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Search of human proteins with 126091152
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126091152 cubilin [Homo sapiens]
(3623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126091152 cubilin [Homo sapiens] 7661 0.0
gi|239755296 PREDICTED: similar to hCG1644292 [Homo sapiens] 459 e-128
gi|239749791 PREDICTED: similar to hCG1644292 [Homo sapiens] 457 e-128
gi|22547221 tolloid-like 1 [Homo sapiens] 320 2e-86
gi|6912724 tolloid-like 2 [Homo sapiens] 317 1e-85
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 311 6e-84
gi|4557679 jagged 1 precursor [Homo sapiens] 216 3e-55
gi|148833508 notch1 preproprotein [Homo sapiens] 210 2e-53
gi|134244285 Notch homolog 3 [Homo sapiens] 209 4e-53
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 208 9e-53
gi|24041035 notch 2 preproprotein [Homo sapiens] 207 2e-52
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 205 6e-52
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 204 1e-51
gi|55770876 notch4 preproprotein [Homo sapiens] 202 6e-51
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 201 8e-51
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 198 7e-50
gi|112420992 crumbs homolog 2 [Homo sapiens] 181 2e-44
gi|110347437 latent transforming growth factor beta binding prot... 174 2e-42
gi|110347412 latent transforming growth factor beta binding prot... 174 2e-42
gi|110347431 latent transforming growth factor beta binding prot... 174 2e-42
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 172 5e-42
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 168 8e-41
gi|24430141 fibrillin 1 precursor [Homo sapiens] 167 1e-40
gi|110735443 delta-like 1 [Homo sapiens] 155 7e-37
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 149 4e-35
gi|56237021 fibrillin 3 precursor [Homo sapiens] 149 6e-35
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 148 8e-35
gi|66346695 fibrillin 2 precursor [Homo sapiens] 148 1e-34
gi|4557733 latent transforming growth factor beta binding protei... 148 1e-34
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 145 5e-34
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 7661 bits (19878), Expect = 0.0
Identities = 3623/3623 (100%), Positives = 3623/3623 (100%)
Query: 1 MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQN 60
MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQN
Sbjct: 1 MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQN 60
Query: 61 IEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDL 120
IEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDL
Sbjct: 61 IEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDL 120
Query: 121 ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGT 180
ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGT
Sbjct: 121 ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGT 180
Query: 181 PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE 240
PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE
Sbjct: 181 PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE 240
Query: 241 PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG 300
PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG
Sbjct: 241 PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG 300
Query: 301 YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC 360
YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC
Sbjct: 301 YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC 360
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC 420
HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC
Sbjct: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC 420
Query: 421 DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG 480
DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG
Sbjct: 421 DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG 480
Query: 481 INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS 540
INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS
Sbjct: 481 INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS 540
Query: 541 SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGS 600
SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGS
Sbjct: 541 SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGS 600
Query: 601 IKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPL 660
IKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPL
Sbjct: 601 IKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPL 660
Query: 661 LGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELF 720
LGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELF
Sbjct: 661 LGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELF 720
Query: 721 LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCG 780
LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCG
Sbjct: 721 LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCG 780
Query: 781 NGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER 840
NGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER
Sbjct: 781 NGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER 840
Query: 841 TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFIT 900
TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFIT
Sbjct: 841 TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFIT 900
Query: 901 SVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTW 960
SVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTW
Sbjct: 901 SVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTW 960
Query: 961 HILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSL 1020
HILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSL
Sbjct: 961 HILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSL 1020
Query: 1021 MLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITV 1080
MLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITV
Sbjct: 1021 MLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITV 1080
Query: 1081 RTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLW 1140
RTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLW
Sbjct: 1081 RTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLW 1140
Query: 1141 LKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHG 1200
LKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHG
Sbjct: 1141 LKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHG 1200
Query: 1201 SAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR 1260
SAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR
Sbjct: 1201 SAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR 1260
Query: 1261 TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY 1320
TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY
Sbjct: 1261 TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY 1320
Query: 1321 TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK 1380
TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK
Sbjct: 1321 TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK 1380
Query: 1381 GFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY 1440
GFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY
Sbjct: 1381 GFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY 1440
Query: 1441 HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN 1500
HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN
Sbjct: 1441 HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN 1500
Query: 1501 ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ
Sbjct: 1501 ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
Query: 1561 DSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQAC 1620
DSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQAC
Sbjct: 1561 DSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQAC 1620
Query: 1621 GGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV 1680
GGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV
Sbjct: 1621 GGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV 1680
Query: 1681 EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGG 1740
EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGG
Sbjct: 1681 EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGG 1740
Query: 1741 TFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE 1800
TFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE
Sbjct: 1741 TFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE 1800
Query: 1801 GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTH 1860
GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTH
Sbjct: 1801 GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTH 1860
Query: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
Query: 1921 RLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGG 1980
RLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGG
Sbjct: 1921 RLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGG 1980
Query: 1981 FLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIR 2040
FLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIR
Sbjct: 1981 FLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIR 2040
Query: 2041 DGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR 2100
DGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR
Sbjct: 2041 DGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR 2100
Query: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160
GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD
Sbjct: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160
Query: 2161 ICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGN 2220
ICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGN
Sbjct: 2161 ICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGN 2220
Query: 2221 VYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYL 2280
VYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYL
Sbjct: 2221 VYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYL 2280
Query: 2281 ELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRV 2340
ELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRV
Sbjct: 2281 ELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRV 2340
Query: 2341 PGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN 2400
PGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN
Sbjct: 2341 PGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN 2400
Query: 2401 HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSI 2460
HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSI
Sbjct: 2401 HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSI 2460
Query: 2461 GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS 2520
GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS
Sbjct: 2461 GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS 2520
Query: 2521 PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEG 2580
PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEG
Sbjct: 2521 PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEG 2580
Query: 2581 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA 2640
NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA
Sbjct: 2581 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA 2640
Query: 2641 DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVI 2700
DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVI
Sbjct: 2641 DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVI 2700
Query: 2701 TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPII 2760
TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPII
Sbjct: 2701 TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPII 2760
Query: 2761 GQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPH 2820
GQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPH
Sbjct: 2761 GQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPH 2820
Query: 2821 WPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLA 2880
WPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLA
Sbjct: 2821 WPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLA 2880
Query: 2881 TGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY 2940
TGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY
Sbjct: 2881 TGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY 2940
Query: 2941 DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCG 3000
DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCG
Sbjct: 2941 DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCG 3000
Query: 3001 DEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN 3060
DEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN
Sbjct: 3001 DEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN 3060
Query: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN
Sbjct: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
Query: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYD 3180
VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYD
Sbjct: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYD 3180
Query: 3181 KNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGST 3240
KNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGST
Sbjct: 3181 KNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGST 3240
Query: 3241 VPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPD 3300
VPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPD
Sbjct: 3241 VPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPD 3300
Query: 3301 VPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA 3360
VPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA
Sbjct: 3301 VPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA 3360
Query: 3361 VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKD 3420
VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKD
Sbjct: 3361 VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKD 3420
Query: 3421 CTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFS 3480
CTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFS
Sbjct: 3421 CTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFS 3480
Query: 3481 QNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWV 3540
QNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWV
Sbjct: 3481 QNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWV 3540
Query: 3541 LVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSN 3600
LVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSN
Sbjct: 3541 LVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSN 3600
Query: 3601 QVFIKFHADYARRPSAFRLTWDS 3623
QVFIKFHADYARRPSAFRLTWDS
Sbjct: 3601 QVFIKFHADYARRPSAFRLTWDS 3623
>gi|239755296 PREDICTED: similar to hCG1644292 [Homo sapiens]
Length = 671
Score = 459 bits (1182), Expect = e-128
Identities = 242/333 (72%), Positives = 249/333 (74%), Gaps = 69/333 (20%)
Query: 2312 MYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLS 2371
MYLRFRSDNSP H+GFK GLS
Sbjct: 1 MYLRFRSDNSPNHMGFK----------------------------------------GLS 20
Query: 2372 GHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFV 2431
HYLT SFEDFNLQNSSGCEKDFVEIWD HTSGNILGRYC NTIPDS DTSSNTAVVR V
Sbjct: 21 RHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVR-V 79
Query: 2432 TDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRIT 2491
GS QGS GT TSPNYPN NPHGRI EWRITAPEGR+IT
Sbjct: 80 WWGS---------------------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 2492 LMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDG 2551
L F+NLRLATH SCN+EHVIVFNGIRSNSPQLEKLCSSVNVS+EIKSSGNTMKVIFFTDG
Sbjct: 119 LTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 2552 SRPYGGFTASYTSSEDA-------VCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 2604
SRPYGGFTAS+TSSEDA +CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 2605 NPNQGNSSISIHFEDFYLESHQDCQFDVLEFRV 2637
NPNQGNSSI IHFEDFYLESHQDCQFDVLEFRV
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRV 271
Score = 90.9 bits (224), Expect = 2e-17
Identities = 72/279 (25%), Positives = 120/279 (43%), Gaps = 39/279 (13%)
Query: 1301 SENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYD---GPRQMGRYCGVDLPP 1357
S+N + + + + + +F F+L++ C D++E++D +GRYC +P
Sbjct: 7 SDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPD 66
Query: 1358 PGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKEC 1417
T+S+ V + W+ G + G+ G+ +SP +PN P +
Sbjct: 67 STDTSSNTAVVRV---------------WW----GSQ--GSAGTSTSPNYPNLNPHGRIY 105
Query: 1418 IWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQV 1477
W I G I LT + + H CN + + ++ G +SP++ +LC+ S ++
Sbjct: 106 EWRITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCS--SVNVSSEI 163
Query: 1478 SSTGNELAIRFKTDLSINGRGFNASW----QAVTGGC-----GGIFQAPSGEIHSPNYPS 1528
S+GN + + F TD S GF AS A GC G + P G SP Y
Sbjct: 164 KSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDG 223
Query: 1529 --PYRSNTDCSWVIRVDR--NHRVLLNFTDFDLEPQDSC 1563
Y N +C W + N + ++F DF LE C
Sbjct: 224 VRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262
Score = 89.0 bits (219), Expect = 8e-17
Identities = 76/271 (28%), Positives = 117/271 (43%), Gaps = 40/271 (14%)
Query: 968 HLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS-LGRYCGKSIPPSLTSSGNSLMLVFVT 1026
H + FE F+L+ C D++E++D + + LGRYC +IP S +S N+ ++
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVWW 81
Query: 1027 DSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLI 1086
S GT TSPN+PN P+ +RIT G+ I
Sbjct: 82 GSQ------------------------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQI 117
Query: 1087 AVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGS-NLPPTIISHSNKLWLKFKS 1145
+ F+N L + + ++ + + +G SP L S N+ I S N + + F +
Sbjct: 118 TLTFSNLRLATHL-SCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176
Query: 1146 DQIDTRSGFSAYWDGSSTG--------CGGNL-TTSSGTFISPNYP--MPYYHSSECYWW 1194
D GF+A S CGG+L T G F SP Y Y + C W
Sbjct: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT 236
Query: 1195 LKSSH--GSAFELEFKDFHLEHHPNCTLDYL 1223
L + + S+ + F+DF+LE H +C D L
Sbjct: 237 LSNPNQGNSSIYIHFEDFYLESHQDCQFDVL 267
Score = 89.0 bits (219), Expect = 8e-17
Identities = 76/267 (28%), Positives = 116/267 (43%), Gaps = 35/267 (13%)
Query: 749 NFTHVELQCQSDSSQNYIEVRDGET---LLGKVCGNGTISHIKSITNSVWIRFKIDASVE 805
+F LQ S ++++E+ D T +LG+ C N I S +
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN-----------------TIPDSTD 69
Query: 806 KASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGS 865
+S AV +V G + + G SP +PN+ P R W I P+ + I L F+ + +
Sbjct: 70 TSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAT 128
Query: 866 SAHCETDYVEIGSSSILGSPENKKYCGT-DIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
C +++V + + SP+ +K C + ++ S I S N + V F S GF A
Sbjct: 129 HLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTAS 188
Query: 925 F-SAED--------LACGEILTESTGTIQSPGHPNV--YPHGINCTWHIL--VQPNHLIH 971
S+ED L G + G SPG+ V Y +NC W + Q N I+
Sbjct: 189 HTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY 248
Query: 972 LMFETFHLEFHYNCTNDYLEVYDTDSE 998
+ FE F+LE H +C D LE SE
Sbjct: 249 IHFEDFYLESHQDCQFDVLEFRVVASE 275
Score = 84.3 bits (207), Expect = 2e-15
Identities = 63/269 (23%), Positives = 115/269 (42%), Gaps = 32/269 (11%)
Query: 1779 SFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSG 1838
SF F L++S C +DFVEI + + +G+++GRYC N+ P
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIP-------------------DS 67
Query: 1839 SGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMD 1898
+ T ++++ G+ G SP +P PH Y+W + + +
Sbjct: 68 TDTSSNTAVVRVWWGSQ--GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125
Query: 1899 IEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTES--FSSTGNSLTFHFYSDSSISGKGF 1956
+ +C + + +++G ++ + C + S S+GN++ F++D S GF
Sbjct: 126 LATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGF 185
Query: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPD--SYSNRVDCTWLIQAP- 2013
+ + D V CGG L F SPG+ +YS ++C W + P
Sbjct: 186 TASHTSSEDADKV---GCCKLCGGSLPNTPEGNFT-SPGYDGVRNYSRNLNCEWTLSNPN 241
Query: 2014 --DSTVELNILSLDIESHRTCAYDSLVIR 2040
+S++ ++ +ESH+ C +D L R
Sbjct: 242 QGNSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 82.0 bits (201), Expect = 1e-14
Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 35/267 (13%)
Query: 515 TFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLR 574
+F F L++ C +F++++D +S LGR+C +++P +S N ++
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNI-LGRYCANTIPDSTDTSSNTAVVRVW----- 80
Query: 575 NGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGT 634
W +Q G G+ SP YP P GR W + +T TF
Sbjct: 81 --------WGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123
Query: 635 LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSV-PPLQTTGPFARIHFHSDSQISDQ 693
L L H CN +++ + +G P L K C++ +V ++++G ++ F +D
Sbjct: 124 LRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183
Query: 694 GFHITYLTSPSDLR------CGGNYTD-PEGELFLPELSGPFTHTR--QCVYMMKQPQ-- 742
GF ++ +S + CGG+ + PEG P G ++R C + + P
Sbjct: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243
Query: 743 GEQIQINFTHVELQCQSDSSQNYIEVR 769
I I+F L+ D + +E R
Sbjct: 244 NSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 80.9 bits (198), Expect = 2e-14
Identities = 71/249 (28%), Positives = 109/249 (43%), Gaps = 39/249 (15%)
Query: 2604 SNPNQ-GNSSISIH-----FEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLP 2657
++PN G +S H FEDF L++ C+ D +E G ++ R C T+P
Sbjct: 9 NSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN---TIP 65
Query: 2658 LVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSS 2717
S +N V + + ++ G +G TSPNYPN
Sbjct: 66 DSTDTS-------SNTAVVRVWWGSQ-----------GSAGTSTSPNYPNLNPHGRIYEW 107
Query: 2718 LLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRT-IQSGS 2776
+ AP+G ITLTFS+ + H +C + V V NG SP + + C + N + I+S
Sbjct: 108 RITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSG 167
Query: 2777 NQLVVTFNSDHSLQGGGFYATW----NTQTLGC-----GGIFHSDNGTIRSPHWP--QNF 2825
N + V F +D S GGF A+ + +GC G + ++ G SP + +N+
Sbjct: 168 NTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNY 227
Query: 2826 PENSRCSWT 2834
N C WT
Sbjct: 228 SRNLNCEWT 236
Score = 80.9 bits (198), Expect = 2e-14
Identities = 69/258 (26%), Positives = 106/258 (41%), Gaps = 45/258 (17%)
Query: 857 NFTVFEIGSSAHCETDYVEIG----SSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVK 912
+F F + +S+ CE D+VEI S +ILG +YC IP + N V
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILG-----RYCANTIPDSTDTSSNTAVVRVWW 81
Query: 913 SSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHL 972
S S GT SP +PN+ PHG W I I L
Sbjct: 82 GSQG----------------------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITL 119
Query: 973 MFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGK-SIPPSLTSSGNSLMLVFVTDSD 1029
F L H +C ++++ V++ + L + C ++ + SSGN++ ++F TD
Sbjct: 120 TFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGS 179
Query: 1030 LAYEGFLINYEAISAA--TACLQDYTDDL-----GTFTSPNFP--NNYPNNWECIYRIT- 1079
Y GF ++ + A C + L G FTSP + NY N C + ++
Sbjct: 180 RPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSN 239
Query: 1080 -VRTGQLIAVHFTNFSLE 1096
+ I +HF +F LE
Sbjct: 240 PNQGNSSIYIHFEDFYLE 257
Score = 79.0 bits (193), Expect = 8e-14
Identities = 67/264 (25%), Positives = 114/264 (43%), Gaps = 43/264 (16%)
Query: 1207 FKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQ 1266
F+DF+L++ C D++ ++D +S + +L + C + P +S ++ +++ G Q
Sbjct: 28 FEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWW--GSQ 84
Query: 1267 GRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD 1326
G G S YPN + W I A G + TF
Sbjct: 85 GSA-------------------GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125
Query: 1327 LEHHINCSTDYLELYDGPR----QMGRYCG-VDLPPPGSTTSSKLQVLLLTDGVGRREKG 1381
L H++C+++++ +++G R Q+ + C V++ ++ + ++V+ TDG R G
Sbjct: 126 LATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG-SRPYGG 184
Query: 1382 FQMQWFVYG----------CGGELSGAT-GSFSSPGFPN--RYPPNKECIWYIRT--DPG 1426
F CGG L G+F+SPG+ Y N C W +
Sbjct: 185 FTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGN 244
Query: 1427 SSIQLTIHDFDVEYHSRCNFDVLE 1450
SSI + DF +E H C FDVLE
Sbjct: 245 SSIYIHFEDFYLESHQDCQFDVLE 268
Score = 79.0 bits (193), Expect = 8e-14
Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 13/187 (6%)
Query: 3044 SSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGAN 3103
S+G TSP Y + P+ + IT + + I L FS+ + SC+ +++ +++G
Sbjct: 86 SAGTSTSPNYPNLN-PHGRIYEWRITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIR 144
Query: 3104 TSDPLLGKFCGSKR-PPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQT-----LGPQQGC 3157
++ P L K C S +KSS N+M ++F TD + G+ S + +G + C
Sbjct: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204
Query: 3158 GGYLTGS-NNTFASPDSDSNGMYDKNLNCVWIIIAP--VNKVIHLTFNTFALEAASTRQR 3214
GG L + F SP D Y +NLNC W + P N I++ F F LE + Q
Sbjct: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLE---SHQD 261
Query: 3215 CLYDYVK 3221
C +D ++
Sbjct: 262 CQFDVLE 268
Score = 77.8 bits (190), Expect = 2e-13
Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 49/274 (17%)
Query: 1658 NHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFV 1717
+++T SF F L+ S+ C +DFVEI D H + GRYC +P + S+ +R
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRVW 80
Query: 1718 SDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQ 1777
S SAG SP YP++ P W I + G ++
Sbjct: 81 WGSQGSAG----------------------TSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 1778 LSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV---GHTLWVRFI 1833
L+F + +L C+ + V + G + + + C + +N SS + G+T+ V F
Sbjct: 119 LTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSS---VNVSSEIKSSGNTMKVIFF 175
Query: 1834 SDGSGSGTGFQATF-----------MKIFGNDNIVGTHGKVASPFWP--ENYPHNSNYQW 1880
+DGS GF A+ K+ G G SP + NY N N +W
Sbjct: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235
Query: 1881 TVN----VNASHVVHGRILEMDIEEIQNCYYDKL 1910
T++ N+S +H + +E Q+C +D L
Sbjct: 236 TLSNPNQGNSSIYIH--FEDFYLESHQDCQFDVL 267
Score = 77.8 bits (190), Expect = 2e-13
Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 39/305 (12%)
Query: 1090 FTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQID 1149
F +F+L+ + G DF+EI D + +LG + + +P + + SN ++
Sbjct: 28 FEDFNLQNSSG-CEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRV------ 79
Query: 1150 TRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKD 1209
W GS S+GT SPNYP H W + + G L F +
Sbjct: 80 --------WWGSQG--------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123
Query: 1210 FHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGD-EKPPLIRSSGDSMFIKLRTDEGQQGR 1268
L H +C +++ V++G SNS L +LC I+SSG++M + TD +
Sbjct: 124 LRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183
Query: 1269 GFKAEYRQT--------CE--NVVIVNQTYGILESIGYP--NPYSENQHCNWTI-RATTG 1315
GF A + + C+ + N G S GY YS N +C WT+ G
Sbjct: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243
Query: 1316 NTVNYT-FLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDG 1374
N+ Y F F LE H +C D LE + + + + L+ L DG
Sbjct: 244 NSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLFADG 303
Query: 1375 VGRRE 1379
G RE
Sbjct: 304 TGLRE 308
Score = 76.6 bits (187), Expect = 4e-13
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 20/186 (10%)
Query: 2228 SAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVD 2287
SAG TSPN+P+ P W + AP +I L F + + +C S ++ + +G+
Sbjct: 86 SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN-LRLATHLSCNSEHVIVFNGIR 144
Query: 2288 SDAPILSKFCGTSLPSSQ-WSSGEVMYLRFRSDNSPTHVGFKAKYSIAQ----------C 2336
S++P L K C + SS+ SSG M + F +D S + GF A ++ ++ C
Sbjct: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204
Query: 2337 GGRVPG-QSGVVESIGHPTL-PYRDNLFCEWHL----QGLSGHYLTISFEDFNLQNSSGC 2390
GG +P G S G+ + Y NL CEW L QG S Y I FEDF L++ C
Sbjct: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY--IHFEDFYLESHQDC 262
Query: 2391 EKDFVE 2396
+ D +E
Sbjct: 263 QFDVLE 268
Score = 74.7 bits (182), Expect = 2e-12
Identities = 53/175 (30%), Positives = 81/175 (46%), Gaps = 14/175 (8%)
Query: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
G SP +P+ + + +TAP+ I+L F +L + + C ++ + V NG SNS
Sbjct: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIRSNS 147
Query: 3464 PLLGKYCGTL-LPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG--------CGGT 3514
P L K C ++ + + + S N + + F +D G+ TSS CGG+
Sbjct: 148 PQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGS 207
Query: 3515 LYG-DRGSFTSPGYPG--TYPNNTYCEWVLVAP--AGRLVTINFYFISIDDPGDC 3564
L G+FTSPGY G Y N CEW L P + I+F ++ DC
Sbjct: 208 LPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262
Score = 73.9 bits (180), Expect = 3e-12
Identities = 45/187 (24%), Positives = 80/187 (42%), Gaps = 23/187 (12%)
Query: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490
H ++ F ++NS C DF+E+ + S + +LG+YC +P+ + +N +R
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78
Query: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVT 3550
+W S G G+ TSP YP P+ EW + AP GR +T
Sbjct: 79 ------------VWWGSQ--------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 3551 INFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADY 3610
+ F + + C ++ +++G ++SP C + +S N + + F D
Sbjct: 119 LTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 3611 ARRPSAF 3617
+R F
Sbjct: 179 SRPYGGF 185
Score = 72.8 bits (177), Expect = 6e-12
Identities = 65/270 (24%), Positives = 106/270 (39%), Gaps = 48/270 (17%)
Query: 1432 TIHDFDVEYHSRCNFDVLEIYGGPDFHSPR--IAQLCTQRSPENPMQVSSTGNELAIRFK 1489
+ DF+++ S C D +EI+ D+H+ + + C P++
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIW---DYHTSGNILGRYCANTIPDS---------------- 67
Query: 1490 TDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVL 1549
TD S N W + Q +G SPNYP+ W I ++
Sbjct: 68 TDTSSNTAVVRVWWGS---------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 1550 LNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGP 1605
L F++ L SC ++ ++G+ S +L + C +++ I SSGN++ + F +
Sbjct: 119 LTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 1606 SRQNRGFRAQFRQA-----------CGGHILTSSFDTVSSPRFPA--NYPNNQNCSWIIQ 1652
SR GF A + CGG + + +SP + NY N NC W +
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 1653 AQPPLN-HITLSFTHFELERSTTCARDFVE 1681
N I + F F LE C D +E
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268
Score = 66.6 bits (161), Expect = 4e-10
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 16/165 (9%)
Query: 502 WVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS-SLPHELLSS 560
W I G+ + +TF+ RL + +C E + V++G S++ QL + C S ++ E+ SS
Sbjct: 107 WRITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSS 166
Query: 561 DNALYFHLYSEHLRNGRGFTVRWETQQPE--------CGGILTG-PYGSIKSPGYPG--N 609
N + +++ R GFT + + CGG L P G+ SPGY G N
Sbjct: 167 GNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRN 226
Query: 610 YPPGRDCVWIVVTSP---DLLVTFTFGTLSLEHHDDCNKDYLEIR 651
Y +C W +++P + + F LE H DC D LE R
Sbjct: 227 YSRNLNCEW-TLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 63.2 bits (152), Expect = 5e-09
Identities = 73/292 (25%), Positives = 120/292 (41%), Gaps = 48/292 (16%)
Query: 3080 FSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQT 3139
F DF++ S+ C D++ I+D +TS +LG++C + P + +S+N+ ++
Sbjct: 28 FEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPDSTDTSSNTAVV--------- 77
Query: 3140 AKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHL 3199
+ W S QG G T N +P +Y+ W I AP + I L
Sbjct: 78 -RVWWGS--------QGSAGTSTSPNYPNLNP---HGRIYE------WRITAPEGRQITL 119
Query: 3200 TFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGS-TVPAPFISSGNFLTVQFIS 3258
TF+ L +T C ++V +++G N+ C S V + SSGN + V F +
Sbjct: 120 TFSNLRL---ATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176
Query: 3259 DLTLEREGFNATYTIMD--------MPCGGTYNATWTPQNISSPNSSDPDVPFS---ICT 3307
D + GF A++T + CGG+ T N +SP D +S C
Sbjct: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT-PEGNFTSP-GYDGVRNYSRNLNCE 234
Query: 3308 WVIDSPPHQQVKITVWALQL---TSQDCTQNYLQLQDSPQGHGNSRFQFCGR 3356
W + +P I + + QDC + L+ + H F R
Sbjct: 235 WTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISR 286
Score = 62.4 bits (150), Expect = 8e-09
Identities = 66/264 (25%), Positives = 107/264 (40%), Gaps = 46/264 (17%)
Query: 2725 HTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFN 2784
H +T +F DF+++ + C D V + + + + I+G+YC N+ P + + SN VV
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78
Query: 2785 SDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLE 2844
W +Q GT SP++P P W + + +
Sbjct: 79 -----------VWWGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 2845 ISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPS-NTFTAVFQ 2903
++F N L + C + V V+ G + L C +V I S NT +F
Sbjct: 119 LTFSN--LRLATHLSCNSEHVIVFNGIRS-NSPQLEKLCSSVNVSSEIKSSGNTMKVIFF 175
Query: 2904 SQ-EAPAQGFSASFVSR-----------CGSNFTG-PSGYIISPNYP--KQYDNNMNCTY 2948
+ P GF+AS S CG + P G SP Y + Y N+NC +
Sbjct: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235
Query: 2949 VIEANP---LSVVLLTFVSFHLEA 2969
+ +NP S + + F F+LE+
Sbjct: 236 TL-SNPNQGNSSIYIHFEDFYLES 258
Score = 62.0 bits (149), Expect = 1e-08
Identities = 48/161 (29%), Positives = 73/161 (45%), Gaps = 18/161 (11%)
Query: 1993 SPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLA 2051
SP +P+ + W I AP+ + L +L + +H +C + +++ +G + + QL
Sbjct: 92 SPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLE 151
Query: 2052 VLCGR-EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKS-----------CGGYL-HA 2098
LC + I+S+G M + F +D S GF AS S CGG L +
Sbjct: 152 KLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT 211
Query: 2099 DRGIITSPKYP--ETYPSNLNCSWHVL--VQSGLTIAVHFE 2135
G TSP Y Y NLNC W + Q +I +HFE
Sbjct: 212 PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFE 252
Score = 59.7 bits (143), Expect = 5e-08
Identities = 67/270 (24%), Positives = 107/270 (39%), Gaps = 47/270 (17%)
Query: 628 VTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSD 687
+T +F +L++ C KD++EI D + +LG++C T+ A +
Sbjct: 24 LTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWWG 82
Query: 688 SQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQ 747
SQ S G T P P L+ H R + + P+G QI
Sbjct: 83 SQGS-----------------AGTSTSPN----YPNLN---PHGRIYEWRITAPEGRQIT 118
Query: 748 INFTHV----ELQCQSDSSQNYIEVRDGETLLGKVCGNGTI-SHIKSITNSVWIRFKIDA 802
+ F+++ L C S+ + +R L K+C + + S IKS N++ + F D
Sbjct: 119 LTFSNLRLATHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 803 SVEKASFRAVYQVA-----------CGDEL--TGEGVIRSPFFPNV--YPGERTCRWTIH 847
S F A + + CG L T EG SP + V Y C WT+
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 848 QPQ--SQVILLNFTVFEIGSSAHCETDYVE 875
P + I ++F F + S C+ D +E
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268
Score = 54.7 bits (130), Expect = 2e-06
Identities = 56/196 (28%), Positives = 82/196 (41%), Gaps = 26/196 (13%)
Query: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160
G TSP YP P W + G I + F + SCN +++++ NG
Sbjct: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLATH--LSCN-SEHVIVFNGIR 144
Query: 2161 ICSPPLGPPGGNGHFCGS-HASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLA--- 2216
SP L C S + SS + +S N M V F +D S GF + + A
Sbjct: 145 SNSPQL------EKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKV 198
Query: 2217 -----CGGNVYIHDADSAGYVTSPNHP--HNYPPHADCIWILAAPPE--TRIQLQFEDRF 2267
CGG++ G TSP + NY + +C W L+ P + + I + FED F
Sbjct: 199 GCCKLCGGSL---PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFED-F 254
Query: 2268 DIEVTPNCTSNYLELR 2283
+E +C + LE R
Sbjct: 255 YLESHQDCQFDVLEFR 270
Score = 48.9 bits (115), Expect = 9e-05
Identities = 47/187 (25%), Positives = 80/187 (42%), Gaps = 20/187 (10%)
Query: 2580 GNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD-VLEFRVG 2638
G TSP Y + + R EW ++ P I++ F + L +H C + V+ F
Sbjct: 88 GTSTSPNYPNLNPHGRIY--EWRITAPE--GRQITLTFSNLRLATHLSCNSEHVIVFNGI 143
Query: 2639 DADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD---------- 2688
++ P + +LC + + + + + F T+ + GF A ++ ++
Sbjct: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203
Query: 2689 CGG-IQIGDSGVITSPNYPNA--YDSLTHCSSLLEAP-QGHT-ITLTFSDFDIEPHTTCA 2743
CGG + G TSP Y Y +C L P QG++ I + F DF +E H C
Sbjct: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263
Query: 2744 WDSVTVR 2750
+D + R
Sbjct: 264 FDVLEFR 270
>gi|239749791 PREDICTED: similar to hCG1644292 [Homo sapiens]
Length = 671
Score = 457 bits (1176), Expect = e-128
Identities = 241/333 (72%), Positives = 248/333 (74%), Gaps = 69/333 (20%)
Query: 2312 MYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLS 2371
MYLRFRSDNSP H+GFK GLS
Sbjct: 1 MYLRFRSDNSPNHMGFK----------------------------------------GLS 20
Query: 2372 GHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFV 2431
HYLT SFEDFNLQNSSGCEKDFVEIWD HTSGNILGRYC NTIPDS DTSSNTAVVR V
Sbjct: 21 RHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVR-V 79
Query: 2432 TDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRIT 2491
GS QGS GT TSPNYPN NPHGRI EWRITAPEGR+IT
Sbjct: 80 WWGS---------------------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 2492 LMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDG 2551
L F+NLRLA H SCN+EHVIVFNGIRSNSPQLEKLCSSVNVS+EIKSSGNTMKVIFFTDG
Sbjct: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 2552 SRPYGGFTASYTSSEDA-------VCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 2604
SRPYGGFTAS+TSSEDA +CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 2605 NPNQGNSSISIHFEDFYLESHQDCQFDVLEFRV 2637
NPNQGNSSI IHFEDFYLESHQDCQFDVLEFRV
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRV 271
Score = 91.3 bits (225), Expect = 2e-17
Identities = 72/279 (25%), Positives = 120/279 (43%), Gaps = 39/279 (13%)
Query: 1301 SENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYD---GPRQMGRYCGVDLPP 1357
S+N + + + + + +F F+L++ C D++E++D +GRYC +P
Sbjct: 7 SDNSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPD 66
Query: 1358 PGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKEC 1417
T+S+ V + W+ G + G+ G+ +SP +PN P +
Sbjct: 67 STDTSSNTAVVRV---------------WW----GSQ--GSAGTSTSPNYPNLNPHGRIY 105
Query: 1418 IWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQV 1477
W I G I LT + + H CN + + ++ G +SP++ +LC+ S ++
Sbjct: 106 EWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCS--SVNVSSEI 163
Query: 1478 SSTGNELAIRFKTDLSINGRGFNASW----QAVTGGC-----GGIFQAPSGEIHSPNYPS 1528
S+GN + + F TD S GF AS A GC G + P G SP Y
Sbjct: 164 KSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDG 223
Query: 1529 --PYRSNTDCSWVIRVDR--NHRVLLNFTDFDLEPQDSC 1563
Y N +C W + N + ++F DF LE C
Sbjct: 224 VRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262
Score = 88.6 bits (218), Expect = 1e-16
Identities = 76/271 (28%), Positives = 117/271 (43%), Gaps = 40/271 (14%)
Query: 968 HLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS-LGRYCGKSIPPSLTSSGNSLMLVFVT 1026
H + FE F+L+ C D++E++D + + LGRYC +IP S +S N+ ++
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIPDSTDTSSNTAVVRVWW 81
Query: 1027 DSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLI 1086
S GT TSPN+PN P+ +RIT G+ I
Sbjct: 82 GSQ------------------------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQI 117
Query: 1087 AVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGS-NLPPTIISHSNKLWLKFKS 1145
+ F+N L + + ++ + + +G SP L S N+ I S N + + F +
Sbjct: 118 TLTFSNLRLAMHL-SCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176
Query: 1146 DQIDTRSGFSAYWDGSSTG--------CGGNL-TTSSGTFISPNYP--MPYYHSSECYWW 1194
D GF+A S CGG+L T G F SP Y Y + C W
Sbjct: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT 236
Query: 1195 LKSSH--GSAFELEFKDFHLEHHPNCTLDYL 1223
L + + S+ + F+DF+LE H +C D L
Sbjct: 237 LSNPNQGNSSIYIHFEDFYLESHQDCQFDVL 267
Score = 88.2 bits (217), Expect = 1e-16
Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 35/267 (13%)
Query: 749 NFTHVELQCQSDSSQNYIEVRDGET---LLGKVCGNGTISHIKSITNSVWIRFKIDASVE 805
+F LQ S ++++E+ D T +LG+ C N I S +
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN-----------------TIPDSTD 69
Query: 806 KASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGS 865
+S AV +V G + + G SP +PN+ P R W I P+ + I L F+ +
Sbjct: 70 TSSNTAVVRVWWGSQGSA-GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAM 128
Query: 866 SAHCETDYVEIGSSSILGSPENKKYCGT-DIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
C +++V + + SP+ +K C + ++ S I S N + V F S GF A
Sbjct: 129 HLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTAS 188
Query: 925 F-SAED--------LACGEILTESTGTIQSPGHPNV--YPHGINCTWHIL--VQPNHLIH 971
S+ED L G + G SPG+ V Y +NC W + Q N I+
Sbjct: 189 HTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY 248
Query: 972 LMFETFHLEFHYNCTNDYLEVYDTDSE 998
+ FE F+LE H +C D LE SE
Sbjct: 249 IHFEDFYLESHQDCQFDVLEFRVVASE 275
Score = 84.0 bits (206), Expect = 3e-15
Identities = 63/269 (23%), Positives = 115/269 (42%), Gaps = 32/269 (11%)
Query: 1779 SFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSG 1838
SF F L++S C +DFVEI + + +G+++GRYC N+ P
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCANTIP-------------------DS 67
Query: 1839 SGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMD 1898
+ T ++++ G+ G SP +P PH Y+W + + +
Sbjct: 68 TDTSSNTAVVRVWWGSQ--GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125
Query: 1899 IEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTES--FSSTGNSLTFHFYSDSSISGKGF 1956
+ +C + + +++G ++ + C + S S+GN++ F++D S GF
Sbjct: 126 LAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGF 185
Query: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPD--SYSNRVDCTWLIQAP- 2013
+ + D V CGG L F SPG+ +YS ++C W + P
Sbjct: 186 TASHTSSEDADKV---GCCKLCGGSLPNTPEGNFT-SPGYDGVRNYSRNLNCEWTLSNPN 241
Query: 2014 --DSTVELNILSLDIESHRTCAYDSLVIR 2040
+S++ ++ +ESH+ C +D L R
Sbjct: 242 QGNSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 82.0 bits (201), Expect = 1e-14
Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 35/267 (13%)
Query: 515 TFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLR 574
+F F L++ C +F++++D +S LGR+C +++P +S N ++
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNI-LGRYCANTIPDSTDTSSNTAVVRVW----- 80
