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Search of human proteins with 4504385
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
(826 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 1655 0.0
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 1473 0.0
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 612 e-175
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 403 e-112
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 402 e-112
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 339 5e-93
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 275 1e-73
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 275 1e-73
gi|21614542 single-minded homolog 1 [Homo sapiens] 269 7e-72
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 247 3e-65
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 240 4e-63
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 212 1e-54
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 137 4e-32
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 137 4e-32
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 137 4e-32
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 137 5e-32
gi|4758010 clock [Homo sapiens] 129 1e-29
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 129 1e-29
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 128 2e-29
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 127 6e-29
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 123 6e-28
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 121 2e-27
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 90 7e-18
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 75 2e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 74 4e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 74 4e-13
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 74 4e-13
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 74 7e-13
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 69 2e-11
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 69 2e-11
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 1655 bits (4287), Expect = 0.0
Identities = 826/826 (100%), Positives = 826/826 (100%)
Query: 1 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
Sbjct: 1 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
Query: 61 RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
Sbjct: 61 RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
Sbjct: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
Query: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
Sbjct: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
Query: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
Sbjct: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
Query: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
Sbjct: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
Query: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
Sbjct: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
Query: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
Sbjct: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
Query: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
Sbjct: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
Query: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
Sbjct: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
Query: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
Sbjct: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
Query: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
Sbjct: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
Query: 721 KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC 780
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
Sbjct: 721 KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC 780
Query: 781 RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN 826
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
Sbjct: 781 RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN 826
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 1473 bits (3814), Expect = 0.0
Identities = 734/734 (100%), Positives = 734/734 (100%)
Query: 1 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
Sbjct: 1 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
Query: 61 RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
Sbjct: 61 RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
Sbjct: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
Query: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
Sbjct: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
Query: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
Sbjct: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
Query: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
Sbjct: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
Query: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
Sbjct: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
Query: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
Sbjct: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
Query: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
Sbjct: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
Query: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
Sbjct: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
Query: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
Sbjct: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
Query: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
Sbjct: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
Query: 721 KMEHDGSLFQAVGI 734
KMEHDGSLFQAVGI
Sbjct: 721 KMEHDGSLFQAVGI 734
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 612 bits (1577), Expect = e-175
Identities = 377/834 (45%), Positives = 504/834 (60%), Gaps = 103/834 (12%)
Query: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
