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Search of human proteins with 4502003
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
(848 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 1741 0.0
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 298 1e-80
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 133 8e-31
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 129 1e-29
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 127 4e-29
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 127 4e-29
gi|21614542 single-minded homolog 1 [Homo sapiens] 122 2e-27
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 121 2e-27
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 121 2e-27
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 115 2e-25
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 107 5e-23
gi|4758010 clock [Homo sapiens] 99 2e-20
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 97 5e-20
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 97 5e-20
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 94 5e-19
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 94 5e-19
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 94 5e-19
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 86 1e-16
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 86 1e-16
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 79 2e-14
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 74 6e-13
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 71 5e-12
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 71 5e-12
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 70 1e-11
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 70 1e-11
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 70 1e-11
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 68 4e-11
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 65 3e-10
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 63 1e-09
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 63 1e-09
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 1741 bits (4508), Expect = 0.0
Identities = 848/848 (100%), Positives = 848/848 (100%)
Query: 1 MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV 60
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV
Sbjct: 1 MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV 60
Query: 61 INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ 120
INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ
Sbjct: 61 INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ 120
Query: 121 ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP 180
ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP
Sbjct: 121 ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP 180
Query: 181 SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ 240
SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ
Sbjct: 181 SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ 240
Query: 241 GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC 300
GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC
Sbjct: 241 GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC 300
Query: 301 DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW 360
DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW
Sbjct: 301 DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW 360
Query: 361 TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF 420
TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF
Sbjct: 361 TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF 420
Query: 421 PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP 480
PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP
Sbjct: 421 PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP 480
Query: 481 FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY 540
FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY
Sbjct: 481 FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY 540
Query: 541 SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ 600
SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ
Sbjct: 541 SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ 600
Query: 601 QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV 660
QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV
Sbjct: 601 QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV 660
Query: 661 PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP 720
PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP
Sbjct: 661 PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP 720
Query: 721 MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH 780
MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH
Sbjct: 721 MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH 780
Query: 781 THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP 840
THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP
Sbjct: 781 THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP 840
Query: 841 DLTSSGFL 848
DLTSSGFL
Sbjct: 841 DLTSSGFL 848
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 298 bits (764), Expect = 1e-80
Identities = 186/413 (45%), Positives = 238/413 (57%), Gaps = 51/413 (12%)
Query: 9 TYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLS 68
TYA RKRR+P+QK + AE KSNPSKRHRDRLN ELD LASLLPFP D+I+KLDKLS
Sbjct: 12 TYAGRKRRRPLQKQRPAVGAE--KSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLS 69
