Search of human proteins with 4759306

Search of human proteins with 4759306

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4759306 lin-7 homolog A [Homo sapiens]
         (233 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4759306 lin-7 homolog A [Homo sapiens]                             455   e-128
gi|8922944 lin-7 homolog C [Homo sapiens]                             318   3e-87
gi|11545920 lin-7 homolog B [Homo sapiens]                            315   3e-86
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      87   2e-17
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      87   2e-17
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       87   2e-17
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    82   3e-16
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    82   3e-16
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    80   2e-15
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    80   2e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           78   7e-15
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           78   7e-15
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    74   8e-14
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    74   8e-14
gi|148746189 multiple PDZ domain protein [Homo sapiens]                71   9e-13
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    67   1e-11
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    67   1e-11
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    67   1e-11
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    67   1e-11
gi|7706025 PDZ domain containing 11 [Homo sapiens]                     67   1e-11
gi|31742501 sorting nexin family member 27 [Homo sapiens]              67   2e-11
gi|112382257 InaD-like [Homo sapiens]                                  66   3e-11
gi|45827729 scribble isoform b [Homo sapiens]                          65   4e-11
gi|45827731 scribble isoform a [Homo sapiens]                          65   4e-11
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                      65   4e-11
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    65   6e-11
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    65   6e-11
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    65   6e-11
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]    64   8e-11
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                          64   8e-11

>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score =  455 bits (1170), Expect = e-128
 Identities = 233/233 (100%), Positives = 233/233 (100%)

Query: 1   MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE 60
           MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE
Sbjct: 1   MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE 60

Query: 61  FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF 120
           FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF
Sbjct: 61  FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF 120

Query: 121 NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD 180
           NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD
Sbjct: 121 NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD 180

Query: 181 SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS 233
           SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
Sbjct: 181 SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS 233


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score =  318 bits (814), Expect = 3e-87
 Identities = 154/191 (80%), Positives = 178/191 (93%)

Query: 21  QPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNG 80
           +P+ L+RD+ RAIELLEKLQ SGEVP  KLQ+L++VLQSEFC A+REVY++++ET+ ++ 
Sbjct: 6   EPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISS 65

Query: 81  CPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPG 140
            PE RA ATAKATVAAFAASEGHSHPRVVELPKT+EGLGFN+MGGKEQNSPIYISRIIPG
Sbjct: 66  SPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPG 125

Query: 141 GVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARF 200
           G+A+RHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAA+  VKLVVRYTPKVLEEME+RF
Sbjct: 126 GIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRF 185

Query: 201 EKLRTARRRQQ 211
           EK+R+A+RRQQ
Sbjct: 186 EKMRSAKRRQQ 196


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score =  315 bits (806), Expect = 3e-86
 Identities = 154/195 (78%), Positives = 179/195 (91%)

Query: 19  VVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITV 78
           +V+PL L+RDV+RA+ELLE+LQ SGE+P  KLQ+L++VLQS FC+AIREVY+ +++T+ +
Sbjct: 4   LVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDI 63

Query: 79  NGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRII 138
            G  E RA ATAKATVAAF ASEGH+HPRVVELPKTDEGLGFN+MGGKEQNSPIYISR+I
Sbjct: 64  TGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVI 123

Query: 139 PGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEA 198
           PGGVA+RHGGLKRGDQLLSVNGVSVEGE HEKAVELLKAA+ SVKLVVRYTP+VLEEMEA
Sbjct: 124 PGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEA 183

Query: 199 RFEKLRTARRRQQQQ 213
           RFEK+R+ARRRQQ Q
Sbjct: 184 RFEKMRSARRRQQHQ 198


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 47/117 (40%), Positives = 67/117 (57%), Gaps = 1/117 (0%)

Query: 88  ATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHG 147
           AT + ++    A      PR V L K   GLGFN++GG E    I++S I+ GG A+  G
Sbjct: 298 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSG 356

Query: 148 GLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
            L+RGDQ+LSVNG+ + G  HE+A   LK A  +V ++ +Y P+     EA+   LR
Sbjct: 357 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR 413



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           + L + + GLGF++ GG +      +  I+I++IIPGG A   G L+  D +L VN V V
Sbjct: 48  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKVLE 194
               H KAVE LK A   V+L VR    +LE
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 138



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 36/83 (43%), Positives = 53/83 (63%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A++ G L+ GD+LL VN  S+
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE+AV +LK   + V L V
Sbjct: 203 EEVTHEEAVAILKNTSEVVYLKV 225


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 47/117 (40%), Positives = 67/117 (57%), Gaps = 1/117 (0%)

Query: 88  ATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHG 147
           AT + ++    A      PR V L K   GLGFN++GG E    I++S I+ GG A+  G
Sbjct: 506 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSG 564

Query: 148 GLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
            L+RGDQ+LSVNG+ + G  HE+A   LK A  +V ++ +Y P+     EA+   LR
Sbjct: 565 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR 621



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           + L + + GLGF++ GG +      +  I+I++IIPGG A   G L+  D +L VN V V
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263

Query: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKVLE 194
               H KAVE LK A   V+L VR    +LE
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 294



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 36/83 (43%), Positives = 53/83 (63%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A++ G L+ GD+LL VN  S+
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE+AV +LK   + V L V
Sbjct: 359 EEVTHEEAVAILKNTSEVVYLKV 381


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 47/117 (40%), Positives = 67/117 (57%), Gaps = 1/117 (0%)

Query: 88  ATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHG 147
           AT + ++    A      PR V L K   GLGFN++GG E    I++S I+ GG A+  G
Sbjct: 401 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSG 459

Query: 148 GLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
            L+RGDQ+LSVNG+ + G  HE+A   LK A  +V ++ +Y P+     EA+   LR
Sbjct: 460 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR 516



