPGPPSGATALPPT----SAAPSAQGSP-----QPSASSSSQFSTSGGPWARERRAG 885

Query: 277 TTPVGGGNLPSAPPP 291
             PV G   P+ PPP
Sbjct: 886 EEPVPGPMTPTQPPP 900



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 84/382 (21%), Positives = 106/382 (27%), Gaps = 110/382 (28%)

Query: 432 LPSQAVWSQGPPPPPPYGRLLANSNAH--------PGPFPPSTGAQSTAH-------PPV 476
           L     WS  PP PPP    L              P P PPS G+ S+ H       P  
Sbjct: 22  LSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHGS-SSGHPSKPYYAPGA 80

Query: 477 STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSL 536
            T    H + +      Q   ++         P  PG +    +   S H    A     
Sbjct: 81  PTPRPLHGKLESLHGCVQALLRE---------PAQPGLWEQLGQLYESEHDSEEATRCYH 131

Query: 537 GSLRPYPPGPAHLPPPHSQVSYSQA-----------GPNGPPVSSSSNSSSSTSQGSYPC 585
            +LR Y    A L P   ++  +Q                PP+    N      + +Y  
Sbjct: 132 SALR-YGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGA 190

Query: 586 SHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPS 645
               P       P    PVP    S                           P G+   S
Sbjct: 191 KRGGPPVKRAAEPPVVQPVPPAALSG--------------------------PSGEEGLS 224

Query: 646 PGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGL 705
           PG        G +     S +TG PPG     PP  P           P P PP  P  L
Sbjct: 225 PG--------GKRRRGCNSEQTGLPPGLPLPPPPLPP-----------PPPPPPPPPPPL 265

Query: 706 PSLPPPPAAPASGPPL---------------SATQIKQE-------------PAEEYETP 737
           P L   P    + P L               SA   +QE             PA     P
Sbjct: 266 PGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPP 325

Query: 738 ESPVPPARSPSPPPKVVDVPSH 759
              + PA  P P P+     SH
Sbjct: 326 GHRLVPAAPPGPGPRPPGAESH 347


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  125 bits (315), Expect = 2e-28
 Identities = 176/702 (25%), Positives = 240/702 (34%), Gaps = 164/702 (23%)

Query: 16  RKKEAPGPREELRSRG--RASPGGVSTSSSDGKAEKSRQTAKKA---RVEEASTPKVNKQ 70
           R K    P+    S G  R + G    + S   A +SR    +    R   ++ P+   +
Sbjct: 135 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 194

Query: 71  GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130
           G  + +S +    T  P          RP +   L     RSL+               S
Sbjct: 195 GPRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLS---------------S 235

Query: 131 TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP-----LFPPSPQPP--DSTPRQPEASF 183
           ++  + SP        S+ G  + PA P  P P     L PP   PP  D+ P     S 
Sbjct: 236 SATPLSSPA---RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 292

Query: 184 EPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG-----TGGVLSGPPMGPKGG 238
            P  + +P+   +P  PP+ +   +PP  PP       G      T   L  PP+ P   
Sbjct: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352

Query: 239 GAASSVGGPNGGKQHPPPTTP--ISVSSSGASGAPPTKPPTTPVGGGNLPSAP------- 289
                          PPP  P  +++    A  +PP  PP +P+   + P AP       
Sbjct: 353 ---------------PPPQAPPALALPPLQAPPSPPASPPLSPLATPS-PQAPNALAVHL 396

Query: 290 ------PPANFPHVTPNLPP--PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG 341
                 PP + P   P  PP  PP        S +PP L A PL    PSP A       
Sbjct: 397 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-PSPPASPPMSPS 455

Query: 342 LPPGPEKGPTLAPSPHSL----PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS 397
             P P+  P LA  P  L    P A  +   PP++            A  S  +S    +
Sbjct: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ------------ALPSPPASFPGQA 503

Query: 398 PFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457
           PF  S +LP  P + PPP +      PP    P L       Q PP PP    L A    
Sbjct: 504 PFSPSASLPMSPLATPPPQA------PPVLAAPLL-------QVPPSPPASPTLQAPRR- 549

Query: 458 HPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPH 517
                PP+ G  ++   P  T                              PPPP   P 
Sbjct: 550 -----PPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSRSPS 581

Query: 518 PLEGGSSHHAHPYAMSPSLGSLRPYPPGP----AHLPPPHSQVSYSQAGPNGPPVSSSSN 573
               G     H  + + +   LR Y  GP    A  PPP +++              ++ 
Sbjct: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAEL--------------AAC 627

Query: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA-SSPAGYKTAS 632
             ++ S+G  P   P   +G  GAP P+PP  T   S+  L T+  T    S      A 
Sbjct: 628 HPAAWSRGPAP---PLAFRGAPGAPLPWPPA-TGPGSADGLCTIYETEGPESATPAPGAL 683

Query: 633 PPGPPP---YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671
            PGP P    GK A   GA       G    SP   R G  P
Sbjct: 684 DPGPSPGTSGGKAAAGAGA-------GASSRSPKQARLGELP 718



 Score =  116 bits (291), Expect = 1e-25
 Identities = 166/655 (25%), Positives = 226/655 (34%), Gaps = 109/655 (16%)

Query: 155 PARPYHPPPLFPPSPQ---PPDSTPRQPEASF----------EPHPSVTPTGYHAPMEPP 201
           P  P  PPP+ P + +      +  R+P A            E  P   PT    P  P 
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP--PA 87

Query: 202 TSRMFQAPPGA-PPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPI 260
           + R  +APP     P P   PG   G     P+G KG   ++      G     P  + +
Sbjct: 88  SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 147

Query: 261 SVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNL-PPPPALRPLNNASASPPG 319
           S  +   +  P    P +P       +A      P   P+  P PP   P  + S++   
Sbjct: 148 SAGARRDTSGPTPGTP-SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206

Query: 320 LGAQPLPG-----------HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPA 368
              +P P              P+  ++      L      GP+   +P +  PA  S P 
Sbjct: 207 STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA--PAHPSQPK 264

Query: 369 P----PMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424
           P     +R P  +     AA +    SSS  A+P P++   PS       P SL     P
Sbjct: 265 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPS------APPSLQTLPSP 318

Query: 425 PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484
           P     + PSQA  S G P        L +    P   PP     + A PP+        
Sbjct: 319 P----ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL-------- 366

Query: 485 QQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP 544
                                   PP P A P PL    S  A P   +P+  +L  +  
Sbjct: 367 ----------------------QAPPSPPASP-PL----SPLATPSPQAPN--ALAVHLL 397

Query: 545 GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604
                PPP   V    + P  PPVS S+   S         + PS +  P   P P PP 
Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ--------APPSLAAPPLQVP-PSPPA 448

Query: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664
               + SAT         ++P       PP  PP             ATPP     SPP+
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP-----------ALATPPLQALPSPPA 497

Query: 665 FRTGTPPGYRGTSPPAGP-GTFKPGSPTVGPGPL--PPAGPSGLPSLPPPPAAPASGPPL 721
              G  P     S P  P  T  P +P V   PL   P  P   P+L  P   P  GP  
Sbjct: 498 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557

Query: 722 SATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776
           S +  +   A     P  P PP+RSPS      D+  H+S +    + L RG++S
Sbjct: 558 SVSGPRLTLA---LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 608



 Score =  115 bits (287), Expect = 3e-25
 Identities = 151/580 (26%), Positives = 202/580 (34%), Gaps = 65/580 (11%)

Query: 161 PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLY 220
           P P     P+PP   PR+  +S   H +  P+       P   R   A  G   P  +  
Sbjct: 181 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPS-------PAARRRPSAGGGLQRPASRSL 233

Query: 221 PGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQ------HPPPTTPISVSSSGASGAPPTK 274
                 + S    GP   G   +   P+  K        PP  TP    ++ A G   + 
Sbjct: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293

Query: 275 PPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHA 334
           P  TP      PSAPP  + P     LP PPA  P + A+ S      Q     LPSP  
Sbjct: 294 PLATPS-----PSAPPSPSAPPSLQTLPSPPATPP-SQATTSLGSPTLQATHSFLPSPPL 347

Query: 335 MGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSA-AASSSSSSSS 393
                    P P+  P LA  P   PP   S PA P   P ++ S  +  A +     + 
Sbjct: 348 SPLAT----PPPQAPPALALPPLQAPP---SPPASPPLSPLATPSPQAPNALAVHLLQAP 400

Query: 394 SSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA 453
            S  P P  QA P  P + PP   +S S  PP    PSL +  +  Q PP PP      A
Sbjct: 401 FSPPPSPPVQA-PFSPPASPP---VSPSATPPSQAPPSLAAPPL--QVPPSPP------A 448

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
           +    P   PP       A PP+           Q  +   Q           + P PP 
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPL-----------QLAKPPPQAPPALATPPLQALPSPPA 497

Query: 514 AFPH--PLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSS 571
           +FP   P    +S    P A  P      P    P    PP    S +   P  PP    
Sbjct: 498 SFPGQAPFSPSASLPMSPLATPPPQAP--PVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 555

Query: 572 SNSSSST--SQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK 629
             S S    +    P   P PS+ P       P +   ++S+ +    +    S P G  
Sbjct: 556 DTSVSGPRLTLALAPGPPPPPSRSPSST-LSGPDLAGHSSSATSTPEELRGYDSGPEGGA 614

Query: 630 TASPPGPPPYGKRAPSPGAYKTATPPGYK--PGSP----PSFRTGTPPGYRGTSPPAGPG 683
            ASPP         P+  +   A P  ++  PG+P    P+   G+  G        GP 
Sbjct: 615 AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE 674

Query: 684 TFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSA 723
           +  P    + PGP P  G SG  +     A  +S  P  A
Sbjct: 675 SATPAPGALDPGPSP--GTSGGKAAAGAGAGASSRSPKQA 712



 Score =  112 bits (281), Expect = 2e-24
 Identities = 148/525 (28%), Positives = 189/525 (36%), Gaps = 78/525 (14%)

Query: 247 PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPA 306
           P G  + PPP TP ++   GA+GA   KP     GG         A  P   P   P   
Sbjct: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG------GATIPESAPRAGPTRT 82

Query: 307 LRPLNNASASPPGLGAQPLPGHLPSP-HAMGQGMGGLPPGP--EKG------PTLAPSPH 357
            RP     AS  G  A P     P P  + G+  G   PGP  +KG       T+A    
Sbjct: 83  SRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKA 138

Query: 358 SLPPASSSAPAPPMRFPYSSS--SSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPP 415
           +  P  S+  A   R     +  + S A A  S ++ +    P PA  A P  P   P  
Sbjct: 139 TEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 198

Query: 416 TSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP 475
           +  S S      T+PS  ++   S G     P  R L++S A P   P  +G  +   P 
Sbjct: 199 SVSSASEHST--TEPSPAARRRPSAGGGLQRPASRSLSSS-ATPLSSPARSGPSARGTPR 255

Query: 476 VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPS 535
              H    + +  Q  +  Q             PP   A P      SS  A P   SPS
Sbjct: 256 APAHPSQPKPKGLQALRPPQVT-----------PPRKDAAPALGPLSSSPLATP---SPS 301

Query: 536 LGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQ 595
                  PP    LP P          P  PP  ++++  S T Q ++    PSP   P 
Sbjct: 302 APPSPSAPPSLQTLPSP----------PATPPSQATTSLGSPTLQATHSFL-PSPPLSPL 350

Query: 596 GAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA-PSPGAYKTAT- 653
             P P  P                   + P      SPP  PP    A PSP A      
Sbjct: 351 ATPPPQAP----------------PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAV 394

Query: 654 ----PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS---PTVGPGPLPPAGPSGLP 706
                P   P SPP     +PP     SP A P +  P S   P +   P PPA P   P
Sbjct: 395 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 454

Query: 707 SLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS-PSPP 750
           S  PPP AP   PPL+A  ++         P    PP ++ PSPP
Sbjct: 455 SATPPPQAP---PPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  124 bits (311), Expect = 5e-28
 Identities = 180/706 (25%), Positives = 234/706 (33%), Gaps = 126/706 (17%)

Query: 41   SSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQ 100
            + ++ ++  S    K++   +     +  +G++  I + E  +T    +TK   EL R  
Sbjct: 641  AETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLE--QTIEDLRTKIA-ELERQY 697

Query: 101  SPSDLDSLDGRSLNDDGSSDPRDIDQDN-RSTSPSIYSPGSVENDSDSSSGLSQGPARPY 159
               D +   G    ++G +   D+  +  R     +     +E  S  +S   +G     
Sbjct: 698  PALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTL 757

Query: 160  HPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQL 219
             P    P  P  P      P+  F    S+  +     ++  + +  Q+    PPP   L
Sbjct: 758  PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLL 817

Query: 220  YPGGTGGVLSGPPMGPKGGGAAS-----SVGGPNGGKQHPPPTTPISVSSSGASGAPPTK 274
            +  G G   S PP         S     S    N      PP  P + SSS   G     
Sbjct: 818  WSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVP 877

Query: 275  PPTTPVGGGNLPSAPPPANFPHVTP-----NLPPPPALRPLNNASASPPGLGAQPLPGH- 328
            PP  P+ G  +P+ P  A  P   P      LPPPP   PL  A   PP     PLPG  
Sbjct: 878  PPPPPLPGMTVPTLPSTA-IPQPPPLQGTEMLPPPPP--PLPGAGIPPP----PPLPGAG 930

Query: 329  -LPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASS 387
             LP P   G    G+PP P       P P  LP A    P PP+                
Sbjct: 931  ILPLPPLPG---AGIPPPPPLPGAAIPPPPPLPGAGIPLP-PPL---------------- 970

Query: 388  SSSSSSSSASPFPASQALPSYP---HSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPP 444
               +      P P +   P  P      PPP  L  +  PP    P LP   +    PPP
Sbjct: 971  -PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP---PPPLPGAGI----PPP 1022

Query: 445  PPPYGRLLANSNAHPG----PFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQ 500
            PP  G  +      PG    P PP  GA     PP+                        
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP----------------------- 1059

Query: 501  QQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQ 560
                G   PPPP     PL G       P    P  G   P P   A +PPP        
Sbjct: 1060 ----GAGIPPPP-----PLPGAGIPPPPPL---PGAGIPPPPPLPGAGIPPPPPLPGVGI 1107

Query: 561  AGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIAT 620
              P  PP+  +         G+     P P   P     P PP+P V             
Sbjct: 1108 PPP--PPLPGAGIPPPPPLPGA---GIPPPPPLPGAGIPPPPPLPRV------------G 1150

Query: 621  VASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPA 680
            +   P       PP PP  G   P P       P    P  PP    G PP      PP 
Sbjct: 1151 IPPPPPLPGAGIPPPPPLPGAGIPPP----PPLPGVGIPPPPPLPGVGIPP------PPP 1200

Query: 681  GPGTFKPGSPT-----VGPGPLPPAGPSGLPSLPPPPAAPASGPPL 721
             PG   P  P      + P P PP  P G   +PPPP  P SGPPL
Sbjct: 1201 LPGAGIPPPPPLPGMGIPPAPAPPLPPPG-TGIPPPPLLPVSGPPL 1245



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 141/529 (26%), Positives = 174/529 (32%), Gaps = 126/529 (23%)

Query: 94   QELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRST-----------SPSIYSPGSVE 142
            Q + +P  P  L  L        GS  P  I  + +++           S +I SP  + 
Sbjct: 805  QSISQPPPPPSL--LWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862

Query: 143  NDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPT 202
                SSS    G   P       PP P P  + P  P  +    P +  T    P  PP 
Sbjct: 863  CTESSSSMPGLGMVPP-------PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915

Query: 203  SRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTT---- 258
                   PGA  P P   PG   G+L  PP+   G G       P      PPP      
Sbjct: 916  -------PGAGIPPPPPLPGA--GILPLPPL--PGAGIPPPPPLPGAAIPPPPPLPGAGI 964

Query: 259  PISVSSSGASGAPPTK------PPTTPVGGGNLPSAPP--PANFPHVTP----NLPPPPA 306
            P+     GA   PP        PP  P+ G  +P  PP   A  P   P     +PPPP 
Sbjct: 965  PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP- 1023

Query: 307  LRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSA 366
              PL  A   PP     PLPG    P     G G  PP P  G  + P P    P +   
Sbjct: 1024 --PLPGAGIPPP----PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL--PGAGIP 1075

Query: 367  PAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPH---SFPPPTSLSVSNQ 423
            P PP+                   +      P P +   P  P      PPP  L  +  
Sbjct: 1076 PPPPL-----------------PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI 1118

Query: 424  PPKYTQPSL---PSQAVWSQGPPPPPPYGRL-LANSNAHPG----PFPPSTGAQSTAHPP 475
            PP    P     P   +   G PPPPP  R+ +      PG    P PP  GA     PP
Sbjct: 1119 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1178

Query: 476  VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG------AFPHPLEGGSSHHAHP 529
            +                            G   PPPP         P PL G       P
Sbjct: 1179 LP---------------------------GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPP 1211

Query: 530  YAMSPSLGSLRPYPPGPA-HLPPPHSQVSYSQAGP-NGPPVSSSSNSSS 576
                P +G     PP PA  LPPP + +      P +GPP+     SS+
Sbjct: 1212 L---PGMG----IPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSST 1253



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 145/523 (27%), Positives = 179/523 (34%), Gaps = 116/523 (22%)

Query: 277  TTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASA------SPPGLGAQPLPGHLP 330
            T+P   G + + PP    P   P  PP     P     +      SP  +  Q L  H P
Sbjct: 746  TSPTEEGGVLTLPPVDGLPG-RPPCPPGAESGPQTKFCSEISLIVSPRRISVQ-LDSHQP 803

Query: 331  SPHAMGQGMGGLPPGPEKGPTLAPS-PHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSS 389
            +     Q +   PP P    +     P S PP S S         + +S   S +++  +
Sbjct: 804  T-----QSISQPPPPPSLLWSAGQGQPGSQPPHSISTE-------FQTSHEHSVSSAFKN 851

Query: 390  SSSSSSASPFPASQALPSYPHSF---PPPTSLSVSNQPPKYTQPSLPSQAVWS----QG- 441
            S +  S  P P +++  S P      PPP  L      P  T P+LPS A+      QG 
Sbjct: 852  SCNIPSPPPLPCTESSSSMPGLGMVPPPPPPL------PGMTVPTLPSTAIPQPPPLQGT 905

Query: 442  ---PPPPPPY-GRLLANSNAHPG----PFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQ 493
               PPPPPP  G  +      PG    P PP  GA     PP+                 
Sbjct: 906  EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP---------------- 949

Query: 494  QQQQQQQQQHHGNSGPPPP---GA---FPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPA 547
                       G + PPPP   GA    P PL G       P    P  G   P P   A
Sbjct: 950  -----------GAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPL---PGAGIPPPPPLPGA 995

Query: 548  HLPPPHSQVSYSQAG-PNGPPVSSSSNSSSSTSQGS-YPCSHPSPSQG-PQGAPYP---F 601
             +PPP        AG P  PP+  +         G+  P   P P  G P   P P    
Sbjct: 996  GIPPPPPLPG---AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1052

Query: 602  PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTA--TPPGYKP 659
            PP P +           A +   P       PP PP  G   P P     A   PP   P
Sbjct: 1053 PPPPPLPG---------AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1103

Query: 660  G-----SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAA 714
            G      PP    G PP      PP  PG   P  P +    +PP  P     +PPPP  
Sbjct: 1104 GVGIPPPPPLPGAGIPP------PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPL 1157

Query: 715  PASG----PPLSATQIKQEPAEEYE--TPESPVPPARSPSPPP 751
            P +G    PPL    I   P        P  P+P    P PPP
Sbjct: 1158 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP 1200



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 66/237 (27%), Positives = 84/237 (35%), Gaps = 46/237 (19%)

Query: 161  PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP------GAPP 214
            PPP  P +  PP   P  P A   P P +   G   P  PP  R+   PP      G PP
Sbjct: 1109 PPPPLPGAGIPPP--PPLPGAGIPPPPPLPGAGIPPP--PPLPRVGIPPPPPLPGAGIPP 1164

Query: 215  PHPQLYPGG-------TGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGA 267
            P P   PG          GV   PP    G G       P  G   PPP   + +  + A
Sbjct: 1165 PPP--LPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPA 1222

Query: 268  SGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPG 327
               PP  PP T +        PPP   P     +  PP L  + +++   P      + G
Sbjct: 1223 ---PPLPPPGTGI--------PPPPLLP-----VSGPPLLPQVGSSTLPTP-----QVCG 1261

Query: 328  HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAA 384
             LP P  +  G+ GL    +KG    P    + P     P    R    S   SS +
Sbjct: 1262 FLPPP--LPSGLFGLGMNQDKGSRKQP----IEPCRPMKPLYWTRIQLHSKRDSSTS 1312



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 68/258 (26%), Positives = 89/258 (34%), Gaps = 28/258 (10%)

Query: 484 QQQQQQQQQQQQQQQQQQQHHGNSGP--PPPGAFPHPLEGGSSHHAHPYAMSPSLGS-LR 540
           QQQQQQ Q Q QQQQQQQQ  G   P  PP    P P   G+      + + PS G+   
Sbjct: 207 QQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQP---GAFLGLDRFLLGPSGGAGEA 263

Query: 541 PYPPGPAHLPPPHSQVSYSQAG-PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPY 599
           P  P         S +  S A  P  P    S      +   S P + P+    P    +
Sbjct: 264 PGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAF 323

Query: 600 PFPPV-PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYK 658
           PFP   P    + A +     T           +P G P   + AP             +
Sbjct: 324 PFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPG-EEWAP-------------E 369

Query: 659 PGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGP---GPLPPAGPSGLPSLPPPPAAP 715
            G     R G  P      P A      PGSP        P P   P  + +     ++P
Sbjct: 370 VGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSP 429

Query: 716 ASGP---PLSATQIKQEP 730
              P   P  + +IK+ P
Sbjct: 430 NHSPSQSPNQSPRIKRRP 447



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 65/275 (23%), Positives = 87/275 (31%), Gaps = 85/275 (30%)

Query: 485 QQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP 544
           QQQQQQQ Q Q QQQQQQ                L+G     A P A+S           
Sbjct: 206 QQQQQQQLQLQLQQQQQQQQ--------------LQGAEEPAAPPTAVS----------- 240

Query: 545 GPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPV 604
                P P + +   +                                GP G     P  
Sbjct: 241 -----PQPGAFLGLDRF-----------------------------LLGPSGGAGEAPGS 266

Query: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664
           P    + + LS +  ++A+ P       P  P       PSPG    +  P      P +
Sbjct: 267 PDTEQALSALSDLPESLAAEP-----REPQQP-------PSPGGLPVSEAPSLPAAQPAA 314

Query: 665 FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAG--------PSGLPSLPPPPAAPA 716
               +P       P AGPG    G+P  G G     G        P G P     P    
Sbjct: 315 --KDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGE 372

Query: 717 SGPPLSATQIKQEPAEEYETPESPVPPARSPSPPP 751
             P     ++ +EP EE + P++P   +   SP P
Sbjct: 373 DAP----QRLGEEPEEEAQGPDAPAAASLPGSPAP 403



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 45/159 (28%), Positives = 53/159 (33%), Gaps = 36/159 (22%)

Query: 852  PSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAV 911
            P LG VP  PP  PG  V T+P    P  P L+       P    PG    P   PL   
Sbjct: 871  PGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG-AGIPPPPPLPGA 929

Query: 912  D----PGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGV---- 963
                 P L G  +P      P                   PG  + P    P  G+    
Sbjct: 930  GILPLPPLPGAGIP---PPPPL------------------PGAAIPPPPPLPGAGIPLPP 968

Query: 964  --PGPGLDPFPRHGGLALQPGPP----GLHPFPFHPSLG 996
              PG G+ P P   G  + P PP    G+ P P  P  G
Sbjct: 969  PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1007



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 33/125 (26%), Positives = 46/125 (36%), Gaps = 32/125 (25%)

Query: 282 GGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG 341
           G   P+APP A  P        P A   L+     P G                  G G 
Sbjct: 228 GAEEPAAPPTAVSPQ-------PGAFLGLDRFLLGPSG------------------GAGE 262

Query: 342 LPPGPEKGPTLAPSPHSLPPASSSAPAPPMR------FPYSSSSSSSAAASSSSSSSSSS 395
            P  P+    L+ +   LP + ++ P  P +       P S + S  AA  ++  S SS+
Sbjct: 263 APGSPDTEQALS-ALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSST 321

Query: 396 ASPFP 400
           A PFP
Sbjct: 322 AFPFP 326


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  122 bits (306), Expect = 2e-27
 Identities = 147/533 (27%), Positives = 194/533 (36%), Gaps = 55/533 (10%)

Query: 247 PNGGKQHPPPTTPISVSSSGASGAPPTKPPTTP---VGGGNLPSAPPPANFPHVTPNLPP 303
           P G  + PPP TP ++   GA+GA   KP       +GG  +P + P A           
Sbjct: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 304 PPALRPLNNASASPPGLGAQPLPGHLPSP-HAMGQGMGGLPPGP--EKG------PTLAP 354
            PA RP     AS  G  A P     P P  + G+  G   PGP  +KG       T+A 
Sbjct: 89  NPASRP----PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144

Query: 355 SPHSLPPASSSAPAPPMRFPYSSS--SSSSAAASSSSSSSSSSASPFPASQALPSYPHSF 412
              +  P  S+  A   R     +  + S A A  S ++ +    P PA  A P  P   
Sbjct: 145 GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204

Query: 413 PPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTA 472
           P  +  S S      T+PS  ++   S G     P  R L++S A P   P  +G  +  
Sbjct: 205 PRKSVSSASEHST--TEPSPAARRRPSAGGGLQRPASRSLSSS-ATPLSSPARSGPSARG 261

Query: 473 HPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGP--PPPGAFPHPLEGGSSHHAHPY 530
            P    H    + +  Q  +  Q    ++      GP    P A P P     S      
Sbjct: 262 TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTL 321

Query: 531 AMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSH--- 587
             +P   SL      P  L PP      S      PP +  S +++S    +   +H   
Sbjct: 322 PATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 381

Query: 588 PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRA-PSP 646
           PSP   P   P P  P                   + P      SPP  PP    A PSP
Sbjct: 382 PSPPLSPLATPPPQAP----------------PALALPPLQAPPSPPASPPLSPLATPSP 425

Query: 647 GAYKTAT-----PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS---PTVGPGPLP 698
            A           P   P SPP     +PP     SP A P +  P S   P +   P P
Sbjct: 426 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 485

Query: 699 PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS-PSPP 750
           PA P   PS  PPP AP   PPL+A  ++         P    PP ++ PSPP
Sbjct: 486 PASPPMSPSATPPPQAP---PPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535



 Score =  117 bits (292), Expect = 8e-26
 Identities = 167/649 (25%), Positives = 225/649 (34%), Gaps = 111/649 (17%)

Query: 209 PPGAPPPHPQLYPG-----GTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVS 263
           PPG+P P P + P      G  G +   P+  + GG    +GG          T P S  
Sbjct: 29  PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG----IGGA---------TIPESAP 75

Query: 264 SSG---ASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPG- 319
            +G   ++G     P + P   G    APP         N  P P   P   +  + PG 
Sbjct: 76  RAGPTRSAGTSSRNPASRPPASGRGERAPP-------AKNTSPGPVSSPGRASGTTRPGP 128

Query: 320 LGAQPL------------PGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH---------- 357
           LG + L                P   A+  G      GP  G    PSP           
Sbjct: 129 LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPG---TPSPAMARRSRAAGT 185

Query: 358 --SLP-PASSSAPAPPMRFPYSSSSSSSAAASSSSSS------SSSSASPFPASQALPSY 408
              LP PA S+ P PP   P  S SS+S  +++  S       S+      PAS++L S 
Sbjct: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245

Query: 409 --PHSFPPPTSLSVSNQPPKYTQPSLPS----QAVWSQGPPPP-----PPYGRLLANSNA 457
             P S P  +  S    P     PS P     QA+      PP     P  G L ++  A
Sbjct: 246 ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 305

Query: 458 HPGPFPPSTGAQSTAHPPV-STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFP 516
            P P   S   QS A P + +T H      Q                   + P PP   P
Sbjct: 306 TPSP---SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPP 362

Query: 517 HP----LEGGSSHHAHPYAMSPSLGSLRPYPPG--PA-HLPPPHSQVSYSQAGPNGPPVS 569
                 L   +    H +  SP L  L   PP   PA  LPP  +  S   + P  P  +
Sbjct: 363 SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT 422

Query: 570 SSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK 629
            S  + ++ +          P   P  AP+  P  P V+ S+   S    ++A+ P    
Sbjct: 423 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 482

Query: 630 TASPPGPPPYGKRAPSPGA--------YKTATPPGYKP---GSPPSFRTGTPPGYRGTSP 678
            + P  PP      P P A         + A PP   P    +PP     +PP       
Sbjct: 483 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQA 542

Query: 679 PAGPGTFKPGSPTVGPGPLPPA-----------GPSGLPSLPPPPAAPASGPPLSATQIK 727
           P  P    P SP   P P  P             P   P+L  P   P  GP  S +  +
Sbjct: 543 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 602

Query: 728 QEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNS 776
              A     P  P PP+RSPS      D+  H+S +    + L RG++S
Sbjct: 603 LTLA---LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL-RGYDS 647



 Score =  116 bits (291), Expect = 1e-25
 Identities = 180/720 (25%), Positives = 242/720 (33%), Gaps = 170/720 (23%)

Query: 16  RKKEAPGPREELRSRG--RASPGGVSTSSSDGKAEKSRQTAKKA---RVEEASTPKVNKQ 70
           R K    P+    S G  R + G    + S   A +SR    +    R   ++ P+   +
Sbjct: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203

Query: 71  GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130
           G  + +S +    T  P          RP +   L     RSL+               S
Sbjct: 204 GPRKSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLS---------------S 244

Query: 131 TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP-----LFPPSPQPP--DSTPRQPEASF 183
           ++  + SP        S+ G  + PA P  P P     L PP   PP  D+ P     S 
Sbjct: 245 SATPLSSPA---RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 184 EPHPSVTPTGYHAPMEPPT----------SRMFQAPPGAPPPHPQLYPGGTGGVLSGPPM 233
            P  + +P+       PPT          +     P    PP P   P      L  PP 
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQ--TLPSPPA 359

Query: 234 GPKGGGAASSVGGPNGGKQH-------------PPPTTP--ISVSSSGASGAPPTKPPTT 278
            P    A +S+G P     H             PPP  P  +++    A  +PP  PP +
Sbjct: 360 TPPSQ-ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 418

Query: 279 PVGGGNLPSAP-------------PPANFPHVTPNLPP--PPALRPLNNASASPPGLGAQ 323
           P+   + P AP             PP + P   P  PP  PP        S +PP L A 
Sbjct: 419 PLATPS-PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 477

Query: 324 PLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSL----PPASSSAPAPPMRFPYSSSS 379
           PL    PSP A         P P+  P LA  P  L    P A  +   PP++       
Sbjct: 478 PLQVP-PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ------- 529

Query: 380 SSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWS 439
                A  S  +S    +PF  S +LP  P + PPP +      PP    P L       
Sbjct: 530 -----ALPSPPASFPGQAPFSPSASLPMSPLATPPPQA------PPVLAAPLL------- 571

Query: 440 QGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQ 499
           Q PP PP    L A         PP+ G  ++   P  T                     
Sbjct: 572 QVPPSPPASPTLQAPRR------PPTPGPDTSVSGPRLT--------------------- 604

Query: 500 QQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGP----AHLPPPHSQ 555
                    PPPP   P     G     H  + + +   LR Y  GP    A  PPP ++
Sbjct: 605 --LALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 662

Query: 556 VSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLS 615
           +              ++   ++ S+G  P   P   +G  GAP P+PP  T   S+  L 
Sbjct: 663 L--------------AACHPAAWSRGPAP---PLAFRGAPGAPLPWPPA-TGPGSADGLC 704

Query: 616 TVIATVA-SSPAGYKTASPPGPPP---YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671
           T+  T    S      A  PGP P    GK A   GA       G    SP   R G  P
Sbjct: 705 TIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA-------GASSRSPKQARLGELP 757



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 61/223 (27%), Positives = 77/223 (34%), Gaps = 20/223 (8%)

Query: 529 PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNG-----PPVSSSSNSSSSTSQGSY 583
           P A +P L  L P PPG    PPP +  +    G  G     P    +     +T   S 
Sbjct: 17  PAARAPGL--LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 584 PCSHPSPSQGPQGA-PYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKR 642
           P + P+ S G     P   PP       +           SSP      + PG  P G++
Sbjct: 75  PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG--PLGQK 132

Query: 643 APSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGP 702
                A +T      K    P     +    R TS P  PGT    SP +          
Sbjct: 133 GLRISAEETVARG--KATEAPKRSALSAGARRDTSGPT-PGT---PSPAMARRSRAAGTE 186

Query: 703 SGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPAR 745
            GLP  P P A P   PP    +     A E+ T E P P AR
Sbjct: 187 VGLPR-PAPSARPR--PPTEGPRKSVSSASEHSTTE-PSPAAR 225


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score =  119 bits (299), Expect = 1e-26
 Identities = 159/551 (28%), Positives = 207/551 (37%), Gaps = 90/551 (16%)

Query: 221  PGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA--PPTKPPTT 278
            P    G+ +  P G   G A S +GG +      P  TP +  ++ A GA  P      T
Sbjct: 1487 PTNIPGLGAAGPTGMFFGSAPSPMGGIS------PAMTPWNQGATPAYGAWSPSVGSGMT 1540

Query: 279  PVGGGNLPSAPPPAN--FPHVTPNLPPPPALRPLNNASASP--PGLGAQPLPGHLP-SPH 333
            P   G  PSA   A+   P  +P   P P   P +   +SP  P  G    P + P SP 
Sbjct: 1541 PGAAGFSPSAASDASGFSPGYSPAWSPTPG-SPGSPGPSSPYIPSPGGAMSPSYSPTSPA 1599

Query: 334  AMGQGMGGLPP-GPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSS 392
               +  GG  P  P   PT   SP   P + S +P  P   P S S S ++ + S +S S
Sbjct: 1600 YEPRSPGGYTPQSPSYSPT---SPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPS 1656

Query: 393  SSSASPFPASQALPSYPHSFPP--PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGR 450
             S  SP   S   PSY  + P   PTS S S   P Y+ P+ PS +      P  P Y  
Sbjct: 1657 YSPTSP-SYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS-PTSPSYS------PTSPSYS- 1707

Query: 451  LLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP 510
                      P  PS    S ++ P S  +                            P 
Sbjct: 1708 ----------PTSPSYSPTSPSYSPTSPSY---------------------------SPT 1730

Query: 511  PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
             P   P      +S    P + + S  S    P  P++ P   +  SYS   PN  P S 
Sbjct: 1731 SPSYSP------TSPSYSPTSPNYSPTSPNYTPTSPSYSP---TSPSYSPTSPNYTPTSP 1781

Query: 571  SSNSSSSTSQGSYPCSHP-SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK 629
            + + +S +   + P   P SPS  P    Y  P  PT T SS + S       SSP+ Y 
Sbjct: 1782 NYSPTSPSYSPTSPSYSPTSPSYSPSSPRYT-PQSPTYTPSSPSYSP------SSPS-YS 1833

Query: 630  TASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGT--FKP 687
              SP   P     +PS   Y T T P Y P SP    + T P Y  TSP   P T  + P
Sbjct: 1834 PTSPKYTPTSPSYSPSSPEY-TPTSPKYSPTSPKY--SPTSPKYSPTSPTYSPTTPKYSP 1890

Query: 688  GSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP 747
             SPT  P   P   P+     P  P    + P  S T     P     +  SP  P  SP
Sbjct: 1891 TSPTYSPTS-PVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSP 1949

Query: 748  SPPPKVVDVPS 758
            + P   +  P+
Sbjct: 1950 TSPTYSLTSPA 1960



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 81/282 (28%), Positives = 120/282 (42%), Gaps = 32/282 (11%)

Query: 505  GNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPG------PAHLP--PPHSQV 556
            G+ G P P +   P  GG+   ++    SP+  +  P  PG      P++ P  P +S  
Sbjct: 1570 GSPGSPGPSSPYIPSPGGAMSPSY----SPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPT 1625

Query: 557  S--YSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP-SPSQGPQGAPYPFPPVPTVTTSSAT 613
            S  YS   PN  P S S + +S +   + P   P SPS  P    Y  P  P+ + +S +
Sbjct: 1626 SPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS-PTSPSYSPTSPS 1684

Query: 614  LSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSP------PSFRT 667
             S    + + +   Y   SP   P     +P+  +Y + T P Y P SP      PS+ +
Sbjct: 1685 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSY-SPTSPSYSPTSPSYSPTSPSY-S 1742

Query: 668  GTPPGYRGTSP---PAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSAT 724
             T P Y  TSP   P  P ++ P SP+  P   P   P+     P  P+   + P  S T
Sbjct: 1743 PTSPNYSPTSPNYTPTSP-SYSPTSPSYSPTS-PNYTPTSPNYSPTSPSYSPTSPSYSPT 1800

Query: 725  QIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARF 766
                 P+    TP+SP     SPS  P     PS++  S ++
Sbjct: 1801 SPSYSPSSPRYTPQSPTYTPSSPSYSP---SSPSYSPTSPKY 1839



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 121/481 (25%), Positives = 170/481 (35%), Gaps = 63/481 (13%)

Query: 132  SPSIYS---PGSV---ENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEP 185
            SPS+ S   PG+     + +  +SG S G +  + P P  P SP P  S+P  P      
Sbjct: 1532 SPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGP--SSPYIPSPGGAM 1589

Query: 186  HPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVG 245
             PS +PT   +P   P S     P G  P  P   P       + P   P          
Sbjct: 1590 SPSYSPT---SPAYEPRS-----PGGYTPQSPSYSPTSPSYSPTSPSYSPT--------- 1632

Query: 246  GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPP--PANFPHVTPNLPP 303
             PN    + P +   S +S   S   P+  PT+P      PS  P  P+  P      P 
Sbjct: 1633 SPN----YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPT 1688

Query: 304  PPALRPLNNASASPPGLGAQPL-PGHLP-SPHAMGQGMGGLPPGPEKGPTLAPSPHSLPP 361
             P+  P  + S SP      P  P + P SP          P  P   PT   SP   P 
Sbjct: 1689 SPSYSP-TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPT---SPSYSPT 1744

Query: 362  ASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFP--PPTSLS 419
            + + +P  P   P S S S ++ + S +S + +  SP   S   PSY  + P   PTS S
Sbjct: 1745 SPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSP-NYSPTSPSYSPTSPSYSPTSPS 1803

Query: 420  VSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTH 479
             S   P+YT    P    ++   P   P     + ++    P  PS    S  + P S  
Sbjct: 1804 YSPSSPRYT----PQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPK 1859

Query: 480  HHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSL 539
            +     +      +               P  P   P   +   +   +    SP+    
Sbjct: 1860 YSPTSPKYSPTSPKY-------------SPTSPTYSPTTPKYSPTSPTY----SPTSPVY 1902

Query: 540  RPYPPGPAHLPPPHSQVS--YSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGA 597
             P  P  +   P +S  S  YS   P   P S   ++ S TS G  P S       P  +
Sbjct: 1903 TPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAIS 1962

Query: 598  P 598
            P
Sbjct: 1963 P 1963



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 102/389 (26%), Positives = 135/389 (34%), Gaps = 47/389 (12%)

Query: 99   PQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARP 158
            PQSPS   +    S      S        N S +   YSP S    S S +  S  P  P
Sbjct: 1610 PQSPSYSPTSPSYSPTSPSYSPT----SPNYSPTSPSYSPTS---PSYSPTSPSYSPTSP 1662

Query: 159  YHPPPLFPPSPQPPDSTPRQPEASFEP-HPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP 217
             + P     SP  P  +P  P  S+ P  PS +PT   +P   PTS      P   P  P
Sbjct: 1663 SYSPTSPSYSPTSPSYSPTSP--SYSPTSPSYSPT---SPSYSPTS------PSYSPTSP 1711

Query: 218  QLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPT 277
               P       + P   P                 + P +   S +S   S   P   PT
Sbjct: 1712 SYSPTSPSYSPTSPSYSPT-------------SPSYSPTSPSYSPTSPNYSPTSPNYTPT 1758

Query: 278  TPVGGGNLPS-APPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHLP-SPHA 334
            +P      PS +P   N+   +PN  P        + S SP      P  P + P SP  
Sbjct: 1759 SPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTY 1818

Query: 335  MGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSS 394
                    P  P   PT   SP   P + S +P+ P   P S   S ++   S +S   S
Sbjct: 1819 TPSSPSYSPSSPSYSPT---SPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYS 1875

Query: 395  SASPFPASQALPSYPHSFP--PPTSLSVSNQPPKYT------QPSLPSQAVWSQGPPPPP 446
              SP   S   P Y  + P   PTS   +   PKY+       P+ P  +  S    P  
Sbjct: 1876 PTSP-TYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTS 1934

Query: 447  PYGRLLANSNAHPGPFPPSTGAQSTAHPP 475
            P G   + ++    P  P+    S A  P
Sbjct: 1935 PKGSTYSPTSPGYSPTSPTYSLTSPAISP 1963



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 60/220 (27%), Positives = 81/220 (36%), Gaps = 42/220 (19%)