Query: 69 VLRLSVSYLRAKSFFDVALKSSPTERNGGQ----DNCRAANFREGLNLQEGEFLLQALNG 124
VLRLSVSYLR KSFF V + S + G D+C A G + EG LL++LNG
Sbjct: 70 VLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLA----GSAVLEGRLLLESLNG 125
Query: 125 FVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCT 184
F LVV+ + +FYAS+TI DYLGF Q+DV+HQ++Y+ IH +DR +F RQLHWA++P Q
Sbjct: 126 FALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVV 185
Query: 185 ESGQGIEEATGLPQTVVCYNPDQ-----IPPENSPLMERCFICRLRCLLDNSSGFLA--- 236
GQ TG + Q P E S + RCFICR+RCLLD++SGFLA
Sbjct: 186 -FGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGS 244
Query: 237 ---------------MNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIR 281
M FQGKLK+L GQKKK G++LPP+L+LF IA P+ PS E++
Sbjct: 245 QAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMK 304
Query: 282 TKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMI 341
++ + R K + D T DAK + E+EL + + Y A R
Sbjct: 305 MRSALLRAKPRAD-TAATADAKVKATTSLCESELHGKPN-----------YSAGRSSR-- 350
Query: 342 KTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEH 394
ESG++V R T RW V + A L G PD ++ + D E +H
Sbjct: 351 ---ESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQH 400
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 133 bits (334), Expect = 8e-31
Identities = 120/471 (25%), Positives = 203/471 (43%), Gaps = 58/471 (12%)
Query: 36 SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSF-------FDVALK 88
++ R + N E LA LLP P + ++LDK S++RL++SYL+ + F +++ ++
Sbjct: 30 ARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRME 89
Query: 89 SSP--TERNGGQDN-CRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDY 145
P T G Q +A E G +LQ+L+GFV + + Y S T+ Y
Sbjct: 90 GPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIY 149
Query: 146 LGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP-----SQCT----ESGQGIEEATGL 196
LG Q ++ SV++ +H D E QL L P SQ T S +
Sbjct: 150 LGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSET 209
Query: 197 PQTVVCYNPDQIPPENSPLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQK 250
P+ V +P + +N+ +ER F R++ L SSG+ ++ G+L+ +
Sbjct: 210 PEPVESTSPSLLTTDNT--LERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRL----R 263
Query: 251 KKGKDGSILPPQ-LALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLG 309
G +P Q + L +A L PP+I E+R +F T+ +D I C+ + +
Sbjct: 264 VSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMD 323
Query: 310 YTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARL 369
T ++ + Y FIHA D+ SH+ ++ G+ +R + KN + W+QS+A +
Sbjct: 324 LTPVDIVGKRC-YHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATI 382
Query: 370 L---------------YKNGRPDY----IIVTQRPLTDEEGTEHLRKRNTKLPFMFTTG- 409
Y P+Y + + Q P E+ +E +++ T+G
Sbjct: 383 AINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGI 442
Query: 410 -----EAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSS 455
+ E N DP P R K+G + + + S NP S
Sbjct: 443 TEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDS 493
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 129 bits (324), Expect = 1e-29
Identities = 120/490 (24%), Positives = 203/490 (41%), Gaps = 77/490 (15%)
Query: 36 SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFF------------ 83
++ R + N E LA LLP P + ++LDK S++RL++SYL+ + F
Sbjct: 30 ARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRME 89
Query: 84 ----------------DVALKSSPTERNGGQDN-CRAANFREGLNLQEGEFLLQALNGFV 126
++ ++ +P E G Q +A E G +LQ+L+GFV
Sbjct: 90 GPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 149
Query: 127 LVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP-----S 181
+ + Y S T+ YLG Q ++ SV++ +H D E QL L P S
Sbjct: 150 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 209
Query: 182 QCT----ESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLD------NS 231
Q T S + P+ V +P + +N+ +ER F R++ L S
Sbjct: 210 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNT--LERSFFIRMKSTLTKRGVHIKS 267
Query: 232 SGFLAMNFQGKLKYLHGQKKKGKDGSILPPQ-LALFAIATPLQPPSILEIRTKNFIFRTK 290
SG+ ++ G+L+ + G +P Q + L +A L PP+I E+R +F T+
Sbjct: 268 SGYKVIHITGRLRL----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTR 323
Query: 291 HKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIV 350
+D I C+ + + T ++ + Y FIHA D+ SH+ ++ G+
Sbjct: 324 VNMDLNIIYCENRISDYMDLTPVDIVGKRC-YHFIHAEDVEGIRHSHLDLLNKGQCVTKY 382
Query: 351 FRLLTKNNRWTWVQSNARLL---------------YKNGRPDY----IIVTQRPLTDEEG 391
+R + KN + W+QS+A + Y P+Y + + Q P E+
Sbjct: 383 YRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKT 442
Query: 392 TEHLRKRNTKLPFMFTTG------EAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTST 445
+E +++ T+G + E N DP P R K+G + + +
Sbjct: 443 SESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCND 502
Query: 446 LSKDSLNPSS 455
S NP S
Sbjct: 503 DGHSSSNPDS 512
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 127 bits (319), Expect = 4e-29
Identities = 101/368 (27%), Positives = 163/368 (44%), Gaps = 43/368 (11%)
Query: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTE 93
N +K R++ N E LA LLP P + ++LDK S++RL+ SYL+ ++ F L +
Sbjct: 7 NAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDA--- 63
Query: 94 RNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDV 153
GQ + A +G+ + G LLQ L+GFV VV +D + Y S T +LG Q ++
Sbjct: 64 --WGQPS--RAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVEL 119
Query: 154 IHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213
S+YE IH D E + + + P
Sbjct: 120 TGNSIYEYIHPSDHDE--------------------------MTAVLTAHQPLHHHLLQE 153
