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Search of human proteins with 4826730
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826730 FK506 binding protein 12-rapamycin associated
protein 1 [Homo sapiens]
(2549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 5078 0.0
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 228 4e-59
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 197 8e-50
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 197 8e-50
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 177 2e-43
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 177 2e-43
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 175 6e-43
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 149 3e-35
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 140 2e-32
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 140 2e-32
gi|4507691 transformation/transcription domain-associated protei... 73 3e-12
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 72 7e-12
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 64 2e-09
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 59 5e-08
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 58 1e-07
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 56 4e-07
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 55 9e-07
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 54 3e-06
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 51 2e-05
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 50 3e-05
gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad... 50 4e-05
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 48 1e-04
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 48 1e-04
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 48 1e-04
gi|62460637 importin 4 [Homo sapiens] 45 7e-04
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 45 0.001
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens] 44 0.003
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 40 0.038
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 39 0.066
gi|19923142 karyopherin beta 1 [Homo sapiens] 39 0.086
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 5078 bits (13171), Expect = 0.0
Identities = 2549/2549 (100%), Positives = 2549/2549 (100%)
Query: 1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES 60
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
Sbjct: 1 MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES 60
Query: 61 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP 120
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
Sbjct: 61 TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP 120
Query: 121 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP 180
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
Sbjct: 121 VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP 180
Query: 181 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE 240
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
Sbjct: 181 TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE 240
Query: 241 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC 300
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
Sbjct: 241 AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC 300
Query: 301 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR 360
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
Sbjct: 301 KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR 360
Query: 361 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV 420
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
Sbjct: 361 CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV 420
Query: 421 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA 480
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
Sbjct: 421 LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA 480
Query: 481 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL 540
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
Sbjct: 481 TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL 540
Query: 541 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT 600
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
Sbjct: 541 KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT 600
Query: 601 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL 660
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
Sbjct: 601 QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL 660
Query: 661 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS 720
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
Sbjct: 661 VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS 720
Query: 721 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI 780
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
Sbjct: 721 MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI 780
Query: 781 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA 840
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
Sbjct: 781 LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA 840
Query: 841 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK 900
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
Sbjct: 841 LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK 900
Query: 901 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR 960
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
Sbjct: 901 VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR 960
Query: 961 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV 1020
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
Sbjct: 961 DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV 1020
Query: 1021 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR 1080
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
Sbjct: 1021 SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR 1080
Query: 1081 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD 1140
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
Sbjct: 1081 VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD 1140
Query: 1141 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV 1200
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
Sbjct: 1141 RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV 1200
Query: 1201 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV 1260
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
Sbjct: 1201 RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV 1260
Query: 1261 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA 1320
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
Sbjct: 1261 STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA 1320
Query: 1321 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI 1380
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
Sbjct: 1321 AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI 1380
Query: 1381 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF 1440
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