Query: 561  AGPNG-------PPVSSSSNSSSSTSQGSYPCSHP-SPSQGPQGAPYPFPPVPTVTTSSA 612
            AGP G        P+   S + +  +QG+ P     SPS G    P      P+  + ++
Sbjct: 1496 AGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDAS 1555

Query: 613  TLSTVIATVASSPAGYKTASPPGPP-PYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP 671
              S        SPA   T   PG P P     PSPG    A  P Y P         T P
Sbjct: 1556 GFSP-----GYSPAWSPTPGSPGSPGPSSPYIPSPGG---AMSPSYSP---------TSP 1598

Query: 672  GYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPA 731
             Y     P  PG + P SP+  P       PS  P+    P+   + P  S T     P 
Sbjct: 1599 AYE----PRSPGGYTPQSPSYSP-----TSPSYSPT---SPSYSPTSPNYSPTSPSYSPT 1646

Query: 732  EEYETPE----SPVPPARSPSPPPKVVDVPSHASQSARFN 767
                +P     SP  P+ SP+ P      PS++  S  ++
Sbjct: 1647 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS 1686


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  119 bits (297), Expect = 2e-26
 Identities = 183/744 (24%), Positives = 246/744 (33%), Gaps = 135/744 (18%)

Query: 93   EQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPS-----IYSPGSVENDS-- 145
            ++ L R +S  D  SL   S+    SS      Q N S             G V + S  
Sbjct: 514  QEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIV 573

Query: 146  ---------------DSSSGLSQGPARPYHPPPLFPP-SPQPPDSTPRQPEASFEPHPSV 189
                           +SS    +   RPY    L PP SPQP   TP        P P  
Sbjct: 574  SSVFSEAWKRGTQLEESSKARMESMNRPY--TSLVPPLSPQPKIVTPYTASQPSPPLPPP 631

Query: 190  TPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG 249
             P     P  PP       PP  PPP P L         S  PM  K     S++     
Sbjct: 632  PP-----PPPPP-------PPPPPPPPPPLPSQSAPSAGSAAPMFVK----YSTITRLQN 675

Query: 250  GKQHP-----PPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPP 304
              QH      PPT P+  S S        KP       G +P  PPP          PPP
Sbjct: 676  ASQHSGALFKPPTPPVMQSQS-------VKPQILVPPNGVVPPPPPP----------PPP 718

Query: 305  P----ALRPLNNASASP--PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS 358
            P    A+  L  A  +P  P   A P P  +     + Q     PP P       P P  
Sbjct: 719  PTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP------PIPAP 772

Query: 359  LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSL 418
            LPP    AP  P+    + +S+ + A   + ++  +   P P ++  P++P S+ PP   
Sbjct: 773  LPP---QAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPP--- 826

Query: 419  SVSNQPPKYTQPSLPSQAVWSQGPPPPP--PYGRLLAN--SNAHPGPFPPSTGAQSTAHP 474
            S    P     P+LP Q  +   PPP P  P   ++    S   P P PP+  +Q     
Sbjct: 827  SPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPV 886

Query: 475  PVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSP 534
            P +              Q     + + +   +S P P   FP P    S     P    P
Sbjct: 887  PANV-----------APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP---PP 932

Query: 535  SLGSLRPYPPGPAHLPPPHSQVS-------YSQAGPNGPPVSSSSNSSSSTSQGSYPCSH 587
            S     P PP P   P P    S        S  G   PP +   NSS  +S G+    H
Sbjct: 933  SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGA---EH 989

Query: 588  PSPSQGPQGAPYP--FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYG---KR 642
            P P +    +      PP  + + S  TL    A            + PG    G    +
Sbjct: 990  PEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAK 1049

Query: 643  AP------SPGAYKTATPPGYK--PGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGP 694
            AP           +  +PP     P  PP      PP      P    G   P    V P
Sbjct: 1050 APVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPI---EIPAVFSGNTSPKVAVVNP 1106

Query: 695  GPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVV 754
             P   +  S   + PP          L+  +I ++P      P+ P  P  S S  P  +
Sbjct: 1107 QPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFL 1166

Query: 755  ----------DVPSHASQSARFNK 768
                       +  H S S+R ++
Sbjct: 1167 ADLNRTLQRKSITRHGSLSSRMSR 1190



 Score = 30.8 bits (68), Expect = 8.0
 Identities = 33/116 (28%), Positives = 38/116 (32%), Gaps = 33/116 (28%)

Query: 673 YRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAE 732
           Y    PP  P   K  +P     P PP        LPPPP  P   PP            
Sbjct: 602 YTSLVPPLSPQP-KIVTPYTASQPSPP--------LPPPPPPP---PP------------ 637

Query: 733 EYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKH--LDRGFNSCARSDLYFVP 786
                  P PP   P PP      PS  S +  F K+  + R  N+   S   F P
Sbjct: 638 -------PPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKP 686


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score =  117 bits (293), Expect = 7e-26
 Identities = 172/785 (21%), Positives = 273/785 (34%), Gaps = 77/785 (9%)

Query: 49  KSRQTAKKARVEEASTPKVN---KQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
           K + T K   V+EA +   N   K    +  +   ++ + +PK T  +   PRP  P + 
Sbjct: 75  KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS 134

Query: 106 DSLDGRSL--NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP 163
           D+    SL  N + + + ++    N+ TS       +   ++ S    S     P     
Sbjct: 135 DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV- 193

Query: 164 LFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG 223
           L  P+P+  ++T + P  +    P  TPT    P EP ++      P  P P        
Sbjct: 194 LAKPTPKA-ETTTKGPALTTPKEP--TPT---TPKEPASTT-----PKEPTPT------- 235

Query: 224 TGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT---KPPTTPV 280
               +   P  PK     ++   P   K+  P TT     ++    AP T     PTT  
Sbjct: 236 ---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 292

Query: 281 GGGNLPSAPPPANFPHVTPNLPPPPA----LRPLNNASASPPGLGAQPLPGHLPSPHAMG 336
                P  P P       P  P  PA      P       P     +P P     P    
Sbjct: 293 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP---- 348

Query: 337 QGMGGLPPGPEK-GPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                 P  P+K  PT   +P    P +   PAP      S ++    A +++ S+ +++
Sbjct: 349 -----APTAPKKPAPT---TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 400

Query: 396 ASPFP-ASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA- 453
             P P  +++ P+ P    P T+   +   PK   P+ P +   +    P P   +  A 
Sbjct: 401 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 460

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
            +   P P  P   A +T      T          ++      ++          P  P 
Sbjct: 461 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 520

Query: 514 AFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN 573
             P P          P A +P+     P  P P     P      +   P  P  ++   
Sbjct: 521 E-PTPTTPEEPAPTTPKAAAPN----TPKEPAPTTPKEP------APTTPKEPAPTTPKE 569

Query: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASP 633
           ++ +T +G+ P +   P+      P P    PT TT   T +T      ++P G    +P
Sbjct: 570 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT-TTKEPTSTTCDKPAPTTPKGTAPTTP 628

Query: 634 PGPPPYGKRAPSPGAYKTATPPGYKPGSP-----PSFRTGTPPGYRG----TSPPAGPGT 684
             P P   + P+P   K   P   K  +P     P+ +   P   +G    TS    P T
Sbjct: 629 KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 688

Query: 685 FKPGSPTV--GPGPLPPAGPS-GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE-SP 740
            K  +PT    P P  P  P+   P  PPP  +  S P  +        + +  TPE S 
Sbjct: 689 PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748

Query: 741 VPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVP---LEGSKLAKKRA 797
            P  ++    PK   VP+  + +A   +      +     DL   P       K+ K+ A
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 808

Query: 798 DLVEK 802
              EK
Sbjct: 809 TTTEK 813



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 162/804 (20%), Positives = 254/804 (31%), Gaps = 99/804 (12%)

Query: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISES--ESEETNAPKKTKT 92
            P   +T S+    ++   T  K      +TPK      ++E + +  +S  T   +   T
Sbjct: 247  PAPTTTKSAPTTPKEPAPTTTKEPAP--TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 304

Query: 93   EQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLS 152
              + P P +P +      +        +P    ++   T+P   +P + +  +       
Sbjct: 305  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA------- 357

Query: 153  QGPARPYHPPPLFPPSPQP---------------PDSTPRQPEASFEPHPSVTPTGYHAP 197
              P  P  P P  P  P P               P +T   P  + EP P+ T +    P
Sbjct: 358  --PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 415

Query: 198  MEP-PTSRMFQAP--PGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254
             EP PT+    AP  P  P P     P  T      P    +     +    P   K+ P
Sbjct: 416  KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-P 474

Query: 255  PPTTPISVSSSGASGAPPTKP----PTTPVGGGNLPSAPPPANFPHVTPNLPPP--PALR 308
             PTTP   + +      PT P    PTTP      P+   P      TP  P P  P   
Sbjct: 475  APTTPKETAPTTPKKLTPTTPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEP 530

Query: 309  PLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGP-EKGPT----LAPSPHSLP-PA 362
                  A+ P    +P P   P   A        P  P E  PT     AP+    P P 
Sbjct: 531  APTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 589

Query: 363  SSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN 422
            +   PAP    P ++   +S      + ++    +P    +  P+ P    P T    + 
Sbjct: 590  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 649

Query: 423  QPPKYTQPSLPSQ-------AVWSQGP-------PPPPPYGRLLANSNAHPGPFPPSTGA 468
               K   P+ P +          ++GP       P P         +   P P  P   A
Sbjct: 650  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 709

Query: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528
             +T   P  T          ++     +   +     ++ P P      P E G      
Sbjct: 710  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 769

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P A  P + +          L    +    + A P     ++++   ++ S+ +   +  
Sbjct: 770  PAATKPEMTTTAKDKTTERDL---RTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 826

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGA 648
            + +      P+    + T TT +  ++T   T+ ++    K      P      +     
Sbjct: 827  TSTTTQDTTPFKITTLKT-TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS----- 880

Query: 649  YKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
             K  TP   KP   P   T T        P   P   KP +      P P    S +P L
Sbjct: 881  -KATTPKPQKPTKAPKKPTST------KKPKTMPRVRKPKTT-----PTPRKMTSTMPEL 928

Query: 709  PP----------PPAAPASGPPLSATQI--KQEPA--EEYETPESPV-PPARSPSPPPKV 753
             P              P   P     ++  K E A   E ETP   + P    P   P +
Sbjct: 929  NPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDM 988

Query: 754  VDVPSHASQSARFNKHLDRGFNSC 777
              +P   +Q    N  L    N C
Sbjct: 989  DYLPRVPNQGIIINPMLSDETNIC 1012


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score =  117 bits (293), Expect = 7e-26
 Identities = 172/785 (21%), Positives = 273/785 (34%), Gaps = 77/785 (9%)

Query: 49  KSRQTAKKARVEEASTPKVN---KQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
           K + T K   V+EA +   N   K    +  +   ++ + +PK T  +   PRP  P + 
Sbjct: 116 KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS 175

Query: 106 DSLDGRSL--NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP 163
           D+    SL  N + + + ++    N+ TS       +   ++ S    S     P     
Sbjct: 176 DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV- 234

Query: 164 LFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG 223
           L  P+P+  ++T + P  +    P  TPT    P EP ++      P  P P        
Sbjct: 235 LAKPTPKA-ETTTKGPALTTPKEP--TPT---TPKEPASTT-----PKEPTPT------- 276

Query: 224 TGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT---KPPTTPV 280
               +   P  PK     ++   P   K+  P TT     ++    AP T     PTT  
Sbjct: 277 ---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 333

Query: 281 GGGNLPSAPPPANFPHVTPNLPPPPA----LRPLNNASASPPGLGAQPLPGHLPSPHAMG 336
                P  P P       P  P  PA      P       P     +P P     P    
Sbjct: 334 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP---- 389

Query: 337 QGMGGLPPGPEK-GPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                 P  P+K  PT   +P    P +   PAP      S ++    A +++ S+ +++
Sbjct: 390 -----APTAPKKPAPT---TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 441

Query: 396 ASPFP-ASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA- 453
             P P  +++ P+ P    P T+   +   PK   P+ P +   +    P P   +  A 
Sbjct: 442 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 501

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
            +   P P  P   A +T      T          ++      ++          P  P 
Sbjct: 502 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 561

Query: 514 AFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN 573
             P P          P A +P+     P  P P     P      +   P  P  ++   
Sbjct: 562 E-PTPTTPEEPAPTTPKAAAPN----TPKEPAPTTPKEP------APTTPKEPAPTTPKE 610

Query: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASP 633
           ++ +T +G+ P +   P+      P P    PT TT   T +T      ++P G    +P
Sbjct: 611 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT-TTKEPTSTTCDKPAPTTPKGTAPTTP 669

Query: 634 PGPPPYGKRAPSPGAYKTATPPGYKPGSP-----PSFRTGTPPGYRG----TSPPAGPGT 684
             P P   + P+P   K   P   K  +P     P+ +   P   +G    TS    P T
Sbjct: 670 KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 729

Query: 685 FKPGSPTV--GPGPLPPAGPS-GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE-SP 740
            K  +PT    P P  P  P+   P  PPP  +  S P  +        + +  TPE S 
Sbjct: 730 PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789

Query: 741 VPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVP---LEGSKLAKKRA 797
            P  ++    PK   VP+  + +A   +      +     DL   P       K+ K+ A
Sbjct: 790 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 849

Query: 798 DLVEK 802
              EK
Sbjct: 850 TTTEK 854



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 162/804 (20%), Positives = 254/804 (31%), Gaps = 99/804 (12%)

Query: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISES--ESEETNAPKKTKT 92
            P   +T S+    ++   T  K      +TPK      ++E + +  +S  T   +   T
Sbjct: 288  PAPTTTKSAPTTPKEPAPTTTKEPAP--TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 345

Query: 93   EQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLS 152
              + P P +P +      +        +P    ++   T+P   +P + +  +       
Sbjct: 346  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA------- 398

Query: 153  QGPARPYHPPPLFPPSPQP---------------PDSTPRQPEASFEPHPSVTPTGYHAP 197
              P  P  P P  P  P P               P +T   P  + EP P+ T +    P
Sbjct: 399  --PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 456

Query: 198  MEP-PTSRMFQAP--PGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254
             EP PT+    AP  P  P P     P  T      P    +     +    P   K+ P
Sbjct: 457  KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-P 515

Query: 255  PPTTPISVSSSGASGAPPTKP----PTTPVGGGNLPSAPPPANFPHVTPNLPPP--PALR 308
             PTTP   + +      PT P    PTTP      P+   P      TP  P P  P   
Sbjct: 516  APTTPKETAPTTPKKLTPTTPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEP 571

Query: 309  PLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGP-EKGPT----LAPSPHSLP-PA 362
                  A+ P    +P P   P   A        P  P E  PT     AP+    P P 
Sbjct: 572  APTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 630

Query: 363  SSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN 422
            +   PAP    P ++   +S      + ++    +P    +  P+ P    P T    + 
Sbjct: 631  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 690

Query: 423  QPPKYTQPSLPSQ-------AVWSQGP-------PPPPPYGRLLANSNAHPGPFPPSTGA 468
               K   P+ P +          ++GP       P P         +   P P  P   A
Sbjct: 691  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 750

Query: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528
             +T   P  T          ++     +   +     ++ P P      P E G      
Sbjct: 751  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 810

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P A  P + +          L    +    + A P     ++++   ++ S+ +   +  
Sbjct: 811  PAATKPEMTTTAKDKTTERDL---RTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 867

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGA 648
            + +      P+    + T TT +  ++T   T+ ++    K      P      +     
Sbjct: 868  TSTTTQDTTPFKITTLKT-TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS----- 921

Query: 649  YKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
             K  TP   KP   P   T T        P   P   KP +      P P    S +P L
Sbjct: 922  -KATTPKPQKPTKAPKKPTST------KKPKTMPRVRKPKTT-----PTPRKMTSTMPEL 969

Query: 709  PP----------PPAAPASGPPLSATQI--KQEPA--EEYETPESPV-PPARSPSPPPKV 753
             P              P   P     ++  K E A   E ETP   + P    P   P +
Sbjct: 970  NPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDM 1029

Query: 754  VDVPSHASQSARFNKHLDRGFNSC 777
              +P   +Q    N  L    N C
Sbjct: 1030 DYLPRVPNQGIIINPMLSDETNIC 1053


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  117 bits (293), Expect = 7e-26
 Identities = 172/785 (21%), Positives = 273/785 (34%), Gaps = 77/785 (9%)

Query: 49  KSRQTAKKARVEEASTPKVN---KQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
           K + T K   V+EA +   N   K    +  +   ++ + +PK T  +   PRP  P + 
Sbjct: 168 KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS 227

Query: 106 DSLDGRSL--NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP 163
           D+    SL  N + + + ++    N+ TS       +   ++ S    S     P     
Sbjct: 228 DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV- 286

Query: 164 LFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG 223
           L  P+P+  ++T + P  +    P  TPT    P EP ++      P  P P        
Sbjct: 287 LAKPTPKA-ETTTKGPALTTPKEP--TPT---TPKEPASTT-----PKEPTPT------- 328

Query: 224 TGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT---KPPTTPV 280
               +   P  PK     ++   P   K+  P TT     ++    AP T     PTT  
Sbjct: 329 ---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 385

Query: 281 GGGNLPSAPPPANFPHVTPNLPPPPA----LRPLNNASASPPGLGAQPLPGHLPSPHAMG 336
                P  P P       P  P  PA      P       P     +P P     P    
Sbjct: 386 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP---- 441

Query: 337 QGMGGLPPGPEK-GPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                 P  P+K  PT   +P    P +   PAP      S ++    A +++ S+ +++
Sbjct: 442 -----APTAPKKPAPT---TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 396 ASPFP-ASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA- 453
             P P  +++ P+ P    P T+   +   PK   P+ P +   +    P P   +  A 
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
            +   P P  P   A +T      T          ++      ++          P  P 
Sbjct: 554 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 613

Query: 514 AFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN 573
             P P          P A +P+     P  P P     P      +   P  P  ++   
Sbjct: 614 E-PTPTTPEEPAPTTPKAAAPN----TPKEPAPTTPKEP------APTTPKEPAPTTPKE 662

Query: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASP 633
           ++ +T +G+ P +   P+      P P    PT TT   T +T      ++P G    +P
Sbjct: 663 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT-TTKEPTSTTCDKPAPTTPKGTAPTTP 721

Query: 634 PGPPPYGKRAPSPGAYKTATPPGYKPGSP-----PSFRTGTPPGYRG----TSPPAGPGT 684
             P P   + P+P   K   P   K  +P     P+ +   P   +G    TS    P T
Sbjct: 722 KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 781

Query: 685 FKPGSPTV--GPGPLPPAGPS-GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE-SP 740
            K  +PT    P P  P  P+   P  PPP  +  S P  +        + +  TPE S 
Sbjct: 782 PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 841

Query: 741 VPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVP---LEGSKLAKKRA 797
            P  ++    PK   VP+  + +A   +      +     DL   P       K+ K+ A
Sbjct: 842 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 901

Query: 798 DLVEK 802
              EK
Sbjct: 902 TTTEK 906



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 162/804 (20%), Positives = 254/804 (31%), Gaps = 99/804 (12%)

Query: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISES--ESEETNAPKKTKT 92
            P   +T S+    ++   T  K      +TPK      ++E + +  +S  T   +   T
Sbjct: 340  PAPTTTKSAPTTPKEPAPTTTKEPAP--TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 397

Query: 93   EQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLS 152
              + P P +P +      +        +P    ++   T+P   +P + +  +       
Sbjct: 398  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA------- 450

Query: 153  QGPARPYHPPPLFPPSPQP---------------PDSTPRQPEASFEPHPSVTPTGYHAP 197
              P  P  P P  P  P P               P +T   P  + EP P+ T +    P
Sbjct: 451  --PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 508

Query: 198  MEP-PTSRMFQAP--PGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254
             EP PT+    AP  P  P P     P  T      P    +     +    P   K+ P
Sbjct: 509  KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-P 567

Query: 255  PPTTPISVSSSGASGAPPTKP----PTTPVGGGNLPSAPPPANFPHVTPNLPPP--PALR 308
             PTTP   + +      PT P    PTTP      P+   P      TP  P P  P   
Sbjct: 568  APTTPKETAPTTPKKLTPTTPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEP 623

Query: 309  PLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGP-EKGPT----LAPSPHSLP-PA 362
                  A+ P    +P P   P   A        P  P E  PT     AP+    P P 
Sbjct: 624  APTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 682

Query: 363  SSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN 422
            +   PAP    P ++   +S      + ++    +P    +  P+ P    P T    + 
Sbjct: 683  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 742

Query: 423  QPPKYTQPSLPSQ-------AVWSQGP-------PPPPPYGRLLANSNAHPGPFPPSTGA 468
               K   P+ P +          ++GP       P P         +   P P  P   A
Sbjct: 743  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 802

Query: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528
             +T   P  T          ++     +   +     ++ P P      P E G      
Sbjct: 803  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 862

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P A  P + +          L    +    + A P     ++++   ++ S+ +   +  
Sbjct: 863  PAATKPEMTTTAKDKTTERDL---RTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 919

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGA 648
            + +      P+    + T TT +  ++T   T+ ++    K      P      +     
Sbjct: 920  TSTTTQDTTPFKITTLKT-TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS----- 973

Query: 649  YKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
             K  TP   KP   P   T T        P   P   KP +      P P    S +P L
Sbjct: 974  -KATTPKPQKPTKAPKKPTST------KKPKTMPRVRKPKTT-----PTPRKMTSTMPEL 1021

Query: 709  PP----------PPAAPASGPPLSATQI--KQEPA--EEYETPESPV-PPARSPSPPPKV 753
             P              P   P     ++  K E A   E ETP   + P    P   P +
Sbjct: 1022 NPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDM 1081

Query: 754  VDVPSHASQSARFNKHLDRGFNSC 777
              +P   +Q    N  L    N C
Sbjct: 1082 DYLPRVPNQGIIINPMLSDETNIC 1105



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 84/427 (19%), Positives = 146/427 (34%), Gaps = 79/427 (18%)

Query: 387 SSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPP 446
           +S  SS  +  P  ASQ + S     P P +        K T+  + S+ +  +      
Sbjct: 70  TSPPSSKKAPPPSGASQTIKSTTKRSPKPPN-------KKKTKKVIESEEITEEHS---- 118

Query: 447 PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGN 506
                  + N        S+ + ST     S+ +    ++ Q++ + +  ++ + +    
Sbjct: 119 ------VSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPT 172

Query: 507 SGPPPPGAFPHPLEGG---------SSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVS 557
             PP        L+ G         S+   +  + SP + + +P  P P+   PP+S  S
Sbjct: 173 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL--PPNSDTS 230

Query: 558 YS---------------------QAGPNGPPVSSSSNSSSSTSQGSYP--------CSHP 588
                                  Q   +G   ++S+  + S  + S           + P
Sbjct: 231 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 290

Query: 589 SP-----SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGP-----PP 638
           +P     ++GP     P  P PT     A+ +    T  +  +   T   P P      P
Sbjct: 291 TPKAETTTKGP-ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 349

Query: 639 YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLP 698
              + P+P   K   P   K  +P + +   P     T+  + P T K  +PT    P P
Sbjct: 350 TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-----TTTKSAPTTPKEPAPTTPKKPAP 404

Query: 699 PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPA-RSPSPPPKVVDVP 757
                  P+ P  P       P   T   +EPA    TP+ P P A + P+P       P
Sbjct: 405 TTPKEPAPTTPKEPTPTTPKEPAPTT---KEPAP--TTPKEPAPTAPKKPAPTTPKEPAP 459

Query: 758 SHASQSA 764
           +   + A
Sbjct: 460 TTPKEPA 466


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  117 bits (293), Expect = 7e-26
 Identities = 172/785 (21%), Positives = 273/785 (34%), Gaps = 77/785 (9%)

Query: 49  KSRQTAKKARVEEASTPKVN---KQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
           K + T K   V+EA +   N   K    +  +   ++ + +PK T  +   PRP  P + 
Sbjct: 209 KKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNS 268

Query: 106 DSLDGRSL--NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPP 163
           D+    SL  N + + + ++    N+ TS       +   ++ S    S     P     
Sbjct: 269 DTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV- 327

Query: 164 LFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGG 223
           L  P+P+  ++T + P  +    P  TPT    P EP ++      P  P P        
Sbjct: 328 LAKPTPKA-ETTTKGPALTTPKEP--TPT---TPKEPASTT-----PKEPTPT------- 369

Query: 224 TGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT---KPPTTPV 280
               +   P  PK     ++   P   K+  P TT     ++    AP T     PTT  
Sbjct: 370 ---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 426

Query: 281 GGGNLPSAPPPANFPHVTPNLPPPPA----LRPLNNASASPPGLGAQPLPGHLPSPHAMG 336
                P  P P       P  P  PA      P       P     +P P     P    
Sbjct: 427 SAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP---- 482

Query: 337 QGMGGLPPGPEK-GPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                 P  P+K  PT   +P    P +   PAP      S ++    A +++ S+ +++
Sbjct: 483 -----APTAPKKPAPT---TPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 396 ASPFP-ASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA- 453
             P P  +++ P+ P    P T+   +   PK   P+ P +   +    P P   +  A 
Sbjct: 535 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
            +   P P  P   A +T      T          ++      ++          P  P 
Sbjct: 595 TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 654

Query: 514 AFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN 573
             P P          P A +P+     P  P P     P      +   P  P  ++   
Sbjct: 655 E-PTPTTPEEPAPTTPKAAAPN----TPKEPAPTTPKEP------APTTPKEPAPTTPKE 703

Query: 574 SSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASP 633
           ++ +T +G+ P +   P+      P P    PT TT   T +T      ++P G    +P
Sbjct: 704 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT-TTKEPTSTTCDKPAPTTPKGTAPTTP 762

Query: 634 PGPPPYGKRAPSPGAYKTATPPGYKPGSP-----PSFRTGTPPGYRG----TSPPAGPGT 684
             P P   + P+P   K   P   K  +P     P+ +   P   +G    TS    P T
Sbjct: 763 KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT 822

Query: 685 FKPGSPTV--GPGPLPPAGPS-GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE-SP 740
            K  +PT    P P  P  P+   P  PPP  +  S P  +        + +  TPE S 
Sbjct: 823 PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 882

Query: 741 VPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVP---LEGSKLAKKRA 797
            P  ++    PK   VP+  + +A   +      +     DL   P       K+ K+ A
Sbjct: 883 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 942

Query: 798 DLVEK 802
              EK
Sbjct: 943 TTTEK 947



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 162/804 (20%), Positives = 254/804 (31%), Gaps = 99/804 (12%)

Query: 35   PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISES--ESEETNAPKKTKT 92
            P   +T S+    ++   T  K      +TPK      ++E + +  +S  T   +   T
Sbjct: 381  PAPTTTKSAPTTPKEPAPTTTKEPAP--TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 438

Query: 93   EQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLS 152
              + P P +P +      +        +P    ++   T+P   +P + +  +       
Sbjct: 439  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA------- 491

Query: 153  QGPARPYHPPPLFPPSPQP---------------PDSTPRQPEASFEPHPSVTPTGYHAP 197
              P  P  P P  P  P P               P +T   P  + EP P+ T +    P
Sbjct: 492  --PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 549

Query: 198  MEP-PTSRMFQAP--PGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254
             EP PT+    AP  P  P P     P  T      P    +     +    P   K+ P
Sbjct: 550  KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE-P 608

Query: 255  PPTTPISVSSSGASGAPPTKP----PTTPVGGGNLPSAPPPANFPHVTPNLPPP--PALR 308
             PTTP   + +      PT P    PTTP      P+   P      TP  P P  P   
Sbjct: 609  APTTPKETAPTTPKKLTPTTPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEP 664

Query: 309  PLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGP-EKGPT----LAPSPHSLP-PA 362
                  A+ P    +P P   P   A        P  P E  PT     AP+    P P 
Sbjct: 665  APTTPKAAAPNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 723

Query: 363  SSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN 422
            +   PAP    P ++   +S      + ++    +P    +  P+ P    P T    + 
Sbjct: 724  TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 783

Query: 423  QPPKYTQPSLPSQ-------AVWSQGP-------PPPPPYGRLLANSNAHPGPFPPSTGA 468
               K   P+ P +          ++GP       P P         +   P P  P   A
Sbjct: 784  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 843

Query: 469  QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528
             +T   P  T          ++     +   +     ++ P P      P E G      
Sbjct: 844  PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKT 903

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P A  P + +          L    +    + A P     ++++   ++ S+ +   +  
Sbjct: 904  PAATKPEMTTTAKDKTTERDL---RTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 960

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGA 648
            + +      P+    + T TT +  ++T   T+ ++    K      P      +     
Sbjct: 961  TSTTTQDTTPFKITTLKT-TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNS----- 1014

Query: 649  YKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708
             K  TP   KP   P   T T        P   P   KP +      P P    S +P L
Sbjct: 1015 -KATTPKPQKPTKAPKKPTST------KKPKTMPRVRKPKTT-----PTPRKMTSTMPEL 1062

Query: 709  PP----------PPAAPASGPPLSATQI--KQEPA--EEYETPESPV-PPARSPSPPPKV 753
             P              P   P     ++  K E A   E ETP   + P    P   P +
Sbjct: 1063 NPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDM 1122

Query: 754  VDVPSHASQSARFNKHLDRGFNSC 777
              +P   +Q    N  L    N C
Sbjct: 1123 DYLPRVPNQGIIINPMLSDETNIC 1146



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 84/427 (19%), Positives = 146/427 (34%), Gaps = 79/427 (18%)

Query: 387 SSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPP 446
           +S  SS  +  P  ASQ + S     P P +        K T+  + S+ +  +      
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPN-------KKKTKKVIESEEITEEHS---- 159

Query: 447 PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGN 506
                  + N        S+ + ST     S+ +    ++ Q++ + +  ++ + +    
Sbjct: 160 ------VSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPT 213

Query: 507 SGPPPPGAFPHPLEGG---------SSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVS 557
             PP        L+ G         S+   +  + SP + + +P  P P+   PP+S  S
Sbjct: 214 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSL--PPNSDTS 271

Query: 558 YS---------------------QAGPNGPPVSSSSNSSSSTSQGSYP--------CSHP 588
                                  Q   +G   ++S+  + S  + S           + P
Sbjct: 272 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 331

Query: 589 SP-----SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGP-----PP 638
           +P     ++GP     P  P PT     A+ +    T  +  +   T   P P      P
Sbjct: 332 TPKAETTTKGP-ALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAP 390

Query: 639 YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLP 698
              + P+P   K   P   K  +P + +   P     T+  + P T K  +PT    P P
Sbjct: 391 TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-----TTTKSAPTTPKEPAPTTPKKPAP 445

Query: 699 PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPA-RSPSPPPKVVDVP 757
                  P+ P  P       P   T   +EPA    TP+ P P A + P+P       P
Sbjct: 446 TTPKEPAPTTPKEPTPTTPKEPAPTT---KEPAP--TTPKEPAPTAPKKPAPTTPKEPAP 500

Query: 758 SHASQSA 764
           +   + A
Sbjct: 501 TTPKEPA 507


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score =  116 bits (290), Expect = 1e-25
 Identities = 222/851 (26%), Positives = 287/851 (33%), Gaps = 175/851 (20%)

Query: 131 TSPSIYSPGSVENDSDSSSGLSQGPARP--YHPPPLFPPSPQPPDSTPR------QPEAS 182
           T+P    PGS+  +  S S      A P    PP L  P P    S+PR       P  +
Sbjct: 154 TTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPA 213

Query: 183 FEPHPSV-----------------------TPTGYHA----PMEPPTSRMFQA--PPGAP 213
             P P++                       +P   HA    P +PP      A  PP  P
Sbjct: 214 PPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLP 273

Query: 214 P-------PHPQLYPGGTGGVLSGP-PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSS 265
           P       P P   P  +   +  P  +GP GG  A +V GP      PP      +S++
Sbjct: 274 PSNNLPAHPGPASQPPVSSATMHLPLVLGPLGG--APTVEGPGA----PPFLASSLLSAA 327

Query: 266 GASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN----LPPPPALRPLNNASASPPGLG 321
             +  PP  PP+T  G      AP  ++   + P+      PP   R L       P   
Sbjct: 328 AKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRS 387

Query: 322 AQPLPGHLPSPHAMGQ----------GMGGLP-PGPEKGP----TLAPSPHSLPPASSSA 366
               P  +P P ++ +           + GLP PGP         L    H  PP + S+
Sbjct: 388 RPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSS 447

Query: 367 PAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSF--PPPTSLSVSNQP 424
            +PP   P      S    +S S SS   A   PA+   P  P      P   L +   P
Sbjct: 448 GSPPQ--PRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGP 505

Query: 425 PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGA----QSTAHPPVSTHH 480
                  LP  A     P P P  G  L+ +      FP   GA     S   PP S   
Sbjct: 506 ----ACPLPPLAGGEAFPFPSPEQGLALSGAG-----FPGMLGALPLPLSLGQPPPSPLL 556

Query: 481 HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSL--GS 538
           +H                      G  G PPP     P  G     A      PSL   S
Sbjct: 557 NHSLFGVLT---------------GGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVAS 601

Query: 539 LRPYPPG----PAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGP 594
           L P PP     P   PP +   S+      GP   ++ +   S      P   P    G 
Sbjct: 602 LLPPPPSDLLPPPSAPPSNLLASFLPLLALGP---TAGDGEGSAEGAGGPSGEPFSGLGD 658

Query: 595 QGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSP--GAYKTA 652
             +P  FPP+    T  A  S ++A     P+G    +PP P       P P   +  TA
Sbjct: 659 L-SPLLFPPLSAPPTLIALNSALLAATLDPPSG----TPPQPCVLSAPQPGPPTSSVTTA 713

Query: 653 T--PPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKP-GSPTVGPGPLP----PAGP--- 702
           T  P     G  PS  +G PP  +  SP  G        S T  PG LP    P GP   
Sbjct: 714 TTDPGASSLGKAPS-NSGRPP--QLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLS 770

Query: 703 --SGLPSLP----PPPAAPASGPPLSATQIKQEPAEEYET----PESP------------ 740
              GL  LP    PPP + AS P     Q  Q P E+ E     PESP            
Sbjct: 771 GQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPP 830

Query: 741 ----VPPARSPSPP-PKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKK 795
                PP  SP PP P+++       +  R    L RG N  AR      P  G K    
Sbjct: 831 LSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGL-RGINGEAR------PARGRKPGS- 882

Query: 796 RADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLG 855
                   RRE  + A +   R      + ER   +    + + +LA+ G  P + P  G
Sbjct: 883 --------RREPGRLALKWGTR-GGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPG 933

Query: 856 PVPHRPPFEPG 866
           P        PG
Sbjct: 934 PHSEDLKVPPG 944



 Score =  107 bits (267), Expect = 7e-23
 Identities = 146/511 (28%), Positives = 197/511 (38%), Gaps = 81/511 (15%)

Query: 261 SVSSSGASGAPPTK-PPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPG 319
           +VS    S  PP + PPTTP+ GG     P P +     P L  P  L P   A   P G
Sbjct: 137 TVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSG 196

Query: 320 LGAQP--LP-GHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH-------SLPPASSSAPAP 369
             + P  LP G+ PSP          PP P      APS +       SL P+   +P  
Sbjct: 197 GSSSPRFLPRGNAPSP---------APPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPA 247

Query: 370 PMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQ 429
           P      +SSS  +       S + +  P P S  LP++P     P   S +   P    
Sbjct: 248 P-----HASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLG 302

Query: 430 PSLPSQAVWSQGPPPPPPYGRLLANSNA-HPGPFPPST--GAQSTAHPPVSTHHHHHQQQ 486
           P   +  V   G PP      L A + A HP   PPST  G +  A  P ++H    +  
Sbjct: 303 PLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPS 362

Query: 487 QQQQQQQ----QQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPY 542
           Q++ ++     +  + +  Q    S P  P   P P     S       + PS+ SL   
Sbjct: 363 QRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPF----SLPEPSQPILPSVLSLLGL 418

Query: 543 P-PGP-------------AHLPPPHSQVSYSQAGPNGP-----PVSSSSNSSSSTSQGSY 583
           P PGP             AHLPPP +  S S   P  P     P ++S + SS     + 
Sbjct: 419 PTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAP 478

Query: 584 PCSH----------PSPSQGPQGAPYPFPPVPTVTTSSA-TLSTVIATVASSPAGY--KT 630
           P +            SPS+G      P  P+P +    A    +    +A S AG+    
Sbjct: 479 PAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGML 538

Query: 631 ASPPGPPPYGKRAPSP----GAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFK 686
            + P P   G+  PSP      +   T  G   G PP      PPG  G  PP  PG  +
Sbjct: 539 GALPLPLSLGQPPPSPLLNHSLFGVLTGGG---GQPPPEPLLPPPG--GPGPPLAPG--E 591

Query: 687 PGSPTVGPGPLPPAGPSGLPSLPPPPAAPAS 717
           P  P++    L P  PS L  LPPP A P++
Sbjct: 592 PEGPSLLVASLLPPPPSDL--LPPPSAPPSN 620



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 165/643 (25%), Positives = 212/643 (32%), Gaps = 91/643 (14%)

Query: 156 ARPYHPPPLFPPSPQPPDSTPRQPEA-SFEPHPSVTPT---------GYHAPMEPPTSRM 205
           +RP  P P+  P   P  S P  P   S    P+  P+         G  A + PP +  
Sbjct: 387 SRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLS 446

Query: 206 FQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSS 265
             +PP    P     PG T G LS  P  P    A+ +   P+   Q P        S  
Sbjct: 447 SGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSP--------SEG 498

Query: 266 GASGAPPTKPPTTPVGGGNLPSAPPP--------ANFPHVTPNLP-------PPPALRPL 310
              GA P   P  P+ GG     P P        A FP +   LP       PPP+  PL
Sbjct: 499 LGMGAGPA-CPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPS--PL 555

Query: 311 NNAS--ASPPGLGAQPLPGH-LPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAP 367
            N S      G G QP P   LP P   G     L PG  +GP+L  +    PP S   P
Sbjct: 556 LNHSLFGVLTGGGGQPPPEPLLPPPGGPGP---PLAPGEPEGPSLLVASLLPPPPSDLLP 612

Query: 368 ---APPMRFPYS----SSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSV 420
              APP     S     +   +A     S+  +   S  P S      P  FPP ++   
Sbjct: 613 PPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSA--- 669

Query: 421 SNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHH 480
              PP     +    A     P   PP   +L  S   PGP P S+   +T  P  S+  
Sbjct: 670 ---PPTLIALNSALLAATLDPPSGTPPQPCVL--SAPQPGP-PTSSVTTATTDPGASSLG 723

Query: 481 HHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540
                  +  Q              +S    PGA P  L+           +S  LG L+
Sbjct: 724 KAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGP------LLSGQLG-LQ 776

Query: 541 PYPPGPAHLPPPHSQVSYS--------QAGPNGPPVSSSSNSSSSTSQGSYPCSHP-SPS 591
             P G A  PPP S+ S          Q  P  P        S +++    P   P S  
Sbjct: 777 LLPGGGA--PPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSAL 834

Query: 592 QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPP-GPPPYGKRAPSPGAYK 650
             P G+  P PPVP + T   +                 A P  G  P  +R P   A K
Sbjct: 835 APPHGS--PDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALK 892

Query: 651 TATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPP 710
             T  G+      S R      + G     G    +P  P       PP GP       P
Sbjct: 893 WGTRGGFNGQMERSPRRTHHWQHNGELAEGGA---EPKDP-------PPPGPHSEDLKVP 942

Query: 711 PPAAPAS--GPPLSATQIKQEPAEEYETPESPVPPARSPSPPP 751
           P     S  G        +   +   +    P P AR+  P P
Sbjct: 943 PGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLP 985



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 60/227 (26%), Positives = 78/227 (34%), Gaps = 44/227 (19%)

Query: 563 PNGPPVSSSSNSSSST-SQGSYPCSHPSPSQGPQGAPYPFPPVPTVT------------- 608
           P+G  +SS   + S   S G+  C    P   P+   + F P+  VT             
Sbjct: 39  PSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPK--VFNFDPLAPVTPGGAGVGPASEED 96

Query: 609 -----------TSSATLSTVIATVASSPAGYKTASP-------PGPPPYGKRAPSPGAYK 650
                       + ATL   + T  S  +  + ASP       PGPP        P    
Sbjct: 97  MTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTP 156

Query: 651 TATPPGYKPGSPPSFRTGTPP--GYRGTSPP--AGPGTFKPGSPTVGPGPLPPAGPSGLP 706
               PG  P  PPS     P   G  G  PP  A P    P   +  P  LP  G +  P
Sbjct: 157 LNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADP---VPSGGSSSPRFLP-RGNAPSP 212

Query: 707 SLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS--PSPPP 751
           + PPPPA   + P  +     +      +    P P A S  PS PP
Sbjct: 213 APPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPP 259



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 26/77 (33%), Positives = 32/77 (41%), Gaps = 11/77 (14%)

Query: 691 TVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPP 750
           TV PGP     PS  P    PP  P +G P S        ++ + T   P         P
Sbjct: 137 TVSPGP-----PSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGP-----GGLFP 186