Query: 214 PLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFA 267
+ER F R++C+L SG+ ++ G LK S + L A
Sbjct: 154 YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCY-QIVGLVA 212
Query: 268 IATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHA 327
+ L P +I EI+ + +F + LD I D++ V GY +L + + Y +H
Sbjct: 213 VGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEK-TLYHHVHG 271
Query: 328 ADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVTQRP 385
D+ + +H ++ G+ +RLL+K W WVQS A +++ ++ RP I+
Sbjct: 272 CDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYV 331
Query: 386 LTDEEGTE 393
LT+ E E
Sbjct: 332 LTEIEYKE 339
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 127 bits (319), Expect = 4e-29
Identities = 101/368 (27%), Positives = 163/368 (44%), Gaps = 43/368 (11%)
Query: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTE 93
N +K R++ N E LA LLP P + ++LDK S++RL+ SYL+ ++ F L +
Sbjct: 7 NAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDA--- 63
Query: 94 RNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDV 153
GQ + A +G+ + G LLQ L+GFV VV +D + Y S T +LG Q ++
Sbjct: 64 --WGQPS--RAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVEL 119
Query: 154 IHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213
S+YE IH D E + + + P
Sbjct: 120 TGNSIYEYIHPSDHDE--------------------------MTAVLTAHQPLHHHLLQE 153
Query: 214 PLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFA 267
+ER F R++C+L SG+ ++ G LK S + L A
Sbjct: 154 YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCY-QIVGLVA 212
Query: 268 IATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHA 327
+ L P +I EI+ + +F + LD I D++ V GY +L + + Y +H
Sbjct: 213 VGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEK-TLYHHVHG 271
Query: 328 ADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVTQRP 385
D+ + +H ++ G+ +RLL+K W WVQS A +++ ++ RP I+
Sbjct: 272 CDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYV 331
Query: 386 LTDEEGTE 393
LT+ E E
Sbjct: 332 LTEIEYKE 339
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 122 bits (305), Expect = 2e-27
Identities = 95/368 (25%), Positives = 159/368 (43%), Gaps = 49/368 (13%)
Query: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS--P 91
N ++ R++ N+E LA LLP P + ++LDK S++RL+ SYL+ + F L +
Sbjct: 7 NAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGH 66
Query: 92 TERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQS 151
+ R DN + + G LLQ L+GF+ VV D + Y S T +LG Q
Sbjct: 67 SSRTSPLDN---------VGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQV 117
Query: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211
++ S+YE IH D E + + + P
Sbjct: 118 ELTGNSIYEYIHPADHDE--------------------------MTAVLTAHQPYHSHFV 151
Query: 212 NSPLMERCFICRLRCLLDNSS------GFLAMNFQGKLKY-LHGQKKKGKDGSILPPQLA 264
+ER F R++C+L + G+ ++ G LK + DG +
Sbjct: 152 QEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCY--QNVG 209
Query: 265 LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQF 324
L A+ L P ++ EI+ + +F + LD I D++ + GY +L + + Y
Sbjct: 210 LVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEK-TLYHH 268
Query: 325 IHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVT 382
+H D + +H ++ G+ +R L K+ W WVQS A +++ ++ RP I+
Sbjct: 269 VHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSV 328
Query: 383 QRPLTDEE 390
LTD E
Sbjct: 329 NYVLTDTE 336
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 121 bits (304), Expect = 2e-27
Identities = 97/370 (26%), Positives = 160/370 (43%), Gaps = 57/370 (15%)
Query: 24 KPIPAEGIKSNPSKRHRDRLNTELD---RLASLLPFPQDVINKLDKLSVLRLSVSYLRAK 80
K I +E K R R + E + LA LP P +V + LDK SV+RL++SYLR +
Sbjct: 11 KKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR 70
Query: 81 SFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS 140
D + + + Q F L+AL+GFV+V+T D + Y S
Sbjct: 71 KLLDAG----------------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
Query: 141 TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTV 200
+ Y+G Q ++ SV++ H D E + L + + + G+ E+ T
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREML---THRNGLVKKGK--EQNT------ 163
Query: 201 VCYNPDQIPPENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKK 252
+R F R++C L + S+ + ++ G + +
Sbjct: 164 ----------------QRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQ 207
Query: 253 GKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTE 312
+ G PP L I P+ PS +EI + F ++H LD CD + ++GY
Sbjct: 208 PQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP 267
Query: 313 AELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY- 371
EL R S Y++ HA D + ++H M G+ +R+L K + WV++ A ++Y
Sbjct: 268 EELLGR-SIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYN 326
Query: 372 -KNGRPDYII 380
KN +P I+
Sbjct: 327 TKNSQPQCIV 336
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 121 bits (304), Expect = 2e-27
Identities = 97/370 (26%), Positives = 160/370 (43%), Gaps = 57/370 (15%)
Query: 24 KPIPAEGIKSNPSKRHRDRLNTELD---RLASLLPFPQDVINKLDKLSVLRLSVSYLRAK 80
K I +E K R R + E + LA LP P +V + LDK SV+RL++SYLR +
Sbjct: 11 KKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR 70
Query: 81 SFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS 140
D + + + Q F L+AL+GFV+V+T D + Y S
Sbjct: 71 KLLDAG----------------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
Query: 141 TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTV 200
+ Y+G Q ++ SV++ H D E + L + + + G+ E+ T
