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Search of human proteins with 4506341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform
a [Homo sapiens]
(659 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform ... 1319 0.0
gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo sa... 458 e-129
gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [H... 457 e-128
gi|169881286 ATP-binding cassette, sub-family D, member 3 isofor... 452 e-127
gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo sa... 253 5e-67
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 77 7e-14
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 77 7e-14
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 76 1e-13
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 74 4e-13
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 70 5e-12
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 69 1e-11
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 69 1e-11
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 69 1e-11
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 69 1e-11
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 69 2e-11
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 68 2e-11
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 68 3e-11
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 68 3e-11
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 68 3e-11
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 67 4e-11
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 67 5e-11
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 66 9e-11
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 66 1e-10
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 66 1e-10
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 66 1e-10
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 65 3e-10
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 63 8e-10
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 62 2e-09
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 60 8e-09
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 59 1e-08
>gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform a
[Homo sapiens]
Length = 659
Score = 1319 bits (3414), Expect = 0.0
Identities = 659/659 (100%), Positives = 659/659 (100%)
Query: 1 MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD 60
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD
Sbjct: 1 MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD 60
Query: 61 KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK 120
KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK
Sbjct: 61 KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK 120
Query: 121 DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN 180
DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
Sbjct: 121 DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN 180
Query: 181 RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS 240
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS
Sbjct: 181 RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS 240
Query: 241 GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV 300
GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV
Sbjct: 241 GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV 300
Query: 301 EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS 360
EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
Sbjct: 301 EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS 360
Query: 361 GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG 420
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG
Sbjct: 361 GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG 420
Query: 421 VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS 480
VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS
Sbjct: 421 VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS 480
Query: 481 SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL 540
SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
Sbjct: 481 SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL 540
Query: 541 VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA 600
VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA
Sbjct: 541 VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA 600
Query: 601 VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS 659
VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
Sbjct: 601 VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS 659
>gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo
sapiens]
Length = 740
Score = 458 bits (1179), Expect = e-129
Identities = 265/668 (39%), Positives = 396/668 (59%), Gaps = 29/668 (4%)
Query: 11 RNSSLAGAAFLLLCL---LHKRRRALGLHGKKSGK--PPLQNNE------KEGKKERAVV 59
R + L AA+ L L + KR + G HGKK P +N E +K V
Sbjct: 22 RAACLVAAAYALKTLYPIIGKRLKQSG-HGKKKAAAYPAAENTEILHCTETICEKPSPGV 80
Query: 60 DKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSR 119
+ FF +L+++ KI+ P+ ETG+L L +V L+SRT+ +++ I I+ +
Sbjct: 81 NADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKP 140
Query: 120 KDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLD 179
+ F L+ ++ + VN+ ++Y +L L FR RL + YE Y TYYK+ N+D
Sbjct: 141 RTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMD 200
Query: 180 NRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPA----SMMA 235
R+ANPDQ LT+D+ F SV LYSNL+KP LD++L + L ++G + +++A
Sbjct: 201 GRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLA 260
Query: 236 YLVV--SGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVH 293
LVV + L GK+ E +G RYV+SR+I N EEIAFY G+K E + +
Sbjct: 261 GLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQ 320
Query: 294 SVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLS-----HPRHLKS 348
++ L + ++ + R I+ + KY+ + G ++V+ P + + +
Sbjct: 321 KSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQV 380
Query: 349 THSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYER 408
