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Search of human proteins with 4557529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 1535 0.0
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 1420 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1062 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1054 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 978 0.0
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 964 0.0
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 963 0.0
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 958 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 590 e-168
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 447 e-125
gi|95089461 discs large homolog 5 [Homo sapiens] 192 1e-48
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 189 6e-48
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 165 1e-40
gi|45827729 scribble isoform b [Homo sapiens] 161 2e-39
gi|45827731 scribble isoform a [Homo sapiens] 161 2e-39
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 155 1e-37
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 152 1e-36
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 150 6e-36
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 150 6e-36
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 148 2e-35
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 147 4e-35
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 147 5e-35
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 138 2e-32
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 138 2e-32
gi|112382257 InaD-like [Homo sapiens] 135 1e-31
gi|148746189 multiple PDZ domain protein [Homo sapiens] 129 1e-29
gi|10092691 tight junction protein 3 [Homo sapiens] 127 3e-29
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 125 1e-28
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 125 1e-28
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 117 5e-26
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 1535 bits (3974), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDE 60
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDE
Sbjct: 1 MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDE 60
Query: 61 DTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGF 120
DTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGF
Sbjct: 61 DTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGF 120
Query: 121 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 180
SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
Sbjct: 121 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 180
Query: 181 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG
Sbjct: 181 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240
Query: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP
Sbjct: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
Query: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH
Sbjct: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
Query: 361 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI
Sbjct: 361 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 421 ALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALF 480
ALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALF
Sbjct: 421 ALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALF 480
Query: 481 DYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR 540
DYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR
Sbjct: 481 DYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR 540
Query: 541 EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPD 600
EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPD
Sbjct: 541 EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPD 600
Query: 601 KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVR 660
KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVR
Sbjct: 601 KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVR 660
Query: 661 EVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRA 720
EVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRA
Sbjct: 661 EVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRA 720
Query: 721 TKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
TKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
Sbjct: 721 TKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 1420 bits (3675), Expect = 0.0
Identities = 711/716 (99%), Positives = 713/716 (99%), Gaps = 3/716 (0%)
Query: 52 SQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITL 111
++KYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGY VNGTEGEMEYEEITL
Sbjct: 9 TKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGY---VNGTEGEMEYEEITL 65
Query: 112 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171
ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV
Sbjct: 66 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125
Query: 172 THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 231
THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS
Sbjct: 126 THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 185
Query: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN
Sbjct: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
Query: 292 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 351
AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP
Sbjct: 246 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 305
Query: 352 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR
Sbjct: 306 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
Query: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK
Sbjct: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
Query: 472 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 531
RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI
Sbjct: 426 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 485
Query: 532 PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 591
PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN
Sbjct: 486 PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 545
Query: 592 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 651
DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL
Sbjct: 546 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 605
Query: 652 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 711
YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE
Sbjct: 606 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 665
Query: 712 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
Sbjct: 666 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1062 bits (2747), Expect = 0.0
Identities = 530/720 (73%), Positives = 615/720 (85%), Gaps = 36/720 (5%)
Query: 75 QANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDD 134
QAN PPV+VNTD+LE P Y VNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD
Sbjct: 194 QANPPPVLVNTDSLETPTY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDD 250
Query: 135 PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194
SIFITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RR
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
KP +EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
+LAVN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNH 430
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE 374
+S SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGE
Sbjct: 431 VSPSSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE 484
Query: 375 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
DGEGIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQ
Sbjct: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Query: 435 YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQA 494
Y+PEEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ
Sbjct: 545 YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQG 604
Query: 495 LSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KA 547
L+F+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K
Sbjct: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
Query: 548 KDWG--------------------SSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTK 587
+D G S S +G+E+ VLSYE V Q EV+Y RP+IILGP K
Sbjct: 665 RDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMK 724
Query: 588 DRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQY 647
DR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV+SRE+MEKDIQ HKFIEAGQY
Sbjct: 725 DRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQY 784
Query: 648 NSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR 707
N+HLYGTSVQSVREVAE+GKHCILDVS NA++RLQ A L+PI+IFI+P+S+EN++E+NKR
Sbjct: 785 NNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR 844
Query: 708 ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
+TEEQARK F+RA KLEQEFTE F+AIV+GD+ E+IY++VK++IE+ SG YIWVPA+E+L
Sbjct: 845 LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
Score = 140 bits (352), Expect = 6e-33
Identities = 119/453 (26%), Positives = 183/453 (40%), Gaps = 140/453 (30%)
Query: 26 LLTVLHSDLFQALLDILDYYEASLSES--------------------------------- 52
++ + S+LFQAL+DI ++YE +L ++
Sbjct: 37 VINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSET 96
Query: 53 ---------QKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYELQVNGTEG 102
+KYRYQDEDTPP EH + N+ P ++ V+ L ++ G
Sbjct: 97 LPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLS------EIENVHG 150
Query: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
+ + I+ + + + P++ + ++P A
Sbjct: 151 FVSHSHISPIKPTEAV------------LPSPPTVPVIPVLPVPAE-------------- 184
Query: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVG 222
N V + + + L S+ + + EI L +G GLGFSIAGG
Sbjct: 185 -NTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTD 243
Query: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
N HI D+SI++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V
Sbjct: 244 NPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIV 303
Query: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342
L V +R PV++
Sbjct: 304 RLYV------------------------------------------------KRRKPVSE 315
Query: 343 DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGEL 396
++ I + +G GLGF+I GG + I+++ I+ GG A G+L
Sbjct: 316 KIM----------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 397 RKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
+ GD++L+VN V L +HE+A ALKN V
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1054 bits (2725), Expect = 0.0
Identities = 530/742 (71%), Positives = 615/742 (82%), Gaps = 58/742 (7%)
Query: 75 QANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDD 134
QAN PPV+VNTD+LE P Y VNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD
Sbjct: 194 QANPPPVLVNTDSLETPTY---VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDD 250
Query: 135 PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194
SIFITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RR
Sbjct: 251 SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR 310
Query: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
KP +EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK
Sbjct: 311 KPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
+LAVN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNH 430
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE 374
+S SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGE
Sbjct: 431 VSPSSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE 484
Query: 375 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
DGEGIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQ
Sbjct: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ 544
Query: 435 YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQA 494
Y+PEEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ
Sbjct: 545 YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQG 604
Query: 495 LSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KA 547
L+F+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K
Sbjct: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
Query: 548 KDWG------------------------------------------SSSGSQGREDSVLS 565
+D G S S +G+E+ VLS
Sbjct: 665 RDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLS 724
Query: 566 YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHF 625
YE V Q EV+Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHF
Sbjct: 725 YEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHF 784
Query: 626 VSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAH 685
V+SRE+MEKDIQ HKFIEAGQYN+HLYGTSVQSVREVAE+GKHCILDVS NA++RLQ A
