Search of human proteins with 13194201

Search of human proteins with 13194201

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
         (473 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13194201 reticulon 4 receptor precursor [Homo sapiens]             985   0.0  
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                312   5e-85
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                305   6e-83
gi|225579152 insulin-like growth factor binding protein, acid la...   131   2e-30
gi|4826772 insulin-like growth factor binding protein, acid labi...   131   2e-30
gi|194440719 chondroadherin-like [Homo sapiens]                       130   3e-30
gi|12007646 nyctalopin precursor [Homo sapiens]                       130   3e-30
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           130   3e-30
gi|51317373 netrin-G1 ligand [Homo sapiens]                           129   8e-30
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         127   2e-29
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         126   4e-29
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               126   4e-29
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   120   3e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   119   8e-27
gi|188528675 slit homolog 1 [Homo sapiens]                            116   4e-26
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             116   5e-26
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             116   5e-26
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   115   7e-26
gi|88702793 slit-like 2 [Homo sapiens]                                114   3e-25
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   111   2e-24
gi|198041768 synleurin [Homo sapiens]                                 110   2e-24
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   110   4e-24
gi|153251229 chondroadherin precursor [Homo sapiens]                  109   5e-24
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   109   6e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   108   1e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   108   1e-23
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]       105   7e-23
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]       105   7e-23
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]       105   7e-23
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]       105   7e-23

>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score =  985 bits (2546), Expect = 0.0
 Identities = 473/473 (100%), Positives = 473/473 (100%)

Query: 1   MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ 60
           MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ
Sbjct: 1   MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ 60

Query: 61  RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS 120
           RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS
Sbjct: 61  RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS 120

Query: 121 VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL 180
           VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL
Sbjct: 121 VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL 180

Query: 181 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA 240
           THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA
Sbjct: 181 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA 240

Query: 241 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR 300
           LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR
Sbjct: 241 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR 300

Query: 301 LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK 360
           LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK
Sbjct: 301 LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK 360

Query: 361 GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS 420
           GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS
Sbjct: 361 GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS 420

Query: 421 RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC 473
           RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
Sbjct: 421 RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC 473


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score =  312 bits (799), Expect = 5e-85
 Identities = 184/414 (44%), Positives = 232/414 (56%), Gaps = 21/414 (5%)

Query: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
           CP  CVCY  P +T SC      A+P GIP  S+R+FL  NRI  +    F     +  L
Sbjct: 25  CPRDCVCYPAP-MTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTL 81

Query: 87  WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
           W++SN +  I  + F G   LE+LDL DN QLR++ P TF GL +LH L+L +CGL  L 
Sbjct: 82  WIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALP 141

Query: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
            G+F GL +LQYLYLQDN ++ L DD F DL NL+HLFLHGN++ S+    FRGL +LDR
Sbjct: 142 AGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDR 201

Query: 207 LLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDC 266
           LLLH+N++  VH  AF DL RL TL+LF N+LS L  E LAPL AL++LRLN NPW C C
Sbjct: 202 LLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGC 261

Query: 267 RARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATD 326
           RAR LW WLQ+FRGSSS VPC  P    G+DLK L A D + C   TGP  P        
Sbjct: 262 RARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNC---TGPASP-------- 310

Query: 327 EEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHIND-SPFG 385
              +        D A +     P  P  +     G  P    P  N + PR+ N  S  G
Sbjct: 311 -HQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAG 369

Query: 386 TLPGSAEPPLTAVRPEGSEPPGF---PTSGPRRRPGCSRKNRTRSHCRLGQAGS 436
              G   P L    P+      F   PT+ P+R+  C+R+   R+   + QA S
Sbjct: 370 A--GKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASS 421


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  305 bits (781), Expect = 6e-83
 Identities = 175/358 (48%), Positives = 216/358 (60%), Gaps = 13/358 (3%)

Query: 15  VLWLQAWQVAAP-CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVP 73
           +L L A  +AAP CP  C CY+ P  T SC      +VP+ +P ++QR+FL  N I  + 
Sbjct: 18  LLMLLALPLAAPSCPMLCTCYSSPP-TVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLR 76

Query: 74  AASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLH 133
             +F +  NL  LWL SN L+ I    F  L  LE+LDL DN  LRS++P TF GL RL 
Sbjct: 77  PGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQ 134

Query: 134 TLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSV 193
           +LHL RC L  L   +FRGL +LQYLYLQ+N+L  L DD F DL NL+HLFLHGNR+  +
Sbjct: 135 SLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLL 194

Query: 194 PERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQ 253
            E  FRGL SLDRLLLH NR+  VH  AFR L RL  LYLF N+L++LP EALA L +L+
Sbjct: 195 TEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLE 254

Query: 254 YLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVAT 313
           +LRLN NPW CDCRARPLWAW Q+ R SSS+V C+ P    GRDL+ L   D Q C  A 
Sbjct: 255 FLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACPPA- 313

Query: 314 GPYHP--IWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSP 369
            P  P     G ++     G+ +   P A    S L    PA      +G    GD+P
Sbjct: 314 APTRPGSRARGNSSSNHLYGVAEAGAPPA--DPSTLYRDLPAEDSRGRQG----GDAP 365


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  131 bits (329), Expect = 2e-30
 Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 4/237 (1%)

Query: 27  CPGACVC-YNEP--KVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
           CP ACVC Y++   +++  C  + L  +P G+P  +Q ++L GN +S VP A+F+   +L
Sbjct: 79  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138

Query: 84  TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
             L L    L  ++  A  GL  L  L L  N QLRS+   TF     L +L L    L 
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNNRLS 197

Query: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
            L  GLF GL +L  L L  N+L  LPD  FR LG+L  L L GNR++ +    F GL  
Sbjct: 198 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 257

Query: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
           L  L L +N +  +  + F  L RL  LYL  N ++A+   A   L+AL++L L+ N
Sbjct: 258 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 314



 Score =  126 bits (316), Expect = 5e-29
 Identities = 81/232 (34%), Positives = 115/232 (49%), Gaps = 21/232 (9%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + + L  NRI  +   SF     L +L L  N L  + A AF GL  +  ++LS N  LR
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 413

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
           ++    F GLG+LH+LHL+   L  + P  F GL+ L+ L+L+DN L  + + +   L  
Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L L  N+++ +P R F+GL  L+ LLL +NR+A +   A   L R   L +  N L 
Sbjct: 474 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 533

Query: 240 ALPTEALAPLRALQYLRLND--------------------NPWVCDCRARPL 271
           ALP   LAPL  L+YL L +                    NPW C C  + L
Sbjct: 534 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKAL 585



 Score =  109 bits (273), Expect = 5e-24
 Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 1/194 (0%)

Query: 67  NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126
           N ++ +P A+FR   +L  L L  N LA +  A F+GLA L +LDLS NA LR++    F
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVF 276

Query: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186
             L RL  L+LDR  +  + PG F GL AL++L L  N +  L +DTF  L  L  L L 
Sbjct: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 336

Query: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246
            N I+S+  R F+ LH L+ L L  NR+  +   +F  LG+L  L L  N L  +   A 
Sbjct: 337 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396

Query: 247 APLRALQYLRLNDN 260
             L  +  + L+ N
Sbjct: 397 LGLTNVAVMNLSGN 410



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 1/201 (0%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           Q+++L  N I+ V   +F   + L  L L  N +A +    F GL  L  L LS NA + 
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-IA 341

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
           S+ P TF  L  L  L L    +++L    F GL  L+ L L  N LQ +    F  L N
Sbjct: 342 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 401

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           +  + L GN + ++PE+ FRGL  L  L L  + +  + PH F  L  L  L+L  N L 
Sbjct: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461

Query: 240 ALPTEALAPLRALQYLRLNDN 260
            +  ++L  L  L  L L  N
Sbjct: 462 GIEEQSLWGLAELLELDLTSN 482


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  131 bits (329), Expect = 2e-30
 Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 4/237 (1%)

Query: 27  CPGACVC-YNEP--KVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
           CP ACVC Y++   +++  C  + L  +P G+P  +Q ++L GN +S VP A+F+   +L
Sbjct: 41  CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100

Query: 84  TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
             L L    L  ++  A  GL  L  L L  N QLRS+   TF     L +L L    L 
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNNRLS 159

Query: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
            L  GLF GL +L  L L  N+L  LPD  FR LG+L  L L GNR++ +    F GL  
Sbjct: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219

Query: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
           L  L L +N +  +  + F  L RL  LYL  N ++A+   A   L+AL++L L+ N
Sbjct: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276