SE E + + +L + A+ RI+ + +E+T LAG+TAR+ + V ++ G Y+R
Sbjct: 381 MVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKR 440
Query: 409 TMVSQQEKGIE--GVQV-IPL---IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFE 462
T V Q+ + G +V +PL + G++I D+ I ++VP+ TP G+V+ LNF+
Sbjct: 441 TAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFK 500
Query: 463 VRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQ 522
V G ++LI GPNGCGKSSLFR+L LWP++ G L KP +FY+PQRPYM+LG+LRDQ
Sbjct: 501 VEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQ 560
Query: 523 VIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMA 582
VIYPD +D KG +D L+ L NV L HI++REGGWD+V DW DVLSGGEKQRM MA
Sbjct: 561 VIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMA 620
Query: 583 RLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGR 642
R+FYHKP++A+LDECTSAVS+DVEG I+ + GI+L +++HR SLWK+H + L DG
Sbjct: 621 RMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGE 680
Query: 643 GNYEFKQI 650
G + F+Q+
Sbjct: 681 GGWRFEQL 688
>gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [Homo
sapiens]
Length = 745
Score = 457 bits (1176), Expect = e-128
Identities = 245/621 (39%), Positives = 377/621 (60%), Gaps = 26/621 (4%)
Query: 56 RAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGII 115
+A +++VF RL+ +L+++ PR C+ETG L L + LVSRT+ V++ + + I+
Sbjct: 64 KAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIV 123
Query: 116 GRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKM 175
+ + F LL ++ + VN+ ++Y +L L FR RL + Y Y TYY++
Sbjct: 124 RKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRV 183
Query: 176 GNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPA---- 231
N+D R+ NPDQ LT+DV F SV LYSNL+KP LD+ + + L A ++G
Sbjct: 184 SNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWP 243
Query: 232 SMMAYLVV--SGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREK 289
S +A LVV + L G++ E + +GE RY++SR++ NSEEIAFY G++ E
Sbjct: 244 SAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVEL 303
Query: 290 QTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDL-----SHPR 344
+ ++ L ++ +L R ++ + KY+ + G L+V+ P + S
Sbjct: 304 ALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAE 363
Query: 345 HLKSTHSELLEDYYQSGR---------MLLRMSQALGRIVLAGREMTRLAGFTARITELM 395
+K E E+ S R +L + A+ RI+ + +E+T LAG+TAR+ E+
Sbjct: 364 AVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMF 423
Query: 396 QVLKDLNHGKYERTMVSQQEK------GIEGVQVIPLIPGAGEIIIADNIIKFDHVPLAT 449
QV +D+ ++R + + G GV+V + G+++ + I +++P+ T
Sbjct: 424 QVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIPIVT 483
Query: 450 PNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVP 509
P+G+V++ LN V G ++LI GPNGCGKSSLFR+LG LWP +GG L KP ++FY+P
Sbjct: 484 PSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIP 543
Query: 510 QRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMD 569
QRPYM++G+LRDQVIYPD ED +RKG S+ L+ LD V L HIL+REGGW+++ DW D
Sbjct: 544 QRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKD 603
Query: 570 VLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSL 629
VLSGGEKQR+ MAR+FYH+P++A+LDECTSAVS+DVEG I+ + GI L +++HR SL
Sbjct: 604 VLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSL 663
Query: 630 WKHHEYYLHMDGRGNYEFKQI 650
WK+H + L DG G ++F+++
Sbjct: 664 WKYHTHLLQFDGEGGWKFEKL 684
>gi|169881286 ATP-binding cassette, sub-family D, member 3 isoform b
[Homo sapiens]
Length = 236
Score = 452 bits (1163), Expect = e-127
Identities = 228/228 (100%), Positives = 228/228 (100%)
Query: 1 MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD 60
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD
Sbjct: 1 MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD 60
Query: 61 KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK 120
KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK
Sbjct: 61 KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK 120
Query: 121 DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN 180
DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
Sbjct: 121 DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN 180
Query: 181 RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQ 228
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQ
Sbjct: 181 RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQ 228
>gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo
sapiens]
Length = 606
Score = 253 bits (645), Expect = 5e-67
Identities = 181/616 (29%), Positives = 312/616 (50%), Gaps = 38/616 (6%)
Query: 52 GKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIE 111
G R +D F R +QILK++ P + L+ + L+ T + ++I LI
Sbjct: 9 GAGARPRLDLQFLQRFLQILKVLFPSWSSQNA----LMFLTLLCLTLLEQFVIYQVGLIP 64
Query: 112 S---GIIGRSRKDFKRY-LLNFIAAMPLI--SLVNNFLKYGLNELKLCFRVRLTKYLYEE 165
S G++G KD + + L F+A M ++ S + +F ++ N L + +R LT++L+
Sbjct: 65 SQYYGVLGN--KDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRL 122
Query: 166 YLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAI 225
Y + YY + L + I NPDQ ++QDVE+FC + + S L +V Y ++ +
Sbjct: 123 YFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQST 182
Query: 226 GAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGN 285
G GP S+ Y ++ + L PI + ++K EG++R+ + ++ N+E AFY
Sbjct: 183 GWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAG 242
Query: 286 KREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFL-----DL 340
E ++L++ + + +I YL +++ Y+V++ P DL
Sbjct: 243 HVEHMRTDRRLQRLLQTQRELMSKELWL-YIGINTFDYLGSILSYVVIAIPIFSGVYGDL 301
Query: 341 SHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKD 400
S P L + S ++ + + + +++ ++ +AG+T RI +L + L D
Sbjct: 302 S-PAELSTLVS-------KNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLD 353
Query: 401 LNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGD-VLIRDL 459
++ + ++ + E G++ PG AD + V ++ P+ D LI+DL
Sbjct: 354 MSLKSQDCEILGESEWGLD------TPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDL 407