Sbjct: 785 VTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQ 844
Query: 686 LHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYH 745
L+PI+IFI+P+S+EN++E+NKR+TEEQARK F+RA KLEQEFTE F+AIV+GD+ E+IY+
Sbjct: 845 LYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYN 904
Query: 746 KVKRVIEDLSGPYIWVPARERL 767
+VK++IE+ SG YIWVPA+E+L
Sbjct: 905 QVKQIIEEQSGSYIWVPAKEKL 926
Score = 140 bits (352), Expect = 6e-33
Identities = 119/453 (26%), Positives = 183/453 (40%), Gaps = 140/453 (30%)
Query: 26 LLTVLHSDLFQALLDILDYYEASLSES--------------------------------- 52
++ + S+LFQAL+DI ++YE +L ++
Sbjct: 37 VINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSET 96
Query: 53 ---------QKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYELQVNGTEG 102
+KYRYQDEDTPP EH + N+ P ++ V+ L ++ G
Sbjct: 97 LPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLS------EIENVHG 150
Query: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
+ + I+ + + + P++ + ++P A
Sbjct: 151 FVSHSHISPIKPTEAV------------LPSPPTVPVIPVLPVPAE-------------- 184
Query: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVG 222
N V + + + L S+ + + EI L +G GLGFSIAGG
Sbjct: 185 -NTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTD 243
Query: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
N HI D+SI++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V
Sbjct: 244 NPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIV 303
Query: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342
L V +R PV++
Sbjct: 304 RLYV------------------------------------------------KRRKPVSE 315
Query: 343 DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGEL 396
++ I + +G GLGF+I GG + I+++ I+ GG A G+L
Sbjct: 316 KIM----------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 397 RKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
+ GD++L+VN V L +HE+A ALKN V
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 978 bits (2529), Expect = 0.0
Identities = 484/716 (67%), Positives = 581/716 (81%), Gaps = 43/716 (6%)
Query: 95 LQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRL 154
+ VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKIIPGGAAA+DGRL
Sbjct: 34 IPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRL 93
Query: 155 RVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG 214
RVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E V+EIKL KGPKGLG
Sbjct: 94 RVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLG 153
Query: 215 FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAA 274
FSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+ LE+V HE+AVA
Sbjct: 154 FSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAI 213
Query: 275 LKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSP 334
LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + + +Y T++ P SP
Sbjct: 214 LKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP 273
Query: 335 RRYSPVAKDLLGEED-----------------------IPREPRRIVIHRGSTGLGFNIV 371
RYSP+ K +L ++D + EPR++V+H+GSTGLGFNIV
Sbjct: 274 GRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333
Query: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
GGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQTVTI
Sbjct: 334 GGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Query: 432 IAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFL 491
IAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD G
Sbjct: 394 IAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLP 453
Query: 492 SQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWG 551
SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RLK +
Sbjct: 454 SQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFN 513
Query: 552 SSSG--------------------SQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 591
+ G +G+ED +LSYE VT+ E++Y RP+IILGP KDR N
Sbjct: 514 AKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN 573
Query: 592 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 651
DDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +L
Sbjct: 574 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL 633
Query: 652 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 711
YGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEE
Sbjct: 634 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE 693
Query: 712 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
QA+K +DRA KLEQEF E F+AIV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 694 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 964 bits (2493), Expect = 0.0
Identities = 509/869 (58%), Positives = 610/869 (70%), Gaps = 150/869 (17%)
Query: 45 YEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSP------------------------- 79
Y A + +KYRYQDED P +HS L ++ P
Sbjct: 6 YCALRTNVKKYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHI 64
Query: 80 --------PVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHI 131
P+IVNTDTL+ Y VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHI
Sbjct: 65 SPLKASPAPIIVNTDTLDTIPY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHI 121
Query: 132 GDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYV 191
GDDP IFITKIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV
Sbjct: 122 GDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181
Query: 192 MRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQI 251
RR+P E V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+
Sbjct: 182 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 241
Query: 252 GDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL 311
GD++L VN+ LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS +
Sbjct: 242 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 301
Query: 312 DNEISHSSYLGTDYPTAMTP-------------------------------------TSP 334
+N + + +Y T++ P SP
Sbjct: 302 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 361
Query: 335 RRYSPVAKD---------------LLGEEDIPR-----------------------EPRR 356
R YSPV D LL + ++ EPR+
Sbjct: 362 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 421
Query: 357 IVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 416
+V+H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHE
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 417 QAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYI 476
QAA ALK AGQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+
Sbjct: 482 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 541
Query: 477 RALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRR 536
RA+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRR
Sbjct: 542 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRR 601
Query: 537 VERREWSRLKAKDWGSSSG--------------------------------------SQG 558
VER+E +RLK + + G +G
Sbjct: 602 VERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERG 661
Query: 559 REDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEI 618
+ED +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+
Sbjct: 662 QEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV 721
Query: 619 DGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAV 678
DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA+
Sbjct: 722 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 781
Query: 679 RRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGD 738
+RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD
Sbjct: 782 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 841
Query: 739 SFEEIYHKVKRVIEDLSGPYIWVPARERL 767
+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 842 TLEDIYNQCKLVIEEQSGPFIWIPSKEKL 870
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 963 bits (2490), Expect = 0.0
Identities = 507/860 (58%), Positives = 606/860 (70%), Gaps = 150/860 (17%)
Query: 54 KYRYQDEDTPPLEHSPAHLPNQANSP---------------------------------P 80
KYRYQDED P +HS L ++ P P
Sbjct: 120 KYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
Query: 81 VIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFIT 140
+IVNTDTL+ Y VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFIT
Sbjct: 179 IIVNTDTLDTIPY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235
Query: 141 KIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEK 200
KIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E
Sbjct: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILET 295
Query: 201 VMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 260
V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+
Sbjct: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
Query: 261 VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSY 320
LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + +
Sbjct: 356 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415
Query: 321 LGTDYPTAMTP-------------------------------------TSPRRYSPVAKD 343
+Y T++ P SPR YSPV D
Sbjct: 416 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 475
Query: 344 ---------------LLGEEDIPR-----------------------EPRRIVIHRGSTG 365
LL + ++ EPR++V+H+GSTG
Sbjct: 476 KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 535
Query: 366 LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
LGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK A
Sbjct: 536 LGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
Query: 426 GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKT 485
GQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+
Sbjct: 596 GQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKS 655
Query: 486 KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL 545
KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RL
Sbjct: 656 KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARL 715
Query: 546 KAKDWGSSSG--------------------------------------SQGREDSVLSYE 567
K + + G +G+ED +LSYE
Sbjct: 716 KTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYE 775
Query: 568 TVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVS 627
VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV
Sbjct: 776 PVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVI 835
Query: 628 SREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLH 687
SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+
Sbjct: 836 SREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLY 895
Query: 688 PIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKV 747
PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+ E+IY++
Sbjct: 896 PIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQC 955
Query: 748 KRVIEDLSGPYIWVPARERL 767
K VIE+ SGP+IW+P++E+L
Sbjct: 956 KLVIEEQSGPFIWIPSKEKL 975
Score = 33.5 bits (75), Expect = 0.76
Identities = 15/26 (57%), Positives = 19/26 (73%)
Query: 29 VLHSDLFQALLDILDYYEASLSESQK 54
+ S LFQALLDI ++YE +L SQK
Sbjct: 3 IFKSSLFQALLDIQEFYEVTLLNSQK 28
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 958 bits (2477), Expect = 0.0
Identities = 470/700 (67%), Positives = 572/700 (81%), Gaps = 29/700 (4%)
Query: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
QVNG++G +YEEI LERGNSGLGFSIAGG DNPH+ DDP IFITKIIPGGAAA DGRL
Sbjct: 119 QVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLG 178
Query: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGF 215
VND +L VNEVDV EV HS AVEALKEAG +VRL V RR+PP E +ME+ L+KGPKGLGF
Sbjct: 179 VNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGF 238
Query: 216 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 275
SIAGG+GNQHIPGDNSIY+TKIIEGGAA KDGRLQIGD++LAVN+ L+DV HE+AVA+L
Sbjct: 239 SIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASL 298
Query: 276 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG--------TDYPT 327
KNT D+VYLKVAKP + +L+D YAPPD ++++ DN ISH+S LG YP
Sbjct: 299 KNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP- 357
Query: 328 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAG 387
A P RYSP+ + +L EED REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAG
Sbjct: 358 APPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAG 417
Query: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKI 447
GPADLSGELR+GD+ILSVNGV+LRNA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KI
Sbjct: 418 GPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKI 477
Query: 448 HDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVID 507
HDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYD+T+D SQ LSF +GD+LHVI+
Sbjct: 478 HDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN 537
Query: 508 ASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLK--------------------A 547
ASD+EWWQAR V E++ IG IPSK+RVE++E +RLK +
Sbjct: 538 ASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLS 597