 Score =  126 bits (316), Expect = 5e-29
 Identities = 81/232 (34%), Positives = 115/232 (49%), Gaps = 21/232 (9%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + + L  NRI  +   SF     L +L L  N L  + A AF GL  +  ++LS N  LR
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 375

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
           ++    F GLG+LH+LHL+   L  + P  F GL+ L+ L+L+DN L  + + +   L  
Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L L  N+++ +P R F+GL  L+ LLL +NR+A +   A   L R   L +  N L 
Sbjct: 436 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 495

Query: 240 ALPTEALAPLRALQYLRLND--------------------NPWVCDCRARPL 271
           ALP   LAPL  L+YL L +                    NPW C C  + L
Sbjct: 496 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKAL 547



 Score =  109 bits (273), Expect = 5e-24
 Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 1/194 (0%)

Query: 67  NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126
           N ++ +P A+FR   +L  L L  N LA +  A F+GLA L +LDLS NA LR++    F
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVF 238

Query: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186
             L RL  L+LDR  +  + PG F GL AL++L L  N +  L +DTF  L  L  L L 
Sbjct: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 298

Query: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246
            N I+S+  R F+ LH L+ L L  NR+  +   +F  LG+L  L L  N L  +   A 
Sbjct: 299 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358

Query: 247 APLRALQYLRLNDN 260
             L  +  + L+ N
Sbjct: 359 LGLTNVAVMNLSGN 372



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 1/201 (0%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           Q+++L  N I+ V   +F   + L  L L  N +A +    F GL  L  L LS NA + 
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-IA 303

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
           S+ P TF  L  L  L L    +++L    F GL  L+ L L  N LQ +    F  L N
Sbjct: 304 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           +  + L GN + ++PE+ FRGL  L  L L  + +  + PH F  L  L  L+L  N L 
Sbjct: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423

Query: 240 ALPTEALAPLRALQYLRLNDN 260
            +  ++L  L  L  L L  N
Sbjct: 424 GIEEQSLWGLAELLELDLTSN 444


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  130 bits (327), Expect = 3e-30
 Identities = 118/349 (33%), Positives = 147/349 (42%), Gaps = 60/349 (17%)

Query: 11  LLAWVLWLQAWQVAAP-CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRI 69
           LL  +L   A Q AA  CP AC+C N  +   +C  Q L  VP  IP  +QR+ L GN +
Sbjct: 16  LLVLLLLAPARQAAAQRCPQACICDNSRR-HVACRYQNLTEVPDAIPELTQRLDLQGNLL 74

Query: 70  SHVPAASFRACRNLT------------------------ILWLHSNVLARIDAAAFTGLA 105
             +PAA+F+   +LT                        +L L SN L  +   A  GL 
Sbjct: 75  KVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLG 134

Query: 106 LLEQLDLSDNAQLRSVDPATFHGLGRLHTLHL------------------------DRCG 141
            L +L+L  NA L  + P TF  LG L TL+L                            
Sbjct: 135 SLRRLELEGNA-LEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNA 193

Query: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL 201
           L  L P    GL AL+ L L  N LQALP         L  L L  N ++   E     L
Sbjct: 194 LSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLAL 253

Query: 202 HSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRA---LQYLRLN 258
             L  LLL    +  + P AF    RL TL L  N L  LP     PL+    L+ LRL 
Sbjct: 254 PGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP-----PLQGPGQLRRLRLQ 308

Query: 259 DNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQ 307
            NP  C C+ARPL  WL + R   S+  C  P+RL G  L  L   DL+
Sbjct: 309 GNPLWCGCQARPLLEWLARAR-VRSDGACQGPRRLRGEALDALRPWDLR 356



 Score =  129 bits (323), Expect = 8e-30
 Identities = 115/364 (31%), Positives = 153/364 (42%), Gaps = 68/364 (18%)

Query: 22  QVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACR 81
           +  APCP ACVC  E +  +SC   GLQAVP G P+ +Q + L  N    VP A+F    
Sbjct: 391 RAVAPCPRACVCVPESR-HSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLG 449

Query: 82  NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCG 141
           +L  L L    +A ++A A  GL  L  L LSDN QL  +  A   G  RL  L+L+R  
Sbjct: 450 HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDN-QLAGLSAAALEGAPRLGYLYLERNR 508

Query: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSV------PE 195
             ++     R L +L  L+LQDNA+  L          L  ++L GNRI+ V      P 
Sbjct: 509 FLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPA 568

Query: 196 RAFRGLH-------------------------------------------SLDRLLLHQN 212
           R    LH                                           SL  L L+ +
Sbjct: 569 RELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSS 628

Query: 213 RVAHVHPHAFRDLG-RLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPL 271
            +  + P AF  LG  L +L+L  N L ALP  AL  L  L+ + L+ NP+ CDC+  PL
Sbjct: 629 GLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPL 686

Query: 272 WAWLQKFRGSSSEV--PCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEP 329
             WL    G +  V   C+ P    G+ +K  AA   + C        P W  R     P
Sbjct: 687 HRWL---TGLNLRVGATCATPPNARGQRVKAAAA-VFEDC--------PGWAARKAKRTP 734

Query: 330 LGLP 333
              P
Sbjct: 735 ASRP 738


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  130 bits (326), Expect = 3e-30
 Identities = 113/357 (31%), Positives = 151/357 (42%), Gaps = 76/357 (21%)

Query: 20  AWQVAA---PCPGACVCYN-EPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAA 75
           AW V A    CP AC C   E   +  C + GL  VP  +P  +  I L  N +  +   
Sbjct: 21  AWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGER 80

Query: 76  SFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTL 135
           +F    +L  L L  N L+ I   AF GL  L +L L+ N  LR +   TF  L RL  L
Sbjct: 81  AFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 140

Query: 136 HLDRC--------------GLQELG---------PGLFRGLAALQY-------------- 158
            L  C               L+EL          PG  RGLA L +              
Sbjct: 141 DLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASS 200

Query: 159 ----------LYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL------- 201
                     L LQ N ++A+    F D G L HL L+ N ++ +P  AFRGL       
Sbjct: 201 SLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLN 260

Query: 202 ---HSLDR--------------LLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE 244
              ++LDR              L L +N +A V   AF++L  L+ L+L  N L+ L   
Sbjct: 261 LGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWV 320

Query: 245 ALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRL 301
           A  P   L  L L  NPW CDCR   L  W++   G  ++VPC+ P  +AG DL ++
Sbjct: 321 AFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG-SGRVTDVPCASPGSVAGLDLSQV 376


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  130 bits (326), Expect = 3e-30
 Identities = 101/300 (33%), Positives = 143/300 (47%), Gaps = 33/300 (11%)

Query: 27  CPGACVCYNE-PKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTI 85
           CP  C C N+  KV   C ++GL  VP GIP+ ++ + L  N I  + A +FR   +L +
Sbjct: 46  CPSVCSCSNQFSKVV--CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV 103

Query: 86  LWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLD------- 138
           L L  N + +I+  AF GLA L  L+L DN  L  +    F  L +L  L L        
Sbjct: 104 LQLGRNSIRQIEVGAFNGLASLNTLELFDN-WLTVIPSGAFEYLSKLRELWLRNNPIESI 162

Query: 139 ------------RCGLQEL------GPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL 180
                       R  L EL        G F GL  L+YL L    ++ +P+ T   L  L
Sbjct: 163 PSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLT--PLVGL 220

Query: 181 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA 240
             L + GN    +   +F GL SL +L +  ++V+ +  +AF  L  L+ L L  NNLS+
Sbjct: 221 EELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSS 280

Query: 241 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEV--PCSLPQRLAGRDL 298
           LP +   PLR L  L L+ NPW CDC    L  WL+++  ++S     C  P  + GR L
Sbjct: 281 LPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYL 340


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  129 bits (323), Expect = 8e-30
 Identities = 106/323 (32%), Positives = 157/323 (48%), Gaps = 34/323 (10%)

Query: 11  LLAWVLWLQAWQVAAP-CPGACVCYNE-PKVTTSCPQQGLQAVPVGIPAASQRIFLHGNR 68
           LLA  L + A  V A  CP  C C N+  KV   C ++ L+ VP GI   ++ + LH N+
Sbjct: 30  LLALQLLVVAGLVRAQTCPSVCSCSNQFSKVI--CVRKNLREVPDGISTNTRLLNLHENQ 87