+KK+ SSERRKEKSRDAAR RRSKE+EVFYELAH+LPLPH+VSSHLDKAS+MRL IS+LR
Sbjct: 6 EKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR 65
Query: 69 VRKLLDAGDLDIEDDMKA--QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
KLL + + E + +A QM+ YLKAL+GF+ V+T DGDMI++S+N++K+MGLTQ E
Sbjct: 66 THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVE 125
Query: 127 LTGHSVFDFTHPCDHEEMREMLTHRNG--LVKKGKEQNTQRSFFLRMKCTLTSRGRTMNI 184
LTGHS+FDFTHPCDHEE+RE L+ +NG KK K+ +T+R FF+RMKCT+T+RGRT+N+
Sbjct: 126 LTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNL 185
Query: 185 KSATWKVLHCTGHIHVYDT-NSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFL 243
KSATWKVLHCTG + VY+ + CGYK+P ++CL+++CEPI HPS+++IPLDSKTFL
Sbjct: 186 KSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
Query: 244 SRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTG 303
SRHS+DMKF+YCD+RITEL+GY PEELLGRS YE+YHALDS+++TK+H ++ TKGQV +G
Sbjct: 246 SRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSG 305
Query: 304 QYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
QYRMLAK GGYVW+ETQ TVIYN +N QPQCI+CVNYV+S I ++D++FS+ QTE + KP
Sbjct: 306 QYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP 365
Query: 364 VESSDMKMTQLFTK----VESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE 419
M M +F SE ++ LF KLK+EP+ L LAP GD IISLDFG
Sbjct: 366 ---HLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFG----- 417
Query: 420 TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLE 479
+Q EE Y +LP P+ LRS + Q A L
Sbjct: 418 --NQNFEESSAYGKAILP----------------PSQPWATELRSHS----TQSEAGSLP 455
Query: 480 PNPESLELSFTMPQ-IQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEK 538
+FT+PQ + +PS S+ S PNSP +Y +D+D+ K+E++EK
Sbjct: 456 --------AFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDL----KIEVIEK 503
Query: 539 LFAEDTEAKNPFSTQD--TDLDLEMLAPYIPMD-DDFQLRSFDQLSPLESSSASPESASP 595
LFA DTEAK+ STQ +LDLE LAPYIPMD +DFQL + P E A ++P
Sbjct: 504 LFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQL---SPICPEERLLAENPQSTP 560
Query: 596 QSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSAT 655
Q + T I +P A + L + ++E K + I + S
Sbjct: 561 QHCFSA--MTNIFQPLA---PVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKA 615
Query: 656 SSPYRDTQSRTASPNRAGKGVI-------------------EQTE--KSHPRSPNVLSVA 694
S P Q+ T + G+ ++TE + P P V
Sbjct: 616 SLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPH 675
Query: 695 LSQRTTVP--------EEELNPKILALQNAQR-KRKMEHDGSLFQAVGIGTLLQQPDDHA 745
+S T + L+P ++AL N + KR++E++ FQ + G
Sbjct: 676 VSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGG-----DPPGG 730
Query: 746 ATTSLSWKRVKGCKSSEQNGMEQKTIIL-IPSDL----ACRLLGQSMDESGLPQ 794
+T+ L WKR+K + M K + +P+D R LG + LPQ
Sbjct: 731 STSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQ 784
Score = 63.2 bits (152), Expect = 1e-09
Identities = 31/49 (63%), Positives = 36/49 (73%)
Query: 776 SDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQ 824
S +A RLLG S + LP+LT YDCEVN P+ GS LLQG +LLRALDQ
Sbjct: 820 SGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQ 868
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 403 bits (1035), Expect = e-112
Identities = 193/351 (54%), Positives = 261/351 (74%), Gaps = 2/351 (0%)
Query: 10 KKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV 69
+ + ++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+
Sbjct: 7 RARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 66
Query: 70 RKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
+L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL G
Sbjct: 67 HRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATW 189
HS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATW
Sbjct: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186
Query: 190 KVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHS 247
KVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHS
Sbjct: 187 KVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHS 246
Query: 248 LDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRM 307
LDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR
Sbjct: 247 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRF 306
Query: 308 LAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 307 LARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
Score = 53.5 bits (127), Expect = 8e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 376 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 435
Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 436 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 489
Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 490 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 549
Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 550 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 402 bits (1034), Expect = e-112
Identities = 193/347 (55%), Positives = 259/347 (74%), Gaps = 2/347 (0%)
Query: 14 SSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLL 73
++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+ +L
Sbjct: 9 TTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC 68
Query: 74 DAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVF 133
AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL GHS+F
Sbjct: 69 AAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIF 128
Query: 134 DFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLH 193
DF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATWKVL+
Sbjct: 129 DFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLN 188
Query: 194 CTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMK 251
C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHSLDMK
Sbjct: 189 CSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMK 248
Query: 252 FSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKR 311
F+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR LA+