Query: 548 KDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVP 607
D+ + +G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP KFGSCVP
Sbjct: 598 DDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVP 657
Query: 608 HTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGK 667
HTTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSVR VAE+GK
Sbjct: 658 HTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGK 717
Query: 668 HCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEF 727
HCILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+A KLEQEF
Sbjct: 718 HCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEF 777
Query: 728 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 778 GEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 590 bits (1521), Expect = e-168
Identities = 293/468 (62%), Positives = 364/468 (77%), Gaps = 52/468 (11%)
Query: 352 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGELR+GD+ILSVNGV+LR
Sbjct: 45 REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 104
Query: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
NA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KIHDLREQ+MNSS+ SG+ SLR++ K
Sbjct: 105 NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 164
Query: 472 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 531
R Y+RALFDYD+T+D SQ LSF +GD+LHVI+ASD+EWWQAR V E++ IG I
Sbjct: 165 RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI 224
Query: 532 PSKRRVER-----------------------------------REWSRLKAKD------- 549
PSK+RVE+ R++ K+K+
Sbjct: 225 PSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESS 284
Query: 550 ----------WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFP 599
S S S+G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP
Sbjct: 285 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP 344
Query: 600 DKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSV 659
KFGSCVPHTTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSV
Sbjct: 345 HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV 404
Query: 660 REVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDR 719
R VAE+GKHCILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+
Sbjct: 405 RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK 464
Query: 720 ATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
A KLEQEF E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 465 AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/136 (34%), Positives = 69/136 (50%), Gaps = 8/136 (5%)
Query: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
E +I L +G++GLGF+I GG D IF++ I+ GG A G LR D IL VN
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVN 99
Query: 165 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK-GPKGLGFSIAGGVGN 223
V++R TH A ALK AG V + V + +P E K+ + + S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158
Query: 224 QHIPGDNSIYVTKIIE 239
S+YV + +
Sbjct: 159 LRTSEKRSLYVRALFD 174
Score = 60.1 bits (144), Expect = 8e-09
Identities = 35/79 (44%), Positives = 46/79 (58%), Gaps = 6/79 (7%)
Query: 198 AEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 257
A + +I L KG GLGF+I GG + I+V+ I+ GG A G L+ GD+IL+
Sbjct: 44 AREPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILS 97
Query: 258 VNSVGLEDVMHEDAVAALK 276
VN V L + HE A AALK
Sbjct: 98 VNGVNLRNATHEQAAAALK 116
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 447 bits (1150), Expect = e-125
Identities = 213/334 (63%), Positives = 270/334 (80%), Gaps = 20/334 (5%)
Query: 454 LMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW 513
+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 514 WQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGS----------------- 556
WQARRV + +++++G IPSKRRVER+E +RLK + + G
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT 120
Query: 557 ---QGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 613
+G+ED +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPK
Sbjct: 121 KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 180
Query: 614 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 673
R+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDV
Sbjct: 181 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 240
Query: 674 SANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSA 733
S NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+A
Sbjct: 241 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA 300
Query: 734 IVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
IV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 301 IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 192 bits (488), Expect = 1e-48
Identities = 160/636 (25%), Positives = 279/636 (43%), Gaps = 128/636 (20%)
Query: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
+P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+ GD+
Sbjct: 1342 RPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEYGDQ 1393
Query: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
+L N + L + A + D + + + + S++ S HLD
Sbjct: 1394 LLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS------SSHLDPA 1447
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR----------------EPRRIV 358
+HS+ G+ TP P P+ + G P EPR +
Sbjct: 1448 GTHSTLQGSG---TTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVF 1504
Query: 359 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418
I + LG ++ GG + G+F++ + PA L GD IL +D+RN + E+
Sbjct: 1505 IKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEV 1563
Query: 419 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 478
+ + V + QY+PEE+++ + P FYIRA
Sbjct: 1564 YVEMLKPRDGVRLKVQYRPEEFTK-----------------------AKGLPGDSFYIRA 1600
Query: 479 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSDSETDDIGFIPSK- 534
L YD+ D + Q LSF+ D+L+V D + W A ++ +++ G IPSK
Sbjct: 1601 L--YDRLAD---VEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKY 1655
Query: 535 -------RRVE------------------RREWSRLKAK---------------DWGSSS 554
RR+ RR + R K K D SS
Sbjct: 1656 VMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSD 1715
Query: 555 GSQGREDSV-LSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 613
EDSV L+Y+ V +++ RP++ILGP D + L++E P KF C +
Sbjct: 1716 SIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK-- 1773
Query: 614 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 673
+S++ +E+ ++ F++ + + H T+V S++E+ E+ +HC+LD+
Sbjct: 1774 -------------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1820
Query: 674 SANAVRRLQAAHLHPIAIFIRPRSLENVLE------INKRITEEQARKAFDRATKLEQEF 727
+ +A+ RL H++PI IFI +S +++ E + ++T+ +++ F+ A KLEQE+
Sbjct: 1821 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880
Query: 728 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA 763
+ F+ +++G + I ++ ++ +W+PA
Sbjct: 1881 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 96.3 bits (238), Expect = 1e-19
Identities = 76/260 (29%), Positives = 127/260 (48%), Gaps = 41/260 (15%)
Query: 32 SDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAP 91
+D+ + L ++ + E+ L + ++R + HS S ++TD++E
Sbjct: 573 NDVSRELKELKEQMESQLEKEARFRQL------MAHS---------SHDSAIDTDSME-- 615
Query: 92 GYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD 151
+E +V E E E E+I L+ LGF +A G + P D IF+TK+ G A D
Sbjct: 616 -WETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--D 666
Query: 152 GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV---MEIKLIK 208
GRLRVND +L +N+VD+ A++AL + + V RRK KV + I L
Sbjct: 667 GRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-S 725
Query: 209 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMH 268
G K G S+ +N +Y ++ G A K+G L +GD+I+A+N + L++
Sbjct: 726 GQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSL 774
Query: 269 EDAVAALKNTYDVVYLKVAK 288
+ + L++ D + L + K
Sbjct: 775 NECESLLRSCQDSLTLSLLK 794
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 364 TGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418
T L N+ G +D G++ + +L G PA G L GD+I+++NG+ L N S +
Sbjct: 718 TPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNEC 777
Query: 419 AIALKNAGQTVTI 431
L++ ++T+
Sbjct: 778 ESLLRSCQDSLTL 790
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 189 bits (481), Expect = 6e-48
Identities = 130/428 (30%), Positives = 201/428 (46%), Gaps = 73/428 (17%)
Query: 377 EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA--- 433
+ + IS I+ GG A+ SG L +GD++L +NG+++R + L + T+T +
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
Query: 434 -QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----C 488
Q KP E IH ++A FDYD + D C
Sbjct: 336 QQIKPPPAK--ETVIH---------------------------VKAHFDYDPSDDPYVPC 366
Query: 489 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERRE------- 541
L LSF+ GD+LHVI D WWQA R + G +P K ++RE
Sbjct: 367 RELG--LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIE 424
Query: 542 -----------WSRLKAKD------WGSSSGSQGREDSVLSYETVT--QMEVHYARPIII 582
W K K + ++ + +L+YE ++ + RPII+
Sbjct: 425 EDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIIL 484
Query: 583 LGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAH 639
+GP N+ L+++ D+F S VPHTTR +R+ E+ GRDYHFVS R+ E DI A
Sbjct: 485 IGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS-RQAFEADIAAG 543
Query: 640 KFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLE 699
KFIE G++ +LYGTS+ SVR+V GK C+L + +++ L+ + L P IFI P S E
Sbjct: 544 KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQE 603
Query: 700 NVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLS 755
+ + K E+ R+ ++ ++EQ F + ++ Y ++ R+I L
Sbjct: 604 RLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLD 663
Query: 756 GPYIWVPA 763
WVP+
Sbjct: 664 TEPQWVPS 671
Score = 37.7 bits (86), Expect = 0.040
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 204 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 165 bits (418), Expect = 1e-40
Identities = 136/480 (28%), Positives = 203/480 (42%), Gaps = 90/480 (18%)
Query: 339 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 398
P+ +D+ EED + R + + LG I E I ++ I+ GG AD SG +
Sbjct: 125 PMPEDIDDEEDSVKIIRLV---KNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHV 181
Query: 399 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNS 457
GD++ VNG+ + + E+ L + +T I EE E K+
Sbjct: 182 GDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKM---------- 231
Query: 458 SLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQ 515
+I+ALFDY+ +D + LSF+ GD+L ++ D WWQ
Sbjct: 232 -----------------FIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQ 274
Query: 516 ARRVHSDSETDDIGFIPSKRRVERR------------------------EWSRLKAKD-- 549
A+ H G IPSK ERR + RL KD
Sbjct: 275 AK--HEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKK 332
Query: 550 -----WGSSSGSQGREDSVLSYETVT----QMEVHYARPIIILGPTKDRAND---DLLSE 597
+ Q V +YE VT Q Y R ++++GP N+ LL
Sbjct: 333 TNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-RLVVLVGPVGVGLNELKRKLLIS 391
Query: 598 FPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQ 657
+G VPHTTR +R E DG +Y F+S + E D+Q +KFIE G+Y ++ YGTS+
Sbjct: 392 DTQHYGVTVPHTTRARRSQESDGVEYIFIS-KHLFETDVQNNKFIEYGEYKNNYYGTSID 450
Query: 658 SVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR---------- 707
SVR V + K C+LDV + V+ L+ P IFI+P S+E + E K
Sbjct: 451 SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQ 510
Query: 708 -----ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
TEE ++ A +E ++ F I+ D ++++K + L WVP
Sbjct: 511 GAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 199 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 258
+ V I+L+K + LG +I + +I V +I+ GGAA + G + +GD++ V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
Query: 259 NSVGLEDVMHEDAVAALKNTYDVVYLKV 286
N + +ED E+ + L + + K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 161 bits (407), Expect = 2e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 104 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 196
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 197 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 240
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
Query: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
+ S L + ++ + T T TP P S L + P I +
Sbjct: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
Query: 361 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Score = 121 bits (304), Expect = 2e-27
Identities = 90/236 (38%), Positives = 120/236 (50%), Gaps = 18/236 (7%)
Query: 64 PLEHSPAHLPNQANSPPVIVNTDTLEAPGY-----ELQVNGTEGEMEYEEITLERGNSGL 118
PL HS P A + T T PG L EG EEI L R L