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREML---THRNGLVKKGK--EQNT------ 163
Query: 201 VCYNPDQIPPENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKK 252
+R F R++C L + S+ + ++ G + +
Sbjct: 164 ----------------QRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQ 207
Query: 253 GKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTE 312
+ G PP L I P+ PS +EI + F ++H LD CD + ++GY
Sbjct: 208 PQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP 267
Query: 313 AELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY- 371
EL R S Y++ HA D + ++H M G+ +R+L K + WV++ A ++Y
Sbjct: 268 EELLGR-SIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYN 326
Query: 372 -KNGRPDYII 380
KN +P I+
Sbjct: 327 TKNSQPQCIV 336
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 115 bits (287), Expect = 2e-25
Identities = 108/430 (25%), Positives = 175/430 (40%), Gaps = 54/430 (12%)
Query: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTE 93
N ++ R + N E LA LLP P + ++LDK S++RLSV+YLR + F AL + P
Sbjct: 52 NAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRF--AALGAPPWG 109
Query: 94 RNGGQDNCRAANFREG--------LNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDY 145
A R G G +LQ+L+GFV + + Y S T+ Y
Sbjct: 110 LRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIY 169
Query: 146 LGFQQSDVIHQSVYELIHTEDRAEFQRQLHWAL------NPSQCTESGQGIEEATGLPQT 199
LG Q ++ SV++ IH D +E QL P + S P+
Sbjct: 170 LGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEI 229
Query: 200 VVCYNPDQIPPENSPLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQKKKG 253
++PP +S + ER F R++ L +SG+ ++ G+L+
Sbjct: 230 EASLT--KVPP-SSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLR--------- 277
Query: 254 KDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEA 313
L L A+ L P + E+ + + L T + C+++ + +
Sbjct: 278 ------AHALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
Query: 314 ELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKN 373
EL R S YQF+H D +SH+ ++ G+ +R L + + W+QS A +
Sbjct: 332 ELVGR-SCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSG 390
Query: 374 GRP--DYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRT 431
P +++ L+ EG + T L EA++P P +P P
Sbjct: 391 KSPGEHHVLWVSHVLSQAEGGQ------TPLDAFQLPASVACEEASSPGPEPTEPEP--- 441
Query: 432 KNGTSGKDSA 441
T GK +A
Sbjct: 442 --PTEGKQAA 449
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 107 bits (267), Expect = 5e-23
Identities = 91/371 (24%), Positives = 157/371 (42%), Gaps = 52/371 (14%)
Query: 32 KSNPSKRHRDRLNTELD-RLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
KS + R R TE+ LA LP P V + LDK S++RL++S+LR +
Sbjct: 18 KSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSEN 77
Query: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
+E Q Q L+AL GF+ VVT D + + S I ++G Q
Sbjct: 78 ESEAEADQ--------------QMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQ 123
Query: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
++ S+++ H D E + L ++G G + + T
Sbjct: 124 VELTGHSIFDFTHPCDHEEIRENLS--------LKNGSGFGKKSKDMST----------- 164
Query: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQ 262
ER F R++C + N S+ + ++ G++K + P
Sbjct: 165 ------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPL 218
Query: 263 LA-LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSG 321
L+ L + P+Q PS ++I + F ++H +D CD + ++GY EL R S
Sbjct: 219 LSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGR-SA 277
Query: 322 YQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYI 379
Y+F HA D +SH + G+ +R+L K+ + W+++ ++Y +N +P I
Sbjct: 278 YEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCI 337
Query: 380 IVTQRPLTDEE 390
+ L++ E
Sbjct: 338 MCVNYVLSEIE 348
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 98.6 bits (244), Expect = 2e-20
Identities = 87/355 (24%), Positives = 159/355 (44%), Gaps = 25/355 (7%)
Query: 32 KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSP 91
++ K+ RD+ N + L S+LP K+DK +VL+ S+ +LR ++ +S
Sbjct: 39 RNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHK--EITAQSDA 93
Query: 92 TE-RNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
+E R + + N + + +L+AL+GF L + TD + Y S ++ L
Sbjct: 94 SEIRQDWKPTFLS-------NEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLP 146
Query: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
SD++ QS++ I + +E + L L S + + ++ L P
Sbjct: 147 SDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL-TPEYLKSKNQLEFCCHMLRGTIDPK 205
Query: 211 ENSPLMERCFICRLRCLLDNSSGFLAMN-FQGKLKYLHGQKKKGKDGSILPPQLALFAIA 269
E S FI + L NS A N F+G ++ H + + + A +A
Sbjct: 206 EPSTYEYVKFIGNFKSL--NSVSSSAHNGFEGTIQRTHRPSYEDRVCFV-----ATVRLA 258
Query: 270 TPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAAD 329
TP + + N F ++H L++ + D + ++GY E+ SGY + H D
Sbjct: 259 TPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGT-SGYDYYHVDD 317
Query: 330 MLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYK--NGRPDYIIVT 382
+ A+ H +++ G+ +R LTK +W W+Q++ + Y N RP++I+ T
Sbjct: 318 LENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCT 372
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 97.4 bits (241), Expect = 5e-20
Identities = 93/350 (26%), Positives = 147/350 (42%), Gaps = 55/350 (15%)
Query: 32 KSNPSKRHRDRLNTE-LDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
KS + R R TE L +LA LPF + V LDK S++RL++SYLR +
Sbjct: 16 KSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQ 75