Sbjct: 1381 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF 1440
Query: 1441 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK 1500
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
Sbjct: 1441 GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK 1500
Query: 1501 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA 1560
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
Sbjct: 1501 WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA 1560
Query: 1561 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW 1620
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
Sbjct: 1561 QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW 1620
Query: 1621 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD 1680
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
Sbjct: 1621 ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD 1680
Query: 1681 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK 1740
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
Sbjct: 1681 PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK 1740
Query: 1741 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA 1800
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
Sbjct: 1741 QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA 1800
Query: 1801 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP 1860
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
Sbjct: 1801 VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP 1860
Query: 1861 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN 1920
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
Sbjct: 1861 TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN 1920
Query: 1921 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS 1980
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
Sbjct: 1921 EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS 1980
Query: 1981 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG 2040
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
Sbjct: 1981 KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG 2040
Query: 2041 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA 2100
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
Sbjct: 2041 ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA 2100
Query: 2101 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL 2160
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
Sbjct: 2101 WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL 2160
Query: 2161 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL 2220
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
Sbjct: 2161 QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL 2220
Query: 2221 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL 2280
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
Sbjct: 2221 SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL 2280
Query: 2281 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH 2340
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
Sbjct: 2281 MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH 2340
Query: 2341 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC 2400
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
Sbjct: 2341 PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC 2400
Query: 2401 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG 2460
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
Sbjct: 2401 HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG 2460
Query: 2461 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD 2520
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
Sbjct: 2461 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD 2520
Query: 2521 VPTQVELLIKQATSHENLCQCYIGWCPFW 2549
VPTQVELLIKQATSHENLCQCYIGWCPFW
Sbjct: 2521 VPTQVELLIKQATSHENLCQCYIGWCPFW 2549
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 228 bits (582), Expect = 4e-59
Identities = 172/644 (26%), Positives = 284/644 (44%), Gaps = 124/644 (19%)
Query: 1903 TLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLT 1962
TLR+L L H ++ + L G++ W +IPQL +R++ P V + I LL
Sbjct: 1789 TLRLLRLLVK--HAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLC 1846
Query: 1963 DIGRYHPQALIYPLTVASKSTTTARHNAANK----------------ILKNMCEHSN--- 2003
+ + P ++YP V + S ++ + NK +L + CE +
Sbjct: 1847 RVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPA 1906
Query: 2004 ------------------------------------TLVQQAMMVSEELIRVAILWHEMW 2027
T+V Q M+ EL RV +LW E+W
Sbjct: 1907 SQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELW 1966
Query: 2028 HEGL---------------EEASRLYFG-----ERNVKGMFE-----------VLEPLHA 2056
L +E R+ E + M E LE + +
Sbjct: 1967 LGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRS 2026
Query: 2057 MMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLP 2116
+ +T E F YG + A E K N +W + + + ++
Sbjct: 2027 ITAAPAETPHEKWFQDNYGDAIENALE---KLKTPLNPAKPGSSWIPFKEIMLSLQQRAQ 2083
Query: 2117 QLTS--LELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTL 2174
+ S L L+ +SP L + E+A+PG + I S+ ++ ++ +K +P+KL
Sbjct: 2084 KRASYILRLEEISPWLAAMTNTEIALPGEVSARDTVT-IHSVGGTITILPTKTKPKKLLF 2142
Query: 2175 MGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNS 2234
+GS+G + +L KG EDL DER+MQ +VNT+ A + Y+V PL T S
Sbjct: 2143 LGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRS 2202
Query: 2235 GLIGWVPHCDTLHALIRDYREKKK------------------ILLNIEHRIMLRMAPDYD 2276
GLI WV L L + +++++ I+ ++ P
Sbjct: 2203 GLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALK 2262
Query: 2277 HLTLMQKVE-----------VFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLA 2325
+ L V V E + T + LAK LW + + W+ +Y RS A
Sbjct: 2263 TVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTA 2322
Query: 2326 VMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTN 2385
VMSMVGYI+GLGDRH N+++D +G+++HID+ CFE + + PEK+PFR+T+ +
Sbjct: 2323 VMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL-RVPEKVPFRMTQNIET 2381
Query: 2386 AMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW 2429
A+ VTG++G +R++C V+ ++R +++++ +LEAFVYDPL++W
Sbjct: 2382 ALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
Score = 47.0 bits (110), Expect = 2e-04
Identities = 22/52 (42%), Positives = 32/52 (61%)
Query: 2494 NKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
N A+ + RV+ KL GRD + + V QV+ +IK+AT+ +NL Q Y GW
Sbjct: 3606 NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGW 3657
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 197 bits (502), Expect = 8e-50
Identities = 124/390 (31%), Positives = 198/390 (50%), Gaps = 47/390 (12%)
Query: 2160 LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN 2219
++++ S Q+P+K++L GS+G ++ + K +DLR+D R+M+ L+N L D S R+
Sbjct: 2300 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 2359
Query: 2220 LSIQRYAVIPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHL 2278
L I+ YAVIPL+ G+I WV + L ++ + Y+EK + E LR
Sbjct: 2360 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKE----LRQCMLPKSA 2415