 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           + L + + GLGF++ GG +      +  I+I++IIPGG A   G L+  D +L VN V V
Sbjct: 99  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158

Query: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKVLE 194
               H KAVE LK A   V+L VR    +LE
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 189



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 36/83 (43%), Positives = 53/83 (63%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A++ G L+ GD+LL VN  S+
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE+AV +LK   + V L V
Sbjct: 254 EEVTHEEAVAILKNTSEVVYLKV 276


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 82.4 bits (202), Expect = 3e-16
 Identities = 43/99 (43%), Positives = 61/99 (61%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR + L K   GLGFN++GG E    I++S I+ GG A+  G L+RGD++LSVNGV++  
Sbjct: 47  PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  SV +V +Y P+     E++   LR
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLR 144


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 82.4 bits (202), Expect = 3e-16
 Identities = 43/99 (43%), Positives = 61/99 (61%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR + L K   GLGFN++GG E    I++S I+ GG A+  G L+RGD++LSVNGV++  
Sbjct: 384 PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 442

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  SV +V +Y P+     E++   LR
Sbjct: 443 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLR 481



 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 37/83 (44%), Positives = 52/83 (62%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGG-KEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           V L K  +GLGF++ GG   Q+ P    IYI++II GG A++ G L+ GD+LL+VN  ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           +   HE+AV  LK   D V L V
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKV 309



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 100 SEGHSHPRVVELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQ 154
           S+G      + L + + GLGF++ GG +      +  I+I++IIPGG A   G L   D 
Sbjct: 123 SDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDC 182

Query: 155 LLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVR 187
           +L VN V V    H +AVE LK A   V+LVVR
Sbjct: 183 VLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR + + +   GLGFN++GG E    I+IS I+ GG A+  G L++GDQ+LSVNGV +  
Sbjct: 354 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  +V ++ +Y P+     EA+   LR
Sbjct: 413 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 451



 Score = 62.8 bits (151), Expect = 2e-10
 Identities = 40/109 (36%), Positives = 58/109 (53%), Gaps = 6/109 (5%)

Query: 100 SEGHSHPRVVELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQ 154
           +EG      + L + + GLGF++ GG +      +  I+I++IIPGG A + G L+  D 
Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159

Query: 155 LLSVNGVSVEGEHHEKAVELLKAAKDSVKL-VVRYTPKVLEEMEARFEK 202
           +L VN V V    H  AVE LK A   V+L V+R  P   + ME +  K
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 208



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 36/83 (43%), Positives = 51/83 (61%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A + G L+ GD++L+VN V +
Sbjct: 204 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 263

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE AV  LK   D V L V
Sbjct: 264 EDVMHEDAVAALKNTYDVVYLKV 286


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR + + +   GLGFN++GG E    I+IS I+ GG A+  G L++GDQ+LSVNGV +  
Sbjct: 308 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  +V ++ +Y P+     EA+   LR
Sbjct: 367 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 405



 Score = 62.8 bits (151), Expect = 2e-10
 Identities = 40/109 (36%), Positives = 58/109 (53%), Gaps = 6/109 (5%)

Query: 100 SEGHSHPRVVELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQ 154
           +EG      + L + + GLGF++ GG +      +  I+I++IIPGG A + G L+  D 
Sbjct: 54  TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 113

Query: 155 LLSVNGVSVEGEHHEKAVELLKAAKDSVKL-VVRYTPKVLEEMEARFEK 202
           +L VN V V    H  AVE LK A   V+L V+R  P   + ME +  K
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 162



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 36/83 (43%), Positives = 51/83 (61%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A + G L+ GD++L+VN V +
Sbjct: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE AV  LK   D V L V
Sbjct: 218 EDVMHEDAVAALKNTYDVVYLKV 240


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 77.8 bits (190), Expect = 7e-15
 Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR V L +   GLGFN++GG E    I+IS I+ GG A+  G L++GD+++SVN V +  
Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  +V +V +Y P+     EA+   LR
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLR 561



 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 37/83 (44%), Positives = 52/83 (62%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A + G L+ GD+LL+VN V +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE+AV  LK   D V L V
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKV 402



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 5/93 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           + L + + GLGF++ GG +      +S I+I++II GG A + G L+  D +L VN V V
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEM 196
               H KAVE LK A   V+L V+    V E++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI 317


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 77.8 bits (190), Expect = 7e-15
 Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%)

Query: 106 PRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           PR V L +   GLGFN++GG E    I+IS I+ GG A+  G L++GD+++SVN V +  
Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522

Query: 166 EHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLR 204
             HE+A   LK A  +V +V +Y P+     EA+   LR
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLR 561



 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 37/83 (44%), Positives = 52/83 (62%), Gaps = 5/83 (6%)

Query: 109 VELPKTDEGLGFNVMGGK-EQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           ++L K  +GLGF++ GG   Q+ P    IY+++II GG A + G L+ GD+LL+VN V +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379

Query: 164 EGEHHEKAVELLKAAKDSVKLVV 186
           E   HE+AV  LK   D V L V
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKV 402



 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 5/93 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQ-----NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
           + L + + GLGF++ GG +      +S I+I++II GG A + G L+  D +L VN V V
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 164 EGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEM 196
               H KAVE LK A   V+L V+    V E++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI 317


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 74.3 bits (181), Expect = 8e-14
 Identities = 57/186 (30%), Positives = 91/186 (48%), Gaps = 22/186 (11%)

Query: 25  LDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEF 84
           LD+++A  ++ ++ L    + P H    L   L++E       ++ + H+T+ +  C   
Sbjct: 210 LDKELAGRVQQIQLLGRDMKGPAH--DKLWNQLEAE-------IHLHRHKTV-IRAC--- 256

Query: 85  RARATAKATVAA--------FAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYIS 135
           R R   K  + A           S+G    R V L K D EGLG ++ GGKE   PI IS
Sbjct: 257 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS 316