Query: 575 NGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGT 634
W +Q G G+ SP YP P GR W + +T TF
Sbjct: 81 --------WGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123
Query: 635 LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSV-PPLQTTGPFARIHFHSDSQISDQ 693
L L H CN +++ + +G P L K C++ +V ++++G ++ F +D
Sbjct: 124 LRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183
Query: 694 GFHITYLTSPSDLR------CGGNYTD-PEGELFLPELSGPFTHTR--QCVYMMKQPQ-- 742
GF ++ +S + CGG+ + PEG P G ++R C + + P
Sbjct: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243
Query: 743 GEQIQINFTHVELQCQSDSSQNYIEVR 769
I I+F L+ D + +E R
Sbjct: 244 NSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 81.6 bits (200), Expect = 1e-14
Identities = 69/258 (26%), Positives = 106/258 (41%), Gaps = 45/258 (17%)
Query: 857 NFTVFEIGSSAHCETDYVEIG----SSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVK 912
+F F + +S+ CE D+VEI S +ILG +YC IP + N V
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIWDYHTSGNILG-----RYCANTIPDSTDTSSNTAVVRVWW 81
Query: 913 SSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHL 972
S S GT SP +PN+ PHG W I I L
Sbjct: 82 GSQG----------------------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITL 119
Query: 973 MFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGK-SIPPSLTSSGNSLMLVFVTDSD 1029
F L H +C ++++ V++ + L + C ++ + SSGN++ ++F TD
Sbjct: 120 TFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGS 179
Query: 1030 LAYEGFLINYEAISAA--TACLQDYTDDL-----GTFTSPNFP--NNYPNNWECIYRIT- 1079
Y GF ++ + A C + L G FTSP + NY N C + ++
Sbjct: 180 RPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSN 239
Query: 1080 -VRTGQLIAVHFTNFSLE 1096
+ I +HF +F LE
Sbjct: 240 PNQGNSSIYIHFEDFYLE 257
Score = 80.5 bits (197), Expect = 3e-14
Identities = 71/249 (28%), Positives = 109/249 (43%), Gaps = 39/249 (15%)
Query: 2604 SNPNQ-GNSSISIH-----FEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLP 2657
++PN G +S H FEDF L++ C+ D +E G ++ R C T+P
Sbjct: 9 NSPNHMGFKGLSRHYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGNILGRYCAN---TIP 65
Query: 2658 LVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSS 2717
S +N V + + ++ G +G TSPNYPN
Sbjct: 66 DSTDTS-------SNTAVVRVWWGSQ-----------GSAGTSTSPNYPNLNPHGRIYEW 107
Query: 2718 LLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRT-IQSGS 2776
+ AP+G ITLTFS+ + H +C + V V NG SP + + C + N + I+S
Sbjct: 108 RITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSG 167
Query: 2777 NQLVVTFNSDHSLQGGGFYATW----NTQTLGC-----GGIFHSDNGTIRSPHWP--QNF 2825
N + V F +D S GGF A+ + +GC G + ++ G SP + +N+
Sbjct: 168 NTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNY 227
Query: 2826 PENSRCSWT 2834
N C WT
Sbjct: 228 SRNLNCEWT 236
Score = 79.0 bits (193), Expect = 8e-14
Identities = 67/264 (25%), Positives = 114/264 (43%), Gaps = 43/264 (16%)
Query: 1207 FKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQ 1266
F+DF+L++ C D++ ++D +S + +L + C + P +S ++ +++ G Q
Sbjct: 28 FEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWW--GSQ 84
Query: 1267 GRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD 1326
G G S YPN + W I A G + TF
Sbjct: 85 GSA-------------------GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLR 125
Query: 1327 LEHHINCSTDYLELYDGPR----QMGRYCG-VDLPPPGSTTSSKLQVLLLTDGVGRREKG 1381
L H++C+++++ +++G R Q+ + C V++ ++ + ++V+ TDG R G
Sbjct: 126 LAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG-SRPYGG 184
Query: 1382 FQMQWFVYG----------CGGELSGAT-GSFSSPGFPN--RYPPNKECIWYIRT--DPG 1426
F CGG L G+F+SPG+ Y N C W +
Sbjct: 185 FTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGN 244
Query: 1427 SSIQLTIHDFDVEYHSRCNFDVLE 1450
SSI + DF +E H C FDVLE
Sbjct: 245 SSIYIHFEDFYLESHQDCQFDVLE 268
Score = 78.6 bits (192), Expect = 1e-13
Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 13/187 (6%)
Query: 3044 SSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGAN 3103
S+G TSP Y + P+ + IT + + I L FS+ + SC+ +++ +++G
Sbjct: 86 SAGTSTSPNYPNLN-PHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIR 144
Query: 3104 TSDPLLGKFCGSKR-PPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQT-----LGPQQGC 3157
++ P L K C S +KSS N+M ++F TD + G+ S + +G + C
Sbjct: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204
Query: 3158 GGYLTGS-NNTFASPDSDSNGMYDKNLNCVWIIIAP--VNKVIHLTFNTFALEAASTRQR 3214
GG L + F SP D Y +NLNC W + P N I++ F F LE + Q
Sbjct: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLE---SHQD 261
Query: 3215 CLYDYVK 3221
C +D ++
Sbjct: 262 CQFDVLE 268
Score = 77.8 bits (190), Expect = 2e-13
Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 39/305 (12%)
Query: 1090 FTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQID 1149
F +F+L+ + G DF+EI D + +LG + + +P + + SN ++
Sbjct: 28 FEDFNLQNSSG-CEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRV------ 79
Query: 1150 TRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKD 1209
W GS S+GT SPNYP H W + + G L F +
Sbjct: 80 --------WWGSQG--------SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN 123
Query: 1210 FHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGD-EKPPLIRSSGDSMFIKLRTDEGQQGR 1268
L H +C +++ V++G SNS L +LC I+SSG++M + TD +
Sbjct: 124 LRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYG 183
Query: 1269 GFKAEYRQT--------CE--NVVIVNQTYGILESIGYP--NPYSENQHCNWTI-RATTG 1315
GF A + + C+ + N G S GY YS N +C WT+ G
Sbjct: 184 GFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQG 243
Query: 1316 NTVNYT-FLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDG 1374
N+ Y F F LE H +C D LE + + + + L+ L DG
Sbjct: 244 NSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISRLSGWSECSLERNLFADG 303
Query: 1375 VGRRE 1379
G RE
Sbjct: 304 TGLRE 308
Score = 77.0 bits (188), Expect = 3e-13
Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 49/274 (17%)
Query: 1658 NHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFV 1717
+++T SF F L+ S+ C +DFVEI D H + GRYC +P + S+ +R
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDY-HTSGNILGRYCANTIPDSTDTSSNTAVVRVW 80
Query: 1718 SDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQ 1777
S SAG SP YP++ P W I + G ++
Sbjct: 81 WGSQGSAG----------------------TSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 1778 LSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV---GHTLWVRFI 1833
L+F + +L C+ + V + G + + + C + +N SS + G+T+ V F
Sbjct: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSS---VNVSSEIKSSGNTMKVIFF 175
Query: 1834 SDGSGSGTGFQATF-----------MKIFGNDNIVGTHGKVASPFWP--ENYPHNSNYQW 1880
+DGS GF A+ K+ G G SP + NY N N +W
Sbjct: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235
Query: 1881 TVN----VNASHVVHGRILEMDIEEIQNCYYDKL 1910
T++ N+S +H + +E Q+C +D L
Sbjct: 236 TLSNPNQGNSSIYIH--FEDFYLESHQDCQFDVL 267
Score = 77.0 bits (188), Expect = 3e-13
Identities = 62/186 (33%), Positives = 93/186 (50%), Gaps = 20/186 (10%)
Query: 2228 SAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVD 2287
SAG TSPN+P+ P W + AP +I L F + + + +C S ++ + +G+
Sbjct: 86 SAGTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSN-LRLAMHLSCNSEHVIVFNGIR 144
Query: 2288 SDAPILSKFCGTSLPSSQ-WSSGEVMYLRFRSDNSPTHVGFKAKYSIAQ----------C 2336
S++P L K C + SS+ SSG M + F +D S + GF A ++ ++ C
Sbjct: 145 SNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLC 204
Query: 2337 GGRVPG-QSGVVESIGHPTL-PYRDNLFCEWHL----QGLSGHYLTISFEDFNLQNSSGC 2390
GG +P G S G+ + Y NL CEW L QG S Y I FEDF L++ C
Sbjct: 205 GGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIY--IHFEDFYLESHQDC 262
Query: 2391 EKDFVE 2396
+ D +E
Sbjct: 263 QFDVLE 268
Score = 73.9 bits (180), Expect = 3e-12
Identities = 53/175 (30%), Positives = 81/175 (46%), Gaps = 14/175 (8%)
Query: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
G SP +P+ + + +TAP+ I+L F +L + + C ++ + V NG SNS
Sbjct: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNS 147
Query: 3464 PLLGKYCGTL-LPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG--------CGGT 3514
P L K C ++ + + + S N + + F +D G+ TSS CGG+
Sbjct: 148 PQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGS 207
Query: 3515 LYG-DRGSFTSPGYPG--TYPNNTYCEWVLVAP--AGRLVTINFYFISIDDPGDC 3564
L G+FTSPGY G Y N CEW L P + I+F ++ DC
Sbjct: 208 LPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDC 262
Score = 73.2 bits (178), Expect = 4e-12
Identities = 45/187 (24%), Positives = 80/187 (42%), Gaps = 23/187 (12%)
Query: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490
H ++ F ++NS C DF+E+ + S + +LG+YC +P+ + +N +R
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78
Query: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVT 3550
+W S G G+ TSP YP P+ EW + AP GR +T
Sbjct: 79 ------------VWWGSQ--------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 3551 INFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADY 3610
+ F + + C ++ +++G ++SP C + +S N + + F D
Sbjct: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 3611 ARRPSAF 3617
+R F
Sbjct: 179 SRPYGGF 185
Score = 72.4 bits (176), Expect = 8e-12
Identities = 65/270 (24%), Positives = 106/270 (39%), Gaps = 48/270 (17%)
Query: 1432 TIHDFDVEYHSRCNFDVLEIYGGPDFHSPR--IAQLCTQRSPENPMQVSSTGNELAIRFK 1489
+ DF+++ S C D +EI+ D+H+ + + C P++
Sbjct: 27 SFEDFNLQNSSGCEKDFVEIW---DYHTSGNILGRYCANTIPDS---------------- 67
Query: 1490 TDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVL 1549
TD S N W + Q +G SPNYP+ W I ++
Sbjct: 68 TDTSSNTAVVRVWWGS---------QGSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 1550 LNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGP 1605
L F++ L SC ++ ++G+ S +L + C +++ I SSGN++ + F +
Sbjct: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 1606 SRQNRGFRAQFRQA-----------CGGHILTSSFDTVSSPRFPA--NYPNNQNCSWIIQ 1652
SR GF A + CGG + + +SP + NY N NC W +
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 1653 AQPPLN-HITLSFTHFELERSTTCARDFVE 1681
N I + F F LE C D +E
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268
Score = 65.9 bits (159), Expect = 7e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 16/165 (9%)
Query: 502 WVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS-SLPHELLSS 560
W I G+ + +TF+ RL +C E + V++G S++ QL + C S ++ E+ SS
Sbjct: 107 WRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSS 166
Query: 561 DNALYFHLYSEHLRNGRGFTVRWETQQPE--------CGGILTG-PYGSIKSPGYPG--N 609
N + +++ R GFT + + CGG L P G+ SPGY G N
Sbjct: 167 GNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRN 226
Query: 610 YPPGRDCVWIVVTSP---DLLVTFTFGTLSLEHHDDCNKDYLEIR 651
Y +C W +++P + + F LE H DC D LE R
Sbjct: 227 YSRNLNCEW-TLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFR 270
Score = 62.0 bits (149), Expect = 1e-08
Identities = 66/264 (25%), Positives = 107/264 (40%), Gaps = 46/264 (17%)
Query: 2725 HTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFN 2784
H +T +F DF+++ + C D V + + + + I+G+YC N+ P + + SN VV
Sbjct: 22 HYLTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVR-- 78
Query: 2785 SDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLE 2844
W +Q GT SP++P P W + + +
Sbjct: 79 -----------VWWGSQ---------GSAGTSTSPNYPNLNPHGRIYEWRITAPEGRQIT 118
Query: 2845 ISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPS-NTFTAVFQ 2903
++F N L + C + V V+ G + L C +V I S NT +F
Sbjct: 119 LTFSN--LRLAMHLSCNSEHVIVFNGIRS-NSPQLEKLCSSVNVSSEIKSSGNTMKVIFF 175
Query: 2904 SQ-EAPAQGFSASFVSR-----------CGSNFTG-PSGYIISPNYP--KQYDNNMNCTY 2948
+ P GF+AS S CG + P G SP Y + Y N+NC +
Sbjct: 176 TDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEW 235
Query: 2949 VIEANP---LSVVLLTFVSFHLEA 2969
+ +NP S + + F F+LE+
Sbjct: 236 TL-SNPNQGNSSIYIHFEDFYLES 258
Score = 61.2 bits (147), Expect = 2e-08
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 18/161 (11%)
Query: 1993 SPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLA 2051
SP +P+ + W I AP+ + L +L + H +C + +++ +G + + QL
Sbjct: 92 SPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLE 151
Query: 2052 VLCGR-EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKS-----------CGGYL-HA 2098
LC + I+S+G M + F +D S GF AS S CGG L +
Sbjct: 152 KLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT 211
Query: 2099 DRGIITSPKYP--ETYPSNLNCSWHVL--VQSGLTIAVHFE 2135
G TSP Y Y NLNC W + Q +I +HFE
Sbjct: 212 PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFE 252
Score = 60.8 bits (146), Expect = 2e-08
Identities = 72/292 (24%), Positives = 119/292 (40%), Gaps = 48/292 (16%)
Query: 3080 FSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQT 3139
F DF++ S+ C D++ I+D +TS +LG++C + P + +S+N+ ++
Sbjct: 28 FEDFNLQNSSGCEKDFVEIWD-YHTSGNILGRYCANTIPDSTDTSSNTAVV--------- 77
Query: 3140 AKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHL 3199
+ W S QG G T N +P +Y+ W I AP + I L
Sbjct: 78 -RVWWGS--------QGSAGTSTSPNYPNLNP---HGRIYE------WRITAPEGRQITL 119
Query: 3200 TFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGS-TVPAPFISSGNFLTVQFIS 3258
TF+ L + C ++V +++G N+ C S V + SSGN + V F +
Sbjct: 120 TFSNLRL---AMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFT 176
Query: 3259 DLTLEREGFNATYTIMD--------MPCGGTYNATWTPQNISSPNSSDPDVPFS---ICT 3307
D + GF A++T + CGG+ T N +SP D +S C
Sbjct: 177 DGSRPYGGFTASHTSSEDADKVGCCKLCGGSLPNT-PEGNFTSP-GYDGVRNYSRNLNCE 234
Query: 3308 WVIDSPPHQQVKITVWALQL---TSQDCTQNYLQLQDSPQGHGNSRFQFCGR 3356
W + +P I + + QDC + L+ + H F R
Sbjct: 235 WTLSNPNQGNSSIYIHFEDFYLESHQDCQFDVLEFRVVASEHWKVPFSLISR 286
Score = 59.7 bits (143), Expect = 5e-08
Identities = 67/270 (24%), Positives = 107/270 (39%), Gaps = 47/270 (17%)
Query: 628 VTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSD 687
+T +F +L++ C KD++EI D + +LG++C T+ A +
Sbjct: 24 LTNSFEDFNLQNSSGCEKDFVEIWDYHTSGN-ILGRYCANTIPDSTDTSSNTAVVRVWWG 82
Query: 688 SQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQ 747
SQ S G T P P L+ H R + + P+G QI
Sbjct: 83 SQGS-----------------AGTSTSPN----YPNLN---PHGRIYEWRITAPEGRQIT 118
Query: 748 INFTH----VELQCQSDSSQNYIEVRDGETLLGKVCGNGTI-SHIKSITNSVWIRFKIDA 802
+ F++ + L C S+ + +R L K+C + + S IKS N++ + F D
Sbjct: 119 LTFSNLRLAMHLSCNSEHVIVFNGIRSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDG 178
Query: 803 SVEKASFRAVYQVA-----------CGDEL--TGEGVIRSPFFPNV--YPGERTCRWTIH 847
S F A + + CG L T EG SP + V Y C WT+
Sbjct: 179 SRPYGGFTASHTSSEDADKVGCCKLCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS 238
Query: 848 QPQ--SQVILLNFTVFEIGSSAHCETDYVE 875
P + I ++F F + S C+ D +E
Sbjct: 239 NPNQGNSSIYIHFEDFYLESHQDCQFDVLE 268
Score = 54.3 bits (129), Expect = 2e-06
Identities = 56/196 (28%), Positives = 82/196 (41%), Gaps = 26/196 (13%)
Query: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160
G TSP YP P W + G I + F + SCN +++++ NG
Sbjct: 88 GTSTSPNYPNLNPHGRIYEWRITAPEGRQITLTFSNLRLAMH--LSCN-SEHVIVFNGIR 144
Query: 2161 ICSPPLGPPGGNGHFCGS-HASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLA--- 2216
SP L C S + SS + +S N M V F +D S GF + + A
Sbjct: 145 SNSPQL------EKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKV 198
Query: 2217 -----CGGNVYIHDADSAGYVTSPNHP--HNYPPHADCIWILAAPPE--TRIQLQFEDRF 2267
CGG++ G TSP + NY + +C W L+ P + + I + FED F
Sbjct: 199 GCCKLCGGSL---PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFED-F 254
Query: 2268 DIEVTPNCTSNYLELR 2283
+E +C + LE R
Sbjct: 255 YLESHQDCQFDVLEFR 270
Score = 48.1 bits (113), Expect = 2e-04
Identities = 47/187 (25%), Positives = 79/187 (42%), Gaps = 20/187 (10%)
Query: 2580 GNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD-VLEFRVG 2638
G TSP Y + + R EW ++ P I++ F + L H C + V+ F
Sbjct: 88 GTSTSPNYPNLNPHGRIY--EWRITAPE--GRQITLTFSNLRLAMHLSCNSEHVIVFNGI 143
Query: 2639 DADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD---------- 2688
++ P + +LC + + + + + F T+ + GF A ++ ++
Sbjct: 144 RSNSPQLEKLCSSVNVSSEIKSSGNTMKVIFFTDGSRPYGGFTASHTSSEDADKVGCCKL 203
Query: 2689 CGG-IQIGDSGVITSPNYPNA--YDSLTHCSSLLEAP-QGHT-ITLTFSDFDIEPHTTCA 2743
CGG + G TSP Y Y +C L P QG++ I + F DF +E H C
Sbjct: 204 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSIYIHFEDFYLESHQDCQ 263
Query: 2744 WDSVTVR 2750
+D + R
Sbjct: 264 FDVLEFR 270
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 320 bits (820), Expect = 2e-86
Identities = 223/744 (29%), Positives = 349/744 (46%), Gaps = 98/744 (13%)
Query: 1551 NFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGP-SRQN 1609
NF + +S YD S M T R + I+ S + +R G +R +
Sbjct: 275 NFLKMEPGEVNSLGERYD-FDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
Query: 1610 RGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSF 1664
+G AQ R+ ACG L S +SSP FP YP+ +C W + P I L+F
Sbjct: 334 KGDIAQARKLYRCPACG-ETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPG-EKIVLNF 391
Query: 1665 THFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISA 1724
T +L +S+ C D++E+ DG +PL GR+CG +P +TS S + + F S S+
Sbjct: 392 TTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVG 451
Query: 1725 GGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQ 1784
GF A CGG EG SP YPD Y P ECVW I S + L+F SF+
Sbjct: 452 KGFAAVYEA---ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFE 508
Query: 1785 LEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGF 1843
+E +C+ D++E+R+G + L+GR+CG P + S +TLW++F+SDG+ + GF
Sbjct: 509 IERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRS-TSNTLWMKFVSDGTVNKAGF 567
Query: 1844 QATFMK--------------------------------IFGNDN----------IVGTHG 1861
A F K G D + +G
Sbjct: 568 AANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNG 627
Query: 1862 KVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHAR 1921
+ +P WP+ YP N N W V + + + ++E + C YD + I+ G S ++
Sbjct: 628 TITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESK 687
Query: 1922 LIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA----VDAPDG-----VLP 1971
L G +CG + E +S N++ F SD+++S KGF +F+ +G +
Sbjct: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747
Query: 1972 TIAPGAC---GGFL---------------RTGDAPVFLFSPGWPDSYSNRVDCTWLIQA- 2012
T+ C GF+ + + SP WPD Y +R +CTW I A
Sbjct: 748 TMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISAT 807
Query: 2013 PDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIR 2072
P ++L +IE H+ CAYD L + DG+ + L LCG +IP P+ +TG MF+R
Sbjct: 808 PGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVR 867
Query: 2073 FTSDSSVTRAGFNASFHKSCGGYLHAD---RGIITSPKYPE-TYPSNLNCSWHVLVQSGL 2128
F SD+SV R GF A+ CGG L A+ R + + ++ + YP ++C W ++ + G
Sbjct: 868 FVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGS 927
Query: 2129 TIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSD 2188
+ + F Q F++ ++ C DY+ L +G D + G G FCGS +++
Sbjct: 928 RLELSF-QTFEVEE-EADCGY-DYVELFDGLDSTAV------GLGRFCGSGPPEEIYSIG 978
Query: 2189 NQMFVQFISDHSNEGQGFKIKYEA 2212
+ + + F +D + +GF I+Y++
Sbjct: 979 DSVLIHFHTDDTINKKGFHIRYKS 1002
Score = 310 bits (793), Expect = 2e-83
Identities = 200/673 (29%), Positives = 312/673 (46%), Gaps = 110/673 (16%)
Query: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
CG L + G+ SSPGFPN YP CIW + PG I L D+ S C +D +E
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
+ G SP + + C + PE ++ST + + I F++ + G+GF A ++A+ C
Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPE---VLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---C 462
Query: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
GG + G+I SPNYP YR +C W I V ++ V L F F++E D+C Y
Sbjct: 463 GGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEV 522
Query: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
DG S + R CG ++ I S+ N+L+++F S + GF A F
Sbjct: 523 RDGTSENSPLIGRFCGYDK-PEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
ACGG +LT T+++P +P YP
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGG-LLTKLNGTITTPGWPKEYPP 640
Query: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
N+NC W + A P I++ F FELE + C D+VEI G ++ L G++CG ++P
Sbjct: 641 NKNCVWQVVA-PTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPE 699
Query: 1704 PITSFSSALTLRFVSDSSISAGGFHTTVTASVSAC----GGT---------FYMAE---- 1746
ITS + + + F SD+++S GF + C GG YM +
Sbjct: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNG 759
Query: 1747 -----------------------GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISF 1783
G+ SP +PD YP EC W I ++PG+R++L+F F
Sbjct: 760 FVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEF 819
Query: 1784 QLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG 1842
++E Q+C+ D +E+ +G ++GR CGN P + G+ ++VRF+SD S G
Sbjct: 820 EIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIP-DPLVATGNKMFVRFVSDASVQRKG 878
Query: 1843 FQATF-------MKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRIL 1895
FQAT +K + +H + F NYP + +W + +
Sbjct: 879 FQATHSTECGGRLKAESKPRDLYSHAQ----FGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
Query: 1896 EMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGK 1954
++EE +C YD + ++DG A +G +CG+ E S G+S+ HF++D +I+ K
Sbjct: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKK 994
Query: 1955 GFLLEWFAVDAPD 1967
GF + + ++ PD
Sbjct: 995 GFHIRYKSIRYPD 1007
Score = 308 bits (788), Expect = 8e-83
Identities = 202/667 (30%), Positives = 309/667 (46%), Gaps = 102/667 (15%)
Query: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
ACGE L ES G + SPG PN YP +C W + V P I L F T L C DY+
Sbjct: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
EV D S LGR+CG +P LTS+ + + + F + S+ +GF YEAI C
Sbjct: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-----C 462
Query: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
+ + G SPN+P++Y EC+++ITV + + F +F +E N D+LE
Sbjct: 463 GGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERH-DNCAYDYLE 521
Query: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW---------- 1158
+RDG E SPL+G F G + P I S SN LW+KF SD ++GF+A +
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 1159 ------------------------------DGSSTGCGGNLTTSSGTFISPNYPMPYYHS 1188
CGG LT +GT +P +P Y +
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
Query: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
C W + + ++F+ F LE + C DY+ ++ G SS S L + CG E P +I
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
Query: 1249 RSSGDSMFIKLRTDEGQQGRGFKA-------------------------EYRQTCENVVI 1283
S ++M I+ ++D +GFKA Y C N +
Sbjct: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFV 761
Query: 1284 ----------------VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDL 1327
++ G++ S +P+ Y + C W I AT G+ + F F++
Sbjct: 762 LHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEI 821
Query: 1328 EHHINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQ 1383
E H C+ D+LE++DG + +GR CG +P P T +K+ V ++D +R KGFQ
Sbjct: 822 EQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQR-KGFQ 880
Query: 1384 MQWFVYGCGGEL---SGATGSFSSPGF-PNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
CGG L S +S F N YP +C W + ++ GS ++L+ F+VE
Sbjct: 881 ATHST-ECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVE 939
Query: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
+ C +D +E++ G D + + + C PE ++ S G+ + I F TD +IN +GF
Sbjct: 940 EEADCGYDYVELFDGLDSTAVGLGRFCGSGPPE---EIYSIGDSVLIHFHTDDTINKKGF 996
Query: 1500 NASWQAV 1506
+ ++++
Sbjct: 997 HIRYKSI 1003
Score = 308 bits (788), Expect = 8e-83
Identities = 190/666 (28%), Positives = 313/666 (46%), Gaps = 107/666 (16%)
Query: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
AC + + G +SP FPN YP+ CI+R++V G+ I ++FT L ++ +Y D+
Sbjct: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY-DY 406
Query: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
+E+RDG + KSPLLG F G LP + S +++W++F+S GF+A ++ CG
Sbjct: 407 IEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---CG 463
Query: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
G + + G SPNYP Y EC W + S L F+ F +E H NC DYL V
Sbjct: 464 GEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVR 523
Query: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY------------ 1274
DG S NS L+ + CG +KP IRS+ +++++K +D GF A +
Sbjct: 524 DGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDR 583
Query: 1275 ---------------------------RQTCENVV--IVNQTYGILESIGYPNPYSENQH 1305
R++CE ++ + G + + G+P Y N++
Sbjct: 584 GGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKN 643
Query: 1306 CNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGST 1361
C W + A T ++ F F+LE + C DY+E++ G + G++CG ++P ++
Sbjct: 644 CVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITS 703
Query: 1362 TSSKLQVLLLTDGVGRREKGFQMQWFV---------YGCGGELSGATGSF---------- 1402
+ +++ +D + KGF+ +F GC E GS+
Sbjct: 704 QFNNMRIEFKSDNTVSK-KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL 762
Query: 1403 -----------------------SSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
+SP +P++YP KEC W I PG I+L +F++E
Sbjct: 763 HDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIE 822
Query: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
H C +D LE++ G SP + +LC + P+ + +TGN++ +RF +D S+ +GF
Sbjct: 823 QHQECAYDHLEVFDGETEKSPILGRLCGNKIPD---PLVATGNKMFVRFVSDASVQRKGF 879
Query: 1500 NASWQAVTGGCGGIFQAPSGE----IHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDF 1555
A+ CGG +A S H+ + Y DC W++ +R R+ L+F F
Sbjct: 880 QATHST---ECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTF 936
Query: 1556 DLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRG 1611
++E + C + +DGL ST L R CG I S G+S+ + F + + +G
Sbjct: 937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGP-PEEIYSIGDSVLIHFHTDDTINKKG 995
Query: 1612 FRAQFR 1617
F +++
Sbjct: 996 FHIRYK 1001
Score = 291 bits (744), Expect = 1e-77
Identities = 198/674 (29%), Positives = 311/674 (46%), Gaps = 112/674 (16%)
Query: 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSI 1918
++G ++SP +P YP ++ W V+V + MD+ + C+YD + + DG
Sbjct: 356 SNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWR 415
Query: 1919 HARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGA 1977
+ L+G +CG + E +ST + + F S S+ GKGF + A+
Sbjct: 416 KSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-------------- 461
Query: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDS 2036
CGG +R + + SP +PD Y +C W I +S V L S +IE H CAYD
Sbjct: 462 CGGEIRKNEGQIQ--SPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
Query: 2037 LVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK------ 2090
L +RDG + + + CG + P IRST ++++F SD +V +AGF A+F K
Sbjct: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579
Query: 2091 -------------------------------------SCGGYLHADRGIITSPKYPETYP 2113
+CGG L G IT+P +P+ YP
Sbjct: 580 KPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYP 639
Query: 2114 SNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNG 2173
N NC W V+ + I+V FE F G+ C DY+ + +G S +G
Sbjct: 640 PNKNCVWQVVAPTQYRISVKFE--FFELEGNEVCKY-DYVEIWSGLSSESKL------HG 690
Query: 2174 HFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLAC----GG---------- 2219
FCG+ + + N M ++F SD++ +GFK + + C GG
Sbjct: 691 KFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMG 750
Query: 2220 -------NVYI-----HDADSA----------GYVTSPNHPHNYPPHADCIWILAAPPET 2257
N ++ HD A G +TSPN P YP +C W ++A P
Sbjct: 751 SYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGH 810
Query: 2258 RIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFR 2317
RI+L F + F+IE C ++LE+ DG +PIL + CG +P ++G M++RF
Sbjct: 811 RIKLAFSE-FEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869
Query: 2318 SDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTL---PYRDNLFCEWHLQGLSGHY 2374
SD S GF+A +S +CGGR+ +S + H Y + CEW L G
Sbjct: 870 SDASVQRKGFQATHS-TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSR 928
Query: 2375 LTISFEDFNLQNSSGCEKDFVEIWDNHTSGNI-LGRYCGNTIPDSIDTSSNTAVVRFVTD 2433
L +SF+ F ++ + C D+VE++D S + LGR+CG+ P+ I + ++ ++ F TD
Sbjct: 929 LELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTD 988
Query: 2434 GSVTASGFRLRFES 2447
++ GF +R++S
Sbjct: 989 DTINKKGFHIRYKS 1002
Score = 288 bits (738), Expect = 5e-77
Identities = 188/670 (28%), Positives = 293/670 (43%), Gaps = 109/670 (16%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
CG Q +G + SP +P+ Y S T C W + V +++LNFT DL C Y
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
DG L R CG ++L + S+ + +++ F+S + +GF A + CGG I
Sbjct: 409 VRDGYWRKSPLLGRFCG-DKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIR 467
Query: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
+ + SP +P +Y + C W I H+ L+F FE+ER CA D++E+ DG
Sbjct: 468 KNE-GQIQSPNYPDDYRPMKECVWKITVSESY-HVGLTFQSFEIERHDNCAYDYLEVRDG 525
Query: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV-------------- 1731
E++PL GR+CG D P I S S+ L ++FVSD +++ GF
Sbjct: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
Query: 1732 --------------------------TASVSACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
+ +ACGG G +PG+P YPPN CV
Sbjct: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
Query: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
W +V+ R+ + F F+LE ++ C D+VEI G ++ L G++CG P +S
Sbjct: 646 WQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQF 705
Query: 1825 GHTLWVRFISDGSGSGTGFQATFMK------------------------------IFGND 1854
+ + + F SD + S GF+A F +D
Sbjct: 706 -NNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHD 764
Query: 1855 N------------IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEI 1902
N I G + SP WP+ YP W ++ H + E +IE+
Sbjct: 765 NKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQH 824
Query: 1903 QNCYYDKLRIYDGPSIHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWF 1961
Q C YD L ++DG + + ++G CG + + +TGN + F SD+S+ KGF
Sbjct: 825 QECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF----- 879
Query: 1962 AVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPG--WPDSYSNRVDCTW-LIQAPDSTVE 2018
CGG L+ P L+S ++Y +VDC W L+ S +E
Sbjct: 880 ---------QATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLE 930
Query: 2019 LNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSS 2078
L+ + ++E C YD + + DG ++ A L CG P I S G+ + I F +D +
Sbjct: 931 LSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDT 990
Query: 2079 VTRAGFNASF 2088
+ + GF+ +
Sbjct: 991 INKKGFHIRY 1000
Score = 288 bits (736), Expect = 9e-77
Identities = 191/669 (28%), Positives = 300/669 (44%), Gaps = 95/669 (14%)
Query: 807 ASFRAVYQV-ACGDELT-GEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
A R +Y+ ACG+ L G + SP FPN YP C W + + I+LNFT ++
Sbjct: 338 AQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLY 397
Query: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
S+ C DY+E+ SP ++CG +P +TS + +++ F SS+ GF A
Sbjct: 398 KSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
Query: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
+ A CG + ++ G IQSP +P+ Y C W I V ++ + L F++F +E H N
Sbjct: 458 YEA---ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN 514
Query: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
C DYLEV D SE S +GR+CG P + S+ N+L + FV+D + GF N+
Sbjct: 515 CAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE 574
Query: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
+ S AC T GT T+P +
Sbjct: 575 EDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGW 634
Query: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLE-EAIGNYYTDFLEIRDGGYEKSPLLGIF 1123
P YP N C++++ T I+V F F LE + Y D++EI G +S L G F
Sbjct: 635 PKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY--DYVEIWSGLSSESKLHGKF 692
Query: 1124 YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW------------------------- 1158
G+ +P I S N + ++FKSD ++ GF A++
Sbjct: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSY 752
Query: 1159 ---------------DGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAF 1203
D C + + SG SPN+P Y EC W + ++ G
Sbjct: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
Query: 1204 ELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDE 1263
+L F +F +E H C D+L V+DG + S +L +LCG++ P + ++G+ MF++ +D
Sbjct: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
Query: 1264 GQQGRGFKAEYRQTCENVVIVNQTYGILESIGY--PNPYSENQHCNWTIRATTGNTVNYT 1321
Q +GF+A + C + L S N Y C W + + G+ + +
Sbjct: 873 SVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELS 932
Query: 1322 FLAFDLEHHINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGR 1377
F F++E +C DY+EL+DG +GR+CG P + + + TD
Sbjct: 933 FQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDT-I 991
Query: 1378 REKGFQMQW 1386
+KGF +++
Sbjct: 992 NKKGFHIRY 1000
Score = 286 bits (731), Expect = 3e-76
Identities = 190/664 (28%), Positives = 305/664 (45%), Gaps = 110/664 (16%)
Query: 1284 VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG 1343
+ ++ G L S G+PN Y HC W + T G + F DL C DY+E+ DG
Sbjct: 353 LQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDG 412
Query: 1344 PRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDG--VGRREKGFQMQWFVYGCGGELSG 1397
+ +GR+CG LP ++T S++ + + VG KGF + CGGE+
Sbjct: 413 YWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVG---KGFAAVYEAI-CGGEIRK 468
Query: 1398 ATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDF 1457
G SP +P+ Y P KEC+W I + LT F++E H C +D LE+ G
Sbjct: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSE 528
Query: 1458 HSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASW-------------- 1503
+SP I + C PE+ + ST N L ++F +D ++N GF A++
Sbjct: 529 NSPLIGRFCGYDKPED---IRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
Query: 1504 --------------------------QAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCS 1537
++ CGG+ +G I +P +P Y N +C
Sbjct: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
Query: 1538 WVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSS 1593
W + +R+ + F F+LE + C + + GLSS + CG E + I S
Sbjct: 646 WQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE-VPEVITSQ 704
Query: 1594 GNSLFLRFQSGPSRQNRGFRAQFR--------------------------QACGGHILT- 1626
N++ + F+S + +GF+A F Q G +L
Sbjct: 705 FNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHD 764
Query: 1627 ---------------SSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELER 1671
S ++SP +P YP+ + C+W I A P + I L+F+ FE+E+
Sbjct: 765 NKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG-HRIKLAFSEFEIEQ 823
Query: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV 1731
CA D +E+ DG E +P+ GR CG +P P+ + + + +RFVSD+S+ GF T
Sbjct: 824 HQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
Query: 1732 TASVSACGGTF---YMAEGIFNSPGYPD-IYPPNVECVWNIVSSPGNRLQLSFISFQLED 1787
+ + CGG +++ + D YP V+C W +VS G+RL+LSF +F++E+
Sbjct: 884 S---TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
Query: 1788 SQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQAT 1846
DC D+VE+ +G ++T +GR+CG+ P SI G ++ + F +D + + GF
Sbjct: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSI-GDSVLIHFHTDDTINKKGFHIR 999
Query: 1847 FMKI 1850
+ I
Sbjct: 1000 YKSI 1003
Score = 280 bits (715), Expect = 2e-74
Identities = 191/679 (28%), Positives = 304/679 (44%), Gaps = 111/679 (16%)
Query: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
+CG L G ++SP +P YPS +C W V V G I ++F + SS
Sbjct: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT---MDLYKSSLCWY 404
Query: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
DY+ +R+G SP LG FCG L ++D++M+++F S + G+GF Y
Sbjct: 405 DYIEVRDGYWRKSPLLG------RFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
Query: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270
EA CGG + ++ G + SPN+P +Y P +C+W + + L F+ F+IE
Sbjct: 459 EA---ICGGEIRKNE----GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIE 510
Query: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330
NC +YLE+RDG ++P++ +FCG P S+ ++++F SD + GF A
Sbjct: 511 RHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAAN 570
Query: 2331 Y------------------------------------------SIAQCGGRVPGQSGVVE 2348
+ A CGG + +G +
Sbjct: 571 FFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTIT 630
Query: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNIL- 2407
+ G P Y N C W + + + +++ FE F L+ + C+ D+VEIW +S + L
Sbjct: 631 TPGWPK-EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLH 689
Query: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGD------------ 2455
G++CG +P+ I + N + F +D +V+ GF+ F S +EC D
Sbjct: 690 GKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTM 749
Query: 2456 ----------------------------LQGSIGTFTSPNYPNPNPHGRICEWRITAPEG 2487
+ G TSPN+P+ P + C W I+A G
Sbjct: 750 GSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG 809
Query: 2488 RRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIF 2547
RI L F+ + H C +H+ VF+G SP L +LC + + + + ++GN M V F
Sbjct: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRF 868
Query: 2548 FTDGSRPYGGFTASYTSSEDAVCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 2606
+D S GF A++++ CGG L + + S G NY ++CEW L
Sbjct: 869 VSDASVQRKGFQATHSTE----CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLL--V 922
Query: 2607 NQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLCGPSKPTLPLVIPYSQV 2665
++ S + + F+ F +E DC +D +E G D+ + R CG P I S V
Sbjct: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDS-V 981
Query: 2666 WIHFVTNERVEHIGFHAKY 2684
IHF T++ + GFH +Y
Sbjct: 982 LIHFHTDDTINKKGFHIRY 1000
Score = 268 bits (684), Expect = 9e-71
Identities = 189/681 (27%), Positives = 295/681 (43%), Gaps = 119/681 (17%)
Query: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
ACG L+ + L SPG+P+ Y + C W + P + LN ++D+ C YD
Sbjct: 348 ACGETLQESNGN--LSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
Query: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
+ +RDG + L CG ++P + ST M+I F S S+ GF A + CGG
Sbjct: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGE 465
Query: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
+ + G I SP YP+ Y C W + V + + F Q F+I D+ DYL +
Sbjct: 466 IRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTF-QSFEIERHDNCAY--DYLEV 522
Query: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
R+G SP + G FCG + ++ N ++++F+SD + GF +
Sbjct: 523 RDGTSENSPLI------GRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEED 576
Query: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
E + L ACGG + G +T+P
Sbjct: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLL----TKLNGTITTP 632
Query: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
P YPP+ +C+W + AP + RI ++FE F++E C +Y+E+ G+ S++ + K
Sbjct: 633 GWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGNEVCKYDYVEIWSGLSSESKLHGK 691
Query: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY------------------------ 2331
FCG +P S M + F+SDN+ + GFKA +
Sbjct: 692 FCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGS 751
Query: 2332 ------------------SIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGH 2373
A+C ++ SG++ S P Y C W + GH
Sbjct: 752 YMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPD-KYPSRKECTWEISATPGH 810
Query: 2374 YLTISFEDFNLQNSSGCEKDFVEIWDNHTSGN-ILGRYCGNTIPDSIDTSSNTAVVRFVT 2432
+ ++F +F ++ C D +E++D T + ILGR CGN IPD + + N VRFV+
Sbjct: 811 RIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVS 870
Query: 2433 DGSVTASGFRLRFESSMEECGGDLQG--------SIGTFTSPNYPNPNPHGRI-CEWRIT 2483
D SV GF+ + ECGG L+ S F NYP G++ CEW +
Sbjct: 871 DASVQRKGFQATHST---ECGGRLKAESKPRDLYSHAQFGDNNYP-----GQVDCEWLLV 922
Query: 2484 APEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTM 2543
+ G R+ L F + C ++V +F+G+ S + L + C S EI S G+++
Sbjct: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS-GPPEEIYSIGDSV 981
Query: 2544 KVIFFTDGSRPYGGFTASYTS 2564
+ F TD + GF Y S
Sbjct: 982 LIHFHTDDTINKKGFHIRYKS 1002
Score = 267 bits (682), Expect = 2e-70
Identities = 185/680 (27%), Positives = 285/680 (41%), Gaps = 102/680 (15%)
Query: 459 TRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRI 514
TRL G + Q + CGE+L NG+ S GY +C W + G+ + +
Sbjct: 330 TRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVL 389
Query: 515 TFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLR 574
FT L C +++++V DG + LGRFCG LP L S+D+ ++ S
Sbjct: 390 NFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNW 449
Query: 575 NGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGT 634
G+GF +E CGG + G I+SP YP +Y P ++CVW + S V TF +
Sbjct: 450 VGKGFAAVYEAI---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS 506
Query: 635 LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQG 694
+E HD+C DYLE+RDG PL+G+FC +++T + F SD ++ G
Sbjct: 507 FEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG 566
Query: 695 FHITYLTSPS--------------------------------------DLRCGGNYTDPE 716
F + + CGG T
Sbjct: 567 FAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLN 626
Query: 717 GELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----E 772
G + P + + CV+ + P +I + F EL+ +Y+E+ G
Sbjct: 627 GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES 686
Query: 773 TLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY------------------- 813
L GK CG I S N++ I FK D +V K F+A +
Sbjct: 687 KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECV 746
Query: 814 ------------------------QVACGDEL-TGEGVIRSPFFPNVYPGERTCRWTIHQ 848
+ C ++ + G+I SP +P+ YP + C W I
Sbjct: 747 NTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISA 806
Query: 849 PQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYV 908
I L F+ FEI C D++E+ SP + CG IP + + N ++V
Sbjct: 807 TPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFV 866
Query: 909 TFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGH----PNVYPHGINCTWHILV 964
FV +S + GF A S E CG L + H N YP ++C W ++
Sbjct: 867 RFVSDASVQRKGFQATHSTE---CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS 923
Query: 965 QPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLML 1022
+ + L F+TF +E +C DY+E++D T+ LGR+CG P + S G+S+++
Sbjct: 924 ERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
Query: 1023 VFVTDSDLAYEGFLINYEAI 1042
F TD + +GF I Y++I
Sbjct: 984 HFHTDDTINKKGFHIRYKSI 1003
Score = 265 bits (677), Expect = 6e-70
Identities = 184/679 (27%), Positives = 304/679 (44%), Gaps = 118/679 (17%)
Query: 2216 ACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNC 2275
ACG + +S G ++SP P+ YP + CIW ++ P +I L F D+ + C
Sbjct: 348 ACGETLQ----ESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT-MDLYKSSLC 402