Query: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
D C L+AL GFV+V+T + + Y S + +LG Q
Sbjct: 76 VGAGGEPLDAC----------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 119
Query: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
++I S+++ IH D+ E Q AL P Q T S + +E T
Sbjct: 120 LELIGHSIFDFIHPCDQEELQD----ALTPQQ-TLSRRKVEAPT---------------- 158
Query: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILP 260
ERCF R++ L + ++ + +N G ++ + GS P
Sbjct: 159 ------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEP 212
Query: 261 PQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGS 320
P L I + P LE F ++H LD CD + V GY+ +L S
Sbjct: 213 PLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCS 271
Query: 321 GYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLL 370
Y++IHA D ++S ++ G++ +R L ++ + W Q+ A ++
Sbjct: 272 AYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVV 321
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 97.4 bits (241), Expect = 5e-20
Identities = 93/350 (26%), Positives = 147/350 (42%), Gaps = 55/350 (15%)
Query: 32 KSNPSKRHRDRLNTE-LDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
KS + R R TE L +LA LPF + V LDK S++RL++SYLR +
Sbjct: 18 KSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQ 77
Query: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
D C L+AL GFV+V+T + + Y S + +LG Q
Sbjct: 78 VGAGGEPLDAC----------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 121
Query: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
++I S+++ IH D+ E Q AL P Q T S + +E T
Sbjct: 122 LELIGHSIFDFIHPCDQEELQD----ALTPQQ-TLSRRKVEAPT---------------- 160
Query: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILP 260
ERCF R++ L + ++ + +N G ++ + GS P
Sbjct: 161 ------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEP 214
Query: 261 PQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGS 320
P L I + P LE F ++H LD CD + V GY+ +L S
Sbjct: 215 PLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCS 273
Query: 321 GYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLL 370
Y++IHA D ++S ++ G++ +R L ++ + W Q+ A ++
Sbjct: 274 AYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVV 323
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 94.0 bits (232), Expect = 5e-19
Identities = 88/343 (25%), Positives = 157/343 (45%), Gaps = 54/343 (15%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S KR RD++N+ +D LASL+P + KLDKL+VLR++V +++
Sbjct: 35 SQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------- 81
Query: 93 ERNGGQDNCRAANFREGLNLQEGE---FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGF 148
G + AN++ L + E +L+A +GF+ VV D + + S ++ L +
Sbjct: 82 -LRGATNPYTEANYKPTF-LSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNY 139
Query: 149 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLP-QTVVCYNPDQ 207
Q+D+I QS+++ +H +D A+ + Q L+ S + I+ TGLP +T + P +
Sbjct: 140 SQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLIDAKTGLPVKTDITPGPSR 195
Query: 208 IPPENSPLMERCFICRLRC-----------------LLDNSSGFLAMNFQGKLKY----- 245
+ R F CR++C + F ++ G LK
Sbjct: 196 L----CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTK 251
Query: 246 --LHGQKKKGKDGSILPPQLALFAIATPLQP-PSILEIRTKNFIFRTKHKLDFTPIGCDA 302
L + +G L +A+ + + + P P EIR K+ + ++H +D + D
Sbjct: 252 MGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQ 311
Query: 303 KGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGE 345
+ +L Y EL S Y++ H D+ + AE H ++++T E
Sbjct: 312 RATAILAYLPQELLGT-SCYEYFHQDDIGHLAECHRQVLQTRE 353
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 94.0 bits (232), Expect = 5e-19
Identities = 88/343 (25%), Positives = 157/343 (45%), Gaps = 54/343 (15%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S KR RD++N+ +D LASL+P + KLDKL+VLR++V +++
Sbjct: 78 SQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------- 124
Query: 93 ERNGGQDNCRAANFREGLNLQEGE---FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGF 148
G + AN++ L + E +L+A +GF+ VV D + + S ++ L +
Sbjct: 125 -LRGATNPYTEANYKPTF-LSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNY 182
Query: 149 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLP-QTVVCYNPDQ 207
Q+D+I QS+++ +H +D A+ + Q L+ S + I+ TGLP +T + P +
Sbjct: 183 SQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLIDAKTGLPVKTDITPGPSR 238
Query: 208 IPPENSPLMERCFICRLRC-----------------LLDNSSGFLAMNFQGKLKY----- 245
+ R F CR++C + F ++ G LK
Sbjct: 239 L----CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTK 294
Query: 246 --LHGQKKKGKDGSILPPQLALFAIATPLQP-PSILEIRTKNFIFRTKHKLDFTPIGCDA 302
L + +G L +A+ + + + P P EIR K+ + ++H +D + D
Sbjct: 295 MGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQ 354
Query: 303 KGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGE 345
+ +L Y EL S Y++ H D+ + AE H ++++T E
Sbjct: 355 RATAILAYLPQELLGT-SCYEYFHQDDIGHLAECHRQVLQTRE 396
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 94.0 bits (232), Expect = 5e-19
Identities = 88/343 (25%), Positives = 157/343 (45%), Gaps = 54/343 (15%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S KR RD++N+ +D LASL+P + KLDKL+VLR++V +++
Sbjct: 78 SQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT------------- 124
Query: 93 ERNGGQDNCRAANFREGLNLQEGE---FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGF 148
G + AN++ L + E +L+A +GF+ VV D + + S ++ L +
Sbjct: 125 -LRGATNPYTEANYKPTF-LSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNY 182
Query: 149 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLP-QTVVCYNPDQ 207
