Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 55743108
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 1237 0.0
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 415 e-116
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 409 e-114
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 122 1e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 113 6e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 104 3e-22
gi|16554627 WD repeat domain 5 [Homo sapiens] 104 3e-22
gi|32189425 WD repeat domain 69 [Homo sapiens] 100 4e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 89 1e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 89 1e-17
gi|26665869 WD repeat domain 51B [Homo sapiens] 89 2e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 85 2e-16
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 84 4e-16
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 81 3e-15
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 80 7e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 80 7e-15
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 80 7e-15
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 78 3e-14
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 78 3e-14
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 78 3e-14
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 77 4e-14
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 76 8e-14
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 75 2e-13
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 75 2e-13
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] 73 7e-13
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] 73 7e-13
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 73 9e-13
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 73 9e-13
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 72 2e-12
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 71 3e-12
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 1237 bits (3200), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPE 60
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPE
Sbjct: 1 MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPE 60
Query: 61 PNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGT 120
PNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGT
Sbjct: 61 PNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGT 120
Query: 121 LESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAA 180
LESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAA
Sbjct: 121 LESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAA 180
Query: 181 LRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD 240
LRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD
Sbjct: 181 LRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD 240
Query: 241 TLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKR 300
TLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKR
Sbjct: 241 TLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKR 300
Query: 301 RGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI 360
RGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI
Sbjct: 301 RGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI 360
Query: 361 HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG 420
HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG
Sbjct: 361 HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG 420
Query: 421 HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH 480
HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH
Sbjct: 421 HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH 480
Query: 481 NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF
Sbjct: 481 NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
Query: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC 600
RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC
Sbjct: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC 600
Query: 601 YSGSHMVSVDQGRKVVLWQ 619
YSGSHMVSVDQGRKVVLWQ
Sbjct: 601 YSGSHMVSVDQGRKVVLWQ 619
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 415 bits (1067), Expect = e-116
Identities = 239/618 (38%), Positives = 348/618 (56%), Gaps = 21/618 (3%)
Query: 5 GVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSV 64
G+ A RWKRHI QLR RDR Q+ F E++ YN LLEK++L ++KLQ E + V
Sbjct: 4 GLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDV 63
Query: 65 TPTTHQ-GPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLES 123
P H+ P + + +Q+ + LR+K QEE L GE+A V++ + +
Sbjct: 64 -PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDR 122
Query: 124 ELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRR 183
E+Q ++++A ++ L ++ + N + Y+AL+ E LR+
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
Query: 184 LQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD--T 241
EE ++L+ R + KA+ A N NE+ R +QAR+ +EL +AAK + + + D
Sbjct: 183 TTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEV 242
Query: 242 LGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRR 301
+ D + E E P+ + KR + A ++ + + RR
Sbjct: 243 IVDETSDHTE------ETSPVRAISRAATKRLSQPAGG----------LLDSITNIFGRR 286
Query: 302 GHSIGGAPEQRYQIIPVC-VAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI 360
S P+ P R+P A V DAH EVNAV+F P S LLATGG DR +
Sbjct: 287 SVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRV 346
Query: 361 HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG 420
LW V G + E +L G+ ITS++FD +G +LAA+ + A+++W V + + + TL+G
Sbjct: 347 KLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTG 406
Query: 421 HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH 480
H KV +AKF L + V+GS DRT+K WDL C +T+ S CND+VC + ++SGH
Sbjct: 407 HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGH 466
Query: 481 NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
D+KIRFWD R + + + G++T+L L+ ++ LLSCSRD+ LKVIDLR + I+Q F
Sbjct: 467 FDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTF 526
Query: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC 600
A GFKCGSDWT+ VFSPD SY AGS +G+LYIW V TGK+E L H +++NAVAW
Sbjct: 527 SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWS 586
Query: 601 YSGSHMVSVDQGRKVVLW 618
SGSH+VSVD+G K VLW
Sbjct: 587 PSGSHVVSVDKGCKAVLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 409 bits (1052), Expect = e-114
Identities = 237/618 (38%), Positives = 342/618 (55%), Gaps = 40/618 (6%)
Query: 5 GVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSV 64
G+ A RWKRHI QLR RDR Q+ F E++ YN LLEK++L ++KLQ E + V
Sbjct: 4 GLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDV 63
Query: 65 TPTTHQ-GPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLES 123
P H+ P + + +Q+ + LR+K QEE L GE+A V++ + +
Sbjct: 64 -PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDR 122
Query: 124 ELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRR 183
E+Q ++++A ++ L ++ + N + Y+AL+ E LR+
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
Query: 184 LQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPD--T 241
EE ++L+ R + KA+ A N NE+ R +QAR+ +EL +AAK + + + D
Sbjct: 183 TTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEV 242
Query: 242 LGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRR 301
+ D + E + P R+ S + RR
Sbjct: 243 IVDETSDHTEETS------------------PVRAISRAAT-----------------RR 267
Query: 302 GHSIGGAPEQRYQIIPVC-VAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLI 360
S P+ P R+P A V DAH EVNAV+F P S LLATGG DR +
Sbjct: 268 SVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRV 327
Query: 361 HLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSG 420
LW V G + E +L G+ ITS++FD +G +LAA+ + A+++W V + + + TL+G
Sbjct: 328 KLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTG 387
Query: 421 HKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGH 480
H KV +AKF L + V+GS DRT+K WDL C +T+ S CND+VC + ++SGH
Sbjct: 388 HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGH 447
Query: 481 NDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVF 540
D+KIRFWD R + + + G++T+L L+ ++ LLSCSRD+ LKVIDLR + I+Q F
Sbjct: 448 FDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTF 507
Query: 541 RADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC 600
A GFKCGSDWT+ VFSPD SY AGS +G+LYIW V TGK+E L H +++NAVAW
Sbjct: 508 SAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWS 567
Query: 601 YSGSHMVSVDQGRKVVLW 618
SGSH+VSVD+G K VLW
Sbjct: 568 PSGSHVVSVDKGCKAVLW 585
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 122 bits (305), Expect = 1e-27
Identities = 92/309 (29%), Positives = 146/309 (47%), Gaps = 13/309 (4%)
Query: 317 PVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTL 376
P C + + P +L H EV +F PN S LA+ G DRLI LWNV G + TL
Sbjct: 50 PRCSSLQAPIM---LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-CDNYATL 105
Query: 377 EGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQ 436
+G G++ + ++ G + +A+ ++ +W + + L GH V + Q
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
Query: 437 AV-TGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGD--HIIISGHNDQKIRFWDSRGP 493
V TGS D TVK WD+ + +T V D IISG D I+ WD R
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 494 HCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLR----VSNIRQVFRADGFKCG 548
T + VT LSLS + +LLS + DNT++V D+R ++F+ +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 549 SDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVS 608
+ + +SPD S AGS D +Y+WD + ++ +L G H ++N VA+ ++S
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG-HAGSINEVAFHPDEPIIIS 344
Query: 609 VDQGRKVVL 617
+++ +
Sbjct: 345 ASSDKRLYM 353
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 113 bits (282), Expect = 6e-25