Query: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQ 2335
+Y+E+RDG +P+L +FCG LP S+ M++ FRS ++ GF A Y A
Sbjct: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE-AI 461
Query: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395
CGG + G ++S +P YR C W + +++ ++F+ F ++ C D++
Sbjct: 462 CGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYL 520
Query: 2396 EIWDNHTSGN-ILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE--- 2451
E+ D + + ++GR+CG P+ I ++SNT ++FV+DG+V +GF F +E
Sbjct: 521 EVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
Query: 2452 -------------------------------------CGGDLQGSIGTFTSPNYPNPNPH 2474
CGG L GT T+P +P P
Sbjct: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPP 640
Query: 2475 GRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSN 2534
+ C W++ AP RI++ F L + C ++V +++G+ S S K C + V
Sbjct: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGA-EVPE 699
Query: 2535 EIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAV------CGGSLPNT----------- 2577
I S N M++ F +D + GF A + S +D C NT
Sbjct: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNG 759
Query: 2578 ---------------------PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIH 2616
P G TSP + Y C W +S I +
Sbjct: 760 FVLHDNKHDCKEAECEQKIHSPSGLITSPNWPD--KYPSRKECTWEIS--ATPGHRIKLA 815
Query: 2617 FEDFYLESHQDCQFDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERV 2675
F +F +E HQ+C +D LE G+ + P++ RLCG P PLV +++++ FV++ V
Sbjct: 816 FSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPD-PLVATGNKMFVRFVSDASV 874
Query: 2676 EHIGFHAKYSFTDCGG--------------IQIGDSGVITSPNYPNAYDSLTHCSSLLEA 2721
+ GF A +S T+CGG Q GD+ NYP D C LL +
Sbjct: 875 QRKGFQATHS-TECGGRLKAESKPRDLYSHAQFGDN------NYPGQVD----CEWLLVS 923
Query: 2722 PQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVV 2781
+G + L+F F++E C +D V + +G + +G++CG+ P I S + +++
Sbjct: 924 ERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
Query: 2782 TFNSDHSLQGGGFYATWNT 2800
F++D ++ GF+ + +
Sbjct: 984 HFHTDDTINKKGFHIRYKS 1002
Score = 259 bits (663), Expect = 3e-68
Identities = 175/677 (25%), Positives = 292/677 (43%), Gaps = 103/677 (15%)
Query: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
YR +CG S+G ++SP + YP+ HC++ ++V+ + I L F+ D+ S+ C
Sbjct: 344 YRCPACGETLQESNGNLSSPGFPNG-YPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLC 402
Query: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+DY+ + DG PLLG+FCG K P + S+++ M + F++ S KG+ +
Sbjct: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI- 461
Query: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
CGG + + SP+ + Y CVW I + + LTF +F +E
Sbjct: 462 -----CGGEIRKNEGQIQSPNYPDD--YRPMKECVWKITVSESYHVGLTFQSFEIER--- 511
Query: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YDY+++ DG SEN+ L G FCG P S+ N L ++F+SD T+ + GF A +
Sbjct: 512 HDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
Query: 3272 TIMDMPCG---------------GTYNATWTPQ-----------------------NISS 3293
+ C G+Y P I++
Sbjct: 572 FKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITT 631
Query: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
P P C W + +P ++ + +L + C +Y+++ +
Sbjct: 632 PGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGK 691
Query: 3353 FCGRNASAVPVFYSSMSTAMVIFKS-GVVNR--------------------------NSR 3385
FCG A V S + + FKS V++ N+
Sbjct: 692 FCG--AEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTM 749
Query: 3386 MSFTYQI---------------ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQN 3430
S+ Q A+C + H G + SP WPD Y + K+CT ++A
Sbjct: 750 GSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG 809
Query: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490
H I L F IE EC D LEV +G SP+LG+ CG +P+P+ + N++++RF
Sbjct: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869
Query: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGD---RGSFTSPGY-PGTYPNNTYCEWVLVAPAG 3546
SD+ +G++ + + CGG L + R ++ + YP CEW+LV+ G
Sbjct: 870 SDASVQRKGFQ---ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERG 926
Query: 3547 RLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKF 3606
+ ++F +++ DC +Y+ L+DG ++++ G +CG + + V I F
Sbjct: 927 SRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPP-EEIYSIGDSVLIHF 985
Query: 3607 HADYARRPSAFRLTWDS 3623
H D F + + S
Sbjct: 986 HTDDTINKKGFHIRYKS 1002
Score = 241 bits (615), Expect = 1e-62
Identities = 173/663 (26%), Positives = 290/663 (43%), Gaps = 104/663 (15%)
Query: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Y CG + +G + S G P Y C W + G + ++F +L SS C
Sbjct: 344 YRCPACGETLQESNGNLSSPGFPN-GYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLC 402
Query: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
D++E+ D + +LGR+CG+ +P+ + ++ + + F + + GF +E+
Sbjct: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI- 461
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
CGG+++ + G SPNYP+ + C W+IT E + L F + + H +C ++
Sbjct: 462 --CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
Query: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
+ V +G NSP + + C + +I+S+ NT+ + F +DG+ GF A++ ED
Sbjct: 520 LEVRDGTSENSPLIGRFC-GYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
Query: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
A CGG L G T+PG+
Sbjct: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKL-NGTITTPGWP-- 635
Query: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
+ Y N NC W + P Q IS+ FE F LE ++ C++D +E G ++ L + C
Sbjct: 636 KEYPPNKNCVWQVVAPTQ--YRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
Query: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------SFTDCGGIQ---------- 2693
G P + + ++ + I F ++ V GF A + D GG Q
Sbjct: 694 GAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSY 752
Query: 2694 --------------------------IGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTI 2727
SG+ITSPN+P+ Y S C+ + A GH I
Sbjct: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
Query: 2728 TLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDH 2787
L FS+F+IE H CA+D + V +G + +SPI+G+ CGN P + + N++ V F SD
Sbjct: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
Query: 2788 SLQGGGFYATWNTQTLGCGGIFHSDNGT----IRSPHWPQNFPENSRCSWTAITHKSKHL 2843
S+Q GF AT +T+ CGG +++ + N+P C W ++ + L
Sbjct: 873 SVQRKGFQATHSTE---CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
Query: 2844 EISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQ 2903
E+SF + D C +V+++ G + L CG+ P + + ++ F
Sbjct: 930 ELSFQTFEVEEEAD--CGYDYVELFDGLDSTAVG-LGRFCGSGPPEEIYSIGDSVLIHFH 986
Query: 2904 SQE 2906
+ +
Sbjct: 987 TDD 989
Score = 240 bits (612), Expect = 2e-62
Identities = 175/683 (25%), Positives = 288/683 (42%), Gaps = 109/683 (15%)
Query: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743
Y CG +G ++SP +PN Y S THC + G I L F+ D+ + C
Sbjct: 344 YRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
Query: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803
+D + VR+G +SP++G++CG+ P + S +++ + F S + G GF A +
Sbjct: 404 YDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-- 461
Query: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863
CGG + G I+SP++P ++ C W +S H+ ++F + F I D C
Sbjct: 462 -CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN-CAYD 518
Query: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASFVSR--- 2919
+++V GT E + L+ CG P + + SNT F S + GF+A+F
Sbjct: 519 YLEVRDGTSE-NSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
Query: 2920 ----------------------------------------CGSNFTGPSGYIISPNYPKQ 2939
CG T +G I +P +PK+
Sbjct: 578 CAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKE 637
Query: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999
Y N NC + + A + + F F LE C D V I G S S C
Sbjct: 638 YPPNKNCVWQVVAPTQYRISVKFEFFELEGNEV----CKYDYVEIWSGLSSESKLHGKFC 693
Query: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFKFSY-------------------------- 3032
G E+P +T + + F S+ ++ GFK +
Sbjct: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYM 753
Query: 3033 ----------------RIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVI 3076
+ C + SG+ITSP + YP+ C + I+ + I
Sbjct: 754 CQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWP-DKYPSRKECTWEISATPGHRI 812
Query: 3077 ELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDS 3136
+L FS+F++ C++D+L ++DG P+LG+ CG+K P + ++ N M + F +D+
Sbjct: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
Query: 3137 FQTAKGWKMSFRQTLGPQQGCGGYLTGSNNT--FASPDSDSNGMYDKNLNCVWIIIAPVN 3194
KG++ + CGG L + S + Y ++C W++++
Sbjct: 873 SVQRKGFQATHSTE------CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERG 926
Query: 3195 KVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTV 3254
+ L+F TF +E + C YDYV+L+DG A G FCGS P S G+ + +
Sbjct: 927 SRLELSFQTFEVEEEAD---CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
Query: 3255 QFISDLTLEREGFNATYTIMDMP 3277
F +D T+ ++GF+ Y + P
Sbjct: 984 HFHTDDTINKKGFHIRYKSIRYP 1006
Score = 206 bits (523), Expect = 4e-52
Identities = 155/633 (24%), Positives = 266/633 (42%), Gaps = 96/633 (15%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
CG NG + SP +P +P + C W + + ++F L S C +
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSS--LCWYDY 406
Query: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923
++V G LL CG+ P + + + F+S +GF+A + + CG
Sbjct: 407 IEVRDGYWR-KSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGE 465
Query: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
G I SPNYP Y C + I + V LTF SF +E +C D +
Sbjct: 466 IRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----NCAYDYLE 521
Query: 2984 IIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSY---------- 3032
+ G S S CG + P + L + F S+ + GF ++
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 3033 -------RIIS-------------------------CGGVFNFSSGIITSPAYSYADYPN 3060
R ++ CGG+ +G IT+P + +YP
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWP-KEYPP 640
Query: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
+ +C++ + I +KF F++ + C +DY+ I+ G ++ L GKFCG++ P
Sbjct: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEV 700
Query: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSF--------RQTLGPQQGC----GGYLTGSNNTF 3168
+ S N+M + FK+D+ + KG+K F + G Q C G Y+ N F
Sbjct: 701 ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGF 760
Query: 3169 ASPDSDSN-----------------------GMYDKNLNCVWIIIAPVNKVIHLTFNTFA 3205
D+ + Y C W I A I L F+ F
Sbjct: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
Query: 3206 LEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLERE 3265
+E Q C YD+++++DG++E + + G CG+ +P P +++GN + V+F+SD +++R+
Sbjct: 821 IEQ---HQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRK 877
Query: 3266 GFNATYTIMDMPCGGTYNATWTPQNI-SSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVW 3323
GF AT++ CGG A P+++ S D + P + C W++ S +++++
Sbjct: 878 GFQATHS---TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
Query: 3324 ALQLTSQ-DCTQNYLQLQDSPQGHGNSRFQFCG 3355
++ + DC +Y++L D +FCG
Sbjct: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCG 967
Score = 124 bits (312), Expect = 1e-27
Identities = 117/461 (25%), Positives = 186/461 (40%), Gaps = 82/461 (17%)
Query: 295 GWQGNGYICEDINEC-EINNGGCSVAPPVECVNTPGSSHCQACPPGYQ--GDGRVCTLTD 351
G+ N + ED EC + + GGC C+NT GS C AC PGY+ D R C
Sbjct: 566 GFAANFFKEED--ECAKPDRGGCEQ----RCLNTLGSYQC-ACEPGYELGPDRRSC---- 614
Query: 352 ICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN-GCV-QLSNICLSHPCLNGQC 409
+A+C L L PG+ Y PN CV Q+ + +
Sbjct: 615 -----------EAACGGLLTKLNGTITTPGWPKE-YPPNKNCVWQVVAPTQYRISVKFEF 662
Query: 410 IDTVSGYFCKCD--SGWTGVN---------CTENINECLSNP------------------ 440
+ CK D W+G++ C + E +++
Sbjct: 663 FELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKG 722
Query: 441 -----------CL--NGGT---CVDGVDSFSCECTRLWT--GALCQVPQQVCGESLSGIN 482
C NGG CV+ + S+ C+C + + C + + +
Sbjct: 723 FKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPS 782
Query: 483 GSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSA 542
G + + Y C W I G +++ F+ F +E C ++ L+V+DG++ +
Sbjct: 783 GLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS 842
Query: 543 FQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGIL---TGPYG 599
LGR CG+ +P L+++ N ++ S+ +GF T ECGG L + P
Sbjct: 843 PILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQA---THSTECGGRLKAESKPRD 899
Query: 600 SIKSPGY-PGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQD 658
+ NYP DC W++V+ + +F T +E DC DY+E+ DG
Sbjct: 900 LYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTA 959
Query: 659 PLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITY 699
LG+FC + + + G IHFH+D I+ +GFHI Y
Sbjct: 960 VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
Score = 33.5 bits (75), Expect = 3.9
Identities = 28/102 (27%), Positives = 40/102 (39%), Gaps = 27/102 (26%)
Query: 169 ADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG 228
+D +EC +G CQ+ CVNTMGSY C C G DC+ + +H
Sbjct: 729 SDKDECSKDNG---GCQH--ECVNTMGSYMCQC---RNGFVLHDNKHDCKEAECEQKIHS 780
Query: 229 ICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQ 270
+G + SPN P R EC+++
Sbjct: 781 -------------------PSGLITSPNWPDKYPSRKECTWE 803
Score = 33.5 bits (75), Expect = 3.9
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 6/50 (12%)
Query: 263 DRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECE 310
D+DECS G C +C NT GS+ C C G+ N + C++ ECE
Sbjct: 730 DKDECSKDNGGCQH--ECVNTMGSYMC-QCRNGFVLHDNKHDCKEA-ECE 775
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 317 bits (812), Expect = 1e-85
Identities = 196/683 (28%), Positives = 326/683 (47%), Gaps = 115/683 (16%)
Query: 1033 EGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTN 1092
+G + + AC + D G F++P FPN YP+ C++RI+V G+ I ++FT+
Sbjct: 336 QGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTS 395
Query: 1093 FSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRS 1152
L ++ +Y D++E+RDG + K+PLLG F G +P ++S ++LW++F+S
Sbjct: 396 MDLFKSRLCWY-DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGK 454
Query: 1153 GFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHL 1212
GF A ++ + CGG++ +G SPNYP Y S EC W + S G L F+ F +
Sbjct: 455 GFFAAYEAT---CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEI 511
Query: 1213 EHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKA 1272
E H +C DYL V DGP+ S L+ CG EKP ++SS + +++K +D GF A
Sbjct: 512 ERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAA 571
Query: 1273 EY---------------RQTCENVV--------------------------IVNQTYGIL 1291
+ C N + + + G +
Sbjct: 572 NFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTI 631
Query: 1292 ESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQM 1347
S G+P Y N++C W + A ++ F F+LE + C D++E+ G +
Sbjct: 632 TSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLH 691
Query: 1348 GRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWF-------------------- 1387
GR+CG + P ++ S+ ++V +D + +GF+ +F
Sbjct: 692 GRFCGSETPEVITSQSNNMRVEFKSDNTVSK-RGFRAHFFSDKDECAKDNGGCQHECVNT 750
Query: 1388 ----------------------VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDP 1425
GC ++S G+ +SP +P++YP +EC W I +
Sbjct: 751 FGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTA 810
Query: 1426 GSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELA 1485
G ++LT ++F++E H C +D LE+Y GPD +P + + C + P+ + ++G+ +
Sbjct: 811 GHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTV---ASGSSMF 867
Query: 1486 IRFKTDLSINGRGFNASWQAVTGGCGGIFQA--PSGEIHS------PNYPSPYRSNTDCS 1537
+RF +D S+ +GF A + CGG +A + E++S NYPS R C
Sbjct: 868 LRFYSDASVQRKGFQA---VHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEAR----CD 920
Query: 1538 WVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSS 1593
WVI + + V L F F++E + C + AYDG S+ RL R CG L I S+
Sbjct: 921 WVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPL-EEIYSA 979
Query: 1594 GNSLFLRFQSGPSRQNRGFRAQF 1616
G+SL +RF++ + +GF A++
Sbjct: 980 GDSLMIRFRTDDTINKKGFHARY 1002
Score = 315 bits (808), Expect = 4e-85
Identities = 208/664 (31%), Positives = 305/664 (45%), Gaps = 102/664 (15%)
Query: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
ACGE L ++TG +PG PN YP +C W I V P I L F + L C DY+
Sbjct: 350 ACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYV 409
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
EV D + LGR+CG IP L S+ + L + F + S++ +GF YEA C
Sbjct: 410 EVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA-----TC 464
Query: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
D D G SPN+P++Y + EC++RITV G + + F F +E Y D+LE
Sbjct: 465 GGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAY-DYLE 523
Query: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA---------YWD 1159
+RDG E+S L+G F G P + S SN+LW+KF SD ++GF+A W
Sbjct: 524 VRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188
GS CGG +T +GT SP +P Y +
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN 643
Query: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
C W + + L+F+ F LE + C D++ V G S ++ L + CG E P +I
Sbjct: 644 KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVI 703
Query: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEY--------------RQTCENVV------------ 1282
S ++M ++ ++D RGF+A + + C N
Sbjct: 704 TSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYW 763
Query: 1283 ---------------IVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDL 1327
++ G L S +P+ Y + C W I +T G+ V TF F++
Sbjct: 764 LHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEI 823
Query: 1328 EHHINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQ 1383
E H C+ D+LE+YDGP +GR+CG P P + S + + +D +R KGFQ
Sbjct: 824 EQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQR-KGFQ 882
Query: 1384 MQWFVYGCGGELSGATGS---FSSPGF-PNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
CGG L + +S F N YP C W I + G ++LT F+VE
Sbjct: 883 AVHST-ECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVE 941
Query: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
+ C +D +E Y G D +PR+ + C E ++ S G+ L IRF+TD +IN +GF
Sbjct: 942 EEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLE---EIYSAGDSLMIRFRTDDTINKKGF 998
Query: 1500 NASW 1503
+A +
Sbjct: 999 HARY 1002
Score = 307 bits (787), Expect = 1e-82
Identities = 209/687 (30%), Positives = 314/687 (45%), Gaps = 100/687 (14%)
Query: 1607 RQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHIT 1661
R ++G AQ R+ ACG L + S+P FP YP+ +C W I P I
Sbjct: 333 RLSQGDIAQARKLYKCPACG-ETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPG-EKIV 390
Query: 1662 LSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSS 1721
L+FT +L +S C D+VE+ DG APL GR+CG +P P+ S S L + F S S+
Sbjct: 391 LNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSN 450
Query: 1722 ISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFI 1781
I GF A+ CGG G SP YPD Y P+ ECVW I S G + L+F
Sbjct: 451 ILGKGFFAAYEAT---CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQ 507
Query: 1782 SFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSG 1840
+F++E C+ D++E+R+G L+G +CG P + S + LW++F+SDGS +
Sbjct: 508 AFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKS-SSNRLWMKFVSDGSINK 566
Query: 1841 TGFQATFMK------------------------------------------IFGNDNIVG 1858
GF A F K + I
Sbjct: 567 AGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITK 626
Query: 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSI 1918
+G + SP WP+ YP N N W V A + + + ++E C YD + + G S
Sbjct: 627 LNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSP 686
Query: 1919 HARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA----VDAPDGVLPTI 1973
A+L G +CG++T E +S N++ F SD+++S +GF +F+ +G
Sbjct: 687 DAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHE 746
Query: 1974 APGACGGFL-----------------------RTGDAPVFLFSPGWPDSYSNRVDCTWLI 2010
G +L + L SP WPD Y +R +CTW I
Sbjct: 747 CVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNI 806
Query: 2011 QA-PDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYM 2069
+ V+L +IE H+ CAYD L + DG ++LA L CG + P P ++G M
Sbjct: 807 SSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSM 866
Query: 2070 FIRFTSDSSVTRAGFNASFHKSCGGYLHADRGIITSPKY------PETYPSNLNCSWHVL 2123
F+RF SD+SV R GF A CGG L A+ + T Y YPS C W ++
Sbjct: 867 FLRFYSDASVQRKGFQAVHSTECGGRLKAE--VQTKELYSHAQFGDNNYPSEARCDWVIV 924
Query: 2124 VQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASST 2183
+ G + + F + F++ ++ C DY+ +G D +P L G FCGS
Sbjct: 925 AEDGYGVELTF-RTFEVEE-EADCGY-DYMEAYDGYDSSAPRL------GRFCGSGPLEE 975
Query: 2184 LFTSDNQMFVQFISDHSNEGQGFKIKY 2210
++++ + + ++F +D + +GF +Y
Sbjct: 976 IYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 300 bits (769), Expect = 1e-80
Identities = 190/663 (28%), Positives = 296/663 (44%), Gaps = 101/663 (15%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CG L ++G F +P +P Y S C W + + G L F L C DY+
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
V DG + LL + CGD+ P + S+ ++++ R+ G+GF A Y TC +
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDM-- 468
Query: 1285 NQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP 1344
N+ G ++S YP+ Y ++ C W I + G V TF AF++E H +C+ DYLE+ DGP
Sbjct: 469 NKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGP 528
Query: 1345 RQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFV------------ 1388
+ +G +CG + P ++S++L + ++DG + GF +F
Sbjct: 529 TEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDG-SINKAGFAANFFKEVDECSWPDHGG 587
Query: 1389 ------------------------------YGCGGELSGATGSFSSPGFPNRYPPNKECI 1418
CGG ++ G+ +SPG+P YP NK C+
Sbjct: 588 CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCV 647
Query: 1419 WYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVS 1478
W + I L F++E + C +D +E+ G + + C +PE ++
Sbjct: 648 WQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPE---VIT 704
Query: 1479 STGNELAIRFKTDLSINGRGF----------------------------------NASWQ 1504
S N + + FK+D +++ RGF N W
Sbjct: 705 SQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWL 764
Query: 1505 AVTG------GCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE 1558
G GC + G + SPN+P Y S +C+W I HRV L F +F++E
Sbjct: 765 HENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIE 824
Query: 1559 PQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRA 1614
C + YDG S L R CG ++ +P V+SG+S+FLRF S S Q +GF+A
Sbjct: 825 QHQECAYDHLEMYDGPDSLAPILGRFCGSKK-PDPTVASGSSMFLRFYSDASVQRKGFQA 883
Query: 1615 QFRQACGGHILTS--SFDTVSSPRF-PANYPNNQNCSWIIQAQPPLNHITLSFTHFELER 1671
CGG + + + S +F NYP+ C W+I A+ + L+F FE+E
Sbjct: 884 VHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYG-VELTFRTFEVEE 942
Query: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV 1731
C D++E DG AP GR+CG+ I S +L +RF +D +I+ GFH
Sbjct: 943 EADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Query: 1732 TAS 1734
T++
Sbjct: 1003 TST 1005
Score = 298 bits (763), Expect = 7e-80
Identities = 197/670 (29%), Positives = 297/670 (44%), Gaps = 109/670 (16%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
CG Q +G +P +P+ Y S + C W I V +++LNFT DL C Y
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
DG L R CG +++ P+VS+ + L++ F+S + +GF A + CGG +
Sbjct: 411 VRDGYWRKAPLLGRFCG-DKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGD-M 468
Query: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
+ SP +P +Y ++ C W I H+ L+F FE+ER +CA D++E+ DG
Sbjct: 469 NKDAGQIQSPNYPDDYRPSKECVWRITVSEGF-HVGLTFQAFEIERHDSCAYDYLEVRDG 527
Query: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVS--------- 1736
E++ L G +CG + P + S S+ L ++FVSD SI+ GF V
Sbjct: 528 PTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGG 587
Query: 1737 -------------------------------ACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
ACGG G SPG+P YP N CV
Sbjct: 588 CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCV 647
Query: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
W +V+ R+ L F F+LE + C DFVE+R G + L GR+CG+ P +S
Sbjct: 648 WQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITS-Q 706
Query: 1825 GHTLWVRFISDGSGSGTGFQATF------------------MKIFGN------------- 1853
+ + V F SD + S GF+A F + FG+
Sbjct: 707 SNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHE 766
Query: 1854 -----------DNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEI 1902
I G +ASP WP+ YP W ++ A H V E +IE+
Sbjct: 767 NGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQH 826
Query: 1903 QNCYYDKLRIYDGPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWF 1961
Q C YD L +YDGP A ++G +CG+ + + ++G+S+ FYSD+S+ KGF
Sbjct: 827 QECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGF----- 881
Query: 1962 AVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPG--WPDSYSNRVDCTWLIQAPDS-TVE 2018
+ CGG L+ L+S ++Y + C W+I A D VE
Sbjct: 882 ---------QAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVE 932
Query: 2019 LNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSS 2078
L + ++E C YD + DG ++ A +L CG I S G+ + IRF +D +
Sbjct: 933 LTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDT 992
Query: 2079 VTRAGFNASF 2088
+ + GF+A +
Sbjct: 993 INKKGFHARY 1002
Score = 296 bits (758), Expect = 2e-79
Identities = 204/670 (30%), Positives = 292/670 (43%), Gaps = 97/670 (14%)
Query: 807 ASFRAVYQV-ACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
A R +Y+ ACG+ L G +P FPN YP C W I + I+LNFT ++
Sbjct: 340 AQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLF 399
Query: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
S C DYVE+ +P ++CG IP + S + L+V F SS+ GF
Sbjct: 400 KSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGF--- 456
Query: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
F+A + CG + + G IQSP +P+ Y C W I V + L F+ F +E H +
Sbjct: 457 FAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDS 516
Query: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
C DYLEV D +E S +G +CG P + SS N L + FV+D + GF N+
Sbjct: 517 CAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKE 576
Query: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
+ AC T GT TSP +
Sbjct: 577 VDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGW 636
Query: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLE-EAIGNYYTDFLEIRDGGYEKSPLLGIF 1123
P YP N C++++ I++ F F LE + Y DF+E+R G + L G F
Sbjct: 637 PKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKY--DFVEVRSGLSPDAKLHGRF 694
Query: 1124 YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA--------------------------- 1156
GS P I S SN + ++FKSD ++ GF A
Sbjct: 695 CGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSY 754
Query: 1157 -------YW------DGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAF 1203
YW D GC +++ GT SPN+P Y EC W + S+ G
Sbjct: 755 LCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRV 814
Query: 1204 ELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDE 1263
+L F +F +E H C D+L +YDGP S + +L + CG +KP +SG SMF++ +D
Sbjct: 815 KLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDA 874
Query: 1264 GQQGRGFKAEYRQTCENVVIVN-QTYGILESIGY-PNPYSENQHCNWTIRATTGNTVNYT 1321
Q +GF+A + C + QT + + N Y C+W I A G V T
Sbjct: 875 SVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELT 934
Query: 1322 FLAFDLEHHINCSTDYLELYDG-----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVG 1376
F F++E +C DY+E YDG PR +GR+CG + L + TD
Sbjct: 935 FRTFEVEEEADCGYDYMEAYDGYDSSAPR-LGRFCGSGPLEEIYSAGDSLMIRFRTDDT- 992
Query: 1377 RREKGFQMQW 1386
+KGF ++
Sbjct: 993 INKKGFHARY 1002
Score = 285 bits (730), Expect = 4e-76
Identities = 195/681 (28%), Positives = 312/681 (45%), Gaps = 114/681 (16%)
Query: 1854 DNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIY 1913
+ + T G ++P +P YP S+ W ++V + MD+ + + C+YD + +
Sbjct: 353 ETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVR 412
Query: 1914 DGPSIHARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPT 1972
DG A L+G +CG + E ST + L F S S+I GKGF + A
Sbjct: 413 DGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT--------- 463
Query: 1973 IAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRT 2031
CGG + + SP +PD Y +C W I + V L + +IE H +
Sbjct: 464 -----CGGDMNKDAGQIQ--SPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDS 516
Query: 2032 CAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK- 2090
CAYD L +RDG + + CG E P ++S+ ++++F SD S+ +AGF A+F K
Sbjct: 517 CAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKE 576
Query: 2091 ------------------------------------------SCGGYLHADRGIITSPKY 2108
+CGG++ G ITSP +
Sbjct: 577 VDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGW 636
Query: 2109 PETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGP 2168
P+ YP+N NC W V+ + I++ FE F++ G+ C D++ +R+G L P
Sbjct: 637 PKEYPTNKNCVWQVVAPAQYRISLQFEV-FEL-EGNDVCKY-DFVEVRSG-------LSP 686
Query: 2169 PGG-NGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLAC----GG---- 2219
+G FCGS + + N M V+F SD++ +GF+ + + C GG
Sbjct: 687 DAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHE 746
Query: 2220 -------------NVYI-----HDADSAGY----------VTSPNHPHNYPPHADCIWIL 2251
N Y HD AG + SPN P YP +C W +
Sbjct: 747 CVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNI 806
Query: 2252 AAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEV 2311
++ R++L F + F+IE C ++LE+ DG DS APIL +FCG+ P +SG
Sbjct: 807 SSTAGHRVKLTFNE-FEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSS 865
Query: 2312 MYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTL---PYRDNLFCEWHLQ 2368
M+LRF SD S GF+A +S +CGGR+ + E H Y C+W +
Sbjct: 866 MFLRFYSDASVQRKGFQAVHS-TECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIV 924
Query: 2369 GLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAV 2427
G+ + ++F F ++ + C D++E +D + +S LGR+CG+ + I ++ ++ +
Sbjct: 925 AEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLM 984
Query: 2428 VRFVTDGSVTASGFRLRFESS 2448
+RF TD ++ GF R+ S+
Sbjct: 985 IRFRTDDTINKKGFHARYTST 1005
Score = 283 bits (723), Expect = 3e-75
Identities = 192/682 (28%), Positives = 305/682 (44%), Gaps = 117/682 (17%)
Query: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
ACG L+ D +PG+P+ Y + C W I P + LN S+D+ R C YD
Sbjct: 350 ACGETLQ--DTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD 407
Query: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
+ +RDG A L CG +IP P+ ST +++ F S S++ GF A++ +CGG
Sbjct: 408 YVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGD 467
Query: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
++ D G I SP YP+ Y + C W + V G + + F Q F+I DS DYL +
Sbjct: 468 MNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTF-QAFEIERHDSCAY--DYLEV 524
Query: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAK-- 2213
R+GP S +G HFCG + +S N+++++F+SD S GF + +
Sbjct: 525 RDGPTEESALIG------HFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVD 578
Query: 2214 --------------------------------------SLACGGNVYIHDADSAGYVTSP 2235
+ACGG + G +TSP
Sbjct: 579 ECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFI----TKLNGTITSP 634
Query: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
P YP + +C+W + AP + RI LQFE F++E C +++E+R G+ DA + +
Sbjct: 635 GWPKEYPTNKNCVWQVVAPAQYRISLQFEV-FELEGNDVCKYDFVEVRSGLSPDAKLHGR 693
Query: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY------------------------ 2331
FCG+ P S M + F+SDN+ + GF+A +
Sbjct: 694 FCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGS 753
Query: 2332 ------------------SIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGH 2373
A C ++ G + S P Y C W++ +GH
Sbjct: 754 YLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPD-KYPSRRECTWNISSTAGH 812
Query: 2374 YLTISFEDFNLQNSSGCEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVT 2432
+ ++F +F ++ C D +E++D S ILGR+CG+ PD S ++ +RF +
Sbjct: 813 RVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYS 872
Query: 2433 DGSVTASGFRLRFESSMEECGGDLQGSIGT--------FTSPNYPNPNPHGRICEWRITA 2484
D SV GF+ + ECGG L+ + T F NYP+ C+W I A
Sbjct: 873 DASVQRKGFQAVHST---ECGGRLKAEVQTKELYSHAQFGDNNYPSEAR----CDWVIVA 925
Query: 2485 PEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMK 2544
+G + L F + C +++ ++G S++P+L + C S + EI S+G+++
Sbjct: 926 EDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLE-EIYSAGDSLM 984
Query: 2545 VIFFTDGSRPYGGFTASYTSSE 2566
+ F TD + GF A YTS++
Sbjct: 985 IRFRTDDTINKKGFHARYTSTK 1006
Score = 275 bits (703), Expect = 6e-73
Identities = 195/721 (27%), Positives = 301/721 (41%), Gaps = 108/721 (14%)
Query: 533 QVYDGDS-----SSAFQLGRFCGSSLPHELLSSDNALYFHLYSE-HLRNGRGFTVRWETQ 586
+ YD DS + F G F + LP + DN + + L G R +
Sbjct: 291 ETYDFDSIMHYARNTFSRGVFLDTILPRQ---DDNGVRPTIGQRVRLSQGDIAQARKLYK 347
Query: 587 QPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKD 646
P CG L G+ +PG+P YP CVW + +P + F ++ L C D
Sbjct: 348 CPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD 407
Query: 647 YLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDL 706
Y+E+RDG + PLLG+FC PL +T + F S S I +GF Y +
Sbjct: 408 YVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY-----EA 462
Query: 707 RCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYI 766
CGG+ G++ P + +++CV+ + +G + + F E++ + +Y+
Sbjct: 463 TCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYL 522
Query: 767 EVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY--------- 813
EVRDG T L+G CG +KS +N +W++F D S+ KA F A +
Sbjct: 523 EVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSW 582
Query: 814 ----------------------------------QVACGDELTG-EGVIRSPFFPNVYPG 838
+VACG +T G I SP +P YP
Sbjct: 583 PDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPT 642
Query: 839 ERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSF 898
+ C W + P I L F VFE+ + C+ D+VE+ S + + ++CG++ P
Sbjct: 643 NKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEV 702
Query: 899 ITSVYNFLYVTFVKSSSTENHGFMAKF--------------------------------- 925
ITS N + V F ++ GF A F
Sbjct: 703 ITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGY 762
Query: 926 -------SAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFH 978
++ C ++ GT+ SP P+ YP CTW+I H + L F F
Sbjct: 763 WLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFE 822
Query: 979 LEFHYNCTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFL 1036
+E H C D+LE+YD + LGR+CG P +SG+S+ L F +D+ + +GF
Sbjct: 823 IEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882
Query: 1037 INYEAISAATACLQDYTDDLGTFTSPNF-PNNYPNNWECIYRITVRTGQLIAVHFTNFSL 1095
+ + T +L ++ F NNYP+ C + I G + + F F +
Sbjct: 883 AVHSTECGGRLKAEVQTKEL--YSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEV 940
Query: 1096 EEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFS 1155
EE Y D++E DG +P LG F GS I S + L ++F++D + GF
Sbjct: 941 EEEADCGY-DYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFH 999
Query: 1156 A 1156
A
Sbjct: 1000 A 1000
Score = 274 bits (701), Expect = 1e-72
Identities = 187/663 (28%), Positives = 281/663 (42%), Gaps = 101/663 (15%)
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CG D G P + CV+ + GE+I +NFT ++L +Y+E
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 768 VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823
VRDG LLG+ CG+ + S + +W+ F+ +++ F A Y+ CG ++
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNK 470
Query: 824 E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882
+ G I+SP +P+ Y + C W I + + L F FEI C DY+E+
Sbjct: 471 DAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTE 530
Query: 883 GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928
S +CG + P + S N L++ FV S GF A F E
Sbjct: 531 ESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEH 590
Query: 929 --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962
++ACG +T+ GTI SPG P YP NC W +
Sbjct: 591 RCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQV 650
Query: 963 LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSL--GRYCGKSIPPSLTSSGNSL 1020
+ + I L FE F LE + C D++EV S + GR+CG P +TS N++
Sbjct: 651 VAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNM 710
Query: 1021 MLVFVTDSDLAYEGFLINY----------------EAISA-------------------- 1044
+ F +D+ ++ GF ++ E ++
Sbjct: 711 RVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHD 770
Query: 1045 --ATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNY 1102
C + GT SPN+P+ YP+ EC + I+ G + + F F +E+
Sbjct: 771 CKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECA 830
Query: 1103 YTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSS 1162
Y D LE+ DG +P+LG F GS P ++ + ++L+F SD R GF A S
Sbjct: 831 Y-DHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAV---HS 886
Query: 1163 TGCGGNLTT--------SSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEH 1214
T CGG L S F NYP + C W + + G EL F+ F +E
Sbjct: 887 TECGGRLKAEVQTKELYSHAQFGDNNYPS----EARCDWVIVAEDGYGVELTFRTFEVEE 942
Query: 1215 HPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
+C DY+ YDG S++ L + CG I S+GDS+ I+ RTD+ +GF A Y
Sbjct: 943 EADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Query: 1275 RQT 1277
T
Sbjct: 1003 TST 1005
Score = 269 bits (688), Expect = 3e-71
Identities = 196/674 (29%), Positives = 295/674 (43%), Gaps = 112/674 (16%)
Query: 2570 CGGSLPNTPEGNFTSPGY-DGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQD 2627
CG +L +T GNF++PG+ +G +YS +C W +S P + I ++F L +
Sbjct: 351 CGETLQDTT-GNFSAPGFPNGYPSYS---HCVWRISVTPGE---KIVLNFTSMDLFKSRL 403
Query: 2628 CQFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSF 2686
C +D +E R G PL+ R CG P PLV S++W+ F ++ + GF A Y
Sbjct: 404 CWYDYVEVRDGYWRKAPLLGRFCGDKIPE-PLVSTDSRLWVEFRSSSNILGKGFFAAYEA 462
Query: 2687 TDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDS 2746
T CGG D+G I SPNYP+ Y C + +G + LTF F+IE H +CA+D
Sbjct: 463 T-CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDY 521
Query: 2747 VTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYA---------T 2797
+ VR+G + ES +IG +CG P ++S SN+L + F SD S+ GF A +
Sbjct: 522 LEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECS 581
Query: 2798 WN---------TQTLG----------------------CGGIFHSDNGTIRSPHWPQNFP 2826
W TLG CGG NGTI SP WP+ +P
Sbjct: 582 WPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYP 641
Query: 2827 ENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNV 2886
N C W + + + F+ L G+ C+ FV+V +G D L CG+
Sbjct: 642 TNKNCVWQVVAPAQYRISLQFEVFEL--EGNDVCKYDFVEVRSGLSP-DAKLHGRFCGSE 698
Query: 2887 APGPVITPSNTFTAVFQSQEAPA-QGFSASFVS--------------------------- 2918
P + + SN F+S + +GF A F S
Sbjct: 699 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRC 758
Query: 2919 ----------------RCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTF 2962
C + G + SPN+P +Y + CT+ I + V LTF
Sbjct: 759 RNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTF 818
Query: 2963 VSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNE 3021
F +E C D + + G ++ CG + P P +G + L FYS+
Sbjct: 819 NEFEIEQHQ----ECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDA 874
Query: 3022 QITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYA-----DYPNDMHCLYTITVSDDKVI 3076
+ GF+ + CGG + + T YS+A +YP++ C + I D +
Sbjct: 875 SVQRKGFQ-AVHSTECGG--RLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGV 931
Query: 3077 ELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDS 3136
EL F F+V C +DY+ YDG ++S P LG+FCGS + S+ +S+++ F+TD
Sbjct: 932 ELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDD 991
Query: 3137 FQTAKGWKMSFRQT 3150
KG+ + T
Sbjct: 992 TINKKGFHARYTST 1005
Score = 265 bits (677), Expect = 6e-70
Identities = 177/672 (26%), Positives = 299/672 (44%), Gaps = 98/672 (14%)
Query: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272
K ACG + D+ G ++P P+ YP ++ C+W ++ P +I L F D+ +
Sbjct: 347 KCPACGETLQ----DTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTS-MDLFKS 401
Query: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332
C +Y+E+RDG AP+L +FCG +P S+ +++ FRS ++ GF A Y
Sbjct: 402 RLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE 461
Query: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392
A CGG + +G ++S +P YR + C W + G ++ ++F+ F ++ C
Sbjct: 462 -ATCGGDMNKDAGQIQSPNYPD-DYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAY 519
Query: 2393 DFVEIWDNHTSGN-ILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451
D++E+ D T + ++G +CG P+ + +SSN ++FV+DGS+ +GF F ++E
Sbjct: 520 DYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDE 579
Query: 2452 C----------------------------------------GGDLQGSIGTFTSPNYPNP 2471
C GG + GT TSP +P
Sbjct: 580 CSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKE 639
Query: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
P + C W++ AP RI+L F L + C + V V +G+ ++ + C S
Sbjct: 640 YPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGS-E 698
Query: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAV------CGGSLPNT-------- 2577
I S N M+V F +D + GF A + S +D C NT
Sbjct: 699 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRC 758
Query: 2578 ------------------------PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSI 2613
EG SP + Y C W +S + +
Sbjct: 759 RNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPD--KYPSRRECTWNIS--STAGHRV 814
Query: 2614 SIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTN 2672
+ F +F +E HQ+C +D LE G D+ P++ R CG KP P V S +++ F ++
Sbjct: 815 KLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPD-PTVASGSSMFLRFYSD 873
Query: 2673 ERVEHIGFHAKYSFTDCGG---IQIGDSGVITSPNY-PNAYDSLTHCSSLLEAPQGHTIT 2728
V+ GF A +S T+CGG ++ + + + N Y S C ++ A G+ +
Sbjct: 874 ASVQRKGFQAVHS-TECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVE 932
Query: 2729 LTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHS 2788
LTF F++E C +D + +G +P +G++CG+ I S + L++ F +D +
Sbjct: 933 LTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDT 992
Query: 2789 LQGGGFYATWNT 2800
+ GF+A + +
Sbjct: 993 INKKGFHARYTS 1004
Score = 263 bits (673), Expect = 2e-69
Identities = 180/658 (27%), Positives = 273/658 (41%), Gaps = 98/658 (14%)
Query: 474 CGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQ 533
CGE+L G+FS GY +C W I G+ + + FT L C +++++
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 534 VYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGI 593