Sbjct: 249 FTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARS 308
Query: 312 GGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
Score = 53.5 bits (127), Expect = 8e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 374 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 433
Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 434 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 487
Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 488 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 547
Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 548 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 598
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 339 bits (870), Expect = 5e-93
Identities = 161/301 (53%), Positives = 220/301 (73%), Gaps = 2/301 (0%)
Query: 60 MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY 119
MRLTISYLR+ +L AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K+
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
Query: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG 179
+GL+Q EL GHS+FDF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRG
Sbjct: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
Query: 180 RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPL 237
RT+N+K+ATWKVL+C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
Query: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
FLSRHSLDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +K
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
Query: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
GQ TGQYR LA+ GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QT
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
Query: 358 E 358
E
Sbjct: 301 E 301
Score = 53.5 bits (127), Expect = 8e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 320 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 379
Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 380 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 433
Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 434 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 493
Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 494 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 544
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 275 bits (703), Expect = 1e-73
Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
KEKS++AA++RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 79 DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
D D + ++ L+ LDGFV V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
+S++++ HP DH+EM +LT L +E +RSFFLRMKC L R +
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179
Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
+KV+HC+G++ + Y + + Y+ + LV + + +P + EI L S F+ R
Sbjct: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236
Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
SLD+K + D R+TE+ GYEP++L+ +++Y + H D HL HH + KGQVTT YR
Sbjct: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296
Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
+L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I +L SL+Q + +S
Sbjct: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352
Query: 367 SDMKMTQLFTKVES 380
D T L T E+
Sbjct: 353 QDSWRTALSTSQET 366
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 275 bits (703), Expect = 1e-73
Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
KEKS++AA++RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 79 DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
D D + ++ L+ LDGFV V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
+S++++ HP DH+EM +LT L +E +RSFFLRMKC L R +
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179
Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
+KV+HC+G++ + Y + + Y+ + LV + + +P + EI L S F+ R
Sbjct: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236
Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
SLD+K + D R+TE+ GYEP++L+ +++Y + H D HL HH + KGQVTT YR
Sbjct: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296
Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
+L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I +L SL+Q + +S
Sbjct: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352
Query: 367 SDMKMTQLFTKVES 380
D T L T E+
Sbjct: 353 QDSWRTALSTSQET 366
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 269 bits (688), Expect = 7e-72
Identities = 149/370 (40%), Positives = 221/370 (59%), Gaps = 18/370 (4%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG-- 76
KEKS++AAR+RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 77 -------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
D++ ++ L+ LDGF+ V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
Query: 130 HSVFDFTHPCDHEEMREMLT-HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
+S++++ HP DH+EM +LT H+ +E +RSFFLRMKC L R +
Sbjct: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
+KV+HC+G++ + Y + + Y+ LV + +P + EI L S F+ R
Sbjct: 180 YKVIHCSGYLKIRQYSLDMSPFDGCYQN---VGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
SLDMK + D R+ EL GYEP++L+ +++Y + H D+ HL HH + KGQVTT YR
Sbjct: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
LAK GG+VWV++ AT+++N+++S+P CIV VNYV++ L SL Q KP S
Sbjct: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIS-ASKPAFS 355
Query: 367 SDMKMTQLFT 376
T T
Sbjct: 356 YTSSSTPTMT 365
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 247 bits (631), Expect = 3e-65
Identities = 153/430 (35%), Positives = 234/430 (54%), Gaps = 70/430 (16%)
Query: 18 RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
RKEKSRDAARSRR KE+ FYELA LPLP ++S LDKAS++RLTISYL++R + GD
Sbjct: 22 RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
Query: 78 ----LDIE----------------------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 111