Query: 136 RIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEE 195
            I PG  A+R GGL  GD +L+VNGV++    H++AV +L   +  ++  V Y    ++ 
Sbjct: 317 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS 376

Query: 196 MEARFE 201
            +   E
Sbjct: 377 DDENVE 382


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 74.3 bits (181), Expect = 8e-14
 Identities = 57/186 (30%), Positives = 91/186 (48%), Gaps = 22/186 (11%)

Query: 25  LDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEF 84
           LD+++A  ++ ++ L    + P H    L   L++E       ++ + H+T+ +  C   
Sbjct: 202 LDKELAGRVQQIQLLGRDMKGPAH--DKLWNQLEAE-------IHLHRHKTV-IRAC--- 248

Query: 85  RARATAKATVAA--------FAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYIS 135
           R R   K  + A           S+G    R V L K D EGLG ++ GGKE   PI IS
Sbjct: 249 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS 308

Query: 136 RIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEE 195
            I PG  A+R GGL  GD +L+VNGV++    H++AV +L   +  ++  V Y    ++ 
Sbjct: 309 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS 368

Query: 196 MEARFE 201
            +   E
Sbjct: 369 DDENVE 374


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 70.9 bits (172), Expect = 9e-13
 Identities = 38/101 (37%), Positives = 58/101 (57%), Gaps = 3/101 (2%)

Query: 89   TAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGG---KEQNSPIYISRIIPGGVAER 145
            T   + + F    G    + + L +  +GLGF+++GG      + PIY+  +   G A  
Sbjct: 1939 TGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998

Query: 146  HGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVV 186
             G LKRGDQ+++VNG S+EG  HE+AV +LK  K +V L+V
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 31/98 (31%), Positives = 54/98 (55%), Gaps = 2/98 (2%)

Query: 89  TAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGG 148
           +A +T++A +      H   +EL     GLGF ++GGK     + +  I+PGGVA++HG 
Sbjct: 238 SAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATG--VIVKTILPGGVADQHGR 295

Query: 149 LKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVV 186
           L  GD +L +    + G   E+  ++L+   + VKL++
Sbjct: 296 LCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 5/118 (4%)

Query: 74  ETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEG-LGFNVMGGKEQNSP- 131
           E +T  G P    +                 H  V EL K   G LGF+V+G + +N   
Sbjct: 103 EALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGE 162

Query: 132 --IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE-HHEKAVELLKAAKDSVKLVV 186
             I++  I  G VA R G LK  DQ+L++NG +++    H++A+ +L+ AKD+V+LV+
Sbjct: 163 LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVI 220



 Score = 58.5 bits (140), Expect = 5e-09
 Identities = 31/74 (41%), Positives = 47/74 (63%), Gaps = 4/74 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
           +EL K  +GLGF+++  ++   P    I I  ++PGG+AE+ G L  GD+L+ VN V++E
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760

Query: 165 GEHHEKAVELLKAA 178
               E+AVE LK A
Sbjct: 761 NSSLEEAVEALKGA 774



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 27/79 (34%), Positives = 46/79 (58%), Gaps = 1/79 (1%)

Query: 108  VVELPKTDEGLGFNVMGGKEQNS-PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++EL K   GLG ++ G K+++   ++I  I P G A + G L+  D+LL +NG  + G 
Sbjct: 1350 MIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409

Query: 167  HHEKAVELLKAAKDSVKLV 185
             H+ A  ++K A   VK++
Sbjct: 1410 SHQNASSIIKCAPSKVKII 1428



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 26/70 (37%), Positives = 43/70 (61%), Gaps = 1/70 (1%)

Query: 113  KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
            K  +GLG +++G K  ++ +++S I+ GG+A+  G L +GDQ+L VNG  V     E   
Sbjct: 1731 KPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVA 1789

Query: 173  ELLKAAKDSV 182
             LLK ++ S+
Sbjct: 1790 ALLKVSEGSL 1799



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 34/116 (29%), Positives = 61/116 (52%), Gaps = 8/116 (6%)

Query: 79   NGCPEFRA-RATAKATVAAFAASEGHSHPRV------VELPKTDEGLGFNVMGGKEQN-S 130
            +G PE  + R T++++  A  AS+  + P +      +E+ K   GLG +++GG +    
Sbjct: 1593 SGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG 1652

Query: 131  PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVV 186
             I I  +   G A + G L  GDQ+L VNG+ +    H++A+ +L+     V+L +
Sbjct: 1653 AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL 1708



 Score = 52.0 bits (123), Expect = 4e-07
 Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 1/125 (0%)

Query: 109  VELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHH 168
            +ELPK   GLG  +   ++  S + I  +   GVA   G LK GDQ+L+V+   V G   
Sbjct: 1484 LELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542

Query: 169  EKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQ 228
            EK + LLK AK +VKL +       + + +        ++   Q L++ Q    + +  +
Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602

Query: 229  QNHMS 233
                S
Sbjct: 1603 NTSRS 1607



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 31/84 (36%), Positives = 50/84 (59%), Gaps = 4/84 (4%)

Query: 107  RVVELPK-TDEGLGFNVMGGKEQ---NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
            R VE+ K   + LG ++ GG      + PI+I+ + P GVA +   L+ GD+++++ G S
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891

Query: 163  VEGEHHEKAVELLKAAKDSVKLVV 186
             EG  H +AV LLK A  S+++ V
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 39/154 (25%), Positives = 75/154 (48%), Gaps = 9/154 (5%)

Query: 76  ITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMG----GKEQNSP 131
           IT++  P     +T +  V A       S    VEL K  +GLG  + G     K + S 
Sbjct: 349 ITLSSSPT----STPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSG 404

Query: 132 IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKL-VVRYTP 190
           I++  I      E  G ++ GDQ+++V+G +++G  +++AVE+L+    +V L ++R   
Sbjct: 405 IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGM 464