V DG A LGRFCG +P L+S+D+ L+ S G+GF +E CGG
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT---CGGD 467
Query: 594 LTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDG 653
+ G I+SP YP +Y P ++CVW + S V TF +E HD C DYLE+RDG
Sbjct: 468 MNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDG 527
Query: 654 PLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPS--------- 704
P + L+G FC ++++ + F SD I+ GF +
Sbjct: 528 PTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGG 587
Query: 705 -----------------------------DLRCGGNYTDPEGELFLPELSGPFTHTRQCV 735
++ CGG T G + P + + CV
Sbjct: 588 CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCV 647
Query: 736 YMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----ETLLGKVCGNGTISHIKSIT 791
+ + P +I + F EL+ +++EVR G L G+ CG+ T I S +
Sbjct: 648 WQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQS 707
Query: 792 NSVWIRFKIDASVEKASFRAVY-------------------------------------- 813
N++ + FK D +V K FRA +
Sbjct: 708 NNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHEN 767
Query: 814 -----QVACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSA 867
+ C +++ EG + SP +P+ YP R C W I + L F FEI
Sbjct: 768 GHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQ 827
Query: 868 HCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA 927
C D++E+ +P ++CG+ P + + +++ F +S + GF A S
Sbjct: 828 ECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST 887
Query: 928 EDLACGEILTESTGTIQSPGH----PNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHY 983
E CG L T + H N YP C W I+ + + + L F TF +E
Sbjct: 888 E---CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEA 944
Query: 984 NCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
+C DY+E YD S LGR+CG + S+G+SLM+ F TD + +GF Y
Sbjct: 945 DCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 257 bits (656), Expect = 2e-67
Identities = 185/682 (27%), Positives = 293/682 (42%), Gaps = 111/682 (16%)
Query: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
+CG L G ++P +P YPS +C W + V G I ++F + S
Sbjct: 350 ACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTS---MDLFKSRLCWY 406
Query: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
DY+ +R+G +P LG FCG L ++D++++V+F S + G+GF Y
Sbjct: 407 DYVEVRDGYWRKAPLLG------RFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY 460
Query: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270
EA CGG++ AG + SPN+P +Y P +C+W + + L F+ F+IE
Sbjct: 461 EA---TCGGDMN----KDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQ-AFEIE 512
Query: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330
+C +YLE+RDG ++ ++ FCG P SS ++++F SD S GF A
Sbjct: 513 RHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAAN 572
Query: 2331 ----------------------------------YSIA--------QCGGRVPGQSGVVE 2348
Y +A CGG + +G +
Sbjct: 573 FFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTIT 632
Query: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN-HTSGNIL 2407
S G P Y N C W + + + +++ FE F L+ + C+ DFVE+ +
Sbjct: 633 SPGWPK-EYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLH 691
Query: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGD------------ 2455
GR+CG+ P+ I + SN V F +D +V+ GFR F S +EC D
Sbjct: 692 GRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTF 751
Query: 2456 ----------------------------LQGSIGTFTSPNYPNPNPHGRICEWRITAPEG 2487
+ GT SPN+P+ P R C W I++ G
Sbjct: 752 GSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAG 811
Query: 2488 RRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIF 2547
R+ L FN + H C +H+ +++G S +P L + C S + +SG++M + F
Sbjct: 812 HRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTV-ASGSSMFLRF 870
Query: 2548 FTDGSRPYGGFTASYTSSEDAVCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 2606
++D S GF A +++ CGG L S G NY C+W +
Sbjct: 871 YSDASVQRKGFQAVHSTE----CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVI--V 924
Query: 2607 NQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLCGPSKPTLPLVIPYSQV 2665
+ + + F F +E DC +D +E G D+ P + R CG S P + +
Sbjct: 925 AEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCG-SGPLEEIYSAGDSL 983
Query: 2666 WIHFVTNERVEHIGFHAKYSFT 2687
I F T++ + GFHA+Y+ T
Sbjct: 984 MIRFRTDDTINKKGFHARYTST 1005
Score = 242 bits (618), Expect = 4e-63
Identities = 182/676 (26%), Positives = 282/676 (41%), Gaps = 109/676 (16%)
Query: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979
CG +G +P +P Y + +C + I P ++L F S L C
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRL----CWY 406
Query: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038
D V + GY + CGD++P PL L + F S+ I GF +Y +CG
Sbjct: 407 DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA-TCG 465
Query: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098
G N +G I SP Y DY C++ ITVS+ + L F F++ SC++DYL +
Sbjct: 466 GDMNKDAGQIQSPNYP-DDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEV 524
Query: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQ--------- 3149
DG L+G FCG ++P +VKSS+N + + F +D G+ +F +
Sbjct: 525 RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPD 584
Query: 3150 ----------TLGPQQ------------------GCGGYLTGSNNTFASPDSDSNGMYDK 3181
TLG + CGG++T N T SP Y
Sbjct: 585 HGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKE--YPT 642
Query: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241
N NCVW ++AP I L F F LE C YD+V++ G S +A L G FCGS
Sbjct: 643 NKNCVWQVVAPAQYRISLQFEVFELEGNDV---CKYDFVEVRSGLSPDAKLHGRFCGSET 699
Query: 3242 PAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCG--------------GTY----- 3282
P S N + V+F SD T+ + GF A + C G+Y
Sbjct: 700 PEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCR 759
Query: 3283 NATWTPQN-------------------ISSPNSSDPDVPFSICTWVIDSPPHQQVKITVW 3323
N W +N ++SPN D CTW I S +VK+T
Sbjct: 760 NGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFN 819
Query: 3324 ALQLTS-QDCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNR 3382
++ Q+C ++L++ D P +FCG + P S S + + V R
Sbjct: 820 EFEIEQHQECAYDHLEMYDGPDSLAPILGRFCG-SKKPDPTVASGSSMFLRFYSDASVQR 878
Query: 3383 NS-----------RMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNH 3431
R+ Q + H FG+ +NY ++ C + A +
Sbjct: 879 KGFQAVHSTECGGRLKAEVQTKELYS--HAQFGD-------NNYPSEARCDWVIVAEDGY 929
Query: 3432 TISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKS 3491
+ L F + +E +C D++E +G +S++P LG++CG+ ++S + L +RF++
Sbjct: 930 GVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRT 989
Query: 3492 DSVTSDRGYEIIWTSS 3507
D + +G+ +TS+
Sbjct: 990 DDTINKKGFHARYTST 1005
Score = 241 bits (616), Expect = 7e-63
Identities = 172/680 (25%), Positives = 294/680 (43%), Gaps = 109/680 (16%)
Query: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Y+ +CG ++G ++P + YP+ HC++ I+V+ + I L F+ D+ S C
Sbjct: 346 YKCPACGETLQDTTGNFSAPGFPNG-YPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404
Query: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+DY+ + DG PLLG+FCG K P + S+++ + + F++ S KG+ ++ T
Sbjct: 405 WYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT- 463
Query: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
CGG + SP+ + Y + CVW I + LTF F +E +
Sbjct: 464 -----CGGDMNKDAGQIQSPNYPDD--YRPSKECVWRITVSEGFHVGLTFQAFEIERHDS 516
Query: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YDY+++ DG +E + L G FCG P SS N L ++F+SD ++ + GF A +
Sbjct: 517 ---CAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573
Query: 3272 ----------------------------------------TIMDMPCGGTYNATWTPQNI 3291
+ ++ CGG T I
Sbjct: 574 FKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFI--TKLNGTI 631
Query: 3292 SSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSR 3350
+SP C W + +P ++ + +L D C ++++++
Sbjct: 632 TSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLH 691
Query: 3351 FQFCGRNASAVPVFYSSMSTAM-VIFKSG--VVNRNSRMSFTYQIADCNRDY-------- 3399
+FCG S P +S S M V FKS V R R F +C +D
Sbjct: 692 GRFCG---SETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECV 748
Query: 3400 -----------------------------HKAF---GNLRSPGWPDNYDNDKDCTVTLTA 3427
HK G L SP WPD Y + ++CT +++
Sbjct: 749 NTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISS 808
Query: 3428 PQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYL 3487
H + L F+ IE EC D LE+ +G +S +P+LG++CG+ P+P + + ++L
Sbjct: 809 TAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFL 868
Query: 3488 RFKSDSVTSDRGYEIIWTSSPSGCGGTLYGD---RGSFTSPGY-PGTYPNNTYCEWVLVA 3543
RF SD+ +G++ + ++ CGG L + + ++ + YP+ C+WV+VA
Sbjct: 869 RFYSDASVQRKGFQAVHSTE---CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVA 925
Query: 3544 PAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVF 3603
G V + F +++ DC +Y+ YDG ++S+P G +CG + ++ + +
Sbjct: 926 EDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSG-PLEEIYSAGDSLM 984
Query: 3604 IKFHADYARRPSAFRLTWDS 3623
I+F D F + S
Sbjct: 985 IRFRTDDTINKKGFHARYTS 1004
Score = 223 bits (569), Expect = 2e-57
Identities = 168/676 (24%), Positives = 279/676 (41%), Gaps = 105/676 (15%)
Query: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Y CG + +G + G P Y C W + G + ++F +L S C
Sbjct: 346 YKCPACGETLQDTTGNFSAPGFPN-GYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404
Query: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
D+VE+ D + +LGR+CG+ IP+ + ++ + V F + ++ GF +E++
Sbjct: 405 WYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT- 463
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
CGGD+ G SPNYP+ + C WRIT EG + L F + H SC ++
Sbjct: 464 --CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDY 521
Query: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
+ V +G S + C ++KSS N + + F +DGS GF A++ D
Sbjct: 522 LEVRDGPTEESALIGHFC-GYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580
Query: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
CGG + G TSPG+
Sbjct: 581 SWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKL-NGTITSPGWP-- 637
Query: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
+ Y N NC W + P Q IS+ FE F LE + C++D +E R G D L R C
Sbjct: 638 KEYPTNKNCVWQVVAPAQ--YRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFC 695
Query: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------SFTDCGGIQ---------- 2693
G P + + + + + F ++ V GF A + D GG Q
Sbjct: 696 GSETPEV-ITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSY 754
Query: 2694 --------------------------IGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTI 2727
G + SPN+P+ Y S C+ + + GH +
Sbjct: 755 LCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRV 814
Query: 2728 TLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDH 2787
LTF++F+IE H CA+D + + +G +PI+G++CG+ P + + + + F SD
Sbjct: 815 KLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDA 874
Query: 2788 SLQGGGFYATWNTQTLGCGGIFHSDNGT----IRSPHWPQNFPENSRCSWTAITHKSKHL 2843
S+Q GF A +T+ CGG ++ T + N+P +RC W + +
Sbjct: 875 SVQRKGFQAVHSTE---CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGV 931
Query: 2844 EISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQ 2903
E++F F + + C +++ + G + L CG+ + + ++ F+
Sbjct: 932 ELTF-RTFEVEE-EADCGYDYMEAYDGYDS-SAPRLGRFCGSGPLEEIYSAGDSLMIRFR 988
Query: 2904 SQEA-PAQGFSASFVS 2918
+ + +GF A + S
Sbjct: 989 TDDTINKKGFHARYTS 1004
Score = 204 bits (519), Expect = 1e-51
Identities = 165/657 (25%), Positives = 272/657 (41%), Gaps = 102/657 (15%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
CG G +P +P +P S C W + + ++F + L S C +
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSR--LCWYDY 408
Query: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQE-APAQGFSASFVSRCGSN 2923
V+V G LL CG+ P P+++ + F+S +GF A++ + CG +
Sbjct: 409 VEVRDGYWR-KAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGD 467
Query: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
+G I SPNYP Y + C + I + V LTF +F +E SC D +
Sbjct: 468 MNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHD----SCAYDYLE 523
Query: 2984 IIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKF------------ 3030
+ G + S CG E P + + L + F S+ I GF
Sbjct: 524 VRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 3031 --------------SYRI----------------ISCGGVFNFSSGIITSPAYSYADYPN 3060
SY+ ++CGG +G ITSP + +YP
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWP-KEYPT 642
Query: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
+ +C++ + I L+F F++ + C +D++ + G + L G+FCGS+ P
Sbjct: 643 NKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEV 702
Query: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSF--------RQTLGPQQGC----GGYLTGSNN-- 3166
+ S +N+M + FK+D+ + +G++ F + G Q C G YL N
Sbjct: 703 ITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGY 762
Query: 3167 -----------------------TFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNT 3203
T ASP+ Y C W I + + LTFN
Sbjct: 763 WLHENGHDCKEAGCAHKISSVEGTLASPNWPDK--YPSRRECTWNISSTAGHRVKLTFNE 820
Query: 3204 FALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLE 3263
F +E Q C YD++++YDG A + G FCGS P P ++SG+ + ++F SD +++
Sbjct: 821 FEIE---QHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQ 877
Query: 3264 REGFNATYTIMDMPCGGTYNA-TWTPQNISSPNSSDPDVPFSI-CTWVIDSPPHQQVKIT 3321
R+GF A ++ CGG A T + S D + P C WVI + V++T
Sbjct: 878 RKGFQAVHS---TECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELT 934
Query: 3322 VWALQLTSQ-DCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKS 3377
++ + DC +Y++ D +FCG + + YS+ + M+ F++
Sbjct: 935 FRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCG--SGPLEEIYSAGDSLMIRFRT 989
Score = 191 bits (486), Expect = 9e-48
Identities = 130/544 (23%), Positives = 218/544 (40%), Gaps = 87/544 (15%)
Query: 471 QQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHE 530
+ CG ++ G + Y C W I G + +TF F +E D+C ++
Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 531 FLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPE- 589
+L+V DG + + +G FCG P ++ SS N L+ S+ N GF + + E
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580
Query: 590 ---------------------------------------CGGILTGPYGSIKSPGYPGNY 610
CGG +T G+I SPG+P Y
Sbjct: 581 SWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEY 640
Query: 611 PPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSV 670
P ++CVW VV ++ F LE +D C D++E+R G L G+FC + +
Sbjct: 641 PTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETP 700
Query: 671 PPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSD--------------------LRCGG 710
+ + R+ F SD+ +S +GF + + + RC
Sbjct: 701 EVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRN 760
Query: 711 NY------------------TDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTH 752
Y + EG L P + R+C + + G ++++ F
Sbjct: 761 GYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNE 820
Query: 753 VELQCQSDSSQNYIEVRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKAS 808
E++ + + +++E+ DG +LG+ CG+ + +S+++RF DASV++
Sbjct: 821 FEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKG 880
Query: 809 FRAVYQVACGDEL-----TGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEI 863
F+AV+ CG L T E + F N YP E C W I + L F FE+
Sbjct: 881 FQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEV 940
Query: 864 GSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMA 923
A C DY+E +P ++CG+ I S + L + F + GF A
Sbjct: 941 EEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHA 1000
Query: 924 KFSA 927
++++
Sbjct: 1001 RYTS 1004
Score = 162 bits (409), Expect = 7e-39
Identities = 109/422 (25%), Positives = 183/422 (43%), Gaps = 66/422 (15%)
Query: 447 CVDGVDSFSCECTRLWTGA----LCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFW 502
CV+ + S+ C C + A +C+V CG ++ +NG+ + Y + NC W
Sbjct: 592 CVNTLGSYKCACDPGYELAADKKMCEV---ACGGFITKLNGTITSPGWPKEYPTNKNCVW 648
Query: 503 VIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDN 562
+ + + F F LE D C ++F++V G S A GRFCGS P + S N
Sbjct: 649 QVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSN 708
Query: 563 ALYFHLYSEHLRNGRGFTVRWETQQPEC----GGI------------------------- 593
+ S++ + RGF + + + EC GG
Sbjct: 709 NMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENG 768
Query: 594 -----------LTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD 642
++ G++ SP +P YP R+C W + ++ V TF +E H +
Sbjct: 769 HDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQE 828
Query: 643 CNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTS 702
C D+LE+ DGP P+LG+FC + P +G + F+SD+ + +GF + T
Sbjct: 829 CAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST- 887
Query: 703 PSDLRCGGNYTDPEGELFLPEL-------SGPFTHTRQCVYMMKQPQGEQIQINFTHVEL 755
CGG + E+ EL + +C +++ G +++ F E+
Sbjct: 888 ----ECGGRL---KAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEV 940
Query: 756 QCQSDSSQNYIEVRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRA 811
+ ++D +Y+E DG LG+ CG+G + I S +S+ IRF+ D ++ K F A
Sbjct: 941 EEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHA 1000
Query: 812 VY 813
Y
Sbjct: 1001 RY 1002
Score = 130 bits (327), Expect = 2e-29
Identities = 83/280 (29%), Positives = 128/280 (45%), Gaps = 19/280 (6%)
Query: 434 NECLSNPCLNGGT---CVDGVDSFSCECTR-LW---TGALCQVPQQVCGESLSGINGSFS 486
+EC + NGG CV+ S+ C C W G C+ + C +S + G+ +
Sbjct: 734 DECAKD---NGGCQHECVNTFGSYLCRCRNGYWLHENGHDCK--EAGCAHKISSVEGTLA 788
Query: 487 YRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLG 546
+ Y C W I + G +++TF F +E C ++ L++YDG S A LG
Sbjct: 789 SPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILG 848
Query: 547 RFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGY 606
RFCGS P ++S ++++ YS+ +GF T ECGG L + + +
Sbjct: 849 RFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST---ECGGRLKAEVQTKELYSH 905
Query: 607 ----PGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLG 662
NYP C W++V V TF T +E DC DY+E DG P LG
Sbjct: 906 AQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLG 965
Query: 663 KFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTS 702
+FC + + + + G I F +D I+ +GFH Y ++
Sbjct: 966 RFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTST 1005
Score = 37.0 bits (84), Expect = 0.36
Identities = 58/215 (26%), Positives = 79/215 (36%), Gaps = 49/215 (22%)
Query: 190 CVNTMGSYSCHCPPETYGPQCASKYDDCE---GGSVAR-------------------CVH 227
CVNT+GSY C C P G + A+ CE GG + + CV
Sbjct: 592 CVNTLGSYKCACDP---GYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVW 648
Query: 228 GICEDL-----MREQAGEPKYSCVC--DAGWMFSPNSPACTLDRDECSFQPGPCSTLVQC 280
+ ++ + E + + VC D + S SP L C + T Q
Sbjct: 649 QVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITS-QS 707
Query: 281 FNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGY 340
N + F + + D +EC +NGGC ECVNT GS C+ C GY
Sbjct: 708 NNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQ----HECVNTFGSYLCR-CRNGY 762
Query: 341 --QGDGRVCTLTDICSVSNGGC-HPDASCSSTLGS 372
+G C GC H +S TL S
Sbjct: 763 WLHENGHDC--------KEAGCAHKISSVEGTLAS 789
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 311 bits (798), Expect = 6e-84
Identities = 210/686 (30%), Positives = 323/686 (47%), Gaps = 96/686 (13%)
Query: 1606 SRQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHI 1660
+R ++G AQ R+ ACG L S SSP +P Y + +C W I P I
Sbjct: 303 TRLSKGDIAQARKLYKCPACG-ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPG-EKI 360
Query: 1661 TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDS 1720
L+FT +L RS C D+VE+ DG APLRGR+CG+ +P PI S S L + F S S
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 1721 SISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSF 1780
+ GF A CGG G SP YPD Y P+ C+W I S G + L+F
Sbjct: 421 NWVGKGFFAVYEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
Query: 1781 ISFQLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGS 1839
SF++E C+ D++E+R+G++ + L+GRYCG P + S LW++F+SDGS +
Sbjct: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS-TSSRLWLKFVSDGSIN 536
Query: 1840 GTGFQATFMKIFGND-------------NIVGTH-------------------------- 1860
GF F K N +G++
Sbjct: 537 KAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLT 596
Query: 1861 ---GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917
G + SP WP+ YP N N W + + + + + E C YD + + G +
Sbjct: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656
Query: 1918 IHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWFA---------VDAPD 1967
++L G +CG++ E +S N++ F SD+++S KGF +F+
Sbjct: 657 ADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQ 716
Query: 1968 GVLPTIAPGAC---GGFL---------------RTGDAPVFLFSPGWPDSYSNRVDCTWL 2009
+ T C GF+ + + SP WPD Y ++ +CTW
Sbjct: 717 DCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWA 776
Query: 2010 IQA-PDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEY 2068
I + P V+L + +DIES CAYD L + DG + A L CG + P P+ +TG
Sbjct: 777 ISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSR 836
Query: 2069 MFIRFTSDSSVTRAGFNASFHKSCGGYLHAD---RGIITSPKYPE-TYPSNLNCSWHVLV 2124
MF+RF SD+SV R GF AS CGG + AD + + + ++ + YP ++C W ++
Sbjct: 837 MFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVA 896
Query: 2125 QSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTL 2184
+ G + + F Q F++ ++ C DY+ L +G D +P L G +CGS +
Sbjct: 897 EEGYGVELVF-QTFEVEE-ETDCGY-DYMELFDGYDSTAPRL------GRYCGSGPPEEV 947
Query: 2185 FTSDNQMFVQFISDHSNEGQGFKIKY 2210
+++ + + V+F SD + +GF ++Y
Sbjct: 948 YSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 310 bits (794), Expect = 2e-83
Identities = 206/670 (30%), Positives = 302/670 (45%), Gaps = 109/670 (16%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
CG Q +G SP YP+ Y ++ C W I V +++LNFT DL C Y
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
DG R CG +L PIVS+ + L++ F+S + +GF A + CGG +
Sbjct: 382 VRDGFWRKAPLRGRFCG-SKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV- 439
Query: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
+ + SP +P +Y ++ C W IQ H+ L+F FE+ER +CA D++E+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGF-HVGLTFQSFEIERHDSCAYDYLEVRDG 498
Query: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASV---------- 1735
E + L GRYCG + P I S SS L L+FVSD SI+ GF V
Sbjct: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1736 ------------------------------SACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
+ACGG G SPG+P YPPN C+
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
W +V+ R+ L F F+ E + C DFVE+R G A L G++CG+ P +S
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY 678
Query: 1825 GHTLWVRFISDGSGSGTGFQATF------------------MKIFG------------ND 1854
+ + V F SD + S GF+A F + FG +D
Sbjct: 679 -NNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHD 737
Query: 1855 N------------IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEI 1902
N + T G + SP WP+ YP W ++ H V +EMDIE
Sbjct: 738 NKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQ 797
Query: 1903 QNCYYDKLRIYDGPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWF 1961
C YD L ++DG A ++G +CG+ + E +TG+ + FYSD+S+ KGF
Sbjct: 798 PECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQ---- 853
Query: 1962 AVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPG--WPDSYSNRVDCTWLIQAPDS-TVE 2018
A A + CGG +R L+S ++Y VDC W+I A + VE
Sbjct: 854 ASHATE----------CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVE 903
Query: 2019 LNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSS 2078
L + ++E C YD + + DG ++ A +L CG P + S G+ + ++F SD +
Sbjct: 904 LVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 963
Query: 2079 VTRAGFNASF 2088
+T+ GF+ +
Sbjct: 964 ITKKGFHLRY 973
Score = 307 bits (787), Expect = 1e-82
Identities = 197/663 (29%), Positives = 297/663 (44%), Gaps = 101/663 (15%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CG L S+G F SP YP Y C W + + G L F L C DY+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
V DG + L + CG + P I S+ ++++ R+ G+GF A Y C V
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV-- 439
Query: 1285 NQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP 1344
+ YG ++S YP+ Y ++ C W I+ + G V TF +F++E H +C+ DYLE+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGH 499
Query: 1345 RQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVY----------- 1389
+ +GRYCG + P +TSS+L + ++DG + GF + +F
Sbjct: 500 SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDG-SINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1390 -------------------------------GCGGELSGATGSFSSPGFPNRYPPNKECI 1418
CGG L+ GS +SPG+P YPPNK CI
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1419 WYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVS 1478
W + I L F+ E + C +D +E+ G S + C PE ++
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE---VIT 675
Query: 1479 STGNELAIRFKTDLSINGRGFNASW---------------------------QAVTG--- 1508
S N + + FK+D +++ +GF A + Q +G
Sbjct: 676 SQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVL 735
Query: 1509 ----------GCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE 1558
GC + SG I SPN+P Y S +C+W I HRV L F + D+E
Sbjct: 736 HDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIE 795
Query: 1559 PQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRA 1614
Q C + +DG + L R CG ++ P++++G+ +FLRF S S Q +GF+A
Sbjct: 796 SQPECAYDHLEVFDGRDAKAPVLGRFCGSKK-PEPVLATGSRMFLRFYSDNSVQRKGFQA 854
Query: 1615 QFRQACGGHILTS--SFDTVSSPRF-PANYPNNQNCSWIIQAQPPLNHITLSFTHFELER 1671
CGG + + D S +F NYP +C W+I A+ + L F FE+E
Sbjct: 855 SHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYG-VELVFQTFEVEE 913
Query: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV 1731
T C D++E+ DG AP GRYCG+ P + S ++ ++F SD +I+ GFH
Sbjct: 914 ETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Query: 1732 TAS 1734
T++
Sbjct: 974 TST 976
Score = 292 bits (747), Expect = 5e-78
Identities = 187/665 (28%), Positives = 306/665 (46%), Gaps = 107/665 (16%)
Query: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
AC + D G F+SP +PN Y + C++RI+V G+ I ++FT+ L + +Y D+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY-DY 379
Query: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
+E+RDG + K+PL G F GS LP I+S ++LW++F+S GF A ++ CG
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---CG 436
Query: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
G++ G SPNYP Y S C W ++ S G L F+ F +E H +C DYL V
Sbjct: 437 GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVR 496
Query: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY------------ 1274
DG S +S L+ + CG EKP I+S+ +++K +D GF +
Sbjct: 497 DGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNR 556
Query: 1275 ---RQTCENVV--------------------------IVNQTYGILESIGYPNPYSENQH 1305
Q C N + + + G + S G+P Y N++
Sbjct: 557 GGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
Query: 1306 CNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGST 1361
C W + A T ++ F F+ E + C D++E+ G + G++CG + P ++
Sbjct: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
Query: 1362 TSSKLQVLLLTDGVGRREKGFQMQWF---------------------------------- 1387
+ ++V +D + KGF+ +F
Sbjct: 677 QYNNMRVEFKSDNTVSK-KGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVL 735
Query: 1388 --------VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
GC +++ +G+ +SP +P++YP KEC W I + PG ++LT + D+E
Sbjct: 736 HDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIE 795
Query: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
C +D LE++ G D +P + + C + PE V +TG+ + +RF +D S+ +GF
Sbjct: 796 SQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPE---PVLATGSRMFLRFYSDNSVQRKGF 852
Query: 1500 NASWQAVTGGCGGIFQAPSGE----IHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDF 1555
AS CGG +A H+ + Y DC WVI + + V L F F
Sbjct: 853 QASHAT---ECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTF 909
Query: 1556 DLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRG 1611
++E + C + +DG ST RL R CG + S+G+S+ ++F S + +G
Sbjct: 910 EVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGP-PEEVYSAGDSVLVKFHSDDTITKKG 968
Query: 1612 FRAQF 1616
F ++
Sbjct: 969 FHLRY 973
Score = 290 bits (742), Expect = 2e-77
Identities = 200/669 (29%), Positives = 300/669 (44%), Gaps = 102/669 (15%)
Query: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
CG L +TG+FSSP +PN Y + C+W I PG I L D+ C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
+ G +P + C + PE + ST + L + F++ + G+GF A ++A+ C
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPE---PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---C 435
Query: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
GG + G I SPNYP YR + C W I+V V L F F++E DSC Y
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
DG S + + + R CG E+ + I S+ + L+L+F S S GF F
Sbjct: 496 RDGHSESSTLIGRYCGYEK-PDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
ACGG LT +++SP +P YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWPKEYPP 613
Query: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
N+NC W + A P I+L F FE E + C DFVE+ G D+ L G++CG++ P
Sbjct: 614 NKNCIWQLVA-PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 672
Query: 1704 PITSFSSALTLRFVSDSSISAGGFHTTVTASVSAC----GG-------TFYMAE------ 1746
ITS + + + F SD+++S GF + C GG TF E
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSG 732
Query: 1747 -----------------------GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISF 1783
G SP +PD YP EC W I S+PG+R++L+F+
Sbjct: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
Query: 1784 QLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG 1842
+E +C+ D +E+ +G +A ++GR+CG+ P + G +++RF SD S G
Sbjct: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLA-TGSRMFLRFYSDNSVQRKG 851
Query: 1843 FQATFMKIFGNDNIVGTHGKVA---SPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDI 1899
FQA+ G K + F NYP + +W + + V ++
Sbjct: 852 FQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEV 911
Query: 1900 EEIQNCYYDKLRIYDGPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLL 1958
EE +C YD + ++DG A +G YCG+ E S G+S+ F+SD +I+ KGF L
Sbjct: 912 EEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHL 971
Query: 1959 EWFAVDAPD 1967
+ + D
Sbjct: 972 RYTSTKFQD 980
Score = 290 bits (741), Expect = 2e-77
Identities = 197/661 (29%), Positives = 300/661 (45%), Gaps = 102/661 (15%)
Query: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
ACGE L +STG SP +PN Y ++C W I V P I L F + L C DY+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
EV D + GR+CG +P + S+ + L + F + S+ +GF YEAI C
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-----C 435
Query: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
D D G SPN+P++Y + CI+RI V G + + F +F +E Y D+LE
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYLE 494
Query: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWD--------- 1159
+RDG E S L+G + G P I S S++LWLKF SD ++GF+ +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188
GS CGG LT +G+ SP +P Y +
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
C W L + L+F F E + C D++ V G +++S L + CG EKP +I
Sbjct: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
Query: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEY--------------RQTCENVV------------ 1282
S ++M ++ ++D +GFKA + +Q C N
Sbjct: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFV 734
Query: 1283 ---------------IVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDL 1327
V T G + S +P+ Y + C W I +T G+ V TF+ D+
Sbjct: 735 LHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDI 794
Query: 1328 EHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQ 1383
E C+ D+LE++DG +GR+CG P P T S++ + +D +R KGFQ
Sbjct: 795 ESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQR-KGFQ 853
Query: 1384 MQWFVYGCGGELSGATGS---FSSPGF-PNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
CGG++ + +S F N YP +C W I + G ++L F+VE
Sbjct: 854 AS-HATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVE 912
Query: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
+ C +D +E++ G D +PR+ + C PE +V S G+ + ++F +D +I +GF
Sbjct: 913 EETDCGYDYMELFDGYDSTAPRLGRYCGSGPPE---EVYSAGDSVLVKFHSDDTITKKGF 969
Query: 1500 N 1500
+
Sbjct: 970 H 970
Score = 289 bits (740), Expect = 3e-77
Identities = 192/673 (28%), Positives = 310/673 (46%), Gaps = 112/673 (16%)
Query: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
G +SP +P Y + + W ++V + +D+ + C+YD + + DG A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
Query: 1921 RLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACG 1979
L G +CG++ E ST + L F S S+ GKGF + A+ CG
Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI--------------CG 436
Query: 1980 GFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLV 2038
G ++ + SP +PD Y C W IQ + V L S +IE H +CAYD L
Sbjct: 437 GDVKKDYGHIQ--SPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 2039 IRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK-------- 2090
+RDG + + + CG E P I+ST ++++F SD S+ +AGF +F K
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 2091 -----------------------------------SCGGYLHADRGIITSPKYPETYPSN 2115
+CGG+L G ITSP +P+ YP N
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 2116 LNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHF 2175
NC W ++ + I++ F+ F G+ C D++ +R+G S +G F
Sbjct: 615 KNCIWQLVAPTQYRISLQFD--FFETEGNDVCKY-DFVEVRSGLTADSKL------HGKF 665
Query: 2176 CGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLAC----GG------------ 2219
CGS + + N M V+F SD++ +GFK + + C GG
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSY 725
Query: 2220 ------NVYIHD--------------ADSAGYVTSPNHPHNYPPHADCIWILAAPPETRI 2259
+HD ++G +TSPN P YP +C W +++ P R+
Sbjct: 726 ECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV 785
Query: 2260 QLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSD 2319
+L F + DIE P C ++LE+ DG D+ AP+L +FCG+ P ++G M+LRF SD
Sbjct: 786 KLTFME-MDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSD 844
Query: 2320 NSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTL---PYRDNLFCEWHLQGLSGHYLT 2376
NS GF+A ++ +CGG+V + H Y + CEW + G+ +
Sbjct: 845 NSVQRKGFQASHA-TECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVE 903
Query: 2377 ISFEDFNLQNSSGCEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVTDGS 2435
+ F+ F ++ + C D++E++D + S LGRYCG+ P+ + ++ ++ +V+F +D +
Sbjct: 904 LVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 963
Query: 2436 VTASGFRLRFESS 2448
+T GF LR+ S+
Sbjct: 964 ITKKGFHLRYTST 976
Score = 274 bits (701), Expect = 1e-72
Identities = 197/673 (29%), Positives = 298/673 (44%), Gaps = 110/673 (16%)
Query: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQDC 2628
CG +L ++ GNF+SP Y YS +++C W +S P + I ++F L + C
Sbjct: 322 CGETLQDST-GNFSSPEYPN--GYSAHMHCVWRISVTPGE---KIILNFTSLDLYRSRLC 375
Query: 2629 QFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT 2687
+D +E R G PL R CG P P+V S++W+ F ++ GF A Y
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Query: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747
CGG D G I SPNYP+ Y C ++ +G + LTF F+IE H +CA+D +
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 2748 TVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ------ 2801
VR+G S S +IG+YCG P I+S S++L + F SD S+ GF + +
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 2802 ------------TLG----------------------CGGIFHSDNGTIRSPHWPQNFPE 2827
TLG CGG NG+I SP WP+ +P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 2828 NSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVA 2887
N C W + + + FD F G+ C+ FV+V +G D L CG+
Sbjct: 614 NKNCIWQLVAPTQYRISLQFD--FFETEGNDVCKYDFVEVRSGLT-ADSKLHGKFCGSEK 670
Query: 2888 PGPVITPSNTFTAVFQSQEAPAQ-GFSASFVS-------------------------RCG 2921
P + + N F+S ++ GF A F S +C
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCR 730
Query: 2922 SNF------------------TGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFV 2963
S F T SG I SPN+P +Y + CT+ I + P V LTF+
Sbjct: 731 SGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFM 790
Query: 2964 SFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGP-VLLNFYSNEQ 3022
+E++ C D + + G + CG + P P+ G + L FYS+
Sbjct: 791 EMDIESQP----ECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNS 846
Query: 3023 ITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYA-----DYPNDMHCLYTITVSDDKVIE 3077
+ GF+ S+ CGG + + T YS+A +YP + C + I + +E
Sbjct: 847 VQRKGFQASHAT-ECGG--QVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVE 903
Query: 3078 LKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSF 3137
L F F+V T C +DY+ ++DG +++ P LG++CGS P V S+ +S+L+ F +D
Sbjct: 904 LVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 963
Query: 3138 QTAKGWKMSFRQT 3150
T KG+ + + T
Sbjct: 964 ITKKGFHLRYTST 976
Score = 271 bits (693), Expect = 9e-72
Identities = 187/683 (27%), Positives = 307/683 (44%), Gaps = 120/683 (17%)
Query: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272
K ACG + DS G +SP +P+ Y H C+W ++ P +I L F D+ +
Sbjct: 318 KCPACGETLQ----DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS-LDLYRS 372
Query: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332
C +Y+E+RDG AP+ +FCG+ LP S+ +++ FRS ++ GF A Y
Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
Query: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392
A CGG V G ++S +P YR + C W +Q G ++ ++F+ F ++ C
Sbjct: 433 -AICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
Query: 2393 DFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451
D++E+ D H+ S ++GRYCG PD I ++S+ ++FV+DGS+ +GF + F ++E
Sbjct: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2452 ----------------------------------------CGGDLQGSIGTFTSPNYPNP 2471
CGG L G+ TSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
P + C W++ AP RI+L F+ + C + V V +G+ ++S K C S
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-E 669
Query: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED------------------------ 2567
I S N M+V F +D + GF A + S +D
Sbjct: 670 KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQC 729
Query: 2568 ---------------AVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSS 2612
A C + +T G TSP + Y C W +S +
Sbjct: 730 RSGFVLHDNKHDCKEAGCDHKVTST-SGTITSPNWPD--KYPSKKECTWAIS--STPGHR 784
Query: 2613 ISIHFEDFYLESHQDCQFDVLE-FRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVT 2671
+ + F + +ES +C +D LE F DA P++ R CG KP P++ S++++ F +
Sbjct: 785 VKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPE-PVLATGSRMFLRFYS 843
Query: 2672 NERVEHIGFHAKYSFTDCGG--------------IQIGDSGVITSPNYPNAYDSLTHCSS 2717
+ V+ GF A ++ T+CGG Q GD+ NYP D C
Sbjct: 844 DNSVQRKGFQASHA-TECGGQVRADVKTKDLYSHAQFGDN------NYPGGVD----CEW 892
Query: 2718 LLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSN 2777
++ A +G+ + L F F++E T C +D + + +G +P +G+YCG+ P + S +
Sbjct: 893 VIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGD 952
Query: 2778 QLVVTFNSDHSLQGGGFYATWNT 2800
++V F+SD ++ GF+ + +
Sbjct: 953 SVLVKFHSDDTITKKGFHLRYTS 975
Score = 271 bits (693), Expect = 9e-72
Identities = 193/682 (28%), Positives = 301/682 (44%), Gaps = 117/682 (17%)
Query: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
ACG L+ D+ SP +P+ YS + C W I P + LN SLD+ R C YD
Sbjct: 321 ACGETLQ--DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
+ +RDG A CG ++P PI ST +++ F S S+ GF A + CGG
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
Query: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
+ D G I SP YP+ Y + C W + V G + + F Q F+I DS DYL +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDSCAY--DYLEV 495
Query: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
R+G S +G +CG + ++ ++++++F+SD S GF + +
Sbjct: 496 RDGHSESSTLIG------RYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
Query: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
E + L ACGG + G +TSP
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL----TKLNGSITSP 605
Query: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
P YPP+ +CIW L AP + RI LQF D F+ E C +++E+R G+ +D+ + K
Sbjct: 606 GWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY------------------------ 2331
FCG+ P S M + F+SDN+ + GFKA +
Sbjct: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGS 724
Query: 2332 ------------------SIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGH 2373
A C +V SG + S P Y C W + GH
Sbjct: 725 YECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPD-KYPSKKECTWAISSTPGH 783
Query: 2374 YLTISFEDFNLQNSSGCEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVT 2432
+ ++F + ++++ C D +E++D + +LGR+CG+ P+ + + + +RF +
Sbjct: 784 RVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYS 843
Query: 2433 DGSVTASGFRLRFESSMEECGGDLQGSIGT--------FTSPNYPNPNPHGRICEWRITA 2484
D SV GF+ S ECGG ++ + T F NYP G CEW I A
Sbjct: 844 DNSVQRKGFQA---SHATECGGQVRADVKTKDLYSHAQFGDNNYPG----GVDCEWVIVA 896
Query: 2485 PEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMK 2544
EG + L+F + C +++ +F+G S +P+L + C S E+ S+G+++
Sbjct: 897 EEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGS-GPPEEVYSAGDSVL 955
Query: 2545 VIFFTDGSRPYGGFTASYTSSE 2566
V F +D + GF YTS++
Sbjct: 956 VKFHSDDTITKKGFHLRYTSTK 977
Score = 269 bits (687), Expect = 4e-71
Identities = 184/688 (26%), Positives = 295/688 (42%), Gaps = 102/688 (14%)
Query: 448 VDGVDSFSCECTRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWV 503
V+GV + TRL G + Q + CGE+L G+FS GY ++C W
Sbjct: 292 VNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWR 351
Query: 504 IKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNA 563
I G+ + + FT L C +++++V DG A GRFCGS LP ++S+D+
Sbjct: 352 ISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSR 411
Query: 564 LYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTS 623
L+ S G+GF +E CGG + YG I+SP YP +Y P + C+W + S
Sbjct: 412 LWVEFRSSSNWVGKGFFAVYEAI---CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVS 468
Query: 624 PDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIH 683
V TF + +E HD C DYLE+RDG L+G++C +++T +
Sbjct: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
Query: 684 FHSDSQISDQGFHIT----------------------------------YLTSPSDLR-- 707
F SD I+ GF + Y +P R
Sbjct: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Query: 708 --CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
CGG T G + P + + C++ + P +I + F E + ++
Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