Query: 69  ISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHG 128
           I  +   SF+  R+L IL L  N +  I+  AF GLA L  L+L DN +L ++    F  
Sbjct: 88  IQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDN-RLTTIPNGAFVY 146

Query: 129 LGRLHTL-------------------HLDRCGLQEL------GPGLFRGLAALQYLYLQD 163
           L +L  L                    L R  L EL        G F GL+ L+YL L  
Sbjct: 147 LSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAM 206

Query: 164 NALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFR 223
             L+ +P+ T   L  L  L L GN +S++   +F+GL  L +L + Q+++  +  +AF 
Sbjct: 207 CNLREIPNLT--PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFD 264

Query: 224 DLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSS 283
           +L  L+ + L  NNL+ LP +   PL  L+ + L+ NPW C+C    L  W++    S++
Sbjct: 265 NLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNT 324

Query: 284 E--VPCSLPQRLAGRDLKRLAAN 304
                C+ P  L GR +  L  N
Sbjct: 325 ACCARCNTPPNLKGRYIGELDQN 347


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  127 bits (320), Expect = 2e-29
 Identities = 102/305 (33%), Positives = 142/305 (46%), Gaps = 31/305 (10%)

Query: 24  AAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
           A  CP AC C N+      C ++ L  VP  IP  ++ + L  N I  +   +F+  R+L
Sbjct: 54  ATSCPVACSCSNQAS-RVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHL 112

Query: 84  TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTL-------- 135
            IL L  N++ +I+  AF GL  L  L+L DN +L +V    F  L +L  L        
Sbjct: 113 EILQLSKNLVRKIEVGAFNGLPSLNTLELFDN-RLTTVPTQAFEYLSKLRELWLRNNPIE 171

Query: 136 -----------HLDRCGLQEL------GPGLFRGLAALQYLYLQDNALQALPDDTFRDLG 178
                       L R  L EL          F GL  L+YL L    L+ +P+ T   L 
Sbjct: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTA--LV 229

Query: 179 NLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL 238
            L  L L GNR+  +   +F+GL SL +L L   +VA +  +AF DL  L  L L  NNL
Sbjct: 230 RLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL 289

Query: 239 SALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSE--VPCSLPQRLAGR 296
            +LP +   PL  L+ + LN NPW C+C    L  WL++   S++     C  P  L GR
Sbjct: 290 MSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGR 349

Query: 297 DLKRL 301
            +  L
Sbjct: 350 YIGEL 354


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  126 bits (317), Expect = 4e-29
 Identities = 122/426 (28%), Positives = 167/426 (39%), Gaps = 102/426 (23%)

Query: 24  AAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
           AA CP AC CY+    T  C    L+ VP+GIP  +Q +FL  N I+ +   +      L
Sbjct: 20  AAGCPAACRCYS---ATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAAL 76

Query: 84  TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
             L+LH+N L  ++A AF     L +L L+ N                          L+
Sbjct: 77  RRLYLHNNSLRALEAGAFRAQPRLLELALTSNR-------------------------LR 111

Query: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
            L  G F GLA L+ LYL  N L  L D TF  L  L  L L  N I  + ++A  GL S
Sbjct: 112 GLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSS 171

Query: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWV 263
           L  L L +N+                        L  +  EAL PL +LQ LRL +NPW 
Sbjct: 172 LALLDLSRNQ------------------------LGTISREALQPLASLQVLRLTENPWR 207

Query: 264 CDCRARPLWAWLQK-----FRGSSSEVPCSLPQRLAGRDL-------------------K 299
           CDC    L AW+++           ++ C+ P RLA + L                    
Sbjct: 208 CDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPL 267

Query: 300 RLAAN---DLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASA- 355
            L AN   DL+    A+G   P+ T R   +   G P+     A  +  +L  G  +++ 
Sbjct: 268 ELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRA---QAQLEGGLLGLGGHSASD 324

Query: 356 --------GNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGS--------AEPPLTAVR 399
                    N         +    N  G   +   PF  L  +        A+PP  A R
Sbjct: 325 TGSGMLFLSNITLAHAGKYECEASNAGGAARV---PFRLLVNASRQQPQQPAQPPPPAAR 381

Query: 400 PEGSEP 405
           P GSEP
Sbjct: 382 PAGSEP 387


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  126 bits (317), Expect = 4e-29
 Identities = 96/257 (37%), Positives = 122/257 (47%), Gaps = 5/257 (1%)

Query: 61  RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS 120
           ++ L GN +  +P A F    NL  L L SN +  +   AF  L  L  L+LS N    S
Sbjct: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218

Query: 121 V-DPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
           +   ATF  L  L +L L    LQ LGP +F+ L  L  L L+ N L  L  + F  L  
Sbjct: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEA 278

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L L GNR+S +P      LHSL+ L L  N ++ +HP  F  LGRL  L L  N LS
Sbjct: 279 LRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338

Query: 240 ALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGS----SSEVPCSLPQRLAG 295
           AL  +  A   AL  L L+ N W CDCR R L  W+  +       +  V C  P  L G
Sbjct: 339 ALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRG 398

Query: 296 RDLKRLAANDLQGCAVA 312
           + L  L    LQ  + A
Sbjct: 399 KYLDYLDDQQLQNGSCA 415



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 78/236 (33%), Positives = 107/236 (45%), Gaps = 25/236 (10%)

Query: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
           CP  C C +   +   C  +GL+ VP               + S +P+       ++   
Sbjct: 27  CPERCDCQHPQHLL--CTNRGLRVVP---------------KTSSLPSP-----HDVLTY 64

Query: 87  WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
            L  N +  I A  F  L  L +LDL  N Q+RS+ P TF  L RL  L+L    LQ L 
Sbjct: 65  SLGGNFITNITAFDFHRLGQLRRLDLQYN-QIRSLHPKTFEKLSRLEELYLGNNLLQALA 123

Query: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
           PG    L  L+ LY   N +  L   +F  L +L  L L GN + ++P+  F  L +L  
Sbjct: 124 PGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLY 183

Query: 207 LLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL--SALPTEALAPLRALQYLRLNDN 260
           L L  NR+  +  +AF  LG+L  L L AN L  S       APLR+L  L L+ N
Sbjct: 184 LHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 37/107 (34%), Positives = 45/107 (42%), Gaps = 25/107 (23%)

Query: 58  ASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQ 117
           A + + L GNR+S +P A            LHS                LE LDLS N +
Sbjct: 278 ALRELRLEGNRLSQLPTALLEP--------LHS----------------LEALDLSGN-E 312

Query: 118 LRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
           L ++ PATF  LGRL  L L    L  L   +F    AL  L L  N
Sbjct: 313 LSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  120 bits (301), Expect = 3e-27
 Identities = 98/312 (31%), Positives = 139/312 (44%), Gaps = 54/312 (17%)

Query: 48  LQAVPVGI---PAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGL 104
           L+A+P G+    AA + + L GN++  +P   F+   +L  L L  N+LA++    F  L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192

Query: 105 ALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
             L+ L LS+NA L  +    F  LG L  L LD   + EL P +F  L  L+ L+LQ N
Sbjct: 193 TSLQTLKLSNNA-LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251

Query: 165 ALQALPDDTFRDLGNLTHLFLHGN------------------------RISSVPERAFRG 200
           A+  LP   F  LGNLT L L  N                        ++ +V E  F  
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAH 311

Query: 201 LHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
           L +L  L+L  N + H+    FRDL  L+ LYL +NNL+AL       L  L+ L L+ N
Sbjct: 312 LSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKN 371

Query: 261 ------------------------PWVCDCRARPLWAWLQKF--RGSSSEVPCSLPQRLA 294
                                   PW CDC    L+ WLQ++  R  + +  C+ P  L 
Sbjct: 372 QLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLK 431

Query: 295 GRDLKRLAANDL 306
           G+ +  L    L
Sbjct: 432 GQVVPALNEKQL 443



 Score =  115 bits (288), Expect = 9e-26
 Identities = 85/251 (33%), Positives = 126/251 (50%), Gaps = 7/251 (2%)

Query: 13  AWVLW---LQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRI 69
           AW+LW   L   + A PCP  C C+ +      C  + L  VP+ IP  ++ I       
Sbjct: 5   AWLLWTSLLLLARPAQPCPMGCDCFVQ---EVFCSDEELATVPLDIPPYTKNIIFVETSF 61

Query: 70  SHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGL 129
           + +   +F +  NLT +   +  L +    AF GL  LE L+++ ++ L ++    F  L
Sbjct: 62  TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFL-NLSTNIFSNL 120