Identities = 83/296 (28%), Positives = 143/296 (48%), Gaps = 15/296 (5%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H V++V+F PN LA+ ADRLI +W + E +TL G I+ V +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE--KTLYGHNLEISDVAWSSD 94
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
++++A+ ++ +LW V + +TL GH + V F + ++GS D TVK W++
Sbjct: 95 SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Query: 452 GRAYCSRTINVLSYCNDVV---CGDHIIISGHNDQKIRFWDSRGPHC--TQVIPVQGRVT 506
C +T++ S V C +I+SG D R WD+ C T V V+
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 507 SLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFS-PDRSYALA 565
+ S + ++L+ + DNTLK+ D S R + G K A FS + ++
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWD--YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 566 GSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMV---SVDQGRKVVLW 618
GS D +YIW++ T ++ +LQG ++A C+ +++ +++ + + LW
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAA--CHPTENLIASAALENDKTIKLW 326
Score = 72.8 bits (177), Expect = 9e-13
Identities = 55/252 (21%), Positives = 110/252 (43%), Gaps = 13/252 (5%)
Query: 375 TLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTR 434
TL G +++SV F P+G + +++ ++ +W + + ++TL GH +++ +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 435 HQAVTGSRDRTVKEWDLGRAYCSRTINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSR 491
+ V+ S D+T+K WD+ C +T+ S +C + ++IISG D+ ++ W+ +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 492 GPHCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
C + + V+++ + ++S S D ++ D + D
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDD---NPP 212
Query: 551 WTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQG----PHCAAVNAVAWCYSGSHM 606
+ FSP+ Y L + D L +WD G+ G +C N G +
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSV--TGGKWI 270
Query: 607 VSVDQGRKVVLW 618
VS + V +W
Sbjct: 271 VSGSEDNLVYIW 282
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/211 (25%), Positives = 89/211 (42%), Gaps = 9/211 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H + V F P S+L+ +G D + +W V + +TL +++V F+ S
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK--CLKTLSAHSDPVSAVHFNCS 178
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETL-SGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
G +++ +Y+ ++W Q +TL V+ KF +T + D T+K WD
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 451 LGRAYCSRTINVLS---YC---NDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGR 504
R C +T YC N V G I+SG D + W+ + Q +
Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 298
Query: 505 VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSN 535
V + H +L++ + K I L +SN
Sbjct: 299 VVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/239 (21%), Positives = 101/239 (42%), Gaps = 18/239 (7%)
Query: 389 DPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKE 448
D L+++ NQ+ ++ + K TL GH + V++ KF + S DR +
Sbjct: 8 DAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
Query: 449 WDLGRAYCSRT-------INVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPV 501
W +T I+ +++ +D ++S +D+ ++ WD R C + +
Sbjct: 68 WGAYDGKYEKTLYGHNLEISDVAWSSD----SSRLVSASDDKTLKLWDVRSGKCLKTLKG 123
Query: 502 QGR-VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPD 559
V + + ++S S D T+K+ +++ + A SD AV F+
Sbjct: 124 HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAH-----SDPVSAVHFNCS 178
Query: 560 RSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
S ++GS DG IWD +G+ L V+ V + +G ++++ + LW
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (259), Expect = 3e-22
Identities = 79/300 (26%), Positives = 142/300 (47%), Gaps = 21/300 (7%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H V++V+F PN LA+ AD+LI +W + E +T+ G I+ V +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSD 98
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
+++A+ ++ ++W V + +TL GH + V F + V+GS D +V+ WD+
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 452 GRAYCSRTINVLSYCNDVVCGDH------IIISGHNDQKIRFWDSRGPHC--TQVIPVQG 503
C +T+ S D V H +I+S D R WD+ C T +
Sbjct: 159 KTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 504 RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFS-PDRSY 562
V+ + S + ++L+ + DNTLK+ D + + G K A FS +
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY--TGHKNEKYCIFANFSVTGGKW 273
Query: 563 ALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMV---SVDQGRKVVLWQ 619
++GS D +YIW++ T ++ +LQG H V + A C+ +++ +++ + + LW+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQG-HTDVVISTA-CHPTENIIASAALENDKTIKLWK 331
Score = 90.1 bits (222), Expect = 5e-18
Identities = 61/252 (24%), Positives = 115/252 (45%), Gaps = 13/252 (5%)
Query: 375 TLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTR 434
TL G +++SV F P+G + +++ ++ ++W + + ++T+SGHK ++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 435 HQAVTGSRDRTVKEWDLGRAYCSRTINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSR 491
+ V+ S D+T+K WD+ C +T+ S +C + ++I+SG D+ +R WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 492 GPHCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
C + +P V+++ + D ++S S D ++ D + D
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD---NPP 216
Query: 551 WTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQG----PHCAAVNAVAWCYSGSHM 606
+ FSP+ Y LA + D L +WD GK G +C N G +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--TGGKWI 274
Query: 607 VSVDQGRKVVLW 618
VS + V +W
Sbjct: 275 VSGSEDNLVYIW 286
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (259), Expect = 3e-22
Identities = 79/300 (26%), Positives = 142/300 (47%), Gaps = 21/300 (7%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H V++V+F PN LA+ AD+LI +W + E +T+ G I+ V +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSD 98
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
+++A+ ++ ++W V + +TL GH + V F + V+GS D +V+ WD+
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 452 GRAYCSRTINVLSYCNDVVCGDH------IIISGHNDQKIRFWDSRGPHC--TQVIPVQG 503
C +T+ S D V H +I+S D R WD+ C T +
Sbjct: 159 KTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 504 RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFS-PDRSY 562
V+ + S + ++L+ + DNTLK+ D + + G K A FS +
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY--TGHKNEKYCIFANFSVTGGKW 273
Query: 563 ALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMV---SVDQGRKVVLWQ 619
++GS D +YIW++ T ++ +LQG H V + A C+ +++ +++ + + LW+
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQG-HTDVVISTA-CHPTENIIASAALENDKTIKLWK 331
Score = 90.1 bits (222), Expect = 5e-18
Identities = 61/252 (24%), Positives = 115/252 (45%), Gaps = 13/252 (5%)
Query: 375 TLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTR 434
TL G +++SV F P+G + +++ ++ ++W + + ++T+SGHK ++ +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 435 HQAVTGSRDRTVKEWDLGRAYCSRTINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSR 491
+ V+ S D+T+K WD+ C +T+ S +C + ++I+SG D+ +R WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 492 GPHCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
C + +P V+++ + D ++S S D ++ D + D
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD---NPP 216
Query: 551 WTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQG----PHCAAVNAVAWCYSGSHM 606
+ FSP+ Y LA + D L +WD GK G +C N G +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--TGGKWI 274
Query: 607 VSVDQGRKVVLW 618
VS + V +W
Sbjct: 275 VSGSEDNLVYIW 286
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 100 bits (249), Expect = 4e-21
Identities = 74/304 (24%), Positives = 127/304 (41%), Gaps = 30/304 (9%)
Query: 330 DVLDAHLSEVNAVRFG-PNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDF 388
+ L+ H + V A+ F P +ATG D+ LW+V + T G I + F
Sbjct: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--CYHTFRGHTAEIVCLSF 185
Query: 389 DPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKE 448
+P V + + A+LW + + TL GH ++ + F + + +TGS D TV
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245
Query: 449 WDLGRAYCSRTINVL-SYCNDVVCGD-----HIIISGHNDQKIRFWDSRGPHCTQVIPVQ 502
WD A R +N+L +C ++ +I++G D+ + WD+ C +
Sbjct: 246 WD---ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL--- 299
Query: 503 GRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKC-------GSDWTKAV 555
HD L SC + ++F A KC + +K
Sbjct: 300 -------TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 556 FSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKV 615
F+P ++ L GS D IWD TG+ L+G H + + A+ Y G+ +++ +
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG-HTDEIFSCAFNYKGNIVITGSKDNTC 411
Query: 616 VLWQ 619
+W+
Sbjct: 412 RIWR 415
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/168 (25%), Positives = 75/168 (44%), Gaps = 11/168 (6%)
Query: 327 RAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSV 386
R ++L H +E+++ F + SL+ TG D+ LW+ + A TL G I
Sbjct: 252 RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA--TLTGHDDEILDS 309
Query: 387 DFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTV 446
FD +G + A+ + A+++ + L GH+ +++ F + +TGS D+T
Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 447 KEWDLGRAYCSRTINVLSYCNDVVCG------DHIIISGHNDQKIRFW 488
+ WD C + VL D + +I+I+G D R W
Sbjct: 370 RIWDAQTGQC---LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 66.2 bits (160), Expect = 8e-11
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 13/213 (6%)
Query: 383 ITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAV-TGS 441
+T+V + SG + +Y++ +LW + TL GH++ V A F + TGS
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 442 RDRTVKEWDLGRAYCSRTINVLSYCNDVVC-----GDHIIISGHNDQKIRFWD-SRGPHC 495
D+T K W + C T + ++VC ++ +G D + WD G
Sbjct: 155 FDKTCKLWSVETGKCYHTFR--GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEV 212
Query: 496 TQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV 555
