Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 13376840

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13376840 WD repeat domain 61 [Homo sapiens]
         (305 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13376840 WD repeat domain 61 [Homo sapiens]                        629   0.0  
gi|32189425 WD repeat domain 69 [Homo sapiens]                        129   4e-30
gi|113865883 WD repeat domain 38 [Homo sapiens]                       122   5e-28
gi|16554629 WD repeat domain 5 [Homo sapiens]                         118   6e-27
gi|16554627 WD repeat domain 5 [Homo sapiens]                         118   6e-27
gi|23199987 WD repeat domain 5B [Homo sapiens]                        108   5e-24
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   107   1e-23
gi|26665869 WD repeat domain 51B [Homo sapiens]                       105   7e-23
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            104   9e-23
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            104   9e-23
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]              104   1e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    103   2e-22
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    102   3e-22
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...   102   3e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    102   6e-22
gi|19913369 transducin beta-like 3 [Homo sapiens]                     101   7e-22
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   101   9e-22
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...   100   2e-21
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...   100   2e-21
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           100   3e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    99   5e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    99   5e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    99   5e-21
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             98   8e-21
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    98   1e-20
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    94   2e-19
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    93   3e-19
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    93   3e-19
gi|189571685 WD repeat, sterile alpha motif and U-box domain con...    93   3e-19
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...    93   3e-19

>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score =  629 bits (1622), Expect = 0.0
 Identities = 305/305 (100%), Positives = 305/305 (100%)

Query: 1   MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL 60
           MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL
Sbjct: 1   MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL 60

Query: 61  EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120
           EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY
Sbjct: 61  EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120

Query: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
           LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG
Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180

Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
           KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF
Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240

Query: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
           CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI
Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300

Query: 301 YDCPI 305
           YDCPI
Sbjct: 301 YDCPI 305


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  129 bits (323), Expect = 4e-30
 Identities = 68/289 (23%), Positives = 137/289 (47%), Gaps = 5/289 (1%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
           + H + ++++A+        + + TGS D   K+W     +     +  GH   +V +  
Sbjct: 131 EGHRNVVYAIAFNN---PYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSF 185

Query: 73  SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
           +    + A+ S+D   +LWD++NG+++ ++     +  +L+F+     + TG+    V +
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245

Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
           +  ++G+K   L      I S +++ D   + +G++D    ++D   GK + TL GH   
Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305

Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
           I    F    +L+ TAS DG  +I+          L GH   +  ++F P   H ++ SS
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365

Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           DK+ ++WD  T  C+     H D+++   +N  G+ +++   D    I+
Sbjct: 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  124 bits (312), Expect = 8e-29
 Identities = 77/303 (25%), Positives = 152/303 (50%), Gaps = 9/303 (2%)

Query: 2   TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRD-ERLDLQWSL 60
           +N    LFK  +AH   + +VA      ++    +TGS D   K+W     E L+   +L
Sbjct: 78  SNHTFYLFKVLKAHILPLTNVALN----KSGSCFITGSYDRTCKLWDTASGEELN---TL 130

Query: 61  EGHQLGVVSVDISHTL-PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ 119
           EGH+  V ++  ++      A+ S D   +LW +E GK   +      +   L+F+P S 
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190

Query: 120 YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT 179
            +ATG+      ++ +++G++ Y+L      I+S++++  G  + +G+ D  + ++D  T
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250

Query: 180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVA 239
           G+ ++ L GH   I S +F+ D  L++T S D   K++D  +     TL+GH   +L+  
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
           F        ++S+D + +++   TR C+     H+ ++  + +N  G+ +++   D+   
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370

Query: 300 IYD 302
           I+D
Sbjct: 371 IWD 373


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  122 bits (305), Expect = 5e-28
 Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 6/269 (2%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
           + + ++TGS D  V  W+ R  +L   W L GH   V     S    + AS+S D  +RL
Sbjct: 32  DGQMLLTGSEDGCVYGWETRSGQL--LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89

Query: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
           WD+   K ++ +        T++FSPDS+ LA+G    +V ++ V+SG+    L      
Sbjct: 90  WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDI--ATGKLLH-TLEGHAMPIRSLTFSPDSQLLVT 207
           I S  +SP    LA+G+ D  ++I+D+   T  + H  LEGH+  I  L +S  S LL +
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLAS 208

Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
            S D  I I+    ++L   L GH +WV ++AF PD+    S+   + VKVWD  T  C+
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL 268

Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQ 296
            T     D      +  +G  +VS   DQ
Sbjct: 269 ETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 11/176 (6%)

Query: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
           V +V  FG   G+           + S A+SPDG+ L +G+ DG +  ++  +G+LL  L
Sbjct: 11  VRRVKFFGQHGGE-----------VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59

Query: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
            GH  P++   FSPD  L  +AS D  ++++DV  A     L GH   V  V+F PD   
Sbjct: 60  GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ 119

Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
             S   DK V +WDV +   +     H+D +    ++   + + +   D  +HI+D
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 58/192 (30%), Positives = 94/192 (48%), Gaps = 4/192 (2%)

Query: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
           AFSPD Q L TG+  G V  +   SG+  + L      +    +SPDG   AS + D  +
Sbjct: 28  AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87

Query: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
            ++D+A  K L  L+GH   + +++FSPDS+ L +   D  + ++DVQ   +   L GH 
Sbjct: 88  RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147

Query: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVG--TRTCVHTFFD-HQDQVWGVKYNGNGSKI 289
             + +  F P      + S D +V +WD+   T    H   + H   +  + Y+ +G  +
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LL 206

Query: 290 VSVGDDQEIHIY 301
            S   D+ IHI+
Sbjct: 207 ASGSWDKTIHIW 218



 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 54/226 (23%), Positives = 104/226 (46%), Gaps = 4/226 (1%)

Query: 81  SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
           + S D  +  W+  +G+ +  +           FSPD    A+ +    V ++ V   K 
Sbjct: 38  TGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKC 97

Query: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
              L    + + ++++SPD + LASG  D  + ++D+ +G++L  L GH   I+S  FSP
Sbjct: 98  LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP 157

Query: 201 DSQLLVTASDDGYIKIYDVQHANLAGT---LSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
               L T S D  + I+D++    A +   L GH++ +  + +        S S DK++ 
Sbjct: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIH 216

Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303
           +W   T + +     H   V  + ++ +   + S G  + + ++DC
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDC 262


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  118 bits (296), Expect = 6e-27
 Identities = 72/251 (28%), Positives = 130/251 (51%), Gaps = 4/251 (1%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
           L+++L GH   V SV  S      ASSS D  I++W   +GK  K+I    +    +A+S
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
            DS  L + +    + I+ V SGK   +L     ++    ++P    + SG+ D  + I+
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           D+ TGK L TL  H+ P+ ++ F+ D  L+V++S DG  +I+D        TL    +  
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216

Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
           ++ V F P+  + ++++ D ++K+WD     C+ T+  H+++ + +  N     G  IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 292 VGDDQEIHIYD 302
             +D  ++I++
Sbjct: 277 GSEDNLVYIWN 287



 Score =  110 bits (276), Expect = 1e-24
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 18/271 (6%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H  A+ SV +  N     E + + S D L+K+W   D + +   ++ GH+LG+  V  S 
Sbjct: 44  HTKAVSSVKFSPN----GEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
              +  S+S D  +++WD+ +GK +K++       +   F+P S  + +G+    V I+ 
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
           V++GK   +L      + ++ ++ DG  + S + DG+  I+D A+G+ L TL +    P+
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
             + FSP+ + ++ A+ D  +K++D        T +GH     N  +C            
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYCIFANFSVTGGKW 273

Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
            VS S D  V +W++ T+  V     H D V
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 51/199 (25%), Positives = 99/199 (49%), Gaps = 12/199 (6%)

Query: 27  NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDA 86
           N    S  +V+GS D+ V++W  +  +     +L  H   V +V  +    +  SSS D 
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 87  HIRLWDLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KE 141
             R+WD  +G+ +K++   D  PV    + FSP+ +Y+   T    + ++    GK  K 
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251

Query: 142 YSLDTRGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
           Y+     K+ +   +S   GK++ SG+ D ++ I+++ T +++  L+GH   + S    P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311

Query: 201 DSQLLVTAS--DDGYIKIY 217
              ++ +A+  +D  IK++
Sbjct: 312 TENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  118 bits (296), Expect = 6e-27
 Identities = 72/251 (28%), Positives = 130/251 (51%), Gaps = 4/251 (1%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
           L+++L GH   V SV  S      ASSS D  I++W   +GK  K+I    +    +A+S
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
            DS  L + +    + I+ V SGK   +L     ++    ++P    + SG+ D  + I+
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           D+ TGK L TL  H+ P+ ++ F+ D  L+V++S DG  +I+D        TL    +  
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216

Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
           ++ V F P+  + ++++ D ++K+WD     C+ T+  H+++ + +  N     G  IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 292 VGDDQEIHIYD 302
             +D  ++I++
Sbjct: 277 GSEDNLVYIWN 287



 Score =  110 bits (276), Expect = 1e-24
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 18/271 (6%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H  A+ SV +  N     E + + S D L+K+W   D + +   ++ GH+LG+  V  S 
Sbjct: 44  HTKAVSSVKFSPN----GEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
              +  S+S D  +++WD+ +GK +K++       +   F+P S  + +G+    V I+ 
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
           V++GK   +L      + ++ ++ DG  + S + DG+  I+D A+G+ L TL +    P+
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217

Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
             + FSP+ + ++ A+ D  +K++D        T +GH     N  +C            
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYCIFANFSVTGGKW 273

Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
            VS S D  V +W++ T+  V     H D V
Sbjct: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 51/199 (25%), Positives = 99/199 (49%), Gaps = 12/199 (6%)

Query: 27  NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDA 86
           N    S  +V+GS D+ V++W  +  +     +L  H   V +V  +    +  SSS D 
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 87  HIRLWDLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KE 141
             R+WD  +G+ +K++   D  PV    + FSP+ +Y+   T    + ++    GK  K 
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251

Query: 142 YSLDTRGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
           Y+     K+ +   +S   GK++ SG+ D ++ I+++ T +++  L+GH   + S    P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311

Query: 201 DSQLLVTAS--DDGYIKIY 217
              ++ +A+  +D  IK++
Sbjct: 312 TENIIASAALENDKTIKLW 330


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  108 bits (271), Expect = 5e-24
 Identities = 59/152 (38%), Positives = 88/152 (57%)