Query: 130 GRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNR 189
             L  L L+   L+ L  GLF+ LAAL+ L+LQ N LQALP   F+ L +L  L L  N 
Sbjct: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180

Query: 190 ISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPL 249
           ++ +PE  F  L SL  L L  N ++ +    F  LG L  L+L +NN+S LP +  + L
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240

Query: 250 RALQYLRLNDN 260
             L+ L L  N
Sbjct: 241 FCLERLWLQRN 251


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  119 bits (297), Expect = 8e-27
 Identities = 86/239 (35%), Positives = 123/239 (51%), Gaps = 6/239 (2%)

Query: 24  AAP--CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACR 81
           AAP  C   C C  + +V   C  +GL AVP G+ A +Q + +  N I+ +P  +F+   
Sbjct: 24  AAPPLCAAPCSCDGDRRV--DCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFP 81

Query: 82  NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCG 141
            L  L L  N L+ I   A +GL  L+ L L +N QL++V      GL  L +L LD   
Sbjct: 82  FLEELQLAGNDLSFIHPKALSGLKELKVLTLQNN-QLKTVPSEAIRGLSALQSLRLDANH 140

Query: 142 LQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGL 201
           +  +    F GL  L++L+L DN+L  +P     +L  L  L L  N+ISS+P+ AF  L
Sbjct: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNL 200

Query: 202 HSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
            SL  L LH N++  +  H F  L  L TL L  NNL   P +A+  L +L+ L  + N
Sbjct: 201 SSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSN 258



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 64/212 (30%), Positives = 95/212 (44%), Gaps = 25/212 (11%)

Query: 64  LHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDP 123
           L+ N +   P A  +A  +L  L  HSN ++ I   AF G  LL  + L DN  L  V  
Sbjct: 232 LNYNNLGEFPQA-IKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP-LSFVGN 289

Query: 124 ATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDD----------- 172
           + FH L  LH+L +    + +  P L  G   L+ L L    + ++P++           
Sbjct: 290 SAFHNLSDLHSLVIRGASMVQQFPNL-TGTVHLESLTLTGTKISSIPNNLCQEQKMLRTL 348

Query: 173 -----TFRDLGN------LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHA 221
                  RDL +      L  + L  N+I  + E  F+GL SL  L L +N +  +H  A
Sbjct: 349 DLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRA 408

Query: 222 FRDLGRLMTLYLFANNLSALPTEALAPLRALQ 253
           F  LG +  L +  N L++ PTE L  L  L+
Sbjct: 409 FATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  116 bits (291), Expect = 4e-26
 Identities = 90/304 (29%), Positives = 135/304 (44%), Gaps = 54/304 (17%)

Query: 4   ASAGGSRLLAWVL-WLQAWQV-AAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQR 61
           +SAG  R   W+L W  AW++ A+ CP  C C      T  C   GLQA+P  IP  ++R
Sbjct: 9   SSAGPVRPELWLLLWAAAWRLGASACPALCTCTG---TTVDCHGTGLQAIPKNIPRNTER 65

Query: 62  IFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSV 121
           + L+GN I+ +    F   + L +L L  N +  ++  AF  +  LE+L L+ N      
Sbjct: 66  LELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRN------ 119

Query: 122 DPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLT 181
                        LH+    L EL   LF+   AL  L L +NA+QA+P   FR   +L 
Sbjct: 120 ------------QLHM----LPEL---LFQNNQALSRLDLSENAIQAIPRKAFRGATDLK 160

Query: 182 HLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSAL 241
           +L L  N+IS + E AFR L  L+ L L+                         NN++ +
Sbjct: 161 NLQLDKNQISCIEEGAFRALRGLEVLTLNN------------------------NNITTI 196

Query: 242 PTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRL 301
           P  +   +  L+  RL+ N   CDC    L  WL++         CS P  L G ++  +
Sbjct: 197 PVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEV 256

Query: 302 AAND 305
             ++
Sbjct: 257 QKSE 260



 Score =  104 bits (260), Expect = 2e-22
 Identities = 55/167 (32%), Positives = 94/167 (56%)

Query: 135 LHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVP 194
           + L+  G++ + PG F     L+ + L +N +  +  D F+ L +L  L L+GN+I+ +P
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373

Query: 195 ERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQY 254
              F GL++L  LLL+ N++  + P AF+DL  L  L L+ N + +L       LRA+Q 
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQT 433

Query: 255 LRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRL 301
           L L  NP++CDC  + L  +L+     +S   C+ P+RLA + + ++
Sbjct: 434 LHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 46/160 (28%), Positives = 80/160 (50%)

Query: 148 GLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRL 207
           G+F+ L  L+ + L +N +  + D  F    +++ L L  N++ S+    FRGL  L  L
Sbjct: 559 GMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618

Query: 208 LLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCR 267
           +L  NR++ +H  +F  L  +  L L+ N ++ +   A   L++L  L L  NP+ C+C+
Sbjct: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678

Query: 268 ARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQ 307
              L  WL+K +  +    C  P  L    L+ +A  D +
Sbjct: 679 LAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR 718



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 54/186 (29%), Positives = 85/186 (45%), Gaps = 27/186 (14%)

Query: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
           CP  C C  E  V   C    L  +P  IP ++  + L+ N IS + A            
Sbjct: 513 CPHKCRC--EANVV-ECSSLKLTKIPERIPQSTAELRLNNNEISILEATGM--------- 560

Query: 87  WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
                         F  L  L++++LS+N ++  ++   F G   +  LHL    L+ + 
Sbjct: 561 --------------FKKLTHLKKINLSNN-KVSEIEDGAFEGAASVSELHLTANQLESIR 605

Query: 147 PGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
            G+FRGL  L+ L L++N +  + +D+F  L N+  L L+ N+I++V   AF  L SL  
Sbjct: 606 SGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLST 665

Query: 207 LLLHQN 212
           L L  N
Sbjct: 666 LNLLAN 671



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 5/140 (3%)

Query: 27  CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTIL 86
           CP  C C +       C  + L+A+P GIP     ++L GN+ + VP       + L ++
Sbjct: 734 CPQECACLD---TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG-QLSTFKYLQLV 789

Query: 87  WLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELG 146
            L +N ++ +  ++FT ++ L  L LS NA L+ + P  F GL  L  L L    +  L 
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNA-LQCIPPLAFQGLRSLRLLSLHGNDISTLQ 848

Query: 147 PGLFRGLAALQYLYLQDNAL 166
            G+F  + +L +L +  N L
Sbjct: 849 EGIFADVTSLSHLAIGANPL 868



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 43/140 (30%), Positives = 66/140 (47%), Gaps = 5/140 (3%)

Query: 159 LYLQDNALQALPDD--TFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAH 216
           LYL  N    +P    TF+ L  +    L  N+ISS+   +F  +  L  L+L  N +  
Sbjct: 766 LYLDGNQFTLVPGQLSTFKYLQLVD---LSNNKISSLSNSSFTNMSQLTTLILSYNALQC 822

Query: 217 VHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQ 276
           + P AF+ L  L  L L  N++S L     A + +L +L +  NP  CDC  R L +W++
Sbjct: 823 IPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK 882

Query: 277 KFRGSSSEVPCSLPQRLAGR 296
                     C+ PQ + G+
Sbjct: 883 TGYKEPGIARCAGPQDMEGK 902


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  116 bits (290), Expect = 5e-26
 Identities = 86/267 (32%), Positives = 120/267 (44%), Gaps = 19/267 (7%)

Query: 11  LLAWVLWLQA------WQVAAPCPGACVCYNEP----------KVTTSCPQQGLQAVPVG 54
           LLAWV    A      W V  PCP  C C   P            T  C    L AVP  
Sbjct: 9   LLAWVAGATAAVPVVPWHV--PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPA 66

Query: 55  IPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSD 114
           +PA +Q + L  N I  V  +      NLT L L  N  +      F  L  L  L L +
Sbjct: 67  LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126

Query: 115 NAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTF 174
           N QL  ++  +F GL  L  L+L+   L  + P  F GL+ L  L+L  N L+A+    F
Sbjct: 127 N-QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185

Query: 175 RDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLF 234
             L NL  L + GN++ ++ +  FR L +L  L+L    +  +  +A   L  L +L  +
Sbjct: 186 EMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFY 245

Query: 235 ANNLSALPTEALAPLRALQYLRLNDNP 261
            N L+ +P  AL  +  L++L LN NP
Sbjct: 246 DNQLARVPRRALEQVPGLKFLDLNKNP 272