+ + SLS + +++ S D+T+ V D R+V G C ++ + A
Sbjct: 213 YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG--RKVNILIG-HC-AEISSAS 268
Query: 556 FSPDRSYALAGSCDGALYIWDVDTGKLESRLQG 588
F+ D S L GS D +WD GK + L G
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTG 301
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 89.0 bits (219), Expect = 1e-17
Identities = 70/291 (24%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H V V F N+ LA+G D + +W++ T G ++T V+F PSG+
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 75
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
+ + + ++ ++W H V + F VT S D+TVK W R
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 455 YCSRTINVLSYCNDVVCG-----DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGR-VTSL 508
++ + N V C +I+S +D+ ++ WD C G VT +
Sbjct: 136 --KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 509 SLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSC 568
+ + DNT+KV D+R + Q ++ F P +Y + S
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLITASS 249
Query: 569 DGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
D L I D+ G+L L G H VA+ +G + S +V++W+
Sbjct: 250 DSTLKILDLMEGRLLYTLHG-HQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 57.0 bits (136), Expect = 5e-08
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 7/163 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H++ V +F P+ L+ + D+ + LW+ S E + GG +T VDF PS
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK--SSRECVHSYCEHGGFVTYVDFHPS 198
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G + AA + ++W V + + H V F + + +T S D T+K DL
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 452 GRAYCSRTINVLSYCNDVVC----GDHIIISGHNDQKIRFWDS 490
T++ V G++ SG +D+++ W S
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFSRTGEY-FASGGSDEQVMVWKS 300
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/245 (20%), Positives = 86/245 (35%), Gaps = 44/245 (17%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 390
V AH + V +V F + T D+ + +W R + +L + F P
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 391 SGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
G +++A+ ++ +LW + + H VT F + D TVK WD
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 451 LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSL 510
+ RT +L + H+ V LS
Sbjct: 216 V------RTHRLLQH-----------YQLHS---------------------AAVNGLSF 237
Query: 511 SHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDG 570
+L++ S D+TLK++DL R ++ G + T FS Y +G D
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEG--RLLYTLHGHQ--GPATTVAFSRTGEYFASGGSDE 293
Query: 571 ALYIW 575
+ +W
Sbjct: 294 QVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 89.0 bits (219), Expect = 1e-17
Identities = 70/291 (24%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H V V F N+ LA+G D + +W++ T G ++T V+F PSG+
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 75
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
+ + + ++ ++W H V + F VT S D+TVK W R
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 455 YCSRTINVLSYCNDVVCG-----DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGR-VTSL 508
++ + N V C +I+S +D+ ++ WD C G VT +
Sbjct: 136 --KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 509 SLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSC 568
+ + DNT+KV D+R + Q ++ F P +Y + S
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG----LSFHPSGNYLITASS 249
Query: 569 DGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
D L I D+ G+L L G H VA+ +G + S +V++W+
Sbjct: 250 DSTLKILDLMEGRLLYTLHG-HQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 57.0 bits (136), Expect = 5e-08
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 7/163 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H++ V +F P+ L+ + D+ + LW+ S E + GG +T VDF PS
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK--SSRECVHSYCEHGGFVTYVDFHPS 198
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G + AA + ++W V + + H V F + + +T S D T+K DL
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 452 GRAYCSRTINVLSYCNDVVC----GDHIIISGHNDQKIRFWDS 490
T++ V G++ SG +D+++ W S
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFSRTGEY-FASGGSDEQVMVWKS 300
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/245 (20%), Positives = 86/245 (35%), Gaps = 44/245 (17%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 390
V AH + V +V F + T D+ + +W R + +L + F P
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 391 SGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
G +++A+ ++ +LW + + H VT F + D TVK WD
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 451 LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSL 510
+ RT +L + H+ V LS
Sbjct: 216 V------RTHRLLQH-----------YQLHS---------------------AAVNGLSF 237
Query: 511 SHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDG 570
+L++ S D+TLK++DL R ++ G + T FS Y +G D
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEG--RLLYTLHGHQ--GPATTVAFSRTGEYFASGGSDE 293
Query: 571 ALYIW 575
+ +W
Sbjct: 294 QVMVW 298
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/291 (24%), Positives = 118/291 (40%), Gaps = 15/291 (5%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H + + ++ PN LAT D + LWN G +TSV F P G
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV--GHKDVVTSVQFSPHGNL 74
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
+ +A+ ++ +LW + H V + F T S D+++K W + R
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 455 YCSRTINVLSY---CNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQ-GRVTSLSL 510
++ ++ C +I+S D+ I+ WD+ C G +
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDF 194
Query: 511 SHDQLHLLSCSRDNTLKVIDLRVSNIRQVFR--ADGFKCGSDWTKAVFSPDRSYALAGSC 568
+ + S D T+KV D+RV+ + Q ++ + G C S F P +Y + S
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS------FHPSGNYLITASS 248
Query: 569 DGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
DG L I D+ G+L LQG H V V++ G S +V+LW+
Sbjct: 249 DGTLKILDLLEGRLIYTLQG-HTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 79.3 bits (194), Expect = 9e-15
Identities = 65/255 (25%), Positives = 110/255 (43%), Gaps = 10/255 (3%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H V +V+F P+ +LLA+ DR + LW + + + + SVDF G
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
+ A+ +++ ++W + + +L H V AKF V+ S D+T+K WD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
Query: 455 YCSRTI-NVLSYCN--DVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPV-QGRVTSLSL 510
C + + + N D I S +DQ ++ WD R Q V G V +S
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
Query: 511 SHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDG 570
+L++ S D TLK++DL R ++ G G +T + FS +G D
Sbjct: 237 HPSGNYLITASSDGTLKILDLLEG--RLIYTLQG-HTGPVFTVS-FSKGGELFASGGADT 292
Query: 571 ALYIWDVDTGKLESR 585
+ +W + +L +
Sbjct: 293 QVLLWRTNFDELHCK 307
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/118 (22%), Positives = 47/118 (39%), Gaps = 2/118 (1%)
Query: 334 AHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGY 393
AH + V +V F + LAT D+ I +W++ R +L + F P G
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF--LYSLYRHTHWVRCAKFSPDGR 157
Query: 394 QVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
+++ + ++ ++W Q S F + + D+TVK WD+
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 84.7 bits (208), Expect = 2e-16
Identities = 65/249 (26%), Positives = 107/249 (42%), Gaps = 22/249 (8%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H V RF P+ L A+ D + LW+V +R + + L+G S+ +V F P
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV--ARAKCLRVLKGHQRSVETVSFSPD 116
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
Q+ + +++ LW V Q L GH+D + ++ F T + TGS D TV WDL
Sbjct: 117 SRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Query: 452 --------GRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQG 503
+A + N+ C ++ SG D+ I W + + +I ++G
Sbjct: 177 RMVTPAVSHQALEGHSANISCLC---YSASGLLASGSWDKTIHIW--KPTTSSLLIQLKG 231
Query: 504 RVT---SLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDR 560
VT S++ S D+L L S +KV D + + + F+PD
Sbjct: 232 HVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHT----CAFTPDG 287
Query: 561 SYALAGSCD 569
++G+ D
Sbjct: 288 KILVSGAAD 296
Score = 79.0 bits (193), Expect = 1e-14
Identities = 78/311 (25%), Positives = 124/311 (39%), Gaps = 27/311 (8%)
Query: 320 VAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGA 379
V A L R H EVN+ F P+ +L TG D ++ W +L L G
Sbjct: 5 VPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL--LWRLGGH 62
Query: 380 GGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVT 439
G + F P G+ +A+ + +LW V A+ L GH+ V F Q +
Sbjct: 63 TGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS 122
Query: 440 GSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGD-----HIIISGHNDQKIRFWDSRGPH 494
G D+ V WD+ R + + + + + D + + +G D + WD R
Sbjct: 123 GGWDKRVMLWDVQSGQMLRLL--VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR--M 178
Query: 495 CTQVIPVQ------GRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCG 548
T + Q ++ L S L L S S D T+ + S++ K
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSL-----LIQLKGH 232
Query: 549 SDWTKAV-FSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMV 607
W K++ FSPD + + + +WD +TGK L+G A + A+ G +V
Sbjct: 233 VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA-HTCAFTPDGKILV 291
Query: 608 S--VDQGRKVV 616
S DQ R+ +
Sbjct: 292 SGAADQTRRQI 302
Score = 67.4 bits (163), Expect = 4e-11
Identities = 59/247 (23%), Positives = 98/247 (39%), Gaps = 15/247 (6%)
Query: 380 GGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVT 439
GG + S F P G +L + + W+ Q L GH V +F H +
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFAS 80
