Guide to the Human Genome
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Search of human proteins with 45545431

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
         (383 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]                859   0.0  
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]                859   0.0  
gi|110735443 delta-like 1 [Homo sapiens]                              245   6e-65
gi|74136023 delta-like 1 homolog [Homo sapiens]                       241   8e-64
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               240   2e-63
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              227   2e-59
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               227   2e-59
gi|4557679 jagged 1 precursor [Homo sapiens]                          225   6e-59
gi|24041035 notch 2 preproprotein [Homo sapiens]                      206   4e-53
gi|148833508 notch1 preproprotein [Homo sapiens]                      194   1e-49
gi|134244285 Notch homolog 3 [Homo sapiens]                           186   4e-47
gi|148886654 polydom [Homo sapiens]                                   185   5e-47
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 184   9e-47
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]    177   1e-44
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]   177   1e-44
gi|112420992 crumbs homolog 2 [Homo sapiens]                          169   5e-42
gi|55770876 notch4 preproprotein [Homo sapiens]                       164   1e-40
gi|4759146 slit homolog 2 [Homo sapiens]                              152   6e-37
gi|188528675 slit homolog 1 [Homo sapiens]                            150   2e-36
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     149   3e-36
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               147   2e-35
gi|11321571 slit homolog 3 [Homo sapiens]                             138   7e-33
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   135   8e-32
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   126   4e-29
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]    125   8e-29
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            121   9e-28
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           121   1e-27
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]   114   1e-25
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           107   1e-23
gi|153946395 tenascin C precursor [Homo sapiens]                      103   3e-22

>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score =  859 bits (2219), Expect = 0.0
 Identities = 383/383 (100%), Positives = 383/383 (100%)

Query: 1   MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
           MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
Sbjct: 1   MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60

Query: 61  VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
           VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL
Sbjct: 61  VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120

Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
           PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
Sbjct: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180

Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
           RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240

Query: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
           GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA
Sbjct: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300

Query: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
           GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV
Sbjct: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360

Query: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
           SMLPAGLPLPRDLPPEPGKTTAL
Sbjct: 361 SMLPAGLPLPRDLPPEPGKTTAL 383


>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score =  859 bits (2219), Expect = 0.0
 Identities = 383/383 (100%), Positives = 383/383 (100%)

Query: 1   MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
           MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
Sbjct: 1   MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60

Query: 61  VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
           VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL
Sbjct: 61  VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120

Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
           PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
Sbjct: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180

Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
           RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240

Query: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
           GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA
Sbjct: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300

Query: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
           GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV
Sbjct: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360

Query: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
           SMLPAGLPLPRDLPPEPGKTTAL
Sbjct: 361 SMLPAGLPLPRDLPPEPGKTTAL 383


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  245 bits (625), Expect = 6e-65
 Identities = 119/321 (37%), Positives = 145/321 (45%), Gaps = 73/321 (22%)

Query: 14  LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ 73
           +C  G  G       C   CD  HG C   G C+C  GW+G +C+ C+R PGC HGTC Q
Sbjct: 211 VCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQ 270

Query: 74  PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCER--- 130
           PWQC C  GW G FC++D + CT   PC+NG  C   G G Y C C PG+ G  CE    
Sbjct: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330

Query: 131 --KAGPCEQAGS-------------------------------PCRNGGQCQD--DQGFA 155
                PC+  GS                               PC NGG+C D  D G++
Sbjct: 331 ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390

Query: 156 LN----------------------------------FTCRCLVGFVGARCEVNVDDCLMR 181
                                               + CRC  GF G  C+ NVDDC   
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450

Query: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
           PCANG TC DG+N FSC CP G+ GR C+  +  C   PC  GA C +R H + C C  G
Sbjct: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510

Query: 242 YGGKTCELVLP-VPDPPTTVD 261
           YGG  C+ +LP +P  P  VD
Sbjct: 511 YGGPNCQFLLPELPPGPAVVD 531



 Score =  218 bits (554), Expect = 9e-57
 Identities = 107/295 (36%), Positives = 132/295 (44%), Gaps = 76/295 (25%)

Query: 27  DDCSSHCD-----LAHGCCAPDGSCRCDPGWE---------------------------- 53
           + CS  C        H  C   G   C+PGW+                            
Sbjct: 186 EGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKC 245

Query: 54  -----GLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM 108
                G +C+ C+R PGC HGTC QPWQC C  GW G FC++D + CT   PC+NG  C 
Sbjct: 246 RVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305

Query: 109 YDGGGEYHCVCLPGFHGRDCER-----KAGPCEQAGS----------------------- 140
             G G Y C C PG+ G  CE         PC+  GS                       
Sbjct: 306 NTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICEL 365

Query: 141 --------PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
                   PC NGG+C D       ++CRC VG+ G  CE  +D C   PC+NGA C+D 
Sbjct: 366 SAMTCADGPCFNGGRCSDSPDG--GYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL 423

Query: 193 INRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
            + + C C  GF+GR C  N+DDCAS PC  G  CRD V+DF C CP GY G+ C
Sbjct: 424 GDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478


>gi|74136023 delta-like 1 homolog [Homo sapiens]
          Length = 383

 Score =  241 bits (615), Expect = 8e-64
 Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)

Query: 10  LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69
           L+ +L +L A G      +C   C+  +G C  D  CRC PGW+G  C++CV  PGC HG
Sbjct: 7   LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66

Query: 70  TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
            C +P QCIC  GW G+ CD+D   C++ +PC N G C+    G Y C C PG+ G+DC+
Sbjct: 67  LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125

Query: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
           +K GPC   GSPC++GG C DD+G A + +C C  GF G  CE+  + C   PC N   C
Sbjct: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185

Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
            D    F C CP GF  + C+  + +CAS PCQ G  C       ++CLC   + G TC 
Sbjct: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244

Query: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306
           +      P      P G   A  + P     P       +L++S+KE+ ++    L E  
Sbjct: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303

Query: 307 LVALVVFGALTAALVLATV 325
            +   + G LT+ +VL TV
Sbjct: 304 AICFTILGVLTSLVVLGTV 322


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  240 bits (612), Expect = 2e-63
 Identities = 97/235 (41%), Positives = 136/235 (57%), Gaps = 6/235 (2%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
           C+ G  G+  +   C   C+L HG C   G CRC  GW+G  C+ CV  PGC HG+C +P
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290

Query: 75  WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
           WQC C + W G  CDKD + C +  PC NGG C+     +Y C C  G+ GR+CE+    
Sbjct: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C    +PC NGG C +       F C C  G+ G  C +++D+C   PCA G TC+D ++
Sbjct: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            F C+CPE + G  C ++++DC  + CQ G  C+D V+ + C+CP G+GG+ CEL
Sbjct: 406 GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459



 Score =  171 bits (433), Expect = 1e-42
 Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)

Query: 27  DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
           DDC        G C  +     C C  GWEG  C+     C+  P    G C+     + 
Sbjct: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
           C C  GW GK C   E  C   + C NGG C YD G  + C C PG+ G  C   K   C
Sbjct: 660 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 717

Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
               +PC NGG C    G   +F+C C  G+ G  C  N +DC   PC NG  C+DG+N 
Sbjct: 718 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 772

Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
           F C C  GFAG  C IN+D+C S PC  GA C D ++ + C CP G  G  C+ V+
Sbjct: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828



 Score =  170 bits (430), Expect = 2e-42
 Identities = 91/253 (35%), Positives = 116/253 (45%), Gaps = 38/253 (15%)

Query: 27  DDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PW 75
           +DC   C   HG    D      C C  G+ G HCE     C   P    G C      +
Sbjct: 425 NDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482

Query: 76  QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
            C C  G++G  C+ D  +C   SPC+NG +C Y+  G+Y+C C   F G++C     PC
Sbjct: 483 HCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPC 540

Query: 136 EQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARCEVN 174
              G  CR    C  D G  +                     NF+C C  GF G  C  N
Sbjct: 541 P--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598

Query: 175 VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
           +DDCL +PC NG TC+D ++ F C CP G+ G  C  N +DC   PC    RC D V+DF
Sbjct: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 658

Query: 235 DCLCPSGYGGKTC 247
            C C  G+ GKTC
Sbjct: 659 YCACDDGWKGKTC 671



 Score =  147 bits (370), Expect = 2e-35
 Identities = 96/292 (32%), Positives = 116/292 (39%), Gaps = 80/292 (27%)

Query: 29  CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
           C+S+     G C   P G  C C  GW G  C    + C   P    GTC      ++CI
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410

Query: 79  CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
           C   W G  C  D + C  Q  CQ+GG C  D    Y CVC  GF GR CE +   C  A
Sbjct: 411 CPEQWVGATCQLDVNDCRGQ--CQHGGTCK-DLVNGYQCVCPRGFGGRHCELERDEC--A 465

Query: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL------------------- 179
            SPC +GG C+D    A  F C C  GF G  CEV+VD C                    
Sbjct: 466 SSPCHSGGLCED---LADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 522

Query: 180 --------------MRPCANGA-----------------TCLDGI------------NRF 196
                           PC  GA                 T   G+              F
Sbjct: 523 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582

Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
           SC+C  GF G +C  N+DDC  +PC+ G  C D V  F C CPSG+ G+ C+
Sbjct: 583 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 68/275 (24%), Positives = 88/275 (32%), Gaps = 68/275 (24%)

Query: 25  RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHC-----ERCVRMPGCQHGTC---HQ 73
           R   C ++     G C   G    C C PGW+G  C       C+  P    GTC     
Sbjct: 674 REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA 733

Query: 74  PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM------------------------- 108
            + CIC  GW G+ C  + + C    PC NGG C+                         
Sbjct: 734 SFSCICRDGWEGRTCTHNTNDCNPL-PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 792

Query: 109 ------------YDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRNGGQCQDDQG 153
                        D    Y C C PG  G  C+   G    C   G+P  +G    +D  
Sbjct: 793 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN 852

Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
                +CRCL G    R + +   C  +PC             S  CP G   R      
Sbjct: 853 -----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG--QRCLEKAP 897

Query: 214 DDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
             C   PC+    C  +      CL  SG+    C
Sbjct: 898 GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  227 bits (578), Expect = 2e-59
 Identities = 104/283 (36%), Positives = 134/283 (47%), Gaps = 44/283 (15%)

Query: 9   HLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
           H VC     L C+ G  G+  +   C S C   +G C+    C C PGW+G  C  C+  
Sbjct: 197 HYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH 256

Query: 64  PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
            GC+HGTC  PWQC C  GW G FCD+D + CT  SPC+NG  C   G   Y C C PG+
Sbjct: 257 NGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGY 316

Query: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQ---------GF-------------------- 154
            G DCE +   C+   +PCRNGG C+D +         G+                    
Sbjct: 317 TGVDCELELSECDS--NPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNG 374

Query: 155 --------ALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
                     N+ C C   F G+ CE  VD C   PCANG  CL+      C C  GF G
Sbjct: 375 GSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTG 434

Query: 207 RFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            +C +++ DCA  PC  G  C D  +   C CP+G+ G+ CE+
Sbjct: 435 TYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV 477



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 64/197 (32%), Positives = 76/197 (38%), Gaps = 51/197 (25%)

Query: 28  DCSSHCDLAHGCCAP--DG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQPWQ---- 76
           +C S+     G C    DG  C C PG+ GLHCE     C   P    G+C +  Q    
Sbjct: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY 386

Query: 77  -CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG------------------------ 111
            C C   + G  C+K    CT+ +PC NGGQC+  G                        
Sbjct: 387 ACECPPNFTGSNCEKKVDRCTS-NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA 445

Query: 112 ------GGEYH-------CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
                 GG  H       C C  GF GR CE +      A SPC N   C  D      F
Sbjct: 446 RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS-TDTF 504

Query: 159 TCRCLVGFVGARCEVNV 175
            C C  GFVG+RCE  V
Sbjct: 505 VCNCPYGFVGSRCEFPV 521


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  227 bits (578), Expect = 2e-59
 Identities = 97/272 (35%), Positives = 136/272 (50%), Gaps = 42/272 (15%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
           C+ G  G+  +   C   C+L HG C   G CRC  GW+G  C+ CV  PGC HG+C +P
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290

Query: 75  WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
           WQC C + W G  CDKD + C +  PC NGG C+     +Y C C  G+ GR+CE+    
Sbjct: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C    +PC NGG C +       F C C  G+ G  C +++D+C   PCA G TC+D ++
Sbjct: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRP---------------------------------- 220
            F C+CPE + G  C ++ ++C  +P                                  
Sbjct: 406 GFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC 465

Query: 221 ---CQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
              CQ G  C+D V+ + C+CP G+GG+ CEL
Sbjct: 466 RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL 497



 Score =  171 bits (433), Expect = 1e-42
 Identities = 91/256 (35%), Positives = 117/256 (45%), Gaps = 38/256 (14%)

Query: 24  VRADDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ-- 73
           +  +DC   C   HG    D      C C  G+ G HCE     C   P    G C    
Sbjct: 460 INVNDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 517

Query: 74  -PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
             + C C  G++G  C+ D  +C   SPC+NG +C Y+  G+Y+C C   F G++C    
Sbjct: 518 DGFHCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPR 575

Query: 133 GPCEQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARC 171
            PC   G  CR    C  D G  +                     NF+C C  GF G  C
Sbjct: 576 EPCP--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633

Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV 231
             N+DDCL +PC NG TC+D ++ F C CP G+ G  C  N +DC   PC    RC D V
Sbjct: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693

Query: 232 HDFDCLCPSGYGGKTC 247
           +DF C C  G+ GKTC
Sbjct: 694 NDFYCACDDGWKGKTC 709



 Score =  171 bits (433), Expect = 1e-42
 Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)

Query: 27  DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
           DDC        G C  +     C C  GWEG  C+     C+  P    G C+     + 
Sbjct: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
           C C  GW GK C   E  C   + C NGG C YD G  + C C PG+ G  C   K   C
Sbjct: 698 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 755

Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
               +PC NGG C    G   +F+C C  G+ G  C  N +DC   PC NG  C+DG+N 
Sbjct: 756 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 810

Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
           F C C  GFAG  C IN+D+C S PC  GA C D ++ + C CP G  G  C+ V+
Sbjct: 811 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866



 Score =  159 bits (401), Expect = 5e-39
 Identities = 88/258 (34%), Positives = 119/258 (46%), Gaps = 19/258 (7%)

Query: 29  CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
           C+S+     G C   P G  C C  GW G  C    + C   P    GTC      ++CI
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410

Query: 79  CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
           C   W G  C  D + C  + PC N   C    GG Y+C C+PG+ G +C      C   
Sbjct: 411 CPEQWVGATCQLDANECEGK-PCLNAFSCKNLIGG-YYCDCIPGWKGINCHINVNDCR-- 466

Query: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
              C++GG C+D       + C C  GF G  CE+  D+C   PC +G  C D  + F C
Sbjct: 467 -GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHC 522

Query: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPDPP 257
            CP+GF+G  C +++D C   PC+ GARC +   D+ C CP  +GGK C +   P P   
Sbjct: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582

Query: 258 TTVDTPLGPTSAVVVPAT 275
             V    G  +   +P T
Sbjct: 583 CRVIDGCGSDAGPGMPGT 600



 Score =  147 bits (372), Expect = 1e-35
 Identities = 83/233 (35%), Positives = 113/233 (48%), Gaps = 37/233 (15%)

Query: 46  CRCDPGWEGLHCERCVR--MPGCQHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
           C C PGW+G++C   V      CQHG TC      +QC+C  G+ G+ C+ +   C + S
Sbjct: 447 CDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-S 505

Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
           PC +GG C  D    +HC C  GF G  CE     CE   SPCRNG +C + +G   ++ 
Sbjct: 506 PCHSGGLCE-DLADGFHCHCPQGFSGPLCEVDVDLCEP--SPCRNGARCYNLEG---DYY 559

Query: 160 CRCLVGFVGARCEVNVDDC------LMRPCANGA------TCLDGI------------NR 195
           C C   F G  C V  + C      ++  C + A      T   G+              
Sbjct: 560 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 619

Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
           FSC+C  GF G +C  N+DDC  +PC+ G  C D V  F C CPSG+ G+ C+
Sbjct: 620 FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 672



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 68/275 (24%), Positives = 88/275 (32%), Gaps = 68/275 (24%)

Query: 25  RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHC-----ERCVRMPGCQHGTC---HQ 73
           R   C ++     G C   G    C C PGW+G  C       C+  P    GTC     
Sbjct: 712 REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA 771

Query: 74  PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM------------------------- 108
            + CIC  GW G+ C  + + C    PC NGG C+                         
Sbjct: 772 SFSCICRDGWEGRTCTHNTNDCNPL-PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 830

Query: 109 ------------YDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRNGGQCQDDQG 153
                        D    Y C C PG  G  C+   G    C   G+P  +G    +D  
Sbjct: 831 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN 890

Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
                +CRCL G    R + +   C  +PC             S  CP G   R      
Sbjct: 891 -----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG--QRCLEKAP 935

Query: 214 DDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
             C   PC+    C  +      CL  SG+    C
Sbjct: 936 GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  225 bits (573), Expect = 6e-59
 Identities = 89/235 (37%), Positives = 129/235 (54%), Gaps = 5/235 (2%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
           C+ G  G       C   C   HG C   G CRC  GW+GL+C++C+  PGC HG C++P
Sbjct: 220 CMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEP 279

Query: 75  WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
           WQC+C + W G+ CDKD + C T  PC NGG C   G  +Y C C  G+ G +CE     
Sbjct: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHA 339

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C     PC N G C++    +L F C C  G+ G  C  N+DDC    C++G TC D +N
Sbjct: 340 C--LSDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN 394

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            F C+CP  + G+ C ++ ++C ++PC     C++ +  + C C  G+ G+ C++
Sbjct: 395 GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449



 Score =  182 bits (463), Expect = 3e-46
 Identities = 96/274 (35%), Positives = 130/274 (47%), Gaps = 50/274 (18%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CV 61
           C+ G  GQ     +C  + +   G C  D SCR         C PG+ G HCER    C 
Sbjct: 438 CLPGWMGQ-----NCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492

Query: 62  RMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCV 118
             P    G C      +QC+C +G++G  C  D   C   +PCQNG QC Y+   +Y C 
Sbjct: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP-NPCQNGAQC-YNRASDYFCK 550

Query: 119 CLPGFHGRDCER-----KAGPCEQAGS--------------------PCRNGGQCQDDQG 153
           C   + G++C       +  PCE   S                     C   G+C+   G
Sbjct: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610

Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
               FTC C  GF G  C  N++DC   PC NG TC+DG+N + C+C +G+ G +C  N+
Sbjct: 611 G--KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668

Query: 214 DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
           +DC+  PC  G  CRD V+DF C C +G+ GKTC
Sbjct: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702



 Score =  169 bits (428), Expect = 4e-42
 Identities = 90/236 (38%), Positives = 119/236 (50%), Gaps = 20/236 (8%)

Query: 27  DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PW 75
           +DC S+     G C  DG     C C  GWEG +CE     C + P    GTC      +
Sbjct: 631 NDCESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689

Query: 76  QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGP 134
            C C +GW GK C   +  C  ++ C NGG C YD G  + C+C  G+ G  C   +   
Sbjct: 690 YCDCKNGWKGKTCHSRDSQCD-EATCNNGGTC-YDEGDAFKCMCPGGWEGTTCNIARNSS 747

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C    +PC NGG C  +     +FTC C  G+ G  C  N +DC   PC N  TC+DG N
Sbjct: 748 C--LPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
            + C C  GFAG  C IN+++C S PC  GA C D ++ + C+CP G+ G  C+ V
Sbjct: 803 WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858



 Score =  131 bits (330), Expect = 9e-31
 Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 41/237 (17%)

Query: 46  CRCDPGWEGLHCERCVR--MPGCQH-GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
           C C PGW G +C+  +   +  CQ+  +C      ++CIC  G+AG  C++D   C + +
Sbjct: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS-N 494

Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
           PC NGG C  +    + C+C  GF G  C+     CE   +PC+NG QC +    A ++ 
Sbjct: 495 PCLNGGHCQNEIN-RFQCLCPTGFSGNLCQLDIDYCEP--NPCQNGAQCYNR---ASDYF 548

Query: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCL---------DGIN---------------- 194
           C+C   + G  C    D C   PC    +C          +G+                 
Sbjct: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ 608

Query: 195 ---RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
              +F+C C +GF G +C  N++DC S PC+ G  C D V+ + C+C  G+ G  CE
Sbjct: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 66/203 (32%), Positives = 88/203 (43%), Gaps = 34/203 (16%)

Query: 38  GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
           G C  +G   +C C  GWEG  C +    C   P    GTC      ++C C  G+AG  
Sbjct: 757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816

Query: 88  CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG-PCEQAGSPCRNGG 146
           C  + + C + SPC  G  C+ +  G Y CVC PG  G  C+  +G PC   GS   +G 
Sbjct: 817 CRININECQS-SPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGA 874

Query: 147 QCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
           +  DD       TC+CL G    R   +   C  RPC         +++    CP   +G
Sbjct: 875 KWDDDCN-----TCQCLNG----RIACSKVWCGPRPCL--------LHKGHSECP---SG 914

Query: 207 RFCTINLDD-CASRPCQRGARCR 228
           + C   LDD C   PC     CR
Sbjct: 915 QSCIPILDDQCFVHPCTGVGECR 937


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  206 bits (523), Expect = 4e-53
 Identities = 99/251 (39%), Positives = 133/251 (52%), Gaps = 18/251 (7%)

Query: 12   CLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRM 63
            C+L   G   Q V A    + C+ A  C         +C C PGW+G  C    + C+  
Sbjct: 821  CVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISK 880

Query: 64   PGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
            P   HG CH     + C C  G++G  C++D   C   +PCQNGG CM DG   + C+CL
Sbjct: 881  PCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLA-NPCQNGGSCM-DGVNTFSCLCL 938

Query: 121  PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
            PGF G  C+     C     PC+NGG C D   +  ++TC+C  GF G  CE N+++C  
Sbjct: 939  PGFTGDKCQTDMNEC--LSEPCKNGGTCSD---YVNSYTCKCQAGFDGVHCENNINECTE 993

Query: 181  RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
              C NG TC+DGIN FSCLCP GF G FC   +++C+S PC     C D +  + C CP 
Sbjct: 994  SSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPL 1053

Query: 241  GYGGKTCELVL 251
            GY GK C+ ++
Sbjct: 1054 GYTGKNCQTLV 1064



 Score =  180 bits (456), Expect = 2e-45
 Identities = 94/263 (35%), Positives = 128/263 (48%), Gaps = 31/263 (11%)

Query: 14  LCILGAPGQPVRADDCSSHCD-LAHGCCAPDG---------SCRCDPGWEGLHC---ERC 60
           +C+ G  G     DDCS + D  A   C P           SC C  G  GL C   + C
Sbjct: 325 VCVNGWSG-----DDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDAC 379

Query: 61  VRMPG-----CQHGTCHQPWQCICHSGWAGKFC--DKDEHICTTQSPCQNGGQCMYDGGG 113
           +  P      C     +  + C C  G+ G  C  D DE      +PC++ G+C+ +  G
Sbjct: 380 ISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV-NTDG 438

Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
            +HC CL G+ G  CE     C     PC+N   C D  G    FTC C+ GF G  CE+
Sbjct: 439 AFHCECLKGYAGPRCEMDINECHS--DPCQNDATCLDKIG---GFTCLCMPGFKGVHCEL 493

Query: 174 NVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD 233
            +++C   PC N   C+D +NRF CLCP GF G  C I++DDC+S PC  GA+C D  + 
Sbjct: 494 EINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNG 553

Query: 234 FDCLCPSGYGGKTCELVLPVPDP 256
           ++C C +G+ G  CE  +   DP
Sbjct: 554 YECQCATGFTGVLCEENIDNCDP 576



 Score =  177 bits (450), Expect = 1e-44
 Identities = 96/258 (37%), Positives = 128/258 (49%), Gaps = 30/258 (11%)

Query: 14   LCILGAPGQPV--RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRM 63
            LC +G  G       ++CSSH  L  G C  DG     C C  G+ G +C+     C R 
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCV-DGLGTYRCSCPLGYTGKNCQTLVNLCSRS 1070

Query: 64   PGCQHGTCHQPW---QCICHSGWAGKFCDKDEHICTTQSP---------CQNGGQCMYDG 111
            P    GTC Q     QC+C SGWAG +CD     C   +          CQ+ G C+ + 
Sbjct: 1071 PCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCI-NA 1129