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           + S+ +SP+G++LAS + D +I I+    GK   TL GH + I  + +S DS  LV+ASD
Sbjct: 44  VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
           D  +K++DV+      TL GH+++V    F P     +S S D++VK+W+V T  C+ T 
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163

Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
             H D V  V +N +GS IVS   D    I+D
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195



 Score =  108 bits (270), Expect = 6e-24
 Identities = 68/251 (27%), Positives = 127/251 (50%), Gaps = 4/251 (1%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
           L+ +L GH   V SV  S      ASSS D  I +W   +GK  K++    ++   +A+S
Sbjct: 33  LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92

Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
            DS  L + +    + ++ V SGK   +L     ++    ++P    + SG+ D  + I+
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           ++ TGK L TL  H+ P+ ++ F+    L+V+ S DG  +I+D        TL    +  
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP 212

Query: 236 LN-VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291
           ++ V F P+  + ++++ D ++K+WD     C+ T+  H+++ + +  N     G  IVS
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272

Query: 292 VGDDQEIHIYD 302
             +D  ++I++
Sbjct: 273 GSEDNLVYIWN 283



 Score =  104 bits (260), Expect = 9e-23
 Identities = 73/271 (26%), Positives = 129/271 (47%), Gaps = 18/271 (6%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H +A+ SV +  N     E + + S D L+ +W   D + +   +L GH L +  V  S 
Sbjct: 40  HTEAVSSVKFSPN----GEWLASSSADRLIIIWGAYDGKYEK--TLYGHNLEISDVAWSS 93

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
                 S+S D  ++LWD+ +GK +K++       +   F+P S  + +G+    V I+ 
Sbjct: 94  DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193
           V++GK   +L      + ++ ++  G  + SG+ DG+  I+D A+G+ L TL +    P+
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213

Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-------PDDTH 246
             + FSP+ + ++TA+ D  +K++D        T +GH     N  +C            
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK----NEKYCIFANFSVTGGKW 269

Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
            VS S D  V +W++ T+  V     H D V
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300



 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 68/238 (28%), Positives = 115/238 (48%), Gaps = 13/238 (5%)

Query: 78  IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW------------TLAFSPDSQYLATGT 125
           +A   S DA  +L    +  Q K +   P  A             ++ FSP+ ++LA+ +
Sbjct: 1   MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSS 60

Query: 126 HVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185
               + I+G   GK E +L      I  +A+S D   L S + D  + ++D+ +GK L T
Sbjct: 61  ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120

Query: 186 LEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
           L+GH+  +    F+P S L+++ S D  +KI++V+      TLS H+  V  V F    +
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180

Query: 246 HFVSSSSDKSVKVWDVGTRTCVHTFFDHQD-QVWGVKYNGNGSKIVSVGDDQEIHIYD 302
             VS S D   ++WD  +  C+ T  D  +  V  VK++ NG  I++   D  + ++D
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 62/251 (24%), Positives = 124/251 (49%), Gaps = 12/251 (4%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H+  I  VAW ++    S  +V+ S D  +K+W  R  +     +L+GH   V   + + 
Sbjct: 82  HNLEISDVAWSSD----SSRLVSASDDKTLKLWDVRSGKC--LKTLKGHSNYVFCCNFNP 135

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
              +  S S D  +++W+++ GK +K++ A       + F+     + +G++ G   I+ 
Sbjct: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195

Query: 135 VESGKKEYSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
             SG+   +L D     +  + +SP+GKY+ +  +D  + ++D + G+ L T  GH    
Sbjct: 196 AASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEK 255

Query: 194 RSL--TFS-PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSS 250
             +   FS    + +V+ S+D  + I+++Q   +   L GH   V++ A  P +    S+
Sbjct: 256 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315

Query: 251 S--SDKSVKVW 259
           +  +DK++K+W
Sbjct: 316 ALENDKTIKLW 326



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 51/198 (25%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 32  SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91
           S  +++GS D+ VK+W+ +  +     +L  H   V +V  + +  +  S S D   R+W
Sbjct: 137 SNLIISGSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194

Query: 92  DLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDT 146
           D  +G+ +K++   D  PV    + FSP+ +Y+ T T    + ++    G+  K Y+   
Sbjct: 195 DAASGQCLKTLVDDDNPPVSF--VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252

Query: 147 RGKFILSIAYS-PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLL 205
             K+ +   +S   GK++ SG+ D ++ I+++ T +++  L+GH   + S    P   L+
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312

Query: 206 VTAS--DDGYIKIYDVQH 221
            +A+  +D  IK++   H
Sbjct: 313 ASAALENDKTIKLWMSNH 330


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  107 bits (267), Expect = 1e-23
 Identities = 66/289 (22%), Positives = 136/289 (47%), Gaps = 22/289 (7%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           +V+ S D  +KVW +  E  D + +L+GH   V  +   H+  + AS S D  I+LWD +
Sbjct: 123 MVSASEDATIKVWDY--ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
             + I+++     +  ++A  P+  ++ + +    + ++ V++G    +     +++  +
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240

Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQ----------- 203
             + DG  +AS + D  + ++ +AT +    L  H   +  ++++P+S            
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300

Query: 204 ---------LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
                     L++ S D  IK++DV       TL GH +WV  V F       +S + DK
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360

Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303
           +++VWD   + C+ T   H+  V  + ++     +V+   DQ + +++C
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409



 Score =  100 bits (250), Expect = 1e-21
 Identities = 52/162 (32%), Positives = 88/162 (54%)

Query: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS 199
           ++Y+L      +  + + P    + S + D  I ++D  TG    TL+GH   ++ ++F 
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159

Query: 200 PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
              +LL + S D  IK++D Q      T+ GH   V +VA  P+  H VS+S DK++K+W
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219

Query: 260 DVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           +V T  CV TF  H++ V  V+ N +G+ I S  +DQ + ++
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261



 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 60/266 (22%), Positives = 123/266 (46%), Gaps = 20/266 (7%)

Query: 57  QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP 116
           +++L GH+  V  V       +  S+S DA I++WD E G   +++         ++F  
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160

Query: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
             + LA+ +    + ++  +  +   ++      + S+A  P+G ++ S + D  I +++
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220

Query: 177 IATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVL 236
           + TG  + T  GH   +R +  + D  L+ + S+D  ++++ V        L  H   V 
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280

Query: 237 NVAFCPDDTH--------------------FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQ 276
            +++ P+ ++                     +S S DK++K+WDV T  C+ T   H + 
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340

Query: 277 VWGVKYNGNGSKIVSVGDDQEIHIYD 302
           V GV ++  G  I+S  DD+ + ++D
Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWD 366


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  105 bits (261), Expect = 7e-23
 Identities = 58/192 (30%), Positives = 93/192 (48%)

Query: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
           +L  SP+ + LAT +    + ++  +   + Y        + S+ +SP G  LAS + D 
Sbjct: 23  SLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDR 82

Query: 171 IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
            + ++           + H  P+RS+ FS D Q L TAS+D  IK++ +       +L  
Sbjct: 83  TVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR 142

Query: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
           H  WV    F PD    VS S DK++K+WD   + CV+ F D       V +N +G+ I 
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 202

Query: 291 SVGDDQEIHIYD 302
           S G DQ + ++D
Sbjct: 203 SAGSDQTVKVWD 214



 Score =  100 bits (249), Expect = 2e-21
 Identities = 69/295 (23%), Positives = 134/295 (45%), Gaps = 6/295 (2%)

Query: 7   ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
           +L +  + H  AI S+    N K+    + T S D  + +W ++      ++   GH+  
Sbjct: 9   VLERYFKGHKAAITSLDLSPNGKQ----LATASWDTFLMLWNFKPHARAYRYV--GHKDV 62

Query: 67  VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
           V SV  S    + AS+S D  +RLW  +   +     A      ++ FS D Q+LAT + 
Sbjct: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122

Query: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
              + ++ +   +  YSL     ++    +SPDG+ + S + D  I I+D    + ++  
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182

Query: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
                    + F+P    + +A  D  +K++DV+   L      H+  V  ++F P   +
Sbjct: 183 SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNY 242

Query: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
            +++SSD ++K+ D+     ++T   H   V+ V ++  G    S G D ++ ++
Sbjct: 243 LITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score =  100 bits (248), Expect = 2e-21
 Identities = 62/247 (25%), Positives = 116/247 (46%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
           L+   +GH+  + S+D+S      A++S D  + LW+ +   +            ++ FS
Sbjct: 10  LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69

Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
           P    LA+ +    V ++  +   K          + S+ +S DG++LA+ + D  I ++
Sbjct: 70  PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
            +   + L++L  H   +R   FSPD +L+V+ S+D  IKI+D  +       S    + 
Sbjct: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189

Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDD 295
             V F P  T   S+ SD++VKVWDV     +  +  H   V  + ++ +G+ +++   D
Sbjct: 190 NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249

Query: 296 QEIHIYD 302
             + I D
Sbjct: 250 GTLKILD 256


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  104 bits (260), Expect = 9e-23
 Identities = 66/227 (29%), Positives = 107/227 (47%), Gaps = 16/227 (7%)

Query: 77  PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGV 135
           P A   SL+ H +               G  DA T   FS +++ LA+G+    + ++ +
Sbjct: 4   PCAEDPSLERHFK---------------GHRDAVTCVDFSINTKQLASGSMDSCLMVWHM 48

Query: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
           +   + Y        +  + +SP G  LASG+ D  + I+             H   +RS
Sbjct: 49  KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS 108

Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
           + F  D Q  VTASDD  +K++         +LS H +WV    F PD    VS+S DK+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT 168

Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           VK+WD  +R CVH++ +H   V  V ++ +G+ I + G D  + ++D
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215



 Score =  103 bits (256), Expect = 2e-22
 Identities = 65/289 (22%), Positives = 133/289 (46%), Gaps = 6/289 (2%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
           + H DA+  V +  N K+    + +GS+D  + VW  + +    +++  GH+  V  V+ 
Sbjct: 16  KGHRDAVTCVDFSINTKQ----LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNF 69

Query: 73  SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
           S +  + AS S D  +R+W      +     A      ++ F  D Q   T +    V +
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
           +     K  +SL     ++    +SPDG+ + S + D  + ++D ++ + +H+   H   
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189

Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
           +  + F P    +  A  D  +K++DV+   L      H++ V  ++F P   + +++SS
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           D ++K+ D+     ++T   HQ     V ++  G    S G D+++ ++
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score =  100 bits (248), Expect = 2e-21
 Identities = 66/248 (26%), Positives = 113/248 (45%), Gaps = 2/248 (0%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-F 114
           L+   +GH+  V  VD S      AS S+D+ + +W ++   +      G  DA T   F
Sbjct: 11  LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNF 69

Query: 115 SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
           SP    LA+G+    V I+      +          + S+ +  DG+   + + D  + +
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
           +     K L +L  H   +R   FSPD +L+V+ASDD  +K++D        +   H  +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189

Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294
           V  V F P  T   ++  D +VKVWDV T   +  +  H   V G+ ++ +G+ +++   
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 295 DQEIHIYD 302
           D  + I D
Sbjct: 250 DSTLKILD 257


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  104 bits (260), Expect = 9e-23
 Identities = 66/227 (29%), Positives = 107/227 (47%), Gaps = 16/227 (7%)

Query: 77  PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGV 135
           P A   SL+ H +               G  DA T   FS +++ LA+G+    + ++ +
Sbjct: 4   PCAEDPSLERHFK---------------GHRDAVTCVDFSINTKQLASGSMDSCLMVWHM 48

Query: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
           +   + Y        +  + +SP G  LASG+ D  + I+             H   +RS
Sbjct: 49  KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS 108

Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
           + F  D Q  VTASDD  +K++         +LS H +WV    F PD    VS+S DK+
Sbjct: 109 VHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT 168

Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           VK+WD  +R CVH++ +H   V  V ++ +G+ I + G D  + ++D
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215



 Score =  103 bits (256), Expect = 2e-22
 Identities = 65/289 (22%), Positives = 133/289 (46%), Gaps = 6/289 (2%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
           + H DA+  V +  N K+    + +GS+D  + VW  + +    +++  GH+  V  V+ 
Sbjct: 16  KGHRDAVTCVDFSINTKQ----LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNF 69

Query: 73  SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
           S +  + AS S D  +R+W      +     A      ++ F  D Q   T +    V +
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
           +     K  +SL     ++    +SPDG+ + S + D  + ++D ++ + +H+   H   
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189

Query: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
           +  + F P    +  A  D  +K++DV+   L      H++ V  ++F P   + +++SS
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           D ++K+ D+     ++T   HQ     V ++  G    S G D+++ ++
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score =  100 bits (248), Expect = 2e-21
 Identities = 66/248 (26%), Positives = 113/248 (45%), Gaps = 2/248 (0%)

Query: 56  LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-F 114
           L+   +GH+  V  VD S      AS S+D+ + +W ++   +      G  DA T   F
Sbjct: 11  LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNF 69

Query: 115 SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
           SP    LA+G+    V I+      +          + S+ +  DG+   + + D  + +
Sbjct: 70  SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129

Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
           +     K L +L  H   +R   FSPD +L+V+ASDD  +K++D        +   H  +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189

Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294
           V  V F P  T   ++  D +VKVWDV T   +  +  H   V G+ ++ +G+ +++   
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 295 DQEIHIYD 302
           D  + I D
Sbjct: 250 DSTLKILD 257


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score =  104 bits (259), Expect = 1e-22
 Identities = 60/226 (26%), Positives = 107/226 (47%), Gaps = 11/226 (4%)

Query: 88  IRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
           ++L+DL +G  +++IDA     W+++ SPD +   TG     V  +  E  K E S   R
Sbjct: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKR 537

Query: 148 -----------GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSL 196
                       + +L ++YSP+ K LA   +D  + IF + T K   +L GH +P+  +
Sbjct: 538 LSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICM 597

Query: 197 TFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSV 256
             S D  L+ T S D  +KI+ +   +   +L  H   V+ + F P    F ++  D  +
Sbjct: 598 DISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKI 657

Query: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           K WD      + T   H  ++W +  + +G  +VS   D+ + +++
Sbjct: 658 KQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 50/175 (28%), Positives = 87/175 (49%)

Query: 87  HIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
           H+ +WDL  G++I  +     +   L  SPD  +LA G   G + IF + SG+   + + 
Sbjct: 46  HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105

Query: 147 RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
               I ++ Y   G  LASG+ D  I ++D+     L+ L+GH   I    F  +  LLV
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165

Query: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
           T+  D  +K +D+   +   T+ GH + V  +    ++   ++ +SD  ++VWD+
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 50/173 (28%), Positives = 82/173 (47%)

Query: 130 VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
           V I+ +  G+K   L    + +  +  SPDG +LA G  DG I IF + +G+   T  GH
Sbjct: 47  VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106

Query: 190 AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVS 249
              I +L +      L + S D  I ++DV + +    L GH   +    F  +    V+
Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166

Query: 250 SSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           S  D  VK WD+ T+ C  T   H+ +VWG+       ++++   D E+ ++D
Sbjct: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 56/223 (25%), Positives = 97/223 (43%), Gaps = 15/223 (6%)

Query: 6   GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---RDERLDLQWSLEG 62
           G L +   AHD A+WS++   +++      VTG  D  VK W +   +DE    Q  L  
Sbjct: 486 GNLLETIDAHDGALWSMSLSPDQRG----FVTGGADKSVKFWDFELVKDEN-STQKRLSV 540

Query: 63  HQL-------GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
            Q         V+ V  S    + A S LD  ++++ ++  K   S+    +    +  S
Sbjct: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600

Query: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
            D   +ATG+    V I+G++ G    SL      ++ + + P      +   D  I  +
Sbjct: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
           D    + + TLEGH   I  L  SP    +V++S D  +++++
Sbjct: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 37/164 (22%), Positives = 74/164 (45%), Gaps = 11/164 (6%)

Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
           ++ L   + P  + +  G   G + ++D+A+G LL T++ H   + S++ SPD +  VT 
Sbjct: 455 EYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTG 514

Query: 209 SDDGYIKIYDVQHANLAGTLSGHASW-----------VLNVAFCPDDTHFVSSSSDKSVK 257
             D  +K +D +      +     S            VL V++ P+      S  D +VK
Sbjct: 515 GADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVK 574

Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           ++ V T     + + H+  V  +  + +G+ I +   D+ + I+
Sbjct: 575 IFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW 618



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 5/111 (4%)

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTAS 209
           + ++++S D   + S A D I  I++ +T + + T+   +A+      F P  + +V  +
Sbjct: 418 VRTLSFSSDNIAVLSAAADSI-KIWNRSTLQCIRTMTCEYAL---CSFFVPGDRQVVIGT 473

Query: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
             G +++YD+   NL  T+  H   + +++  PD   FV+  +DKSVK WD
Sbjct: 474 KTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524



 Score = 33.1 bits (74), Expect = 0.31
 Identities = 20/90 (22%), Positives = 41/90 (45%)

Query: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD 272
           ++ I+D++       L G    V  +   PD  H      D S++++ + +     TF  
Sbjct: 46  HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105

Query: 273 HQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           H+  +  +KY+  G ++ S   D +I ++D
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWD 135



 Score = 33.1 bits (74), Expect = 0.31
 Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 2/101 (1%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           + +GS D  + VW   +E     + L+GH+  +          +  +S  D  ++ WDL+
Sbjct: 122 LASGSKDTDIIVWDVINE--SGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLD 179

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV 135
                K++     + W L    + + L TG    ++ ++ +
Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 29.6 bits (65), Expect = 3.5
 Identities = 32/130 (24%), Positives = 53/130 (40%), Gaps = 20/130 (15%)

Query: 59  SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPD 117
           +  GH+  + ++         AS S D  I +WD+ N   +  +  G  DA T A F  +
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KGHKDAITQALFLRE 160

Query: 118 SQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF---------ILSIAYSPDGKYLASGAI 168
              L T          G ++  K + LDT+  F         +  +    + K L +GA 
Sbjct: 161 KNLLVTS---------GKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS 211

Query: 169 DGIINIFDIA 178
           D  + ++DIA
Sbjct: 212 DSELRVWDIA 221


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  103 bits (256), Expect = 2e-22
 Identities = 64/246 (26%), Positives = 109/246 (44%), Gaps = 6/246 (2%)

Query: 19  IWSVA---WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWS-LEGHQLGVVSVDISH 74
           +WSV      + K+ +  +++    DD+++  +  DE+   +   L GH   V     S 
Sbjct: 496 VWSVTPKKLRSVKQASDLSLIDKESDDVLE--RIMDEKTASELKILYGHSGPVYGASFSP 553

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
                 SSS D  +RLW L+    +          W   FSP   Y  +G H     ++ 
Sbjct: 554 DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWA 613

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
            +  +           +    + P+  Y+A+G+ D  + ++D+  G  +    GH  PI 
Sbjct: 614 TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH 673

Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
           SLTFSP+ + L T + DG + ++D+ H  + G L GH   V ++ F  D     S S D 
Sbjct: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733

Query: 255 SVKVWD 260
           +V++WD
Sbjct: 734 TVRLWD 739



 Score = 91.7 bits (226), Expect = 7e-19
 Identities = 62/275 (22%), Positives = 118/275 (42%), Gaps = 17/275 (6%)

Query: 30  ENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
           ++S  +  G  D  V+VW    ++L              SV  +  L +    S D   R
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLER 526

Query: 90  LWDLENGKQIKSI--DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
           + D +   ++K +   +GPV  +  +FSPD  YL + +  G V ++ +++          
Sbjct: 527 IMDEKTASELKILYGHSGPV--YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH 584

Query: 148 GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVT 207
              +    +SP G Y  SG  D +  ++     + L    GH   +    F P+S  + T
Sbjct: 585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVAT 644

Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
            S D  ++++DV + N     +GH   + ++ F P+     + ++D  V +WD+G    V
Sbjct: 645 GSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704

Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
                H D V  ++++ +G  + S   D  + ++D
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  102 bits (255), Expect = 3e-22
 Identities = 65/253 (25%), Positives = 117/253 (46%), Gaps = 6/253 (2%)

Query: 14  AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73
           AH   + S+  G   K +   + TG  D  V +W        +  SL GH   V SV ++
Sbjct: 18  AHASNVSSLVLG---KASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLN 72

Query: 74  HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133
               +  + S    IR+WDLE  K ++++     +  +L F P  +++A+G+    + ++
Sbjct: 73  TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132

Query: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
            +      +      + +  + +SPDGK+LAS A D  + ++D+  GK++    GH  P+
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192

Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD 253
             + F P+  LL + S D  I+ +D++   +   + G    V +V F PD     S   D
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252