Query: 440 GSRDRTVKEWDLGRAYC-------SRTINVLSYCNDVVCGDHIIISGHNDQKIRFWD-SR 491
S D TV+ WD+ RA C R++ +S+ D + SG D+++ WD
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD----SRQLASGGWDKRVMLWDVQS 136
Query: 492 GPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDW 551
G ++ + + S S L + S D+T+ + DLR+ + + S
Sbjct: 137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM--VTPAVSHQALEGHSAN 194
Query: 552 TKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQ 611
+ +GS D ++IW T L +L+G H V ++A+ + S
Sbjct: 195 ISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKG-HVTWVKSIAFSPDELWLASAGY 253
Query: 612 GRKVVLW 618
R V +W
Sbjct: 254 SRMVKVW 260
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 84.0 bits (206), Expect = 4e-16
Identities = 82/310 (26%), Positives = 133/310 (42%), Gaps = 22/310 (7%)
Query: 324 LPTRAQDVLDAHLSEVNAVRFGPNSS-LLATGGADRLIHLWNVVGSRLEANQTLEGAGGS 382
LP + V H V+AVR P S LL + D I LW V G R +T G +
Sbjct: 276 LPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER-RCLRTFIGHSKA 334
Query: 383 ITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQA---VT 439
+ + F+ +G Q L+A Y++ +LW Q + K KF + V
Sbjct: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-CVKFNPDEDKQNLFVA 393
Query: 440 GSRDRTVKEWDLGRAYCSRTINV-LSYCNDVVCGDHI--IISGHNDQKIRFWDSRGPHCT 496
G D+ + +WD+ + + L N +V D +S +D+ +R W+ P
Sbjct: 394 GMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDF 453
Query: 497 QVI--PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVS---NIRQVFRAD---GFKCG 548
+ I P + +++LS + L S DN + + + N +++F+ G+ C
Sbjct: 454 KYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQ 513
Query: 549 SDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVS 608
D FSPD SY ++G +G L IWD T KL SR + + AV + S +++
Sbjct: 514 VD-----FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVIT 568
Query: 609 VDQGRKVVLW 618
+ LW
Sbjct: 569 CGWDGLIKLW 578
Score = 36.2 bits (82), Expect = 0.092
Identities = 34/157 (21%), Positives = 62/157 (39%), Gaps = 23/157 (14%)
Query: 474 HIIISGHNDQKIRFWDSRGPH-CTQVIPVQGR-VTSLSLSHDQLHLLSCSRDNTLKVIDL 531
H+++S D KI+ W+ G C + + V + + LS + D LK+ D
Sbjct: 302 HLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDT 361
Query: 532 RVSNIRQVFRADGFKCGSDWTK------AVFSPD---RSYALAGSCDGALYIWDVDTGKL 582
+C S +T F+PD ++ +AG D + WD+ +G++
Sbjct: 362 ETG-----------QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI 410
Query: 583 ESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
H AVN + + VS + + +W+
Sbjct: 411 VQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 80.9 bits (198), Expect = 3e-15
Identities = 80/346 (23%), Positives = 133/346 (38%), Gaps = 55/346 (15%)
Query: 323 RLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGS 382
R TR L+ H V +V F P LA+G D + W++ S + T +G
Sbjct: 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL--STETPHFTCKGHRHW 158
Query: 383 ITSVDFDPSGYQVLAATYNQAAQLWKVGEA-QSKETLSGHKDKVTAAKFKLTR-----HQ 436
+ S+ + P G ++ + N LW Q TL+GH +T ++
Sbjct: 159 VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRY 218
Query: 437 AVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVC----GDHIIISGHNDQKIRFWDSRG 492
+ S+D +V+ WD C R + + V C GD ++ S D+ I+ W +
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILT--GHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHD 276
Query: 493 PHCTQVIPVQGR-VTSLSLSHD-----------QLHLLSCSRDNTLKVIDLRVSNIRQVF 540
+ + G V +++LS D + + +L+ + R + +
Sbjct: 277 GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 541 RADG---FKCGSD------WTKA-------------------VFSPDRSYALAGSCDGAL 572
R G GSD W+ A +FSPD + S D ++
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 573 YIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
+WD TGK + L+G H AAV +AW +VS + +W
Sbjct: 397 KLWDGRTGKYLASLRG-HVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 50.8 bits (120), Expect = 4e-06
Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 17/153 (11%)
Query: 476 IISGHNDQKIRFWD--SRGPHCTQVIPVQGR---VTSLSLSHDQLHLLSCSRDNTLKVID 530
+ SG D +RFWD + PH T +G V S+S S D L S ++ + + D
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFT----CKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Query: 531 LRVSNIRQVFRA----DGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRL 586
S +QV R + G W +P+ Y + S DG++ IWD G+ E L
Sbjct: 185 --PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERIL 242
Query: 587 QGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
G H +V + W G + S Q R + +W+
Sbjct: 243 TG-HTQSVTCLRWGGDGL-LYSASQDRTIKVWR 273
Score = 49.7 bits (117), Expect = 8e-06
Identities = 40/165 (24%), Positives = 71/165 (43%), Gaps = 9/165 (5%)
Query: 329 QDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDF 388
Q++ + LS N VR G L +G D + LW+ + + + G I V F
Sbjct: 323 QELKERALSRYNLVR-GQGPERLVSGSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLF 380
Query: 389 DPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKE 448
P V +A+++++ +LW + +L GH V + V+GS D T+K
Sbjct: 381 SPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV 440
Query: 449 WDLGRAYCSRTINVLSYCNDVVCGD-----HIIISGHNDQKIRFW 488
WD+ +++ + ++V D + SG D+ +R W
Sbjct: 441 WDVKAQ--KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 79.7 bits (195), Expect = 7e-15
Identities = 67/252 (26%), Positives = 102/252 (40%), Gaps = 24/252 (9%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLW--NVVGSRLEANQTLEGAGGSITSVDFDPSG 392
H V V F P+ LLA+G D+ + +W NV G + ++ SV F G
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE----STVFRAHTATVRSVHFCSDG 77
Query: 393 YQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLG 452
+ A+ ++ ++W + +LS H + V AKF V+ S D+TVK WD
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 453 RAYCSRTINVLSYCN--------DVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPV-QG 503
C V SYC D I + D ++ WD R Q +
Sbjct: 138 SREC-----VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 504 RVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYA 563
V LS +L++ S D+TLK++DL R ++ G + T FS Y
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEG--RLLYTLHGHQ--GPATTVAFSRTGEYF 248
Query: 564 LAGSCDGALYIW 575
+G D + +W
Sbjct: 249 ASGGSDEQVMVW 260
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/248 (23%), Positives = 100/248 (40%), Gaps = 13/248 (5%)
Query: 378 GAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQA 437
G ++T V+F PSG+ + + + ++ ++W H V + F
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 438 VTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCG-----DHIIISGHNDQKIRFWDSRG 492
VT S D+TVK W R ++ + N V C +I+S +D+ ++ WD
Sbjct: 81 VTASDDKTVKVWATHRQ--KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138
Query: 493 PHCTQVIPVQGR-VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDW 551
C G VT + + + DNT+KV D+R + Q ++
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG-- 196
Query: 552 TKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQ 611
F P +Y + S D L I D+ G+L L G H VA+ +G + S
Sbjct: 197 --LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG-HQGPATTVAFSRTGEYFASGGS 253
Query: 612 GRKVVLWQ 619
+V++W+
Sbjct: 254 DEQVMVWK 261
Score = 57.0 bits (136), Expect = 5e-08
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 7/163 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H++ V +F P+ L+ + D+ + LW+ S E + GG +T VDF PS
Sbjct: 103 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK--SSRECVHSYCEHGGFVTYVDFHPS 160
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G + AA + ++W V + + H V F + + +T S D T+K DL
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
Query: 452 GRAYCSRTINVLSYCNDVVC----GDHIIISGHNDQKIRFWDS 490
T++ V G++ SG +D+++ W S
Sbjct: 221 MEGRLLYTLHGHQGPATTVAFSRTGEY-FASGGSDEQVMVWKS 262
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 79.7 bits (195), Expect = 7e-15
Identities = 42/125 (33%), Positives = 62/125 (49%), Gaps = 2/125 (1%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 390
+ HL++VN RF PNS+ +ATG ADR + LW+V+ + G G I S+ F P
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV--RIFTGHKGPIHSLTFSP 679
Query: 391 SGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
+G + + LW +G L GH D V + +F +GS D TV+ WD
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Query: 451 LGRAY 455
+A+
Sbjct: 740 AIKAF 744
Score = 71.2 bits (173), Expect = 3e-12
Identities = 57/213 (26%), Positives = 89/213 (41%), Gaps = 24/213 (11%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGS---ITSVD 387
+L H V F P+ + L + D + LW+ L+ L G G +
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS-----LQTFTCLVGYKGHNYPVWDTQ 592
Query: 388 FDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVK 447
F P GY ++ +++ A+LW Q +GH V +F + TGS DRTV+
Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 448 EWDLGRAYCSR-------TINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIP 500
WD+ C R I+ L++ + + +G D ++ WD H V
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPN----GRFLATGATDGRVLLWDI--GHGLMVGE 706
Query: 501 VQGR---VTSLSLSHDQLHLLSCSRDNTLKVID 530
++G V SL S D L S S DNT+++ D
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 61.6 bits (148), Expect = 2e-09
Identities = 62/286 (21%), Positives = 116/286 (40%), Gaps = 26/286 (9%)
Query: 339 VNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAA 398
+ AV +SSL+A G AD + +W+V +L + + ++ +D +
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQ----ASDLSLIDKESDDVLERIM 528
Query: 399 TYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCS- 457
A++L + L GH V A F R+ ++ S D TV+ W L C
Sbjct: 529 DEKTASEL---------KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 458 --RTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSH--- 512
+ N + + +SG +D+ R W + H + G + ++ +
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT--DHYQPLRIFAGHLADVNCTRFHP 637