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  116 bits (290), Expect = 5e-26
 Identities = 86/267 (32%), Positives = 120/267 (44%), Gaps = 19/267 (7%)

Query: 11  LLAWVLWLQA------WQVAAPCPGACVCYNEP----------KVTTSCPQQGLQAVPVG 54
           LLAWV    A      W V  PCP  C C   P            T  C    L AVP  
Sbjct: 9   LLAWVAGATAAVPVVPWHV--PCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPA 66

Query: 55  IPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSD 114
           +PA +Q + L  N I  V  +      NLT L L  N  +      F  L  L  L L +
Sbjct: 67  LPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEE 126

Query: 115 NAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTF 174
           N QL  ++  +F GL  L  L+L+   L  + P  F GL+ L  L+L  N L+A+    F
Sbjct: 127 N-QLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185

Query: 175 RDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLF 234
             L NL  L + GN++ ++ +  FR L +L  L+L    +  +  +A   L  L +L  +
Sbjct: 186 EMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFY 245

Query: 235 ANNLSALPTEALAPLRALQYLRLNDNP 261
            N L+ +P  AL  +  L++L LN NP
Sbjct: 246 DNQLARVPRRALEQVPGLKFLDLNKNP 272


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  115 bits (289), Expect = 7e-26
 Identities = 84/260 (32%), Positives = 118/260 (45%), Gaps = 27/260 (10%)

Query: 27  CPGACVCYNEP-KVTTSCPQQGLQAVPVGIPAAS------------------------QR 61
           CP  C C  +   ++  C + GL AVP  +   +                        + 
Sbjct: 35  CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94

Query: 62  IFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSV 121
           + L GN +SH+P  +F    +L IL L +N L  I A A   L  L+ L L  N  +  V
Sbjct: 95  LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL-ISLV 153

Query: 122 DPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLT 181
              +F GL  L  L LD   L E+       L ALQ + L  N +  +PD  F++L +L 
Sbjct: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 213

Query: 182 HLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSAL 241
            L LH NRI  +   +F GLH+L+ L L+ N++    P A R LGRL  L    NN+ A+
Sbjct: 214 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAI 272

Query: 242 PTEALAPLRALQYLRLNDNP 261
           P +A      LQ +   DNP
Sbjct: 273 PEKAFMGNPLLQTIHFYDNP 292



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 67/187 (35%), Positives = 86/187 (45%), Gaps = 9/187 (4%)

Query: 54  GIPAAS-------QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLAL 106
           GIPA +       Q + L  N IS VP  SF    +L  LWL  N L  I   A   L  
Sbjct: 128 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 187

Query: 107 LEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNAL 166
           L+ + L+ N ++  +    F  L  L  LHL    +Q LG   F GL  L+ L L  N L
Sbjct: 188 LQAMTLALN-RISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246

Query: 167 QALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLG 226
           Q  P    R LG L  L  H N I ++PE+AF G   L  +  + N +  V   AF+ L 
Sbjct: 247 QEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 305

Query: 227 RLMTLYL 233
           +L TL L
Sbjct: 306 KLHTLSL 312



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 72/245 (29%), Positives = 99/245 (40%), Gaps = 52/245 (21%)

Query: 62  IFLHGNRISHVPAASFRACRNLTILWL-----------------------HSNVLARIDA 98
           + LH NRI H+   SF    NL  L L                       H+N +  I  
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 274

Query: 99  AAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLD-------------------- 138
            AF G  LL+ +   DN  ++ V  + F  L +LHTL L+                    
Sbjct: 275 KAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL 333

Query: 139 ---RCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPE 195
              R G++ L  G+ + L  L+ L L  N ++ LP  +      L  + L  NRI  +  
Sbjct: 334 TLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGA 391

Query: 196 RAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYL 255
             F  L SL  L L  N +  +HP AF  L  L+ L L  N L+ LP   LA L  L +L
Sbjct: 392 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHL 448

Query: 256 RLNDN 260
           +L  N
Sbjct: 449 KLKGN 453



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 1/73 (1%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + I L  NRI  + A +F    +L  L L  N +  I   AF+ L  L +LDL+DN QL 
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN-QLT 435

Query: 120 SVDPATFHGLGRL 132
           ++  A   GL  L
Sbjct: 436 TLPLAGLGGLMHL 448


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score =  114 bits (284), Expect = 3e-25
 Identities = 121/427 (28%), Positives = 168/427 (39%), Gaps = 65/427 (15%)

Query: 11  LLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRIS 70
           LL  +L L        CP  C C ++P+      +QG   VP  +P  +  +++  N I+
Sbjct: 8   LLPLLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGT-TVPRDVPPDTVGLYVFENGIT 65

Query: 71  HVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLG 130
            + A SF     L +L L  N +A + +  F  LA L  LDL+ N +L  +   TF GL 
Sbjct: 66  MLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTAN-RLHEITNETFRGLR 124

Query: 131 RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALP-------------------- 170
           RL  L+L +  ++ + PG F  L  L  L LQDN L+ALP                    
Sbjct: 125 RLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLAL 184

Query: 171 ------------------------DDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDR 206
                                   +  F  L NL  L +  N++  VP    RGL  L R
Sbjct: 185 EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIRGLRGLTR 243

Query: 207 LLLHQN-RVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCD 265
           L L  N R+A + P     L  L  L +   +L ALP +       L+ L    NP+ C 
Sbjct: 244 LRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCV 303

Query: 266 CRARPLWAWLQKFR---GSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTG 322
           C       W+++      S  E  C  P + AGR L  L   D  GC  AT     + T 
Sbjct: 304 CPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF-GCP-ATTTTATVPTT 361

Query: 323 RATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDS 382
           R    EP  L     P      + L P  PA+   +     PP  +PP  G  P+  +  
Sbjct: 362 RPVVREPTALSSSLAP------TWLSPTEPATEAPS-----PPSTAPPTVGPVPQPQDCP 410

Query: 383 PFGTLPG 389
           P   L G
Sbjct: 411 PSTCLNG 417


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  111 bits (277), Expect = 2e-24
 Identities = 74/202 (36%), Positives = 102/202 (50%), Gaps = 2/202 (0%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + + L GN +SH+P  +F    +L IL L +N L  I A A   L  L+ L L  N  + 
Sbjct: 41  EELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL-IS 99

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
            V   +F GL  L  L LD   L E+       L ALQ + L  N +  +PD  F++L +
Sbjct: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L LH NRI  +   +F GLH+L+ L L+ N++    P A R LGRL  L    NN+ 
Sbjct: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE-FPVAIRTLGRLQELGFHNNNIK 218

Query: 240 ALPTEALAPLRALQYLRLNDNP 261
           A+P +A      LQ +   DNP
Sbjct: 219 AIPEKAFMGNPLLQTIHFYDNP 240



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 70/194 (36%), Positives = 98/194 (50%), Gaps = 2/194 (1%)

Query: 67  NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126
           N ++ +    F   R L  L L  N L+ I   AF+GL  L+ L L +N QL  +     
Sbjct: 24  NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNN-QLGGIPAEAL 82

Query: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186
             L  L +L LD   +  +    F GL++L++L+L DNAL  +P     +L  L  + L 
Sbjct: 83  WELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLA 142

Query: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246
            NRIS +P+ AF+ L SL  L LH NR+ H+  H+F  L  L TL L  N L   P  A+
Sbjct: 143 LNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AI 201

Query: 247 APLRALQYLRLNDN 260
             L  LQ L  ++N
Sbjct: 202 RTLGRLQELGFHNN 215



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 55/155 (35%), Positives = 76/155 (49%), Gaps = 1/155 (0%)

Query: 106 LLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNA 165
           ++   DLS N  L  + P  FH L  L  L L    L  +    F GL +L+ L LQ+N 
Sbjct: 15  IISARDLSMN-NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73

Query: 166 LQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDL 225
           L  +P +   +L +L  L L  N IS VPER+F GL SL  L L  N +  +   A  +L
Sbjct: 74  LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 133

Query: 226 GRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
             L  + L  N +S +P  A   L +L  L L++N
Sbjct: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN 168



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 72/245 (29%), Positives = 99/245 (40%), Gaps = 52/245 (21%)

Query: 62  IFLHGNRISHVPAASFRACRNLTILWL-----------------------HSNVLARIDA 98
           + LH NRI H+   SF    NL  L L                       H+N +  I  
Sbjct: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 222