Query: 112  GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
            G  ++C C  G+ G  CE +   C  A +PC++G  C D   F   + C C+ G+ G  C
Sbjct: 1130 GNTHYCQCPLGYTGSYCEEQLDEC--ASNPCQHGATCSD---FIGGYRCECVPGYQGVNC 1184

Query: 172  EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP-CQRGARCRDR 230
            E  VD+C  +PC NG TC+D +N F C CP G  G  C  N+DDCA  P C  G +C DR
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDR 1244

Query: 231  VHDFDCLCPSGYGGKTCE 248
            +  + C C  G+ G+ CE
Sbjct: 1245 IGGYSCRCLPGFAGERCE 1262



 Score =  171 bits (433), Expect = 1e-42
 Identities = 97/249 (38%), Positives = 126/249 (50%), Gaps = 20/249 (8%)

Query: 15  CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
           C +G  G+  +  D C SH C     C   A   SC+C  G+ G  CE  V    +PG C
Sbjct: 133 CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 192

Query: 67  QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
           QHG TC      +QC C  G+ G++CD   ++    SPC NGG C   G   + C CLPG
Sbjct: 193 QHGGTCLNLPGSYQCQCPQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLPG 251

Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
           F G  CER    C      C+NGG C D       + CRC   + G  C  +VD+CL++P
Sbjct: 252 FEGSTCERNIDDCPN--HRCQNGGVCVDGVN---TYNCRCPPQWTGQFCTEDVDECLLQP 306

Query: 183 --CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
             C NG TC +    + C+C  G++G  C+ N+DDCA   C  G+ C DRV  F C+CP 
Sbjct: 307 NACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPE 366

Query: 241 GYGGKTCEL 249
           G  G  C L
Sbjct: 367 GKAGLLCHL 375



 Score =  166 bits (421), Expect = 2e-41
 Identities = 80/210 (38%), Positives = 112/210 (53%), Gaps = 13/210 (6%)

Query: 46  CRCDPGWEGLHCE---RCVRMPGCQHGTCH---QPWQCICHSGWAGKFCDKDEHICTTQS 99
           C C  G+ G  C+    C+  P     TC      + C C +G+ G+ C+ D + C    
Sbjct: 131 CTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPG 190

Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
            CQ+GG C+ +  G Y C C  GF G+ C+    PC  A SPC NGG C+    F   F 
Sbjct: 191 HCQHGGTCL-NLPGSYQCQCPQGFTGQYCDSLYVPC--APSPCVNGGTCRQTGDFT--FE 245

Query: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASR 219
           C CL GF G+ CE N+DDC    C NG  C+DG+N ++C CP  + G+FCT ++D+C  +
Sbjct: 246 CNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQ 305

Query: 220 P--CQRGARCRDRVHDFDCLCPSGYGGKTC 247
           P  CQ G  C +R   + C+C +G+ G  C
Sbjct: 306 PNACQNGGTCANRNGGYGCVCVNGWSGDDC 335



 Score =  161 bits (407), Expect = 1e-39
 Identities = 88/249 (35%), Positives = 118/249 (47%), Gaps = 22/249 (8%)

Query: 15  CILGAPGQPVRAD----DCSSHCDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMP 64
           C+ G  GQ    D    D   HC     C    GS  C+C  G+ G +C+     C   P
Sbjct: 170 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSP 229

Query: 65  GCQHGTCHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
               GTC Q     ++C C  G+ G  C+++   C     CQNGG C+ DG   Y+C C 
Sbjct: 230 CVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR-CQNGGVCV-DGVNTYNCRCP 287

Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
           P + G+ C      C    + C+NGG C +  G    + C C+ G+ G  C  N+DDC  
Sbjct: 288 PQWTGQFCTEDVDECLLQPNACQNGGTCANRNG---GYGCVCVNGWSGDDCSENIDDCAF 344

Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV--HDFDCLC 238
             C  G+TC+D +  FSC+CPEG AG  C ++ D C S PC +GA C        + C C
Sbjct: 345 ASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD-DACISNPCHKGALCDTNPLNGQYICTC 403

Query: 239 PSGYGGKTC 247
           P GY G  C
Sbjct: 404 PQGYKGADC 412



 Score =  157 bits (398), Expect = 1e-38
 Identities = 87/247 (35%), Positives = 120/247 (48%), Gaps = 21/247 (8%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHG---CCAPDG--SCRCDPGWEGLHCE----RCVRMPG 65
           C+ G  G     D    H D       C    G  +C C PG++G+HCE     C   P 
Sbjct: 444 CLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPC 503

Query: 66  CQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
             +G C      +QC+C  G+ G  C  D   C++ +PC NG +C+    G Y C C  G
Sbjct: 504 VNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS-TPCLNGAKCIDHPNG-YECQCATG 561

Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
           F G  CE     C+    PC +G QCQD      ++TC C  G++GA C   +D+C   P
Sbjct: 562 FTGVLCEENIDNCDP--DPCHHG-QCQDGID---SYTCICNPGYMGAICSDQIDECYSSP 615

Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
           C N   C+D +N + C C  G +G  C IN DDCAS PC  G  C D ++ + C+C  G+
Sbjct: 616 CLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGI-CMDGINRYSCVCSPGF 674

Query: 243 GGKTCEL 249
            G+ C +
Sbjct: 675 TGQRCNI 681



 Score =  156 bits (395), Expect = 3e-38
 Identities = 79/212 (37%), Positives = 108/212 (50%), Gaps = 18/212 (8%)

Query: 46  CRCDPGWEGLHC----ERCVRMPG--CQH-GTCHQP---WQCICHSGWAGKFCDKDEHIC 95
           C C  G++G  C    + C       C+H G C      + C C  G+AG  C+ D + C
Sbjct: 401 CTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINEC 460

Query: 96  TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFA 155
            +  PCQN   C+   GG + C+C+PGF G  CE +   C+   +PC N GQC D     
Sbjct: 461 HSD-PCQNDATCLDKIGG-FTCLCMPGFKGVHCELEINECQS--NPCVNNGQCVDKVN-- 514

Query: 156 LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
             F C C  GF G  C++++DDC   PC NGA C+D  N + C C  GF G  C  N+D+
Sbjct: 515 -RFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN 573

Query: 216 CASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
           C   PC  G +C+D +  + C+C  GY G  C
Sbjct: 574 CDPDPCHHG-QCQDGIDSYTCICNPGYMGAIC 604



 Score =  152 bits (385), Expect = 4e-37
 Identities = 83/240 (34%), Positives = 116/240 (48%), Gaps = 19/240 (7%)

Query: 27  DDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQ 76
           D+C S   L  G C        C C PG  G++CE     C   P C HG C      + 
Sbjct: 609 DECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP-CIHGICMDGINRYS 667

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
           C+C  G+ G+ C+ D   C + +PC+ G  C+ +G   + C+C  G H   C  +   C 
Sbjct: 668 CVCSPGFTGQRCNIDIDECAS-NPCRKGATCI-NGVNGFRCICPEGPHHPSCYSQVNEC- 724

Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
              +PC +G  C    G    + C C  G+VG  CEV+ ++CL  PC NG TC + +N +
Sbjct: 725 -LSNPCIHGN-CT---GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGY 779

Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
            C C +GF G  C +N+D+CAS PC     C D +  + C C   Y GK C+ VL    P
Sbjct: 780 RCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSP 839



 Score =  150 bits (378), Expect = 2e-36
 Identities = 88/292 (30%), Positives = 127/292 (43%), Gaps = 61/292 (20%)

Query: 14   LCILGAPGQPVRAD--DCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCER----CVRMP 64
            LC+ G  G   + D  +C S      G C+      +C+C  G++G+HCE     C    
Sbjct: 936  LCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESS 995

Query: 65   GCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
                GTC      + C+C  G+ G FC  + + C++  PC N G C+ DG G Y C C  
Sbjct: 996  CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSH-PCLNEGTCV-DGLGTYRCSCPL 1053

Query: 122  GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQ----------------------------- 152
            G+ G++C+     C +  SPC+N G C   +                             
Sbjct: 1054 GYTGKNCQTLVNLCSR--SPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASR 1111

Query: 153  ------------GFALN----FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
                        G  +N      C+C +G+ G+ CE  +D+C   PC +GATC D I  +
Sbjct: 1112 RGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGY 1171

Query: 197  SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
             C C  G+ G  C   +D+C ++PCQ G  C D V+ F C CP G  G  CE
Sbjct: 1172 RCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223



 Score =  142 bits (357), Expect = 7e-34
 Identities = 84/257 (32%), Positives = 114/257 (44%), Gaps = 28/257 (10%)

Query: 10  LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAP----DGSCRCDPGWEGLHCERCVRMPG 65
           L+ L     AP   ++  D    C +  G C       G C+C  G+ G +C+   R P 
Sbjct: 12  LLALWLCCAAPAHALQCRDGYEPC-VNEGMCVTYHNGTGYCKCPEGFLGEYCQH--RDP- 67

Query: 66  CQHGTCHQPWQCI-----------CHSGWAGKFCD-KDEHICTTQSPCQNGGQCMYDGGG 113
           C+   C     C+           C SG+ G+ C     H C    PC NGG C      
Sbjct: 68  CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD 127

Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
            Y C C  GF G++C+     C     PC NG  C      A  F+C+CL GF G +CE 
Sbjct: 128 TYECTCQVGFTGKECQ-WTDAC--LSHPCANGSTCTT---VANQFSCKCLTGFTGQKCET 181

Query: 174 NVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDR-V 231
           +V++C +   C +G TCL+    + C CP+GF G++C      CA  PC  G  CR    
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGD 241

Query: 232 HDFDCLCPSGYGGKTCE 248
             F+C C  G+ G TCE
Sbjct: 242 FTFECNCLPGFEGSTCE 258



 Score =  122 bits (306), Expect = 5e-28
 Identities = 93/301 (30%), Positives = 113/301 (37%), Gaps = 69/301 (22%)

Query: 15   CILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMP 64
            C LG  G     + D+C+S+    HG    D      C C PG++G++CE     C   P
Sbjct: 1137 CPLGYTGSYCEEQLDECASN-PCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQP 1195

Query: 65   GCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
                GTC      ++C C  G  G  C+++   C     C NGGQCM D  G Y C CLP
Sbjct: 1196 CQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCM-DRIGGYSCRCLP 1254

Query: 122  GFH----------------------------------------GRDCERKAGPCEQAGSP 141
            GF                                         GR CE     C Q   P
Sbjct: 1255 GFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQ--MP 1312

Query: 142  CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCP 201
            C NGG C         F CRC  GF GARC+     C    C  G  C+   +   C CP
Sbjct: 1313 CLNGGTCAVASNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCP 1369

Query: 202  EGFAGRFCTINLDDCASRPCQRGARCRDRVHD--FDCLCPSGYGGKTCEL-VLPVPDPPT 258
               + R C      CAS PCQ G  C  +     + C C   + G  CEL   P   PP 
Sbjct: 1370 ---SPRDCE---SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPA 1423

Query: 259  T 259
            T
Sbjct: 1424 T 1424



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 61/233 (26%), Positives = 85/233 (36%), Gaps = 23/233 (9%)

Query: 27   DDCSSHCDLAHGCCA-----PDGS-CRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICH 80
            D C     L  G CA     PDG  CRC PG+ G  C+       C    C +  QC+  
Sbjct: 1306 DVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQS-----SCGQVKCRKGEQCVHT 1360

Query: 81   SGWAGKFCD--KDEHICTTQSPCQNGGQCMYDGGGEYH-CVCLPGFHGRDCERKAGPCEQ 137
            +     FC   +D       SPCQ+GG C       Y+ C C P F G  CE    P   
Sbjct: 1361 ASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPST 1420

Query: 138  AGSPCRNGGQCQDDQGFALNFTCRC-LVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
              + C +       +    +  C      + G  C + +++     C++   C D IN  
Sbjct: 1421 PPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWAN-CSSPLPCWDYINN- 1478

Query: 197  SCLCPEGFAGRFCTINLDDCA--SRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
               C E      C  +  +C   S+ C+    C D  H  D  C  G   + C
Sbjct: 1479 --QCDELCNTVECLFDNFECQGNSKTCKYDKYCAD--HFKDNHCDQGCNSEEC 1527


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  194 bits (493), Expect = 1e-49
 Identities = 101/249 (40%), Positives = 126/249 (50%), Gaps = 20/249 (8%)

Query: 12   CLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRM 63
            CLL   GA  + V A    S C     C   +     SC C  GW+G  CE     CV  
Sbjct: 817  CLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLS 876

Query: 64   PGCQHGTC----HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC 119
            P C+HG      H  ++C C +G++G+ C+ D   C   +PC NGG C  DG     C C
Sbjct: 877  P-CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRP-NPCHNGGSCT-DGINTAFCDC 933

Query: 120  LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL 179
            LPGF G  CE     C  A  PCRNG  C D      ++TC C  GF G  CE N  DC 
Sbjct: 934  LPGFRGTFCEEDINEC--ASDPCRNGANCTDCVD---SYTCTCPAGFSGIHCENNTPDCT 988

Query: 180  MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCP 239
               C NG TC+DGIN F+CLCP GF G +C  ++++C S+PC  G  C+D    + C CP
Sbjct: 989  ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP 1048

Query: 240  SGYGGKTCE 248
             GY G  C+
Sbjct: 1049 QGYTGPNCQ 1057



 Score =  178 bits (452), Expect = 6e-45
 Identities = 93/286 (32%), Positives = 134/286 (46%), Gaps = 56/286 (19%)

Query: 15  CILGAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMP 64
           C+ G  GQ      DDC  +     G C  DG    +CRC P W G +C    + C  MP
Sbjct: 245 CLPGFTGQNCEENIDDCPGNNCKNGGACV-DGVNTYNCRCPPEWTGQYCTEDVDECQLMP 303

Query: 65  G-CQHG-TCHQP---WQCICHSGWAGKFCDKDEHICTT---------------------- 97
             CQ+G TCH     + C+C +GW G+ C ++   C +                      
Sbjct: 304 NACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPH 363

Query: 98  --------------QSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKAGPCEQAGSPC 142
                          +PC  G  C  +   G+  C C  G+ G  C +    C    +PC
Sbjct: 364 GRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423

Query: 143 RNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE 202
            + G+C +  G   +F C+CL G+ G RCE++V++C+  PC N ATCLD I  F C+C  
Sbjct: 424 EHAGKCINTLG---SFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP 480

Query: 203 GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
           G+ G  C +N D+CAS PC    RC D++++F C CP+G+ G  C+
Sbjct: 481 GYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQ 526



 Score =  172 bits (437), Expect = 3e-43
 Identities = 92/239 (38%), Positives = 124/239 (51%), Gaps = 20/239 (8%)

Query: 25  RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPG-CQHG-TCHQP- 74
           +AD C+S+     G C P  +   C C P + G  C +    C + PG C+HG TCH   
Sbjct: 140 QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV 199

Query: 75  --WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
             ++C+C +   G  C++    C+  SPCQNGG C   G   + C CLPGF G++CE   
Sbjct: 200 GSYRCVCRATHTGPNCERPYVPCSP-SPCQNGGTCRPTGDVTHECACLPGFTGQNCEENI 258

Query: 133 GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP--CANGATCL 190
             C   G+ C+NGG C D       + CRC   + G  C  +VD+C + P  C NG TC 
Sbjct: 259 DDCP--GNNCKNGGACVDGVN---TYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCH 313

Query: 191 DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
           +    ++C+C  G+ G  C+ N+DDCAS  C  GA C DRV  F C CP G  G  C L
Sbjct: 314 NTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHL 372



 Score =  171 bits (434), Expect = 8e-43
 Identities = 91/258 (35%), Positives = 125/258 (48%), Gaps = 22/258 (8%)

Query: 14  LCILGAPGQPV--RADDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHC---ERCVRMP 64
           +C+ G  G+      DDC+S     HG    D      C C  G  GL C   + C+  P
Sbjct: 322 VCVNGWTGEDCSENIDDCASAACF-HGATCHDRVASFYCECPHGRTGLLCHLNDACISNP 380

Query: 65  -----GCQHGTCHQPWQCICHSGWAGKFCDKDEHICTT-QSPCQNGGQCMYDGGGEYHCV 118
                 C     +    C C SG+ G  C +D   C+   +PC++ G+C+ +  G + C 
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCI-NTLGSFECQ 439

Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
           CL G+ G  CE     C    +PC+N   C D  G    F C C+ G+ G  CEVN D+C
Sbjct: 440 CLQGYTGPRCEIDVNEC--VSNPCQNDATCLDQIG---EFQCICMPGYEGVHCEVNTDEC 494

Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
              PC +   CLD IN F C CP GF G  C  ++D+CAS PC+ GA+C D  + + C+C
Sbjct: 495 ASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVC 554

Query: 239 PSGYGGKTCELVLPVPDP 256
             GY G  CE+ +   DP
Sbjct: 555 TEGYTGTHCEVDIDECDP 572



 Score =  171 bits (433), Expect = 1e-42
 Identities = 92/247 (37%), Positives = 122/247 (49%), Gaps = 21/247 (8%)

Query: 15  CILGAPGQPVRAD--DCSSH-CDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPG 65
           C+ G  G     D  +C S+ C     C    G   C C PG+EG+HCE     C   P 
Sbjct: 440 CLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPC 499

Query: 66  CQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
             +G C      +QC C +G+ G  C  D   C + +PC+NG +C+ DG   Y CVC  G
Sbjct: 500 LHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAS-TPCKNGAKCL-DGPNTYTCVCTEG 557

Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
           + G  CE     C+    PC  G  C+D       FTC C  G+ G  CE N+++C  +P
Sbjct: 558 YTGTHCEVDIDECDP--DPCHYGS-CKDG---VATFTCLCRPGYTGHHCETNINECSSQP 611

Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
           C +G TC D  N + C C +G  G  C INLDDCAS PC  G  C D++  ++C C  GY
Sbjct: 612 CRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGY 670

Query: 243 GGKTCEL 249
            G  C +
Sbjct: 671 TGSMCNI 677



 Score =  166 bits (421), Expect = 2e-41
 Identities = 95/259 (36%), Positives = 128/259 (49%), Gaps = 31/259 (11%)

Query: 5   CRCLH-LVCLLCILGAPGQPVRADDCSSH-CDLAHGCCAPDGS----CRCDPGWEGLHCE 58
           C C H    LLC L         D C S+ C+    C     +    C C  G+ G  C 
Sbjct: 359 CECPHGRTGLLCHLN--------DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACS 410

Query: 59  RCVRMPG-----CQH-GTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMY 109
           + V         C+H G C      ++C C  G+ G  C+ D + C + +PCQN   C+ 
Sbjct: 411 QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVS-NPCQNDATCL- 468

Query: 110 DGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGA 169
           D  GE+ C+C+PG+ G  CE     C  A SPC + G+C D       F C C  GF G 
Sbjct: 469 DQIGEFQCICMPGYEGVHCEVNTDEC--ASSPCLHNGRCLDKIN---EFQCECPTGFTGH 523

Query: 170 RCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
            C+ +VD+C   PC NGA CLDG N ++C+C EG+ G  C +++D+C   PC  G+ C+D
Sbjct: 524 LCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS-CKD 582

Query: 230 RVHDFDCLCPSGYGGKTCE 248
            V  F CLC  GY G  CE
Sbjct: 583 GVATFTCLCRPGYTGHHCE 601



 Score =  163 bits (413), Expect = 2e-40
 Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 20/237 (8%)

Query: 27  DDCS---SHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPGCQHGTCHQP--- 74
           D+CS   + C+ A  C    GS  C+C  G+ G  CE     CV  P     TC      
Sbjct: 414 DECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGE 473

Query: 75  WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
           +QCIC  G+ G  C+ +   C + SPC + G+C+ D   E+ C C  GF G  C+     
Sbjct: 474 FQCICMPGYEGVHCEVNTDECAS-SPCLHNGRCL-DKINEFQCECPTGFTGHLCQYDVDE 531

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C  A +PC+NG +C D       +TC C  G+ G  CEV++D+C   PC  G+ C DG+ 
Sbjct: 532 C--ASTPCKNGAKCLDGPN---TYTCVCTEGYTGTHCEVDIDECDPDPCHYGS-CKDGVA 585

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
            F+CLC  G+ G  C  N+++C+S+PC+ G  C+DR + + C C  G  G  CE+ L
Sbjct: 586 TFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINL 642



 Score =  159 bits (403), Expect = 3e-39
 Identities = 79/212 (37%), Positives = 111/212 (52%), Gaps = 16/212 (7%)

Query: 46  CRCDPGWEGLHCER---CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHICTTQS 99
           CRC PGW G  C++   C   P    G C      + C C   + G  C +D + C  Q 
Sbjct: 127 CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECG-QK 185

Query: 100 P--CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
           P  C++GG C ++  G Y CVC     G +CER   PC    SPC+NGG C+      + 
Sbjct: 186 PGLCRHGGTC-HNEVGSYRCVCRATHTGPNCERPYVPCSP--SPCQNGGTCRPTGD--VT 240

Query: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCA 217
             C CL GF G  CE N+DDC    C NG  C+DG+N ++C CP  + G++CT ++D+C 
Sbjct: 241 HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ 300

Query: 218 SRP--CQRGARCRDRVHDFDCLCPSGYGGKTC 247
             P  CQ G  C +    ++C+C +G+ G+ C
Sbjct: 301 LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332



 Score =  158 bits (400), Expect = 7e-39
 Identities = 87/249 (34%), Positives = 119/249 (47%), Gaps = 25/249 (10%)

Query: 28   DCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
            DC+       G C  DG    +C C PG+ G +C+     C   P    GTC      ++
Sbjct: 986  DCTESSCFNGGTCV-DGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYR 1044

Query: 77   CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
            C C  G+ G  C    H C + SPC+NGG+C +    +Y C C  G+ G  C+  +  CE
Sbjct: 1045 CTCPQGYTGPNCQNLVHWCDS-SPCKNGGKC-WQTHTQYRCECPSGWTGLYCDVPSVSCE 1102

Query: 137  QAGSP--------CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
             A           C++GG C D         CRC  G+ G+ CE  VD+C   PC NGAT
Sbjct: 1103 VAAQRQGVDVARLCQHGGLCVDAGN---THHCRCQAGYTGSYCEDLVDECSPSPCQNGAT 1159

Query: 189  CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            C D +  +SC C  G+ G  C+  +D+C S PCQ G  C D  + + C CP G  G  CE
Sbjct: 1160 CTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCE 1219

Query: 249  LVLPVPDPP 257
            + +   +PP
Sbjct: 1220 INVDDCNPP 1228



 Score =  151 bits (381), Expect = 1e-36
 Identities = 83/248 (33%), Positives = 117/248 (47%), Gaps = 21/248 (8%)

Query: 15  CILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG-SCRCDPGWEGLHC----ERCVRMPGC 66
           C+ G  G    +  DDC SS CD        DG  C C+PG+ G  C    + C   P  
Sbjct: 629 CLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCH 688

Query: 67  QHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
             GTC      + C C  G+    C  + + C + +PC +G     D    Y C C PG+
Sbjct: 689 NGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNS-NPCVHGA--CRDSLNGYKCDCDPGW 745

Query: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC 183
            G +C+     CE   +PC NGG C+D       + C C  GF G  C+ N+++C   PC
Sbjct: 746 SGTNCDINNNECES--NPCVNGGTCKD---MTSGYVCTCREGFSGPNCQTNINECASNPC 800

Query: 184 ANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR--DRVHDFDCLCPSG 241
            N  TC+D +  + C C   + G  C + L  CA  PC+ G  CR  +    F C+CP+G
Sbjct: 801 LNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860

Query: 242 YGGKTCEL 249
           + G+TCE+
Sbjct: 861 WQGQTCEV 868



 Score =  149 bits (375), Expect = 5e-36
 Identities = 98/298 (32%), Positives = 129/298 (43%), Gaps = 55/298 (18%)

Query: 3   SGCRCL---HLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGL 55
           +G +CL   +    +C  G  G     D      D  H     DG    +C C PG+ G 
Sbjct: 539 NGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGH 598

Query: 56  HCE----RCVRMPGCQHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
           HCE     C   P C+HG TC      + C C  G  G  C+ +   C + SPC +G  C
Sbjct: 599 HCETNINECSSQP-CRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCAS-SPCDSG-TC 655

Query: 108 MYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD-QGF------------ 154
           +    G Y C C PG+ G  C      C  AG+PC NGG C+D   GF            
Sbjct: 656 LDKIDG-YECACEPGYTGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCRCPEGYHDPT 712