Query: 751 PKVVD-VPSHASQSARF 766
           P++ D VPS  S S RF
Sbjct: 187 PRLADPVPSGGSSSPRF 203


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  115 bits (289), Expect = 2e-25
 Identities = 171/654 (26%), Positives = 218/654 (33%), Gaps = 135/654 (20%)

Query: 158  PYHPPPLFPPSPQPPDSTPRQ--PEAS-FEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPP 214
            P  PPP   P   PP+ +P    PEAS   P P   P     P     SR  +  P +PP
Sbjct: 439  PLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPAS-PLPEALHLSRPLEESPLSPP 497

Query: 215  PHPQLYPGGTGGVLSGPP-MGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT 273
            P            LS PP   P      S +  P      P   TP+S     +  +PP 
Sbjct: 498  PEE--------SPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF 549

Query: 274  KPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLN----NASASPPGLGAQPLPGHL 329
            +          LP++PPP         L PPP   P++     +  SPP   ++  P   
Sbjct: 550  EESPLSPPPEELPTSPPPE-----ASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFE 604

Query: 330  PSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSS 389
             SP         L P PE+      SP S PP +S    PP   P S     S     S 
Sbjct: 605  ESP---------LSPPPEE------SPLSPPPEASRLSPPPEDSPMSPPPEES---PMSP 646

Query: 390  SSSSSSASPFPASQALPSYPHSFP--PPTSLSVSNQPPKYTQPSLPSQAVWSQGPP---- 443
                S  SP P    L   P   P  PP   S ++ PP+ ++ S P +   +  PP    
Sbjct: 647  PPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSP 706

Query: 444  -PPPPYGRL----LANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQ 498
              PPP   L    L  S   P P  P    +S   P +S      +     + ++     
Sbjct: 707  ASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEG-PHLSP--RPEEPHLSPRPEEPHLSP 763

Query: 499  QQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSY 558
            Q ++ H +  P  P     P E     H  P A  P L       P   HL P   +   
Sbjct: 764  QAEEPHLSPQPEEPCLCAVPEE----PHLSPQAEGPHLSP----QPEELHLSPQTEEPHL 815

Query: 559  SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVI 618
            S   P  P +S     S  + Q   PC  P P +         PP+              
Sbjct: 816  SPV-PEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPL-------------- 860

Query: 619  ATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSP 678
                 SP   K    PG  P                      +P       PPG    SP
Sbjct: 861  -----SPRPEKPPEEPGQCP----------------------APEELPLFPPPGEPSLSP 893

Query: 679  PAG-PGTFKPGSPTVGPGPLP-PAGPSGLPSLP---------PPPAAP----ASGPPLSA 723
              G P   +PG P + P P   P  PSG PSL          PPP +P    A+ P LS 
Sbjct: 894  LLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSP 953

Query: 724  TQIKQEP--------------AEEYETPESPVPPAR--SPSPPPKVVDVPSHAS 761
                + P              A   ETP SP P A    P P P ++  PS  S
Sbjct: 954  LGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGS 1007



 Score =  110 bits (276), Expect = 6e-24
 Identities = 168/649 (25%), Positives = 219/649 (33%), Gaps = 90/649 (13%)

Query: 156  ARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPP 215
            +RP    PL PP    P+ +P  P     P   +  +    P E P S   + P   PP 
Sbjct: 486  SRPLEESPLSPP----PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPE 541

Query: 216  HPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPP-TTPISVSSSGASGAPPTK 274
               L P      LS PP          +   P   +  PPP  +P+S     +  +PP +
Sbjct: 542  ASPLSPPFEESPLSPPP------EELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPE 595

Query: 275  PPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALR---PLNNASASPPGLGAQPLPGHLPS 331
                       P +PPP      +P  PPP A R   P  ++  SPP   +   P    S
Sbjct: 596  ASRLFPPFEESPLSPPPEE----SPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVS 651

Query: 332  PHAMGQGMGGLPPGPEKGPTLAP---SPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSS 388
              +    +  L P PE+ P   P   SP S PP +S    PP   P S     S A+   
Sbjct: 652  RLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPP 711

Query: 389  SSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP------PKYTQPSLPSQAVWSQGP 442
              S  S          LP  P   P      +S +P      P+  +P L  QA   +  
Sbjct: 712  EDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQA--EEPH 769

Query: 443  PPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQ---QQQ 499
              P P    L      P   P + G   +  P     H   Q ++       ++     Q
Sbjct: 770  LSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQP--EELHLSPQTEEPHLSPVPEEPCLSPQ 827

Query: 500  QQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP-GPAHLPPPHSQVSY 558
             ++ H +     P   P P E     H  P    P L      PP  P   P P     +
Sbjct: 828  PEESHLSPQSEEPCLSPRPEES----HLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLF 883

Query: 559  SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQ---GPQGAPYPFPPVPTVTTSSATLS 615
                P G P  S      + S+   P   P P +    P G P   P +         LS
Sbjct: 884  P---PPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLS 940

Query: 616  TVIATVASSPAGYKTASPPG--PPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGY 673
             +I T A+ PA     SP G    P+G +  S      A P    P SP       PP  
Sbjct: 941  PII-TAAAPPA----LSPLGELEYPFGAKGDSDPESPLAAPILETPISP-------PPEA 988

Query: 674  RGTSPPAGPGTFKPGSP--TVGPG------PLPP----------AGPSGLPSLPPPPAAP 715
              T P   P    P SP   VGP       PLPP             +  PS   PPA P
Sbjct: 989  NCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALP 1048

Query: 716  ASGP-PLS----------ATQIKQEPAEEYETPESPV--PPARSPSPPP 751
             S P PLS            ++ +   E+   PE P   P A SP P P
Sbjct: 1049 LSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSP 1097



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 200/803 (24%), Positives = 259/803 (32%), Gaps = 169/803 (21%)

Query: 81   SEETNAPKKTKTEQELPRPQSPSDLD---SLDGRSLNDDGSSDPRDIDQDNRSTSPSIYS 137
            S    A + +   +ELP    P  L     L+   L+      P     ++   SP   S
Sbjct: 459  SPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEES 518

Query: 138  PGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQ-------PEAS-FEPHPS- 188
            P S   +S  S  L    + P    PL PP  + P S P +       PEAS   P P  
Sbjct: 519  PLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEE 578

Query: 189  --VTPTGYHAPMEPP--TSRMF----QAPPGAPPPHPQLYPGGTGGVLSGPP----MGPK 236
              ++P    +PM PP   SR+F    ++P   PP    L P      LS PP    M P 
Sbjct: 579  SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPP 638

Query: 237  GGGAASSVGG--------PNGGKQHPPPT-TPISVSSSGASGAPPTKPPTTPVGGGNLPS 287
               +  S           P   +  PPP  +P+S     +  +PP +         + P+
Sbjct: 639  PEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPT 698

Query: 288  APPPANFPHVTPN----------------LPPPPALRPLNNAS-ASP----PGLGAQPLP 326
            +PPP + P   P                 LP  P L P +     SP    P L  +P  
Sbjct: 699  SPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEE 758

Query: 327  GHLPSPHAMGQGMGGLPPGP--------------EKGPTLAPSPHSL-------PPASSS 365
             HL SP A    +   P  P               +GP L+P P  L        P  S 
Sbjct: 759  PHL-SPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP 817

Query: 366  APAPPMRFPYSSSSSSSAAASS---SSSSSSSSASP-------FPASQALPSYPHSFPPP 415
             P  P   P    S  S  +     S     S  SP        P  +  P  P   P P
Sbjct: 818  VPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAP 877

Query: 416  TSLSVSNQPPKYT-QPSLPSQAVWSQGPPPPPPYGRLLANSNAH----------PGPFPP 464
              L +   P + +  P L   A+   G PP  P    L  S +           P P PP
Sbjct: 878  EELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPP 937

Query: 465  STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSS 524
                  TA  P +                  + +      G+S P  P A P  LE    
Sbjct: 938  PLSPIITAAAPPAL-------------SPLGELEYPFGAKGDSDPESPLAAPI-LET--- 980

Query: 525  HHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGP-------PVSSSSNSSSS 577
                P +  P      P P  P  LPP       S  GP  P       P  S     S 
Sbjct: 981  ----PISPPPEANCTDPEPVPPMILPPSPG----SPVGPASPILMEPLPPQCSPLLQHSL 1032

Query: 578  TSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSAT-----LSTVIATVASSPAGYKTAS 632
              Q S P S  SP   P   P P  P+  V   S       + T   +    PA   +A+
Sbjct: 1033 VPQNSPP-SQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSAT 1091

Query: 633  PPGPPPYGKR---APSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGP--GTFKP 687
             P P P G     APSP                P+        + G      P  G   P
Sbjct: 1092 SPLPSPMGDLSCPAPSPA---------------PAL-----DDFSGLGEDTAPLDGIDAP 1131

Query: 688  GSPTVGPGPLPPAGPSGLPSLP----PPPAAPASG----PPLSATQIKQEPAEEYETPES 739
            GS    PG  P +  S L   P    P   AP +     P    T  +  P EE E P +
Sbjct: 1132 GSQPE-PGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRA 1190

Query: 740  PVPPARSPSPPPKVVDVPSHASQ 762
            PV P         +V+  S+ SQ
Sbjct: 1191 PVAPTPPTLIKSDIVNEISNLSQ 1213



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 154/603 (25%), Positives = 193/603 (32%), Gaps = 87/603 (14%)

Query: 154  GPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAP 213
            G   P   P +F  SP  P       +   +P     P G     + P     + PP  P
Sbjct: 2114 GSPPPAAAPTIFIGSPTTPAGLSTSADGFLKP-----PAGSVPGPDSPGELFLKLPPQVP 2168

Query: 214  PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT 273
               P   P G        P  P           P G    PP     S   +G  G   T
Sbjct: 2169 AQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHT 2228

Query: 274  KPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPH 333
             PP TP    + PS P P   P   P+L         N A    PG+G       L SP 
Sbjct: 2229 TPPGTP---RHQPSTPDPFLKPR-CPSLD--------NLAVPESPGVGGGKASEPLLSP- 2275

Query: 334  AMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSS 393
                     PP  E    L      L  +S S   P + F  S SS +        +   
Sbjct: 2276 ---------PPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDV 2326

Query: 394  SSASPFP-ASQALPSYP----HSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPY 448
              A   P ASQ  P  P        PP + +++  PP +     P         PP  P 
Sbjct: 2327 FKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTP- 2385

Query: 449  GRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSG 508
                      P P PP +     A PP S       +     Q Q   Q           
Sbjct: 2386 ---------RPQPPPPES---CCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPR----- 2428

Query: 509  PPPPGAF-PHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPP 567
            P    AF P P+         PY+  PS    R  P  P H PP           P  P 
Sbjct: 2429 PLSAEAFCPSPVT-PRFQSPDPYSRPPSRPQSRD-PFAPLHKPP----------RPQPPE 2476

Query: 568  VSSSSNSSSSTS--QGSYPCSHPSPSQG------PQGAPYPFPPVPTVTTSSATLSTVIA 619
            V+  + S + TS   G +P + P+   G      P G P  F   P       T S +  
Sbjct: 2477 VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRF 2536

Query: 620  TVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPG-YRGTSP 678
            T   +  G  +  PP P P     P P    +   PG   G P S       G +  +  
Sbjct: 2537 TFPQA-VGEPSLKPPVPQP---GLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGS 2592

Query: 679  PAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLS--ATQIK--QEPAEEY 734
            P GP +   G  + G  PL P      PS+ PPPA   S P LS  A+Q      P E+ 
Sbjct: 2593 PLGPSSGSTGE-SYGLSPLRP------PSVLPPPAPDGSLPYLSHGASQRSGITSPVEKR 2645

Query: 735  ETP 737
            E P
Sbjct: 2646 EDP 2648



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 165/688 (23%), Positives = 241/688 (35%), Gaps = 147/688 (21%)

Query: 288  APPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPE 347
            +PPPA  P +    P  PA       S S  G   +P  G +P P + G+    LPP   
Sbjct: 2115 SPPPAAAPTIFIGSPTTPA-----GLSTSADGF-LKPPAGSVPGPDSPGELFLKLPP--- 2165

Query: 348  KGPTLAPS--PHSLPPASSSAP----APPMRFPYSSSSSSSAAASSSSSSSSSSASPFPA 401
            + P   PS  P  L PA    P    APP   PY S + + A      +SS   A     
Sbjct: 2166 QVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQ--- 2222

Query: 402  SQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPP-------------PPPY 448
                P   H+ PP T     + P  + +P  PS    +    P             PPP+
Sbjct: 2223 ----PGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPF 2278

Query: 449  GRL----------LANSNAHPGP------FPPSTGAQ----STAHPPVSTHHHHHQQQQQ 488
            G            L  S+   GP        PS+G          P V       +  Q 
Sbjct: 2279 GESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQV 2338

Query: 489  QQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAH 548
            + Q      + Q+     +  P P + P     GS  +  PYA  P     +P PP    
Sbjct: 2339 EPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGS--YTDPYAQPPLTPRPQPPPPESCC 2396

Query: 549  LPPPHSQVSYSQAGPNGPPVSSSSNSSSSTS-----------------QGSYPCSHPSPS 591
              PP S  S   +     P S SS+ S  T                  Q   P S P PS
Sbjct: 2397 ALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRP-PS 2455

Query: 592  QGPQGAPY------PFPPVPTVTTSSATLSTVI-------ATVASSPAGYKTAS-PPGPP 637
            +     P+      P P  P V   + +L+          A + + PAG   A  P G P
Sbjct: 2456 RPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQP 2515

Query: 638  PYGKRAPSPGAYKTATPP---------GYKPGSPPSFRTGTPPGYRGTSPPAGPGTF--K 686
            P   R+P  GA+     P         G     PP  + G PP + G +   GPG    K
Sbjct: 2516 PNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPH-GINSHFGPGPTLGK 2574

Query: 687  PGSP--TVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPA 744
            P S   TV  G   P+G       P  P++ ++G     + ++         P S +PP 
Sbjct: 2575 PQSTNYTVATGNFHPSGS------PLGPSSGSTGESYGLSPLR---------PPSVLPP- 2618

Query: 745  RSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVR 804
              P+P   +  +   ASQ +     +++      R D       G+ +    A       
Sbjct: 2619 --PAPDGSLPYLSHGASQRSGITSPVEK------RED------PGTGMGSSLATAELPGT 2664

Query: 805  REAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFE 864
            ++       + E E++R+R++ RE    ++++R+    ++  A     ++GP        
Sbjct: 2665 QDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGP-------- 2716

Query: 865  PGSAVATVPPYLGPDTPALRTLSEYARP 892
            PGS  A       P +PA   LS    P
Sbjct: 2717 PGSWGAE------PSSPAFEQLSRGQTP 2738



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 138/531 (25%), Positives = 172/531 (32%), Gaps = 95/531 (17%)

Query: 510  PPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPP-GPAHLPPPHSQVSYSQAGPNGPPV 568
            PPP   P      + H + P   SP    L P P   P   PP  S  S  +  P  PP 
Sbjct: 469  PPPEELPASPLPEALHLSRPLEESP----LSPPPEESPLSPPPESSPFSPLEESPLSPPE 524

Query: 569  SSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGY 628
             S  + +  T     P S P P   P   P+   P+        T     A+  S P   
Sbjct: 525  ESPPSPALET-----PLS-PPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEE 578

Query: 629  KTASPP------GPPPYGKRAPSPGAYKTATPPGYK-PGSPP--SFRTGTPPGYRGTSPP 679
               SPP       PPP   R   P      +PP  + P SPP  + R   PP     SPP
Sbjct: 579  SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPP 638

Query: 680  AGPGTFKPGSPTVGPGPLPPAG-----PSGLPSLPPPPAAPASGPPLSATQIKQEPAEEY 734
                   P        PLP        P   P  PPP  +P S PP  A+++   P +  
Sbjct: 639  PEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPP-EASRLSPPPED-- 695

Query: 735  ETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAK 794
             +P SP P     SPPP+                             L  +PLE S L  
Sbjct: 696  -SPTSPPPEDSPASPPPE---------------------------DSLMSLPLEESPLLP 727

Query: 795  KRADLVEKVRREAEQRAREEKEREREREREKERE-REKERELERSVKLAQEGRAPVECPS 853
                    +  E +   R E      R  E     R +E  L    +       P E P 
Sbjct: 728  --------LPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE-PC 778

Query: 854  LGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDP 913
            L  VP  P   P +      P+L P    L    +   PH +SP        VP    +P
Sbjct: 779  LCAVPEEPHLSPQAE----GPHLSPQPEELHLSPQTEEPH-LSP--------VP---EEP 822

Query: 914  GLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPR 973
             L     P    S  + +  E     R     L P  E  P    P      PG  P P 
Sbjct: 823  CLS----PQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPE 878

Query: 974  HGGLALQPGPPGLHPF--------PFHPSLGPLERE-RLALAAGPALRPDM 1015
               L   PG P L P         P  P L PL  E  L+ +  P+L P +
Sbjct: 879  ELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQL 929



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 282/1222 (23%), Positives = 390/1222 (31%), Gaps = 235/1222 (19%)

Query: 71   GRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130
            G S +  E + EE  A   +     L    SPS    L G  L    + D        R+
Sbjct: 2279 GESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELK---TPDVFKAPLTPRA 2335

Query: 131  TSPSIYSPGSVENDSDSSSGLSQGPARPYHP--------------PPLFP-PSPQPPDST 175
            +     SPG      +     +  P+ P HP              PPL P P P PP+S 
Sbjct: 2336 SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESC 2395

Query: 176  PRQPEASFEPHP----SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGP 231
               P  S    P      +P    +   P T R   A    P P    +   +    S P
Sbjct: 2396 CALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQ--SPDPYSRP 2453

Query: 232  PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPP- 290
            P  P+          P      PP   P  V+    S A       T +G G  P+A P 
Sbjct: 2454 PSRPQSRD-------PFAPLHKPPRPQPPEVAFKAGSLAH------TSLGAGGFPAALPA 2500

Query: 291  -PANFPHV-TPNLPPPPALRPLNNASASPPGLGA---QPLPGHLPSPHAMGQGMGGLPPG 345
             PA   H   P+  PP  +R         PG GA    P P     P A+G+     PP 
Sbjct: 2501 GPAGELHAKVPSGQPPNFVRS--------PGTGAFVGTPSPMRFTFPQAVGEP-SLKPPV 2551

Query: 346  PEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSS----------SSSSAAASSSSSSSSSS 395
            P+ G    P PH +   S   P P +  P S++          S S    SS S+  S  
Sbjct: 2552 PQPG---LPPPHGIN--SHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYG 2606

Query: 396  ASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANS 455
             SP      LP      PP    S+       +Q S  +  V  +   P    G  LA +
Sbjct: 2607 LSPLRPPSVLP------PPAPDGSLPYLSHGASQRSGITSPV-EKREDPGTGMGSSLATA 2659

Query: 456  NAHPGPFPPSTGAQSTAHPPVSTHHHHHQ---QQQQQQQQQQQQQQQQQQHHGNSGPPPP 512
                   P  +G   T            +   +QQ Q+   +Q+++      G  GPP  
Sbjct: 2660 ELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGS 2719

Query: 513  -GAFPH-PLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP--PPHSQVSYSQAGPNGPPV 568
             GA P  P     S    P+A +    SL   PP     P   P S  S  +     PP 
Sbjct: 2720 WGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPA 2779

Query: 569  SSSS----------NSSSSTSQGSYPCSHPSPSQGPQ-----------------GAPYPF 601
            + SS           S +   +  YP S P   Q  Q                  A +P 
Sbjct: 2780 TPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPS 2839

Query: 602  PPVPTVTTSSATLSTVIATVASSPAGYKTASP-PGPPPYGKRAPSP----------GAYK 650
             P P +   +         + S  AG  T  P PG P  G   P+           G   
Sbjct: 2840 TPGPELGRQA---------LGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQKGLGP 2890

Query: 651  TATP-PGYKPGSPPSFRTGT-------PPGYRGTS----PPAGPGTFKPGSPTVGPG--P 696
              TP PG  P   P F   +       P G RG +    PP  P    P +P +     P
Sbjct: 2891 GGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSA--PPAPELNNSLHP 2948

Query: 697  LP----PAGPSGLPSLPPPPAAPASGPPLS-ATQIKQEPAEEYETPESPVPPARSPSPPP 751
             P    P  P+GL  +  PP++   G P   A +  + P E+ E  +             
Sbjct: 2949 TPHTKGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPCEDPELDD------------- 2995

Query: 752  KVVDVPSH-ASQSARFNKHLDRGFNSCARSDLYFVPLEGSK---------LAKKRADLVE 801
               D  +H A +      HL  G +  A+ D     LE  +         L     DL+ 
Sbjct: 2996 ---DFDAHKALEDDEELAHLGLGVD-VAKGDDELGTLENLETNDPHLDDLLNGDEFDLLA 3051

Query: 802  KVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRP 861
                E +   +++   E  R  E   E+ +   L R V+               P P  P
Sbjct: 3052 YTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVE---------------PGPLGP 3096

Query: 862  PFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHP--FYVPLGAVDPGLLGYN 919
               P       PP      P L ++    +P V   G    P  F +    V+P      
Sbjct: 3097 EERP-------PPAADASEPRLASVLPEVKPKVEEGGRHPSPCQFTIATPKVEP------ 3143

Query: 920  VPALYSSDPAAREREREARERDLRDRLKP----GFEVKPSELEPLHGVPGPGLDPFPRHG 975
             PA  S     +  +     RD R    P    G   + +      G P   L P P  G
Sbjct: 3144 APAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPLSG 3203

Query: 976  GLALQPGPPGLHPFPFHPSLGPLERERLALAAGPAL---RPDMSYAERLAAERQ-HAERV 1031
                 PG   L           LE   L L  GPA      D   +  +A+E     E +
Sbjct: 3204 -----PGGSSL------LEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDL 3252

Query: 1032 AALGNDPLARLQMLN--VTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHL 1089
                   L + Q L+  + P   Q      H  L       A S   H    P  +GS  
Sbjct: 3253 LEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLP-HEGSSPSLAGSQ- 3310

Query: 1090 TRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAE 1149
             ++         P LP PL   +   H L     + L  S++   +  H L   H   A 
Sbjct: 3311 QQLSLGLAGARQPGLPQPLMPTQPPAHAL----QQRLAPSMAMVSNQGHMLSGQHGGQAG 3366

Query: 1150 LQRLALEQQQWLHAHHPLHSVP 1171
            L  +  +  Q + +  P+ ++P
Sbjct: 3367 L--VPQQSSQPVLSQKPMGTMP 3386



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 183/792 (23%), Positives = 244/792 (30%), Gaps = 149/792 (18%)

Query: 236  KGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFP 295
            +GG    SV      +QH P  +  S    G +  P  +P    V     P         
Sbjct: 353  QGGQTIRSVA-----EQHTPVCSRFSPPEPGDT--PTDEPDALYVACQGQPKGG------ 399

Query: 296  HVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAP- 354
            HVT   P  P   PL    A P G     L   L +P  + + M  LPP PE+ P   P 
Sbjct: 400  HVTSMQPKEPG--PLQ-CEAKPLGKAGVQLEPQLEAP--LNEEMPLLPP-PEESPLSPPP 453

Query: 355  --SPHSLPPASSSAPAPPMRFPYS------------SSSSSSAAASSSSSSSSSSASPF- 399
              SP S PP +S    PP   P S              S  S     S  S    +SPF 
Sbjct: 454  EESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFS 513

Query: 400  PASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPP-------PPPPYGRLL 452
            P  ++  S P   PP  +L     PP    P  P        PP       PPP   RL 
Sbjct: 514  PLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLS 573

Query: 453  ANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPP 512
                  P   PP     S   PP ++      ++       ++             PPP 
Sbjct: 574  PPPEESPMSPPPEESPMSP--PPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPE 631

Query: 513  GA--FPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
             +   P P E        P +  P +  L P P      PPP       +  P  PP   
Sbjct: 632  DSPMSPPPEES-------PMSPPPEVSRLSPLPVVSRLSPPP-------EESPLSPPPEE 677

Query: 571  SSNSSSSTSQGSYPCSHPSP-SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK 629
            S  S    +    P    SP S  P+ +P   PP  ++ +     S ++           
Sbjct: 678  SPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPL--------- 728

Query: 630  TASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS 689
                P  P    R+  P        P   P              R   P   P   +   
Sbjct: 729  ----PEEPQLCPRSEGPHLSPRPEEPHLSP--------------RPEEPHLSP---QAEE 767

Query: 690  PTVGPGPLPPAGPSGLPSLPPPP--AAPASGPPLSATQIKQEPAEEYETPE-SPVPPARS 746
            P + P P  P     L ++P  P  +  A GP LS    +   + + E P  SPVP    
Sbjct: 768  PHLSPQPEEPC----LCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPC 823

Query: 747  PSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRRE 806
             SP P+     SH S  +       R   S    +L   PL                   
Sbjct: 824  LSPQPE----ESHLSPQSEEPCLSPRPEESHLSPELEKPPLS------------------ 861

Query: 807  AEQRAREEKEREREREREKERER---EKERELERSVKLAQEGRAPVECPSLGPVPHRPPF 863
                 R EK  E   +     E        E   S  L +   +    P L P+P   P 
Sbjct: 862  ----PRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPL 917

Query: 864  EPGSAVATVPPYLGPD--TPALRTLSEYARPHVMSP-GNRNHPFYVPLGAVDPGLLGYNV 920
             P    +  P  + PD   P L  +   A P  +SP G   +PF         G  G + 
Sbjct: 918  SPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPF---------GAKGDSD 968

Query: 921  PALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQ 980
            P    + P          E +  D         P  + P+   P PG  P      + ++
Sbjct: 969  PESPLAAPILETPISPPPEANCTD---------PEPVPPMILPPSPG-SPVGPASPILME 1018

Query: 981  PGPPGLHPFPFH 992
            P PP   P   H
Sbjct: 1019 PLPPQCSPLLQH 1030



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 129/514 (25%), Positives = 164/514 (31%), Gaps = 62/514 (12%)

Query: 517  HPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSS 576
            H  +GG +  +     +P      P  PG      P +     Q  P G  V+S      
Sbjct: 350  HKAQGGQTIRSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEP 409

Query: 577  STSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPP-- 634
               Q     + P    G Q  P    P+         L     +  S P      SPP  
Sbjct: 410  GPLQCE---AKPLGKAGVQLEPQLEAPL---NEEMPLLPPPEESPLSPPPEESPTSPPPE 463

Query: 635  ----GPPPYGKRA-PSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKP-- 687
                 PPP    A P P A   + P    P SPP       P     SPP     F P  
Sbjct: 464  ASRLSPPPEELPASPLPEALHLSRPLEESPLSPP-------PEESPLSPPPESSPFSPLE 516

Query: 688  GSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP 747
             SP   P   PP+     P  PPP A+P S PP   + +   P E    P SP P A   
Sbjct: 517  ESPLSPPEESPPSPALETPLSPPPEASPLS-PPFEESPLSPPPEE---LPTSPPPEASRL 572

Query: 748  SPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREA 807
            SPPP+   +     +S           +    +   F P E S L+    +       EA
Sbjct: 573  SPPPEESPMSPPPEESP---------MSPPPEASRLFPPFEESPLSPPPEESPLSPPPEA 623

Query: 808  EQRAREEKEREREREREKEREREKERELERSVKLAQEGRA--PVECPSLGPVPHRPPFEP 865
             + +   ++       E E       E+ R   L    R   P E   L P P   P  P
Sbjct: 624  SRLSPPPEDSPMSPPPE-ESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSP 682

Query: 866  GSAVATV--PPYLGPDTPALRTLSEYARPH--VMSPGNRNHPFYVPLGAVDPGLLGYNVP 921
                + +  PP   P +P          P   +MS      P  +PL   +P L     P
Sbjct: 683  PPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPL-LPLPE-EPQLC----P 736

Query: 922  ALYSSDPAAREREREARERDLRDRLKPGFE---VKPSELEP-LHGVP----------GPG 967
                   + R  E     R     L P  E   + P   EP L  VP          GP 
Sbjct: 737  RSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPH 796

Query: 968  LDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERE 1001
            L P P    L+ Q   P L P P  P L P   E
Sbjct: 797  LSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEE 830



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 116/447 (25%), Positives = 141/447 (31%), Gaps = 122/447 (27%)

Query: 331  SPHAMGQGMGGLPPGPE-KGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSS 389
            +P +M    G + P        L   P   P  SS    PP+R P       S   ++  
Sbjct: 4054 TPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGG 4113

Query: 390  SSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGP------P 443
             S     S   +S    S PH    P S+S+ +QP   TQ  L  Q    + P      P
Sbjct: 4114 GSHGQLGSG--SSSEASSVPHLLAQP-SVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGP 4170

Query: 444  PPPPYGRLLANSNAHPGP-FPPSTG---AQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQ 499
             PP  G +L +    PG    P+ G   AQ       +    H   QQQQQ Q    Q+Q
Sbjct: 4171 QPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQ 4230

Query: 500  QQQHHGNSGPPP---PGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556
             QQ       PP   PG    PL+G            P LG      PGP          
Sbjct: 4231 LQQSQAVRQTPPYQEPGTQTSPLQG-------LLGCQPQLGGF----PGP---------- 4269

Query: 557  SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLST 616
               Q GP                 G  P       QGP   P P    P   ++   L  
Sbjct: 4270 ---QTGP-----------LQELGAGPRP-------QGPPRLPAP----PGALSTGPVLGP 4304

Query: 617  VIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGT 676
            V                P PPP   + P             +P   PS  +  P      
Sbjct: 4305 V---------------HPTPPPSSPQEPK------------RPSQLPSPSSQLPT--EAQ 4335

Query: 677  SPPAGPGTFKPGSPTVGPGP--LPPA-------------GPSGLP------------SLP 709
             PP  PGT KP  PT+ P P  + PA             GP   P            SL 
Sbjct: 4336 LPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLV 4395

Query: 710  PPPAAPASG---PPLSATQIKQEPAEE 733
            P      +G   P  S   IKQEP EE
Sbjct: 4396 PGHLDQVNGQVVPEASQLSIKQEPREE 4422



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 105/397 (26%), Positives = 124/397 (31%), Gaps = 146/397 (36%)

Query: 484  QQQQQQQQQQQQQQ-------------QQQQQHHGNSGP----------PPPGAFPHPL- 519
            QQQQQ QQQQQQQQ             QQQQQ     GP            PGA    L 
Sbjct: 3961 QQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLL 4020

Query: 520  ------------------EGGSSHHAHPYAMS--------------PSLGS------LRP 541
                              EG S+H   P A+               PSL        ++P
Sbjct: 4021 LTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQP 4080

Query: 542  YP---PGPAHLPPP-------HSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPS 591
             P   P    L PP         QVS       G      S SSS  S   +  + PS S
Sbjct: 4081 QPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS 4140

Query: 592  QGPQGAPY---------------------PFPP-----------------VPTVTTSSAT 613
             G Q                         P PP                 +PTV    A 
Sbjct: 4141 LGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQ 4200

Query: 614  LSTVIATVASSPAGYKTASPPGPPPYG----KRAPSPGAYKTATPPGYKPGSPPSFRTGT 669
            L  V+A    +P   +  SP           +R          TPP  +PG+    +T  
Sbjct: 4201 LQGVLA---KNPQ-LRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGT----QTSP 4252

Query: 670  PPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAG----PSGLPSLPPPPAAPASGPPLSATQ 725
              G  G  P  G      G P    GPL   G    P G P LP PP A ++GP L    
Sbjct: 4253 LQGLLGCQPQLG------GFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLG--- 4303

Query: 726  IKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQ 762
                       P  P PP  SP  P +   +PS +SQ
Sbjct: 4304 -----------PVHPTPPPSSPQEPKRPSQLPSPSSQ 4329



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 218/993 (21%), Positives = 321/993 (32%), Gaps = 204/993 (20%)

Query: 246  GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPP 305
            GP G ++ PPP    S     AS  P  KP      GG  PS   P  F   TP + P P
Sbjct: 3092 GPLGPEERPPPAADASEPRL-ASVLPEVKPKVEE--GGRHPS---PCQFTIATPKVEPAP 3145

Query: 306  ALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365
            A   L        GLG +P           GQ M G                       S
Sbjct: 3146 AANSL--------GLGLKP-----------GQSMMG-----------------------S 3163

Query: 366  APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPP 425
                    P+SSS  ++  AS  ++         P +  L   P S P  +SL    +  
Sbjct: 3164 RDTRMGTGPFSSSGHTAEKASFGATGG-------PPAHLLTPSPLSGPGGSSLLEKFE-- 3214

Query: 426  KYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQ 485
                  L S A+   G P         A S         S  A     P +      H++
Sbjct: 3215 ------LESGALTLPGGP---------AASGDELDKMESSLVASEL--PLLIEDLLEHEK 3257

Query: 486  QQQQQQQQ--------QQQQQQQQQHHGNSGPPPPGAFPHPLEGGS-SHHAHPYAMSPSL 536
            ++ Q++QQ        QQQQQQQQQH   S P P  A   P EG S S       +S  L
Sbjct: 3258 KELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGL 3317

Query: 537  -GSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGS-----YPCSHPSP 590
             G+ +P  P P     P +     +  P+   VS+  +  S    G         S P  
Sbjct: 3318 AGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQSSQPVL 3377

Query: 591  SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGY-KTASPPGPPPYGKRAPSPGAY 649
            SQ P G     PP   +      +   +A          K A+     P  K        
Sbjct: 3378 SQKPMGT---MPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKA------- 3427

Query: 650  KTATPPGYKPGSPPSFRTGTPPGYR-------GTSPPAGPGTFKPGSPTVGPGPLPPAGP 702
            K     G K         G  PG               GP +        G G    AG 
Sbjct: 3428 KMVALKGIKKVMAQG-SIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQERSAG- 3485

Query: 703  SGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVD--VPSHA 760
                     P+ P   PP  A  +  E A++ +  E      +      KV++  +  H 
Sbjct: 3486 --------DPSQPRPNPPTFAQGVINE-ADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHR 3536

Query: 761  SQ------SARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREE 814
                      R  K   R F       L  V  + SK+ +K+ D V K ++E      E 
Sbjct: 3537 KSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKI-QKQLDQVRKQQKEHTNLMAEY 3595

Query: 815  KEREREREREKEREREKERELERSVKLAQEGRAPVECP-------SLGPVPHRPPFEPGS 867
            + +++++++++++++++   +  ++  +Q  R   + P        L P P  PP     
Sbjct: 3596 RNKQQQQQQQQQQQQQQHSAV-LALSPSQSPRLLTKLPGQLLPGHGLQP-PQGPPGGQAG 3653

Query: 868  AVATVPPYLG----PDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPAL 923
             +   P  +     P  P L T     +    S G  +     P G   PG L     AL
Sbjct: 3654 GLRLTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGS--LAGPSGGFFPGNL-----AL 3706

Query: 924  YSSDPAAR---EREREARER--DLRDRLKPGFEVKPSELEPLHGV-------PGPGLDPF 971
             S  P +R   ER+ + +++   L  +L+   + +  +   L  V        GPG+   
Sbjct: 3707 RSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQT- 3765

Query: 972  PRHGGLALQPGPPGLHPFPFHPS-----------------LGPLERERLALAAGPALRPD 1014
                  AL P P GL P   H                   LGP +   L      AL P 
Sbjct: 3766 ----NQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQ 3821

Query: 1015 MSYAE------RLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDA 1068
              + +      R+ +  Q A++   L    L   Q       H Q   +    HL Q   
Sbjct: 3822 GPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLM 3881

Query: 1069 IHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVL--RHQLFAAPYRDL 1126
             H+    +                  P G+L        L + + L  + Q      + L
Sbjct: 3882 SHSGQPKLS---------------AQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQL 3926

Query: 1127 PASLSAPMSAAHQLQAMHAQSAELQRLALEQQQ 1159
                        QLQ    Q  + Q+  L+QQQ
Sbjct: 3927 QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQ 3959



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 189/872 (21%), Positives = 265/872 (30%), Gaps = 176/872 (20%)

Query: 10   MSMRSGRKKEAPGPREELRSRGRASPG-GVSTSSSDGKAEKSRQTAKKARVEEASTPKVN 68
            M   +G +   PGP   +   G+  PG G+  +    +A+     AK  ++   S  +  
Sbjct: 4164 MQNNTGPQPPKPGP---VLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQ-- 4218

Query: 69   KQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDN 128
            +Q     + + + +++ A ++T   QE     SP  L  L G      G   P+      
Sbjct: 4219 QQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSP--LQGLLGCQPQLGGFPGPQTGPLQE 4276

Query: 129  RSTSPSIYSPGSVENDSDS-SSGLSQGPARPYHPPPLFPPSPQPPDSTPRQP-----EAS 182
                P    P  +     + S+G   GP  P  PPP  P  P+ P   P        EA 
Sbjct: 4277 LGAGPRPQGPPRLPAPPGALSTGPVLGPVHPT-PPPSSPQEPKRPSQLPSPSSQLPTEAQ 4335

Query: 183  FEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTG--------GVLSGPPMG 234
              P    TP      +EPP  R+    P A      L+  G G             P   
Sbjct: 4336 LPPTHPGTPKPQGPTLEPPPGRV---SPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQS 4392

Query: 235  PKGGGAASSVGG---PNGGK---QHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSA 288
                G    V G   P   +   +  P   P ++ +         +P   P    +L  A
Sbjct: 4393 SLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLA 4452

Query: 289  PPPANFPHVTPNLPPPPALRPLN---NASASPPGLGAQPLPGHLPSPHA-MGQGMGGLPP 344
             P +   H    L     LR  N   +      GL A+ + GH+ S  A + Q + G P 
Sbjct: 4453 GPRSEAGH----LLLQKLLRAKNVQLSTGRGSEGLRAE-INGHIDSKLAGLEQKLQGTPS 4507

Query: 345  GPEKGPT---LAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPA 401
              E       L P P  +  AS    +   +           A+ +         S  P 
Sbjct: 4508 NKEDAAARKPLTPKPKRVQKASDRLVSSRKKL---RKEDGVRASEALLKQLKQELSLLPL 4564

Query: 402  SQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGP 461
            ++   +   S   P             + +  S A+    P  P  Y +LL  +N    P
Sbjct: 4565 TEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGAL----PTGPDYYSQLLTKNNLSNPP 4620

Query: 462  FPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEG 521
             PPS+   +   PP S                       QQ   N   P      HP + 
Sbjct: 4621 TPPSSLPPT---PPPSV----------------------QQKMVNGVTPSEELGEHPKDA 4655

Query: 522  GSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQG 581
             S+  +       S   ++      A   PPH+Q            V   S+  S +   
Sbjct: 4656 ASARDSERALRDTS--EVKSLDLLAALPTPPHNQTE---------DVRMESDEDSDSPDS 4704

Query: 582  SYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA---------SSPAGYKTAS 632
              P S P    G +   +P             LS VI  +          + P G     
Sbjct: 4705 IVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLE 4764

Query: 633  PPGPPPY-----GKRAP-------SPGAYKTAT--------------PPGYKPGSPPS-F 665
             PG  P      GK +        S  A K                 P  Y+   P S  
Sbjct: 4765 VPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPA 4824

Query: 666  RTGTPP-------------GYRGTSPPAGPGTFK------PG------------SPTVGP 694
            R GT P             G  G SP  GP   K      PG                 P
Sbjct: 4825 RAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESP 4884

Query: 695  GPLPP------------------AGPSGLPSLPPPPAA--PASGPPLSATQIKQEPAEEY 734
             P PP                  A P   PS PP P A  PAS P     ++  EP  E 
Sbjct: 4885 APEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEP 4944

Query: 735  ETPESPVPPARSP-SPPPKVVDVPSHASQSAR 765
              P SP+P A SP S  PK    P    + +R
Sbjct: 4945 PVP-SPLPLASSPESARPKPRARPPEEGEDSR 4975



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 77/333 (23%), Positives = 97/333 (29%), Gaps = 59/333 (17%)

Query: 178  QPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKG 237
            QP  S    P         P +P   R  Q   G  PP P       G VL     G  G
Sbjct: 4136 QPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKP-------GPVLQS-GQGLPG 4187

Query: 238  GGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHV 297
             G   +VG              +     G     P     +P     L +          
Sbjct: 4188 VGIMPTVG-------------QLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQS 4234

Query: 298  TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPH 357
                  PP   P    S     LG QP              +GG  PGP+ GP       
Sbjct: 4235 QAVRQTPPYQEPGTQTSPLQGLLGCQP-------------QLGGF-PGPQTGPLQELGAG 4280

Query: 358  SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
              P      PAPP             A S+         +P P+S   P  P   P P+S
Sbjct: 4281 PRPQGPPRLPAPP------------GALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSS 4328

Query: 418  LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRL------LANS--NAHPGPFPPSTGAQ 469
               +      T P  P      QGP   PP GR+      LA++  +   GP+ P     
Sbjct: 4329 QLPTEAQLPPTHPGTPK----PQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLA 4384

Query: 470  STAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQ 502
             T  P  S+    H  Q   Q   +  Q   +Q
Sbjct: 4385 ETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQ 4417



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 73/340 (21%), Positives = 111/340 (32%), Gaps = 56/340 (16%)

Query: 31   GRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKT 90
            G   PG    S ++ + ++ RQ  ++  + +       +Q   +E + + +     P   
Sbjct: 2663 GTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQ--EKETAAAAAGAVGPPGSW 2720