Query: 99  AAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLD-------------------- 138
            AF G  LL+ +   DN  ++ V  + F  L +LHTL L+                    
Sbjct: 223 KAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL 281

Query: 139 ---RCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPE 195
              R G++ L  G+ + L  L+ L L  N ++ LP  +      L  + L  NRI  +  
Sbjct: 282 TLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGA 339

Query: 196 RAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYL 255
             F  L SL  L L  N +  +HP AF  L  L+ L L  N L+ LP   LA L  L +L
Sbjct: 340 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHL 396

Query: 256 RLNDN 260
           +L  N
Sbjct: 397 KLKGN 401



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 63/204 (30%), Positives = 96/204 (47%), Gaps = 10/204 (4%)

Query: 41  TSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAA 100
           T  P + L  +P     A Q + L  NRISH+P  +F+   +L +L LH+N +  +   +
Sbjct: 123 TEIPVRALNNLP-----ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS 177

Query: 101 FTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLY 160
           F GL  LE LDL+ N +L+   P     LGRL  L      ++ +    F G   LQ ++
Sbjct: 178 FEGLHNLETLDLNYN-KLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 235

Query: 161 LQDNALQALPDDTFRDLGNLTHLFLHGNR-ISSVPERAFRGLHSLDRLLLHQNRVAHVHP 219
             DN +Q +    F+ L  L  L L+G   I   P+   +G  SL+ L L +  +  +  
Sbjct: 236 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPS 293

Query: 220 HAFRDLGRLMTLYLFANNLSALPT 243
              + L RL  L L  N +  LP+
Sbjct: 294 GMCQQLPRLRVLELSHNQIEELPS 317



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 1/73 (1%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + I L  NRI  + A +F    +L  L L  N +  I   AF+ L  L +LDL+DN QL 
Sbjct: 325 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN-QLT 383

Query: 120 SVDPATFHGLGRL 132
           ++  A   GL  L
Sbjct: 384 TLPLAGLGGLMHL 396


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  110 bits (276), Expect = 2e-24
 Identities = 79/264 (29%), Positives = 121/264 (45%), Gaps = 25/264 (9%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           + ++L  N++S VP   F    ++  L L  N L  + +  F G+  L  LDLS+N  LR
Sbjct: 135 RNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR 194

Query: 120 -----------------------SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAAL 156
                                   V    F  L  L  L L    ++ + P  F+GLA L
Sbjct: 195 ISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANL 254

Query: 157 QYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAH 216
           +YL L+++ ++ +  D F  + NL HL L  N + ++    F  L +L  L L +NR+  
Sbjct: 255 EYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIIS 314

Query: 217 VHPHAFRDLG-RLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWL 275
           +    F ++G  L  L L  NNL+AL    L PL +L +L+ N NPW C+C+   L  WL
Sbjct: 315 IDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWL 374

Query: 276 QKFRGSSSEVPCSLPQRLAGRDLK 299
                 +  + C  P  + GR L+
Sbjct: 375 AS-SAITLNIYCQNPPSMRGRALR 397



 Score =  101 bits (252), Expect = 1e-21
 Identities = 65/220 (29%), Positives = 107/220 (48%), Gaps = 25/220 (11%)

Query: 42  SCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAF 101
           +C   GL ++P   P ++  ++L GN IS++  +      +L  L+L             
Sbjct: 45  NCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYL------------- 91

Query: 102 TGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYL 161
                       DN+ +  V P  F  L  L+ L L+   ++ L PG+F+GL  L+ LYL
Sbjct: 92  ------------DNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYL 139

Query: 162 QDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHA 221
           Q N +  +P   F DL ++ +L L  NR++ +    F G+ +L  L L  N +  +    
Sbjct: 140 QYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESG 199

Query: 222 FRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNP 261
           F+ L  L  LYL +NNL+ +P+ A   L++L+ L L+ NP
Sbjct: 200 FQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  110 bits (274), Expect = 4e-24
 Identities = 89/290 (30%), Positives = 124/290 (42%), Gaps = 28/290 (9%)

Query: 53  VGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDL 112
           +G  A  +R+ LH NR+  + +    +   LT L  H N +  I   AF  L  L  L L
Sbjct: 190 LGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTL 249

Query: 113 SDNA-----------------------QLRSVDPATFHGLGRLHTLHLDRCGLQELGPGL 149
           S N                         L  +    F  +G L  L L+R  L+ L    
Sbjct: 250 SRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAA 309

Query: 150 FRGLAALQYLYLQ-DNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLL 208
           FR L+ L+YL +     L ALP   F+ LG L  L LH N ++++P+   RGL  L ++ 
Sbjct: 310 FRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVS 369

Query: 209 LHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRA 268
           L +NR+  +    FR+L  L ++ L  N L  LP +    L  L  + L  N W CDC  
Sbjct: 370 LRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGL 429

Query: 269 RPLWAWLQKFRG--SSSEVP-CSLPQRLAGRDLKRLAANDLQGCAVATGP 315
            P   WL++  G     E P C+ P   AG  L  L   D + C    GP
Sbjct: 430 GPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAE-CPGPRGP 478



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 67/202 (33%), Positives = 89/202 (44%), Gaps = 1/202 (0%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           QR+ +  + IS V   +F     L  L L  N +  +  A    + LLEQL L  NA LR
Sbjct: 77  QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNA-LR 135

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
            +D   F  L  L  L L++  L  L   LF  L  L+ L L  N L  LP         
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAK 195

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L LH NR+ S+       L +L  L  H+N +  + P AF  L  L +L L  N+L+
Sbjct: 196 LERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLA 255

Query: 240 ALPTEALAPLRALQYLRLNDNP 261
            LP+        L  L L +NP
Sbjct: 256 FLPSALFLHSHNLTLLTLFENP 277



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 4/216 (1%)

Query: 48  LQAVPVGIPAASQRIFLHGNRISHVPAASFRAC---RNLTILWLHSNVLARIDAAAFTGL 104
           L+A P   P A + +F    + S    A   A     NLT + L       + + +F+G+
Sbjct: 14  LRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGM 73

Query: 105 ALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
            +L++L +SD + + +V P TF  L +L TL L R  +  L   L   +  L+ L+L  N
Sbjct: 74  TVLQRLMISD-SHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHN 132

Query: 165 ALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRD 224
           AL+ +  + F+ L NL  L L+ N++  +P   F  L +L  L L  N + H+       
Sbjct: 133 ALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGA 192

Query: 225 LGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
             +L  L L +N L +L +  L  L AL  L+ + N
Sbjct: 193 QAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRN 228


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  109 bits (273), Expect = 5e-24
 Identities = 92/322 (28%), Positives = 137/322 (42%), Gaps = 51/322 (15%)

Query: 25  APCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLT 84
           A CP  C C+++ +    C + GLQ +P  +   ++ + L  N    + A SFRA  NL 
Sbjct: 21  AACPQNCHCHSDLQHVI-CDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLV 78

Query: 85  ILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQE 144
            L L    +  + A AF GL  L  L LS N  +R +    F  L  L  L+LD   + E
Sbjct: 79  SLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DIRVLRAGAFDDLTELTYLYLDHNKVTE 137

Query: 145 LGPGL------------------------FRGLAALQYLYLQDNALQALPDDTFRDLGNL 180
           L  GL                        F+G   L++LYL +NAL +L      D+ NL
Sbjct: 138 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197

Query: 181 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGR-LMTLYLFANNLS 239
               +  N++SS P  A   L  ++ L L  N +  +  +AF+  GR L TL+L   NL 
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257

Query: 240 ALPTEALA----------------------PLRALQYLRLNDNPWVCDCRARPLWAWLQK 277
                A                        P  +L+ L L +NPW C C+ R L  WL+ 
Sbjct: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLEA 317

Query: 278 FRGSSSEVPCSLPQRLAGRDLK 299
            + S  +  C+ P +  G+ ++
Sbjct: 318 -KASRPDATCASPAKFKGQHIR 338


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  109 bits (272), Expect = 6e-24
 Identities = 83/236 (35%), Positives = 111/236 (47%), Gaps = 4/236 (1%)

Query: 27  CPGACVCYNEPKVT--TSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLT 84
           CP  C C  + ++     C   GL  +P  +   +  + L  N IS +      + R L 
Sbjct: 34  CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93

Query: 85  ILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQE 144
            L L  N L  I   AFTGL  L+ L L +N QLR V       L  L +L LD   +  
Sbjct: 94  ELRLAGNALTYIPKGAFTGLYSLKVLMLQNN-QLRHVPTEALQNLRSLQSLRLDANHISY 152