Query: 766 IEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY-------- 813
+EVR G T L GK CG+ I S N++ + FK D +V K F+A +
Sbjct: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECS 708
Query: 814 -----------------------------------QVACGDELTG-EGVIRSPFFPNVYP 837
+ C ++T G I SP +P+ YP
Sbjct: 709 KDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYP 768
Query: 838 GERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPS 897
++ C W I + L F +I S C D++E+ +P ++CG+ P
Sbjct: 769 SKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPE 828
Query: 898 FITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGH----PNVYP 953
+ + + +++ F +S + GF A + E CG + T H N YP
Sbjct: 829 PVLATGSRMFLRFYSDNSVQRKGFQASHATE---CGGQVRADVKTKDLYSHAQFGDNNYP 885
Query: 954 HGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKSIPP 1011
G++C W I+ + + + L+F+TF +E +C DY+E++D T+ LGRYCG P
Sbjct: 886 GGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPE 945
Query: 1012 SLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
+ S+G+S+++ F +D + +GF + Y
Sbjct: 946 EVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 265 bits (677), Expect = 6e-70
Identities = 184/663 (27%), Positives = 281/663 (42%), Gaps = 101/663 (15%)
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CG D G PE ++ CV+ + GE+I +NFT ++L +Y+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 768 VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823
VRDG L G+ CG+ I S + +W+ F+ ++ F AVY+ CG ++
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
Query: 824 E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882
+ G I+SP +P+ Y + C W I + + L F FEI C DY+E+
Sbjct: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
Query: 883 GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928
S +YCG + P I S + L++ FV S GF F E
Sbjct: 502 SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
Query: 929 --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962
+ ACG LT+ G+I SPG P YP NC W +
Sbjct: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 963 LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSL 1020
+ + I L F+ F E + C D++EV T G++CG P +TS N++
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNM 681
Query: 1021 MLVFVTDSDLAYEGFLINY-----EAISAATACLQD------------------------ 1051
+ F +D+ ++ +GF ++ E C QD
Sbjct: 682 RVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHD 741
Query: 1052 ---------YTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNY 1102
T GT TSPN+P+ YP+ EC + I+ G + + F +E
Sbjct: 742 CKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECA 801
Query: 1103 YTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSS 1162
Y D LE+ DG K+P+LG F GS P +++ ++++L+F SD R GF A +
Sbjct: 802 Y-DHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQA---SHA 857
Query: 1163 TGCGGNLTT--------SSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEH 1214
T CGG + S F NYP +C W + + G EL F+ F +E
Sbjct: 858 TECGGQVRADVKTKDLYSHAQFGDNNYP----GGVDCEWVIVAEEGYGVELVFQTFEVEE 913
Query: 1215 HPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
+C DY+ ++DG S + L + CG P + S+GDS+ +K +D+ +GF Y
Sbjct: 914 ETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Query: 1275 RQT 1277
T
Sbjct: 974 TST 976
Score = 247 bits (630), Expect = 2e-64
Identities = 179/682 (26%), Positives = 299/682 (43%), Gaps = 111/682 (16%)
Query: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
+CG L G +SP+YP Y ++++C W + V G I ++F + S
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS---LDLYRSRLCWY 377
Query: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
DY+ +R+G +P G FCGS + ++D++++V+F S + G+GF Y
Sbjct: 378 DYVEVRDGFWRKAPL------RGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
Query: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270
EA CGG+V G++ SPN+P +Y P CIW + + L F+ F+IE
Sbjct: 432 EA---ICGGDV----KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIE 483
Query: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330
+C +YLE+RDG + ++ ++CG P S+ ++L+F SD S GF
Sbjct: 484 RHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVN 543
Query: 2331 Y------------------------------------------SIAQCGGRVPGQSGVVE 2348
+ A CGG + +G +
Sbjct: 544 FFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSIT 603
Query: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNIL- 2407
S G P Y N C W L + + +++ F+ F + + C+ DFVE+ T+ + L
Sbjct: 604 SPGWPK-EYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLH 662
Query: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQG--------- 2458
G++CG+ P+ I + N V F +D +V+ GF+ F S +EC D G
Sbjct: 663 GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTF 722
Query: 2459 -------------------------------SIGTFTSPNYPNPNPHGRICEWRITAPEG 2487
+ GT TSPN+P+ P + C W I++ G
Sbjct: 723 GSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPG 782
Query: 2488 RRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIF 2547
R+ L F + + + P C +H+ VF+G + +P L + C S + ++G+ M + F
Sbjct: 783 HRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGS-KKPEPVLATGSRMFLRF 841
Query: 2548 FTDGSRPYGGFTASYTSSEDAVCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 2606
++D S GF AS+ + CGG + + + S G NY ++CEW +
Sbjct: 842 YSDNSVQRKGFQASHATE----CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVI--V 895
Query: 2607 NQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLCGPSKPTLPLVIPYSQV 2665
+ + + F+ F +E DC +D +E G D+ P + R CG S P + V
Sbjct: 896 AEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCG-SGPPEEVYSAGDSV 954
Query: 2666 WIHFVTNERVEHIGFHAKYSFT 2687
+ F +++ + GFH +Y+ T
Sbjct: 955 LVKFHSDDTITKKGFHLRYTST 976
Score = 241 bits (616), Expect = 7e-63
Identities = 171/677 (25%), Positives = 294/677 (43%), Gaps = 103/677 (15%)
Query: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Y+ +CG S+G +SP Y Y MHC++ I+V+ + I L F+ D+ S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+DY+ + DG PL G+FCGSK P + S+++ + + F++ S KG+ +
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
CGG + SP+ + Y + C+W I + LTF +F +E +
Sbjct: 435 -----CGGDVKKDYGHIQSPNYPDD--YRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
Query: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YDY+++ DG SE++ L G +CG P S+ + L ++F+SD ++ + GF +
Sbjct: 488 ---CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Query: 3272 TIMDMPCG---------------GTYNATWTPQ-----------------------NISS 3293
C G+Y + P +I+S
Sbjct: 545 FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
Query: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
P P C W + +P ++ + + D C ++++++ +
Sbjct: 605 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 3353 FCGRNASAVPVFYSSMSTAMVIFKSG--VVNRNSRMSFTYQIADCNRDY----------- 3399
FCG + V S + V FKS V + + F +C++D
Sbjct: 665 FCG--SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTF 722
Query: 3400 --------------------------HKAF---GNLRSPGWPDNYDNDKDCTVTLTAPQN 3430
HK G + SP WPD Y + K+CT +++
Sbjct: 723 GSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPG 782
Query: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490
H + L F + IE+ EC D LEV +G ++ +P+LG++CG+ P PV + + ++LRF
Sbjct: 783 HRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFY 842
Query: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGD---RGSFTSPGY-PGTYPNNTYCEWVLVAPAG 3546
SD+ +G++ S + CGG + D + ++ + YP CEWV+VA G
Sbjct: 843 SDNSVQRKGFQ---ASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEG 899
Query: 3547 RLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKF 3606
V + F +++ DC +Y+ L+DG ++++P G YCG + ++ + V +KF
Sbjct: 900 YGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVY-SAGDSVLVKF 958
Query: 3607 HADYARRPSAFRLTWDS 3623
H+D F L + S
Sbjct: 959 HSDDTITKKGFHLRYTS 975
Score = 236 bits (603), Expect = 2e-61
Identities = 178/676 (26%), Positives = 285/676 (42%), Gaps = 109/676 (16%)
Query: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979
CG +G SP YP Y +M+C + I P ++L F S L RS + C
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY-RSRL---CWY 377
Query: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038
D V + G+ + CG ++P P+ L + F S+ GF Y I CG
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
Query: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098
G G I SP Y DY C++ I VS+ + L F F++ SC++DYL +
Sbjct: 437 GDVKKDYGHIQSPNYP-DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQ--------- 3149
DG + S L+G++CG ++P ++KS+++ + L F +D G+ ++F +
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
Query: 3150 ----------TLGP------------------QQGCGGYLTGSNNTFASPDSDSNGMYDK 3181
TLG + CGG+LT N + SP Y
Sbjct: 556 RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE--YPP 613
Query: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241
N NC+W ++AP I L F+ F E C YD+V++ G + ++ L G FCGS
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDV---CKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 3242 PAPFISSGNFLTVQFISDLTLEREGFNA----------------------TYTIMDMPC- 3278
P S N + V+F SD T+ ++GF A T+ + C
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCR 730
Query: 3279 ---------------GGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVW 3323
G + T T I+SPN D CTW I S P +VK+T
Sbjct: 731 SGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFM 790
Query: 3324 ALQLTSQ-DCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNR 3382
+ + SQ +C ++L++ D +FCG + PV + + + V R
Sbjct: 791 EMDIESQPECAYDHLEVFDGRDAKAPVLGRFCG-SKKPEPVLATGSRMFLRFYSDNSVQR 849
Query: 3383 NSRMSFTYQIADCNRDY-----------HKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNH 3431
+ +C H FG+ +NY DC + A + +
Sbjct: 850 KGFQAS--HATECGGQVRADVKTKDLYSHAQFGD-------NNYPGGVDCEWVIVAEEGY 900
Query: 3432 TISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKS 3491
+ L F + +E +C D++E+ +G +S +P LG+YCG+ P V+S + + ++F S
Sbjct: 901 GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS 960
Query: 3492 DSVTSDRGYEIIWTSS 3507
D + +G+ + +TS+
Sbjct: 961 DDTITKKGFHLRYTST 976
Score = 228 bits (582), Expect = 6e-59
Identities = 171/676 (25%), Positives = 285/676 (42%), Gaps = 105/676 (15%)
Query: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Y CG + +G S +P Y ++ C W + G + ++F +L S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPN-GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
D+VE+ D + GR+CG+ +P+ I ++ + V F + + GF +E+
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
CGGD++ G SPNYP+ ++C WRI EG + L F + + H SC ++
Sbjct: 435 --CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
Query: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
+ V +G +S + + C ++IKS+ + + + F +DGS GF ++ D
Sbjct: 493 LEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
A CGG L G+ TSPG+
Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NGSITSPGWP-- 608
Query: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
+ Y N NC W L P Q IS+ F+ F E + C++D +E R G AD L + C
Sbjct: 609 KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------SFTDCGGIQ---------- 2693
G KP + + Y+ + + F ++ V GF A + D GG Q
Sbjct: 667 GSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSY 725
Query: 2694 --------------------------IGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTI 2727
SG ITSPN+P+ Y S C+ + + GH +
Sbjct: 726 ECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV 785
Query: 2728 TLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDH 2787
LTF + DIE CA+D + V +G ++P++G++CG+ P + + +++ + F SD+
Sbjct: 786 KLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDN 845
Query: 2788 SLQGGGFYATWNTQTLGCGGIFHSDNGT----IRSPHWPQNFPENSRCSWTAITHKSKHL 2843
S+Q GF A+ T+ CGG +D T + N+P C W + + +
Sbjct: 846 SVQRKGFQASHATE---CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGV 902
Query: 2844 EISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQ 2903
E+ F + D C +++++ G + L CG+ P V + ++ F
Sbjct: 903 ELVFQTFEVEEETD--CGYDYMELFDGYDST-APRLGRYCGSGPPEEVYSAGDSVLVKFH 959
Query: 2904 SQEA-PAQGFSASFVS 2918
S + +GF + S
Sbjct: 960 SDDTITKKGFHLRYTS 975
Score = 207 bits (528), Expect = 1e-52
Identities = 172/670 (25%), Positives = 270/670 (40%), Gaps = 107/670 (15%)
Query: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
CG LQ S G F+SP YPN C WRI+ G +I L F +L L C ++V
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCG 2571
V +G +P + C S + I S+ + + V F + + GF A Y +A+CG
Sbjct: 382 VRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----EAICG 436
Query: 2572 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD 2631
G + G+ SP Y +Y + C W + + + F+ F +E H C +D
Sbjct: 437 GDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCAYD 491
Query: 2632 VLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------ 2684
LE R G ++ L+ R CG KP + S++W+ FV++ + GF +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2685 ------------------------------------SFTDCGGIQIGDSGVITSPNYPNA 2708
CGG +G ITSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2709 YDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Y +C L AP + I+L F F+ E + C +D V VR+G + +S + G++CG+
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYATW------------------------------ 2798
P I S N + V F SD+++ GF A +
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCR 730
Query: 2799 ----------NTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFD 2848
+ + GC S +GTI SP+WP +P C+W + ++++F
Sbjct: 731 SGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFM 790
Query: 2849 NNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVI-TPSNTFTAVFQSQEA 2907
+ +C ++V+ G + +L CG+ P PV+ T S F +
Sbjct: 791 EMDI--ESQPECAYDHLEVFDG-RDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSV 847
Query: 2908 PAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYDNN----MNCTYVIEANPLSVVLLTFV 2963
+GF AS + CG ++ + DNN ++C +VI A V L F
Sbjct: 848 QRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQ 907
Query: 2964 SFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNEQ 3022
+F +E + C D + + GY + CG P + AG VL+ F+S++
Sbjct: 908 TFEVEEET----DCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDT 963
Query: 3023 ITDFGFKFSY 3032
IT GF Y
Sbjct: 964 ITKKGFHLRY 973
Score = 149 bits (377), Expect = 4e-35
Identities = 109/447 (24%), Positives = 195/447 (43%), Gaps = 75/447 (16%)
Query: 427 VNCTENINECLSNPCLNG--GTCVDGVDSFSCECTRLWTGA----LCQVPQQVCGESLSG 480
VN + ++EC S P G C++ + S+ C C + A C+ CG L+
Sbjct: 542 VNFFKEVDEC-SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA---ACGGFLTK 597
Query: 481 INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS 540
+NGS + Y + NC W + + + F FF E D C ++F++V G ++
Sbjct: 598 LNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTA 657
Query: 541 SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPEC----GGI--- 593
+ G+FCGS P + S N + S++ + +GF + + + EC GG
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQD 717
Query: 594 ---------------------------------LTGPYGSIKSPGYPGNYPPGRDCVWIV 620
+T G+I SP +P YP ++C W +
Sbjct: 718 CVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAI 777
Query: 621 VTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFA 680
++P V TF + +E +C D+LE+ DG + P+LG+FC + P+ TG
Sbjct: 778 SSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRM 837
Query: 681 RIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTR-------- 732
+ F+SD+ + +GF ++ T CGG ++ +L ++H +
Sbjct: 838 FLRFYSDNSVQRKGFQASHAT-----ECGGQV---RADVKTKDL---YSHAQFGDNNYPG 886
Query: 733 --QCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----ETLLGKVCGNGTISH 786
C +++ +G +++ F E++ ++D +Y+E+ DG LG+ CG+G
Sbjct: 887 GVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEE 946
Query: 787 IKSITNSVWIRFKIDASVEKASFRAVY 813
+ S +SV ++F D ++ K F Y
Sbjct: 947 VYSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 137 bits (344), Expect = 3e-31
Identities = 124/459 (27%), Positives = 188/459 (40%), Gaps = 88/459 (19%)
Query: 304 EDINECEI-NNGGCSVAPPVECVNTPGSSHCQACPPGYQ--GDGRVCTLTDICSVSNGGC 360
++++EC N GGC C+NT GS C +C PGY+ D R C
Sbjct: 546 KEVDECSRPNRGGCEQ----RCLNTLGSYKC-SCDPGYELAPDKRRC------------- 587
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPN-GCV-QLSNICLSHPCLNGQCIDTVSGYFC 418
+A+C L L PG+ Y PN C+ QL L +T C
Sbjct: 588 --EAACGGFLTKLNGSITSPGWPKE-YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVC 644
Query: 419 KCD-----SGWT------GVNCTENINECLSNP--------------------------- 440
K D SG T G C E +++
Sbjct: 645 KYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 704
Query: 441 --CL--NGGT---CVDGVDSFSCECTRLWTGALCQVPQQVCGES-----LSGINGSFSYR 488
C NGG CV+ S+ C+C +G + + C E+ ++ +G+ +
Sbjct: 705 DECSKDNGGCQQDCVNTFGSYECQCR---SGFVLHDNKHDCKEAGCDHKVTSTSGTITSP 761
Query: 489 SPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRF 548
+ Y C W I + G +++TF +ES C ++ L+V+DG + A LGRF
Sbjct: 762 NWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRF 821
Query: 549 CGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGG-----ILTGPYGSIKS 603
CGS P +L++ + ++ YS++ +GF T ECGG + T S
Sbjct: 822 CGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT---ECGGQVRADVKTKDLYSHAQ 878
Query: 604 PGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGK 663
G NYP G DC W++V V F T +E DC DY+E+ DG P LG+
Sbjct: 879 FG-DNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGR 937
Query: 664 FCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTS 702
+C + + + G + FHSD I+ +GFH+ Y ++
Sbjct: 938 YCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTST 976
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 216 bits (551), Expect = 3e-55
Identities = 137/386 (35%), Positives = 168/386 (43%), Gaps = 68/386 (17%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
CS N C +GGTC +L + F C+CPPQW G C D NECE C N +C N +
Sbjct: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKP-----CVNAKSCKNLIA 432
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPKYSCVCDAGWMFS 254
SY C C P G C +DC G +C + C DL+ Y C+C G+
Sbjct: 433 SYYCDCLPGWMGQNCDININDCLG----QCQNDASCRDLVNG------YRCICPPGYA-- 480
Query: 255 PNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEIN- 312
C D DEC+ PC C N F C CPTG+ GN +C+ DI+ CE N
Sbjct: 481 --GDHCERDIDECA--SNPCLNGGHCQNEINRFQC-LCPTGFSGN--LCQLDIDYCEPNP 533
Query: 313 --NGGCSVAPPVECVNTPGSSHCQACPPGYQGDG----------RVCTLTDICSV----- 355
NG +C N C+ CP Y+G C + D C+V
Sbjct: 534 CQNGA-------QCYNRASDYFCK-CPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASN 585
Query: 356 ---------SNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN 406
S+ C P C S G C C G+TG C + N C S+PC N
Sbjct: 586 DTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTY-----CHENINDCESNPCRN 640
Query: 407 G-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGA 465
G CID V+ Y C C GW G C NIN+C NPC NGGTC D V+ F C+C W G
Sbjct: 641 GGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGK 700
Query: 466 LCQVPQQVCGESLSGINGSFSYRSPD 491
C C E+ NG Y D
Sbjct: 701 TCHSRDSQCDEATCN-NGGTCYDEGD 725
Score = 167 bits (422), Expect = 2e-40
Identities = 112/371 (30%), Positives = 148/371 (39%), Gaps = 57/371 (15%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCS-----ADVNECEIYS 178
F G +D C NPCQNG C N +FC CP ++G CS CE+
Sbjct: 517 FSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVID 576
Query: 179 GTPLS-----------------CQNGGTCVNTMGS-YSCHCPPETYGPQCASKYDDCEGG 220
++ C G C + G ++C C G C +DCE
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN 636
Query: 221 SVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQC 280
G C D G Y C+C GW C + ++CS PC C
Sbjct: 637 PCRN--GGTCID------GVNSYKCICSDGW----EGAYCETNINDCS--QNPCHNGGTC 682
Query: 281 FNTQGSFYCGACPTGWQGNGYICED--INECEINNGGCSVAPPVECVNTPGSSHCQACPP 338
+ FYC C GW+G D +E NNGG C + + C CP
Sbjct: 683 RDLVNDFYCD-CKNGWKGKTCHSRDSQCDEATCNNGGT-------CYDEGDAFKCM-CPG 733
Query: 339 GYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNI 398
G++G C + S CH +C G C C G+ G C Q +N
Sbjct: 734 GWEGT--TCNIARNSSCLPNPCHNGGTCVVN-GESFTCVCKEGWEGPI-----CAQNTND 785
Query: 399 CLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCE 457
C HPC N G C+D + Y C+C G+ G +C NINEC S+PC G TCVD ++ + C
Sbjct: 786 CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCV 845
Query: 458 CTRLWTGALCQ 468
C +GA CQ
Sbjct: 846 CPPGHSGAKCQ 856
Score = 155 bits (393), Expect = 5e-37
Identities = 107/342 (31%), Positives = 145/342 (42%), Gaps = 42/342 (12%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNT-M 194
C +P G C ++ + C+C W G LC D+N C GT C NGGTC NT
Sbjct: 265 CIPHPGCVHGIC---NEPWQCLCETNWGGQLCDKDLNYC----GTHQPCLNGGTCSNTGP 317
Query: 195 GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFS 254
Y C CP GP C + C+ C + + + C C GW
Sbjct: 318 DKYQCSCPEGYSGPNCEI--------AEHACLSDPCHNRGSCKETSLGFECECSPGW--- 366
Query: 255 PNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINN 313
P C+ + D+CS P CS C + F C CP W G C+ D NECE
Sbjct: 367 -TGPTCSTNIDDCS--PNNCSHGGTCQDLVNGFKC-VCPPQWTGK--TCQLDANECEAK- 419
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C A C N S +C C PG+ G + D G C DASC +
Sbjct: 420 -PCVNAK--SCKNLIASYYCD-CLPGWMGQNCDININDCL----GQCQNDASCRDLVNGY 471
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTEN 432
C C PGY G + C + + C S+PCLN G C + ++ + C C +G++G C +
Sbjct: 472 -RCICPPGYAG-----DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD 525
Query: 433 INECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
I+ C NPC NG C + + C+C + G C + C
Sbjct: 526 IDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC 567
Score = 120 bits (301), Expect = 2e-26
Identities = 99/359 (27%), Positives = 146/359 (40%), Gaps = 68/359 (18%)
Query: 119 DLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYS 178
D + F G + C SNPC+NGGTC++ +S+ CIC W+G C ++N+C S
Sbjct: 616 DCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDC---S 672
Query: 179 GTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQ 237
P C NGGTC + + + C C G C S+ C+ A C + G C D
Sbjct: 673 QNP--CHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCD---EATCNNGGTCYD----- 722
Query: 238 AGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ 297
G+ + C+C GW C + R+ S P PC C SF C C GW+
Sbjct: 723 EGD-AFKCMCPGGW----EGTTCNIARNS-SCLPNPCHNGGTCVVNGESFTC-VCKEGWE 775
Query: 298 GNGYICEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQG-DGRVCTLTDIC 353
G C N CS P CV+ C+ C PG+ G D R+ +I
Sbjct: 776 G--------PICAQNTNDCSPHPCYNSGTCVDGDNWYRCE-CAPGFAGPDCRI----NIN 822
Query: 354 SVSNGGCHPDASCSSTLGSLPLCTCLPGYTG---NGYGPNGCVQLSNI----------CL 400
+ C A+C + C C PG++G C+ + ++ C
Sbjct: 823 ECQSSPCAFGATCVDEINGY-RCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCN 881
Query: 401 SHPCLNGQCIDTVSGYFC------------KCDSGWTGVNCTENINECLSNPCLNGGTC 447
+ CLNG+ S +C +C SG + + + ++C +PC G C
Sbjct: 882 TCQCLNGRI--ACSKVWCGPRPCLLHKGHSECPSGQSCIPILD--DQCFVHPCTGVGEC 936
Score = 110 bits (276), Expect = 2e-23
Identities = 80/247 (32%), Positives = 103/247 (41%), Gaps = 37/247 (14%)
Query: 231 EDLMREQAGEPKYSCVCDAGWMFSPNSPACT--LDRDECSFQPGPCSTLVQCFNTQGSFY 288
+D A + + C GWM P C + R CS + G C C
Sbjct: 204 DDFFGHYACDQNGNKTCMEGWM----GPECNRAICRQGCSPKHGSCKLPGDC-------- 251
Query: 289 CGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCT 348
C GWQG Y + I +G C+ C G C Y G + C
Sbjct: 252 --RCQYGWQGL-YCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDK-DLNYCGTHQPCL 307
Query: 349 LTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-G 407
NGG +CS+T C+C GY+G PN C + CLS PC N G
Sbjct: 308 --------NGG-----TCSNTGPDKYQCSCPEGYSG----PN-CEIAEHACLSDPCHNRG 349
Query: 408 QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALC 467
C +T G+ C+C GWTG C+ NI++C N C +GGTC D V+ F C C WTG C
Sbjct: 350 SCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTC 409
Query: 468 QVPQQVC 474
Q+ C
Sbjct: 410 QLDANEC 416
Score = 42.4 bits (98), Expect = 0.008
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 12/77 (15%)
Query: 418 CKCDSGWTGVNCTENINECLSNPCLNGGTCVDGV--DSFSCECTRLWTGALCQVPQQVCG 475
C+C GW G+ C ++C+ +P CV G+ + + C C W G LC CG
Sbjct: 251 CRCQYGWQGLYC----DKCIPHP-----GCVHGICNEPWQCLCETNWGGQLCDKDLNYCG 301
Query: 476 ESLSGIN-GSFSYRSPD 491
+N G+ S PD
Sbjct: 302 THQPCLNGGTCSNTGPD 318
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 210 bits (535), Expect = 2e-53
Identities = 135/408 (33%), Positives = 171/408 (41%), Gaps = 82/408 (20%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C+SNPC NGG CL S+ C CPP + GP C DVNEC P C++GGTC N +G
Sbjct: 144 CASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNEC---GQKPGLCRHGGTCHNEVG 200
Query: 196 SYSCHCPPETYGPQCASKY-----DDCEGGSVAR----------CVHGI----CEDLMRE 236
SY C C GP C Y C+ G R C+ G CE+ + +
Sbjct: 201 SYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD 260
Query: 237 QAGEP------------KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQ 284
G Y+C C W CT D DEC P C C NT
Sbjct: 261 CPGNNCKNGGACVDGVNTYNCRCPPEW----TGQYCTEDVDECQLMPNACQNGGTCHNTH 316
Query: 285 GSFYCGACPTGWQG----------------NGYICED-----INECEINNGGCSVAPPVE 323
G + C C GW G +G C D EC G
Sbjct: 317 GGYNC-VCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDA 375
Query: 324 CVNTPGS--SHCQA----------CPPGYQGDGRVCTL-TDICSVSNGGCHPDASCSSTL 370
C++ P + S+C CP GY G C+ D CS+ C C +TL
Sbjct: 376 CISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA--CSQDVDECSLGANPCEHAGKCINTL 433
Query: 371 GSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNC 429
GS C CL GYTG C N C+S+PC N C+D + + C C G+ GV+C
Sbjct: 434 GSFE-CQCLQGYTGPR-----CEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHC 487
Query: 430 TENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
N +EC S+PCL+ G C+D ++ F CEC +TG LCQ C +
Sbjct: 488 EVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAST 535
Score = 195 bits (496), Expect = 6e-49
Identities = 129/390 (33%), Positives = 169/390 (43%), Gaps = 67/390 (17%)
Query: 121 ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEI---- 176
E + G ++ C+ NPC NGGTC + + F C CP + P C ++VNEC
Sbjct: 667 EPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCV 726
Query: 177 ------------------YSGTPLS----------CQNGGTCVNTMGSYSCHCPPETYGP 208
+SGT C NGGTC + Y C C GP
Sbjct: 727 HGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGP 786
Query: 209 QCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECS 268
C + ++C G C D + AG Y C C + C + C+
Sbjct: 787 NCQTNINECASNPCLN--QGTCID---DVAG---YKCNC----LLPYTGATCEVVLAPCA 834
Query: 269 FQPGPCSTLVQCFNTQG--SFYCGACPTGWQGNGYICE-DINECEINNGGCSVAPPVECV 325
P PC +C ++ SF C CPTGWQG CE DINEC ++ C
Sbjct: 835 --PSPCRNGGECRQSEDYESFSC-VCPTGWQGQ--TCEVDINECVLS----PCRHGASCQ 885
Query: 326 NTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGN 385
NT G C C GY GR C TDI CH SC+ + + C CLPG+ G
Sbjct: 886 NTHGGYRCH-CQAGY--SGRNCE-TDIDDCRPNPCHNGGSCTDGINT-AFCDCLPGFRG- 939
Query: 386 GYGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNG 444
C + N C S PC NG C D V Y C C +G++G++C N +C + C NG
Sbjct: 940 ----TFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNG 995
Query: 445 GTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
GTCVDG++SF+C C +TG+ CQ C
Sbjct: 996 GTCVDGINSFTCLCPPGFTGSYCQHDVNEC 1025
Score = 194 bits (492), Expect = 2e-48
Identities = 116/356 (32%), Positives = 170/356 (47%), Gaps = 41/356 (11%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
++G+ V+ C+S+PC + G CL+ + F C CP + G LC DV+EC + TP
Sbjct: 482 YEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDEC---ASTP-- 536
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C+NG C++ +Y+C C G C D+C+ C +G C+D G +
Sbjct: 537 CKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDP---CHYGSCKD------GVATF 587
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYIC 303
+C+C G+ C + +ECS QP C C + ++ C C G G
Sbjct: 588 TCLCRPGY----TGHHCETNINECSSQP--CRHGGTCQDRDNAYLC-FCLKGTTGPN--- 637
Query: 304 EDINECEINNGGCSVAP--PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCH 361
CEIN C+ +P C++ C AC PGY G +C + +I + CH
Sbjct: 638 -----CEINLDDCASSPCDSGTCLDKIDGYEC-ACEPGYTGS--MCNI-NIDECAGNPCH 688
Query: 362 PDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCD 421
+C + C C GY + P C+ N C S+PC++G C D+++GY C CD
Sbjct: 689 NGGTCEDGINGFT-CRCPEGY----HDPT-CLSEVNECNSNPCVHGACRDSLNGYKCDCD 742
Query: 422 SGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
GW+G NC N NEC SNPC+NGGTC D + C C ++G CQ C +
Sbjct: 743 PGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN 798
Score = 190 bits (483), Expect = 2e-47
Identities = 119/370 (32%), Positives = 169/370 (45%), Gaps = 42/370 (11%)
Query: 113 LNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVN 172
LN D + + G ++ C SNPC NGGTC ++ + C C + GP C ++N
Sbjct: 734 LNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNIN 793
Query: 173 ECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICED 232
EC + P C N GTC++ + Y C+C G C C + + C +G
Sbjct: 794 EC---ASNP--CLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPC---APSPCRNG---G 842
Query: 233 LMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGAC 292
R+ +SCVC GW C +D +EC PC C NT G + C C
Sbjct: 843 ECRQSEDYESFSCVCPTGW----QGQTCEVDINECVL--SPCRHGASCQNTHGGYRC-HC 895
Query: 293 PTGWQGNGYICE-DINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCT 348
G+ G CE DI++C N NGG C + ++ C C PG++ G C
Sbjct: 896 QAGYSGRN--CETDIDDCRPNPCHNGG-------SCTDGINTAFCD-CLPGFR--GTFCE 943
Query: 349 LTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-G 407
DI ++ C A+C+ + S CTC G++G C + C C N G
Sbjct: 944 -EDINECASDPCRNGANCTDCVDSY-TCTCPAGFSG-----IHCENNTPDCTESSCFNGG 996
Query: 408 QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALC 467
C+D ++ + C C G+TG C ++NEC S PCL+GGTC DG S+ C C + +TG C
Sbjct: 997 TCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNC 1056
Query: 468 QVPQQVCGES 477
Q C S
Sbjct: 1057 QNLVHWCDSS 1066
Score = 190 bits (483), Expect = 2e-47
Identities = 136/435 (31%), Positives = 180/435 (41%), Gaps = 118/435 (27%)
Query: 136 CSSNPCQNGGTCLNLHD--SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNT 193
C+ +PC+NGG C D SF C+CP W+G C D+NEC + C++G +C NT
Sbjct: 833 CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSP-----CRHGASCQNT 887
Query: 194 MGSYSCHCPPETYGPQCASKYDDCE------GGSVARCVHGI---------------CED 232
G Y CHC G C + DDC GGS C GI CE+
Sbjct: 888 HGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGS---CTDGINTAFCDCLPGFRGTFCEE 944
Query: 233 LMREQAGEP------------KYSCVCDAGWM---FSPNSPACTLDRDECSFQPGPCSTL 277
+ E A +P Y+C C AG+ N+P CT + F G C
Sbjct: 945 DINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCT---ESSCFNGGTCVDG 1001
Query: 278 VQCFNTQGSFYCGACPTGWQGNGYICEDINECEIN---NGGCSVAPPVECVNTPGSSHCQ 334
+ SF C CP G+ G+ Y D+NEC+ +GG C + GS C
Sbjct: 1002 IN------SFTC-LCPPGFTGS-YCQHDVNECDSQPCLHGGT-------CQDGCGSYRC- 1045
Query: 335 ACPPGYQGDG--RVCTLTDICSVSNGG----------CH------------PDASCSSTL 370
CP GY G + D NGG C P SC
Sbjct: 1046 TCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAA 1105
Query: 371 --------------------GSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-C 409
G+ C C GYTG+ C L + C PC NG C
Sbjct: 1106 QRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY-----CEDLVDECSPSPCQNGATC 1160
Query: 410 IDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQV 469
D + GY CKC +G+ GVNC+E I+ECLS+PC NGGTC+D +++ C C R G C++
Sbjct: 1161 TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEI 1220
Query: 470 PQQVCGESLSGINGS 484
C + ++ S
Sbjct: 1221 NVDDCNPPVDPVSRS 1235
Score = 186 bits (473), Expect = 3e-46
Identities = 133/414 (32%), Positives = 186/414 (44%), Gaps = 85/414 (20%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C+S+PC +G TCL+ D + C C P + G +C+ +++EC +G P C NGGTC + +
Sbjct: 645 CASSPCDSG-TCLDKIDGYECACEPGYTGSMCNINIDEC---AGNP--CHNGGTCEDGIN 698
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
++C CP + P C S+ ++C CVHG C D + Y C CD GW
Sbjct: 699 GFTCRCPEGYHDPTCLSEVNECNSNP---CVHGACRDSLNG------YKCDCDPGW---- 745
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECE---- 310
+ C ++ +EC + PC C + + C C G+ G C+ +INEC
Sbjct: 746 SGTNCDINNNEC--ESNPCVNGGTCKDMTSGYVC-TCREGFSGPN--CQTNINECASNPC 800
Query: 311 INNGGCS----------------------VAP--PVECVN-------TPGSSHCQACPPG 339
+N G C +AP P C N S CP G
Sbjct: 801 LNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860
Query: 340 YQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNIC 399
+QG + C + DI C ASC +T G C C GY+G C + C
Sbjct: 861 WQG--QTCEV-DINECVLSPCRHGASCQNTHGGYR-CHCQAGYSGRN-----CETDIDDC 911
Query: 400 LSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
+PC NG C D ++ FC C G+ G C E+INEC S+PC NG C D VDS++C C
Sbjct: 912 RPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTC 971
Query: 459 TRLWTGALCQVPQQVCGES--------LSGINGSFSYRSPDVGYV-----HDVN 499
++G C+ C ES + GIN SF+ P G+ HDVN
Sbjct: 972 PAGFSGIHCENNTPDCTESSCFNGGTCVDGIN-SFTCLCPP-GFTGSYCQHDVN 1023
Score = 167 bits (422), Expect = 2e-40
Identities = 132/427 (30%), Positives = 177/427 (41%), Gaps = 94/427 (22%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F G+ + C+ + C NGGTC++ +SF C+CPP + G C DVNEC+
Sbjct: 975 FSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP----- 1029
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCE------------------------- 218
C +GGTC + GSY C CP GP C + C+
Sbjct: 1030 CLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGW 1089
Query: 219 -------------------GGSVAR-CVHG-ICEDLMREQAGEPKYSCVCDAGWMFSPNS 257
G VAR C HG +C D AG + C C AG+ S
Sbjct: 1090 TGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVD-----AGNTHH-CRCQAGYTGS--- 1140
Query: 258 PACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINEC---EINNG 314
C DECS P PC C + G + C C G+ G E+I+EC NG
Sbjct: 1141 -YCEDLVDECS--PSPCQNGATCTDYLGGYSC-KCVAGYHGVN-CSEEIDECLSHPCQNG 1195
Query: 315 GCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTD----ICSVSNGG-CHPDASCSST 369
G C++ P + C +CP G QG + D + VS C + +C
Sbjct: 1196 GT-------CLDLPNTYKC-SCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQ 1247
Query: 370 LGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL---NGQCIDTVSGYFCKCDSGWTG 426
+G CTC PG+ G C N CLS+PC C+ V+ + C+C +G TG
Sbjct: 1248 VGGYS-CTCPPGFVGER-----CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTG 1301
Query: 427 VNCTENINECLSNPCLNGGTCVDGVDS---FSCECTRLWTGALCQVPQQVCGESLSGING 483
C IN C PC NGGTC ++ F C+C + GA C+ + CG SL +NG
Sbjct: 1302 RRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCG-SLRCLNG 1360
Query: 484 SFSYRSP 490
P
Sbjct: 1361 GTCISGP 1367
Score = 164 bits (415), Expect = 1e-39
Identities = 114/363 (31%), Positives = 156/363 (42%), Gaps = 67/363 (18%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYS---GTPLS--CQNGGTC 190
C S+PC+NGG C H + C CP W G C CE+ + G ++ CQ+GG C
Sbjct: 1063 CDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLC 1122
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPKYSCVCDA 249
V+ ++ C C G C D+C S + C +G C D + YSC C A
Sbjct: 1123 VDAGNTHHCRCQAGYTGSYCEDLVDEC---SPSPCQNGATCTDYLGG------YSCKCVA 1173
Query: 250 GWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINEC 309
G+ + C+ + DEC P C C + ++ C +CP G QG C
Sbjct: 1174 GY----HGVNCSEEIDECLSHP--CQNGGTCLDLPNTYKC-SCPRGTQGV--------HC 1218
Query: 310 EINNGGCSVAPPVE-------------CVNTPGSSHCQACPPGY-----QGDGRVCTLTD 351
EIN C+ PPV+ CV+ G C CPPG+ +GD C L++
Sbjct: 1219 EINVDDCN--PPVDPVSRSPKCFNNGTCVDQVGGYSC-TCPPGFVGERCEGDVNEC-LSN 1274
Query: 352 ICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCI- 410
C +C + C C G+TG C + N C PC NG
Sbjct: 1275 PCDARG-----TQNCVQRVNDFH-CECRAGHTGRR-----CESVINGCKGKPCKNGGTCA 1323
Query: 411 ---DTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALC 467
+T G+ CKC +G+ G C + C S CLNGGTC+ G S +C C +TG C
Sbjct: 1324 VASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPEC 1383
Query: 468 QVP 470
Q P
Sbjct: 1384 QFP 1386
Score = 151 bits (382), Expect = 1e-35
Identities = 111/348 (31%), Positives = 148/348 (42%), Gaps = 44/348 (12%)
Query: 132 DKKVCSSNPCQNGGTCLNLHD----SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNG 187
D C S PC+N GTC + + C C + GPLC ++ + + C+NG
Sbjct: 59 DPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTN----PCRNG 114
Query: 188 GTC-VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCV 246
GTC + T+ Y C CPP G C + D C A G C E Y C
Sbjct: 115 GTCDLLTLTEYKCRCPPGWSGKSC-QQADPCASNPCAN--GGQCLPF------EASYICH 165
Query: 247 CDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDI 306
C + + P C D +EC +PG C C N GS+ C T N
Sbjct: 166 CPPSF----HGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPN------- 214
Query: 307 NECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPD 363
CE CS +P C T +H AC PG+ G + D C +N C
Sbjct: 215 --CERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD-CPGNN--CKNG 269
Query: 364 ASCSSTLGSLPLCTCLPGYTGN--GYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCD 421
+C + + C C P +TG + C + N C + G C +T GY C C
Sbjct: 270 GACVDGVNTYN-CRCPPEWTGQYCTEDVDECQLMPNACQN----GGTCHNTHGGYNCVCV 324
Query: 422 SGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQV 469
+GWTG +C+ENI++C S C +G TC D V SF CEC TG LC +
Sbjct: 325 NGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHL 372
Score = 143 bits (361), Expect = 3e-33
Identities = 111/342 (32%), Positives = 149/342 (43%), Gaps = 55/342 (16%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC--VNTMG--S 196
C NGG C + + C+C + GP C D N C TP C+N GTC V+ G
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPC---LSTP--CKNAGTCHVVDRRGVAD 84
Query: 197 YSCHCPPETYGPQCASKYDD------CEGGSVARCVHGICEDLMREQAGEPKYSCVCDAG 250
Y+C C GP C + D+ C G G C+ L + Y C C G
Sbjct: 85 YACSCALGFSGPLCLTPLDNACLTNPCRNG-------GTCDLLTLTE-----YKCRCPPG 132
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYIC-EDINEC 309
W + +C D C+ PC+ QC + S+ C CP + +G C +D+NEC
Sbjct: 133 W----SGKSCQ-QADPCA--SNPCANGGQCLPFEASYIC-HCPPSF--HGPTCRQDVNEC 182
Query: 310 EINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDI-CSVSNGGCHPDASCSS 368
G C C N GS C C + G C + CS S C +C
Sbjct: 183 GQKPGLCRHGG--TCHNEVGSYRC-VCRATHTGPN--CERPYVPCSPS--PCQNGGTCRP 235
Query: 369 TLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGV 427
T C CLPG+TG C + + C + C N G C+D V+ Y C+C WTG
Sbjct: 236 TGDVTHECACLPGFTG-----QNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQ 290
Query: 428 NCTENINEC--LSNPCLNGGTCVDGVDSFSCECTRLWTGALC 467
CTE+++EC + N C NGGTC + ++C C WTG C
Sbjct: 291 YCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332
Score = 125 bits (314), Expect = 8e-28
Identities = 93/298 (31%), Positives = 124/298 (41%), Gaps = 34/298 (11%)
Query: 183 SCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
+C NGG C G+ +C C GP+C + C G C + ++ G
Sbjct: 30 TCLNGGKCEAANGTEACVCGGAFVGPRCQDP-NPCLSTPCKNA--GTCH--VVDRRGVAD 84
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
Y+C C G+ + P C D PC C + Y CP GW G
Sbjct: 85 YACSCALGF----SGPLCLTPLDNACL-TNPCRNGGTCDLLTLTEYKCRCPPGWSGKS-- 137
Query: 303 CEDINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTL-TDICSVSNG 358
C+ + C N NGG +C+ S C CPP + G C + C G
Sbjct: 138 CQQADPCASNPCANGG-------QCLPFEASYICH-CPPSFHGP--TCRQDVNECGQKPG 187
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVS-GY 416
C +C + +GS C C +T GPN C + C PC N G C T +
Sbjct: 188 LCRHGGTCHNEVGSY-RCVCRATHT----GPN-CERPYVPCSPSPCQNGGTCRPTGDVTH 241
Query: 417 FCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
C C G+TG NC ENI++C N C NGG CVDGV++++C C WTG C C
Sbjct: 242 ECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDEC 299
Score = 106 bits (264), Expect = 5e-22
Identities = 110/409 (26%), Positives = 151/409 (36%), Gaps = 99/409 (24%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
CS +PCQNG TC + + C C + G CS +++EC + CQNGGTC++
Sbjct: 1149 CSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHP-----CQNGGTCLDLPN 1203
Query: 196 SYSCHCPPETYGPQCASKYDDCEG-----GSVARCVH-GICEDLMREQAGEPKYSCVCDA 249
+Y C CP T G C DDC +C + G C D Q G YSC C
Sbjct: 1204 TYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVD----QVGG--YSCTCPP 1257
Query: 250 GWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICED-INE 308
G++ C D +EC P C F+C C G G CE IN
Sbjct: 1258 GFV----GERCEGDVNECLSNPCDARGTQNCVQRVNDFHC-ECRAGHTGRR--CESVING 1310
Query: 309 CE----INNGGCSVAPPVECVNTPGSSHCQACPPGYQG-----DGRVC------------ 347
C+ N G C+VA NT C+ CP G++G D R C
Sbjct: 1311 CKGKPCKNGGTCAVAS-----NTARGFICK-CPAGFEGATCENDARTCGSLRCLNGGTCI 1364
Query: 348 ----TLTDIC--------------SVSNGG--CHPDASCSSTLGSLPLCTCLPGYTGNG- 386
+ T +C S GG C+ +C T S P CL NG
Sbjct: 1365 SGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSES-PFYRCLCPAKFNGL 1423
Query: 387 --------YGPNGCVQLSNICLSHPCLNGQCIDTVSGYFC--KCDS---GWTGVNCTENI 433
+G + + C +C + C +C++ GW G +C+ N
Sbjct: 1424 LCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNF 1483
Query: 434 NECLSN--------PCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
N+ N + G C +S C L+ G CQ + C
Sbjct: 1484 NDPWKNCTQSLQCWKYFSDGHCDSQCNSAGC----LFDGFDCQRAEGQC 1528
Score = 84.7 bits (208), Expect = 1e-15
Identities = 97/422 (22%), Positives = 146/422 (34%), Gaps = 92/422 (21%)
Query: 76 EDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKV 135
E++ ECL +N G+ + LP + ++ V E VD V
Sbjct: 1182 EEIDECLSHPCQNG-------GTCLDLPNTYKCSCPR-GTQGVHCEINVDDCNPPVDP-V 1232
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
S C N GTC++ + C CPP + G C DVNEC P + CV +
Sbjct: 1233 SRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNEC---LSNPCDARGTQNCVQRVN 1289
Query: 196 SYSCHCPPETYGPQCASKYDDCEG-----------------GSVARCVHGI----CEDLM 234
+ C C G +C S + C+G G + +C G CE+
Sbjct: 1290 DFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDA 1349
Query: 235 REQAGEPKYSCVCDAGWMFSPNSPAC----TLDRDECSF-QPGPCSTLVQCFN------- 282
R C+ + P SP C EC F PC C+N
Sbjct: 1350 RTCG---SLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPT 1406
Query: 283 TQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPV--------ECVNTPGSSHCQ 334
++ FY CP + NG +C ++ G + PP+ EC G+ C
Sbjct: 1407 SESPFYRCLCPAKF--NGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCS 1464
Query: 335 A-------------CPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPG 381
C + + CT + C H D+ C+S G
Sbjct: 1465 LQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSA-----------G 1513
Query: 382 YTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCK--CDSG---WTGVNCTENINEC 436