Query: 513 DQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGAL 572
+ ++ + S D T+++ D+ N ++F S FSP+ + G+ DG +
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS----LTFSPNGRFLATGATDGRV 693
Query: 573 YIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
+WD+ G + L+G H V ++ + G + S V LW
Sbjct: 694 LLWDIGHGLMVGELKG-HTDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 79.7 bits (195), Expect = 7e-15
Identities = 39/123 (31%), Positives = 65/123 (52%), Gaps = 2/123 (1%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
HL++V+ V+F PNS+ LATG D+ + LW+ + + + G G + S+ F P+G
Sbjct: 425 HLADVDCVKFHPNSNYLATGSTDKTVRLWSA--QQGNSVRLFTGHRGPVLSLAFSPNGKY 482
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
+ +A +Q +LW + + L GH D +T+ F + S D +V+ WD+
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Query: 455 YCS 457
YCS
Sbjct: 543 YCS 545
Score = 68.9 bits (167), Expect = 1e-11
Identities = 60/275 (21%), Positives = 104/275 (37%), Gaps = 42/275 (15%)
Query: 339 VNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEAN------------------------- 373
+N P+S LLA G + I LW++ +L++
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
Query: 374 -----QTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAA 428
+ L G G + S F +L+ + + + + W +G + GH V
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
Query: 429 KFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVC-----GDHIIISGHNDQ 483
+GS DRT + W R Y R + DV C + + +G D+
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIY--AGHLADVDCVKFHPNSNYLATGSTDK 448
Query: 484 KIRFWDSRGPHCTQVIPV-QGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRA 542
+R W ++ + ++ +G V SL+ S + +L S D LK+ DL + + R
Sbjct: 449 TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRG 508
Query: 543 DGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDV 577
+ T FSPD + S D ++ +WD+
Sbjct: 509 HT----DNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 64.3 bits (155), Expect = 3e-10
Identities = 51/208 (24%), Positives = 85/208 (40%), Gaps = 10/208 (4%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 390
+L H V + RF +SS L + D I W++ +G + +D P
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISP 394
Query: 391 SGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
+ ++++ A+LW +GH V KF + TGS D+TV+ W
Sbjct: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
Query: 451 LGRAYCSRTIN-----VLSYCNDVVCGDHIIISGHNDQKIRFWD-SRGPHCTQVIPVQGR 504
+ R VLS + S DQ+++ WD + G ++
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSP--NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 512
Query: 505 VTSLSLSHDQLHLLSCSRDNTLKVIDLR 532
+TSL+ S D + S S DN+++V D+R
Sbjct: 513 ITSLTFSPDSGLIASASMDNSVRVWDIR 540
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/275 (23%), Positives = 121/275 (44%), Gaps = 26/275 (9%)
Query: 351 LATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVG 410
+ +G D + +W+ V + +TL G G + S + +++ + ++ ++W
Sbjct: 276 IVSGSDDNTLKVWSAVTGK--CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 331
Query: 411 EAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVV 470
+ TL GH V L + V+GSRD T++ WD+ C + + + V
Sbjct: 332 TGECIHTLYGHTSTVRC--MHLHEKRVVSGSRDATLRVWDIETGQCLHVL--MGHVAAVR 387
Query: 471 CGDHI---IISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSL-SLSHDQLHLLSCSRDNTL 526
C + ++SG D ++ WD C + QG + SL D +H++S S D ++
Sbjct: 388 CVQYDGRRVVSGAYDFMVKVWDPETETCLHTL--QGHTNRVYSLQFDGIHVVSGSLDTSI 445
Query: 527 KVIDLRVSN-IRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESR 585
+V D+ N I + G + + ++G+ D + IWD+ TG+
Sbjct: 446 RVWDVETGNCIHTLTGHQSLTSGMELKDNIL-------VSGNADSTVKIWDIKTGQCLQT 498
Query: 586 LQGP--HCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQGP H +AV + ++ + +++ V LW
Sbjct: 499 LQGPNKHQSAVTCLQ--FNKNFVITSSDDGTVKLW 531
Score = 70.5 bits (171), Expect = 4e-12
Identities = 62/255 (24%), Positives = 108/255 (42%), Gaps = 17/255 (6%)
Query: 349 SLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWK 408
+++ +G DR + +WN E TL G ++ + +V++ + + ++W
Sbjct: 314 NIIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWD 369
Query: 409 VGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCND 468
+ Q L GH V ++ R V+G+ D VK WD C T+ + N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQ--GHTNR 425
Query: 469 VVC----GDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDN 524
V G H++ SG D IR WD +C + +TS D + L+S + D+
Sbjct: 426 VYSLQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-LVSGNADS 483
Query: 525 TLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLES 584
T+K+ D++ Q + K S T F+ +++ + S DG + +WD+ TG+
Sbjct: 484 TVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIR 540
Query: 585 RLQGPHCAAVNAVAW 599
L V W
Sbjct: 541 NLVTLESGGSGGVVW 555
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/216 (26%), Positives = 95/216 (43%), Gaps = 18/216 (8%)
Query: 407 WKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYC 466
W+ GE +S + L GH D V + ++ V+GS D T+K W C RT+ + +
Sbjct: 247 WRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL--VGHT 303
Query: 467 NDVVCG---DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSH-DQLHLLSCSR 522
V D+IIISG D+ ++ W++ C + G +++ H + ++S SR
Sbjct: 304 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL--YGHTSTVRCMHLHEKRVVSGSR 361
Query: 523 DNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKL 582
D TL+V D+ V G D ++G+ D + +WD +T
Sbjct: 362 DATLRVWDIETGQCLHVL------MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 415
Query: 583 ESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQG H V ++ + G H+VS + +W
Sbjct: 416 LHTLQG-HTNRVYSLQ--FDGIHVVSGSLDTSIRVW 448
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/275 (23%), Positives = 121/275 (44%), Gaps = 26/275 (9%)
Query: 351 LATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVG 410
+ +G D + +W+ V + +TL G G + S + +++ + ++ ++W
Sbjct: 394 IVSGSDDNTLKVWSAVTGK--CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 411 EAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVV 470
+ TL GH V L + V+GSRD T++ WD+ C + + + V
Sbjct: 450 TGECIHTLYGHTSTVRC--MHLHEKRVVSGSRDATLRVWDIETGQCLHVL--MGHVAAVR 505
Query: 471 CGDHI---IISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSL-SLSHDQLHLLSCSRDNTL 526
C + ++SG D ++ WD C + QG + SL D +H++S S D ++
Sbjct: 506 CVQYDGRRVVSGAYDFMVKVWDPETETCLHTL--QGHTNRVYSLQFDGIHVVSGSLDTSI 563
Query: 527 KVIDLRVSN-IRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESR 585
+V D+ N I + G + + ++G+ D + IWD+ TG+
Sbjct: 564 RVWDVETGNCIHTLTGHQSLTSGMELKDNIL-------VSGNADSTVKIWDIKTGQCLQT 616
Query: 586 LQGP--HCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQGP H +AV + ++ + +++ V LW
Sbjct: 617 LQGPNKHQSAVTCLQ--FNKNFVITSSDDGTVKLW 649
Score = 70.5 bits (171), Expect = 4e-12
Identities = 62/255 (24%), Positives = 108/255 (42%), Gaps = 17/255 (6%)
Query: 349 SLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWK 408
+++ +G DR + +WN E TL G ++ + +V++ + + ++W
Sbjct: 432 NIIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWD 487
Query: 409 VGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCND 468
+ Q L GH V ++ R V+G+ D VK WD C T+ + N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQ--GHTNR 543
Query: 469 VVC----GDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDN 524
V G H++ SG D IR WD +C + +TS D + L+S + D+
Sbjct: 544 VYSLQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-LVSGNADS 601
Query: 525 TLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLES 584
T+K+ D++ Q + K S T F+ +++ + S DG + +WD+ TG+
Sbjct: 602 TVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIR 658
Query: 585 RLQGPHCAAVNAVAW 599
L V W
Sbjct: 659 NLVTLESGGSGGVVW 673
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/216 (26%), Positives = 95/216 (43%), Gaps = 18/216 (8%)
Query: 407 WKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYC 466
W+ GE +S + L GH D V + ++ V+GS D T+K W C RT+ + +
Sbjct: 365 WRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL--VGHT 421
Query: 467 NDVVCG---DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSH-DQLHLLSCSR 522
V D+IIISG D+ ++ W++ C + G +++ H + ++S SR
Sbjct: 422 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL--YGHTSTVRCMHLHEKRVVSGSR 479
Query: 523 DNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKL 582
D TL+V D+ V G D ++G+ D + +WD +T
Sbjct: 480 DATLRVWDIETGQCLHVL------MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 533
Query: 583 ESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQG H V ++ + G H+VS + +W
Sbjct: 534 LHTLQG-HTNRVYSLQ--FDGIHVVSGSLDTSIRVW 566
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/275 (23%), Positives = 121/275 (44%), Gaps = 26/275 (9%)
Query: 351 LATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVG 410
+ +G D + +W+ V + +TL G G + S + +++ + ++ ++W
Sbjct: 314 IVSGSDDNTLKVWSAVTGK--CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 369
Query: 411 EAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVV 470
+ TL GH V L + V+GSRD T++ WD+ C + + + V
Sbjct: 370 TGECIHTLYGHTSTVRC--MHLHEKRVVSGSRDATLRVWDIETGQCLHVL--MGHVAAVR 425
Query: 471 CGDHI---IISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSL-SLSHDQLHLLSCSRDNTL 526
C + ++SG D ++ WD C + QG + SL D +H++S S D ++
Sbjct: 426 CVQYDGRRVVSGAYDFMVKVWDPETETCLHTL--QGHTNRVYSLQFDGIHVVSGSLDTSI 483
Query: 527 KVIDLRVSN-IRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESR 585
+V D+ N I + G + + ++G+ D + IWD+ TG+
Sbjct: 484 RVWDVETGNCIHTLTGHQSLTSGMELKDNIL-------VSGNADSTVKIWDIKTGQCLQT 536
Query: 586 LQGP--HCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQGP H +AV + ++ + +++ V LW
Sbjct: 537 LQGPNKHQSAVTCLQ--FNKNFVITSSDDGTVKLW 569
Score = 70.5 bits (171), Expect = 4e-12
Identities = 62/255 (24%), Positives = 108/255 (42%), Gaps = 17/255 (6%)