Query: 91   KTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRD-IDQDNRSTSPSIYSPGSVENDSDSSS 149
              E     P SP+  + L        G+ D    +       S  I  PGS  +D   S 
Sbjct: 2721 GAE-----PSSPA-FEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLS- 2773

Query: 150  GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP 209
                       PPP  P +P   D   RQ     +      P     P++    +++Q  
Sbjct: 2774 ----------RPPP--PATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQ 2821

Query: 210  PGAPPPHPQL-----YPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTP---IS 261
                    +      +P   G  L    +G    G ++ + GP  G+  P P  P   I 
Sbjct: 2822 QATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGP--GEPVPGPAGPAQFIE 2879

Query: 262  VSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLG 321
            +  +   G  P        GG   P   PP   P   P    P  L P         GL 
Sbjct: 2880 LRHNVQKGLGP--------GGTPFPGQGPPQR-PRFYPVSEDPHRLAP-----EGLRGLA 2925

Query: 322  AQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPP 361
               LP   PS           PP PE   +L P+PH+  P
Sbjct: 2926 VSGLPPQKPSA----------PPAPELNNSLHPTPHTKGP 2955



 Score = 37.7 bits (86), Expect = 0.066
 Identities = 43/149 (28%), Positives = 52/149 (34%), Gaps = 23/149 (15%)

Query: 861  PPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVP------------- 907
            PP  P    +T  P+L P  P+L  L+    P V   G  + P   P             
Sbjct: 2230 PPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGV-GGGKASEPLLSPPPFGESRKALEVK 2288

Query: 908  ---LGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVP 964
               LGA  P    Y  P L   D  +        E    D  K     + S++EP    P
Sbjct: 2289 KEELGASSP---SYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQS--P 2343

Query: 965  GPGLDPFPRHGGLALQPGPPGLHPFPFHP 993
            G GL P       AL P PP  HP  F P
Sbjct: 2344 GLGLRPQEPPPAQALAPSPPS-HPDIFRP 2371



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 65/263 (24%), Positives = 87/263 (33%), Gaps = 42/263 (15%)

Query: 484  QQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYP 543
            QQQQQQ QQQQQQ QQQQQ                L   S     P        +L P  
Sbjct: 3942 QQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGM 4001

Query: 544  PGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGP---QGAPYP 600
            P     P  H    +S  G  GP +  +    ++      P      ++GP   QG P  
Sbjct: 4002 PAK---PLQH----FSSPGALGPTLLLTGKEQNTVD----PAVSSEATEGPSTHQGGPL- 4049

Query: 601  FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATP---PGY 657
                  + T+  +++T    V  S +G        P P     P P + +   P   PG 
Sbjct: 4050 -----AIGTTPESMATEPGEVKPSLSGDSQLLLVQPQP----QPQPSSLQLQPPLRLPGQ 4100

Query: 658  KPGSPPSFRTGTPPGY----RGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGL-----PSL 708
            +        T     +     G+S  A         P+V  G  P +    L     P L
Sbjct: 4101 QQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPML 4160

Query: 709  PPP------PAAPASGPPLSATQ 725
              P      P  P  GP L + Q
Sbjct: 4161 ERPMQNNTGPQPPKPGPVLQSGQ 4183



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 44/174 (25%), Positives = 60/174 (34%), Gaps = 32/174 (18%)

Query: 316  SPPGLGAQPLPGHLPSPHAMGQGMGGLPP--GPE---------KGPTLAPSPH--SLPPA 362
            SP   G +P  G    P    +G+ G  P  GP+          G TL       SL   
Sbjct: 4822 SPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQ 4881

Query: 363  SSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN 422
             S AP PP +  Y+ + S+      S+                P      PPP+ L+ S 
Sbjct: 4882 ESPAPEPPTQHSYTYNVSNLDVRQLSA----------------PPPEEPSPPPSPLAPSP 4925

Query: 423  -QPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP 475
              PP      LP++ +     P P P      ++   P   PP  G  S   PP
Sbjct: 4926 ASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDS--RPP 4977



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 32/95 (33%), Positives = 33/95 (34%), Gaps = 16/95 (16%)

Query: 671  PGYRGTSPPAGPGTFKPGSPTVGPG--------PLPPAGPSGLPSLPP------PPAAPA 716
            PG  G+ PPA   T   GSPT   G          PPAG    P  P       PP  PA
Sbjct: 2110 PGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPA 2169

Query: 717  SGPPLSATQIKQEPAEEYETPESPVPPARSPSPPP 751
              P  S       PA   E      PP   P P P
Sbjct: 2170 QVP--SQDPFGLAPAYPLEPRFPTAPPTYPPYPSP 2202



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 10/70 (14%)

Query: 255  PPTTPISVSSSGASGAPPTKP----PTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPL 310
            PP +P++ S +    +PPT+P    PT P+    +PS  P A+ P      P P A  P 
Sbjct: 4916 PPPSPLAPSPA----SPPTEPLVELPTEPLAEPPVPSPLPLASSPESA--RPKPRARPPE 4969

Query: 311  NNASASPPGL 320
                + PP L
Sbjct: 4970 EGEDSRPPRL 4979



 Score = 30.8 bits (68), Expect = 8.0
 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 1/64 (1%)

Query: 677  SPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYET 736
            SPP  P    P SP   P    P  P   P + P P   AS P  +  + +  P EE E 
Sbjct: 4915 SPPPSPLAPSPASPPTEPLVELPTEPLAEPPV-PSPLPLASSPESARPKPRARPPEEGED 4973

Query: 737  PESP 740
               P
Sbjct: 4974 SRPP 4977


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  114 bits (285), Expect = 6e-25
 Identities = 138/480 (28%), Positives = 160/480 (33%), Gaps = 99/480 (20%)

Query: 134 SIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTG 193
           ++ S  ++  D       S     P   PP     PQ P S P +P+          P G
Sbjct: 12  ALSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGP-------PPQG 64

Query: 194 YHAPMEPPTSRMFQAPPGAPP-PHPQLYPGGTGGVLSGPPMGPKGGGAAS-SVGGPNGGK 251
            + P  PP       PPG P  P PQ      G    G P GP   G  S S   P G  
Sbjct: 65  GNQPQGPP------PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKP 118

Query: 252 QHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLN 311
           Q PPP      +       PP KP   P  GGN P  PPP   P       PPP     +
Sbjct: 119 QGPPPQ---GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ-----GPPPQGDNKS 170

Query: 312 NASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPM 371
            +S SPPG    P P          QG G  P GP   P     P   PP   + P  P 
Sbjct: 171 RSSRSPPGKPQGPPP----------QG-GNQPQGPPPPP---GKPQGPPPQGGNKPQGP- 215

Query: 372 RFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPS 431
                             + S S+ SP       P  P   PPP      NQP       
Sbjct: 216 ----PPPGKPQGPPPQGDNKSQSARSP-------PGKPQG-PPPQG---GNQP------- 253

Query: 432 LPSQAVWSQGPPPPP--PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489
                   QGPPPPP  P G      N   GP PP  G      P   +     +    +
Sbjct: 254 --------QGPPPPPGKPQGPPPQGGNKPQGPPPP--GKPQGPPPQGGSKSRSSRSPPGK 303

Query: 490 QQQQQQQQQQQQQHHGNSGPPPPGAFPH--PLEGGSSHHAHPYAMSPSLGSLRPYPPGPA 547
            Q    Q   Q Q     GPPPP   P   P +GG+     P             PPG  
Sbjct: 304 PQGPPPQGGNQPQ-----GPPPPPGKPQGPPPQGGNKPQGPP-------------PPGKP 345

Query: 548 HLPPPH----SQVSYSQAG-PNGPPVSSSSN-SSSSTSQGSYPCSHPSPSQG-PQGAPYP 600
             PPP     S+ + S  G P GPP    +N        G  P    +P  G PQG P P
Sbjct: 346 QGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRP 405



 Score =  107 bits (267), Expect = 7e-23
 Identities = 147/508 (28%), Positives = 164/508 (32%), Gaps = 137/508 (26%)

Query: 263 SSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGA 322
           S S  +G P   PP     GGN P  PP    P   P  PPP       N    PP    
Sbjct: 28  SPSLIAGNPQGAPPQ----GGNKPQGPPS---PPGKPQGPPPQG----GNQPQGPP---- 72

Query: 323 QPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSS 382
            P PG    P   G   G  P GP             PP     P P             
Sbjct: 73  -PPPGKPQGPPPQG---GNKPQGPP------------PPGKPQGPPP------------- 103

Query: 383 AAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGP 442
                    S S  SP       P  P   PPP      NQP               QGP
Sbjct: 104 -----QGDKSRSPRSP-------PGKPQG-PPPQG---GNQP---------------QGP 132

Query: 443 PPPP--PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQ 500
           PPPP  P G      N   GP PP    +    PP   +     +    + Q    Q   
Sbjct: 133 PPPPGKPQGPPPQGGNKPQGPPPPG---KPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGN 189

Query: 501 QQHHGNSGPPPPGAFPH--PLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPH----S 554
           Q      GPPPP   P   P +GG+     P             PPG    PPP     S
Sbjct: 190 QPQ----GPPPPPGKPQGPPPQGGNKPQGPP-------------PPGKPQGPPPQGDNKS 232

Query: 555 QVSYSQAG-PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQG--PQGAPYPFPPV-PTVTTS 610
           Q + S  G P GPP    +           P   P P  G  PQG P P  P  P     
Sbjct: 233 QSARSPPGKPQGPPPQGGNQPQGPPPPPGKP-QGPPPQGGNKPQGPPPPGKPQGPPPQGG 291

Query: 611 SATLSTVIATVASSPAGYKTASPPGPPPYG---KRAPSPGAYKTATPP---GYKPGSPPS 664
           S + S+       SP G     P GPPP G    + P P   K   PP   G KP  PP 
Sbjct: 292 SKSRSS------RSPPG----KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP- 340

Query: 665 FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSAT 724
                PPG     PP G    +      G    PP      P  PPP   PA G P    
Sbjct: 341 -----PPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPP---PAGGNP---Q 389

Query: 725 QIKQEPAEEYETPESPVPPARSPSPPPK 752
           Q +  PA + + P  P P    PS PP+
Sbjct: 390 QPQAPPAGQPQGPPRP-PQGGRPSRPPQ 416



 Score =  105 bits (263), Expect = 2e-22
 Identities = 128/475 (26%), Positives = 159/475 (33%), Gaps = 115/475 (24%)

Query: 119 SDPRDIDQD-NRSTSPSIYS---PGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDS 174
           S  +++++D ++  SPS+ +    G+     +   G    P +P  PPP     PQ P  
Sbjct: 14  SSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPP 73

Query: 175 TPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPG---------APPPHPQLYPGGTG 225
            P +P+          P G + P  PP     Q PP          +PP  PQ  P   G
Sbjct: 74  PPGKPQGP-------PPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGG 126

Query: 226 GVLSGPP------MGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKP---- 275
               GPP       GP   G     G P  GK   PP  P   + S +S +PP KP    
Sbjct: 127 NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP--PQGDNKSRSSRSPPGKPQGPP 184

Query: 276 -------------PTTPVG----GGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPP 318
                        P  P G    GGN P  PPP   P       PPP     + ++ SPP
Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ-----GPPPQGDNKSQSARSPP 239

Query: 319 GLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSS 378
           G    P P          QG G  P GP   P     P   PP   + P  P        
Sbjct: 240 GKPQGPPP----------QG-GNQPQGPPPPP---GKPQGPPPQGGNKPQGP-----PPP 280

Query: 379 SSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVW 438
                      S S SS SP       P  P   PPP      NQP              
Sbjct: 281 GKPQGPPPQGGSKSRSSRSP-------PGKPQG-PPPQG---GNQP-------------- 315

Query: 439 SQGPPPPP--PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQ 496
            QGPPPPP  P G      N   GP PP    +    PP        + +  +    + Q
Sbjct: 316 -QGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQGPPP----QGGSKSRSARSPPGKPQ 367

Query: 497 QQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP 551
              QQ+ +   GPPPP        GG+             G  RP   G    PP
Sbjct: 368 GPPQQEGNNPQGPPPPA-------GGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415



 Score =  105 bits (261), Expect = 3e-22
 Identities = 111/396 (28%), Positives = 131/396 (33%), Gaps = 74/396 (18%)

Query: 380 SSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSN--QPPKYTQPSLPSQAV 437
           S +  A SS+ + +   S   +   +   P   PP           PP   Q   P    
Sbjct: 7   SVALLALSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGN 66

Query: 438 WSQGPPPPP--PYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQ 495
             QGPPPPP  P G      N   GP PP    +    PP        +    + Q    
Sbjct: 67  QPQGPPPPPGKPQGPPPQGGNKPQGPPPPG---KPQGPPPQGDKSRSPRSPPGKPQGPPP 123

Query: 496 QQQQQQQHHGNSGPPPPGAFPH--PLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPH 553
           Q   Q Q     GPPPP   P   P +GG+     P             PPG    PPP 
Sbjct: 124 QGGNQPQ-----GPPPPPGKPQGPPPQGGNKPQGPP-------------PPGKPQGPPPQ 165

Query: 554 ----SQVSYSQAG-PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPF------P 602
               S+ S S  G P GPP             G+ P   P P   PQG P         P
Sbjct: 166 GDNKSRSSRSPPGKPQGPPPQG----------GNQPQGPPPPPGKPQGPPPQGGNKPQGP 215

Query: 603 PVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYG---KRAPSPGAYKTATPP---G 656
           P P             +  A SP G     P GPPP G    + P P   K   PP   G
Sbjct: 216 PPPGKPQGPPPQGDNKSQSARSPPG----KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 271

Query: 657 YKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPA 716
            KP  PP      PPG     PP G    +      G    PP      P  PPPP    
Sbjct: 272 NKPQGPP------PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 325

Query: 717 SGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPK 752
            GP          P +    P+ P PP +   PPP+
Sbjct: 326 QGP----------PPQGGNKPQGPPPPGKPQGPPPQ 351



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 71/233 (30%), Positives = 81/233 (34%), Gaps = 55/233 (23%)

Query: 541 PYPPGPAHLPPPHSQVSYSQAG--PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAP 598
           P PPG    PPP       Q G  P GPP             G+ P   P P + PQG P
Sbjct: 51  PSPPGKPQGPPP-------QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK-PQGPP 102

Query: 599 YPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYG---KRAPSPGAYKTATPP 655
                 P    S +           SP G     P GPPP G    + P P   K   PP
Sbjct: 103 ------PQGDKSRSP---------RSPPG----KPQGPPPQGGNQPQGPPPPPGKPQGPP 143

Query: 656 ---GYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPP 712
              G KP  PP      PPG     PP G    +      G    PP      P  PPPP
Sbjct: 144 PQGGNKPQGPP------PPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 197

Query: 713 AAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSAR 765
                GP          P +    P+ P PP +   PPP+      + SQSAR
Sbjct: 198 PGKPQGP----------PPQGGNKPQGPPPPGKPQGPPPQ----GDNKSQSAR 236



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 63/204 (30%), Positives = 75/204 (36%), Gaps = 49/204 (24%)

Query: 568 VSSSSNSSSSTSQGSYPCSHPSPSQG--PQGAPYPFPPVPTVTTSSATLSTVIATVASSP 625
           +SS+ N +   SQ   P       QG  PQG   P  P                    SP
Sbjct: 13  LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGP-------------------PSP 53

Query: 626 AGYKTASPPGPPPYG---KRAPSPGAYKTATPP---GYKPGSPPSFRTGTPPGYRGTSPP 679
            G     P GPPP G    + P P   K   PP   G KP  PP      PPG     PP
Sbjct: 54  PG----KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP------PPGKPQGPPP 103

Query: 680 AGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPES 739
            G  +  P SP   P   PP G +     PPPP  P   PP    +           P+ 
Sbjct: 104 QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK-----------PQG 152

Query: 740 PVPPARSPSPPPKVVDVPSHASQS 763
           P PP +   PPP+  D  S +S+S
Sbjct: 153 PPPPGKPQGPPPQ-GDNKSRSSRS 175


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score =  111 bits (277), Expect = 5e-24
 Identities = 215/899 (23%), Positives = 297/899 (33%), Gaps = 218/899 (24%)

Query: 25   EELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEE-----ASTPKVNKQGRSEEISES 79
            E+L +  +           D K +K  +  +K  VEE     A  P   K  ++   + +
Sbjct: 523  EQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSN 582

Query: 80   ESEETNAPKKTK-------TEQELPRPQS-------PSDLDSLDGRSLN----------- 114
             S++  AP K+K        E++  +P S         D++ L G  L            
Sbjct: 583  VSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREP 642

Query: 115  DDGSSDPRDIDQDNRSTSPSIY---------------SPGSVENDSDSSSGLSQGPARPY 159
               +S+P +I+ D  +  PS                  P + + D  + S   +G +   
Sbjct: 643  SLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSE 702

Query: 160  HPPPLFPPSPQPPDS-TPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP---PGAPPP 215
                    S    DS T   P++  + HP      +H        +M QAP   P  PPP
Sbjct: 703  SESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHH---HHHHQQMQQAPAPVPQQPPP 759

Query: 216  HPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKP 275
             PQ  P         PP  P+              +Q PPP  P           PP+ P
Sbjct: 760  PPQQPP---------PPPPPQ-------------QQQQPPPPPP-----------PPSMP 786

Query: 276  PTTPVGGGNLPSAPPP---ANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSP 332
                     + S+PPP      P + P LP          +   P G   QP+  HLP P
Sbjct: 787  QQAAPA---MKSSPPPFIATQVPVLEPQLP---------GSVFDPIGHFTQPIL-HLPQP 833

Query: 333  HAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYS-SSSSSSAAASSSSSS 391
                     LPP   + P  +  PH    A  S PA     P   S  S+ AAA     +
Sbjct: 834  E--------LPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPA 885

Query: 392  SSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRL 451
               + SP      L   P    PP  L    +PP     S+  Q    Q     P     
Sbjct: 886  RPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQP----- 940

Query: 452  LANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQ-----QQQQQQQQQQQHHGN 506
                   P P  PS   QS   PP+    H   QQQ QQQ       Q Q   QQQH   
Sbjct: 941  -------PTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQ-- 991

Query: 507  SGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPH----SQVSYSQAG 562
              PPP      P++  S+H   P    P  G   P+PP     PPP      QV      
Sbjct: 992  --PPPRPVHLQPMQ-FSTHIQQP---PPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHS 1045

Query: 563  PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGP-QGAPYPFPPVPTVTTSSATLSTVIATV 621
            P      S   S+    +   P    SP     Q   +  PP   V      L       
Sbjct: 1046 PRHH--KSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQEL------- 1096

Query: 622  ASSPAGYKTASPPGPPPY----GKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS 677
                   + AS   P P      ++  SP        P  +P  P    +   P +    
Sbjct: 1097 -------RAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQR 1149

Query: 678  PPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETP 737
            P   P     G P + P P   A         PPP AP         + KQEP       
Sbjct: 1150 PEMKP--VDVGRPVIRP-PEQNA---------PPPGAP------DKDKQKQEP------- 1184

Query: 738  ESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRA 797
                   ++P  P K + + +  S ++   KH                P   S  AK  +
Sbjct: 1185 -------KTPVAPKKDLKIKNMGSWASLVQKH----------------PTTPSSTAKSSS 1221

Query: 798  DLVEKVRREAEQRAREEK---------ERERERER-EKEREREKERELERSVKLAQEGR 846
            D  E+ RR A ++   EK         E+E+ER R E+ R RE E  LE++ +  +E R
Sbjct: 1222 DSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEAR 1280



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 197/901 (21%), Positives = 294/901 (32%), Gaps = 187/901 (20%)

Query: 4    RQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEAS 63
            ++ K + S  S   K+ P P        ++ P     S  + K +      K+    + +
Sbjct: 571  KKTKKNNSSNSNVSKKEPAPM-------KSKPPPTYESEEEDKCKPMSYEEKRQLSLDIN 623

Query: 64   TPKVNKQGRSEEISESE--SEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDP 121
                 K GR   I +S   S + + P + + + E  +P +  +L+      L        
Sbjct: 624  KLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQA 683

Query: 122  RDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEA 181
              +D    S+    +S    E+ S+SSS  S+                     T   P++
Sbjct: 684  EKVDVIAGSSKMKGFSSSESESSSESSSSDSED------------------SETEMAPKS 725

Query: 182  SFEPHPSVTPTGYHAPMEPPTSRMFQAP---PGAPPPHPQLYPGGTGGVLSGPPMGPKGG 238
              + HP      +H        +M QAP   P  PPP PQ  P         PP  P+  
Sbjct: 726  KKKGHPGREQKKHHHHHH---QQMQQAPAPVPQQPPPPPQQPP---------PPPPPQQ- 772

Query: 239  GAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPP---ANFP 295
                        +Q PPP  P           PP+ P         + S+PPP      P
Sbjct: 773  ------------QQQPPPPPP-----------PPSMPQQAAPA---MKSSPPPFIATQVP 806

Query: 296  HVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPS 355
             + P LP          +   P G   QP+  HLP P         LPP   + P  +  
Sbjct: 807  VLEPQLP---------GSVFDPIGHFTQPIL-HLPQPE--------LPPHLPQPPEHSTP 848

Query: 356  PHSLPPASSSAPAPPMRFPYSSSSSSS-AAASSSSSSSSSSASPFPASQALPSYPHSFPP 414
            PH    A  S PA     P   S  S+ AAA     +   + SP      L   P    P
Sbjct: 849  PHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQP 908

Query: 415  PTSLSVSNQPPK----------YTQ---------PSLPSQAVWSQGPPP--PPPYGRLLA 453
            P  L    +PP           Y Q         P LPS  V SQ PPP  PPP+  +  
Sbjct: 909  PQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQ 968

Query: 454  NSNAHPGPFPP---STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP 510
                 P P PP       Q    PP    H    Q     QQ    Q QQ  H      P
Sbjct: 969  QLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPH------P 1022

Query: 511  PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
            PPG  P P +         +  SP      PY  G     P    +   Q          
Sbjct: 1023 PPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQM--------- 1073

Query: 571  SSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKT 630
             S   S T Q S P  +  P +    A     P P V      + + I  + S P  +  
Sbjct: 1074 -SQFQSLTHQ-SPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPI--IRSEP--FSP 1127

Query: 631  ASPPGPPPYGKRAPSPGAYKTATPPGYKP---GSP---PSFRTGTPPGYRGTSPPAGPGT 684
            +  P PP + +   +P        P  KP   G P   P  +   PPG    +P      
Sbjct: 1128 SLRPEPPKHPESIKAP--VHLPQRPEMKPVDVGRPVIRPPEQNAPPPG----APDKDKQK 1181

Query: 685  FKPGSPTVGPGPLPPAGPSGLPSL----PPPPAAPASGPPLSATQIKQEPAEEYETPESP 740
             +P +P      L         SL    P  P++ A     S  Q ++   E+ E  ++ 
Sbjct: 1182 QEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKAL 1241

Query: 741  VPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLV 800
               A          +      +  R     D      AR           + A++R +  
Sbjct: 1242 KAQAEH-------AEKEKERLRQERMRSREDEDALEQAR--------RAHEEARRRQEQQ 1286

Query: 801  EKVRREAEQRAREEK--------------------EREREREREKEREREKERELERSVK 840
            ++ R+E +Q+ +++                     +++RE  R++E+ER +   +  ++ 
Sbjct: 1287 QQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATID 1346

Query: 841  L 841
            +
Sbjct: 1347 M 1347



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 50/196 (25%), Positives = 71/196 (36%), Gaps = 37/196 (18%)

Query: 560 QAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGP---QGAPYPFPPVPTVTTSSATLST 616
           + G   P VS+  N    T+Q S P    +P   P   Q  P+PFP V    T    + T
Sbjct: 185 ETGTAKPGVSTVPN----TTQASTPPQTQTPQPNPPPVQATPHPFPAV----TPDLIVQT 236

Query: 617 VIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGT 676
            + TV   P   +T  P  P P    AP+P   ++  P       P   + G       T
Sbjct: 237 PVMTVVP-PQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTT 295

Query: 677 SPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYET 736
           +P            T+ P   PP       SLPP P     G        ++E +   + 
Sbjct: 296 TPT-----------TIDPIHEPP-------SLPPEPKTTKLGQ-------RRESSRPVKP 330

Query: 737 PESPVPPARSPSPPPK 752
           P+  VP ++    P K
Sbjct: 331 PKKDVPDSQQHPAPEK 346



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/136 (28%), Positives = 52/136 (38%), Gaps = 10/136 (7%)

Query: 166 PPSPQPPDSTPRQPEASFEPHPSVTP--TGYHAPMEPPTSRMFQAPPGAPP-PHPQLYPG 222
           PP  Q P   P   +A+  P P+VTP        M     +  Q PP  PP P P   P 
Sbjct: 205 PPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAP- 263

Query: 223 GTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVG- 281
               V S PP+          V    G K+    TTP ++       + P +P TT +G 
Sbjct: 264 APQPVQSHPPI---IAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQ 320

Query: 282 --GGNLPSAPPPANFP 295
               + P  PP  + P
Sbjct: 321 RRESSRPVKPPKKDVP 336



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 29/85 (34%), Positives = 34/85 (40%), Gaps = 8/85 (9%)

Query: 683 GTFKPGSPTVG---PGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPE- 738
           GT KPG  TV        PP   +  P+ PP  A P   P ++   I Q P      P+ 
Sbjct: 187 GTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQP 246

Query: 739 ----SPVPPARSPSPPPKVVDVPSH 759
                PVPP   P P P    V SH
Sbjct: 247 LQTPPPVPPQPQPPPAPAPQPVQSH 271



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 35/118 (29%), Positives = 40/118 (33%), Gaps = 18/118 (15%)

Query: 155 PARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHA---------PMEPPTSRM 205
           P +P   PP  PP PQPP +   QP  S  P  + TP                 P T   
Sbjct: 243 PPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDP 302

Query: 206 FQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVS 263
              PP   PP P+    G     S P   PK     S        +QHP P     VS
Sbjct: 303 IHEPPSL-PPEPKTTKLGQRRESSRPVKPPKKDVPDS--------QQHPAPEKSSKVS 351



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 20/115 (17%)

Query: 735 ETPESPVPPARSPS--PPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKL 792
           + PE PV    SP+  PP KVV  PS +  S+  +   D   +               + 
Sbjct: 459 DEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDD-----------SEEER 507

Query: 793 AKKRADLVEKVRREAEQRA-------REEKEREREREREKEREREKERELERSVK 840
           A++ A+L E+++   EQ A        + K++E++++ +K+ + +++ E+E + K
Sbjct: 508 AQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKK 562



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 26/96 (27%), Positives = 37/96 (38%), Gaps = 15/96 (15%)

Query: 381 SSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQ 440
           S+   ++ +S+   + +P P    + + PH FP  T   +   P     P  P Q     
Sbjct: 194 STVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQT---- 249

Query: 441 GPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPV 476
            PPP PP           P P P     QS  HPP+
Sbjct: 250 -PPPVPP--------QPQPPPAPAPQPVQS--HPPI 274



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 40/172 (23%), Positives = 63/172 (36%), Gaps = 18/172 (10%)

Query: 274 KPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPH 333
           KP  + V      S PP    P   PN PPP    P    + +P  +   P+   +P P 
Sbjct: 190 KPGVSTVPNTTQASTPPQTQTPQ--PN-PPPVQATPHPFPAVTPDLIVQTPVMTVVP-PQ 245

Query: 334 AMGQGMGGLPPGPEKGPTLAPSP-HSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSS 392
            + Q    +PP P+  P  AP P  S PP  ++ P P          +       + +++
Sbjct: 246 PL-QTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQP--------VKTKKGVKRKADTTT 296

Query: 393 SSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPP 444
            ++  P     +LP  P +    T L    +  +  +P         Q P P
Sbjct: 297 PTTIDPIHEPPSLPPEPKT----TKLGQRRESSRPVKPPKKDVPDSQQHPAP 344



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 33/114 (28%), Positives = 38/114 (33%), Gaps = 25/114 (21%)

Query: 471 TAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPY 530
           TA P VST  +  Q     Q Q  Q             PPP  A PHP            
Sbjct: 188 TAKPGVSTVPNTTQASTPPQTQTPQPN-----------PPPVQATPHPFP---------- 226

Query: 531 AMSPSLGSLRPY----PPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQ 580
           A++P L    P     PP P   PPP          P   PV S     ++T Q
Sbjct: 227 AVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQ 280


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score =  108 bits (269), Expect = 4e-23
 Identities = 205/847 (24%), Positives = 271/847 (31%), Gaps = 157/847 (18%)

Query: 24  REELRSRGRASPGGVSTSSSDGKAEKSRQTAK--------KARVEEASTPKVNKQGRSEE 75
           R E +  GR SP  +S   S  + +   +           +     A +  VNK    + 
Sbjct: 120 RSEQKLPGR-SPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDL 178

Query: 76  ISESESEETNAPKKTKT---EQELP----------RPQSPSDLDSLDGRS-LNDDG---- 117
           IS+SE+ +    KK K    EQ  P          +P  P       GR  L  DG    
Sbjct: 179 ISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS 238

Query: 118 --SSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYH--------------- 160
             S  P  I      T   I  P        +   L +  +RP                 
Sbjct: 239 ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSL 298

Query: 161 PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP--TSRMFQAPPGAPPPHPQ 218
           P P  PP  QP   TP +P A    H    P     P +P   T  + Q P    PP   
Sbjct: 299 PSPSKPPIQQP---TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPP--- 352

Query: 219 LYPGGTGGVLSGPPMGPKGGGA--ASSVGGPNGGKQHPPPTT---PISVSSSGASGAPPT 273
           + P GT    + PP  P G     A   G      + P P     P  V  + A    P 
Sbjct: 353 VQPPGT----TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA 408

Query: 274 KPPTTPVGGGNLPSAPPPANFPHV-TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSP 332
           KPPT  VG     +  P A  P + +P   P P   P+            QP PG +P+ 
Sbjct: 409 KPPTQQVG-----TPKPLAQQPGLQSPAKAPGPTKTPVQ-----------QPGPGKIPAQ 452

Query: 333 HAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSS 392
            A          GP K P+  P P   PP       PP + P     S+   +    S+ 
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP----GSAKPPSQQPGSTK 508

Query: 393 SSSASPFPASQALPSYPHSFPPPTSLSVSNQP-PKYTQPSLPSQAVWSQGPPPPPPYGRL 451
                P PA  + P  P S  PP+    S +P  +   P+ PS A  S  P      G+ 
Sbjct: 509 PPPQQPGPAKPS-PQQPGSTKPPSQQPGSAKPSAQQPSPAKPS-AQQSTKPVSQTGSGKP 566

Query: 452 LANSNAHP-GPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP 510
           L      P    PPS G   T  P  +T        ++       + Q          P 
Sbjct: 567 LQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPN 626

Query: 511 PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
                PH  E       +        G L P P  P             Q      PV++
Sbjct: 627 -----PHLTEVKEWLCLNCQMKRALGGDLAPVPSSP-------------QPKLKTAPVTT 668

Query: 571 SS--NSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGY 628
           +S  + SS   Q + P    +P Q    AP P  P P V     TL    +  A  P   
Sbjct: 669 TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLV--KQPTLHGSPSAKAKQPPEA 726

Query: 629 KTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGT------------------- 669
            + S P PP   K    P     A     KP  P   +  T                   
Sbjct: 727 DSLSKPAPP---KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKV 783

Query: 670 -PPGYRGTSPPAGPGTFKPGS--PTVGPGPLP--------PAGPSGLPSLPPPPAAPASG 718
                  T+PP    + KP    P  G    P        PA  S + S P P +     
Sbjct: 784 QSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ 843

Query: 719 PPLSATQIKQEPAEEYETPESPVPPAR-----SPSPP----------PKVVDVPSHASQS 763
             +   Q K+EP ++ +T  SP P A+     SP+PP          P     P    QS
Sbjct: 844 KQVDPVQKKEEP-KKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS 902

Query: 764 ARFNKHL 770
            RF+ +L
Sbjct: 903 RRFSLNL 909



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 188/860 (21%), Positives = 285/860 (33%), Gaps = 144/860 (16%)

Query: 37  GVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQ----GRSEEISESESEETNAPKKTKT 92
           G+   S    A +S    +K  ++ +  PK + +    GR  +   S+S  T+     ++
Sbjct: 65  GLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDT---FRS 121

Query: 93  EQELPRPQSPSDLDSLDGRSLND-----DGSSDPRDIDQDNRSTSPSI----YSPGSVEN 143
           EQ+LP  +SPS +   + +S  D       S  P  + + N  ++ S     ++P  + +
Sbjct: 122 EQKLPG-RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLIS 180

Query: 144 DSDSSS------------------GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEP 185
           DS++S                   G+ + P +   P P+  P  Q P   P Q + + + 
Sbjct: 181 DSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPI--PKQQGPGRDPLQQDGTPKS 238

Query: 186 HPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVG 245
             S  P    +   P T +  Q P   P       P                 G +    
Sbjct: 239 ISSQQPEKIKS-QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPS 297

Query: 246 GPNGGK---QHPPPTTPISVSSSGASGAP-PTKPPTTPVGGGNLPSAPPPANFPHVTPNL 301
            P+  K   Q P P  P +         P P KPP  P G     +  P    P V P  
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 302 PPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPP 361
              P  +PL  A       G++      P P A+ Q     PPG  K P   P P   P 
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQ-----PPGVGKTPAQQPGPAKPPT 412

Query: 362 ASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVS 421
                P P  + P    S + A   + +          PA QA P              S
Sbjct: 413 QQVGTPKPLAQQP-GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-----------KTS 460

Query: 422 NQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHH 481
            Q    T+P  PSQ     GP  PPP           PGP  P      +A PP      
Sbjct: 461 AQQTGPTKP--PSQL---PGPAKPPPQ---------QPGPAKPPPQQPGSAKPP-----S 501

Query: 482 HHQQQQQQQQQQQQQQQQQQQHHGNSGPP--------PPGAFPHPLEGGSSHHAHPYAMS 533
                 +   QQ    +   Q  G++ PP        P    P P +  +     P + +
Sbjct: 502 QQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT 561

Query: 534 PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPP-----VSSSSNSSSSTSQGSYPCS-- 586
            S   L+P    P+   PP   +  +             V   +N ++ T   +  CS  
Sbjct: 562 GSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC 621

Query: 587 --HPSP-----------------SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAG 627
             +P+P                 + G   AP P  P P + T  A ++T  A   SSP  
Sbjct: 622 GFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKT--APVTTTSAVSKSSPQP 679

Query: 628 YKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGT---PPGYRGTSPPAGPGT 684
            +T+         K+  +P    +  P   KP  PP  +  T    P  +   PP     
Sbjct: 680 QQTSP--------KKDAAPKQDLSKAPEPKKP--PPLVKQPTLHGSPSAKAKQPPEADSL 729

Query: 685 FKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPL-------SATQIKQEPAEEYET- 736
            KP  P     P  P+     P     P  P    P        SAT     P+ + ++ 
Sbjct: 730 SKPAPP---KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 737 -PESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKK 795
             E   PP ++ S  P     P+    S   +K + R       SD   +   G     K
Sbjct: 787 AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR-----PASDSKIISHPGPSSESK 841

Query: 796 RADLVEKVRREAEQRAREEK 815
               V+ V+++ E +  + K
Sbjct: 842 GQKQVDPVQKKEEPKKAQTK 861



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 186/811 (22%), Positives = 252/811 (31%), Gaps = 139/811 (17%)

Query: 11   SMRSGRKKEAPGP-REELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNK 69
            + + G +K  PGP +   +  G   P      +     +    T   A+    + P   +
Sbjct: 316  AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQ 375

Query: 70   QGRSEEISESESEETNA--PKKTKTEQELPRPQSPSDLDSLDGRSL-NDDGSSDPRDIDQ 126
             G  +  SE    +  A  P   KT  + P P  P        + L    G   P     
Sbjct: 376  TGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPG 435

Query: 127  DNRSTSPSIYSPGSV---ENDSDSSSGLSQGPARPYH--PPPLFPPSPQP-PDSTPRQPE 180
              + T      PG +   +     +S    GP +P    P P  PP  QP P   P Q  
Sbjct: 436  PTK-TPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP 494

Query: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGP-PMGPKGGG 239
             S +P      +    P +P  ++     PG+  P P   PG        P P  P    
Sbjct: 495  GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKP-PSQQPGSAKPSAQQPSPAKPSAQQ 553

Query: 240  AASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP---TTPVGGGNLPSAPPPANF-- 294
            +   V     GK   PPT   S     + G P T  P   TT +    L   P  ANF  
Sbjct: 554  STKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTEL----LLHVPEKANFNT 609

Query: 295  -----------------PHVT-----------------------PNLPPPP-ALRPLNNA 313
                             PH+T                       P+ P P     P+   
Sbjct: 610  CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTT 669

Query: 314  SASPPGLGAQPLPGHL-PSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMR 372
            SA      + P P    P   A  +      P P+K P L   P      S+ A  PP  
Sbjct: 670  SAVSK---SSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPP-- 724

Query: 373  FPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL 432
                 + S S  A     S  S     P +   P  P    P T L  S+     T+P +
Sbjct: 725  ----EADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSAT--TKPDI 778

Query: 433  PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQ-----STAHP------PVSTHHH 481
            PS  V SQ      P    L   +A P    P TG +     S A P       + +H  
Sbjct: 779  PSSKVQSQAEEKTTP---PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPG 835

Query: 482  HHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRP 541
               + + Q+Q    Q++++ +       P P A P P   GS                 P
Sbjct: 836  PSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMP--KGS-----------------P 876

Query: 542  YPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPF 601
             PPGP   P     V   Q  P  P   S   S +  S    P S P+            
Sbjct: 877  TPPGPR--PTAGQTVPTPQQSPK-PQEQSRRFSLNLGSITDAPKSQPT------------ 921

Query: 602  PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGS 661
             P  TVT         I + AS+     TA  PGP         PGA     P    P  
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNL--ISTAGQPGP----HSQSGPGAPMKQAP---APSQ 972

Query: 662  PPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPL 721
            PP+  +  PP   G +PPA   +      T       PA     P     P    +    
Sbjct: 973  PPT--SQGPPKSTGQAPPAPAKSIPVKKETKA-----PAAEKLEPKAEQAPTVKRTETEK 1025

Query: 722  SATQIKQEPAEEYETPESPVPPARSPSPPPK 752
                IK   +   E  ++ +P     SP P+
Sbjct: 1026 KPPPIKDSKSLTAEPQKAVLPTKLEKSPKPE 1056



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 136/590 (23%), Positives = 193/590 (32%), Gaps = 101/590 (17%)

Query: 235 PKGGGAASSVGGPNGGKQHPPPTT------------------PISVSSSGASGAPPTKPP 276
           P+G  AA++ GG   G   P  T                    I+   S A G P     
Sbjct: 13  PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPK---- 68

Query: 277 TTPVGGGNLPSAPPPANFPHVTPNL----PPPPALRPLNNASASPPGLGA---------- 322
                 G++P A   +   H    L    PP  + RP +    + PGL            
Sbjct: 69  ------GSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSE 122

Query: 323 QPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRF-PYSSSSSS 381
           Q LPG  PS  ++ +         E   ++ P   S   A S+  +   +F P+   S S
Sbjct: 123 QKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDS 182

Query: 382 SAAASSSSSSSSSSASPFPASQALPSYPHSFPPP------------------TSLSVSNQ 423
            A+   ++             + +   P    PP                  T  S+S+Q
Sbjct: 183 EASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQ 242

Query: 424 PPKYTQPSLPSQAVWSQGPPPPPP--YGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHH 481
            P+  +   P      QGP   P   + +L    +A     P +  A       V     
Sbjct: 243 QPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASR---PQTKQADIVRGESVKPSLP 299

Query: 482 HHQQQQQQQQQQQQQQQQQQQHHGNS-GPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540
              +   QQ    +   QQ  H  +  GP  P A P  L         P A  P  G+++
Sbjct: 300 SPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL-------TKPLAQQP--GTVK 350

Query: 541 PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600
           P    P    PP   +     GP  PP   + +   S+ Q         P  G   A  P
Sbjct: 351 PPVQPPGTTKPPAQPL-----GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP 405

Query: 601 FPPVPTV----TTSSATLSTVIATVASSPAGYKT-ASPPGPPPYGKRAPSPG---AYKTA 652
            P  P      T         + + A +P   KT    PGP     +   PG   A +T 
Sbjct: 406 GPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTG 465

Query: 653 T--PPGYKPG--SPPSFRTGT---PPGYRGTSPPAG--PGTFKPGSPTVGPGPLPPAGPS 703
              PP   PG   PP  + G    PP   G++ P    PG+ KP  P   PGP  P+ P 
Sbjct: 466 PTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP--PPQQPGPAKPS-PQ 522

Query: 704 GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKV 753
              S  PP   P S  P +      +P+ +  T       +  P  PP V
Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV 572



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 93/441 (21%), Positives = 144/441 (32%), Gaps = 58/441 (13%)

Query: 38   VSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELP 97
            VS+SS+  K +      + ++ EE +TP +         S   + E  +P  +K    +P
Sbjct: 767  VSSSSATTKPDIPSSKVQ-SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKA---IP 822

Query: 98   RPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPAR 157
            RP S S + S  G S    G    + +D   +   P               +     P  
Sbjct: 823  RPASDSKIISHPGPSSESKGQ---KQVDPVQKKEEPK-------------KAQTKMSPKP 866