+G+ C + C +P + C D S C C+S W G++C E++ E
Sbjct: 1514 CLFDGF---DCQRAEGQC--NPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPER 1568
Query: 437 LS 438
L+
Sbjct: 1569 LA 1570
Score = 83.6 bits (205), Expect = 3e-15
Identities = 57/191 (29%), Positives = 75/191 (39%), Gaps = 19/191 (9%)
Query: 289 CGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCT 348
C A G C E +N G C A E G+ C C
Sbjct: 10 CLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCK 69
Query: 349 LTDICSVSNGGCHPDASCSSTLG-SLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG 407
C V + D +CS LG S PLC L N CL++PC NG
Sbjct: 70 NAGTCHVVDRRGVADYACSCALGFSGPLCL---------------TPLDNACLTNPCRNG 114
Query: 408 QCID--TVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGA 465
D T++ Y C+C GW+G +C + + C SNPC NGG C+ S+ C C + G
Sbjct: 115 GTCDLLTLTEYKCRCPPGWSGKSC-QQADPCASNPCANGGQCLPFEASYICHCPPSFHGP 173
Query: 466 LCQVPQQVCGE 476
C+ CG+
Sbjct: 174 TCRQDVNECGQ 184
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 209 bits (532), Expect = 4e-53
Identities = 135/370 (36%), Positives = 173/370 (46%), Gaps = 48/370 (12%)
Query: 124 FQGLQQTVDKKVCS-SNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPL 182
+QG D C PC++GGTCLN SF C CP + GPLC C P
Sbjct: 150 YQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC-----APS 204
Query: 183 SCQNGGTCVNTMG-SYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGE 240
C+NGGTC + +Y C C P G C DDC G RC++ G C D G
Sbjct: 205 PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG---HRCLNGGTCVD------GV 255
Query: 241 PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG 300
Y+C C W CT D DEC QP C CFNT G C C GW G
Sbjct: 256 NTYNCQCPPEW----TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSC-VCVNGWTG-- 308
Query: 301 YICEDINECEINNGGCSVA---PPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSN 357
C N C+ A C + S +C ACP G G +C L D C VSN
Sbjct: 309 ------ESCSQNIDDCATAVCFHGATCHDRVASFYC-ACPMG--KTGLLCHLDDAC-VSN 358
Query: 358 GGCHPDASC-SSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICL--SHPCLN-GQCIDTV 413
CH DA C ++ + +CTC PG+TG C Q + C ++PC + G+C++T
Sbjct: 359 -PCHEDAICDTNPVNGRAICTCPPGFTG-----GACDQDVDECSIGANPCEHLGRCVNTQ 412
Query: 414 SGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQV 473
+ C+C G+TG C ++NECLS PC N TC+D + F+C C +TG C+V
Sbjct: 413 GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDE 472
Query: 474 CGESLSGING 483
C +S +NG
Sbjct: 473 C-QSSPCVNG 481
Score = 207 bits (527), Expect = 2e-52
Identities = 148/459 (32%), Positives = 192/459 (41%), Gaps = 113/459 (24%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F+G V+ C + C NGGTC++ +++ C CPP+W G C+ DV+EC++ P +
Sbjct: 228 FEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQL---QPNA 284
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMRE-----Q 237
C NGGTC NT+G +SC C G C+ DDC + A C HG C D +
Sbjct: 285 CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDC---ATAVCFHGATCHDRVASFYCACP 341
Query: 238 AGEPKYSCVCDAGWMFSP------------------------NSPACTLDRDECSFQPGP 273
G+ C D + +P AC D DECS P
Sbjct: 342 MGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANP 401
Query: 274 CSTLVQCFNTQGSFYCGACPTGWQG----------------------------------- 298
C L +C NTQGSF C C G+ G
Sbjct: 402 CEHLGRCVNTQGSFLC-QCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAG 460
Query: 299 -NGYICE-DINECE----INNGGC-------SVAPPV------------ECVNTP--GSS 331
G CE DI+EC+ +N G C S P EC +TP +
Sbjct: 461 FTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGA 520
Query: 332 HCQACPPGYQ---GDGRVCTLTD--ICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNG 386
C P GY+ +G TL D + S CH C + S C C PGYTG
Sbjct: 521 KCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH-HGRCVDGIASFS-CACAPGYTG-- 576
Query: 387 YGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGG 445
C + C S PC + G+C+D V Y C+C SG TGVNC NI++C SNPC G
Sbjct: 577 ---TRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFG 632
Query: 446 TCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGS 484
C DG++ + C C +TG LC V C S G GS
Sbjct: 633 VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGS 671
Score = 196 bits (497), Expect = 5e-49
Identities = 133/413 (32%), Positives = 181/413 (43%), Gaps = 80/413 (19%)
Query: 108 SQIYQLNSKLVDLERKF--------QGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICP 159
SQ + K +DL K+ G+ V+ C+SNPC G C + + + C+C
Sbjct: 588 SQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQ 646
Query: 160 PQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEG 219
P + GPLC+ ++NEC + +P C GG+CV+ + C CPP + P C C
Sbjct: 647 PGFTGPLCNVEINEC---ASSP--CGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC-- 699
Query: 220 GSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACT--LDRDECSFQP------ 271
+ C HGIC D + CVC+ GW + P C+ L RD C QP
Sbjct: 700 -AHEPCSHGICYD------APGGFRCVCEPGW----SGPRCSQSLARDACESQPCRAGGT 748
Query: 272 -----------------------------GPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
PC +C + G +CP GWQG
Sbjct: 749 CSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPR-- 806
Query: 303 CE-DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCH 361
C+ D++EC G P C N GS C C GY G C DI C
Sbjct: 807 CQQDVDECA---GPAPCGPHGICTNLAGSFSC-TCHGGYTGPS--CD-QDINDCDPNPCL 859
Query: 362 PDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCD 421
SC +GS C+CLPG+ G C + + CLS+PC G C D V+ + C C
Sbjct: 860 NGGSCQDGVGSFS-CSCLPGFAGPR-----CARDVDECLSNPCGPGTCTDHVASFTCTCP 913
Query: 422 SGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
G+ G +C +++ +C + C NGGTCVDGV+SFSC C +TGA CQ C
Sbjct: 914 PGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966
Score = 167 bits (422), Expect = 2e-40
Identities = 116/389 (29%), Positives = 164/389 (42%), Gaps = 72/389 (18%)
Query: 128 QQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNG 187
QQ VD+ PC G C NL SF C C + GP C D+N+C+ P C NG
Sbjct: 808 QQDVDE-CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD-----PNPCLNG 861
Query: 188 GTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVC 247
G+C + +GS+SC C P GP+CA D+C C G C D + ++C C
Sbjct: 862 GSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP---CGPGTCTDHVAS------FTCTC 912
Query: 248 DAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDIN 307
G+ C D +CS P C C + SF C C G+ G + + +
Sbjct: 913 PPGY----GGFHCEQDLPDCS--PSSCFNGGTCVDGVNSFSC-LCRPGYTG-AHCQHEAD 964
Query: 308 ECE----INNGGCSVAPP---VECVNTPGSSHCQA------------------------C 336
C ++ G CS A P C+ + CQ C
Sbjct: 965 PCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLC 1024
Query: 337 PPGYQGDGRVCTLTDI-CSVSNGG--------CHPDASCSSTLGSLPLCTCLPGYTGNGY 387
PPG+ G R+C + + C + C C S C C G TG+
Sbjct: 1025 PPGWSG--RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDE-DSSHYCVCPEGRTGSH- 1080
Query: 388 GPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGT 446
C Q + CL+ PC +G C + GY C+C G+ G NC ++++EC S PC +GG+
Sbjct: 1081 ----CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGS 1136
Query: 447 CVDGVDSFSCECTRLWTGALCQVPQQVCG 475
C+D V + C C G LC++ + CG
Sbjct: 1137 CIDLVARYLCSCPPGTLGVLCEINEDDCG 1165
Score = 159 bits (403), Expect = 4e-38
Identities = 122/398 (30%), Positives = 161/398 (40%), Gaps = 85/398 (21%)
Query: 136 CSSNPCQNGGTCLNLHDSF-FCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTM 194
C+ NPC++GG C + C CP W+GP C DV+EC P C G C N
Sbjct: 775 CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDEC----AGPAPCGPHGICTNLA 830
Query: 195 GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCDAGWMF 253
GS+SC C GP C +DC+ C++G C+D G +SC C G+
Sbjct: 831 GSFSCTCHGGYTGPSCDQDINDCDPNP---CLNGGSCQD------GVGSFSCSCLPGFA- 880
Query: 254 SPNSPACTLDRDECSFQP-GPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEI 311
P C D DEC P GP + C + SF C CP G+ G+ CE D+ +C
Sbjct: 881 ---GPRCARDVDECLSNPCGPGT----CTDHVASFTC-TCPPGY--GGFHCEQDLPDCSP 930
Query: 312 N---NGGCSVAPPVECVNTPGSSHCQACPPGYQGD----------GRVCTLTDICSVSNG 358
+ NGG CV+ S C C PGY G R C +CS +
Sbjct: 931 SSCFNGGT-------CVDGVNSFSC-LCRPGYTGAHCQHEADPCLSRPCLHGGVCSAA-- 980
Query: 359 GCHPDASCSSTLGSL-PLCTCLPGYTGNGYGPNG--CVQLSNICL-------------SH 402
HP C+ P C L + NG CVQ CL S
Sbjct: 981 --HPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL 1038
Query: 403 PC----------------LNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGT 446
PC GQC+D S ++C C G TG +C + ++ CL+ PC +GGT
Sbjct: 1039 PCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGT 1098
Query: 447 CVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGS 484
C + + CEC + G C+ C GS
Sbjct: 1099 CRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGS 1136
Score = 150 bits (380), Expect = 2e-35
Identities = 109/387 (28%), Positives = 157/387 (40%), Gaps = 61/387 (15%)
Query: 115 SKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNEC 174
S L R + G + D C S PC+N TCL+ F CIC + G C D++EC
Sbjct: 414 SFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC 473
Query: 175 EIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEG--------------G 220
+ +P C NGG C + + +SC CP G C D+C G
Sbjct: 474 Q---SSP--CVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG 528
Query: 221 SVARCVHG----ICEDLMREQAGEP-----------KYSCVCDAGWMFSPNSPACTLDRD 265
RC G +C+ + + + +P +SC C G+ C D
Sbjct: 529 YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGY----TGTRCESQVD 584
Query: 266 ECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECV 325
EC Q PC +C + + C CP+G G +N CE+N C+ P V
Sbjct: 585 ECRSQ--PCRHGGKCLDLVDKYLC-RCPSGTTG-------VN-CEVNIDDCASNPCTFGV 633
Query: 326 NTPGSSHCQ-ACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTG 384
G + C PG+ G +C + +I ++ C SC C C PG
Sbjct: 634 CRDGINRYDCVCQPGFTGP--LCNV-EINECASSPCGEGGSCVDGENGF-RCLCPPGSL- 688
Query: 385 NGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENI--NECLSNPCL 442
P C+ S+ C PC +G C D G+ C C+ GW+G C++++ + C S PC
Sbjct: 689 ----PPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCR 744
Query: 443 NGGTCVDGVDSFSCECTRLWTGALCQV 469
GGTC F C C G C++
Sbjct: 745 AGGTCSSDGMGFHCTCPPGVQGRQCEL 771
Score = 149 bits (376), Expect = 5e-35
Identities = 129/429 (30%), Positives = 163/429 (37%), Gaps = 98/429 (22%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F G + D C SNPC GTC + SF C CPP + G C D+ +C +P S
Sbjct: 879 FAGPRCARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDC-----SPSS 932
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPK 242
C NGGTCV+ + S+SC C P G C + D C C+HG +C A P
Sbjct: 933 CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRP---CLHGGVCS------AAHPG 983
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
+ C C + S P C D CS QP C +C T YC CP GW G +
Sbjct: 984 FRCTC----LESFTGPQCQTLVDWCSRQP--CQNGGRCVQTGA--YC-LCPPGWSGR--L 1032
Query: 303 CEDINECEINNGGCSVAPPVE--------CVNTPGSSHCQACPPGYQGDGRVCTL-TDIC 353
C DI + +E CV+ S +C CP G G C D C
Sbjct: 1033 C-DIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYC-VCPEGRTGSH--CEQEVDPC 1088
Query: 354 SVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL-------- 405
C +C +G +C CLPGY G+ C + C S PC
Sbjct: 1089 LAQP--CQHGGTCRGYMGGY-MCECLPGYNGDN-----CEDDVDECASQPCQHGGSCIDL 1140
Query: 406 --------------------------------------NGQCIDTVSGYFCKCDSGWTGV 427
NG C+D V G+ C C G+TG+
Sbjct: 1141 VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL 1200
Query: 428 NCTENINECLSNPCLNGGT--CV-DGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGS 484
C +INEC S C T C+ D F C C ++G CQ C ES +G
Sbjct: 1201 RCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPC-ESQPCQHGG 1259
Query: 485 FSYRSPDVG 493
SP G
Sbjct: 1260 QCRPSPGPG 1268
Score = 148 bits (373), Expect = 1e-34
Identities = 118/393 (30%), Positives = 153/393 (38%), Gaps = 79/393 (20%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLC---SADVNECEIYSGTPLS--CQNGGTC 190
CS PCQNGG C+ +C+CPP W G LC S E G L CQ GG C
Sbjct: 1004 CSRQPCQNGGRCVQT--GAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDC--------------EGGSVARCVHGI----CED 232
V+ S+ C CP G C + D C GG + C+ G CED
Sbjct: 1062 VDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCED 1121
Query: 233 LMREQAGEP------------KYSCVCDAGWMFSPNSPACTLDRDECSFQPGP------- 273
+ E A +P +Y C C G + C ++ D+C PGP
Sbjct: 1122 DVDECASQPCQHGGSCIDLVARYLCSCPPGTL----GVLCEINEDDCG--PGPPLDSGPR 1175
Query: 274 CSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINNGGCSVAPPVECVNTPGSSH 332
C C + G F C CP G+ G CE DINEC +G C A +C+ PG
Sbjct: 1176 CLHNGTCVDLVGGFRC-TCPPGY--TGLRCEADINECR--SGACHAAHTRDCLQDPGGGF 1230
Query: 333 CQACPPGYQGDGRVCTLTDICSVS----NGGCHPDASCSSTLGSLPLCTCLPGYTGNGYG 388
C G+ G R T+ C G C P G C C + +G
Sbjct: 1231 RCLCHAGFSGP-RCQTVLSPCESQPCQHGGQCRPSPGPGG--GLTFTCHCAQPF----WG 1283
Query: 389 PNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTE--------NINECLSN 439
P C +++ C C G C T G C C G +G +C + C +
Sbjct: 1284 PR-CERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAA 1342
Query: 440 PCLNGGTCVDG--VDSFSCECTRLWTGALCQVP 470
PCL+GG+C F C C + WTG C+ P
Sbjct: 1343 PCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAP 1375
Score = 118 bits (296), Expect = 9e-26
Identities = 95/300 (31%), Positives = 122/300 (40%), Gaps = 71/300 (23%)
Query: 179 GTPLSCQNGGTCVNTMG-SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQ 237
G+P C NGG C +C CPP G +C + D C G A G+C+ +
Sbjct: 46 GSP--CANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAG--RGVCQSSV--V 98
Query: 238 AGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ 297
AG ++SC C G+ P C+L P PC + C G +
Sbjct: 99 AGTARFSCRCPRGF----RGPDCSL--------PDPCLS-------------SPCAHGAR 133
Query: 298 GNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTL-TDICSVS 356
CSV P G C +CPPGYQG R C D C V
Sbjct: 134 ------------------CSVGPD-------GRFLC-SCPPGYQG--RSCRSDVDECRVG 165
Query: 357 NGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSG- 415
C +C +T GS C C GYTG C + C PC NG
Sbjct: 166 EP-CRHGGTCLNTPGSFR-CQCPAGYTGPL-----CENPAVPCAPSPCRNGGTCRQSGDL 218
Query: 416 -YFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
Y C C G+ G NC N+++C + CLNGGTCVDGV++++C+C WTG C C
Sbjct: 219 TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278
Score = 63.2 bits (152), Expect = 5e-09
Identities = 71/281 (25%), Positives = 85/281 (30%), Gaps = 46/281 (16%)
Query: 136 CSSNPCQNGGTCLNLHD-----SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
C S PCQ+GG C +F C C + GP C C L C G C
Sbjct: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCR-----ELQCPVGVPC 1304
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGIC--EDLMREQAGEPKYSCVCD 248
T C CPP GP C S G S A C C R P + C C
Sbjct: 1305 QQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACA 1364
Query: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQG----SFYCGACPTGWQGNG---Y 301
GW P C P C +G C + GW G
Sbjct: 1365 QGW----TGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS 1420
Query: 302 ICEDINECE-------INNGGCSVA-PPVECVNTPGSSHC----QACPPGYQ-------G 342
+ + +CE NN C A C+ H + C P Y+
Sbjct: 1421 VGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFA 1480
Query: 343 DGRV---CTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLP 380
DGR C T+ C C + G L L LP
Sbjct: 1481 DGRCDQGCN-TEECGWDGLDCASEVPALLARGVLVLTVLLP 1520
Score = 44.7 bits (104), Expect = 0.002
Identities = 42/185 (22%), Positives = 62/185 (33%), Gaps = 46/185 (24%)
Query: 122 RKFQGLQQTVDKKVCSSNPCQNGGTC--LNLHDSFFCICPPQWKGPLCSA-----DVNE- 173
R F G C++ PC +GG+C L F C C W GP C A +V+E
Sbjct: 1325 RSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEE 1384
Query: 174 ----------------CEIYSGTPLSCQNGGTCVNTMGS--------------YSCHCPP 203
C+ +P +GG C ++G + C P
Sbjct: 1385 PRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDP 1444
Query: 204 ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLD 263
P C DC G R + + E + + + CD G N+ C D
Sbjct: 1445 ACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGR----CDQGC----NTEECGWD 1496
Query: 264 RDECS 268
+C+
Sbjct: 1497 GLDCA 1501
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 208 bits (529), Expect = 9e-53
Identities = 125/363 (34%), Positives = 179/363 (49%), Gaps = 12/363 (3%)
Query: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
CGG LS +G+FSSP FP YP N EC W I GSS+ LT H FD+EYH C+FD LE
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
IY G + + P P +S+ + +++ F +D + GF+A +Q C
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPF--TSSWHVMSVIFHSDKHVASHGFSAGYQKDV--C 145
Query: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGL 1570
GG+ SG + SP YP+ Y ++ +C WVIR V L F DF +E + C Y +
Sbjct: 146 GGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAV 205
Query: 1571 --SSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHILTSS 1628
+R CG + +VS G+ L + F+S + RGF+A + + +
Sbjct: 206 LGGPGPTRGHHYCGSTR-PPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
Query: 1629 FDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELER----STTCARDFVEILD 1684
SSP++P++YPNN C W I+ PP + + F +LE + TC D + D
Sbjct: 265 RGNFSSPQYPSSYPNNIRCHWTIRL-PPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFD 323
Query: 1685 GGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYM 1744
G E+APL G +CG +P P+TS + L L +D S + GF CG
Sbjct: 324 GASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTE 383
Query: 1745 AEG 1747
EG
Sbjct: 384 GEG 386
Score = 204 bits (518), Expect = 2e-51
Identities = 125/378 (33%), Positives = 185/378 (48%), Gaps = 17/378 (4%)
Query: 810 RAVYQVACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAH 868
+A+ V CG L+ G SP FP +YP C W I + +LL F F++
Sbjct: 23 QAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDT 82
Query: 869 CETDYVEIGSSSILGSPENK----KYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
C D++EI + + SP+ ++CG P TS ++ + V F +HGF A
Sbjct: 83 CSFDFLEIYNGA---SPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAG 139
Query: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
+ + CG +LT +G + SP +PN YP+ + C W I + L+F F +E +
Sbjct: 140 YQKD--VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEE 197
Query: 985 CTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISA 1044
CT DY+ V T YCG + PP+L S G+ L +VF +D ++ GF +A
Sbjct: 198 CTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGF----KAYYF 253
Query: 1045 ATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT 1104
+ C + Y G F+SP +P++YPNN C + I + G + V F + LEE T
Sbjct: 254 SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
Query: 1105 ---DFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGS 1161
D L DG E++PLLG + G +LPP + S N+L L +D+ TR GFS + G
Sbjct: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
Query: 1162 STGCGGNLTTSSGTFISP 1179
GCG T G + P
Sbjct: 374 QLGCGSGSTEGEGEALQP 391
Score = 200 bits (509), Expect = 2e-50
Identities = 122/363 (33%), Positives = 177/363 (48%), Gaps = 22/363 (6%)
Query: 1267 GRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD 1326
G G +A+ + + +++ G S +P Y N C+W I G++V TF AFD
Sbjct: 17 GPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFD 76
Query: 1327 LEHHINCSTDYLELYDGPRQ-----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKG 1381
LE+H CS D+LE+Y+G +GR+CG +PPP T+S + ++ G
Sbjct: 77 LEYHDTCSFDFLEIYNGASPDKGNLLGRFCG-KVPPPPFTSSWHVMSVIFHSDKHVASHG 135
Query: 1382 FQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYH 1441
F + CGG L+G +G +SP +PN YP + EC W IR + ++L DF VE +
Sbjct: 136 FSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGN 195
Query: 1442 SRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNA 1501
C +D + + GGP R C P + S G+EL + FK+D +I GRGF A
Sbjct: 196 EECTYDYVAVLGGPG--PTRGHHYC---GSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
Query: 1502 SWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQD 1561
+ +G C ++ A G SP YPS Y +N C W IR+ ++V + F D DLE +
Sbjct: 251 YY--FSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPN 308
Query: 1562 SC--------IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFR 1613
S + A+DG S L CG L P+ SS N L L + S RGF
Sbjct: 309 SLTKTCDFDHLAAFDGASEEAPLLGNWCG-HHLPPPVTSSHNQLLLLLHTDRSTTRRGFS 367
Query: 1614 AQF 1616
+
Sbjct: 368 VAY 370
Score = 199 bits (505), Expect = 5e-50
Identities = 122/368 (33%), Positives = 179/368 (48%), Gaps = 14/368 (3%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CGG L+ SG F SPN+P Y +++EC W + + GS+ L F F LE+H C+ D+L
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 1225 VYDGPS-SNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVI 1283
+Y+G S +LL + CG PP SS M + +D+ GF A Y++ V+
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
Query: 1284 VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELY-- 1341
+ G+L S YPN Y + C+W IRA V F+ F +E + C+ DY+ +
Sbjct: 150 TGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG 208
Query: 1342 DGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTD-GVGRREKGFQMQWFVYGCGGELSGATG 1400
GP + YCG PP + +LQV+ +D +G R GF+ +F C G
Sbjct: 209 PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGR--GFKAYYFSGECQEVYMAMRG 266
Query: 1401 SFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE----YHSRCNFDVLEIYGGPD 1456
+FSSP +P+ YP N C W IR PG +++ D D+E C+FD L + G
Sbjct: 267 NFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGAS 326
Query: 1457 FHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQA 1516
+P + C P V+S+ N+L + TD S RGF+ ++ GCG
Sbjct: 327 EEAPLLGNWCGHHLPP---PVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTE 383
Query: 1517 PSGEIHSP 1524
GE P
Sbjct: 384 GEGEALQP 391
Score = 182 bits (463), Expect = 4e-45
Identities = 125/392 (31%), Positives = 184/392 (46%), Gaps = 23/392 (5%)
Query: 2919 RCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCV 2978
+CG + PSG SPN+P+ Y N C+++I S VLLTF +F LE +C
Sbjct: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHD----TCS 84
Query: 2979 NDGVHIIRGYSV-MSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIIS 3036
D + I G S CG P P T + V+ + F+S++ + GF Y+
Sbjct: 85 FDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV 144
Query: 3037 CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYL 3096
CGGV SG++TSP Y +YPN M C + I + ++L F DF V + C++DY+
Sbjct: 145 CGGVLTGLSGVLTSPEYP-NNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
Query: 3097 AIYDGANTSDPLLG-KFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQ 3155
A+ G P G +CGS RPP + S + + +VFK+D +G+K +
Sbjct: 204 AVLGGPG---PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF-----SG 255
Query: 3156 GCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAA-STRQR 3214
C F+SP S+ Y N+ C W I P + + F LE S +
Sbjct: 256 ECQEVYMAMRGNFSSPQYPSS--YPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
Query: 3215 CLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIM 3274
C +D++ +DG SE A L G +CG +P P SS N L + +D + R GF+ Y
Sbjct: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
Query: 3275 DMPCGG----TYNATWTPQNISSPNSSDPDVP 3302
+ CG PQ++ SP+S P P
Sbjct: 374 QLGCGSGSTEGEGEALQPQSLQSPSSIPPVCP 405
Score = 181 bits (458), Expect = 2e-44
Identities = 122/376 (32%), Positives = 180/376 (47%), Gaps = 19/376 (5%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
CGG+ + +G SP++P+ +P N+ CSW + + + ++F + F + D C F
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF-HAFDLEYHD-TCSFDF 87
Query: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASFVSR-CGS 2922
++++ G LL CG V P P + + + +F S + A GFSA + CG
Sbjct: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
Query: 2923 NFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGV 2982
TG SG + SP YP Y N+M C +VI A + V L FV F +E C D V
Sbjct: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNE----ECTYDYV 203
Query: 2983 HIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCGGVF 3041
++ G T CG P L G L + F S+ I GFK Y C V+
Sbjct: 204 AVLGGPG--PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVY 261
Query: 3042 NFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTS----CSHDYLA 3097
G +SP Y + YPN++ C +TI + +++ F D D+ S C D+LA
Sbjct: 262 MAMRGNFSSPQYP-SSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
Query: 3098 IYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGC 3157
+DGA+ PLLG +CG PP V SS+N +LL+ TD T +G+ +++ +G Q GC
Sbjct: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY---IGGQLGC 377
Query: 3158 GGYLTGSNNTFASPDS 3173
G T P S
Sbjct: 378 GSGSTEGEGEALQPQS 393
Score = 175 bits (443), Expect = 8e-43
Identities = 118/372 (31%), Positives = 174/372 (46%), Gaps = 29/372 (7%)
Query: 1738 CGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVE 1797
CGG G F+SP +P +YP N EC W IV + G+ + L+F +F LE CS DF+E
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 1798 IREGNA--TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDN 1855
I G + G+L+GR+CG P ++S H + V F SD + GF A + K
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTS-SWHVMSVIFHSDKHVASHGFSAGYQKDVCGGV 148
Query: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
+ G G + SP +P NYP++ W + V ++ +E + C YD + + G
Sbjct: 149 LTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG 208
Query: 1916 PSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIA 1974
P YCG T+ + S G+ L F SD +I G+GF +F+ G +
Sbjct: 209 PG--PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS-----GECQEVY 261
Query: 1975 PGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDS-TVELNILSLDIES----H 2029
G F SP +P SY N + C W I+ P V++ L LD+E
Sbjct: 262 MAMRGNF----------SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLT 311
Query: 2030 RTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH 2089
+TC +D L DG + A L CG +P P+ S+ + + +D S TR GF+ ++
Sbjct: 312 KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY- 370
Query: 2090 KSCGGYLHADRG 2101
GG L G
Sbjct: 371 --IGGQLGCGSG 380
Score = 171 bits (433), Expect = 1e-41
Identities = 119/381 (31%), Positives = 175/381 (45%), Gaps = 27/381 (7%)
Query: 2566 EDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESH 2625
E CGG L + P GNF+SP + R Y N C W + SS+ + F F LE H
Sbjct: 26 EGVKCGGVL-SAPSGNFSSPNFP--RLYPYNTECSWLIVVAE--GSSVLLTFHAFDLEYH 80
Query: 2626 QDCQFDVLEFRVGDAD--GPLMWRLCGPSKPTLPLVIPYSQVW----IHFVTNERVEHIG 2679
C FD LE G + G L+ R CG P P++ W + F +++ V G
Sbjct: 81 DTCSFDFLEIYNGASPDKGNLLGRFCGKVPPP-----PFTSSWHVMSVIFHSDKHVASHG 135
Query: 2680 FHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPH 2739
F A Y CGG+ G SGV+TSP YPN Y + C ++ A + L F DF +E +
Sbjct: 136 FSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGN 195
Query: 2740 TTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWN 2799
C +D V V G P YCG++ P T+ S ++L V F SD ++ G GF A +
Sbjct: 196 EECTYDYVAVLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF 253
Query: 2800 TQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISF-DNNFLIPSG-D 2857
+ C ++ + G SP +P ++P N RC WT +++ F D + P+
Sbjct: 254 SGE--CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLT 311
Query: 2858 GQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPA-QGFSASF 2916
C + + G E + LL CG+ P PV + N + + + +GFS ++
Sbjct: 312 KTCDFDHLAAFDGASE-EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
Query: 2917 VS---RCGSNFTGPSGYIISP 2934
+ CGS T G + P
Sbjct: 371 IGGQLGCGSGSTEGEGEALQP 391
Score = 169 bits (427), Expect = 6e-41
Identities = 109/362 (30%), Positives = 175/362 (48%), Gaps = 18/362 (4%)
Query: 2451 ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHV 2510
+CGG L G F+SPN+P P+ C W I EG + L F+ L H +C+ + +
Sbjct: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
Query: 2511 IVFNGIRSNSPQ-LEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAV 2569
++NG + L + C V SS + M VIF +D GF+A Y + V
Sbjct: 89 EIYNGASPDKGNLLGRFCGKV-PPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDV 144
Query: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQ 2629
CGG L G TSP Y NY ++ C W + G + + + F DF +E +++C
Sbjct: 145 CGGVLTGL-SGVLTSPEYP--NNYPNSMECHWVIR--AAGPAHVKLVFVDFQVEGNEECT 199
Query: 2630 FDVLEFRVGDADGPLM-WRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD 2688
+D + G GP CG ++P LV ++ + F ++ + GF A Y +
Sbjct: 200 YDYVAVLGG--PGPTRGHHYCGSTRPP-TLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE 256
Query: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDI-EPHT---TCAW 2744
C + + G +SP YP++Y + C + P G+ + + F D D+ EP++ TC +
Sbjct: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
Query: 2745 DSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLG 2804
D + +G S E+P++G +CG+ P + S NQL++ ++D S GF + LG
Sbjct: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG 376
Query: 2805 CG 2806
CG
Sbjct: 377 CG 378
Score = 167 bits (423), Expect = 2e-40
Identities = 117/378 (30%), Positives = 178/378 (47%), Gaps = 25/378 (6%)
Query: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
CGG L+ + F+SP+ +Y N C W+I+ + LTF+ F LE T C
Sbjct: 30 CGGVLSAPSGNFSSPNFPR--LYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDT---CS 84
Query: 3217 YDYVKLYDGDS-ENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275
+D++++Y+G S + NL G FCG P PF SS + ++V F SD + GF+A Y D
Sbjct: 85 FDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ-KD 143
Query: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLT-SQDCTQ 3334
+ CGG T ++SP + C WVI + VK+ Q+ +++CT
Sbjct: 144 V-CGGVL--TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTY 200
Query: 3335 NYLQLQDSP---QGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQ 3391
+Y+ + P +GH +CG ++ P S V+FKS Y
Sbjct: 201 DYVAVLGGPGPTRGH-----HYCG--STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF 253
Query: 3392 IADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIE--NSVE-- 3447
+C Y GN SP +P +Y N+ C T+ P + + +FF L +E NS+
Sbjct: 254 SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
Query: 3448 CRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSS 3507
C D L +G++ +PLLG +CG LP PV S +N+L L +D T+ RG+ + +
Sbjct: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
Query: 3508 PSGCGGTLYGDRGSFTSP 3525
GCG G P
Sbjct: 374 QLGCGSGSTEGEGEALQP 391
Score = 166 bits (419), Expect = 5e-40
Identities = 106/362 (29%), Positives = 169/362 (46%), Gaps = 15/362 (4%)
Query: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
CGG+ SG +SPN+P Y T CS L+ +G ++ LTF FD+E H TC++D +
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 2749 VRNGGSPE-SPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGG 2807
+ NG SP+ ++G++CG P S + + V F+SD + GF A + CGG
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV--CGG 147
Query: 2808 IFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKV 2867
+ +G + SP +P N+P + C W H+++ F +F + G+ +C +V V
Sbjct: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF-VDFQV-EGNEECTYDYVAV 205
Query: 2868 WAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFVS-RCGSNFT 2925
G CG+ P +++ + VF+S +GF A + S C +
Sbjct: 206 LGGPGPTRGHHY---CGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYM 262
Query: 2926 GPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHII 2985
G SP YP Y NN+ C + I P V + F+ LE +++T +C D +
Sbjct: 263 AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAF 322
Query: 2986 RGYSVMSTPFATVCGDEMPAPLTIA-GPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFS 3044
G S + CG +P P+T + +LL +++ T GF +Y GG
Sbjct: 323 DGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY----IGGQLGCG 378
Query: 3045 SG 3046
SG
Sbjct: 379 SG 380
Score = 160 bits (405), Expect = 2e-38
Identities = 110/374 (29%), Positives = 165/374 (44%), Gaps = 27/374 (7%)
Query: 706 LRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
++CGG + P G P + + +C +++ +G + + F +L+ S ++
Sbjct: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
Query: 766 IEVRDGET-----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV-ACGD 819
+E+ +G + LLG+ CG S + + + F D V F A YQ CG
Sbjct: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
Query: 820 ELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGS 878
LTG GV+ SP +PN YP C W I + L F F++ + C DYV
Sbjct: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV---- 203
Query: 879 SSILGSP---ENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMA-KFSAEDLACGE 934
++LG P YCG+ P + S+ + L V F + GF A FS E C E
Sbjct: 204 -AVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE---CQE 259
Query: 935 ILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLE----FHYNCTNDYL 990
+ G SP +P+ YP+ I C W I + P + + + F LE C D+L
Sbjct: 260 VYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHL 319
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
+D SE + LG +CG +PP +TSS N L+L+ TD GF + Y I C
Sbjct: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY--IGGQLGC 377
Query: 1049 LQDYTDDLGTFTSP 1062
T+ G P
Sbjct: 378 GSGSTEGEGEALQP 391
Score = 159 bits (402), Expect = 5e-38
Identities = 102/367 (27%), Positives = 167/367 (45%), Gaps = 13/367 (3%)
Query: 589 ECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYL 648
+CGG+L+ P G+ SP +P YP +C W++V + V TF LE+HD C+ D+L
Sbjct: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
Query: 649 EIRDGPL-YQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLR 707
EI +G + LLG+FC PP ++ + FHSD ++ GF Y
Sbjct: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV---- 144
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CGG T G L PE + ++ +C ++++ +++ F +++ + + +Y+
Sbjct: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
Query: 768 V--RDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDE--LTG 823
V G T CG+ + S+ + + + FK D ++ F+A Y E +
Sbjct: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
Query: 824 EGVIRSPFFPNVYPGERTCRWTIHQP---QSQVILLNFTVFEIGS-SAHCETDYVEIGSS 879
G SP +P+ YP C WTI P Q +V L+ + E S + C+ D++
Sbjct: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
Query: 880 SILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTES 939
+ +P +CG +P +TS +N L + ST GF + L CG TE
Sbjct: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTEG 384
Query: 940 TGTIQSP 946
G P
Sbjct: 385 EGEALQP 391
Score = 152 bits (384), Expect = 6e-36
Identities = 110/395 (27%), Positives = 178/395 (45%), Gaps = 28/395 (7%)
Query: 2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGD 2151
CGG L A G +SP +P YP N CSW ++V G ++ + F F + D+ D
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF-HAFDLEYHDTC--SFD 86
Query: 2152 YLVLRNGPDICSPPLGPPGGN--GHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209
+L + NG P GN G FCG +S + M V F SD GF
Sbjct: 87 FLEIYNG-------ASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAG 139
Query: 2210 YEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDI 2269
Y+ CGG + +G +TSP +P+NYP +C W++ A ++L F D F +
Sbjct: 140 YQKD--VCGGVL----TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD-FQV 192
Query: 2270 EVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKA 2329
E CT +Y+ + G +CG++ P + S G + + F+SD + GFKA
Sbjct: 193 EGNEECTYDYVAVLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
Query: 2330 KYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSG 2389
Y +C G S +P+ Y +N+ C W ++ G+ + + F D +L+ +
Sbjct: 251 YYFSGECQEVYMAMRGNFSSPQYPS-SYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNS 309
Query: 2390 ----CEKDFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLR 2444
C+ D + +D + +LG +CG+ +P + +S N ++ TD S T GF +
Sbjct: 310 LTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVA 369
Query: 2445 FESSMEECG-GDLQGSIGTFTSPNYPNPNPHGRIC 2478
+ CG G +G + +P+ +C
Sbjct: 370 YIGGQLGCGSGSTEGEGEALQPQSLQSPSSIPPVC 404
Score = 152 bits (384), Expect = 6e-36
Identities = 105/371 (28%), Positives = 164/371 (44%), Gaps = 23/371 (6%)
Query: 474 CGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQ 533
CG LS +G+FS + Y ++ C W+I G + +TF F LE D C +FL+
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 534 VYDGDSSSAFQL-GRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGG 592
+Y+G S L GRFCG P SS + + +S+ GF+ + Q+ CGG
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVCGG 147
Query: 593 ILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD 652
+LTG G + SP YP NYP +C W++ + V F +E +++C DY+ +
Sbjct: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
Query: 653 GPLYQDPLLG-KFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGN 711
GP P G +C + P L + G ++ F SD I +GF Y + C
Sbjct: 208 GP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSG----ECQEV 260
Query: 712 YTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ--------CQSDSSQ 763
Y G P+ + + +C + ++ P G Q+++ F ++L+ C D
Sbjct: 261 YMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
Query: 764 NYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY---QVACGDE 820
+ + LLG CG+ + S N + + D S + F Y Q+ CG
Sbjct: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSG 380
Query: 821 LT-GEGVIRSP 830
T GEG P
Sbjct: 381 STEGEGEALQP 391
Score = 150 bits (379), Expect = 2e-35
Identities = 130/473 (27%), Positives = 201/473 (42%), Gaps = 50/473 (10%)
Query: 1840 GTGFQATFMKIFGNDNIVGT-HGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMD 1898
G G QA M+ ++ G +SP +P YP+N+ W + V V D
Sbjct: 17 GPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFD 76
Query: 1899 IEEIQNCYYDKLRIYDGPSIH-ARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGF 1956
+E C +D L IY+G S L+G +CG F+S+ + ++ F+SD ++ GF
Sbjct: 77 LEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGF 136
Query: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST 2016
+ CGG L TG + V L SP +P++Y N ++C W+I+A
Sbjct: 137 SAGY-------------QKDVCGGVL-TGLSGV-LTSPEYPNNYPNSMECHWVIRAAGPA 181
Query: 2017 -VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTS 2075
V+L + +E + C YD + + G CG P + S G + + F S
Sbjct: 182 HVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPTLVSLGHELQVVFKS 239
Query: 2076 DSSVTRAGFNAS-FHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHF 2134
D ++ GF A F C A RG +SP+YP +YP+N+ C W + + G + V F
Sbjct: 240 DFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFF 299
Query: 2135 -EQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFV 2193
+ + PN + D+L +G +P L G++CG H + +S NQ+ +
Sbjct: 300 LDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLL------GNWCGHHLPPPVTSSHNQLLL 353
Query: 2194 QFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSP---NHPHNYPPHADCIWI 2250
+D S +GF + Y L CG + G P P + PP +
Sbjct: 354 LLHTDRSTTRRGFSVAYIGGQLGCGSG----STEGEGEALQPQSLQSPSSIPP------V 403
Query: 2251 LAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPS 2303
APP + LQ + + P S L L D AP +C S PS
Sbjct: 404 CPAPPMNGL-LQLLLHW---LHPCPLSGPLRL----DGTAPACFHYCRASFPS 448
Score = 140 bits (352), Expect = 3e-32
Identities = 104/351 (29%), Positives = 155/351 (44%), Gaps = 17/351 (4%)
Query: 3278 CGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNY 3336
CGG +A N SSPN + C+W+I V +T A L D C+ ++
Sbjct: 30 CGGVLSAP--SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
Query: 3337 LQLQDSPQ-GHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADC 3395
L++ + GN +FCG+ P F SS VIF S + S YQ C
Sbjct: 88 LEIYNGASPDKGNLLGRFCGKVPP--PPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
Query: 3396 NRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEV 3455
G L SP +P+NY N +C + A + L F +E + EC D++ V
Sbjct: 146 GGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAV 205
Query: 3456 RNGSNSNSPLLGK-YCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGT 3514
G P G YCG+ P + S +EL + FKSD RG++ + S C
Sbjct: 206 LGGPG---PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE--CQEV 260
Query: 3515 LYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGD----CVQNYLT 3570
RG+F+SP YP +YPNN C W + P G V + F + +++P C ++L
Sbjct: 261 YMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
Query: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621
+DG + +P G +CG P +S NQ+ + H D + F + +
Sbjct: 321 AFDGASEEAPLLGNWCGHHLP-PPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
Score = 139 bits (349), Expect = 7e-32
Identities = 101/329 (30%), Positives = 147/329 (44%), Gaps = 23/329 (6%)
Query: 3035 ISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHD 3094
+ CGGV + SG +SP + YP + C + I V++ + L F FD+ +CS D
Sbjct: 28 VKCGGVLSAPSGNFSSPNFPRL-YPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFD 86
Query: 3095 YLAIYDGAN-TSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGP 3153
+L IY+GA+ LLG+FCG PP SS + M ++F +D + G+ +++ +
Sbjct: 87 FLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV-- 144
Query: 3154 QQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQ 3213
CGG LTG + SP+ +N Y ++ C W+I A + L F F +E +
Sbjct: 145 ---CGGVLTGLSGVLTSPEYPNN--YPNSMECHWVIRAAGPAHVKLVFVDFQVEG---NE 196
Query: 3214 RCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTI 3273
C YDYV + G +CGST P +S G+ L V F SD + GF A Y
Sbjct: 197 ECTYDYVAVLGGPGPTR--GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY-- 252
Query: 3274 MDMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQL-----T 3328
C Y A N SSP C W I PP QVK+ L L
Sbjct: 253 FSGECQEVYMA--MRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSL 310
Query: 3329 SQDCTQNYLQLQDSPQGHGNSRFQFCGRN 3357
++ C ++L D +CG +
Sbjct: 311 TKTCDFDHLAAFDGASEEAPLLGNWCGHH 339
Score = 112 bits (279), Expect = 9e-24
Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 10/257 (3%)
Query: 471 QQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHE 530
+ VCG L+G++G + Y + + C WVI+ +++ F F++E + C ++
Sbjct: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
Query: 531 FLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPEC 590
++ V G + +CGS+ P L+S + L S+ GRGF + + EC
Sbjct: 202 YVAVLGGPGPTRGH--HYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS--GEC 257
Query: 591 GGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD----CNKD 646
+ G+ SP YP +YP C W + P V F L LE + C+ D
Sbjct: 258 QEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFD 317
Query: 647 YLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDL 706
+L DG + PLLG +C PP+ ++ + H+D + +GF + Y+ L
Sbjct: 318 HLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYI--GGQL 375
Query: 707 RCGGNYTDPEGELFLPE 723
CG T+ EGE P+
Sbjct: 376 GCGSGSTEGEGEALQPQ 392
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 207 bits (527), Expect = 2e-52