Q+D+I QS+++ +H +D A+ + Q L+ S + I+ TGLP +T + P +
Sbjct: 183 SQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLIDAKTGLPVKTDITPGPSR 238
Query: 208 IPPENSPLMERCFICRLRC-----------------LLDNSSGFLAMNFQGKLKY----- 245
+ R F CR++C + F ++ G LK
Sbjct: 239 L----CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTK 294
Query: 246 --LHGQKKKGKDGSILPPQLALFAIATPLQP-PSILEIRTKNFIFRTKHKLDFTPIGCDA 302
L + +G L +A+ + + + P P EIR K+ + ++H +D + D
Sbjct: 295 MGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQ 354
Query: 303 KGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGE 345
+ +L Y EL S Y++ H D+ + AE H ++++T E
Sbjct: 355 RATAILAYLPQELLGT-SCYEYFHQDDIGHLAECHRQVLQTRE 396
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 86.3 bits (212), Expect = 1e-16
Identities = 86/359 (23%), Positives = 158/359 (44%), Gaps = 33/359 (9%)
Query: 32 KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSP 91
++ K+ RD+ N + L+S+LP K+DK +VL + +L+ + S+
Sbjct: 14 RNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV-----SAQ 65
Query: 92 TERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQS 151
TE Q + + + N + + +L+AL+GF++ VTTD + Y S +I LG S
Sbjct: 66 TEICDIQQDWKPSFLS---NEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPS 122
Query: 152 DVIHQSVYELIHTEDRAEFQRQL--HWALNPSQCTE---SGQGIEEATGLPQTVVCYNPD 206
DV+ Q++ + ++ +E + L H + S E S +E L +
Sbjct: 123 DVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLR-------G 175
Query: 207 QIPPENSPLMERC-FICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLAL 265
+ P+ P E F+ R +N F L + GK+ +A
Sbjct: 176 SLNPKEFPTYEYIKFVGNFRS-YNNVPSPSCNGFDNTLS-RPCRVPLGKEVCF----IAT 229
Query: 266 FAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFI 325
+ATP + + F ++H L++ + D + ++GY E+ SGY +
Sbjct: 230 VRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGT-SGYDYY 288
Query: 326 HAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYK--NGRPDYIIVT 382
H D+ A H +++ G+ +R LTK +W W+Q++ + Y N +P++I+ T
Sbjct: 289 HIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCT 347
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 85.9 bits (211), Expect = 1e-16
Identities = 93/393 (23%), Positives = 152/393 (38%), Gaps = 82/393 (20%)
Query: 36 SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERN 95
SK RD++N E+ L LLP + +L L ++ L+ Y R FF
Sbjct: 9 SKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFA----------- 57
Query: 96 GGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIH 155
GG L+ QE E ++ AL GF+LV T + + Y S ++ ++LG D++
Sbjct: 58 GGTPLAGPTGL---LSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVA 114
Query: 156 Q--SVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213
Q S+Y++I D ++QL LP + + D++
Sbjct: 115 QGDSIYDIIDPADHLTVRQQL--------------------TLPSAL---DTDRL----- 146
Query: 214 PLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQ 273
RC + S + KL + G+ G+ A PL+
Sbjct: 147 ----------FRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE 196
Query: 274 P-----------PSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGY 322
P P+ L + +F+++H D + I LG+ +EL + S Y
Sbjct: 197 PRPRPGPGPGPGPASLFLA----MFQSRHAKDLALLDISESVLIYLGFERSELLCK-SWY 251
Query: 323 QFIHAADMLYCAESHIRMIKTGESGMI----VFRLLTKNNRWTWVQSNARLLYKNGRPDY 378
+H D+ + + H R++ ESG I V RL K W W+ LLY G
Sbjct: 252 GLLHPEDLAHASAQHYRLL--AESGDIQAEMVVRLQAKTGGWAWIYC---LLYSEGPEGP 306
Query: 379 IIVTQRPLTDEEG---TEHLRKRNTKLPFMFTT 408
I P++D E + L +T+ ++ T
Sbjct: 307 ITANNYPISDMEAWSLRQQLNSEDTQAAYVLGT 339
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 78.6 bits (192), Expect = 2e-14
Identities = 68/262 (25%), Positives = 114/262 (43%), Gaps = 38/262 (14%)
Query: 119 LQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWAL 178
L+AL GFV+V+T + + Y S + +LG Q ++I S+++ IH D+ E Q AL
Sbjct: 34 LKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQD----AL 89
Query: 179 NPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDN-------- 230
P Q T S + +E T ERCF R++ L +
Sbjct: 90 TPQQ-TLSRRKVEAPT----------------------ERCFSLRMKSTLTSRGRTLNLK 126
Query: 231 SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILPPQLALFAIATPLQPPSILEIRTKNFIFR 288
++ + +N G ++ + GS PP L I + P LE F
Sbjct: 127 AATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFL 186
Query: 289 TKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGM 348
++H LD CD + V GY+ +L S Y++IHA D ++S ++ G++
Sbjct: 187 SRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCSAYEYIHALDSDAVSKSIHTLLSKGQAVT 245
Query: 349 IVFRLLTKNNRWTWVQSNARLL 370
+R L ++ + W Q+ A ++
Sbjct: 246 GQYRFLARSGGYLWTQTQATVV 267
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 73.9 bits (180), Expect = 6e-13
Identities = 84/370 (22%), Positives = 160/370 (43%), Gaps = 51/370 (13%)
Query: 3 SSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVIN 62
S+ I+ +S R + + VK S KR RD++N ++ L++++P +
Sbjct: 83 STRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMAR 142
Query: 63 KLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGE---FLL 119
KLDKL+VLR++V +LR+ G ++ +N+R LQ+ E +L
Sbjct: 143 KLDKLTVLRMAVQHLRS--------------LKGLTNSYVGSNYRPSF-LQDNELRHLIL 187
Query: 120 QALNGFVLVVTTD-ALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL-HWA 177
+ GF+ VV + + + S ++ L + Q+ + QS+++ +H +D A+ + QL +
Sbjct: 188 KTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFD 247
Query: 178 LNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLR-----------C 226
++P + + I+ TGL V N R F CR++ C