Query: 349 SLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWK 408
+++ +G DR + +WN E TL G ++ + +V++ + + ++W
Sbjct: 352 NIIISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWD 407
Query: 409 VGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCND 468
+ Q L GH V ++ R V+G+ D VK WD C T+ + N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPETETCLHTLQ--GHTNR 463
Query: 469 VVC----GDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDN 524
V G H++ SG D IR WD +C + +TS D + L+S + D+
Sbjct: 464 VYSLQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI-LVSGNADS 521
Query: 525 TLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLES 584
T+K+ D++ Q + K S T F+ +++ + S DG + +WD+ TG+
Sbjct: 522 TVKIWDIKTGQCLQTLQGPN-KHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIR 578
Query: 585 RLQGPHCAAVNAVAW 599
L V W
Sbjct: 579 NLVTLESGGSGGVVW 593
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/216 (26%), Positives = 95/216 (43%), Gaps = 18/216 (8%)
Query: 407 WKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYC 466
W+ GE +S + L GH D V + ++ V+GS D T+K W C RT+ + +
Sbjct: 285 WRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL--VGHT 341
Query: 467 NDVVCG---DHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSH-DQLHLLSCSR 522
V D+IIISG D+ ++ W++ C + G +++ H + ++S SR
Sbjct: 342 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL--YGHTSTVRCMHLHEKRVVSGSR 399
Query: 523 DNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKL 582
D TL+V D+ V G D ++G+ D + +WD +T
Sbjct: 400 DATLRVWDIETGQCLHVL------MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 453
Query: 583 ESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
LQG H V ++ + G H+VS + +W
Sbjct: 454 LHTLQG-HTNRVYSLQ--FDGIHVVSGSLDTSIRVW 486
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 77.4 bits (189), Expect = 4e-14
Identities = 70/290 (24%), Positives = 116/290 (40%), Gaps = 31/290 (10%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H S V V F P S++ + D I +W+ E +TL+G S+ + FD S
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHS 161
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G + + + + +LW + T+ GH V++ V+ SRD+T+K W++
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 452 GRAYCSRTINVLSYCNDVVCGDH---IIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSL 508
YC +T +V + +I S NDQ +R W C +
Sbjct: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL--------- 272
Query: 509 SLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSC 568
+ H++ C + S+ + A G + TK P + L+GS
Sbjct: 273 ---REHEHVVEC-------ISWAPESSYSSISEATGSE-----TKKSGKPG-PFLLSGSR 316
Query: 569 DGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
D + +WDV TG L G H V V + G ++S + + +W
Sbjct: 317 DKTIKMWDVSTGMCLMTLVG-HDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 73.6 bits (179), Expect = 5e-13
Identities = 59/270 (21%), Positives = 109/270 (40%), Gaps = 32/270 (11%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H V + F + LLA+ AD I LW+ G E +T+ G +++SV P+
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIMPN 203
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G +++A+ ++ ++W+V +T +GH++ V + + S D+TV+ W +
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263
Query: 452 GRAYCSRTINVLSYCNDVVCG-----------------------DHIIISGHNDQKIRFW 488
C + + + + ++SG D+ I+ W
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 489 D-SRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRA-DGFK 546
D S G ++ V + +LSC+ D TL+V D + + A + F
Sbjct: 324 DVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383
Query: 547 CGSDWTKAVFSPDRSYALAGSCDGALYIWD 576
D+ K Y + GS D + +W+
Sbjct: 384 TSLDFHKTA-----PYVVTGSVDQTVKVWE 408
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/197 (25%), Positives = 89/197 (45%), Gaps = 13/197 (6%)
Query: 415 KETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDH 474
K LSGH+ VT F V+ S D T+K WD RT+ + + DH
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 475 ---IIISGHNDQKIRFWDSRGPHCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVID 530
++ S D I+ WD +G C + + V+S+++ + H++S SRD T+K+ +
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 531 LRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSC--DGALYIWDVDTGKLESRLQG 588
++ + F +W + V P++ L SC D + +W V T + ++ L+
Sbjct: 221 VQTGYCVKTFTGH-----REWVRMV-RPNQDGTLIASCSNDQTVRVWVVATKECKAELR- 273
Query: 589 PHCAAVNAVAWCYSGSH 605
H V ++W S+
Sbjct: 274 EHEHVVECISWAPESSY 290
Score = 52.4 bits (124), Expect = 1e-06
Identities = 36/140 (25%), Positives = 64/140 (45%), Gaps = 4/140 (2%)
Query: 311 QRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRL 370
+ ++ + C++ + + +A SE + G L +G D+ I +W+V S
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETK--KSGKPGPFLLSGSRDKTIKMWDV--STG 328
Query: 371 EANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKF 430
TL G + V F G +L+ ++ ++W + +TL+ H+ VT+ F
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDF 388
Query: 431 KLTRHQAVTGSRDRTVKEWD 450
T VTGS D+TVK W+
Sbjct: 389 HKTAPYVVTGSVDQTVKVWE 408
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/179 (20%), Positives = 71/179 (39%), Gaps = 23/179 (12%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEAN-------------------QT 375
H V VR + +L+A+ D+ + +W V +A +
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSS 292
Query: 376 LEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRH 435
+ A GS T P + +L+ + ++ ++W V TL GH + V F
Sbjct: 293 ISEATGSETKKSGKPGPF-LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGK 351
Query: 436 QAVTGSRDRTVKEWDLGRAYCSRTINVLSY---CNDVVCGDHIIISGHNDQKIRFWDSR 491
++ + D+T++ WD C +T+N + D +++G DQ ++ W+ R
Sbjct: 352 FILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 35.4 bits (80), Expect = 0.16
Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Query: 517 LLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSC--DGALYI 574
++S S D T+KV D + + + G + S D S L SC D + +
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLK------GHTDSVQDISFDHSGKLLASCSADMTIKL 176
Query: 575 WDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
WD + + G H V++VA +G H+VS + + + +W+
Sbjct: 177 WDFQGFECIRTMHG-HDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 76.3 bits (186), Expect = 8e-14
Identities = 74/290 (25%), Positives = 120/290 (41%), Gaps = 19/290 (6%)
Query: 339 VNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAA 398
V VR+ P L TG + LWN G L+ + ++ + + +L A
Sbjct: 122 VFVVRWTPEGRRLVTGASSGEFTLWN--GLTFNFETILQAHDSPVRAMTWSHNDMWMLTA 179
Query: 399 TYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSR 458
+ + W+ + + HK+ + A F T ++ T S D TV+ WD R + R
Sbjct: 180 DHGGYVKYWQ-SNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEER 238
Query: 459 TINVLSYCNDVVCGD-----HIIISGHND--QKIRFWDSR-GPHCTQVIPVQGRVTSLSL 510
+ + DV C D +++SG D Q I+FWD + G + + V + L
Sbjct: 239 ILR--GHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKL 296
Query: 511 SHDQLHLLSCSRDNTLKVIDLR-VSNIRQVFRADGFKCGSDWTKAVFSPDRSYALA-GSC 568
+ + LL+ SRD+ K+ D+R + QVFR G K + T + P A G
Sbjct: 297 NLNGNWLLTASRDHLCKLFDIRNLKEELQVFR--GHK--KEATAVAWHPVHEGLFASGGS 352
Query: 569 DGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
DG+L W V K ++ H + ++AW G + S W
Sbjct: 353 DGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/123 (26%), Positives = 54/123 (43%), Gaps = 4/123 (3%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 390
+ AH + F P + AT D + +W+ + R + L G G + VD+ P
Sbjct: 197 MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFL--RCHEERILRGHGADVKCVDWHP 254
Query: 391 SGYQVLAATYN--QAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKE 448
+ V++ + + Q + W QS TL HK+ V K L + +T SRD K
Sbjct: 255 TKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKL 314
Query: 449 WDL 451
+D+
Sbjct: 315 FDI 317
Score = 40.0 bits (92), Expect = 0.006
Identities = 37/175 (21%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 331 VLDAHLSEVNAVRFGPNSSLLATGGAD--RLIHLWNVVGSRLEANQTLEGAGGSITSVDF 388
+L H ++V V + P L+ +G D + I W+ + A TL ++ V
Sbjct: 239 ILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLA--TLHAHKNTVMEVKL 296
Query: 389 DPSGYQVLAATYNQAAQLWKVGEAQSK-ETLSGHKDKVTAAKFKLTRHQAV--TGSRDRT 445
+ +G +L A+ + +L+ + + + + GHK + TA + H+ + +G D +
Sbjct: 297 NLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPV-HEGLFASGGSDGS 355
Query: 446 VKEWDLGRAYCSRTINVLSYCNDVVCGD-------HIIISGHNDQKIRFWDSRGP 493
+ W +G + + + ++ + HI+ SG ND +FW P
Sbjct: 356 LLFWHVG---VEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRP 407
Score = 35.0 bits (79), Expect = 0.20
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Query: 556 FSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKV 615
++P+ + G+ G +W+ T E+ LQ H + V A+ W ++ M++ D G V
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQA-HDSPVRAMTWSHNDMWMLTADHGGYV 185
Query: 616 VLWQ 619
WQ
Sbjct: 186 KYWQ 189
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 75.1 bits (183), Expect = 2e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 10/263 (3%)
Query: 324 LPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSI 383
LP + LD V AVRF + + T G+D+ + LWN + L +T G G +
Sbjct: 13 LPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTL--LRTYSGHGYEV 70
Query: 384 TSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRD 443
+ + ++A LW V Q GH KV +F ++GS D
Sbjct: 71 LDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSID 130
Query: 444 RTVKEWDLGRAYCSRTINVLSYCND----VVCGDHIIISGHNDQKIRFWDSRGPHCTQVI 499
+++ WD R+ + L D V DH I++G D ++R +D R
Sbjct: 131 SSIRCWDC-RSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDY 189
Query: 500 PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPD 559
V +T S D L S D+TL+++D + ++ G K S
Sbjct: 190 -VGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYK--GHKNQEYKLDCCLSER 246