Query: 145 LGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSL 204
           + P  F GL +L++L+L DNAL  +P   FR L  L  + L  N+I  +P+ AF  L SL
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212

Query: 205 DRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
             L LH NR+  +    F  L  L TL L  NNL   PT A+  L  L+ L  + N
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSN 267



 Score =  109 bits (272), Expect = 6e-24
 Identities = 73/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 49  QAVPVGIPAAS--QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLAL 106
           Q +P  +P+    + + L GN ++++P  +F    +L +L L +N L  +   A   L  
Sbjct: 80  QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRS 139

Query: 107 LEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNAL 166
           L+ L L  N  +  V P+ F GL  L  L LD   L E+    FR L+ALQ + L  N +
Sbjct: 140 LQSLRLDAN-HISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198

Query: 167 QALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLG 226
             +PD  F +L +L  L LH NRI S+ ++ F GLHSL+ L L+ N +    P A R L 
Sbjct: 199 HHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLS 257

Query: 227 RLMTLYLFANNLSALPTEALAPLRALQYLRLNDNP 261
            L  L   +NN+ ++P +A     +L  +   DNP
Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/174 (36%), Positives = 83/174 (47%), Gaps = 2/174 (1%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           Q + L  N IS+VP + F    +L  LWL  N L  I   AF  L+ L+ + L+ N ++ 
Sbjct: 141 QSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN-KIH 199

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
            +    F  L  L  LHL    +  LG   F GL +L+ L L  N L   P    R L N
Sbjct: 200 HIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSN 258

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYL 233
           L  L  H N I S+PE+AF G  SL  +  + N +  V   AF+ L  L TL L
Sbjct: 259 LKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL 312



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 63/215 (29%), Positives = 94/215 (43%), Gaps = 9/215 (4%)

Query: 48  LQAVPVGIPAAS--QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLA 105
           L   P  I   S  + +  H N I  +P  +F    +L  +  + N +  +  +AF  L 
Sbjct: 246 LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305

Query: 106 LLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNA 165
            L  L L+  +Q+      T  G   L +L L    +  L   +   L  LQ L L  N 
Sbjct: 306 ELRTLTLNGASQITEFPDLT--GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNL 363

Query: 166 LQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDL 225
           L+ LP  +F     L  + L  N I  +    F+ L SL  L L  N++A +HP+AF  L
Sbjct: 364 LEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTL 421

Query: 226 GRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
             L+ L L +N LS+ P   +  L  L +L+L  N
Sbjct: 422 PSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  108 bits (270), Expect = 1e-23
 Identities = 75/216 (34%), Positives = 105/216 (48%), Gaps = 4/216 (1%)

Query: 48  LQAVPVGIPA---ASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGL 104
           LQ +P+G+     + + + L  N++  +  A F  C NL  L LH N L  I   AF  L
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 178

Query: 105 ALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
             L +L+L  N+ L  + P  F  LG L  L L    L ++  G F GL  LQ L LQ N
Sbjct: 179 VGLTKLNLGKNS-LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 237

Query: 165 ALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRD 224
            +  L    F +  NL  L+L  N IS +P   F  L  L+RL L  N +  +    F  
Sbjct: 238 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 297

Query: 225 LGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
           +  L  L+L+ N++S+LP    + LR LQ L L+ N
Sbjct: 298 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333



 Score =  107 bits (267), Expect = 2e-23
 Identities = 83/266 (31%), Positives = 119/266 (44%), Gaps = 28/266 (10%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           Q + L+ NR++ +P  +F    NL  L L  N +  +    F     L++L LS+N  + 
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-HIS 264

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
            + P+ F  L +L+ L L    L+EL  G+F  +  L+ L+L DN + +LPD+ F +L  
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L L  N+IS +   AF GL  L  L LH N +  +  + FR L  L  + L  N L 
Sbjct: 325 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 384

Query: 240 ALPTEALAPLRALQ------------------------YLRLNDNPWVCDCRARPLWAWL 275
            LP    A +  L                          LRL DNPW CD    PL  WL
Sbjct: 385 QLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444

Query: 276 ---QKFRGSSSEVPCSLPQRLAGRDL 298
              Q   G+ +   C  P  + G+ L
Sbjct: 445 LLNQPRLGTDTVPVCFSPANVRGQSL 470



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 74/245 (30%), Positives = 100/245 (40%), Gaps = 30/245 (12%)

Query: 19  QAWQVAAP---CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAA 75
           QAW        CP  C C    +V   C    + AVP  +P  +  + +    I+ +  +
Sbjct: 20  QAWGAGLAYHGCPSECTCSRASQV--ECTGARIVAVPTPLPWNAMSLQILNTHITELNES 77

Query: 76  SFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTL 135
            F     L  L +  N L+RI                          P  F  LG L  L
Sbjct: 78  PFLNISALIALRIEKNELSRIT-------------------------PGAFRNLGSLRYL 112

Query: 136 HLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPE 195
            L    LQ L  GLF+GL +L+ L L  N L  +    F    NL  L LHGN +  +P+
Sbjct: 113 SLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPD 172

Query: 196 RAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYL 255
            AF  L  L +L L +N + H+ P  F+ LG L  L L+ N L+ +P      L  LQ L
Sbjct: 173 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQEL 232

Query: 256 RLNDN 260
            L  N
Sbjct: 233 ALQQN 237


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  108 bits (270), Expect = 1e-23
 Identities = 75/216 (34%), Positives = 105/216 (48%), Gaps = 4/216 (1%)

Query: 48  LQAVPVGIPA---ASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGL 104
           LQ +P+G+     + + + L  N++  +  A F  C NL  L LH N L  I   AF  L
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 172

Query: 105 ALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDN 164
             L +L+L  N+ L  + P  F  LG L  L L    L ++  G F GL  LQ L LQ N
Sbjct: 173 VGLTKLNLGKNS-LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 231

Query: 165 ALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRD 224
            +  L    F +  NL  L+L  N IS +P   F  L  L+RL L  N +  +    F  
Sbjct: 232 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 291

Query: 225 LGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
           +  L  L+L+ N++S+LP    + LR LQ L L+ N
Sbjct: 292 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327



 Score =  107 bits (267), Expect = 2e-23
 Identities = 83/266 (31%), Positives = 119/266 (44%), Gaps = 28/266 (10%)

Query: 60  QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
           Q + L+ NR++ +P  +F    NL  L L  N +  +    F     L++L LS+N  + 
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-HIS 258

Query: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
            + P+ F  L +L+ L L    L+EL  G+F  +  L+ L+L DN + +LPD+ F +L  
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318

Query: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
           L  L L  N+IS +   AF GL  L  L LH N +  +  + FR L  L  + L  N L 
Sbjct: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 378

Query: 240 ALPTEALAPLRALQ------------------------YLRLNDNPWVCDCRARPLWAWL 275
            LP    A +  L                          LRL DNPW CD    PL  WL
Sbjct: 379 QLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438

Query: 276 ---QKFRGSSSEVPCSLPQRLAGRDL 298
              Q   G+ +   C  P  + G+ L
Sbjct: 439 LLNQPRLGTDTVPVCFSPANVRGQSL 464



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 74/245 (30%), Positives = 100/245 (40%), Gaps = 30/245 (12%)

Query: 19  QAWQVAAP---CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAA 75
           QAW        CP  C C    +V   C    + AVP  +P  +  + +    I+ +  +
Sbjct: 14  QAWGAGLAYHGCPSECTCSRASQV--ECTGARIVAVPTPLPWNAMSLQILNTHITELNES 71

Query: 76  SFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTL 135
            F     L  L +  N L+RI                          P  F  LG L  L
Sbjct: 72  PFLNISALIALRIEKNELSRIT-------------------------PGAFRNLGSLRYL 106

Query: 136 HLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPE 195
            L    LQ L  GLF+GL +L+ L L  N L  +    F    NL  L LHGN +  +P+
Sbjct: 107 SLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPD 166

Query: 196 RAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYL 255
            AF  L  L +L L +N + H+ P  F+ LG L  L L+ N L+ +P      L  LQ L
Sbjct: 167 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQEL 226

Query: 256 RLNDN 260
            L  N
Sbjct: 227 ALQQN 231


>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score =  105 bits (263), Expect = 7e-23
 Identities = 75/214 (35%), Positives = 107/214 (50%), Gaps = 10/214 (4%)