L +E + +A + L++LDGFV L +G +Y
Sbjct: 82 PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
Query: 112 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR----NGLVKKGKEQN----- 162
IS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L + GL+ +G ++
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
Query: 163 -------------------------TQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGH 197
+RSFF+RMK TLT RG ++IKS+ +KV+H TG
Sbjct: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITGR 259
Query: 198 IHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCD 256
+ + + S+ G P LV++ +P P+ E+ +D F++R ++D+ YC+
Sbjct: 260 LRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCE 315
Query: 257 ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVW 316
RI++ M P +++G+ Y + HA D + + +H D+ KGQ T YR + K GGY+W
Sbjct: 316 NRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIW 375
Query: 317 VETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFT 376
+++ AT+ N KN+ + I+ VNY++S D + Q + P ++S+ T +
Sbjct: 376 IQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL--PEKTSESSETS-DS 432
Query: 377 KVESEDTSSL 386
+ +S+DTS +
Sbjct: 433 ESDSKDTSGI 442
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 240 bits (612), Expect = 4e-63
Identities = 153/449 (34%), Positives = 234/449 (52%), Gaps = 89/449 (19%)
Query: 18 RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
RKEKSRDAARSRR KE+ FYELA LPLP ++S LDKAS++RLTISYL++R + GD
Sbjct: 22 RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
Query: 78 ----LDIE-----------------------------------------DDMKAQMNCFY 92
L +E + +A +
Sbjct: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
Query: 93 LKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR- 151
L++LDGFV L +G +YIS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L +
Sbjct: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
Query: 152 ---NGLVKKGKEQN------------------------------TQRSFFLRMKCTLTSR 178
GL+ +G ++ +RSFF+RMK TLT R
Sbjct: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
Query: 179 GRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPL 237
G ++IKS+ +KV+H TG + + + S+ G P LV++ +P P+ E+ +
Sbjct: 262 G--VHIKSSGYKVIHITGRLRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRI 315
Query: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
D F++R ++D+ YC+ RI++ M P +++G+ Y + HA D + + +H D+ K
Sbjct: 316 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 375
Query: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
GQ T YR + K GGY+W+++ AT+ N KN+ + I+ VNY++S D + Q
Sbjct: 376 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 435
Query: 358 ECVLKPVESSDMKMTQLFTKVESEDTSSL 386
+ P ++S+ T ++ +S+DTS +
Sbjct: 436 PHL--PEKTSESSETS-DSESDSKDTSGI 461
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 212 bits (540), Expect = 1e-54
Identities = 131/379 (34%), Positives = 197/379 (51%), Gaps = 69/379 (18%)
Query: 17 RRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG 76
+RKEKSR+AARSRR KE+ F+ELA LPLP +SS LDKAS++RL+++YLR+R+ G
Sbjct: 45 QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104
Query: 77 DLD----------------------IEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
+ + + + L++LDGFV L +G +YIS+
Sbjct: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164
Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN---------------------- 152
V+ Y+GL+Q E+TG SVFD+ HP DH E+ E L R
Sbjct: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224
Query: 153 -------GLVKKGKEQNTQ-RSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTN 204
L K Q RSFF+RMK TLT RG +++K++ +KV+H TG + +
Sbjct: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG 282
Query: 205 SNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMG 264
LV + +P E+PL + R SL + C+ R+++ M
Sbjct: 283 ---------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMD 327
Query: 265 YEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVI 324
P EL+GRS Y++ H D+ + ++H D+ KGQV TG YR L + GG+VW+++ ATV
Sbjct: 328 LGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVA 387
Query: 325 YNTKNSQPQCIVCVNYVVS 343
+ K+ ++ V++V+S
Sbjct: 388 GSGKSPGEHHVLWVSHVLS 406
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 137 bits (345), Expect = 4e-32
Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
+E + RR K + ELA +P + +S LDK +V+R+ + +++ L A +
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 88
Query: 79 DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
E + K ++ L+A DGF+ V+ D G ++++S++V K + +Q +L G S
Sbjct: 89 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 148
Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
+FD+ HP D +++E L+ R L+ K G T +RSFF RM
Sbjct: 149 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 208
Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
KC S + + S K +H TG++ + D + C
Sbjct: 209 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 266
Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
++CLV I +P P N EI + S ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 267 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323
Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
LLG S YEY+H D HL + H + T+ ++TT Y+ K G ++ + ++ N
Sbjct: 324 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 383
Query: 329 NSQPQCIVCVNYVV 342
+ + IV N VV
Sbjct: 384 TKEVEYIVSTNTVV 397
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 137 bits (345), Expect = 4e-32
Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
+E + RR K + ELA +P + +S LDK +V+R+ + +++ L A +
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131
Query: 79 DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
E + K ++ L+A DGF+ V+ D G ++++S++V K + +Q +L G S
Sbjct: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191
Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
+FD+ HP D +++E L+ R L+ K G T +RSFF RM