Query: 560 RSYALAGSCDGALYIWDVDTGKL 582
++ ++ S DG ++ WD+ G L
Sbjct: 247 DTHVVSCSEDGKVFFWDLVEGAL 269
Score = 71.6 bits (174), Expect = 2e-12
Identities = 68/257 (26%), Positives = 107/257 (41%), Gaps = 25/257 (9%)
Query: 374 QTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLT 433
+TL+ G++ +V F+ G L ++ +LW T SGH +V A
Sbjct: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
Query: 434 RHQAVTGSRDRTVKEWDLGRAYCSR-------TINVLSYCNDVVCGDHIIISGHNDQKIR 486
+G D+ V WD+ R +N + + + +I+SG D IR
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEAT----VILSGSIDSSIR 134
Query: 487 FWD--SRGPHCTQVI-PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRAD 543
WD SR P Q + + V+S+ +S + +L+ S D ++ DLR+ + +
Sbjct: 135 CWDCRSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYDLRMGQLFSDY--- 189
Query: 544 GFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYS- 602
GS T FS D L S D L + D DTG+L +G H + C S
Sbjct: 190 ---VGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKG-HKNQEYKLDCCLSE 245
Query: 603 -GSHMVSVDQGRKVVLW 618
+H+VS + KV W
Sbjct: 246 RDTHVVSCSEDGKVFFW 262
Score = 40.0 bits (92), Expect = 0.006
Identities = 44/182 (24%), Positives = 73/182 (40%), Gaps = 12/182 (6%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H +VN V+F ++++ +G D I W+ R E QTL+ A ++SV S ++
Sbjct: 108 HAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHE 165
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD---- 450
+LA + + + + + Q G +T F + S D T++ D
Sbjct: 166 ILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTG 223
Query: 451 --LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPV-QGRVTS 507
LG + C H ++S D K+ FWD +PV G V S
Sbjct: 224 ELLGEYKGHKNQEYKLDCCLSERDTH-VVSCSEDGKVFFWDLVEGALALALPVGSGVVQS 282
Query: 508 LS 509
L+
Sbjct: 283 LA 284
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 75.1 bits (183), Expect = 2e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 10/263 (3%)
Query: 324 LPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSI 383
LP + LD V AVRF + + T G+D+ + LWN + L +T G G +
Sbjct: 13 LPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTL--LRTYSGHGYEV 70
Query: 384 TSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRD 443
+ + ++A LW V Q GH KV +F ++GS D
Sbjct: 71 LDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSID 130
Query: 444 RTVKEWDLGRAYCSRTINVLSYCND----VVCGDHIIISGHNDQKIRFWDSRGPHCTQVI 499
+++ WD R+ + L D V DH I++G D ++R +D R
Sbjct: 131 SSIRCWDC-RSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDY 189
Query: 500 PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPD 559
V +T S D L S D+TL+++D + ++ G K S
Sbjct: 190 -VGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYK--GHKNQEYKLDCCLSER 246
Query: 560 RSYALAGSCDGALYIWDVDTGKL 582
++ ++ S DG ++ WD+ G L
Sbjct: 247 DTHVVSCSEDGKVFFWDLVEGAL 269
Score = 71.6 bits (174), Expect = 2e-12
Identities = 68/257 (26%), Positives = 107/257 (41%), Gaps = 25/257 (9%)
Query: 374 QTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLT 433
+TL+ G++ +V F+ G L ++ +LW T SGH +V A
Sbjct: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
Query: 434 RHQAVTGSRDRTVKEWDLGRAYCSR-------TINVLSYCNDVVCGDHIIISGHNDQKIR 486
+G D+ V WD+ R +N + + + +I+SG D IR
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEAT----VILSGSIDSSIR 134
Query: 487 FWD--SRGPHCTQVI-PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRAD 543
WD SR P Q + + V+S+ +S + +L+ S D ++ DLR+ + +
Sbjct: 135 CWDCRSRRPEPVQTLDEARDGVSSVKVSDHE--ILAGSVDGRVRRYDLRMGQLFSDY--- 189
Query: 544 GFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYS- 602
GS T FS D L S D L + D DTG+L +G H + C S
Sbjct: 190 ---VGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKG-HKNQEYKLDCCLSE 245
Query: 603 -GSHMVSVDQGRKVVLW 618
+H+VS + KV W
Sbjct: 246 RDTHVVSCSEDGKVFFW 262
Score = 40.0 bits (92), Expect = 0.006
Identities = 44/182 (24%), Positives = 73/182 (40%), Gaps = 12/182 (6%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H +VN V+F ++++ +G D I W+ R E QTL+ A ++SV S ++
Sbjct: 108 HAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKV--SDHE 165
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD---- 450
+LA + + + + + Q G +T F + S D T++ D
Sbjct: 166 ILAGSVDGRVRRYDLRMGQLFSDYVG--SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTG 223
Query: 451 --LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPV-QGRVTS 507
LG + C H ++S D K+ FWD +PV G V S
Sbjct: 224 ELLGEYKGHKNQEYKLDCCLSERDTH-VVSCSEDGKVFFWDLVEGALALALPVGSGVVQS 282
Query: 508 LS 509
L+
Sbjct: 283 LA 284
>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
Length = 367
Score = 73.2 bits (178), Expect = 7e-13
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 23/277 (8%)
Query: 320 VAARLPTRA-QDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEG 378
+ R+ T+A Q+ AH+ V+ V NS L +GG D+ + +N + + +G
Sbjct: 45 IEERIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVV--KRFKG 101
Query: 379 AGGSITSVDFDPSGYQVLAATYNQAAQLWKV-GEAQSKETLSGHKDKVTAAKFKLTRHQA 437
IT V P Q +A+ ++ +W + G +Q ++ L GH VT Q
Sbjct: 102 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQL 161
Query: 438 VTGSRDRTVKEWD------LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR 491
TGSRD T+ WD + RA SR + V C V + I+ D+ +R WDSR
Sbjct: 162 CTGSRDNTLLLWDVVTGQSVERASVSRNV-VTHLC--WVPREPYILQTSEDKTLRLWDSR 218
Query: 492 GPHCTQVIPVQGRV-TSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
G + P + + T +S D +SCS + + + ++RQ G
Sbjct: 219 GLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHF 278
Query: 551 WTKA--VFSPDRSYAL-----AGSCDGALYIWDVDTG 580
T A VF P R+ AL S D + IW+ DTG
Sbjct: 279 QTVASCVFLP-RALALMPLIATSSHDCKVKIWNQDTG 314
Score = 38.9 bits (89), Expect = 0.014
Identities = 50/244 (20%), Positives = 84/244 (34%), Gaps = 59/244 (24%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H E+ V P SS + DR++ +W++ GS + Q L G +T + P Q
Sbjct: 102 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS-QPRQQLCGHAMVVTGLAVSPDSSQ 160
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD---- 450
+ + + LW V QS E S ++ VT + + S D+T++ WD
Sbjct: 161 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 220
Query: 451 -------------------------------LGRAYCSRTINVLSYCNDVVCGDH----- 474
G C T+ L + +C
Sbjct: 221 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 280
Query: 475 ---------------IIISGHNDQKIRFWDSRGPHC--TQVIPVQGRVTSLSLSHDQLHL 517
+I + +D K++ W+ C T + G +TSL++ D + L
Sbjct: 281 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVG-DAISL 339
Query: 518 LSCS 521
L S
Sbjct: 340 LCAS 343
Score = 37.4 bits (85), Expect = 0.041
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 17/201 (8%)
Query: 422 KDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHN 481
+ K+ + +K R + R +T + A+ T++V++ N +C +SG
Sbjct: 28 QSKLKHSTYKYGRPDEIIEERIQTKAFQEYSPAHMD-TVSVVAALNSDLC-----VSGGK 81
Query: 482 DQKIRFWDSR-GPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNI-RQV 539
D+ + ++ + G + + +T ++ S SRD + + DL S+ RQ
Sbjct: 82 DKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQ 141
Query: 540 FRADGFKCGSDW--TKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAV 597
CG T SPD S GS D L +WDV TG+ R V +
Sbjct: 142 L------CGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR-NVVTHL 194
Query: 598 AWCYSGSHMVSVDQGRKVVLW 618
W +++ + + + LW
Sbjct: 195 CWVPREPYILQTSEDKTLRLW 215
>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
Length = 366
Score = 73.2 bits (178), Expect = 7e-13
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 23/277 (8%)
Query: 320 VAARLPTRA-QDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEG 378
+ R+ T+A Q+ AH+ V+ V NS L +GG D+ + +N + + +G
Sbjct: 44 IEERIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVV--KRFKG 100
Query: 379 AGGSITSVDFDPSGYQVLAATYNQAAQLWKV-GEAQSKETLSGHKDKVTAAKFKLTRHQA 437
IT V P Q +A+ ++ +W + G +Q ++ L GH VT Q
Sbjct: 101 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQL 160
Query: 438 VTGSRDRTVKEWD------LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR 491
TGSRD T+ WD + RA SR + V C V + I+ D+ +R WDSR
Sbjct: 161 CTGSRDNTLLLWDVVTGQSVERASVSRNV-VTHLC--WVPREPYILQTSEDKTLRLWDSR 217
Query: 492 GPHCTQVIPVQGRV-TSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
G + P + + T +S D +SCS + + + ++RQ G
Sbjct: 218 GLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHF 277
Query: 551 WTKA--VFSPDRSYAL-----AGSCDGALYIWDVDTG 580
T A VF P R+ AL S D + IW+ DTG
Sbjct: 278 QTVASCVFLP-RALALMPLIATSSHDCKVKIWNQDTG 313
Score = 38.9 bits (89), Expect = 0.014
Identities = 50/244 (20%), Positives = 84/244 (34%), Gaps = 59/244 (24%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H E+ V P SS + DR++ +W++ GS + Q L G +T + P Q
Sbjct: 101 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS-QPRQQLCGHAMVVTGLAVSPDSSQ 159
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD---- 450
+ + + LW V QS E S ++ VT + + S D+T++ WD
Sbjct: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 219
Query: 451 -------------------------------LGRAYCSRTINVLSYCNDVVCGDH----- 474
G C T+ L + +C
Sbjct: 220 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 279
Query: 475 ---------------IIISGHNDQKIRFWDSRGPHC--TQVIPVQGRVTSLSLSHDQLHL 517
+I + +D K++ W+ C T + G +TSL++ D + L
Sbjct: 280 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVG-DAISL 338
Query: 518 LSCS 521
L S
Sbjct: 339 LCAS 342
Score = 36.2 bits (82), Expect = 0.092
Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 16/164 (9%)
Query: 459 TINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR-GPHCTQVIPVQGRVTSLSLSHDQLHL 517
T++V++ N +C +SG D+ + ++ + G + + +T ++
Sbjct: 63 TVSVVAALNSDLC-----VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQF 117
Query: 518 LSCSRDNTLKVIDLRVSNI-RQVFRADGFKCGSDW--TKAVFSPDRSYALAGSCDGALYI 574
S SRD + + DL S+ RQ CG T SPD S GS D L +