Query: 460 NFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGG---RLTKPERGKLFYVPQRPYMTL 516
+ ++ G ++LI G G GK+SL RVLG LW G LT + ++PQ+P+ T
Sbjct: 408 SLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTD 467
Query: 517 GTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQD--WMDVLSGG 574
GTLR+QVIYP D + +L+ L +++ R G D D W DVLS G
Sbjct: 468 GTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPG 527
Query: 575 EKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHE 634
E QR++ ARLFY +P++A+LDE TSA++ +VE +Y +++G+T +V HR+SL K H
Sbjct: 528 EMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHS 587
Query: 635 YYLHMDGRGNYEFKQI 650
L + G G +E +I
Sbjct: 588 LVLKLCGGGRWELMRI 603
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 76.6 bits (187), Expect = 7e-14
Identities = 54/160 (33%), Positives = 81/160 (50%), Gaps = 12/160 (7%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFR-VLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++ L+F VR G + + GP G GKSSL VLGEL P G G++ YV Q+P++
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHG---LVSVHGRIAYVSQQPWV 484
Query: 515 TLGTLRDQVIYPDGREDQK-RKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSG 573
GTLR +++ E ++ K I LK+ L L +G + D LSG
Sbjct: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ-------LLEDGDLTVIGDRGTTLSG 537
Query: 574 GEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHC 613
G+K R+ +AR Y +LD+ SAV +V +++ C
Sbjct: 538 GQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 76.6 bits (187), Expect = 7e-14
Identities = 54/160 (33%), Positives = 81/160 (50%), Gaps = 12/160 (7%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFR-VLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++ L+F VR G + + GP G GKSSL VLGEL P G G++ YV Q+P++
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHG---LVSVHGRIAYVSQQPWV 484
Query: 515 TLGTLRDQVIYPDGREDQK-RKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSG 573
GTLR +++ E ++ K I LK+ L L +G + D LSG
Sbjct: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ-------LLEDGDLTVIGDRGTTLSG 537
Query: 574 GEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHC 613
G+K R+ +AR Y +LD+ SAV +V +++ C
Sbjct: 538 GQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/209 (25%), Positives = 98/209 (46%), Gaps = 31/209 (14%)
Query: 437 DNIIKFDHVP-LATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVL-------GE 488
+ +I FD+V + +P G ++++ L ++S V I G G GKSSL L G+
Sbjct: 1038 EGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGK 1097
Query: 489 LWPLFGGRLTKPE------RGKLFYVPQRPYMTLGTLRDQV-IYPDGREDQKRKGISDLV 541
+W ++ E R K+ +PQ P + GT+R + + + +++ + ++
Sbjct: 1098 IWI---DKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQ 1154
Query: 542 LKEYLDNV--QLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTS 599
LKE ++++ ++ L G SV G++Q + +AR K Q I+DE T+
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSV---------GQRQLVCLARAILRKNQILIIDEATA 1205
Query: 600 AVSVDVEGYIYSHCRK--VGITLFTVSHR 626
V + I R+ T+ T++HR
Sbjct: 1206 NVDPRTDELIQKKIREKFAHCTVLTIAHR 1234
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/253 (25%), Positives = 113/253 (44%), Gaps = 31/253 (12%)
Query: 411 VSQQEKGIEGVQVIPLIPGAGEII--IADNIIKFDHVPLATPNGD--VLIRDLNFEVRSG 466
V EK + P +P G + ++KF V A PN +++ L F +R G
Sbjct: 437 VGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPG 496
Query: 467 ANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPER-----------GKLFYVPQRPYMT 515
+ GPNG GKS++ +L L+ GG++ E+ ++ V Q P +
Sbjct: 497 EVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLF 556
Query: 516 LGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGH----ILEREGG-WDSVQDWMDV 570
G++R+ + Y G+ + + Q H I E E G + V +
Sbjct: 557 SGSVRNNIAY----------GLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 606
Query: 571 LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHR-KSL 629
L+ G+KQR+A+AR P+ ILDE TSA+ V E + + T+ ++HR +++
Sbjct: 607 LAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQAV 666
Query: 630 WKHHEYYLHMDGR 642
+ H+ + +G+
Sbjct: 667 QRAHQILVLQEGK 679
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 73.9 bits (180), Expect = 4e-13
Identities = 62/211 (29%), Positives = 99/211 (46%), Gaps = 10/211 (4%)
Query: 427 IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVL 486
+PGAG + I+F++V + +G ++D++F V G + + GP+G GKS++ R+L
Sbjct: 577 LPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLL 636
Query: 487 GELWPLFGG--RLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKE 544
+ + G R+ + ++ R ++ + +D V++ D D R G E
Sbjct: 637 FRFYDISSGCIRIDGQDISQVTQASLRSHIGV-VPQDTVLFNDTIADNIRYGRVTAGNDE 695
Query: 545 YLDNVQLGHILER-----EGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTS 599
Q I + EG V + LSGGEKQR+A+AR P +LDE TS
Sbjct: 696 VEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATS 755
Query: 600 AVSVDVEGYIYSHCRKV--GITLFTVSHRKS 628
A+ E I + KV T V+HR S
Sbjct: 756 ALDTSNERAIQASLAKVCANRTTIVVAHRLS 786
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 70.5 bits (171), Expect = 5e-12
Identities = 60/216 (27%), Positives = 95/216 (43%), Gaps = 30/216 (13%)
Query: 411 VSQQEKGIEGVQVIPLIPGAGEII--IADNIIKFDHVPLATPNGD--VLIRDLNFEVRSG 466
V EK + P +P G + ++KF V A PN +++ L F +R G
Sbjct: 437 VGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPG 496
Query: 467 ANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPER-----------GKLFYVPQRPYMT 515
+ GPNG GKS++ +L L+ GG++ E+ ++ V Q P +
Sbjct: 497 EVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLF 556
Query: 516 LGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGH----ILEREGG-WDSVQDWMDV 570
G++R+ + Y G+ + + Q H I E E G + V +
Sbjct: 557 SGSVRNNIAY----------GLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 606
Query: 571 LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVE 606
L+ G+KQR+A+AR P+ ILDE TSA+ V E
Sbjct: 607 LAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/164 (31%), Positives = 87/164 (53%), Gaps = 14/164 (8%)