Identities = 119/355 (33%), Positives = 173/355 (48%), Gaps = 39/355 (10%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F+G+ ++ C SNPC N G C++ + F C+CPP + GP+C D+++C S TP
Sbjct: 486 FKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDC---SSTP-- 540
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C NG C++ Y C C G C D+C+ C HG C+D G Y
Sbjct: 541 CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDP---CHHGQCQD------GIDSY 591
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYIC 303
+C+C+ G+M C+ DEC PC +C + + C C G G
Sbjct: 592 TCICNPGYM----GAICSDQIDEC--YSSPCLNDGRCIDLVNGYQCN-CQPGTSG----- 639
Query: 304 EDINECEINNGGCSVAPPVECVNTPG-SSHCQACPPGYQGDGRVCTLTDICSVSNGGCHP 362
+N CEIN C+ P + + G + + C PG+ G C + DI ++ C
Sbjct: 640 --VN-CEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQR--CNI-DIDECASNPCRK 693
Query: 363 DASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDS 422
A+C + + C C G + P+ C N CLS+PC++G C +SGY C CD+
Sbjct: 694 GATCINGVNGFR-CICPEG----PHHPS-CYSQVNECLSNPCIHGNCTGGLSGYKCLCDA 747
Query: 423 GWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
GW G+NC + NECLSNPC NGGTC + V+ + C C + + G CQV C +
Sbjct: 748 GWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASN 802
Score = 207 bits (526), Expect = 2e-52
Identities = 128/359 (35%), Positives = 172/359 (47%), Gaps = 46/359 (12%)
Query: 126 GLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQ 185
G+ VDK C SNPCQNGGTC NL + + C C +KG C +++EC + P C
Sbjct: 751 GINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDEC---ASNP--CL 805
Query: 186 NGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICED--LMREQAGEPKY 243
N GTC + + Y+CHC G C + +A C CE+ + +E Y
Sbjct: 806 NQGTCFDDISGYTCHCVLPYTGKNCQTV--------LAPCSPNPCENAAVCKESPNFESY 857
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYIC 303
+C+C GW CT+D DEC +P C C NTQGS+ C CP G+ G C
Sbjct: 858 TCLCAPGWQ----GQRCTIDIDECISKP--CMNHGLCHNTQGSYMC-ECPPGFSGMD--C 908
Query: 304 E-DINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
E DI++C N NGG C++ + C C PG+ GD TD+ +
Sbjct: 909 EEDIDDCLANPCQNGG-------SCMDGVNTFSC-LCLPGFTGDK---CQTDMNECLSEP 957
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFC 418
C +CS + S C C G+ G C N C C NG C+D ++ + C
Sbjct: 958 CKNGGTCSDYVNSYT-CKCQAGFDGVH-----CENNINECTESSCFNGGTCVDGINSFSC 1011
Query: 419 KCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
C G+TG C INEC S+PCLN GTCVDG+ ++ C C +TG CQ +C S
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRS 1070
Score = 202 bits (515), Expect = 4e-51
Identities = 141/434 (32%), Positives = 176/434 (40%), Gaps = 102/434 (23%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C S+PC NG TC + + F C C + G C DVNEC+I P CQ+GGTC+N G
Sbjct: 148 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI----PGHCQHGGTCLNLPG 203
Query: 196 SYSCHCPPETYGPQCASKYDDC---------------------------EGGSVARCVH- 227
SY C CP G C S Y C EG + R +
Sbjct: 204 SYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDD 263
Query: 228 ---------GICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLV 278
G+C D G Y+C C W CT D DEC QP C
Sbjct: 264 CPNHRCQNGGVCVD------GVNTYNCRCPPQW----TGQFCTEDVDECLLQPNACQNGG 313
Query: 279 QCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPP 338
C N G + C C GW G+ E+I++C S P C++ S C CP
Sbjct: 314 TCANRNGGYGC-VCVNGWSGDD-CSENIDDCAF----ASCTPGSTCIDRVASFSCM-CPE 366
Query: 339 GYQGDGRVCTLTDICSVSNGGCHPDASCSST-LGSLPLCTCLPGYTG------------- 384
G G +C L D C +SN CH A C + L +CTC GY G
Sbjct: 367 GKAG--LLCHLDDAC-ISNP-CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMA 422
Query: 385 -----------------------NGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKC 420
GY C N C S PC N C+D + G+ C C
Sbjct: 423 NSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLC 482
Query: 421 DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG 480
G+ GV+C INEC SNPC+N G CVD V+ F C C +TG +CQ+ C S
Sbjct: 483 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDC-SSTPC 541
Query: 481 INGSFSYRSPDVGY 494
+NG+ P+ GY
Sbjct: 542 LNGAKCIDHPN-GY 554
Score = 194 bits (494), Expect = 1e-48
Identities = 138/415 (33%), Positives = 178/415 (42%), Gaps = 77/415 (18%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNEC--------- 174
F G + +D C+SNPC+ G TC+N + F CICP P C + VNEC
Sbjct: 674 FTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGN 733
Query: 175 ---------------------EIYSGTPLS--CQNGGTCVNTMGSYSCHCPPETYGPQCA 211
E+ LS CQNGGTC N + Y C C G C
Sbjct: 734 CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ 793
Query: 212 SKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQP 271
D+C G C D + +G Y+C C + C CS P
Sbjct: 794 VNIDECASNPCLN--QGTCFD---DISG---YTCHC----VLPYTGKNCQTVLAPCS--P 839
Query: 272 GPCSTLVQCFNTQG--SFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVE---CVN 326
PC C + S+ C C GWQG C I+ C P + C N
Sbjct: 840 NPCENAAVCKESPNFESYTC-LCAPGWQGQ--------RCTIDIDECISKPCMNHGLCHN 890
Query: 327 TPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNG 386
T GS C+ CPPG+ G + DI C SC + + C CLPG+TG+
Sbjct: 891 TQGSYMCE-CPPGFSG---MDCEEDIDDCLANPCQNGGSCMDGVNTFS-CLCLPGFTGDK 945
Query: 387 YGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGG 445
C N CLS PC NG C D V+ Y CKC +G+ GV+C NINEC + C NGG
Sbjct: 946 -----CQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGG 1000
Query: 446 TCVDGVDSFSCECTRLWTGALC-----QVPQQVCGESLSGINGSFSYR-SPDVGY 494
TCVDG++SFSC C +TG+ C + C + ++G +YR S +GY
Sbjct: 1001 TCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055
Score = 186 bits (472), Expect = 4e-46
Identities = 122/379 (32%), Positives = 169/379 (44%), Gaps = 62/379 (16%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F G+ D C +NPCQNGG+C++ ++F C+C P + G C D+NEC
Sbjct: 903 FSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNEC-----LSEP 957
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPK 242
C+NGGTC + + SY+C C G C + ++C S C +G C D G
Sbjct: 958 CKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESS---CFNGGTCVD------GINS 1008
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
+SC+C G+ S C + +ECS P C C + G++ C +CP G+ G
Sbjct: 1009 FSCLCPVGFTGS----FCLHEINECSSHP--CLNEGTCVDGLGTYRC-SCPLGYTGKN-- 1059
Query: 303 CEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
C+ CS +P CV S C CP G+ G C V N
Sbjct: 1060 ------CQTLVNLCSRSPCKNKGTCVQKKAESQC-LCPSGWAGA--------YCDVPNVS 1104
Query: 360 CHPDASCSSTL--------------GSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL 405
C AS L G+ C C GYTG+ C + + C S+PC
Sbjct: 1105 CDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSY-----CEEQLDECASNPCQ 1159
Query: 406 NGQ-CIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTG 464
+G C D + GY C+C G+ GVNC ++EC + PC NGGTC+D V+ F C C G
Sbjct: 1160 HGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRG 1219
Query: 465 ALCQVPQQVCGESLSGING 483
LC+ C +NG
Sbjct: 1220 LLCEENIDDCARGPHCLNG 1238
Score = 185 bits (469), Expect = 8e-46
Identities = 130/433 (30%), Positives = 182/433 (42%), Gaps = 104/433 (24%)
Query: 129 QTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGG 188
+ VD+ + N CQNGGTC N + + C+C W G CS ++++C S TP G
Sbjct: 297 EDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP-----GS 351
Query: 189 TCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICED--LMREQAGEPKYSCV 246
TC++ + S+SC CP G C DD C+ C L +Y C
Sbjct: 352 TCIDRVASFSCMCPEGKAGLLC--HLDDA-------CISNPCHKGALCDTNPLNGQYICT 402
Query: 247 CDAGWMFSPNSPACTLDRDECSF-QPGPCSTLVQCFNTQGSFYCGACPTGWQG------- 298
C G+ CT D DEC+ PC +C NT G+F+C C G+ G
Sbjct: 403 CPQGY----KGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHC-ECLKGYAGPRCEMDI 457
Query: 299 -----------------------------NGYICE-DINECE----INNGGC-------- 316
G CE +INEC+ +NNG C
Sbjct: 458 NECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQ 517
Query: 317 SVAPP-----------VECVNTP--GSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPD 363
+ PP +C +TP + C P GY+ +C + C PD
Sbjct: 518 CLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPD 577
Query: 364 ----ASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFC 418
C + S C C PGY G C + C S PCLN G+CID V+GY C
Sbjct: 578 PCHHGQCQDGIDSY-TCICNPGYMG-----AICSDQIDECYSSPCLNDGRCIDLVNGYQC 631
Query: 419 KCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES- 477
C G +GVNC N ++C SNPC++ G C+DG++ +SC C+ +TG C + C +
Sbjct: 632 NCQPGTSGVNCEINFDDCASNPCIH-GICMDGINRYSCVCSPGFTGQRCNIDIDECASNP 690
Query: 478 -------LSGING 483
++G+NG
Sbjct: 691 CRKGATCINGVNG 703
Score = 171 bits (432), Expect = 2e-41
Identities = 131/421 (31%), Positives = 178/421 (42%), Gaps = 87/421 (20%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F G + D C S PC+NGGTC + +S+ C C + G C ++NEC T S
Sbjct: 941 FTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINEC-----TESS 995
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPK 242
C NGGTCV+ + S+SC CP G C + ++C S C++ G C D G
Sbjct: 996 CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINEC---SSHPCLNEGTCVD------GLGT 1046
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
Y C C G+ C + CS PC C + C CP+GW G
Sbjct: 1047 YRCSCPLGY----TGKNCQTLVNLCS--RSPCKNKGTCVQKKAESQC-LCPSGWAGA--- 1096
Query: 303 CEDINECEINNGGCSVAPP-----VE--------CVNTPGSSHCQACPPGYQGDGRVCTL 349
C++ N C +A VE C+N + +CQ CP GY G L
Sbjct: 1097 -----YCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQ-CPLGYTGSYCEEQL 1150
Query: 350 TDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTG-----------NGYGPNG--CVQLS 396
+ S C A+CS +G C C+PGY G N NG C+ L
Sbjct: 1151 DECAS---NPCQHGATCSDFIGGYR-CECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLV 1206
Query: 397 NI--------------------CLSHP-CLNG-QCIDTVSGYFCKCDSGWTGVNCTENIN 434
N C P CLNG QC+D + GY C+C G+ G C +IN
Sbjct: 1207 NHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDIN 1266
Query: 435 ECLSNPCLNGGT--CVDGVDSFSCECTRLWTGALCQVPQQVCGE--SLSGINGSFSYRSP 490
ECLSNPC + G+ C+ + + C C +TG C+ VC + L+G + + P
Sbjct: 1267 ECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMP 1326
Query: 491 D 491
D
Sbjct: 1327 D 1327
Score = 151 bits (382), Expect = 1e-35
Identities = 116/338 (34%), Positives = 154/338 (45%), Gaps = 46/338 (13%)
Query: 140 PCQNGGTCLNLHD-SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCV--NTMGS 196
PC N G C+ H+ + +C CP + G C + CE CQNGGTCV +G
Sbjct: 34 PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCE-----KNRCQNGGTCVAQAMLGK 87
Query: 197 YSCHCPPETYGPQCASKYDDCEGGSVAR-CVH-GICEDLMREQAGEPKYSCVCDAGWMFS 254
+C C G C +Y V+R C++ G C L R+ Y C C G+
Sbjct: 88 ATCRCASGFTGEDC--QYSTSHPCFVSRPCLNGGTCHMLSRD-----TYECTCQVGF--- 137
Query: 255 PNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINN 313
C D C PC+ C F C C TG+ G CE D+NEC+I
Sbjct: 138 -TGKECQW-TDACLSH--PCANGSTCTTVANQFSC-KCLTGFTGQK--CETDVNECDI-P 189
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVC-TLTDICSVSNGGCHPDASCSSTLGS 372
G C C+N PGS CQ CP G+ G+ C +L C+ S C +C T
Sbjct: 190 GHCQHGG--TCLNLPGSYQCQ-CPQGF--TGQYCDSLYVPCAPS--PCVNGGTCRQTGDF 242
Query: 373 LPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTE 431
C CLPG+ G + C + + C +H C N G C+D V+ Y C+C WTG CTE
Sbjct: 243 TFECNCLPGFEG-----STCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTE 297
Query: 432 NINECLSNP--CLNGGTCVDGVDSFSCECTRLWTGALC 467
+++ECL P C NGGTC + + C C W+G C
Sbjct: 298 DVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Score = 134 bits (336), Expect = 2e-30
Identities = 102/382 (26%), Positives = 153/382 (40%), Gaps = 81/382 (21%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSG-----TPLSCQNGGT 189
+CS +PC+N GTC+ C+CP W G C C+I + CQ+ G
Sbjct: 1066 LCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGV 1125
Query: 190 CVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPKYSCVCD 248
C+N ++ C CP G C + D+C C HG C D + Y C C
Sbjct: 1126 CINAGNTHYCQCPLGYTGSYCEEQLDECASNP---CQHGATCSDFIGG------YRCECV 1176
Query: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICED-IN 307
G+ C + DEC QP C C + F C +CP G +G +CE+ I+
Sbjct: 1177 PGYQ----GVNCEYEVDECQNQP--CQNGGTCIDLVNHFKC-SCPPGTRG--LLCEENID 1227
Query: 308 ECEIN----NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPD 363
+C NGG +C++ G C+ C PG+ G+ C DI + C +
Sbjct: 1228 DCARGPHCLNGG-------QCMDRIGGYSCR-CLPGFAGER--CE-GDINECLSNPCSSE 1276
Query: 364 ASCSST-LGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVS----GYFC 418
S L + LC C +TG C ++C PCLNG S G+ C
Sbjct: 1277 GSLDCIQLTNDYLCVCRSAFTGRH-----CETFVDVCPQMPCLNGGTCAVASNMPDGFIC 1331
Query: 419 KCDSGWTGVNCTENINE-----------------------------CLSNPCLNGGTCVD 449
+C G++G C + + C S+PC +GG+C
Sbjct: 1332 RCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHP 1391
Query: 450 GVDS--FSCECTRLWTGALCQV 469
+SC+C ++G+ C++
Sbjct: 1392 QRQPPYYSCQCAPPFSGSRCEL 1413
Score = 103 bits (257), Expect = 3e-21
Identities = 75/234 (32%), Positives = 108/234 (46%), Gaps = 25/234 (10%)
Query: 273 PCSTLVQCFNTQ-GSFYCGACPTGWQGNGYICEDINECEIN---NGGCSVAPPVECVNTP 328
PC C G+ YC CP G+ G C+ + CE N NGG VA +
Sbjct: 34 PCVNEGMCVTYHNGTGYC-KCPEGFLGE--YCQHRDPCEKNRCQNGGTCVAQAML----- 85
Query: 329 GSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYG 388
G + C+ C G+ G+ + + C VS C +C CTC G+TG
Sbjct: 86 GKATCR-CASGFTGEDCQYSTSHPCFVSRP-CLNGGTCHMLSRDTYECTCQVGFTGKE-- 141
Query: 389 PNGCVQLSNICLSHPCLNGQCIDTVSGYF-CKCDSGWTGVNCTENINEC-LSNPCLNGGT 446
Q ++ CLSHPC NG TV+ F CKC +G+TG C ++NEC + C +GGT
Sbjct: 142 ----CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGT 197
Query: 447 CVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500
C++ S+ C+C + +TG C C S +NG ++ D + + NC
Sbjct: 198 CLNLPGSYQCQCPQGFTGQYCDSLYVPCAPS-PCVNGGTCRQTGD--FTFECNC 248
Score = 71.6 bits (174), Expect = 1e-11
Identities = 63/249 (25%), Positives = 88/249 (35%), Gaps = 46/249 (18%)
Query: 135 VCSSNPCQNGGTCL---NLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCV 191
VC PC NGGTC N+ D F C CPP + G C + + + C+ G CV
Sbjct: 1307 VCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQ--------VKCRKGEQCV 1358
Query: 192 NTMGSYSCHCPPETYGPQCASKYDDCEGGSVAR-CVHGICEDLMREQAGEPKYSCVCDAG 250
+T C CP DCE G + C HG Q P YSC C
Sbjct: 1359 HTASGPRCFCPSPR----------DCESGCASSPCQHG---GSCHPQRQPPYYSCQCAPP 1405
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINEC 309
+ + C L S P C + + AC N + C+ D +C
Sbjct: 1406 F----SGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEAC------NSHACQWDGGDC 1455
Query: 310 EI--NNGGCSVAPPVEC---VNTPGSSHCQACPPGY-----QGDGRVCTLTDICSVSNGG 359
+ N + + P+ C +N C + QG+ + C C+
Sbjct: 1456 SLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKD 1515
Query: 360 CHPDASCSS 368
H D C+S
Sbjct: 1516 NHCDQGCNS 1524
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 205 bits (522), Expect = 6e-52
Identities = 128/386 (33%), Positives = 180/386 (46%), Gaps = 49/386 (12%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
CG Q +G SP YP+ Y ++ C W I V +++LNFT DL C Y
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
DG R CG +L PIVS+ + L++ F+S + +GF A + CGG +
Sbjct: 382 VRDGFWRKAPLRGRFCG-SKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV- 439
Query: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
+ + SP +P +Y ++ C W IQ H+ L+F FE+ER +CA D++E+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGF-HVGLTFQSFEIERHDSCAYDYLEVRDG 498
Query: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASV---------- 1735
E + L GRYCG + P I S SS L L+FVSD SI+ GF V
Sbjct: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1736 ------------------------------SACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
+ACGG G SPG+P YPPN C+
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
W +V+ R+ L F F+ E + C DFVE+R G A L G++CG+ P +S
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY 678
Query: 1825 GHTLWVRFISDGSGSGTGFQATFMKI 1850
+ + V F SD + S GF+A F +
Sbjct: 679 -NNMRVEFKSDNTVSKKGFKAHFFSV 703
Score = 198 bits (503), Expect = 9e-50
Identities = 130/407 (31%), Positives = 192/407 (47%), Gaps = 55/407 (13%)
Query: 1606 SRQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHI 1660
+R ++G AQ R+ ACG L S SSP +P Y + +C W I P I
Sbjct: 303 TRLSKGDIAQARKLYKCPACG-ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPG-EKI 360
Query: 1661 TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDS 1720
L+FT +L RS C D+VE+ DG APLRGR+CG+ +P PI S S L + F S S
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 1721 SISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSF 1780
+ GF A CGG G SP YPD Y P+ C+W I S G + L+F
Sbjct: 421 NWVGKGFFAVYEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
Query: 1781 ISFQLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGS 1839
SF++E C+ D++E+R+G++ + L+GRYCG P + S LW++F+SDGS +
Sbjct: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS-TSSRLWLKFVSDGSIN 536
Query: 1840 GTGFQATFMKIFGND-------------NIVGTH-------------------------- 1860
GF F K N +G++
Sbjct: 537 KAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLT 596
Query: 1861 ---GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917
G + SP WP+ YP N N W + + + + + E C YD + + G +
Sbjct: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656
Query: 1918 IHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWFAV 1963
++L G +CG++ E +S N++ F SD+++S KGF +F+V
Sbjct: 657 ADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
Score = 192 bits (487), Expect = 7e-48
Identities = 123/384 (32%), Positives = 179/384 (46%), Gaps = 56/384 (14%)
Query: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
CG L +TG+FSSP +PN Y + C+W I PG I L D+ C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
+ G +P + C + PE + ST + L + F++ + G+GF A ++A+ C
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPE---PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---C 435
Query: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
GG + G I SPNYP YR + C W I+V V L F F++E DSC Y
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
DG S + + + R CG E+ + I S+ + L+L+F S S GF F
Sbjct: 496 RDGHSESSTLIGRYCGYEK-PDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
ACGG LT +++SP +P YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWPKEYPP 613
Query: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
N+NC W + A P I+L F FE E + C DFVE+ G D+ L G++CG++ P
Sbjct: 614 NKNCIWQLVA-PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 672
Query: 1704 PITSFSSALTLRFVSDSSISAGGF 1727
ITS + + + F SD+++S GF
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGF 696
Score = 189 bits (480), Expect = 4e-47
Identities = 125/391 (31%), Positives = 182/391 (46%), Gaps = 48/391 (12%)
Query: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
ACGE L +STG SP +PN Y ++C W I V P I L F + L C DY+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
EV D + GR+CG +P + S+ + L + F + S+ +GF YEAI C
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-----C 435
Query: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
D D G SPN+P++Y + CI+RI V G + + F +F +E Y D+LE
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYLE 494
Query: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWD--------- 1159
+RDG E S L+G + G P I S S++LWLKF SD ++GF+ +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188
GS CGG LT +G+ SP +P Y +
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
C W L + L+F F E + C D++ V G +++S L + CG EKP +I
Sbjct: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
Query: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEYRQTCE 1279
S ++M ++ ++D +GFKA + E
Sbjct: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
Score = 186 bits (473), Expect = 3e-46
Identities = 118/401 (29%), Positives = 191/401 (47%), Gaps = 52/401 (12%)
Query: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
AC + D G F+SP +PN Y + C++RI+V G+ I ++FT+ L + +Y D+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY-DY 379
Query: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
+E+RDG + K+PL G F GS LP I+S ++LW++F+S GF A ++ CG
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---CG 436
Query: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
G++ G SPNYP Y S C W ++ S G L F+ F +E H +C DYL V
Sbjct: 437 GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVR 496
Query: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY------------ 1274
DG S +S L+ + CG EKP I+S+ +++K +D GF +
Sbjct: 497 DGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNR 556
Query: 1275 ---RQTCENVV--------------------------IVNQTYGILESIGYPNPYSENQH 1305
Q C N + + + G + S G+P Y N++
Sbjct: 557 GGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
Query: 1306 CNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGST 1361
C W + A T ++ F F+ E + C D++E+ G + G++CG + P ++
Sbjct: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
Query: 1362 TSSKLQVLLLTDGVGRREKGFQMQWF--VYGCGGELSGATG 1400
+ ++V +D + KGF+ +F + G G S +G
Sbjct: 677 QYNNMRVEFKSDNTVSK-KGFKAHFFSVLEGAGDRHSHLSG 716
Score = 186 bits (473), Expect = 3e-46
Identities = 116/393 (29%), Positives = 176/393 (44%), Gaps = 52/393 (13%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CG L S+G F SP YP Y C W + + G L F L C DY+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
V DG + L + CG + P I S+ ++++ R+ G+GF A Y C V
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV-- 439
Query: 1285 NQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP 1344
+ YG ++S YP+ Y ++ C W I+ + G V TF +F++E H +C+ DYLE+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGH 499
Query: 1345 RQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVY----------- 1389
+ +GRYCG + P +TSS+L + ++DG + GF + +F
Sbjct: 500 SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDG-SINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1390 -------------------------------GCGGELSGATGSFSSPGFPNRYPPNKECI 1418
CGG L+ GS +SPG+P YPPNK CI
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1419 WYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVS 1478
W + I L F+ E + C +D +E+ G S + C PE ++
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE---VIT 675
Query: 1479 STGNELAIRFKTDLSINGRGFNASWQAVTGGCG 1511
S N + + FK+D +++ +GF A + +V G G
Sbjct: 676 SQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
Score = 184 bits (468), Expect = 1e-45
Identities = 130/411 (31%), Positives = 185/411 (45%), Gaps = 48/411 (11%)
Query: 807 ASFRAVYQV-ACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
A R +Y+ ACG+ L G SP +PN Y C W I + I+LNFT ++
Sbjct: 311 AQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY 370
Query: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
S C DYVE+ +P ++CG+ +P I S + L+V F SS+ GF A
Sbjct: 371 RSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
Query: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
+ A CG + + G IQSP +P+ Y C W I V + L F++F +E H +
Sbjct: 431 YEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
Query: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
C DYLEV D SE+S +GRYCG P + S+ + L L FV+D + GF +N+
Sbjct: 488 CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547
Query: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
+ AC T G+ TSP +
Sbjct: 548 VDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGW 607
Query: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLE-EAIGNYYTDFLEIRDGGYEKSPLLGIF 1123
P YP N CI+++ T I++ F F E + Y DF+E+R G S L G F
Sbjct: 608 PKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY--DFVEVRSGLTADSKLHGKF 665
Query: 1124 YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSG 1174
GS P I S N + ++FKSD ++ GF A++ G G + SG
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSG 716
Score = 183 bits (465), Expect = 2e-45
Identities = 117/393 (29%), Positives = 185/393 (47%), Gaps = 49/393 (12%)
Query: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272
K ACG + DS G +SP +P+ Y H C+W ++ P +I L F D+ +
Sbjct: 318 KCPACGETLQ----DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS-LDLYRS 372
Query: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332
C +Y+E+RDG AP+ +FCG+ LP S+ +++ FRS ++ GF A Y
Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
Query: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392
A CGG V G ++S +P YR + C W +Q G ++ ++F+ F ++ C
Sbjct: 433 -AICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
Query: 2393 DFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451
D++E+ D H+ S ++GRYCG PD I ++S+ ++FV+DGS+ +GF + F ++E
Sbjct: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2452 ----------------------------------------CGGDLQGSIGTFTSPNYPNP 2471
CGG L G+ TSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
P + C W++ AP RI+L F+ + C + V V +G+ ++S K C S
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-E 669
Query: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS 2564
I S N M+V F +D + GF A + S
Sbjct: 670 KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 183 bits (465), Expect = 2e-45
Identities = 124/396 (31%), Positives = 184/396 (46%), Gaps = 57/396 (14%)
Query: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
ACG L+ D+ SP +P+ YS + C W I P + LN SLD+ R C YD
Sbjct: 321 ACGETLQ--DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
+ +RDG A CG ++P PI ST +++ F S S+ GF A + CGG
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
Query: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
+ D G I SP YP+ Y + C W + V G + + F Q F+I DS DYL +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDSCAY--DYLEV 495
Query: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
R+G S + G +CG + ++ ++++++F+SD S GF + +
Sbjct: 496 RDGHSESSTLI------GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
Query: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
E + L ACGG + G +TSP
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL----TKLNGSITSP 605
Query: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
P YPP+ +CIW L AP + RI LQF D F+ E C +++E+R G+ +D+ + K
Sbjct: 606 GWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
FCG+ P S M + F+SDN+ + GFKA +
Sbjct: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 171 bits (432), Expect = 2e-41
Identities = 118/410 (28%), Positives = 178/410 (43%), Gaps = 49/410 (11%)
Query: 448 VDGVDSFSCECTRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWV 503
V+GV + TRL G + Q + CGE+L G+FS GY ++C W
Sbjct: 292 VNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWR 351
Query: 504 IKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNA 563
I G+ + + FT L C +++++V DG A GRFCGS LP ++S+D+
Sbjct: 352 ISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSR 411
Query: 564 LYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTS 623
L+ S G+GF +E CGG + YG I+SP YP +Y P + C+W + S
Sbjct: 412 LWVEFRSSSNWVGKGFFAVYEAI---CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVS 468
Query: 624 PDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIH 683
V TF + +E HD C DYLE+RDG L+G++C +++T +
Sbjct: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
Query: 684 FHSDSQISDQGFHIT----------------------------------YLTSPSDLR-- 707
F SD I+ GF + Y +P R
Sbjct: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Query: 708 --CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
CGG T G + P + + C++ + P +I + F E + ++
Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
Query: 766 IEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRA 811
+EVR G T L GK CG+ I S N++ + FK D +V K F+A
Sbjct: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
Score = 169 bits (427), Expect = 6e-41
Identities = 122/392 (31%), Positives = 177/392 (45%), Gaps = 54/392 (13%)
Query: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQDC 2628
CG +L ++ GNF+SP Y YS +++C W +S P + I ++F L + C
Sbjct: 322 CGETLQDST-GNFSSPEYPN--GYSAHMHCVWRISVTPGE---KIILNFTSLDLYRSRLC 375
Query: 2629 QFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT 2687
+D +E R G PL R CG P P+V S++W+ F ++ GF A Y
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Query: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747
CGG D G I SPNYP+ Y C ++ +G + LTF F+IE H +CA+D +
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 2748 TVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ------ 2801
VR+G S S +IG+YCG P I+S S++L + F SD S+ GF + +
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 2802 ------------TLG----------------------CGGIFHSDNGTIRSPHWPQNFPE 2827
TLG CGG NG+I SP WP+ +P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 2828 NSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVA 2887
N C W + + + FD F G+ C+ FV+V +G D L CG+
Sbjct: 614 NKNCIWQLVAPTQYRISLQFD--FFETEGNDVCKYDFVEVRSGL-TADSKLHGKFCGSEK 670
Query: 2888 PGPVITPSNTFTAVFQSQEAPA-QGFSASFVS 2918
P + + N F+S + +GF A F S
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 163 bits (413), Expect = 3e-39
Identities = 115/390 (29%), Positives = 174/390 (44%), Gaps = 49/390 (12%)
Query: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979
CG +G SP YP Y +M+C + I P ++L F S L RS + C
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY-RSRL---CWY 377
Query: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038
D V + G+ + CG ++P P+ L + F S+ GF Y I CG
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
Query: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098
G G I SP Y DY C++ I VS+ + L F F++ SC++DYL +
Sbjct: 437 GDVKKDYGHIQSPNYP-DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF----------- 3147
DG + S L+G++CG ++P ++KS+++ + L F +D G+ ++F
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
Query: 3148 --------RQTLGP------------------QQGCGGYLTGSNNTFASPDSDSNGMYDK 3181
TLG + CGG+LT N + SP Y
Sbjct: 556 RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE--YPP 613
Query: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241
N NC+W ++AP I L F+ F E C YD+V++ G + ++ L G FCGS
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDV---CKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 3242 PAPFISSGNFLTVQFISDLTLEREGFNATY 3271
P S N + V+F SD T+ ++GF A +
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 160 bits (405), Expect = 2e-38
Identities = 112/380 (29%), Positives = 163/380 (42%), Gaps = 62/380 (16%)
Query: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----P 1344
G S YPN YS + HC W I T G + F + DL C DY+E+ DG
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
Query: 1345 RQMGRYCGVDLPPPGSTTSSKLQVLLLTDG--VGRREKGFQMQWFVYG--CGGELSGATG 1400
GR+CG LP P +T S+L V + VG KGF + VY CGG++ G
Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVG---KGF---FAVYEAICGGDVKKDYG 444
Query: 1401 SFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSP 1460
SP +P+ Y P+K CIW I+ G + LT F++E H C +D LE+ G S
Sbjct: 445 HIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESST 504
Query: 1461 RIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASW----------------- 1503
I + C P++ + ST + L ++F +D SIN GF ++
Sbjct: 505 LIGRYCGYEKPDD---IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
Query: 1504 -----------------------QAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVI 1540
+ CGG +G I SP +P Y N +C W +
Sbjct: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 1541 RVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNS 1596
+R+ L F F+ E D C + GL++ + CG E+ I S N+
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK-PEVITSQYNN 680
Query: 1597 LFLRFQSGPSRQNRGFRAQF 1616
+ + F+S + +GF+A F
Sbjct: 681 MRVEFKSDNTVSKKGFKAHF 700
Score = 159 bits (403), Expect = 4e-38
Identities = 105/382 (27%), Positives = 165/382 (43%), Gaps = 47/382 (12%)
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CG D G PE ++ CV+ + GE+I +NFT ++L +Y+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 768 VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823
VRDG L G+ CG+ I S + +W+ F+ ++ F AVY+ CG ++
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
Query: 824 E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882
+ G I+SP +P+ Y + C W I + + L F FEI C DY+E+
Sbjct: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
Query: 883 GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928
S +YCG + P I S + L++ FV S GF F E
Sbjct: 502 SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
Query: 929 --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962
+ ACG LT+ G+I SPG P YP NC W +
Sbjct: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 963 LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSL 1020
+ + I L F+ F E + C D++EV T G++CG P +TS N++
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNM 681
Query: 1021 MLVFVTDSDLAYEGFLINYEAI 1042
+ F +D+ ++ +GF ++ ++
Sbjct: 682 RVEFKSDNTVSKKGFKAHFFSV 703
Score = 158 bits (400), Expect = 8e-38
Identities = 111/406 (27%), Positives = 183/406 (45%), Gaps = 61/406 (15%)
Query: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
+CG L G +SP+YP Y ++++C W + V G I ++F + S
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS---LDLYRSRLCWY 377
Query: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
DY+ +R+G +P G FCGS + ++D++++V+F S + G+GF Y
Sbjct: 378 DYVEVRDGFWRKAPL------RGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
Query: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270
EA CGG+V G++ SPN+P +Y P CIW + + L F+ F+IE
Sbjct: 432 EA---ICGGDV----KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIE 483
Query: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330
+C +YLE+RDG + ++ ++CG P S+ ++L+F SD S GF
Sbjct: 484 RHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVN 543
Query: 2331 Y------------------------------------------SIAQCGGRVPGQSGVVE 2348
+ A CGG + +G +
Sbjct: 544 FFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSIT 603
Query: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNIL- 2407
S G P Y N C W L + + +++ F+ F + + C+ DFVE+ T+ + L
Sbjct: 604 SPGWPK-EYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLH 662
Query: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECG 2453
G++CG+ P+ I + N V F +D +V+ GF+ F S +E G
Sbjct: 663 GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
Score = 157 bits (398), Expect = 1e-37
Identities = 113/398 (28%), Positives = 175/398 (43%), Gaps = 53/398 (13%)
Query: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVW-IIIAPVNKVIHLTFNTFALEAASTRQRC 3215
CG L S F+SP+ + Y +++CVW I + P K+I L F + L + + C
Sbjct: 322 CGETLQDSTGNFSSPEYPNG--YSAHMHCVWRISVTPGEKII-LNFTSLDLYRS---RLC 375
Query: 3216 LYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275
YDYV++ DG A L G FCGS +P P +S+ + L V+F S +GF A Y +
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQ 3334
CGG + +I SPN D P +C W I V +T + ++ D C
Sbjct: 435 --CGGDVKKDYG--HIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
Query: 3335 NYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIAD 3394
+YL+++D ++CG SS + + ++F ++ +
Sbjct: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 3395 CNRDYH----------------------------------------KAFGNLRSPGWPDN 3414
C+R K G++ SPGWP
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 3415 YDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLL 3474
Y +K+C L AP + ISL F E + C+ DF+EVR+G ++S L GK+CG+
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 3475 PNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCG 3512
P + SQ N + + FKSD+ S +G++ + S G G
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
Score = 157 bits (396), Expect = 2e-37
Identities = 111/395 (28%), Positives = 173/395 (43%), Gaps = 70/395 (17%)
Query: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
G +SP +P Y + + W ++V + +D+ + C+YD + + DG A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
Query: 1921 RLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACG 1979
L G +CG++ E ST + L F S S+ GKGF + A+ CG
Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI--------------CG 436
Query: 1980 GFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLV 2038
G ++ + SP +PD Y C W IQ + V L S +IE H +CAYD L
Sbjct: 437 GDVKKDYGHIQ--SPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 2039 IRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK-------- 2090
+RDG + + + CG E P I+ST ++++F SD S+ +AGF +F K
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 2091 -----------------------------------SCGGYLHADRGIITSPKYPETYPSN 2115
+CGG+L G ITSP +P+ YP N
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 2116 LNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHF 2175
NC W ++ + I++ F+ F G+ C D++ +R+G S +G F
Sbjct: 615 KNCIWQLVAPTQYRISLQFD--FFETEGNDVCKY-DFVEVRSGLTADSKL------HGKF 665
Query: 2176 CGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
CGS + + N M V+F SD++ +GFK +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 149 bits (376), Expect = 5e-35
Identities = 112/398 (28%), Positives = 171/398 (42%), Gaps = 54/398 (13%)
Query: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
CG LQ S G F+SP YPN C WRI+ G +I L F +L L C ++V
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCG 2571
V +G +P + C S + I S+ + + V F + + GF A Y +A+CG
Sbjct: 382 VRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----EAICG 436
Query: 2572 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD 2631
G + G+ SP Y +Y + C W + + + F+ F +E H C +D
Sbjct: 437 GDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCAYD 491
Query: 2632 VLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------ 2684
LE R G ++ L+ R CG KP + S++W+ FV++ + GF +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2685 ------------------------------------SFTDCGGIQIGDSGVITSPNYPNA 2708
CGG +G ITSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2709 YDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Y +C L AP + I+L F F+ E + C +D V VR+G + +S + G++CG+
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCG 2806
P I S N + V F SD+++ GF A + + G G
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
Score = 148 bits (373), Expect = 1e-34
Identities = 105/395 (26%), Positives = 171/395 (43%), Gaps = 52/395 (13%)
Query: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Y CG + +G S +P Y ++ C W + G + ++F +L S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPN-GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
D+VE+ D + GR+CG+ +P+ I ++ + V F + + GF +E+
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
CGGD++ G SPNYP+ ++C WRI EG + L F + + H SC ++
Sbjct: 435 --CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
Query: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
+ V +G +S + + C ++IKS+ + + + F +DGS GF ++ D
Sbjct: 493 LEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
A CGG L G+ TSPG+
Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NGSITSPGWP-- 608
Query: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
+ Y N NC W L P Q IS+ F+ F E + C++D +E R G AD L + C
Sbjct: 609 KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
G KP + + Y+ + + F ++ V GF A +
Sbjct: 667 GSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 137 bits (344), Expect = 3e-31
Identities = 104/375 (27%), Positives = 163/375 (43%), Gaps = 54/375 (14%)
Query: 3292 SSPNSSDPDVPFSI-----CTWVIDSPPHQQVKITVWALQL-TSQDCTQNYLQLQDSPQG 3345
S+ N S P+ P C W I P +++ + +L L S+ C +Y++++D
Sbjct: 329 STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWR 388
Query: 3346 HGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGN 3405
R +FCG V S+ S V F+S N + F A C D K +G+
Sbjct: 389 KAPLRGRFCGSKLPEPIV--STDSRLWVEFRSSS-NWVGKGFFAVYEAICGGDVKKDYGH 445
Query: 3406 LRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPL 3465
++SP +PD+Y K C + + + L F S IE C D+LEVR+G + +S L
Sbjct: 446 IQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTL 505
Query: 3466 LGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY------EIIWTSSP----------- 3508
+G+YCG P+ + S ++ L+L+F SD + G+ E+ S P
Sbjct: 506 IGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLN 565
Query: 3509 -----------------------SGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPA 3545
+ CGG L GS TSPG+P YP N C W LVAP
Sbjct: 566 TLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPT 625
Query: 3546 GRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASS--NQVF 3603
+++ F F + C +++ + G A S G +CG + P V +S N +
Sbjct: 626 QYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSE---KPEVITSQYNNMR 682
Query: 3604 IKFHADYARRPSAFR 3618
++F +D F+
Sbjct: 683 VEFKSDNTVSKKGFK 697
Score = 128 bits (322), Expect = 9e-29
Identities = 100/391 (25%), Positives = 160/391 (40%), Gaps = 52/391 (13%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
CG G SP +P + + C W + + ++F + L S C +
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR--LCWYDY 379
Query: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923
V+V G L CG+ P P+++ + F+S +GF A + + CG +
Sbjct: 380 VEVRDGFWR-KAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
Query: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
G+I SPNYP Y + C + I+ + V LTF SF +E SC D +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----SCAYDYLE 494
Query: 2984 IIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKF------------ 3030
+ G+S ST CG E P + + + + L F S+ I GF
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 3031 --------------SYRI----------------ISCGGVFNFSSGIITSPAYSYADYPN 3060
SY+ +CGG +G ITSP + +YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
Query: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
+ +C++ + I L+F F+ + C +D++ + G L GKFCGS++P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
Query: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+ S N+M + FK+D+ + KG+K F L
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL 704
Score = 125 bits (315), Expect = 6e-28
Identities = 101/391 (25%), Positives = 155/391 (39%), Gaps = 55/391 (14%)
Query: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743
Y CG +G +SP YPN Y + HC + G I L F+ D+ C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Query: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803
+D V VR+G ++P+ G++CG+ P I S ++L V F S + G GF+A +
Sbjct: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
Query: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863
CGG D G I+SP++P ++ + C W + H+ ++F +F I D C
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHD-SCAYD 491
Query: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV----- 2917
+++V G E L+ CG P + + S+ F S GF+ +F