Sbjct: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
Query: 119 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 176 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 230
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
Query: 231 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 107 bits (266), Expect = 5e-23
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 111 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 169
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 170 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 202
E H AV L A + L + R PP V
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 203 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 240
EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
Query: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
P + Q E S G G PR+P
Sbjct: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
Query: 361 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
Query: 421 ALKNAGQTVTII 432
L++ G T+T++
Sbjct: 1176 LLRSVGDTLTVL 1187
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 118 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 174 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 225
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 161 bits (407), Expect = 2e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 104 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 196
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 197 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 240
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
Query: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
+ S L + ++ + T T TP P S L + P I +
Sbjct: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
Query: 361 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Score = 121 bits (304), Expect = 2e-27
Identities = 90/236 (38%), Positives = 120/236 (50%), Gaps = 18/236 (7%)
Query: 64 PLEHSPAHLPNQANSPPVIVNTDTLEAPGY-----ELQVNGTEGEMEYEEITLERGNSGL 118
PL HS P A + T T PG L EG EEI L R L
Sbjct: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
Query: 119 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 176 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 230
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
Query: 231 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 107 bits (266), Expect = 5e-23
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 111 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 169
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 170 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 202
E H AV L A + L + R PP V
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 203 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 240
EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
Query: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
P + Q E S G G PR+P
Sbjct: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
Query: 361 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
Query: 421 ALKNAGQTVTII 432
L++ G T+T++
Sbjct: 1176 LLRSVGDTLTVL 1187
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 118 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 174 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 225
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 155 bits (392), Expect = 1e-37
Identities = 124/480 (25%), Positives = 218/480 (45%), Gaps = 42/480 (8%)
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 371
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 447 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 506
Query: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 430
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 507 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 565
Query: 431 -IIAQYKPEEYSRFEAKIHDLREQLMN--SSLGSGTASLRSN--PK-RGFYIRALFDYDK 484
I+ Y+ + S R+ N SS + + L S PK R Y+RA F+YD
Sbjct: 566 KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP 625
Query: 485 TKD--CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR-- 540
KD + FR GD++ +I D WWQ + +S + T G IPS E R
Sbjct: 626 AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVA 683
Query: 541 ---------------EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGP 585
W K K + ++ D V +YE V ++ + +++LG
Sbjct: 684 CIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLV-TYEEVVKLPAFKRKTLVLLGA 742
Query: 586 T---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFI 642
+ + L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++
Sbjct: 743 HGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYL 801
Query: 643 EAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVL 702
E G + +YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 802 EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGL 861
Query: 703 EINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 862 N-----EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 916
Score = 37.4 bits (85), Expect = 0.053
Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 9/123 (7%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+ P
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIV-P 569
Query: 290 SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR-------RYSPVAK 342
S S S +TS Q N S ++ +D P+ P + Y P
Sbjct: 570 SYRTQSSSCERDSPSTS-RQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKD 628
Query: 343 DLL 345
DL+
Sbjct: 629 DLI 631
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 152 bits (384), Expect = 1e-36
Identities = 124/466 (26%), Positives = 206/466 (44%), Gaps = 72/466 (15%)
Query: 333 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADL 392
SP + + + +P + RI+ G + + + I+ IL GG D
Sbjct: 106 SPPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDR 165
Query: 393 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLRE 452
G L GD I VNG ++ N E + LKN +VT+
Sbjct: 166 QGLLHVGDIIKEVNGHEVGNNPKELQEL-LKNISGSVTL--------------------- 203
Query: 453 QLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFRFGDVLHVIDASD 510
+++ S + T P++ F ++ FDY+ D L F G++L +++ D
Sbjct: 204 KILPSYRDTIT------PQQVF-VKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNRED 256
Query: 511 EEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDS-------- 562
WWQA V E G IPS+ E+R+ +DW +S G S
Sbjct: 257 PNWWQASHV---KEGGSAGLIPSQFLEEKRK--AFVRRDWDNSGPFCGTISSKKKKKMMY 311
Query: 563 ------------VLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEF----PDKFGSCV 606
+ YE V +M + ++++G + L + F P +FG+ V
Sbjct: 312 LTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIG-AQGVGRRSLKNRFIVLNPTRFGTTV 370
Query: 607 PHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQG 666
P T+R RE E DG+ Y FVS R +ME DI+A K++E G+Y +LYGT + S+ EV + G
Sbjct: 371 PFTSRKPREDEKDGQAYKFVS-RSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTG 429
Query: 667 KHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI----------TEEQARKA 716
+ CILDV+ A++ L+ + P +FI LE + ++K + T+ +K
Sbjct: 430 RTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKT 489
Query: 717 FDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
D + ++++ + F I+ D+ ++ + K++ IE L WVP
Sbjct: 490 VDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVP 535
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 150 bits (378), Expect = 6e-36
Identities = 119/475 (25%), Positives = 213/475 (44%), Gaps = 55/475 (11%)
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 371
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 447 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 506
Query: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 430
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 507 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 565
Query: 431 -IIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD-- 487
I+ Y+ + S E L +++ G R Y+RA F+YD KD
Sbjct: 566 KIVPSYRTQSSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDL 607
Query: 488 CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR------- 540
+ FR GD++ +I D WWQ + +S + T G IPS E R
Sbjct: 608 IPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVACIAME 665
Query: 541 ----------EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---K 587
W K K + ++ D V +YE V ++ + +++LG +
Sbjct: 666 KTKQEQQASCTWFGKKKKQYKDKYLAKHNADLV-TYEEVVKLPAFKRKTLVLLGAHGVGR 724
Query: 588 DRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQY 647
+ L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++E G +
Sbjct: 725 RHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYLEYGSH 783
Query: 648 NSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR 707
+YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 784 EDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLN---- 839
Query: 708 ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 840 -EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 893
Score = 33.9 bits (76), Expect = 0.58
Identities = 15/57 (26%), Positives = 27/57 (47%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 6e-36
Identities = 107/408 (26%), Positives = 186/408 (45%), Gaps = 68/408 (16%)
Query: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 440
++ IL GG G L GD+IL +NG ++ N S +Q A+K +++ + P +
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
Query: 441 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFR 498
SR P ++RA FDYD KD L F
Sbjct: 154 SRL--------------------------PALQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
Query: 499 FGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREW---------------- 542
GD++ +I+ D WWQ R S E+ G IPS E +EW
Sbjct: 188 TGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSP---ELQEWRVASMAQSAPSEAPSC 242
Query: 543 ----SRLKAKD-WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---KDRANDDL 594
+ K KD + + S + V+SYE V ++ + ++++G + + + L
Sbjct: 243 SPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
Query: 595 LSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 654
LS+ P+KF VP+TTRP R+ E DG++YHF+S+ E+M ++I A++F+E G Y +++GT
Sbjct: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFIST-EEMTRNISANEFLEFGSYQGNMFGT 361
Query: 655 SVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQAR 714
++V ++ +Q K ILD+ ++ ++ A L P +FI P E +++ ++
Sbjct: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
Query: 715 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
+ + ++ F + + +E K++ + WVP
Sbjct: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
Score = 40.8 bits (94), Expect = 0.005
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 231 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
S V +I+ GG H+ G L +GD+IL +N + + + A+K T ++ LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 39.7 bits (91), Expect = 0.011
Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 27/195 (13%)
Query: 69 PAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE----MEYEEITLERGNSGLGFSIAG 124
P + + N+ + T+ APG QV G E +++E++T E +G ++
Sbjct: 33 PEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEP----MGITLK- 87
Query: 125 GTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAG 184
+ + S + +I+ GG + G L V D IL +N +V + +A+KE
Sbjct: 88 ------LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETK 141
Query: 185 SIVRLYVM----RRKPPAEKVMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSI 232
++ L V+ R P + M + P K G A G Q I D+S
Sbjct: 142 GMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSN 201
Query: 233 YVTKIIEGGAAHKDG 247
+ +EG + G
Sbjct: 202 WWQGRVEGSSKESAG 216
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 148 bits (373), Expect = 2e-35
Identities = 128/502 (25%), Positives = 213/502 (42%), Gaps = 84/502 (16%)
Query: 304 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 363
T + H+ E S L T A SP + +P + R+V R +
Sbjct: 87 TAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKT 146
Query: 364 TGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 423
G + +G + I+ IL GG G L GD I VNG + S +A
Sbjct: 147 AGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV--GSDPRA----- 199
Query: 424 NAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK-------RGFYI 476
L+E L N+S G+ L+ P R ++
Sbjct: 200 --------------------------LQELLRNAS---GSVILKILPSYQEPHLPRQVFV 230
Query: 477 RALFDYDKTKDCGFLSQALSFRF--GDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSK 534
+ FDYD +D + RF GD+L +++ D WWQA V S G IPS+
Sbjct: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSA----GLIPSQ 286
Query: 535 RRVERR--------EWSRLKAKDWGSSSGSQGRE-------------DSVLSYETVTQME 573
E+R E + GS SG + + +L YE V +M
