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Search of human proteins with 45545431
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 859 0.0
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 859 0.0
gi|110735443 delta-like 1 [Homo sapiens] 245 6e-65
gi|74136023 delta-like 1 homolog [Homo sapiens] 241 8e-64
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 240 2e-63
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 227 2e-59
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 227 2e-59
gi|4557679 jagged 1 precursor [Homo sapiens] 225 6e-59
gi|24041035 notch 2 preproprotein [Homo sapiens] 206 4e-53
gi|148833508 notch1 preproprotein [Homo sapiens] 194 1e-49
gi|134244285 Notch homolog 3 [Homo sapiens] 186 4e-47
gi|148886654 polydom [Homo sapiens] 185 5e-47
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 184 9e-47
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 177 1e-44
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 177 1e-44
gi|112420992 crumbs homolog 2 [Homo sapiens] 169 5e-42
gi|55770876 notch4 preproprotein [Homo sapiens] 164 1e-40
gi|4759146 slit homolog 2 [Homo sapiens] 152 6e-37
gi|188528675 slit homolog 1 [Homo sapiens] 150 2e-36
gi|122937283 6720455I24Rik homolog [Homo sapiens] 149 3e-36
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 147 2e-35
gi|11321571 slit homolog 3 [Homo sapiens] 138 7e-33
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 135 8e-32
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 126 4e-29
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 125 8e-29
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 121 9e-28
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 121 1e-27
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 114 1e-25
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens] 107 1e-23
gi|153946395 tenascin C precursor [Homo sapiens] 103 3e-22
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 859 bits (2219), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
Sbjct: 1 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
Query: 61 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL
Sbjct: 61 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
Sbjct: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
Query: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA
Sbjct: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
Query: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV
Sbjct: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
Query: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
SMLPAGLPLPRDLPPEPGKTTAL
Sbjct: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 859 bits (2219), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC
Sbjct: 1 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 60
Query: 61 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL
Sbjct: 61 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM
Sbjct: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
Query: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA
Sbjct: 241 GYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEA 300
Query: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV
Sbjct: 301 GLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQV 360
Query: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
SMLPAGLPLPRDLPPEPGKTTAL
Sbjct: 361 SMLPAGLPLPRDLPPEPGKTTAL 383
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 245 bits (625), Expect = 6e-65
Identities = 119/321 (37%), Positives = 145/321 (45%), Gaps = 73/321 (22%)
Query: 14 LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ 73
+C G G C CD HG C G C+C GW+G +C+ C+R PGC HGTC Q
Sbjct: 211 VCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQ 270
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCER--- 130
PWQC C GW G FC++D + CT PC+NG C G G Y C C PG+ G CE
Sbjct: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330
Query: 131 --KAGPCEQAGS-------------------------------PCRNGGQCQD--DQGFA 155
PC+ GS PC NGG+C D D G++
Sbjct: 331 ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390
Query: 156 LN----------------------------------FTCRCLVGFVGARCEVNVDDCLMR 181
+ CRC GF G C+ NVDDC
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450
Query: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
PCANG TC DG+N FSC CP G+ GR C+ + C PC GA C +R H + C C G
Sbjct: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510
Query: 242 YGGKTCELVLP-VPDPPTTVD 261
YGG C+ +LP +P P VD
Sbjct: 511 YGGPNCQFLLPELPPGPAVVD 531
Score = 218 bits (554), Expect = 9e-57
Identities = 107/295 (36%), Positives = 132/295 (44%), Gaps = 76/295 (25%)
Query: 27 DDCSSHCD-----LAHGCCAPDGSCRCDPGWE---------------------------- 53
+ CS C H C G C+PGW+
Sbjct: 186 EGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKC 245
Query: 54 -----GLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM 108
G +C+ C+R PGC HGTC QPWQC C GW G FC++D + CT PC+NG C
Sbjct: 246 RVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
Query: 109 YDGGGEYHCVCLPGFHGRDCER-----KAGPCEQAGS----------------------- 140
G G Y C C PG+ G CE PC+ GS
Sbjct: 306 NTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICEL 365
Query: 141 --------PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
PC NGG+C D ++CRC VG+ G CE +D C PC+NGA C+D
Sbjct: 366 SAMTCADGPCFNGGRCSDSPDG--GYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL 423
Query: 193 INRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
+ + C C GF+GR C N+DDCAS PC G CRD V+DF C CP GY G+ C
Sbjct: 424 GDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 241 bits (615), Expect = 8e-64
Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)
Query: 10 LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69
L+ +L +L A G +C C+ +G C D CRC PGW+G C++CV PGC HG
Sbjct: 7 LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66
Query: 70 TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
C +P QCIC GW G+ CD+D C++ +PC N G C+ G Y C C PG+ G+DC+
Sbjct: 67 LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
Query: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
+K GPC GSPC++GG C DD+G A + +C C GF G CE+ + C PC N C
Sbjct: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
D F C CP GF + C+ + +CAS PCQ G C ++CLC + G TC
Sbjct: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244
Query: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306
+ P P G A + P P +L++S+KE+ ++ L E
Sbjct: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303
Query: 307 LVALVVFGALTAALVLATV 325
+ + G LT+ +VL TV
Sbjct: 304 AICFTILGVLTSLVVLGTV 322
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 240 bits (612), Expect = 2e-63
Identities = 97/235 (41%), Positives = 136/235 (57%), Gaps = 6/235 (2%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
Query: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
F C+CPE + G C ++++DC + CQ G C+D V+ + C+CP G+GG+ CEL
Sbjct: 406 GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
Score = 171 bits (433), Expect = 1e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 660 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 717
Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 718 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 772
Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
Score = 170 bits (430), Expect = 2e-42
Identities = 91/253 (35%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 27 DDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PW 75
+DC C HG D C C G+ G HCE C P G C +
Sbjct: 425 NDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482
Query: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C PC
Sbjct: 483 HCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPC 540
Query: 136 EQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARCEVN 174
G CR C D G + NF+C C GF G C N
Sbjct: 541 P--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598
Query: 175 VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V+DF
Sbjct: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 658
Query: 235 DCLCPSGYGGKTC 247
C C G+ GKTC
Sbjct: 659 YCACDDGWKGKTC 671
Score = 147 bits (370), Expect = 2e-35
Identities = 96/292 (32%), Positives = 116/292 (39%), Gaps = 80/292 (27%)
Query: 29 CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
C+S+ G C P G C C GW G C + C P GTC ++CI
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
Query: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
C W G C D + C Q CQ+GG C D Y CVC GF GR CE + C A
Sbjct: 411 CPEQWVGATCQLDVNDCRGQ--CQHGGTCK-DLVNGYQCVCPRGFGGRHCELERDEC--A 465
Query: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL------------------- 179
SPC +GG C+D A F C C GF G CEV+VD C
Sbjct: 466 SSPCHSGGLCED---LADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 522
Query: 180 --------------MRPCANGA-----------------TCLDGI------------NRF 196
PC GA T G+ F
Sbjct: 523 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582
Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
SC+C GF G +C N+DDC +PC+ G C D V F C CPSG+ G+ C+
Sbjct: 583 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
Score = 66.6 bits (161), Expect = 4e-11
Identities = 68/275 (24%), Positives = 88/275 (32%), Gaps = 68/275 (24%)
Query: 25 RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHC-----ERCVRMPGCQHGTC---HQ 73
R C ++ G C G C C PGW+G C C+ P GTC
Sbjct: 674 REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA 733
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM------------------------- 108
+ CIC GW G+ C + + C PC NGG C+
Sbjct: 734 SFSCICRDGWEGRTCTHNTNDCNPL-PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 792
Query: 109 ------------YDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRNGGQCQDDQG 153
D Y C C PG G C+ G C G+P +G +D
Sbjct: 793 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN 852
Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
+CRCL G R + + C +PC S CP G R
Sbjct: 853 -----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG--QRCLEKAP 897
Query: 214 DDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
C PC+ C + CL SG+ C
Sbjct: 898 GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 227 bits (578), Expect = 2e-59
Identities = 104/283 (36%), Positives = 134/283 (47%), Gaps = 44/283 (15%)
Query: 9 HLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
H VC L C+ G G+ + C S C +G C+ C C PGW+G C C+
Sbjct: 197 HYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPH 256
Query: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
GC+HGTC PWQC C GW G FCD+D + CT SPC+NG C G Y C C PG+
Sbjct: 257 NGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGY 316
Query: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQ---------GF-------------------- 154
G DCE + C+ +PCRNGG C+D + G+
Sbjct: 317 TGVDCELELSECDS--NPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNG 374
Query: 155 --------ALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
N+ C C F G+ CE VD C PCANG CL+ C C GF G
Sbjct: 375 GSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTG 434
Query: 207 RFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
+C +++ DCA PC G C D + C CP+G+ G+ CE+
Sbjct: 435 TYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEV 477
Score = 85.9 bits (211), Expect = 6e-17
Identities = 64/197 (32%), Positives = 76/197 (38%), Gaps = 51/197 (25%)
Query: 28 DCSSHCDLAHGCCAP--DG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQPWQ---- 76
+C S+ G C DG C C PG+ GLHCE C P G+C + Q
Sbjct: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANY 386
Query: 77 -CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG------------------------ 111
C C + G C+K CT+ +PC NGGQC+ G
Sbjct: 387 ACECPPNFTGSNCEKKVDRCTS-NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCA 445
Query: 112 ------GGEYH-------CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
GG H C C GF GR CE + A SPC N C D F
Sbjct: 446 RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS-TDTF 504
Query: 159 TCRCLVGFVGARCEVNV 175
C C GFVG+RCE V
Sbjct: 505 VCNCPYGFVGSRCEFPV 521
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 227 bits (578), Expect = 2e-59
Identities = 97/272 (35%), Positives = 136/272 (50%), Gaps = 42/272 (15%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
Query: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRP---------------------------------- 220
F C+CPE + G C ++ ++C +P
Sbjct: 406 GFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC 465
Query: 221 ---CQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
CQ G C+D V+ + C+CP G+GG+ CEL
Sbjct: 466 RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL 497
Score = 171 bits (433), Expect = 1e-42
Identities = 91/256 (35%), Positives = 117/256 (45%), Gaps = 38/256 (14%)
Query: 24 VRADDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ-- 73
+ +DC C HG D C C G+ G HCE C P G C
Sbjct: 460 INVNDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 517
Query: 74 -PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
+ C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C
Sbjct: 518 DGFHCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPR 575
Query: 133 GPCEQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARC 171
PC G CR C D G + NF+C C GF G C
Sbjct: 576 EPCP--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633
Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV 231
N+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V
Sbjct: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693
Query: 232 HDFDCLCPSGYGGKTC 247
+DF C C G+ GKTC
Sbjct: 694 NDFYCACDDGWKGKTC 709
Score = 171 bits (433), Expect = 1e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 698 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 755
Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 756 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 810
Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 811 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
Score = 159 bits (401), Expect = 5e-39
Identities = 88/258 (34%), Positives = 119/258 (46%), Gaps = 19/258 (7%)
Query: 29 CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
C+S+ G C P G C C GW G C + C P GTC ++CI
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
Query: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
C W G C D + C + PC N C GG Y+C C+PG+ G +C C
Sbjct: 411 CPEQWVGATCQLDANECEGK-PCLNAFSCKNLIGG-YYCDCIPGWKGINCHINVNDCR-- 466
Query: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
C++GG C+D + C C GF G CE+ D+C PC +G C D + F C
Sbjct: 467 -GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHC 522
Query: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPDPP 257
CP+GF+G C +++D C PC+ GARC + D+ C CP +GGK C + P P
Sbjct: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582
Query: 258 TTVDTPLGPTSAVVVPAT 275
V G + +P T
Sbjct: 583 CRVIDGCGSDAGPGMPGT 600
Score = 147 bits (372), Expect = 1e-35
Identities = 83/233 (35%), Positives = 113/233 (48%), Gaps = 37/233 (15%)
Query: 46 CRCDPGWEGLHCERCVR--MPGCQHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
C C PGW+G++C V CQHG TC +QC+C G+ G+ C+ + C + S
Sbjct: 447 CDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-S 505
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
PC +GG C D +HC C GF G CE CE SPCRNG +C + +G ++
Sbjct: 506 PCHSGGLCE-DLADGFHCHCPQGFSGPLCEVDVDLCEP--SPCRNGARCYNLEG---DYY 559
Query: 160 CRCLVGFVGARCEVNVDDC------LMRPCANGA------TCLDGI------------NR 195
C C F G C V + C ++ C + A T G+
Sbjct: 560 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 619
Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
FSC+C GF G +C N+DDC +PC+ G C D V F C CPSG+ G+ C+
Sbjct: 620 FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 672
Score = 66.6 bits (161), Expect = 4e-11
Identities = 68/275 (24%), Positives = 88/275 (32%), Gaps = 68/275 (24%)
Query: 25 RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHC-----ERCVRMPGCQHGTC---HQ 73
R C ++ G C G C C PGW+G C C+ P GTC
Sbjct: 712 REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA 771
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM------------------------- 108
+ CIC GW G+ C + + C PC NGG C+
Sbjct: 772 SFSCICRDGWEGRTCTHNTNDCNPL-PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 830
Query: 109 ------------YDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRNGGQCQDDQG 153
D Y C C PG G C+ G C G+P +G +D
Sbjct: 831 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN 890
Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
+CRCL G R + + C +PC S CP G R
Sbjct: 891 -----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG--QRCLEKAP 935
Query: 214 DDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
C PC+ C + CL SG+ C
Sbjct: 936 GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 225 bits (573), Expect = 6e-59
Identities = 89/235 (37%), Positives = 129/235 (54%), Gaps = 5/235 (2%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
C+ G G C C HG C G CRC GW+GL+C++C+ PGC HG C++P
Sbjct: 220 CMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEP 279
Query: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
WQC+C + W G+ CDKD + C T PC NGG C G +Y C C G+ G +CE
Sbjct: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHA 339
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C PC N G C++ +L F C C G+ G C N+DDC C++G TC D +N
Sbjct: 340 C--LSDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN 394
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
F C+CP + G+ C ++ ++C ++PC C++ + + C C G+ G+ C++
Sbjct: 395 GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDI 449
Score = 182 bits (463), Expect = 3e-46
Identities = 96/274 (35%), Positives = 130/274 (47%), Gaps = 50/274 (18%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CV 61
C+ G GQ +C + + G C D SCR C PG+ G HCER C
Sbjct: 438 CLPGWMGQ-----NCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
Query: 62 RMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCV 118
P G C +QC+C +G++G C D C +PCQNG QC Y+ +Y C
Sbjct: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEP-NPCQNGAQC-YNRASDYFCK 550
Query: 119 CLPGFHGRDCER-----KAGPCEQAGS--------------------PCRNGGQCQDDQG 153
C + G++C + PCE S C G+C+ G
Sbjct: 551 CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSG 610
Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL 213
FTC C GF G C N++DC PC NG TC+DG+N + C+C +G+ G +C N+
Sbjct: 611 G--KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNI 668
Query: 214 DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
+DC+ PC G CRD V+DF C C +G+ GKTC
Sbjct: 669 NDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTC 702
Score = 169 bits (428), Expect = 4e-42
Identities = 90/236 (38%), Positives = 119/236 (50%), Gaps = 20/236 (8%)
Query: 27 DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PW 75
+DC S+ G C DG C C GWEG +CE C + P GTC +
Sbjct: 631 NDCESNPCRNGGTCI-DGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689
Query: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGP 134
C C +GW GK C + C ++ C NGG C YD G + C+C G+ G C +
Sbjct: 690 YCDCKNGWKGKTCHSRDSQCD-EATCNNGGTC-YDEGDAFKCMCPGGWEGTTCNIARNSS 747
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C +PC NGG C + +FTC C G+ G C N +DC PC N TC+DG N
Sbjct: 748 C--LPNPCHNGGTCVVN---GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
+ C C GFAG C IN+++C S PC GA C D ++ + C+CP G+ G C+ V
Sbjct: 803 WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV 858
Score = 131 bits (330), Expect = 9e-31
Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 41/237 (17%)
Query: 46 CRCDPGWEGLHCERCVR--MPGCQH-GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQS 99
C C PGW G +C+ + + CQ+ +C ++CIC G+AG C++D C + +
Sbjct: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS-N 494
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
PC NGG C + + C+C GF G C+ CE +PC+NG QC + A ++
Sbjct: 495 PCLNGGHCQNEIN-RFQCLCPTGFSGNLCQLDIDYCEP--NPCQNGAQCYNR---ASDYF 548
Query: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCL---------DGIN---------------- 194
C+C + G C D C PC +C +G+
Sbjct: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ 608
Query: 195 ---RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
+F+C C +GF G +C N++DC S PC+ G C D V+ + C+C G+ G CE
Sbjct: 609 SGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCE 665
Score = 81.3 bits (199), Expect = 1e-15
Identities = 66/203 (32%), Positives = 88/203 (43%), Gaps = 34/203 (16%)
Query: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
G C +G +C C GWEG C + C P GTC ++C C G+AG
Sbjct: 757 GTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816
Query: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG-PCEQAGSPCRNGG 146
C + + C + SPC G C+ + G Y CVC PG G C+ +G PC GS +G
Sbjct: 817 CRININECQS-SPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGA 874
Query: 147 QCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAG 206
+ DD TC+CL G R + C RPC +++ CP +G
Sbjct: 875 KWDDDCN-----TCQCLNG----RIACSKVWCGPRPCL--------LHKGHSECP---SG 914
Query: 207 RFCTINLDD-CASRPCQRGARCR 228
+ C LDD C PC CR
Sbjct: 915 QSCIPILDDQCFVHPCTGVGECR 937
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 206 bits (523), Expect = 4e-53
Identities = 99/251 (39%), Positives = 133/251 (52%), Gaps = 18/251 (7%)