Query: 191 KVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQ 224
           K   E+ +R +  + A        +I++  ++ +
Sbjct: 465 KQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 10/94 (10%)

Query: 104  SHPRVVEL-PKTDEGLGFNVMGGKEQNSP---------IYISRIIPGGVAERHGGLKRGD 153
            + PR VEL  +  + LG +++GG+   S          I+I  ++    A ++G LK GD
Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206

Query: 154  QLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVR 187
            +++ V+G+ +    HE+AVE ++ A + V  +V+
Sbjct: 1207 RIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 20/53 (37%), Positives = 31/53 (58%)

Query: 133 YISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLV 185
           +I  ++P G     G L  GD+LL VNG+++ GE+H+  V +LK     V +V
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629



 Score = 33.1 bits (74), Expect = 0.21
 Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 1/73 (1%)

Query: 104  SHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
            S  R + + K +  LG  V   K+    I +  II GG   R G +  GD +LS+N  S 
Sbjct: 1004 SFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEEST 1062

Query: 164  EGEHHEKAVELLK 176
                + +A  +L+
Sbjct: 1063 ISVTNAQARAMLR 1075


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 34/73 (46%), Positives = 49/73 (67%), Gaps = 3/73 (4%)

Query: 117  GLGFNVMGGKEQNS---PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVE 173
            GLGF ++GG++       I+IS + PGG A+  G LK GD+L+SVN VS+EG  H  A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 174  LLKAAKDSVKLVV 186
            +L+ A + V LV+
Sbjct: 1163 ILQNAPEDVTLVI 1175



 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 35/86 (40%), Positives = 51/86 (59%), Gaps = 8/86 (9%)

Query: 109  VELPKTDEGLGFNVM-----GGKE---QNSPIYISRIIPGGVAERHGGLKRGDQLLSVNG 160
            VEL K D  LG +V      GG     ++  IY+  +IP G AE  G + +GD++L+VNG
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428

Query: 161  VSVEGEHHEKAVELLKAAKDSVKLVV 186
            VS+EG  H++AVE L+     V L++
Sbjct: 1429 VSLEGATHKQAVETLRNTGQVVHLLL 1454



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 3/80 (3%)

Query: 108  VVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++ L K+++G LGF V  G  Q    Y+  +I    A+  G LK GD+L+ VN   V   
Sbjct: 1793 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1850

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H  AV LL+AA  +V+LV+
Sbjct: 1851 THTDAVNLLRAASKTVRLVI 1870



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)

Query: 109  VELPKTDEGLGF------NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
            V+L K   GLGF      N++  +   S + + ++ PG  A   G +  GD +L VNG S
Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566

Query: 163  VEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEEME 197
            ++G   ++ +  L+     V L++ R  P VL E++
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1602



 Score = 37.4 bits (85), Expect = 0.011
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 10/87 (11%)

Query: 109  VELPKTDEGLGFNVMGGKEQ-NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG-- 165
            + L    E LGF++ GG +     +YIS I P  VA   G L+  D +  VNGVS +G  
Sbjct: 1889 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1948

Query: 166  -EHHEKAVEL------LKAAKDSVKLV 185
             E   +A+++      LKA ++ + +V
Sbjct: 1949 LEEVNRALDMSLPSLVLKATRNDLPVV 1975


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
           isoform 3 [Homo sapiens]
          Length = 2294

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 34/73 (46%), Positives = 49/73 (67%), Gaps = 3/73 (4%)

Query: 117 GLGFNVMGGKEQNS---PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVE 173
           GLGF ++GG++       I+IS + PGG A+  G LK GD+L+SVN VS+EG  H  A+E
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971

Query: 174 LLKAAKDSVKLVV 186
           +L+ A + V LV+
Sbjct: 972 ILQNAPEDVTLVI 984



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 3/81 (3%)

Query: 109  VELPKTDEGLGFNVMGGKE---QNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
            VEL K D  LG +V GG     ++  IY+  +IP G AE  G + +GD++L+VNGVS+EG
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 166  EHHEKAVELLKAAKDSVKLVV 186
              H++AVE L+     V L++
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLL 1258



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 3/80 (3%)

Query: 108  VVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++ L K+++G LGF V  G  Q    Y+  +I    A+  G LK GD+L+ VN   V   
Sbjct: 1597 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1654

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H  AV LL+AA  +V+LV+
Sbjct: 1655 THTDAVNLLRAASKTVRLVI 1674



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)

Query: 109  VELPKTDEGLGF------NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
            V+L K   GLGF      N++  +   S + + ++ PG  A   G +  GD +L VNG S
Sbjct: 1311 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370

Query: 163  VEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEEME 197
            ++G   ++ +  L+     V L++ R  P VL E++
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1406



 Score = 37.4 bits (85), Expect = 0.011
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 10/87 (11%)

Query: 109  VELPKTDEGLGFNVMGGKEQ-NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG-- 165
            + L    E LGF++ GG +     +YIS I P  VA   G L+  D +  VNGVS +G  
Sbjct: 1693 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1752

Query: 166  -EHHEKAVEL------LKAAKDSVKLV 185
             E   +A+++      LKA ++ + +V
Sbjct: 1753 LEEVNRALDMSLPSLVLKATRNDLPVV 1779


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 34/73 (46%), Positives = 49/73 (67%), Gaps = 3/73 (4%)

Query: 117  GLGFNVMGGKEQNS---PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVE 173
            GLGF ++GG++       I+IS + PGG A+  G LK GD+L+SVN VS+EG  H  A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 174  LLKAAKDSVKLVV 186
            +L+ A + V LV+
Sbjct: 1163 ILQNAPEDVTLVI 1175



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 3/81 (3%)