Sbjct: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251
Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
KC S + + S K +H TG++ + D + C
Sbjct: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309
Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
++CLV I +P P N EI + S ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
LLG S YEY+H D HL + H + T+ ++TT Y+ K G ++ + ++ N
Sbjct: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426
Query: 329 NSQPQCIVCVNYVV 342
+ + IV N VV
Sbjct: 427 TKEVEYIVSTNTVV 440
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 137 bits (345), Expect = 4e-32
Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)
Query: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
+E + RR K + ELA +P + +S LDK +V+R+ + +++ L A +
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131
Query: 79 DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
E + K ++ L+A DGF+ V+ D G ++++S++V K + +Q +L G S
Sbjct: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191
Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
+FD+ HP D +++E L+ R L+ K G T +RSFF RM
Sbjct: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251
Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
KC S + + S K +H TG++ + D + C
Sbjct: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309
Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
++CLV I +P P N EI + S ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366
Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
LLG S YEY+H D HL + H + T+ ++TT Y+ K G ++ + ++ N
Sbjct: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426
Query: 329 NSQPQCIVCVNYVV 342
+ + IV N VV
Sbjct: 427 TKEVEYIVSTNTVV 440
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 137 bits (344), Expect = 5e-32
Identities = 110/385 (28%), Positives = 193/385 (50%), Gaps = 46/385 (11%)
Query: 3 GAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRL 62
G+ + + ++ + +E + RR K + + EL+ +P + ++ LDK +V+R+
Sbjct: 93 GSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRM 152
Query: 63 TISYLRVRKLLDAGDLD-------IEDDMKAQMNCFYLKALDGFVMVL-TDDGDMIYISD 114
+ +LR K L + ++D+ ++ LK +GF+ V+ + G ++++S
Sbjct: 153 AVQHLRSLKGLTNSYVGSNYRPSFLQDN---ELRHLILKTAEGFLFVVGCERGKILFVSK 209
Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTH-----RNGLV--KKGKE------- 160
+V+K + Q LTG S+FDF HP D +++E L+ R L+ K G +
Sbjct: 210 SVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHA 269
Query: 161 ------QNTQRSFFLRMK-CTLTSR---GRTMNIKSATWK---VLHCTGHIHVYDTN--S 205
++RSFF R+K C ++ + G N K + +HCTG++ + N
Sbjct: 270 GRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVG 329
Query: 206 NQPQCGYKKPP--MTCLVLI--CEPIPHPSNI-EIPLDSKTFLSRHSLDMKFSYCDERIT 260
+ + KK TCLV I +P P N EI + F++R +++ KF Y D+R T
Sbjct: 330 MEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRAT 389
Query: 261 ELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVET 319
++GY P+ELLG S YEY+H D ++LT H + +K ++ T Y+ AK G +V +++
Sbjct: 390 AILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKS 449
Query: 320 QATVIYNTKNSQPQCIVCVNYVVSG 344
Q N + + IV VN +V G
Sbjct: 450 QWFSFTNPWTKELEYIVSVNTLVLG 474
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 129 bits (324), Expect = 1e-29
Identities = 101/362 (27%), Positives = 170/362 (46%), Gaps = 43/362 (11%)
Query: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
DK K S + EK R R + + + EL LP + +DK++V++ +I +LR
Sbjct: 32 DKAKRVSRNKSEKKR------RDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLR 82
Query: 69 VRKLLDAGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
K + A +I D K + L+ALDGF + + DG +IY+S++V +
Sbjct: 83 KHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLL 142
Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREML-TH---RNGLVKKGKEQNTQRSFFLRMKCTLT 176
+L S+F+F +H E+ ++L TH + L + + Q F C
Sbjct: 143 EHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEF-----CCHM 197
Query: 177 SRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYK-------------KPPMTCLVLI 223
RG + +T++ + G+ ++ S+ G++ + V +
Sbjct: 198 LRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRL 257
Query: 224 CEP--IPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHA 281
P I +E P ++ F SRHSL+ KF + D R ++GY P E+LG S Y+YYH
Sbjct: 258 ATPQFIKEMCTVEEP--NEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHV 315
Query: 282 LDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYV 341
D ++L K H + G+ + YR L K ++W++T + Y+ NS+P+ IVC + V
Sbjct: 316 DDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375
Query: 342 VS 343
VS
Sbjct: 376 VS 377
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 129 bits (323), Expect = 1e-29
Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 62/387 (16%)
Query: 7 ANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY 66
+NDK++ + E E R RR+K + EL+ +P ++ DK +++R+ +S+
Sbjct: 68 SNDKERFARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 123
Query: 67 LRVRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKY 119
++ L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V
Sbjct: 124 MK--SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181
Query: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT---- 163
+ Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241
Query: 164 ---QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY- 201
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301
Query: 202 ----DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFS 253
+ P+ G + CLV I P+ +++ F+SRH+++ F+
Sbjct: 302 PAGVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359
Query: 254 YCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRG 312
+ D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K
Sbjct: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
Query: 313 GYVWVETQATVIYNTKNSQPQCIVCVN 339
++W+ T + N + + + I+C N