Query: 12 CLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRM 63
C+L G Q V A + C+ A C +C C PGW+G C + C+
Sbjct: 821 CVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISK 880
Query: 64 PGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
P HG CH + C C G++G C++D C +PCQNGG CM DG + C+CL
Sbjct: 881 PCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLA-NPCQNGGSCM-DGVNTFSCLCL 938
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
PGF G C+ C PC+NGG C D + ++TC+C GF G CE N+++C
Sbjct: 939 PGFTGDKCQTDMNEC--LSEPCKNGGTCSD---YVNSYTCKCQAGFDGVHCENNINECTE 993
Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
C NG TC+DGIN FSCLCP GF G FC +++C+S PC C D + + C CP
Sbjct: 994 SSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPL 1053
Query: 241 GYGGKTCELVL 251
GY GK C+ ++
Sbjct: 1054 GYTGKNCQTLV 1064
Score = 180 bits (456), Expect = 2e-45
Identities = 94/263 (35%), Positives = 128/263 (48%), Gaps = 31/263 (11%)
Query: 14 LCILGAPGQPVRADDCSSHCD-LAHGCCAPDG---------SCRCDPGWEGLHC---ERC 60
+C+ G G DDCS + D A C P SC C G GL C + C
Sbjct: 325 VCVNGWSG-----DDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDAC 379
Query: 61 VRMPG-----CQHGTCHQPWQCICHSGWAGKFC--DKDEHICTTQSPCQNGGQCMYDGGG 113
+ P C + + C C G+ G C D DE +PC++ G+C+ + G
Sbjct: 380 ISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV-NTDG 438
Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
+HC CL G+ G CE C PC+N C D G FTC C+ GF G CE+
Sbjct: 439 AFHCECLKGYAGPRCEMDINECHS--DPCQNDATCLDKIG---GFTCLCMPGFKGVHCEL 493
Query: 174 NVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD 233
+++C PC N C+D +NRF CLCP GF G C I++DDC+S PC GA+C D +
Sbjct: 494 EINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNG 553
Query: 234 FDCLCPSGYGGKTCELVLPVPDP 256
++C C +G+ G CE + DP
Sbjct: 554 YECQCATGFTGVLCEENIDNCDP 576
Score = 177 bits (450), Expect = 1e-44
Identities = 96/258 (37%), Positives = 128/258 (49%), Gaps = 30/258 (11%)
Query: 14 LCILGAPGQPV--RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRM 63
LC +G G ++CSSH L G C DG C C G+ G +C+ C R
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCV-DGLGTYRCSCPLGYTGKNCQTLVNLCSRS 1070
Query: 64 PGCQHGTCHQPW---QCICHSGWAGKFCDKDEHICTTQSP---------CQNGGQCMYDG 111
P GTC Q QC+C SGWAG +CD C + CQ+ G C+ +
Sbjct: 1071 PCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCI-NA 1129
Query: 112 GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
G ++C C G+ G CE + C A +PC++G C D F + C C+ G+ G C
Sbjct: 1130 GNTHYCQCPLGYTGSYCEEQLDEC--ASNPCQHGATCSD---FIGGYRCECVPGYQGVNC 1184
Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP-CQRGARCRDR 230
E VD+C +PC NG TC+D +N F C CP G G C N+DDCA P C G +C DR
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDR 1244
Query: 231 VHDFDCLCPSGYGGKTCE 248
+ + C C G+ G+ CE
Sbjct: 1245 IGGYSCRCLPGFAGERCE 1262
Score = 171 bits (433), Expect = 1e-42
Identities = 97/249 (38%), Positives = 126/249 (50%), Gaps = 20/249 (8%)
Query: 15 CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
C +G G+ + D C SH C C A SC+C G+ G CE V +PG C
Sbjct: 133 CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 192
Query: 67 QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
QHG TC +QC C G+ G++CD ++ SPC NGG C G + C CLPG
Sbjct: 193 QHGGTCLNLPGSYQCQCPQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLPG 251
Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
F G CER C C+NGG C D + CRC + G C +VD+CL++P
Sbjct: 252 FEGSTCERNIDDCPN--HRCQNGGVCVDGVN---TYNCRCPPQWTGQFCTEDVDECLLQP 306
Query: 183 --CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
C NG TC + + C+C G++G C+ N+DDCA C G+ C DRV F C+CP
Sbjct: 307 NACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPE 366
Query: 241 GYGGKTCEL 249
G G C L
Sbjct: 367 GKAGLLCHL 375
Score = 166 bits (421), Expect = 2e-41
Identities = 80/210 (38%), Positives = 112/210 (53%), Gaps = 13/210 (6%)
Query: 46 CRCDPGWEGLHCE---RCVRMPGCQHGTCH---QPWQCICHSGWAGKFCDKDEHICTTQS 99
C C G+ G C+ C+ P TC + C C +G+ G+ C+ D + C
Sbjct: 131 CTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPG 190
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
CQ+GG C+ + G Y C C GF G+ C+ PC A SPC NGG C+ F F
Sbjct: 191 HCQHGGTCL-NLPGSYQCQCPQGFTGQYCDSLYVPC--APSPCVNGGTCRQTGDFT--FE 245
Query: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASR 219
C CL GF G+ CE N+DDC C NG C+DG+N ++C CP + G+FCT ++D+C +
Sbjct: 246 CNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQ 305
Query: 220 P--CQRGARCRDRVHDFDCLCPSGYGGKTC 247
P CQ G C +R + C+C +G+ G C
Sbjct: 306 PNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Score = 161 bits (407), Expect = 1e-39
Identities = 88/249 (35%), Positives = 118/249 (47%), Gaps = 22/249 (8%)
Query: 15 CILGAPGQPVRAD----DCSSHCDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMP 64
C+ G GQ D D HC C GS C+C G+ G +C+ C P
Sbjct: 170 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSP 229
Query: 65 GCQHGTCHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
GTC Q ++C C G+ G C+++ C CQNGG C+ DG Y+C C
Sbjct: 230 CVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR-CQNGGVCV-DGVNTYNCRCP 287
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
P + G+ C C + C+NGG C + G + C C+ G+ G C N+DDC
Sbjct: 288 PQWTGQFCTEDVDECLLQPNACQNGGTCANRNG---GYGCVCVNGWSGDDCSENIDDCAF 344
Query: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV--HDFDCLC 238
C G+TC+D + FSC+CPEG AG C ++ D C S PC +GA C + C C
Sbjct: 345 ASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD-DACISNPCHKGALCDTNPLNGQYICTC 403
Query: 239 PSGYGGKTC 247
P GY G C
Sbjct: 404 PQGYKGADC 412
Score = 157 bits (398), Expect = 1e-38
Identities = 87/247 (35%), Positives = 120/247 (48%), Gaps = 21/247 (8%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHG---CCAPDG--SCRCDPGWEGLHCE----RCVRMPG 65
C+ G G D H D C G +C C PG++G+HCE C P
Sbjct: 444 CLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPC 503
Query: 66 CQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
+G C +QC+C G+ G C D C++ +PC NG +C+ G Y C C G
Sbjct: 504 VNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS-TPCLNGAKCIDHPNG-YECQCATG 561
Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
F G CE C+ PC +G QCQD ++TC C G++GA C +D+C P
Sbjct: 562 FTGVLCEENIDNCDP--DPCHHG-QCQDGID---SYTCICNPGYMGAICSDQIDECYSSP 615
Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
C N C+D +N + C C G +G C IN DDCAS PC G C D ++ + C+C G+
Sbjct: 616 CLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGI-CMDGINRYSCVCSPGF 674
Query: 243 GGKTCEL 249
G+ C +
Sbjct: 675 TGQRCNI 681
Score = 156 bits (395), Expect = 3e-38
Identities = 79/212 (37%), Positives = 108/212 (50%), Gaps = 18/212 (8%)
Query: 46 CRCDPGWEGLHC----ERCVRMPG--CQH-GTCHQP---WQCICHSGWAGKFCDKDEHIC 95
C C G++G C + C C+H G C + C C G+AG C+ D + C
Sbjct: 401 CTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINEC 460
Query: 96 TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFA 155
+ PCQN C+ GG + C+C+PGF G CE + C+ +PC N GQC D
Sbjct: 461 HSD-PCQNDATCLDKIGG-FTCLCMPGFKGVHCELEINECQS--NPCVNNGQCVDKVN-- 514
Query: 156 LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
F C C GF G C++++DDC PC NGA C+D N + C C GF G C N+D+
Sbjct: 515 -RFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN 573
Query: 216 CASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
C PC G +C+D + + C+C GY G C
Sbjct: 574 CDPDPCHHG-QCQDGIDSYTCICNPGYMGAIC 604
Score = 152 bits (385), Expect = 4e-37
Identities = 83/240 (34%), Positives = 116/240 (48%), Gaps = 19/240 (7%)
Query: 27 DDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQ 76
D+C S L G C C C PG G++CE C P C HG C +
Sbjct: 609 DECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP-CIHGICMDGINRYS 667
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
C+C G+ G+ C+ D C + +PC+ G C+ +G + C+C G H C + C
Sbjct: 668 CVCSPGFTGQRCNIDIDECAS-NPCRKGATCI-NGVNGFRCICPEGPHHPSCYSQVNEC- 724
Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
+PC +G C G + C C G+VG CEV+ ++CL PC NG TC + +N +
Sbjct: 725 -LSNPCIHGN-CT---GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGY 779
Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
C C +GF G C +N+D+CAS PC C D + + C C Y GK C+ VL P
Sbjct: 780 RCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSP 839
Score = 150 bits (378), Expect = 2e-36
Identities = 88/292 (30%), Positives = 127/292 (43%), Gaps = 61/292 (20%)
Query: 14 LCILGAPGQPVRAD--DCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCER----CVRMP 64
LC+ G G + D +C S G C+ +C+C G++G+HCE C
Sbjct: 936 LCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESS 995
Query: 65 GCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
GTC + C+C G+ G FC + + C++ PC N G C+ DG G Y C C
Sbjct: 996 CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSH-PCLNEGTCV-DGLGTYRCSCPL 1053
Query: 122 GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQ----------------------------- 152
G+ G++C+ C + SPC+N G C +
Sbjct: 1054 GYTGKNCQTLVNLCSR--SPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASR 1111
Query: 153 ------------GFALN----FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
G +N C+C +G+ G+ CE +D+C PC +GATC D I +
Sbjct: 1112 RGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGY 1171
Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C C G+ G C +D+C ++PCQ G C D V+ F C CP G G CE
Sbjct: 1172 RCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Score = 142 bits (357), Expect = 7e-34
Identities = 84/257 (32%), Positives = 114/257 (44%), Gaps = 28/257 (10%)
Query: 10 LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAP----DGSCRCDPGWEGLHCERCVRMPG 65
L+ L AP ++ D C + G C G C+C G+ G +C+ R P
Sbjct: 12 LLALWLCCAAPAHALQCRDGYEPC-VNEGMCVTYHNGTGYCKCPEGFLGEYCQH--RDP- 67
Query: 66 CQHGTCHQPWQCI-----------CHSGWAGKFCD-KDEHICTTQSPCQNGGQCMYDGGG 113
C+ C C+ C SG+ G+ C H C PC NGG C
Sbjct: 68 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD 127
Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
Y C C GF G++C+ C PC NG C A F+C+CL GF G +CE
Sbjct: 128 TYECTCQVGFTGKECQ-WTDAC--LSHPCANGSTCTT---VANQFSCKCLTGFTGQKCET 181
Query: 174 NVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDR-V 231
+V++C + C +G TCL+ + C CP+GF G++C CA PC G CR
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGD 241
Query: 232 HDFDCLCPSGYGGKTCE 248
F+C C G+ G TCE
Sbjct: 242 FTFECNCLPGFEGSTCE 258
Score = 122 bits (306), Expect = 5e-28
Identities = 93/301 (30%), Positives = 113/301 (37%), Gaps = 69/301 (22%)
Query: 15 CILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMP 64
C LG G + D+C+S+ HG D C C PG++G++CE C P
Sbjct: 1137 CPLGYTGSYCEEQLDECASN-PCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQP 1195
Query: 65 GCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
GTC ++C C G G C+++ C C NGGQCM D G Y C CLP
Sbjct: 1196 CQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCM-DRIGGYSCRCLP 1254
Query: 122 GFH----------------------------------------GRDCERKAGPCEQAGSP 141
GF GR CE C Q P
Sbjct: 1255 GFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQ--MP 1312
Query: 142 CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCP 201
C NGG C F CRC GF GARC+ C C G C+ + C CP
Sbjct: 1313 CLNGGTCAVASNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCP 1369
Query: 202 EGFAGRFCTINLDDCASRPCQRGARCRDRVHD--FDCLCPSGYGGKTCEL-VLPVPDPPT 258
+ R C CAS PCQ G C + + C C + G CEL P PP
Sbjct: 1370 ---SPRDCE---SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPA 1423
Query: 259 T 259
T
Sbjct: 1424 T 1424
Score = 62.0 bits (149), Expect = 9e-10
Identities = 61/233 (26%), Positives = 85/233 (36%), Gaps = 23/233 (9%)
Query: 27 DDCSSHCDLAHGCCA-----PDGS-CRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICH 80
D C L G CA PDG CRC PG+ G C+ C C + QC+
Sbjct: 1306 DVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQS-----SCGQVKCRKGEQCVHT 1360
Query: 81 SGWAGKFCD--KDEHICTTQSPCQNGGQCMYDGGGEYH-CVCLPGFHGRDCERKAGPCEQ 137
+ FC +D SPCQ+GG C Y+ C C P F G CE P
Sbjct: 1361 ASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPST 1420
Query: 138 AGSPCRNGGQCQDDQGFALNFTCRC-LVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
+ C + + + C + G C + +++ C++ C D IN
Sbjct: 1421 PPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWAN-CSSPLPCWDYINN- 1478
Query: 197 SCLCPEGFAGRFCTINLDDCA--SRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
C E C + +C S+ C+ C D H D C G + C
Sbjct: 1479 --QCDELCNTVECLFDNFECQGNSKTCKYDKYCAD--HFKDNHCDQGCNSEEC 1527
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 194 bits (493), Expect = 1e-49
Identities = 101/249 (40%), Positives = 126/249 (50%), Gaps = 20/249 (8%)
Query: 12 CLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRM 63
CLL GA + V A S C C + SC C GW+G CE CV
Sbjct: 817 CLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLS 876
Query: 64 PGCQHGTC----HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC 119
P C+HG H ++C C +G++G+ C+ D C +PC NGG C DG C C
Sbjct: 877 P-CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRP-NPCHNGGSCT-DGINTAFCDC 933
Query: 120 LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL 179
LPGF G CE C A PCRNG C D ++TC C GF G CE N DC
Sbjct: 934 LPGFRGTFCEEDINEC--ASDPCRNGANCTDCVD---SYTCTCPAGFSGIHCENNTPDCT 988
Query: 180 MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCP 239
C NG TC+DGIN F+CLCP GF G +C ++++C S+PC G C+D + C CP
Sbjct: 989 ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP 1048
Query: 240 SGYGGKTCE 248
GY G C+
Sbjct: 1049 QGYTGPNCQ 1057
Score = 178 bits (452), Expect = 6e-45
Identities = 93/286 (32%), Positives = 134/286 (46%), Gaps = 56/286 (19%)
Query: 15 CILGAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMP 64
C+ G GQ DDC + G C DG +CRC P W G +C + C MP
Sbjct: 245 CLPGFTGQNCEENIDDCPGNNCKNGGACV-DGVNTYNCRCPPEWTGQYCTEDVDECQLMP 303
Query: 65 G-CQHG-TCHQP---WQCICHSGWAGKFCDKDEHICTT---------------------- 97
CQ+G TCH + C+C +GW G+ C ++ C +
Sbjct: 304 NACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPH 363
Query: 98 --------------QSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKAGPCEQAGSPC 142
+PC G C + G+ C C G+ G C + C +PC
Sbjct: 364 GRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423
Query: 143 RNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE 202
+ G+C + G +F C+CL G+ G RCE++V++C+ PC N ATCLD I F C+C
Sbjct: 424 EHAGKCINTLG---SFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP 480
Query: 203 GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
G+ G C +N D+CAS PC RC D++++F C CP+G+ G C+
Sbjct: 481 GYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQ 526
Score = 172 bits (437), Expect = 3e-43
Identities = 92/239 (38%), Positives = 124/239 (51%), Gaps = 20/239 (8%)
Query: 25 RADDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPG-CQHG-TCHQP- 74
+AD C+S+ G C P + C C P + G C + C + PG C+HG TCH
Sbjct: 140 QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV 199
Query: 75 --WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
++C+C + G C++ C+ SPCQNGG C G + C CLPGF G++CE
Sbjct: 200 GSYRCVCRATHTGPNCERPYVPCSP-SPCQNGGTCRPTGDVTHECACLPGFTGQNCEENI 258
Query: 133 GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP--CANGATCL 190
C G+ C+NGG C D + CRC + G C +VD+C + P C NG TC
Sbjct: 259 DDCP--GNNCKNGGACVDGVN---TYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCH 313
Query: 191 DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
+ ++C+C G+ G C+ N+DDCAS C GA C DRV F C CP G G C L
Sbjct: 314 NTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHL 372
Score = 171 bits (434), Expect = 8e-43
Identities = 91/258 (35%), Positives = 125/258 (48%), Gaps = 22/258 (8%)
Query: 14 LCILGAPGQPV--RADDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHC---ERCVRMP 64
+C+ G G+ DDC+S HG D C C G GL C + C+ P
Sbjct: 322 VCVNGWTGEDCSENIDDCASAACF-HGATCHDRVASFYCECPHGRTGLLCHLNDACISNP 380
Query: 65 -----GCQHGTCHQPWQCICHSGWAGKFCDKDEHICTT-QSPCQNGGQCMYDGGGEYHCV 118
C + C C SG+ G C +D C+ +PC++ G+C+ + G + C
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCI-NTLGSFECQ 439
Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
CL G+ G CE C +PC+N C D G F C C+ G+ G CEVN D+C
Sbjct: 440 CLQGYTGPRCEIDVNEC--VSNPCQNDATCLDQIG---EFQCICMPGYEGVHCEVNTDEC 494
Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
PC + CLD IN F C CP GF G C ++D+CAS PC+ GA+C D + + C+C
Sbjct: 495 ASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVC 554
Query: 239 PSGYGGKTCELVLPVPDP 256
GY G CE+ + DP
Sbjct: 555 TEGYTGTHCEVDIDECDP 572
Score = 171 bits (433), Expect = 1e-42
Identities = 92/247 (37%), Positives = 122/247 (49%), Gaps = 21/247 (8%)
Query: 15 CILGAPGQPVRAD--DCSSH-CDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPG 65
C+ G G D +C S+ C C G C C PG+EG+HCE C P
Sbjct: 440 CLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPC 499
Query: 66 CQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
+G C +QC C +G+ G C D C + +PC+NG +C+ DG Y CVC G
Sbjct: 500 LHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAS-TPCKNGAKCL-DGPNTYTCVCTEG 557
Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
+ G CE C+ PC G C+D FTC C G+ G CE N+++C +P
Sbjct: 558 YTGTHCEVDIDECDP--DPCHYGS-CKDG---VATFTCLCRPGYTGHHCETNINECSSQP 611
Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
C +G TC D N + C C +G G C INLDDCAS PC G C D++ ++C C GY
Sbjct: 612 CRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGY 670
Query: 243 GGKTCEL 249
G C +
Sbjct: 671 TGSMCNI 677
Score = 166 bits (421), Expect = 2e-41
Identities = 95/259 (36%), Positives = 128/259 (49%), Gaps = 31/259 (11%)
Query: 5 CRCLH-LVCLLCILGAPGQPVRADDCSSH-CDLAHGCCAPDGS----CRCDPGWEGLHCE 58
C C H LLC L D C S+ C+ C + C C G+ G C
Sbjct: 359 CECPHGRTGLLCHLN--------DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACS 410
Query: 59 RCVRMPG-----CQH-GTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMY 109
+ V C+H G C ++C C G+ G C+ D + C + +PCQN C+
Sbjct: 411 QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVS-NPCQNDATCL- 468
Query: 110 DGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGA 169
D GE+ C+C+PG+ G CE C A SPC + G+C D F C C GF G
Sbjct: 469 DQIGEFQCICMPGYEGVHCEVNTDEC--ASSPCLHNGRCLDKIN---EFQCECPTGFTGH 523
Query: 170 RCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
C+ +VD+C PC NGA CLDG N ++C+C EG+ G C +++D+C PC G+ C+D
Sbjct: 524 LCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS-CKD 582
Query: 230 RVHDFDCLCPSGYGGKTCE 248
V F CLC GY G CE
Sbjct: 583 GVATFTCLCRPGYTGHHCE 601
Score = 163 bits (413), Expect = 2e-40
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 20/237 (8%)
Query: 27 DDCS---SHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPGCQHGTCHQP--- 74
D+CS + C+ A C GS C+C G+ G CE CV P TC
Sbjct: 414 DECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGE 473
Query: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
+QCIC G+ G C+ + C + SPC + G+C+ D E+ C C GF G C+
Sbjct: 474 FQCICMPGYEGVHCEVNTDECAS-SPCLHNGRCL-DKINEFQCECPTGFTGHLCQYDVDE 531
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C A +PC+NG +C D +TC C G+ G CEV++D+C PC G+ C DG+
Sbjct: 532 C--ASTPCKNGAKCLDGPN---TYTCVCTEGYTGTHCEVDIDECDPDPCHYGS-CKDGVA 585
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
F+CLC G+ G C N+++C+S+PC+ G C+DR + + C C G G CE+ L
Sbjct: 586 TFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINL 642
Score = 159 bits (403), Expect = 3e-39
Identities = 79/212 (37%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 46 CRCDPGWEGLHCER---CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHICTTQS 99
CRC PGW G C++ C P G C + C C + G C +D + C Q
Sbjct: 127 CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECG-QK 185
Query: 100 P--CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
P C++GG C ++ G Y CVC G +CER PC SPC+NGG C+ +
Sbjct: 186 PGLCRHGGTC-HNEVGSYRCVCRATHTGPNCERPYVPCSP--SPCQNGGTCRPTGD--VT 240
Query: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCA 217
C CL GF G CE N+DDC C NG C+DG+N ++C CP + G++CT ++D+C
Sbjct: 241 HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ 300
Query: 218 SRP--CQRGARCRDRVHDFDCLCPSGYGGKTC 247
P CQ G C + ++C+C +G+ G+ C
Sbjct: 301 LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332
Score = 158 bits (400), Expect = 7e-39
Identities = 87/249 (34%), Positives = 119/249 (47%), Gaps = 25/249 (10%)
Query: 28 DCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
DC+ G C DG +C C PG+ G +C+ C P GTC ++
Sbjct: 986 DCTESSCFNGGTCV-DGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYR 1044
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
C C G+ G C H C + SPC+NGG+C + +Y C C G+ G C+ + CE
Sbjct: 1045 CTCPQGYTGPNCQNLVHWCDS-SPCKNGGKC-WQTHTQYRCECPSGWTGLYCDVPSVSCE 1102
Query: 137 QAGSP--------CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
A C++GG C D CRC G+ G+ CE VD+C PC NGAT
Sbjct: 1103 VAAQRQGVDVARLCQHGGLCVDAGN---THHCRCQAGYTGSYCEDLVDECSPSPCQNGAT 1159
Query: 189 CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C D + +SC C G+ G C+ +D+C S PCQ G C D + + C CP G G CE
Sbjct: 1160 CTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCE 1219
Query: 249 LVLPVPDPP 257
+ + +PP
Sbjct: 1220 INVDDCNPP 1228
Score = 151 bits (381), Expect = 1e-36
Identities = 83/248 (33%), Positives = 117/248 (47%), Gaps = 21/248 (8%)
Query: 15 CILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG-SCRCDPGWEGLHC----ERCVRMPGC 66