Query: 155 --------------------ALN-FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
                               +LN + C C  G+ G  C++N ++C   PC NG TC D  
Sbjct: 713 CLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMT 772

Query: 194 NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
           + + C C EGF+G  C  N+++CAS PC     C D V  + C C   Y G TCE+VL
Sbjct: 773 SGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVL 830



 Score =  146 bits (369), Expect = 3e-35
 Identities = 93/268 (34%), Positives = 121/268 (45%), Gaps = 34/268 (12%)

Query: 38   GCCAPDGS---CRCDPGWEGLHCE----RCVRMPGCQHG-TCHQ---PWQCICHSGWAGK 86
            G C   G+   CRC  G+ G +CE     C   P CQ+G TC      + C C +G+ G 
Sbjct: 1120 GLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSP-CQNGATCTDYLGGYSCKCVAGYHGV 1178

Query: 87   FCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP----- 141
             C ++   C +  PCQNGG C+ D    Y C C  G  G  CE     C     P     
Sbjct: 1179 NCSEEIDECLSH-PCQNGGTCL-DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP 1236

Query: 142  -CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT--CLDGINRFSC 198
             C N G C D  G    ++C C  GFVG RCE +V++CL  PC    T  C+  +N F C
Sbjct: 1237 KCFNNGTCVDQVG---GYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHC 1293

Query: 199  LCPEGFAGRFCTINLDDCASRPCQRGARCR---DRVHDFDCLCPSGYGGKTCEL------ 249
             C  G  GR C   ++ C  +PC+ G  C    +    F C CP+G+ G TCE       
Sbjct: 1294 ECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCG 1353

Query: 250  VLPVPDPPTTVDTPLGPTSAVVVPATGP 277
             L   +  T +  P  PT   + P TGP
Sbjct: 1354 SLRCLNGGTCISGPRSPTCLCLGPFTGP 1381



 Score =  133 bits (334), Expect = 3e-31
 Identities = 86/260 (33%), Positives = 119/260 (45%), Gaps = 30/260 (11%)

Query: 10  LVCLLCILGAPGQPVRADDCSSH---CDLAHGCCAPDGS--CRCDPGWEGLHCER---CV 61
           L  LLC+   P    R   CS     C     C A +G+  C C   + G  C+    C+
Sbjct: 5   LAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCL 64

Query: 62  RMPGCQHGTCH-------QPWQCICHSGWAGKFCDKD-EHICTTQSPCQNGGQCMYDGGG 113
             P    GTCH         + C C  G++G  C    ++ C T +PC+NGG C      
Sbjct: 65  STPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLT-NPCRNGGTCDLLTLT 123

Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
           EY C C PG+ G+ C+ +A PC  A +PC NGGQC     F  ++ C C   F G  C  
Sbjct: 124 EYKCRCPPGWSGKSCQ-QADPC--ASNPCANGGQCLP---FEASYICHCPPSFHGPTCRQ 177

Query: 174 NVDDCLMRP--CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR--- 228
           +V++C  +P  C +G TC + +  + C+C     G  C      C+  PCQ G  CR   
Sbjct: 178 DVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG 237

Query: 229 DRVHDFDCLCPSGYGGKTCE 248
           D  H  +C C  G+ G+ CE
Sbjct: 238 DVTH--ECACLPGFTGQNCE 255



 Score =  127 bits (318), Expect = 2e-29
 Identities = 82/251 (32%), Positives = 108/251 (43%), Gaps = 34/251 (13%)

Query: 27   DDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCERCV-----------RMPGC-QHGTC 71
            D+C SH     G C        C C  G +G+HCE  V           R P C  +GTC
Sbjct: 1185 DECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTC 1244

Query: 72   HQP---WQCICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRD 127
                  + C C  G+ G+ C+ D + C + +PC   G Q       ++HC C  G  GR 
Sbjct: 1245 VDQVGGYSCTCPPGFVGERCEGDVNECLS-NPCDARGTQNCVQRVNDFHCECRAGHTGRR 1303

Query: 128  CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGA 187
            CE     C+  G PC+NGG C      A  F C+C  GF GA CE +   C    C NG 
Sbjct: 1304 CESVINGCK--GKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGG 1361

Query: 188  TCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDR--------VHDFDCLCP 239
            TC+ G    +CLC   F G  C       AS PC  G  C ++           + CLCP
Sbjct: 1362 TCISGPRSPTCLCLGPFTGPECQFP----ASSPCLGGNPCYNQGTCEPTSESPFYRCLCP 1417

Query: 240  SGYGGKTCELV 250
            + + G  C ++
Sbjct: 1418 AKFNGLLCHIL 1428



 Score =  120 bits (302), Expect = 2e-27
 Identities = 81/248 (32%), Positives = 104/248 (41%), Gaps = 24/248 (9%)

Query: 27   DDCS-SHCDLAHGCCAPDG--SCRCDPGWEGLHC----ERCVRMPGCQHGTC---HQPWQ 76
            D+CS S C     C    G  SC+C  G+ G++C    + C+  P    GTC      ++
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYK 1206

Query: 77   CICHSGWAGKFCDKDEHICT------TQSP-CQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
            C C  G  G  C+ +   C       ++SP C N G C+   GG Y C C PGF G  CE
Sbjct: 1207 CSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGG-YSCTCPPGFVGERCE 1265

Query: 130  RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
                 C    +PC   G  Q+      +F C C  G  G RCE  ++ C  +PC NG TC
Sbjct: 1266 GDVNEC--LSNPCDARGT-QNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTC 1322

Query: 190  LDGINR---FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKT 246
                N    F C CP GF G  C  +   C S  C  G  C        CLC   + G  
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPE 1382

Query: 247  CELVLPVP 254
            C+     P
Sbjct: 1383 CQFPASSP 1390



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 48/132 (36%), Positives = 66/132 (50%), Gaps = 11/132 (8%)

Query: 133 GP-CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC-- 189
           GP C Q G  C NGG+C+   G      C C   FVG RC+ + + CL  PC N  TC  
Sbjct: 21  GPRCSQPGETCLNGGKCEAANGTE---ACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHV 76

Query: 190 --LDGINRFSCLCPEGFAGRFCTINLDD-CASRPCQRGARCRD-RVHDFDCLCPSGYGGK 245
               G+  ++C C  GF+G  C   LD+ C + PC+ G  C    + ++ C CP G+ GK
Sbjct: 77  VDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGK 136

Query: 246 TCELVLPVPDPP 257
           +C+   P    P
Sbjct: 137 SCQQADPCASNP 148


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  186 bits (471), Expect = 4e-47
 Identities = 99/287 (34%), Positives = 134/287 (46%), Gaps = 56/287 (19%)

Query: 15  CILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMP 64
           C+ G  GQ   V  DDC  H  L  G C  DG    +C+C P W G  C    + C   P
Sbjct: 224 CLPGFEGQNCEVNVDDCPGHRCLNGGTCV-DGVNTYNCQCPPEWTGQFCTEDVDECQLQP 282

Query: 65  GCQH--GTCHQPW---QCICHSGWAGKFCDKDEHICTT---------------------- 97
              H  GTC        C+C +GW G+ C ++   C T                      
Sbjct: 283 NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPM 342

Query: 98  --------------QSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKAGPCEQAGSPC 142
                          +PC     C  +   G   C C PGF G  C++    C    +PC
Sbjct: 343 GKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPC 402

Query: 143 RNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE 202
            + G+C + QG   +F C+C  G+ G RCE +V++CL  PC N ATCLD I +F+C+C  
Sbjct: 403 EHLGRCVNTQG---SFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459

Query: 203 GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
           GF G +C +++D+C S PC  G  C+DRV+ F C CPSG+ G TC+L
Sbjct: 460 GFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL 506



 Score =  175 bits (443), Expect = 7e-44
 Identities = 101/262 (38%), Positives = 126/262 (48%), Gaps = 29/262 (11%)

Query: 2   PSGCRCLHLVCLLCILGAPG----QPVRADDCSSHCDLAHGCCAPDG---SCRCDPGWEG 54
           P G RC+      C  G  G    Q +  D C S    A G C+ DG    C C PG +G
Sbjct: 713 PGGFRCV------CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQG 766

Query: 55  LHCE---RCVRMPGCQH-GTCHQ-PWQ---CICHSGWAGKFCDKDEHICTTQSPCQNGGQ 106
             CE    C   P C+H G C   P Q   C C  GW G  C +D   C   +PC   G 
Sbjct: 767 RQCELLSPCTPNP-CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI 825

Query: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
           C  +  G + C C  G+ G  C++    C+   +PC NGG CQD  G   +F+C CL GF
Sbjct: 826 CT-NLAGSFSCTCHGGYTGPSCDQDINDCDP--NPCLNGGSCQDGVG---SFSCSCLPGF 879

Query: 167 VGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGAR 226
            G RC  +VD+CL  PC  G TC D +  F+C CP G+ G  C  +L DC+   C  G  
Sbjct: 880 AGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT 938

Query: 227 CRDRVHDFDCLCPSGYGGKTCE 248
           C D V+ F CLC  GY G  C+
Sbjct: 939 CVDGVNSFSCLCRPGYTGAHCQ 960



 Score =  174 bits (441), Expect = 1e-43
 Identities = 99/267 (37%), Positives = 134/267 (50%), Gaps = 28/267 (10%)

Query: 3   SGCRCLHL----VCLLCILGAPGQPVRADD-CSSHCDLAHGCCAPDG-------SCRCDP 50
           +G RC  L       LC  G  G+  + +D C S      G C           SCRC  
Sbjct: 51  NGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPR 110

Query: 51  GWEGLHC---ERCVRMPGCQHGT-CHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQ 102
           G+ G  C   + C+  P C HG  C       + C C  G+ G+ C  D   C    PC+
Sbjct: 111 GFRGPDCSLPDPCLSSP-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCR 169

Query: 103 NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRC 162
           +GG C+ +  G + C C  G+ G  CE  A PC  A SPCRNGG C+  Q   L + C C
Sbjct: 170 HGGTCL-NTPGSFRCQCPAGYTGPLCENPAVPC--APSPCRNGGTCR--QSGDLTYDCAC 224

Query: 163 LVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP-- 220
           L GF G  CEVNVDDC    C NG TC+DG+N ++C CP  + G+FCT ++D+C  +P  
Sbjct: 225 LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA 284

Query: 221 CQRGARCRDRVHDFDCLCPSGYGGKTC 247
           C  G  C + +    C+C +G+ G++C
Sbjct: 285 CHNGGTCFNTLGGHSCVCVNGWTGESC 311



 Score =  166 bits (421), Expect = 2e-41
 Identities = 90/250 (36%), Positives = 125/250 (50%), Gaps = 22/250 (8%)

Query: 14  LCILGAPGQPV--RADDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHC---ERCVRMP 64
           +C+ G  G+      DDC++     HG    D      C C  G  GL C   + CV  P
Sbjct: 301 VCVNGWTGESCSQNIDDCATAVCF-HGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP 359

Query: 65  GCQHGTCH-QPWQ----CICHSGWAGKFCDKDEHICTT-QSPCQNGGQCMYDGGGEYHCV 118
             +   C   P      C C  G+ G  CD+D   C+   +PC++ G+C+ +  G + C 
Sbjct: 360 CHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV-NTQGSFLCQ 418

Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
           C  G+ G  CE     C     PCRN   C D  G    FTC C+ GF G  CEV++D+C
Sbjct: 419 CGRGYTGPRCETDVNEC--LSGPCRNQATCLDRIG---QFTCICMAGFTGTYCEVDIDEC 473

Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
              PC NG  C D +N FSC CP GF+G  C +++D+CAS PC+ GA+C D+   ++C C
Sbjct: 474 QSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRC 533

Query: 239 PSGYGGKTCE 248
             G+ G  C+
Sbjct: 534 AEGFEGTLCD 543



 Score =  164 bits (416), Expect = 9e-41
 Identities = 103/323 (31%), Positives = 144/323 (44%), Gaps = 67/323 (20%)

Query: 18  GAPGQPVRADDCS---SHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPGCQH 68
           GA  Q V  D+CS   + C+    C    GS  C+C  G+ G  CE     C+  P    
Sbjct: 386 GACDQDV--DECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ 443

Query: 69  GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
            TC      + CIC +G+ G +C+ D   C + SPC NGG C  D    + C C  GF G
Sbjct: 444 ATCLDRIGQFTCICMAGFTGTYCEVDIDECQS-SPCVNGGVCK-DRVNGFSCTCPSGFSG 501

Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDD---------QGFA--------------------- 155
             C+     C  A +PCRNG +C D          +GF                      
Sbjct: 502 STCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRC 559

Query: 156 ----LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTI 211
                +F+C C  G+ G RCE  VD+C  +PC +G  CLD ++++ C CP G  G  C +
Sbjct: 560 VDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619

Query: 212 NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL------PVPDPPTTVD---- 261
           N+DDCAS PC  G  CRD ++ +DC+C  G+ G  C + +      P  +  + VD    
Sbjct: 620 NIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENG 678

Query: 262 ----TPLGPTSAVVVPATGPAPH 280
                P G    + +P + P  H
Sbjct: 679 FRCLCPPGSLPPLCLPPSHPCAH 701



 Score =  164 bits (416), Expect = 9e-41
 Identities = 111/345 (32%), Positives = 142/345 (41%), Gaps = 100/345 (28%)

Query: 4   GCRCLHLV---CLLCILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEG 54
           G +CL LV      C  G  G    V  DDC+S+     G C  DG     C C PG+ G
Sbjct: 594 GGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN-PCTFGVCR-DGINRYDCVCQPGFTG 651

Query: 55  LHCE------------------------RCVRMPG-----------------CQHGTCHQ 73
             C                         RC+  PG                 C HG C+ 
Sbjct: 652 PLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYD 711

Query: 74  P---WQCICHSGWAGKFCDKD--EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
               ++C+C  GW+G  C +      C +Q PC+ GG C  DG G +HC C PG  GR C
Sbjct: 712 APGGFRCVCEPGWSGPRCSQSLARDACESQ-PCRAGGTCSSDGMG-FHCTCPPGVQGRQC 769

Query: 129 ERKAGPCEQAGSPCRNGGQCQDDQG----------------------------------- 153
           E  + PC    +PC +GG+C+   G                                   
Sbjct: 770 ELLS-PCTP--NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826

Query: 154 --FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTI 211
              A +F+C C  G+ G  C+ +++DC   PC NG +C DG+  FSC C  GFAG  C  
Sbjct: 827 TNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886

Query: 212 NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
           ++D+C S PC  G  C D V  F C CP GYGG  CE  LP   P
Sbjct: 887 DVDECLSNPCGPGT-CTDHVASFTCTCPPGYGGFHCEQDLPDCSP 930



 Score =  161 bits (408), Expect = 8e-40
 Identities = 88/241 (36%), Positives = 120/241 (49%), Gaps = 27/241 (11%)

Query: 28   DCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQ 76
            DCS       G C  DG    SC C PG+ G HC+     C+  P    G C   H  ++
Sbjct: 927  DCSPSSCFNGGTCV-DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFR 985

Query: 77   CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
            C C   + G  C      C+ Q PCQNGG+C+  G    +C+C PG+ GR C+ ++ PC 
Sbjct: 986  CTCLESFTGPQCQTLVDWCSRQ-PCQNGGRCVQTGA---YCLCPPGWSGRLCDIRSLPCR 1041

Query: 137  QAGSP--------CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
            +A +         C+ GGQC D+     +  C C  G  G+ CE  VD CL +PC +G T
Sbjct: 1042 EAAAQIGVRLEQLCQAGGQCVDEDS---SHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGT 1098

Query: 189  CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            C   +  + C C  G+ G  C  ++D+CAS+PCQ G  C D V  + C CP G  G  CE
Sbjct: 1099 CRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158

Query: 249  L 249
            +
Sbjct: 1159 I 1159



 Score =  159 bits (403), Expect = 3e-39
 Identities = 89/247 (36%), Positives = 115/247 (46%), Gaps = 30/247 (12%)

Query: 26   ADDCSSHCDLAHGCCA---PDGSCRCDPGWEGLHCER----CVRMPGCQHGTCHQPWQ-C 77
            AD C S   L  G C+   P   C C   + G  C+     C R P    G C Q    C
Sbjct: 963  ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYC 1022

Query: 78   ICHSGWAGKFCDKDEHICTTQSP---------CQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
            +C  GW+G+ CD     C   +          CQ GGQC+ D    ++CVC  G  G  C
Sbjct: 1023 LCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCV-DEDSSHYCVCPEGRTGSHC 1081

Query: 129  ERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
            E++  PC     PC++GG C+   G+   + C CL G+ G  CE +VD+C  +PC +G +
Sbjct: 1082 EQEVDPC--LAQPCQHGGTCR---GYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGS 1136

Query: 189  CLDGINRFSCLCPEGFAGRFCTINLDDCASRP-------CQRGARCRDRVHDFDCLCPSG 241
            C+D + R+ C CP G  G  C IN DDC   P       C     C D V  F C CP G
Sbjct: 1137 CIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPG 1196

Query: 242  YGGKTCE 248
            Y G  CE
Sbjct: 1197 YTGLRCE 1203



 Score =  139 bits (349), Expect = 6e-33
 Identities = 84/231 (36%), Positives = 108/231 (46%), Gaps = 20/231 (8%)

Query: 27  DDCSSH-CDLAHGCC-APDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
           D+C+S  C     C   PDG  CRC  G+EG  C+R    C   P C HG C      + 
Sbjct: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDP-CHHGRCVDGIASFS 567

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
           C C  G+ G  C+     C +Q PC++GG+C+ D   +Y C C  G  G +CE     C 
Sbjct: 568 CACAPGYTGTRCESQVDECRSQ-PCRHGGKCL-DLVDKYLCRCPSGTTGVNCEVNIDDC- 624

Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
            A +PC   G C+D       + C C  GF G  C V +++C   PC  G +C+DG N F
Sbjct: 625 -ASNPC-TFGVCRDGIN---RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 679

Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
            CLCP G     C      CA  PC  G  C D    F C+C  G+ G  C
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRC 729



 Score =  135 bits (340), Expect = 6e-32
 Identities = 98/278 (35%), Positives = 120/278 (43%), Gaps = 35/278 (12%)

Query: 33   CDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMPGCQHG-TCHQ---PWQCICHSG 82
            C     C   D S  C C  G  G HCE+    C+  P CQHG TC      + C C  G
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQP-CQHGGTCRGYMGGYMCECLPG 1113

Query: 83   WAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA-----GPCEQ 137
            + G  C+ D   C +Q PCQ+GG C+ D    Y C C PG  G  CE        GP   
Sbjct: 1114 YNGDNCEDDVDECASQ-PCQHGGSCI-DLVARYLCSCPPGTLGVLCEINEDDCGPGPPLD 1171

Query: 138  AGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC--ANGATCL-DGIN 194
            +G  C + G C D  G    F C C  G+ G RCE ++++C    C  A+   CL D   
Sbjct: 1172 SGPRCLHNGTCVDLVG---GFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG 1228

Query: 195  RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-----DFDCLCPSGYGGKTCEL 249
             F CLC  GF+G  C   L  C S+PCQ G +CR          F C C   + G  CE 
Sbjct: 1229 GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288

Query: 250  V------LPVPDPPTTVDTPLGPTSAVVVPATGPAPHS 281
            V      L  P       TP GP  A     +GP+  S
Sbjct: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326



 Score =  128 bits (322), Expect = 8e-30
 Identities = 78/229 (34%), Positives = 105/229 (45%), Gaps = 27/229 (11%)

Query: 38  GCCAPDGS----CRCDPGWEGLHCE---------RCVRMPGCQHGTCHQPWQCICHSGWA 84
           G C   G     C C PG+EG +CE         RC+    C  G     + C C   W 
Sbjct: 210 GTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGV--NTYNCQCPPEWT 267

Query: 85  GKFCDKDEHICTTQ-SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
           G+FC +D   C  Q + C NGG C    GG + CVC+ G+ G  C +    C  A + C 
Sbjct: 268 GQFCTEDVDECQLQPNACHNGGTCFNTLGG-HSCVCVNGWTGESCSQNIDDC--ATAVCF 324

Query: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC-LDGIN-RFSCLCP 201
           +G  C D      +F C C +G  G  C ++ D C+  PC   A C  + +N R  C CP
Sbjct: 325 HGATCHDR---VASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCP 380

Query: 202 EGFAGRFCTINLDDCA--SRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            GF G  C  ++D+C+  + PC+   RC +    F C C  GY G  CE
Sbjct: 381 PGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429



 Score =  121 bits (304), Expect = 9e-28
 Identities = 64/157 (40%), Positives = 80/157 (50%), Gaps = 7/157 (4%)

Query: 95  CTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD-QG 153
           C   SPC NGG+C      E  C+C PG+ G  C+ +  PC     PC   G CQ     
Sbjct: 43  CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCH--SGPCAGRGVCQSSVVA 99

Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN-RFSCLCPEGFAGRFCTIN 212
               F+CRC  GF G  C +  D CL  PCA+GA C  G + RF C CP G+ GR C  +
Sbjct: 100 GTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158

Query: 213 LDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
           +D+C    PC+ G  C +    F C CP+GY G  CE
Sbjct: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195



 Score =  118 bits (295), Expect = 1e-26
 Identities = 80/259 (30%), Positives = 104/259 (40%), Gaps = 32/259 (12%)

Query: 27   DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCE----------RCVRMPGCQH-GTCH 72
            D+C+S      G C    +   C C PG  G+ CE               P C H GTC 
Sbjct: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183

Query: 73   Q---PWQCICHSGWAGKFCDKDEHICTTQS-PCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
                 ++C C  G+ G  C+ D + C + +    +   C+ D GG + C+C  GF G  C
Sbjct: 1184 DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243

Query: 129  ERKAGPCEQAGSPCRNGGQCQDDQG--FALNFTCRCLVGFVGARCEVNVDDCLMRPCANG 186
            +    PCE    PC++GGQC+   G    L FTC C   F G RCE     C    C  G
Sbjct: 1244 QTVLSPCES--QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVG 1301

Query: 187  ATCLDGINRFSCLCPEGFAGRFCT--------INLDDCASRPCQRGARCRDR--VHDFDC 236
              C        C CP G +G  C          +   CA+ PC  G  CR       F C
Sbjct: 1302 VPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRC 1361

Query: 237  LCPSGYGGKTCELVLPVPD 255
             C  G+ G  CE     P+
Sbjct: 1362 ACAQGWTGPRCEAPAAAPE 1380



 Score =  116 bits (291), Expect = 3e-26
 Identities = 65/196 (33%), Positives = 88/196 (44%), Gaps = 19/196 (9%)

Query: 59  RCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYD---GGGEY 115
           RC ++P  +         C+C  GW G+ C  ++   +   PC   G C      G   +
Sbjct: 54  RCTQLPSREAA-------CLCPPGWVGERCQLEDPCHS--GPCAGRGVCQSSVVAGTARF 104

Query: 116 HCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
            C C  GF G DC     PC    SPC +G +C    G    F C C  G+ G  C  +V
Sbjct: 105 SCRCPRGFRGPDCSLP-DPC--LSSPCAHGARCS--VGPDGRFLCSCPPGYQGRSCRSDV 159

Query: 176 DDCLM-RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-D 233
           D+C +  PC +G TCL+    F C CP G+ G  C      CA  PC+ G  CR      
Sbjct: 160 DECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT 219

Query: 234 FDCLCPSGYGGKTCEL 249
           +DC C  G+ G+ CE+
Sbjct: 220 YDCACLPGFEGQNCEV 235



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 32/80 (40%), Positives = 38/80 (47%), Gaps = 10/80 (12%)

Query: 182 PCANGATCLDGINR-FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV----HDFDC 236
           PCANG  C    +R  +CLCP G+ G  C +  D C S PC     C+  V      F C
Sbjct: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFSC 106

Query: 237 LCPSGYGGKTCELVLPVPDP 256
            CP G+ G  C L    PDP
Sbjct: 107 RCPRGFRGPDCSL----PDP 122



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 82/343 (23%), Positives = 109/343 (31%), Gaps = 98/343 (28%)

Query: 1    MPSGCRCLHL-VCL--------LCILGAPGQPVRAD--DC-SSHCDLAH--GCCAPDGS- 45
            + SG RCLH   C+         C  G  G    AD  +C S  C  AH   C    G  
Sbjct: 1170 LDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGG 1229