Sbjct: 118 FSASRDRMVMMWDLHGSSQPRQQL------CGHAMVVTGLAVSPDSSQLCTGSRDNTLLL 171
Query: 575 WDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
WDV TG+ R V + W +++ + + + LW
Sbjct: 172 WDVVTGQSVERASVSR-NVVTHLCWVPREPYILQTSEDKTLRLW 214
>gi|31543297 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 1 [Homo sapiens]
Length = 917
Score = 72.8 bits (177), Expect = 9e-13
Identities = 68/298 (22%), Positives = 124/298 (41%), Gaps = 25/298 (8%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H V + N S + T D + +++ L+ +++ + +++S P
Sbjct: 629 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQ--RSISFSNMALSSCLLLPGDAT 686
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
V+ ++++ + + + ++TL GH D V+ K ++ + S D TVK W A
Sbjct: 687 VITSSWDNNVYFYSIAFGRRQDTLMGHDDAVS--KICWHDNRLYSASWDSTVKVWSGVPA 744
Query: 455 YCSRT----INVLSYCNDVVCGDHI--------IISGHNDQKIRFWDSRGPHCTQVIPVQ 502
T ++L+ V D I ++SG + + WD IP
Sbjct: 745 EMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCH 804
Query: 503 -GRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRS 561
G V + S D H+LS D L VID++ + SD + F D +
Sbjct: 805 SGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMT-------SDEPQRCFVWDGN 857
Query: 562 YALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
L+GS G L +WD+ K+ R+QG H AV + S +++ + R+++ W+
Sbjct: 858 SVLSGSQSGELLVWDLLGAKISERIQG-HTGAVTCIWMNEQCSSIITGGEDRQIIFWK 914
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 5/120 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
+ H V F P+S + + G D +++ +V L ++ T + F
Sbjct: 801 IPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRC-----FVWD 855
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G VL+ + + +W + A+ E + GH VT +TG DR + W L
Sbjct: 856 GNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKL 915
>gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
Length = 948
Score = 72.8 bits (177), Expect = 9e-13
Identities = 68/298 (22%), Positives = 124/298 (41%), Gaps = 25/298 (8%)
Query: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
H V + N S + T D + +++ L+ +++ + +++S P
Sbjct: 660 HKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQ--RSISFSNMALSSCLLLPGDAT 717
Query: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
V+ ++++ + + + ++TL GH D V+ K ++ + S D TVK W A
Sbjct: 718 VITSSWDNNVYFYSIAFGRRQDTLMGHDDAVS--KICWHDNRLYSASWDSTVKVWSGVPA 775
Query: 455 YCSRT----INVLSYCNDVVCGDHI--------IISGHNDQKIRFWDSRGPHCTQVIPVQ 502
T ++L+ V D I ++SG + + WD IP
Sbjct: 776 EMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCH 835
Query: 503 -GRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRS 561
G V + S D H+LS D L VID++ + SD + F D +
Sbjct: 836 SGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMT-------SDEPQRCFVWDGN 888
Query: 562 YALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
L+GS G L +WD+ K+ R+QG H AV + S +++ + R+++ W+
Sbjct: 889 SVLSGSQSGELLVWDLLGAKISERIQG-HTGAVTCIWMNEQCSSIITGGEDRQIIFWK 945
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 5/120 (4%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
+ H V F P+S + + G D +++ +V L ++ T + F
Sbjct: 832 IPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRC-----FVWD 886
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G VL+ + + +W + A+ E + GH VT +TG DR + W L
Sbjct: 887 GNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKL 946
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/276 (23%), Positives = 110/276 (39%), Gaps = 17/276 (6%)
Query: 323 RLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGS 382
R+ R + L HL+++ A+ +G +S LL + D + +W+ + L +
Sbjct: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW-- 99
Query: 383 ITSVDFDPSGYQVLAATYNQAAQLWKV----GEAQSKETLSGHKDKVTAAKFKLTRHQAV 438
+ + + PSG V + ++ + G + L GH ++ +F L +Q +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQII 158
Query: 439 TGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVC-----GDHIIISGHNDQKIRFWDSRGP 493
T S D T WD+ +T+ + DV+ +SG D I+ WD R
Sbjct: 159 TSSGDTTCALWDIETG--QQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 494 HCTQV-IPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWT 552
C Q I + + +++ + + S D T ++ DLR ++ D CG T
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGI--T 274
Query: 553 KAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQG 588
FS LAG D IWD G L G
Sbjct: 275 SVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAG 310
Score = 66.2 bits (160), Expect = 8e-11
Identities = 54/229 (23%), Positives = 104/229 (45%), Gaps = 28/229 (12%)
Query: 318 VCVAARLPTRAQDV-----LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEA 372
+C L TR +V L H ++ RF ++ ++ + G D LW++ +
Sbjct: 120 ICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIETGQ--- 175
Query: 373 NQTLEGAG--GSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKF 430
QT+ AG G + S+ P G ++ + + +LW V ++ ++T GH+ + A F
Sbjct: 176 -QTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAF 234
Query: 431 KLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCND-VVCG---------DHIIISGH 480
+ TGS D T + +DL +L Y +D ++CG ++++G+
Sbjct: 235 FPNGYAFTTGSDDATCRLFDL-----RADQELLMYSHDNIICGITSVAFSRSGRLLLAGY 289
Query: 481 NDQKIRFWDS-RGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKV 528
+D WD+ +G + RV+ L ++ D + + + S D+ LK+
Sbjct: 290 DDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/155 (26%), Positives = 65/155 (41%), Gaps = 11/155 (7%)
Query: 304 SIGGAPEQRYQIIPVCVAARLPTRAQDVLDA--------HLSEVNAVRFGPNSSLLATGG 355
S+ AP+ R + C A+ + DV D+ H S++NAV F PN TG
Sbjct: 189 SLSLAPDGRTFVSGACDAS---IKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 356 ADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSK 415
D L+++ + + + ITSV F SG +LA + +W +
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 416 ETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
L+GH ++V+ TGS D +K W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 70.9 bits (172), Expect = 3e-12
Identities = 63/267 (23%), Positives = 117/267 (43%), Gaps = 21/267 (7%)
Query: 320 VAARLPTRAQDVLDAHLSEVNAVRFGPNSS-LLATGGADRLIHLWNVVGSRLEANQTLEG 378
V + + Q+++ AH S V+++ G S LLATGG D ++LW++ ++ +L G
Sbjct: 5 VVTKTAWKLQEIV-AHASNVSSLVLGKASGRLLATGGDDCRVNLWSI--NKPNCIMSLTG 61
Query: 379 AGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAV 438
+ SV + ++A + + + ++W + A+ TL GHK + + F
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 439 TGSRDRTVKEWDLGRAYC-------SRTINVLSYCNDVVCGDHIIISGHNDQKIRFWD-S 490
+GS+D +K WD+ R C S+ + L + D + S +D ++ WD +
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD----GKWLASAADDHTVKLWDLT 177
Query: 491 RGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
G ++ G V + ++ L S S D T++ DL + + S
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRS- 236
Query: 551 WTKAVFSPDRSYALAGSCDG-ALYIWD 576
+F+PD +G D +Y W+
Sbjct: 237 ---VLFNPDGCCLYSGCQDSLRVYGWE 260
Score = 60.5 bits (145), Expect = 5e-09
Identities = 48/189 (25%), Positives = 79/189 (41%), Gaps = 12/189 (6%)
Query: 406 LWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTI--NVL 463
LW + + +L+GH V + + V GS+ +++ WDL A RT+ +
Sbjct: 47 LWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 106
Query: 464 SYCN-DVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGR---VTSLSLSHDQLHLLS 519
+ C+ D + SG D I+ WD R C V +G V L S D L S
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC--VFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 520 CSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDT 579
+ D+T+K+ DL + F F P+ +GS D + WD++
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHT----GPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Query: 580 GKLESRLQG 588
++ S ++G
Sbjct: 221 FQVVSCIEG 229
Score = 60.5 bits (145), Expect = 5e-09
Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 17/220 (7%)
Query: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
L H + + ++ F P +A+G D I LW++ R G ++ + F P
Sbjct: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI--RRKGCVFRYRGHSQAVRCLRFSPD 158
Query: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL 451
G + +A + +LW + + GH V +F + +GS DRT++ WDL
Sbjct: 159 GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Query: 452 GR---AYCSR----TINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQ-G 503
+ C + + + D C + SG D +R + C V+ V G
Sbjct: 219 EKFQVVSCIEGEPGPVRSVLFNPDGCC----LYSGCQD-SLRVYGWEPERCFDVVLVNWG 273
Query: 504 RVTSLSLSHDQLHLLSCSRDNTLK-VIDL-RVSNIRQVFR 541
+V L++ +DQL ++ S+ N V+DL RV+ V R
Sbjct: 274 KVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVAR 313
Score = 47.0 bits (110), Expect = 5e-05
Identities = 49/217 (22%), Positives = 85/217 (39%), Gaps = 16/217 (7%)
Query: 407 WKVGEAQSKETLSGHKDKVTAAKF-KLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSY 465
WK+ E + H V++ K + TG D V W + + C ++ +
Sbjct: 11 WKLQE------IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTS 64
Query: 466 CNDVV---CGDHIIISGHNDQKIRFWDSRGPHCTQVIPV-QGRVTSLSLSHDQLHLLSCS 521
+ V + +I++G IR WD + + + + SL + S S
Sbjct: 65 PVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGS 124
Query: 522 RDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGK 581
+D +K+ D+R VFR G + FSPD + + + D + +WD+ GK
Sbjct: 125 QDTNIKLWDIRRKGC--VFRYRGHSQAVRCLR--FSPDGKWLASAADDHTVKLWDLTAGK 180
Query: 582 LESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
+ S G H VN V + + + S R + W
Sbjct: 181 MMSEFPG-HTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,468,313
Number of Sequences: 37866
Number of extensions: 1037609
Number of successful extensions: 8244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 242
Number of HSP's successfully gapped in prelim test: 530
Number of HSP's that attempted gapping in prelim test: 4799
Number of HSP's gapped (non-prelim): 2539
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.