Query: 158  PYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP 217
               P P   P+P  P  T  Q            PT   +P     SR F    G+    P
Sbjct: 867  DAKPMPKGSPTPPGPRPTAGQ----------TVPTPQQSPKPQEQSRRFSLNLGSITDAP 916

Query: 218  QLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPT 277
            +  P      ++G   G    GA+      N             +S++G  G      P 
Sbjct: 917  KSQPTTPQETVTGKLFG---FGASIFSQASN------------LISTAGQPGPHSQSGPG 961

Query: 278  TPVGGGNLPSAPPPANFP-HVTPNLPPPPALR-PLNNASASPPGLGAQPLPGHLPSPHAM 335
             P+     PS PP +  P   T   PP PA   P+   + +P     +P     P+    
Sbjct: 962  APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 336  GQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                   P    K  T  P    LP     +P P    P   +  +  +    + ++ + 
Sbjct: 1022 ETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTE 1081

Query: 396  ASPFPASQA-LPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLAN 454
                  +       PH       L ++ Q    TQ ++  Q    +  PP P      + 
Sbjct: 1082 CKNQVCNLCGFNPTPHLTEIQEWLCLNCQ----TQRAISGQLGDIRKMPPAP------SG 1131

Query: 455  SNAHPGPFPPSTGAQSTAHPP 475
              A P P P  + +Q TA PP
Sbjct: 1132 PKASPMPVPTESSSQKTAVPP 1152



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 37/115 (32%), Positives = 48/115 (41%), Gaps = 18/115 (15%)

Query: 360  PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLS 419
            PP  SS  A PM+   S++  +S         +S   S  P+  +LP+ P  F   +SL 
Sbjct: 2343 PP--SSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLD 2400

Query: 420  VSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHP 474
            +S QPP    P  P        PPPPPP           P P PP T  + T  P
Sbjct: 2401 ISAQPPPPPPPPPPPPP-----PPPPPP-----------PPPLPPPTSPKPTILP 2439



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 87/426 (20%), Positives = 143/426 (33%), Gaps = 53/426 (12%)

Query: 46   KAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
            KA+K         V EA   K   +    + S SE+   + P        LP  +  S  
Sbjct: 2303 KAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIA---LPMKEQLSTT 2359

Query: 106  DSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLF 165
                G +   +  +        + S+ P+   P    +  D S+     P  P  PPP  
Sbjct: 2360 YFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP 2419

Query: 166  PPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEP-------------------PTSRMF 206
            PP P PP   P  P+ +  P   +T         P                   P +R+ 
Sbjct: 2420 PPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRIC 2479

Query: 207  QAPPGAPPPHPQLYPGGT----GGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPT----- 257
               P   PP P   P G         S PP+ PK                HP PT     
Sbjct: 2480 TTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 258  --TPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASA 315
                +++ +S     P    P +P    + P         +V   LP  P     ++AS 
Sbjct: 2540 SSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQ 2599

Query: 316  S----PPG------LGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365
            +    P G      +  +P+   +P   A+      +P   E+   ++ +  +      +
Sbjct: 2600 AITSWPLGSPSKDLVSVEPVFSVVPPVTAV-----EIPISSEQTFYISGALQTFSATPVT 2654

Query: 366  APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPP-PTSL-SVSNQ 423
            AP+     P S +   +   S +  S++ S +P   S  L S   + PP P +L ++  +
Sbjct: 2655 APSSFQAAPTSVTQFLTTEVSKTEVSATRSTAP---SVGLSSISITIPPEPLALDNIHLE 2711

Query: 424  PPKYTQ 429
             P+Y +
Sbjct: 2712 KPQYKE 2717



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 64/243 (26%), Positives = 82/243 (33%), Gaps = 32/243 (13%)

Query: 551  PPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTS 610
            PP S ++     P    +S++  +S  T     P S   PS  P  +  P  P P   +S
Sbjct: 2343 PPSSVIAL----PMKEQLSTTYFTSGETFGQEKPASQ-LPSGSPSVSSLPAKPRPFFRSS 2397

Query: 611  SATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTP 670
            S  +S         P       PP PPP     P P + K    P  K        T TP
Sbjct: 2398 SLDISAQPPPPPPPPPPPPPPPPPPPPP---PLPPPTSPKPTILPKKKLTVASPVTTATP 2454

Query: 671  PGYRGTSPPAGPGTFKPGSP-----TVGPGPLPP---AGPSGL-----PSLPPPPAAPAS 717
                 T+          G P     T  P P+PP   + PSGL     P    PP AP  
Sbjct: 2455 LFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKP 2514

Query: 718  GPPLSATQIKQEPAEEYETPE----------SPVPPARSPSPPPKVVDVPSHASQSARFN 767
              P   T   Q+P + +  P           + V  A    P P     P     S RF+
Sbjct: 2515 VIPQLPT-TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFS 2573

Query: 768  KHL 770
            K L
Sbjct: 2574 KSL 2576



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 66/271 (24%), Positives = 82/271 (30%), Gaps = 60/271 (22%)

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P+  S SL      PP P   PPP          P  PP S                  P
Sbjct: 2392 PFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTS------------------P 2433

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK-----TASPPGPPPYGKRA 643
             P+  P+       PV T T     ++T+  T      G       T +PP  PP     
Sbjct: 2434 KPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI 2493

Query: 644  PSPGAYKTATPPGYKPGSP----PSFRTGT---------PPGYRGTSPP----AGPGTFK 686
            PS   +     P   P +P    P   T T         P G   TS           +K
Sbjct: 2494 PSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYK 2553

Query: 687  PGSPTVGPGPLPPAGPSGLP-------------SLPPPPAAPASGPPLSATQ-IKQEPAE 732
              SPT    PL P      P             +LP  P  P      SA+Q I   P  
Sbjct: 2554 LPSPT---SPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDS---SASQAITSWPLG 2607

Query: 733  EYETPESPVPPARSPSPPPKVVDVPSHASQS 763
                    V P  S  PP   V++P  + Q+
Sbjct: 2608 SPSKDLVSVEPVFSVVPPVTAVEIPISSEQT 2638



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 85/423 (20%), Positives = 140/423 (33%), Gaps = 54/423 (12%)

Query: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS-------------PFPASQALPS 407
            P+ S+   PP   P  +SS SS   + SSS  ++  S              F  S+ + S
Sbjct: 2169 PSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISS 2228

Query: 408  ---YPHS---FPPPTSLSVSNQPPKYTQPS----------LPSQAVWSQGPPPPPPYGRL 451
               +P S   +P   S+S+    P   + S          + S  + S  P P  P    
Sbjct: 2229 STYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPKPEGPVADT 2288

Query: 452  LANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP 511
            ++         P     + T +  +      ++ +++ + ++ +    +         PP
Sbjct: 2289 VSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDH----PP 2344

Query: 512  PGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSS 571
                  P++   S     +    + G  +P     + LP     VS   A P  P   SS
Sbjct: 2345 SSVIALPMKEQLS--TTYFTSGETFGQEKP----ASQLPSGSPSVSSLPAKPR-PFFRSS 2397

Query: 572  SNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPP--VPTVTTSSATLSTVIATVASSPAGYK 629
            S   S+      P   P P   P   P P PP   P  T       TV + V ++   + 
Sbjct: 2398 SLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFD 2457

Query: 630  TASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS 689
              +        +    P      T P   P  P S     P G   T  P      +P  
Sbjct: 2458 AVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI----PSGLVFTHRP------EPSK 2507

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYE--TPESPVPPARSP 747
            P + P P+ P  P+           P      S+  +    + +Y+  +P SP+ P  + 
Sbjct: 2508 PPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNK 2567

Query: 748  SPP 750
            S P
Sbjct: 2568 SSP 2570



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 68/299 (22%), Positives = 108/299 (36%), Gaps = 53/299 (17%)

Query: 632  SPPGPPP--YGKRAP-SPG-AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKP 687
            SPP  P   Y   +P SPG A ++A  P  KP                  PPA P T K 
Sbjct: 3615 SPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKM 3674

Query: 688  GSPTVG-PGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS 746
               ++  P PL P             A  +S  P   T+       +  T        + 
Sbjct: 3675 MQRSMSDPKPLSPT------------ADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKR 3722

Query: 747  --PSPPPKVVDVPSHASQSARFNKHLDR--GFNSCARS--------DLYFVPLEGSKLAK 794
              P+PPP+ +   + ++ S        R    N+ AR+        +L  V  E +KL K
Sbjct: 3723 TLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRK 3782

Query: 795  KRADLVEKV----------------RREAEQRAREEKEREREREREKEREREKERELERS 838
            K+A+L E+                 R+EA  + RE++ER   +   ++R+   + E+  +
Sbjct: 3783 KQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSST 3842

Query: 839  VKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSP 897
                 E +  +E P   P      F        +PP    ++  +   S Y +    SP
Sbjct: 3843 RPTRIESQHGIERPRTAPQTEFSQF--------IPPQTQTESQLVPPTSPYTQYQYSSP 3893



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 23/136 (16%)

Query: 374  PYSSSSSSSAAASSSS-----------SSSSSSASPFPASQALP-SYPHSFPP----PTS 417
            PYSS S S  ++  SS           SSSSS       ++AL  S+ H+       PTS
Sbjct: 4282 PYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSARTKPTS 4341

Query: 418  LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVS 477
            L +S      ++  +P  A  S+   P  P G+ +  + A  GP PP +    T     S
Sbjct: 4342 LPISQ-----SRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISA--DTRDQFGS 4394

Query: 478  THHHHHQQQQQQQQQQ 493
            +H     QQ  +++ +
Sbjct: 4395 SHSLPEVQQHMREESR 4410



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 2/102 (1%)

Query: 48   EKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDS 107
            EK         V+E   P+   +G      +S  +E +  K TKT +E P+P   +  D 
Sbjct: 1274 EKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDD--KTTKTIKEQPQPPCTAKPDQ 1331

Query: 108  LDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSS 149
            ++      +   D  D     +  SP   S     +D  SSS
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 33/121 (27%), Positives = 47/121 (38%), Gaps = 19/121 (15%)

Query: 360  PPASSSAPAPPMRFPYSS---SSSSSAAASSSSSSSS---SSASPFPASQALPS--YPHS 411
            PP     P P +   YSS   + S+   A S   S     S  SP    +AL S   P+ 
Sbjct: 3586 PPKDKKRPTP-LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644

Query: 412  FPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQST 471
             P P  +S    P K   P +      ++ PP  P   +++  S + P P  P+    S 
Sbjct: 3645 KPLPDDIS----PQKVLHPDM------AKVPPASPKTAKMMQRSMSDPKPLSPTADESSR 3694

Query: 472  A 472
            A
Sbjct: 3695 A 3695



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 38/166 (22%), Positives = 59/166 (35%), Gaps = 19/166 (11%)

Query: 822 EREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPF-EPGSAVATVPPYLGPDT 880
           +R+  R + K+ ++ R   +     +P + P   P P +PP  +PG   +   P   P  
Sbjct: 275 QRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ 334

Query: 881 PALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARER 940
           P     S   +P    PG    P   P         G   P      PA    ++   E+
Sbjct: 335 P-----SGLTKPLAQQPGTVKPPVQPP---------GTTKPPAQPLGPAKPPAQQTGSEK 380

Query: 941 DLRDRLKPGFEVKPSELEPLHG-VPGPGLDPFPRHG---GLALQPG 982
              ++  P    +P  +       PGP   P  + G    LA QPG
Sbjct: 381 PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score =  108 bits (269), Expect = 4e-23
 Identities = 205/847 (24%), Positives = 271/847 (31%), Gaps = 157/847 (18%)

Query: 24  REELRSRGRASPGGVSTSSSDGKAEKSRQTAK--------KARVEEASTPKVNKQGRSEE 75
           R E +  GR SP  +S   S  + +   +           +     A +  VNK    + 
Sbjct: 120 RSEQKLPGR-SPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDL 178

Query: 76  ISESESEETNAPKKTKT---EQELP----------RPQSPSDLDSLDGRS-LNDDG---- 117
           IS+SE+ +    KK K    EQ  P          +P  P       GR  L  DG    
Sbjct: 179 ISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKS 238

Query: 118 --SSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYH--------------- 160
             S  P  I      T   I  P        +   L +  +RP                 
Sbjct: 239 ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSL 298

Query: 161 PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP--TSRMFQAPPGAPPPHPQ 218
           P P  PP  QP   TP +P A    H    P     P +P   T  + Q P    PP   
Sbjct: 299 PSPSKPPIQQP---TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPP--- 352

Query: 219 LYPGGTGGVLSGPPMGPKGGGA--ASSVGGPNGGKQHPPPTT---PISVSSSGASGAPPT 273
           + P GT    + PP  P G     A   G      + P P     P  V  + A    P 
Sbjct: 353 VQPPGT----TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA 408

Query: 274 KPPTTPVGGGNLPSAPPPANFPHV-TPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSP 332
           KPPT  VG     +  P A  P + +P   P P   P+            QP PG +P+ 
Sbjct: 409 KPPTQQVG-----TPKPLAQQPGLQSPAKAPGPTKTPVQ-----------QPGPGKIPAQ 452

Query: 333 HAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSS 392
            A          GP K P+  P P   PP       PP + P     S+   +    S+ 
Sbjct: 453 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP----GSAKPPSQQPGSTK 508

Query: 393 SSSASPFPASQALPSYPHSFPPPTSLSVSNQP-PKYTQPSLPSQAVWSQGPPPPPPYGRL 451
                P PA  + P  P S  PP+    S +P  +   P+ PS A  S  P      G+ 
Sbjct: 509 PPPQQPGPAKPS-PQQPGSTKPPSQQPGSAKPSAQQPSPAKPS-AQQSTKPVSQTGSGKP 566

Query: 452 LANSNAHP-GPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPP 510
           L      P    PPS G   T  P  +T        ++       + Q          P 
Sbjct: 567 LQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPN 626

Query: 511 PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
                PH  E       +        G L P P  P             Q      PV++
Sbjct: 627 -----PHLTEVKEWLCLNCQMKRALGGDLAPVPSSP-------------QPKLKTAPVTT 668

Query: 571 SS--NSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGY 628
           +S  + SS   Q + P    +P Q    AP P  P P V     TL    +  A  P   
Sbjct: 669 TSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLV--KQPTLHGSPSAKAKQPPEA 726

Query: 629 KTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGT------------------- 669
            + S P PP   K    P     A     KP  P   +  T                   
Sbjct: 727 DSLSKPAPP---KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKV 783

Query: 670 -PPGYRGTSPPAGPGTFKPGS--PTVGPGPLP--------PAGPSGLPSLPPPPAAPASG 718
                  T+PP    + KP    P  G    P        PA  S + S P P +     
Sbjct: 784 QSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQ 843

Query: 719 PPLSATQIKQEPAEEYETPESPVPPAR-----SPSPP----------PKVVDVPSHASQS 763
             +   Q K+EP ++ +T  SP P A+     SP+PP          P     P    QS
Sbjct: 844 KQVDPVQKKEEP-KKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS 902

Query: 764 ARFNKHL 770
            RF+ +L
Sbjct: 903 RRFSLNL 909



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 188/860 (21%), Positives = 285/860 (33%), Gaps = 144/860 (16%)

Query: 37  GVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQ----GRSEEISESESEETNAPKKTKT 92
           G+   S    A +S    +K  ++ +  PK + +    GR  +   S+S  T+     ++
Sbjct: 65  GLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDT---FRS 121

Query: 93  EQELPRPQSPSDLDSLDGRSLND-----DGSSDPRDIDQDNRSTSPSI----YSPGSVEN 143
           EQ+LP  +SPS +   + +S  D       S  P  + + N  ++ S     ++P  + +
Sbjct: 122 EQKLPG-RSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLIS 180

Query: 144 DSDSSS------------------GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEP 185
           DS++S                   G+ + P +   P P+  P  Q P   P Q + + + 
Sbjct: 181 DSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPI--PKQQGPGRDPLQQDGTPKS 238

Query: 186 HPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVG 245
             S  P    +   P T +  Q P   P       P                 G +    
Sbjct: 239 ISSQQPEKIKS-QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPS 297

Query: 246 GPNGGK---QHPPPTTPISVSSSGASGAP-PTKPPTTPVGGGNLPSAPPPANFPHVTPNL 301
            P+  K   Q P P  P +         P P KPP  P G     +  P    P V P  
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 302 PPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPP 361
              P  +PL  A       G++      P P A+ Q     PPG  K P   P P   P 
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQ-----PPGVGKTPAQQPGPAKPPT 412

Query: 362 ASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVS 421
                P P  + P    S + A   + +          PA QA P              S
Sbjct: 413 QQVGTPKPLAQQP-GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-----------KTS 460

Query: 422 NQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHH 481
            Q    T+P  PSQ     GP  PPP           PGP  P      +A PP      
Sbjct: 461 AQQTGPTKP--PSQL---PGPAKPPPQ---------QPGPAKPPPQQPGSAKPP-----S 501

Query: 482 HHQQQQQQQQQQQQQQQQQQQHHGNSGPP--------PPGAFPHPLEGGSSHHAHPYAMS 533
                 +   QQ    +   Q  G++ PP        P    P P +  +     P + +
Sbjct: 502 QQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT 561

Query: 534 PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPP-----VSSSSNSSSSTSQGSYPCS-- 586
            S   L+P    P+   PP   +  +             V   +N ++ T   +  CS  
Sbjct: 562 GSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC 621

Query: 587 --HPSP-----------------SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAG 627
             +P+P                 + G   AP P  P P + T  A ++T  A   SSP  
Sbjct: 622 GFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKT--APVTTTSAVSKSSPQP 679

Query: 628 YKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGT---PPGYRGTSPPAGPGT 684
            +T+         K+  +P    +  P   KP  PP  +  T    P  +   PP     
Sbjct: 680 QQTSP--------KKDAAPKQDLSKAPEPKKP--PPLVKQPTLHGSPSAKAKQPPEADSL 729

Query: 685 FKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPL-------SATQIKQEPAEEYET- 736
            KP  P     P  P+     P     P  P    P        SAT     P+ + ++ 
Sbjct: 730 SKPAPP---KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 737 -PESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKK 795
             E   PP ++ S  P     P+    S   +K + R       SD   +   G     K
Sbjct: 787 AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR-----PASDSKIISHPGPSSESK 841

Query: 796 RADLVEKVRREAEQRAREEK 815
               V+ V+++ E +  + K
Sbjct: 842 GQKQVDPVQKKEEPKKAQTK 861



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 186/811 (22%), Positives = 252/811 (31%), Gaps = 139/811 (17%)

Query: 11   SMRSGRKKEAPGP-REELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNK 69
            + + G +K  PGP +   +  G   P      +     +    T   A+    + P   +
Sbjct: 316  AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQ 375

Query: 70   QGRSEEISESESEETNA--PKKTKTEQELPRPQSPSDLDSLDGRSL-NDDGSSDPRDIDQ 126
             G  +  SE    +  A  P   KT  + P P  P        + L    G   P     
Sbjct: 376  TGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPG 435

Query: 127  DNRSTSPSIYSPGSV---ENDSDSSSGLSQGPARPYH--PPPLFPPSPQP-PDSTPRQPE 180
              + T      PG +   +     +S    GP +P    P P  PP  QP P   P Q  
Sbjct: 436  PTK-TPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQP 494

Query: 181  ASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGP-PMGPKGGG 239
             S +P      +    P +P  ++     PG+  P P   PG        P P  P    
Sbjct: 495  GSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKP-PSQQPGSAKPSAQQPSPAKPSAQQ 553

Query: 240  AASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP---TTPVGGGNLPSAPPPANF-- 294
            +   V     GK   PPT   S     + G P T  P   TT +    L   P  ANF  
Sbjct: 554  STKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTEL----LLHVPEKANFNT 609

Query: 295  -----------------PHVT-----------------------PNLPPPP-ALRPLNNA 313
                             PH+T                       P+ P P     P+   
Sbjct: 610  CTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTT 669

Query: 314  SASPPGLGAQPLPGHL-PSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMR 372
            SA      + P P    P   A  +      P P+K P L   P      S+ A  PP  
Sbjct: 670  SAVSK---SSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPP-- 724

Query: 373  FPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL 432
                 + S S  A     S  S     P +   P  P    P T L  S+     T+P +
Sbjct: 725  ----EADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSAT--TKPDI 778

Query: 433  PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQ-----STAHP------PVSTHHH 481
            PS  V SQ      P    L   +A P    P TG +     S A P       + +H  
Sbjct: 779  PSSKVQSQAEEKTTP---PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPG 835

Query: 482  HHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRP 541
               + + Q+Q    Q++++ +       P P A P P   GS                 P
Sbjct: 836  PSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMP--KGS-----------------P 876

Query: 542  YPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPF 601
             PPGP   P     V   Q  P  P   S   S +  S    P S P+            
Sbjct: 877  TPPGPR--PTAGQTVPTPQQSPK-PQEQSRRFSLNLGSITDAPKSQPT------------ 921

Query: 602  PPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGS 661
             P  TVT         I + AS+     TA  PGP         PGA     P    P  
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNL--ISTAGQPGP----HSQSGPGAPMKQAP---APSQ 972

Query: 662  PPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPL 721
            PP+  +  PP   G +PPA   +      T       PA     P     P    +    
Sbjct: 973  PPT--SQGPPKSTGQAPPAPAKSIPVKKETKA-----PAAEKLEPKAEQAPTVKRTETEK 1025

Query: 722  SATQIKQEPAEEYETPESPVPPARSPSPPPK 752
                IK   +   E  ++ +P     SP P+
Sbjct: 1026 KPPPIKDSKSLTAEPQKAVLPTKLEKSPKPE 1056



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 136/590 (23%), Positives = 193/590 (32%), Gaps = 101/590 (17%)

Query: 235 PKGGGAASSVGGPNGGKQHPPPTT------------------PISVSSSGASGAPPTKPP 276
           P+G  AA++ GG   G   P  T                    I+   S A G P     
Sbjct: 13  PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPK---- 68

Query: 277 TTPVGGGNLPSAPPPANFPHVTPNL----PPPPALRPLNNASASPPGLGA---------- 322
                 G++P A   +   H    L    PP  + RP +    + PGL            
Sbjct: 69  ------GSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSE 122

Query: 323 QPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRF-PYSSSSSS 381
           Q LPG  PS  ++ +         E   ++ P   S   A S+  +   +F P+   S S
Sbjct: 123 QKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDS 182

Query: 382 SAAASSSSSSSSSSASPFPASQALPSYPHSFPPP------------------TSLSVSNQ 423
            A+   ++             + +   P    PP                  T  S+S+Q
Sbjct: 183 EASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQ 242

Query: 424 PPKYTQPSLPSQAVWSQGPPPPPP--YGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHH 481
            P+  +   P      QGP   P   + +L    +A     P +  A       V     
Sbjct: 243 QPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASR---PQTKQADIVRGESVKPSLP 299

Query: 482 HHQQQQQQQQQQQQQQQQQQQHHGNS-GPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540
              +   QQ    +   QQ  H  +  GP  P A P  L         P A  P  G+++
Sbjct: 300 SPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL-------TKPLAQQP--GTVK 350

Query: 541 PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600
           P    P    PP   +     GP  PP   + +   S+ Q         P  G   A  P
Sbjct: 351 PPVQPPGTTKPPAQPL-----GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQP 405

Query: 601 FPPVPTV----TTSSATLSTVIATVASSPAGYKT-ASPPGPPPYGKRAPSPG---AYKTA 652
            P  P      T         + + A +P   KT    PGP     +   PG   A +T 
Sbjct: 406 GPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTG 465

Query: 653 T--PPGYKPG--SPPSFRTGT---PPGYRGTSPPAG--PGTFKPGSPTVGPGPLPPAGPS 703
              PP   PG   PP  + G    PP   G++ P    PG+ KP  P   PGP  P+ P 
Sbjct: 466 PTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP--PPQQPGPAKPS-PQ 522

Query: 704 GLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKV 753
              S  PP   P S  P +      +P+ +  T       +  P  PP V
Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV 572



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 93/441 (21%), Positives = 144/441 (32%), Gaps = 58/441 (13%)

Query: 38   VSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELP 97
            VS+SS+  K +      + ++ EE +TP +         S   + E  +P  +K    +P
Sbjct: 767  VSSSSATTKPDIPSSKVQ-SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKA---IP 822

Query: 98   RPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPAR 157
            RP S S + S  G S    G    + +D   +   P               +     P  
Sbjct: 823  RPASDSKIISHPGPSSESKGQ---KQVDPVQKKEEPK-------------KAQTKMSPKP 866

Query: 158  PYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP 217
               P P   P+P  P  T  Q            PT   +P     SR F    G+    P
Sbjct: 867  DAKPMPKGSPTPPGPRPTAGQ----------TVPTPQQSPKPQEQSRRFSLNLGSITDAP 916

Query: 218  QLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPT 277
            +  P      ++G   G    GA+      N             +S++G  G      P 
Sbjct: 917  KSQPTTPQETVTGKLFG---FGASIFSQASN------------LISTAGQPGPHSQSGPG 961

Query: 278  TPVGGGNLPSAPPPANFP-HVTPNLPPPPALR-PLNNASASPPGLGAQPLPGHLPSPHAM 335
             P+     PS PP +  P   T   PP PA   P+   + +P     +P     P+    
Sbjct: 962  APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021

Query: 336  GQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSS 395
                   P    K  T  P    LP     +P P    P   +  +  +    + ++ + 
Sbjct: 1022 ETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTE 1081

Query: 396  ASPFPASQA-LPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLAN 454
                  +       PH       L ++ Q    TQ ++  Q    +  PP P      + 
Sbjct: 1082 CKNQVCNLCGFNPTPHLTEIQEWLCLNCQ----TQRAISGQLGDIRKMPPAP------SG 1131

Query: 455  SNAHPGPFPPSTGAQSTAHPP 475
              A P P P  + +Q TA PP
Sbjct: 1132 PKASPMPVPTESSSQKTAVPP 1152



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 37/115 (32%), Positives = 48/115 (41%), Gaps = 18/115 (15%)

Query: 360  PPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLS 419
            PP  SS  A PM+   S++  +S         +S   S  P+  +LP+ P  F   +SL 
Sbjct: 2343 PP--SSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLD 2400

Query: 420  VSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHP 474
            +S QPP    P  P        PPPPPP           P P PP T  + T  P
Sbjct: 2401 ISAQPPPPPPPPPPPPP-----PPPPPP-----------PPPLPPPTSPKPTILP 2439



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 87/426 (20%), Positives = 143/426 (33%), Gaps = 53/426 (12%)

Query: 46   KAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDL 105
            KA+K         V EA   K   +    + S SE+   + P        LP  +  S  
Sbjct: 2303 KAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIA---LPMKEQLSTT 2359

Query: 106  DSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLF 165
                G +   +  +        + S+ P+   P    +  D S+     P  P  PPP  
Sbjct: 2360 YFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPP 2419

Query: 166  PPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEP-------------------PTSRMF 206
            PP P PP   P  P+ +  P   +T         P                   P +R+ 
Sbjct: 2420 PPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRIC 2479

Query: 207  QAPPGAPPPHPQLYPGGT----GGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPT----- 257
               P   PP P   P G         S PP+ PK                HP PT     
Sbjct: 2480 TTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLT 2539

Query: 258  --TPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASA 315
                +++ +S     P    P +P    + P         +V   LP  P     ++AS 
Sbjct: 2540 SSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQ 2599

Query: 316  S----PPG------LGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365
            +    P G      +  +P+   +P   A+      +P   E+   ++ +  +      +
Sbjct: 2600 AITSWPLGSPSKDLVSVEPVFSVVPPVTAV-----EIPISSEQTFYISGALQTFSATPVT 2654

Query: 366  APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPP-PTSL-SVSNQ 423
            AP+     P S +   +   S +  S++ S +P   S  L S   + PP P +L ++  +
Sbjct: 2655 APSSFQAAPTSVTQFLTTEVSKTEVSATRSTAP---SVGLSSISITIPPEPLALDNIHLE 2711

Query: 424  PPKYTQ 429
             P+Y +
Sbjct: 2712 KPQYKE 2717



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 64/243 (26%), Positives = 82/243 (33%), Gaps = 32/243 (13%)

Query: 551  PPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTS 610
            PP S ++     P    +S++  +S  T     P S   PS  P  +  P  P P   +S
Sbjct: 2343 PPSSVIAL----PMKEQLSTTYFTSGETFGQEKPASQ-LPSGSPSVSSLPAKPRPFFRSS 2397

Query: 611  SATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTP 670
            S  +S         P       PP PPP     P P + K    P  K        T TP
Sbjct: 2398 SLDISAQPPPPPPPPPPPPPPPPPPPPP---PLPPPTSPKPTILPKKKLTVASPVTTATP 2454

Query: 671  PGYRGTSPPAGPGTFKPGSP-----TVGPGPLPP---AGPSGL-----PSLPPPPAAPAS 717
                 T+          G P     T  P P+PP   + PSGL     P    PP AP  
Sbjct: 2455 LFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKP 2514

Query: 718  GPPLSATQIKQEPAEEYETPE----------SPVPPARSPSPPPKVVDVPSHASQSARFN 767
              P   T   Q+P + +  P           + V  A    P P     P     S RF+
Sbjct: 2515 VIPQLPT-TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFS 2573

Query: 768  KHL 770
            K L
Sbjct: 2574 KSL 2576



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 66/271 (24%), Positives = 82/271 (30%), Gaps = 60/271 (22%)

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
            P+  S SL      PP P   PPP          P  PP S                  P
Sbjct: 2392 PFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTS------------------P 2433

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYK-----TASPPGPPPYGKRA 643
             P+  P+       PV T T     ++T+  T      G       T +PP  PP     
Sbjct: 2434 KPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI 2493

Query: 644  PSPGAYKTATPPGYKPGSP----PSFRTGT---------PPGYRGTSPP----AGPGTFK 686
            PS   +     P   P +P    P   T T         P G   TS           +K
Sbjct: 2494 PSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYK 2553

Query: 687  PGSPTVGPGPLPPAGPSGLP-------------SLPPPPAAPASGPPLSATQ-IKQEPAE 732
              SPT    PL P      P             +LP  P  P      SA+Q I   P  
Sbjct: 2554 LPSPT---SPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDS---SASQAITSWPLG 2607

Query: 733  EYETPESPVPPARSPSPPPKVVDVPSHASQS 763
                    V P  S  PP   V++P  + Q+
Sbjct: 2608 SPSKDLVSVEPVFSVVPPVTAVEIPISSEQT 2638



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 85/423 (20%), Positives = 140/423 (33%), Gaps = 54/423 (12%)

Query: 361  PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS-------------PFPASQALPS 407
            P+ S+   PP   P  +SS SS   + SSS  ++  S              F  S+ + S
Sbjct: 2169 PSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISS 2228

Query: 408  ---YPHS---FPPPTSLSVSNQPPKYTQPS----------LPSQAVWSQGPPPPPPYGRL 451
               +P S   +P   S+S+    P   + S          + S  + S  P P  P    
Sbjct: 2229 STYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSIIESVVPKPEGPVADT 2288

Query: 452  LANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP 511
            ++         P     + T +  +      ++ +++ + ++ +    +         PP
Sbjct: 2289 VSTDLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDH----PP 2344

Query: 512  PGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSS 571
                  P++   S     +    + G  +P     + LP     VS   A P  P   SS
Sbjct: 2345 SSVIALPMKEQLS--TTYFTSGETFGQEKP----ASQLPSGSPSVSSLPAKPR-PFFRSS 2397

Query: 572  SNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPP--VPTVTTSSATLSTVIATVASSPAGYK 629
            S   S+      P   P P   P   P P PP   P  T       TV + V ++   + 
Sbjct: 2398 SLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFD 2457

Query: 630  TASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGS 689
              +        +    P      T P   P  P S     P G   T  P      +P  
Sbjct: 2458 AVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI----PSGLVFTHRP------EPSK 2507

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYE--TPESPVPPARSP 747
            P + P P+ P  P+           P      S+  +    + +Y+  +P SP+ P  + 
Sbjct: 2508 PPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNK 2567

Query: 748  SPP 750
            S P
Sbjct: 2568 SSP 2570



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 68/299 (22%), Positives = 108/299 (36%), Gaps = 53/299 (17%)

Query: 632  SPPGPPP--YGKRAP-SPG-AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKP 687
            SPP  P   Y   +P SPG A ++A  P  KP                  PPA P T K 
Sbjct: 3615 SPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKM 3674

Query: 688  GSPTVG-PGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARS 746
               ++  P PL P             A  +S  P   T+       +  T        + 
Sbjct: 3675 MQRSMSDPKPLSPT------------ADESSRAPFQYTEGYTTKGSQTMTSSGAQKKVKR 3722

Query: 747  --PSPPPKVVDVPSHASQSARFNKHLDR--GFNSCARS--------DLYFVPLEGSKLAK 794
              P+PPP+ +   + ++ S        R    N+ AR+        +L  V  E +KL K
Sbjct: 3723 TLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRK 3782

Query: 795  KRADLVEKV----------------RREAEQRAREEKEREREREREKEREREKERELERS 838
            K+A+L E+                 R+EA  + RE++ER   +   ++R+   + E+  +
Sbjct: 3783 KQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSST 3842

Query: 839  VKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSP 897
                 E +  +E P   P      F        +PP    ++  +   S Y +    SP
Sbjct: 3843 RPTRIESQHGIERPRTAPQTEFSQF--------IPPQTQTESQLVPPTSPYTQYQYSSP 3893



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 23/136 (16%)

Query: 374  PYSSSSSSSAAASSSS-----------SSSSSSASPFPASQALP-SYPHSFPP----PTS 417
            PYSS S S  ++  SS           SSSSS       ++AL  S+ H+       PTS
Sbjct: 4282 PYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSARTKPTS 4341

Query: 418  LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVS 477
            L +S      ++  +P  A  S+   P  P G+ +  + A  GP PP +    T     S
Sbjct: 4342 LPISQ-----SRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISA--DTRDQFGS 4394

Query: 478  THHHHHQQQQQQQQQQ 493
            +H     QQ  +++ +
Sbjct: 4395 SHSLPEVQQHMREESR 4410



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 2/102 (1%)

Query: 48   EKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDS 107
            EK         V+E   P+   +G      +S  +E +  K TKT +E P+P   +  D 
Sbjct: 1274 EKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDD--KTTKTIKEQPQPPCTAKPDQ 1331

Query: 108  LDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSS 149
            ++      +   D  D     +  SP   S     +D  SSS
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 33/121 (27%), Positives = 47/121 (38%), Gaps = 19/121 (15%)

Query: 360  PPASSSAPAPPMRFPYSS---SSSSSAAASSSSSSSS---SSASPFPASQALPS--YPHS 411
            PP     P P +   YSS   + S+   A S   S     S  SP    +AL S   P+ 
Sbjct: 3586 PPKDKKRPTP-LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644

Query: 412  FPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQST 471
             P P  +S    P K   P +      ++ PP  P   +++  S + P P  P+    S 
Sbjct: 3645 KPLPDDIS----PQKVLHPDM------AKVPPASPKTAKMMQRSMSDPKPLSPTADESSR 3694

Query: 472  A 472
            A
Sbjct: 3695 A 3695



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 38/166 (22%), Positives = 59/166 (35%), Gaps = 19/166 (11%)

Query: 822 EREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPF-EPGSAVATVPPYLGPDT 880
           +R+  R + K+ ++ R   +     +P + P   P P +PP  +PG   +   P   P  
Sbjct: 275 QRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQ 334

Query: 881 PALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARER 940
           P     S   +P    PG    P   P         G   P      PA    ++   E+
Sbjct: 335 P-----SGLTKPLAQQPGTVKPPVQPP---------GTTKPPAQPLGPAKPPAQQTGSEK 380

Query: 941 DLRDRLKPGFEVKPSELEPLHG-VPGPGLDPFPRHG---GLALQPG 982
              ++  P    +P  +       PGP   P  + G    LA QPG
Sbjct: 381 PSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426


>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 [Homo
            sapiens]
          Length = 2231

 Score =  107 bits (268), Expect = 5e-23
 Identities = 167/687 (24%), Positives = 228/687 (33%), Gaps = 128/687 (18%)

Query: 152  SQGPARP-YHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP 210
            S G + P Y  P   PP P  P S      A+     +    G    M    +    A  
Sbjct: 374  SYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWA 433

Query: 211  GAPP-PHPQLYPGGTG---GVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSG 266
             A    HP + PG  G   G   G PM P         G  +     P  ++P    S G
Sbjct: 434  AAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYG 493

Query: 267  ASGAPPTKPPTTPVG-GGNLPSAPPPANFPHVTPNLPPPPALRPLNN--ASASPPGLGAQ 323
              G     P   P+G  G  P A     +P     +PP    + ++        P    Q
Sbjct: 494  PPG-----PQRYPIGIQGRTPGAMAGMQYPQ--QQMPPQYGQQGVSGYCQQGQQPYYSQQ 546

Query: 324  PLPGHLPSPHAM------------GQGMGGLPPGPEKGPTLAPS--------------PH 357
            P P HLP P A              Q M     G    P LAP               P 
Sbjct: 547  PQPPHLP-PQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS 605

Query: 358  SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
            SLP  S S    P     + SS+ SA+ S+SS    S+ +  P S      PH+ P  +S
Sbjct: 606  SLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS------PHASPHLSS 659

Query: 418  LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPST--GAQSTAHPP 475
            +                      G P P P G  + ++ +  GP  P++  G+Q    PP
Sbjct: 660  IP---------------------GGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPP 698

Query: 476  ----VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP--PGAFPHPLEGGSSHHA-H 528
                 S+ H    Q    Q++      Q+       GP    P   PHP  GG  H    
Sbjct: 699  GSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGIS 758

Query: 529  PYAMSPSLGSLRPY-----PPGPAHLPPPHSQV-SYSQAGPNGPPVSSSSNSSSSTSQGS 582
             +  S S G+  P      P G    PP +S V S S +GP GP +  S+N+       S
Sbjct: 759  SFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGP-GPGMGISANNQMHGQGPS 817

Query: 583  YPC-------------------------SHPSPSQGPQGAPYPFPPVPTVTTSSATLSTV 617
             PC                         +  SP    QG P   PP+PTV   +   +  
Sbjct: 818  QPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAA 877

Query: 618  IATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS 677
            +   A++ A  +  S PG    G  A S             P S P   + +    +   
Sbjct: 878  VMQAAANSAQSRQGSFPGMNQSGLMASS------------SPYSQPMNNSSSLMNTQAPP 925

Query: 678  PPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETP 737
                P      + +VG   +   G S LP LP        G P    Q + +  + Y + 
Sbjct: 926  YSMAPAMVNSSAASVGLADMMSPGESKLP-LPLKADGKEEGTP----QPESKSKDSYSSQ 980

Query: 738  ESPVPPARSPSPPPKVVDVPSHASQSA 764
                PP     P P  +  PS AS S+
Sbjct: 981  GISQPPTPGNLPVPSPMS-PSSASISS 1006



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 156/668 (23%), Positives = 200/668 (29%), Gaps = 112/668 (16%)

Query: 146 DSSSGLSQGPARPYHPPPLFPPSPQPPDSTPR--QPEASFEPHPSVTPTGYHAPMEPPTS 203
           DS++G   G A P  PP L  P  +  D+ P+  +P      HP +   G   P      
Sbjct: 106 DSAAG---GQADPPGPPLLSKPGDED-DAPPKMGEPAGGRYEHPGLGALGTQQP------ 155

Query: 204 RMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG---------GKQHP 254
                        P   PGG GG  + P      G AA + GGP G         G Q  
Sbjct: 156 -------------PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQS 202

Query: 255 PPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPA-------- 306
           P    +  +S+ A+GAP +  P       N     P +   H  P    P A        
Sbjct: 203 PGMGMMHSASAAAAGAPGSMDPLQ-----NSHEGYPNSQCNHY-PGYSRPGAGGGGGGGG 256

Query: 307 --------LRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS 358
                         A A   G GA        +  A G G GG   G   G  +  SP  
Sbjct: 257 GGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGY-GGSSAGYGVLSSPRQ 315

Query: 359 LPPASSSAPAPPMRFPYSSSSSSSAAAS----SSSSSSSSSASPFPASQALPSYPHSFPP 414
                   P        S +++ SAA      +  +   S A+P   +Q L S     P 
Sbjct: 316 QGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATP-TLNQLLTS-----PS 369

Query: 415 PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGP-------FPPSTG 467
           P   S     P+Y+ PS P        PPP  P  +  A   A  G             G
Sbjct: 370 PMMRSYGGSYPEYSSPSAPP-------PPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 422

Query: 468 AQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP-LEG-GSSH 525
           AQ  A  P          QQ+                    P  P     P L G GS+ 
Sbjct: 423 AQYAAASPAWA-----AAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNP 477

Query: 526 HAHPYAMSPSLGSLRPYPPGPAHLP------PPHSQVSYSQAGPNGPPVSSSSNSSSSTS 579
           H+ P   SP  G     PPGP   P       P +           PP       S    
Sbjct: 478 HSQPQQSSPYPGGSYG-PPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQ 536

Query: 580 QGSYP--CSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637
           QG  P     P P   P  A Y           S +          S  GY T S P   
Sbjct: 537 QGQQPYYSQQPQPPHLPPQAQY---------LPSQSQQRYQPQQDMSQEGYGTRSQPPLA 587