Query: 109  VELPKTDEGLGFNVMGGKE---QNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
            VEL K D  LG +V GG     ++  IY+  +IP G AE  G + +GD++L+VNGVS+EG
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428

Query: 166  EHHEKAVELLKAAKDSVKLVV 186
              H++AVE L+     V L++
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLL 1449



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 3/80 (3%)

Query: 108  VVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++ L K+++G LGF V  G  Q    Y+  +I    A+  G LK GD+L+ VN   V   
Sbjct: 1788 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1845

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H  AV LL+AA  +V+LV+
Sbjct: 1846 THTDAVNLLRAASKTVRLVI 1865



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)

Query: 109  VELPKTDEGLGF------NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
            V+L K   GLGF      N++  +   S + + ++ PG  A   G +  GD +L VNG S
Sbjct: 1502 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561

Query: 163  VEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEEME 197
            ++G   ++ +  L+     V L++ R  P VL E++
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1597



 Score = 37.4 bits (85), Expect = 0.011
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 10/87 (11%)

Query: 109  VELPKTDEGLGFNVMGGKEQ-NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG-- 165
            + L    E LGF++ GG +     +YIS I P  VA   G L+  D +  VNGVS +G  
Sbjct: 1884 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1943

Query: 166  -EHHEKAVEL------LKAAKDSVKLV 185
             E   +A+++      LKA ++ + +V
Sbjct: 1944 LEEVNRALDMSLPSLVLKATRNDLPVV 1970


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 34/73 (46%), Positives = 49/73 (67%), Gaps = 3/73 (4%)

Query: 117  GLGFNVMGGKEQNS---PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVE 173
            GLGF ++GG++       I+IS + PGG A+  G LK GD+L+SVN VS+EG  H  A+E
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143

Query: 174  LLKAAKDSVKLVV 186
            +L+ A + V LV+
Sbjct: 1144 ILQNAPEDVTLVI 1156



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 3/81 (3%)

Query: 109  VELPKTDEGLGFNVMGGKE---QNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
            VEL K D  LG +V GG     ++  IY+  +IP G AE  G + +GD++L+VNGVS+EG
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 166  EHHEKAVELLKAAKDSVKLVV 186
              H++AVE L+     V L++
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLL 1430



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 3/80 (3%)

Query: 108  VVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++ L K+++G LGF V  G  Q    Y+  +I    A+  G LK GD+L+ VN   V   
Sbjct: 1769 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1826

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H  AV LL+AA  +V+LV+
Sbjct: 1827 THTDAVNLLRAASKTVRLVI 1846



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)

Query: 109  VELPKTDEGLGF------NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
            V+L K   GLGF      N++  +   S + + ++ PG  A   G +  GD +L VNG S
Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542

Query: 163  VEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEEME 197
            ++G   ++ +  L+     V L++ R  P VL E++
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1578



 Score = 37.4 bits (85), Expect = 0.011
 Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 10/87 (11%)

Query: 109  VELPKTDEGLGFNVMGGKEQ-NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG-- 165
            + L    E LGF++ GG +     +YIS I P  VA   G L+  D +  VNGVS +G  
Sbjct: 1865 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1924

Query: 166  -EHHEKAVEL------LKAAKDSVKLV 185
             E   +A+++      LKA ++ + +V
Sbjct: 1925 LEEVNRALDMSLPSLVLKATRNDLPVV 1951


>gi|7706025 PDZ domain containing 11 [Homo sapiens]
          Length = 140

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)

Query: 106 PRVVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
           PR + L K     LGFN+ GGK     I+IS++IP   A R  GL+ GDQ+L+VN V  +
Sbjct: 45  PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103

Query: 165 GEHHEKAVELLKAAKDSVKLVVRYTP 190
              H KAVE+LK A++ + + VR+ P
Sbjct: 104 DIEHSKAVEILKTARE-ISMRVRFFP 128


>gi|31742501 sorting nexin family member 27 [Homo sapiens]
          Length = 528

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 35/101 (34%), Positives = 58/101 (57%), Gaps = 13/101 (12%)

Query: 102 GHSHPRVVELPKTDEGLGFNVMGGKEQNSPI------------YISRIIPGGVAERHGGL 149
           G   PRVV + K++ G GFNV G   +   +            ++S ++PGG A+R  G+
Sbjct: 37  GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95

Query: 150 KRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTP 190
           ++GD++L VN V+VEG  H++ V+L++A +  + L V   P
Sbjct: 96  RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 32/86 (37%), Positives = 52/86 (60%), Gaps = 2/86 (2%)

Query: 105 HPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
           H   VEL     GLGF ++GGK   S + +  I+PGG+A+R G L+ GD +L + G +V+
Sbjct: 245 HVEEVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302

Query: 165 GEHHEKAVELLKAAKDSVKLVVRYTP 190
           G   E+  ++L+   +SV+++V   P
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVARDP 328



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 31/80 (38%), Positives = 46/80 (57%), Gaps = 1/80 (1%)

Query: 108  VVELPKTDEGLGFNVMGGKEQN-SPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            ++E+ K   GLG +++GGK+   + I I  +   G A R G L  GDQ+L VNGV +   
Sbjct: 1437 IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             HE+A+  L+     V+LVV
Sbjct: 1497 SHEEAITALRQTPQKVRLVV 1516



 Score = 55.1 bits (131), Expect = 5e-08
 Identities = 29/74 (39%), Positives = 43/74 (58%), Gaps = 1/74 (1%)

Query: 113  KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
            K   GLG +++G K   S ++IS I+ GG A+  G L +GDQ+LSVNG  +     E   
Sbjct: 1539 KAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVA 1597

Query: 173  ELLKAAKDSVKLVV 186
             +LK A+  V+L +
Sbjct: 1598 TILKCAQGLVQLEI 1611



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 4/75 (5%)