Sbjct: 248 ISPRE-----KLIDAKTGLQ---VHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGC 299
Query: 227 LLDNSS----GFLAMNFQGKLKY-------LHGQKKKGKDGSILPPQLALFAIATPLQPP 275
L ++ F ++ G L+ + ++ KD S +A+ + + P
Sbjct: 300 LPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQ 359
Query: 276 SILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAE 335
+ EI K F T+ ++ + D + +LGY EL S Y++ H D +
Sbjct: 360 NSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGT-SCYEYFHQDDHNNLTD 418
Query: 336 SHIRMIKTGE 345
H ++++ E
Sbjct: 419 KHKAVLQSKE 428
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 70.9 bits (172), Expect = 5e-12
Identities = 50/171 (29%), Positives = 85/171 (49%), Gaps = 20/171 (11%)
Query: 12 SRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFP-QDVIN---KLDKL 67
SRKR+ P P +G+ + KR R++ + ++ LA L+ D+ N K DK
Sbjct: 15 SRKRKLPCDT-----PGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKC 69
Query: 68 SVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQE----GEFLLQALN 123
++L+ +V +R +K + D +A G + + G LLQAL+
Sbjct: 70 AILKETVRQIRQ-------IKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALD 122
Query: 124 GFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
GF+ VV D + + S + YL ++Q D+++ SVY ++H EDR +F + L
Sbjct: 123 GFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL 173
Score = 30.0 bits (66), Expect = 9.4
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 3/80 (3%)
Query: 597 SDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMK---HMQVNGMFEN 653
S + +QQ +A+ Q+ +QQQQ Q+Q + QQQ Q ++ + +
Sbjct: 1235 SHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDG 1294
Query: 654 WNSNQFVPFNCPQQDPQQYN 673
+ +P PQQ P Q N
Sbjct: 1295 LLAGPTMPQAPPQQFPYQPN 1314
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 70.9 bits (172), Expect = 5e-12
Identities = 50/171 (29%), Positives = 85/171 (49%), Gaps = 20/171 (11%)
Query: 12 SRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFP-QDVIN---KLDKL 67
SRKR+ P P +G+ + KR R++ + ++ LA L+ D+ N K DK
Sbjct: 15 SRKRKLPCDT-----PGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKC 69
Query: 68 SVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQE----GEFLLQALN 123
++L+ +V +R +K + D +A G + + G LLQAL+
Sbjct: 70 AILKETVRQIRQ-------IKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALD 122
Query: 124 GFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
GF+ VV D + + S + YL ++Q D+++ SVY ++H EDR +F + L
Sbjct: 123 GFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL 173
Score = 30.0 bits (66), Expect = 9.4
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 3/80 (3%)
Query: 597 SDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMK---HMQVNGMFEN 653
S + +QQ +A+ Q+ +QQQQ Q+Q + QQQ Q ++ + +
Sbjct: 1231 SHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDG 1290
Query: 654 WNSNQFVPFNCPQQDPQQYN 673
+ +P PQQ P Q N
Sbjct: 1291 LLAGPTMPQAPPQQFPYQPN 1310
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/160 (28%), Positives = 82/160 (51%), Gaps = 16/160 (10%)
Query: 24 KPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKL----DKLSVLRLSVSYLRA 79
K P + + S+ KR R++ N L+ LA LL I+ L DK +L+ +V ++
Sbjct: 20 KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQL 79
Query: 80 KSFFDVALKSSPTERNGGQDNCRAANFR---EGLNLQE--GEFLLQALNGFVLVVTTDAL 134
+K E++ D+ + ++ +G+ +E G LL+AL+GF VV +
Sbjct: 80 -------MKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGR 132
Query: 135 VFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
+ + S + YLG+ Q ++++ SVY ++H D AEF + L
Sbjct: 133 IVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/160 (28%), Positives = 82/160 (51%), Gaps = 16/160 (10%)
Query: 24 KPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKL----DKLSVLRLSVSYLRA 79
K P + + S+ KR R++ N L+ LA LL I+ L DK +L+ +V ++
Sbjct: 20 KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQL 79
Query: 80 KSFFDVALKSSPTERNGGQDNCRAANFR---EGLNLQE--GEFLLQALNGFVLVVTTDAL 134
+K E++ D+ + ++ +G+ +E G LL+AL+GF VV +
Sbjct: 80 -------MKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGR 132
Query: 135 VFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
+ + S + YLG+ Q ++++ SVY ++H D AEF + L
Sbjct: 133 IVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/160 (28%), Positives = 82/160 (51%), Gaps = 16/160 (10%)
Query: 24 KPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKL----DKLSVLRLSVSYLRA 79
K P + + S+ KR R++ N L+ LA LL I+ L DK +L+ +V ++
Sbjct: 20 KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQL 79
Query: 80 KSFFDVALKSSPTERNGGQDNCRAANFR---EGLNLQE--GEFLLQALNGFVLVVTTDAL 134
+K E++ D+ + ++ +G+ +E G LL+AL+GF VV +
Sbjct: 80 -------MKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGR 132
Query: 135 VFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
+ + S + YLG+ Q ++++ SVY ++H D AEF + L
Sbjct: 133 IVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 67.8 bits (164), Expect = 4e-11
Identities = 73/295 (24%), Positives = 123/295 (41%), Gaps = 64/295 (21%)
Query: 1 MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFP-QD 59
M ++++ + A ++RK + P P K N KR+R++ N ++ LA L+ D
Sbjct: 4 MGENTSDPSRAETRKRKECPDQLGPSP----KRNTEKRNREQENKYIEELAELIFANFND 59
Query: 60 VIN---KLDKLSVLRLSVSYLR--------AKSFFDVALKSSPTERNGGQDNCRAANFRE 108
+ N K DK ++L+ +V +R A + D KS + G + A
Sbjct: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDAL---- 115
Query: 109 GLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRA 168