Query: 46   --CRCDPGWEGLHCER----CVRMPGCQHG---------------TCH--QPW------- 75
              C C  G+ G  C+     C   P CQHG               TCH  QP+       
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQP-CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288

Query: 76   -----------------------QCICHSGWAGKFCDK-------DEHICTTQSPCQNGG 105
                                   +C C  G +G  C           +     +PC +GG
Sbjct: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG 1348

Query: 106  QCMYDGGGEY-HCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG-FALNFTCRCL 163
             C       +  C C  G+ G  CE  A   E +  P      CQ  +G    +  C   
Sbjct: 1349 SCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSP 1408

Query: 164  -VGFVGARCEVNVDD----CLMRPC---ANGATCLDGINRFSCL-----CPEGFAGRFCT 210
              G+ G  C ++V D    C    C    N + C    +  +CL     C  G   R C 
Sbjct: 1409 GCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN 1468

Query: 211  -INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLP 252
             +    CA        RC    +  +C    G+ G  C   +P
Sbjct: 1469 PVYEKYCADHFAD--GRCDQGCNTEEC----GWDGLDCASEVP 1505



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 1/39 (2%)

Query: 220 PCQRGARCRDRV-HDFDCLCPSGYGGKTCELVLPVPDPP 257
           PC  G RC      +  CLCP G+ G+ C+L  P    P
Sbjct: 48  PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP 86


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  185 bits (470), Expect = 5e-47
 Identities = 87/210 (41%), Positives = 118/210 (56%), Gaps = 14/210 (6%)

Query: 46   CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQ 98
            C C  G+ GL CE     C  +P   +G C      + C C SG+ G+ C+++ + C++ 
Sbjct: 1217 CLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSS- 1275

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            SPC N G C+ DG   Y C C+ GF G  CE +   C+   +PC N   C+D  G    F
Sbjct: 1276 SPCLNKGICV-DGVAGYRCTCVKGFVGLHCETEVNECQS--NPCLNNAVCEDQVG---GF 1329

Query: 159  TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
             C+C  GF+G RC  NVD+CL +PC NGATC DG N F CLC  GF G  C +N+++C S
Sbjct: 1330 LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389

Query: 219  RPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
             PC+  A C D ++ + C C  G+ GK CE
Sbjct: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419



 Score =  157 bits (396), Expect = 2e-38
 Identities = 78/193 (40%), Positives = 100/193 (51%), Gaps = 10/193 (5%)

Query: 60   CVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
            C   P    GTC Q    + C+C  G+ G  C+ D   C+   PC N G C  D  GE+ 
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPL-PCLNNGVCK-DLVGEFI 1254

Query: 117  CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
            C C  G+ G+ CE     C  + SPC N G C D       + C C+ GFVG  CE  V+
Sbjct: 1255 CECPSGYTGQRCEENINEC--SSSPCLNKGICVDG---VAGYRCTCVKGFVGLHCETEVN 1309

Query: 177  DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
            +C   PC N A C D +  F C CP GF G  C  N+D+C S+PC+ GA C+D  + F C
Sbjct: 1310 ECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369

Query: 237  LCPSGYGGKTCEL 249
            LC +G+ G  CEL
Sbjct: 1370 LCAAGFTGSHCEL 1382



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 3/88 (3%)

Query: 164  VGFVGARCEVNVD---DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP 220
            +G +  R E++     +C   PC N  TC      + CLCP G+ G  C  ++D+C+  P
Sbjct: 1180 LGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP 1239

Query: 221  CQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            C     C+D V +F C CPSGY G+ CE
Sbjct: 1240 CLNNGVCKDLVGEFICECPSGYTGQRCE 1267



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 37/96 (38%), Positives = 45/96 (46%), Gaps = 11/96 (11%)

Query: 38   GCCAPDGSCRCDPGWEGLHCER--CVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHIC 95
            G C    +C C  GW G  CE   C+ +P    G C  P+QC C  GW G  C    H  
Sbjct: 3480 GICQRPNACSCPEGWMGRLCEEPICI-LPCLNGGRCVAPYQCDCPPGWTGSRC----HTA 3534

Query: 96   TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERK 131
              QSPC NGG+C+        C CL  + G +C RK
Sbjct: 3535 VCQSPCLNGGKCVRPN----RCHCLSSWTGHNCSRK 3566



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 41/115 (35%), Positives = 50/115 (43%), Gaps = 19/115 (16%)

Query: 57   CERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
            C    R P    G C +P  C C  GW G+ C  +E IC    PC NGG+C+      Y 
Sbjct: 3468 CRAVCRFPCQNGGICQRPNACSCPEGWMGRLC--EEPICIL--PCLNGGRCV----APYQ 3519

Query: 117  CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
            C C PG+ G  C      C+   SPC NGG+C           C CL  + G  C
Sbjct: 3520 CDCPPGWTGSRCH--TAVCQ---SPCLNGGKCVRPN------RCHCLSSWTGHNC 3563



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 36/111 (32%), Positives = 44/111 (39%), Gaps = 21/111 (18%)

Query: 100  PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
            PCQNGG C         C C  G+ GR CE           PC NGG+C         + 
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPI-----CILPCLNGGRC------VAPYQ 3519

Query: 160  CRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
            C C  G+ G+RC   V      PC NG  C   +    C C   + G  C+
Sbjct: 3520 CDCPPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCS 3564



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 9/66 (13%)

Query: 182  PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
            PC NG  C       +C CPEG+ GR C    +     PC  G RC   V  + C CP G
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPG 3525

Query: 242  YGGKTC 247
            + G  C
Sbjct: 3526 WTGSRC 3531



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 2/77 (2%)

Query: 15   CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQH-GTCHQ 73
            C  G  G+      C   C L  G C     C C PGW G  C   V    C + G C +
Sbjct: 3490 CPEGWMGRLCEEPICILPC-LNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVR 3548

Query: 74   PWQCICHSGWAGKFCDK 90
            P +C C S W G  C +
Sbjct: 3549 PNRCHCLSSWTGHNCSR 3565



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 44/155 (28%), Positives = 55/155 (35%), Gaps = 25/155 (16%)

Query: 32  HCDLAHGCCAPDGSCRCDPGW-EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDK 90
           H DL  G    D    C     EG  C  C RM  C+ GT    ++CIC  G+ GK    
Sbjct: 261 HEDLPSGSFIQDDMVHCSYLCDEGKDC--CDRMGSCKCGTHTGHFECICEKGYYGKGLQY 318

Query: 91  DEHICTTQS--------------PCQNGGQCMYDGG-GEYHCVCLPGFH--GRDCERKAG 133
           +   C + +              PC +       G      CVC  G+   G+ CE    
Sbjct: 319 ECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378

Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTC--RCLVGF 166
           P   A  P  NG   Q+      N  C  RC  GF
Sbjct: 379 P---ALKPPENGYFIQNTCNNHFNAACGVRCHPGF 410



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 32/115 (27%), Positives = 43/115 (37%), Gaps = 21/115 (18%)

Query: 27   DDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---W 75
            D+C S     +G    DG+    C C  G+ G HCE     C   P     TC      +
Sbjct: 1347 DECLSQ-PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSY 1405

Query: 76   QCICHSGWAGKFCDKDEHICTTQSPCQNG--GQCMYDGGGEYHCVCLPGFHGRDC 128
             C C  G++GK C+ ++          +G  G  M DG        LP  H   C
Sbjct: 1406 SCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDG-------MLPSLHALTC 1453



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 29/104 (27%)

Query: 183 CANGATCLDGIN---------RFSCLCPEGFAGRFCTINLDDCASRPCQRGAR------- 226
           C  G  C D +           F C+C +G+ G+        C S   +           
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340

Query: 227 --CRDRVHDF--------DCLCPSGY--GGKTCELV-LPVPDPP 257
             C D  H          DC+C  GY   G+TCELV  P   PP
Sbjct: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPP 384



 Score = 29.6 bits (65), Expect = 4.8
 Identities = 18/61 (29%), Positives = 24/61 (39%), Gaps = 12/61 (19%)

Query: 185 NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGG 244
           +G+   D +   S LC EG           DC  R      +C      F+C+C  GY G
Sbjct: 266 SGSFIQDDMVHCSYLCDEG----------KDCCDR--MGSCKCGTHTGHFECICEKGYYG 313

Query: 245 K 245
           K
Sbjct: 314 K 314



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 11/77 (14%)

Query: 220  PCQRGARCRDRVHDFDCLCPSGYGGKTCE---LVLPVPD-----PPTTVDTPLGPTSAVV 271
            PCQ G  C+       C CP G+ G+ CE    +LP  +      P   D P G T +  
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC 3531

Query: 272  VPATGPAPHSAGAGLLR 288
              A   +P   G   +R
Sbjct: 3532 HTAVCQSPCLNGGKCVR 3548


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  184 bits (468), Expect = 9e-47
 Identities = 95/240 (39%), Positives = 129/240 (53%), Gaps = 20/240 (8%)

Query: 27  DDCSSH-CDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMPG---CQHG-TCHQPW-- 75
           D C S+ C  +  C    G     C+C PG+ G  CE  +   G   CQHG  CHQ    
Sbjct: 72  DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIY 131

Query: 76  -QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
             CIC +G+AG+FC+ D   C + SPCQNG  C  DG   Y C C+PG+ GR C+ +   
Sbjct: 132 PVCICPAGYAGRFCEIDHDECAS-SPCQNGAVCQ-DGIDGYSCFCVPGYQGRHCDLEVDE 189

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C  A  PC+N   C ++ G    +TC C   + G  CE+ +D+C  +PC NGATC D + 
Sbjct: 190 C--ASDPCKNEATCLNEIG---RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALG 244

Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCP-SGYGGKTCELVLPV 253
            + C C  GF G  C +N D+CAS+PC  G  C D  + + C C  SG+ G  CE ++P+
Sbjct: 245 AYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPL 304



 Score =  144 bits (364), Expect = 1e-34
 Identities = 90/276 (32%), Positives = 124/276 (44%), Gaps = 45/276 (16%)

Query: 8   LHLVCLLCILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG----SCRCDPGWEGLHCE-- 58
           ++ VC+ C  G  G+   +  D+C SS C   +G    DG    SC C PG++G HC+  
Sbjct: 130 IYPVCI-CPAGYAGRFCEIDHDECASSPCQ--NGAVCQDGIDGYSCFCVPGYQGRHCDLE 186

Query: 59  --RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGG 113
              C   P     TC      + CIC   ++G  C+ +   C +Q PC NG  C  D  G
Sbjct: 187 VDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQ-PCLNGATCQ-DALG 244

Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL-VGFVGARCE 172
            Y C C PGF G  CE     C  A  PC +GG C D +     ++C C   GF G  CE
Sbjct: 245 AYFCDCAPGFLGDHCELNTDEC--ASQPCLHGGLCVDGEN---RYSCNCTGSGFTGTHCE 299

Query: 173 VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD--- 229
             +  C  +PC N ATC D ++ ++C C  G+ G  C I+L++C S PCQ    C +   
Sbjct: 300 TLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSS 359

Query: 230 -----------------RVHDFDCLCPSGYGGKTCE 248
                                + C+C  G+ G  CE
Sbjct: 360 EKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE 395



 Score =  137 bits (346), Expect = 1e-32
 Identities = 63/165 (38%), Positives = 90/165 (54%), Gaps = 7/165 (4%)

Query: 86  KFCDKDEHICTTQSPCQNGGQCMYDGGGE-YHCVCLPGFHGRDCERKAGPCEQAGSPCRN 144
           K CD  +  C + +PCQ    C+   G   + C C PG+ G  CE   G C +  + C++
Sbjct: 65  KDCDNMKDPCFS-NPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGK--NSCQH 121

Query: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
           GG C  D  + +   C C  G+ G  CE++ D+C   PC NGA C DGI+ +SC C  G+
Sbjct: 122 GGICHQDPIYPV---CICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGY 178

Query: 205 AGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            GR C + +D+CAS PC+  A C + +  + C+CP  Y G  CEL
Sbjct: 179 QGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCEL 223



 Score =  128 bits (321), Expect = 1e-29
 Identities = 72/202 (35%), Positives = 91/202 (45%), Gaps = 21/202 (10%)

Query: 29   CSSHCDLAHGCCAPDGS---CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCI 78
            C+S+  L  G C    S   C C  GW G HCE     C   P C HG C      + C 
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCT 1201

Query: 79   CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC--- 135
            C  G+ G  C+ D   C +   C NG  C+    G Y C+C   F G+ C +   P    
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQ-CANGATCISHTNG-YSCLCFGNFTGKFCRQSRLPSTVC 1259

Query: 136  --EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
              E+    C NGG C +   F     C C  GF G  CE ++D+C   PC NG  C D +
Sbjct: 1260 GNEKTNLTCYNGGNCTE---FQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316

Query: 194  NRFSCLCPEGFAGRFCTINLDD 215
            N+F CLC   FAG  C ++L D
Sbjct: 1317 NKFQCLCDVAFAGERCEVDLAD 1338



 Score =  127 bits (320), Expect = 1e-29
 Identities = 76/239 (31%), Positives = 101/239 (42%), Gaps = 39/239 (16%)

Query: 46  CRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPWQCICH-SGWAGKFCDKDEHICTT 97
           C C PG+ G HCE     C   P    G C      + C C  SG+ G  C+    +C +
Sbjct: 248 CDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307

Query: 98  QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD------- 150
           + PC N   C  D    Y C C PG+ G  CE     C    +PC++ G+C +       
Sbjct: 308 K-PCHNNATCE-DSVDNYTCHCWPGYTGAQCEIDLNECNS--NPCQSNGECVELSSEKQY 363

Query: 151 ----------DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
                         A  + C C  GF G  CE +V++C   PC NG TC +    ++C C
Sbjct: 364 GRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423

Query: 201 P------EGFAGRFCTINLDDCASRPCQRGARC----RDRVHDFDCLCPSGYGGKTCEL 249
           P        + GR C+  L  C  + C     C    +D  H F CLCPSGY G  CE+
Sbjct: 424 PFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  117 bits (293), Expect = 2e-26
 Identities = 66/223 (29%), Positives = 99/223 (44%), Gaps = 19/223 (8%)

Query: 60   CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
            C   P    G C   +  + C C  GW+GK C+ +   C + +PC +G     D    YH
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFS-NPCIHGN--CSDRVAAYH 1199

Query: 117  CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE---- 172
            C C PG+ G +CE     C+     C NG  C         ++C C   F G  C     
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQS--HQCANGATCISHTN---GYSCLCFGNFTGKFCRQSRL 1254

Query: 173  ---VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
               V  ++     C NG  C +      C+C  GF G +C  ++D+CAS PC  G  C+D
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQD 1314

Query: 230  RVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVV 272
             ++ F CLC   + G+ CE+ L   D  + + T +G  +  ++
Sbjct: 1315 LLNKFQCLCDVAFAGERCEVDL-ADDLISDIFTTIGSVTVALL 1356



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 35/139 (25%), Positives = 50/139 (35%), Gaps = 46/139 (33%)

Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLD---------------------- 191
           F L+F+   L+    + C  N   CL   C N +TC D                      
Sbjct: 12  FYLSFSL--LIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDN 69

Query: 192 --------------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC-RDR 230
                               G   F C CP G++G  C   +  C    CQ G  C +D 
Sbjct: 70  MKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDP 129

Query: 231 VHDFDCLCPSGYGGKTCEL 249
           ++   C+CP+GY G+ CE+
Sbjct: 130 IYPV-CICPAGYAGRFCEI 147



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 22/75 (29%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 176 DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD 235
           + C   PC NG  C    + FSC CP   +G+ C   +  C   PC  GA+C+  +  F+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947

Query: 236 CLCPSGYGGKTCELV 250
           C+  + + G++ +++
Sbjct: 948 CIANAVFNGQSGQIL 962



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 17/39 (43%), Positives = 21/39 (53%)

Query: 211  INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            + L+ C S PC  G  C D    + C CP G+ GK CEL
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCEL 1176



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 4/76 (5%)

Query: 132 AGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLD 191
           AG      +PC NGG C        +F+C C     G  CE  V  C   PC +GA C  
Sbjct: 886 AGDNSCKSNPCHNGGVCHSRWD---DFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQP 941

Query: 192 GINRFSCLCPEGFAGR 207
            +  F C+    F G+
Sbjct: 942 VLQGFECIANAVFNGQ 957



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 20/90 (22%)

Query: 40  CAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPW---QCICHSGWAGKFCDKDEHICT 96
           CA D SC+ +P   G              G CH  W    C C +  +GK C++ +    
Sbjct: 885 CAGDNSCKSNPCHNG--------------GVCHSRWDDFSCSCPALTSGKACEEVQ--WC 928

Query: 97  TQSPCQNGGQCMYDGGGEYHCVCLPGFHGR 126
             SPC +G QC     G + C+    F+G+
Sbjct: 929 GFSPCPHGAQCQPVLQG-FECIANAVFNGQ 957



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 13/37 (35%), Positives = 17/37 (45%)

Query: 211 INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
           +  D C S+PCQ   RC +    + C C   Y G  C
Sbjct: 671 VRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707


>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
          Length = 618

 Score =  177 bits (450), Expect = 1e-44
 Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)

Query: 29  CSSHCDLAHGCCAPDGSCRCDPGWEGLHCE---------------------------RCV 61
           C + C   HG C   G CRC  GW G  C                             C 
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279

Query: 62  RMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
             P    G+C +    ++C C  G+ G  C+     C    PC NGG C+   D    Y 
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC-ADGPCFNGGLCVGGADPDSAYI 338

Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
           C C PGF G +CE++   C     PCRNGG C  D G AL   CRC  GF G RCE ++D
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCL-DLGHALR--CRCRAGFAGPRCEHDLD 393

Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
           DC  R CANG TC++G     C C  GF GR C    D CA+RPC  G RC        C
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453

Query: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
            C  GY G  CE   PV PD  + +        P  P   ++ PA G   A   AGA LL
Sbjct: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511

Query: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
            + V+     Q+      AG  EPS+ AL
Sbjct: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540


>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
          Length = 587

 Score =  177 bits (450), Expect = 1e-44
 Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)

Query: 29  CSSHCDLAHGCCAPDGSCRCDPGWEGLHCE---------------------------RCV 61
           C + C   HG C   G CRC  GW G  C                             C 
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279

Query: 62  RMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
             P    G+C +    ++C C  G+ G  C+     C    PC NGG C+   D    Y 
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC-ADGPCFNGGLCVGGADPDSAYI 338

Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
           C C PGF G +CE++   C     PCRNGG C  D G AL   CRC  GF G RCE ++D
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCL-DLGHALR--CRCRAGFAGPRCEHDLD 393

Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
           DC  R CANG TC++G     C C  GF GR C    D CA+RPC  G RC        C
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453

Query: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
            C  GY G  CE   PV PD  + +        P  P   ++ PA G   A   AGA LL
Sbjct: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511

Query: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
            + V+     Q+      AG  EPS+ AL
Sbjct: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540


>gi|112420992 crumbs homolog 2 [Homo sapiens]
          Length = 1285

 Score =  169 bits (427), Expect = 5e-42
 Identities = 102/299 (34%), Positives = 138/299 (46%), Gaps = 43/299 (14%)

Query: 15  CILGAPGQP--VRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMP 64
           C LG  G    +  D+C+S   L  G C  DG     C C PG+ G  C+     C   P
Sbjct: 134 CPLGYAGVTCEMEVDECASAPCLHGGSCL-DGVGSFRCVCAPGYGGTRCQLDLDECQSQP 192

Query: 65  GCQHGTCHQ---PWQCICH-SGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
               GTCH     ++C C  +G+ G  C+++   C + +PC++   C+ +G G + C+C 
Sbjct: 193 CAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECAS-APCEHNASCL-EGLGSFRCLCW 250

Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFAL------------------NFTCRC 162
           PG+ G  CE     C  A SPC++GG+C      AL                   F C C
Sbjct: 251 PGYSGELCEVDEDEC--ASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHC 308

Query: 163 LVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
             GF GA C V VD+C  RPC NG  C D  N F C CP+G+AG  C  ++D+C S PC 
Sbjct: 309 PPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCL 368

Query: 223 RGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHS 281
            G  C D V  + C CP  +GG+ C + L      T       P +A  +P      HS
Sbjct: 369 HGGTCSDTVAGYICRCPETWGGRDCSVQL------TGCQGHTCPLAATCIPIFESGVHS 421



 Score =  165 bits (417), Expect = 7e-41
 Identities = 130/403 (32%), Positives = 164/403 (40%), Gaps = 84/403 (20%)

Query: 27  DDCSSHCDLAHGCCAPD--GSCRCD---PGWEGLHCER----CVRMPGCQHG-TCHQ--- 73
           D+C S    AHG    D     RCD    G+EG HCER    C   P C+H  +C +   
Sbjct: 186 DECQSQ-PCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAP-CEHNASCLEGLG 243

Query: 74  PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM-------YDG-------------GG 113
            ++C+C  G++G+ C+ DE  C + SPCQ+GG+C+       Y G               
Sbjct: 244 SFRCLCWPGYSGELCEVDEDECAS-SPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAA 302

Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
            + C C PGF G DC  +   C  A  PC NGG CQD       F C C  G+ G  CE 
Sbjct: 303 GFLCHCPPGFEGADCGVEVDEC--ASRPCLNGGHCQD---LPNGFQCHCPDGYAGPTCEE 357

Query: 174 NVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC----RD 229
           +VD+CL  PC +G TC D +  + C CPE + GR C++ L  C    C   A C      
Sbjct: 358 DVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFES 417

Query: 230 RVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGP--------APHS 281
            VH + C CP G  G  C          TT     G      VPA GP            
Sbjct: 418 GVHSYVCHCPPGTHGPFC-------GQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLP 470

Query: 282 AGAGLLRISVKE------VVRRQEAGLGEPSLVALVV-----------FGALTAALVLAT 324
           AG    R   KE      V    +A L   S   LV+           +  +   L LAT
Sbjct: 471 AGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLAT 530

Query: 325 VLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQVSMLPAGL 367
             L LR W  G CP   C        P         + LPAG+
Sbjct: 531 --LELRLWHEG-CPARLCVAS----GPVALASTASATPLPAGI 566



 Score =  157 bits (398), Expect = 1e-38
 Identities = 88/248 (35%), Positives = 116/248 (46%), Gaps = 45/248 (18%)

Query: 37  HGC-CAPDGS------CRCDPGWEGLHCE----RCVRMPGCQHG-TCH---QPWQCICHS 81
           HG  C P G       C C PG++G  CE     C   P C HG TC      ++C C  
Sbjct: 78  HGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRP-CHHGATCRNLADRYECHCPL 136

Query: 82  GWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP 141
           G+AG  C+ +   C + +PC +GG C+ DG G + CVC PG+ G  C+     C+    P
Sbjct: 137 GYAGVTCEMEVDECAS-APCLHGGSCL-DGVGSFRCVCAPGYGGTRCQLDLDECQ--SQP 192

Query: 142 CRNGGQCQDDQGFALNFTCRCL-VGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
           C +GG C D       F C C   G+ G  CE  V +C   PC + A+CL+G+  F CLC
Sbjct: 193 CAHGGTCHD---LVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLC 249

Query: 201 PEGFAGRFCTINLDDCASRPCQRGARCRDR---------------------VHDFDCLCP 239
             G++G  C ++ D+CAS PCQ G RC  R                        F C CP
Sbjct: 250 WPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCP 309

Query: 240 SGYGGKTC 247
            G+ G  C
Sbjct: 310 PGFEGADC 317



 Score =  138 bits (347), Expect = 9e-33
 Identities = 63/157 (40%), Positives = 86/157 (54%), Gaps = 9/157 (5%)

Query: 95  CTTQSPCQNGGQCMYDGGGE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQ 152
           C TQ PC +G  C+  G     + C C+PGF G  CE     C  A  PC +G  C++  
Sbjct: 71  CATQ-PCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDEC--ASRPCHHGATCRN-- 125

Query: 153 GFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN 212
             A  + C C +G+ G  CE+ VD+C   PC +G +CLDG+  F C+C  G+ G  C ++
Sbjct: 126 -LADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLD 184

Query: 213 LDDCASRPCQRGARCRDRVHDFDCLCP-SGYGGKTCE 248
           LD+C S+PC  G  C D V+ F C C  +GY G  CE
Sbjct: 185 LDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 221



 Score =  127 bits (320), Expect = 1e-29
 Identities = 61/155 (39%), Positives = 78/155 (50%), Gaps = 18/155 (11%)

Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG---SPCRNGGQCQDDQGFAL 156
           PC  G +C     G Y C               GP E  G    PC +G  C        
Sbjct: 46  PCAPGTECQATESGGYTC---------------GPMEPRGCATQPCHHGALCVPQGPDPT 90

Query: 157 NFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDC 216
            F C C+ GF G RCE+++D+C  RPC +GATC +  +R+ C CP G+AG  C + +D+C
Sbjct: 91  GFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150

Query: 217 ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
           AS PC  G  C D V  F C+C  GYGG  C+L L
Sbjct: 151 ASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDL 185



 Score =  100 bits (250), Expect = 2e-21
 Identities = 71/213 (33%), Positives = 91/213 (42%), Gaps = 19/213 (8%)

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            SPC + G C  D    + C C PG+ G  CE    PC  A  PC  G       G    F
Sbjct: 1063 SPCLHDGACR-DLFDAFACACGPGWEGPRCEAHVDPCHSA--PCARGRCHTHPDG---RF 1116

Query: 159  TCRCLVGFVGARCEVNVD--DCLMR-PCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
             CRC  GF G RC + V   +C +   C +G+ C  G    +C C EG AG+ C +    
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176

Query: 216  CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV--LPVPDPPTTVDTPLGPTSAVVVP 273
            C + PC  G  CR      +C+C + + G+ CE+   LP+P P         P   V VP
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLP--------FPLLEVAVP 1228

Query: 274  ATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPS 306
            A          GLL   +    RRQ  G   PS
Sbjct: 1229 AACACLLLLLLGLLSGILAARKRRQSEGTYSPS 1261



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 57/173 (32%), Positives = 69/173 (39%), Gaps = 26/173 (15%)

Query: 20   PGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CVRMPGC 66
            PG P     C      A   C  DG+CR         C PGWEG  CE     C   P C
Sbjct: 1045 PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP-C 1103

Query: 67   QHGTCHQ----PWQCICHSGWAGKFC--DKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
              G CH      ++C C  G+ G  C        C+    C +G  C   G    +C CL
Sbjct: 1104 ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPC-EGGSPAANCSCL 1162

Query: 121  PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
             G  G+ C+    PCE   +PC NGG C+   G +    C C   F G  CEV
Sbjct: 1163 EGLAGQRCQVPTLPCE--ANPCLNGGTCRAAGGVS---ECICNARFSGQFCEV 1210



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 30/76 (39%), Positives = 39/76 (51%), Gaps = 2/76 (2%)

Query: 178  CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD-FDC 236
            C   PC +   C D  + F+C C  G+ G  C  ++D C S PC RG RC       F+C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118

Query: 237  LCPSGYGGKTCELVLP 252
             CP G+GG  C L +P
Sbjct: 1119 RCPPGFGGPRCRLPVP 1134



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 47/160 (29%), Positives = 59/160 (36%), Gaps = 14/160 (8%)

Query: 24  VRADDCSSHCDLAHGCCA--PDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP-- 74
           V  D+C+S   L  G C   P+G  C C  G+ G  CE     C+  P    GTC     
Sbjct: 319 VEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVA 378

Query: 75  -WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM---YDGGGEYHCVCLPGFHGRDCER 130
            + C C   W G+ C      C   + C     C+     G   Y C C PG HG  C +
Sbjct: 379 GYICRCPETWGGRDCSVQLTGCQGHT-CPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQ 437

Query: 131 KAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
                  AGSP +         G AL F      G +  R
Sbjct: 438 NTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATR 477



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 33/109 (30%), Positives = 43/109 (39%), Gaps = 17/109 (15%)

Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
           P + +  P   GG+       + N T  C          V+ D C   PC NG TCL   
Sbjct: 783 PLDNSSQPSELGGRQ------SWNLTAGC----------VSEDMCSPDPCFNGGTCLVTW 826

Query: 194 NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
           N F C CP  F G  C   L  C  +PC   A C +    F C+  + +
Sbjct: 827 NDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATF 874



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 17/47 (36%), Positives = 23/47 (48%)

Query: 211 INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPP 257
           ++ D C+  PC  G  C    +DF C CP+ + G TC   L  P  P
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQP 852



 Score = 35.4 bits (80), Expect = 0.087
 Identities = 41/152 (26%), Positives = 51/152 (33%), Gaps = 32/152 (21%)

Query: 166 FVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
           F G   +V VD  L+ P   G   L G  R                  + C   PC  G 
Sbjct: 576 FAGCLQDVRVDGHLLLPEDLGENVLLGCER-----------------REQCRPLPCVHGG 618

Query: 226 RCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAG 285
            C D    F C C   + G TC   +P      T      P+SA  +    P P+   + 
Sbjct: 619 SCVDLWTHFRCDCARPHRGPTCADEIPA----ATFGLGGAPSSASFLLQELPGPNLTVSF 674

Query: 286 LLRISVKEVVRRQEAGL----GEPSLVALVVF 313
           LLR        R+ AGL       S   L VF
Sbjct: 675 LLR-------TRESAGLLLQFANDSAAGLTVF 699



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 5/59 (8%)

Query: 92  EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD 150
           E +C+   PC NGG C+     ++HC C   F G  C ++   C   G PC     C++
Sbjct: 808 EDMCSPD-PCFNGGTCLVTWN-DFHCTCPANFTGPTCAQQLW-C--PGQPCLPPATCEE 861


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  164 bits (415), Expect = 1e-40
 Identities = 88/223 (39%), Positives = 114/223 (51%), Gaps = 21/223 (9%)

Query: 46  CRCDPGWEGLHC----ERCVRMPG----CQHG-TCHQP---WQCICHSGWAGKFCDKDEH 93
           C C PG+ G  C    + C+        C+HG +C      + C+C  G+ G  C+ D +
Sbjct: 418 CLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHN 477

Query: 94  ICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG 153
            C +Q PC  G  C+ D    +HC+C PG  G+ CE +   C  A +PC N   C D   
Sbjct: 478 ECLSQ-PCHPGSTCL-DLLATFHCLCPPGLEGQLCEVETNEC--ASAPCLNHADCHD--- 530

Query: 154 FALN-FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN 212
             LN F C CL GF G RCE ++D+C   PCANG  C D    F C C  GF G  C   
Sbjct: 531 -LLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTE 589

Query: 213 LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPD 255
           +D+C S PC  GA C D    F CLCPSG+ G+ CE+ L  P+
Sbjct: 590 VDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN 632



 Score =  159 bits (403), Expect = 3e-39
 Identities = 84/239 (35%), Positives = 117/239 (48%), Gaps = 22/239 (9%)

Query: 27  DDCSS----HCDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMPGCQHGTCHQ--- 73
           D+C +    HC     C    GS  C C  GW G  CE     C+        TC     
Sbjct: 316 DECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVG 375

Query: 74  PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKA 132
            + C+C  G  G  C  ++ +C +Q PC    QC  +   G   C+C PG+ G  C +  
Sbjct: 376 SFSCLCPPGRTGLLCHLED-MCLSQ-PCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDL 433

Query: 133 GPC---EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
             C   +Q  SPC +GG C +  G   +F C C  G+ G+RCE + ++CL +PC  G+TC
Sbjct: 434 DECLMAQQGPSPCEHGGSCLNTPG---SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTC 490

Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
           LD +  F CLCP G  G+ C +  ++CAS PC   A C D ++ F C+C  G+ G  CE
Sbjct: 491 LDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE 549



 Score =  157 bits (397), Expect = 2e-38
 Identities = 96/254 (37%), Positives = 122/254 (48%), Gaps = 25/254 (9%)

Query: 15  CILGAPGQPVRADD-CSSHCDLAHGCCA---PDGSCRCDPGWEGLHCER----CVRMPG- 65
           C+ G  G+  +  D CS++  +  G C    P   C C PG+EG  CER    C + PG 
Sbjct: 145 CMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGP 204

Query: 66  CQHGT-CHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC--MYDGGGEYH-CV 118
           C  GT CH     +QC+C  G  G  C+     C  +  C NGG C  M +    +H C+
Sbjct: 205 CPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG-CSNGGTCQLMPEKDSTFHLCL 263

Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
           C PGF G DCE     C      C+NGG CQD       +TC C   + G  C  +VD+C
Sbjct: 264 CPPGFIGPDCEVNPDNC--VSHQCQNGGTCQDGLD---TYTCLCPETWTGWDCSEDVDEC 318

Query: 179 LMRP---CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD 235
             +    C NG TC +    F C+C  G+ G  C  NLDDC +  C  G+ C DRV  F 
Sbjct: 319 ETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFS 378

Query: 236 CLCPSGYGGKTCEL 249
           CLCP G  G  C L
Sbjct: 379 CLCPPGRTGLLCHL 392



 Score =  144 bits (363), Expect = 1e-34
 Identities = 80/240 (33%), Positives = 110/240 (45%), Gaps = 28/240 (11%)

Query: 45   SCRCDPGWEGLHCERCVRMPGCQHGTCH---------QPWQCICHSGWAGKFCDKDEHIC 95
            SC C  G++G  CE  +R P C    C          Q  +C+C +G+ G  C     +C
Sbjct: 790  SCLCAMGFQGPRCEGKLR-PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLC 848

Query: 96   TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG--------SPCRNGGQ 147
              Q PC     C+  G   +HC+CL G+ G  C      C++A         S C NGG 
Sbjct: 849  A-QKPCPRNSHCLQTGPS-FHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906

Query: 148  CQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGR 207
            C D      ++ C C  GF G+ C+ +V+ C  RPC NGATC+   + + C C  G+ G+
Sbjct: 907  CVDS---GPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQ 963

Query: 208  FCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPT 267
             C+  LD C S+PC     C  +   F C CP G+ G  CE      D    +D P  PT
Sbjct: 964  NCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCE-----GDVDECLDQPCHPT 1018



 Score =  138 bits (348), Expect = 7e-33
 Identities = 89/285 (31%), Positives = 118/285 (41%), Gaps = 39/285 (13%)

Query: 14   LCILGAPGQ----PVRADDCSSHCDLAHGCC-APDGS-CRCDPGWEGLHCER----CVRM 63
            LC +G  G      +R     S C     C  +P G  C C  G+ G  C+     C + 
Sbjct: 792  LCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK 851

Query: 64   PGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICT---------TQSPCQNGGQCMYDG 111
            P  ++  C Q    + C+C  GW G  C+     C            S C NGG C+ D 
Sbjct: 852  PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCV-DS 910

Query: 112  GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
            G  Y C C PGF G  C+    PCE    PC+NG  C         + C+C  G+ G  C
Sbjct: 911  GPSYFCHCPPGFQGSLCQDHVNPCESR--PCQNGATCMAQPS---GYLCQCAPGYDGQNC 965

Query: 172  EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRG--ARCRD 229
               +D C  +PC N  TC      F C CP GF G  C  ++D+C  +PC     A C  
Sbjct: 966  SKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHS 1025

Query: 230  RVHDFDCLCPSGYGGKTCELVL-PVPDPP--------TTVDTPLG 265
              + F C C  G+ G+ CE+ + P    P         T  +PLG
Sbjct: 1026 LANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLG 1070



 Score =  137 bits (344), Expect = 2e-32
 Identities = 87/310 (28%), Positives = 115/310 (37%), Gaps = 81/310 (26%)

Query: 14  LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCE----RC 60
           LC  G  G    AD    H +     C P  +C          C PG EG  CE     C
Sbjct: 462 LCPPGYTGSRCEAD----HNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC 517

Query: 61  VRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHC 117
              P   H  CH     +QCIC  G++G  C++D   C + SPC NGGQC  D  G +HC
Sbjct: 518 ASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRS-SPCANGGQCQ-DQPGAFHC 575

Query: 118 VCLPGFHGRDCERKAGPC------------------------------------------ 135
            CLPGF G  C+ +   C                                          
Sbjct: 576 KCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQ 635

Query: 136 ---------EQAGSPCRNGG--------QCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
                    ++A   C +G          C    G     +C C VG+ G  CE  +  C
Sbjct: 636 PKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGC 695

Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
           +  PCA+G TC    + ++C CP G+ G  C+  +  C S PC  G  C      + C C
Sbjct: 696 ISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTC 755

Query: 239 PSGYGGKTCE 248
           P  + G  C+
Sbjct: 756 PPSHTGPQCQ 765



 Score =  125 bits (313), Expect = 8e-29
 Identities = 87/306 (28%), Positives = 121/306 (39%), Gaps = 48/306 (15%)

Query: 14  LCILGAPGQPVRAD--DC-SSHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMP 64
           +C+ G  G     D  +C SS C     C    G+  C+C PG+EG  C+     C+  P
Sbjct: 538 ICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDP 597

Query: 65  GCQHGTCHQ---PWQCICHSGWAGKFCD---------KDEHICTTQ-------------- 98
                +C      + C+C SG+ G+ C+         + + IC  Q              
Sbjct: 598 CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG 657

Query: 99  -SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
            +P ++   C +       CVC  G+ G +CE + G C  A  PC +GG C         
Sbjct: 658 CAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISA--PCAHGGTCYPQPS---G 712

Query: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCA 217
           + C C  G+ G  C   +  C   PC NG +C      + C CP    G  C  + D C 
Sbjct: 713 YNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCV 772

Query: 218 SRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-------PVPDPPTTVDTPLGPTSAV 270
           S PC  G  C +R   F CLC  G+ G  CE  L       P  +  T  D+P GP    
Sbjct: 773 SAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLC 832

Query: 271 VVPATG 276
               TG
Sbjct: 833 PTGYTG 838



 Score =  122 bits (307), Expect = 4e-28
 Identities = 86/311 (27%), Positives = 113/311 (36%), Gaps = 68/311 (21%)

Query: 2   PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCA---PDGSCRCDPGWEGLHCE 58
           PS    L L+ LLC+     + +        C     C +     G+C+C PG+ G  C+
Sbjct: 4   PSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQ 63

Query: 59  ---RCVRMPGCQHGTCHQP------------------WQCICHSGWAGKFCDKDEHICTT 97
               C     CQ+G   Q                   + C C  G+ G+ C         
Sbjct: 64  FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCP 123

Query: 98  QSPCQNGGQCMYDGGGEYHCVCLPGFHGRD------------------------------ 127
            S C   G+C     G   C C+PG+ G                                
Sbjct: 124 PSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCP 183

Query: 128 -------CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
                  CER    C Q   PC  G  C +  G   +F C C VG  G RCE+    C  
Sbjct: 184 PGFEGHACERDVNECFQDPGPCPKGTSCHNTLG---SFQCLCPVGQEGPRCELRAGPCPP 240

Query: 181 RPCANGATCLDGINRFS----CLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
           R C+NG TC     + S    CLCP GF G  C +N D+C S  CQ G  C+D +  + C
Sbjct: 241 RGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC 300

Query: 237 LCPSGYGGKTC 247
           LCP  + G  C
Sbjct: 301 LCPETWTGWDC 311



 Score =  107 bits (266), Expect = 2e-23
 Identities = 71/238 (29%), Positives = 90/238 (37%), Gaps = 21/238 (8%)

Query: 30   SSHCDLAHGCCA-PDGS-CRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICH 80
            S  C     C A P G  C+C PG++G +C +    C   P   HGTC      + C C 
Sbjct: 936  SRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACP 995

Query: 81   SGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
             G+ G  C+ D   C  Q     G    +     ++C CLPG  G+ CE +  PC     
Sbjct: 996  PGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHS--Q 1053

Query: 141  PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF---S 197
            PC +GG C+   G  L F C C  GF G  C      C    C +G  CL          
Sbjct: 1054 PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPR 1113

Query: 198  CLCPEGFAGRFCTI--NLDDCA-SRPCQRGARCRDRV----HDFDCLCPSGYGGKTCE 248
            C C  G+ G  C        C    PC     C +        F C CP    G  C+
Sbjct: 1114 CACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 17/93 (18%)

Query: 182 PCANGATCLD-GINRFSCLCPEGFAGRFCTINLDDCASRP-CQRGARCRDRVH------- 232
           PCANG TCL   + + +C C  GF G  C    D C +   CQ G  C+  +        
Sbjct: 34  PCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQNAQLCQNGGSCQALLPAPLGLPS 92

Query: 233 -------DFDCLCPSGYGGKTCELVLPVPDPPT 258
                   F C C  G+ G+ C+  L  P PP+
Sbjct: 93  SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPS 125


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  152 bits (383), Expect = 6e-37
 Identities = 83/243 (34%), Positives = 123/243 (50%), Gaps = 36/243 (14%)

Query: 40   CAPDGSCRCDP----------GWEGLHCE----RCVRMPGCQHG-TCH------QPWQCI 78
            C  DG+C  DP          G++G  C+     C+  P C+HG TCH        + CI
Sbjct: 927  CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCI 985

Query: 79   CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
            C  G+ G+ C+ +   C   + C+N   C+ DG   Y C+C P + G  CE K   C Q 
Sbjct: 986  CADGFEGENCEVNVDDCE-DNDCENNSTCV-DGINNYTCLCPPEYTGELCEEKLDFCAQD 1043

Query: 139  GSPCRNGGQC-QDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFS 197
             +PC++  +C    +GF     C C  G+VG  C+++ DDC    C NGA C D +N ++
Sbjct: 1044 LNPCQHDSKCILTPKGFK----CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099

Query: 198  CLCPEGFAGRFCTIN-------LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
            C+CPEG++G FC  +          C +  CQ GA+C  R+++  C C  GY G+ CE +
Sbjct: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159

Query: 251  LPV 253
            + V
Sbjct: 1160 VSV 1162



 Score =  143 bits (360), Expect = 3e-34
 Identities = 71/201 (35%), Positives = 91/201 (45%), Gaps = 42/201 (20%)

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            +PC+N G C  D    Y C C  GF G+DC+     C    +PC++GG C   +G    F
Sbjct: 925  NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC--ISNPCKHGGTCHLKEGEEDGF 982

Query: 159  TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE---------------- 202
             C C  GF G  CEVNVDDC    C N +TC+DGIN ++CLCP                 
Sbjct: 983  WCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQ 1042

Query: 203  ------------------------GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
                                    G+ G  C I+ DDC    C+ GA C D V+ + C+C
Sbjct: 1043 DLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCIC 1102

Query: 239  PSGYGGKTCELVLPVPDPPTT 259
            P GY G  CE   P+  P T+
Sbjct: 1103 PEGYSGLFCEFSPPMVLPRTS 1123



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 49/158 (31%), Positives = 67/158 (42%), Gaps = 30/158 (18%)

Query: 36   AHGCCAPDG----SCRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGW 83
            AHG C P      +C C  GW G  C++    P     C HGTC       + C C  G 
Sbjct: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGH 1401

Query: 84   AGKFCDKDEHICTTQSPCQ----NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
             G  CD++E +    +PCQ      G+C   G G+ +C C  G+ G  C+R+   C   G
Sbjct: 1402 GGVLCDEEEDLF---NPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR--G 1455

Query: 140  SPCRNGGQCQDDQGFALNFTCR------CLVGFVGARC 171
               R+    Q  QG+A   T +      C  G  G +C
Sbjct: 1456 ERIRD--YYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 12/121 (9%)

Query: 135  CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD-CLMRPCANGATCLDGI 193
            CE         G CQ        FTC C  G++G  C+   +D CL   C +G TCL  I
Sbjct: 1333 CEPCHKKVCAHGTCQPSS--QAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLP-I 1388

Query: 194  NRFS--CLCPEGFAGRFCTINLD---DCASRPCQRGARCR-DRVHDFDCLCPSGYGGKTC 247
            N FS  C C EG  G  C    D    C +  C+ G +CR   +    C C SGY G +C
Sbjct: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSC 1447

Query: 248  E 248
            +
Sbjct: 1448 D 1448



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 52/204 (25%), Positives = 73/204 (35%), Gaps = 42/204 (20%)

Query: 57   CERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNG----GQCM 108
            CE C +   C HGTC    Q    C C  GW G  CD+      T  PC       G C+
Sbjct: 1333 CEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQ-----RTNDPCLGNKCVHGTCL 1386

Query: 109  YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR----NGGQCQDDQGFALNFTCRCLV 164
                  Y C CL G  G  C+ +    E   +PC+      G+C+   G    + C C  
Sbjct: 1387 PINAFSYSCKCLEGHGGVLCDEE----EDLFNPCQAIKCKHGKCR-LSGLGQPY-CECSS 1440

Query: 165  GFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLD------DCAS 218
            G+ G  C+  +          G    D   +      +G+A    T  +        CA 
Sbjct: 1441 GYTGDSCDREIS-------CRGERIRDYYQK-----QQGYAACQTTKKVSRLECRGGCAG 1488

Query: 219  RPCQRGARCRDRVHDFDCLCPSGY 242
              C    R + R + F+C   S +
Sbjct: 1489 GQCCGPLRSKRRKYSFECTDGSSF 1512


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  150 bits (379), Expect = 2e-36
 Identities = 75/201 (37%), Positives = 90/201 (44%), Gaps = 44/201 (21%)

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            SPCQN G C  D    Y C C  G+ GRDCE     C  +  PC NGG C   +G    F
Sbjct: 932  SPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC--SSGPCENGGTCHAQEGEDAPF 989

Query: 159  TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCP----------------- 201
            TC C  GF G  C VN DDC+   CANG  C+DG+  ++C CP                 
Sbjct: 990  TCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSP 1049

Query: 202  -----------------------EGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
                                    G+AG  C+ N DDC    CQ GA+C D V+ + CLC
Sbjct: 1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLC 1109

Query: 239  PSGYGGKTCELV--LPVPDPP 257
              GY G+ CE+   LP P  P
Sbjct: 1110 AEGYSGQLCEIPPHLPAPKSP 1130



 Score =  148 bits (373), Expect = 9e-36
 Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 27/258 (10%)

Query: 18   GAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMPGCQ 67
            G P   V+A  D C S      G C  D      C C  G++G  CE     C   P   
Sbjct: 916  GPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCEN 975

Query: 68   HGTCHQ------PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
             GTCH       P+ C C +G+ G  C  +   C   + C NGG C+ DG G Y C C  
Sbjct: 976  GGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCV-DGVGNYTCQCPL 1033

Query: 122  GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMR 181
             + G+ CE+    C    +PC++  QC    G      C C+ G+ G  C  N DDC   
Sbjct: 1034 QYEGKACEQLVDLCSPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDH 1090

Query: 182  PCANGATCLDGINRFSCLCPEGFAGRFCTIN------LDDCASRPCQRGARCRDRVHDFD 235
             C NGA C+D +N +SCLC EG++G+ C I          C    CQ GA C D+ +   
Sbjct: 1091 RCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV 1150

Query: 236  CLCPSGYGGKTCELVLPV 253
            C C  G+GG  CE +L V
Sbjct: 1151 CQCLPGFGGPECEKLLSV 1168



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 48/143 (33%), Positives = 67/143 (46%), Gaps = 24/143 (16%)

Query: 37   HGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGWA 84
            HG C P+ +    C C+ GW GLHC++    P     C HG C       + C C  G++
Sbjct: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYS 1408

Query: 85   GKFCDKDEHICTTQSPCQN----GGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
            G  C++   +     PC+      G C   G    HCVC PGF G  CE+++   E  G 
Sbjct: 1409 GALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES---ECRGD 1462

Query: 141  PCRNGGQCQDDQGFALNFTCRCL 163
            P R+  Q Q  +G+A+  T R L
Sbjct: 1463 PVRDFHQVQ--RGYAICQTTRPL 1483



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 28/126 (22%)

Query: 117  CVCLPGFHGRDCERKA-GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
            C C  G+ G  C++ A GPC   G  C +G QC      AL+++C+C  G+ GA C  N 
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCH--GHKCVHG-QCVPLD--ALSYSCQCQDGYSGALC--NQ 1414

Query: 176  DDCLMRPCANGATCLDGINRFS------CLCPEGFAGRFCTINLDDCASRPCQRGARCR- 228
               L  PC  G  CL G  + S      C+C  GF+G              C++ + CR 
Sbjct: 1415 AGALAEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGEL------------CEQESECRG 1461

Query: 229  DRVHDF 234
            D V DF
Sbjct: 1462 DPVRDF 1467



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 12/97 (12%)

Query: 160  CRCLVGFVGARCEVNVDD-CLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCA 217
            C C  G+VG  C+   D  C    C +G    LD ++ +SC C +G++G  C  N     
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS-YSCQCQDGYSGALC--NQAGAL 1418

Query: 218  SRPCQRGARC------RDRVHDFDCLCPSGYGGKTCE 248
            + PC RG +C              C+C  G+ G+ CE
Sbjct: 1419 AEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 16/60 (26%), Positives = 20/60 (33%), Gaps = 1/60 (1%)