Query: 254 KSVKVWDVGTRTC 266
            S++V+      C
Sbjct: 253 -SLRVYGWEPERC 264



 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 56/224 (25%), Positives = 104/224 (46%), Gaps = 1/224 (0%)

Query: 78  IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
           + A+   D  + LW +     I S+        ++  +   + +  G+  G + ++ +E+
Sbjct: 35  LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94

Query: 138 GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197
            K   +L      I S+ + P G+++ASG+ D  I ++DI     +    GH+  +R L 
Sbjct: 95  AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154

Query: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
           FSPD + L +A+DD  +K++D+    +     GH   V  V F P++    S SSD++++
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214

Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
            WD+     V         V  V +N +G  + S G    + +Y
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSLRVY 257



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 40/143 (27%), Positives = 77/143 (53%)

Query: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
           G+ LA+G  D  +N++ I     + +L GH  P+ S+  +   +L+V  S  G I+++D+
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92

Query: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG 279
           + A +  TL GH + + ++ F P      S S D ++K+WD+  + CV  +  H   V  
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152

Query: 280 VKYNGNGSKIVSVGDDQEIHIYD 302
           ++++ +G  + S  DD  + ++D
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWD 175



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 50/182 (27%), Positives = 86/182 (47%)

Query: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
           LATG    +VN++ +       SL      + S+  +   + + +G+  G I ++D+   
Sbjct: 36  LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95

Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
           K+L TL GH   I SL F P  + + + S D  IK++D++         GH+  V  + F
Sbjct: 96  KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155

Query: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
            PD     S++ D +VK+WD+     +  F  H   V  V+++ N   + S   D+ I  
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215

Query: 301 YD 302
           +D
Sbjct: 216 WD 217


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score =  102 bits (255), Expect = 3e-22
 Identities = 54/197 (27%), Positives = 102/197 (51%), Gaps = 5/197 (2%)

Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
           + + +  DS+ L + +  GK+ I+   +  K +++  R  ++++ AY+P G Y+A G +D
Sbjct: 59  YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLD 118

Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
            I +I+++ T     ++   L GH   +    F  D+Q+ VT+S D    ++D++     
Sbjct: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQT 177

Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
            T +GH   V++++  PD   FVS + D S K+WDV    C  TF  H+  +  + +  N
Sbjct: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN 237

Query: 286 GSKIVSVGDDQEIHIYD 302
           G+   +  DD    ++D
Sbjct: 238 GNAFATGSDDATCRLFD 254



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 58/250 (23%), Positives = 117/250 (46%), Gaps = 7/250 (2%)

Query: 59  SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
           +L GH   + ++       +  S+S D  + +WD     ++ +I        T A++P  
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109

Query: 119 QYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIF 175
            Y+A G      +I+ +++  G    S +  G    LS     D   + + + D    ++
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169

Query: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           DI TG+   T  GH   + SL+ +PD++L V+ + D   K++DV+      T +GH S +
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229

Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNGSKIVSV 292
             + F P+   F + S D + +++D+     + T + H + + G   V ++ +G  +++ 
Sbjct: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMT-YSHDNIICGITSVSFSKSGRLLLAG 288

Query: 293 GDDQEIHIYD 302
            DD   +++D
Sbjct: 289 YDDFNCNVWD 298



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 5/230 (2%)

Query: 35  VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
           V  G LD++  ++  K R+  + +   L GH   +          I  SS  D    LWD
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWD 170

Query: 93  LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
           +E G+Q  +      D  +L+ +PD++   +G       ++ V  G    +       I 
Sbjct: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN 230

Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL--EGHAMPIRSLTFSPDSQLLVTASD 210
           +I + P+G   A+G+ D    +FD+   + L T   +     I S++FS   +LL+   D
Sbjct: 231 AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
           D    ++D   A+ AG L+GH + V  +    D     + S D  +K+W+
Sbjct: 291 DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  102 bits (253), Expect = 6e-22
 Identities = 62/215 (28%), Positives = 98/215 (45%), Gaps = 7/215 (3%)

Query: 81  SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
           S S D  IR WDL +              W L  SP S Y A+G+H     ++  +   +
Sbjct: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD---R 415

Query: 141 EYSLDTRGKFILSI---AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197
            Y L      +  +    + P+  YLA+G+ D  + ++    G  +    GH  P+ SL 
Sbjct: 416 TYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLA 475

Query: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
           FSP+ + L +A +D  +K++D+    L   L GH   + ++ F PD     S+S D SV+
Sbjct: 476 FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVR 535

Query: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292
           VWD+    C         ++ GV Y G  S ++SV
Sbjct: 536 VWDIRNTYCSAPADGSSSELVGV-YTGQMSNVLSV 569



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 59/274 (21%), Positives = 113/274 (41%), Gaps = 16/274 (5%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
           +S+ +  G  +  +K+W  R ++L      E HQ+ V  + ++  +        D     
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKL----KSEPHQVDVSRIHLACDILEEEDDEDD----- 329

Query: 91  WDLENGKQIKSI--DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG 148
                G ++K +    GPV  ++  F  DS  L + +    +  + + S           
Sbjct: 330 ---NAGTEMKILRGHCGPV--YSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384

Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
             +  +  SP   Y ASG+ D    ++       L    GH   +  + F P+S  L T 
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444

Query: 209 SDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVH 268
           S D  ++++  Q  N     +GH   VL++AF P+  +  S+  D+ +K+WD+ + T   
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504

Query: 269 TFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
               H D +  + ++ +   I S   D  + ++D
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 56/253 (22%), Positives = 97/253 (38%), Gaps = 47/253 (18%)

Query: 97  KQIKSIDAGPVDAWTLAF---------------SPDSQYLATGTHVGKVNIFGVESGK-- 139
           + IK +  GP    T+ F               SPDS+ LA G     + ++ + S K  
Sbjct: 244 ESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLK 303

Query: 140 -----------------------KEYSLDTRGKF-------ILSIAYSPDGKYLASGAID 169
                                  ++ +  T  K        + S  +  D   L S + D
Sbjct: 304 SEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSED 363

Query: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229
             I  +D+ +       +GHA P+  L  SP S    + S D   +++           +
Sbjct: 364 MSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYA 423

Query: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKI 289
           GH + V  V F P+  +  + S+DK+V++W       V  F  H+  V  + ++ NG  +
Sbjct: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL 483

Query: 290 VSVGDDQEIHIYD 302
            S G+DQ + ++D
Sbjct: 484 ASAGEDQRLKLWD 496



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 48/195 (24%), Positives = 83/195 (42%), Gaps = 13/195 (6%)

Query: 24  WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSS 83
           W  +    S    +GS D   ++W + D    L+    GH   V  V         A+ S
Sbjct: 388 WDLDISPYSLYFASGSHDRTARLWSF-DRTYPLR-IYAGHLADVDCVKFHPNSNYLATGS 445

Query: 84  LDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYS 143
            D  +RLW  + G  ++          +LAFSP+ +YLA+     ++ ++ + SG     
Sbjct: 446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKE 505

Query: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDI-----------ATGKLLHTLEGHAMP 192
           L      I S+ +SPD   +AS ++D  + ++DI           ++ +L+    G    
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565

Query: 193 IRSLTFSPDSQLLVT 207
           + S+ F   + LLVT
Sbjct: 566 VLSVQFMACNLLLVT 580


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score =  101 bits (252), Expect = 7e-22
 Identities = 73/265 (27%), Positives = 123/265 (46%), Gaps = 22/265 (8%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           VV  S    +KV++ +     +   L GH   V+++D+     + AS + D  +R+W + 
Sbjct: 350 VVVASNSPCLKVFELQTSACQI---LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQ----YLATGTHVGKVNIFGVESG------------ 138
              Q+  +  G     ++     S+    +L TG+    V ++ +               
Sbjct: 407 KAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGP 466

Query: 139 ---KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
              + + +     K I S+A +P+ K LA+G+ D    ++ +   +LL    GH   +  
Sbjct: 467 ILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWC 526

Query: 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
           + FSP  Q+L TAS DG IK++ +Q  +   T  GH + VL VAF    T  +SS SD  
Sbjct: 527 VQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586

Query: 256 VKVWDVGTRTCVHTFFDHQDQVWGV 280
           VK+W +    CV T   H+D+VWG+
Sbjct: 587 VKLWTIKNNECVRTLDAHEDKVWGL 611



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 9/189 (4%)

Query: 123 TGTHV-----GKVNIFGVESGKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIFD 176
           TG H+      +VNI  V SG    SL+   +  I +   SPD + L + +   ++  + 
Sbjct: 35  TGQHLFCVCGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWA 94

Query: 177 IATGKLLHTLEG-HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
              G +    +  H  P+ ++ F P S LL T   DG ++++D+          G    V
Sbjct: 95  WQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVV 154

Query: 236 LNVAFCPDDTHFV--SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG 293
             VAF PD T  +  SS++D +++VW +  R+C+     H   V  + ++ +G  ++S G
Sbjct: 155 HLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSG 214

Query: 294 DDQEIHIYD 302
            D+   I+D
Sbjct: 215 RDKICIIWD 223



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 66/291 (22%), Positives = 124/291 (42%), Gaps = 29/291 (9%)

Query: 32  SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL----GVVSVDISHTLP---IAASSSL 84
           S  + TG  D  V+VW       D+      H      GVV +   H  P   +  SS+ 
Sbjct: 121 STLLATGGCDGAVRVW-------DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173

Query: 85  DAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK---- 140
           DA IR+W L++   +  + A      +LAFS D   + +        I+ ++S +     
Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTV 233

Query: 141 ------EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL---EGHAM 191
                 E ++    + +  +     G Y  +    G + +++ A+G+ ++T     G   
Sbjct: 234 PVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQ 293

Query: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC-PDDTHFVSS 250
            +   T +  + +++TA+ D  + +Y+ +   L    +G++  VL+V F  P+D+H V +
Sbjct: 294 ELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA 353

Query: 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           S+   +KV+++ T  C      H D V  +     G    S   DQ + I+
Sbjct: 354 SNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 35/245 (14%)

Query: 41  DDLVKVWKWRDERLDL---QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGK 97
           D  V++W+       +   Q S   H +G V            + S D  ++LW L    
Sbjct: 397 DQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKE-SFLVTGSQDCTVKLWPLPKAL 455