Query: 638 PYGKRAPSPGAYKTATPPGYK--PGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPG 695
           P           +   P       GS     TGT          +G  + +         
Sbjct: 588 PGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQS 647

Query: 696 PLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVD 755
           P  P     L S+P  P+    G P+ + Q +  P      P S +P    P PP    +
Sbjct: 648 PFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMP----PQPPGSQSE 703

Query: 756 VPSHASQS 763
             SH + S
Sbjct: 704 SSSHPALS 711



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 144/602 (23%), Positives = 196/602 (32%), Gaps = 97/602 (16%)

Query: 222 GGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPV- 280
           GG GG   G   G  GGG  +  GG   G          + +  G  G          V 
Sbjct: 251 GGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVL 310

Query: 281 -----GGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHLPSPHA 334
                 GG +   P       ++       A      A  +    GA P L   L SP  
Sbjct: 311 SSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSP 370

Query: 335 MGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAP---------------APPMRFPYSSSS 379
           M +  GG  P     P+  P P S P + ++A                   M   Y+++S
Sbjct: 371 MMRSYGGSYP-EYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAAS 429

Query: 380 SSSAAASSSSSSSSSSASPFPA---SQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQA 436
            + AAA   S  + S  +P P    SQ  P  P     P    + + P    Q S P   
Sbjct: 430 PAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPG 489

Query: 437 VWSQGPPPPPPY-----GR---LLANSNAHPGPFPPSTGAQSTA---------------H 473
             S GPP P  Y     GR    +A         PP  G Q  +                
Sbjct: 490 -GSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQ 548

Query: 474 PPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMS 533
           PP       +   Q QQ+ Q QQ   Q+ +   S PP     P+  +        P ++ 
Sbjct: 549 PPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP 608

Query: 534 PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP-SPSQ 592
              GS+   P G        ++ + S A        S+S S+SS    S P   P SP  
Sbjct: 609 DLSGSIDDLPTG--------TEATLSSA-------VSASGSTSSQGDQSNPAQSPFSPHA 653

Query: 593 GPQ-----GAPYPFP---PVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP 644
            P      G P P P   PV +  + S  +S      AS P       PPG        P
Sbjct: 654 SPHLSSIPGGPSPSPVGSPVGSNQSRSGPISP-----ASIPGSQMPPQPPGSQSESSSHP 708

Query: 645 SPGAYKTATPPGYKPG---SPPSFRTGTPPGYRGTSPPAGPG--------TFKPGSPTVG 693
           +          G+  G   +P   + G        SP   PG        +F+  + +  
Sbjct: 709 ALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGT 768

Query: 694 PGP-LPPAGPSGLPSLPPP----PAAPAS--GPPLSATQIKQEPAEEYETPESPVPPARS 746
            GP +   GP G  S PP     P+A  S  GP +  +   Q   +    P   VP  R 
Sbjct: 769 YGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRM 828

Query: 747 PS 748
           PS
Sbjct: 829 PS 830



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 188/849 (22%), Positives = 278/849 (32%), Gaps = 186/849 (21%)

Query: 6    NKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTP 65
            N  SM+  S    +  GP       G   P  V+  + +  A   +  A  A+  + S P
Sbjct: 841  NMSSMTPSSPGMSQQGGP-----GMGPPMPT-VNRKAQEAAAAVMQAAANSAQSRQGSFP 894

Query: 66   KVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGR-----SLNDDGSSD 120
             +N+ G     S   S+  N        Q  P   +P+ ++S          ++   S  
Sbjct: 895  GMNQSGLMAS-SSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKL 953

Query: 121  PRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDS------ 174
            P  +  D +        P S   DS SS G+SQ P     P  L  PSP  P S      
Sbjct: 954  PLPLKADGKEEGTP--QPESKSKDSYSSQGISQPPT----PGNLPVPSPMSPSSASISSF 1007

Query: 175  ---------------TPRQPEASFEPHPSVTPTG------YHAPMEPPTSRM------FQ 207
                           TP  P++S     S T TG      Y    EP           F 
Sbjct: 1008 HGDESDSISSPGWPKTPSSPKSS-----SSTTTGEKITKVYELGNEPERKLWVDRYLTFM 1062

Query: 208  APPGAPPPHPQLYPGGTGGVLSGPPMGPKGGG------AASSVGG---PNGGKQHPPPTT 258
               G+P             V S P +G K             +GG    N  K+     T
Sbjct: 1063 EERGSP-------------VSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELAT 1109

Query: 259  PISVSSSGASGAPPTKPPTTPVGGGNLP----SAPPPANFPHVTPNLPPPPALRPLNNAS 314
             ++V +S ++ +   K     +            PPP  F   T +    P L+P     
Sbjct: 1110 NLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFS--TGDTKKQPKLQP----- 1162

Query: 315  ASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS--LPPASSSAPAPPMR 372
             SP   G+   P    +P + G       PG  K PT A +PH    P     +    + 
Sbjct: 1163 PSPANSGSLQGP---QTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVH 1219

Query: 373  FPYSSSSSSSAAASSSSSSSSS------------------SASPFPASQALPSYPHSFPP 414
             P+S  S SS    +S + ++                   +  PF   + +P     F  
Sbjct: 1220 DPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMT 1279

Query: 415  PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYG-----RLLANSNAHPGPFPPST--- 466
               +  S+    Y Q    + +    G     PYG     R       +PG  PPS    
Sbjct: 1280 QGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPP 1339

Query: 467  --GAQSTAHPPVSTHHHH-----------HQQQQQQQQQQQQQQQQQQQHHGN-SGP--- 509
              G Q   +P    +  H           H+      Q   QQQ+   Q+ G+ SGP   
Sbjct: 1340 YGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRR 1399

Query: 510  PPPGAFPHP-----LEGGSSHHAH---------PYAMSPSLGSLRPYPPGPAHLPPPHSQ 555
            P  G +P+P     ++G      H         P   S S G  +        +P P+  
Sbjct: 1400 PIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQ- 1458

Query: 556  VSYSQAGPNGP---PVSSSSNSSSSTSQGSYPCSHPS--PSQGPQGAPYPFPPVPTVTTS 610
               ++ GP GP   P     N +          +H S  PS   Q  PY         +S
Sbjct: 1459 ---NRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPY--------MSS 1507

Query: 611  SATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTP 670
            SA++  +     + P      +PP  P +  RAPSP +++ +      P   P   +   
Sbjct: 1508 SASMQPI-----TRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKM 1562

Query: 671  PGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEP 730
                 T P          S   GP P PP  P       PP +  AS P L   Q ++  
Sbjct: 1563 QKVMPTVPT---------SQVTGPPPQPP--PIRREITFPPGSVEASQPVLK--QRRKIT 1609

Query: 731  AEEYETPES 739
            +++  TPE+
Sbjct: 1610 SKDIVTPEA 1618



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 74/277 (26%), Positives = 94/277 (33%), Gaps = 60/277 (21%)

Query: 460 GPFPPSTGAQSTAHPPVSTHHHHHQ----------------QQQQQQQQQQQQQQQQQQH 503
           G  P +   Q   H   + HHHHH                 QQQQQQQQQQQQQQQQQQH
Sbjct: 15  GEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQH 74

Query: 504 HGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGP 563
             ++     GA      GG +    P    P  G  +    G              QA P
Sbjct: 75  PISNNNSLGGA------GGGAPQPGPDMEQPQHGGAKDSAAG-------------GQADP 115

Query: 564 NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTV-----I 618
            GPP+ S                 P     P G  Y  P +  + T    ++        
Sbjct: 116 PGPPLLSKPGDEDDA---------PPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGP 166

Query: 619 ATVASSPAGYKTASPPGPPPYGKRAP---------SPGAYKTATPPGYKPGSPPSF--RT 667
           A V      Y +A+P    P G+  P         SPG     +      G+P S     
Sbjct: 167 AAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQ 226

Query: 668 GTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSG 704
            +  GY  +     PG  +PG+   G G     G SG
Sbjct: 227 NSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSG 263



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 160/726 (22%), Positives = 241/726 (33%), Gaps = 150/726 (20%)

Query: 77   SESESEETN------APKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRS 130
            + S+ +++N      +P  +     +P   SPS + S  G + +  G   P  I      
Sbjct: 635  TSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMP 694

Query: 131  TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPP--SPQPPDSTPRQPEASFEPHPS 188
              P    PGS +++S S   LSQ P  P     +     +PQ     P+Q   S  PHPS
Sbjct: 695  PQP----PGS-QSESSSHPALSQSPM-PQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPS 748

Query: 189  V---TPTGYHAPMEPPTS-----RMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGP----- 235
                   G  +  +  +S     +M Q  P      P  Y G      SGP  G      
Sbjct: 749  PGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISAN 808

Query: 236  ---KGGGAASSVGG------PNGGKQHPP---PTTPISVSSSGAS--GAPPTKPPTTPVG 281
                G G +   G       P+ G Q+ P     + ++ SS G S  G P   PP   V 
Sbjct: 809  NQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVN 868

Query: 282  ----------------------------------GGNLPSAPPPANFPHVTPNLPPPPAL 307
                                                + P + P  N   +     PP ++
Sbjct: 869  RKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSM 928

Query: 308  RP-LNNASASPPGLGAQPLPGH--LPSP-HAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363
             P + N+SA+  GL     PG   LP P  A G+  G   P  +   + +    S PP  
Sbjct: 929  APAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTP 988

Query: 364  SSAPAPPMRFPYSSSSSSSAAASSSS----------SSSSSSASPFPASQALPSYPHSFP 413
             + P P    P S+S SS     S S          SS  SS+S     +    Y     
Sbjct: 989  GNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNE 1048

Query: 414  PPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPY----------GRLLANSNAHPGPFP 463
            P   L V        +   P  ++ + G  P   +          G    N N       
Sbjct: 1049 PERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELA 1108

Query: 464  P--STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEG 521
               + G  S+A   +   +  +    + + ++ ++   +    G++   P    P P   
Sbjct: 1109 TNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANS 1168

Query: 522  GS------SHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNG-----PPVSS 570
            GS             +M+   G L+  PP PA    PH Q++  Q G +       P S 
Sbjct: 1169 GSLQGPQTPQSTGSNSMAEVPGDLK--PPTPA--STPHGQMTPMQGGRSSTISVHDPFSD 1224

Query: 571  SSNSS-----SSTSQGSYP--CSHP--------SPSQGPQGA--PYPFPPVPTVTTSSAT 613
             S+SS     S T    Y    S P         P++ P G     P    P +T     
Sbjct: 1225 VSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMP 1284

Query: 614  LSTVIATVASSPAG--------------YKTASPPGPPPYGKRAPSPGAYKTATPP--GY 657
             S++      SP+G              Y  +      PYG++ P  G   +  PP  G+
Sbjct: 1285 NSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGP-PSGQPPYGGH 1343

Query: 658  KPGSPP 663
            +PG  P
Sbjct: 1344 QPGLYP 1349


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score =  102 bits (254), Expect = 2e-21
 Identities = 179/729 (24%), Positives = 232/729 (31%), Gaps = 109/729 (14%)

Query: 97   PRPQSPSDLDSLDGRSLNDDG-SSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGP 155
            P PQ P+         L   G SS P    Q     SP + SP      S   S   Q  
Sbjct: 758  PAPQIPA------AAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSR-PQSV 810

Query: 156  ARPYHPPPLFP-PSPQPPDSTPR----QPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP 210
            +RP   PPL P P PQ P + P     Q +    P  S        P +PP     Q P 
Sbjct: 811  SRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPE 870

Query: 211  GAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA 270
            G  PP P L P  T                +S+V   +      P  TP           
Sbjct: 871  GPLPPAPHLPPSST----------------SSAVASSSETSSRLPAPTPSDFQLQFPPSQ 914

Query: 271  PPTKPPTTP-----VGGGNLPSAPPPANFPHVT---PNLPPPPALRP-----------LN 311
             P K PT P     V     P  PPP  F  VT   P LP P AL              N
Sbjct: 915  GPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQN 974

Query: 312  NASASPPGLGAQPLPGHLPSPHA----MGQGMGGLPPGPEKGPTLAP-SPHSLPP----- 361
             A  +P         G L SP A     GQ   G P  P   P  AP +   LPP     
Sbjct: 975  KAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAE 1034

Query: 362  ---------------ASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSS----SASPFPAS 402
                           A+SS P  P    Y S  S      +   S  +           S
Sbjct: 1035 NKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGS 1094

Query: 403  QALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYG-RLLANSNAHPGP 461
               P Y  +FP          P    Q +LPS + + +          +LL  + A    
Sbjct: 1095 VLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNK 1154

Query: 462  FPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEG 521
            +      +S    P +      +   Q+++      +Q  +   +       +   P+  
Sbjct: 1155 YRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLPIAA 1214

Query: 522  GSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPH--SQVSYSQAGPNGPPVSSSSNSSSSTS 579
             S  H       P  G L    PG +  PPPH  +++     G  G P  + + +SSS S
Sbjct: 1215 SSEGH-----RLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLS 1269

Query: 580  QGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGY-KTASPPGPPP 638
              S   S  S     +  P P    P + T  A     +       AG  K        P
Sbjct: 1270 SSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDP 1329

Query: 639  YGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGP-----GTFKPGSPTV- 692
              +  P P   K A PP   P  PP   TG   G     PPA P     GT  P  P + 
Sbjct: 1330 VHQPPPPPATLKVAEPPPRPPPPPPP--TGQMNGTVDHPPPAAPERKPLGT-APHCPRLP 1386

Query: 693  ----------GPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVP 742
                      GPG  P   P+G      P   PA     ++  I++  A E E  +  + 
Sbjct: 1387 LRKTYRENVGGPG-APEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRML- 1444

Query: 743  PARSPSPPP 751
              + P P P
Sbjct: 1445 --KGPPPEP 1451



 Score =  100 bits (250), Expect = 6e-21
 Identities = 151/572 (26%), Positives = 190/572 (33%), Gaps = 134/572 (23%)

Query: 196  APMEPPTSRMFQAP----PGAPPPHPQLYPGGTGG--VLSGPPMGPKGGGAASSVGGPNG 249
            AP++     +FQ P     G+ P   Q  P G     VL G  + P    A + +  P+G
Sbjct: 545  APIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPS---AVAMLNTPDG 601

Query: 250  GKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRP 309
              Q   P TP + +   A        P  P      P+   P       P    PP   P
Sbjct: 602  LVQ---PATPAAATGEAAPVLTVQPAPQAP------PAVSTPLPLGLQQPQAQQPPQA-P 651

Query: 310  LNNASASPPGLGAQPLPGHLPSPH--AMGQGMGG--------------LPPGPEKGPTLA 353
               A+A P     QP PG   SP    +GQ                  LP    + P  A
Sbjct: 652  TPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSA 711

Query: 354  PSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFP 413
              PH   PAS    APP     + ++  +  A     +  S ASP PA Q   + P   P
Sbjct: 712  EGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGP 771

Query: 414  PPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAH 473
             P+S            PSLP QA     P  P P+          P   PPS   QS + 
Sbjct: 772  GPSS-----------SPSLPHQAPLGDSPHLPSPH-------PTRPPSRPPSR-PQSVSR 812

Query: 474  PPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMS 533
            PP     H     Q           Q Q      G PPP + P P   G           
Sbjct: 813  PPSEPPLHPCPPPQAPPTLPGIFVIQNQ-----LGVPPPASNPAPTAPGPPQPPLRPQSQ 867

Query: 534  PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPS---- 589
            P  G   P PP P HLPP                 +SS+ +SSS +    P   PS    
Sbjct: 868  PPEG---PLPPAP-HLPPSS---------------TSSAVASSSETSSRLPAPTPSDFQL 908

Query: 590  ---PSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSP 646
               PSQGP  +P P P +  V                         P  PPP     P P
Sbjct: 909  QFPPSQGPHKSPTPPPTLHLV-----------------------PEPAAPPP-----PPP 940

Query: 647  GAYKTATPPGYKPGSPPSFRT---GTPPGY----RGTSPPAGPGTFKPGSPTVGPGPLPP 699
              ++  T P      P +        P G     +    PA P T    S ++GP   P 
Sbjct: 941  RTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQT----STSLGPLTSPA 996

Query: 700  A-------GPSGLPSLPPPPAAPASGPPLSAT 724
            A        PSG P+ P    APA   P++AT
Sbjct: 997  ASVLVSGQAPSGTPTAPSHAPAPA---PMAAT 1025



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 165/684 (24%), Positives = 233/684 (34%), Gaps = 150/684 (21%)

Query: 163 PLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPG 222
           P   PS QP    P    +   P P+V       P++P        P G  PP  +LY  
Sbjct: 316 PTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPK-------PAGVLPP--KLYQ- 365

Query: 223 GTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASG---------APPT 273
                L+  P  P  G   +  G P    Q P     ++  ++G +G         AP  
Sbjct: 366 -----LTPKPFAP-AGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPAL 419

Query: 274 K------PPTTPVGGGNLPSAPPPA------------------NFPHVTPN-----LPPP 304
           +      PP T  G    P  PP A                     H+ P      LP  
Sbjct: 420 QANVFKQPPATTTGAA--PPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGA 477

Query: 305 PALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG-------LPPGPEKGPTLAPSPH 357
           PA++     SA P  +G Q L     +PH  GQ +         L      GP LAP  H
Sbjct: 478 PAVQLPQQLSALPANVGGQILAA--AAPHTGGQLIANPILTNQNLAGPLSLGPVLAP--H 533

Query: 358 SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFP-PPT 416
           S   ++    A P++      +      S ++ S  + + P PA  A  +       PP+
Sbjct: 534 SGAHSAHILSAAPIQV--GQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPS 591

Query: 417 SLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPV 476
           ++++ N P    QP+ P+ A     P                P P  P         P V
Sbjct: 592 AVAMLNTPDGLVQPATPAAATGEAAPV-----------LTVQPAPQAP---------PAV 631

Query: 477 STHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHH-----AHPYA 531
           ST      QQ Q QQ  Q    Q       +  PP    P P  G +S         P +
Sbjct: 632 STPLPLGLQQPQAQQPPQAPTPQ-------AAAPPQATTPQPSPGLASSPEKIVLGQPPS 684

Query: 532 MSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPS 591
            +P+  ++         LP   SQ   S  GP+    +S   S+   +Q   P +  +  
Sbjct: 685 ATPT--AILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKG 742

Query: 592 QG-------PQGAPYPFPPVPTVT-------TSSATL--STVIATVASSPAGYKT---AS 632
            G        Q +P P P +P          +SS +L     +      P+ + T   + 
Sbjct: 743 AGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSR 802

Query: 633 PPGPPPYGKRAPSPGAYKTATPPGYKP------------GSPPSFRTGTPPGYRGTSPPA 680
           PP  P    R PS        PP   P            G PP      P       PP 
Sbjct: 803 PPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPL 862

Query: 681 GPGTFKPGSPTVGPGPLPPAGPSGLPSLPP--PPAAPASGPPLSATQIKQEPAE-EYETP 737
            P +  P       GPLPPA     P LPP    +A AS    S+      P++ + + P
Sbjct: 863 RPQSQPP------EGPLPPA-----PHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFP 911

Query: 738 ESPVPPARSPSPPPKVVDVPSHAS 761
            S   P +SP+PPP +  VP  A+
Sbjct: 912 PSQ-GPHKSPTPPPTLHLVPEPAA 934



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 98/344 (28%), Positives = 123/344 (35%), Gaps = 78/344 (22%)

Query: 153 QGPARPYHPPPLFPPSPQ--------------PPDSTPRQPEASFEPH---------PSV 189
           Q P     P PL    PQ              PP +T  QP                PS 
Sbjct: 626 QAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSA 685

Query: 190 TPTGYHAPMEPPTSRMF------QAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASS 243
           TPT   A +   + +MF      Q P  A  PH  + P     ++S PP       A   
Sbjct: 686 TPT---AILTQDSLQMFLPQERSQQPLSAEGPHLSV-PASV--IVSAPPPAQDPAPATPV 739

Query: 244 VGGPNGGKQHPPPTTPISVSSSGASGAP-PTKPPTTPVGGGNLPSAPPPANFPHV----- 297
             G   G Q P          S AS AP P  P   P+ G    S+P   + PH      
Sbjct: 740 AKGAGLGPQAP---------DSQASPAPAPQIPAAAPLKGPGPSSSP---SLPHQAPLGD 787

Query: 298 TPNLPPPPALRPLNNASASPPGLGAQP------------LPGHLPSPHAMGQGMGGLPPG 345
           +P+LP P   RP +   + P  +   P             P  LP    +   +G  PP 
Sbjct: 788 SPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPA 847

Query: 346 PEKGPTLAPSPHSLP--PASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQ 403
               PT AP P   P  P S     P    P+   SS+S+A +SSS +SS   +P P+  
Sbjct: 848 SNPAPT-APGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDF 906

Query: 404 ALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPP 447
            L      FPP      S  PP  T   +P  A     PPPPPP
Sbjct: 907 QL-----QFPPSQGPHKSPTPPP-TLHLVPEPA----APPPPPP 940



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 148/604 (24%), Positives = 202/604 (33%), Gaps = 119/604 (19%)

Query: 263 SSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPN-LPP------PPALRPLNNASA 315
           ++S  +G P  +P     G G+ P  P P    H TP  + P      PP L  L     
Sbjct: 312 AASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPF 371

Query: 316 SPPG--LGAQPLPGHLPSPHAMGQGMGGLPPGPE---------KGPTLAPSPHSLPPASS 364
           +P G  L  Q  PG LP      Q +  +  G             P L  +    PPA++
Sbjct: 372 APAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATT 431

Query: 365 SAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPP-------PTS 417
           +  APP   P + S   S    +  SS        PA   LP       P       P  
Sbjct: 432 TGAAPPQP-PGALSKPMSVHLLNQGSS-----IVIPAQHMLPGQNQFLLPGAPAVQLPQQ 485

Query: 418 LS-----VSNQPPKYTQPSLPSQAV-----WSQGPPPPPPYGRLLA-NSNAHPGPF---- 462
           LS     V  Q      P    Q +      +Q    P   G +LA +S AH        
Sbjct: 486 LSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSAA 545

Query: 463 PPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAF---PHPL 519
           P   G  +    PVS        Q Q            Q   G + PP   A    P  L
Sbjct: 546 PIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQ---GVTLPPSAVAMLNTPDGL 602

Query: 520 EGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPP---HSQVSYSQAGPNGPPVSSSSNSSS 576
              ++  A     +P L +++P P  P  +  P     Q   +Q  P  P   +++   +
Sbjct: 603 VQPATPAAATGEAAPVL-TVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQA 661

Query: 577 STSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSAT------------------LSTVI 618
           +T Q S P    SP +   G P    P   +T  S                    LS   
Sbjct: 662 TTPQPS-PGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPA 720

Query: 619 ATVASSPAGYKTASPPGP----------PPYGKRAPSPGAYKTATPP--GYKPGSPPSFR 666
           + + S+P   +  +P  P           P  + +P+P     A  P  G  P S PS  
Sbjct: 721 SVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLP 780

Query: 667 TGTP-------PGYRGTSPPAGPG------TFKPGSPTVGPGPLPPAGPSGLPSL----- 708
              P       P    T PP+ P       +  P  P + P P PP  P  LP +     
Sbjct: 781 HQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCP-PPQAPPTLPGIFVIQN 839

Query: 709 ----PPP---PAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHAS 761
               PPP   PA  A GPP    + + +P      PE P+PPA    P      V S + 
Sbjct: 840 QLGVPPPASNPAPTAPGPPQPPLRPQSQP------PEGPLPPAPHLPPSSTSSAVASSSE 893

Query: 762 QSAR 765
            S+R
Sbjct: 894 TSSR 897



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 115/441 (26%), Positives = 153/441 (34%), Gaps = 74/441 (16%)

Query: 34   SPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEET---NAPKKT 90
            +P  VST    G  +   Q   +A   +A+ P      +      S  E+      P  T
Sbjct: 627  APPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSAT 686

Query: 91   KT--------EQELPRPQSPSDLDSLDGRSLNDDGS---SDPRDIDQDNRSTSPSIYSPG 139
             T        +  LP+ +S   L S +G  L+   S   S P    QD    +P     G
Sbjct: 687  PTAILTQDSLQMFLPQERSQQPL-SAEGPHLSVPASVIVSAPPPA-QDPAPATPVAKGAG 744

Query: 140  SVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPH-PSVTPTGYHAPM 198
                  DS +  +  P  P    PL  P P    S P Q      PH PS  PT    P 
Sbjct: 745  LGPQAPDSQASPAPAPQIPA-AAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPT--RPPS 801

Query: 199  EPPT-----SRMFQAPPGAPPPHPQLYPGGTG-----GVLSGPPMGPKGGGAASSVGGPN 248
             PP+     SR    PP  P P PQ  P   G       L  PP  P    A ++ G P 
Sbjct: 802  RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPP--PASNPAPTAPGPPQ 859

Query: 249  G----------GKQHPPPTTPISVSSSGASGAPPTK---PPTTPVGGGNLPSAPPPANFP 295
                       G   P P  P S +SS  + +  T    P  TP    +     PP+  P
Sbjct: 860  PPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTP---SDFQLQFPPSQGP 916

Query: 296  HVTPNLPPPPALRPLNNASASPPG------LGAQPLPGHLPSPHAMGQGMGGLPPGPEKG 349
            H +P   PPP L  +   +A PP       +   P P  LP P A+ +    +P G    
Sbjct: 917  HKSPT--PPPTLHLVPEPAAPPPPPPRTFQMVTTPFPA-LPQPKALLERFHQVPSGI--- 970

Query: 350  PTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAA------SSSSSSSSSSASPFPASQ 403
                     L   +  APA P         +S AA+      + S + ++ S +P PA  
Sbjct: 971  --------ILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPM 1022

Query: 404  ALPSYPHSFPPPTSLSVSNQP 424
            A    P   P       SN P
Sbjct: 1023 AATGLPPLLPAENKAFASNLP 1043



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 84/374 (22%), Positives = 125/374 (33%), Gaps = 69/374 (18%)

Query: 314  SASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRF 373
            S+S PG   QP P HLP+   +  G  G  P             S+  A +S        
Sbjct: 1228 SSSAPGASTQP-PPHLPTKLVIRHGGAGGSP-------------SVTWARAS-------- 1265

Query: 374  PYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLP 433
              SS SSSS+++S++SS  +    P P+    P   +       L +  +        + 
Sbjct: 1266 --SSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVH 1323

Query: 434  SQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQ--STAHPPVSTHHHHHQQQQQQQQ 491
            + A+     PPPPP    +A     P P PP TG    +  HPP +      +++     
Sbjct: 1324 NTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAA----PERKPLGTA 1379

Query: 492  QQQQQQQQQQQHHGNSGPP--PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHL 549
                +   ++ +  N G P  P G       GGS           + G +R        L
Sbjct: 1380 PHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDEL 1439

Query: 550  -------PPPHSQVSYSQA-------GPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQ 595
                   PPP    S +Q         P  PP     + S    Q S+    P       
Sbjct: 1440 YQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDD---- 1495

Query: 596  GAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPP 655
                             TL+  + +   S    + A    P P    A S G    + PP
Sbjct: 1496 -----------------TLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGT-PASPPP 1537

Query: 656  GYKPGS-PPSFRTG 668
             ++P + PPS   G
Sbjct: 1538 LHRPEAYPPSSHNG 1551



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 71/287 (24%), Positives = 95/287 (33%), Gaps = 45/287 (15%)

Query: 112  SLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLS------QGPARPYHPPPLF 165
            S +   SS    +D D     PS   P     ++ S  GL        G ++  H   L 
Sbjct: 1269 SSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALD 1328

Query: 166  PP-SPQPPDSTPRQPEASFEPHPSVTPTGYHAPM--EPPTSRMFQAPPGAPPPHPQLYPG 222
            P   P PP +T +  E    P P   PTG        PP +   + P G  P  P+L   
Sbjct: 1329 PVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLR 1388

Query: 223  GTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGA--------------- 267
             T     G P  P+G  A    G   GG   P P   +  ++SG                
Sbjct: 1389 KTYRENVGGPGAPEGTPA----GRARGGSPAPLPAK-VDEATSGLIRELAAVEDELYQRM 1443

Query: 268  -SGAPPTKPPTTPVGGGN----LPSAPPPANFPHVTPNLP--------PPPALRPLNNAS 314
              G PP    +   G G+     P  PP       +P++         P       +  S
Sbjct: 1444 LKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQS 1503

Query: 315  ASPPGLGAQPLPGHLPSP---HAMGQGMGGLPPGPEKGPTLAPSPHS 358
            A    L  Q  PG  P+P   HA   G    PP   +     PS H+
Sbjct: 1504 AIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHN 1550



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 66/246 (26%), Positives = 82/246 (33%), Gaps = 45/246 (18%)

Query: 195  HAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254
            H P  PP +     PP  PPP P       G V   PP  P+          P G   H 
Sbjct: 1331 HQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPE--------RKPLGTAPHC 1382

Query: 255  P--PTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN 312
            P  P       + G  GAP   P     GG     AP PA     T  L        +  
Sbjct: 1383 PRLPLRKTYRENVGGPGAPEGTPAGRARGGS---PAPLPAKVDEATSGL--------IRE 1431

Query: 313  ASASPPGLGAQPLPGHLPSPHA-MGQGMG-------GLPPGPEKGPTLAPSPHSLPPASS 364
             +A    L  + L G  P P A   QG G       GLPP   +    + SP  +  AS 
Sbjct: 1432 LAAVEDELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRR---KSESP-DVDQASF 1487

Query: 365  SAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424
            S+ +P           +      S+  S  +    P     PSYPH+    T  S    P
Sbjct: 1488 SSDSP--------QDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPAS----P 1535

Query: 425  PKYTQP 430
            P   +P
Sbjct: 1536 PPLHRP 1541



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 99/415 (23%), Positives = 130/415 (31%), Gaps = 134/415 (32%)

Query: 357  HSLP---PASSSAPA----PPMRFPYS----------SSSSSSAAASSS---SSSSSSSA 396
            H LP   P SSSAP     PP   P            S S + A ASSS   SSSSSS+A
Sbjct: 1219 HRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSSAA 1278

Query: 397  SPFPASQALPSYPHSFPPPTSLSVSNQ---PPKYTQPSLPSQAVWSQGPPPPPPYGRLLA 453
            S   A +  P    + PP  +    ++     K  Q +  S+ V +    P         
Sbjct: 1279 SSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDP--------- 1329

Query: 454  NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
                H  P PP+T     A PP                                 PPPP 
Sbjct: 1330 ---VHQPPPPPAT--LKVAEPPPR-------------------------------PPPP- 1352

Query: 514  AFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQ--AGPNGPPVSSS 571
              P P    +    HP   +P    L   P    H P    + +Y +   GP  P  + +
Sbjct: 1353 --PPPTGQMNGTVDHPPPAAPERKPLGTAP----HCPRLPLRKTYRENVGGPGAPEGTPA 1406

Query: 572  SNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTA 631
              +                     G+P P P      TS      +I  +A+        
Sbjct: 1407 GRARG-------------------GSPAPLPAKVDEATSG-----LIRELAAVEDELYQR 1442

Query: 632  SPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPT 691
               GPPP    + + G   T  P    PG PP+ R       +  SP     +F   SP 
Sbjct: 1443 MLKGPPPEPAASAAQG---TGDPDWEAPGLPPAKRR------KSESPDVDQASFSSDSPQ 1493

Query: 692  VG-----------------------PGP-LPPAGPSGLPSLPPPPAAPASGPPLS 722
                                     P P  P A  +G P+ PPP   P + PP S
Sbjct: 1494 DDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSS 1548


>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3
           [Homo sapiens]
          Length = 2178

 Score =  102 bits (254), Expect = 2e-21
 Identities = 157/651 (24%), Positives = 215/651 (33%), Gaps = 123/651 (18%)

Query: 152 SQGPARP-YHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP 210
           S G + P Y  P   PP P  P S      A+     +    G    M    +    A  
Sbjct: 374 SYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWA 433

Query: 211 GAPP-PHPQLYPGGTG---GVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSG 266
            A    HP + PG  G   G   G PM P         G  +     P  ++P    S G
Sbjct: 434 AAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYG 493

Query: 267 ASGAPPTKPPTTPVG-GGNLPSAPPPANFPHVTPNLPPPPALRPLNN--ASASPPGLGAQ 323
             G     P   P+G  G  P A     +P     +PP    + ++        P    Q
Sbjct: 494 PPG-----PQRYPIGIQGRTPGAMAGMQYPQ--QQMPPQYGQQGVSGYCQQGQQPYYSQQ 546

Query: 324 PLPGHLPSPHAM------------GQGMGGLPPGPEKGPTLAPS--------------PH 357
           P P HLP P A              Q M     G    P LAP               P 
Sbjct: 547 PQPPHLP-PQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS 605

Query: 358 SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
           SLP  S S    P     + SS+ SA+ S+SS    S+ +  P S      PH+ P  +S
Sbjct: 606 SLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFS------PHASPHLSS 659

Query: 418 LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPST--GAQSTAHPP 475
           +                      G P P P G  + ++ +  GP  P++  G+Q    PP
Sbjct: 660 IP---------------------GGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPP 698

Query: 476 ----VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP--PGAFPHPLEGGSSHHA-H 528
                S+ H    Q    Q++      Q+       GP    P   PHP  GG  H    
Sbjct: 699 GSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGIS 758

Query: 529 PYAMSPSLGSLRPY-----PPGPAHLPPPHSQV-SYSQAGPNGPPVSSSSNSSSSTSQGS 582
            +  S S G+  P      P G    PP +S V S S +GP GP +  S+N+       S
Sbjct: 759 SFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGP-GPGMGISANNQMHGQGPS 817

Query: 583 YPC-------------------------SHPSPSQGPQGAPYPFPPVPTVTTSSATLSTV 617
            PC                         +  SP    QG P   PP+PTV   +   +  
Sbjct: 818 QPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAA 877

Query: 618 IATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS 677
           +   A++ A  +  S PG    G  A S             P S P   + +    +   
Sbjct: 878 VMQAAANSAQSRQGSFPGMNQSGLMASS------------SPYSQPMNNSSSLMNTQAPP 925

Query: 678 PPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQ 728
               P      + +VG   +   G S LP LP        G P   ++ K+
Sbjct: 926 YSMAPAMVNSSAASVGLADMMSPGESKLP-LPLKADGKEEGTPQPESKSKK 975



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 120/488 (24%), Positives = 171/488 (35%), Gaps = 91/488 (18%)

Query: 149 SGLSQGPARPYHP----PPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSR 204
           SG  Q   +PY+     PP  PP  Q     P Q +  ++P   ++  GY    +PP + 
Sbjct: 532 SGYCQQGQQPYYSQQPQPPHLPPQAQ---YLPSQSQQRYQPQQDMSQEGYGTRSQPPLA- 587

Query: 205 MFQAPPGAP---------PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG--GKQH 253
                PG P            P   P  +G +   P        +A S  G     G Q 
Sbjct: 588 -----PGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQS 642

Query: 254 PPPTTPISVSSS----GASGAPPTKPPTTPVGGGNLPSAP-PPANFPHVTPNLPPPPALR 308
            P  +P S  +S       G P   P  +PVG     S P  PA+ P     +PP P   
Sbjct: 643 NPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPG--SQMPPQPP-- 698

Query: 309 PLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAP-SPHSLPPASSSAP 367
              + S+S P L   P+P              G   G ++ P +A   P    P+ S  P
Sbjct: 699 GSQSESSSHPALSQSPMPQER-----------GFMAGTQRNPQMAQYGPQQTGPSMSPHP 747

Query: 368 APPMRFPYSSSSSSSAAASSSSSSSSSSASPF------PASQALPSYPHSFPPPTSLSVS 421
           +P  +     SS   + +S +     S   P       PA   +PS  +S P P     +
Sbjct: 748 SPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISA 807

Query: 422 NQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHH 481
           N       PS P  AV         P GR+  ++     PFP +  + + + P +S    
Sbjct: 808 NNQMHGQGPSQPCGAV---------PLGRM-PSAGMQNRPFPGNMSSMTPSSPGMSQQGG 857

Query: 482 HHQQQQQQQQQQQQQQQQQ--QQHHGNSGPPPPGAFP---------------HPLEGGSS 524
                      ++ Q+      Q   NS     G+FP                P+   SS
Sbjct: 858 PGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSS 917

Query: 525 ---HHAHPYAMSP--------SLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSN 573
                A PY+M+P        S+G      PG + LP P       +  P   P S S  
Sbjct: 918 LMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQ--PESKSKK 975

Query: 574 SSSSTSQG 581
           SSSST+ G
Sbjct: 976 SSSSTTTG 983



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 156/668 (23%), Positives = 200/668 (29%), Gaps = 112/668 (16%)

Query: 146 DSSSGLSQGPARPYHPPPLFPPSPQPPDSTPR--QPEASFEPHPSVTPTGYHAPMEPPTS 203
           DS++G   G A P  PP L  P  +  D+ P+  +P      HP +   G   P      
Sbjct: 106 DSAAG---GQADPPGPPLLSKPGDED-DAPPKMGEPAGGRYEHPGLGALGTQQP------ 155

Query: 204 RMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG---------GKQHP 254
                        P   PGG GG  + P      G AA + GGP G         G Q  
Sbjct: 156 -------------PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQS 202

Query: 255 PPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN-- 312
           P    +  +S+ A+GAP +  P       N     P +   H  P    P A        
Sbjct: 203 PGMGMMHSASAAAAGAPGSMDPLQ-----NSHEGYPNSQCNHY-PGYSRPGAGGGGGGGG 256

Query: 313 --------------ASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS 358
                         A A   G GA        +  A G G GG   G   G  +  SP  
Sbjct: 257 GGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYG-GSSAGYGVLSSPRQ 315

Query: 359 LPPASSSAPAPPMRFPYSSSSSSSAAAS----SSSSSSSSSASPFPASQALPSYPHSFPP 414
                   P        S +++ SAA      +  +   S A+P   +Q L S     P 
Sbjct: 316 QGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATP-TLNQLLTS-----PS 369

Query: 415 PTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGP-------FPPSTG 467
           P   S     P+Y+ PS P        PPP  P  +  A   A  G             G
Sbjct: 370 PMMRSYGGSYPEYSSPSAPP-------PPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMG 422

Query: 468 AQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP-LEG-GSSH 525
           AQ  A  P          QQ+                    P  P     P L G GS+ 
Sbjct: 423 AQYAAASPAWA-----AAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNP 477

Query: 526 HAHPYAMSPSLGSLRPYPPGPAHLP------PPHSQVSYSQAGPNGPPVSSSSNSSSSTS 579
           H+ P   SP  G     PPGP   P       P +           PP       S    
Sbjct: 478 HSQPQQSSPYPGGSYG-PPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQ 536

Query: 580 QGSYP--CSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637
           QG  P     P P   P  A Y           S +          S  GY T S P   
Sbjct: 537 QGQQPYYSQQPQPPHLPPQAQY---------LPSQSQQRYQPQQDMSQEGYGTRSQPPLA 587

Query: 638 PYGKRAPSPGAYKTATPPGYKP--GSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPG 695
           P           +   P       GS     TGT          +G  + +         
Sbjct: 588 PGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQS 647

Query: 696 PLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVD 755
           P  P     L S+P  P+    G P+ + Q +  P      P S +P    P PP    +
Sbjct: 648 PFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMP----PQPPGSQSE 703

Query: 756 VPSHASQS 763
             SH + S
Sbjct: 704 SSSHPALS 711



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 144/602 (23%), Positives = 196/602 (32%), Gaps = 97/602 (16%)

Query: 222 GGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPV- 280
           GG GG   G   G  GGG  +  GG   G          + +  G  G          V 
Sbjct: 251 GGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVL 310

Query: 281 -----GGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHLPSPHA 334
                 GG +   P       ++       A      A  +    GA P L   L SP  
Sbjct: 311 SSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSP 370

Query: 335 MGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAP---------------APPMRFPYSSSS 379
           M +  GG  P     P+  P P S P + ++A                   M   Y+++S
Sbjct: 371 MMRSYGGSYP-EYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAAS 429

Query: 380 SSSAAASSSSSSSSSSASPFPA---SQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQA 436
            + AAA   S  + S  +P P    SQ  P  P     P    + + P    Q S P   
Sbjct: 430 PAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPG 489

Query: 437 VWSQGPPPPPPY-----GR---LLANSNAHPGPFPPSTGAQSTA---------------H 473
             S GPP P  Y     GR    +A         PP  G Q  +                
Sbjct: 490 -GSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQ 548

Query: 474 PPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMS 533
           PP       +   Q QQ+ Q QQ   Q+ +   S PP     P+  +        P ++ 
Sbjct: 549 PPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLP 608

Query: 534 PSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP-SPSQ 592
              GS+   P G        ++ + S A        S+S S+SS    S P   P SP  
Sbjct: 609 DLSGSIDDLPTG--------TEATLSSA-------VSASGSTSSQGDQSNPAQSPFSPHA 653

Query: 593 GPQ-----GAPYPFP---PVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP 644
            P      G P P P   PV +  + S  +S      AS P       PPG        P
Sbjct: 654 SPHLSSIPGGPSPSPVGSPVGSNQSRSGPISP-----ASIPGSQMPPQPPGSQSESSSHP 708