Query: 451 NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFR-VLGELWPLFGGRLTKPERGKLFYVP 509
+ + +RD+N ++ +G V + GP G GKSSL +LGE+ + G K G YVP
Sbjct: 649 DSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIK---GTTAYVP 705
Query: 510 QRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWD--SVQDW 567
Q+ ++ GT++D +++ G E +++ ++ L+ L LE G D + +
Sbjct: 706 QQSWIQNGTIKDNILF--GTEFNEKR------YQQVLEACALLPDLEMLPGGDLAEIGEK 757
Query: 568 MDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYS 611
LSGG+KQR+++AR Y +LD+ SAV V +I++
Sbjct: 758 GINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Score = 62.4 bits (150), Expect = 1e-09
Identities = 58/241 (24%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 407 ERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSG 466
E T V + + + P P G+I + +++ P D+++R + ++ S
Sbjct: 1274 EYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRY------RPELDLVLRGITCDIGSM 1327
Query: 467 ANVLICGPNGCGKSSLFRVLGELWPLFGGRL-----------TKPERGKLFYVPQRPYMT 515
+ + G G GKSSL L + GG++ R KL +PQ P +
Sbjct: 1328 EKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILF 1387
Query: 516 LGTLRDQV-IYPDGREDQKRKGISDLVLKEYLDNVQLG--HILEREGGWDSVQDWMDVLS 572
G+LR + + + +++ K + LK ++ ++QLG H + GG LS
Sbjct: 1388 SGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG---------NLS 1438
Query: 573 GGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYI-------YSHCRKVGITLFTVSH 625
G++Q + + R K + +LDE T+AV ++ + I ++HC T+ T++H
Sbjct: 1439 IGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHC-----TVITIAH 1493
Query: 626 R 626
R
Sbjct: 1494 R 1494
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 68.9 bits (167), Expect = 1e-11
Identities = 52/194 (26%), Positives = 92/194 (47%), Gaps = 8/194 (4%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++++++F + G + GP+G GKSS +L +PL GGR+ + Y + +
Sbjct: 478 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 537
Query: 515 TLGTL-RDQVIYPDGREDQKRKGISDLVLKEYLDNVQL----GHILEREGGWDSVQDWMD 569
+ + ++ V++ D G+ + + ++ Q G I+E + G+ +
Sbjct: 538 VISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKG 597
Query: 570 V-LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYS--HCRKVGITLFTVSHR 626
LSGG+KQR+AMAR P ILDE TSA+ + E I H T+ ++HR
Sbjct: 598 AQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHR 657
Query: 627 KSLWKHHEYYLHMD 640
S +H + +D
Sbjct: 658 LSTVEHAHLIVVLD 671
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 68.9 bits (167), Expect = 1e-11
Identities = 52/194 (26%), Positives = 92/194 (47%), Gaps = 8/194 (4%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++++++F + G + GP+G GKSS +L +PL GGR+ + Y + +
Sbjct: 521 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 580
Query: 515 TLGTL-RDQVIYPDGREDQKRKGISDLVLKEYLDNVQL----GHILEREGGWDSVQDWMD 569
+ + ++ V++ D G+ + + ++ Q G I+E + G+ +
Sbjct: 581 VISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKG 640
Query: 570 V-LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYS--HCRKVGITLFTVSHR 626
LSGG+KQR+AMAR P ILDE TSA+ + E I H T+ ++HR
Sbjct: 641 AQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHR 700
Query: 627 KSLWKHHEYYLHMD 640
S +H + +D
Sbjct: 701 LSTVEHAHLIVVLD 714
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 68.9 bits (167), Expect = 1e-11
Identities = 52/194 (26%), Positives = 92/194 (47%), Gaps = 8/194 (4%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++++++F + G + GP+G GKSS +L +PL GGR+ + Y + +
Sbjct: 521 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 580
Query: 515 TLGTL-RDQVIYPDGREDQKRKGISDLVLKEYLDNVQL----GHILEREGGWDSVQDWMD 569
+ + ++ V++ D G+ + + ++ Q G I+E + G+ +
Sbjct: 581 VISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKG 640
Query: 570 V-LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYS--HCRKVGITLFTVSHR 626
LSGG+KQR+AMAR P ILDE TSA+ + E I H T+ ++HR
Sbjct: 641 AQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHR 700
Query: 627 KSLWKHHEYYLHMD 640
S +H + +D
Sbjct: 701 LSTVEHAHLIVVLD 714
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/277 (25%), Positives = 125/277 (45%), Gaps = 31/277 (11%)
Query: 387 FTARITELMQVLKDLNHGKYERTM--VSQQEKGIEGVQVIPLIPGAGEI--IIADNIIKF 442
+ + T+ ++VL + Y R V EK E + P P +G + + + +++F
Sbjct: 510 YQMQFTQAVEVLLSI----YPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQF 565
Query: 443 DHVPLATPNG-DVLI-RDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKP 500
V A PN DVL+ + L F +R G + GPNG GKS++ +L L+ GG+L
Sbjct: 566 QDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLD 625
Query: 501 ERGKLFY-----------VPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNV 549
+ Y V Q P + +L++ + Y +K + + + +
Sbjct: 626 GKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAY-----GLTQKPTMEEITAAAVKSG 680
Query: 550 QLGHILEREGGWDS-VQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAV----SVD 604
I G+D+ V + LSGG++Q +A+AR KP ILD+ TSA+ +
Sbjct: 681 AHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQ 740
Query: 605 VEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDG 641
VE +Y + ++ ++ SL + ++ L ++G
Sbjct: 741 VEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEG 777
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 68.2 bits (165), Expect = 2e-11
Identities = 108/465 (23%), Positives = 183/465 (39%), Gaps = 59/465 (12%)
Query: 154 FRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLD 213
FR + +Y + L K + I N L++ D ++F + L S P L
Sbjct: 381 FRTGIMGVIYRKALVITNSVKRASTVGEIVN---LMSVDAQRFMDLAPFLNLLWSAP-LQ 436
Query: 214 IVLYIFKLTSAIGAQ---GPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS 270
I+L I+ L +G G A M+ + ++G ++R + + K + + S
Sbjct: 437 IILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRA----FQVKQMKLKDSRIKLMS 492
Query: 271 RLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGY 330
++ + + Y + V + + ++ L A YL T +
Sbjct: 493 EILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRT---------------AAYLHTTTTF 537