C+ G G + DDC SS CD DG C C+PG+ G C + C P
Sbjct: 629 CLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCH 688
Query: 67 QHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGF 123
GTC + C C G+ C + + C + +PC +G D Y C C PG+
Sbjct: 689 NGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNS-NPCVHGA--CRDSLNGYKCDCDPGW 745
Query: 124 HGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC 183
G +C+ CE +PC NGG C+D + C C GF G C+ N+++C PC
Sbjct: 746 SGTNCDINNNECES--NPCVNGGTCKD---MTSGYVCTCREGFSGPNCQTNINECASNPC 800
Query: 184 ANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR--DRVHDFDCLCPSG 241
N TC+D + + C C + G C + L CA PC+ G CR + F C+CP+G
Sbjct: 801 LNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860
Query: 242 YGGKTCEL 249
+ G+TCE+
Sbjct: 861 WQGQTCEV 868
Score = 149 bits (375), Expect = 5e-36
Identities = 98/298 (32%), Positives = 129/298 (43%), Gaps = 55/298 (18%)
Query: 3 SGCRCL---HLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGL 55
+G +CL + +C G G D D H DG +C C PG+ G
Sbjct: 539 NGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGH 598
Query: 56 HCE----RCVRMPGCQHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
HCE C P C+HG TC + C C G G C+ + C + SPC +G C
Sbjct: 599 HCETNINECSSQP-CRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCAS-SPCDSG-TC 655
Query: 108 MYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD-QGF------------ 154
+ G Y C C PG+ G C C AG+PC NGG C+D GF
Sbjct: 656 LDKIDG-YECACEPGYTGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCRCPEGYHDPT 712
Query: 155 --------------------ALN-FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
+LN + C C G+ G C++N ++C PC NG TC D
Sbjct: 713 CLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMT 772
Query: 194 NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
+ + C C EGF+G C N+++CAS PC C D V + C C Y G TCE+VL
Sbjct: 773 SGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVL 830
Score = 146 bits (369), Expect = 3e-35
Identities = 93/268 (34%), Positives = 121/268 (45%), Gaps = 34/268 (12%)
Query: 38 GCCAPDGS---CRCDPGWEGLHCE----RCVRMPGCQHG-TCHQ---PWQCICHSGWAGK 86
G C G+ CRC G+ G +CE C P CQ+G TC + C C +G+ G
Sbjct: 1120 GLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSP-CQNGATCTDYLGGYSCKCVAGYHGV 1178
Query: 87 FCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP----- 141
C ++ C + PCQNGG C+ D Y C C G G CE C P
Sbjct: 1179 NCSEEIDECLSH-PCQNGGTCL-DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP 1236
Query: 142 -CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT--CLDGINRFSC 198
C N G C D G ++C C GFVG RCE +V++CL PC T C+ +N F C
Sbjct: 1237 KCFNNGTCVDQVG---GYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHC 1293
Query: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCR---DRVHDFDCLCPSGYGGKTCEL------ 249
C G GR C ++ C +PC+ G C + F C CP+G+ G TCE
Sbjct: 1294 ECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCG 1353
Query: 250 VLPVPDPPTTVDTPLGPTSAVVVPATGP 277
L + T + P PT + P TGP
Sbjct: 1354 SLRCLNGGTCISGPRSPTCLCLGPFTGP 1381
Score = 133 bits (334), Expect = 3e-31
Identities = 86/260 (33%), Positives = 119/260 (45%), Gaps = 30/260 (11%)
Query: 10 LVCLLCILGAPGQPVRADDCSSH---CDLAHGCCAPDGS--CRCDPGWEGLHCER---CV 61
L LLC+ P R CS C C A +G+ C C + G C+ C+
Sbjct: 5 LAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCL 64
Query: 62 RMPGCQHGTCH-------QPWQCICHSGWAGKFCDKD-EHICTTQSPCQNGGQCMYDGGG 113
P GTCH + C C G++G C ++ C T +PC+NGG C
Sbjct: 65 STPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLT-NPCRNGGTCDLLTLT 123
Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
EY C C PG+ G+ C+ +A PC A +PC NGGQC F ++ C C F G C
Sbjct: 124 EYKCRCPPGWSGKSCQ-QADPC--ASNPCANGGQCLP---FEASYICHCPPSFHGPTCRQ 177
Query: 174 NVDDCLMRP--CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR--- 228
+V++C +P C +G TC + + + C+C G C C+ PCQ G CR
Sbjct: 178 DVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTG 237
Query: 229 DRVHDFDCLCPSGYGGKTCE 248
D H +C C G+ G+ CE
Sbjct: 238 DVTH--ECACLPGFTGQNCE 255
Score = 127 bits (318), Expect = 2e-29
Identities = 82/251 (32%), Positives = 108/251 (43%), Gaps = 34/251 (13%)
Query: 27 DDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCERCV-----------RMPGC-QHGTC 71
D+C SH G C C C G +G+HCE V R P C +GTC
Sbjct: 1185 DECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTC 1244
Query: 72 HQP---WQCICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRD 127
+ C C G+ G+ C+ D + C + +PC G Q ++HC C G GR
Sbjct: 1245 VDQVGGYSCTCPPGFVGERCEGDVNECLS-NPCDARGTQNCVQRVNDFHCECRAGHTGRR 1303
Query: 128 CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGA 187
CE C+ G PC+NGG C A F C+C GF GA CE + C C NG
Sbjct: 1304 CESVINGCK--GKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGG 1361
Query: 188 TCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDR--------VHDFDCLCP 239
TC+ G +CLC F G C AS PC G C ++ + CLCP
Sbjct: 1362 TCISGPRSPTCLCLGPFTGPECQFP----ASSPCLGGNPCYNQGTCEPTSESPFYRCLCP 1417
Query: 240 SGYGGKTCELV 250
+ + G C ++
Sbjct: 1418 AKFNGLLCHIL 1428
Score = 120 bits (302), Expect = 2e-27
Identities = 81/248 (32%), Positives = 104/248 (41%), Gaps = 24/248 (9%)
Query: 27 DDCS-SHCDLAHGCCAPDG--SCRCDPGWEGLHC----ERCVRMPGCQHGTC---HQPWQ 76
D+CS S C C G SC+C G+ G++C + C+ P GTC ++
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYK 1206
Query: 77 CICHSGWAGKFCDKDEHICT------TQSP-CQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
C C G G C+ + C ++SP C N G C+ GG Y C C PGF G CE
Sbjct: 1207 CSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGG-YSCTCPPGFVGERCE 1265
Query: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
C +PC G Q+ +F C C G G RCE ++ C +PC NG TC
Sbjct: 1266 GDVNEC--LSNPCDARGT-QNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTC 1322
Query: 190 LDGINR---FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKT 246
N F C CP GF G C + C S C G C CLC + G
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPE 1382
Query: 247 CELVLPVP 254
C+ P
Sbjct: 1383 CQFPASSP 1390
Score = 88.2 bits (217), Expect = 1e-17
Identities = 48/132 (36%), Positives = 66/132 (50%), Gaps = 11/132 (8%)
Query: 133 GP-CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC-- 189
GP C Q G C NGG+C+ G C C FVG RC+ + + CL PC N TC
Sbjct: 21 GPRCSQPGETCLNGGKCEAANGTE---ACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHV 76
Query: 190 --LDGINRFSCLCPEGFAGRFCTINLDD-CASRPCQRGARCRD-RVHDFDCLCPSGYGGK 245
G+ ++C C GF+G C LD+ C + PC+ G C + ++ C CP G+ GK
Sbjct: 77 VDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGK 136
Query: 246 TCELVLPVPDPP 257
+C+ P P
Sbjct: 137 SCQQADPCASNP 148
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 186 bits (471), Expect = 4e-47
Identities = 99/287 (34%), Positives = 134/287 (46%), Gaps = 56/287 (19%)
Query: 15 CILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMP 64
C+ G GQ V DDC H L G C DG +C+C P W G C + C P
Sbjct: 224 CLPGFEGQNCEVNVDDCPGHRCLNGGTCV-DGVNTYNCQCPPEWTGQFCTEDVDECQLQP 282
Query: 65 GCQH--GTCHQPW---QCICHSGWAGKFCDKDEHICTT---------------------- 97
H GTC C+C +GW G+ C ++ C T
Sbjct: 283 NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPM 342
Query: 98 --------------QSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKAGPCEQAGSPC 142
+PC C + G C C PGF G C++ C +PC
Sbjct: 343 GKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPC 402
Query: 143 RNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE 202
+ G+C + QG +F C+C G+ G RCE +V++CL PC N ATCLD I +F+C+C
Sbjct: 403 EHLGRCVNTQG---SFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMA 459
Query: 203 GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
GF G +C +++D+C S PC G C+DRV+ F C CPSG+ G TC+L
Sbjct: 460 GFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL 506
Score = 175 bits (443), Expect = 7e-44
Identities = 101/262 (38%), Positives = 126/262 (48%), Gaps = 29/262 (11%)
Query: 2 PSGCRCLHLVCLLCILGAPG----QPVRADDCSSHCDLAHGCCAPDG---SCRCDPGWEG 54
P G RC+ C G G Q + D C S A G C+ DG C C PG +G
Sbjct: 713 PGGFRCV------CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQG 766
Query: 55 LHCE---RCVRMPGCQH-GTCHQ-PWQ---CICHSGWAGKFCDKDEHICTTQSPCQNGGQ 106
CE C P C+H G C P Q C C GW G C +D C +PC G
Sbjct: 767 RQCELLSPCTPNP-CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGI 825
Query: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
C + G + C C G+ G C++ C+ +PC NGG CQD G +F+C CL GF
Sbjct: 826 CT-NLAGSFSCTCHGGYTGPSCDQDINDCDP--NPCLNGGSCQDGVG---SFSCSCLPGF 879
Query: 167 VGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGAR 226
G RC +VD+CL PC G TC D + F+C CP G+ G C +L DC+ C G
Sbjct: 880 AGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT 938
Query: 227 CRDRVHDFDCLCPSGYGGKTCE 248
C D V+ F CLC GY G C+
Sbjct: 939 CVDGVNSFSCLCRPGYTGAHCQ 960
Score = 174 bits (441), Expect = 1e-43
Identities = 99/267 (37%), Positives = 134/267 (50%), Gaps = 28/267 (10%)
Query: 3 SGCRCLHL----VCLLCILGAPGQPVRADD-CSSHCDLAHGCCAPDG-------SCRCDP 50
+G RC L LC G G+ + +D C S G C SCRC
Sbjct: 51 NGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPR 110
Query: 51 GWEGLHC---ERCVRMPGCQHGT-CHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQ 102
G+ G C + C+ P C HG C + C C G+ G+ C D C PC+
Sbjct: 111 GFRGPDCSLPDPCLSSP-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCR 169
Query: 103 NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRC 162
+GG C+ + G + C C G+ G CE A PC A SPCRNGG C+ Q L + C C
Sbjct: 170 HGGTCL-NTPGSFRCQCPAGYTGPLCENPAVPC--APSPCRNGGTCR--QSGDLTYDCAC 224
Query: 163 LVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP-- 220
L GF G CEVNVDDC C NG TC+DG+N ++C CP + G+FCT ++D+C +P
Sbjct: 225 LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA 284
Query: 221 CQRGARCRDRVHDFDCLCPSGYGGKTC 247
C G C + + C+C +G+ G++C
Sbjct: 285 CHNGGTCFNTLGGHSCVCVNGWTGESC 311
Score = 166 bits (421), Expect = 2e-41
Identities = 90/250 (36%), Positives = 125/250 (50%), Gaps = 22/250 (8%)
Query: 14 LCILGAPGQPV--RADDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHC---ERCVRMP 64
+C+ G G+ DDC++ HG D C C G GL C + CV P
Sbjct: 301 VCVNGWTGESCSQNIDDCATAVCF-HGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP 359
Query: 65 GCQHGTCH-QPWQ----CICHSGWAGKFCDKDEHICTT-QSPCQNGGQCMYDGGGEYHCV 118
+ C P C C G+ G CD+D C+ +PC++ G+C+ + G + C
Sbjct: 360 CHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV-NTQGSFLCQ 418
Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
C G+ G CE C PCRN C D G FTC C+ GF G CEV++D+C
Sbjct: 419 CGRGYTGPRCETDVNEC--LSGPCRNQATCLDRIG---QFTCICMAGFTGTYCEVDIDEC 473
Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
PC NG C D +N FSC CP GF+G C +++D+CAS PC+ GA+C D+ ++C C
Sbjct: 474 QSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRC 533
Query: 239 PSGYGGKTCE 248
G+ G C+
Sbjct: 534 AEGFEGTLCD 543
Score = 164 bits (416), Expect = 9e-41
Identities = 103/323 (31%), Positives = 144/323 (44%), Gaps = 67/323 (20%)
Query: 18 GAPGQPVRADDCS---SHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMPGCQH 68
GA Q V D+CS + C+ C GS C+C G+ G CE C+ P
Sbjct: 386 GACDQDV--DECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ 443
Query: 69 GTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
TC + CIC +G+ G +C+ D C + SPC NGG C D + C C GF G
Sbjct: 444 ATCLDRIGQFTCICMAGFTGTYCEVDIDECQS-SPCVNGGVCK-DRVNGFSCTCPSGFSG 501
Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDD---------QGFA--------------------- 155
C+ C A +PCRNG +C D +GF
Sbjct: 502 STCQLDVDEC--ASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRC 559
Query: 156 ----LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTI 211
+F+C C G+ G RCE VD+C +PC +G CLD ++++ C CP G G C +
Sbjct: 560 VDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619
Query: 212 NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL------PVPDPPTTVD---- 261
N+DDCAS PC G CRD ++ +DC+C G+ G C + + P + + VD
Sbjct: 620 NIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENG 678
Query: 262 ----TPLGPTSAVVVPATGPAPH 280
P G + +P + P H
Sbjct: 679 FRCLCPPGSLPPLCLPPSHPCAH 701
Score = 164 bits (416), Expect = 9e-41
Identities = 111/345 (32%), Positives = 142/345 (41%), Gaps = 100/345 (28%)
Query: 4 GCRCLHLV---CLLCILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEG 54
G +CL LV C G G V DDC+S+ G C DG C C PG+ G
Sbjct: 594 GGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN-PCTFGVCR-DGINRYDCVCQPGFTG 651
Query: 55 LHCE------------------------RCVRMPG-----------------CQHGTCHQ 73
C RC+ PG C HG C+
Sbjct: 652 PLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYD 711
Query: 74 P---WQCICHSGWAGKFCDKD--EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
++C+C GW+G C + C +Q PC+ GG C DG G +HC C PG GR C
Sbjct: 712 APGGFRCVCEPGWSGPRCSQSLARDACESQ-PCRAGGTCSSDGMG-FHCTCPPGVQGRQC 769
Query: 129 ERKAGPCEQAGSPCRNGGQCQDDQG----------------------------------- 153
E + PC +PC +GG+C+ G
Sbjct: 770 ELLS-PCTP--NPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826
Query: 154 --FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTI 211
A +F+C C G+ G C+ +++DC PC NG +C DG+ FSC C GFAG C
Sbjct: 827 TNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
Query: 212 NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
++D+C S PC G C D V F C CP GYGG CE LP P
Sbjct: 887 DVDECLSNPCGPGT-CTDHVASFTCTCPPGYGGFHCEQDLPDCSP 930
Score = 161 bits (408), Expect = 8e-40
Identities = 88/241 (36%), Positives = 120/241 (49%), Gaps = 27/241 (11%)
Query: 28 DCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQ 76
DCS G C DG SC C PG+ G HC+ C+ P G C H ++
Sbjct: 927 DCSPSSCFNGGTCV-DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFR 985
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
C C + G C C+ Q PCQNGG+C+ G +C+C PG+ GR C+ ++ PC
Sbjct: 986 CTCLESFTGPQCQTLVDWCSRQ-PCQNGGRCVQTGA---YCLCPPGWSGRLCDIRSLPCR 1041
Query: 137 QAGSP--------CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
+A + C+ GGQC D+ + C C G G+ CE VD CL +PC +G T
Sbjct: 1042 EAAAQIGVRLEQLCQAGGQCVDEDS---SHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGT 1098
Query: 189 CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C + + C C G+ G C ++D+CAS+PCQ G C D V + C CP G G CE
Sbjct: 1099 CRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
Query: 249 L 249
+
Sbjct: 1159 I 1159
Score = 159 bits (403), Expect = 3e-39
Identities = 89/247 (36%), Positives = 115/247 (46%), Gaps = 30/247 (12%)
Query: 26 ADDCSSHCDLAHGCCA---PDGSCRCDPGWEGLHCER----CVRMPGCQHGTCHQPWQ-C 77
AD C S L G C+ P C C + G C+ C R P G C Q C
Sbjct: 963 ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYC 1022
Query: 78 ICHSGWAGKFCDKDEHICTTQSP---------CQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
+C GW+G+ CD C + CQ GGQC+ D ++CVC G G C
Sbjct: 1023 LCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCV-DEDSSHYCVCPEGRTGSHC 1081
Query: 129 ERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
E++ PC PC++GG C+ G+ + C CL G+ G CE +VD+C +PC +G +
Sbjct: 1082 EQEVDPC--LAQPCQHGGTCR---GYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGS 1136
Query: 189 CLDGINRFSCLCPEGFAGRFCTINLDDCASRP-------CQRGARCRDRVHDFDCLCPSG 241
C+D + R+ C CP G G C IN DDC P C C D V F C CP G
Sbjct: 1137 CIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPG 1196
Query: 242 YGGKTCE 248
Y G CE
Sbjct: 1197 YTGLRCE 1203
Score = 139 bits (349), Expect = 6e-33
Identities = 84/231 (36%), Positives = 108/231 (46%), Gaps = 20/231 (8%)
Query: 27 DDCSSH-CDLAHGCC-APDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
D+C+S C C PDG CRC G+EG C+R C P C HG C +
Sbjct: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDP-CHHGRCVDGIASFS 567
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
C C G+ G C+ C +Q PC++GG+C+ D +Y C C G G +CE C
Sbjct: 568 CACAPGYTGTRCESQVDECRSQ-PCRHGGKCL-DLVDKYLCRCPSGTTGVNCEVNIDDC- 624
Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
A +PC G C+D + C C GF G C V +++C PC G +C+DG N F
Sbjct: 625 -ASNPC-TFGVCRDGIN---RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 679
Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
CLCP G C CA PC G C D F C+C G+ G C
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRC 729
Score = 135 bits (340), Expect = 6e-32
Identities = 98/278 (35%), Positives = 120/278 (43%), Gaps = 35/278 (12%)
Query: 33 CDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMPGCQHG-TCHQ---PWQCICHSG 82
C C D S C C G G HCE+ C+ P CQHG TC + C C G
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQP-CQHGGTCRGYMGGYMCECLPG 1113
Query: 83 WAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA-----GPCEQ 137
+ G C+ D C +Q PCQ+GG C+ D Y C C PG G CE GP
Sbjct: 1114 YNGDNCEDDVDECASQ-PCQHGGSCI-DLVARYLCSCPPGTLGVLCEINEDDCGPGPPLD 1171
Query: 138 AGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPC--ANGATCL-DGIN 194
+G C + G C D G F C C G+ G RCE ++++C C A+ CL D
Sbjct: 1172 SGPRCLHNGTCVDLVG---GFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG 1228
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-----DFDCLCPSGYGGKTCEL 249
F CLC GF+G C L C S+PCQ G +CR F C C + G CE
Sbjct: 1229 GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288
Query: 250 V------LPVPDPPTTVDTPLGPTSAVVVPATGPAPHS 281
V L P TP GP A +GP+ S
Sbjct: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRS 1326
Score = 128 bits (322), Expect = 8e-30
Identities = 78/229 (34%), Positives = 105/229 (45%), Gaps = 27/229 (11%)
Query: 38 GCCAPDGS----CRCDPGWEGLHCE---------RCVRMPGCQHGTCHQPWQCICHSGWA 84
G C G C C PG+EG +CE RC+ C G + C C W
Sbjct: 210 GTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGV--NTYNCQCPPEWT 267
Query: 85 GKFCDKDEHICTTQ-SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
G+FC +D C Q + C NGG C GG + CVC+ G+ G C + C A + C
Sbjct: 268 GQFCTEDVDECQLQPNACHNGGTCFNTLGG-HSCVCVNGWTGESCSQNIDDC--ATAVCF 324
Query: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC-LDGIN-RFSCLCP 201
+G C D +F C C +G G C ++ D C+ PC A C + +N R C CP
Sbjct: 325 HGATCHDR---VASFYCACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCP 380
Query: 202 EGFAGRFCTINLDDCA--SRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
GF G C ++D+C+ + PC+ RC + F C C GY G CE
Sbjct: 381 PGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Score = 121 bits (304), Expect = 9e-28
Identities = 64/157 (40%), Positives = 80/157 (50%), Gaps = 7/157 (4%)
Query: 95 CTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD-QG 153
C SPC NGG+C E C+C PG+ G C+ + PC PC G CQ
Sbjct: 43 CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCH--SGPCAGRGVCQSSVVA 99
Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN-RFSCLCPEGFAGRFCTIN 212
F+CRC GF G C + D CL PCA+GA C G + RF C CP G+ GR C +
Sbjct: 100 GTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158
Query: 213 LDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
+D+C PC+ G C + F C CP+GY G CE
Sbjct: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
Score = 118 bits (295), Expect = 1e-26
Identities = 80/259 (30%), Positives = 104/259 (40%), Gaps = 32/259 (12%)
Query: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCE----------RCVRMPGCQH-GTCH 72
D+C+S G C + C C PG G+ CE P C H GTC
Sbjct: 1124 DECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183
Query: 73 Q---PWQCICHSGWAGKFCDKDEHICTTQS-PCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
++C C G+ G C+ D + C + + + C+ D GG + C+C GF G C
Sbjct: 1184 DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243
Query: 129 ERKAGPCEQAGSPCRNGGQCQDDQG--FALNFTCRCLVGFVGARCEVNVDDCLMRPCANG 186
+ PCE PC++GGQC+ G L FTC C F G RCE C C G
Sbjct: 1244 QTVLSPCES--QPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVG 1301
Query: 187 ATCLDGINRFSCLCPEGFAGRFCT--------INLDDCASRPCQRGARCRDR--VHDFDC 236
C C CP G +G C + CA+ PC G CR F C
Sbjct: 1302 VPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRC 1361
Query: 237 LCPSGYGGKTCELVLPVPD 255
C G+ G CE P+
Sbjct: 1362 ACAQGWTGPRCEAPAAAPE 1380
Score = 116 bits (291), Expect = 3e-26
Identities = 65/196 (33%), Positives = 88/196 (44%), Gaps = 19/196 (9%)
Query: 59 RCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYD---GGGEY 115
RC ++P + C+C GW G+ C ++ + PC G C G +
Sbjct: 54 RCTQLPSREAA-------CLCPPGWVGERCQLEDPCHS--GPCAGRGVCQSSVVAGTARF 104
Query: 116 HCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
C C GF G DC PC SPC +G +C G F C C G+ G C +V
Sbjct: 105 SCRCPRGFRGPDCSLP-DPC--LSSPCAHGARCS--VGPDGRFLCSCPPGYQGRSCRSDV 159
Query: 176 DDCLM-RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-D 233
D+C + PC +G TCL+ F C CP G+ G C CA PC+ G CR
Sbjct: 160 DECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLT 219
Query: 234 FDCLCPSGYGGKTCEL 249
+DC C G+ G+ CE+
Sbjct: 220 YDCACLPGFEGQNCEV 235
Score = 56.2 bits (134), Expect = 5e-08
Identities = 32/80 (40%), Positives = 38/80 (47%), Gaps = 10/80 (12%)
Query: 182 PCANGATCLDGINR-FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV----HDFDC 236
PCANG C +R +CLCP G+ G C + D C S PC C+ V F C
Sbjct: 48 PCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFSC 106
Query: 237 LCPSGYGGKTCELVLPVPDP 256
CP G+ G C L PDP
Sbjct: 107 RCPRGFRGPDCSL----PDP 122
Score = 41.2 bits (95), Expect = 0.002
Identities = 82/343 (23%), Positives = 109/343 (31%), Gaps = 98/343 (28%)
Query: 1 MPSGCRCLHL-VCL--------LCILGAPGQPVRAD--DC-SSHCDLAH--GCCAPDGS- 45
+ SG RCLH C+ C G G AD +C S C AH C G
Sbjct: 1170 LDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGG 1229