Sbjct: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 128 bits (322), Expect = 2e-29
Identities = 132/523 (25%), Positives = 223/523 (42%), Gaps = 73/523 (13%)
Query: 16 ERRKEKSRDAARSRRSKESEVFY-ELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
+R K SR+ + +R + V EL+ LP + +DK +V+ I +L+ +
Sbjct: 7 DRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEVS 63
Query: 75 AGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
A DI+ D K + L+ALDGF++ +T DG +IY+SD++ +G +
Sbjct: 64 AQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSD 123
Query: 127 LTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKS 186
+ ++ +F +H E+ ++L+ + + + L C L RG +
Sbjct: 124 VMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEF 182
Query: 187 ATWKVLHCTGHIHVYDTNSNQPQC-GY-------------KKPPMTCLVLICEP--IPHP 230
T++ + G+ Y+ N P C G+ K+ V + P +
Sbjct: 183 PTYEYIKFVGNFRSYN-NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEM 241
Query: 231 SNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKT 290
++ PL+ F SRHSL+ KF + D R ++GY P E+LG S Y+YYH D + L +
Sbjct: 242 CIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARC 299
Query: 291 HHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL 350
H + G+ + YR L K ++W++T + Y+ NS+P+ IVC + VVS D+
Sbjct: 300 HQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS---YADV 356
Query: 351 IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIIS 410
+Q E L+ S + + L K S + F+ +
Sbjct: 357 RVERRQ-ELALEDPPSEALHSSALKDKGSSLEPRQHFN---------------------T 394
Query: 411 LDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPAL 470
LD G++ T S ++ + AMS PT+ K + ++ PAL
Sbjct: 395 LDVGASGLNTSHSP-----------SASSRSSHKSSHTAMSE-PTSTPTKLMAEASTPAL 442
Query: 471 NQEVALKLEPNPESLELSFTMPQIQDQTPSPSD-GSTRQSSPE 512
+ L E L + TMP PSPS T+Q P+
Sbjct: 443 PRSATLPQELPVPGLSQAATMPA---PLPSPSSCDLTQQLLPQ 482
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 127 bits (318), Expect = 6e-29
Identities = 98/385 (25%), Positives = 182/385 (47%), Gaps = 62/385 (16%)
Query: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
DK++++ E E R RR+K + EL+ +P ++ DK +++R+ +S+++
Sbjct: 85 DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
Query: 69 VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V +
Sbjct: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
Query: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT------ 163
Q E G +++D HP D +++RE L+ + G VKK +Q++
Sbjct: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Query: 164 -QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY--- 201
+RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318
Query: 202 --DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYC 255
+ P+ G + CLV I P+ +++ F+SRH+++ F++
Sbjct: 319 GVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376
Query: 256 DERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGY 314
D R +GY+P+ELLG++I E+ H D L + + KGQV + +R +K +
Sbjct: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
Query: 315 VWVETQATVIYNTKNSQPQCIVCVN 339
+W+ T + N + + + I+C N
Sbjct: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 123 bits (309), Expect = 6e-28
Identities = 105/405 (25%), Positives = 182/405 (44%), Gaps = 72/405 (17%)
Query: 15 SERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
S+ +E + R RR+K ++ EL+ +P ++ DK +++R+ +S+++ +
Sbjct: 61 SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--SMRG 118
Query: 75 AGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMGLTQFEL 127
G+ + K ++ L+A DGF+ V+ + G +IY+SD+V + Q E
Sbjct: 119 TGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
Query: 128 TGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT-------QRSFF 168
G ++++ HP D E++RE L + G VKK +Q++ +RSF
Sbjct: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
Query: 169 LRMKC------------TLTSRGRTMN----IKS--ATWKVLHCTGHIHVYDTNSNQPQC 210
RM+C T R R N +K A + V+HCTG+I + P
Sbjct: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW------PPA 292
Query: 211 GYKKPPMT---------CLVLI------CEPIPHPSN-IEIPLDSKTFLSRHSLDMKFSY 254
G P CLV I P+ N + +P + FLSRH+ D ++
Sbjct: 293 GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLSRHNSDGIITF 349
Query: 255 CDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGG 313
D R ++GY+P++LLG+ I E+ H D HL ++ + KGQV + YR K
Sbjct: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409
Query: 314 YVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
++ + T + N + + + I+C N V + Q + Q +
Sbjct: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRD 454
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 121 bits (304), Expect = 2e-27
Identities = 97/370 (26%), Positives = 160/370 (43%), Gaps = 57/370 (15%)
Query: 11 KKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR 70
K I +E K R R + E + LA LP P +V + LDK SV+RL++SYLR +
Sbjct: 24 KPIPAEGIKSNPSKRHRDRLNTELD---RLASLLPFPQDVINKLDKLSVLRLSVSYLRAK 80
Query: 71 KLLDAG----------------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
D + + + Q F L+AL+GFV+V+T D + Y S
Sbjct: 81 SFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS 140
Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREML---THRNGLVKKGK--EQNT------ 163
+ Y+G Q ++ SV++ H D E + L + + + G+ E+ T
Sbjct: 141 TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTV 200
Query: 164 ----------------QRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQ 207
+R F R++C L + S+ + ++ G + +
Sbjct: 201 VCYNPDQIPPENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKK 252
Query: 208 PQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP 267
+ G PP L I P+ PS +EI + F ++H LD CD + ++GY
Sbjct: 253 GKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTE 312
Query: 268 EELLGR-SIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYN 326
EL R S Y++ HA D + ++H M G+ +R+L K + WV++ A ++Y
Sbjct: 313 AELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY- 371