Query: 2279 TLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGD 2338
L +K++VF + + P W+ R+ Y RS AVMSMVGYILGLGD
Sbjct: 2416 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 2475
Query: 2339 RHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRI 2398
RH N++ D L+G+ +H+DF F T E PE +PFRLT + N M G +G +R
Sbjct: 2476 RHGENILFDSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRR 2534
Query: 2399 TCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEIL 2458
C M ++R+ ++ +M+VL+ F++DPL+ W KG+ ++
Sbjct: 2535 ACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKAPLN------------- 2578
Query: 2459 DGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDT 2518
E GE ++K T V + ++ +Q + + R+++TG
Sbjct: 2579 ---ETGEVVNEKAKTHVLDI----------------EQRLQGVIKTRNRVTGL------P 2613
Query: 2519 LDVPTQVELLIKQATSHENLCQCYIGWCPF 2548
L + V LI++AT LCQ Y+GW P+
Sbjct: 2614 LSIEGHVHYLIQEATDENLLCQMYLGWTPY 2643
Score = 49.7 bits (117), Expect = 4e-05
Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 29/307 (9%)
Query: 1389 KCRAYAKALHYKE--LEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQ 1446
+ +AY +A+ + E + +K L L + + +P+ AGV K L+ Q
Sbjct: 1647 RSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGV-SAIRKAEPSLKEQ 1705
Query: 1447 ATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVND 1506
+E L DA YD+ + D G ++ + LG+ + Q ++
Sbjct: 1706 ILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSE 1765
Query: 1507 ETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDK 1566
T ++ AAW L QWD +E Y DG + L Q L S ++ I
Sbjct: 1766 WTD-ELNTYRVEAAWKLSQWDLVENYLAA------DGKSTTWSVRLGQLLLSAKKRDITA 1818
Query: 1567 ARD---LLDAE----LTAMAGE--SYSRAYGAMVSCHMLSELEEVIQ--YKLVP-ERREI 1614
D L+ AE L+A + E SY R Y +V HML ELE I+ ++ P + +
Sbjct: 1819 FYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQE 1878
Query: 1615 IRQIWWERLQGCQRIVEDWQKILMVRSLVVS-----PHEDM--RTWLKYASLCGKSGRLA 1667
W RL+ Q + IL +R ++S + +M WL+ A + K+G
Sbjct: 1879 DSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQ 1938
Query: 1668 LAHKTLV 1674
A+ L+
Sbjct: 1939 TAYNALL 1945
Score = 41.2 bits (95), Expect = 0.013
Identities = 37/151 (24%), Positives = 63/151 (41%), Gaps = 24/151 (15%)
Query: 1893 SLSRGNNL--QDTLRVLTLWFDYG----HWP---------------DVNEALVEGVKAIQ 1931
SL GN Q R+LTLW DYG W +N+ + E +
Sbjct: 2075 SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLA 2134
Query: 1932 IDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAA 1991
+L QLI+RI V ++ +++ + +PQ ++ +T SKS+ R N
Sbjct: 2135 PYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRC 2194
Query: 1992 NKILKNMCEHSNTL---VQQAMMVSEELIRV 2019
+IL +L V A ++++L+ +
Sbjct: 2195 KEILNKAIHMKKSLEKFVGDATRLTDKLLEL 2225
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 197 bits (502), Expect = 8e-50
Identities = 124/390 (31%), Positives = 198/390 (50%), Gaps = 47/390 (12%)
Query: 2160 LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN 2219
++++ S Q+P+K++L GS+G ++ + K +DLR+D R+M+ L+N L D S R+
Sbjct: 42 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 101
Query: 2220 LSIQRYAVIPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHL 2278
L I+ YAVIPL+ G+I WV + L ++ + Y+EK + E LR
Sbjct: 102 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKE----LRQCMLPKSA 157
Query: 2279 TLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGD 2338
L +K++VF + + P W+ R+ Y RS AVMSMVGYILGLGD
Sbjct: 158 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 217
Query: 2339 RHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRI 2398
RH N++ D L+G+ +H+DF F T E PE +PFRLT + N M G +G +R
Sbjct: 218 RHGENILFDSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRR 276
Query: 2399 TCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEIL 2458
C M ++R+ ++ +M+VL+ F++DPL+ W KG+ ++
Sbjct: 277 ACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKAPLN------------- 320
Query: 2459 DGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDT 2518
E GE ++K T V + ++ +Q + + R+++TG
Sbjct: 321 ---ETGEVVNEKAKTHVLDI----------------EQRLQGVIKTRNRVTGL------P 355
Query: 2519 LDVPTQVELLIKQATSHENLCQCYIGWCPF 2548
L + V LI++AT LCQ Y+GW P+
Sbjct: 356 LSIEGHVHYLIQEATDENLLCQMYLGWTPY 385
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 177 bits (448), Expect = 2e-43
Identities = 121/407 (29%), Positives = 199/407 (48%), Gaps = 45/407 (11%)
Query: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
++ IQS ++ P+ + +GS+G E L+KG +DLRQD + Q+F + NTLL
Sbjct: 1332 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 1391
Query: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGW-----------VPHCDTLHALIRDYREKKK 2258
+ + ++ L+I Y V+PLS SG++ W V + D H + YR
Sbjct: 1392 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH---KRYRPNDF 1448
Query: 2259 ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT 2318
+ ++M ++ +K EVF N K +WF++R
Sbjct: 1449 SAFQCQKKMMEVQKKSFE-----EKYEVFMDVCQNFQ-PVFRYFCMEKFLDPAIWFEKRL 1502
Query: 2319 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 2378
YTRS+A S+VGYILGLGDRH N++++ S +++HID G FE PE +PFR
Sbjct: 1503 AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFR 1561
Query: 2379 LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438
LTR + + M +TG++G +R C MEV+R +++++ ++E +YDPL +W + N
Sbjct: 1562 LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM---NPLK 1618
Query: 2439 NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI 2498
+ R + E+ + + K+ + + +S NK A
Sbjct: 1619 ALYLQQRPE-----DETELHPTLNADDQECKRNLSDIDQS--------------FNKVAE 1659
Query: 2499 QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
+++ R+++KL G L V QV LLI+QA +NL + + GW
Sbjct: 1660 RVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW 1704
Score = 33.5 bits (75), Expect = 2.8
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 3/153 (1%)
Query: 1450 YEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQ 1509
YE W ALV YD ++T G ++ L+ LG L + N +
Sbjct: 688 YEHEAMWGKALVTYD--LETAIPSSTRQAGIIQALQNLGLCHILSVYL-KGLDYENKDWC 744
Query: 1510 AKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD 1569
++ + AAW QWD + + ++ + Y A+ +L FS + + AR
Sbjct: 745 PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV 804
Query: 1570 LLDAELTAMAGESYSRAYGAMVSCHMLSELEEV 1602
E+ + ES Y + + ELE +
Sbjct: 805 KEVEEMCKRSLESVYSLYPTLSRLQAIGELESI 837
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 177 bits (448), Expect = 2e-43
Identities = 121/407 (29%), Positives = 199/407 (48%), Gaps = 45/407 (11%)
Query: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
++ IQS ++ P+ + +GS+G E L+KG +DLRQD + Q+F + NTLL
Sbjct: 2680 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 2739
Query: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGW-----------VPHCDTLHALIRDYREKKK 2258
+ + ++ L+I Y V+PLS SG++ W V + D H + YR
Sbjct: 2740 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH---KRYRPNDF 2796
Query: 2259 ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT 2318
+ ++M ++ +K EVF N K +WF++R
Sbjct: 2797 SAFQCQKKMMEVQKKSFE-----EKYEVFMDVCQNFQ-PVFRYFCMEKFLDPAIWFEKRL 2850
Query: 2319 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 2378