Query: 198  CLCPEGFAGRFCTINLDD-CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
            C C  G+ G  C    D  C    C  G         + C C  GY G  C     + +P
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  149 bits (377), Expect = 3e-36
 Identities = 77/205 (37%), Positives = 104/205 (50%), Gaps = 19/205 (9%)

Query: 60  CVRMPGCQHG--------TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG 111
           C+ +  C +G        T +  + C C SG+ G+ C  D + C +Q PCQNGG C + G
Sbjct: 272 CLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQ-PCQNGGTCTH-G 329

Query: 112 GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
              + C C  GF G  CE    PC+     C++GGQCQ + G A+   C C  G+ GA C
Sbjct: 330 INSFRCQCPAGFGGPTCETAQSPCDT--KECQHGGQCQVENGSAV---CVCQAGYTGAAC 384

Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN----LDDCASRPCQRGARC 227
           E++VDDC   PC NG +C+D +  ++CLC E F G  C        D C S PC  G  C
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444

Query: 228 RDRVHDFDCLCPSGYGGKTCELVLP 252
            D    + C CP G+ G  C   +P
Sbjct: 445 VDADQGYVCECPEGFMGLDCRERVP 469



 Score =  139 bits (350), Expect = 4e-33
 Identities = 82/219 (37%), Positives = 101/219 (46%), Gaps = 23/219 (10%)

Query: 42  PDGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHI 94
           P  +C C  G+ G  C      C   P    GTC      ++C C +G+ G  C+  +  
Sbjct: 293 PSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSP 352

Query: 95  CTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF 154
           C T+  CQ+GGQC  + G    CVC  G+ G  CE     C     PC NGG C D  G 
Sbjct: 353 CDTKE-CQHGGQCQVENGSAV-CVCQAGYTGAACEMDVDDCSP--DPCLNGGSCVDLVG- 407

Query: 155 ALNFTCRCLVGFVGARCEVN----VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
             N+TC C   F G RCE       D CL  PC NG TC+D    + C CPEGF G  C 
Sbjct: 408 --NYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR 465

Query: 211 INL-DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
             + DDC    C+ G RC    +   C CP G+ G  CE
Sbjct: 466 ERVPDDC---ECRNGGRCLG-ANTTLCQCPLGFFGLLCE 500



 Score =  129 bits (325), Expect = 3e-30
 Identities = 92/276 (33%), Positives = 119/276 (43%), Gaps = 37/276 (13%)

Query: 15  CILGAPGQPVRAD-DCSSHCDLAHGCCAPDGS-------CRCDPGWEGLHCERCVRMPGC 66
           C  G  G+  +A+ DC    ++ H     +G+         CD G+  L     +R+  C
Sbjct: 683 CQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYS-LSAPSRIRV--C 739

Query: 67  Q-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
           Q HG   +P QC+          + DE  C +Q PC +GG C  D    Y C+C  G+ G
Sbjct: 740 QPHGVWSEPPQCL----------EIDE--CRSQ-PCLHGGSCQ-DRVAGYLCLCSTGYEG 785

Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
             CE +   C     PCRNGG C++  G    + CRC  GFVG  CE  VD C   PC +
Sbjct: 786 AHCELERDECR--AHPCRNGGSCRNLPGA---YVCRCPAGFVGVHCETEVDACDSSPCQH 840

Query: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
           G  C  G   + C+CPE F G  C    D C S PC     C        C C  GY G+
Sbjct: 841 GGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGE 900

Query: 246 TCELVLPVPDPPTTVDTPLGPTSAVVV---PATGPA 278
            C   L    PPT +       S V +   P  GPA
Sbjct: 901 DCAKEL---FPPTALKMERVEESGVSISWNPPNGPA 933



 Score =  129 bits (324), Expect = 4e-30
 Identities = 84/290 (28%), Positives = 111/290 (38%), Gaps = 74/290 (25%)

Query: 29  CSSHCDLAHGCCAPDGS---CRCDPGWEGLHCERCVRMPGCQHGTCHQ---------PWQ 76
           CSS      G C   G    C C   + G HCE   +   C  G CH           ++
Sbjct: 584 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE-IGKPDSCASGPCHNGGTCFHYIGKYK 642

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA--GP 134
           C C  G++G+ C+     C  +SPC NGG C  D   ++ C C  G+ GR C+ +   GP
Sbjct: 643 CDCPPGFSGRHCEIAPSPCF-RSPCVNGGTCE-DRDTDFFCHCQAGYMGRRCQAEVDCGP 700

Query: 135 --------------------------------------CEQAG----------------S 140
                                                 C+  G                 
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQ 760

Query: 141 PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
           PC +GG CQD       + C C  G+ GA CE+  D+C   PC NG +C +    + C C
Sbjct: 761 PCLHGGSCQDR---VAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRC 817

Query: 201 PEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
           P GF G  C   +D C S PCQ G RC      + C+CP  + G  CE V
Sbjct: 818 PAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETV 867



 Score =  123 bits (308), Expect = 3e-28
 Identities = 89/271 (32%), Positives = 116/271 (42%), Gaps = 36/271 (13%)

Query: 3   SGCRCLHLVC-LLCILGAPGQPVRA--------DDC-SSHCDLAHGCCAPDGS--CRCDP 50
           +G  C+ LV    C+   P + +R         D C S+ C     C   D    C C  
Sbjct: 398 NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPE 457

Query: 51  GWEGLHCERCVRMPG---CQHG-TC--HQPWQCICHSGWAGKFCDKDEHI--CTTQSPCQ 102
           G+ GL C    R+P    C++G  C       C C  G+ G  C+ +     C   + C 
Sbjct: 458 GFMGLDCRE--RVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCP 515

Query: 103 NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ--DDQGFALNFTC 160
           +GG CM + GG Y CVC    +         PC+    PC NGG C   DD     ++TC
Sbjct: 516 DGGYCM-EHGGSYLCVCHTDHNAS--HSLPSPCDS--DPCFNGGSCDAHDD-----SYTC 565

Query: 161 RCLVGFVGARCE-VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL-DDCAS 218
            C  GF G  CE      C   PC NG TC +    + C CP  F GR C I   D CAS
Sbjct: 566 ECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS 625

Query: 219 RPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            PC  G  C   +  + C CP G+ G+ CE+
Sbjct: 626 GPCHNGGTCFHYIGKYKCDCPPGFSGRHCEI 656



 Score =  114 bits (285), Expect = 1e-25
 Identities = 59/151 (39%), Positives = 78/151 (51%), Gaps = 12/151 (7%)

Query: 118 VCLPG---FHGRDCERKAGPCEQAGS------PCRNGGQCQDDQGFAL-NFTCRCLVGFV 167
           V +PG   F   D + + G C    S      PC NGG+C DD      ++TC CL GF 
Sbjct: 245 VGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFT 304

Query: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
           G RC ++V++C  +PC NG TC  GIN F C CP GF G  C      C ++ CQ G +C
Sbjct: 305 GRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQC 364

Query: 228 RDRVHDFDCLCPSGYGGKTCELVLP--VPDP 256
           +       C+C +GY G  CE+ +    PDP
Sbjct: 365 QVENGSAVCVCQAGYTGAACEMDVDDCSPDP 395



 Score =  114 bits (284), Expect = 2e-25
 Identities = 87/324 (26%), Positives = 120/324 (37%), Gaps = 88/324 (27%)

Query: 15  CILGAPGQPVRAD--DCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCERCVR---MPGC 66
           C+ G  G+    D  +C+S      G C    +   C+C  G+ G  CE          C
Sbjct: 299 CLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKEC 358

Query: 67  QHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
           QHG   Q       C+C +G+ G  C+ D   C+   PC NGG C+ D  G Y C+C   
Sbjct: 359 QHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPD-PCLNGGSCV-DLVGNYTCLCAEP 416

Query: 123 FHGRDCERKAGPCEQA--GSPCRNGGQCQD-DQGF------------------------- 154
           F G  CE    P   A   +PC NGG C D DQG+                         
Sbjct: 417 FKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRN 476

Query: 155 ------ALNFTCRCLVGFVGARCEVNV--------------------------------- 175
                 A    C+C +GF G  CE  +                                 
Sbjct: 477 GGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHN 536

Query: 176 ------DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD-CASRPCQRGARCR 228
                   C   PC NG +C    + ++C CP GF G+ C       C+S PC+ G  C+
Sbjct: 537 ASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCK 596

Query: 229 DRVHDFDCLCPSGYGGKTCELVLP 252
           +   ++ C CP  + G+ CE+  P
Sbjct: 597 EAGGEYHCSCPYRFTGRHCEIGKP 620



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 21/47 (44%), Positives = 25/47 (53%), Gaps = 1/47 (2%)

Query: 177  DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
            +C   PC NG TC+ G +  SC C  GF GR C +      SRPC R
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPCTR 1355



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 24/61 (39%), Positives = 31/61 (50%), Gaps = 10/61 (16%)

Query: 97   TQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE----RKAGPC-----EQAGSPCRNGGQ 147
            +++PCQNGG C+  G   + C C PGF GR CE    + + PC     E    P   GG 
Sbjct: 1312 SENPCQNGGTCV-PGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370

Query: 148  C 148
            C
Sbjct: 1371 C 1371



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 120  LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL 179
            LP    +D     G C +  +PC+NGG C      A   +C C  GF G RCE+     +
Sbjct: 1296 LPEHGSKDIGNVPGNCSE--NPCQNGGTCVPG---ADAHSCDCGPGFKGRRCELACIK-V 1349

Query: 180  MRPC 183
             RPC
Sbjct: 1350 SRPC 1353



 Score = 35.4 bits (80), Expect = 0.087
 Identities = 15/45 (33%), Positives = 19/45 (42%)

Query: 215  DCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTT 259
            +C+  PCQ G  C        C C  G+ G+ CEL       P T
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCT 1354



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 18/67 (26%), Positives = 28/67 (41%), Gaps = 18/67 (26%)

Query: 28   DCSSHCDLAHGCCAPDG---SCRCDPGWEGLHCE-RCVRM--------------PGCQHG 69
            +CS +     G C P     SC C PG++G  CE  C+++              P  + G
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369

Query: 70   TCHQPWQ 76
             CH  ++
Sbjct: 1370 VCHHVYK 1376


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  147 bits (371), Expect = 2e-35
 Identities = 73/216 (33%), Positives = 104/216 (48%), Gaps = 15/216 (6%)

Query: 46   CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ--CICHSGWAGKFCDKDEHICT 96
            C C  GW G +C      C   P    G CH+   P Q  C+C   + G+FC +  ++C 
Sbjct: 795  CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD 854

Query: 97   T-QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFA 155
               +PC+N   C+       HC+C   F G++CE     C      C++ G C+D     
Sbjct: 855  LLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS--CQDYGDCED---MV 909

Query: 156  LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
             NF C C  GF G+ CE+ +++C   PC N  TC+D  NRF C C   + G FC ++++ 
Sbjct: 910  NNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNK 969

Query: 216  CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
            C   PC     C  R   ++CLC  GY G  CE+ L
Sbjct: 970  CKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINL 1005



 Score =  146 bits (369), Expect = 3e-35
 Identities = 76/234 (32%), Positives = 116/234 (49%), Gaps = 25/234 (10%)

Query: 33   CDLAHGCCAPDGSCR----------CDPGWEGLHCERCVR---MPGCQ-HGTCHQP---W 75
            CDL H  C  + +C           C   +EG +CE  V+      CQ +G C      +
Sbjct: 853  CDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNF 912

Query: 76   QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
            +CIC  G++G  C+ + + C+++ PC+N G C+ D    + C C P +HG  CE     C
Sbjct: 913  RCICRPGFSGSLCEIEINECSSE-PCKNNGTCV-DLTNRFFCNCEPEYHGPFCELDVNKC 970

Query: 136  EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
            +   SPC +   C         + C C  G+ G  CE+N+D+CL  PC +   C+DGIN 
Sbjct: 971  KI--SPCLDEENCVYRTD---GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH 1025

Query: 196  FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            ++C C  GF G  C  N +DC S PC  G RC + ++++ C C +      C++
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEYPCSCDADGTSTQCKI 1078



 Score =  138 bits (348), Expect = 7e-33
 Identities = 77/217 (35%), Positives = 108/217 (49%), Gaps = 21/217 (9%)

Query: 45   SCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTT 97
            +C C PG+ G++CE     C+  P    G C      + C C SG+ G  C+ + + C +
Sbjct: 989  NCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLS 1048

Query: 98   QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
             +PC +G +C  +   EY C C        C+ K   C     PC N G CQ     A  
Sbjct: 1049 -NPCLHG-RCT-ELINEYPCSCDADGTSTQCKIKINDCTSI--PCMNEGFCQKS---AHG 1100

Query: 158  FTCRCLVGFVGARCEVNVDDCLMRP-----CANGATCLDGINR-FSCLCPEGFAGRFCTI 211
            FTC C  G+ GA CE ++D+C         C NG  C+DG    F C C  GF+G+FC I
Sbjct: 1101 FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEI 1160

Query: 212  NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            N+++C+S PC  GA C D ++ + C C  G+ G  CE
Sbjct: 1161 NINECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197



 Score =  129 bits (325), Expect = 3e-30
 Identities = 87/254 (34%), Positives = 113/254 (44%), Gaps = 26/254 (10%)

Query: 14   LCILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRM 63
            LC  G  G    +  D+C S   L  G C  DG    +C C  G+ G HCE     C+  
Sbjct: 991  LCAPGYTGINCEINLDECLSEPCLHDGVCI-DGINHYTCDCKSGFFGTHCETNANDCLSN 1049

Query: 64   PGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
            P C HG C +    + C C +      C    + CT+  PC N G C     G + C+C 
Sbjct: 1050 P-CLHGRCTELINEYPCSCDADGTSTQCKIKINDCTS-IPCMNEGFCQKSAHG-FTCICP 1106

Query: 121  PGFHGRDCERKAGPC---EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD 177
             G+ G  CE+    C   E     C NGG C D  G    F CRCL GF G  CE+N+++
Sbjct: 1107 RGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHT--FDCRCLPGFSGQFCEININE 1164

Query: 178  CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCL 237
            C   PC +GA C D IN + C C  G++G  C   L +C    C     C +      CL
Sbjct: 1165 CSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-ECIPNSCVH-ELCMENEPGSTCL 1222

Query: 238  CPSGYGGKTCELVL 251
            C  G+   TC + L
Sbjct: 1223 CTPGF--MTCSIGL 1234



 Score =  114 bits (284), Expect = 2e-25
 Identities = 79/278 (28%), Positives = 110/278 (39%), Gaps = 41/278 (14%)

Query: 3   SGCRCL--------HLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDP 50
           +GC CL          +C L   G        DD  + C   H     D      C C  
Sbjct: 537 NGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQ--HEAVCKDEINRPRCSCSL 594

Query: 51  GWEGLHCERCVRMPGCQ-------HGTCHQ-PWQCICHS--GWAGKFCDKDEHICTTQSP 100
            + G  C   V +  C        HG C      C C     +    C+ D   C + S 
Sbjct: 595 SYIGRLC--VVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSAS- 651

Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFAL---- 156
           C+NG    +  G  +   C+PGF G  CE     C  A  PC+NG  C D  G       
Sbjct: 652 CKNGTTSTHLRGYFFR-KCVPGFKGTQCEIDIDEC--ASHPCKNGATCIDQPGNYFCQCV 708

Query: 157 -------NFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
                   F+C C  G+VG RCE ++DDC++  C + +TC D    + C+C   + G FC
Sbjct: 709 PPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFC 768

Query: 210 TINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
               ++C   PC+  + C D    + C C SG+ G+ C
Sbjct: 769 EQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC 806



 Score =  112 bits (281), Expect = 4e-25
 Identities = 80/271 (29%), Positives = 115/271 (42%), Gaps = 42/271 (15%)

Query: 5   CRC-LHLVCLLCILGAPGQPVRADDC-SSHCDLAHGCC-APDGSCRCD--PGWEGLHCE- 58
           C C L  +  LC+       V  D C  +H    HG C A   +C C     +E   CE 
Sbjct: 590 CSCSLSYIGRLCV-------VNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEI 642

Query: 59  --RCVRMPGCQHGTCHQPWQCI----CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
                +   C++GT     +      C  G+ G  C+ D   C +  PC+NG  C+ D  
Sbjct: 643 DTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH-PCKNGATCI-DQP 700

Query: 113 GEYHCVCLP--------------GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
           G Y C C+P              G+ G  CE+    C    + C +   C+D     L++
Sbjct: 701 GNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCIL--NACEHNSTCKD---LHLSY 755

Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
            C CL  + G  CE   ++C M PC N +TC D    + C C  G+ G+ C+  +++C S
Sbjct: 756 QCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDS 815

Query: 219 RPCQRGARCRDRV--HDFDCLCPSGYGGKTC 247
            PC  G  C +      F CLCP  Y G+ C
Sbjct: 816 DPCMNGGLCHESTIPGQFVCLCPPLYTGQFC 846



 Score =  103 bits (256), Expect = 3e-22
 Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 30/204 (14%)

Query: 66  CQH-GTC----HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC- 119
           CQH   C    ++P +C C   + G+ C  +   C         G C+      ++C C 
Sbjct: 575 CQHEAVCKDEINRP-RCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCL---ALSHNCNCS 630

Query: 120 -LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
            L  +    CE     C+ A   C+NG      +G+   F  +C+ GF G +CE+++D+C
Sbjct: 631 GLQRYERNICEIDTEDCKSAS--CKNGTTSTHLRGY---FFRKCVPGFKGTQCEIDIDEC 685

Query: 179 LMRPCANGATCLDG--------------INRFSCLCPEGFAGRFCTINLDDCASRPCQRG 224
              PC NGATC+D               ++ FSCLC  G+ G  C  ++DDC    C+  
Sbjct: 686 ASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHN 745

Query: 225 ARCRDRVHDFDCLCPSGYGGKTCE 248
           + C+D    + C+C S + G  CE
Sbjct: 746 STCKDLHLSYQCVCLSDWEGNFCE 769



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)

Query: 22  QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71
           + + ++ CS H        +   SC C P + G +C+    C   P   +G+C       
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235

Query: 72  -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
             Q ++C+CH  + GK C +       H+C         G C       + C C   F G
Sbjct: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288

Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
             CE  A PC       R  G C +       +T  C  G      E +V +  + PC N
Sbjct: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343

Query: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
           G  C+   N   C+C   F    C      C S P +  A C+    D+ C C SG+  K
Sbjct: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403

Query: 246 TCE 248
            CE
Sbjct: 404 NCE 406



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 64/212 (30%), Positives = 87/212 (41%), Gaps = 42/212 (19%)

Query: 26   ADDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---W 75
            A+DC S+  L HG C     +  C CD       C+     C  +P    G C +    +
Sbjct: 1043 ANDCLSNPCL-HGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGF 1101

Query: 76   QCICHSGWAGKFCDKDEHICTTQSP----CQNGGQCMYDGGGEYHCVCLPGFHGRDCERK 131
             CIC  G+ G +C+K    C         C NGG C+   G  + C CLPGF G+ CE  
Sbjct: 1102 TCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEIN 1161

Query: 132  AGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD--------------- 176
               C  + SPC +G  C+D       + C+C  G+ G  CE  ++               
Sbjct: 1162 INEC--SSSPCLHGADCEDHIN---GYVCKCQPGWSGHHCENELECIPNSCVHELCMENE 1216

Query: 177  ---DCLMRP----CANGATCLDGINRFSCLCP 201
                CL  P    C+ G  C D I R +CL P
Sbjct: 1217 PGSTCLCTPGFMTCSIGLLCGDEIRRITCLTP 1248



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)

Query: 53  EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
           E L  E C     C      + + C C   ++GK+C + +    +  PC+N G C+    
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233

Query: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168
                 Y CVC P F G++C    G C+     C +G  C +    + +F C C   F G
Sbjct: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288

Query: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
             CEV+   C+         C +  + ++  CP+G + +    ++ + +  PCQ G  C 
Sbjct: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348

Query: 229 DRVHDFDCLCPSGYGGKTCELV 250
              +D  C+C   +    C+ +
Sbjct: 349 KISNDVMCICSPIFTDLLCKSI 370



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 30/90 (33%), Positives = 39/90 (43%), Gaps = 5/90 (5%)

Query: 172  EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDC-----ASRPCQRGAR 226
            + +   C +  C NG TC++      C C  G+ G FCT  +  C         C RGA 
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667

Query: 227  CRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
            C    H + C CP G  G  CE  L + DP
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQALSISDP 2697



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 74/347 (21%), Positives = 102/347 (29%), Gaps = 141/347 (40%)

Query: 40  CAPDGSCRCDPGWEGLHCERC--------------------------VRMPGCQ------ 67
           C  D  C C  G+   +CE+                           V +PGC       
Sbjct: 388 CEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447

Query: 68  ------------------HGTCHQ----PWQCICHSGWAGKFCDKDEHI----------C 95
                             HG C       ++ +   G+AG   +K + +          C
Sbjct: 448 LKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANC 507

Query: 96  T-----TQSPCQNGGQCMYDGGGEYH-----CVCLPGFHGRDCE-----RKAG------P 134
           T        P  N   C +   G        C CL     ++       R AG       
Sbjct: 508 TEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENT 567

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD------------------ 176
            +   + C++   C+D+        C C + ++G  C VNVD                  
Sbjct: 568 TDDQENECQHEAVCKDEIN---RPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALS 624

Query: 177 ---------------------DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
                                DC    C NG T       F   C  GF G  C I++D+
Sbjct: 625 HNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDE 684

Query: 216 CASRPCQRGARCRDR--------------VHDFDCLCPSGYGGKTCE 248
           CAS PC+ GA C D+              V  F CLC  GY G  CE
Sbjct: 685 CASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCE 731



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 32/106 (30%), Positives = 45/106 (42%), Gaps = 8/106 (7%)

Query: 169  ARCEVNVDDCLMRPCA-----NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
            AR   N+++C +  CA     N  TC+       C CP  ++G+ C      C + PC  
Sbjct: 2325 ARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGN 2382

Query: 224  GARCRDRV-HDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTS 268
            GA C  +   D  CLCP G  G  C   + +  P  +     G TS
Sbjct: 2383 GATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTS 2428



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 27/69 (39%), Positives = 38/69 (55%), Gaps = 5/69 (7%)

Query: 142  CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCL-DGINRFSCLC 200
            CRNGG+C  +      F+CRCL  + G  C  +V  CL   C + + C+ D    +SCLC
Sbjct: 2884 CRNGGECTVN---GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLC 2939

Query: 201  PEGFAGRFC 209
              G+ GR+C
Sbjct: 2940 TLGWVGRYC 2948



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 6/72 (8%)

Query: 101  CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTC 160
            C+NGG+C  +G   + C CLP + G  C +           C +   C  DQ F+  ++C
Sbjct: 2884 CRNGGECTVNGT-TFSCRCLPDWAGNTCNQSVSCLNNL---CLHQSLCIPDQSFS--YSC 2937

Query: 161  RCLVGFVGARCE 172
             C +G+VG  CE
Sbjct: 2938 LCTLGWVGRYCE 2949



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)

Query: 168  GARCEVNVDDCL-----MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
            GA+   NV DC         C NG  C      FSC C   +AG  C  ++  C +  C 
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCL 2922

Query: 223  RGARC-RDRVHDFDCLCPSGYGGKTCE 248
              + C  D+   + CLC  G+ G+ CE
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)

Query: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235
           C+    CL       +SC C   F+G++C   LD C+ +PC+    C ++  ++D     
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241

Query: 236 CLCPSGYGGKTCELVL 251
           C+C   + GK C  ++
Sbjct: 242 CVCHPPFTGKNCSEII 257



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 24/75 (32%), Positives = 29/75 (38%), Gaps = 7/75 (9%)

Query: 101  CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP---CRNGGQCQDDQGFALN 157
            C NGG C+  G   Y C C  G+ G  C      C+    P   C  G  C         
Sbjct: 2619 CGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS---LPHG 2674

Query: 158  FTCRCLVGFVGARCE 172
            +TC C +G  G  CE
Sbjct: 2675 YTCFCPLGTTGIYCE 2689



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 16/74 (21%)

Query: 38   GCCAPDG---SCRCDPGWEGLHCERCVRMPGCQHGTC-HQP---------WQCICHSGWA 84
            G C  +G   SCRC P W G  C + V    C +  C HQ          + C+C  GW 
Sbjct: 2888 GECTVNGTTFSCRCLPDWAGNTCNQSV---SCLNNLCLHQSLCIPDQSFSYSCLCTLGWV 2944