Query: 327 TKNSQPQCIV 336
KN +P I+
Sbjct: 372 -KNGRPDYII 380
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 90.1 bits (222), Expect = 7e-18
Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)
Query: 22 SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81
++ A+++RR + + L LPL L +M L Y R + + AG +
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63
Query: 82 DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136
+ AQ + AL GF++V T +G ++Y+S++V++++G + +L G S++D
Sbjct: 64 GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
Query: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196
P DH +R+ LT + L +T R F R + +++ +SA K++ G
Sbjct: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171
Query: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250
H + P Y P T EP P P P + FL SRH+ D+
Sbjct: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225
Query: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308
E + +G+E ELL +S Y H D H + H+ + + + R+
Sbjct: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285
Query: 309 AKRGGYVWV 317
AK GG+ W+
Sbjct: 286 AKTGGWAWI 294
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 75.5 bits (184), Expect = 2e-13
Identities = 84/405 (20%), Positives = 172/405 (42%), Gaps = 63/405 (15%)
Query: 1 MEGAG-GANDKKKISSERRKE--------KSRDAARSRRSKESEVFYELAHQLPLPHNVS 51
M G G +D + + +RKE R+ + R +E++ ELA + N
Sbjct: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
Query: 52 SHL----DKASVMRLTISYLR-VRKLLDAGDLDIEDDMKAQMNC-------------FYL 93
+ DK ++++ T+ +R +++ A +I++ K+ ++ L
Sbjct: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
Query: 94 KALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR-- 151
+ALDGF V+ +G+++++S+NV +Y+ Q EL SV+ H DH E + L +
Sbjct: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
Query: 152 -NGLVKKGK-EQNTQRSFFLRMKC----TLTSRGRTMNIKSATWKVLHCTGHIHVYDTNS 205
NG G+ + +F RM G ++ + C
Sbjct: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA--------V 232
Query: 206 NQPQCGYKKPP--MTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELM 263
+QP+ ++ +CL+ + +P +P S++F +R L K + D T
Sbjct: 233 SQPKSIKEEGEDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRA 290
Query: 264 GYEP--EELLGRSIYEYYHALDSDHLT---KTHHDMFTKGQVTTGQYRMLAKRGGYVWVE 318
+P E+L+ R I +++ + + ++ + HH++ +G + YR G V +
Sbjct: 291 AMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQ 350
Query: 319 TQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
T++ +I + ++PQ ++ ++ + +Q CV+ P
Sbjct: 351 TKSKLIRSQTTNEPQLVISLH-----------MLHREQNVCVMNP 384
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 74.3 bits (181), Expect = 4e-13
Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)
Query: 1 MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
M G G ++D S +RK D S RR +E++ ELA L ++
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 51 SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
S DK +++ T+ +++ K ++ +DD+ K + L+AL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 97 DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
DGF V+ +G ++++S+NV Y+G Q EL SV+ H DH E + L + NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
+ + + +F RM T N ++ ++V+ C V S Q
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
+ +CL+ I +P P I ++F+++ K D G E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
+ + IY ++ + + + ++ T+G ++ YR + G + T+ + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 74.3 bits (181), Expect = 4e-13
Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)
Query: 1 MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
M G G ++D S +RK D S RR +E++ ELA L ++
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 51 SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
S DK +++ T+ +++ K ++ +DD+ K + L+AL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 97 DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
DGF V+ +G ++++S+NV Y+G Q EL SV+ H DH E + L + NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
+ + + +F RM T N ++ ++V+ C V S Q
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
+ +CL+ I +P P I ++F+++ K D G E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
+ + IY ++ + + + ++ T+G ++ YR + G + T+ + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 74.3 bits (181), Expect = 4e-13
Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)
Query: 1 MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
M G G ++D S +RK D S RR +E++ ELA L ++
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 51 SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
S DK +++ T+ +++ K ++ +DD+ K + L+AL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 97 DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
DGF V+ +G ++++S+NV Y+G Q EL SV+ H DH E + L + NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
+ + + +F RM T N ++ ++V+ C V S Q
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
+ +CL+ I +P P I ++F+++ K D G E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
+ + IY ++ + + + ++ T+G ++ YR + G + T+ + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 73.6 bits (179), Expect = 7e-13
Identities = 60/237 (25%), Positives = 112/237 (47%), Gaps = 50/237 (21%)
Query: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
DK++++ E E R RR+K + EL+ +P ++ DK +++R+ +S+++
Sbjct: 85 DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
Query: 69 VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
L G+ + K ++ L+A DGF+ +++ + G ++Y+SD+V +
Sbjct: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
Query: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQN------- 162
Q E G +++D HP D +++RE L+ + G VKK +Q+
Sbjct: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Query: 163 TQRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY 201
++RSF RM+C +S R R N +K + V+HCTG+I +
Sbjct: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 68.6 bits (166), Expect = 2e-11