Query: 98  QIKSI--DAGPV-------------DAWTLAFSPDSQYLATGTH--------VGKVNIFG 134
             K+   D GP+             D  ++A +P+ + LATG+         + +  + G
Sbjct: 456 LSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLG 515

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
           V SG +      RG  +  + +SP  + LA+ + DG I ++ +     L T EGH   + 
Sbjct: 516 VFSGHR------RG--LWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVL 567

Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
            + F      L+++  DG +K++ +++     TL  H   V  +     D H ++ +SD 
Sbjct: 568 KVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDS 627

Query: 255 SVKVW 259
            V +W
Sbjct: 628 RVILW 632



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 12/182 (6%)

Query: 88  IRLWDLENGKQIKSIDA-GPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
           + + ++ +G  ++S++     D      SPD++ L T +      +   +   +E S+  
Sbjct: 47  VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRA----LLLAQWAWQEGSVTR 102

Query: 147 RGKFI-----LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201
             K I      ++A+ P    LA+G  DG + ++DI      H   G    +  + F PD
Sbjct: 103 LWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPD 162

Query: 202 SQ--LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
               LL +++ D  I+++ +Q  +    L+ H S V ++AF  D    +SS  DK   +W
Sbjct: 163 PTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIW 222

Query: 260 DV 261
           D+
Sbjct: 223 DL 224



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 52/205 (25%), Positives = 82/205 (40%), Gaps = 14/205 (6%)

Query: 35  VVTGSLDDLVKVWKWRDE-------------RLDLQWSLEGHQLGVVSVDISHTLPIAAS 81
           +VTGS D  VK+W                   L  Q +   H   + SV I+    + A+
Sbjct: 437 LVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLAT 496

Query: 82  SSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE 141
            S D   +LW L   + +          W + FSP  Q LAT +  G + ++ ++     
Sbjct: 497 GSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556

Query: 142 YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP- 200
            + +     +L +A+   G  L S   DG++ ++ I   + + TL+ H   +  L  S  
Sbjct: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL 616

Query: 201 DSQLLVTASDDGYIKIYDVQHANLA 225
           D   L  ASD   I   DV  A  A
Sbjct: 617 DDHALTGASDSRVILWKDVTEAEQA 641



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 8/169 (4%)

Query: 12  EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71
           ++ HD  I SVA   N K     + TGS D   K+W     +  L     GH+ G+  V 
Sbjct: 475 QRCHDKDINSVAIAPNDK----LLATGSQDRTAKLWAL--PQCQLLGVFSGHRRGLWCVQ 528

Query: 72  ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAF-SPDSQYLATGTHVGKV 130
            S    + A++S D  I+LW L++   +K+ +        +AF S  +Q L++G+  G V
Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSD-GLV 587

Query: 131 NIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT 179
            ++ +++ +   +LD     +  +  S    +  +GA D  + ++   T
Sbjct: 588 KLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVT 636


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  101 bits (251), Expect = 9e-22
 Identities = 63/280 (22%), Positives = 127/280 (45%), Gaps = 11/280 (3%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIA--------ASS 82
           NS+ + T     L K+W   D   +L  +L GH   V ++       ++        AS 
Sbjct: 242 NSKMLATACWSGLCKLWSVPD--CNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299

Query: 83  SLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY 142
           + D  ++LW L++ + +  I+   V    + + P  ++L T  +     ++ +E+ ++  
Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359

Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
             +     +  IA+  DG    +G +D    ++D+ TG+ +  LEGH   I  + FSP+ 
Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419

Query: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF-VSSSSDKSVKVWDV 261
             + T S D   K++D++      T+  H + V  V F P   +F ++ + D + K+W  
Sbjct: 420 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479

Query: 262 GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
              + + T   H+ +V G+  + +G  I +   D+   ++
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 51/196 (26%), Positives = 96/196 (48%), Gaps = 3/196 (1%)

Query: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
           T++  P    LA+    G V ++ ++S +    ++     +  + + P G++L +   D 
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345

Query: 171 IINIFDI-ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229
              ++D+ A  ++LH  EGH+M +  + F  D  L  T   D + +++D++       L 
Sbjct: 346 SWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404

Query: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG-NGSK 288
           GH   +  + F P+  H  + S D + KVWD+  R CV+T   HQ+ V GVK+   +G+ 
Sbjct: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNF 464

Query: 289 IVSVGDDQEIHIYDCP 304
           +++   D    I+  P
Sbjct: 465 LLTGAYDNTAKIWTHP 480



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 36/155 (23%), Positives = 71/155 (45%), Gaps = 8/155 (5%)

Query: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL--------LVT 207
           +SP+ K LA+    G+  ++ +    LLHTL GH   + ++ F P S +        L +
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298

Query: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
            + DG +K++ +        + GH   V  V + P      ++  D+S ++WD+  +  +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358

Query: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
                H   V+ + ++ +GS   + G D    ++D
Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 393



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 8/123 (6%)

Query: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV--------LNVA 239
           G   PI    FSP+S++L TA   G  K++ V   NL  TL GH + V          V+
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
             P D +  S ++D SVK+W + +   V     H  +V  V ++ +G  + +   D+   
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 300 IYD 302
           ++D
Sbjct: 349 LWD 351



 Score = 32.0 bits (71), Expect = 0.70
 Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 9/104 (8%)

Query: 24  WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPI----A 79
           +G N   N   + TGS D+  KVW  R  R    +++  HQ  V  V      PI     
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFE---PIHGNFL 465

Query: 80  ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLAT 123
            + + D   ++W       +K++         L  S D Q +AT
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509



 Score = 32.0 bits (71), Expect = 0.70
 Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 8/63 (12%)

Query: 35  VVTGSLDDLVKVWK---WRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91
           ++TG+ D+  K+W    W   +     +L GH+  V+ +DIS    + A+ S D   +LW
Sbjct: 465 LLTGAYDNTAKIWTHPGWSPLK-----TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519

Query: 92  DLE 94
             E
Sbjct: 520 MAE 522


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score =  100 bits (249), Expect = 2e-21
 Identities = 55/190 (28%), Positives = 99/190 (52%), Gaps = 5/190 (2%)

Query: 117 DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
           DS+ L + +  GK+ I+   +  K +++  R  ++++ AY+P G Y+A G +D I +I++
Sbjct: 66  DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125

Query: 177 IATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
           + T     ++   L GH   +    F  DSQ+ VT+S D    ++D++ A    T +GH+
Sbjct: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHS 184

Query: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292
             V++++  PD   FVS + D S K+WD+    C  +F  H   +  V +  NG    + 
Sbjct: 185 GDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATG 244

Query: 293 GDDQEIHIYD 302
            DD    ++D
Sbjct: 245 SDDATCRLFD 254



 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 55/230 (23%), Positives = 100/230 (43%), Gaps = 5/230 (2%)

Query: 35  VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
           V  G LD++  ++  K R+  + +   L GH   +          I  SS  D    LWD
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG-DTTCALWD 170

Query: 93  LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
           +E  +Q  +      D  +L+ SPD +   +G       ++ +  G    S       I 
Sbjct: 171 IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDIN 230

Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           ++++ P+G   A+G+ D    +FD+   +  LL++ +     I S+ FS   +LL+   D
Sbjct: 231 AVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYD 290

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
           D    ++D    + AG L+GH + V  +    D     + S D  +++W+
Sbjct: 291 DFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 57/273 (20%), Positives = 127/273 (46%), Gaps = 13/273 (4%)

Query: 36  VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
           +T ++D + ++      ++  + +L GH   + ++   +   +  S+S D  + +WD   
Sbjct: 33  ITSNMDSVGRI------QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYT 86

Query: 96  GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-IL 152
             ++ +I        T A++P   Y+A G      +I+ +++  G    S +  G    L
Sbjct: 87  TNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYL 146

Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDG 212
           S     D   + + + D    ++DI T +   T  GH+  + SL+ SPD +  V+ + D 
Sbjct: 147 SCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDA 206

Query: 213 YIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD 272
             K++D++      + +GH S +  V+F P+   F + S D + +++D+     +   + 
Sbjct: 207 SSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYS 265

Query: 273 HQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
           H + + G   V ++ +G  +++  DD   +++D
Sbjct: 266 HDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score =  100 bits (249), Expect = 2e-21
 Identities = 52/197 (26%), Positives = 101/197 (51%), Gaps = 5/197 (2%)

Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
           + + +  DS+ L + +  GK+ I+   +  K +++  R  ++++ AY+P G ++A G +D
Sbjct: 59  YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118

Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
            I +I+ + T     ++   L GH   +    F  D+Q+ +T+S D    ++D++     
Sbjct: 119 NICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQI-ITSSGDTTCALWDIETGQQT 177

Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
              +GH+  V++++  PD   FVS + D S+K+WDV    C  TF  H+  +  V +  N
Sbjct: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237

Query: 286 GSKIVSVGDDQEIHIYD 302
           G    +  DD    ++D
Sbjct: 238 GYAFTTGSDDATCRLFD 254



 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 62/279 (22%), Positives = 130/279 (46%), Gaps = 13/279 (4%)

Query: 30  ENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
           +++ T +T  LD + ++      ++  + +L GH   + ++       +  S+S D  + 
Sbjct: 27  DSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80

Query: 90  LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTR 147
           +WD     ++ +I        T A++P   ++A G      +I+ +++  G    S +  
Sbjct: 81  IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELP 140

Query: 148 GKF-ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
           G    LS     D   + + + D    ++DI TG+      GH+  + SL+ +PD +  V
Sbjct: 141 GHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200

Query: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC 266
           + + D  IK++DV+ +    T  GH S +  VAF P+   F + S D + +++D+     
Sbjct: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260

Query: 267 VHTFFDHQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
           +   + H + + G   V ++ +G  +++  DD   +I+D
Sbjct: 261 L-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 55/230 (23%), Positives = 99/230 (43%), Gaps = 5/230 (2%)

Query: 35  VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
           V  G LD++  ++  K R+  + +   L GH   +          I  SS  D    LWD
Sbjct: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWD 170

Query: 93  LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
           +E G+Q         D  +L+ +PD +   +G     + ++ V       +       I 
Sbjct: 171 IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDIN 230

Query: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           ++A+ P+G    +G+ D    +FD+   +  L+++ +     I S+ FS   +LL+   D
Sbjct: 231 AVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYD 290

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
           D    I+D    + AG L+GH + V  +    D     + S D  +K+W+
Sbjct: 291 DFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 8/246 (3%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H  ++  + WG         + + S D  +KVW+  D  L       GH +  +++   +
Sbjct: 245 HTQSVTCLRWG-----GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
            L   A    +A +   DL+   Q   +    +  + L      + L +G+    + ++ 
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQ--ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWS 357