Query: 85   GKFCDKDEHICTTQ 98
            G++C+      T +
Sbjct: 2945 GRYCENKTSFSTAK 2958



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 21/75 (28%), Positives = 31/75 (41%), Gaps = 11/75 (14%)

Query: 66   CQHGTCHQPWQCI---------CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
            C + TC    +C          C   WAG  C++   +    + C +   C+ D    Y 
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS--VSCLNNLCLHQSLCIPDQSFSYS 2936

Query: 117  CVCLPGFHGRDCERK 131
            C+C  G+ GR CE K
Sbjct: 2937 CLCTLGWVGRYCENK 2951



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 25/89 (28%), Positives = 34/89 (38%), Gaps = 13/89 (14%)

Query: 49   DPGWEGLHCERCVRMPGCQHGTCHQPWQCI---------CHSGWAGKFCDKDEHICTTQS 99
            D    G + E C  +P C H  C     CI         C   ++GK C   +      +
Sbjct: 2323 DEARHGKNIENC-HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC---QFASCENN 2378

Query: 100  PCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
            PC NG  C+   G +  C+C  G  G  C
Sbjct: 2379 PCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 8/82 (9%)

Query: 56   HCERCVRMPGCQHGTCHQPWQ---CICHSGWAGKFCDKDEHICTTQSP----CQNGGQCM 108
            H   C  M     GTC +      C C +GW G FC +    C  +      C  G  C+
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669

Query: 109  YDGGGEYHCVCLPGFHGRDCER 130
                G Y C C  G  G  CE+
Sbjct: 2670 SLPHG-YTCFCPLGTTGIYCEQ 2690



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 17/37 (45%), Positives = 17/37 (45%), Gaps = 5/37 (13%)

Query: 178  CLMRPCANGATC-----LDGINRFSCLCPEGFAGRFC 209
            C    C NG TC       GI  F C CP  F GRFC
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 16/40 (40%), Positives = 19/40 (47%), Gaps = 4/40 (10%)

Query: 98   QSPCQNGGQC----MYDGGGEYHCVCLPGFHGRDCERKAG 133
            Q  C NGG C    +  G   + C C   F GR CE+ AG
Sbjct: 2105 QDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG 2144



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 17/68 (25%), Positives = 24/68 (35%), Gaps = 15/68 (22%)

Query: 38   GCCAPDGS---CRCDPGWEGLHCERCVRMPGCQHGTCH------------QPWQCICHSG 82
            G C   G+   C C  GW+G  C   V     +H   H              + C C  G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682

Query: 83   WAGKFCDK 90
              G +C++
Sbjct: 2683 TTGIYCEQ 2690


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  138 bits (348), Expect = 7e-33
 Identities = 79/252 (31%), Positives = 119/252 (47%), Gaps = 30/252 (11%)

Query: 25   RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMPGCQHG-TCH--- 72
            + + C S     +G C  D      C C   ++G  C      C++ P CQHG TCH   
Sbjct: 916  KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSD 974

Query: 73   ---QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
                 + C C  G+ G+ C+ +   C   + C+N   C+ DG   Y C+C P + G  C+
Sbjct: 975  SHKDGFSCSCPLGFEGQRCEINPDDCE-DNDCENNATCV-DGINNYVCICPPNYTGELCD 1032

Query: 130  RKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
                 C    + C++  +C   D+GF+    C C+ G+ G  CE + DDC+   C +GA 
Sbjct: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFS----CECVPGYSGKLCETDNDDCVAHKCRHGAQ 1088

Query: 189  CLDGINRFSCLCPEGFAGRFC-------TINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
            C+D IN ++C CP+GF+G FC        +    C    CQ GA+C     +  C CP G
Sbjct: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148

Query: 242  YGGKTCELVLPV 253
            + G  CE ++ V
Sbjct: 1149 FAGPRCEKLITV 1160



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 13/119 (10%)

Query: 29   CSSHCDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTC---HQPWQC 77
            C S     HG C         C C PGW G  C++  R P     C HG C      + C
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391

Query: 78   ICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
             C  G+ G  CD         S  + + GQC     GE +C+C PGF G  C+++  PC
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)

Query: 160  CRCLVGFVGARCEVNV-DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD--- 215
            C C  G+ G  C+    D CL   C +G     G + + C C EG+ G  C    D    
Sbjct: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCKCAEGYGGDLCDNKNDSANA 1411

Query: 216  CASRPCQRG-ARCRDRVHDFDCLCPSGYGGKTCE 248
            C++  C  G     D+   + CLC  G+ G+ C+
Sbjct: 1412 CSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  135 bits (339), Expect = 8e-32
 Identities = 74/206 (35%), Positives = 93/206 (45%), Gaps = 14/206 (6%)

Query: 48  CDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
           C PG    +   C     C        + C C   + G FC  +E+    + PCQN   C
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFC--EEYDACQRKPCQNNASC 364

Query: 108 M----YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL 163
           +       G  + CVCLPG+ G  C+ K   C     PCRNG  C         FTC+C 
Sbjct: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYC--ILDPCRNGATCISSLS---GFTCQCP 419

Query: 164 VGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
            G+ G+ CE  VD C   PC N  TC +DG++ F+C C  GF G  C   +D CA  PC 
Sbjct: 420 EGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCA 478

Query: 223 RGARCRDRVHDFDCLCPSGYGGKTCE 248
            G  CR     + CLC  GY G  CE
Sbjct: 479 HGT-CRSVGTSYKCLCDPGYHGLYCE 503



 Score =  130 bits (326), Expect = 3e-30
 Identities = 80/293 (27%), Positives = 111/293 (37%), Gaps = 93/293 (31%)

Query: 45  SCRCDPGWEGLHCER---CVRMPGCQHGTCHQP--------WQCICHSGWAGKFCDKDEH 93
           SC C+  + G  CE    C R P   + +C           + C+C  G+ G+ C     
Sbjct: 335 SCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKID 394

Query: 94  ICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG 153
            C    PC+NG  C+    G + C C  G+ G  CE K  PC  A SPC+N G C  D  
Sbjct: 395 YCILD-PCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPC--ASSPCQNNGTCYVD-- 448

Query: 154 FALNFTCRCLVGFVGARCEVNVD------------------------------------- 176
             ++FTC C  GF G  C   +D                                     
Sbjct: 449 -GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYN 507

Query: 177 DCLMRPCANGATCLDGINRF--------------------------------------SC 198
           +CL  PC N ATC D +N +                                      +C
Sbjct: 508 ECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTC 567

Query: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
           +C  GF G  C I++++C S PC  G  C D+ + ++C CP G+ G  CE+ L
Sbjct: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 16/113 (14%)

Query: 178 CLMRPCANGATCLD------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
           C  +PC NG  C              G   +SC CP G +G  C +  D CAS PC  G 
Sbjct: 48  CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107

Query: 226 RCRDRVHDFD---CLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPAT 275
                    D   C+C  GY G  CE  LP   P T     + P     VPAT
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP-SLPATGWTESMAPRQLQPVPAT 159



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 31/89 (34%), Positives = 42/89 (47%), Gaps = 14/89 (15%)

Query: 133 GPCEQAGSPCRNGGQCQ-----DDQGFAL----NFTCRCLVGFVGARCEVNVDDCLMRPC 183
           GPC  A  PCRNGG C      D Q  A      ++C C  G  GA C++  D C   PC
Sbjct: 46  GPC--AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103

Query: 184 ANG---ATCLDGINRFSCLCPEGFAGRFC 209
            +G   ++     + + C+C EG+ G  C
Sbjct: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNC 132



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 14/89 (15%)

Query: 95  CTTQSPCQNGGQCMYD-----------GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
           C  Q PC+NGG C              G   Y C C  G  G +C+  A PC  A +PC 
Sbjct: 48  CAAQ-PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCH 104

Query: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCE 172
           +G         +  + C C  G+ G  CE
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133



 Score = 36.2 bits (82), Expect = 0.051
 Identities = 34/129 (26%), Positives = 48/129 (37%), Gaps = 19/129 (14%)

Query: 10  LVCLLCILGAP------GQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
           L  LL +LGA         PV A   S+    A   C   G C   P  +  H       
Sbjct: 17  LALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQH-----PA 71

Query: 64  PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGE--YHCVCLP 121
           P  + G     + C C +G +G  C      C + +PC +G            Y C+C  
Sbjct: 72  PAGEPG-----YSCTCPAGISGANCQLVADPCAS-NPCHHGNCSSSSSSSSDGYLCICNE 125

Query: 122 GFHGRDCER 130
           G+ G +CE+
Sbjct: 126 GYEGPNCEQ 134



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 9/67 (13%)

Query: 2   PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGS-------CRCDPGWEG 54
           P+G       C   I GA  Q V AD C+S+    HG C+   S       C C+ G+EG
Sbjct: 72  PAGEPGYSCTCPAGISGANCQLV-ADPCASN-PCHHGNCSSSSSSSSDGYLCICNEGYEG 129

Query: 55  LHCERCV 61
            +CE+ +
Sbjct: 130 PNCEQAL 136


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score =  126 bits (316), Expect = 4e-29
 Identities = 99/352 (28%), Positives = 135/352 (38%), Gaps = 102/352 (28%)

Query: 29  CSSHCDLAH-GCCAPD-GSCRCDPGWEGLHC----------ERCVRMPGCQHGTCHQP-- 74
           C++ C  AH   C+P  G+C C PGW G HC          E C     C H     P  
Sbjct: 490 CNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVH 549

Query: 75  WQCICHSGWAGKFCDKDEHI----------CTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
            +C C +GW G  C    H+          C+    C+NGG C+ + G   +CVC PGF 
Sbjct: 550 GRCQCQAGWMGARC----HLSCPEGLWGVNCSNTCTCKNGGTCLPENG---NCVCAPGFR 602

Query: 125 GRDCERKAGPCEQ----AGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV----- 175
           G  C+R   P           C N   C    G     TC CL G+ G  C         
Sbjct: 603 GPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG-----TCYCLAGWTGPDCSQPCPPGHW 657

Query: 176 -DDCLMR-PCANGATC--LDGINRFSCLCPEGFAGRFCTINLDDC--------ASRPCQR 223
            ++C     C +G TC   DG    SC+CP G+ G  C   L+ C         S+PCQ 
Sbjct: 658 GENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHC---LEGCPLGTFGANCSQPCQC 710

Query: 224 GARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAG 283
           G   +       C+CP G+ G  C + +  P                V+P T  A +S G
Sbjct: 711 GPGEKCHPETGACVCPPGHSGAPCRIGIQEP--------------FTVMPTTPVAYNSLG 756

Query: 284 AGLLRISVKEVVRRQEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRG 335
           A                      ++ + V G+L  ALV   + +  R W++G
Sbjct: 757 A----------------------VIGIAVLGSLVVALV--ALFIGYRHWQKG 784



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 81/297 (27%), Positives = 106/297 (35%), Gaps = 64/297 (21%)

Query: 1   MPSGCRCLH-LVCLLCILGAPGQPVRADDCSSHCDLAHG--CCAPDGSCRCDPGW----- 52
           M   C CL     L C    P Q      C  HC   HG  C A  G C+C PG+     
Sbjct: 376 MNGECSCLPGWAGLHCNESCP-QDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHC 434

Query: 53  --------EGLHCE-RCVRMPGCQHGTCHQP--WQCICHSGWAGKFCDKD------EHIC 95
                    G++C  RC     C++     P   +C+C  GW    C            C
Sbjct: 435 ASLCPPDTYGVNCSARC----SCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSC 490

Query: 96  TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF- 154
                C +   C    G    C C PG+HG  C+    P  Q G  C +   C    G  
Sbjct: 491 NASCQCAHEAVCSPQTGA---CTCTPGWHGAHCQLPC-PKGQFGEGCASRCDCDHSDGCD 546

Query: 155 ALNFTCRCLVGFVGARCEVNVDDCLMR-------PCANGATCLDGINRFSCLCPEGFAGR 207
            ++  C+C  G++GARC ++  + L          C NG TCL      +C+C  GF G 
Sbjct: 547 PVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLP--ENGNCVCAPGFRGP 604

Query: 208 FCTINLDDCASRPCQRG------ARCRDRVHDF------DCLCPSGYGGKTCELVLP 252
            C         R CQ G        C+   H F       C C +G+ G  C    P
Sbjct: 605 SC--------QRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCP 653



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 91/308 (29%), Positives = 107/308 (34%), Gaps = 74/308 (24%)

Query: 7   CLHLVCLLCILG---APGQPV-----RADDCSSHC---------DLAHGC-----CAP-D 43
           C+ L    C+ G   AP Q       R DDCSS C         D    C     C P  
Sbjct: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS 160

Query: 44  GSCRCDPGWEGLHC-ERCVRM---PGCQHGT-CH------QPWQCICHSGWAGKFCD--- 89
           G C C  G +  +C + C      P CQ    CH      Q   C C +   G  CD   
Sbjct: 161 GVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSC 220

Query: 90  ---KDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC-----ERKAGPCEQAGSP 141
                   C +   CQNGG      G    C C PG+ G  C     E   GP       
Sbjct: 221 SQGTSGFFCPSTHSCQNGGVFQTPQGS---CSCPPGWMGTICSLPCPEGFHGPNCSQECR 277

Query: 142 CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM----RPCANGATCLDGINRF- 196
           C NGG C    G      CRC  G+ G RC    ++C +    + CA    C      F 
Sbjct: 278 CHNGGLCDRFTG-----QCRCAPGYTGDRCR---EECPVGRFGQDCAETCDCAPDARCFP 329

Query: 197 ---SCLCPEGFAGRFCTINL--DDCASRPCQRGARCRDRVHDF-------DCLCPSGYGG 244
              +CLC  GF G  CT  L  D      CQ    C DR H         +C C  G+ G
Sbjct: 330 ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC-DREHSLSCHPMNGECSCLPGWAG 388

Query: 245 KTCELVLP 252
             C    P
Sbjct: 389 LHCNESCP 396



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 59/215 (27%), Positives = 79/215 (36%), Gaps = 42/215 (19%)

Query: 66  CQHGTCHQPWQCICHSGWAGKFCDKD------EHICTTQSPCQNGGQCMYDGG------- 112
           C HG C  P QC C  GW G  C  +         C     C N   C    G       
Sbjct: 109 CVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSG 168

Query: 113 -GEYHCV--CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGA 169
               +C+  C PG++G  C+ +   C+  G+PC       D Q  A    C C     G 
Sbjct: 169 LQPPNCLQPCTPGYYGPACQFR---CQCHGAPC-------DPQTGA----CFCPAERTGP 214

Query: 170 RCEVNVDDCLMR-PCANGATCLDG----INRFSCLCPEGFAGRFCTINLDDCASRP-CQR 223
            C+V+         C +  +C +G      + SC CP G+ G  C++   +    P C +
Sbjct: 215 SCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQ 274

Query: 224 GARCR-----DRVHDFDCLCPSGYGGKTCELVLPV 253
             RC      DR     C C  GY G  C    PV
Sbjct: 275 ECRCHNGGLCDRFTG-QCRCAPGYTGDRCREECPV 308


>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
          Length = 236

 Score =  125 bits (313), Expect = 8e-29
 Identities = 70/209 (33%), Positives = 95/209 (45%), Gaps = 23/209 (11%)

Query: 44  GSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCI-----------CHSGWAGKFCD-KD 91
           G C+C  G+ G +C+   R P C+   C     C+           C SG+ G+ C    
Sbjct: 10  GYCKCPEGFLGEYCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66

Query: 92  EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD 151
            H C    PC NGG C       Y C C  GF G++C+     C     PC NG  C   
Sbjct: 67  SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC--LSHPCANGSTCTT- 122

Query: 152 QGFALNFTCRCLVGFVGARCEVNVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
              A  F+C+CL GF G +CE +V++C +   C +G TCL+    + C C +GF G++C 
Sbjct: 123 --VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180

Query: 211 INLDDCASRPCQRGARCRDR-VHDFDCLC 238
                CA  PC  G  CR      F+C C
Sbjct: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209



 Score =  118 bits (296), Expect = 8e-27
 Identities = 66/185 (35%), Positives = 90/185 (48%), Gaps = 10/185 (5%)

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG-GEYHCVCLPGFHGRDCERKAG-P 134
           C C  G+ G++C   +     ++ CQNGG C+     G+  C C  GF G DC+     P
Sbjct: 12  CKCPEGFLGEYCQHRDPC--EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69

Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
           C     PC NGG C         + C C VGF G  C+   D CL  PCANG+TC    N
Sbjct: 70  CF-VSRPCLNGGTCH--MLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125

Query: 195 RFSCLCPEGFAGRFCTINLDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE-LVLP 252
           +FSC C  GF G+ C  ++++C     CQ G  C +    + C C  G+ G+ C+ L +P
Sbjct: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185

Query: 253 VPDPP 257
               P
Sbjct: 186 CAPSP 190



 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 53/145 (36%), Positives = 72/145 (49%), Gaps = 8/145 (5%)

Query: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
           C+    G  +C C  GF G  C+ +  PCE+  + C+NGG C   Q      TCRC  GF
Sbjct: 2   CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEK--NRCQNGGTCV-AQAMLGKATCRCASGF 57

Query: 167 VGARCEVNVD-DCLM-RPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
            G  C+ +    C + RPC NG TC +   + + C C  GF G+ C    D C S PC  
Sbjct: 58  TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCAN 116

Query: 224 GARCRDRVHDFDCLCPSGYGGKTCE 248
           G+ C    + F C C +G+ G+ CE
Sbjct: 117 GSTCTTVANQFSCKCLTGFTGQKCE 141



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 45/119 (37%), Positives = 58/119 (48%), Gaps = 13/119 (10%)

Query: 15  CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
           C +G  G+  +  D C SH C     C   A   SC+C  G+ G  CE  V    +PG C
Sbjct: 94  CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 153

Query: 67  QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
           QHG TC      +QC C  G+ G++CD   ++    SPC NGG C   G   + C CLP
Sbjct: 154 QHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  121 bits (304), Expect = 9e-28
 Identities = 61/179 (34%), Positives = 83/179 (46%), Gaps = 26/179 (14%)

Query: 92   EHICTTQSPCQNGGQCMY---------------------DGGGEYHCVCLPGFHGRDCER 130
            +H      PCQNGG C+                      +    + C CLPG+ G  CE 
Sbjct: 3802 DHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEI 3861

Query: 131  KAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCL 190
                C    SPC +GG C +  G    F+C C  GF G  CE ++++CL  PC NGA C 
Sbjct: 3862 DIDEC--LPSPCHSGGTCHNLVG---GFSCSCPDGFTGRACERDINECLQSPCKNGAICQ 3916

Query: 191  DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
            +    F+C+C  G+ G+ C  +++ C   PC  G  C+  V  + C CP G  GK CEL
Sbjct: 3917 NFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCEL 3975



 Score =  118 bits (296), Expect = 8e-27
 Identities = 59/140 (42%), Positives = 77/140 (55%), Gaps = 7/140 (5%)

Query: 73   QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
            QP+ C C  G+AG +C+ D   C   SPC +GG C    GG + C C  GF GR CER  
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDIDECLP-SPCHSGGTCHNLVGG-FSCSCPDGFTGRACERDI 3901

Query: 133  GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
              C Q  SPC+NG  CQ+  G   +F C C  G+ G  CE +V+ C   PC NG +C  G
Sbjct: 3902 NECLQ--SPCKNGAICQNFPG---SFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSG 3956

Query: 193  INRFSCLCPEGFAGRFCTIN 212
            ++ + C CP G  G+ C +N
Sbjct: 3957 VDSYYCHCPFGVFGKHCELN 3976



 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 51/136 (37%), Positives = 70/136 (51%), Gaps = 14/136 (10%)

Query: 46   CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQ 98
            C+C PG+ G  CE     C+  P    GTCH     + C C  G+ G+ C++D + C  Q
Sbjct: 3848 CKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC-LQ 3906

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            SPC+NG  C  +  G ++CVC  G+ G+ CE     CE   +PC NGG CQ       ++
Sbjct: 3907 SPCKNGAICQ-NFPGSFNCVCKTGYTGKMCESSVNYCE--CNPCFNGGSCQSGVD---SY 3960

Query: 159  TCRCLVGFVGARCEVN 174
             C C  G  G  CE+N
Sbjct: 3961 YCHCPFGVFGKHCELN 3976



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 41/131 (31%), Positives = 57/131 (43%), Gaps = 25/131 (19%)

Query: 143  RNGGQCQDDQGFALNFTC--RCLVGFVGARCE-VNVDDCLMRPCANGATCL--------- 190
            RN  Q  +  G A  F      L+   G + E V+ D C+  PC NG +CL         
Sbjct: 3768 RNHNQYVNPSGVATFFESIKEILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVL 3827

Query: 191  -------------DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCL 237
                         + +  F C C  G+AG +C I++D+C   PC  G  C + V  F C 
Sbjct: 3828 KSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCS 3887

Query: 238  CPSGYGGKTCE 248
            CP G+ G+ CE
Sbjct: 3888 CPDGFTGRACE 3898



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 16/128 (12%)

Query: 15   CILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG--SCRCDPGWEGLHCER----CVRMPG 65
            C+ G  G    +  D+C  S C     C    G  SC C  G+ G  CER    C++ P 
Sbjct: 3850 CLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP- 3908

Query: 66   CQHGTCHQ----PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
            C++G   Q     + C+C +G+ GK C+   + C   +PC NGG C   G   Y+C C  
Sbjct: 3909 CKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCEC-NPCFNGGSCQ-SGVDSYYCHCPF 3966

Query: 122  GFHGRDCE 129
            G  G+ CE
Sbjct: 3967 GVFGKHCE 3974



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 34/104 (32%), Positives = 43/104 (41%), Gaps = 16/104 (15%)

Query: 178  CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD-FDC 236
            C   PC     C++    + C+ P             DCAS PCQ G  C   +H  F C
Sbjct: 4404 CASNPCWGDLLCINQWYAYRCVPP------------GDCASHPCQNGGSCEPGLHSGFTC 4451

Query: 237  LCPSGYGGKTCELV---LPVPDPPTTVDTPLGPTSAVVVPATGP 277
             CP  + G+TCE+V   L V  P   V     P   V V + GP
Sbjct: 4452 SCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAGHVCVLSQGP 4495



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 3/68 (4%)

Query: 162  CLVGFVGARCEVNVDDCLMRPCANGATCLDGINR-FSCLCPEGFAGRFCTINLDDCASRP 220
            C+  +   RC V   DC   PC NG +C  G++  F+C CP+   GR C + +  C    
Sbjct: 4415 CINQWYAYRC-VPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEM-VVACLGVL 4472

Query: 221  CQRGARCR 228
            C +G  C+
Sbjct: 4473 CPQGKVCK 4480



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 3/59 (5%)

Query: 134  PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
            P + A  PC+NGG C+   G    FTC C     G  CE+ V  CL   C  G  C  G
Sbjct: 4427 PGDCASHPCQNGGSCEP--GLHSGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAG 4482



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 3/62 (4%)

Query: 73   QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
            +P Q +   G   + C + E  CT +SPCQ+GG CM D      C C  G  G+ CE+  
Sbjct: 4145 EPSQALAAQGILDQ-CPRLEGACT-RSPCQHGGTCM-DYWSWQQCHCKEGLTGKYCEKSV 4201

Query: 133  GP 134
             P
Sbjct: 4202 TP 4203



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 13/32 (40%), Positives = 18/32 (56%)

Query: 178  CLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
            C   PC +G TC+D  +   C C EG  G++C
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYC 4197



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 18/48 (37%), Positives = 23/48 (47%), Gaps = 5/48 (10%)

Query: 128  CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
            C R  G C +  SPC++GG C D   +     C C  G  G  CE +V
Sbjct: 4159 CPRLEGACTR--SPCQHGGTCMDYWSWQ---QCHCKEGLTGKYCEKSV 4201



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 14/33 (42%), Positives = 14/33 (42%)

Query: 216  CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            C   PCQ G  C D      C C  G  GK CE
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 34/125 (27%), Positives = 39/125 (31%), Gaps = 36/125 (28%)

Query: 38   GCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTT 97
            GC  P+  C  +P W  L C     +       C  P  C  H                 
Sbjct: 4397 GCRGPN-ICASNPCWGDLLC-----INQWYAYRCVPPGDCASH----------------- 4433