Query: 645 SPGAYKTATPPGYKPG---SPPSFRTGTPPGYRGTSPPAGPG--------TFKPGSPTVG 693
           +          G+  G   +P   + G        SP   PG        +F+  + +  
Sbjct: 709 ALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGT 768

Query: 694 PGP-LPPAGPSGLPSLPPP----PAAPAS--GPPLSATQIKQEPAEEYETPESPVPPARS 746
            GP +   GP G  S PP     P+A  S  GP +  +   Q   +    P   VP  R 
Sbjct: 769 YGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRM 828

Query: 747 PS 748
           PS
Sbjct: 829 PS 830



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 118/515 (22%), Positives = 175/515 (33%), Gaps = 104/515 (20%)

Query: 289  PPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEK 348
            PPP  F   T +    P L+P      SP   G+   P    +P + G       PG  K
Sbjct: 1091 PPPEVFS--TGDTKKQPKLQP-----PSPANSGSLQGP---QTPQSTGSNSMAEVPGDLK 1140

Query: 349  GPTLAPSPHS--LPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSS------------ 394
             PT A +PH    P     +    +  P+S  S SS    +S + ++             
Sbjct: 1141 PPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMG 1200

Query: 395  ------SASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPY 448
                  +  PF   + +P     F     +  S+    Y Q    + +    G     PY
Sbjct: 1201 RMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPY 1260

Query: 449  G-----RLLANSNAHPGPFPPST-----GAQSTAHPPVSTHHHH-----------HQQQQ 487
            G     R       +PG  PPS      G Q   +P    +  H           H+   
Sbjct: 1261 GASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDM 1320

Query: 488  QQQQQQQQQQQQQQQHHGN-SGP---PPPGAFPHP-----LEGGSSHHAH---------P 529
               Q   QQQ+   Q+ G+ SGP   P  G +P+P     ++G      H         P
Sbjct: 1321 YNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGP 1380

Query: 530  YAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGP---PVSSSSNSSSSTSQGSYPCS 586
               S S G  +        +P P+     ++ GP GP   P     N +          +
Sbjct: 1381 LQSSSSEGPQQNMWAARNDMPYPYQ----NRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN 1436

Query: 587  HPS--PSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP 644
            H S  PS   Q  PY         +SSA++  +     + P      +PP  P +  RAP
Sbjct: 1437 HESQWPSHVSQRQPY--------MSSSASMQPI-----TRPPQPSYQTPPSLPNHISRAP 1483

Query: 645  SPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSG 704
            SP +++ +      P   P   +        T P          S   GP P PP  P  
Sbjct: 1484 SPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPT---------SQVTGPPPQPP--PIR 1532

Query: 705  LPSLPPPPAAPASGPPLSATQIKQEPAEEYETPES 739
                 PP +  AS P L   Q ++  +++  TPE+
Sbjct: 1533 REITFPPGSVEASQPVLK--QRRKITSKDIVTPEA 1565



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 74/277 (26%), Positives = 94/277 (33%), Gaps = 60/277 (21%)

Query: 460 GPFPPSTGAQSTAHPPVSTHHHHHQ----------------QQQQQQQQQQQQQQQQQQH 503
           G  P +   Q   H   + HHHHH                 QQQQQQQQQQQQQQQQQQH
Sbjct: 15  GEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQH 74

Query: 504 HGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGP 563
             ++     GA      GG +    P    P  G  +    G              QA P
Sbjct: 75  PISNNNSLGGA------GGGAPQPGPDMEQPQHGGAKDSAAG-------------GQADP 115

Query: 564 NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTV-----I 618
            GPP+ S                 P     P G  Y  P +  + T    ++        
Sbjct: 116 PGPPLLSKPGDEDDA---------PPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGP 166

Query: 619 ATVASSPAGYKTASPPGPPPYGKRAP---------SPGAYKTATPPGYKPGSPPSF--RT 667
           A V      Y +A+P    P G+  P         SPG     +      G+P S     
Sbjct: 167 AAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQ 226

Query: 668 GTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSG 704
            +  GY  +     PG  +PG+   G G     G SG
Sbjct: 227 NSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSG 263



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 109/462 (23%), Positives = 156/462 (33%), Gaps = 100/462 (21%)

Query: 60   EEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSS 119
            E  ST    KQ + +  S + S     P+  ++       + P DL      S    G  
Sbjct: 1094 EVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPAS-TPHGQM 1152

Query: 120  DPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHP----PPLFPPSPQPPDST 175
             P    Q  RS++ S++ P S  +DS      S  P  PY      P +    P  P+  
Sbjct: 1153 TPM---QGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKD 1209

Query: 176  P------------------RQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAP---- 213
            P                  + P +S +   + +P+G  + +     + F  P GA     
Sbjct: 1210 PFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQF--PYGASYDRR 1267

Query: 214  -PPHPQLYPGGTGGVLSGPPMG--PKGGGA-------------ASSVGGPNGGKQHPPPT 257
              P+ Q YPG       GPP G  P GG                  + GP   K+H    
Sbjct: 1268 HEPYGQQYPG------QGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGP-PAKRHEGDM 1320

Query: 258  TPISVSSS-----GASGAPPTKPPTTPVGGGNLPSAPPPANFPHV-------TPNLPPPP 305
              +  SS         G   + P   P+ G      P P +   +       T  +PP  
Sbjct: 1321 YNMQYSSQQQEMYNQYGGSYSGPDRRPIQG----QYPYPYSRERMQGPGQIQTHGIPPQM 1376

Query: 306  ALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSS 365
               PL ++S+  P          +P P+   QG G        GPT AP P+     +  
Sbjct: 1377 MGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPG--------GPTQAP-PYPGMNRTDD 1427

Query: 366  APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPF-----PASQALPSYPHSF---PPPTS 417
               P  R  + S   S  +      SSS+S  P      P+ Q  PS P+     P P S
Sbjct: 1428 MMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS 1487

Query: 418  L--SVSNQPPKYTQPSLPSQAVWS----------QGPPPPPP 447
               S+ N+      P LPS  +             GPPP PP
Sbjct: 1488 FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPP 1529


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score =  102 bits (253), Expect = 3e-21
 Identities = 182/777 (23%), Positives = 249/777 (32%), Gaps = 187/777 (24%)

Query: 59  VEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGS 118
           VE    P + K+   +E  + + E  N        +E+   +     D  DGR  +++G+
Sbjct: 298 VEPVGRPSILKEDNLKEFDQLDQE--NDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGA 355

Query: 119 SDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQ 178
              RD    +    P          ++D   G S   + P  P   +  + +PP++ P  
Sbjct: 356 EGHRDSQSASGEERPP---------EADGKKGNSPN-SEPPTPKTAWAETSRPPETEPGP 405

Query: 179 PEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGP--- 235
           P     P P + P     P   P       PPG  P               GPP  P   
Sbjct: 406 PA----PKPPLPP-----PHRGPAGNW--GPPGDYPDR------------GGPPCKPPAP 442

Query: 236 -----------KGGGAASSVGGPNGGKQHPPPTTPISVSSSGAS-----------GAPPT 273
                      K   +  S+      ++       +      A            GAP  
Sbjct: 443 EDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDK 502

Query: 274 KPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPH 333
           +    P      PS P P   P V   LP PPA                 P P   P+P 
Sbjct: 503 RLKAEPAAPPAAPSTPAPP--PAVPKELPAPPA-----------------PPPASAPTPE 543

Query: 334 AMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSS 393
                       PE+       P   PPA S+        P   S   S +++SS S  +
Sbjct: 544 TE----------PEE-------PAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEA 586

Query: 394 SSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLA 453
           S   P   S+  P  P   PPPT+  V    PK              GP   PP   L  
Sbjct: 587 SPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGD----------GIGPTRQPPSQGL-- 634

Query: 454 NSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPP- 512
               +P            + PP        Q+QQQ+Q  +QQQQ Q QQH   S PP P 
Sbjct: 635 ---GYP--------KYQKSLPP------RFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPV 677

Query: 513 ----------GAFPHPLEGGSSHHAHPYAMSP-SLGSLRPYPP---GPAHLP-PPHSQVS 557
                     GA P P     +    P A+ P +LG   P PP    P  +  PP+    
Sbjct: 678 PPSPPQPVTLGAVPAP----QAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPR 733

Query: 558 YSQAGP----NGPPVSSSS----NSSSSTSQGSYPCSHPSPSQGPQGAPYPFPP----VP 605
             Q  P      P V  S       S S    S P    +P+   +    P  P    V 
Sbjct: 734 LLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVG 793

Query: 606 TVTTSSAT-----LSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATP------ 654
            V T++        S +         G ++ +PP PPP    A  PG  +   P      
Sbjct: 794 DVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISR 853

Query: 655 -----PG-----YKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSG 704
                PG     + PGS    +  TPP  +    P    T +   P  G  P    G  G
Sbjct: 854 FPLEEPGPRPLPWPPGSDEVAKIQTPPPKK---EPPKEETAQLTGPEAGRKPARGVGSGG 910

Query: 705 LPSLPPPPAAPASGP----PLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVP 757
               PPPP   +       P   +  +  P EE   P     P + P PP KV ++P
Sbjct: 911 --QGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELP 965



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 165/696 (23%), Positives = 218/696 (31%), Gaps = 183/696 (26%)

Query: 162  PPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYP 221
            PP  P +P PP + P++  A   P P+  PT    P EP      QAPP    P P    
Sbjct: 511  PPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPA-----QAPPAQSTPTP---- 561

Query: 222  GGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTT--- 278
                GV + P +   GGG+ SS    + G     P  P   S  G        PPTT   
Sbjct: 562  ----GVAAAPTL-VSGGGSTSST---SSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPV 613

Query: 279  ----PVGGGNLPSAPPPA---NFPHVTPNLPP---------------------------P 304
                P G G  P+  PP+    +P    +LPP                           P
Sbjct: 614  PKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAP 673

Query: 305  PALRPLNNASASPPGLGAQPLP-GHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363
            P   P+  +   P  LGA P P    P P A+  G  G PP P       P    +PP  
Sbjct: 674  PT--PVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPP-PMPPMNFDPRWMMIPPYV 730

Query: 364  SS---APAPPMRFPYSSSSSSSAAASSSSSSSSSSASPF----PAS-------------- 402
                    PP+ F       S       S S  SS+ PF    PA               
Sbjct: 731  DPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLA 790

Query: 403  ------QALPSYPHSFPPPTSLSV--------SNQPP-KYTQPSLPSQAVWSQGPPPPPP 447
                   A P+ P     P   +         S  PP     P L S   + +   P PP
Sbjct: 791  WVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPP 850

Query: 448  YGRL-LANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGN 506
              R  L      P P+PP +   +    P        ++  Q    +  ++  +    G 
Sbjct: 851  ISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGG 910

Query: 507  SGPPPPGA--------FPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSY 558
             GPPPP           P P   GSS    P    P      P   GP   PPP ++V  
Sbjct: 911  QGPPPPRRESRTETRWGPRP---GSSRRGIP----PEEPGAPPRRAGPIKKPPPPTKVEE 963

Query: 559  SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVI 618
                                         P P +     P P  P P   T         
Sbjct: 964  LP---------------------------PKPLEQGDETPKPPKPDPLKITKG------- 989

Query: 619  ATVASSPAGYKTASPPGPPPYGKRAPSPG-----AYKTATPPGYK-PGSPPSFRTGTPPG 672
                      K   P   PP G  +P+P      +Y+   P   +  G    F  G   G
Sbjct: 990  ----------KLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGR--G 1037

Query: 673  YRGTSPPAGPG-------TFKPGSPTVGPGPLPPAGPSGLPSLPPPP-AAPASGPPLSAT 724
            +RGT    G G       +++      G G     G +G P+ PP P    AS      +
Sbjct: 1038 FRGTYGGRGRGARSREFRSYREFRGDDGRG-----GGTGGPNHPPAPRGRTASETRSEGS 1092

Query: 725  QIKQEPAEE--------YETPESPVPPARSPSPPPK 752
            + ++ P            ET ES + P+   +P PK
Sbjct: 1093 EYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPK 1128



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 219/989 (22%), Positives = 300/989 (30%), Gaps = 211/989 (21%)

Query: 166  PPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAP-------PPHPQ 218
            PP P PP      P   F  + +  P     P+E P  R    PPG+        PP  +
Sbjct: 826  PPVPPPPPYLASYP--GFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKK 883

Query: 219  LYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSS-------SGASGAP 271
              P      L+GP  G K    A  VG  +GG+  PPP       +       S   G P
Sbjct: 884  EPPKEETAQLTGPEAGRK---PARGVG--SGGQGPPPPRRESRTETRWGPRPGSSRRGIP 938

Query: 272  PTKPPTTPVGGGNLPSAPPPANFPHVTPN-------LPPPPALRPLNNASASPPGLGAQP 324
            P +P   P   G +   PPP     + P         P PP   PL        G    P
Sbjct: 939  PEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETP 998

Query: 325  LPGHL-PSPH------------------------AMGQGMGGLPPGPEKG---------- 349
              G+L P+P                         A G+G  G   G  +G          
Sbjct: 999  PNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYR 1058

Query: 350  --------------PTLAPSPHSLPPASSSAPAP-----PMRFPYSSSSSSSAAASSSSS 390
                          P   P+P     + + +        P R     S + S    S  +
Sbjct: 1059 EFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLA 1118

Query: 391  SSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPS--------LPSQAVWSQGP 442
             S   A P P    L   P + PPP     S  P ++T           +PS+     G 
Sbjct: 1119 PSDKEA-PTPKEGTLTQVPLA-PPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGR 1176

Query: 443  PPPP------PYGRLLANSNAHPGPFPPSTG-------------------------AQST 471
            PPP       P  + LA      GP PPS                               
Sbjct: 1177 PPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMED 1236

Query: 472  AHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP---PGAFPHPLEGGSSHHAH 528
               P    H   QQQ +  + ++ +Q+++    G+ G P    P + P P E  ++    
Sbjct: 1237 GERPRRRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTV--- 1293

Query: 529  PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588
                     ++ P P   A   P  S  +  QA       S SS+ +S            
Sbjct: 1294 ---------TVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSER---------- 1334

Query: 589  SPSQGPQGAPYPFPPVP-TVTTSSATLSTVIATVASSPAG--YKTASPPGPPPYGKRAPS 645
               +G + AP P    P  V T        +  +++   G   + A       +  + P 
Sbjct: 1335 ---RGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPG 1391

Query: 646  PGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGL 705
                     PG K GS  S   G   G  G + P         SP     P P   P GL
Sbjct: 1392 MERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRP-PEERPPGL 1450

Query: 706  PSLPPPPAAPA---------SGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDV 756
            P  PPPP++ A         S P      I+Q  A+      S   P   P   P +   
Sbjct: 1451 PLPPPPPSSSAVFRLDQVIHSNP----AGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQA 1506

Query: 757  PSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKE 816
            P   S      ++  +  NS   SD +F         ++   +V  V       A     
Sbjct: 1507 PQGPSPRPP-TRYEPQRVNSGLSSDPHF---------EEPGPMVRGVGGTPRDSAGVSPF 1556

Query: 817  REREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYL 876
              + RER             R  +L QE   P            PP   G  + + P   
Sbjct: 1557 PPKRRERP-----------PRKPELLQEESLP------------PPHSSG-FLGSKPEGP 1592

Query: 877  GPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAARERERE 936
            GP   +  T +E   PH+    NR H            +  +  P     D A  E  + 
Sbjct: 1593 GPQAESRDTGTEALTPHIW---NRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQS 1649

Query: 937  ARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGG---LALQP--GPPGLHPFPF 991
                DL    +           P  G+ G    P  R GG   L   P  GPPG  P P 
Sbjct: 1650 DSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEP-PR 1708

Query: 992  HPSLGPLERERLALAAGPALRPDMSYAER 1020
             P   P + +R  L     L P     ER
Sbjct: 1709 RPPPAPHDGDRKELPREQPLPPGPIGTER 1737



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 205/846 (24%), Positives = 281/846 (33%), Gaps = 163/846 (19%)

Query: 13   RSGRKKEAPGP------REELRSRGRASPGGVSTS---SSDGKAEK--SRQTAKKARVEE 61
            R GR ++   P      ++E  +  R S G  S +   S+ G  E   +   A   R   
Sbjct: 1244 RHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAA 1303

Query: 62   ASTPKVNKQG--RSEEISESESEETNAPKKTKTEQELPRPQ--SPSDLDS--------LD 109
            A +P ++ Q   ++ E  E+ SE ++   + + ++E P P   +P  + +        + 
Sbjct: 1304 AKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVP 1363

Query: 110  GRSLNDDGSSDPRDIDQDNRSTS---PSIY------SPGSVENDSDSSSGLS-------Q 153
            G S    G    R  D   RS S   P +        PG     S SSSG          
Sbjct: 1364 GISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRT 1423

Query: 154  GPAR---------------PYHPPPLFPPSPQPPDSTPRQPEASFEPHPSV--TPTGYHA 196
            GP R               P   PP  P  P PP S+     A F     +   P G   
Sbjct: 1424 GPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSS-----AVFRLDQVIHSNPAGIQQ 1478

Query: 197  PMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPP 256
             +   +SR  Q    AP  HP+  PG     L   P GP                  PP 
Sbjct: 1479 ALAQLSSR--QGSVTAPGGHPRHKPG-----LPQAPQGPS---------------PRPPT 1516

Query: 257  TTPISVSSSGASGAPPTKPPTTPVGG--GNLPSAPPPANFPHVTPNLPP-PPALRPLNNA 313
                   +SG S  P  + P   V G  G    +   + FP      PP  P L  L   
Sbjct: 1517 RYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPEL--LQEE 1574

Query: 314  SASPPG----LGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAP 369
            S  PP     LG++P  G  P   +   G   L P        A S  S  P+S      
Sbjct: 1575 SLPPPHSSGFLGSKP-EGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWME 1633

Query: 370  PMR-FPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYT 428
            P+  F   + +  S + S    S  S  S  P SQ       S P       +  PPK  
Sbjct: 1634 PLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQ------RSSPDGGLKGAAEGPPKRP 1687

Query: 429  QPSLPSQAVWSQGPP--------PPPPYG----RLLANSNAHPGPFPPSTGAQS---TAH 473
              S P  AV  +GPP        PP P+      L       PGP       ++   T  
Sbjct: 1688 GGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEP 1747

Query: 474  PPVSTHHHHHQQQQQQQQQQQQQQQ--------QQQQHHGNSGPPPPGAFPHPLEGGSSH 525
             P+   H      Q     +    +         +++   +     P +    L   ++ 
Sbjct: 1748 GPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAA 1807

Query: 526  HAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSS-NSSSSTSQGSY- 583
             A P + +   G   P P        P  +V Y  AGP+   +S  + +S    + G + 
Sbjct: 1808 SAEPQSKNLDSGHCVPEPSSSGQRLYP--EVFYGSAGPSSSQISGGAMDSQLHPNSGGFR 1865

Query: 584  ---PCSHPSPSQGPQGAPYPFPPVPTVTTSSAT-----LSTVIAT-VASSPAG------- 627
               P  HP  SQ     P P PP   ++  +        ST+ AT +   PAG       
Sbjct: 1866 PGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPP 1925

Query: 628  ---YKTASPPGPPP------YGKRAPSPGA-YKTATPPGYKPGSPPSFRTGTPPGYRGTS 677
               Y  A  P P P        +  PSP   Y T   PG + G  PS      P  +   
Sbjct: 1926 SFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPS----GAPAQQMLL 1981

Query: 678  PPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEE-YET 736
            P           P V  G LPPA P   P L   P  PA  PP  A +    PA     +
Sbjct: 1982 PMVDSQL-----PVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPS 2036

Query: 737  PESPVP 742
            P  P P
Sbjct: 2037 PARPFP 2042



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 166/768 (21%), Positives = 249/768 (32%), Gaps = 169/768 (22%)

Query: 16  RKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEE 75
           R+   P     L++  + +   VS    DG    S+Q     +  +AST +  +   S+ 
Sbjct: 54  RRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPE---SQP 110

Query: 76  ISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSL----NDDGSSDPRDIDQDNRST 131
           +  S++  +N PK+     E   P  PS + S    S+    + DG      + + +R  
Sbjct: 111 LPASQTPASNQPKRPPAAPE-NTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREE 169

Query: 132 SPSIYSPGSVENDSDS--SSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSV 189
            P++ + G  +  +    S+  S GP           PS +P +ST  +      P    
Sbjct: 170 FPTLQAAGDQDKAAKERESAEQSSGPG----------PSLRPQNSTTWRDGGGRGPDE-- 217

Query: 190 TPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG 249
                   +E P S++         P   L P       SGPP  P           P  
Sbjct: 218 --------LEGPDSKLHHGHD----PRGGLQP-------SGPPQFP-----------PYR 247

Query: 250 GKQHP---PPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPA 306
           G   P   PP  P               PP  P G    P+   P+ FP V       P 
Sbjct: 248 GMMPPFMYPPYLPFP-------------PPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPP 294

Query: 307 LRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSA 366
           +R L      P  L    L            G  G     +    L  S           
Sbjct: 295 MR-LVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEE-------- 345

Query: 367 PAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFP--PPTSLSVSNQP 424
                      S    A     S S+S    P  A     + P+S P  P T+ + +++P
Sbjct: 346 -------DGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRP 398

Query: 425 PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484
           P+ T+P  P+       PP PPP+ R  A +   PG +P   G       P        Q
Sbjct: 399 PE-TEPGPPAPK-----PPLPPPH-RGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQ 451

Query: 485 QQQQ------------QQQQQQQQQQQQQQHH---------------------------- 504
           +++Q            ++++++++++ Q++                              
Sbjct: 452 RRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAP 511

Query: 505 --GNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAG 562
               S P PP A P  L       A P     S  +    P  PA  PP  S  +   A 
Sbjct: 512 PAAPSTPAPPPAVPKELP------APPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAA 565

Query: 563 PNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVA 622
              P + S   S+SSTS GS+  S   P    +  P P   VP  TT             
Sbjct: 566 --APTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVP--------K 615

Query: 623 SSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSF-----RTGTPPGYRGTS 677
             P G        PP  G   P    Y+ + PP ++            +       +G++
Sbjct: 616 VEPKGDGIGPTRQPPSQGLGYPK---YQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSA 672

Query: 678 PPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPP----PAAPASGPPL 721
           PP       P   T+G  P P A P      PPP    P A    PP+
Sbjct: 673 PPTPVPPSPPQPVTLGAVPAPQAPP------PPPKALYPGALGRPPPM 714



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 186/828 (22%), Positives = 248/828 (29%), Gaps = 167/828 (20%)

Query: 2    KTRQNKDSMSMRSG--RKKEAPGPREELRSRGRASPGG---VSTSSSDGKAEKSRQTAKK 56
            K    +   S R G  R+   PGP  +  S G +S GG       +  G+ +K    + K
Sbjct: 1378 KDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPK 1437

Query: 57   --ARVEEASTPKV---------------------NKQGRSEEISESESEETNA------P 87
              +R  E   P +                     N  G  + +++  S + +       P
Sbjct: 1438 NRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHP 1497

Query: 88   KKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDS 147
            +      + P+  SP      + + +N   SSDP           P +   G    DS  
Sbjct: 1498 RHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHF-----EEPGPMVRGVGGTPRDS-- 1550

Query: 148  SSGLSQGPARPYHPPPLFP--------PSPQPPDSTPRQPEASFEPHPSVTPTGYHA--- 196
             +G+S  P +    PP  P        P P        +PE    P      TG  A   
Sbjct: 1551 -AGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGP-GPQAESRDTGTEALTP 1608

Query: 197  ----PMEPPTSRMFQAPPGAPPPHPQLYP--GGTGGVLSGPPMGPKGGGAASSVGGPNGG 250
                 +   TSR    P    P    L P     G  +S    G    G +    GP   
Sbjct: 1609 HIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQ 1668

Query: 251  KQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPL 310
            +  P           GA+  PP +P     GG +  +A P    P   P   PPPA    
Sbjct: 1669 RSSPDG------GLKGAAEGPPKRP-----GGSSPLNAVPCEGPPGSEPPRRPPPA---- 1713

Query: 311  NNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGP---EKGPTLAPSPHSLPPASSSAP 367
                  P     + LP   P           LPPGP   E+           P   S  P
Sbjct: 1714 ------PHDGDRKELPREQP-----------LPPGPIGTERSQRTDRGTEPGPIRPSHRP 1756

Query: 368  APPMRFPYSSSSSS-------SAAASSSSSSSSSSASPFPAS-QALPSYPHSFPPPTSLS 419
             PP++F  S   S        S  A    ++S + A P     + LPS   S  P +   
Sbjct: 1757 GPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNL 1816

Query: 420  VSN----QPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHP--GPFPPSTGA----- 468
             S     +P    Q   P     S GP      G  + +S  HP  G F P T +     
Sbjct: 1817 DSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAM-DSQLHPNSGGFRPGTPSLHPYR 1875

Query: 469  -------QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPP-----PGAFP 516
                      A P         + Q       Q  +  +    G   PPP     P   P
Sbjct: 1876 SQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCP 1935

Query: 517  HPLEGGSSHHAHPYAMSPSLGSLRPYPPG----------PAH---LPPPHSQVSYSQAG- 562
             PL   S         SPS     P  PG          PA    LP   SQ+     G 
Sbjct: 1936 SPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGS 1995

Query: 563  -PNGPPVSSSSNSSSSTSQGSYPCS---HPSPSQGPQGAPYPFPPVPTVTTSSATLSTVI 618
             P  PP +    S         P S    P P+   +  P P  P P     +      +
Sbjct: 1996 LPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVEL 2055

Query: 619  ATVASSPAGYKTASPPGP---PPYG----------KRAPSP--GAYKTATPPGYKPGSPP 663
                           PG    PP G          K  PS   G ++T     Y+  SPP
Sbjct: 2056 KPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVDLYQQASPP 2115

Query: 664  SFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711
                  P  +  T PP   G   P      PG    +     P LPPP
Sbjct: 2116 DALRWIPKPWERTGPPPREG---PSRRAEEPG----SRGDKEPGLPPP 2156



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 160/687 (23%), Positives = 219/687 (31%), Gaps = 141/687 (20%)

Query: 354 PSPHSLPP--ASSSAPAPPMRF-PYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPH 410
           P P +LP   A +    P +   P   +  +S    S   SS +S +  P SQ LP+   
Sbjct: 57  PPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPA--- 113

Query: 411 SFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQS 470
                      +Q P   QP  P  A   +  P  P   +  A ++   G    + G   
Sbjct: 114 -----------SQTPASNQPKRPPAA--PENTPLVPSGVKSWAQASVTHG----AHGDGG 156

Query: 471 TAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPP-------------GAFPH 517
            A   +S          Q    Q +  ++++    +SGP P              G  P 
Sbjct: 157 RASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPD 216

Query: 518 PLEGGSS--HHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVS---YSQAGPNGPPVSSSS 572
            LEG  S  HH H        G L+P   GP   PP    +    Y    P  PP     
Sbjct: 217 ELEGPDSKLHHGHD-----PRGGLQP--SGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQG 269

Query: 573 NSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATV----------- 621
                T  G  P   P  + GP+G+  P   V  V   S      +              
Sbjct: 270 PYRYPTPDG--PSRFPRVA-GPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGW 326

Query: 622 --ASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPP--GYRGTS 677
             A     Y           G+ +   GA       G++     S     P   G +G S
Sbjct: 327 AGAHEEVDYTEKLKFSDEEDGRDSDEEGA------EGHRDSQSASGEERPPEADGKKGNS 380

Query: 678 PPAGPGTFKPG-SPTVGPGPLPPAGPSGLPSLPPPPAAPAS--GPPLSATQIKQEPAEEY 734
           P + P T K   + T  P    P  P+  P LPPP   PA   GPP              
Sbjct: 381 PNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPP-------------G 427

Query: 735 ETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAK 794
           + P+   PP + P+P  +         QS+               S++         LA 
Sbjct: 428 DYPDRGGPPCKPPAPEDEDEAWRQRRKQSS---------------SEI--------SLAV 464

Query: 795 KRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSL 854
           +RA    + RRE E+R  +E+ R    E+ K   R  E+      +L  E  AP   PS 
Sbjct: 465 ERA----RRRREEEERRMQEERRAACAEKLK---RLDEKFGAPDKRLKAEPAAPPAAPS- 516

Query: 855 GPVPHRPPFEPGSAVA-TVPPYLGPDTPALRTLSEYARPHVMS---PGNRNHPFYVPLGA 910
              P  PP  P    A   PP     TP          P   S   PG    P  V  G 
Sbjct: 517 --TPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGG 574

Query: 911 VDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDP 970
                         +S  ++   E    E  L  +  P     P E+ P    P P ++P
Sbjct: 575 -------------STSSTSSGSFEASPVEPQLPSKEGP---EPPEEVPPPTTPPVPKVEP 618

Query: 971 FPRHGGLALQPGPPGLHPFPFHPSLGP 997
                G   QP   GL    +  SL P
Sbjct: 619 KGDGIGPTRQPPSQGLGYPKYQKSLPP 645



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 93/377 (24%), Positives = 122/377 (32%), Gaps = 93/377 (24%)

Query: 656  GYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGP-GPLPPAGPSGLPSLPPPPAA 714
            G +P  PP F     P YRG  PP     + P  P  GP GP     P G PS  P  A 
Sbjct: 234  GLQPSGPPQF-----PPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDG-PSRFPRVAG 287

Query: 715  P-ASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRG 773
            P  SGPP+                   V P   PS     +    +  +  + ++  D G
Sbjct: 288  PRGSGPPMRL-----------------VEPVGRPS-----ILKEDNLKEFDQLDQENDDG 325

Query: 774  FNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKER 833
            +                  A +  D  EK++   E+  R+  E   E  R+ +    +ER
Sbjct: 326  WAG----------------AHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEER 369

Query: 834  ELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPH 893
              E   K   +G +P   P   P P     +   A  + PP   P  PA +       PH
Sbjct: 370  PPEADGK---KGNSPNSEP---PTP-----KTAWAETSRPPETEPGPPAPK--PPLPPPH 416

Query: 894  VMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAARE-----------------RERE 936
                GN   P   P    D G      PA    D A R+                 R RE
Sbjct: 417  RGPAGNWGPPGDYP----DRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRRE 472

Query: 937  ARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLG 996
              ER +++  +     K   L+   G P   L   P          PP     P  P   
Sbjct: 473  EEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEP--------AAPPAAPSTPAPPPAV 524

Query: 997  PLERERLALAAGPALRP 1013
            P E     L A PA  P
Sbjct: 525  PKE-----LPAPPAPPP 536


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score =  101 bits (251), Expect = 5e-21
 Identities = 191/827 (23%), Positives = 266/827 (32%), Gaps = 187/827 (22%)

Query: 97   PRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPA 156
            P P  P D     G+      SS        + S + S           +S  G + GP 
Sbjct: 512  PEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPL 571

Query: 157  RPYHPPPLFPPSPQPPDST---PRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAP 213
            RP  PPP       P  +T   P  P       P          +EPP   +  APP   
Sbjct: 572  RP--PPPGAGGPATPSKATRFLPMDPATFRRKRPESV-----GGLEPPGPSVIAAPPSGG 624

Query: 214  ---------PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNG----GKQHPPPTTPI 260
                     PP+ +   GG   V S P      G  A+ +  P          P  +TP+
Sbjct: 625  GNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPV 684

Query: 261  SVSS-----SGASGAPPTK--------------PPTTPVGGGNLPSAPPPANFPHVTPNL 301
             ++S     SG + A P                P  +P+G   + S    A      P+L
Sbjct: 685  PIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHL 744

Query: 302  PPPPALRPLNNASAS-------PPGLGAQ------------------------------- 323
               P L  +  A A+        PG GA                                
Sbjct: 745  VAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNG 804

Query: 324  PLPGHLPSPHAMGQGMGGLPPGPEKGPTL------APSPHSLPPASSSAPAPPMRFPYSS 377
            P+P  +  P A+G+  GG+       PTL      AP+P   P   ++AP+ P   P +S
Sbjct: 805  PVPLGILQPGALGKA-GGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPA--PTTS 861

Query: 378  SSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVS--NQPP---------- 425
               +    +S++    ++ +P P    L S P S PPP + SVS    PP          
Sbjct: 862  IRFTLPPGTSTNGKVLAATAPTPGIPILQSVP-SAPPPKAQSVSPVQAPPPGGSAQLLPG 920

Query: 426  KYTQP-SLPSQAVWSQGPPPP-----PPYGRLLANSNAHPG------PFPPSTGAQSTAH 473
            K   P + PS +V   G   P     PP+   + N    P       P P ST   S   
Sbjct: 921  KVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVST--PSGLV 978

Query: 474  PPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMS 533
            PP+S         Q Q+       +            P G  P   + G+     P   S
Sbjct: 979  PPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGP-TSS 1037

Query: 534  PSLGSLRPYPPGPAHLPP--------------------PHSQVSYSQAGPNGPPVSSSSN 573
             +LG     P GPA + P                    P  Q+  + A P GP +++  +
Sbjct: 1038 VALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYS 1097

Query: 574  SSSSTSQGSYPCSHPSP-SQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTAS 632
             S            P+P S  P   P   PP    T +++T       +   P    TA+
Sbjct: 1098 GS------------PAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATAT 1145

Query: 633  PPGPPPYGKRAPSPGAYKTATPPGYKPG--SPPSFR---TGTPPG--YRGTSPPAGPGTF 685
            P    P+         Y    P   +P   +P   +      P G    G S   GP   
Sbjct: 1146 PAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPR 1205

Query: 686  KPGSPTVGPGPLPPAGPSGLPSLPPPPAAP----------ASGPPLSATQIKQEPAEEYE 735
            +P  P  GP   P A  S L   P PPA P           S PPL     ++  A+  E
Sbjct: 1206 QPLEP--GPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPE 1263

Query: 736  TPESPVP------------------PARSPSPPPKVVDVPSHASQSA 764
            T  S  P                  P   PSP P     P  +S+S+
Sbjct: 1264 TMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESS 1310



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 180/759 (23%), Positives = 249/759 (32%), Gaps = 146/759 (19%)

Query: 79   SESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSP 138
            S S+   +   T  E+ +   +   D D +      DDG     DID   +       S 
Sbjct: 424  SRSQRAASEDMTSDEERMVICEEEGDDDVIA-----DDGFGTT-DIDLKCKERVTDSESG 477

Query: 139  GSVENDSDSSSGLSQGPARP-------YHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTP 191
             S   D + + G  +    P       +  PPL P  P PPD     P A  + + S   
Sbjct: 478  DSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPD----PPVAFGKGYGSAPS 533

Query: 192  TGYHAPMEPPTSRMFQAPPGAPPPHPQ-LYPGGTGGVLSGPPMGPKGGGAAS-------- 242
            +   +P     S       G+     Q    G T G L  PP G  G    S        
Sbjct: 534  SSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPM 593

Query: 243  -----------SVGGPNGGKQHPPPTTPISVSSSGASG------APPTKPPTTPVGGGNL 285
                       SVGG       PP  + I+   SG          PP K      GG  +
Sbjct: 594  DPATFRRKRPESVGG-----LEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEG-GGARV 647

Query: 286  PSAPPPANFPHVTPNLPPPPALRP--------LNNASASPPGLGAQPLPGHLPSPHAMGQ 337
            PSAP P+    +    P  P  RP        +   S++P  + ++P P           
Sbjct: 648  PSAPAPS----LAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFP---------TS 694

Query: 338  GMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS 397
            G     P    G        S  P  S     P+      S   SAAA       +S A 
Sbjct: 695  GRAEASPNDTAGARTEMGTGSRVPGGS-----PLGVSLVYSDKKSAAA-------TSPAP 742

Query: 398  PFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457
               A   L +   +    T+L V    P Y  P+ P+    +QG P         A + +
Sbjct: 743  HLVAGPLLGTVGKAPATVTNLLVGT--PGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGS 800

Query: 458  HP-GPFP---PSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPG 513
             P GP P      GA   A       +      QQ Q           +    SGP P  
Sbjct: 801  GPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTT 860

Query: 514  AFPHPLEGGSSHHAHPYAM---SPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSS 570
            +    L  G+S +    A    +P +  L+  P  P   PP    VS  QA P G     
Sbjct: 861  SIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAP---PPKAQSVSPVQAPPPG----- 912

Query: 571  SSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFP--------PVPTVTTSSATLSTVIATVA 622
              ++     +   P + PS S    GA  P P        PV       + +  +     
Sbjct: 913  -GSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPV 971

Query: 623  SSPAG----YKTASPPGPPPYGKRAPSPGAYKT---------ATPPGYKPGSPPSFRTGT 669
            S+P+G       A+ PGP    ++   P + +          A P G    SP S + GT
Sbjct: 972  STPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLG---TSPASSQAGT 1028

Query: 670  PPGYRGTSP---------PAGPGTFKP-----GSPTVGPGPLPPAGPSGLPSLPPPPAAP 715
               Y  TS          P+GP   +P      +P + PG +   G S +PS   PPA  
Sbjct: 1029 VTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQV---GVSPVPSPQLPPACA 1085

Query: 716  ASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVV 754
            A G P+        PA     P S  P A+    PP +V
Sbjct: 1086 APGGPVITAFYSGSPA-----PTSSAPLAQPSQAPPSLV 1119



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 75/275 (27%), Positives = 93/275 (33%), Gaps = 79/275 (28%)

Query: 154  GPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAP 213
            G   P    PL  PS  PP        ++  P  ++ P G      PP      AP  A 
Sbjct: 1098 GSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKG------PP------APATAT 1145

Query: 214  PPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSS-------- 265
            P     +P  T G ++   + PK               Q P P  P  V ++        
Sbjct: 1146 PAPTSPFPSATAGSMTYSLVAPKA--------------QRPSPKAPQKVKAAIASIPVGS 1191

Query: 266  ---GASGAP-----------PTKPPTTP---VGGGNLPSAPPP-----ANFPHVTPNLPP 303
               GASG P           P + PT P   + G   P APPP           +P LPP
Sbjct: 1192 FEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPP 1251

Query: 304  PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMG--GLPPGPEKGPTLAPSPHSLPP 361
            P   R     SA  P   A   P         GQG+   G PP P       PSP     
Sbjct: 1252 PAEER----TSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTP-------PSP----- 1295

Query: 362  ASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSA 396
                APAP +  P  SS SSS  A+  +     +A
Sbjct: 1296 ----APAPAVA-PGGSSESSSGRAAGDTPERKEAA 1325



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 108/442 (24%), Positives = 145/442 (32%), Gaps = 112/442 (25%)

Query: 378 SSSSSAAASSSSSSSSSSASPFPASQALPSYPHS-FPPPTSLSVSNQPPKYTQPSLPSQA 436
           SS + A  SSS  +        P S    ++ HS         V +Q  +     +   A
Sbjct: 325 SSDTKAPGSSSCGAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPA 384

Query: 437 VWSQGPPPPPPYGRLLANSNAHPGPF--PPSTGA-QSTAHPPV-STHHHHHQQQQQQQQQ 492
            +S GP P   YG         PGPF  P   GA  +T  PP+  T     Q+   +   
Sbjct: 385 SYS-GPKPSTQYGA--------PGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMT 435

Query: 493 QQQQQQQQQQHHGNSGPPPPGAFPHP------------LEGGSSHHAHPYA--------M 532
             +++    +  G+        F                E G S    P           
Sbjct: 436 SDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVF 495

Query: 533 SPSLGS--------LRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYP 584
           SP + S        L P PPGP     P   V++ +   + P  S+SS +SSS S     
Sbjct: 496 SPVIRSSFTHCRPPLDPEPPGP-----PDPPVAFGKGYGSAPSSSASSPASSSAS----- 545

Query: 585 CSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAP 644
                                    +S +L +       S  G  TA P  PPP      
Sbjct: 546 -----------------------AATSFSLGSGTFKAQESGQG-STAGPLRPPP------ 575

Query: 645 SPGAYKTATP---PGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPG------ 695
            PGA   ATP     + P  P +FR   P    G  PP GP      +P  G G      
Sbjct: 576 -PGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPP-GPSVI--AAPPSGGGNILQTL 631

Query: 696 PLPP------AGPSGLPSLPPP------PAAPASGPPLSATQIKQEPAEEYETPESPVPP 743
            LPP       G + +PS P P      PAAP S P  +       P        +PVP 
Sbjct: 632 VLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVS-----STPVPI 686

Query: 744 ARSPSPPPKVVDVPSHASQSAR 765
           A  P P     +   + +  AR
Sbjct: 687 ASKPFPTSGRAEASPNDTAGAR 708



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 48/163 (29%), Positives = 66/163 (40%), Gaps = 21/163 (12%)

Query: 632 SPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTS-PPAGPGTFKPGSP 690
           S P P      A  P ++  A+    +P    +     PPG  G++ P   PG   P SP
Sbjct: 47  SQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESP 106

Query: 691 TVGPGPLPPAGPSGLPSLPPPPA-APASGPPLSATQIKQEPAEEYE-------TPE--SP 740
             GPGP  P G       PPP     ASGPP    ++  E   +++       +PE   P
Sbjct: 107 --GPGPPHPLGVVESGKGPPPTTEEEASGPP-GEPRLDSETESDHDDAFLSIMSPEIQLP 163

Query: 741 VPPAR----SPSPPPKVVDVPSH---ASQSARFNKHLDRGFNS 776
           +PP +    S S  PK  D  S     S + R   H+ R  N+
Sbjct: 164 LPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNA 206