Query: 331 LVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTAR 390
+ PFL T L Y +L +A + L L
Sbjct: 538 TWMCSPFL---------VTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQL 588
Query: 391 ITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATP 450
I+ L Q L K + +SQ+E + V+ + PG I + +P
Sbjct: 589 ISNLTQASVSL---KRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPT-- 643
Query: 451 NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFR-VLGELWPLFGGRLTKPERGKLFYVP 509
+ L+ +V GA V + GP GCGKSSL +LGE+ L G K G + YVP
Sbjct: 644 -----LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMK---GSVAYVP 695
Query: 510 QRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQ--DW 567
Q+ ++ TL++ V++ K ++ ++ L+ L LE G D + +
Sbjct: 696 QQAWIQNCTLQENVLFG--------KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK 747
Query: 568 MDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSH 612
LSGG++QR+++AR Y +LD+ SAV V +I+ H
Sbjct: 748 GINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDH 792
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/214 (27%), Positives = 99/214 (46%), Gaps = 29/214 (13%)
Query: 428 PGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSS----LF 483
P GE+ + +++ P D+++RDL+ V G V I G G GKSS LF
Sbjct: 1284 PPRGEVEFRNYSVRY------RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLF 1337
Query: 484 RVL----GELWPLFGGRLT----KPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRK 535
R+L GE+ + G + R +L +PQ P + GTLR + P G ++
Sbjct: 1338 RILEAAKGEI-RIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLR-MNLDPFGSYSEE-- 1393
Query: 536 GISDLVLKEYLDNVQLGHILEREGGWD-SVQDWMDVLSGGEKQRMAMARLFYHKPQFAIL 594
D+ L ++ + + G D + + LS G++Q + +AR K + +L
Sbjct: 1394 ---DIWWALELSHLHT-FVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVL 1449
Query: 595 DECTSAVSVDVEGYIYSHCRKV--GITLFTVSHR 626
DE T+A+ ++ + I + R T+ T++HR
Sbjct: 1450 DEATAAIDLETDNLIQATIRTQFDTCTVLTIAHR 1483
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 67.8 bits (164), Expect = 3e-11
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMT 515
+ +N V G + +CG G GKSSL + E L G + +G L YVPQ+ ++
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV--QGSLAYVPQQAWIV 584
Query: 516 LGTLRDQVI----YPDGREDQKRKGIS---DLVLKEYLDNVQLGHILEREGGWDSVQDWM 568
G +R+ ++ Y R Q S DL L + D ++G E G +
Sbjct: 585 SGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIG-----ERGLN------ 633
Query: 569 DVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV---GITLFTVSH 625
LSGG+KQR+++AR Y Q +LD+ SAV V +I+ C K G T+ V+H
Sbjct: 634 --LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTH 691
Query: 626 R 626
+
Sbjct: 692 Q 692
Score = 44.3 bits (103), Expect = 4e-04
Identities = 59/256 (23%), Positives = 93/256 (36%), Gaps = 63/256 (24%)
Query: 405 KYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVR 464
+Y + VS+ +EG P GEII D +K+ N ++ +N +R
Sbjct: 1113 QYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKY------RDNTPTVLHGINLTIR 1166
Query: 465 SGANVLICGPNGCGKSSLFRVLGELWPLFGGRL-----------TKPERGKLFYVPQRPY 513
V I G G GKSSL L L GR+ + R KL +PQ P
Sbjct: 1167 GHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPV 1226
Query: 514 MTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSG 573
+ GT+R + D DQ+ WD
Sbjct: 1227 LLSGTIRFNLDPFDRHTDQQI--------------------------WD----------- 1249
Query: 574 GEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GITLFTVSHRKSLWK 631
A+ R F K ++DE T+++ ++ + I R+ G T+ ++HR +
Sbjct: 1250 ------ALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVL 1302
Query: 632 HHEYYLHMDGRGNYEF 647
+ ++ L M EF
Sbjct: 1303 NCDHILVMGNGKVVEF 1318
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 67.8 bits (164), Expect = 3e-11
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMT 515
+ +N V G + +CG G GKSSL + E L G + +G L YVPQ+ ++
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV--QGSLAYVPQQAWIV 584
Query: 516 LGTLRDQVI----YPDGREDQKRKGIS---DLVLKEYLDNVQLGHILEREGGWDSVQDWM 568
G +R+ ++ Y R Q S DL L + D ++G E G +
Sbjct: 585 SGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIG-----ERGLN------ 633
Query: 569 DVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV---GITLFTVSH 625
LSGG+KQR+++AR Y Q +LD+ SAV V +I+ C K G T+ V+H
Sbjct: 634 --LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTH 691
Query: 626 R 626
+
Sbjct: 692 Q 692
Score = 61.6 bits (148), Expect = 2e-09
Identities = 68/266 (25%), Positives = 107/266 (40%), Gaps = 45/266 (16%)
Query: 405 KYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVR 464
+Y + VS+ +EG P GEII D +K+ N ++ +N +R
Sbjct: 1113 QYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKY------RDNTPTVLHGINLTIR 1166
Query: 465 SGANVLICGPNGCGKSSLFRVLGELWPLFGGRLT-----------KPERGKLFYVPQRPY 513
V I G G GKSSL L L GR+ + R KL +PQ P
Sbjct: 1167 GHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPV 1226
Query: 514 MTLGTLRDQVIYPDGREDQK----------RKGISDLVLKEYLDNVQLGHILEREGGWDS 563
+ GT+R + D DQ+ K IS K + D V+ GG S
Sbjct: 1227 LLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVE-------NGGNFS 1279
Query: 564 VQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GITLF 621
V GE+Q + +AR + ++DE T+++ ++ + I R+ G T+
Sbjct: 1280 V---------GERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVL 1330
Query: 622 TVSHRKSLWKHHEYYLHMDGRGNYEF 647
++HR + + ++ L M EF
Sbjct: 1331 VIAHRVTTVLNCDHILVMGNGKVVEF 1356
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 67.8 bits (164), Expect = 3e-11
Identities = 57/181 (31%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMT 515
+ +N V G + +CG G GKSSL + E L G + +G L YVPQ+ ++
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV--QGSLAYVPQQAWIV 584
Query: 516 LGTLRDQVI----YPDGREDQKRKGIS---DLVLKEYLDNVQLGHILEREGGWDSVQDWM 568
G +R+ ++ Y R Q S DL L + D ++G E G +
Sbjct: 585 SGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIG-----ERGLN------ 633
Query: 569 DVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV---GITLFTVSH 625