Query: 98   QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCER---------KAGPCEQAGSPCRNGGQC 148
              PCQNGG C       + C C     GR CE            G   +AGSP   G  C
Sbjct: 4434 --PCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPA--GHVC 4489

Query: 149  QDDQG 153
               QG
Sbjct: 4490 VLSQG 4494


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  121 bits (303), Expect = 1e-27
 Identities = 62/178 (34%), Positives = 82/178 (46%), Gaps = 6/178 (3%)

Query: 99   SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
            +PCQNGG C     G Y+C C   + G  CE    PC  +  PC  GG C  D G    F
Sbjct: 4020 NPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPC--SSKPCLYGGTCVVDNG---GF 4074

Query: 159  TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
             C+C   + G RC+++   C   PC NG TC D ++   C C  GF G  C  ++D+C+ 
Sbjct: 4075 VCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSG 4133

Query: 219  RPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATG 276
             PC  GA C +    + C C   Y G+ CE   P     T  +  L     +VV   G
Sbjct: 4134 NPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAG 4191



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 52/157 (33%), Positives = 79/157 (50%), Gaps = 14/157 (8%)

Query: 58   ERCVRMPGCQHGTCHQP-----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
            E C   P CQ+G    P     + C C + + G  C+   + C+++ PC  GG C+ D G
Sbjct: 4015 EDCASNP-CQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSK-PCLYGGTCVVDNG 4072

Query: 113  GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
            G + C C   + G+ C+  +  C+    PC+NGG C D    A+   C+C  GF G RC+
Sbjct: 4073 G-FVCQCRGLYTGQRCQ-LSPYCKD--EPCKNGGTCFDSLDGAV---CQCDSGFRGERCQ 4125

Query: 173  VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
             ++D+C   PC +GA C +    + C C   + GR C
Sbjct: 4126 SDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHC 4162



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 19/157 (12%)

Query: 27   DDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPW 75
            +DC+S+     G C P  +    C+C   + G HCE     C   P    GTC   +  +
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGF 4074

Query: 76   QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
             C C   + G+ C    +      PC+NGG C +D      C C  GF G  C+     C
Sbjct: 4075 VCQCRGLYTGQRCQLSPY--CKDEPCKNGGTC-FDSLDGAVCQCDSGFRGERCQSDIDEC 4131

Query: 136  EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
              +G+PC +G  C++  G   ++ C C   + G  CE
Sbjct: 4132 --SGNPCLHGALCENTHG---SYHCNCSHEYRGRHCE 4163



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 1/83 (1%)

Query: 176  DDCLMRPCANGATCLDG-INRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
            +DC   PC NG  C       + C C   + G  C I+++ C+S+PC  G  C      F
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGF 4074

Query: 235  DCLCPSGYGGKTCELVLPVPDPP 257
             C C   Y G+ C+L     D P
Sbjct: 4075 VCQCRGLYTGQRCQLSPYCKDEP 4097



 Score = 32.0 bits (71), Expect = 0.96
 Identities = 19/56 (33%), Positives = 24/56 (42%), Gaps = 6/56 (10%)

Query: 72   HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH-CVCLPGFHGR 126
            H+   C+C  G     C    H C    PC  G +C+ D   E H CVC  G  G+
Sbjct: 3775 HRAAVCLCKEGR----CPPVHHGCE-DDPCPEGSECVSDPWEEKHTCVCPSGRFGQ 3825


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score =  114 bits (286), Expect = 1e-25
 Identities = 79/246 (32%), Positives = 105/246 (42%), Gaps = 33/246 (13%)

Query: 4    GCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
            G  CL      C  G  G       C+ HC+    C  PD  C+C PGW G  C   +  
Sbjct: 1369 GGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPD-ICQCKPGWYGPTCSTALCD 1427

Query: 64   PGCQH-GTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
            P C + G+C++P  C+C +G+ G+ C           PC+NGG CM +      CVC  G
Sbjct: 1428 PVCLNGGSCNKPNTCLCPNGFFGEHCQN----AFCHPPCKNGGHCMRNN----VCVCREG 1479

Query: 123  FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
            + GR  ++    C+     C NGG+C          TC C  G+ G RC  N   CL + 
Sbjct: 1480 YTGRRFQKSI--CDPT---CMNGGKCVGPS------TCSCPSGWSGKRC--NTPICLQK- 1525

Query: 183  CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
            C NG  C   I    C CP  + G  C I +    +  C  G RC   +    C C + Y
Sbjct: 1526 CKNGGEC---IAPSICHCPSSWEGVRCQIPI---CNPKCLYGGRC---IFPNVCSCRTEY 1576

Query: 243  GGKTCE 248
             G  CE
Sbjct: 1577 SGVKCE 1582



 Score =  108 bits (271), Expect = 6e-24
 Identities = 73/219 (33%), Positives = 96/219 (43%), Gaps = 35/219 (15%)

Query: 29   CSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQ-HGTCHQPWQCICHSGWAGKF 87
            C   C  +  C AP+  C+C PG+ G +C+  +  P C+ HG C +P  C C  G  G  
Sbjct: 1298 CKYPCGKSRECVAPN-ICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGAT 1356

Query: 88   CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQ 147
            CD +EH      PCQ+GG C+        C C  GF G  CE            C NGGQ
Sbjct: 1357 CD-EEH---CNPPCQHGGTCLAGN----LCTCPYGFVGPRCETMV-----CNRHCENGGQ 1403

Query: 148  CQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGR 207
            C           C+C  G+ G  C   + D +   C NG +C       +CLCP GF G 
Sbjct: 1404 CLTPD------ICQCKPGWYGPTCSTALCDPV---CLNGGSC---NKPNTCLCPNGFFGE 1451

Query: 208  FCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGK 245
             C    +     PC+ G  C R+ V    C+C  GY G+
Sbjct: 1452 HCQ---NAFCHPPCKNGGHCMRNNV----CVCREGYTGR 1483



 Score =  106 bits (265), Expect = 3e-23
 Identities = 76/234 (32%), Positives = 96/234 (41%), Gaps = 33/234 (14%)

Query: 15   CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQH-GTCHQ 73
            C  G  G   +   C   C   HG C     C+C PG  G  C+     P CQH GTC  
Sbjct: 1316 CKPGYIGSNCQTALCDPDCK-NHGKCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTCLA 1374

Query: 74   PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG 133
               C C  G+ G  C  +  +C     C+NGGQC+        C C PG++G  C     
Sbjct: 1375 GNLCTCPYGFVGPRC--ETMVCNRH--CENGGQCLTPD----ICQCKPGWYGPTC--STA 1424

Query: 134  PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
             C+     C NGG C          TC C  GF G  C+   +     PC NG  C+   
Sbjct: 1425 LCDPV---CLNGGSCNKPN------TCLCPNGFFGEHCQ---NAFCHPPCKNGGHCM--- 1469

Query: 194  NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
                C+C EG+ GR    ++ D     C  G +C   V    C CPSG+ GK C
Sbjct: 1470 RNNVCVCREGYTGRRFQKSICD---PTCMNGGKC---VGPSTCSCPSGWSGKRC 1517



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 42/155 (27%), Positives = 58/155 (37%), Gaps = 45/155 (29%)

Query: 142  CRNGGQCQDDQGFALN---FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
            C NGG C  D+ F+     + C CL GF G+ CEV++  C   PC  G + + G + +SC
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLG-SYISGFHSYSC 1241

Query: 199  LCP------EGFAGRFCT-----------INLDD---------------------CASRP 220
             CP        F  +F T           +N ++                         P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301

Query: 221  CQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPD 255
            C +   C   V    C C  GY G  C+  L  PD
Sbjct: 1302 CGKSREC---VAPNICKCKPGYIGSNCQTALCDPD 1333



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 50/187 (26%), Positives = 66/187 (35%), Gaps = 50/187 (26%)

Query: 101  CQNGGQCMYD-----GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGG--------- 146
            C NGG C+ D     G G Y CVCLPGFHG  CE     C+   +PC  G          
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQ--SNPCGLGSYISGFHSYS 1240

Query: 147  -----QCQDDQGFALNFTCRCLV---------------GFVGARCEV-----NVDDCLMR 181
                 + + +  F   FT + +V                  G +  V     N       
Sbjct: 1241 CDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKY 1300

Query: 182  PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
            PC     C   +    C C  G+ G  C   L D     C+   +C   +    C C  G
Sbjct: 1301 PCGKSREC---VAPNICKCKPGYIGSNCQTALCD---PDCKNHGKC---IKPNICQCLPG 1351

Query: 242  YGGKTCE 248
            +GG TC+
Sbjct: 1352 HGGATCD 1358



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 57/243 (23%), Positives = 83/243 (34%), Gaps = 54/243 (22%)

Query: 33   CD-LAHGCCAPDGS---------CRCDPGWEGLHCERCVRMPGCQHGTC--------HQP 74
            CD L  G C  D +         C C PG+ G  CE  V + GCQ   C           
Sbjct: 1181 CDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCE--VDISGCQSNPCGLGSYISGFHS 1238

Query: 75   WQCIC------HSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
            + C C       + +  +F  +   +  +              G + H     G     C
Sbjct: 1239 YSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTIC 1298

Query: 129  ERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
            +           PC    +C      A N  C+C  G++G+ C+  + D     C N   
Sbjct: 1299 KY----------PCGKSREC-----VAPNI-CKCKPGYIGSNCQTALCD---PDCKNHGK 1339

Query: 189  CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
            C   I    C C  G  G  C    ++  + PCQ G  C   +    C CP G+ G  CE
Sbjct: 1340 C---IKPNICQCLPGHGGATCD---EEHCNPPCQHGGTC---LAGNLCTCPYGFVGPRCE 1390

Query: 249  LVL 251
             ++
Sbjct: 1391 TMV 1393



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 2/89 (2%)

Query: 3    SGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVR 62
            +G +C+      C  G  G+      C   C     C AP   C C   WEG+ C+  + 
Sbjct: 1496 NGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPS-ICHCPSSWEGVRCQIPIC 1554

Query: 63   MPGCQH-GTCHQPWQCICHSGWAGKFCDK 90
             P C + G C  P  C C + ++G  C+K
Sbjct: 1555 NPKCLYGGRCIFPNVCSCRTEYSGVKCEK 1583



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 10/74 (13%)

Query: 172  EVNVDDCLMRPCANGATCLD------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
            EV V  C    C NG +C+       G   + C+C  GF G  C +++  C S PC  G+
Sbjct: 1175 EVTVKSC---DCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGS 1231

Query: 226  RCRDRVHDFDCLCP 239
                  H + C CP
Sbjct: 1232 YI-SGFHSYSCDCP 1244



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 12/28 (42%), Positives = 13/28 (46%), Gaps = 5/28 (17%)

Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
           C   GQCM     E+ C C P F   DC
Sbjct: 894 CSGNGQCM-----EWGCACSPSFSSYDC 916


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  107 bits (268), Expect = 1e-23
 Identities = 84/259 (32%), Positives = 109/259 (42%), Gaps = 60/259 (23%)

Query: 2   PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
           P GC    RC    C+ C  G  G       C   C     C   +G C C+PG+ G  C
Sbjct: 250 PRGCSQRGRCEGGRCV-CDPGYTGDDCGMRSCPRGCSQRGRC--ENGRCVCNPGYTGEDC 306

Query: 58  --ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSP--CQNGGQCMYDGG 112
               C R  GC Q G C +  +C+C  G+ G+ C       T   P  C  GG+C+ DG 
Sbjct: 307 GVRSCPR--GCSQRGRC-KDGRCVCDPGYTGEDCG------TRSCPWDCGEGGRCV-DG- 355

Query: 113 GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
               CVC PG+ G DC  +  P +     CR  G+C+D +       C C  G+ G    
Sbjct: 356 ---RCVCWPGYTGEDCSTRTCPRD-----CRGRGRCEDGE-------CICDTGYSG---- 396

Query: 173 VNVDDCLMRPCANGAT----CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
              DDC +R C         C DG     C+C  G+ G        DC SR C R  R R
Sbjct: 397 ---DDCGVRSCPGDCNQRGRCEDG----RCVCWPGYTGT-------DCGSRACPRDCRGR 442

Query: 229 DRVHDFDCLCPSGYGGKTC 247
            R  +  C+C +GY G+ C
Sbjct: 443 GRCENGVCVCNAGYSGEDC 461



 Score =  105 bits (262), Expect = 7e-23
 Identities = 74/247 (29%), Positives = 106/247 (42%), Gaps = 48/247 (19%)

Query: 6   RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
           RC    C+ C  G  G       C   C+    C   DG C C PG+ G  C        
Sbjct: 382 RCEDGECI-CDTGYSGDDCGVRSCPGDCNQRGRC--EDGRCVCWPGYTGTDCGSRACPRD 438

Query: 66  CQ-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
           C+  G C     C+C++G++G+ C     + +    C+  G+C  + G    C+C PG+ 
Sbjct: 439 CRGRGRCENG-VCVCNAGYSGEDCG----VRSCPGDCRGRGRC--ESG---RCMCWPGYT 488

Query: 125 GRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCA 184
           GRDC  +A P +     CR  G+C D +       C C  GF G       +DC  R C 
Sbjct: 489 GRDCGTRACPGD-----CRGRGRCVDGR-------CVCNPGFTG-------EDCGSRRCP 529

Query: 185 NGAT----CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
                   C DG+    C+C  G++G       +DC++R C  G R R +  D  C+C  
Sbjct: 530 GDCRGHGLCEDGV----CVCDAGYSG-------EDCSTRSCPGGCRGRGQCLDGRCVCED 578

Query: 241 GYGGKTC 247
           GY G+ C
Sbjct: 579 GYSGEDC 585



 Score =  103 bits (256), Expect = 3e-22
 Identities = 73/245 (29%), Positives = 100/245 (40%), Gaps = 44/245 (17%)

Query: 6   RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
           RC+   C+ C  G  G       C   C    G C   G C C  G+ G  C +     G
Sbjct: 196 RCVRGRCV-CFPGYTGPSCGWPSCPGDCQ-GRGRCV-QGVCVCRAGFSGPDCSQRSCPRG 252

Query: 66  C-QHGTCHQPWQCICHSGWAGKFCDKDE--HICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
           C Q G C +  +C+C  G+ G  C        C+ +  C+NG            CVC PG
Sbjct: 253 CSQRGRC-EGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENG-----------RCVCNPG 300

Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
           + G DC  ++ P       C   G+C+D +       C C  G+ G  C      C    
Sbjct: 301 YTGEDCGVRSCP-----RGCSQRGRCKDGR-------CVCDPGYTGEDCGTR--SCPW-D 345

Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
           C  G  C+DG     C+C  G+ G       +DC++R C R  R R R  D +C+C +GY
Sbjct: 346 CGEGGRCVDG----RCVCWPGYTG-------EDCSTRTCPRDCRGRGRCEDGECICDTGY 394

Query: 243 GGKTC 247
            G  C
Sbjct: 395 SGDDC 399



 Score =  101 bits (251), Expect = 1e-21
 Identities = 80/256 (31%), Positives = 101/256 (39%), Gaps = 39/256 (15%)

Query: 2   PSGCR----CLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
           P  CR    C   VC+ C  G  G+      C   C    G C  DG C C+ G+ G  C
Sbjct: 529 PGDCRGHGLCEDGVCV-CDAGYSGEDCSTRSCPGGCR-GRGQCL-DGRCVCEDGYSGEDC 585

Query: 58  ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
                   C QHG C Q   CIC  G+  + C     I T  S C   G+C      E  
Sbjct: 586 GVRQCPNDCSQHGVC-QDGVCICWEGYVSEDCS----IRTCPSNCHGRGRCE-----EGR 635

Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
           C+C PG+ G  C  +  P +     CR  G+C   QG      C C VG+ G  C    +
Sbjct: 636 CLCDPGYTGPTCATRMCPAD-----CRGRGRCV--QG-----VCLCHVGYGGEDC--GQE 681

Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
           +     C  G    +      C+C EGF G        DCA + C    R R   HD  C
Sbjct: 682 EPPASACPGGCGPRELCRAGQCVCVEGFRG-------PDCAIQTCPGDCRGRGECHDGSC 734

Query: 237 LCPSGYGGKTCELVLP 252
           +C  GY G+ C   +P
Sbjct: 735 VCKDGYAGEDCGEEVP 750



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 62/218 (28%), Positives = 85/218 (38%), Gaps = 50/218 (22%)

Query: 45  SCRCDPGWEGLHC------ERCVRMPGCQHGTCHQP---------WQCICHSGWAGKFCD 89
           +C C+PGW G  C      E     P    G+C             +C+C  G+ G  C 
Sbjct: 155 TCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCG 214

Query: 90  KDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ 149
                 +    CQ  G+C+     +  CVC  GF G DC +++ P       C   G+C+
Sbjct: 215 WP----SCPGDCQGRGRCV-----QGVCVCRAGFSGPDCSQRSCP-----RGCSQRGRCE 260

Query: 150 DDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
             +       C C  G+ G       DDC MR C  G +         C+C  G+ G   
Sbjct: 261 GGR-------CVCDPGYTG-------DDCGMRSCPRGCSQRGRCENGRCVCNPGYTG--- 303

Query: 210 TINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
               +DC  R C RG   R R  D  C+C  GY G+ C
Sbjct: 304 ----EDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDC 337


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  103 bits (257), Expect = 3e-22
 Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 43/251 (17%)

Query: 2   PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
           PS C    +C++ VC+ C  G  G     + C   C   HG C  DG C C  G+ G  C
Sbjct: 222 PSDCNDQGKCVNGVCI-CFEGYAGADCSREICPVPCSEEHGTCV-DGLCVCHDGFAGDDC 279

Query: 58  ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
            + + +  C   G C +  +C+C  G+ G+ C   E IC   + C + G+C+        
Sbjct: 280 NKPLCLNNCYNRGRCVEN-ECVCDEGFTGEDC--SELIC--PNDCFDRGRCI-----NGT 329

Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
           C C  GF G DC +   P       C   G+C++ Q       C C  GF G  C    +
Sbjct: 330 CYCEEGFTGEDCGKPTCP-----HACHTQGRCEEGQ-------CVCDEGFAGVDCS---E 374

Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
                 C N   C+DG     C C +GF G        DC    C  G     R  +  C
Sbjct: 375 KRCPADCHNRGRCVDG----RCECDDGFTGA-------DCGELKCPNGCSGHGRCVNGQC 423

Query: 237 LCPSGYGGKTC 247
           +C  GY G+ C
Sbjct: 424 VCDEGYTGEDC 434



 Score =  103 bits (256), Expect = 3e-22
 Identities = 73/244 (29%), Positives = 98/244 (40%), Gaps = 40/244 (16%)

Query: 6   RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
           RC    C+ C  G  G       C + C     C   DG C CD G+ G  C       G
Sbjct: 355 RCEEGQCV-CDEGFAGVDCSEKRCPADCHNRGRCV--DGRCECDDGFTGADCGELKCPNG 411

Query: 66  CQ-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
           C  HG C    QC+C  G+ G+ C +        + C + G+C+     E  CVC  GF 
Sbjct: 412 CSGHGRCVNG-QCVCDEGYTGEDCSQ----LRCPNDCHSRGRCV-----EGKCVCEQGFK 461

Query: 125 GRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCA 184
           G DC   + P     + C   G+C       +N  C C  G+ G  C    D    R C+
Sbjct: 462 GYDCSDMSCP-----NDCHQHGRC-------VNGMCVCDDGYTGEDCR---DRQCPRDCS 506

Query: 185 NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGG 244
           N   C+DG     C+C +GF G        DCA   C      + R  +  C+C  G+ G
Sbjct: 507 NRGLCVDG----QCVCEDGFTG-------PDCAELSCPNDCHGQGRCVNGQCVCHEGFMG 555

Query: 245 KTCE 248
           K C+
Sbjct: 556 KDCK 559



 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 76/259 (29%), Positives = 104/259 (40%), Gaps = 44/259 (16%)

Query: 2   PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
           P+GC    RC++  C+ C  G  G+      C + C  + G C  +G C C+ G++G  C
Sbjct: 409 PNGCSGHGRCVNGQCV-CDEGYTGEDCSQLRCPNDCH-SRGRCV-EGKCVCEQGFKGYDC 465

Query: 58  ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
                   C QHG C     C+C  G+ G+ C   +        C N G C+ DG     
Sbjct: 466 SDMSCPNDCHQHGRCVNG-MCVCDDGYTGEDCRDRQ----CPRDCSNRGLCV-DG----Q 515

Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
           CVC  GF G DC   + P     + C   G+C + Q       C C  GF+G  C+   +
Sbjct: 516 CVCEDGFTGPDCAELSCP-----NDCHGQGRCVNGQ-------CVCHEGFMGKDCK---E 560

Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
                 C     C+DG     C+C EGF G        DC    C        +     C
Sbjct: 561 QRCPSDCHGQGRCVDG----QCICHEGFTGL-------DCGQHSCPSDCNNLGQCVSGRC 609

Query: 237 LCPSGYGGKTCELVLPVPD 255
           +C  GY G+ C  V P  D
Sbjct: 610 ICNEGYSGEDCSEVSPPKD 628



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 67/238 (28%), Positives = 95/238 (39%), Gaps = 48/238 (20%)

Query: 15  CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ- 73
           C+  A G+      CS   + +   C     C C+PGW+G +C      P C  G CH  
Sbjct: 147 CLQPATGRLDTRPFCSGRGNFSTEGCG----CVCEPGWKGPNCSE----PECP-GNCHLR 197

Query: 74  ----PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
                 QCIC  G+ G+ C +        S C + G+C+        C+C  G+ G DC 
Sbjct: 198 GRCIDGQCICDDGFTGEDCSQ----LACPSDCNDQGKCV-----NGVCICFEGYAGADCS 248

Query: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
           R+  P             C ++ G  ++  C C  GF G  C  N   CL   C N   C
Sbjct: 249 REICPV-----------PCSEEHGTCVDGLCVCHDGFAGDDC--NKPLCL-NNCYNRGRC 294

Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
           ++      C+C EGF G       +DC+   C      R R  +  C C  G+ G+ C
Sbjct: 295 VEN----ECVCDEGFTG-------EDCSELICPNDCFDRGRCINGTCYCEEGFTGEDC 341



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 77/272 (28%), Positives = 106/272 (38%), Gaps = 56/272 (20%)

Query: 6   RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
           RC+   C+ C  G  G+      C + C    G C  +G+C C+ G+ G  C +    P 
Sbjct: 293 RCVENECV-CDEGFTGEDCSELICPNDC-FDRGRCI-NGTCYCEEGFTGEDCGK----PT 345

Query: 66  CQHGTCH-----QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
           C H  CH     +  QC+C  G+AG  C +        + C N G+C+ DG     C C 
Sbjct: 346 CPHA-CHTQGRCEEGQCVCDEGFAGVDCSEKR----CPADCHNRGRCV-DG----RCECD 395

Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF-------------------ALNFTCR 161
            GF G DC     P   +G      GQC  D+G+                    +   C 
Sbjct: 396 DGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCV 455

Query: 162 CLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPC 221
           C  GF G  C    D      C     C++G+    C+C +G+ G       +DC  R C
Sbjct: 456 CEQGFKGYDCS---DMSCPNDCHQHGRCVNGM----CVCDDGYTG-------EDCRDRQC 501

Query: 222 QRGARCRDRVHDFDCLCPSGYGGKTC-ELVLP 252
            R    R    D  C+C  G+ G  C EL  P
Sbjct: 502 PRDCSNRGLCVDGQCVCEDGFTGPDCAELSCP 533



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 57/177 (32%), Positives = 79/177 (44%), Gaps = 35/177 (19%)

Query: 77  CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
           C+C  GW G  C + E        C   G+C+ DG     C+C  GF G DC + A P  
Sbjct: 174 CVCEPGWKGPNCSEPE----CPGNCHLRGRCI-DG----QCICDDGFTGEDCSQLACP-- 222

Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
              S C + G+C       +N  C C  G+ GA C   +  C +       TC+DG+   
Sbjct: 223 ---SDCNDQGKC-------VNGVCICFEGYAGADCSREI--CPVPCSEEHGTCVDGL--- 267

Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC-ELVLP 252
            C+C +GFAG       DDC    C      R R  + +C+C  G+ G+ C EL+ P
Sbjct: 268 -CVCHDGFAG-------DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICP 316


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.143    0.517 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,973,929
Number of Sequences: 37866
Number of extensions: 1314710
Number of successful extensions: 11556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 5229
Number of HSP's gapped (non-prelim): 2402
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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