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 28/77 (36%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 207  QAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSG 266
            + PPGA  P P   P GT      P   P GG   +S    +G  Q  PP  P   S  G
Sbjct: 1526 EQPPGAEAPLPVPPPTGTAAA-PAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPG 1584

Query: 267  A---SGAP-PTKPPTTP 279
                 GAP P+ PP  P
Sbjct: 1585 QPGWEGAPQPSPPPPGP 1601



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 33/100 (33%), Positives = 36/100 (36%), Gaps = 20/100 (20%)

Query: 648  AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707
            A  T  PPG +   P    TGT      T  PAG           GP P  P+  SG   
Sbjct: 1522 ATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAG-----------GPDPTSPSSDSGTAQ 1570

Query: 708  LPPP-PAAPASGPPLSATQIKQEPAEEYETPESPVPPARS 746
              PP P  P SGP         +P  E     SP PP  S
Sbjct: 1571 AAPPLPPPPESGP--------GQPGWEGAPQPSPPPPGPS 1602



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 14/100 (14%)

Query: 619  ATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSP 678
            AT    P G +   P  PP     AP+P    T +P G    + PS  +GT        P
Sbjct: 1522 ATPTEQPPGAEAPLPVPPPTGTAAAPAP----TPSPAGGPDPTSPSSDSGTAQAAPPLPP 1577

Query: 679  PAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASG 718
            P   G  +PG     P P PP         PP P+  A+G
Sbjct: 1578 PPESGPGQPGWEG-APQPSPP---------PPGPSTAATG 1607



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 47/163 (28%), Positives = 58/163 (35%), Gaps = 27/163 (16%)

Query: 164 LFPPSPQPPDSTPRQPEASFEP----HPSVTPTGYHAPMEPPTSRMF---QAPPGAPPPH 216
           +FP     P   P QP+ S +P     P+  P   +   EP  S      + P G     
Sbjct: 34  VFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSAD 93

Query: 217 PQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPP 276
           P+  PG T     GP       G    +G    GK  PPPTT        ASG     PP
Sbjct: 94  PERPPGATCPESPGP-------GPPHPLGVVESGK-GPPPTT-----EEEASG-----PP 135

Query: 277 TTPVGGGNLPSAPPPANFPHVTP--NLPPPPALRPLNNASASP 317
             P       S    A    ++P   LP PP  R   + SA P
Sbjct: 136 GEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALP 178



 Score = 37.4 bits (85), Expect = 0.086
 Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 2/81 (2%)

Query: 166  PPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPT-SRMFQAPPGAPPPHPQLYPGGT 224
            PP  + P   P     +  P P+ +P G   P  P + S   QA P  PPP P+  PG  
Sbjct: 1528 PPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPP-PESGPGQP 1586

Query: 225  GGVLSGPPMGPKGGGAASSVG 245
            G   +  P  P  G + ++ G
Sbjct: 1587 GWEGAPQPSPPPPGPSTAATG 1607



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 23/104 (22%)

Query: 589  SPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGA 648
            +P++ P GA  P P  P                   P G   A  P P P G   P+  +
Sbjct: 1523 TPTEQPPGAEAPLPVPP-------------------PTGTAAAPAPTPSPAGGPDPTSPS 1563

Query: 649  YKTATPPGYKPGSPPSFRTGTPPGYRG----TSPPAGPGTFKPG 688
              + T     P  PP       PG+ G    + PP GP T   G
Sbjct: 1564 SDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATG 1607



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 23/73 (31%), Positives = 27/73 (36%), Gaps = 13/73 (17%)

Query: 690  PTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPP------ 743
            P     PLP   P+G  + P P  +PA GP    T    +       P  P PP      
Sbjct: 1528 PPGAEAPLPVPPPTGTAAAPAPTPSPAGGP--DPTSPSSDSGTAQAAPPLPPPPESGPGQ 1585

Query: 744  -----ARSPSPPP 751
                 A  PSPPP
Sbjct: 1586 PGWEGAPQPSPPP 1598



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 38/125 (30%), Positives = 46/125 (36%), Gaps = 45/125 (36%)

Query: 343  PPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPAS 402
            PPG E     AP P   P  +++APAP         + S A     +S SS S +    +
Sbjct: 1528 PPGAE-----APLPVPPPTGTAAAPAP---------TPSPAGGPDPTSPSSDSGT----A 1569

Query: 403  QALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPF 462
            QA P  P   PPP S            P  P    W   P P PP           PGP 
Sbjct: 1570 QAAPPLP---PPPES-----------GPGQPG---WEGAPQPSPP----------PPGPS 1602

Query: 463  PPSTG 467
              +TG
Sbjct: 1603 TAATG 1607



 Score = 33.9 bits (76), Expect = 0.95
 Identities = 29/101 (28%), Positives = 35/101 (34%), Gaps = 20/101 (19%)

Query: 251  KQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPL 310
            +Q P    P+ V     + A P   P+ P GG +  S    +      P LPPPP   P 
Sbjct: 1526 EQPPGAEAPLPVPPPTGTAAAPAPTPS-PAGGPDPTSPSSDSGTAQAAPPLPPPPESGP- 1583

Query: 311  NNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPT 351
                   PG    P     PSP          PPGP    T
Sbjct: 1584 -----GQPGWEGAP----QPSPP---------PPGPSTAAT 1606



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 36/133 (27%), Positives = 48/133 (36%), Gaps = 21/133 (15%)

Query: 359 LPPASSSA-------------PAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQAL 405
           L PASS+A             P     FP+ S     A +    S   S A   PAS  +
Sbjct: 8   LMPASSAASRGLGMFVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQ-PASHPV 66

Query: 406 PSYPHSFPPPTSLSVSNQPPKYT---QPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPF 462
            S     P  ++     +PP  T    P  P  A   + P P PP+   +  S    G  
Sbjct: 67  ASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVES----GKG 122

Query: 463 PPSTGAQSTAHPP 475
           PP T  +  + PP
Sbjct: 123 PPPTTEEEASGPP 135



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 20/81 (24%)

Query: 588  PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPG 647
            P+P+  P G P P  P                   SS +G   A+PP PPP       PG
Sbjct: 1547 PAPTPSPAGGPDPTSP-------------------SSDSGTAQAAPPLPPPPESGPGQPG 1587

Query: 648  AYKTATPPGYKPGSPPSFRTG 668
             ++ A  P   P  P +  TG
Sbjct: 1588 -WEGAPQPSPPPPGPSTAATG 1607



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 26/92 (28%), Positives = 34/92 (36%), Gaps = 8/92 (8%)

Query: 174  STP-RQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPP 232
            +TP  QP  +  P P   PTG  A   P  S     P G P P       GT    + PP
Sbjct: 1522 ATPTEQPPGAEAPLPVPPPTGTAAAPAPTPS-----PAGGPDPTSPSSDSGTAQ--AAPP 1574

Query: 233  MGPKGGGAASSVGGPNGGKQHPPPTTPISVSS 264
            + P         G     +  PPP  P + ++
Sbjct: 1575 LPPPPESGPGQPGWEGAPQPSPPPPGPSTAAT 1606



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 23/72 (31%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 409  PHSFPPPTSLSVSNQP-------PKYTQPSLPSQAVWSQGP-PPPPPYGRLLANSNAHPG 460
            P   PPPT  + +  P       P  T PS  S    +  P PPPP  G         P 
Sbjct: 1534 PLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQ 1593

Query: 461  PFPPSTGAQSTA 472
            P PP  G  + A
Sbjct: 1594 PSPPPPGPSTAA 1605



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 30/96 (31%), Positives = 33/96 (34%), Gaps = 20/96 (20%)

Query: 276  PTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAM 335
            PT    G   P   PP       P   P PA  P   + +S  G  AQ  P         
Sbjct: 1524 PTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGT-AQAAP--------- 1573

Query: 336  GQGMGGLPPGPEKGPTL-----APSPHSLPPASSSA 366
                  LPP PE GP       AP P   PP  S+A
Sbjct: 1574 -----PLPPPPESGPGQPGWEGAPQPSPPPPGPSTA 1604


>gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]
          Length = 2285

 Score =  100 bits (249), Expect = 8e-21
 Identities = 172/705 (24%), Positives = 236/705 (33%), Gaps = 108/705 (15%)

Query: 114 NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLF---PPSPQ 170
           N +G++ PR    +N  T P    PG     S    G     A    PPP +    P  +
Sbjct: 102 NSNGNAGPRPA-LNNNLTEP----PGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGR 156

Query: 171 PPDSTPRQPEASFE--------PHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP--QLY 220
            P +      A F         P  +   +G    +EP       +     P H     Y
Sbjct: 157 SPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYY 216

Query: 221 PGGTGG-------VLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGAS----- 268
           P  +          LS P  G  G GAA++ G        PPP++  S SSS +S     
Sbjct: 217 PNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSK------PPPSSSASASSSSSSFAQQR 270

Query: 269 -GAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPG 327
            GA     P+   GG   P+A P  N    +P+        P  + S  P   GA   P 
Sbjct: 271 FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPA 330

Query: 328 HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS-LPPASSSAPAPPM-RFPYSSSSSSSAAA 385
            + S    G            G     S H+ + P SS     P+ R P  SS       
Sbjct: 331 DMAS-QCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQPSSPMDQMGK 389

Query: 386 SSSSSSSSSSASPFPASQALPSYP---HSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQG- 441
                   ++  P+   Q  PS P   H +P        +Q P+    ++  +A  + G 
Sbjct: 390 MRPQPYGGTN--PYSQQQGPPSGPQQGHGYP---GQPYGSQTPQRYPMTMQGRAQSAMGG 444

Query: 442 ---PPPPPPYGRLLANSNAHPG---------PFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489
                  PPYG+   +     G         P P       +  PP  T H     QQQ 
Sbjct: 445 LSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQP 504

Query: 490 QQQQQQQQQQQQQHHGNSGPPP----PGAFPHPLEGGSSH------HAHPYAMSPSLGSL 539
           Q Q  Q Q  Q  +      PP    P  +P        H      ++ P A SP     
Sbjct: 505 QSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSP-YQQQ 563

Query: 540 RPYPPGPAHL------PPPHSQVS----YSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPS 589
           +P  P P+ L      P P SQ S    YSQ     PP    S  S  +   S P S  S
Sbjct: 564 QPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQ--QRFPPPQELSQDSFGSQASSAP-SMTS 620

Query: 590 PSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAY 649
              G +         P      ++L  +  ++   P G + A  PG    G  + S G  
Sbjct: 621 SKGGQEDMNLSLQSRP------SSLPDLSGSIDDLPMGTEGALSPGVSTSG-ISSSQGEQ 673

Query: 650 KTATPPGYKPGSPPSFRTGTPPGYRGTSP-PAGPGTFKPGSPTVG-PGPLPPAGPSGLPS 707
                  + P + P       PG RG SP P G     P S      GPL PA   G   
Sbjct: 674 SNPAQSPFSPHTSPHL-----PGIRGPSPSPVG----SPASVAQSRSGPLSPAAVPGNQM 724

Query: 708 LPPPPAAPASG---PPLSATQIKQEPAEEYETPESPVPPARSPSP 749
            P PP+  +     P ++ + I Q+       P+  +P   SP P
Sbjct: 725 PPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQ--MPQYSSPQP 767



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 178/712 (25%), Positives = 235/712 (33%), Gaps = 108/712 (15%)

Query: 21  PGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESE 80
           P P   L S    +PG  + +++  K   S   +  +     +  +    G     +   
Sbjct: 225 PAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGG 284

Query: 81  SEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGS 140
              T  P  T T  +L    SPS      G     D S  P+D          +    G+
Sbjct: 285 G--TPQPTATPTLNQLLT--SPSSARGYQGYP-GGDYSGGPQDGGAGKGPADMASQCWGA 339

Query: 141 VENDSDSSSGLSQGPARPYHPPPLFPPSP----QPPDSTPRQPEASFEPHPSVTPTGYHA 196
               + +++  S G  +  H  P+ P S     QP   TP QP +  +    + P  Y  
Sbjct: 340 AAAAA-AAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTP-QPSSPMDQMGKMRPQPYGG 397

Query: 197 PMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPP 256
               P S+  Q PP  P      YPG   G  +         G A S  G     Q  PP
Sbjct: 398 TN--PYSQQ-QGPPSGPQ-QGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPP 453

Query: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLP--SAPPPANFPHVTPNLPPPPALRPLNNAS 314
                 S  G  G  P     +P      P  S  PP+  PH  P+    P  +P    S
Sbjct: 454 YGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQS 513

Query: 315 ASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFP 374
           + PP       P H  SP           P P +  T    P S PP S     P  + P
Sbjct: 514 SQPPYSQQPSQPPHQQSP----------APYPSQQSTTQQHPQSQPPYSQ----PQAQSP 559

Query: 375 YSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHS---FPPPTSLSVSNQPPKYTQPS 431
           Y        A S+ S  +   A P P SQ      +S   FPPP  LS         Q S
Sbjct: 560 YQQQQPQQPAPSTLSQQA---AYPQPQSQQSQQTAYSQQRFPPPQELS---------QDS 607

Query: 432 LPSQAVWSQGPPPPPPYGR---LLANSNAHPGPFPPSTGA--------QSTAHPPVSTHH 480
             SQA  S  P      G    +  +  + P   P  +G+        +    P VST  
Sbjct: 608 FGSQA--SSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSG 665

Query: 481 HHHQQQQQQQQQQQQQQQQQQQH-------------------HGNSGPPPPGAFP----- 516
               Q +Q    Q         H                      SGP  P A P     
Sbjct: 666 ISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMP 725

Query: 517 -HPLEGGSSHHAHPYAMSPSLGSLRPY----PPGPAH-LPPPHSQVSYSQAGPNGPPVSS 570
             P  G S    HP     S+   R Y    P  P +  P P S +S  Q  P+G  + +
Sbjct: 726 PRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQ--PSGGQIHT 783

Query: 571 SSNSSSSTSQGSYPCSHPSPSQ-GPQGAPYPFPP----VPTVTTSSATLSTVIATVASSP 625
              S    S GSY    P   Q GPQG  YP  P    +P     SA ++  I  +    
Sbjct: 784 GMGSYQQNSMGSY---GPQGGQYGPQGG-YPRQPNYNALPNANYPSAGMAGGINPMG--- 836

Query: 626 AGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKP---GSPPSFRTG--TPPG 672
           AG +    PG PPYG   P   ++ +     Y P     PP   +G   PPG
Sbjct: 837 AGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPG 888



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 150/640 (23%), Positives = 198/640 (30%), Gaps = 143/640 (22%)

Query: 161 PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLY 220
           PPP  PPS        ++ EA  E   +         M+    +  + P   PP      
Sbjct: 17  PPP--PPSELKKAEQQQREEAGGEA--AAAAAAERGEMKAAAGQESEGPAVGPPQ----- 67

Query: 221 PGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT--KPPTT 278
           P G          G  GGG A S GGP           P   +S+G +G  P      T 
Sbjct: 68  PLGKELQDGAESNGGGGGGGAGSGGGPGA--------EPDLKNSNGNAGPRPALNNNLTE 119

Query: 279 PVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGA-------QPLPGHLPS 331
           P GGG   S+      PH      PPPA         SP  + A       Q   G    
Sbjct: 120 PPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSP 179

Query: 332 PHAMGQGMGGLPPGPEKGPTLAPSPHSLP--------PASSSAPAPPMRFPYSS------ 377
             A  Q  GG    P  GP      H  P        P  S+ P P   +  SS      
Sbjct: 180 GLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTP 239

Query: 378 -SSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL---- 432
            S +++AA S    SSS+SAS   +S A   +        S +    P     P+L    
Sbjct: 240 GSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLL 299

Query: 433 --PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490
             PS A   QG P    Y     +  A  GP   ++     A    +             
Sbjct: 300 TSPSSARGYQGYPGGD-YSGGPQDGGAGKGPADMASQCWGAAAAAAAA------------ 346

Query: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550
                   QQ+ HH    P   G    PL    +    P +    +G +RP P G  +  
Sbjct: 347 -AAASGGAQQRSHHAPMSPGSSGGGGQPL----ARTPQPSSPMDQMGKMRPQPYGGTN-- 399

Query: 551 PPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTS 610
            P+SQ    Q  P+GP             QG      P  SQ PQ  P            
Sbjct: 400 -PYSQ---QQGPPSGP------------QQGHGYPGQPYGSQTPQRYPM----------- 432

Query: 611 SATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTP 670
                T+     S+  G         PPYG++ PS          GY        + G  
Sbjct: 433 -----TMQGRAQSAMGGLSYTQQI--PPYGQQGPS----------GYG-------QQGQT 468

Query: 671 PGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEP 730
           P Y   SP                              PP    P S  P +    +Q+P
Sbjct: 469 PYYNQQSPHPQQ------------------------QQPPYSQQPPSQTPHAQPSYQQQP 504

Query: 731 AEEYETPESPVPP-ARSPSPPPKVVDVPSHASQSARFNKH 769
             +    +S  PP ++ PS PP       + SQ +   +H
Sbjct: 505 QSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQH 544



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 131/585 (22%), Positives = 178/585 (30%), Gaps = 95/585 (16%)

Query: 65  PKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDI 124
           P   +QG S    + ++   N       +Q+ P  Q P         S      S P  +
Sbjct: 452 PPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQL 511

Query: 125 DQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPP--DSTPRQPEAS 182
                  S     P   ++ +   S  S     P   PP   P  Q P     P+QP   
Sbjct: 512 QSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQP--- 568

Query: 183 FEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPP--MGPKGGGA 240
             P        Y  P    + +   +    PPP  +L     G   S  P     KGG  
Sbjct: 569 -APSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQ-ELSQDSFGSQASSAPSMTSSKGGQE 626

Query: 241 ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPAN--FPHVT 298
             ++   +     P  +  I     G  GA      T+ +       + P  +   PH +
Sbjct: 627 DMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTS 686

Query: 299 PNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG-LPPGPEKGPTLAPSPH 357
           P+LP       +   S SP G           SP ++ Q   G L P    G  + P P 
Sbjct: 687 PHLP------GIRGPSPSPVG-----------SPASVAQSRSGPLSPAAVPGNQMPPRPP 729

Query: 358 SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
           S    S S   P M     SS +        +      +SP P S   P  P      T 
Sbjct: 730 S--GQSDSIMHPSMN---QSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTG 784

Query: 418 LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVS 477
           +        Y Q S+ S         P   Y R   N NA P    PS G     +P   
Sbjct: 785 MG------SYQQNSMGSYGPQGGQYGPQGGYPR-QPNYNALPNANYPSAGMAGGINP--- 834

Query: 478 THHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYA-----M 532
                                   Q HG  G PP G  P      +S    PY      M
Sbjct: 835 -------------------MGAGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANM 875

Query: 533 SPSLGSLRPYPPGPAHLPPPHSQVSYSQAG---PNGPPVSSSSNSSSSTSQGSYPCSHPS 589
            P +GS    PPG  +     + V+   A     N PP   + N      QG    + P 
Sbjct: 876 PPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMN------QGGMMGTGPP 929

Query: 590 PSQG---------PQGAPYPFPPVPTVTTSSATLSTVIATVASSP 625
             QG         PQG PY         +   T++   A +A+SP
Sbjct: 930 YGQGINSMAGMINPQGPPY---------SMGGTMANNSAGMAASP 965



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 119/545 (21%), Positives = 172/545 (31%), Gaps = 100/545 (18%)

Query: 251  KQHPPPTTPISVSSSGASGAPPTKPPTTP--VGGGNLPSAPPPANFPHVTPNLPPPPALR 308
            K+  P   P S + SG+   P T   T+     GG+L   P PA+ PH    +PP P + 
Sbjct: 1124 KKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDL-KPPTPASTPH--SQIPPLPGMS 1180

Query: 309  PLNNA-----------SASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGP--TLAPS 355
              N+            S         P PG+ PS +     MG +   P K P  ++  +
Sbjct: 1181 RSNSVGIQDAFNDGSDSTFQKRNSMTPNPGYQPSMNTSDM-MGRMSYEPNKDPYGSMRKA 1239

Query: 356  PHSLPPASSS----------------------APAPPMRFPYSSSSSSSAAASSSSSSSS 393
            P S P  SS                       A  P   +PY                 +
Sbjct: 1240 PGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGN 1299

Query: 394  SSASPFPASQALPSYPHS-------FPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPP 446
             S    P    +PS P S       +PP        +   Y      +Q   S  P P  
Sbjct: 1300 MSTGA-PQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGN-QFSTQGTPSGSPFPSQ 1357

Query: 447  PYGRLLANSNAHPGPFPPSTGAQSTAHP------PVSTHHHHHQQQQ----------QQQ 490
                       +  P   + G  +  H       P ST     QQQQ          QQQ
Sbjct: 1358 QTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQ 1417

Query: 491  QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550
              Q   QQ     +GN+ P    A       G   +  P+       S  P      ++P
Sbjct: 1418 AAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMP 1477

Query: 551  PPHSQVSYSQAGPNGPPVSSSSNSSSSTS--QGSYPCSHPSPSQGPQGAPYPFPPVPTVT 608
            P             G P+ +S+  +   +  QG    ++   ++   G+    P    V 
Sbjct: 1478 PQMM----------GGPIQASAEVAQQGTMWQGRNDMTYNYANRQSTGSAPQGPAYHGVN 1527

Query: 609  TSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTG 668
             +   L T      ++  G   +     PPYG  AP P   +   P  Y+P  PPS +  
Sbjct: 1528 RTDEMLHT---DQRANHEGSWPSHGTRQPPYGPSAPVPPMTR-PPPSNYQP--PPSMQNH 1581

Query: 669  TPPGYRGTSPPAGPGTFKPGSPTVGPGPLP-PAGPSGLPSLPPPPAAPASGPPLSATQIK 727
             P               +  SP   P P+     PS  P L        +GPP+ A+ I 
Sbjct: 1582 IP---------------QVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIA 1626

Query: 728  QEPAE 732
              P +
Sbjct: 1627 PAPVQ 1631



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 81/374 (21%), Positives = 117/374 (31%), Gaps = 55/374 (14%)

Query: 127  DNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPH 186
            D   T P I   G++   +   + +   P    + P  +PP  Q      +Q   S+   
Sbjct: 1286 DRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQ---QQQQQRHDSYGNQ 1342

Query: 187  PSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAAS---S 243
             S   T   +P     + M+Q          Q Y     G   GPP     G   S   S
Sbjct: 1343 FSTQGTPSGSPFPSQQTTMYQ-------QQQQNYKRPMDGTY-GPPAKRHEGEMYSVPYS 1394

Query: 244  VGGPNGGKQHPPPTTPISVSSSGASGAPPTK----------PPTTPVGGGNLPSAPPPAN 293
             G     +Q  PP  P   S   A+   P +          P T        P+  P   
Sbjct: 1395 TGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQ 1454

Query: 294  FPHV--TPNLPPPPALRPLNNASASPPGLGAQPL--PGHLPSPHAMGQGMGGLPPGPEKG 349
            FP       +  PP      N    PP +   P+     +     M QG   +       
Sbjct: 1455 FPFQFGRDRVSAPPGTNAQQN---MPPQMMGGPIQASAEVAQQGTMWQGRNDMTYN---- 1507

Query: 350  PTLAPSPHSLPPASSSAPAPPMRFPYSSSSS---SSAAASSSSSSSSSSASPFPASQALP 406
                   ++   ++ SAP  P     + +     +   A+   S  S      P   + P
Sbjct: 1508 -------YANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAP 1560

Query: 407  SYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPST 466
              P + PPP++     QPP   Q  +P   V S  P P P   R    ++    PF  S 
Sbjct: 1561 VPPMTRPPPSNY----QPPPSMQNHIPQ--VSSPAPLPRPMENR----TSPSKSPFLHSG 1610

Query: 467  GAQSTAHPPVSTHH 480
                 A PPV   H
Sbjct: 1611 MKMQKAGPPVPASH 1624



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 84/382 (21%), Positives = 122/382 (31%), Gaps = 85/382 (22%)

Query: 416  TSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP 475
            +S + S+   +Y Q     +    +G  PPP       +  + P   PPS     +   P
Sbjct: 1085 SSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGP 1144

Query: 476  VSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPH----PLEGGSSHHAHPYA 531
                            Q  Q         G+  PP P + PH    PL G S        
Sbjct: 1145 ----------------QTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMS-------- 1180

Query: 532  MSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPS 591
             S S+G    +  G        + ++     PN P    S N+S    + SY      P+
Sbjct: 1181 RSNSVGIQDAFNDGSDSTFQKRNSMT-----PN-PGYQPSMNTSDMMGRMSY-----EPN 1229

Query: 592  QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPG--PPPYGKRAPSPGAY 649
            + P G+    P                    S P       P G    PY  RA  PG  
Sbjct: 1230 KDPYGSMRKAP-------------------GSDPFMSSGQGPNGGMGDPY-SRAAGPGLG 1269

Query: 650  KTAT-PPGYKPGSPPSFRTGTPPGYRGTSPPAGP-GTFKPGSPTVGPGPLPPAGPSGLPS 707
              A  P  + P   P  R  T PG        GP G    G+P   P  +P    SG+ S
Sbjct: 1270 NVAMGPRQHYPYGGPYDRVRTEPG-------IGPEGNMSTGAPQ--PNLMPSNPDSGMYS 1320

Query: 708  LPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFN 767
                   P+  PP    Q +Q          +   P+ SP P  +      +  Q   + 
Sbjct: 1321 -------PSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTT---MYQQQQQNYK 1370

Query: 768  KHLDRGFNSCAR---SDLYFVP 786
            + +D  +   A+    ++Y VP
Sbjct: 1371 RPMDGTYGPPAKRHEGEMYSVP 1392


>gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]
          Length = 2068

 Score =  100 bits (249), Expect = 8e-21
 Identities = 172/705 (24%), Positives = 236/705 (33%), Gaps = 108/705 (15%)

Query: 114 NDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLF---PPSPQ 170
           N +G++ PR    +N  T P    PG     S    G     A    PPP +    P  +
Sbjct: 102 NSNGNAGPRPA-LNNNLTEP----PGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGR 156

Query: 171 PPDSTPRQPEASFE--------PHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHP--QLY 220
            P +      A F         P  +   +G    +EP       +     P H     Y
Sbjct: 157 SPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYY 216

Query: 221 PGGTGG-------VLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGAS----- 268
           P  +          LS P  G  G GAA++ G        PPP++  S SSS +S     
Sbjct: 217 PNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSK------PPPSSSASASSSSSSFAQQR 270

Query: 269 -GAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPG 327
            GA     P+   GG   P+A P  N    +P+        P  + S  P   GA   P 
Sbjct: 271 FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPA 330

Query: 328 HLPSPHAMGQGMGGLPPGPEKGPTLAPSPHS-LPPASSSAPAPPM-RFPYSSSSSSSAAA 385
            + S    G            G     S H+ + P SS     P+ R P  SS       
Sbjct: 331 DMAS-QCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQPSSPMDQMGK 389

Query: 386 SSSSSSSSSSASPFPASQALPSYP---HSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQG- 441
                   ++  P+   Q  PS P   H +P        +Q P+    ++  +A  + G 
Sbjct: 390 MRPQPYGGTN--PYSQQQGPPSGPQQGHGYP---GQPYGSQTPQRYPMTMQGRAQSAMGG 444

Query: 442 ---PPPPPPYGRLLANSNAHPG---------PFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489
                  PPYG+   +     G         P P       +  PP  T H     QQQ 
Sbjct: 445 LSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQP 504

Query: 490 QQQQQQQQQQQQQHHGNSGPPP----PGAFPHPLEGGSSH------HAHPYAMSPSLGSL 539
           Q Q  Q Q  Q  +      PP    P  +P        H      ++ P A SP     
Sbjct: 505 QSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSP-YQQQ 563

Query: 540 RPYPPGPAHL------PPPHSQVS----YSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPS 589
           +P  P P+ L      P P SQ S    YSQ     PP    S  S  +   S P S  S
Sbjct: 564 QPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQ--QRFPPPQELSQDSFGSQASSAP-SMTS 620

Query: 590 PSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAY 649
              G +         P      ++L  +  ++   P G + A  PG    G  + S G  
Sbjct: 621 SKGGQEDMNLSLQSRP------SSLPDLSGSIDDLPMGTEGALSPGVSTSG-ISSSQGEQ 673

Query: 650 KTATPPGYKPGSPPSFRTGTPPGYRGTSP-PAGPGTFKPGSPTVG-PGPLPPAGPSGLPS 707
                  + P + P       PG RG SP P G     P S      GPL PA   G   
Sbjct: 674 SNPAQSPFSPHTSPHL-----PGIRGPSPSPVG----SPASVAQSRSGPLSPAAVPGNQM 724

Query: 708 LPPPPAAPASG---PPLSATQIKQEPAEEYETPESPVPPARSPSP 749
            P PP+  +     P ++ + I Q+       P+  +P   SP P
Sbjct: 725 PPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQ--MPQYSSPQP 767



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 178/712 (25%), Positives = 235/712 (33%), Gaps = 108/712 (15%)

Query: 21  PGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESE 80
           P P   L S    +PG  + +++  K   S   +  +     +  +    G     +   
Sbjct: 225 PAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGG 284

Query: 81  SEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGS 140
              T  P  T T  +L    SPS      G     D S  P+D          +    G+
Sbjct: 285 G--TPQPTATPTLNQLLT--SPSSARGYQGYP-GGDYSGGPQDGGAGKGPADMASQCWGA 339

Query: 141 VENDSDSSSGLSQGPARPYHPPPLFPPSP----QPPDSTPRQPEASFEPHPSVTPTGYHA 196
               + +++  S G  +  H  P+ P S     QP   TP QP +  +    + P  Y  
Sbjct: 340 AAAAA-AAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTP-QPSSPMDQMGKMRPQPYGG 397

Query: 197 PMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPP 256
               P S+  Q PP  P      YPG   G  +         G A S  G     Q  PP
Sbjct: 398 TN--PYSQQ-QGPPSGPQ-QGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPP 453

Query: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLP--SAPPPANFPHVTPNLPPPPALRPLNNAS 314
                 S  G  G  P     +P      P  S  PP+  PH  P+    P  +P    S
Sbjct: 454 YGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQS 513

Query: 315 ASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFP 374
           + PP       P H  SP           P P +  T    P S PP S     P  + P
Sbjct: 514 SQPPYSQQPSQPPHQQSP----------APYPSQQSTTQQHPQSQPPYSQ----PQAQSP 559

Query: 375 YSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHS---FPPPTSLSVSNQPPKYTQPS 431
           Y        A S+ S  +   A P P SQ      +S   FPPP  LS         Q S
Sbjct: 560 YQQQQPQQPAPSTLSQQA---AYPQPQSQQSQQTAYSQQRFPPPQELS---------QDS 607

Query: 432 LPSQAVWSQGPPPPPPYGR---LLANSNAHPGPFPPSTGA--------QSTAHPPVSTHH 480
             SQA  S  P      G    +  +  + P   P  +G+        +    P VST  
Sbjct: 608 FGSQA--SSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSG 665

Query: 481 HHHQQQQQQQQQQQQQQQQQQQH-------------------HGNSGPPPPGAFP----- 516
               Q +Q    Q         H                      SGP  P A P     
Sbjct: 666 ISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMP 725

Query: 517 -HPLEGGSSHHAHPYAMSPSLGSLRPY----PPGPAH-LPPPHSQVSYSQAGPNGPPVSS 570
             P  G S    HP     S+   R Y    P  P +  P P S +S  Q  P+G  + +
Sbjct: 726 PRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQ--PSGGQIHT 783

Query: 571 SSNSSSSTSQGSYPCSHPSPSQ-GPQGAPYPFPP----VPTVTTSSATLSTVIATVASSP 625
              S    S GSY    P   Q GPQG  YP  P    +P     SA ++  I  +    
Sbjct: 784 GMGSYQQNSMGSY---GPQGGQYGPQGG-YPRQPNYNALPNANYPSAGMAGGINPMG--- 836

Query: 626 AGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKP---GSPPSFRTG--TPPG 672
           AG +    PG PPYG   P   ++ +     Y P     PP   +G   PPG
Sbjct: 837 AGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPG 888



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 150/640 (23%), Positives = 198/640 (30%), Gaps = 143/640 (22%)

Query: 161 PPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLY 220
           PPP  PPS        ++ EA  E   +         M+    +  + P   PP      
Sbjct: 17  PPP--PPSELKKAEQQQREEAGGEA--AAAAAAERGEMKAAAGQESEGPAVGPPQ----- 67

Query: 221 PGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPT--KPPTT 278
           P G          G  GGG A S GGP           P   +S+G +G  P      T 
Sbjct: 68  PLGKELQDGAESNGGGGGGGAGSGGGPGA--------EPDLKNSNGNAGPRPALNNNLTE 119

Query: 279 PVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGA-------QPLPGHLPS 331
           P GGG   S+      PH      PPPA         SP  + A       Q   G    
Sbjct: 120 PPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSP 179

Query: 332 PHAMGQGMGGLPPGPEKGPTLAPSPHSLP--------PASSSAPAPPMRFPYSS------ 377
             A  Q  GG    P  GP      H  P        P  S+ P P   +  SS      
Sbjct: 180 GLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTP 239

Query: 378 -SSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL---- 432
            S +++AA S    SSS+SAS   +S A   +        S +    P     P+L    
Sbjct: 240 GSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLL 299

Query: 433 --PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490
             PS A   QG P    Y     +  A  GP   ++     A    +             
Sbjct: 300 TSPSSARGYQGYPGGD-YSGGPQDGGAGKGPADMASQCWGAAAAAAAA------------ 346

Query: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550
                   QQ+ HH    P   G    PL    +    P +    +G +RP P G  +  
Sbjct: 347 -AAASGGAQQRSHHAPMSPGSSGGGGQPL----ARTPQPSSPMDQMGKMRPQPYGGTN-- 399

Query: 551 PPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTS 610
            P+SQ    Q  P+GP             QG      P  SQ PQ  P            
Sbjct: 400 -PYSQ---QQGPPSGP------------QQGHGYPGQPYGSQTPQRYPM----------- 432

Query: 611 SATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTP 670
                T+     S+  G         PPYG++ PS          GY        + G  
Sbjct: 433 -----TMQGRAQSAMGGLSYTQQI--PPYGQQGPS----------GYG-------QQGQT 468

Query: 671 PGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEP 730
           P Y   SP                              PP    P S  P +    +Q+P
Sbjct: 469 PYYNQQSPHPQQ------------------------QQPPYSQQPPSQTPHAQPSYQQQP 504

Query: 731 AEEYETPESPVPP-ARSPSPPPKVVDVPSHASQSARFNKH 769
             +    +S  PP ++ PS PP       + SQ +   +H
Sbjct: 505 QSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQH 544



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 131/585 (22%), Positives = 178/585 (30%), Gaps = 95/585 (16%)

Query: 65  PKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDI 124
           P   +QG S    + ++   N       +Q+ P  Q P         S      S P  +
Sbjct: 452 PPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQL 511

Query: 125 DQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPP--DSTPRQPEAS 182
                  S     P   ++ +   S  S     P   PP   P  Q P     P+QP   
Sbjct: 512 QSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQP--- 568

Query: 183 FEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPP--MGPKGGGA 240
             P        Y  P    + +   +    PPP  +L     G   S  P     KGG  
Sbjct: 569 -APSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQ-ELSQDSFGSQASSAPSMTSSKGGQE 626

Query: 241 ASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPAN--FPHVT 298
             ++   +     P  +  I     G  GA      T+ +       + P  +   PH +
Sbjct: 627 DMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTS 686

Query: 299 PNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGG-LPPGPEKGPTLAPSPH 357
           P+LP       +   S SP G           SP ++ Q   G L P    G  + P P 
Sbjct: 687 PHLP------GIRGPSPSPVG-----------SPASVAQSRSGPLSPAAVPGNQMPPRPP 729

Query: 358 SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS 417
           S    S S   P M     SS +        +      +SP P S   P  P      T 
Sbjct: 730 S--GQSDSIMHPSMN---QSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTG 784

Query: 418 LSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVS 477
           +        Y Q S+ S         P   Y R   N NA P    PS G     +P   
Sbjct: 785 MG------SYQQNSMGSYGPQGGQYGPQGGYPR-QPNYNALPNANYPSAGMAGGINP--- 834

Query: 478 THHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYA-----M 532
                                   Q HG  G PP G  P      +S    PY      M
Sbjct: 835 -------------------MGAGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANM 875

Query: 533 SPSLGSLRPYPPGPAHLPPPHSQVSYSQAG---PNGPPVSSSSNSSSSTSQGSYPCSHPS 589
            P +GS    PPG  +     + V+   A     N PP   + N      QG    + P 
Sbjct: 876 PPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMN------QGGMMGTGPP 929

Query: 590 PSQG---------PQGAPYPFPPVPTVTTSSATLSTVIATVASSP 625
             QG         PQG PY         +   T++   A +A+SP
Sbjct: 930 YGQGINSMAGMINPQGPPY---------SMGGTMANNSAGMAASP 965



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 186/869 (21%), Positives = 278/869 (31%), Gaps = 143/869 (16%)

Query: 60   EEASTPKVNKQGRSEEISESESEETN---APKKTKTEQELP--RPQSPSDLDSLDGRSLN 114
            E A +P V+  G    IS S+ E++N   +P    T   LP  R  SPS + S    + +
Sbjct: 654  EGALSPGVSTSG----ISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQS 709

Query: 115  DDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDS 174
              G   P  +  +     P      S+ + S + S ++Q   R Y        +PQ P  
Sbjct: 710  RSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQD--RGY-----MQRNPQMPQY 762

Query: 175  TPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMG 234
            +  QP ++  P     P+G    +        Q   G+  P      GG  G   G P  
Sbjct: 763  SSPQPGSALSPRQ---PSG--GQIHTGMGSYQQNSMGSYGPQ-----GGQYGPQGGYPRQ 812

Query: 235  PKGGG-------AASSVGGPN----GGKQHPPPTTPISVSSSGASGAPP--TKPP--TTP 279
            P           +A   GG N    GG+ H  P            G PP  T PP   + 
Sbjct: 813  PNYNALPNANYPSAGMAGGINPMGAGGQMHGQP------------GIPPYGTLPPGRMSH 860

Query: 280  VGGGNLPSAPPPANFPHVTPN--LPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQ 337
               GN P  P  AN P    +   PPP  +      +A    + A  +    P    M Q
Sbjct: 861  ASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMNQ 920

Query: 338  GMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSAS 397
            G G +  GP  G  +      + P       PP     + +++S+  A+S          
Sbjct: 921  G-GMMGTGPPYGQGINSMAGMINPQG-----PPYSMGGTMANNSAGMAASPEMMGLGDVK 974

Query: 398  PFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNA 457
              PA++ + +     P   S S  +     T   +         P       R LA +  
Sbjct: 975  LTPATK-MNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEE 1033

Query: 458  HPGPFPPSTGAQSTAHPPVSTHHHHHQQQQ-----QQQQQQQQQQQQQQQHHGNSGPPPP 512
                    T   +    P+  +  +   ++     Q  + ++ ++     + G S     
Sbjct: 1034 KAMGM---TNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAAS 1090

Query: 513  G----------AFPHPLEGGSSHHAHPYAMSPSLGSL-RPYPPGPAHLPPPHSQVSYSQA 561
                       AF   +E G       +A + S  S  +  PP PA         S S  
Sbjct: 1091 SLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAG--------SGSMQ 1142

Query: 562  GPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATV 621
            GP  P  +SSS +     +   P S P             PP+P ++ S++         
Sbjct: 1143 GPQTPQSTSSSMAEGGDLKPPTPASTPHSQ---------IPPLPGMSRSNSVGIQDAFND 1193

Query: 622  ASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPG-----YRGT 676
             S     K  S    P Y    PS           Y+P   P       PG       G 
Sbjct: 1194 GSDSTFQKRNSMTPNPGY---QPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQ 1250

Query: 677  SPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEP--AEEY 734
             P  G G   P S   GPG        G  ++ P    P  GP     +++ EP    E 
Sbjct: 1251 GPNGGMG--DPYSRAAGPG-------LGNVAMGPRQHYPYGGP---YDRVRTEPGIGPEG 1298

Query: 735  ETPESPVPPARSPSPPPKVVDVPSH---ASQSARFNKHLDRGFNSCARSDLYFVPLEGSK 791
                    P   PS P   +  PS      Q  +  +H   G     +         GS 
Sbjct: 1299 NMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGNQFSTQG-----TPSGSP 1353

Query: 792  LAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVEC 851
               ++  +        +Q+ +        R  E      K   L   +K+ + G  PV  
Sbjct: 1354 FPSQQTTMY-------QQQQQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAG-PPVPA 1405

Query: 852  PSLGPVPHRPP-------FEPGSAVATVP 873
              + P P +PP       F PGS  AT P
Sbjct: 1406 SHIAPAPVQPPMIRRDITFPPGSVEATQP 1434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.129    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,160,451
Number of Sequences: 37866
Number of extensions: 6356628
Number of successful extensions: 148920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1474
Number of HSP's successfully gapped in prelim test: 3399
Number of HSP's that attempted gapping in prelim test: 36426
Number of HSP's gapped (non-prelim): 54527
length of query: 1190
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1076
effective length of database: 13,930,794
effective search space: 14989534344
effective search space used: 14989534344
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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