Query: 135 VESGKKEYSLDTRGKFILS-IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
               KK  +  T  + +++ + +SPD + +AS + D  I ++D  TGK L +L GH   +
Sbjct: 358 PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAV 417

Query: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD 253
             + +S DS+LLV+ S D  +K++DV+   LA  L GHA  V  V + PD     S   D
Sbjct: 418 YQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477

Query: 254 KSVKVW 259
           K +++W
Sbjct: 478 KCLRIW 483



 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 7/165 (4%)

Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
           SL+   + ++S+A+SP GKYLASG+ D  +  +D++T     T +GH   + S+++SPD 
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168

Query: 203 QLLVTASDDGYIKIYDVQHANLAG-TLSGHASWVLNVAF-----CPDDTHFVSSSSDKSV 256
           + L +   +G I ++D       G TL+GH+ W+  +++      P+  +  SSS D SV
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228

Query: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           ++WD     C      H   V  +++ G+G  + S   D+ I ++
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 60/191 (31%), Positives = 94/191 (49%), Gaps = 7/191 (3%)

Query: 59  SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
           SLEGH   V+SV  S T    AS S D  +R WDL       +         ++++SPD 
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168

Query: 119 QYLATGTHVGKVNIFGVESGKK-EYSLDTRGKFILSIAY-----SPDGKYLASGAIDGII 172
           + LA+G   G++ ++   +GK+   +L    K+I  +++     +P+ +Y+AS + DG +
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228

Query: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
            I+D   G+    L GH   +  L +  D  LL +AS D  IK++      L  TL GH 
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287

Query: 233 SWVLNVAFCPD 243
            WV  +A   D
Sbjct: 288 HWVNTMALSTD 298



 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 74/271 (27%), Positives = 124/271 (45%), Gaps = 10/271 (3%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           V + S D  V++W     R +    L GH   V  +       +  S+S D  I++W   
Sbjct: 219 VASSSKDGSVRIWDTTAGRCER--ILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAH 275

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV---GKVNIFGVESGKKEYSLDTRGKFI 151
           +G   +++        T+A S D   L TG        VN   ++   +E       ++ 
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYA-LRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334

Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           L     P+   L SG+ D  + ++  A  K  L  + GH   I  + FSPDS+++ +AS 
Sbjct: 335 LVRGQGPER--LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
           D  IK++D +      +L GH + V  +A+  D    VS SSD ++KVWDV  +      
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452

Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
             H D+V+ V ++ +G ++ S G D+ + I+
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 84.7 bits (208), Expect = 9e-17
 Identities = 80/340 (23%), Positives = 137/340 (40%), Gaps = 58/340 (17%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
           + H +A+ SVA+    K     + +GS D  V+ W    E     ++ +GH+  V+S+  
Sbjct: 111 EGHSEAVISVAFSPTGKY----LASGSGDTTVRFWDLSTETP--HFTCKGHRHWVLSISW 164

Query: 73  SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS-------PDSQYLATGT 125
           S      AS   +  I LWD   GKQ+    AG    W    S       P+ +Y+A+ +
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGH-SKWITGLSWEPLHANPECRYVASSS 223

Query: 126 HVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185
             G V I+   +G+ E  L    + +  + +  DG  L S + D  I ++    G L  T
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRT 282

Query: 186 LEGHAMPIRSLTFSPDSQL----------------------------------------- 204
           L+GH   + ++  S D  L                                         
Sbjct: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE 342

Query: 205 -LVTASDDGYIKIYD-VQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262
            LV+ SDD  + ++   +       ++GH + +  V F PD     S+S DKS+K+WD  
Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402

Query: 263 TRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           T   + +   H   V+ + ++ +   +VS   D  + ++D
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 6/131 (4%)

Query: 178 ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLN 237
           A  +   +LEGH+  + S+ FSP  + L + S D  ++ +D+       T  GH  WVL+
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161

Query: 238 VAFCPDDTHFVSSSSDKSVKVWDVGTRTCV-HTFFDHQDQVWGVKY-----NGNGSKIVS 291
           +++ PD     S   +  + +WD  T   V  T   H   + G+ +     N     + S
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221

Query: 292 VGDDQEIHIYD 302
              D  + I+D
Sbjct: 222 SSKDGSVRIWD 232


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           +V+GS D+ +KVW     +     +L GH  GV S  +   + I  S S D  +++W+ E
Sbjct: 276 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 331

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G+ I ++         +      + + +G+    + ++ +E+G+  + L      +  +
Sbjct: 332 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389

Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
            Y  DG+ + SGA D ++ ++D  T   LHTL+GH   + SL F  D   +V+ S D  I
Sbjct: 390 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 445

Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
           +++DV+  N   TL+GH S    +     D   VS ++D +VK+WD+ T  C+ T     
Sbjct: 446 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503

Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
            HQ  V  +++N N   +++  DD  + ++D
Sbjct: 504 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)

Query: 50  RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
           R  R+D  W          L+GH   V++  +        S S D  +++W    GK ++
Sbjct: 239 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 297

Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
           ++       W+     +   + +G+    + ++  E+G+  ++L      +  +      
Sbjct: 298 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 353

Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
           K + SG+ D  + ++DI TG+ LH L GH   +R + +  D + +V+ + D  +K++D +
Sbjct: 354 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 411

Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
                 TL GH + V ++ F  D  H VS S D S++VWDV T  C+HT   HQ    G+
Sbjct: 412 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 469

Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
           +   N   +VS   D  + I+D
Sbjct: 470 ELKDN--ILVSGNADSTVKIWD 489



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           VV+G+ D +VKVW    E      +L+GH   V S+       +  S SLD  IR+WD+E
Sbjct: 396 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 451

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G  I ++      + T         L +G     V I+ +++G+   +L    K   ++
Sbjct: 452 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 509

Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
                 K ++ + + DG + ++D+ TG+ +  L
Sbjct: 510 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 542



 Score = 35.4 bits (80), Expect = 0.063
 Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)

Query: 21  SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
           S+  G   K+N   +V+G+ D  VK+W  +  +  LQ +L+G   HQ  V  +  +    
Sbjct: 464 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 519

Query: 78  IAASSSLDAHIRLWDLENGKQIKSI 102
           I +S   D  ++LWDL+ G+ I+++
Sbjct: 520 ITSSD--DGTVKLWDLKTGEFIRNL 542


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           +V+GS D+ +KVW     +     +L GH  GV S  +   + I  S S D  +++W+ E
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 449

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G+ I ++         +      + + +G+    + ++ +E+G+  + L      +  +
Sbjct: 450 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507

Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
            Y  DG+ + SGA D ++ ++D  T   LHTL+GH   + SL F  D   +V+ S D  I
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 563

Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
           +++DV+  N   TL+GH S    +     D   VS ++D +VK+WD+ T  C+ T     
Sbjct: 564 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621

Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
            HQ  V  +++N N   +++  DD  + ++D
Sbjct: 622 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 650



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)

Query: 50  RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
           R  R+D  W          L+GH   V++  +        S S D  +++W    GK ++
Sbjct: 357 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 415

Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
           ++       W+     +   + +G+    + ++  E+G+  ++L      +  +      
Sbjct: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 471

Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
           K + SG+ D  + ++DI TG+ LH L GH   +R + +  D + +V+ + D  +K++D +
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529

Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
                 TL GH + V ++ F  D  H VS S D S++VWDV T  C+HT   HQ    G+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 587

Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
           +   N   +VS   D  + I+D
Sbjct: 588 ELKDN--ILVSGNADSTVKIWD 607



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           VV+G+ D +VKVW    E      +L+GH   V S+       +  S SLD  IR+WD+E
Sbjct: 514 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 569

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G  I ++      + T         L +G     V I+ +++G+   +L    K   ++
Sbjct: 570 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 627

Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
                 K ++ + + DG + ++D+ TG+ +  L
Sbjct: 628 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660



 Score = 35.4 bits (80), Expect = 0.063
 Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)

Query: 21  SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
           S+  G   K+N   +V+G+ D  VK+W  +  +  LQ +L+G   HQ  V  +  +    
Sbjct: 582 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 637

Query: 78  IAASSSLDAHIRLWDLENGKQIKSI 102
           I +S   D  ++LWDL+ G+ I+++
Sbjct: 638 ITSSD--DGTVKLWDLKTGEFIRNL 660


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 75/271 (27%), Positives = 135/271 (49%), Gaps = 17/271 (6%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           +V+GS D+ +KVW     +     +L GH  GV S  +   + I  S S D  +++W+ E
Sbjct: 314 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDNIII--SGSTDRTLKVWNAE 369

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G+ I ++         +      + + +G+    + ++ +E+G+  + L      +  +
Sbjct: 370 TGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427

Query: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
            Y  DG+ + SGA D ++ ++D  T   LHTL+GH   + SL F  D   +V+ S D  I
Sbjct: 428 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSI 483

Query: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF---F 271
           +++DV+  N   TL+GH S    +     D   VS ++D +VK+WD+ T  C+ T     
Sbjct: 484 RVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541

Query: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
            HQ  V  +++N N   +++  DD  + ++D
Sbjct: 542 KHQSAVTCLQFNKN--FVITSSDDGTVKLWD 570



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 20/262 (7%)

Query: 50  RDERLDLQWS---------LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
           R  R+D  W          L+GH   V++  +        S S D  +++W    GK ++
Sbjct: 277 RQHRIDTNWRRGELKSPKVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLR 335

Query: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160
           ++       W+     +   + +G+    + ++  E+G+  ++L      +  +      
Sbjct: 336 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-- 391

Query: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220
           K + SG+ D  + ++DI TG+ LH L GH   +R + +  D + +V+ + D  +K++D +
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 449

Query: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280
                 TL GH + V ++ F  D  H VS S D S++VWDV T  C+HT   HQ    G+
Sbjct: 450 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 507

Query: 281 KYNGNGSKIVSVGDDQEIHIYD 302
           +   N   +VS   D  + I+D
Sbjct: 508 ELKDN--ILVSGNADSTVKIWD 527



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 7/153 (4%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           VV+G+ D +VKVW    E      +L+GH   V S+       +  S SLD  IR+WD+E
Sbjct: 434 VVSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVV--SGSLDTSIRVWDVE 489

Query: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSI 154
            G  I ++      + T         L +G     V I+ +++G+   +L    K   ++
Sbjct: 490 TGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV 547