G +L+AL+GF VV + V + S + YL + Q +++++SVY ++H D
Sbjct: 116 ------GPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHT 169
Query: 169 EFQRQL---------HWALNPSQ-----------------CTESGQGIEEATGLPQTVVC 202
EF + L W+ P + E G +EA +T+ C
Sbjct: 170 EFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQC 229
Query: 203 Y---NPDQIPPENSPLMERCFIC-------RLRCLLDNSSGFLA-MNFQGKLKYL 246
+ P I E L + C IC + R +L +S F + QGK+ L
Sbjct: 230 FAVSQPKSIKEEGEDL-QSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSL 283
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 65.1 bits (157), Expect = 3e-10
Identities = 90/389 (23%), Positives = 153/389 (39%), Gaps = 62/389 (15%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S +R R+++ + L+ ++P + K DKL++LR++VS+ +KS
Sbjct: 69 SEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSH----------MKSMRG 118
Query: 93 ERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTD-ALVFYASSTIQDYLGFQQS 151
N D +F L+ +L+A +GF+ VV + V Y S ++ L QS
Sbjct: 119 TGNKSTDGAYKPSFLTEQELK--HLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQS 176
Query: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211
+ ++YE +H +D + + QL CT L V Q
Sbjct: 177 EWFGSTLYEQVHPDDVEKLREQL--------CTSENSMTGRILDLKTGTVKKEGQQSSMR 228
Query: 212 NSPLMERCFICRLRC---LLDNSSGFLAMNFQGKLKYLHGQKKKGK-------------- 254
R FICR+RC LD+ + + + G K+G+
Sbjct: 229 MCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKA 288
Query: 255 ---DGSILPPQLA---------LFAIATPLQPPSILEIRTKNFI-----FRTKHKLDFTP 297
G +P + A L AI LQ S N + F ++H D
Sbjct: 289 WPPAGMTIPEEDADVGQGSKYCLVAIGR-LQVTSSPVCMDMNGMSVPTEFLSRHNSDGII 347
Query: 298 IGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIK-TGESGMIVFRLLTK 356
D + V+GY +L + +F H D + ES +++K G+ +++R TK
Sbjct: 348 TFVDPRCISVIGYQPQDLLGKDI-LEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTK 406
Query: 357 NNRWTWVQSNARLLYKNGRPD---YIIVT 382
N W +++++ ++N D YII T
Sbjct: 407 NREWMLIRTSS-FTFQNPYSDEIEYIICT 434
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 63.2 bits (152), Expect = 1e-09
Identities = 86/393 (21%), Positives = 159/393 (40%), Gaps = 70/393 (17%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S +R R+++ + L+ ++P + K DKL++LR++VS+ +KS
Sbjct: 80 SEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH----------MKSLRG 129
Query: 93 ERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTD-ALVFYASSTIQDYLGFQQS 151
N D +F L+ +L+A +GF+ +V+ + V Y S ++ L QS
Sbjct: 130 TGNTSTDGSYKPSFLTDQELK--HLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQS 187
Query: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211
+ ++Y+ +H +D + + Q L+ S+ +G+ ++ TG V Q
Sbjct: 188 EWFGSTLYDQVHPDDVDKLREQ----LSTSENALTGRILDLKTG----TVKKEGQQSSMR 239
Query: 212 NSPLMERCFICRLRC--------------------------LLDNSSGFLAMNFQGKLK- 244
R FICR+RC + D F+ ++ G +K
Sbjct: 240 MCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKA 299
Query: 245 ------YLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFI-----FRTKHKL 293
L + GS + L AI LQ S + + F ++H +
Sbjct: 300 WPPAGVSLPDDDPEAGQGS----KFCLVAIGR-LQVTSSPNCTDMSNVCQPTEFISRHNI 354
Query: 294 DFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIK-TGESGMIVFR 352
+ D + +GY EL + +F H D +S +++K G+ ++FR
Sbjct: 355 EGIFTFVDHRCVATVGYQPQELLGKNI-VEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFR 413
Query: 353 LLTKNNRWTWVQSNARLLYKNGRPD---YIIVT 382
+KN W W+++++ ++N D YII T
Sbjct: 414 FRSKNQEWLWMRTSS-FTFQNPYSDEIEYIICT 445
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 63.2 bits (152), Expect = 1e-09
Identities = 86/393 (21%), Positives = 159/393 (40%), Gaps = 70/393 (17%)
Query: 33 SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92
S +R R+++ + L+ ++P + K DKL++LR++VS+ +KS
Sbjct: 95 SEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH----------MKSLRG 144
Query: 93 ERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTD-ALVFYASSTIQDYLGFQQS 151
N D +F L+ +L+A +GF+ +V+ + V Y S ++ L QS
Sbjct: 145 TGNTSTDGSYKPSFLTDQELK--HLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQS 202
Query: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211
+ ++Y+ +H +D + + Q L+ S+ +G+ ++ TG V Q
Sbjct: 203 EWFGSTLYDQVHPDDVDKLREQ----LSTSENALTGRILDLKTG----TVKKEGQQSSMR 254
Query: 212 NSPLMERCFICRLRC--------------------------LLDNSSGFLAMNFQGKLK- 244
R FICR+RC + D F+ ++ G +K
Sbjct: 255 MCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKA 314
Query: 245 ------YLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFI-----FRTKHKL 293
L + GS + L AI LQ S + + F ++H +
Sbjct: 315 WPPAGVSLPDDDPEAGQGS----KFCLVAIGR-LQVTSSPNCTDMSNVCQPTEFISRHNI 369
Query: 294 DFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIK-TGESGMIVFR 352
+ D + +GY EL + +F H D +S +++K G+ ++FR
Sbjct: 370 EGIFTFVDHRCVATVGYQPQELLGKNI-VEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFR 428
Query: 353 LLTKNNRWTWVQSNARLLYKNGRPD---YIIVT 382
+KN W W+++++ ++N D YII T
Sbjct: 429 FRSKNQEWLWMRTSS-FTFQNPYSDEIEYIICT 460
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,052,276
Number of Sequences: 37866
Number of extensions: 1724351
Number of successful extensions: 6010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 5214
Number of HSP's gapped (non-prelim): 341
length of query: 848
length of database: 18,247,518
effective HSP length: 111
effective length of query: 737
effective length of database: 14,044,392
effective search space: 10350716904
effective search space used: 10350716904
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.