Query: 107 RVVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
           ++VEL K  +GLGF+++  ++   P    I I  ++  GVAER GGL  GD+L+SVN   
Sbjct: 685 KIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744

Query: 163 VEGEHHEKAVELLKA 177
           ++     +AVE+LKA
Sbjct: 745 LDNTSLAEAVEILKA 759



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 36/128 (28%), Positives = 69/128 (53%), Gaps = 14/128 (10%)

Query: 106  PRVVEL-PKTDEGLGFNVMGGK---------EQNSPIYISRIIPGGVAERHGGLKRGDQL 155
            PR+VE+  + +  LG +++GG+         E+   I+I +++    A +   LK GD++
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125

Query: 156  LSVNGVSVEGEHHEKAVELLKAAKDSVKLVVR---YTPKVLEEMEARFEKLRTARRRQQQ 212
            L V+GV ++   H +AVE +K A + V  +V+    TP+V+  +  +  K+ T  + Q  
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKI-TGNQNQDT 1184

Query: 213  QLLIQQQQ 220
            Q   +++Q
Sbjct: 1185 QEKKEKRQ 1192



 Score = 54.3 bits (129), Expect = 9e-08
 Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 3/90 (3%)

Query: 97   FAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNS-PIYISRIIPGGVAERHGGLKRGDQL 155
            +A   G  H  ++EL K   GLG ++ G K+++   I++  I P G A   G ++ GD+L
Sbjct: 1230 YADLPGELH--IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDEL 1287

Query: 156  LSVNGVSVEGEHHEKAVELLKAAKDSVKLV 185
            L +N   + G  H+ A  ++K A   VKLV
Sbjct: 1288 LEINNQILYGRSHQNASAIIKTAPSKVKLV 1317



 Score = 51.2 bits (121), Expect = 7e-07
 Identities = 30/86 (34%), Positives = 50/86 (58%), Gaps = 5/86 (5%)

Query: 109 VELPKTDEGLGFNVMGGKEQNS---PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
           +E P T  GLGF+V+  + QN     I++  + PG VA+R   LK  DQ+L++N   ++ 
Sbjct: 137 IERPSTG-GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQ 195

Query: 166 E-HHEKAVELLKAAKDSVKLVVRYTP 190
              H++A+ LL+    S++L+V   P
Sbjct: 196 NISHQQAIALLQQTTGSLRLIVAREP 221



 Score = 51.2 bits (121), Expect = 7e-07
 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 4/85 (4%)

Query: 106  PRVVELPKT-DEGLGFNVMGGKEQ---NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
            PR VE+ +   + LG ++ GG+     + P++I+ I   GVA R   LK GD+++S+NG 
Sbjct: 1674 PRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733

Query: 162  SVEGEHHEKAVELLKAAKDSVKLVV 186
             ++G  H   V LLK A   + L V
Sbjct: 1734 PLDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 27/84 (32%), Positives = 48/84 (57%), Gaps = 6/84 (7%)

Query: 109 VELPKTD-EGLGFNVMG-----GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
           VEL + D + LG  ++G        + S IY+  IIPG  A  +G ++  D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425

Query: 163 VEGEHHEKAVELLKAAKDSVKLVV 186
           ++G  +   VE+L+ A   V L +
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTL 449



 Score = 38.9 bits (89), Expect = 0.004
 Identities = 21/53 (39%), Positives = 29/53 (54%)

Query: 133 YISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLV 185
           YIS I+ GG  +  G L+  D+LL VNG+ + G+   +AV  LK       LV
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 34/82 (41%), Positives = 52/82 (63%), Gaps = 6/82 (7%)

Query: 111 LPKTDEGLGFNVMGGKEQ------NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
           L +++ GLGF++ GGK        ++ I++SRI  GG A R G L+ GD++LS+NGV V 
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924

Query: 165 GEHHEKAVELLKAAKDSVKLVV 186
              H+ AV LL AA  ++ L++
Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 9/101 (8%)

Query: 98   AASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSP--------IYISRIIPGGVAERHGGL 149
            AA EG      + LP+    LG +++GG + +S         ++IS+++P G+A R  GL
Sbjct: 994  AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGL 1052

Query: 150  KRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTP 190
            + GD++L+VNG  V    H++AV  L      + L+VR  P
Sbjct: 1053 RVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 31/76 (40%), Positives = 47/76 (61%), Gaps = 7/76 (9%)

Query: 117 GLGFNVMGGKEQ------NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEK 170
           GLG ++ GGK        +  I+ISR+   G A R  G++ GD+LL VNGV+++G  H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHE 795

Query: 171 AVELLKAAKDSVKLVV 186
           AVE L+ A  +V++ V
Sbjct: 796 AVEALRGAGTAVQMRV 811



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 9/80 (11%)

Query: 116  EGLGFNVMGGKEQNSP---------IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            E LG ++ GG   ++          I+IS++ P G A R G L+ G +LL VN  S+ G 
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H +AV+LL++  D++ ++V
Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 34/82 (41%), Positives = 52/82 (63%), Gaps = 6/82 (7%)

Query: 111 LPKTDEGLGFNVMGGKEQ------NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
           L +++ GLGF++ GGK        ++ I++SRI  GG A R G L+ GD++LS+NGV V 
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924

Query: 165 GEHHEKAVELLKAAKDSVKLVV 186
              H+ AV LL AA  ++ L++
Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946



 Score = 55.8 bits (133), Expect = 3e-08
 Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 9/101 (8%)

Query: 98   AASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSP--------IYISRIIPGGVAERHGGL 149
            AA EG      + LP+    LG +++GG + +S         ++IS+++P G+A R  GL
Sbjct: 994  AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGL 1052

Query: 150  KRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTP 190
            + GD++L+VNG  V    H++AV  L      + L+VR  P
Sbjct: 1053 RVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 31/76 (40%), Positives = 47/76 (61%), Gaps = 7/76 (9%)