Sbjct: 287 LLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMP 346
Query: 574 VHYARPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 630
+ ++++G + + L+ PD++G+ VP+T+R ++ E +G+ Y FVS R
Sbjct: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVS-RG 405
Query: 631 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 690
+ME D++A +++E G+Y +LYGT + S+R V GK C+LDV+ AV+ L+ A P
Sbjct: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
Query: 691 IFIRPRSLENVLEIN----------KRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 740
+FI E + +N K++TE R+ + ++++++ + F + +
Sbjct: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
Query: 741 EEIYHKVKRVIEDLSGPYIWVP 762
E + +++ +E L WVP
Sbjct: 526 ERTFRELQTAMEKLRTEPQWVP 547
Score = 31.6 bits (70), Expect = 2.9
Identities = 47/170 (27%), Positives = 63/170 (37%), Gaps = 41/170 (24%)
Query: 23 APPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVI 82
A L +L FQ+LL+ D + E TPP SP P +N P
Sbjct: 88 AAELAHILQEPHFQSLLETHDSVASKTYE----------TPP--PSPGLDPTFSNQP--- 132
Query: 83 VNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKI 142
V D + G + T GE + G+ F + GG + I +I
Sbjct: 133 VPPDAVRMVG----IRKTAGE-----------HLGVTFRVEGG----------ELVIARI 167
Query: 143 IPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192
+ GG AQ G L V D I VN V A E L+ A V L ++
Sbjct: 168 LHGGMVAQQGLLHVGDIIKEVNGQPVGS-DPRALQELLRNASGSVILKIL 216
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 147 bits (371), Expect = 4e-35
Identities = 115/479 (24%), Positives = 215/479 (44%), Gaps = 58/479 (12%)
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 371
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 441 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 500
Query: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 430
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 501 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 559
Query: 431 -IIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD-- 487
I+ Y+ + S E L +++ G R Y+RA F+YD KD
Sbjct: 560 KIVPSYRTQSSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDL 601
Query: 488 CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKR---------RVE 538
+ FR GD++ +I D WWQ + +S + T G IPS +E
Sbjct: 602 IPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVACIAME 659
Query: 539 RREWSRLKAKDWGSSSGSQGRED------------SVLSYETVTQMEVHYARPIIILGPT 586
+ + + + W Q ++ +++YE V ++ + +++LG
Sbjct: 660 KTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAH 719
Query: 587 ---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIE 643
+ + L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++E
Sbjct: 720 GVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYLE 778
Query: 644 AGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLE 703
G + +YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 779 YGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLN 838
Query: 704 INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 839 -----EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 892
Score = 33.9 bits (76), Expect = 0.58
Identities = 15/57 (26%), Positives = 27/57 (47%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 147 bits (370), Expect = 5e-35
Identities = 126/484 (26%), Positives = 213/484 (44%), Gaps = 98/484 (20%)
Query: 347 EEDIPREPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 405
+ED E +IV + + LG I E + ++ I+ GG AD SG + GD++ V
Sbjct: 127 DEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 406 NGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 464
NG+ + + ++ + L + ++T+ I EE E+K+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKV----------------- 229
Query: 465 SLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQARRVHSD 522
++RALF Y+ +D Q L F+ VL V+ D WWQA+RV
Sbjct: 230 ----------FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDT 279
Query: 523 SETDDIGFIPSKRRVER------------------------------------------- 539
+ G IPSK ER
Sbjct: 280 NLR--AGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVA 337
Query: 540 --REWSRLKAKD--WGSSSG--SQGRED-SVLSYETVTQMEVHYA---RPIIILGPTKDR 589
R RL ++ GS G S G E +L+YE V + + R ++++G R
Sbjct: 338 GLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGAR 397
Query: 590 AND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ 646
++ +++E P FG VPHTTRP++ +E +G +YHFVS ++ E D+ +KF+E G+
Sbjct: 398 LHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVS-KQAFEADLHHNKFLEHGE 456
Query: 647 YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLEN------ 700
Y +LYGTS+++++ V + K C++DV A+++L+ + P IF++P E
Sbjct: 457 YKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPM 516
Query: 701 --VLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPY 758
E +EQ ++ A +++ + A++ + + Y ++K V+E LS
Sbjct: 517 SPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDT 576
Query: 759 IWVP 762
WVP
Sbjct: 577 HWVP 580
Score = 37.4 bits (85), Expect = 0.053
Identities = 22/88 (25%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 199 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 258
E V ++L+K + LG +I ++H ++ V +I+ GGAA + G + +GD++ V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 259 NSVGLEDVMHEDAVAALKNTYDVVYLKV 286
N + + ++ L + + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 138 bits (348), Expect = 2e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 320 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 379
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Query: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 437
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
Query: 438 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 497
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
Query: 498 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 538
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
Query: 539 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 590
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
Query: 591 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 650
+ L E PD Y+I + + ++ I+ H
Sbjct: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
Query: 651 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 710
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
Query: 711 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 761
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 63.5 bits (153), Expect = 7e-10
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 212 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 270
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 271 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 324
AV L+ + + + + + S P+ + + +E H G
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 325 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 380
+P + + R SP + P +P ++ + + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 105 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
Query: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 195
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 341 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 392
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 393 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 438
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 439 --EYSRFEAKIHDLR 451
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 204 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
Query: 262 GLEDVMHEDAVAAL 275
+++ E+AV L
Sbjct: 474 DFTNIIREEAVLFL 487
Score = 36.6 bits (83), Expect = 0.090
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 292 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 336
A L + D S + ++IS L +D+ PRR
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
Score = 35.8 bits (81), Expect = 0.15
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 30/171 (17%)
Query: 52 SQKYRYQDEDTPP------LEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEME 105
S ++ D+ TP +E + P+ PV P +L V+ ++G +
Sbjct: 353 STPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQ---PDVDLPVSPSDGVLP 409
Query: 106 ---YEEITLE--------RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRL 154
+E+ L R +G +AGG +D IF+ ++ AA++G L
Sbjct: 410 NSTHEDGILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-L 461
Query: 155 RVNDSILFVNEVDVREVTHSAAVEALKE--AGSIVRLYVMRRKPPAEKVME 203
D IL VN VD + AV L + G V + ++K +++E
Sbjct: 462 EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 138 bits (348), Expect = 2e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 320 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 379
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Query: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 437
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
Query: 438 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 497
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
Query: 498 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 538
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
Query: 539 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 590
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
Query: 591 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 650
+ L E PD Y+I + + ++ I+ H
Sbjct: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
Query: 651 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 710
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
Query: 711 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 761
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 63.5 bits (153), Expect = 7e-10
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 212 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 270
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 271 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 324
AV L+ + + + + + S P+ + + +E H G
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 325 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 380
+P + + R SP + P +P ++ + + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 105 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
Query: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 195
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 341 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 392
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 393 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 438
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 439 --EYSRFEAKIHDLR 451
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 204 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
Query: 262 GLEDVMHEDAVAAL 275
+++ E+AV L
Sbjct: 474 DFTNIIREEAVLFL 487
Score = 36.6 bits (83), Expect = 0.090
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 292 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 336
A L + D S + ++IS L +D+ PRR
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
Score = 35.8 bits (81), Expect = 0.15
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 30/171 (17%)
Query: 52 SQKYRYQDEDTPP------LEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEME 105
S ++ D+ TP +E + P+ PV P +L V+ ++G +
Sbjct: 353 STPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQ---PDVDLPVSPSDGVLP 409
Query: 106 ---YEEITLE--------RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRL 154
+E+ L R +G +AGG +D IF+ ++ AA++G L
Sbjct: 410 NSTHEDGILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-L 461
Query: 155 RVNDSILFVNEVDVREVTHSAAVEALKE--AGSIVRLYVMRRKPPAEKVME 203
D IL VN VD + AV L + G V + ++K +++E
Sbjct: 462 EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 135 bits (340), Expect = 1e-31
Identities = 107/331 (32%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
I + +G SGLG SI GG D P +I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
Query: 169 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLI------KGPKGLGFSIAGGVG 222
R +H A+ AL++ VRL V R + +++ K +GLG SI G
Sbjct: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
Query: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
+ ++++ I++GGAA DGRL GD+IL+VN + + E LK +V
Sbjct: 1554 G------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
Query: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTA---MTPTSPRRYSP 339
L++ + + + TTS + + +HSS + P +R S
Sbjct: 1608 QLEIGRLRAGSWTSAR-----TTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSD 1662
Query: 340 VAKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSG 394
++ G + EPR + I+R S LG +I GG +FI+ I A G A +
Sbjct: 1663 PSQKNSGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