LSGG+KQR+++AR Y Q +LD+ SAV V +I+ C K G T+ V+H
Sbjct: 634 --LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTH 691
Query: 626 R 626
+
Sbjct: 692 Q 692
Score = 61.6 bits (148), Expect = 2e-09
Identities = 68/266 (25%), Positives = 107/266 (40%), Gaps = 45/266 (16%)
Query: 405 KYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVR 464
+Y + VS+ +EG P GEII D +K+ N ++ +N +R
Sbjct: 1113 QYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKY------RDNTPTVLHGINLTIR 1166
Query: 465 SGANVLICGPNGCGKSSLFRVLGELWPLFGGRLT-----------KPERGKLFYVPQRPY 513
V I G G GKSSL L L GR+ + R KL +PQ P
Sbjct: 1167 GHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPV 1226
Query: 514 MTLGTLRDQVIYPDGREDQK----------RKGISDLVLKEYLDNVQLGHILEREGGWDS 563
+ GT+R + D DQ+ K IS K + D V+ GG S
Sbjct: 1227 LLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVE-------NGGNFS 1279
Query: 564 VQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GITLF 621
V GE+Q + +AR + ++DE T+++ ++ + I R+ G T+
Sbjct: 1280 V---------GERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVL 1330
Query: 622 TVSHRKSLWKHHEYYLHMDGRGNYEF 647
++HR + + ++ L M EF
Sbjct: 1331 VIAHRVTTVLNCDHILVMGNGKVVEF 1356
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 67.4 bits (163), Expect = 4e-11
Identities = 62/237 (26%), Positives = 111/237 (46%), Gaps = 36/237 (15%)
Query: 437 DNI---IKFDHVPLATPNGDV--LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWP 491
DNI ++F +V + P+ +++ LN +V+SG V + G +GCGKS+ +++ L+
Sbjct: 386 DNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYD 445
Query: 492 LFGGRLTKPE-----------RGKLFYVPQRPYMTLGTLRDQVIYPDGRE----DQKRKG 536
G ++ R + V Q P + T+ + + Y GRE D+ K
Sbjct: 446 PTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRY--GRENVTMDEIEKA 503
Query: 537 ISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDE 596
+ + +++ ++L H + G Q LSGG+KQR+A+AR P+ +LDE
Sbjct: 504 VKEANAYDFI--MKLPHKFDTLVGERGAQ-----LSGGQKQRIAIARALVRNPKILLLDE 556
Query: 597 CTSAVSVDVEGYIYSHCRKV--GITLFTVSHRKSLWKHHEYYLHMDG-----RGNYE 646
TSA+ + E + K G T ++HR S ++ + D +GN++
Sbjct: 557 ATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHD 613
Score = 60.8 bits (146), Expect = 4e-09
Identities = 48/191 (25%), Positives = 90/191 (47%), Gaps = 24/191 (12%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELW-PLFGGRLTKPE----------RG 503
+++ L+ EV+ G + + G +GCGKS++ ++L + PL G L + R
Sbjct: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRA 1111
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGR----EDQKRKGISDLVLKEYLDNVQLGHILEREG 559
L V Q P + ++ + + Y D +++ + + + +++++ + +
Sbjct: 1112 HLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTK--- 1168
Query: 560 GWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--G 617
V D LSGG+KQR+A+AR +P +LDE TSA+ + E + K G
Sbjct: 1169 ----VGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG 1224
Query: 618 ITLFTVSHRKS 628
T ++HR S
Sbjct: 1225 RTCIVIAHRLS 1235
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/177 (29%), Positives = 90/177 (50%), Gaps = 15/177 (8%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
++ ++F VR G + ICG G GKSSL L L G + G L YV Q+ ++
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAV--NGTLAYVSQQAWI 552
Query: 515 TLGTLRDQVIYPDGREDQK-RKGISDLVLKEYLDNVQLGHILE-REGGWDSVQDWMDVLS 572
G +R+ +++ + + Q+ + + L++ L N+ G + E E G + LS
Sbjct: 553 FHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN--------LS 604
Query: 573 GGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV---GITLFTVSHR 626
GG++QR+++AR Y Q +LD+ SAV V +++ C K G T+ V+H+
Sbjct: 605 GGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQ 661
Score = 57.4 bits (137), Expect = 4e-08
Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 39/240 (16%)
Query: 428 PGAGEIIIADNIIKF-DHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVL 486
P GEI D +++ D+ PL ++ LN ++SG V I G G GKSSL L
Sbjct: 1115 PSRGEITFRDYQMRYRDNTPL-------VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMAL 1167
Query: 487 GELWPLFGGRLTKPE-----------RGKLFYVPQRPYMTLGTLRDQVIYPDGREDQ--- 532
L G + E R KL +PQ P + +GT+R + + D+
Sbjct: 1168 FRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLW 1227
Query: 533 ---KRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKP 589
+R + D ++K L L+ E V + + S GE+Q + +AR
Sbjct: 1228 QVLERTFMRDTIMK-------LPEKLQAE-----VTENGENFSVGERQLLCVARALLRNS 1275
Query: 590 QFAILDECTSAVSVDVEGYIYSHCRKV--GITLFTVSHRKSLWKHHEYYLHMDGRGNYEF 647
+ +LDE T+++ + + + + G T+ T++HR + + ++ L M+ EF
Sbjct: 1276 KIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEF 1335
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 66.2 bits (160), Expect = 9e-11
Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 24/191 (12%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWP------LFGGRLTKPE-----RG 503
++R L+ + G V G +GCGKS+ ++L L+ LF G K R
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGRE----DQKRKGISDLVLKEYLDNVQLGHILEREG 559
++ VPQ P + ++ + + Y D D+ ++ + + +++ L +
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEG--LPEKYNTQV 704
Query: 560 GWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRK--VG 617
G Q LSGG+KQR+A+AR KP+ +LDE TSA+ D E + K G
Sbjct: 705 GLKGAQ-----LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTG 759
Query: 618 ITLFTVSHRKS 628
T V+HR S
Sbjct: 760 RTCLVVTHRLS 770
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/60 (40%), Positives = 35/60 (58%), Gaps = 2/60 (3%)
Query: 571 LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GITLFTVSHRKS 628
+SGG+KQR+A+AR P+ ILDE TSA+ + + + + K G T V+HR S
Sbjct: 80 MSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLS 139
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 22/189 (11%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPE-----------RG 503
+++ LN +V+SG V + G +GCGKS+ +++ L+ G + R
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGRE--DQKRKGISDLVLKEYLDNVQLGHILEREGGW 561