Query: 46 --CRCDPGWEGLHCER----CVRMPGCQHG---------------TCH--QPW------- 75
C C G+ G C+ C P CQHG TCH QP+
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQP-CQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCER 1288
Query: 76 -----------------------QCICHSGWAGKFCDK-------DEHICTTQSPCQNGG 105
+C C G +G C + +PC +GG
Sbjct: 1289 VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG 1348
Query: 106 QCMYDGGGEY-HCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG-FALNFTCRCL 163
C + C C G+ G CE A E + P CQ +G + C
Sbjct: 1349 SCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSP 1408
Query: 164 -VGFVGARCEVNVDD----CLMRPC---ANGATCLDGINRFSCL-----CPEGFAGRFCT 210
G+ G C ++V D C C N + C + +CL C G R C
Sbjct: 1409 GCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCN 1468
Query: 211 -INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLP 252
+ CA RC + +C G+ G C +P
Sbjct: 1469 PVYEKYCADHFAD--GRCDQGCNTEEC----GWDGLDCASEVP 1505
Score = 32.7 bits (73), Expect = 0.56
Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 1/39 (2%)
Query: 220 PCQRGARCRDRV-HDFDCLCPSGYGGKTCELVLPVPDPP 257
PC G RC + CLCP G+ G+ C+L P P
Sbjct: 48 PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP 86
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 185 bits (470), Expect = 5e-47
Identities = 87/210 (41%), Positives = 118/210 (56%), Gaps = 14/210 (6%)
Query: 46 CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQ 98
C C G+ GL CE C +P +G C + C C SG+ G+ C+++ + C++
Sbjct: 1217 CLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSS- 1275
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
SPC N G C+ DG Y C C+ GF G CE + C+ +PC N C+D G F
Sbjct: 1276 SPCLNKGICV-DGVAGYRCTCVKGFVGLHCETEVNECQS--NPCLNNAVCEDQVG---GF 1329
Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
C+C GF+G RC NVD+CL +PC NGATC DG N F CLC GF G C +N+++C S
Sbjct: 1330 LCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQS 1389
Query: 219 RPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
PC+ A C D ++ + C C G+ GK CE
Sbjct: 1390 NPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 157 bits (396), Expect = 2e-38
Identities = 78/193 (40%), Positives = 100/193 (51%), Gaps = 10/193 (5%)
Query: 60 CVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C P GTC Q + C+C G+ G C+ D C+ PC N G C D GE+
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPL-PCLNNGVCK-DLVGEFI 1254
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
C C G+ G+ CE C + SPC N G C D + C C+ GFVG CE V+
Sbjct: 1255 CECPSGYTGQRCEENINEC--SSSPCLNKGICVDG---VAGYRCTCVKGFVGLHCETEVN 1309
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
+C PC N A C D + F C CP GF G C N+D+C S+PC+ GA C+D + F C
Sbjct: 1310 ECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRC 1369
Query: 237 LCPSGYGGKTCEL 249
LC +G+ G CEL
Sbjct: 1370 LCAAGFTGSHCEL 1382
Score = 76.3 bits (186), Expect = 4e-14
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 3/88 (3%)
Query: 164 VGFVGARCEVNVD---DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRP 220
+G + R E++ +C PC N TC + CLCP G+ G C ++D+C+ P
Sbjct: 1180 LGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLP 1239
Query: 221 CQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C C+D V +F C CPSGY G+ CE
Sbjct: 1240 CLNNGVCKDLVGEFICECPSGYTGQRCE 1267
Score = 73.6 bits (179), Expect = 3e-13
Identities = 37/96 (38%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 38 GCCAPDGSCRCDPGWEGLHCER--CVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHIC 95
G C +C C GW G CE C+ +P G C P+QC C GW G C H
Sbjct: 3480 GICQRPNACSCPEGWMGRLCEEPICI-LPCLNGGRCVAPYQCDCPPGWTGSRC----HTA 3534
Query: 96 TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERK 131
QSPC NGG+C+ C CL + G +C RK
Sbjct: 3535 VCQSPCLNGGKCVRPN----RCHCLSSWTGHNCSRK 3566
Score = 71.2 bits (173), Expect = 1e-12
Identities = 41/115 (35%), Positives = 50/115 (43%), Gaps = 19/115 (16%)
Query: 57 CERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C R P G C +P C C GW G+ C +E IC PC NGG+C+ Y
Sbjct: 3468 CRAVCRFPCQNGGICQRPNACSCPEGWMGRLC--EEPICIL--PCLNGGRCV----APYQ 3519
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
C C PG+ G C C+ SPC NGG+C C CL + G C
Sbjct: 3520 CDCPPGWTGSRCH--TAVCQ---SPCLNGGKCVRPN------RCHCLSSWTGHNC 3563
Score = 56.2 bits (134), Expect = 5e-08
Identities = 36/111 (32%), Positives = 44/111 (39%), Gaps = 21/111 (18%)
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFT 159
PCQNGG C C C G+ GR CE PC NGG+C +
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPI-----CILPCLNGGRC------VAPYQ 3519
Query: 160 CRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
C C G+ G+RC V PC NG C + C C + G C+
Sbjct: 3520 CDCPPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCS 3564
Score = 48.5 bits (114), Expect = 1e-05
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 9/66 (13%)
Query: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
PC NG C +C CPEG+ GR C + PC G RC V + C CP G
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDCPPG 3525
Query: 242 YGGKTC 247
+ G C
Sbjct: 3526 WTGSRC 3531
Score = 46.6 bits (109), Expect = 4e-05
Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 2/77 (2%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQH-GTCHQ 73
C G G+ C C L G C C C PGW G C V C + G C +
Sbjct: 3490 CPEGWMGRLCEEPICILPC-LNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVR 3548
Query: 74 PWQCICHSGWAGKFCDK 90
P +C C S W G C +
Sbjct: 3549 PNRCHCLSSWTGHNCSR 3565
Score = 38.9 bits (89), Expect = 0.008
Identities = 44/155 (28%), Positives = 55/155 (35%), Gaps = 25/155 (16%)
Query: 32 HCDLAHGCCAPDGSCRCDPGW-EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDK 90
H DL G D C EG C C RM C+ GT ++CIC G+ GK
Sbjct: 261 HEDLPSGSFIQDDMVHCSYLCDEGKDC--CDRMGSCKCGTHTGHFECICEKGYYGKGLQY 318
Query: 91 DEHICTTQS--------------PCQNGGQCMYDGG-GEYHCVCLPGFH--GRDCERKAG 133
+ C + + PC + G CVC G+ G+ CE
Sbjct: 319 ECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378
Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTC--RCLVGF 166
P A P NG Q+ N C RC GF
Sbjct: 379 P---ALKPPENGYFIQNTCNNHFNAACGVRCHPGF 410
Score = 37.4 bits (85), Expect = 0.023
Identities = 32/115 (27%), Positives = 43/115 (37%), Gaps = 21/115 (18%)
Query: 27 DDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---W 75
D+C S +G DG+ C C G+ G HCE C P TC +
Sbjct: 1347 DECLSQ-PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSY 1405
Query: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNG--GQCMYDGGGEYHCVCLPGFHGRDC 128
C C G++GK C+ ++ +G G M DG LP H C
Sbjct: 1406 SCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDG-------MLPSLHALTC 1453
Score = 33.5 bits (75), Expect = 0.33
Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 29/104 (27%)
Query: 183 CANGATCLDGIN---------RFSCLCPEGFAGRFCTINLDDCASRPCQRGAR------- 226
C G C D + F C+C +G+ G+ C S +
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340
Query: 227 --CRDRVHDF--------DCLCPSGY--GGKTCELV-LPVPDPP 257
C D H DC+C GY G+TCELV P PP
Sbjct: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPP 384
Score = 29.6 bits (65), Expect = 4.8
Identities = 18/61 (29%), Positives = 24/61 (39%), Gaps = 12/61 (19%)
Query: 185 NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGG 244
+G+ D + S LC EG DC R +C F+C+C GY G
Sbjct: 266 SGSFIQDDMVHCSYLCDEG----------KDCCDR--MGSCKCGTHTGHFECICEKGYYG 313
Query: 245 K 245
K
Sbjct: 314 K 314
Score = 29.3 bits (64), Expect = 6.2
Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 11/77 (14%)
Query: 220 PCQRGARCRDRVHDFDCLCPSGYGGKTCE---LVLPVPD-----PPTTVDTPLGPTSAVV 271
PCQ G C+ C CP G+ G+ CE +LP + P D P G T +
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC 3531
Query: 272 VPATGPAPHSAGAGLLR 288
A +P G +R
Sbjct: 3532 HTAVCQSPCLNGGKCVR 3548
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 184 bits (468), Expect = 9e-47
Identities = 95/240 (39%), Positives = 129/240 (53%), Gaps = 20/240 (8%)
Query: 27 DDCSSH-CDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMPG---CQHG-TCHQPW-- 75
D C S+ C + C G C+C PG+ G CE + G CQHG CHQ
Sbjct: 72 DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIY 131
Query: 76 -QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
CIC +G+AG+FC+ D C + SPCQNG C DG Y C C+PG+ GR C+ +
Sbjct: 132 PVCICPAGYAGRFCEIDHDECAS-SPCQNGAVCQ-DGIDGYSCFCVPGYQGRHCDLEVDE 189
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C A PC+N C ++ G +TC C + G CE+ +D+C +PC NGATC D +
Sbjct: 190 C--ASDPCKNEATCLNEIG---RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALG 244
Query: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCP-SGYGGKTCELVLPV 253
+ C C GF G C +N D+CAS+PC G C D + + C C SG+ G CE ++P+
Sbjct: 245 AYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPL 304
Score = 144 bits (364), Expect = 1e-34
Identities = 90/276 (32%), Positives = 124/276 (44%), Gaps = 45/276 (16%)
Query: 8 LHLVCLLCILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG----SCRCDPGWEGLHCE-- 58
++ VC+ C G G+ + D+C SS C +G DG SC C PG++G HC+
Sbjct: 130 IYPVCI-CPAGYAGRFCEIDHDECASSPCQ--NGAVCQDGIDGYSCFCVPGYQGRHCDLE 186
Query: 59 --RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGG 113
C P TC + CIC ++G C+ + C +Q PC NG C D G
Sbjct: 187 VDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQ-PCLNGATCQ-DALG 244
Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL-VGFVGARCE 172
Y C C PGF G CE C A PC +GG C D + ++C C GF G CE
Sbjct: 245 AYFCDCAPGFLGDHCELNTDEC--ASQPCLHGGLCVDGEN---RYSCNCTGSGFTGTHCE 299
Query: 173 VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD--- 229
+ C +PC N ATC D ++ ++C C G+ G C I+L++C S PCQ C +
Sbjct: 300 TLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSS 359
Query: 230 -----------------RVHDFDCLCPSGYGGKTCE 248
+ C+C G+ G CE
Sbjct: 360 EKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE 395
Score = 137 bits (346), Expect = 1e-32
Identities = 63/165 (38%), Positives = 90/165 (54%), Gaps = 7/165 (4%)
Query: 86 KFCDKDEHICTTQSPCQNGGQCMYDGGGE-YHCVCLPGFHGRDCERKAGPCEQAGSPCRN 144
K CD + C + +PCQ C+ G + C C PG+ G CE G C + + C++
Sbjct: 65 KDCDNMKDPCFS-NPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGK--NSCQH 121
Query: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
GG C D + + C C G+ G CE++ D+C PC NGA C DGI+ +SC C G+
Sbjct: 122 GGICHQDPIYPV---CICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGY 178
Query: 205 AGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
GR C + +D+CAS PC+ A C + + + C+CP Y G CEL
Sbjct: 179 QGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCEL 223
Score = 128 bits (321), Expect = 1e-29
Identities = 72/202 (35%), Positives = 91/202 (45%), Gaps = 21/202 (10%)
Query: 29 CSSHCDLAHGCCAPDGS---CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCI 78
C+S+ L G C S C C GW G HCE C P C HG C + C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCT 1201
Query: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC--- 135
C G+ G C+ D C + C NG C+ G Y C+C F G+ C + P
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQ-CANGATCISHTNG-YSCLCFGNFTGKFCRQSRLPSTVC 1259
Query: 136 --EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
E+ C NGG C + F C C GF G CE ++D+C PC NG C D +
Sbjct: 1260 GNEKTNLTCYNGGNCTE---FQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316
Query: 194 NRFSCLCPEGFAGRFCTINLDD 215
N+F CLC FAG C ++L D
Sbjct: 1317 NKFQCLCDVAFAGERCEVDLAD 1338
Score = 127 bits (320), Expect = 1e-29
Identities = 76/239 (31%), Positives = 101/239 (42%), Gaps = 39/239 (16%)
Query: 46 CRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPWQCICH-SGWAGKFCDKDEHICTT 97
C C PG+ G HCE C P G C + C C SG+ G C+ +C +
Sbjct: 248 CDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307
Query: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD------- 150
+ PC N C D Y C C PG+ G CE C +PC++ G+C +
Sbjct: 308 K-PCHNNATCE-DSVDNYTCHCWPGYTGAQCEIDLNECNS--NPCQSNGECVELSSEKQY 363
Query: 151 ----------DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
A + C C GF G CE +V++C PC NG TC + ++C C
Sbjct: 364 GRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423
Query: 201 P------EGFAGRFCTINLDDCASRPCQRGARC----RDRVHDFDCLCPSGYGGKTCEL 249
P + GR C+ L C + C C +D H F CLCPSGY G CE+
Sbjct: 424 PFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482
Score = 117 bits (293), Expect = 2e-26
Identities = 66/223 (29%), Positives = 99/223 (44%), Gaps = 19/223 (8%)
Query: 60 CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C P G C + + C C GW+GK C+ + C + +PC +G D YH
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFS-NPCIHGN--CSDRVAAYH 1199
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE---- 172
C C PG+ G +CE C+ C NG C ++C C F G C
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQS--HQCANGATCISHTN---GYSCLCFGNFTGKFCRQSRL 1254
Query: 173 ---VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
V ++ C NG C + C+C GF G +C ++D+CAS PC G C+D
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQD 1314
Query: 230 RVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVV 272
++ F CLC + G+ CE+ L D + + T +G + ++
Sbjct: 1315 LLNKFQCLCDVAFAGERCEVDL-ADDLISDIFTTIGSVTVALL 1356
Score = 55.5 bits (132), Expect = 8e-08
Identities = 35/139 (25%), Positives = 50/139 (35%), Gaps = 46/139 (33%)
Query: 154 FALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLD---------------------- 191
F L+F+ L+ + C N CL C N +TC D
Sbjct: 12 FYLSFSL--LIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDN 69
Query: 192 --------------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC-RDR 230
G F C CP G++G C + C CQ G C +D
Sbjct: 70 MKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDP 129
Query: 231 VHDFDCLCPSGYGGKTCEL 249
++ C+CP+GY G+ CE+
Sbjct: 130 IYPV-CICPAGYAGRFCEI 147
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/75 (29%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 176 DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD 235
+ C PC NG C + FSC CP +G+ C + C PC GA+C+ + F+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 236 CLCPSGYGGKTCELV 250
C+ + + G++ +++
Sbjct: 948 CIANAVFNGQSGQIL 962
Score = 44.3 bits (103), Expect = 2e-04
Identities = 17/39 (43%), Positives = 21/39 (53%)
Query: 211 INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
+ L+ C S PC G C D + C CP G+ GK CEL
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCEL 1176
Score = 42.7 bits (99), Expect = 5e-04
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 4/76 (5%)
Query: 132 AGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLD 191
AG +PC NGG C +F+C C G CE V C PC +GA C
Sbjct: 886 AGDNSCKSNPCHNGGVCHSRWD---DFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQP 941
Query: 192 GINRFSCLCPEGFAGR 207
+ F C+ F G+
Sbjct: 942 VLQGFECIANAVFNGQ 957
Score = 37.7 bits (86), Expect = 0.017
Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 20/90 (22%)
Query: 40 CAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPW---QCICHSGWAGKFCDKDEHICT 96
CA D SC+ +P G G CH W C C + +GK C++ +
Sbjct: 885 CAGDNSCKSNPCHNG--------------GVCHSRWDDFSCSCPALTSGKACEEVQ--WC 928
Query: 97 TQSPCQNGGQCMYDGGGEYHCVCLPGFHGR 126
SPC +G QC G + C+ F+G+
Sbjct: 929 GFSPCPHGAQCQPVLQG-FECIANAVFNGQ 957
Score = 31.2 bits (69), Expect = 1.6
Identities = 13/37 (35%), Positives = 17/37 (45%)
Query: 211 INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
+ D C S+PCQ RC + + C C Y G C
Sbjct: 671 VRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 177 bits (450), Expect = 1e-44
Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)
Query: 29 CSSHCDLAHGCCAPDGSCRCDPGWEGLHCE---------------------------RCV 61
C + C HG C G CRC GW G C C
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 62 RMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
P G+C + ++C C G+ G C+ C PC NGG C+ D Y
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC-ADGPCFNGGLCVGGADPDSAYI 338
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
C C PGF G +CE++ C PCRNGG C D G AL CRC GF G RCE ++D
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCL-DLGHALR--CRCRAGFAGPRCEHDLD 393
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
DC R CANG TC++G C C GF GR C D CA+RPC G RC C
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453
Query: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
C GY G CE PV PD + + P P ++ PA G A AGA LL
Sbjct: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511
Query: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
+ V+ Q+ AG EPS+ AL
Sbjct: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 177 bits (450), Expect = 1e-44
Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)
Query: 29 CSSHCDLAHGCCAPDGSCRCDPGWEGLHCE---------------------------RCV 61
C + C HG C G CRC GW G C C
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 62 RMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
P G+C + ++C C G+ G C+ C PC NGG C+ D Y
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC-ADGPCFNGGLCVGGADPDSAYI 338
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
C C PGF G +CE++ C PCRNGG C D G AL CRC GF G RCE ++D
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCL-DLGHALR--CRCRAGFAGPRCEHDLD 393
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
DC R CANG TC++G C C GF GR C D CA+RPC G RC C
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453
Query: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
C GY G CE PV PD + + P P ++ PA G A AGA LL
Sbjct: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511
Query: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
+ V+ Q+ AG EPS+ AL
Sbjct: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 169 bits (427), Expect = 5e-42
Identities = 102/299 (34%), Positives = 138/299 (46%), Gaps = 43/299 (14%)
Query: 15 CILGAPGQP--VRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMP 64
C LG G + D+C+S L G C DG C C PG+ G C+ C P
Sbjct: 134 CPLGYAGVTCEMEVDECASAPCLHGGSCL-DGVGSFRCVCAPGYGGTRCQLDLDECQSQP 192
Query: 65 GCQHGTCHQ---PWQCICH-SGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
GTCH ++C C +G+ G C+++ C + +PC++ C+ +G G + C+C
Sbjct: 193 CAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECAS-APCEHNASCL-EGLGSFRCLCW 250
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFAL------------------NFTCRC 162
PG+ G CE C A SPC++GG+C AL F C C
Sbjct: 251 PGYSGELCEVDEDEC--ASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHC 308
Query: 163 LVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
GF GA C V VD+C RPC NG C D N F C CP+G+AG C ++D+C S PC
Sbjct: 309 PPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCL 368
Query: 223 RGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHS 281
G C D V + C CP +GG+ C + L T P +A +P HS
Sbjct: 369 HGGTCSDTVAGYICRCPETWGGRDCSVQL------TGCQGHTCPLAATCIPIFESGVHS 421
Score = 165 bits (417), Expect = 7e-41
Identities = 130/403 (32%), Positives = 164/403 (40%), Gaps = 84/403 (20%)
Query: 27 DDCSSHCDLAHGCCAPD--GSCRCD---PGWEGLHCER----CVRMPGCQHG-TCHQ--- 73
D+C S AHG D RCD G+EG HCER C P C+H +C +
Sbjct: 186 DECQSQ-PCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAP-CEHNASCLEGLG 243
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM-------YDG-------------GG 113
++C+C G++G+ C+ DE C + SPCQ+GG+C+ Y G
Sbjct: 244 SFRCLCWPGYSGELCEVDEDECAS-SPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAA 302
Query: 114 EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
+ C C PGF G DC + C A PC NGG CQD F C C G+ G CE
Sbjct: 303 GFLCHCPPGFEGADCGVEVDEC--ASRPCLNGGHCQD---LPNGFQCHCPDGYAGPTCEE 357
Query: 174 NVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC----RD 229
+VD+CL PC +G TC D + + C CPE + GR C++ L C C A C
Sbjct: 358 DVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFES 417
Query: 230 RVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGP--------APHS 281
VH + C CP G G C TT G VPA GP
Sbjct: 418 GVHSYVCHCPPGTHGPFC-------GQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLP 470
Query: 282 AGAGLLRISVKE------VVRRQEAGLGEPSLVALVV-----------FGALTAALVLAT 324
AG R KE V +A L S LV+ + + L LAT
Sbjct: 471 AGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLAT 530
Query: 325 VLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQECQVSMLPAGL 367
L LR W G CP C P + LPAG+
Sbjct: 531 --LELRLWHEG-CPARLCVAS----GPVALASTASATPLPAGI 566
Score = 157 bits (398), Expect = 1e-38
Identities = 88/248 (35%), Positives = 116/248 (46%), Gaps = 45/248 (18%)
Query: 37 HGC-CAPDGS------CRCDPGWEGLHCE----RCVRMPGCQHG-TCH---QPWQCICHS 81
HG C P G C C PG++G CE C P C HG TC ++C C
Sbjct: 78 HGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRP-CHHGATCRNLADRYECHCPL 136
Query: 82 GWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP 141
G+AG C+ + C + +PC +GG C+ DG G + CVC PG+ G C+ C+ P
Sbjct: 137 GYAGVTCEMEVDECAS-APCLHGGSCL-DGVGSFRCVCAPGYGGTRCQLDLDECQ--SQP 192
Query: 142 CRNGGQCQDDQGFALNFTCRCL-VGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
C +GG C D F C C G+ G CE V +C PC + A+CL+G+ F CLC
Sbjct: 193 CAHGGTCHD---LVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLC 249
Query: 201 PEGFAGRFCTINLDDCASRPCQRGARCRDR---------------------VHDFDCLCP 239
G++G C ++ D+CAS PCQ G RC R F C CP
Sbjct: 250 WPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCP 309
Query: 240 SGYGGKTC 247
G+ G C
Sbjct: 310 PGFEGADC 317
Score = 138 bits (347), Expect = 9e-33