Query: 117 GLGFNVMGGKEQ------NSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEK 170
           GLG ++ GGK        +  I+ISR+   G A R  G++ GD+LL VNGV+++G  H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHE 795

Query: 171 AVELLKAAKDSVKLVV 186
           AVE L+ A  +V++ V
Sbjct: 796 AVEALRGAGTAVQMRV 811



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 9/80 (11%)

Query: 116  EGLGFNVMGGKEQNSP---------IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGE 166
            E LG ++ GG   ++          I+IS++ P G A R G L+ G +LL VN  S+ G 
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168

Query: 167  HHEKAVELLKAAKDSVKLVV 186
             H +AV+LL++  D++ ++V
Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 38/97 (39%), Positives = 55/97 (56%), Gaps = 2/97 (2%)

Query: 98  AASEGHSHP--RVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQL 155
           A   G S P  RV  + +   GLG ++ GG+E   PI IS+I PG  A++   L+ GD +
Sbjct: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163

Query: 156 LSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKV 192
           LSVNG  +    H++AV+ LK A   V L V++  +V
Sbjct: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 10/128 (7%)

Query: 113 KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
           + + G GF ++GG E   PIYI  I+P G A+  G L+ GD+L+ V+G  V G+ H+  V
Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905

Query: 173 ELLK--AAKDSVKLVVR-----YTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQ 225
           +L++  A +  V L VR       PK   E+ +      ++    Q   L ++++  Q  
Sbjct: 906 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSS---NQPASLTEEKRTPQGS 962

Query: 226 QTQQNHMS 233
           Q   N +S
Sbjct: 963 QNSLNTVS 970



 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 29/79 (36%), Positives = 50/79 (63%)

Query: 109  VELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHH 168
            VEL +  +G GF++ GG+E N  +Y+ R+   G AER G ++ GD++L +NG + +   H
Sbjct: 1153 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1212

Query: 169  EKAVELLKAAKDSVKLVVR 187
             +A+EL+K     V+L ++
Sbjct: 1213 SRAIELIKNGGRRVRLFLK 1231



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 25/54 (46%), Positives = 34/54 (62%)

Query: 131  PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKL 184
            P  I RII G  A+R G LK GD++L+VNG S+  + H   V L+K A ++V L
Sbjct: 1035 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1088



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 22/68 (32%), Positives = 38/68 (55%)

Query: 110 ELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHE 169
           +L K+  G GF V+GG E +  + I  ++  G A   G ++ GD ++SVN   V G  H 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 170 KAVELLKA 177
           + V++ ++
Sbjct: 534 QVVKIFQS 541



 Score = 35.8 bits (81), Expect = 0.032
 Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 4/50 (8%)

Query: 180 DSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQ 229
           D +    +Y   VLE       K +  +++QQQQ   QQQQQQQQQQT++
Sbjct: 379 DHINRKTQYENPVLEAKR----KKQLEQQQQQQQQQQQQQQQQQQQQTEE 424



 Score = 33.5 bits (75), Expect = 0.16
 Identities = 16/31 (51%), Positives = 20/31 (64%)

Query: 203 LRTARRRQQQQLLIQQQQQQQQQQTQQNHMS 233
           L   R++Q +Q   QQQQQQQQQQ QQ   +
Sbjct: 392 LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQT 422



 Score = 28.9 bits (63), Expect = 3.9
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 31/121 (25%)

Query: 74  ETITVNGCPEFRARATAKATVAAFAASEGHSHPR----------------VVELPKTDEG 117
           +T  VNG  +  AR ++ A VA+   +  H +P                  V + K   G
Sbjct: 598 KTGKVNGMKD--ARPSSPADVAS---NSSHGYPNDTVSLASSIATQPELITVHIVKGPMG 652

Query: 118 LGFNVM---GGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVEL 174
            GF +    GG  Q     + +I+    + R  GLK GD ++ VN  +V+   H + V++
Sbjct: 653 FGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705

Query: 175 L 175
           L
Sbjct: 706 L 706


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 10/128 (7%)

Query: 113 KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
           + + G GF ++GG E   PIYI  I+P G A+  G L+ GD+L+ V+G  V G+ H+  V
Sbjct: 818 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 877

Query: 173 ELLK--AAKDSVKLVVR-----YTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQ 225
           +L++  A +  V L VR       PK   E+ +      ++    Q   L ++++  Q  
Sbjct: 878 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSS---NQPASLTEEKRTPQGS 934

Query: 226 QTQQNHMS 233
           Q   N +S
Sbjct: 935 QNSLNTVS 942



 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 29/79 (36%), Positives = 50/79 (63%)

Query: 109  VELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHH 168
            VEL +  +G GF++ GG+E N  +Y+ R+   G AER G ++ GD++L +NG + +   H
Sbjct: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183

Query: 169  EKAVELLKAAKDSVKLVVR 187
             +A+EL+K     V+L ++
Sbjct: 1184 SRAIELIKNGGRRVRLFLK 1202



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 25/54 (46%), Positives = 34/54 (62%)

Query: 131  PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKL 184
            P  I RII G  A+R G LK GD++L+VNG S+  + H   V L+K A ++V L
Sbjct: 1006 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1059



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 22/68 (32%), Positives = 38/68 (55%)

Query: 110 ELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHE 169
           +L K+  G GF V+GG E +  + I  ++  G A   G ++ GD ++SVN   V G  H 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 170 KAVELLKA 177
           + V++ ++
Sbjct: 534 QVVKIFQS 541



 Score = 35.8 bits (81), Expect = 0.032
 Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 4/50 (8%)

Query: 180 DSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQ 229
           D +    +Y   VLE       K +  +++QQQQ   QQQQQQQQQQT++
Sbjct: 379 DHINRKTQYENPVLEAKR----KKQLEQQQQQQQQQQQQQQQQQQQQTEE 424