Query: 155 AYSPDGK-YLASGAIDGIINIFDIATGKLLHTL 186
                 K ++ + + DG + ++D+ TG+ +  L
Sbjct: 548 TCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 580



 Score = 35.4 bits (80), Expect = 0.063
 Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 9/85 (10%)

Query: 21  SVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG---HQLGVVSVDISHTLP 77
           S+  G   K+N   +V+G+ D  VK+W  +  +  LQ +L+G   HQ  V  +  +    
Sbjct: 502 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC-LQ-TLQGPNKHQSAVTCLQFNKNFV 557

Query: 78  IAASSSLDAHIRLWDLENGKQIKSI 102
           I +S   D  ++LWDL+ G+ I+++
Sbjct: 558 ITSSD--DGTVKLWDLKTGEFIRNL 580


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 98.2 bits (243), Expect = 8e-21
 Identities = 51/152 (33%), Positives = 79/152 (51%)

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           +  + +SP G  LASG+ D  + I+             H   +RS+ F  D Q  VTASD
Sbjct: 26  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85

Query: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
           D  +K++         +LS H +WV    F PD    VS+S DK+VK+WD  +R CVH++
Sbjct: 86  DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 145

Query: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
            +H   V  V ++ +G+ I + G D  + ++D
Sbjct: 146 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 63/245 (25%), Positives = 106/245 (43%), Gaps = 6/245 (2%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H DA+  V    N   +   + +GS D  V++W    +     +    H   V SV    
Sbjct: 22  HKDAVTCV----NFSPSGHLLASGSRDKTVRIWVPNVKGESTVF--RAHTATVRSVHFCS 75

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134
                 ++S D  +++W     K + S+           FSPD + + + +    V ++ 
Sbjct: 76  DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135

Query: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
             S +  +S    G F+  + + P G  +A+  +D  + ++D+ T +LL   + H+  + 
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195

Query: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254
            L+F P    L+TAS D  +KI D+    L  TL GH      VAF     +F S  SD+
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 255

Query: 255 SVKVW 259
            V VW
Sbjct: 256 QVMVW 260



 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 57/262 (21%), Positives = 119/262 (45%), Gaps = 2/262 (0%)

Query: 40  LDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQI 99
           +D  + VW  + +    +++  GH+  V  V+ S +  + AS S D  +R+W      + 
Sbjct: 1   MDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58

Query: 100 KSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPD 159
               A      ++ F  D Q   T +    V ++     K  +SL     ++    +SPD
Sbjct: 59  TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118

Query: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
           G+ + S + D  + ++D ++ + +H+   H   +  + F P    +  A  D  +K++DV
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178

Query: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG 279
           +   L      H++ V  ++F P   + +++SSD ++K+ D+     ++T   HQ     
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238

Query: 280 VKYNGNGSKIVSVGDDQEIHIY 301
           V ++  G    S G D+++ ++
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVW 260



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 56/220 (25%), Positives = 100/220 (45%), Gaps = 2/220 (0%)

Query: 84  LDAHIRLWDLENGKQIKSIDAGPVDAWTLA-FSPDSQYLATGTHVGKVNIFGVESGKKEY 142
           +D+ + +W ++   +      G  DA T   FSP    LA+G+    V I+      +  
Sbjct: 1   MDSCLMVWHMKPQSRAYRF-TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59

Query: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
                   + S+ +  DG+   + + D  + ++     K L +L  H   +R   FSPD 
Sbjct: 60  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119

Query: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262
           +L+V+ASDD  +K++D        +   H  +V  V F P  T   ++  D +VKVWDV 
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179

Query: 263 TRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
           T   +  +  H   V G+ ++ +G+ +++   D  + I D
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 56/166 (33%), Positives = 92/166 (55%), Gaps = 9/166 (5%)

Query: 114 FSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDTRGKF------ILSIAYSPDGKYLAS 165
           FSPD QYL TG+  G + ++   +GK  K+     +  F      +L + +S D + LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281

Query: 166 GAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
           GA DG I ++ I +G+ L   E  H+  +  L+FS DS  +++AS D  I+I+ ++    
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341

Query: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
                GH+S+V    F  D  + +S+SSD +VK+W++ T  C +TF
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTF 387



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 16/197 (8%)

Query: 81  SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL--------AFSPDSQYLATGTHVGKVNI 132
           + S+D  I +W+   GK  K +     D + +         FS D++ LATG   GK+ +
Sbjct: 231 TGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKV 290

Query: 133 FGVESGKKEYSLD-TRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM 191
           + ++SG+     +    K +  +++S D   + S + D  I I  + +GK L    GH+ 
Sbjct: 291 WKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSS 350

Query: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA------GTLSGHASWVLNVAFCP-DD 244
            +   TF+ D   +++AS DG +KI++++    +      G+ +G    V +V   P + 
Sbjct: 351 FVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNP 410

Query: 245 THFVSSSSDKSVKVWDV 261
            HFV  +   +V + ++
Sbjct: 411 EHFVVCNRSNTVVIMNM 427



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 37/164 (22%), Positives = 84/164 (51%), Gaps = 7/164 (4%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERL--DLQWSLEGHQL----GVVSVDISHTLPIAASSSL 84
           + + +VTGS+D  ++VW +   ++  DL++  + + +     V+ +  S    + A+ + 
Sbjct: 225 DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQ 284

Query: 85  DAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKVNIFGVESGKKEYS 143
           D  I++W +++G+ ++  +       T L+FS DS  + + +    + I G++SGK    
Sbjct: 285 DGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE 344

Query: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187
                 F+    ++ DG Y+ S + DG + I+++ T +  +T +
Sbjct: 345 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 9/127 (7%)

Query: 184 HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA--------SWV 235
           H   G    +    FSPD Q LVT S DG+I++++     +   L   A          V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267

Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF-FDHQDQVWGVKYNGNGSKIVSVGD 294
           L + F  D     + + D  +KVW + +  C+  F   H   V  + ++ + S+I+S   
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327

Query: 295 DQEIHIY 301
           DQ I I+
Sbjct: 328 DQTIRIH 334



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 52/253 (20%), Positives = 94/253 (37%), Gaps = 56/253 (22%)

Query: 16  DDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHT 75
           DDA+  + +      ++E + TG+ D  +KVWK +  +  L+     H  GV  +  S  
Sbjct: 264 DDAVLCMCFS----RDTEMLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSKD 318

Query: 76  LPIAASSSLDAHIRLWDLENGKQIKSIDA-----------------------GPVDAWTL 112
                S+S D  IR+  L++GK +K                           G V  W +
Sbjct: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378

Query: 113 AFSPDSQYLAT-----GTHVGKVNIFGVESGKKEYSLDTRGKFILSI------------- 154
             +  S    +     GT +   ++  +    + + +  R   ++ +             
Sbjct: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSG 438

Query: 155 ----------AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
                     A SP G+++     D ++  F   TGKL  TL  H   +  +   P   L
Sbjct: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNL 498

Query: 205 LVTASDDGYIKIY 217
           + T S+DG +K++
Sbjct: 499 IATYSEDGLLKLW 511


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 49/197 (24%), Positives = 99/197 (50%), Gaps = 5/197 (2%)

Query: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
           + + ++ DS+ L + +  GK+ ++   +  K +++  R  ++++ AY+P G ++A G +D
Sbjct: 59  YAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118

Query: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
            + +I+++ +     K+   L  H   +    F  D+ + VT+S D    ++D++     
Sbjct: 119 NMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNI-VTSSGDTTCALWDIETGQQK 177

Query: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
               GH    +++A  PD   F+S + D S K+WDV   TC  TF  H+  +  + +  N
Sbjct: 178 TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPN 237

Query: 286 GSKIVSVGDDQEIHIYD 302
           G  I +  DD    ++D
Sbjct: 238 GEAICTGSDDASCRLFD 254



 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 55/251 (21%), Positives = 108/251 (43%), Gaps = 9/251 (3%)

Query: 59  SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
           +L GH   + ++  +    +  S+S D  + +WD     ++ +I        T A++P  
Sbjct: 50  TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109

Query: 119 QYLATGTHVGKVNIFGVESG----KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
            ++A G      +I+ ++S     K    L     ++    +  D   + S   D    +
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCAL 168

Query: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234
           +DI TG+      GH     SL  SPD  L ++ + D   K++DV+      T +GH S 
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228

Query: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNGSKIVS 291
           +  + F P+     + S D S +++D+     +   F H+  + G   V ++ +G  + +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQEL-ICFSHESIICGITSVAFSLSGRLLFA 287

Query: 292 VGDDQEIHIYD 302
             DD   +++D
Sbjct: 288 GYDDFNCNVWD 298



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 7/231 (3%)

Query: 35  VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
           V  G LD++  ++  K R+  + +   L  H  G +S           +SS D    LWD
Sbjct: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHT-GYLSCCRFLDDNNIVTSSGDTTCALWD 170

Query: 93  LENGKQIKSIDAGPV-DAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
           +E G+Q K++  G   D  +LA SPD     +G       ++ V  G    +       I
Sbjct: 171 IETGQQ-KTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229

Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLL--HTLEGHAMPIRSLTFSPDSQLLVTAS 209
            +I + P+G+ + +G+ D    +FD+   + L   + E     I S+ FS   +LL    
Sbjct: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGY 289

Query: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
           DD    ++D   +   G LSGH + V  +    D     + S D  +K+W+
Sbjct: 290 DDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 4/190 (2%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
           +   +VT S D    +W    E    +    GH    +S+ +S    +  S + DA  +L
Sbjct: 153 DDNNIVTSSGDTTCALWDI--ETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKL 210

Query: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE--YSLDTRG 148
           WD+  G   ++      D   + F P+ + + TG+      +F + + ++   +S ++  
Sbjct: 211 WDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESII 270

Query: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208
             I S+A+S  G+ L +G  D   N++D    + +  L GH   +  L  + D   + T 
Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330

Query: 209 SDDGYIKIYD 218
           S D ++KI++
Sbjct: 331 SWDSFLKIWN 340


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71
           +AH+D +   A+ T+ +     + T S+D  VK+W      L   +     Q+      +
Sbjct: 654 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 709

Query: 72  ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130
            SH L +A  SS D  ++LWDL N K+ ++   G  ++     FSPD + LA+ +  G +
Sbjct: 710 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767

Query: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176
            ++   S  +  S++ + +F L++              ++S DG  +   A + I  +FD
Sbjct: 768 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 825