YTRS+A S+VGYILGLGDRH N++++ S +++HID G FE PE +PFR
Sbjct: 2851 AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFR 2909
Query: 2379 LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438
LTR + + M +TG++G +R C MEV+R +++++ ++E +YDPL +W + N
Sbjct: 2910 LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM---NPLK 2966
Query: 2439 NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI 2498
+ R + E+ + + K+ + + +S NK A
Sbjct: 2967 ALYLQQRPE-----DETELHPTLNADDQECKRNLSDIDQS--------------FNKVAE 3007
Query: 2499 QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
+++ R+++KL G L V QV LLI+QA +NL + + GW
Sbjct: 3008 RVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW 3052
Score = 33.5 bits (75), Expect = 2.8
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 3/153 (1%)
Query: 1450 YEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQ 1509
YE W ALV YD ++T G ++ L+ LG L + N +
Sbjct: 2036 YEHEAMWGKALVTYD--LETAIPSSTRQAGIIQALQNLGLCHILSVYL-KGLDYENKDWC 2092
Query: 1510 AKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD 1569
++ + AAW QWD + + ++ + Y A+ +L FS + + AR
Sbjct: 2093 PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV 2152
Query: 1570 LLDAELTAMAGESYSRAYGAMVSCHMLSELEEV 1602
E+ + ES Y + + ELE +
Sbjct: 2153 KEVEEMCKRSLESVYSLYPTLSRLQAIGELESI 2185
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 175 bits (443), Expect = 6e-43
Identities = 120/407 (29%), Positives = 199/407 (48%), Gaps = 45/407 (11%)
Query: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
++ IQS ++ P+ + +GS+G E L+KG +DLRQD + Q+F + NTLL
Sbjct: 2558 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 2617
Query: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGW-----------VPHCDTLHALIRDYREKKK 2258
+ + ++ L+I Y V+PLS SG++ W V + D H + YR
Sbjct: 2618 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH---KRYRPNDF 2674
Query: 2259 ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT 2318
+ ++M ++ +K EVF N K +WF++R
Sbjct: 2675 SAFQCQKKMMEVQKKSFE-----EKYEVFMDVCQNFQ-PVFRYFCMEKFLDPAIWFEKRL 2728
Query: 2319 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 2378
YTRS+A S+VGYILGLGDRH N++++ S +++HID G FE PE +PFR
Sbjct: 2729 AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFR 2787
Query: 2379 LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438
LTR + + M +TG++G +R C MEV+R +++++ ++E +YDPL +W + N
Sbjct: 2788 LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM---NPLK 2844
Query: 2439 NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI 2498
+ R + E+ + + K+ + + +S +K A
Sbjct: 2845 ALYLQQRPE-----DETELHPTLNADDQECKRNLSDIDQS--------------FDKVAE 2885
Query: 2499 QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
+++ R+++KL G L V QV LLI+QA +NL + + GW
Sbjct: 2886 RVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW 2930
Score = 33.5 bits (75), Expect = 2.8
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 3/153 (1%)
Query: 1450 YEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQ 1509
YE W ALV YD ++T G ++ L+ LG L + N +
Sbjct: 1914 YEHEAMWGKALVTYD--LETAIPSSTRQAGIIQALQNLGLCHILSVYL-KGLDYENKDWC 1970
Query: 1510 AKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD 1569
++ + AAW QWD + + ++ + Y A+ +L FS + + AR
Sbjct: 1971 PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV 2030
Query: 1570 LLDAELTAMAGESYSRAYGAMVSCHMLSELEEV 1602
E+ + ES Y + + ELE +
Sbjct: 2031 KEVEEMCKRSLESVYSLYPTLSRLQAIGELESI 2063
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 149 bits (377), Expect = 3e-35
Identities = 135/544 (24%), Positives = 251/544 (46%), Gaps = 53/544 (9%)
Query: 1924 VEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKST 1983
+ V Q +W I ++A +D + + + + +I +PQA++YP ++S+S
Sbjct: 3487 ISSVPCWQFISW---ISHMVALLDKDQAVA---VQHSVEEITDNYPQAIVYPFIISSESY 3540
Query: 1984 TTARHNAANKILKNMCEHSNTL-----VQQAMMVSEELIRVAILWHEMWHEGLEEASRLY 2038
+ + +K + + + L +Q + ++L +L+ + ++ E ++
Sbjct: 3541 SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP 3600
Query: 2039 FGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGN----- 2093
++N++ M+E + + F Q +G+ E+ + + K G+
Sbjct: 3601 VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGK------EFDKHFGKGGSKLLRM 3654
Query: 2094 -VKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPN-QPI- 2150
+ D ++ + SK L K+ R+ EL +PG YD +P+
Sbjct: 3655 KLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRN-ELEIPGQYDGRGKPLP 3713
Query: 2151 ---IRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNT 2207
+RI + V+ S +RP+++ + G + E FL+KG EDLRQD+RV QLF ++N
Sbjct: 3714 EYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNG 3773
Query: 2208 LLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRD--YREKKKILLN--- 2262
+LA D ++ L ++ Y+V+P+++ GLI W+ + TL L+ + +E+K L+
Sbjct: 3774 ILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPR 3833
Query: 2263 ---IEHRIML-RMAPDYDHLTLM---------QKVEVFEHAVNNTAGDDLAKLLWLKSPS 2309
E++ L +M+ +D M + V F + D L + S S
Sbjct: 3834 APPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTS 3893
Query: 2310 SEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTRE 2369
E + R+++ S A++ + +ILG+GDRH +N M+ +G ++ IDFG F A
Sbjct: 3894 PEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFL 3953
Query: 2370 KFPEKIPFRLTRMLTN---AMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPL 2426
PE +PFRLTR N M+ TGL Y I H + R + ++ FV +P
Sbjct: 3954 PVPELMPFRLTRQFINLMLPMKETGL--MYSIMVH-ALRAFRSDPGLLTNTMDVFVKEPS 4010
Query: 2427 LNWR 2430
+W+
Sbjct: 4011 FDWK 4014
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 140 bits (352), Expect = 2e-32
Identities = 127/526 (24%), Positives = 239/526 (45%), Gaps = 48/526 (9%)
Query: 1924 VEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKST 1983
+ V Q +W I ++A +D + + + + +I +PQA++YP ++S+S
Sbjct: 3487 ISSVPCWQFISW---ISHMVALLDKDQAVA---VQHSVEEITDNYPQAIVYPFIISSESY 3540
Query: 1984 TTARHNAANKILKNMCEHSNTL-----VQQAMMVSEELIRVAILWHEMWHEGLEEASRLY 2038
+ + +K + + + L +Q + ++L +L+ + ++ E ++
Sbjct: 3541 SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP 3600
Query: 2039 FGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGN----- 2093
++N++ M+E + + F Q +G+ E+ + + K G+
Sbjct: 3601 VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGK------EFDKHFGKGGSKLLRM 3654
Query: 2094 -VKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPN-QPI- 2150
+ D ++ + SK L K+ R+ EL +PG YD +P+
Sbjct: 3655 KLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRN-ELEIPGQYDGRGKPLP 3713
Query: 2151 ---IRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNT 2207
+RI + V+ S +RP+++ + G + E FL+KG EDLRQD+RV QLF ++N
Sbjct: 3714 EYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNG 3773
Query: 2208 LLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRI 2267
+LA D ++ L ++ Y+V+P++++ P C+ +D+ K ++ +H +
Sbjct: 3774 ILAQDSACSQRALQLRTYSVVPMTSSDPR---APPCE-----YKDWLTK----MSGKHDV 3821
Query: 2268 MLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVM 2327
M Y + V F + D L + S S E + R+++ S A++