Identities = 63/157 (40%), Positives = 86/157 (54%), Gaps = 9/157 (5%)
Query: 95 CTTQSPCQNGGQCMYDGGGE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQ 152
C TQ PC +G C+ G + C C+PGF G CE C A PC +G C++
Sbjct: 71 CATQ-PCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDEC--ASRPCHHGATCRN-- 125
Query: 153 GFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN 212
A + C C +G+ G CE+ VD+C PC +G +CLDG+ F C+C G+ G C ++
Sbjct: 126 -LADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLD 184
Query: 213 LDDCASRPCQRGARCRDRVHDFDCLCP-SGYGGKTCE 248
LD+C S+PC G C D V+ F C C +GY G CE
Sbjct: 185 LDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 221
Score = 127 bits (320), Expect = 1e-29
Identities = 61/155 (39%), Positives = 78/155 (50%), Gaps = 18/155 (11%)
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG---SPCRNGGQCQDDQGFAL 156
PC G +C G Y C GP E G PC +G C
Sbjct: 46 PCAPGTECQATESGGYTC---------------GPMEPRGCATQPCHHGALCVPQGPDPT 90
Query: 157 NFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDC 216
F C C+ GF G RCE+++D+C RPC +GATC + +R+ C CP G+AG C + +D+C
Sbjct: 91 GFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150
Query: 217 ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
AS PC G C D V F C+C GYGG C+L L
Sbjct: 151 ASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDL 185
Score = 100 bits (250), Expect = 2e-21
Identities = 71/213 (33%), Positives = 91/213 (42%), Gaps = 19/213 (8%)
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
SPC + G C D + C C PG+ G CE PC A PC G G F
Sbjct: 1063 SPCLHDGACR-DLFDAFACACGPGWEGPRCEAHVDPCHSA--PCARGRCHTHPDG---RF 1116
Query: 159 TCRCLVGFVGARCEVNVD--DCLMR-PCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
CRC GF G RC + V +C + C +G+ C G +C C EG AG+ C +
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176
Query: 216 CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV--LPVPDPPTTVDTPLGPTSAVVVP 273
C + PC G CR +C+C + + G+ CE+ LP+P P P V VP
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLP--------FPLLEVAVP 1228
Query: 274 ATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPS 306
A GLL + RRQ G PS
Sbjct: 1229 AACACLLLLLLGLLSGILAARKRRQSEGTYSPS 1261
Score = 80.9 bits (198), Expect = 2e-15
Identities = 57/173 (32%), Positives = 69/173 (39%), Gaps = 26/173 (15%)
Query: 20 PGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCER----CVRMPGC 66
PG P C A C DG+CR C PGWEG CE C P C
Sbjct: 1045 PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP-C 1103
Query: 67 QHGTCHQ----PWQCICHSGWAGKFC--DKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
G CH ++C C G+ G C C+ C +G C G +C CL
Sbjct: 1104 ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPC-EGGSPAANCSCL 1162
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEV 173
G G+ C+ PCE +PC NGG C+ G + C C F G CEV
Sbjct: 1163 EGLAGQRCQVPTLPCE--ANPCLNGGTCRAAGGVS---ECICNARFSGQFCEV 1210
Score = 66.2 bits (160), Expect = 5e-11
Identities = 30/76 (39%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 178 CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD-FDC 236
C PC + C D + F+C C G+ G C ++D C S PC RG RC F+C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118
Query: 237 LCPSGYGGKTCELVLP 252
CP G+GG C L +P
Sbjct: 1119 RCPPGFGGPRCRLPVP 1134
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/160 (29%), Positives = 59/160 (36%), Gaps = 14/160 (8%)
Query: 24 VRADDCSSHCDLAHGCCA--PDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP-- 74
V D+C+S L G C P+G C C G+ G CE C+ P GTC
Sbjct: 319 VEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVA 378
Query: 75 -WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM---YDGGGEYHCVCLPGFHGRDCER 130
+ C C W G+ C C + C C+ G Y C C PG HG C +
Sbjct: 379 GYICRCPETWGGRDCSVQLTGCQGHT-CPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQ 437
Query: 131 KAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
AGSP + G AL F G + R
Sbjct: 438 NTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATR 477
Score = 50.8 bits (120), Expect = 2e-06
Identities = 33/109 (30%), Positives = 43/109 (39%), Gaps = 17/109 (15%)
Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
P + + P GG+ + N T C V+ D C PC NG TCL
Sbjct: 783 PLDNSSQPSELGGRQ------SWNLTAGC----------VSEDMCSPDPCFNGGTCLVTW 826
Query: 194 NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
N F C CP F G C L C +PC A C + F C+ + +
Sbjct: 827 NDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATF 874
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/47 (36%), Positives = 23/47 (48%)
Query: 211 INLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPP 257
++ D C+ PC G C +DF C CP+ + G TC L P P
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQP 852
Score = 35.4 bits (80), Expect = 0.087
Identities = 41/152 (26%), Positives = 51/152 (33%), Gaps = 32/152 (21%)
Query: 166 FVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
F G +V VD L+ P G L G R + C PC G
Sbjct: 576 FAGCLQDVRVDGHLLLPEDLGENVLLGCER-----------------REQCRPLPCVHGG 618
Query: 226 RCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAG 285
C D F C C + G TC +P T P+SA + P P+ +
Sbjct: 619 SCVDLWTHFRCDCARPHRGPTCADEIPA----ATFGLGGAPSSASFLLQELPGPNLTVSF 674
Query: 286 LLRISVKEVVRRQEAGL----GEPSLVALVVF 313
LLR R+ AGL S L VF
Sbjct: 675 LLR-------TRESAGLLLQFANDSAAGLTVF 699
Score = 35.0 bits (79), Expect = 0.11
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 5/59 (8%)
Query: 92 EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQD 150
E +C+ PC NGG C+ ++HC C F G C ++ C G PC C++
Sbjct: 808 EDMCSPD-PCFNGGTCLVTWN-DFHCTCPANFTGPTCAQQLW-C--PGQPCLPPATCEE 861
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 164 bits (415), Expect = 1e-40
Identities = 88/223 (39%), Positives = 114/223 (51%), Gaps = 21/223 (9%)
Query: 46 CRCDPGWEGLHC----ERCVRMPG----CQHG-TCHQP---WQCICHSGWAGKFCDKDEH 93
C C PG+ G C + C+ C+HG +C + C+C G+ G C+ D +
Sbjct: 418 CLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHN 477
Query: 94 ICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG 153
C +Q PC G C+ D +HC+C PG G+ CE + C A +PC N C D
Sbjct: 478 ECLSQ-PCHPGSTCL-DLLATFHCLCPPGLEGQLCEVETNEC--ASAPCLNHADCHD--- 530
Query: 154 FALN-FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN 212
LN F C CL GF G RCE ++D+C PCANG C D F C C GF G C
Sbjct: 531 -LLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTE 589
Query: 213 LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPD 255
+D+C S PC GA C D F CLCPSG+ G+ CE+ L P+
Sbjct: 590 VDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN 632
Score = 159 bits (403), Expect = 3e-39
Identities = 84/239 (35%), Positives = 117/239 (48%), Gaps = 22/239 (9%)
Query: 27 DDCSS----HCDLAHGCCAPDGS--CRCDPGWEGLHCER----CVRMPGCQHGTCHQ--- 73
D+C + HC C GS C C GW G CE C+ TC
Sbjct: 316 DECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVG 375
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG-GGEYHCVCLPGFHGRDCERKA 132
+ C+C G G C ++ +C +Q PC QC + G C+C PG+ G C +
Sbjct: 376 SFSCLCPPGRTGLLCHLED-MCLSQ-PCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDL 433
Query: 133 GPC---EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
C +Q SPC +GG C + G +F C C G+ G+RCE + ++CL +PC G+TC
Sbjct: 434 DECLMAQQGPSPCEHGGSCLNTPG---SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTC 490
Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
LD + F CLCP G G+ C + ++CAS PC A C D ++ F C+C G+ G CE
Sbjct: 491 LDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE 549
Score = 157 bits (397), Expect = 2e-38
Identities = 96/254 (37%), Positives = 122/254 (48%), Gaps = 25/254 (9%)
Query: 15 CILGAPGQPVRADD-CSSHCDLAHGCCA---PDGSCRCDPGWEGLHCER----CVRMPG- 65
C+ G G+ + D CS++ + G C P C C PG+EG CER C + PG
Sbjct: 145 CMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGP 204
Query: 66 CQHGT-CHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC--MYDGGGEYH-CV 118
C GT CH +QC+C G G C+ C + C NGG C M + +H C+
Sbjct: 205 CPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG-CSNGGTCQLMPEKDSTFHLCL 263
Query: 119 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
C PGF G DCE C C+NGG CQD +TC C + G C +VD+C
Sbjct: 264 CPPGFIGPDCEVNPDNC--VSHQCQNGGTCQDGLD---TYTCLCPETWTGWDCSEDVDEC 318
Query: 179 LMRP---CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD 235
+ C NG TC + F C+C G+ G C NLDDC + C G+ C DRV F
Sbjct: 319 ETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFS 378
Query: 236 CLCPSGYGGKTCEL 249
CLCP G G C L
Sbjct: 379 CLCPPGRTGLLCHL 392
Score = 144 bits (363), Expect = 1e-34
Identities = 80/240 (33%), Positives = 110/240 (45%), Gaps = 28/240 (11%)
Query: 45 SCRCDPGWEGLHCERCVRMPGCQHGTCH---------QPWQCICHSGWAGKFCDKDEHIC 95
SC C G++G CE +R P C C Q +C+C +G+ G C +C
Sbjct: 790 SCLCAMGFQGPRCEGKLR-PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLC 848
Query: 96 TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG--------SPCRNGGQ 147
Q PC C+ G +HC+CL G+ G C C++A S C NGG
Sbjct: 849 A-QKPCPRNSHCLQTGPS-FHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906
Query: 148 CQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGR 207
C D ++ C C GF G+ C+ +V+ C RPC NGATC+ + + C C G+ G+
Sbjct: 907 CVDS---GPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQ 963
Query: 208 FCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPT 267
C+ LD C S+PC C + F C CP G+ G CE D +D P PT
Sbjct: 964 NCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCE-----GDVDECLDQPCHPT 1018
Score = 138 bits (348), Expect = 7e-33
Identities = 89/285 (31%), Positives = 118/285 (41%), Gaps = 39/285 (13%)
Query: 14 LCILGAPGQ----PVRADDCSSHCDLAHGCC-APDGS-CRCDPGWEGLHCER----CVRM 63
LC +G G +R S C C +P G C C G+ G C+ C +
Sbjct: 792 LCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQK 851
Query: 64 PGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICT---------TQSPCQNGGQCMYDG 111
P ++ C Q + C+C GW G C+ C S C NGG C+ D
Sbjct: 852 PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCV-DS 910
Query: 112 GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
G Y C C PGF G C+ PCE PC+NG C + C+C G+ G C
Sbjct: 911 GPSYFCHCPPGFQGSLCQDHVNPCESR--PCQNGATCMAQPS---GYLCQCAPGYDGQNC 965
Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRG--ARCRD 229
+D C +PC N TC F C CP GF G C ++D+C +PC A C
Sbjct: 966 SKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHS 1025
Query: 230 RVHDFDCLCPSGYGGKTCELVL-PVPDPP--------TTVDTPLG 265
+ F C C G+ G+ CE+ + P P T +PLG
Sbjct: 1026 LANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLG 1070
Score = 137 bits (344), Expect = 2e-32
Identities = 87/310 (28%), Positives = 115/310 (37%), Gaps = 81/310 (26%)
Query: 14 LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCR---------CDPGWEGLHCE----RC 60
LC G G AD H + C P +C C PG EG CE C
Sbjct: 462 LCPPGYTGSRCEAD----HNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC 517
Query: 61 VRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHC 117
P H CH +QCIC G++G C++D C + SPC NGGQC D G +HC
Sbjct: 518 ASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRS-SPCANGGQCQ-DQPGAFHC 575
Query: 118 VCLPGFHGRDCERKAGPC------------------------------------------ 135
CLPGF G C+ + C
Sbjct: 576 KCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQ 635
Query: 136 ---------EQAGSPCRNGG--------QCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
++A C +G C G +C C VG+ G CE + C
Sbjct: 636 PKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGC 695
Query: 179 LMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
+ PCA+G TC + ++C CP G+ G C+ + C S PC G C + C C
Sbjct: 696 ISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTC 755
Query: 239 PSGYGGKTCE 248
P + G C+
Sbjct: 756 PPSHTGPQCQ 765
Score = 125 bits (313), Expect = 8e-29
Identities = 87/306 (28%), Positives = 121/306 (39%), Gaps = 48/306 (15%)
Query: 14 LCILGAPGQPVRAD--DC-SSHCDLAHGCCAPDGS--CRCDPGWEGLHCE----RCVRMP 64
+C+ G G D +C SS C C G+ C+C PG+EG C+ C+ P
Sbjct: 538 ICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDP 597
Query: 65 GCQHGTCHQ---PWQCICHSGWAGKFCD---------KDEHICTTQ-------------- 98
+C + C+C SG+ G+ C+ + + IC Q
Sbjct: 598 CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG 657
Query: 99 -SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
+P ++ C + CVC G+ G +CE + G C A PC +GG C
Sbjct: 658 CAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISA--PCAHGGTCYPQPS---G 712
Query: 158 FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCA 217
+ C C G+ G C + C PC NG +C + C CP G C + D C
Sbjct: 713 YNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCV 772
Query: 218 SRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-------PVPDPPTTVDTPLGPTSAV 270
S PC G C +R F CLC G+ G CE L P + T D+P GP
Sbjct: 773 SAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLC 832
Query: 271 VVPATG 276
TG
Sbjct: 833 PTGYTG 838
Score = 122 bits (307), Expect = 4e-28
Identities = 86/311 (27%), Positives = 113/311 (36%), Gaps = 68/311 (21%)
Query: 2 PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCA---PDGSCRCDPGWEGLHCE 58
PS L L+ LLC+ + + C C + G+C+C PG+ G C+
Sbjct: 4 PSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQ 63
Query: 59 ---RCVRMPGCQHGTCHQP------------------WQCICHSGWAGKFCDKDEHICTT 97
C CQ+G Q + C C G+ G+ C
Sbjct: 64 FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCP 123
Query: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRD------------------------------ 127
S C G+C G C C+PG+ G
Sbjct: 124 PSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCP 183
Query: 128 -------CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 180
CER C Q PC G C + G +F C C VG G RCE+ C
Sbjct: 184 PGFEGHACERDVNECFQDPGPCPKGTSCHNTLG---SFQCLCPVGQEGPRCELRAGPCPP 240
Query: 181 RPCANGATCLDGINRFS----CLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
R C+NG TC + S CLCP GF G C +N D+C S CQ G C+D + + C
Sbjct: 241 RGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC 300
Query: 237 LCPSGYGGKTC 247
LCP + G C
Sbjct: 301 LCPETWTGWDC 311
Score = 107 bits (266), Expect = 2e-23
Identities = 71/238 (29%), Positives = 90/238 (37%), Gaps = 21/238 (8%)
Query: 30 SSHCDLAHGCCA-PDGS-CRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICH 80
S C C A P G C+C PG++G +C + C P HGTC + C C
Sbjct: 936 SRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACP 995
Query: 81 SGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
G+ G C+ D C Q G + ++C CLPG G+ CE + PC
Sbjct: 996 PGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHS--Q 1053
Query: 141 PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF---S 197
PC +GG C+ G L F C C GF G C C C +G CL
Sbjct: 1054 PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPR 1113
Query: 198 CLCPEGFAGRFCTI--NLDDCA-SRPCQRGARCRDRV----HDFDCLCPSGYGGKTCE 248
C C G+ G C C PC C + F C CP G C+
Sbjct: 1114 CACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171
Score = 49.3 bits (116), Expect = 6e-06
Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 17/93 (18%)
Query: 182 PCANGATCLD-GINRFSCLCPEGFAGRFCTINLDDCASRP-CQRGARCRDRVH------- 232
PCANG TCL + + +C C GF G C D C + CQ G C+ +
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQNAQLCQNGGSCQALLPAPLGLPS 92
Query: 233 -------DFDCLCPSGYGGKTCELVLPVPDPPT 258
F C C G+ G+ C+ L P PP+
Sbjct: 93 SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPS 125
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 152 bits (383), Expect = 6e-37
Identities = 83/243 (34%), Positives = 123/243 (50%), Gaps = 36/243 (14%)
Query: 40 CAPDGSCRCDP----------GWEGLHCE----RCVRMPGCQHG-TCH------QPWQCI 78
C DG+C DP G++G C+ C+ P C+HG TCH + CI
Sbjct: 927 CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCI 985
Query: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
C G+ G+ C+ + C + C+N C+ DG Y C+C P + G CE K C Q
Sbjct: 986 CADGFEGENCEVNVDDCE-DNDCENNSTCV-DGINNYTCLCPPEYTGELCEEKLDFCAQD 1043
Query: 139 GSPCRNGGQC-QDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFS 197
+PC++ +C +GF C C G+VG C+++ DDC C NGA C D +N ++
Sbjct: 1044 LNPCQHDSKCILTPKGFK----CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
Query: 198 CLCPEGFAGRFCTIN-------LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
C+CPEG++G FC + C + CQ GA+C R+++ C C GY G+ CE +
Sbjct: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
Query: 251 LPV 253
+ V
Sbjct: 1160 VSV 1162
Score = 143 bits (360), Expect = 3e-34
Identities = 71/201 (35%), Positives = 91/201 (45%), Gaps = 42/201 (20%)
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
+PC+N G C D Y C C GF G+DC+ C +PC++GG C +G F
Sbjct: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC--ISNPCKHGGTCHLKEGEEDGF 982
Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPE---------------- 202
C C GF G CEVNVDDC C N +TC+DGIN ++CLCP
Sbjct: 983 WCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQ 1042
Query: 203 ------------------------GFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
G+ G C I+ DDC C+ GA C D V+ + C+C
Sbjct: 1043 DLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCIC 1102
Query: 239 PSGYGGKTCELVLPVPDPPTT 259
P GY G CE P+ P T+
Sbjct: 1103 PEGYSGLFCEFSPPMVLPRTS 1123
Score = 67.8 bits (164), Expect = 2e-11
Identities = 49/158 (31%), Positives = 67/158 (42%), Gaps = 30/158 (18%)
Query: 36 AHGCCAPDG----SCRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGW 83
AHG C P +C C GW G C++ P C HGTC + C C G
Sbjct: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGH 1401
Query: 84 AGKFCDKDEHICTTQSPCQ----NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
G CD++E + +PCQ G+C G G+ +C C G+ G C+R+ C G
Sbjct: 1402 GGVLCDEEEDLF---NPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR--G 1455
Query: 140 SPCRNGGQCQDDQGFALNFTCR------CLVGFVGARC 171
R+ Q QG+A T + C G G +C
Sbjct: 1456 ERIRD--YYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
Score = 57.4 bits (137), Expect = 2e-08
Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 12/121 (9%)
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD-CLMRPCANGATCLDGI 193
CE G CQ FTC C G++G C+ +D CL C +G TCL I
Sbjct: 1333 CEPCHKKVCAHGTCQPSS--QAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLP-I 1388
Query: 194 NRFS--CLCPEGFAGRFCTINLD---DCASRPCQRGARCR-DRVHDFDCLCPSGYGGKTC 247
N FS C C EG G C D C + C+ G +CR + C C SGY G +C
Sbjct: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSC 1447
Query: 248 E 248
+
Sbjct: 1448 D 1448
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/204 (25%), Positives = 73/204 (35%), Gaps = 42/204 (20%)
Query: 57 CERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNG----GQCM 108
CE C + C HGTC Q C C GW G CD+ T PC G C+
Sbjct: 1333 CEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQ-----RTNDPCLGNKCVHGTCL 1386
Query: 109 YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR----NGGQCQDDQGFALNFTCRCLV 164
Y C CL G G C+ + E +PC+ G+C+ G + C C
Sbjct: 1387 PINAFSYSCKCLEGHGGVLCDEE----EDLFNPCQAIKCKHGKCR-LSGLGQPY-CECSS 1440
Query: 165 GFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLD------DCAS 218
G+ G C+ + G D + +G+A T + CA
Sbjct: 1441 GYTGDSCDREIS-------CRGERIRDYYQK-----QQGYAACQTTKKVSRLECRGGCAG 1488
Query: 219 RPCQRGARCRDRVHDFDCLCPSGY 242
C R + R + F+C S +
Sbjct: 1489 GQCCGPLRSKRRKYSFECTDGSSF 1512
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 150 bits (379), Expect = 2e-36
Identities = 75/201 (37%), Positives = 90/201 (44%), Gaps = 44/201 (21%)
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
SPCQN G C D Y C C G+ GRDCE C + PC NGG C +G F
Sbjct: 932 SPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC--SSGPCENGGTCHAQEGEDAPF 989
Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCP----------------- 201
TC C GF G C VN DDC+ CANG C+DG+ ++C CP
Sbjct: 990 TCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSP 1049
Query: 202 -----------------------EGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLC 238
G+AG C+ N DDC CQ GA+C D V+ + CLC
Sbjct: 1050 DLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLC 1109
Query: 239 PSGYGGKTCELV--LPVPDPP 257
GY G+ CE+ LP P P
Sbjct: 1110 AEGYSGQLCEIPPHLPAPKSP 1130
Score = 148 bits (373), Expect = 9e-36
Identities = 90/258 (34%), Positives = 117/258 (45%), Gaps = 27/258 (10%)
Query: 18 GAPGQPVRA--DDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCE----RCVRMPGCQ 67
G P V+A D C S G C D C C G++G CE C P
Sbjct: 916 GPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCEN 975
Query: 68 HGTCHQ------PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
GTCH P+ C C +G+ G C + C + C NGG C+ DG G Y C C
Sbjct: 976 GGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHA-CANGGVCV-DGVGNYTCQCPL 1033
Query: 122 GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMR 181
+ G+ CE+ C +PC++ QC G C C+ G+ G C N DDC
Sbjct: 1034 QYEGKACEQLVDLCSPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDH 1090
Query: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTIN------LDDCASRPCQRGARCRDRVHDFD 235
C NGA C+D +N +SCLC EG++G+ C I C CQ GA C D+ +
Sbjct: 1091 RCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV 1150
Query: 236 CLCPSGYGGKTCELVLPV 253
C C G+GG CE +L V
Sbjct: 1151 CQCLPGFGGPECEKLLSV 1168
Score = 75.5 bits (184), Expect = 8e-14
Identities = 48/143 (33%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 37 HGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGWA 84
HG C P+ + C C+ GW GLHC++ P C HG C + C C G++