Query: 395 ELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
+L+ GD+I+S+NG L SH LKNA
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 120 bits (302), Expect = 4e-27
Identities = 101/399 (25%), Positives = 162/399 (40%), Gaps = 84/399 (21%)
Query: 107 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166
EE+ L SGLGF I GG + + + I+PGG A +DGRL+ D IL +
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 167 DVREVTHSAAVEALKEAGSIVRLYVMRRK-------PPAEKVMEIKL----IKGP----- 210
+V+ +T + L+ G+ VR+ V R PPA + + L KGP
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 211 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
+ LG I G VG H + IYV II G AA+ +G +Q+ DKI+
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL----- 311
AV+ V ++ + D V L+N VV+L + + + + PP + + L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
Query: 312 ---------------DNEI-----------------------SHSSYLGTDYPTAMTPTS 333
D EI S + L + + + P
Sbjct: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
Query: 334 PRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLS 393
+ + + + ++ + + + IH G+ + G +IS I++GGP D
Sbjct: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTL 595
Query: 394 GELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432
G L+ D++L VNG+ L S +A LK T++
Sbjct: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
Score = 103 bits (258), Expect = 5e-22
Identities = 96/354 (27%), Positives = 157/354 (44%), Gaps = 68/354 (19%)
Query: 105 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV 163
+ E I +ER ++G LGFS+ + ++G IF+ + PG A +D RL+ ND IL +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
Query: 164 NEVDV-REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK--------------------VM 202
N + + ++H A+ L++ +RL ++ R+P K V
Sbjct: 189 NHTPLDQNISHQQAIALLQQTTGSLRL-IVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
Query: 203 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 262
E++LI GLGF I GG + + V I+ GG A +DGRLQ GD IL +
Sbjct: 248 EVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 263 LEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 322
++ + E L+N + V + VA+ + S PP
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI--SVTPP--------------------- 337
Query: 323 TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRI-VIHRGSTGLGFNIVG----GEDGE 377
P A+ P VA G + E + ++ + LG IVG GE
Sbjct: 338 --APAALPVALP----TVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
Query: 378 --GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
GI++ I+ G A +G ++ D+I++V+GV+++ ++ L+NAGQ V
Sbjct: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
Score = 97.4 bits (241), Expect = 4e-20
Identities = 108/418 (25%), Positives = 170/418 (40%), Gaps = 75/418 (17%)
Query: 204 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 263
I+L K GLG S+AG + SI+V I G A DGR++IGD++L +N+ L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 264 EDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE--------- 314
H++A A +K V L + +A + P + +S ++++
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 315 -------------------ISHSSYLGTDYPTAMT------PTSPRR------------- 336
++ S YPT ++ P +P
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 337 --YSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG--EGIFISFILAGGPADL 392
+P++ D +P + I I +G +GLG +IVGG+D I I + G A
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAAR 1475
Query: 393 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLRE 452
G L GDQIL VNGVDLRN+SHE+A AL+ Q V ++ Y+ E + R E +
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENLEIFPV 1534
Query: 453 QLM-NSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDE 511
L + G G + + G +I + G L Q GD + ++ D
Sbjct: 1535 DLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQ------GDQILSVNGED- 1587
Query: 512 EWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGS----SSGSQGREDSVLS 565
+ + S+ + + + + E RL+A W S S SQG + S S
Sbjct: 1588 -------MRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
Score = 80.1 bits (196), Expect = 7e-15
Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 26/252 (10%)
Query: 204 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
+++ + P LG SI GG + + G I++ +++E A K L+ GDKI
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 256 LAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
L V+ V L++ H +AV A+KN + VV++ + S + + + +Q+ D +
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQ 1185
Query: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE------------DIPREPRRIVIHRG 362
GT P P + + + + E+ D+P E I + +
Sbjct: 1186 EKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD 1245
Query: 363 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
GLG ++ G +D IF+ I GPA G +R GD++L +N L SH+ A+
Sbjct: 1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
Query: 421 ALKNAGQTVTII 432
+K A V ++
Sbjct: 1306 IIKTAPSKVKLV 1317
Score = 77.0 bits (188), Expect = 6e-14
Identities = 63/234 (26%), Positives = 108/234 (46%), Gaps = 57/234 (24%)
Query: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE-DVMHED 270
GLGFS+ + +Q++ G I+V + G A +D RL+ D+ILA+N L+ ++ H+
Sbjct: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 271 AVAALKNTYDVVYLKVAKP-------SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 323
A+A L+ T + L VA+ +++ L+D+ P + + + ++
Sbjct: 202 AIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVE----------- 250
Query: 324 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 383
+I+ GS GLGF IVGG+ G+ +
Sbjct: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
Query: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 437
I+ GG AD G L+ GD IL + G +++ + EQ A L+N G +V ++ P
Sbjct: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/92 (44%), Positives = 54/92 (58%), Gaps = 11/92 (11%)
Query: 354 PRRIVIHRG-STGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRKGDQI 402
PR + I R + LG +IVGG E+ +GIFI +L PA + L+ GD+I
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 403 LSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
L V+GVDL+NASH +A A+KNAG V I Q
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/98 (41%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 196 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
P E ++EI KG GLG SI GG N+I + ++ E GAA +DGRL GD+I
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 256 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAY 293
L VN V L + HE+A+ AL+ T V L V + Y
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHY 1523
Score = 55.5 bits (132), Expect = 2e-07
Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 2/79 (2%)
Query: 213 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272
LG SIAGG G+ GD +++ I G A + +L++GD+I+++N L+ + H D V
Sbjct: 1687 LGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVV 1744
Query: 273 AALKNTYDVVYLKVAKPSN 291
LKN Y + L+V +N
Sbjct: 1745 NLLKNAYGRIILQVVADTN 1763
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/258 (25%), Positives = 98/258 (37%), Gaps = 58/258 (22%)
Query: 229 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 288
D Y++ I+ GG G LQ D++L VN + L +AV+ LK
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE----------- 626
Query: 289 PSNAYLSDSYAPPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE 347
PP T + L D+E S D P + P D+ E
Sbjct: 627 ----------VPPPFTLVCCRRLFDDEAS------VDEPRRTETSLPETEVDHNMDVNTE 670
Query: 348 ED-------IPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGE 395
ED E + + + + GLGF+I+ +D I I ++A G A+ SG
Sbjct: 671 EDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGG 730
Query: 396 LRKGDQILSVNGVDLRNASHEQAAIALK------------------NAGQTVTIIAQYKP 437
L GD+++SVN L N S +A LK N ++ I+
Sbjct: 731 LLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSN 790
Query: 438 EEYSRFEAKIHDLREQLM 455
E+ + F IHD+ L+
Sbjct: 791 EDKTEFSGTIHDINSSLI 808
Score = 52.0 bits (123), Expect = 2e-06
Identities = 47/147 (31%), Positives = 71/147 (48%), Gaps = 17/147 (11%)
Query: 56 RYQDEDTPPLEHSPAHLPNQANSPPVIVN----TDTLEAPGYELQVNGTE-------GEM 104
R + ED P +H + ++A++ +++ TDT E P E + G E G
Sbjct: 1008 RREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPERE-EGEGEETPNFSHWGPP 1066
Query: 105 EYEEITLERGNSGLGFSIAGGTD---NPHIGDD-PSIFITKIIPGGAAAQDGRLRVNDSI 160
EI E N LG SI GG G++ IFI +++ A + L+ D I
Sbjct: 1067 RIVEIFREP-NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 161 LFVNEVDVREVTHSAAVEALKEAGSIV 187
L V+ VD++ +HS AVEA+K AG+ V
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 41/192 (21%)
Query: 138 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-- 195
+I+ I+ GG G L+ D +L VN + + + AV LKE L RR
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 196 ---------------PPAE----------------------KVMEIKLIKGPKGLGFSIA 218
P E +V ++L+K KGLGFSI
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 219 GGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 278
+ P + I + ++ G A + G L GD++++VN L++ +AV LK
Sbjct: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Query: 279 -YDVVYLKVAKP 289
+V+L + KP
Sbjct: 761 PPGLVHLGICKP 772
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 6/92 (6%)
Query: 352 REPRRIVIHRGSTG-LGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVN 406
R+ I I R STG LGF++V IF+ + G AD L++ DQIL++N
Sbjct: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
Query: 407 GVDL-RNASHEQAAIALKNAGQTVTIIAQYKP 437
L +N SH+QA L+ ++ +I +P
Sbjct: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
E + + L + GLGFSI D P I I ++ G A + G L D ++ VN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 165 EVDVREVTHSAAVEALK 181
E + + + AVE LK
Sbjct: 742 EYCLDNTSLAEAVEILK 758
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 129 bits (324), Expect = 1e-29
Identities = 102/344 (29%), Positives = 156/344 (45%), Gaps = 58/344 (16%)
Query: 112 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171
++ GLG SI G + D +F++ I+ GG A DGRL D IL VN DVR
Sbjct: 1730 KKPGKGLGLSIVGKRN------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
Query: 172 THSAAVEALKEAGSIVRLYVM---------------RRKPPAEKVMEIKLIKGPKG---- 212
T A LK + + + ++ A ++ ++ ++ KG
Sbjct: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
Query: 213 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272
LG SIAGGVG+ GD I++ + G A + +L++GD+I+ + E + H AV
Sbjct: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
Query: 273 AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 332
LKN + ++V A D++ + S S+ G T
Sbjct: 1902 NLLKNASGSIEMQVV-----------AGGDVSVVTGHQQEPASSSLSFTGL--------T 1942
Query: 333 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEG----IFISFILAGG 388
S S + +D LG P + + I + RG GLGF+IVGG I++ + A G
Sbjct: 1943 S----SSIFQDDLG----PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKG 1994
Query: 389 PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432
A G L++GDQI++VNG L +HE+A LK TVT++
Sbjct: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 123 bits (308), Expect = 7e-28
Identities = 119/383 (31%), Positives = 167/383 (43%), Gaps = 58/383 (15%)
Query: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
E I LE+G+SGLG S+AG D + S+FI I P GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
Query: 165 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE----------------------KVM 202
+ +H A +K A S V++ +R K K
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 203 EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGR 248
E + + S V + +P D + + + + E G A DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 249 LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYS 308
L++GD+ILAV+ + E ++ LK V L + +A DS A P + S
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI----HAENPDSQAVPSAAGAAS 1578
Query: 309 QHLDNEISHSSYL---GTDYPTAMTPTSPRRYSPV--AKDLLGEEDIPREPRRIVIHRGS 363
N S S + G+ P ++ TS R +P A D IP I I +G
Sbjct: 1579 GEKKNS-SQSLMVPQSGSPEPESIRNTS-RSSTPAIFASDPATCPIIPGCETTIEISKGR 1636
Query: 364 TGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIA 421
TGLG +IVGG D I I + G A G L GDQIL VNG+DLR A+H++A
Sbjct: 1637 TGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINV 1696
Query: 422 LKNAGQTVTII-----AQYKPEE 439
L+ Q V + A YK EE
Sbjct: 1697 LRQTPQRVRLTLYRDEAPYKEEE 1719
Score = 121 bits (304), Expect = 2e-27
Identities = 102/332 (30%), Positives = 152/332 (45%), Gaps = 61/332 (18%)
Query: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
I + +G +GLG SI GG+D +G +I I ++ GAA +DGRL D IL VN +D+
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTL-LG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
Query: 169 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK-----VMEIKLIKGP-KGLGFSIAGGVG 222