Sbjct: 3822 GAYMLM-YKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALI 3880
Query: 2328 SMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTN-- 2385
+ +ILG+GDRH +N M+ +G ++ IDFG F A PE +PFRLTR N
Sbjct: 3881 CISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM 3940
Query: 2386 -AMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWR 2430
M+ TGL Y I H + R + ++ FV +P +W+
Sbjct: 3941 LPMKETGL--MYSIMVH-ALRAFRSDPGLLTNTMDVFVKEPSFDWK 3983
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 140 bits (352), Expect = 2e-32
Identities = 127/526 (24%), Positives = 239/526 (45%), Gaps = 48/526 (9%)
Query: 1924 VEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKST 1983
+ V Q +W I ++A +D + + + + +I +PQA++YP ++S+S
Sbjct: 3486 ISSVPCWQFISW---ISHMVALLDKDQAVA---VQHSVEEITDNYPQAIVYPFIISSESY 3539
Query: 1984 TTARHNAANKILKNMCEHSNTL-----VQQAMMVSEELIRVAILWHEMWHEGLEEASRLY 2038
+ + +K + + + L +Q + ++L +L+ + ++ E ++
Sbjct: 3540 SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP 3599
Query: 2039 FGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGN----- 2093
++N++ M+E + + F Q +G+ E+ + + K G+
Sbjct: 3600 VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGK------EFDKHFGKGGSKLLRM 3653
Query: 2094 -VKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPN-QPI- 2150
+ D ++ + SK L K+ R+ EL +PG YD +P+
Sbjct: 3654 KLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRN-ELEIPGQYDGRGKPLP 3712
Query: 2151 ---IRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNT 2207
+RI + V+ S +RP+++ + G + E FL+KG EDLRQD+RV QLF ++N
Sbjct: 3713 EYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNG 3772
Query: 2208 LLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRI 2267
+LA D ++ L ++ Y+V+P++++ P C+ +D+ K ++ +H +
Sbjct: 3773 ILAQDSACSQRALQLRTYSVVPMTSSDPR---APPCE-----YKDWLTK----MSGKHDV 3820
Query: 2268 MLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVM 2327
M Y + V F + D L + S S E + R+++ S A++
Sbjct: 3821 GAYMLM-YKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALI 3879
Query: 2328 SMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTN-- 2385
+ +ILG+GDRH +N M+ +G ++ IDFG F A PE +PFRLTR N
Sbjct: 3880 CISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM 3939
Query: 2386 -AMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWR 2430
M+ TGL Y I H + R + ++ FV +P +W+
Sbjct: 3940 LPMKETGL--MYSIMVH-ALRAFRSDPGLLTNTMDVFVKEPSFDWK 3982
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 73.2 bits (178), Expect = 3e-12
Identities = 126/626 (20%), Positives = 237/626 (37%), Gaps = 96/626 (15%)
Query: 1926 GVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYP---LTVASKS 1982
GV IQ WL IPQL+ + G+L+ L++ +GR +PQA+ +P L + K
Sbjct: 3196 GVPPIQ---WLAWIPQLLTCLVGSE---GKLLLNLISQVGRVYPQAVYFPIRTLYLTLKI 3249
Query: 1983 TTTARHNA-------------ANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHE---- 2025
R+ + ++I+ E TL+ + ++++ WHE
Sbjct: 3250 EQRERYKSDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLR 3309
Query: 2026 MWHEGLEEASRLYFGER-------------------------------NVKGMFEVLEPL 2054
+GL + + F + NV MF
Sbjct: 3310 QLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAAS- 3368
Query: 2055 HAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ 2114
++ R T ++ F + G+ + MK N+ + W + +KQ
Sbjct: 3369 ESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKW---IKILEAKTKQ 3425
Query: 2115 LPQLTSLELQYVSPKLLMCRDLELAVPGTY---DPNQPIIRIQSIAPSLQVITSKQRP-R 2170
LP+ +E + + E+ +PG + P I+I P ++++ R
Sbjct: 3426 LPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAAR 3485
Query: 2171 KLTLMGSNGHEFVFLLKGHEDL---RQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAV 2227
+L + G NG + +L+ L R++ERV+QL L+N L + +++L V
Sbjct: 3486 RLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRV 3545
Query: 2228 IPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKV--- 2284
+ +S L+ P +L + + KK IEH + YD L +Q
Sbjct: 3546 VAVSPQMRLVEDNPSSLSLVEIYKQRCAKK----GIEHDNPISRY--YDRLATVQARGTQ 3599
Query: 2285 -------EVFEHAVNNTAGDDLAKLLWLKS-PSSEVWFDRRTNYTRSLAVMSMVGYILGL 2336
++ + +N + K L + P++ ++ R +T LA++ ++L L
Sbjct: 3600 ASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHL 3659
Query: 2337 GDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNY 2396
+P L + + +GK+ F A +PFRLT ++ + G+ G
Sbjct: 3660 NRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPL 3719
Query: 2397 RITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDS-YSAGQSV 2455
+ V + V +L+ + D ++ W +K+++ T S SA
Sbjct: 3720 TASMIAVARCFAQPNFKVDGILKTVLRDEIIAW---------HKKTQEDTSSPLSAAGQP 3770
Query: 2456 EILDGVELGEPAHKKTGTTVPESIHS 2481
E +D +L K T + +H+
Sbjct: 3771 ENMDSQQLVSLVQKAV-TAIMTRLHN 3795
Score = 37.0 bits (84), Expect = 0.25
Identities = 54/272 (19%), Positives = 103/272 (37%), Gaps = 19/272 (6%)
Query: 1399 YKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWED 1458
+ E E P IL+SL + + LQ+ + AG+ + K+ A YE+ +E
Sbjct: 2713 FYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKY--SETATAIAYEQHGFFEQ 2770
Query: 1459 ALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCE---KWTLVNDETQAK---M 1512
A +Y+K MD K + E W +C + +W + + Q+K
Sbjct: 2771 AQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHIN 2830
Query: 1513 ARMAAAAAWGLGQWDSMEEYTCMI----PRD-THDGAFYRAVLAL---HQDLFSLAQQCI 1564
+ AW + W +M+E + P++ YR LA+ + S ++ +
Sbjct: 2831 PYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLV 2890
Query: 1565 DKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQ 1624
+ A L E + + + + EL+E Q + + R L
Sbjct: 2891 EMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRN---NSLH 2947
Query: 1625 GCQRIVEDWQKILMVRSLVVSPHEDMRTWLKY 1656
+ +V+ W+ L + S +S + W ++
Sbjct: 2948 DMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQH 2979
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 72.0 bits (175), Expect = 7e-12
Identities = 77/340 (22%), Positives = 138/340 (40%), Gaps = 55/340 (16%)
Query: 2146 PNQPIIRIQSIAPSLQVI-TSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGL 2204
P +P ++I+ I P + S P +L +G ++ + K +DLRQD+ ++Q+ L
Sbjct: 594 PLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISL 653
Query: 2205 VNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIE 2264
++ LL + L+ + Y V+ ST G + ++ +L+ E
Sbjct: 654 MDKLLRKENLDLK----LTPYKVLATSTKHGFMQFIQSVPVAE------------VLDTE 697
Query: 2265 HRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL 2324
I +K E+ N + + + Y +S
Sbjct: 698 GSIQ----------NFFRKYAPSENGPNGISAEVM------------------DTYVKSC 729
Query: 2325 AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT 2384
A ++ YILG+GDRH NL+L + +GK+ HIDFG + R+ P P +L + +
Sbjct: 730 AGYCVITYILGVGDRHLDNLLLTK-TGKLFHIDFG----YILGRDPKPLPPPMKLNKEMV 784
Query: 2385 NAMEVTGLD--GNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRS 2442
M T + +R C+T LR + + ++ + V + + L T +
Sbjct: 785 EGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQD 844
Query: 2443 RTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSF 2482
+ R D S ++V + + + E H V E IH F
Sbjct: 845 KFRLD-LSDEEAVHYMQSL-IDESVHALFAAVV-EQIHKF 881