Sbjct: 1349 HGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYS 1408
Query: 85 GKFCDKDEHICTTQSPCQN----GGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGS 140
G C++ + PC+ G C G HCVC PGF G CE+++ E G
Sbjct: 1409 GALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES---ECRGD 1462
Query: 141 PCRNGGQCQDDQGFALNFTCRCL 163
P R+ Q Q +G+A+ T R L
Sbjct: 1463 PVRDFHQVQ--RGYAICQTTRPL 1483
Score = 52.0 bits (123), Expect = 9e-07
Identities = 43/126 (34%), Positives = 58/126 (46%), Gaps = 28/126 (22%)
Query: 117 CVCLPGFHGRDCERKA-GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
C C G+ G C++ A GPC G C +G QC AL+++C+C G+ GA C N
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCH--GHKCVHG-QCVPLD--ALSYSCQCQDGYSGALC--NQ 1414
Query: 176 DDCLMRPCANGATCLDGINRFS------CLCPEGFAGRFCTINLDDCASRPCQRGARCR- 228
L PC G CL G + S C+C GF+G C++ + CR
Sbjct: 1415 AGALAEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGEL------------CEQESECRG 1461
Query: 229 DRVHDF 234
D V DF
Sbjct: 1462 DPVRDF 1467
Score = 49.3 bits (116), Expect = 6e-06
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 12/97 (12%)
Query: 160 CRCLVGFVGARCEVNVDD-CLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCA 217
C C G+VG C+ D C C +G LD ++ +SC C +G++G C N
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALS-YSCQCQDGYSGALC--NQAGAL 1418
Query: 218 SRPCQRGARC------RDRVHDFDCLCPSGYGGKTCE 248
+ PC RG +C C+C G+ G+ CE
Sbjct: 1419 AEPC-RGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Score = 30.4 bits (67), Expect = 2.8
Identities = 16/60 (26%), Positives = 20/60 (33%), Gaps = 1/60 (1%)
Query: 198 CLCPEGFAGRFCTINLDD-CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
C C G+ G C D C C G + C C GY G C + +P
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 149 bits (377), Expect = 3e-36
Identities = 77/205 (37%), Positives = 104/205 (50%), Gaps = 19/205 (9%)
Query: 60 CVRMPGCQHG--------TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDG 111
C+ + C +G T + + C C SG+ G+ C D + C +Q PCQNGG C + G
Sbjct: 272 CLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQ-PCQNGGTCTH-G 329
Query: 112 GGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARC 171
+ C C GF G CE PC+ C++GGQCQ + G A+ C C G+ GA C
Sbjct: 330 INSFRCQCPAGFGGPTCETAQSPCDT--KECQHGGQCQVENGSAV---CVCQAGYTGAAC 384
Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTIN----LDDCASRPCQRGARC 227
E++VDDC PC NG +C+D + ++CLC E F G C D C S PC G C
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444
Query: 228 RDRVHDFDCLCPSGYGGKTCELVLP 252
D + C CP G+ G C +P
Sbjct: 445 VDADQGYVCECPEGFMGLDCRERVP 469
Score = 139 bits (350), Expect = 4e-33
Identities = 82/219 (37%), Positives = 101/219 (46%), Gaps = 23/219 (10%)
Query: 42 PDGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHI 94
P +C C G+ G C C P GTC ++C C +G+ G C+ +
Sbjct: 293 PSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSP 352
Query: 95 CTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF 154
C T+ CQ+GGQC + G CVC G+ G CE C PC NGG C D G
Sbjct: 353 CDTKE-CQHGGQCQVENGSAV-CVCQAGYTGAACEMDVDDCSP--DPCLNGGSCVDLVG- 407
Query: 155 ALNFTCRCLVGFVGARCEVN----VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
N+TC C F G RCE D CL PC NG TC+D + C CPEGF G C
Sbjct: 408 --NYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR 465
Query: 211 INL-DDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
+ DDC C+ G RC + C CP G+ G CE
Sbjct: 466 ERVPDDC---ECRNGGRCLG-ANTTLCQCPLGFFGLLCE 500
Score = 129 bits (325), Expect = 3e-30
Identities = 92/276 (33%), Positives = 119/276 (43%), Gaps = 37/276 (13%)
Query: 15 CILGAPGQPVRAD-DCSSHCDLAHGCCAPDGS-------CRCDPGWEGLHCERCVRMPGC 66
C G G+ +A+ DC ++ H +G+ CD G+ L +R+ C
Sbjct: 683 CQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYS-LSAPSRIRV--C 739
Query: 67 Q-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
Q HG +P QC+ + DE C +Q PC +GG C D Y C+C G+ G
Sbjct: 740 QPHGVWSEPPQCL----------EIDE--CRSQ-PCLHGGSCQ-DRVAGYLCLCSTGYEG 785
Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
CE + C PCRNGG C++ G + CRC GFVG CE VD C PC +
Sbjct: 786 AHCELERDECR--AHPCRNGGSCRNLPGA---YVCRCPAGFVGVHCETEVDACDSSPCQH 840
Query: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
G C G + C+CPE F G C D C S PC C C C GY G+
Sbjct: 841 GGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGE 900
Query: 246 TCELVLPVPDPPTTVDTPLGPTSAVVV---PATGPA 278
C L PPT + S V + P GPA
Sbjct: 901 DCAKEL---FPPTALKMERVEESGVSISWNPPNGPA 933
Score = 129 bits (324), Expect = 4e-30
Identities = 84/290 (28%), Positives = 111/290 (38%), Gaps = 74/290 (25%)
Query: 29 CSSHCDLAHGCCAPDGS---CRCDPGWEGLHCERCVRMPGCQHGTCHQ---------PWQ 76
CSS G C G C C + G HCE + C G CH ++
Sbjct: 584 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE-IGKPDSCASGPCHNGGTCFHYIGKYK 642
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA--GP 134
C C G++G+ C+ C +SPC NGG C D ++ C C G+ GR C+ + GP
Sbjct: 643 CDCPPGFSGRHCEIAPSPCF-RSPCVNGGTCE-DRDTDFFCHCQAGYMGRRCQAEVDCGP 700
Query: 135 --------------------------------------CEQAG----------------S 140
C+ G
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQ 760
Query: 141 PCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLC 200
PC +GG CQD + C C G+ GA CE+ D+C PC NG +C + + C C
Sbjct: 761 PCLHGGSCQDR---VAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRC 817
Query: 201 PEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
P GF G C +D C S PCQ G RC + C+CP + G CE V
Sbjct: 818 PAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETV 867
Score = 123 bits (308), Expect = 3e-28
Identities = 89/271 (32%), Positives = 116/271 (42%), Gaps = 36/271 (13%)
Query: 3 SGCRCLHLVC-LLCILGAPGQPVRA--------DDC-SSHCDLAHGCCAPDGS--CRCDP 50
+G C+ LV C+ P + +R D C S+ C C D C C
Sbjct: 398 NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPE 457
Query: 51 GWEGLHCERCVRMPG---CQHG-TC--HQPWQCICHSGWAGKFCDKDEHI--CTTQSPCQ 102
G+ GL C R+P C++G C C C G+ G C+ + C + C
Sbjct: 458 GFMGLDCRE--RVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCP 515
Query: 103 NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ--DDQGFALNFTC 160
+GG CM + GG Y CVC + PC+ PC NGG C DD ++TC
Sbjct: 516 DGGYCM-EHGGSYLCVCHTDHNAS--HSLPSPCDS--DPCFNGGSCDAHDD-----SYTC 565
Query: 161 RCLVGFVGARCE-VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINL-DDCAS 218
C GF G CE C PC NG TC + + C CP F GR C I D CAS
Sbjct: 566 ECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS 625
Query: 219 RPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
PC G C + + C CP G+ G+ CE+
Sbjct: 626 GPCHNGGTCFHYIGKYKCDCPPGFSGRHCEI 656
Score = 114 bits (285), Expect = 1e-25
Identities = 59/151 (39%), Positives = 78/151 (51%), Gaps = 12/151 (7%)
Query: 118 VCLPG---FHGRDCERKAGPCEQAGS------PCRNGGQCQDDQGFAL-NFTCRCLVGFV 167
V +PG F D + + G C S PC NGG+C DD ++TC CL GF
Sbjct: 245 VGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFT 304
Query: 168 GARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARC 227
G RC ++V++C +PC NG TC GIN F C CP GF G C C ++ CQ G +C
Sbjct: 305 GRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQC 364
Query: 228 RDRVHDFDCLCPSGYGGKTCELVLP--VPDP 256
+ C+C +GY G CE+ + PDP
Sbjct: 365 QVENGSAVCVCQAGYTGAACEMDVDDCSPDP 395
Score = 114 bits (284), Expect = 2e-25
Identities = 87/324 (26%), Positives = 120/324 (37%), Gaps = 88/324 (27%)
Query: 15 CILGAPGQPVRAD--DCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCERCVR---MPGC 66
C+ G G+ D +C+S G C + C+C G+ G CE C
Sbjct: 299 CLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKEC 358
Query: 67 QHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
QHG Q C+C +G+ G C+ D C+ PC NGG C+ D G Y C+C
Sbjct: 359 QHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPD-PCLNGGSCV-DLVGNYTCLCAEP 416
Query: 123 FHGRDCERKAGPCEQA--GSPCRNGGQCQD-DQGF------------------------- 154
F G CE P A +PC NGG C D DQG+
Sbjct: 417 FKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRN 476
Query: 155 ------ALNFTCRCLVGFVGARCEVNV--------------------------------- 175
A C+C +GF G CE +
Sbjct: 477 GGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHN 536
Query: 176 ------DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD-CASRPCQRGARCR 228
C PC NG +C + ++C CP GF G+ C C+S PC+ G C+
Sbjct: 537 ASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCK 596
Query: 229 DRVHDFDCLCPSGYGGKTCELVLP 252
+ ++ C CP + G+ CE+ P
Sbjct: 597 EAGGEYHCSCPYRFTGRHCEIGKP 620
Score = 45.1 bits (105), Expect = 1e-04
Identities = 21/47 (44%), Positives = 25/47 (53%), Gaps = 1/47 (2%)
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
+C PC NG TC+ G + SC C GF GR C + SRPC R
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPCTR 1355
Score = 44.3 bits (103), Expect = 2e-04
Identities = 24/61 (39%), Positives = 31/61 (50%), Gaps = 10/61 (16%)
Query: 97 TQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE----RKAGPC-----EQAGSPCRNGGQ 147
+++PCQNGG C+ G + C C PGF GR CE + + PC E P GG
Sbjct: 1312 SENPCQNGGTCV-PGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370
Query: 148 C 148
C
Sbjct: 1371 C 1371
Score = 35.8 bits (81), Expect = 0.066
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 6/64 (9%)
Query: 120 LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCL 179
LP +D G C + +PC+NGG C A +C C GF G RCE+ +
Sbjct: 1296 LPEHGSKDIGNVPGNCSE--NPCQNGGTCVPG---ADAHSCDCGPGFKGRRCELACIK-V 1349
Query: 180 MRPC 183
RPC
Sbjct: 1350 SRPC 1353
Score = 35.4 bits (80), Expect = 0.087
Identities = 15/45 (33%), Positives = 19/45 (42%)
Query: 215 DCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTT 259
+C+ PCQ G C C C G+ G+ CEL P T
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCT 1354
Score = 29.3 bits (64), Expect = 6.2
Identities = 18/67 (26%), Positives = 28/67 (41%), Gaps = 18/67 (26%)
Query: 28 DCSSHCDLAHGCCAPDG---SCRCDPGWEGLHCE-RCVRM--------------PGCQHG 69
+CS + G C P SC C PG++G CE C+++ P + G
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 70 TCHQPWQ 76
CH ++
Sbjct: 1370 VCHHVYK 1376
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 147 bits (371), Expect = 2e-35
Identities = 73/216 (33%), Positives = 104/216 (48%), Gaps = 15/216 (6%)
Query: 46 CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ--CICHSGWAGKFCDKDEHICT 96
C C GW G +C C P G CH+ P Q C+C + G+FC + ++C
Sbjct: 795 CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD 854
Query: 97 T-QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFA 155
+PC+N C+ HC+C F G++CE C C++ G C+D
Sbjct: 855 LLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS--CQDYGDCED---MV 909
Query: 156 LNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
NF C C GF G+ CE+ +++C PC N TC+D NRF C C + G FC ++++
Sbjct: 910 NNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNK 969
Query: 216 CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
C PC C R ++CLC GY G CE+ L
Sbjct: 970 CKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINL 1005
Score = 146 bits (369), Expect = 3e-35
Identities = 76/234 (32%), Positives = 116/234 (49%), Gaps = 25/234 (10%)
Query: 33 CDLAHGCCAPDGSCR----------CDPGWEGLHCERCVR---MPGCQ-HGTCHQP---W 75
CDL H C + +C C +EG +CE V+ CQ +G C +
Sbjct: 853 CDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNF 912
Query: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
+CIC G++G C+ + + C+++ PC+N G C+ D + C C P +HG CE C
Sbjct: 913 RCICRPGFSGSLCEIEINECSSE-PCKNNGTCV-DLTNRFFCNCEPEYHGPFCELDVNKC 970
Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
+ SPC + C + C C G+ G CE+N+D+CL PC + C+DGIN
Sbjct: 971 KI--SPCLDEENCVYRTD---GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH 1025
Query: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
++C C GF G C N +DC S PC G RC + ++++ C C + C++
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEYPCSCDADGTSTQCKI 1078
Score = 138 bits (348), Expect = 7e-33
Identities = 77/217 (35%), Positives = 108/217 (49%), Gaps = 21/217 (9%)
Query: 45 SCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---WQCICHSGWAGKFCDKDEHICTT 97
+C C PG+ G++CE C+ P G C + C C SG+ G C+ + + C +
Sbjct: 989 NCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLS 1048
Query: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALN 157
+PC +G +C + EY C C C+ K C PC N G CQ A
Sbjct: 1049 -NPCLHG-RCT-ELINEYPCSCDADGTSTQCKIKINDCTSI--PCMNEGFCQKS---AHG 1100
Query: 158 FTCRCLVGFVGARCEVNVDDCLMRP-----CANGATCLDGINR-FSCLCPEGFAGRFCTI 211
FTC C G+ GA CE ++D+C C NG C+DG F C C GF+G+FC I
Sbjct: 1101 FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEI 1160
Query: 212 NLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
N+++C+S PC GA C D ++ + C C G+ G CE
Sbjct: 1161 NINECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Score = 129 bits (325), Expect = 3e-30
Identities = 87/254 (34%), Positives = 113/254 (44%), Gaps = 26/254 (10%)
Query: 14 LCILGAPGQ--PVRADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHCER----CVRM 63
LC G G + D+C S L G C DG +C C G+ G HCE C+
Sbjct: 991 LCAPGYTGINCEINLDECLSEPCLHDGVCI-DGINHYTCDCKSGFFGTHCETNANDCLSN 1049
Query: 64 PGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
P C HG C + + C C + C + CT+ PC N G C G + C+C
Sbjct: 1050 P-CLHGRCTELINEYPCSCDADGTSTQCKIKINDCTS-IPCMNEGFCQKSAHG-FTCICP 1106
Query: 121 PGFHGRDCERKAGPC---EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD 177
G+ G CE+ C E C NGG C D G F CRCL GF G CE+N+++
Sbjct: 1107 RGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHT--FDCRCLPGFSGQFCEININE 1164
Query: 178 CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCL 237
C PC +GA C D IN + C C G++G C L +C C C + CL
Sbjct: 1165 CSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-ECIPNSCVH-ELCMENEPGSTCL 1222
Query: 238 CPSGYGGKTCELVL 251
C G+ TC + L
Sbjct: 1223 CTPGF--MTCSIGL 1234
Score = 114 bits (284), Expect = 2e-25
Identities = 79/278 (28%), Positives = 110/278 (39%), Gaps = 41/278 (14%)
Query: 3 SGCRCL--------HLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDG----SCRCDP 50
+GC CL +C L G DD + C H D C C
Sbjct: 537 NGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQ--HEAVCKDEINRPRCSCSL 594
Query: 51 GWEGLHCERCVRMPGCQ-------HGTCHQ-PWQCICHS--GWAGKFCDKDEHICTTQSP 100
+ G C V + C HG C C C + C+ D C + S
Sbjct: 595 SYIGRLC--VVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSAS- 651
Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFAL---- 156
C+NG + G + C+PGF G CE C A PC+NG C D G
Sbjct: 652 CKNGTTSTHLRGYFFR-KCVPGFKGTQCEIDIDEC--ASHPCKNGATCIDQPGNYFCQCV 708
Query: 157 -------NFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
F+C C G+VG RCE ++DDC++ C + +TC D + C+C + G FC
Sbjct: 709 PPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFC 768
Query: 210 TINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
++C PC+ + C D + C C SG+ G+ C
Sbjct: 769 EQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC 806
Score = 112 bits (281), Expect = 4e-25
Identities = 80/271 (29%), Positives = 115/271 (42%), Gaps = 42/271 (15%)
Query: 5 CRC-LHLVCLLCILGAPGQPVRADDC-SSHCDLAHGCC-APDGSCRCD--PGWEGLHCE- 58
C C L + LC+ V D C +H HG C A +C C +E CE
Sbjct: 590 CSCSLSYIGRLCV-------VNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEI 642
Query: 59 --RCVRMPGCQHGTCHQPWQCI----CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
+ C++GT + C G+ G C+ D C + PC+NG C+ D
Sbjct: 643 DTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH-PCKNGATCI-DQP 700
Query: 113 GEYHCVCLP--------------GFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
G Y C C+P G+ G CE+ C + C + C+D L++
Sbjct: 701 GNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCIL--NACEHNSTCKD---LHLSY 755
Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
C CL + G CE ++C M PC N +TC D + C C G+ G+ C+ +++C S
Sbjct: 756 QCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDS 815
Query: 219 RPCQRGARCRDRV--HDFDCLCPSGYGGKTC 247
PC G C + F CLCP Y G+ C
Sbjct: 816 DPCMNGGLCHESTIPGQFVCLCPPLYTGQFC 846
Score = 103 bits (256), Expect = 3e-22
Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 30/204 (14%)
Query: 66 CQH-GTC----HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC- 119
CQH C ++P +C C + G+ C + C G C+ ++C C
Sbjct: 575 CQHEAVCKDEINRP-RCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCL---ALSHNCNCS 630
Query: 120 -LPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDC 178
L + CE C+ A C+NG +G+ F +C+ GF G +CE+++D+C
Sbjct: 631 GLQRYERNICEIDTEDCKSAS--CKNGTTSTHLRGY---FFRKCVPGFKGTQCEIDIDEC 685
Query: 179 LMRPCANGATCLDG--------------INRFSCLCPEGFAGRFCTINLDDCASRPCQRG 224
PC NGATC+D ++ FSCLC G+ G C ++DDC C+
Sbjct: 686 ASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHN 745
Query: 225 ARCRDRVHDFDCLCPSGYGGKTCE 248
+ C+D + C+C S + G CE
Sbjct: 746 STCKDLHLSYQCVCLSDWEGNFCE 769
Score = 94.4 bits (233), Expect = 2e-19
Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)
Query: 22 QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71
+ + ++ CS H + SC C P + G +C+ C P +G+C
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235
Query: 72 -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
Q ++C+CH + GK C + H+C G C + C C F G
Sbjct: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288
Query: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
CE A PC R G C + +T C G E +V + + PC N
Sbjct: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343
Query: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
G C+ N C+C F C C S P + A C+ D+ C C SG+ K
Sbjct: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403
Query: 246 TCE 248
CE
Sbjct: 404 NCE 406
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/212 (30%), Positives = 87/212 (41%), Gaps = 42/212 (19%)
Query: 26 ADDCSSHCDLAHGCCAP---DGSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQP---W 75
A+DC S+ L HG C + C CD C+ C +P G C + +
Sbjct: 1043 ANDCLSNPCL-HGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGF 1101
Query: 76 QCICHSGWAGKFCDKDEHICTTQSP----CQNGGQCMYDGGGEYHCVCLPGFHGRDCERK 131
CIC G+ G +C+K C C NGG C+ G + C CLPGF G+ CE
Sbjct: 1102 TCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEIN 1161
Query: 132 AGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD--------------- 176
C + SPC +G C+D + C+C G+ G CE ++
Sbjct: 1162 INEC--SSSPCLHGADCEDHIN---GYVCKCQPGWSGHHCENELECIPNSCVHELCMENE 1216
Query: 177 ---DCLMRP----CANGATCLDGINRFSCLCP 201
CL P C+ G C D I R +CL P
Sbjct: 1217 PGSTCLCTPGFMTCSIGLLCGDEIRRITCLTP 1248
Score = 77.4 bits (189), Expect = 2e-14
Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Query: 53 EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
E L E C C + + C C ++GK+C + + + PC+N G C+
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233
Query: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168
Y CVC P F G++C G C+ C +G C + + +F C C F G
Sbjct: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288
Query: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
CEV+ C+ C + + ++ CP+G + + ++ + + PCQ G C
Sbjct: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
Query: 229 DRVHDFDCLCPSGYGGKTCELV 250
+D C+C + C+ +
Sbjct: 349 KISNDVMCICSPIFTDLLCKSI 370
Score = 65.9 bits (159), Expect = 6e-11
Identities = 30/90 (33%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDC-----ASRPCQRGAR 226
+ + C + C NG TC++ C C G+ G FCT + C C RGA
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 227 CRDRVHDFDCLCPSGYGGKTCELVLPVPDP 256
C H + C CP G G CE L + DP
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQALSISDP 2697
Score = 57.8 bits (138), Expect = 2e-08
Identities = 74/347 (21%), Positives = 102/347 (29%), Gaps = 141/347 (40%)
Query: 40 CAPDGSCRCDPGWEGLHCERC--------------------------VRMPGCQ------ 67
C D C C G+ +CE+ V +PGC
Sbjct: 388 CEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
Query: 68 ------------------HGTCHQ----PWQCICHSGWAGKFCDKDEHI----------C 95
HG C ++ + G+AG +K + + C
Sbjct: 448 LKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANC 507
Query: 96 T-----TQSPCQNGGQCMYDGGGEYH-----CVCLPGFHGRDCE-----RKAG------P 134
T P N C + G C CL ++ R AG
Sbjct: 508 TEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENT 567
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD------------------ 176
+ + C++ C+D+ C C + ++G C VNVD
Sbjct: 568 TDDQENECQHEAVCKDEIN---RPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALS 624
Query: 177 ---------------------DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD 215
DC C NG T F C GF G C I++D+
Sbjct: 625 HNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDE 684
Query: 216 CASRPCQRGARCRDR--------------VHDFDCLCPSGYGGKTCE 248
CAS PC+ GA C D+ V F CLC GY G CE
Sbjct: 685 CASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCE 731
Score = 54.3 bits (129), Expect = 2e-07
Identities = 32/106 (30%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 169 ARCEVNVDDCLMRPCA-----NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
AR N+++C + CA N TC+ C CP ++G+ C C + PC
Sbjct: 2325 ARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGN 2382
Query: 224 GARCRDRV-HDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTS 268
GA C + D CLCP G G C + + P + G TS
Sbjct: 2383 GATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTS 2428
Score = 53.5 bits (127), Expect = 3e-07
Identities = 27/69 (39%), Positives = 38/69 (55%), Gaps = 5/69 (7%)
Query: 142 CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCL-DGINRFSCLC 200