R+ TH A+ L++ VRL + R + P ++ + I+L K P KGLG SI G
Sbjct: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
Query: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
D ++V+ I++GG A DGRL GD+IL VN + + E A LK
Sbjct: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK------ 1793
Query: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342
+S S +P + + TS S K
Sbjct: 1794 --------------------------------VSEGSLSSFTFPLSGSSTSESLESSSKK 1821
Query: 343 DLLGEEDIPREPRRIVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELR 397
+ L E + R + + +G T LG +I GG IFI+ + G A + +LR
Sbjct: 1822 NALASE--IQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
Query: 398 KGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429
GD+I+++ G +H QA LKNA ++
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSI 1911
Score = 120 bits (302), Expect = 4e-27
Identities = 97/382 (25%), Positives = 165/382 (43%), Gaps = 64/382 (16%)
Query: 107 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166
E I L SGLGF I GG + + I+PGG A Q GRL D IL + +
Sbjct: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
Query: 167 DVREVTHSAAVEALKEAGSIVRLYVMR--------------------------------R 194
D+ ++ + L++ G+ V+L + R +
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
Query: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
K + +++L K +GLG +IAG +G++ + + I+V I + A DGR+QIGD+
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
Query: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT-------TSY 307
I+AV+ L+ ++ AV L++T V L + + ++ + D+T +
Sbjct: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
Query: 308 SQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH-RGSTGL 366
S +N +L + T + PT Y ++ ++ ED ++ ++ + G+
Sbjct: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGI 547
Query: 367 GFNIV-------GGEDGEGI---------FISFILAGGPADLSGELRKGDQILSVNGVDL 410
+ IV G GI FI +L GP SG+L GD++L VNG+ L
Sbjct: 548 NYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITL 607
Query: 411 RNASHEQAAIALKNAGQTVTII 432
+H+ LK VT++
Sbjct: 608 LGENHQDVVNILKELPIEVTMV 629
Score = 115 bits (289), Expect = 1e-25
Identities = 81/210 (38%), Positives = 107/210 (50%), Gaps = 36/210 (17%)
Query: 109 ITLERG-NSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
+ +++G LG SIAGG +P +GD P IFI + P G AAQ +LRV D I+ +
Sbjct: 1834 VEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
Query: 168 VREVTHSAAVEALKEAGSIVRLYVM----------RRKPPAEKVME-------------- 203
+TH+ AV LK A + + V+ ++ PA +
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL 1951
Query: 204 -------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
I L +GP GLGFSI GG G+ H GD IYV + GAA +DGRL+ GD+I+
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQII 2009
Query: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
AVN LE V HE+AVA LK T V L V
Sbjct: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 107 bits (267), Expect = 4e-23
Identities = 117/460 (25%), Positives = 187/460 (40%), Gaps = 92/460 (20%)
Query: 26 LLTVLHSDLFQALLDILDYYE-----ASLSESQKYRYQDEDTPPLEHSPAHLPNQANSP- 79
L +VL S LF +L + + +++ S + P L SPA +P N
Sbjct: 36 LKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHL--SPAVIPTLQNESF 93
Query: 80 ---PVIVNTDTLEAPGYELQVNGTEGEMEYEEIT--------------LERGNSGLGFSI 122
P N + L PG +NG E++++ L+ + GLGFS+
Sbjct: 94 LLSPNNGNLEALTGPGIP-HINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSV 152
Query: 123 AGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE-VTHSAAVEALK 181
G + IF+ +I G A +DGRL+ D IL +N + + +TH A+ L+
Sbjct: 153 VGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQ 210
Query: 182 EAGSIVRLYVMR------------RKPPAEKVME-------------IKLIKGPKGLGFS 216
+A V+L + R R P A + I+L+ GLGF
Sbjct: 211 KAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFG 270
Query: 217 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 276
I GG + V I+ GG A + GRL GD IL + L + E L+
Sbjct: 271 IIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 277 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 336
+ V L +A+ + + + AP + + S +PTS
Sbjct: 324 QCGNRVKLMIARGA---IEERTAPTALGITLSS--------------------SPTSTPE 360
Query: 337 YSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG--GE---DGEGIFISFILAGGPAD 391
A GEE E + + + GLG I G G+ + GIF+ I +
Sbjct: 361 LRVDASTQKGEES---ETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVE 417
Query: 392 LSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
G ++ GDQI++V+G +L+ +++QA L++ GQTV +
Sbjct: 418 HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL 457
Score = 93.6 bits (231), Expect = 6e-19
Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 44/233 (18%)
Query: 205 KLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 263
+L+K P G LGFS+ G G+ I+V +I EG AH+DGRL+ D+ILA+N L
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
Query: 264 ED-VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 322
+ + H+ A++ L+ D V L +A+ S
Sbjct: 197 DQTITHQQAISILQKAKDTVQLVIARGS-------------------------------- 224
Query: 323 TDYPTAMTPTSPRRYSPVAKDLLGEEDIP---REPRRIVIHRGSTGLGFNIVGGEDGEGI 379
P ++P R SP A + P + I + +GLGF I+GG+ G+
Sbjct: 225 --LPQLVSPIVSR--SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK-ATGV 279
Query: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432
+ IL GG AD G L GD IL + DL S EQ A L+ G V ++
Sbjct: 280 IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLM 332
Score = 93.6 bits (231), Expect = 6e-19
Identities = 95/307 (30%), Positives = 138/307 (44%), Gaps = 79/307 (25%)
Query: 204 IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 260
I + KG LG +++ G+G + V II GGA +DGR+ IGD IL++N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 261 VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSY--SQHLDN-EIS- 316
V + A A L+ S PDI +Y ++HL+ +IS
Sbjct: 1060 ESTISVTNAQARAMLRR------------------HSLIGPDIKITYVPAEHLEEFKISL 1101
Query: 317 ------------HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR--------EPRR 356
SSY G D P P ++ GEE + +PRR
Sbjct: 1102 GQQSGRVMALDIFSSYTGRDIPEL----------PEREEGEGEESELQNTAYSNWNQPRR 1151
Query: 357 IVIHRG-STGLGFNIVGGE-------DGE---GIFISFILAGGPADLSGELRKGDQILSV 405
+ + R S LG +IVGG +GE GIFI +L PA +G L+ GD+I+ V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 406 NGVDLRNASHEQAAIALKNAGQTVTIIAQ---YKPEEYSRFEAKIHDLREQLMNSSLGSG 462
+G+DLR+ASHEQA A++ AG V + Q +P + S + +H+L + SS
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPF 1270
Query: 463 TASLRSN 469
SL+ N
Sbjct: 1271 ADSLQIN 1277
Score = 77.8 bits (190), Expect = 4e-14
Identities = 109/452 (24%), Positives = 182/452 (40%), Gaps = 80/452 (17%)
Query: 36 QALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYEL 95
Q+ LD LD + L+E P + + PV+ TD ++ E+
Sbjct: 640 QSELDSLDLCDIELTEK-----------PHVDLGEFIGSSETEDPVLAMTDAGQSTE-EV 687
Query: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
Q E + I LE+G+ GLGFSI D P I I ++PGG A +DGRL
Sbjct: 688 QAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLL 746
Query: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGS-IVRLYVMRRKP--PAEKVMEIK------- 205
D ++FVN+V++ + AVEALK A S VR+ V + P P E + K
Sbjct: 747 PGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYP 806
Query: 206 -------------------LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK---IIEGGAA 243
+ G + + P ++SIY T+ + G++
Sbjct: 807 PHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSS 866
Query: 244 HKDGRLQIG----------------DKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA 287
DG L G D +L ++ + LE++ ++ + V + +
Sbjct: 867 CGDG-LNYGSSLPSSPPKDVIENSCDPVLDLH-MSLEELYTQNLLQRQDENTPSVDISMG 924
Query: 288 KPSNAYLSDSYAPPD-ITTSY---------SQHLDNEISHSSYLGTDYPTAMTPTSPRRY 337
P++ + + Y P + I Y HL +E+ S+ L + P + S
Sbjct: 925 -PASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLL 983
Query: 338 SPVAKDLLGE----EDIPRE--PRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPAD 391
+ E +++ +E R I I +G++ LG + +DG G+ + I+ GG
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAIS 1043
Query: 392 LSGELRKGDQILSVNGVDLRNASHEQAAIALK 423
G + GD ILS+N + ++ QA L+
Sbjct: 1044 RDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 76.3 bits (186), Expect = 1e-13
Identities = 74/268 (27%), Positives = 109/268 (40%), Gaps = 21/268 (7%)
Query: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271
GLG S+ VG+ ++ ++ G G+L GD++L VN + L H+D
Sbjct: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
Query: 272 VAALKNTYDVVYL----KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPT 327
V LK V + + P+ DS DI + H+D S D
Sbjct: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
Query: 328 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFIS 382
AMT A + E I + I + +GS GLGF+I+ +D I I
Sbjct: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
Query: 383 FILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSR 442
++ GG A+ G L GD+++ VN V+L N+S E+A ALK A I KP S
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Query: 443 FEAKIHDLREQLMNSSLGSGTASLRSNP 470
E + + + A L P
Sbjct: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKP 819
Score = 72.8 bits (177), Expect = 1e-12
Identities = 42/91 (46%), Positives = 54/91 (59%), Gaps = 2/91 (2%)
Query: 102 GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 161
G + + ITLERG GLGFSI GG +PH GD P I++ + GAA++DGRL+ D I+
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQII 2009
Query: 162 FVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192
VN + VTH AV LK V L V+
Sbjct: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 60.5 bits (145), Expect = 6e-09
Identities = 68/252 (26%), Positives = 95/252 (37%), Gaps = 66/252 (26%)
Query: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
++ G E+ ++ NSGLG S+ T H FI ++P G G+L
Sbjct: 543 RIMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLF 594
Query: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-PPAEK-------VMEIKLI 207
D +L VN + + H V LKE V + RR PP + + +I+L
Sbjct: 595 SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELT 654
Query: 208 KGPK-GLGFSIAGG---------------------------VGNQHI------------- 226
+ P LG I G QHI
Sbjct: 655 EKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSI 714
Query: 227 --------PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 278
P I + ++ GG A KDGRL GD+++ VN V LE+ E+AV ALK
Sbjct: 715 LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
Query: 279 -YDVVYLKVAKP 289
V + VAKP
Sbjct: 775 PSGTVRIGVAKP 786
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/119 (31%), Positives = 62/119 (52%), Gaps = 10/119 (8%)
Query: 81 VIVNTDTLEAPGYELQVNGTEGE-MEYEEITLERGNSGLGFSIAGGTDNPHIGD---DPS 136
+ +++ P + + +GE E ++ L + GLG +IAG +IGD +PS
Sbjct: 349 ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG-----YIGDKKLEPS 403
Query: 137 -IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194
IF+ I A DGR+++ D I+ V+ +++ T+ AVE L+ G V L +MRR
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 19/180 (10%)
Query: 41 ILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNT-----------DTLE 89
I DY A+ E Q+Y ++ H P+ + + A P V+ ++ +L
Sbjct: 931 INDYTPANAIE-QQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLA 989
Query: 90 APGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAA 149
+ + E I + +GNS LG +++ D + + II GGA +
Sbjct: 990 CNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAIS 1043
Query: 150 QDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG 209
+DGR+ + D IL +NE VT++ A A+ S++ + PAE + E K+ G
Sbjct: 1044 RDGRIAIGDCILSINEESTISVTNAQA-RAMLRRHSLIGPDIKITYVPAEHLEEFKISLG 1102
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 10/80 (12%)
Query: 115 NSGLGFSIAGGTDNPHIGDDPS-------IFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
+ LG SI GG +G S IFI ++ A ++G L+ D I+ V+ +D
Sbjct: 1159 SKSLGISIVGGRG---MGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMD 1215
Query: 168 VREVTHSAAVEALKEAGSIV 187
+R+ +H AVEA+++AG+ V
Sbjct: 1216 LRDASHEQAVEAIRKAGNPV 1235
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/138 (23%), Positives = 58/138 (42%), Gaps = 16/138 (11%)
Query: 64 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIA 123
PL + +L N+ P V + ++ ++ + + L + GLG +I+
Sbjct: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFK----------NVQHLELPKDQGGLGIAIS 1498
Query: 124 GGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA 183
++ G + I + G AA DGRL+V D IL V++ V + LK A
Sbjct: 1499 --EEDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA 1552
Query: 184 GSIVRLYVMRRKPPAEKV 201
V+L + P ++ V
Sbjct: 1553 KMTVKLTIHAENPDSQAV 1570
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 127 bits (320), Expect = 3e-29