 Score = 33.5 bits (75), Expect = 0.16
 Identities = 16/31 (51%), Positives = 20/31 (64%)

Query: 203 LRTARRRQQQQLLIQQQQQQQQQQTQQNHMS 233
           L   R++Q +Q   QQQQQQQQQQ QQ   +
Sbjct: 392 LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQT 422



 Score = 28.9 bits (63), Expect = 3.9
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 31/121 (25%)

Query: 74  ETITVNGCPEFRARATAKATVAAFAASEGHSHPR----------------VVELPKTDEG 117
           +T  VNG  +  AR ++ A VA+   +  H +P                  V + K   G
Sbjct: 598 KTGKVNGMKD--ARPSSPADVAS---NSSHGYPNDTVSLASSIATQPELITVHIVKGPMG 652

Query: 118 LGFNVM---GGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVEL 174
            GF +    GG  Q     + +I+    + R  GLK GD ++ VN  +V+   H + V++
Sbjct: 653 FGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705

Query: 175 L 175
           L
Sbjct: 706 L 706


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 10/128 (7%)

Query: 113 KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
           + + G GF ++GG E   PIYI  I+P G A+  G L+ GD+L+ V+G  V G+ H+  V
Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905

Query: 173 ELLK--AAKDSVKLVVR-----YTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQ 225
           +L++  A +  V L VR       PK   E+ +      ++    Q   L ++++  Q  
Sbjct: 906 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSS---NQPASLTEEKRTPQGS 962

Query: 226 QTQQNHMS 233
           Q   N +S
Sbjct: 963 QNSLNTVS 970



 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 29/79 (36%), Positives = 50/79 (63%)

Query: 109  VELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHH 168
            VEL +  +G GF++ GG+E N  +Y+ R+   G AER G ++ GD++L +NG + +   H
Sbjct: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211

Query: 169  EKAVELLKAAKDSVKLVVR 187
             +A+EL+K     V+L ++
Sbjct: 1212 SRAIELIKNGGRRVRLFLK 1230



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 25/54 (46%), Positives = 34/54 (62%)

Query: 131  PIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKL 184
            P  I RII G  A+R G LK GD++L+VNG S+  + H   V L+K A ++V L
Sbjct: 1034 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1087



 Score = 45.4 bits (106), Expect = 4e-05
 Identities = 22/68 (32%), Positives = 38/68 (55%)

Query: 110 ELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHE 169
           +L K+  G GF V+GG E +  + I  ++  G A   G ++ GD ++SVN   V G  H 
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533

Query: 170 KAVELLKA 177
           + V++ ++
Sbjct: 534 QVVKIFQS 541



 Score = 35.8 bits (81), Expect = 0.032
 Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 4/50 (8%)

Query: 180 DSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQ 229
           D +    +Y   VLE       K +  +++QQQQ   QQQQQQQQQQT++
Sbjct: 379 DHINRKTQYENPVLEAKR----KKQLEQQQQQQQQQQQQQQQQQQQQTEE 424



 Score = 33.5 bits (75), Expect = 0.16
 Identities = 16/31 (51%), Positives = 20/31 (64%)

Query: 203 LRTARRRQQQQLLIQQQQQQQQQQTQQNHMS 233
           L   R++Q +Q   QQQQQQQQQQ QQ   +
Sbjct: 392 LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQT 422



 Score = 28.9 bits (63), Expect = 3.9
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 31/121 (25%)

Query: 74  ETITVNGCPEFRARATAKATVAAFAASEGHSHPR----------------VVELPKTDEG 117
           +T  VNG  +  AR ++ A VA+   +  H +P                  V + K   G
Sbjct: 598 KTGKVNGMKD--ARPSSPADVAS---NSSHGYPNDTVSLASSIATQPELITVHIVKGPMG 652

Query: 118 LGFNVM---GGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVEL 174
            GF +    GG  Q     + +I+    + R  GLK GD ++ VN  +V+   H + V++
Sbjct: 653 FGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705

Query: 175 L 175
           L
Sbjct: 706 L 706


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score = 64.3 bits (155), Expect = 8e-11
 Identities = 38/105 (36%), Positives = 61/105 (58%), Gaps = 14/105 (13%)

Query: 86  ARATAKATVAAFAASEGHSHPRV-----VELPKTDEGLGFNV------MGGKEQNSPIYI 134
           A A+A   V +   S G++  ++     ++L K  EGLGF++      +GG   ++PIY+
Sbjct: 434 APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGG---SAPIYV 490

Query: 135 SRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAK 179
             I+P G A + G LK GD+L+ VNGV + G+  E+ V LL++ K
Sbjct: 491 KNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTK 535



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 7/74 (9%)

Query: 110 ELPKTDEG---LGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
           E+P  D G   LG +V G + + +     I++  II GG A + G L+  DQL++VNG S
Sbjct: 590 EVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGES 649

Query: 163 VEGEHHEKAVELLK 176
           + G+ ++ A+E L+
Sbjct: 650 LLGKTNQDAMETLR 663


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score = 64.3 bits (155), Expect = 8e-11
 Identities = 32/72 (44%), Positives = 43/72 (59%)

Query: 117 GLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK 176
           GLG ++ GG E N P+ IS+I     A++ G L  GD +L VNG+ VE   HE+ V LL+
Sbjct: 83  GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142

Query: 177 AAKDSVKLVVRY 188
            A D V + V Y
Sbjct: 143 NAGDEVTITVEY 154


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,793,734
Number of Sequences: 37866
Number of extensions: 326929
Number of successful extensions: 7074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 2791
Number of HSP's gapped (non-prelim): 2172
length of query: 233
length of database: 18,247,518
effective HSP length: 99
effective length of query: 134
effective length of database: 14,498,784
effective search space: 1942837056
effective search space used: 1942837056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.