CRNGG+C + F+CRCL + G C +V CL C + + C+ D +SCLC
Sbjct: 2884 CRNGGECTVN---GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLC 2939
Query: 201 PEGFAGRFC 209
G+ GR+C
Sbjct: 2940 TLGWVGRYC 2948
Score = 48.1 bits (113), Expect = 1e-05
Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTC 160
C+NGG+C +G + C CLP + G C + C + C DQ F+ ++C
Sbjct: 2884 CRNGGECTVNGT-TFSCRCLPDWAGNTCNQSVSCLNNL---CLHQSLCIPDQSFS--YSC 2937
Query: 161 RCLVGFVGARCE 172
C +G+VG CE
Sbjct: 2938 LCTLGWVGRYCE 2949
Score = 46.2 bits (108), Expect = 5e-05
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)
Query: 168 GARCEVNVDDCL-----MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
GA+ NV DC C NG C FSC C +AG C ++ C + C
Sbjct: 2864 GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCL 2922
Query: 223 RGARC-RDRVHDFDCLCPSGYGGKTCE 248
+ C D+ + CLC G+ G+ CE
Sbjct: 2923 HQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 44.7 bits (104), Expect = 1e-04
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)
Query: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235
C+ CL +SC C F+G++C LD C+ +PC+ C ++ ++D
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
Query: 236 CLCPSGYGGKTCELVL 251
C+C + GK C ++
Sbjct: 242 CVCHPPFTGKNCSEII 257
Score = 42.7 bits (99), Expect = 5e-04
Identities = 24/75 (32%), Positives = 29/75 (38%), Gaps = 7/75 (9%)
Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSP---CRNGGQCQDDQGFALN 157
C NGG C+ G Y C C G+ G C C+ P C G C
Sbjct: 2619 CGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS---LPHG 2674
Query: 158 FTCRCLVGFVGARCE 172
+TC C +G G CE
Sbjct: 2675 YTCFCPLGTTGIYCE 2689
Score = 41.6 bits (96), Expect = 0.001
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 16/74 (21%)
Query: 38 GCCAPDG---SCRCDPGWEGLHCERCVRMPGCQHGTC-HQP---------WQCICHSGWA 84
G C +G SCRC P W G C + V C + C HQ + C+C GW
Sbjct: 2888 GECTVNGTTFSCRCLPDWAGNTCNQSV---SCLNNLCLHQSLCIPDQSFSYSCLCTLGWV 2944
Query: 85 GKFCDKDEHICTTQ 98
G++C+ T +
Sbjct: 2945 GRYCENKTSFSTAK 2958
Score = 40.0 bits (92), Expect = 0.004
Identities = 21/75 (28%), Positives = 31/75 (41%), Gaps = 11/75 (14%)
Query: 66 CQHGTCHQPWQCI---------CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C + TC +C C WAG C++ + + C + C+ D Y
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS--VSCLNNLCLHQSLCIPDQSFSYS 2936
Query: 117 CVCLPGFHGRDCERK 131
C+C G+ GR CE K
Sbjct: 2937 CLCTLGWVGRYCENK 2951
Score = 39.3 bits (90), Expect = 0.006
Identities = 25/89 (28%), Positives = 34/89 (38%), Gaps = 13/89 (14%)
Query: 49 DPGWEGLHCERCVRMPGCQHGTCHQPWQCI---------CHSGWAGKFCDKDEHICTTQS 99
D G + E C +P C H C CI C ++GK C + +
Sbjct: 2323 DEARHGKNIENC-HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC---QFASCENN 2378
Query: 100 PCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
PC NG C+ G + C+C G G C
Sbjct: 2379 PCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407
Score = 38.1 bits (87), Expect = 0.013
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 8/82 (9%)
Query: 56 HCERCVRMPGCQHGTCHQPWQ---CICHSGWAGKFCDKDEHICTTQSP----CQNGGQCM 108
H C M GTC + C C +GW G FC + C + C G C+
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669
Query: 109 YDGGGEYHCVCLPGFHGRDCER 130
G Y C C G G CE+
Sbjct: 2670 SLPHG-YTCFCPLGTTGIYCEQ 2690
Score = 34.7 bits (78), Expect = 0.15
Identities = 17/37 (45%), Positives = 17/37 (45%), Gaps = 5/37 (13%)
Query: 178 CLMRPCANGATC-----LDGINRFSCLCPEGFAGRFC 209
C C NG TC GI F C CP F GRFC
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139
Score = 31.2 bits (69), Expect = 1.6
Identities = 16/40 (40%), Positives = 19/40 (47%), Gaps = 4/40 (10%)
Query: 98 QSPCQNGGQC----MYDGGGEYHCVCLPGFHGRDCERKAG 133
Q C NGG C + G + C C F GR CE+ AG
Sbjct: 2105 QDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG 2144
Score = 31.2 bits (69), Expect = 1.6
Identities = 17/68 (25%), Positives = 24/68 (35%), Gaps = 15/68 (22%)
Query: 38 GCCAPDGS---CRCDPGWEGLHCERCVRMPGCQHGTCH------------QPWQCICHSG 82
G C G+ C C GW+G C V +H H + C C G
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG 2682
Query: 83 WAGKFCDK 90
G +C++
Sbjct: 2683 TTGIYCEQ 2690
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 138 bits (348), Expect = 7e-33
Identities = 79/252 (31%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 25 RADDCSSHCDLAHGCCAPDG----SCRCDPGWEGLHC----ERCVRMPGCQHG-TCH--- 72
+ + C S +G C D C C ++G C C++ P CQHG TCH
Sbjct: 916 KCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSD 974
Query: 73 ---QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
+ C C G+ G+ C+ + C + C+N C+ DG Y C+C P + G C+
Sbjct: 975 SHKDGFSCSCPLGFEGQRCEINPDDCE-DNDCENNATCV-DGINNYVCICPPNYTGELCD 1032
Query: 130 RKAGPCEQAGSPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
C + C++ +C D+GF+ C C+ G+ G CE + DDC+ C +GA
Sbjct: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFS----CECVPGYSGKLCETDNDDCVAHKCRHGAQ 1088
Query: 189 CLDGINRFSCLCPEGFAGRFC-------TINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
C+D IN ++C CP+GF+G FC + C CQ GA+C + C CP G
Sbjct: 1089 CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPG 1148
Query: 242 YGGKTCELVLPV 253
+ G CE ++ V
Sbjct: 1149 FAGPRCEKLITV 1160
Score = 67.0 bits (162), Expect = 3e-11
Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 13/119 (10%)
Query: 29 CSSHCDLAHGCCAPDGS----CRCDPGWEGLHCERCVRMP----GCQHGTC---HQPWQC 77
C S HG C C C PGW G C++ R P C HG C + C
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
Query: 78 ICHSGWAGKFCDKDEHICTTQSPCQ-NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
C G+ G CD S + + GQC GE +C+C PGF G C+++ PC
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
Score = 48.1 bits (113), Expect = 1e-05
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 160 CRCLVGFVGARCEVNV-DDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDD--- 215
C C G+ G C+ D CL C +G G + + C C EG+ G C D
Sbjct: 1353 CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCKCAEGYGGDLCDNKNDSANA 1411
Query: 216 CASRPCQRG-ARCRDRVHDFDCLCPSGYGGKTCE 248
C++ C G D+ + CLC G+ G+ C+
Sbjct: 1412 CSAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQ 1444
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 135 bits (339), Expect = 8e-32
Identities = 74/206 (35%), Positives = 93/206 (45%), Gaps = 14/206 (6%)
Query: 48 CDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQC 107
C PG + C C + C C + G FC +E+ + PCQN C
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFC--EEYDACQRKPCQNNASC 364
Query: 108 M----YDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCL 163
+ G + CVCLPG+ G C+ K C PCRNG C FTC+C
Sbjct: 365 IDANEKQDGSNFTCVCLPGYTGELCQSKIDYC--ILDPCRNGATCISSLS---GFTCQCP 419
Query: 164 VGFVGARCEVNVDDCLMRPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQ 222
G+ G+ CE VD C PC N TC +DG++ F+C C GF G C +D CA PC
Sbjct: 420 EGYFGSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCA 478
Query: 223 RGARCRDRVHDFDCLCPSGYGGKTCE 248
G CR + CLC GY G CE
Sbjct: 479 HGT-CRSVGTSYKCLCDPGYHGLYCE 503
Score = 130 bits (326), Expect = 3e-30
Identities = 80/293 (27%), Positives = 111/293 (37%), Gaps = 93/293 (31%)
Query: 45 SCRCDPGWEGLHCER---CVRMPGCQHGTCHQP--------WQCICHSGWAGKFCDKDEH 93
SC C+ + G CE C R P + +C + C+C G+ G+ C
Sbjct: 335 SCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKID 394
Query: 94 ICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQG 153
C PC+NG C+ G + C C G+ G CE K PC A SPC+N G C D
Sbjct: 395 YCILD-PCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPC--ASSPCQNNGTCYVD-- 448
Query: 154 FALNFTCRCLVGFVGARCEVNVD------------------------------------- 176
++FTC C GF G C +D
Sbjct: 449 -GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYN 507
Query: 177 DCLMRPCANGATCLDGINRF--------------------------------------SC 198
+CL PC N ATC D +N + +C
Sbjct: 508 ECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTC 567
Query: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
+C GF G C I++++C S PC G C D+ + ++C CP G+ G CE+ L
Sbjct: 568 ICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
Score = 63.5 bits (153), Expect = 3e-10
Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 16/113 (14%)
Query: 178 CLMRPCANGATCLD------------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
C +PC NG C G +SC CP G +G C + D CAS PC G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 226 RCRDRVHDFD---CLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPAT 275
D C+C GY G CE LP P T + P VPAT
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALP-SLPATGWTESMAPRQLQPVPAT 159
Score = 54.7 bits (130), Expect = 1e-07
Identities = 31/89 (34%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 133 GPCEQAGSPCRNGGQCQ-----DDQGFAL----NFTCRCLVGFVGARCEVNVDDCLMRPC 183
GPC A PCRNGG C D Q A ++C C G GA C++ D C PC
Sbjct: 46 GPC--AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103
Query: 184 ANG---ATCLDGINRFSCLCPEGFAGRFC 209
+G ++ + + C+C EG+ G C
Sbjct: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 14/89 (15%)
Query: 95 CTTQSPCQNGGQCMYD-----------GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCR 143
C Q PC+NGG C G Y C C G G +C+ A PC A +PC
Sbjct: 48 CAAQ-PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC--ASNPCH 104
Query: 144 NGGQCQDDQGFALNFTCRCLVGFVGARCE 172
+G + + C C G+ G CE
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 36.2 bits (82), Expect = 0.051
Identities = 34/129 (26%), Positives = 48/129 (37%), Gaps = 19/129 (14%)
Query: 10 LVCLLCILGAP------GQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
L LL +LGA PV A S+ A C G C P + H
Sbjct: 17 LALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQH-----PA 71
Query: 64 PGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGE--YHCVCLP 121
P + G + C C +G +G C C + +PC +G Y C+C
Sbjct: 72 PAGEPG-----YSCTCPAGISGANCQLVADPCAS-NPCHHGNCSSSSSSSSDGYLCICNE 125
Query: 122 GFHGRDCER 130
G+ G +CE+
Sbjct: 126 GYEGPNCEQ 134
Score = 30.4 bits (67), Expect = 2.8
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 9/67 (13%)
Query: 2 PSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGS-------CRCDPGWEG 54
P+G C I GA Q V AD C+S+ HG C+ S C C+ G+EG
Sbjct: 72 PAGEPGYSCTCPAGISGANCQLV-ADPCASN-PCHHGNCSSSSSSSSDGYLCICNEGYEG 129
Query: 55 LHCERCV 61
+CE+ +
Sbjct: 130 PNCEQAL 136
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 126 bits (316), Expect = 4e-29
Identities = 99/352 (28%), Positives = 135/352 (38%), Gaps = 102/352 (28%)
Query: 29 CSSHCDLAH-GCCAPD-GSCRCDPGWEGLHC----------ERCVRMPGCQHGTCHQP-- 74
C++ C AH C+P G+C C PGW G HC E C C H P
Sbjct: 490 CNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVH 549
Query: 75 WQCICHSGWAGKFCDKDEHI----------CTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
+C C +GW G C H+ C+ C+NGG C+ + G +CVC PGF
Sbjct: 550 GRCQCQAGWMGARC----HLSCPEGLWGVNCSNTCTCKNGGTCLPENG---NCVCAPGFR 602
Query: 125 GRDCERKAGPCEQ----AGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV----- 175
G C+R P C N C G TC CL G+ G C
Sbjct: 603 GPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG-----TCYCLAGWTGPDCSQPCPPGHW 657
Query: 176 -DDCLMR-PCANGATC--LDGINRFSCLCPEGFAGRFCTINLDDC--------ASRPCQR 223
++C C +G TC DG SC+CP G+ G C L+ C S+PCQ
Sbjct: 658 GENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHC---LEGCPLGTFGANCSQPCQC 710
Query: 224 GARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAG 283
G + C+CP G+ G C + + P V+P T A +S G
Sbjct: 711 GPGEKCHPETGACVCPPGHSGAPCRIGIQEP--------------FTVMPTTPVAYNSLG 756
Query: 284 AGLLRISVKEVVRRQEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRG 335
A ++ + V G+L ALV + + R W++G
Sbjct: 757 A----------------------VIGIAVLGSLVVALV--ALFIGYRHWQKG 784
Score = 93.2 bits (230), Expect = 3e-19
Identities = 81/297 (27%), Positives = 106/297 (35%), Gaps = 64/297 (21%)
Query: 1 MPSGCRCLH-LVCLLCILGAPGQPVRADDCSSHCDLAHG--CCAPDGSCRCDPGW----- 52
M C CL L C P Q C HC HG C A G C+C PG+
Sbjct: 376 MNGECSCLPGWAGLHCNESCP-QDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHC 434
Query: 53 --------EGLHCE-RCVRMPGCQHGTCHQP--WQCICHSGWAGKFCDKD------EHIC 95
G++C RC C++ P +C+C GW C C
Sbjct: 435 ASLCPPDTYGVNCSARC----SCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSC 490
Query: 96 TTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF- 154
C + C G C C PG+HG C+ P Q G C + C G
Sbjct: 491 NASCQCAHEAVCSPQTGA---CTCTPGWHGAHCQLPC-PKGQFGEGCASRCDCDHSDGCD 546
Query: 155 ALNFTCRCLVGFVGARCEVNVDDCLMR-------PCANGATCLDGINRFSCLCPEGFAGR 207
++ C+C G++GARC ++ + L C NG TCL +C+C GF G
Sbjct: 547 PVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLP--ENGNCVCAPGFRGP 604
Query: 208 FCTINLDDCASRPCQRG------ARCRDRVHDF------DCLCPSGYGGKTCELVLP 252
C R CQ G C+ H F C C +G+ G C P
Sbjct: 605 SC--------QRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCP 653
Score = 84.0 bits (206), Expect = 2e-16
Identities = 91/308 (29%), Positives = 107/308 (34%), Gaps = 74/308 (24%)
Query: 7 CLHLVCLLCILG---APGQPV-----RADDCSSHC---------DLAHGC-----CAP-D 43
C+ L C+ G AP Q R DDCSS C D C C P
Sbjct: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS 160
Query: 44 GSCRCDPGWEGLHC-ERCVRM---PGCQHGT-CH------QPWQCICHSGWAGKFCD--- 89
G C C G + +C + C P CQ CH Q C C + G CD
Sbjct: 161 GVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSC 220
Query: 90 ---KDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC-----ERKAGPCEQAGSP 141
C + CQNGG G C C PG+ G C E GP
Sbjct: 221 SQGTSGFFCPSTHSCQNGGVFQTPQGS---CSCPPGWMGTICSLPCPEGFHGPNCSQECR 277
Query: 142 CRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM----RPCANGATCLDGINRF- 196
C NGG C G CRC G+ G RC ++C + + CA C F
Sbjct: 278 CHNGGLCDRFTG-----QCRCAPGYTGDRCR---EECPVGRFGQDCAETCDCAPDARCFP 329
Query: 197 ---SCLCPEGFAGRFCTINL--DDCASRPCQRGARCRDRVHDF-------DCLCPSGYGG 244
+CLC GF G CT L D CQ C DR H +C C G+ G
Sbjct: 330 ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC-DREHSLSCHPMNGECSCLPGWAG 388
Query: 245 KTCELVLP 252
C P
Sbjct: 389 LHCNESCP 396
Score = 65.1 bits (157), Expect = 1e-10
Identities = 59/215 (27%), Positives = 79/215 (36%), Gaps = 42/215 (19%)
Query: 66 CQHGTCHQPWQCICHSGWAGKFCDKD------EHICTTQSPCQNGGQCMYDGG------- 112
C HG C P QC C GW G C + C C N C G
Sbjct: 109 CVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSG 168
Query: 113 -GEYHCV--CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGA 169
+C+ C PG++G C+ + C+ G+PC D Q A C C G
Sbjct: 169 LQPPNCLQPCTPGYYGPACQFR---CQCHGAPC-------DPQTGA----CFCPAERTGP 214
Query: 170 RCEVNVDDCLMR-PCANGATCLDG----INRFSCLCPEGFAGRFCTINLDDCASRP-CQR 223
C+V+ C + +C +G + SC CP G+ G C++ + P C +
Sbjct: 215 SCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQ 274
Query: 224 GARCR-----DRVHDFDCLCPSGYGGKTCELVLPV 253
RC DR C C GY G C PV
Sbjct: 275 ECRCHNGGLCDRFTG-QCRCAPGYTGDRCREECPV 308
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 125 bits (313), Expect = 8e-29
Identities = 70/209 (33%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 44 GSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCI-----------CHSGWAGKFCD-KD 91
G C+C G+ G +C+ R P C+ C C+ C SG+ G+ C
Sbjct: 10 GYCKCPEGFLGEYCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
Query: 92 EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD 151
H C PC NGG C Y C C GF G++C+ C PC NG C
Sbjct: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC--LSHPCANGSTCTT- 122
Query: 152 QGFALNFTCRCLVGFVGARCEVNVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
A F+C+CL GF G +CE +V++C + C +G TCL+ + C C +GF G++C
Sbjct: 123 --VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
Query: 211 INLDDCASRPCQRGARCRDR-VHDFDCLC 238
CA PC G CR F+C C
Sbjct: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
Score = 118 bits (296), Expect = 8e-27
Identities = 66/185 (35%), Positives = 90/185 (48%), Gaps = 10/185 (5%)
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG-GEYHCVCLPGFHGRDCERKAG-P 134
C C G+ G++C + ++ CQNGG C+ G+ C C GF G DC+ P
Sbjct: 12 CKCPEGFLGEYCQHRDPC--EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
Query: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
C PC NGG C + C C VGF G C+ D CL PCANG+TC N
Sbjct: 70 CF-VSRPCLNGGTCH--MLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
Query: 195 RFSCLCPEGFAGRFCTINLDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE-LVLP 252
+FSC C GF G+ C ++++C CQ G C + + C C G+ G+ C+ L +P
Sbjct: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
Query: 253 VPDPP 257
P
Sbjct: 186 CAPSP 190
Score = 96.3 bits (238), Expect = 4e-20
Identities = 53/145 (36%), Positives = 72/145 (49%), Gaps = 8/145 (5%)
Query: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
C+ G +C C GF G C+ + PCE+ + C+NGG C Q TCRC GF
Sbjct: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEK--NRCQNGGTCV-AQAMLGKATCRCASGF 57
Query: 167 VGARCEVNVD-DCLM-RPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
G C+ + C + RPC NG TC + + + C C GF G+ C D C S PC
Sbjct: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCAN 116
Query: 224 GARCRDRVHDFDCLCPSGYGGKTCE 248
G+ C + F C C +G+ G+ CE
Sbjct: 117 GSTCTTVANQFSCKCLTGFTGQKCE 141
Score = 65.9 bits (159), Expect = 6e-11
Identities = 45/119 (37%), Positives = 58/119 (48%), Gaps = 13/119 (10%)
Query: 15 CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
C +G G+ + D C SH C C A SC+C G+ G CE V +PG C
Sbjct: 94 CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 153
Query: 67 QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
QHG TC +QC C G+ G++CD ++ SPC NGG C G + C CLP
Sbjct: 154 QHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 121 bits (304), Expect = 9e-28
Identities = 61/179 (34%), Positives = 83/179 (46%), Gaps = 26/179 (14%)
Query: 92 EHICTTQSPCQNGGQCMY---------------------DGGGEYHCVCLPGFHGRDCER 130
+H PCQNGG C+ + + C CLPG+ G CE
Sbjct: 3802 DHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEI 3861
Query: 131 KAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCL 190
C SPC +GG C + G F+C C GF G CE ++++CL PC NGA C
Sbjct: 3862 DIDEC--LPSPCHSGGTCHNLVG---GFSCSCPDGFTGRACERDINECLQSPCKNGAICQ 3916
Query: 191 DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
+ F+C+C G+ G+ C +++ C PC G C+ V + C CP G GK CEL
Sbjct: 3917 NFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCEL 3975
Score = 118 bits (296), Expect = 8e-27
Identities = 59/140 (42%), Positives = 77/140 (55%), Gaps = 7/140 (5%)
Query: 73 QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
QP+ C C G+AG +C+ D C SPC +GG C GG + C C GF GR CER
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDIDECLP-SPCHSGGTCHNLVGG-FSCSCPDGFTGRACERDI 3901
Query: 133 GPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
C Q SPC+NG CQ+ G +F C C G+ G CE +V+ C PC NG +C G
Sbjct: 3902 NECLQ--SPCKNGAICQNFPG---SFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSG 3956
Query: 193 INRFSCLCPEGFAGRFCTIN 212
++ + C CP G G+ C +N
Sbjct: 3957 VDSYYCHCPFGVFGKHCELN 3976
Score = 96.3 bits (238), Expect = 4e-20
Identities = 51/136 (37%), Positives = 70/136 (51%), Gaps = 14/136 (10%)
Query: 46 CRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTTQ 98
C+C PG+ G CE C+ P GTCH + C C G+ G+ C++D + C Q
Sbjct: 3848 CKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC-LQ 3906
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
SPC+NG C + G ++CVC G+ G+ CE CE +PC NGG CQ ++
Sbjct: 3907 SPCKNGAICQ-NFPGSFNCVCKTGYTGKMCESSVNYCE--CNPCFNGGSCQSGVD---SY 3960
Query: 159 TCRCLVGFVGARCEVN 174
C C G G CE+N
Sbjct: 3961 YCHCPFGVFGKHCELN 3976
Score = 72.4 bits (176), Expect = 6e-13
Identities = 41/131 (31%), Positives = 57/131 (43%), Gaps = 25/131 (19%)
Query: 143 RNGGQCQDDQGFALNFTC--RCLVGFVGARCE-VNVDDCLMRPCANGATCL--------- 190
RN Q + G A F L+ G + E V+ D C+ PC NG +CL
Sbjct: 3768 RNHNQYVNPSGVATFFESIKEILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVL 3827
Query: 191 -------------DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCL 237
+ + F C C G+AG +C I++D+C PC G C + V F C
Sbjct: 3828 KSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCS 3887
Query: 238 CPSGYGGKTCE 248
CP G+ G+ CE
Sbjct: 3888 CPDGFTGRACE 3898
Score = 65.5 bits (158), Expect = 8e-11
Identities = 43/128 (33%), Positives = 60/128 (46%), Gaps = 16/128 (12%)
Query: 15 CILGAPGQ--PVRADDC-SSHCDLAHGCCAPDG--SCRCDPGWEGLHCER----CVRMPG 65
C+ G G + D+C S C C G SC C G+ G CER C++ P
Sbjct: 3850 CLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP- 3908
Query: 66 CQHGTCHQ----PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
C++G Q + C+C +G+ GK C+ + C +PC NGG C G Y+C C
Sbjct: 3909 CKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCEC-NPCFNGGSCQ-SGVDSYYCHCPF 3966
Query: 122 GFHGRDCE 129
G G+ CE
Sbjct: 3967 GVFGKHCE 3974
Score = 55.5 bits (132), Expect = 8e-08
Identities = 34/104 (32%), Positives = 43/104 (41%), Gaps = 16/104 (15%)
Query: 178 CLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHD-FDC 236
C PC C++ + C+ P DCAS PCQ G C +H F C
Sbjct: 4404 CASNPCWGDLLCINQWYAYRCVPP------------GDCASHPCQNGGSCEPGLHSGFTC 4451
Query: 237 LCPSGYGGKTCELV---LPVPDPPTTVDTPLGPTSAVVVPATGP 277
CP + G+TCE+V L V P V P V V + GP
Sbjct: 4452 SCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAGHVCVLSQGP 4495
Score = 44.7 bits (104), Expect = 1e-04
Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 3/68 (4%)
Query: 162 CLVGFVGARCEVNVDDCLMRPCANGATCLDGINR-FSCLCPEGFAGRFCTINLDDCASRP 220
C+ + RC V DC PC NG +C G++ F+C CP+ GR C + + C