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 63.5 bits (153), Expect = 2e-09
Identities = 74/261 (28%), Positives = 108/261 (41%), Gaps = 59/261 (22%)
Query: 2165 SKQRPRKLTLMGSN-----GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN 2219
SK +P L +M SN G + K +DLRQD +Q+ L++ L + LR
Sbjct: 754 SKMKP--LWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLR-- 809
Query: 2220 LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT 2279
+ Y +P +GLI V DT+ NI+
Sbjct: 810 --MTPYGCLPTGDRTGLIEVVLRSDTI--------------ANIQ--------------- 838
Query: 2280 LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN-YTRSLAVMSMVGYILGLGD 2338
+ K + A N A L WLKS + DR +T S A + Y+LG+GD
Sbjct: 839 -LNKSNMAATAAFNKD----ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD 893
Query: 2339 RHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTRMLTNAMEVTGLDGN 2395
RH N+M+ R SG++ HIDFG + + KF E++PF LT + ++ G N
Sbjct: 894 RHSDNIMI-RESGQLFHIDFGHF--LGNFKTKFGINRERVPFILTYDFVHVIQ-QGKTNN 949
Query: 2396 ------YRITCHTVMEVLREH 2410
+R C +LR H
Sbjct: 950 SEKFERFRGYCERAYTILRRH 970
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 59.3 bits (142), Expect = 5e-08
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 45/226 (19%)
Query: 2159 SLQVITSKQRPRKLTLMGSN--GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSL 2216
S +S P K+T++ ++ G E + K EDLRQD +Q+ +++ + + L
Sbjct: 1108 SCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDL 1167
Query: 2217 RKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYD 2276
R + + + + G++ VP DTL
Sbjct: 1168 RMVI----FKCLSTGRDRGMVELVPASDTL------------------------------ 1193
Query: 2277 HLTLMQKVEVFEHAVNNTAGDD-LAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILG 2335
+K++V E+ V + D LA+ L +PS E + N+ S A + Y+LG
Sbjct: 1194 -----RKIQV-EYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLG 1247
Query: 2336 LGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT 2380
+ DRH N+ML R +G + HIDFG A F ++ PF LT
Sbjct: 1248 ICDRHNDNIML-RSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLT 1292
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 58.2 bits (139), Expect = 1e-07
Identities = 69/288 (23%), Positives = 117/288 (40%), Gaps = 52/288 (18%)
Query: 2146 PNQPIIRIQSIA-PSLQVITSKQRPRKLTLMGSN--GHEFVFLLKGHEDLRQDERVMQLF 2202
P P + I+ I + TS P K+T + +N G + K +DLRQD V+QL
Sbjct: 877 PLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLI 936
Query: 2203 GLVNTLLANDPTSLRKNLSIQRYAVIPLST--NSGLIGWVPHCDTLHALIRDYREKKKIL 2260
+++ + L++ L +Q LST + GL+ VP TL + R ++
Sbjct: 937 QVMDNIW------LQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRH----SGLI 986
Query: 2261 LNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNY 2320
++ + + ++HL D K L N+
Sbjct: 987 GPLKENTIKKWFSQHNHLKA-----------------DYEKAL--------------RNF 1015
Query: 2321 TRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMT-----REKFPEKI 2375
S A +V +ILG+ DRH N+ML + SG + HIDFG A T R++ P
Sbjct: 1016 FYSCAGWCVVTFILGVCDRHNDNIMLTK-SGHMFHIDFGKFLGHAQTFGGIKRDRAPFIF 1074
Query: 2376 PFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVY 2423
+ +T + ++ C ++R+H ++ +LE +Y
Sbjct: 1075 TSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLY 1122
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 56.2 bits (134), Expect = 4e-07
Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 54/276 (19%)
Query: 2147 NQPIIRIQSIAPSLQVITSKQRPRKLTLMGSN---GHEFV-FLLKGHEDLRQDERVMQLF 2202
N +I + + + SK +P L L+ +N G + V + K +DLRQD +Q+
Sbjct: 763 NPCVILSELYVEKCKYMDSKMKP--LWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQML 820
Query: 2203 GLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN 2262
L++ L LR + Y + SGLI V +T+ I LN
Sbjct: 821 RLMDLLWKEAGLDLR----MLPYGCLATGDRSGLIEVVSTSETI----------ADIQLN 866
Query: 2263 IEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTR 2322
+ + A ++ L+ ++ + +GDDL + + +T
Sbjct: 867 SSN---VAAAAAFNKDALLNWLKEYN------SGDDLDRAI--------------EEFTL 903
Query: 2323 SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF---PEKIPFRL 2379
S A + Y+LG+GDRH N+M+ + +G++ HIDFG + + KF E++PF L
Sbjct: 904 SCAGYCVASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHI--LGNFKSKFGIKRERVPFIL 960
Query: 2380 TRMLTNAMEV-----TGLDGNYRITCHTVMEVLREH 2410
T + ++ T G +R C +LR H
Sbjct: 961 TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRH 996
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 55.1 bits (131), Expect = 9e-07
Identities = 69/277 (24%), Positives = 119/277 (42%), Gaps = 61/277 (22%)
Query: 2122 ELQYVSPKLLMCR----DLELAVPGTYDPNQPIIRIQSIA-PSLQVITSKQRPRKLTLMG 2176
E Q V K L+ + D A+ G P P ++ ++ ++++S +RP L
Sbjct: 726 ETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWEN 785
Query: 2177 SN--------GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVI 2228
+ +E +F K +DLRQD +Q+ ++ + N LR + Y +
Sbjct: 786 PDIMSELLFQNNEIIF--KNGDDLRQDMLTLQIIRIMENIWQNQGLDLR----MLPYGCL 839
Query: 2229 PLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFE 2288
+ GLI V + T+ + I+ + L+ A ++ TL Q
Sbjct: 840 SIGDCVGLIEVVRNSHTI--------------MQIQCKGGLKGALQFNSHTLHQ------ 879
Query: 2289 HAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN-YTRSLAVMSMVGYILGLGDRHPSNLMLD 2347
WLK + +D + +TRS A + +ILG+GDRH SN+M+
Sbjct: 880 ---------------WLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMV- 923
Query: 2348 RLSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTR 2381
+ G++ HIDFG + ++KF E++PF LT+
Sbjct: 924 KDDGQLFHIDFGHFLD--HKKKKFGYKRERVPFVLTQ 958
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 53.5 bits (127), Expect = 3e-06
Identities = 61/239 (25%), Positives = 107/239 (44%), Gaps = 52/239 (21%)
Query: 2185 LLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCD 2244
++K +DLRQ+ Q+ + ++ + R L I+ Y ++ +S +SG+I V +
Sbjct: 574 IVKCGDDLRQELLAFQVLKQLQSIWEQE----RVPLWIKPYKILVISADSGMIEPVVNAV 629
Query: 2245 TLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLW 2304
++H + KK+ L++ DY +Q EH
Sbjct: 630 SIHQV------KKQSQLSLL---------DY----FLQ-----EHG-------------- 651
Query: 2305 LKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEV 2364
S ++E + + N+ +S A +V Y+L + DRH N++LD G I+HIDFG
Sbjct: 652 --SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSS 708
Query: 2365 AMTREKFPEKIPFRLTRMLTNAMEVTGLDGN----YRITCHTVMEVLREHKDSVMAVLE 2419
+ F E F+LT + M GLDG+ Y++ + R+H D V+ ++E
Sbjct: 709 SPRNLGF-ETSAFKLTTEFVDVM--GGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 50.8 bits (120), Expect = 2e-05
Identities = 49/218 (22%), Positives = 86/218 (39%), Gaps = 45/218 (20%)
Query: 2146 PNQPIIRIQSIAP-SLQVITSKQRPRKLTLMGSN--GHEFVFLLKGHEDLRQDERVMQLF 2202
P P + ++ I P S P KL+ + G + K +DLRQD +Q+
Sbjct: 1039 PLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1098
Query: 2203 GLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN 2262
+++ + + +R + + G++ +P+ +TL
Sbjct: 1099 RIMSKIWVQEGLDMRMVI----FRCFSTGRGRGMVEMIPNAETL---------------- 1138
Query: 2263 IEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD-DLAKLLWLKSPSSEVWFDRRTNYT 2321
+K++V EH V + D LA L +P + + N+