Identities = 145/750 (19%), Positives = 277/750 (36%), Gaps = 81/750 (10%)
Query: 27 RSRRSKESEVFYELAHQLPLP----HNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIED 82
+ RR +ES+ ELA + N + DK ++++ T+ ++R++ + G D
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTISND 92
Query: 83 DM---------------KAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFEL 127
D K + L+ALDGF+ V+ DG+++++S+NV +Y+ Q +L
Sbjct: 93 DDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDL 152
Query: 128 TGHSVFDFTHPCDHEEMREMLTHR--NGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIK 185
SV++ H D ++ + L NG V E Q+S + + + +
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNG-VSWTNETQRQKSHTFNCRMLMKTPHDILEDI 211
Query: 186 SATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSR 245
+A+ ++ + + + + + +C++ + I P + ++F++R
Sbjct: 212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITR 270
Query: 246 HSLDMKFSYCD-ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHH--DMFTKGQVTT 302
H L K D + M E+++ R I ++ D ++ H + + G T
Sbjct: 271 HDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAET 330
Query: 303 GQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNY--------------VVSGIIQH 348
YR G V +T++ + N + V ++ V GI
Sbjct: 331 PVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPP 390
Query: 349 DLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG--- 405
+ + P + M ++ + + T + + L P G
Sbjct: 391 MAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQS 450
Query: 406 -DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRS 464
+ + ++G N + P ++M+ SP + + P A P+ S
Sbjct: 451 PSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMI-SPRNRGSPKIASHQFSPVAGVHSPMAS 509
Query: 465 SADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPS-DGSTRQSSPEP------NSPS 517
S + + + L E T +P P D S + +P +S S
Sbjct: 510 SGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKS 569
Query: 518 EYCFYVDSDMVNEFKLELVEKLFAEDTEAKNP----FSTQDTDLDL---EMLAPYIPMDD 570
FY D + V + + D E+K Q L+ + L +
Sbjct: 570 PLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSS 629
Query: 571 DFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD 630
D + S SPL+SS +S+V+V + + T+ ++T+ K
Sbjct: 630 DDRGHSSLTNSPLDSS-------CKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKH 682
Query: 631 RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSP-- 688
R+ K+L SP + K T AT +DT S T+ G G + + E+ P+
Sbjct: 683 RILH-KLLQNGNSPAEVAKITAEATG---KDTSSITS----CGDGNVVKQEQLSPKKKEN 734
Query: 689 NVLSVALSQR---TTVPEEELNPKILALQN 715
N L L R + +EL P++ + N
Sbjct: 735 NALLRYLLDRDDPSDALSKELQPQVEGVDN 764
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 68.6 bits (166), Expect = 2e-11
Identities = 145/750 (19%), Positives = 277/750 (36%), Gaps = 81/750 (10%)
Query: 27 RSRRSKESEVFYELAHQLPLP----HNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIED 82
+ RR +ES+ ELA + N + DK ++++ T+ ++R++ + G D
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTISND 92
Query: 83 DM---------------KAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFEL 127
D K + L+ALDGF+ V+ DG+++++S+NV +Y+ Q +L
Sbjct: 93 DDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDL 152
Query: 128 TGHSVFDFTHPCDHEEMREMLTHR--NGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIK 185
SV++ H D ++ + L NG V E Q+S + + + +
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNG-VSWTNETQRQKSHTFNCRMLMKTPHDILEDI 211
Query: 186 SATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSR 245
+A+ ++ + + + + + +C++ + I P + ++F++R
Sbjct: 212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITR 270
Query: 246 HSLDMKFSYCD-ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHH--DMFTKGQVTT 302
H L K D + M E+++ R I ++ D ++ H + + G T
Sbjct: 271 HDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAET 330
Query: 303 GQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNY--------------VVSGIIQH 348
YR G V +T++ + N + V ++ V GI
Sbjct: 331 PVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPP 390
Query: 349 DLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG--- 405
+ + P + M ++ + + T + + L P G
Sbjct: 391 MAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQS 450
Query: 406 -DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRS 464
+ + ++G N + P ++M+ SP + + P A P+ S
Sbjct: 451 PSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMI-SPRNRGSPKIASHQFSPVAGVHSPMAS 509
Query: 465 SADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPS-DGSTRQSSPEP------NSPS 517
S + + + L E T +P P D S + +P +S S
Sbjct: 510 SGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKS 569
Query: 518 EYCFYVDSDMVNEFKLELVEKLFAEDTEAKNP----FSTQDTDLDL---EMLAPYIPMDD 570
FY D + V + + D E+K Q L+ + L +
Sbjct: 570 PLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSS 629
Query: 571 DFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD 630
D + S SPL+SS +S+V+V + + T+ ++T+ K
Sbjct: 630 DDRGHSSLTNSPLDSS-------CKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKH 682
Query: 631 RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSP-- 688
R+ K+L SP + K T AT +DT S T+ G G + + E+ P+
Sbjct: 683 RILH-KLLQNGNSPAEVAKITAEATG---KDTSSITS----CGDGNVVKQEQLSPKKKEN 734
Query: 689 NVLSVALSQR---TTVPEEELNPKILALQN 715
N L L R + +EL P++ + N
Sbjct: 735 NALLRYLLDRDDPSDALSKELQPQVEGVDN 764
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,994,060
Number of Sequences: 37866
Number of extensions: 1551128
Number of successful extensions: 5984
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 5133
Number of HSP's gapped (non-prelim): 833
length of query: 826
length of database: 18,247,518
effective HSP length: 111
effective length of query: 715
effective length of database: 14,044,392
effective search space: 10041740280
effective search space used: 10041740280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.