Guide to the Human Genome
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Name: PIK3CA Sequence: fasta or formatted (1068aa) NCBI GI: 54792082
Description:

phosphoinositide-3-kinase, catalytic, alpha polypeptide

Referenced in:

Inositol Pathways

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             4.2         45           2
 C cysteine            3.0         32           1
 D aspartate           5.4         58           2
 E glutamate           7.1         76           2
 F phenylalanine       4.1         44           3
 G glycine             4.6         49           2
 H histidine           2.8         30           2
 I isoleucine          6.6         71           2
 K lysine              6.7         72           4
 L leucine            11.8        126           3
 M methionine          3.7         39           2
 N asparagine          5.2         56           2
 P proline             4.8         51           2
 Q glutamine           4.5         48           1
 R arginine            5.5         59           2
 S serine              5.4         58           2
 T threonine           3.7         40           2
 V valine              5.2         56           2
 W tryptophan          1.8         19           1
 Y tyrosine            3.7         39           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   phosphoinositide-3-kinase, catalytic, alpha polypept... 
PIK3CD                0.330   catalytic phosphatidylinositol 3-kinase delta [Homo...
PIK3CB                0.327   catalytic phosphatidylinositol 3-kinase beta 
PIK3CG                0.236   phosphoinositide-3-kinase, catalytic, gamma polypept...
PIK3C2B               0.165   phosphoinositide-3-kinase, class 2 beta polypeptide...
PIK3C2A               0.161   phosphoinositide-3-kinase, class 2 alpha polypeptid...
PIK3C2G               0.132   phosphoinositide-3-kinase, class 2 gamma polypeptid...
PIK3C3                0.064   catalytic phosphatidylinositol 3-kinase 3 
PI4KA                 0.059   phosphatidylinositol 4-kinase type 3 alpha isoform 1 ...
PI4KA                 0.059   phosphatidylinositol 4-kinase type 3 alpha isoform ...
PI4KB                 0.041   catalytic phosphatidylinositol 4-kinase beta 
LOC100293141          0.027   PREDICTED: similar to phosphatidylinositol 4-kinase...
MTOR                  0.014   FK506 binding protein 12-rapamycin associated protein...
PRKDC                 0.010   protein kinase, DNA-activated, catalytic polypeptid...
LOC731751             0.010   PREDICTED: similar to protein kinase, DNA-activated...
ATM                   0.009   ataxia telangiectasia mutated isoform 2 
ATM                   0.009   ataxia telangiectasia mutated isoform 1 
LOC651610             0.009   PREDICTED: similar to Serine-protein kinase ATM, pa...
PRKDC                 0.009   protein kinase, DNA-activated, catalytic polypeptide...
ATR                   0.008   ataxia telangiectasia and Rad3 related protein [Hom...
LOC648152             0.008   PREDICTED: similar to ataxia telangiectasia and Rad...
SMG1                  0.007   PI-3-kinase-related kinase SMG-1 
LARP4                 0.004   c-Mpl binding protein isoform a 
LARP4                 0.004   c-Mpl binding protein isoform c 
AP4B1                 0.003   adaptor-related protein complex 4, beta 1 subunit [...
WASF3                 0.003   WAS protein family, member 3 
FBXO46                0.003   F-box protein 46 
KIN                   0.003   HsKin17 protein 
ARMCX2                0.003   ALEX2 protein 
ARMCX2                0.003   ALEX2 protein 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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