Sbjct: 1139 -------------------RKIQV-EHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFI 1178
Query: 2322 RSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG 2359
S A + Y+LG+ DRH N+ML + +G + HIDFG
Sbjct: 1179 YSCAGCCVATYVLGICDRHNDNIML-KTTGHMFHIDFG 1215
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 50.1 bits (118), Expect = 3e-05
Identities = 86/388 (22%), Positives = 152/388 (39%), Gaps = 37/388 (9%)
Query: 419 HVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP---KDFAHKRQKA 475
H+L+ ++ +R L L +S+ P + + A LP + H Q A
Sbjct: 655 HILASFLRKNQRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLA 714
Query: 476 MQVDATVFTCI-SMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKD 534
+ ATV + L GP + + ++ L P+L G+ A L L P
Sbjct: 715 VDFLATVTQAQPASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDY 774
Query: 535 IQDGLLKMLSLVLMHKPLRH-PGMPKGLAHQLA---SPGLTTLPEASDVGSITLALRTLG 590
+ L+ +L+ + + + PG+ K + H LA + P+ + + L
Sbjct: 775 AK--LISLLTAPVYEQAVDGGPGLHKQVFHSLARCVAALSAACPQEAASTASRLVCDARS 832
Query: 591 SFEFEGHSLTQF-----VRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVS 645
G + F V A E K + +EA L +PS + + ++ +
Sbjct: 833 PHSSTGVKVLAFLSLAEVGQVAGPGHQRELKAVLLEA------LGSPSEDVRAAASYALG 886
Query: 646 QTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERF-----DAHLAQAENLQALFVAL 700
+ + D L LL + +P +Y +L SL E D+ AE++ AL
Sbjct: 887 RVGAGSLPDFLPFLLEQ--IEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQR 944
Query: 701 NDQVFE-IRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGH 759
+ E R + +G+L +NP+F++P LRK L + I +K
Sbjct: 945 CEGAEEGTRGVVAECIGKLVLVNPSFLLPRLRKQLAAGRPHTRSTVITAVK--------F 996
Query: 760 LVSNAPRLIRPYMEPILKALILKLKDPD 787
L+S+ P I P ++ + + L+DPD
Sbjct: 997 LISDQPHPIDPLLKSFIGEFMESLQDPD 1024
>gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 2105
Score = 49.7 bits (117), Expect = 4e-05
Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 29/307 (9%)
Query: 1389 KCRAYAKALHYKE--LEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQ 1446
+ +AY +A+ + E + +K L L + + +P+ AGV K L+ Q
Sbjct: 1405 RSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGV-SAIRKAEPSLKEQ 1463
Query: 1447 ATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVND 1506
+E L DA YD+ + D G ++ + LG+ + Q ++
Sbjct: 1464 ILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSE 1523
Query: 1507 ETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDK 1566
T ++ AAW L QWD +E Y DG + L Q L S ++ I
Sbjct: 1524 WTD-ELNTYRVEAAWKLSQWDLVENYLAA------DGKSTTWSVRLGQLLLSAKKRDITA 1576
Query: 1567 ARD---LLDAE----LTAMAGE--SYSRAYGAMVSCHMLSELEEVIQ--YKLVP-ERREI 1614
D L+ AE L+A + E SY R Y +V HML ELE I+ ++ P + +
Sbjct: 1577 FYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQE 1636
Query: 1615 IRQIWWERLQGCQRIVEDWQKILMVRSLVVS-----PHEDM--RTWLKYASLCGKSGRLA 1667
W RL+ Q + IL +R ++S + +M WL+ A + K+G
Sbjct: 1637 DSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQ 1696
Query: 1668 LAHKTLV 1674
A+ L+
Sbjct: 1697 TAYNALL 1703
Score = 43.9 bits (102), Expect = 0.002
Identities = 17/47 (36%), Positives = 34/47 (72%)
Query: 2160 LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVN 2206
++++ S Q+P+K++L GS+G ++ + K +DLR+D R+M+ L+N
Sbjct: 2058 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLIN 2104
Score = 41.2 bits (95), Expect = 0.013
Identities = 37/151 (24%), Positives = 63/151 (41%), Gaps = 24/151 (15%)
Query: 1893 SLSRGNNL--QDTLRVLTLWFDYG----HWPD---------------VNEALVEGVKAIQ 1931
SL GN Q R+LTLW DYG W +N+ + E +
Sbjct: 1833 SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLA 1892
Query: 1932 IDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAA 1991
+L QLI+RI V ++ +++ + +PQ ++ +T SKS+ R N
Sbjct: 1893 PYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRC 1952
Query: 1992 NKILKNMCEHSNTL---VQQAMMVSEELIRV 2019
+IL +L V A ++++L+ +
Sbjct: 1953 KEILNKAIHMKKSLEKFVGDATRLTDKLLEL 1983
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 48.1 bits (113), Expect = 1e-04
Identities = 23/47 (48%), Positives = 33/47 (70%), Gaps = 1/47 (2%)
Query: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE 2363
R N+ RS+A S++ ++L + DRH N+MLD+ G I+HIDFG FE
Sbjct: 688 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHIDFGFMFE 733
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 48.1 bits (113), Expect = 1e-04
Identities = 23/47 (48%), Positives = 33/47 (70%), Gaps = 1/47 (2%)
Query: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE 2363
R N+ RS+A S++ ++L + DRH N+MLD+ G I+HIDFG FE
Sbjct: 1878 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHIDFGFMFE 1923
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
3 alpha [Homo sapiens]
Length = 286
Score = 48.1 bits (113), Expect = 1e-04
Identities = 23/47 (48%), Positives = 33/47 (70%), Gaps = 1/47 (2%)
Query: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE 2363
R N+ RS+A S++ ++L + DRH N+MLD+ G I+HIDFG FE
Sbjct: 142 RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHIDFGFMFE 187
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 45.4 bits (106), Expect = 7e-04
Identities = 88/401 (21%), Positives = 157/401 (39%), Gaps = 46/401 (11%)
Query: 734 LIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPG 793
L+Q+L HS +E +L +V++ P +P+ +L+ L L + +PG
Sbjct: 119 LLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVG---SPG 175
Query: 794 VINNVLATIGELAQVSGLE----MRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVA 849
++ L T+ +A E R V +L + + ++ AK AL L +L+
Sbjct: 176 LLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDE--AKACEALEALDELLE 233
Query: 850 STGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA-IRVLGLLGALDPYKHKVNIG---- 904
S V+ PY L EVL L+ +N IR+L L L K K +
Sbjct: 234 SEVPVITPY-----LSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLL 288
Query: 905 --MIDQSRDASAVSLSESKSSQDSSDYSTSEMLVN-MGNLPLDEFYPAVSMVAL------ 955
++ A + + D E+ + MG P V M+AL
Sbjct: 289 PPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEK 348
Query: 956 ----MRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQ-VMPTFLNVIRVCDG---- 1006
+ +++L +A + L + Q ++P L + VC G
Sbjct: 349 LCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQI--VCKGLEDP 406
Query: 1007 --AIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFW----VMNTSIQSTIILLIEQIV 1060
+R LG ++ HI Y E++ L+ + + +T + +E V
Sbjct: 407 SQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFV 466
Query: 1061 VALGGEFKLYLPQLIPHMLRVFMHDNSP-GRIVSIKLLAAI 1100
LG + + YLP+L+ ML++ + +SP + +++ L AI
Sbjct: 467 ENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAI 507
Score = 36.2 bits (82), Expect = 0.42
Identities = 45/206 (21%), Positives = 82/206 (39%), Gaps = 21/206 (10%)
Query: 846 QLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLL--GALDPYKHKVNI 903
Q+V + P + P L+ +L L++E R+ + VL +L GA D + ++
Sbjct: 335 QVVDMLALHLPPEKLCPQLMPMLEEALRSESPY-QRKAGLLVLAVLSDGAGDHIRQRLLP 393
Query: 904 GMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNL-----PLDEFYPAVSMVALMRI 958
++ K +D S + L +G P Y M L+