Sbjct: 4415 CINQWYAYRC-VPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEM-VVACLGVL 4472
Query: 221 CQRGARCR 228
C +G C+
Sbjct: 4473 CPQGKVCK 4480
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDG 192
P + A PC+NGG C+ G FTC C G CE+ V CL C G C G
Sbjct: 4427 PGDCASHPCQNGGSCEP--GLHSGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAG 4482
Score = 39.3 bits (90), Expect = 0.006
Identities = 23/62 (37%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 73 QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
+P Q + G + C + E CT +SPCQ+GG CM D C C G G+ CE+
Sbjct: 4145 EPSQALAAQGILDQ-CPRLEGACT-RSPCQHGGTCM-DYWSWQQCHCKEGLTGKYCEKSV 4201
Query: 133 GP 134
P
Sbjct: 4202 TP 4203
Score = 37.0 bits (84), Expect = 0.030
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 178 CLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
C PC +G TC+D + C C EG G++C
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYC 4197
Score = 35.0 bits (79), Expect = 0.11
Identities = 18/48 (37%), Positives = 23/48 (47%), Gaps = 5/48 (10%)
Query: 128 CERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNV 175
C R G C + SPC++GG C D + C C G G CE +V
Sbjct: 4159 CPRLEGACTR--SPCQHGGTCMDYWSWQ---QCHCKEGLTGKYCEKSV 4201
Score = 33.1 bits (74), Expect = 0.43
Identities = 14/33 (42%), Positives = 14/33 (42%)
Query: 216 CASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C PCQ G C D C C G GK CE
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198
Score = 32.7 bits (73), Expect = 0.56
Identities = 34/125 (27%), Positives = 39/125 (31%), Gaps = 36/125 (28%)
Query: 38 GCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTT 97
GC P+ C +P W L C + C P C H
Sbjct: 4397 GCRGPN-ICASNPCWGDLLC-----INQWYAYRCVPPGDCASH----------------- 4433
Query: 98 QSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCER---------KAGPCEQAGSPCRNGGQC 148
PCQNGG C + C C GR CE G +AGSP G C
Sbjct: 4434 --PCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPA--GHVC 4489
Query: 149 QDDQG 153
QG
Sbjct: 4490 VLSQG 4494
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 121 bits (303), Expect = 1e-27
Identities = 62/178 (34%), Positives = 82/178 (46%), Gaps = 6/178 (3%)
Query: 99 SPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNF 158
+PCQNGG C G Y+C C + G CE PC + PC GG C D G F
Sbjct: 4020 NPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPC--SSKPCLYGGTCVVDNG---GF 4074
Query: 159 TCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCAS 218
C+C + G RC+++ C PC NG TC D ++ C C GF G C ++D+C+
Sbjct: 4075 VCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSG 4133
Query: 219 RPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATG 276
PC GA C + + C C Y G+ CE P T + L +VV G
Sbjct: 4134 NPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAG 4191
Score = 90.5 bits (223), Expect = 2e-18
Identities = 52/157 (33%), Positives = 79/157 (50%), Gaps = 14/157 (8%)
Query: 58 ERCVRMPGCQHGTCHQP-----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
E C P CQ+G P + C C + + G C+ + C+++ PC GG C+ D G
Sbjct: 4015 EDCASNP-CQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSK-PCLYGGTCVVDNG 4072
Query: 113 GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
G + C C + G+ C+ + C+ PC+NGG C D A+ C+C GF G RC+
Sbjct: 4073 G-FVCQCRGLYTGQRCQ-LSPYCKD--EPCKNGGTCFDSLDGAV---CQCDSGFRGERCQ 4125
Query: 173 VNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
++D+C PC +GA C + + C C + GR C
Sbjct: 4126 SDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHC 4162
Score = 71.6 bits (174), Expect = 1e-12
Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 19/157 (12%)
Query: 27 DDCSSHCDLAHGCCAPDGS----CRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPW 75
+DC+S+ G C P + C+C + G HCE C P GTC + +
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGF 4074
Query: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
C C + G+ C + PC+NGG C +D C C GF G C+ C
Sbjct: 4075 VCQCRGLYTGQRCQLSPY--CKDEPCKNGGTC-FDSLDGAVCQCDSGFRGERCQSDIDEC 4131
Query: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
+G+PC +G C++ G ++ C C + G CE
Sbjct: 4132 --SGNPCLHGALCENTHG---SYHCNCSHEYRGRHCE 4163
Score = 55.5 bits (132), Expect = 8e-08
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 1/83 (1%)
Query: 176 DDCLMRPCANGATCLDG-INRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
+DC PC NG C + C C + G C I+++ C+S+PC G C F
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGF 4074
Query: 235 DCLCPSGYGGKTCELVLPVPDPP 257
C C Y G+ C+L D P
Sbjct: 4075 VCQCRGLYTGQRCQLSPYCKDEP 4097
Score = 32.0 bits (71), Expect = 0.96
Identities = 19/56 (33%), Positives = 24/56 (42%), Gaps = 6/56 (10%)
Query: 72 HQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH-CVCLPGFHGR 126
H+ C+C G C H C PC G +C+ D E H CVC G G+
Sbjct: 3775 HRAAVCLCKEGR----CPPVHHGCE-DDPCPEGSECVSDPWEEKHTCVCPSGRFGQ 3825
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 114 bits (286), Expect = 1e-25
Identities = 79/246 (32%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 4 GCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRM 63
G CL C G G C+ HC+ C PD C+C PGW G C +
Sbjct: 1369 GGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPD-ICQCKPGWYGPTCSTALCD 1427
Query: 64 PGCQH-GTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
P C + G+C++P C+C +G+ G+ C PC+NGG CM + CVC G
Sbjct: 1428 PVCLNGGSCNKPNTCLCPNGFFGEHCQN----AFCHPPCKNGGHCMRNN----VCVCREG 1479
Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
+ GR ++ C+ C NGG+C TC C G+ G RC N CL +
Sbjct: 1480 YTGRRFQKSI--CDPT---CMNGGKCVGPS------TCSCPSGWSGKRC--NTPICLQK- 1525
Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
C NG C I C CP + G C I + + C G RC + C C + Y
Sbjct: 1526 CKNGGEC---IAPSICHCPSSWEGVRCQIPI---CNPKCLYGGRC---IFPNVCSCRTEY 1576
Query: 243 GGKTCE 248
G CE
Sbjct: 1577 SGVKCE 1582
Score = 108 bits (271), Expect = 6e-24
Identities = 73/219 (33%), Positives = 96/219 (43%), Gaps = 35/219 (15%)
Query: 29 CSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQ-HGTCHQPWQCICHSGWAGKF 87
C C + C AP+ C+C PG+ G +C+ + P C+ HG C +P C C G G
Sbjct: 1298 CKYPCGKSRECVAPN-ICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGAT 1356
Query: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQ 147
CD +EH PCQ+GG C+ C C GF G CE C NGGQ
Sbjct: 1357 CD-EEH---CNPPCQHGGTCLAGN----LCTCPYGFVGPRCETMV-----CNRHCENGGQ 1403
Query: 148 CQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGR 207
C C+C G+ G C + D + C NG +C +CLCP GF G
Sbjct: 1404 CLTPD------ICQCKPGWYGPTCSTALCDPV---CLNGGSC---NKPNTCLCPNGFFGE 1451
Query: 208 FCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGK 245
C + PC+ G C R+ V C+C GY G+
Sbjct: 1452 HCQ---NAFCHPPCKNGGHCMRNNV----CVCREGYTGR 1483
Score = 106 bits (265), Expect = 3e-23
Identities = 76/234 (32%), Positives = 96/234 (41%), Gaps = 33/234 (14%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQH-GTCHQ 73
C G G + C C HG C C+C PG G C+ P CQH GTC
Sbjct: 1316 CKPGYIGSNCQTALCDPDCK-NHGKCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTCLA 1374
Query: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG 133
C C G+ G C + +C C+NGGQC+ C C PG++G C
Sbjct: 1375 GNLCTCPYGFVGPRC--ETMVCNRH--CENGGQCLTPD----ICQCKPGWYGPTC--STA 1424
Query: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
C+ C NGG C TC C GF G C+ + PC NG C+
Sbjct: 1425 LCDPV---CLNGGSCNKPN------TCLCPNGFFGEHCQ---NAFCHPPCKNGGHCM--- 1469
Query: 194 NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
C+C EG+ GR ++ D C G +C V C CPSG+ GK C
Sbjct: 1470 RNNVCVCREGYTGRRFQKSICD---PTCMNGGKC---VGPSTCSCPSGWSGKRC 1517
Score = 57.4 bits (137), Expect = 2e-08
Identities = 42/155 (27%), Positives = 58/155 (37%), Gaps = 45/155 (29%)
Query: 142 CRNGGQCQDDQGFALN---FTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
C NGG C D+ F+ + C CL GF G+ CEV++ C PC G + + G + +SC
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLG-SYISGFHSYSC 1241
Query: 199 LCP------EGFAGRFCT-----------INLDD---------------------CASRP 220
CP F +F T +N ++ P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301
Query: 221 CQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPD 255
C + C V C C GY G C+ L PD
Sbjct: 1302 CGKSREC---VAPNICKCKPGYIGSNCQTALCDPD 1333
Score = 55.8 bits (133), Expect = 6e-08
Identities = 50/187 (26%), Positives = 66/187 (35%), Gaps = 50/187 (26%)
Query: 101 CQNGGQCMYD-----GGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGG--------- 146
C NGG C+ D G G Y CVCLPGFHG CE C+ +PC G
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQ--SNPCGLGSYISGFHSYS 1240
Query: 147 -----QCQDDQGFALNFTCRCLV---------------GFVGARCEV-----NVDDCLMR 181
+ + + F FT + +V G + V N
Sbjct: 1241 CDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKY 1300
Query: 182 PCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSG 241
PC C + C C G+ G C L D C+ +C + C C G
Sbjct: 1301 PCGKSREC---VAPNICKCKPGYIGSNCQTALCD---PDCKNHGKC---IKPNICQCLPG 1351
Query: 242 YGGKTCE 248
+GG TC+
Sbjct: 1352 HGGATCD 1358
Score = 48.1 bits (113), Expect = 1e-05
Identities = 57/243 (23%), Positives = 83/243 (34%), Gaps = 54/243 (22%)
Query: 33 CD-LAHGCCAPDGS---------CRCDPGWEGLHCERCVRMPGCQHGTC--------HQP 74
CD L G C D + C C PG+ G CE V + GCQ C
Sbjct: 1181 CDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCE--VDISGCQSNPCGLGSYISGFHS 1238
Query: 75 WQCIC------HSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
+ C C + + +F + + + G + H G C
Sbjct: 1239 YSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTIC 1298
Query: 129 ERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGAT 188
+ PC +C A N C+C G++G+ C+ + D C N
Sbjct: 1299 KY----------PCGKSREC-----VAPNI-CKCKPGYIGSNCQTALCD---PDCKNHGK 1339
Query: 189 CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
C I C C G G C ++ + PCQ G C + C CP G+ G CE
Sbjct: 1340 C---IKPNICQCLPGHGGATCD---EEHCNPPCQHGGTC---LAGNLCTCPYGFVGPRCE 1390
Query: 249 LVL 251
++
Sbjct: 1391 TMV 1393
Score = 47.4 bits (111), Expect = 2e-05
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 2/89 (2%)
Query: 3 SGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVR 62
+G +C+ C G G+ C C C AP C C WEG+ C+ +
Sbjct: 1496 NGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPS-ICHCPSSWEGVRCQIPIC 1554
Query: 63 MPGCQH-GTCHQPWQCICHSGWAGKFCDK 90
P C + G C P C C + ++G C+K
Sbjct: 1555 NPKCLYGGRCIFPNVCSCRTEYSGVKCEK 1583
Score = 47.0 bits (110), Expect = 3e-05
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 10/74 (13%)
Query: 172 EVNVDDCLMRPCANGATCLD------GINRFSCLCPEGFAGRFCTINLDDCASRPCQRGA 225
EV V C C NG +C+ G + C+C GF G C +++ C S PC G+
Sbjct: 1175 EVTVKSC---DCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGS 1231
Query: 226 RCRDRVHDFDCLCP 239
H + C CP
Sbjct: 1232 YI-SGFHSYSCDCP 1244
Score = 29.3 bits (64), Expect = 6.2
Identities = 12/28 (42%), Positives = 13/28 (46%), Gaps = 5/28 (17%)
Query: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDC 128
C GQCM E+ C C P F DC
Sbjct: 894 CSGNGQCM-----EWGCACSPSFSSYDC 916
>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
Length = 4242
Score = 107 bits (268), Expect = 1e-23
Identities = 84/259 (32%), Positives = 109/259 (42%), Gaps = 60/259 (23%)
Query: 2 PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
P GC RC C+ C G G C C C +G C C+PG+ G C
Sbjct: 250 PRGCSQRGRCEGGRCV-CDPGYTGDDCGMRSCPRGCSQRGRC--ENGRCVCNPGYTGEDC 306
Query: 58 --ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSP--CQNGGQCMYDGG 112
C R GC Q G C + +C+C G+ G+ C T P C GG+C+ DG
Sbjct: 307 GVRSCPR--GCSQRGRC-KDGRCVCDPGYTGEDCG------TRSCPWDCGEGGRCV-DG- 355
Query: 113 GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
CVC PG+ G DC + P + CR G+C+D + C C G+ G
Sbjct: 356 ---RCVCWPGYTGEDCSTRTCPRD-----CRGRGRCEDGE-------CICDTGYSG---- 396
Query: 173 VNVDDCLMRPCANGAT----CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
DDC +R C C DG C+C G+ G DC SR C R R R
Sbjct: 397 ---DDCGVRSCPGDCNQRGRCEDG----RCVCWPGYTGT-------DCGSRACPRDCRGR 442
Query: 229 DRVHDFDCLCPSGYGGKTC 247
R + C+C +GY G+ C
Sbjct: 443 GRCENGVCVCNAGYSGEDC 461
Score = 105 bits (262), Expect = 7e-23
Identities = 74/247 (29%), Positives = 106/247 (42%), Gaps = 48/247 (19%)
Query: 6 RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
RC C+ C G G C C+ C DG C C PG+ G C
Sbjct: 382 RCEDGECI-CDTGYSGDDCGVRSCPGDCNQRGRC--EDGRCVCWPGYTGTDCGSRACPRD 438
Query: 66 CQ-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
C+ G C C+C++G++G+ C + + C+ G+C + G C+C PG+
Sbjct: 439 CRGRGRCENG-VCVCNAGYSGEDCG----VRSCPGDCRGRGRC--ESG---RCMCWPGYT 488
Query: 125 GRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCA 184
GRDC +A P + CR G+C D + C C GF G +DC R C
Sbjct: 489 GRDCGTRACPGD-----CRGRGRCVDGR-------CVCNPGFTG-------EDCGSRRCP 529
Query: 185 NGAT----CLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240
C DG+ C+C G++G +DC++R C G R R + D C+C
Sbjct: 530 GDCRGHGLCEDGV----CVCDAGYSG-------EDCSTRSCPGGCRGRGQCLDGRCVCED 578
Query: 241 GYGGKTC 247
GY G+ C
Sbjct: 579 GYSGEDC 585
Score = 103 bits (256), Expect = 3e-22
Identities = 73/245 (29%), Positives = 100/245 (40%), Gaps = 44/245 (17%)
Query: 6 RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
RC+ C+ C G G C C G C G C C G+ G C + G
Sbjct: 196 RCVRGRCV-CFPGYTGPSCGWPSCPGDCQ-GRGRCV-QGVCVCRAGFSGPDCSQRSCPRG 252
Query: 66 C-QHGTCHQPWQCICHSGWAGKFCDKDE--HICTTQSPCQNGGQCMYDGGGEYHCVCLPG 122
C Q G C + +C+C G+ G C C+ + C+NG CVC PG
Sbjct: 253 CSQRGRC-EGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENG-----------RCVCNPG 300
Query: 123 FHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRP 182
+ G DC ++ P C G+C+D + C C G+ G C C
Sbjct: 301 YTGEDCGVRSCP-----RGCSQRGRCKDGR-------CVCDPGYTGEDCGTR--SCPW-D 345
Query: 183 CANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGY 242
C G C+DG C+C G+ G +DC++R C R R R R D +C+C +GY
Sbjct: 346 CGEGGRCVDG----RCVCWPGYTG-------EDCSTRTCPRDCRGRGRCEDGECICDTGY 394
Query: 243 GGKTC 247
G C
Sbjct: 395 SGDDC 399
Score = 101 bits (251), Expect = 1e-21
Identities = 80/256 (31%), Positives = 101/256 (39%), Gaps = 39/256 (15%)
Query: 2 PSGCR----CLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
P CR C VC+ C G G+ C C G C DG C C+ G+ G C
Sbjct: 529 PGDCRGHGLCEDGVCV-CDAGYSGEDCSTRSCPGGCR-GRGQCL-DGRCVCEDGYSGEDC 585
Query: 58 ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C QHG C Q CIC G+ + C I T S C G+C E
Sbjct: 586 GVRQCPNDCSQHGVC-QDGVCICWEGYVSEDCS----IRTCPSNCHGRGRCE-----EGR 635
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
C+C PG+ G C + P + CR G+C QG C C VG+ G C +
Sbjct: 636 CLCDPGYTGPTCATRMCPAD-----CRGRGRCV--QG-----VCLCHVGYGGEDC--GQE 681
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
+ C G + C+C EGF G DCA + C R R HD C
Sbjct: 682 EPPASACPGGCGPRELCRAGQCVCVEGFRG-------PDCAIQTCPGDCRGRGECHDGSC 734
Query: 237 LCPSGYGGKTCELVLP 252
+C GY G+ C +P
Sbjct: 735 VCKDGYAGEDCGEEVP 750
Score = 91.3 bits (225), Expect = 1e-18
Identities = 62/218 (28%), Positives = 85/218 (38%), Gaps = 50/218 (22%)
Query: 45 SCRCDPGWEGLHC------ERCVRMPGCQHGTCHQP---------WQCICHSGWAGKFCD 89
+C C+PGW G C E P G+C +C+C G+ G C
Sbjct: 155 TCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCG 214
Query: 90 KDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQ 149
+ CQ G+C+ + CVC GF G DC +++ P C G+C+
Sbjct: 215 WP----SCPGDCQGRGRCV-----QGVCVCRAGFSGPDCSQRSCP-----RGCSQRGRCE 260
Query: 150 DDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFC 209
+ C C G+ G DDC MR C G + C+C G+ G
Sbjct: 261 GGR-------CVCDPGYTG-------DDCGMRSCPRGCSQRGRCENGRCVCNPGYTG--- 303
Query: 210 TINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
+DC R C RG R R D C+C GY G+ C
Sbjct: 304 ----EDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDC 337
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 103 bits (257), Expect = 3e-22
Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 43/251 (17%)
Query: 2 PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
PS C +C++ VC+ C G G + C C HG C DG C C G+ G C
Sbjct: 222 PSDCNDQGKCVNGVCI-CFEGYAGADCSREICPVPCSEEHGTCV-DGLCVCHDGFAGDDC 279
Query: 58 ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
+ + + C G C + +C+C G+ G+ C E IC + C + G+C+
Sbjct: 280 NKPLCLNNCYNRGRCVEN-ECVCDEGFTGEDC--SELIC--PNDCFDRGRCI-----NGT 329
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
C C GF G DC + P C G+C++ Q C C GF G C +
Sbjct: 330 CYCEEGFTGEDCGKPTCP-----HACHTQGRCEEGQ-------CVCDEGFAGVDCS---E 374
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
C N C+DG C C +GF G DC C G R + C
Sbjct: 375 KRCPADCHNRGRCVDG----RCECDDGFTGA-------DCGELKCPNGCSGHGRCVNGQC 423
Query: 237 LCPSGYGGKTC 247
+C GY G+ C
Sbjct: 424 VCDEGYTGEDC 434
Score = 103 bits (256), Expect = 3e-22
Identities = 73/244 (29%), Positives = 98/244 (40%), Gaps = 40/244 (16%)
Query: 6 RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
RC C+ C G G C + C C DG C CD G+ G C G
Sbjct: 355 RCEEGQCV-CDEGFAGVDCSEKRCPADCHNRGRCV--DGRCECDDGFTGADCGELKCPNG 411
Query: 66 CQ-HGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFH 124
C HG C QC+C G+ G+ C + + C + G+C+ E CVC GF
Sbjct: 412 CSGHGRCVNG-QCVCDEGYTGEDCSQ----LRCPNDCHSRGRCV-----EGKCVCEQGFK 461
Query: 125 GRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCA 184
G DC + P + C G+C +N C C G+ G C D R C+
Sbjct: 462 GYDCSDMSCP-----NDCHQHGRC-------VNGMCVCDDGYTGEDCR---DRQCPRDCS 506
Query: 185 NGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGG 244
N C+DG C+C +GF G DCA C + R + C+C G+ G
Sbjct: 507 NRGLCVDG----QCVCEDGFTG-------PDCAELSCPNDCHGQGRCVNGQCVCHEGFMG 555
Query: 245 KTCE 248
K C+
Sbjct: 556 KDCK 559
Score = 99.0 bits (245), Expect = 6e-21
Identities = 76/259 (29%), Positives = 104/259 (40%), Gaps = 44/259 (16%)
Query: 2 PSGC----RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC 57
P+GC RC++ C+ C G G+ C + C + G C +G C C+ G++G C
Sbjct: 409 PNGCSGHGRCVNGQCV-CDEGYTGEDCSQLRCPNDCH-SRGRCV-EGKCVCEQGFKGYDC 465
Query: 58 ERCVRMPGC-QHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYH 116
C QHG C C+C G+ G+ C + C N G C+ DG
Sbjct: 466 SDMSCPNDCHQHGRCVNG-MCVCDDGYTGEDCRDRQ----CPRDCSNRGLCV-DG----Q 515
Query: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
CVC GF G DC + P + C G+C + Q C C GF+G C+ +
Sbjct: 516 CVCEDGFTGPDCAELSCP-----NDCHGQGRCVNGQ-------CVCHEGFMGKDCK---E 560
Query: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
C C+DG C+C EGF G DC C + C
Sbjct: 561 QRCPSDCHGQGRCVDG----QCICHEGFTGL-------DCGQHSCPSDCNNLGQCVSGRC 609
Query: 237 LCPSGYGGKTCELVLPVPD 255
+C GY G+ C V P D
Sbjct: 610 ICNEGYSGEDCSEVSPPKD 628
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/238 (28%), Positives = 95/238 (39%), Gaps = 48/238 (20%)
Query: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ- 73
C+ A G+ CS + + C C C+PGW+G +C P C G CH
Sbjct: 147 CLQPATGRLDTRPFCSGRGNFSTEGCG----CVCEPGWKGPNCSE----PECP-GNCHLR 197
Query: 74 ----PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
QCIC G+ G+ C + S C + G+C+ C+C G+ G DC
Sbjct: 198 GRCIDGQCICDDGFTGEDCSQ----LACPSDCNDQGKCV-----NGVCICFEGYAGADCS 248
Query: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
R+ P C ++ G ++ C C GF G C N CL C N C
Sbjct: 249 REICPV-----------PCSEEHGTCVDGLCVCHDGFAGDDC--NKPLCL-NNCYNRGRC 294
Query: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC 247
++ C+C EGF G +DC+ C R R + C C G+ G+ C
Sbjct: 295 VEN----ECVCDEGFTG-------EDCSELICPNDCFDRGRCINGTCYCEEGFTGEDC 341
Score = 91.7 bits (226), Expect = 1e-18
Identities = 77/272 (28%), Positives = 106/272 (38%), Gaps = 56/272 (20%)
Query: 6 RCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPG 65
RC+ C+ C G G+ C + C G C +G+C C+ G+ G C + P
Sbjct: 293 RCVENECV-CDEGFTGEDCSELICPNDC-FDRGRCI-NGTCYCEEGFTGEDCGK----PT 345
Query: 66 CQHGTCH-----QPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 120
C H CH + QC+C G+AG C + + C N G+C+ DG C C
Sbjct: 346 CPHA-CHTQGRCEEGQCVCDEGFAGVDCSEKR----CPADCHNRGRCV-DG----RCECD 395
Query: 121 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGF-------------------ALNFTCR 161
GF G DC P +G GQC D+G+ + C
Sbjct: 396 DGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCV 455
Query: 162 CLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPC 221
C GF G C D C C++G+ C+C +G+ G +DC R C
Sbjct: 456 CEQGFKGYDCS---DMSCPNDCHQHGRCVNGM----CVCDDGYTG-------EDCRDRQC 501
Query: 222 QRGARCRDRVHDFDCLCPSGYGGKTC-ELVLP 252
R R D C+C G+ G C EL P
Sbjct: 502 PRDCSNRGLCVDGQCVCEDGFTGPDCAELSCP 533
Score = 89.0 bits (219), Expect = 7e-18
Identities = 57/177 (32%), Positives = 79/177 (44%), Gaps = 35/177 (19%)
Query: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
C+C GW G C + E C G+C+ DG C+C GF G DC + A P
Sbjct: 174 CVCEPGWKGPNCSEPE----CPGNCHLRGRCI-DG----QCICDDGFTGEDCSQLACP-- 222
Query: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
S C + G+C +N C C G+ GA C + C + TC+DG+
Sbjct: 223 ---SDCNDQGKC-------VNGVCICFEGYAGADCSREI--CPVPCSEEHGTCVDGL--- 267
Query: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTC-ELVLP 252
C+C +GFAG DDC C R R + +C+C G+ G+ C EL+ P
Sbjct: 268 -CVCHDGFAG-------DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICP 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.143 0.517
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,973,929
Number of Sequences: 37866
Number of extensions: 1314710
Number of successful extensions: 11556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 5229
Number of HSP's gapped (non-prelim): 2402
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.