Query: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           I T  LL  +  GH   I+   FSP + L V A     +++++    +      GH SWV
Sbjct: 826 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 885

Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260
             V F PD + F++SS D+++++W+
Sbjct: 886 HGVMFSPDGSSFLTSSDDQTIRLWE 910



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173
           FS D Q +A+      + +F  E+G+K   +      +L  A+S D +++A+ ++D  + 
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682

Query: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231
           I++  TG+L+HT + H+  +    F+  S   LL T S D ++K++D+       T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742

Query: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
            + V +  F PDD    S S+D ++K+WD
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWD 771



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 63/256 (24%), Positives = 106/256 (41%), Gaps = 54/256 (21%)

Query: 8    LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW------------------ 49
            +F+    H   +W + +  ++K    T+++ S D  ++VW W                  
Sbjct: 995  IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1050

Query: 50   ---RDERLDLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHI 88
               ++ RL L WS +G                  HQ  V+S DISH     +S+S D   
Sbjct: 1051 RLLKNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1109

Query: 89   RLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------K 140
            ++W  +    +  +          AFS DS  LATG   G++ I+ V +G+         
Sbjct: 1110 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1169

Query: 141  EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
            E    T G ++  + +SPDGK L S    G I  +++ TG+   T   +   ++ +  SP
Sbjct: 1170 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1227

Query: 201  DSQLLVTASDDGYIKI 216
            D +  VT  + G + I
Sbjct: 1228 DFKTYVTVDNLGILYI 1243



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 62/304 (20%), Positives = 136/304 (44%), Gaps = 23/304 (7%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H DA++   +     E+ + + +   D  ++V+K       L+  ++ H+  V+    S 
Sbjct: 614 HTDAVYHACFS----EDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFST 667

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL--ATGTHVGKVNI 132
                A+ S+D  +++W+   G+ + + D          F+  S +L  ATG+    + +
Sbjct: 668 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727

Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL------ 186
           + +   +   ++      +    +SPD K LAS + DG + ++D  +     ++      
Sbjct: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 787

Query: 187 -------EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-SGHASWVLNV 238
                  E   + ++  ++S D   ++ A+ +  I ++D+  + L G + +GH S +   
Sbjct: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYC 846

Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298
            F P +   V + S   V++W+  +R+ V     H   V GV ++ +GS  ++  DDQ I
Sbjct: 847 DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 906

Query: 299 HIYD 302
            +++
Sbjct: 907 RLWE 910



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)

Query: 87   HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144
            HIR   L NG+  QI  +    V    L  SP  QY+A G   G + I  + + +   S 
Sbjct: 942  HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 999

Query: 145  DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
                K +  I ++ D K L S + D  I +++    K +  L GH   ++      +S+L
Sbjct: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1058

Query: 205  LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264
            L + S DG +K++++   N       H   VL+     D T F S+S+DK+ K+W     
Sbjct: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117

Query: 265  TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
              +H    H   V    ++ + + + +  D+ EI I++
Sbjct: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)

Query: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71
           +AH+D +   A+ T+ +     + T S+D  VK+W      L   +     Q+      +
Sbjct: 643 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 698

Query: 72  ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130
            SH L +A  SS D  ++LWDL N K+ ++   G  ++     FSPD + LA+ +  G +
Sbjct: 699 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756

Query: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176
            ++   S  +  S++ + +F L++              ++S DG  +   A + I  +FD
Sbjct: 757 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 814

Query: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
           I T  LL  +  GH   I+   FSP + L V A     +++++    +      GH SWV
Sbjct: 815 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 874

Query: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260
             V F PD + F++SS D+++++W+
Sbjct: 875 HGVMFSPDGSSFLTSSDDQTIRLWE 899



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173
           FS D Q +A+      + +F  E+G+K   +      +L  A+S D +++A+ ++D  + 
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671

Query: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231
           I++  TG+L+HT + H+  +    F+  S   LL T S D ++K++D+       T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731

Query: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
            + V +  F PDD    S S+D ++K+WD
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWD 760



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 63/256 (24%), Positives = 106/256 (41%), Gaps = 54/256 (21%)

Query: 8    LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW------------------ 49
            +F+    H   +W + +  ++K    T+++ S D  ++VW W                  
Sbjct: 984  IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1039

Query: 50   ---RDERLDLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHI 88
               ++ RL L WS +G                  HQ  V+S DISH     +S+S D   
Sbjct: 1040 RLLKNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098

Query: 89   RLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------K 140
            ++W  +    +  +          AFS DS  LATG   G++ I+ V +G+         
Sbjct: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158

Query: 141  EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
            E    T G ++  + +SPDGK L S    G I  +++ TG+   T   +   ++ +  SP
Sbjct: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1216

Query: 201  DSQLLVTASDDGYIKI 216
            D +  VT  + G + I
Sbjct: 1217 DFKTYVTVDNLGILYI 1232



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 62/304 (20%), Positives = 136/304 (44%), Gaps = 23/304 (7%)

Query: 15  HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74
           H DA++   +     E+ + + +   D  ++V+K       L+  ++ H+  V+    S 
Sbjct: 603 HTDAVYHACFS----EDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFST 656

Query: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL--ATGTHVGKVNI 132
                A+ S+D  +++W+   G+ + + D          F+  S +L  ATG+    + +
Sbjct: 657 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716

Query: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL------ 186
           + +   +   ++      +    +SPD K LAS + DG + ++D  +     ++      
Sbjct: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776

Query: 187 -------EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-SGHASWVLNV 238
                  E   + ++  ++S D   ++ A+ +  I ++D+  + L G + +GH S +   
Sbjct: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYC 835

Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298
            F P +   V + S   V++W+  +R+ V     H   V GV ++ +GS  ++  DDQ I
Sbjct: 836 DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 895

Query: 299 HIYD 302
            +++
Sbjct: 896 RLWE 899



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)

Query: 87   HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144
            HIR   L NG+  QI  +    V    L  SP  QY+A G   G + I  + + +   S 
Sbjct: 931  HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 988

Query: 145  DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
                K +  I ++ D K L S + D  I +++    K +  L GH   ++      +S+L
Sbjct: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1047

Query: 205  LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264
            L + S DG +K++++   N       H   VL+     D T F S+S+DK+ K+W     
Sbjct: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106

Query: 265  TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
              +H    H   V    ++ + + + +  D+ EI I++
Sbjct: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144


>gi|189571685 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           + T SLD  ++++  RD        L+ H   V     S +  I AS S D    LW+ E
Sbjct: 25  LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84

Query: 95  NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
           NG+ +  ++     PV      FSPDS  LA+G   G V ++  +S K       +   +
Sbjct: 85  NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142

Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203
            + A+SP+G +  +G+  G + ++D    + LH+ + H + I    FS  P S       
Sbjct: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201

Query: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254
              L +   D  +KI+ V   ++ G       TLSGH + VL  AF  D    VS S DK
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261

Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           SV V+D  T   +HT   H   V    +  N   + +   D+ ++I+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)

Query: 80  ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
           AS + D  + LW+ ++ K  +  S+  G + A   AFSP+  +  TG+  G + ++  + 
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170

Query: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183
                +K + L   G      +  P  DG+       LAS   D  + I+ ++   +L  
Sbjct: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227

Query: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238
                 TL GH  P+ +  FS D Q+LV+ S D  + +YD    N+  TL+ H  +V   
Sbjct: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287

Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274
           AF P+     + S DK+V +W     T C     +HQ
Sbjct: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
           N    VTGS    + VW   D+++    S + H LG+   D S + P++         RL
Sbjct: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205

Query: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
                  Q+K         W ++F+               +I G E  K + +L      
Sbjct: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           +L+ A+S DG+ L SG++D  + ++D  T  +LHTL  H   + +  F+P++ LL T S 
Sbjct: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301

Query: 211 DGYIKIY 217
           D  + I+
Sbjct: 302 DKTVNIW 308



 Score = 30.8 bits (68), Expect = 1.6
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)

Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238
           KL+HTL  H   +    FS    LL T S D  I++Y ++         L  H   V   
Sbjct: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60

Query: 239 AFCPDDTHFVSSSSDKSVKVWD 260
            F P      S S+D +  +W+
Sbjct: 61  CFSPSGHILASCSTDGTTVLWN 82


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)

Query: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
           + T SLD  ++++  RD        L+ H   V     S +  I AS S D    LW+ E
Sbjct: 25  LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84

Query: 95  NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
           NG+ +  ++     PV      FSPDS  LA+G   G V ++  +S K       +   +
Sbjct: 85  NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142

Query: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203
            + A+SP+G +  +G+  G + ++D    + LH+ + H + I    FS  P S       
Sbjct: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201

Query: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254
              L +   D  +KI+ V   ++ G       TLSGH + VL  AF  D    VS S DK
Sbjct: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261

Query: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
           SV V+D  T   +HT   H   V    +  N   + +   D+ ++I+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308



 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)

Query: 80  ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
           AS + D  + LW+ ++ K  +  S+  G + A   AFSP+  +  TG+  G + ++  + 
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170

Query: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183
                +K + L   G      +  P  DG+       LAS   D  + I+ ++   +L  
Sbjct: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227

Query: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238
                 TL GH  P+ +  FS D Q+LV+ S D  + +YD    N+  TL+ H  +V   
Sbjct: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287

Query: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274
           AF P+     + S DK+V +W     T C     +HQ
Sbjct: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)

Query: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
           N    VTGS    + VW   D+++    S + H LG+   D S + P++         RL
Sbjct: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205

Query: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
                  Q+K         W ++F+               +I G E  K + +L      
Sbjct: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241

Query: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
           +L+ A+S DG+ L SG++D  + ++D  T  +LHTL  H   + +  F+P++ LL T S 
Sbjct: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301

Query: 211 DGYIKIY 217
           D  + I+
Sbjct: 302 DKTVNIW 308



 Score = 30.8 bits (68), Expect = 1.6
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)

Query: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238
           KL+HTL  H   +    FS    LL T S D  I++Y ++         L  H   V   
Sbjct: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60

Query: 239 AFCPDDTHFVSSSSDKSVKVWD 260
            F P      S S+D +  +W+
Sbjct: 61  CFSPSGHILASCSTDGTTVLWN 82


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,626,192
Number of Sequences: 37866
Number of extensions: 484328
Number of successful extensions: 4184
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 264
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 1089
Number of HSP's gapped (non-prelim): 1559
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press