Sbjct: 394 PLLQ----------IVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAY 443
Query: 959 FRDQSLSHHHTMV--VQAITFIFKSLGLKCVQFLPQVMPTFLNVIR-VCDGAIREFLFQQ 1015
+ L H H + A+ ++LG K +LP++M L ++R +E
Sbjct: 444 LKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSA 503
Query: 1016 LGMLVSFVKSHIRPYMDEIVTLMREF 1041
LG + + ++ + PY I+ +REF
Sbjct: 504 LGAIATAAQASLLPYFPAIMEHLREF 529
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 44.7 bits (104), Expect = 0.001
Identities = 58/259 (22%), Positives = 104/259 (40%), Gaps = 58/259 (22%)
Query: 2146 PNQPIIRIQSIA-PSLQVITSKQRPRKLTLMGSN----GHEFVFLLKGH-EDLRQDERVM 2199
P P ++ ++A +V+ SK++P L ++ +E + ++ H +DLRQD ++
Sbjct: 786 PYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLIL 845
Query: 2200 QLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKI 2259
Q+ ++ ++ + +L + Y I G+I V T+
Sbjct: 846 QILRIMESIWETESL----DLCLLPYGCISTGDKIGMIEIVKDATTI------------- 888
Query: 2260 LLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNT-AGDDLAKLLWLK--SPSSEVWFDR 2316
++ + V NT A D WLK SP+ E +
Sbjct: 889 ------------------------AKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAA 924
Query: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF----P 2372
+ S A + ++LG+GDRH N+M+ +G + HIDFG + + F
Sbjct: 925 VERFVYSCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG---HILGNYKSFLGINK 980
Query: 2373 EKIPFRLTRMLTNAMEVTG 2391
E++PF LT M +G
Sbjct: 981 ERVPFVLTPDFLFVMGTSG 999
>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
Length = 1119
Score = 43.5 bits (101), Expect = 0.003
Identities = 85/381 (22%), Positives = 149/381 (39%), Gaps = 41/381 (10%)
Query: 419 HVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP---KDFAHKRQKA 475
H+L+ ++ +R L L +S+ P + + A LP + H Q A
Sbjct: 562 HILASFLRKNQRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLA 621
Query: 476 MQVDATVFTCI-SMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKD 534
+ ATV + L GP + + ++ L P+L G+ A L L P
Sbjct: 622 VDFLATVTQAQPASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDY 681
Query: 535 IQDGLLKMLSLVLMHKPLRH-PGMPKGLAHQLA---SPGLTTLPEASDVGSITLALRTLG 590
+ L+ +L+ + + + PG+ K + H LA + P+ + + L
Sbjct: 682 AK--LISLLTAPVYEQAVDGGPGLHKQVFHSLARCVAALSAACPQEAASTASRLVCDARS 739
Query: 591 SFEFEGHSLTQF-----VRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVS 645
G + F V A E K + +EA L +PS + + ++ +
Sbjct: 740 PHSSTGVKVLAFLSLAEVGQVAGPGHQRELKAVLLEA------LGSPSEDVRAAASYALG 793
Query: 646 QTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERF-----DAHLAQAENLQALFVAL 700
+ + D L LL + +P +Y +L SL E D+ AE++ AL
Sbjct: 794 RVGAGSLPDFLPFLLEQ--IEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQR 851
Query: 701 NDQVFE-IRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGH 759
+ E R + +G+L +NP+F++P LRK L + I +K
Sbjct: 852 CEGAEEGTRGVVAECIGKLVLVNPSFLLPRLRKQLAAGRPHTRSTVITAVK--------F 903
Query: 760 LVSNAPRLIRPYMEPILKALI 780
L+S+ P I +P+LK+ I
Sbjct: 904 LISDQPHPI----DPLLKSFI 920
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 39.7 bits (91), Expect = 0.038
Identities = 69/266 (25%), Positives = 105/266 (39%), Gaps = 46/266 (17%)
Query: 556 GMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGH---SLTQFVRHCADHFLN 612
GMPK L LA P LT L D G+I + LR+ S + EG +L Q V +
Sbjct: 714 GMPKPLQKVLADPRLTALQR--DGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVR 771
Query: 613 SEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIR 672
+ ++ + R C R L + +SG + + D LS L + ++R
Sbjct: 772 LSNLHVQQQEQRQCLRRLQQVLQWLSGPGE-EQLASFAMPGDTLSAL-------QETELR 823
Query: 673 Y-CVLASLDERFDAHLAQAENLQALFV-ALNDQVFEIRELAICTVGRLSSMNPAFVMPFL 730
+ A + ER LAQA AL A + +V +I E RL +
Sbjct: 824 FRAFSAEVQER----LAQAREALALEENATSQKVLDIFE------QRLEQVESG----LH 869
Query: 731 RKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDP 790
R + +Q + H + E AR+ G P E +L AL L+ P+P
Sbjct: 870 RALRLQRFFQQAHEW---VDEGFARLAG---------AGPGREAVLAALALRRA---PEP 914
Query: 791 NPGVINNVLATIGELAQVSGLEMRKW 816
+ G + A +L + L R+W
Sbjct: 915 SAGTFQEMRALALDLGSPAAL--REW 938
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 38.9 bits (89), Expect = 0.066
Identities = 32/163 (19%), Positives = 72/163 (44%), Gaps = 6/163 (3%)
Query: 944 DEFYPAVSMVA--LMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVI 1001
D P+V + L+RI D+ + +++ ++ + +G+ FLPQ+ TF +
Sbjct: 2297 DALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKAL 2356
Query: 1002 RVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVV 1061
+ + +R LG L+S + + P E++ +R + + ++ T++ + ++
Sbjct: 2357 QDSNRGVRLKAADALGKLIS-IHIKVDPLFTELLNGIRA--MEDPGVRDTMLQALRFVIQ 2413
Query: 1062 ALGGEFKLYL-PQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLF 1103
G + + ++ +L + HD RI S L + F
Sbjct: 2414 GAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAF 2456
Score = 32.7 bits (73), Expect = 4.7
Identities = 50/248 (20%), Positives = 93/248 (37%), Gaps = 47/248 (18%)
Query: 652 VADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHL--AQAENLQALFV--ALNDQVFEI 707
V D L + V+ + PD C LA + +L +Q + L FV ALND+ ++
Sbjct: 1215 VLDALGR--VISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFFVPDALNDRHPDV 1272
Query: 708 R----ELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSN 763
R + A+ T+ N ++P + L + + + ++ ++G L +
Sbjct: 1273 RKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAV---RQSVVVLMGSLAKH 1329
Query: 764 APRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSG----------LEM 813
+ P ++PI+ LI L P V + + + + + +G LE
Sbjct: 1330 LDKS-DPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQRLMQQLLES 1388
Query: 814 RKWVD-----------------------ELFIIIMDMLQDSSLLAKRQVALWTLGQLVAS 850
K+ + E+ + D +QD +R+ AL+ L
Sbjct: 1389 DKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTM 1448
Query: 851 TGYVVEPY 858
G + EPY
Sbjct: 1449 LGKLFEPY 1456
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 38.5 bits (88), Expect = 0.086
Identities = 35/133 (26%), Positives = 69/133 (51%), Gaps = 17/133 (12%)
Query: 950 VSMVALMRIFRDQSLSHH-HTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNV-------I 1001
V M +L+R+F+ + S + A++ + + LG + ++++ P FL +
Sbjct: 606 VVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKP-FLGIGLKNYAEY 664
Query: 1002 RVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWV---MNTSIQSTIILLIEQ 1058
+VC A+ +G L ++S+I P+ DE++ L+ E ++ S++ I+ +
Sbjct: 665 QVCLAAVG-----LVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Query: 1059 IVVALGGEFKLYL 1071
I +A+GGEFK YL
Sbjct: 720 IALAIGGEFKKYL 732
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,255,648
Number of Sequences: 37866
Number of extensions: 3845308
Number of successful extensions: 13072
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 11976
Number of HSP's gapped (non-prelim): 1074
length of query: 2549
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2430
effective length of database: 13,741,464
effective search space: 33391757520
effective search space used: 33391757520
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.