+ V Q P + T+ + + Y G D+ +K + + E++ ++L + G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTLVGE 528
Query: 562 DSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GIT 619
Q LSGG+KQR+A+AR P+ +LDE TSA+ + E + + K G T
Sbjct: 529 RGAQ-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 583
Query: 620 LFTVSHRKS 628
++HR S
Sbjct: 584 TIVIAHRLS 592
Score = 63.5 bits (153), Expect = 6e-10
Identities = 53/198 (26%), Positives = 91/198 (45%), Gaps = 31/198 (15%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVL--------GELWPLFGGRLTKPE----- 501
+++ L+ EV+ G + + G +GCGKS++ ++L G ++ FG +L +
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKL 1110
Query: 502 -----RGKLFYVPQRPYMTLGTLRDQVIYPDGR----EDQKRKGISDLVLKEYLDNVQLG 552
R +L V Q P + ++ + + Y D +D+ + +++ L
Sbjct: 1111 NVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET--LP 1168
Query: 553 HILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSH 612
H E G Q LSGG+KQR+A+AR +PQ +LDE TSA+ + E +
Sbjct: 1169 HKYETRVGDKGTQ-----LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEA 1223
Query: 613 CRKV--GITLFTVSHRKS 628
K G T ++HR S
Sbjct: 1224 LDKAREGRTCIVIAHRLS 1241
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 22/189 (11%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPE-----------RG 503
+++ LN +V+SG V + G +GCGKS+ +++ L+ G + R
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGRE--DQKRKGISDLVLKEYLDNVQLGHILEREGGW 561
+ V Q P + T+ + + Y G D+ +K + + E++ ++L + G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTLVGE 528
Query: 562 DSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GIT 619
Q LSGG+KQR+A+AR P+ +LDE TSA+ + E + + K G T
Sbjct: 529 RGAQ-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 583
Query: 620 LFTVSHRKS 628
++HR S
Sbjct: 584 TIVIAHRLS 592
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 24/191 (12%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELW-PLFGGRLTKPE----------RG 503
+++ L+ EV+ G + + G +GCGKS++ ++L + PL G L + R
Sbjct: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1063
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGR----EDQKRKGISDLVLKEYLDNVQLGHILEREG 559
+L V Q P + ++ + + Y D +D+ + +++ L H E
Sbjct: 1064 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET--LPHKYETRV 1121
Query: 560 GWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--G 617
G Q LSGG+KQR+A+AR +PQ +LDE TSA+ + E + K G
Sbjct: 1122 GDKGTQ-----LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG 1176
Query: 618 ITLFTVSHRKS 628
T ++HR S
Sbjct: 1177 RTCIVIAHRLS 1187
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 22/189 (11%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPE-----------RG 503
+++ LN +V+SG V + G +GCGKS+ +++ L+ G + R
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGRE--DQKRKGISDLVLKEYLDNVQLGHILEREGGW 561
+ V Q P + T+ + + Y G D+ +K + + E++ ++L + G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTLVGE 528
Query: 562 DSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GIT 619
Q LSGG+KQR+A+AR P+ +LDE TSA+ + E + + K G T
Sbjct: 529 RGAQ-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 583
Query: 620 LFTVSHRKS 628
++HR S
Sbjct: 584 TIVIAHRLS 592
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 24/191 (12%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELW-PLFGGRLTKPE----------RG 503
+++ L+ EV+ G + + G +GCGKS++ ++L + PL G L + R
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1110
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGR----EDQKRKGISDLVLKEYLDNVQLGHILEREG 559
+L V Q P + ++ + + Y D +D+ + +++ L H E
Sbjct: 1111 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET--LPHKYETRV 1168
Query: 560 GWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--G 617
G Q LSGG+KQR+A+AR +PQ +LDE TSA+ + E + K G
Sbjct: 1169 GDKGTQ-----LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG 1223
Query: 618 ITLFTVSHRKS 628
T ++HR S
Sbjct: 1224 RTCIVIAHRLS 1234
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 64.7 bits (156), Expect = 3e-10
Identities = 52/192 (27%), Positives = 86/192 (44%), Gaps = 28/192 (14%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPE-----------RG 503
++ DLN ++ G + GP+G GKS+ +++ + G +T R
Sbjct: 437 ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD 496
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKE-----YLDNVQLGHILERE 558
++ V Q P + T+ + + Y GRED + I + +D Q L E
Sbjct: 497 QIGIVEQEPVLFSTTIAENIRY--GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 559 GGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV-- 616
GG +SGG+KQR+A+AR P+ +LD TSA+ + E + K+
Sbjct: 555 GGGQ--------MSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQH 606
Query: 617 GITLFTVSHRKS 628
G T+ +V+HR S
Sbjct: 607 GHTIISVAHRLS 618
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/194 (25%), Positives = 82/194 (42%), Gaps = 21/194 (10%)
Query: 450 PNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRL-----------T 498
P+ VL L+ + G + G +GCGKS+ ++L + G++
Sbjct: 1091 PDSQVL-NGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNV 1149
Query: 499 KPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDN--VQLGHILE 556
+ R + V Q P + ++ D + Y D ++ + + + L + + L E
Sbjct: 1150 QFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYE 1209
Query: 557 REGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV 616
G Q LS GEKQR+A+AR P+ +LDE TSA+ + E + K
Sbjct: 1210 TNVGSQGSQ-----LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKA 1264
Query: 617 --GITLFTVSHRKS 628
G T ++HR S
Sbjct: 1265 REGRTCIVIAHRLS 1278
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 63.2 bits (152), Expect = 8e-10
Identities = 69/266 (25%), Positives = 118/266 (44%), Gaps = 35/266 (13%)
Query: 380 EMTRLAGFTARITELMQV----LKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIII 435
++T L FT R+ + ++ +NH Y +T+ + I+ P P GE+
Sbjct: 1138 QLTGLFQFTVRLASETEARFTSVERINH--YIKTLSLEAPARIKNKAPSPDWPQEGEVTF 1195
Query: 436 ADNIIKF-DHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFG 494