Query: 101 FTGLALLE-------QLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL 153
           FT ++LL+       QL L+ N   R + P  F       TLHL   GLQE+  G F GL
Sbjct: 51  FTTVSLLQPPQYRIYQLFLNGNLLTR-LYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGL 109

Query: 154 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR 213
             L+ L+L +N L+ L +DTF  L +L +L    N IS++   AF  L+ L  L+L+ N 
Sbjct: 110 KTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNL 169

Query: 214 VAHVHPHAFRDLGRLMTLYLFANNLSALP-TEALAPLRALQYLRLNDNPWVCDCRARPLW 272
           +  +  + FR +  L  L L  N L  +P    L  +  +  ++L +NPW C C   PL 
Sbjct: 170 LLSLPSNVFRFV-LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLK 228

Query: 273 AWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306
           AWL        E+ C  P RL G+D+ +L   DL
Sbjct: 229 AWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL 262



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 80/287 (27%), Positives = 119/287 (41%), Gaps = 58/287 (20%)

Query: 23  VAAPCPGACVCYNEPK---VTTSCPQQGLQAVP--VGIPAASQRIFLHGNRISHVPAASF 77
           V   CP +CVC ++     +  +C ++    +      P + ++++L GN +  V     
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 78  RACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHL 137
               +L +L L +N +A I   AFT L  L +L L+ N                      
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNY--------------------- 434

Query: 138 DRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERA 197
               L+ L P +F GL +LQYLYL+ N ++ +   TF  L NL  LFL+ N + S+P+  
Sbjct: 435 ----LEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490

Query: 198 FRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE-ALAPLRALQYLR 256
           F G  +L RL L  N  +H                        LP +  L  L A   + 
Sbjct: 491 FGGT-ALTRLNLRNNHFSH------------------------LPVKGVLDQLPAFIQID 525

Query: 257 LNDNPWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
           L +NPW C C    L  W +        +EV C  P + AG  LK L
Sbjct: 526 LQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572


>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score =  105 bits (263), Expect = 7e-23
 Identities = 75/214 (35%), Positives = 107/214 (50%), Gaps = 10/214 (4%)

Query: 101 FTGLALLE-------QLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL 153
           FT ++LL+       QL L+ N   R + P  F       TLHL   GLQE+  G F GL
Sbjct: 51  FTTVSLLQPPQYRIYQLFLNGNLLTR-LYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGL 109

Query: 154 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR 213
             L+ L+L +N L+ L +DTF  L +L +L    N IS++   AF  L+ L  L+L+ N 
Sbjct: 110 KTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNL 169

Query: 214 VAHVHPHAFRDLGRLMTLYLFANNLSALP-TEALAPLRALQYLRLNDNPWVCDCRARPLW 272
           +  +  + FR +  L  L L  N L  +P    L  +  +  ++L +NPW C C   PL 
Sbjct: 170 LLSLPSNVFRFV-LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLK 228

Query: 273 AWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306
           AWL        E+ C  P RL G+D+ +L   DL
Sbjct: 229 AWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL 262



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 80/287 (27%), Positives = 119/287 (41%), Gaps = 58/287 (20%)

Query: 23  VAAPCPGACVCYNEPK---VTTSCPQQGLQAVP--VGIPAASQRIFLHGNRISHVPAASF 77
           V   CP +CVC ++     +  +C ++    +      P + ++++L GN +  V     
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 78  RACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHL 137
               +L +L L +N +A I   AFT L  L +L L+ N                      
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNY--------------------- 434

Query: 138 DRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERA 197
               L+ L P +F GL +LQYLYL+ N ++ +   TF  L NL  LFL+ N + S+P+  
Sbjct: 435 ----LEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490

Query: 198 FRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE-ALAPLRALQYLR 256
           F G  +L RL L  N  +H                        LP +  L  L A   + 
Sbjct: 491 FGGT-ALTRLNLRNNHFSH------------------------LPVKGVLDQLPAFIQID 525

Query: 257 LNDNPWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
           L +NPW C C    L  W +        +EV C  P + AG  LK L
Sbjct: 526 LQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572


>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score =  105 bits (263), Expect = 7e-23
 Identities = 75/214 (35%), Positives = 107/214 (50%), Gaps = 10/214 (4%)

Query: 101 FTGLALLE-------QLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL 153
           FT ++LL+       QL L+ N   R + P  F       TLHL   GLQE+  G F GL
Sbjct: 51  FTTVSLLQPPQYRIYQLFLNGNLLTR-LYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGL 109

Query: 154 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR 213
             L+ L+L +N L+ L +DTF  L +L +L    N IS++   AF  L+ L  L+L+ N 
Sbjct: 110 KTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNL 169

Query: 214 VAHVHPHAFRDLGRLMTLYLFANNLSALP-TEALAPLRALQYLRLNDNPWVCDCRARPLW 272
           +  +  + FR +  L  L L  N L  +P    L  +  +  ++L +NPW C C   PL 
Sbjct: 170 LLSLPSNVFRFV-LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLK 228

Query: 273 AWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306
           AWL        E+ C  P RL G+D+ +L   DL
Sbjct: 229 AWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL 262



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 80/287 (27%), Positives = 119/287 (41%), Gaps = 58/287 (20%)

Query: 23  VAAPCPGACVCYNEPK---VTTSCPQQGLQAVP--VGIPAASQRIFLHGNRISHVPAASF 77
           V   CP +CVC ++     +  +C ++    +      P + ++++L GN +  V     
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 78  RACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHL 137
               +L +L L +N +A I   AFT L  L +L L+ N                      
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNY--------------------- 434

Query: 138 DRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERA 197
               L+ L P +F GL +LQYLYL+ N ++ +   TF  L NL  LFL+ N + S+P+  
Sbjct: 435 ----LEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490

Query: 198 FRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE-ALAPLRALQYLR 256
           F G  +L RL L  N  +H                        LP +  L  L A   + 
Sbjct: 491 FGGT-ALTRLNLRNNHFSH------------------------LPVKGVLDQLPAFIQID 525

Query: 257 LNDNPWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
           L +NPW C C    L  W +        +EV C  P + AG  LK L
Sbjct: 526 LQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572


>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score =  105 bits (263), Expect = 7e-23
 Identities = 75/214 (35%), Positives = 107/214 (50%), Gaps = 10/214 (4%)

Query: 101 FTGLALLE-------QLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL 153
           FT ++LL+       QL L+ N   R + P  F       TLHL   GLQE+  G F GL
Sbjct: 51  FTTVSLLQPPQYRIYQLFLNGNLLTR-LYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGL 109

Query: 154 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR 213
             L+ L+L +N L+ L +DTF  L +L +L    N IS++   AF  L+ L  L+L+ N 
Sbjct: 110 KTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNL 169

Query: 214 VAHVHPHAFRDLGRLMTLYLFANNLSALP-TEALAPLRALQYLRLNDNPWVCDCRARPLW 272
           +  +  + FR +  L  L L  N L  +P    L  +  +  ++L +NPW C C   PL 
Sbjct: 170 LLSLPSNVFRFV-LLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLK 228

Query: 273 AWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDL 306
           AWL        E+ C  P RL G+D+ +L   DL
Sbjct: 229 AWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDL 262



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 80/287 (27%), Positives = 119/287 (41%), Gaps = 58/287 (20%)

Query: 23  VAAPCPGACVCYNEPK---VTTSCPQQGLQAVP--VGIPAASQRIFLHGNRISHVPAASF 77
           V   CP +CVC ++     +  +C ++    +      P + ++++L GN +  V     
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 78  RACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHL 137
               +L +L L +N +A I   AFT L  L +L L+ N                      
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNY--------------------- 434

Query: 138 DRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERA 197
               L+ L P +F GL +LQYLYL+ N ++ +   TF  L NL  LFL+ N + S+P+  
Sbjct: 435 ----LEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490

Query: 198 FRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE-ALAPLRALQYLR 256
           F G  +L RL L  N  +H                        LP +  L  L A   + 
Sbjct: 491 FGGT-ALTRLNLRNNHFSH------------------------LPVKGVLDQLPAFIQID 525

Query: 257 LNDNPWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
           L +NPW C C    L  W +        +EV C  P + AG  LK L
Sbjct: 526 LQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFL 572


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,529,029
Number of Sequences: 37866
Number of extensions: 1309104
Number of successful extensions: 9991
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 499
Number of HSP's that attempted gapping in prelim test: 6714
Number of HSP's gapped (non-prelim): 2028
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.