Identities = 154/639 (24%), Positives = 244/639 (38%), Gaps = 175/639 (27%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
+ I++ I + G A + LQ GD IL +N V +++ D ++ + + L V +
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
Query: 290 SNAYL-------SDSYAPP-------------------DITTSYSQHLDNEISHSSYLGT 323
+L SDS + P D+ + SQ + I
Sbjct: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
Query: 324 DYPTAMTPTSP------RRYSPVAKDLLGEED-----IPREPR----------------- 355
P A SP RR S V + E D +PRE
Sbjct: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
Query: 356 ----RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
R+V +G + GG D GIF+S + AG PAD G +++GDQIL VN V +
Sbjct: 411 SPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQ 468
Query: 412 NASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSN 469
N + E+A L G+ + ++ Q K D+ +++ S +G
Sbjct: 469 NLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGDS------- 510
Query: 470 PKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA---------SDEEWWQARRVH 520
FYIR F+ + + G L F GDV HV+D + W A R+
Sbjct: 511 ----FYIRTHFELEPSPPSG-----LGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMG 561
Query: 521 SDSETDDIGFIPSKRRVE------------------------RREWSRLKAKDWGSSSGS 556
D + G IP++ R E R E+ RL+ G+ +
Sbjct: 562 RDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT 621
Query: 557 Q-GRED-SVLS-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKF--GSC 605
Q RED S L+ YE V E + RP++ILGP D A L +E PD+F
Sbjct: 622 QRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAET 681
Query: 606 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ 665
V T P + ++D +VR +AE+
Sbjct: 682 VSRTDSPSKIIKLD--------------------------------------TVRVIAEK 703
Query: 666 GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATK 722
KH +LDV+ +A+ RL +PI +F P S + + + + + R+ + +A K
Sbjct: 704 DKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQK 763
Query: 723 LEQEFTECFSAIVE-GDSFEEIYHKVKRVIEDLSGPYIW 760
L + + F+A + + + Y ++K +I + IW
Sbjct: 764 LRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/247 (26%), Positives = 94/247 (38%), Gaps = 49/247 (19%)
Query: 206 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
L K P+ G G +I+GG + PG S+ V+ ++ GG A +GRLQ GD I+ VN V +E
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
Query: 265 DVMHEDAVAALKNTYDVVYLKVAKPSNAYL--------------SDSYAPPDITTSYSQH 310
+ A+ LK + + V +P +L SD P Q
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
Query: 311 LDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK---------------------DLLGEED 349
+ SS G + P R L +D
Sbjct: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
Query: 350 IPREPRRIVI--HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 407
+ +P + V+ R S G + G IFI I G A L++GD IL +NG
Sbjct: 207 VQMKPVKSVLVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQING 261
Query: 408 VDLRNAS 414
V +N S
Sbjct: 262 VSSQNLS 268
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 117 GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 176
G G +I+GG D P S+ ++ ++PGG A +GRL+ D I+ VN V + T + A
Sbjct: 40 GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93
Query: 177 VEALKEAGSIVRLYVMR 193
++ LK + + V R
Sbjct: 94 IQILKTCTKMANITVKR 110
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 12/84 (14%)
Query: 350 IPREPRRIVIHRGSTGLGFNIVGGED--GEGIFISFILAGGPADLSGELRKGDQILSVNG 407
+ ++PRR G G I GG D G + +S ++ GGPA+ G L+ GD I+ VNG
Sbjct: 33 LSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNG 82
Query: 408 VDLRNASHEQAAIALKNAGQTVTI 431
V + NA+ A LK + I
Sbjct: 83 VSMENATSAFAIQILKTCTKMANI 106
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 125 bits (314), Expect = 1e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 290 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 324
S L + S++P + YS + ++ D
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 325 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 355
P+ + TPT + +A ++ E + +EPR
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
Query: 356 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 407
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
Query: 408 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 465
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
Query: 466 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 522
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
Query: 523 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 564
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
Query: 565 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 617
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
Query: 618 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 677
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
Query: 678 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 734
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
Query: 735 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 761
+ +S + + +K I+ G +WV
Sbjct: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 67.8 bits (164), Expect = 4e-11
Identities = 41/117 (35%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 79 PPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPS 136
PP + L APG E + E +TL++ + G G +++GG DNPH + + S
Sbjct: 10 PPRRELSGWLRAPGMEELI------WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETS 63
Query: 137 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 193
I I+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 64 IVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 211 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 269
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 270 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 303
AV L+ + V + V +P ++ A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 346 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 397
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 398 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 192 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 247
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
Query: 248 RLQIGDKILAVNSVGLEDVMHEDAVAAL 275
LQ GD+IL VN+ ++ EDAV L
Sbjct: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 33.1 bits (74), Expect = 1.00
Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 11/88 (12%)
Query: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 169 REVTHSAAVEALKE--AGSIVRLYVMRR 194
R + AV L E G +V + R
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSR 591
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 125 bits (314), Expect = 1e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 290 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 324
S L + S++P + YS + ++ D
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 325 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 355
P+ + TPT + +A ++ E + +EPR
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
Query: 356 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 407
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
Query: 408 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 465
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
Query: 466 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 522
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
Query: 523 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 564
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
Query: 565 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 617
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
Query: 618 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 677
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
Query: 678 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 734
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
Query: 735 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 761
+ +S + + +K I+ G +WV
Sbjct: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 67.8 bits (164), Expect = 4e-11
Identities = 41/117 (35%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 79 PPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPS 136
PP + L APG E + E +TL++ + G G +++GG DNPH + + S
Sbjct: 10 PPRRELSGWLRAPGMEELI------WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETS 63
Query: 137 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 193
I I+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 64 IVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 211 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 269
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 270 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 303
AV L+ + V + V +P ++ A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 346 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 397
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 398 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 192 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 247
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
Query: 248 RLQIGDKILAVNSVGLEDVMHEDAVAAL 275
LQ GD+IL VN+ ++ EDAV L
Sbjct: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 33.1 bits (74), Expect = 1.00
Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 11/88 (12%)
Query: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
+ ++G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 169 REVTHSAAVEALKE--AGSIVRLYVMRR 194
R + AV L E G +V + R
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSR 591
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 117 bits (292), Expect = 5e-26
Identities = 62/201 (30%), Positives = 110/201 (54%), Gaps = 16/201 (7%)
Query: 578 RPIIILGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 634
R I+++GP+ N+ L+ P F S VPHTTR K+ YE++GR+YH+VS +E E
Sbjct: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS-KETFEN 486
Query: 635 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 694
I +H+ +E G+Y HLYGTSV +V+ V +GK C++D+ ++ ++ L P IFI+
Sbjct: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
Query: 695 PRSLENVLE------------INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEE 742
P ++ + + ++ + +E ++ + A ++E +F + F ++ DS +
Sbjct: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHD 606
Query: 743 IYHKVKRVIEDLSGPYIWVPA 763
++ I+ WVPA
Sbjct: 607 ACAQLLSAIQKAQEEPQWVPA 627
Score = 63.9 bits (154), Expect = 5e-10
Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 38/206 (18%)
Query: 348 EDIPR--EPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILS 404
++IP E RIV + + LG I E I ++ I+ GG A+ SG L GD+++
Sbjct: 143 DNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVE 202
Query: 405 VNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 464
VNGV + EQ L + T+ K+ + + +NS
Sbjct: 203 VNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS------- 241
Query: 465 SLRSNPKRGFYIRALFDY--DKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSD 522
++ Y+RA+ +Y + D + L F+ GD+L ++D +D WWQAR++ SD
Sbjct: 242 ------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI-SD 294
Query: 523 SETDDIGFIPSKRRVERRE----WSR 544
T G +PS ++R++ WS+
Sbjct: 295 PAT-CAGLVPSNHLLKRKQREFWWSQ 319
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 196 PPAEKVMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
P +E+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
Query: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
++ VN V +E + E + L + + KV S+
Sbjct: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
Score = 30.4 bits (67), Expect = 6.5
Identities = 46/192 (23%), Positives = 71/192 (36%), Gaps = 26/192 (13%)
Query: 26 LLTVLHSDLFQALLDILDYYE--------ASLSESQKYRYQ------DEDTPPLEHSPAH 71
L +LHS QALL I D + + +Q Y+ + T P
Sbjct: 53 LYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQ 112
Query: 72 LPNQANSPPVIVNTDTLEAPGYE-----LQVNGTEGEMEYEEITLERGNSGLGFSIAGGT 126
+ + ++ DT+ +E L N E E + L + LG +I
Sbjct: 113 MLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATI---K 169
Query: 127 DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL-KEAGS 185
+ GD I + +II GG A + G L D ++ VN V V + + L G+
Sbjct: 170 RHEMTGD---ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGT 226
Query: 186 IVRLYVMRRKPP 197
I+ V PP
Sbjct: 227 IMFKVVPVSDPP 238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,423,938
Number of Sequences: 37866
Number of extensions: 1421320
Number of successful extensions: 5196
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 3970
Number of HSP's gapped (non-prelim): 903
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.