+ +++ +++PL +++ ++F ++ + I G G GKSSL L L L G
Sbjct: 1196 ENAEMRYRENLPL-------VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSG 1248
Query: 495 GRLT-----------KPERGKLFYVPQRPYMTLGTLRDQVI-YPDGREDQKRKGISDLVL 542
G + R KL +PQ P + GT+R + + EDQ + +
Sbjct: 1249 GCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHM 1308
Query: 543 KEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVS 602
KE + QL LE E V + D S GE+Q + +AR + ILDE T+A+
Sbjct: 1309 KECI--AQLPLKLESE-----VMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMD 1361
Query: 603 VDVEGYIYSHCRK--VGITLFTVSHR 626
+ + I R+ T+ T++HR
Sbjct: 1362 TETDLLIQETIREAFADCTMLTIAHR 1387
Score = 58.9 bits (141), Expect = 1e-08
Identities = 45/164 (27%), Positives = 78/164 (47%), Gaps = 24/164 (14%)
Query: 456 IRDLNFEVRSGANVLICGPNGCGKSSLFR-VLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
+ ++ E++ G V ICG G GK+SL +LG++ L G G YV Q+ ++
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAIS---GTFAYVAQQAWI 634
Query: 515 TLGTLRDQVIYPDGREDQKRKGI-------SDLVLKEYLDNVQLGHILEREGGWDSVQDW 567
TLRD +++ ++++ + DL + D ++G ER
Sbjct: 635 LNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG---ERGAN------- 684
Query: 568 MDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYS 611
LSGG++QR+++AR Y ILD+ SA+ V +I++
Sbjct: 685 ---LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFN 725
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/180 (29%), Positives = 84/180 (46%), Gaps = 13/180 (7%)
Query: 460 NFEVRSGANVLICGPNGCGKSSLFRVL-GELWPLFGGRLTKPERGKLFYVPQRPYMTLGT 518
+ EV+ G V I G GCGKSSL + GEL L G + Q P++ T
Sbjct: 592 HLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFAT 651
Query: 519 LRDQVIYPDGREDQKRKGISDL-VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQ 577
+RD +++ + Q K + + L + L + G + E G V LSGG++
Sbjct: 652 IRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGD--QTEVGEKGV-----TLSGGQRA 704
Query: 578 RMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYL 637
R+A+AR Y + + +LD+ +AV DV ++ C +G+ +T + L H YL
Sbjct: 705 RIALARAVYQEKELYLLDDPLAAVDADVANHLLHRC-ILGMLSYTT---RLLCTHRTEYL 760
Score = 52.0 bits (123), Expect = 2e-06
Identities = 53/202 (26%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 440 IKFDHVPLA-TPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRL- 497
++F V LA P + + F V+ G + I G G GKSSL VL L GR+
Sbjct: 1218 VEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVL 1277
Query: 498 ----------TKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLD 547
R +L +PQ P++ GT+R+ + P G D L + L
Sbjct: 1278 LDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVREN-LDPQGLH-------KDRALWQALK 1329
Query: 548 NVQLGHILEREGGWD-SVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVE 606
L ++ GG D + + LS G++Q + +AR + +DE T++V +
Sbjct: 1330 QCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD 1389
Query: 607 GYI-YSHCRK-VGITLFTVSHR 626
+ + C++ T+ T++HR
Sbjct: 1390 QLLQQTICKRFANKTVLTIAHR 1411
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 59.7 bits (143), Expect = 8e-09
Identities = 49/192 (25%), Positives = 90/192 (46%), Gaps = 17/192 (8%)
Query: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPE-----------RG 503
+ +D + + SG+ + GP+G GKS++ +L L+ G ++ R
Sbjct: 509 IFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRS 568
Query: 504 KLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDS 563
K+ V Q P + ++ + + Y G +D ++ + N + I G+++
Sbjct: 569 KIGTVSQEPILFSCSIAENIAY--GADDPSSVTAEEIQRVAEVANA-VAFIRNFPQGFNT 625
Query: 564 VQDWMDVL-SGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKV--GITL 620
V VL SGG+KQR+A+AR P+ +LDE TSA+ + E + ++ G T+
Sbjct: 626 VVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTV 685
Query: 621 FTVSHRKSLWKH 632
++HR S K+
Sbjct: 686 LVIAHRLSTIKN 697
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/240 (26%), Positives = 111/240 (46%), Gaps = 38/240 (15%)
Query: 409 TMVSQQEKG-IEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGA 467
TM S+ +G ++ QV P GEI I D +++++ N +++ + ++ G
Sbjct: 1251 TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN------NLKPVLKHVKAYIKPGQ 1304
Query: 468 NVLICGPNGCGKSSLFRVLGELWPLFGGRLT-----------KPERGKLFYVPQRPYMTL 516
V ICG G GKSSL + +F G++ R +L + Q P +
Sbjct: 1305 KVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFS 1364
Query: 517 GTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILER-EGGWDSV-QDWMDVLSGG 574
G++R + D + K D L E L+ QL ++++ GG D+V + + S G
Sbjct: 1365 GSIRFNL-------DPECKCTDDR-LWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVG 1416
Query: 575 EKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLF------TVSHRKS 628
++Q +AR F K I+DE T+++ + E + +KV +T F T++HR S
Sbjct: 1417 QRQLFCLARAFVRKSSILIMDEATASIDMATENIL----QKVVMTAFADRTVVTIAHRVS 1472
Score = 57.8 bits (138), Expect = 3e-08
Identities = 52/214 (24%), Positives = 95/214 (44%), Gaps = 36/214 (16%)
Query: 451 NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLF-RVLGELWPLFG----GRLTKPE---- 501
+G + +++ + +G +I G GCGKSSL +LGE+ L G + + E
Sbjct: 647 SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFE 706
Query: 502 ------RGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLV-LKEYLDNVQLGHI 554
R + Y Q+P++ T+ + + + Q+ K ++D L+ +D + G
Sbjct: 707 ATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGD- 765
Query: 555 LEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCR 614
+ E G + LSGG++QR+ +AR Y LD+ SA+ + ++ H
Sbjct: 766 -QTEIGERGIN-----LSGGQRQRICVARALYQNTNIVFLDDPFSALDI----HLSDHLM 815
Query: 615 KVGI---------TLFTVSHRKSLWKHHEYYLHM 639
+ GI TL V+H+ H ++ + M
Sbjct: 816 QEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAM 849
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,243,678
Number of Sequences: 37866
Number of extensions: 997837
Number of successful extensions: 2393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2165
Number of HSP's gapped (non-prelim): 162
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.