Sbjct: 492 YLEVRDGHSE-SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2918 --------------------------------------SRCGSNFTGPSGYIISPNYPKQ 2939
+ CG T +G I SP +PK+
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999
Y N NC + + A + L F F E C D V + G + S C
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDV----CKYDFVEVRSGLTADSKLHGKFC 666
Query: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFK 3029
G E P +T + + F S+ ++ GFK
Sbjct: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Score = 123 bits (309), Expect = 3e-27
Identities = 98/415 (23%), Positives = 171/415 (41%), Gaps = 54/415 (13%)
Query: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Y+ +CG S+G +SP Y Y MHC++ I+V+ + I L F+ D+ S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+DY+ + DG PL G+FCGSK P + S+++ + + F++ S KG+ +
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
CGG + SP+ + Y + C+W I + LTF +F +E
Sbjct: 435 -----CGGDVKKDYGHIQSPNYPDD--YRPSKVCIWRIQVSEGFHVGLTFQSFEIE---R 484
Query: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YDY+++ DG SE++ L G +CG P S+ + L ++F+SD ++ + GF +
Sbjct: 485 HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Query: 3272 TIMDMPCG---------------GTYNATWTP-----------------------QNISS 3293
C G+Y + P +I+S
Sbjct: 545 FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
Query: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
P P C W + +P ++ + + D C ++++++ +
Sbjct: 605 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 3353 FCGRNASAVPVFYSSMSTAMVIFKS-GVVNRNSRMSFTYQIADCNRDYHKAFGNL 3406
FCG + V S + V FKS V++ + + + + D H L
Sbjct: 665 FCG--SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGL 717
Score = 117 bits (293), Expect = 2e-25
Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 4/232 (1%)
Query: 3390 YQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECR 3449
Y+ C + GN SP +P+ Y C ++ I L F SL + S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Query: 3450 NDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPS 3509
D++EVR+G +PL G++CG+ LP P+ S ++ L++ F+S S +G+ ++ +
Sbjct: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
Query: 3510 GCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYL 3569
CGG + D G SP YP Y + C W + G V + F I+ C +YL
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 3570 TLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621
+ DG + SS G YCG + ++S+++++KF +D + + F + +
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKP-DDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 204 bits (519), Expect = 1e-51
Identities = 128/383 (33%), Positives = 179/383 (46%), Gaps = 49/383 (12%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
CG Q +G SP YP+ Y ++ C W I V +++LNFT DL C Y
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
DG R CG +L PIVS+ + L++ F+S + +GF A + CGG +
Sbjct: 382 VRDGFWRKAPLRGRFCG-SKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV- 439
Query: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
+ + SP +P +Y ++ C W IQ H+ L+F FE+ER +CA D++E+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGF-HVGLTFQSFEIERHDSCAYDYLEVRDG 498
Query: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASV---------- 1735
E + L GRYCG + P I S SS L L+FVSD SI+ GF V
Sbjct: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1736 ------------------------------SACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
+ACGG G SPG+P YPPN C+
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
W +V+ R+ L F F+ E + C DFVE+R G A L G++CG+ P +S
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY 678
Query: 1825 GHTLWVRFISDGSGSGTGFQATF 1847
+ + V F SD + S GF+A F
Sbjct: 679 -NNMRVEFKSDNTVSKKGFKAHF 700
Score = 197 bits (502), Expect = 1e-49
Identities = 130/410 (31%), Positives = 192/410 (46%), Gaps = 55/410 (13%)
Query: 1606 SRQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHI 1660
+R ++G AQ R+ ACG L S SSP +P Y + +C W I P I
Sbjct: 303 TRLSKGDIAQARKLYKCPACG-ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPG-EKI 360
Query: 1661 TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDS 1720
L+FT +L RS C D+VE+ DG APLRGR+CG+ +P PI S S L + F S S
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
Query: 1721 SISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSF 1780
+ GF A CGG G SP YPD Y P+ C+W I S G + L+F
Sbjct: 421 NWVGKGFFAVYEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
Query: 1781 ISFQLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGS 1839
SF++E C+ D++E+R+G++ + L+GRYCG P + S LW++F+SDGS +
Sbjct: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS-TSSRLWLKFVSDGSIN 536
Query: 1840 GTGFQATFMKIFGND-------------NIVGTH-------------------------- 1860
GF F K N +G++
Sbjct: 537 KAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLT 596
Query: 1861 ---GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917
G + SP WP+ YP N N W + + + + + E C YD + + G +
Sbjct: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656
Query: 1918 IHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAP 1966
++L G +CG++ E +S N++ F SD+++S KGF +F+ P
Sbjct: 657 ADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRP 706
Score = 192 bits (487), Expect = 7e-48
Identities = 123/384 (32%), Positives = 179/384 (46%), Gaps = 56/384 (14%)
Query: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
CG L +TG+FSSP +PN Y + C+W I PG I L D+ C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
+ G +P + C + PE + ST + L + F++ + G+GF A ++A+ C
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPE---PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---C 435
Query: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
GG + G I SPNYP YR + C W I+V V L F F++E DSC Y
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
DG S + + + R CG E+ + I S+ + L+L+F S S GF F
Sbjct: 496 RDGHSESSTLIGRYCGYEK-PDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
ACGG LT +++SP +P YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWPKEYPP 613
Query: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
N+NC W + A P I+L F FE E + C DFVE+ G D+ L G++CG++ P
Sbjct: 614 NKNCIWQLVA-PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 672
Query: 1704 PITSFSSALTLRFVSDSSISAGGF 1727
ITS + + + F SD+++S GF
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGF 696
Score = 189 bits (479), Expect = 6e-47
Identities = 124/386 (32%), Positives = 181/386 (46%), Gaps = 48/386 (12%)
Query: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
ACGE L +STG SP +PN Y ++C W I V P I L F + L C DY+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
EV D + GR+CG +P + S+ + L + F + S+ +GF YEAI C
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-----C 435
Query: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
D D G SPN+P++Y + CI+RI V G + + F +F +E Y D+LE
Sbjct: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYLE 494
Query: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWD--------- 1159
+RDG E S L+G + G P I S S++LWLKF SD ++GF+ +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188
GS CGG LT +G+ SP +P Y +
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
C W L + L+F F E + C D++ V G +++S L + CG EKP +I
Sbjct: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
Query: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEY 1274
S ++M ++ ++D +GFKA +
Sbjct: 675 TSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 186 bits (471), Expect = 5e-46
Identities = 114/386 (29%), Positives = 185/386 (47%), Gaps = 50/386 (12%)
Query: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
AC + D G F+SP +PN Y + C++RI+V G+ I ++FT+ L + +Y D+
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY-DY 379
Query: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
+E+RDG + K+PL G F GS LP I+S ++LW++F+S GF A ++ CG
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---CG 436
Query: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
G++ G SPNYP Y S C W ++ S G L F+ F +E H +C DYL V
Sbjct: 437 GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVR 496
Query: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY------------ 1274
DG S +S L+ + CG EKP I+S+ +++K +D GF +
Sbjct: 497 DGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNR 556
Query: 1275 ---RQTCENVV--------------------------IVNQTYGILESIGYPNPYSENQH 1305
Q C N + + + G + S G+P Y N++
Sbjct: 557 GGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
Query: 1306 CNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGST 1361
C W + A T ++ F F+ E + C D++E+ G + G++CG + P ++
Sbjct: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
Query: 1362 TSSKLQVLLLTDGVGRREKGFQMQWF 1387
+ ++V +D + KGF+ +F
Sbjct: 677 QYNNMRVEFKSDNTVSK-KGFKAHFF 701
Score = 184 bits (466), Expect = 2e-45
Identities = 117/395 (29%), Positives = 186/395 (47%), Gaps = 49/395 (12%)
Query: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272
K ACG + DS G +SP +P+ Y H C+W ++ P +I L F D+ +
Sbjct: 318 KCPACGETLQ----DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS-LDLYRS 372
Query: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332
C +Y+E+RDG AP+ +FCG+ LP S+ +++ FRS ++ GF A Y
Sbjct: 373 RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
Query: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392
A CGG V G ++S +P YR + C W +Q G ++ ++F+ F ++ C
Sbjct: 433 -AICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
Query: 2393 DFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451
D++E+ D H+ S ++GRYCG PD I ++S+ ++FV+DGS+ +GF + F ++E
Sbjct: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2452 ----------------------------------------CGGDLQGSIGTFTSPNYPNP 2471
CGG L G+ TSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
P + C W++ AP RI+L F+ + C + V V +G+ ++S K C S
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-E 669
Query: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSE 2566
I S N M+V F +D + GF A + S +
Sbjct: 670 KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
Score = 183 bits (465), Expect = 2e-45
Identities = 124/396 (31%), Positives = 184/396 (46%), Gaps = 57/396 (14%)
Query: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
ACG L+ D+ SP +P+ YS + C W I P + LN SLD+ R C YD
Sbjct: 321 ACGETLQ--DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
Query: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
+ +RDG A CG ++P PI ST +++ F S S+ GF A + CGG
Sbjct: 379 YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
Query: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
+ D G I SP YP+ Y + C W + V G + + F Q F+I DS DYL +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDSCAY--DYLEV 495
Query: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
R+G S + G +CG + ++ ++++++F+SD S GF + +
Sbjct: 496 RDGHSESSTLI------GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
Query: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
E + L ACGG + G +TSP
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL----TKLNGSITSP 605
Query: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
P YPP+ +CIW L AP + RI LQF D F+ E C +++E+R G+ +D+ + K
Sbjct: 606 GWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
FCG+ P S M + F+SDN+ + GFKA +
Sbjct: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 183 bits (464), Expect = 3e-45
Identities = 119/416 (28%), Positives = 181/416 (43%), Gaps = 55/416 (13%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CG L S+G F SP YP Y C W + + G L F L C DY+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
V DG + L + CG + P I S+ ++++ R+ G+GF A Y C V
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV-- 439
Query: 1285 NQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP 1344
+ YG ++S YP+ Y ++ C W I+ + G V TF +F++E H +C+ DYLE+ DG
Sbjct: 440 KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGH 499
Query: 1345 RQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVY----------- 1389
+ +GRYCG + P +TSS+L + ++DG + GF + +F
Sbjct: 500 SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDG-SINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1390 -------------------------------GCGGELSGATGSFSSPGFPNRYPPNKECI 1418
CGG L+ GS +SPG+P YPPNK CI
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
Query: 1419 WYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVS 1478
W + I L F+ E + C +D +E+ G S + C PE ++
Sbjct: 619 WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE---VIT 675
Query: 1479 STGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNT 1534
S N + + FK+D +++ +GF A + + Q P G H + R+ T
Sbjct: 676 SQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPA---LQPPRGRPHQLKFRVQKRNRT 728
Score = 182 bits (461), Expect = 7e-45
Identities = 126/395 (31%), Positives = 180/395 (45%), Gaps = 48/395 (12%)
Query: 807 ASFRAVYQV-ACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
A R +Y+ ACG+ L G SP +PN Y C W I + I+LNFT ++
Sbjct: 311 AQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY 370
Query: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
S C DYVE+ +P ++CG+ +P I S + L+V F SS+ GF A
Sbjct: 371 RSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
Query: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
+ A CG + + G IQSP +P+ Y C W I V + L F++F +E H +
Sbjct: 431 YEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
Query: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
C DYLEV D SE+S +GRYCG P + S+ + L L FV+D + GF +N+
Sbjct: 488 CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547
Query: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
+ AC T G+ TSP +
Sbjct: 548 VDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGW 607
Query: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLE-EAIGNYYTDFLEIRDGGYEKSPLLGIF 1123
P YP N CI+++ T I++ F F E + Y DF+E+R G S L G F
Sbjct: 608 PKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY--DFVEVRSGLTADSKLHGKF 665
Query: 1124 YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
GS P I S N + ++FKSD ++ GF A++
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 179 bits (454), Expect = 4e-44
Identities = 128/397 (32%), Positives = 181/397 (45%), Gaps = 36/397 (9%)
Query: 1737 ACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFV 1796
ACG T + G F+SP YP+ Y ++ CVW I +PG ++ L+F S L S+ C D+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 1797 EIREGN-ATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDN 1855
E+R+G L GR+CG+ P S LWV F S + G GF A + I G D
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVS-TDSRLWVEFRSSSNWVGKGFFAVYEAICGGD- 438
Query: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
+ +G + SP +P++Y + W + V+ V +IE +C YD L + DG
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG 498
Query: 1916 PSIHARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA-VD--------- 1964
S + LIG YCG + + ST + L F SD SI+ GF + +F VD
Sbjct: 499 HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
Query: 1965 APDGVLPTIA-------PG------------ACGGFLRTGDAPVFLFSPGWPDSYSNRVD 2005
L T+ PG ACGGFL + + SPGWP Y +
Sbjct: 559 CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSIT--SPGWPKEYPPNKN 616
Query: 2006 CTWLIQAPDS-TVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRS 2064
C W + AP + L + E + C YD + +R G ++ CG E P I S
Sbjct: 617 CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
Query: 2065 TGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADRG 2101
M + F SD++V++ GF A F L RG
Sbjct: 677 QYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
Score = 171 bits (433), Expect = 1e-41
Identities = 109/389 (28%), Positives = 166/389 (42%), Gaps = 53/389 (13%)
Query: 588 PECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDY 647
P CG L G+ SP YP Y CVW + +P + F +L L C DY
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDY 379
Query: 648 LEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLR 707
+E+RDG + PL G+FC + P+ +T + F S S +GF Y +
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY-----EAI 434
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CGG+ G + P + ++ C++ ++ +G + + F E++ + +Y+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 768 VRDGE----TLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY---------- 813
VRDG TL+G+ CG IKS ++ +W++F D S+ KA F +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 814 ---------------------------------QVACGDELTG-EGVIRSPFFPNVYPGE 839
+ ACG LT G I SP +P YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 840 RTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFI 899
+ C W + P I L F FE + C+ D+VE+ S S + K+CG++ P I
Sbjct: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
Query: 900 TSVYNFLYVTFVKSSSTENHGFMAKFSAE 928
TS YN + V F ++ GF A F +E
Sbjct: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSE 703
Score = 171 bits (432), Expect = 2e-41
Identities = 118/410 (28%), Positives = 178/410 (43%), Gaps = 49/410 (11%)
Query: 448 VDGVDSFSCECTRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWV 503
V+GV + TRL G + Q + CGE+L G+FS GY ++C W
Sbjct: 292 VNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWR 351
Query: 504 IKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNA 563
I G+ + + FT L C +++++V DG A GRFCGS LP ++S+D+
Sbjct: 352 ISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSR 411
Query: 564 LYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTS 623
L+ S G+GF +E CGG + YG I+SP YP +Y P + C+W + S
Sbjct: 412 LWVEFRSSSNWVGKGFFAVYEAI---CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVS 468
Query: 624 PDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIH 683
V TF + +E HD C DYLE+RDG L+G++C +++T +
Sbjct: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
Query: 684 FHSDSQISDQGFHIT----------------------------------YLTSPSDLR-- 707
F SD I+ GF + Y +P R
Sbjct: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
Query: 708 --CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
CGG T G + P + + C++ + P +I + F E + ++
Sbjct: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
Query: 766 IEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRA 811
+EVR G T L GK CG+ I S N++ + FK D +V K F+A
Sbjct: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
Score = 169 bits (428), Expect = 5e-41
Identities = 124/403 (30%), Positives = 179/403 (44%), Gaps = 54/403 (13%)
Query: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQDC 2628
CG +L ++ GNF+SP Y YS +++C W +S P + I ++F L + C
Sbjct: 322 CGETLQDST-GNFSSPEYPN--GYSAHMHCVWRISVTPGE---KIILNFTSLDLYRSRLC 375
Query: 2629 QFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT 2687
+D +E R G PL R CG P P+V S++W+ F ++ GF A Y
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
Query: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747
CGG D G I SPNYP+ Y C ++ +G + LTF F+IE H +CA+D +
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 2748 TVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ------ 2801
VR+G S S +IG+YCG P I+S S++L + F SD S+ GF + +
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 2802 ------------TLG----------------------CGGIFHSDNGTIRSPHWPQNFPE 2827
TLG CGG NG+I SP WP+ +P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 2828 NSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVA 2887
N C W + + + FD F G+ C+ FV+V +G D L CG+
Sbjct: 614 NKNCIWQLVAPTQYRISLQFD--FFETEGNDVCKYDFVEVRSGL-TADSKLHGKFCGSEK 670
Query: 2888 PGPVITPSNTFTAVFQSQEAPA-QGFSASFVSRCGSNFTGPSG 2929
P + + N F+S + +GF A F S P G
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
Score = 163 bits (413), Expect = 3e-39
Identities = 115/390 (29%), Positives = 174/390 (44%), Gaps = 49/390 (12%)
Query: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979
CG +G SP YP Y +M+C + I P ++L F S L RS + C
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY-RSRL---CWY 377
Query: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038
D V + G+ + CG ++P P+ L + F S+ GF Y I CG
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
Query: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098
G G I SP Y DY C++ I VS+ + L F F++ SC++DYL +
Sbjct: 437 GDVKKDYGHIQSPNYP-DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
Query: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF----------- 3147
DG + S L+G++CG ++P ++KS+++ + L F +D G+ ++F
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
Query: 3148 --------RQTLGP------------------QQGCGGYLTGSNNTFASPDSDSNGMYDK 3181
TLG + CGG+LT N + SP Y
Sbjct: 556 RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE--YPP 613
Query: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241
N NC+W ++AP I L F+ F E C YD+V++ G + ++ L G FCGS
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDV---CKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 3242 PAPFISSGNFLTVQFISDLTLEREGFNATY 3271
P S N + V+F SD T+ ++GF A +
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 160 bits (405), Expect = 2e-38
Identities = 112/380 (29%), Positives = 163/380 (42%), Gaps = 62/380 (16%)
Query: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----P 1344
G S YPN YS + HC W I T G + F + DL C DY+E+ DG
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
Query: 1345 RQMGRYCGVDLPPPGSTTSSKLQVLLLTDG--VGRREKGFQMQWFVYG--CGGELSGATG 1400
GR+CG LP P +T S+L V + VG KGF + VY CGG++ G
Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVG---KGF---FAVYEAICGGDVKKDYG 444
Query: 1401 SFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSP 1460
SP +P+ Y P+K CIW I+ G + LT F++E H C +D LE+ G S
Sbjct: 445 HIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESST 504
Query: 1461 RIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASW----------------- 1503
I + C P++ + ST + L ++F +D SIN GF ++
Sbjct: 505 LIGRYCGYEKPDD---IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
Query: 1504 -----------------------QAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVI 1540
+ CGG +G I SP +P Y N +C W +
Sbjct: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 1541 RVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNS 1596
+R+ L F F+ E D C + GL++ + CG E+ I S N+
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK-PEVITSQYNN 680
Query: 1597 LFLRFQSGPSRQNRGFRAQF 1616
+ + F+S + +GF+A F
Sbjct: 681 MRVEFKSDNTVSKKGFKAHF 700
Score = 159 bits (402), Expect = 5e-38
Identities = 105/379 (27%), Positives = 163/379 (43%), Gaps = 47/379 (12%)
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CG D G PE ++ CV+ + GE+I +NFT ++L +Y+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 768 VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823
VRDG L G+ CG+ I S + +W+ F+ ++ F AVY+ CG ++
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
Query: 824 E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882
+ G I+SP +P+ Y + C W I + + L F FEI C DY+E+
Sbjct: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
Query: 883 GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928
S +YCG + P I S + L++ FV S GF F E
Sbjct: 502 SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
Query: 929 --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962
+ ACG LT+ G+I SPG P YP NC W +
Sbjct: 562 RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 963 LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSL 1020
+ + I L F+ F E + C D++EV T G++CG P +TS N++
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNM 681
Query: 1021 MLVFVTDSDLAYEGFLINY 1039
+ F +D+ ++ +GF ++
Sbjct: 682 RVEFKSDNTVSKKGFKAHF 700
Score = 157 bits (396), Expect = 2e-37
Identities = 111/395 (28%), Positives = 173/395 (43%), Gaps = 70/395 (17%)
Query: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
G +SP +P Y + + W ++V + +D+ + C+YD + + DG A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
Query: 1921 RLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACG 1979
L G +CG++ E ST + L F S S+ GKGF + A+ CG
Sbjct: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI--------------CG 436
Query: 1980 GFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLV 2038
G ++ + SP +PD Y C W IQ + V L S +IE H +CAYD L
Sbjct: 437 GDVKKDYGHIQ--SPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 2039 IRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK-------- 2090
+RDG + + + CG E P I+ST ++++F SD S+ +AGF +F K
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 2091 -----------------------------------SCGGYLHADRGIITSPKYPETYPSN 2115
+CGG+L G ITSP +P+ YP N
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
Query: 2116 LNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHF 2175
NC W ++ + I++ F+ F G+ C D++ +R+G S +G F
Sbjct: 615 KNCIWQLVAPTQYRISLQFD--FFETEGNDVCKY-DFVEVRSGLTADSKL------HGKF 665
Query: 2176 CGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
CGS + + N M V+F SD++ +GFK +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 155 bits (392), Expect = 7e-37
Identities = 110/387 (28%), Positives = 171/387 (44%), Gaps = 53/387 (13%)
Query: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVW-IIIAPVNKVIHLTFNTFALEAASTRQRC 3215
CG L S F+SP+ + Y +++CVW I + P K+I L F + L + + C
Sbjct: 322 CGETLQDSTGNFSSPEYPNG--YSAHMHCVWRISVTPGEKII-LNFTSLDLYRS---RLC 375
Query: 3216 LYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275
YDYV++ DG A L G FCGS +P P +S+ + L V+F S +GF A Y +
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQ 3334
CGG + +I SPN D P +C W I V +T + ++ D C
Sbjct: 435 --CGGDVKKDY--GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
Query: 3335 NYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIAD 3394
+YL+++D ++CG SS + + ++F ++ +
Sbjct: 491 DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 3395 CNRDYH----------------------------------------KAFGNLRSPGWPDN 3414
C+R K G++ SPGWP
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 3415 YDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLL 3474
Y +K+C L AP + ISL F E + C+ DF+EVR+G ++S L GK+CG+
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 3475 PNPVFSQNNELYLRFKSDSVTSDRGYE 3501
P + SQ N + + FKSD+ S +G++
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFK 697
Score = 148 bits (373), Expect = 1e-34
Identities = 105/395 (26%), Positives = 171/395 (43%), Gaps = 52/395 (13%)
Query: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Y CG + +G S +P Y ++ C W + G + ++F +L S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPN-GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
D+VE+ D + GR+CG+ +P+ I ++ + V F + + GF +E+
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
CGGD++ G SPNYP+ ++C WRI EG + L F + + H SC ++
Sbjct: 435 --CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
Query: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
+ V +G +S + + C ++IKS+ + + + F +DGS GF ++ D
Sbjct: 493 LEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
Query: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
A CGG L G+ TSPG+
Sbjct: 552 SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NGSITSPGWP-- 608
Query: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
+ Y N NC W L P Q IS+ F+ F E + C++D +E R G AD L + C
Sbjct: 609 KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
G KP + + Y+ + + F ++ V GF A +
Sbjct: 667 GSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 148 bits (373), Expect = 1e-34
Identities = 110/388 (28%), Positives = 167/388 (43%), Gaps = 54/388 (13%)
Query: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
CG LQ S G F+SP YPN C WRI+ G +I L F +L L C ++V
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCG 2571
V +G +P + C S + I S+ + + V F + + GF A Y +A+CG
Sbjct: 382 VRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----EAICG 436
Query: 2572 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD 2631
G + G+ SP Y +Y + C W + + + F+ F +E H C +D
Sbjct: 437 GDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCAYD 491
Query: 2632 VLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------ 2684
LE R G ++ L+ R CG KP + S++W+ FV++ + GF +
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2685 ------------------------------------SFTDCGGIQIGDSGVITSPNYPNA 2708
CGG +G ITSP +P
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2709 YDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Y +C L AP + I+L F F+ E + C +D V VR+G + +S + G++CG+
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
Query: 2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYA 2796
P I S N + V F SD+++ GF A
Sbjct: 671 PEVITSQYNNMRVEFKSDNTVSKKGFKA 698
Score = 137 bits (344), Expect = 3e-31
Identities = 104/375 (27%), Positives = 163/375 (43%), Gaps = 54/375 (14%)
Query: 3292 SSPNSSDPDVPFSI-----CTWVIDSPPHQQVKITVWALQL-TSQDCTQNYLQLQDSPQG 3345
S+ N S P+ P C W I P +++ + +L L S+ C +Y++++D
Sbjct: 329 STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWR 388
Query: 3346 HGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGN 3405
R +FCG V S+ S V F+S N + F A C D K +G+
Sbjct: 389 KAPLRGRFCGSKLPEPIV--STDSRLWVEFRSSS-NWVGKGFFAVYEAICGGDVKKDYGH 445
Query: 3406 LRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPL 3465
++SP +PD+Y K C + + + L F S IE C D+LEVR+G + +S L
Sbjct: 446 IQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTL 505
Query: 3466 LGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY------EIIWTSSP----------- 3508
+G+YCG P+ + S ++ L+L+F SD + G+ E+ S P
Sbjct: 506 IGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLN 565
Query: 3509 -----------------------SGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPA 3545
+ CGG L GS TSPG+P YP N C W LVAP
Sbjct: 566 TLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPT 625
Query: 3546 GRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASS--NQVF 3603
+++ F F + C +++ + G A S G +CG + P V +S N +
Sbjct: 626 QYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSE---KPEVITSQYNNMR 682
Query: 3604 IKFHADYARRPSAFR 3618
++F +D F+
Sbjct: 683 VEFKSDNTVSKKGFK 697
Score = 129 bits (325), Expect = 4e-29
Identities = 103/400 (25%), Positives = 164/400 (41%), Gaps = 56/400 (14%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
CG G SP +P + + C W + + ++F + L S C +
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR--LCWYDY 379
Query: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923
V+V G L CG+ P P+++ + F+S +GF A + + CG +
Sbjct: 380 VEVRDGFWR-KAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
Query: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
G+I SPNYP Y + C + I+ + V LTF SF +E SC D +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----SCAYDYLE 494
Query: 2984 IIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKF------------ 3030
+ G+S ST CG E P + + + + L F S+ I GF
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 3031 --------------SYRI----------------ISCGGVFNFSSGIITSPAYSYADYPN 3060
SY+ +CGG +G ITSP + +YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
Query: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
+ +C++ + I L+F F+ + C +D++ + G L GKFCGS++P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
Query: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSF----RQTLGPQQG 3156
+ S N+M + FK+D+ + KG+K F R L P +G
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713
Score = 125 bits (315), Expect = 6e-28
Identities = 101/391 (25%), Positives = 155/391 (39%), Gaps = 55/391 (14%)
Query: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743
Y CG +G +SP YPN Y + HC + G I L F+ D+ C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Query: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803
+D V VR+G ++P+ G++CG+ P I S ++L V F S + G GF+A +
Sbjct: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
Query: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863
CGG D G I+SP++P ++ + C W + H+ ++F +F I D C
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHD-SCAYD 491
Query: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV----- 2917
+++V G E L+ CG P + + S+ F S GF+ +F
Sbjct: 492 YLEVRDGHSE-SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 2918 --------------------------------------SRCGSNFTGPSGYIISPNYPKQ 2939
+ CG T +G I SP +PK+
Sbjct: 551 CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
Query: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999
Y N NC + + A + L F F E C D V + G + S C
Sbjct: 611 YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDV----CKYDFVEVRSGLTADSKLHGKFC 666
Query: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFK 3029
G E P +T + + F S+ ++ GFK
Sbjct: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Score = 122 bits (306), Expect = 6e-27
Identities = 94/385 (24%), Positives = 161/385 (41%), Gaps = 53/385 (13%)
Query: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Y+ +CG S+G +SP Y Y MHC++ I+V+ + I L F+ D+ S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
Query: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
+DY+ + DG PL G+FCGSK P + S+++ + + F++ S KG+ +
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
Query: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
CGG + SP+ + Y + C+W I + LTF +F +E
Sbjct: 435 -----CGGDVKKDYGHIQSPNYPDD--YRPSKVCIWRIQVSEGFHVGLTFQSFEIE---R 484
Query: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YDY+++ DG SE++ L G +CG P S+ + L ++F+SD ++ + GF +
Sbjct: 485 HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Query: 3272 TIMDMPCG---------------GTYNATWTP-----------------------QNISS 3293
C G+Y + P +I+S
Sbjct: 545 FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
Query: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
P P C W + +P ++ + + D C ++++++ +
Sbjct: 605 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
Query: 3353 FCGRNASAVPVFYSSMSTAMVIFKS 3377
FCG + V S + V FKS
Sbjct: 665 FCG--SEKPEVITSQYNNMRVEFKS 687
Score = 117 bits (293), Expect = 2e-25
Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 4/232 (1%)
Query: 3390 YQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECR 3449
Y+ C + GN SP +P+ Y C ++ I L F SL + S C
Sbjct: 317 YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
Query: 3450 NDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPS 3509
D++EVR+G +PL G++CG+ LP P+ S ++ L++ F+S S +G+ ++ +
Sbjct: 377 YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
Query: 3510 GCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYL 3569
CGG + D G SP YP Y + C W + G V + F I+ C +YL
Sbjct: 435 -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
Query: 3570 TLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621
+ DG + SS G YCG + ++S+++++KF +D + + F + +
Sbjct: 494 EVRDGHSESSTLIGRYCGYEKP-DDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 63.9 bits (154), Expect = 3e-09
Identities = 43/167 (25%), Positives = 77/167 (46%), Gaps = 10/167 (5%)
Query: 427 VNCTENINECLSNPCLNG--GTCVDGVDSFSCECTRLWTGA----LCQVPQQVCGESLSG 480
VN + ++EC S P G C++ + S+ C C + A C+ CG L+
Sbjct: 542 VNFFKEVDEC-SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA---ACGGFLTK 597
Query: 481 INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS 540
+NGS + Y + NC W + + + F FF E D C ++F++V G ++
Sbjct: 598 LNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTA 657
Query: 541 SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQ 587
+ G+FCGS P + S N + S++ + +GF + +++
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 202 bits (513), Expect = 6e-51
Identities = 136/392 (34%), Positives = 183/392 (46%), Gaps = 63/392 (16%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F G V+ C S+ CQNGGTC + D++ C+CP W G CS DV+ECE P
Sbjct: 268 FIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQG--PPH 325
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVA---RCVHGI----------- 229
C+NGGTC N+ GS+ C C G C DDC + A C+ +
Sbjct: 326 CRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGR 385
Query: 230 ------CEDLMREQA--GEPKYS---------CVCDAGWMFSPNSPACTLDRDECSFQ-- 270
ED+ Q G+ + S C+C G+ + P C D DEC
Sbjct: 386 TGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGY----SGPTCHQDLDECLMAQQ 441
Query: 271 -PGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINNGGCSVAPPVECVNTP 328
P PC C NT GSF C CP G+ G+ CE D NEC P C++
Sbjct: 442 GPSPCEHGGSCLNTPGSFNC-LCPPGYTGSR--CEADHNECLSQ----PCHPGSTCLDLL 494
Query: 329 GSSHCQACPPGYQGDGRVCTL-TDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGY 387
+ HC CPPG +G++C + T+ C ++ C A C L C CLPG++G
Sbjct: 495 ATFHC-LCPPGL--EGQLCEVETNEC--ASAPCLNHADCHDLLNGFQ-CICLPGFSG--- 545
Query: 388 GPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGT 446
C + + C S PC N GQC D + CKC G+ G C ++ECLS+PC G +
Sbjct: 546 --TRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGAS 603
Query: 447 CVDGVDSFSCECTRLWTGALCQVPQQVCGESL 478
C+D +F C C +TG LC+VP +C +L
Sbjct: 604 CLDLPGAFFCLCPSGFTGQLCEVP--LCAPNL 633
Score = 198 bits (503), Expect = 9e-50
Identities = 132/387 (34%), Positives = 170/387 (43%), Gaps = 71/387 (18%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
CS+NPC NGG CL + C CPP ++G C DVNEC P C G +C NT+G
Sbjct: 160 CSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNEC---FQDPGPCPKGTSCHNTLG 216
Query: 196 SYSCHCPPETYGPQCASKYDDC------EGGSVA-------------------------- 223
S+ C CP GP+C + C GG+
Sbjct: 217 SFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVN 276
Query: 224 --RCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQ-PGPCSTLVQC 280
CV C++ Q G Y+C+C W C+ D DEC Q P C C
Sbjct: 277 PDNCVSHQCQNGGTCQDGLDTYTCLCPETW----TGWDCSEDVDECETQGPPHCRNGGTC 332
Query: 281 FNTQGSFYCGACPTGWQGNGYICEDINECEINNGGC---SVAPPVECVNTPGSSHCQACP 337
N+ GSF+C C +GW G CE N C + AP C++ GS C CP
Sbjct: 333 QNSAGSFHC-VCVSGWGG--------TSCEENLDDCIAATCAPGSTCIDRVGSFSC-LCP 382
Query: 338 PGYQGDGRVCTLTDICSVSNGGCHPDASCSST-LGSLPLCTCLPGYTGNGYGPNGCVQLS 396
PG G +C L D+C + CH DA CS+ L LC C PGY+G C Q
Sbjct: 383 PG--RTGLLCHLEDMC--LSQPCHGDAQCSTNPLTGSTLCLCQPGYSG-----PTCHQDL 433
Query: 397 NICL-----SHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDG 450
+ CL PC + G C++T + C C G+TG C + NECLS PC G TC+D
Sbjct: 434 DECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDL 493
Query: 451 VDSFSCECTRLWTGALCQVPQQVCGES 477
+ +F C C G LC+V C +
Sbjct: 494 LATFHCLCPPGLEGQLCEVETNECASA 520
Score = 175 bits (443), Expect = 8e-43
Identities = 115/361 (31%), Positives = 165/361 (45%), Gaps = 58/361 (16%)
Query: 139 NPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYS 198
+PC++GG+CLN SF C+CPP + G C AD NEC C G TC++ + ++
Sbjct: 444 SPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNEC-----LSQPCHPGSTCLDLLATFH 498
Query: 199 CHCPPETYGPQCASKYDDCEGGSVARCV-HGICEDLMREQAGEPKYSCVCDAGWMFSPNS 257
C CPP G C + ++C A C+ H C DL+ + C+C G+ +
Sbjct: 499 CLCPPGLEGQLCEVETNECAS---APCLNHADCHDLLNG------FQCICLPGF----SG 545
Query: 258 PACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINNGGC 316
C D DEC + PC+ QC + G+F+C P G++G C+ +++EC + C
Sbjct: 546 TRCEEDIDEC--RSSPCANGGQCQDQPGAFHCKCLP-GFEGPR--CQTEVDECL--SDPC 598
Query: 317 SVAPPVECVNTPGSSHCQACPPGYQGD--------GRVCTLTDICSV------------S 356
V C++ PG+ C CP G+ G +C IC S
Sbjct: 599 PVG--ASCLDLPGAFFC-LCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGS 655
Query: 357 NGGCHPDASCSSTLGSLPL--CTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDTV 413
G P+ +C+ G C C G+TG P +L C+S PC +G C
Sbjct: 656 PGCAPPEDNCTCHHGHCQRSSCVCDVGWTG----PECEAELGG-CISAPCAHGGTCYPQP 710
Query: 414 SGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQV 473
SGY C C +G+TG C+E + C S PCLNGG+C + C C TG CQ
Sbjct: 711 SGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDY 770
Query: 474 C 474
C
Sbjct: 771 C 771
Score = 171 bits (434), Expect = 9e-42
Identities = 116/370 (31%), Positives = 154/370 (41%), Gaps = 58/370 (15%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
+ G + D C S PC G TCL+L +F C+CPP +G LC + NEC
Sbjct: 467 YTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC-----ASAP 521
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C N C + + + C C P G +C D+C A G C+D Q G +
Sbjct: 522 CLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCAN--GGQCQD----QPGA--F 573
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN---- 299
C C G+ P C + DEC P C C + G+F+C CP+G+ G
Sbjct: 574 HCKCLPGF----EGPRCQTEVDECLSDP--CPVGASCLDLPGAFFC-LCPSGFTGQLCEV 626
Query: 300 ----------GYICEDINE---CEINNGGCSVAPPVECVNTPGSSHCQ----ACPPGYQG 342
IC+D + C +G APP + T HCQ C G+ G
Sbjct: 627 PLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNC-TCHHGHCQRSSCVCDVGWTG 685
Query: 343 DGRVCTLTDICSVS---NGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNIC 399
L S G C+P S + CTC GYTG C + C
Sbjct: 686 PECEAELGGCISAPCAHGGTCYPQPSGYN-------CTCPTGYTGPT-----CSEEMTAC 733
Query: 400 LSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
S PCLNG C + GY+C C TG C + + C+S PC NGGTCV+ +FSC C
Sbjct: 734 HSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLC 793
Query: 459 TRLWTGALCQ 468
+ G C+
Sbjct: 794 AMGFQGPRCE 803
Score = 161 bits (408), Expect = 1e-38
Identities = 109/356 (30%), Positives = 150/356 (42%), Gaps = 55/356 (15%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C S PC NGG+C ++C CPP GP C + C C NGGTCVN G
Sbjct: 733 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYC-----VSAPCFNGGTCVNRPG 787
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
++SC C GP+C EG C C + Q C+C G+
Sbjct: 788 TFSCLCAMGFQGPRC-------EGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGY---- 836
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECE---- 310
+C D C+ +P P ++ C T SF+C C GW G +C ++ C+
Sbjct: 837 TGGSCQTLMDLCAQKPCPRNS--HCLQTGPSFHC-LCLQGWTGP--LCNLPLSSCQKAAL 891
Query: 311 ---------INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCH 361
+NGG CV++ S C CPPG+QG +C + + C
Sbjct: 892 SQGIDVSSLCHNGGL-------CVDSGPSYFCH-CPPGFQGS--LCQ-DHVNPCESRPCQ 940
Query: 362 PDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKC 420
A+C + LC C PGY G C + + C S PC N G C G+ C C
Sbjct: 941 NGATCMAQPSGY-LCQCAPGYDGQN-----CSKELDACQSQPCHNHGTCTPKPGGFHCAC 994
Query: 421 DSGWTGVNCTENINECLSNPCLNGGT--CVDGVDSFSCECTRLWTGALCQVPQQVC 474
G+ G+ C +++ECL PC GT C ++F C+C TG C+V C
Sbjct: 995 PPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPC 1050
Score = 155 bits (391), Expect = 9e-37
Identities = 112/357 (31%), Positives = 149/357 (41%), Gaps = 59/357 (16%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C S PC +GGTC + C CP + GP CS ++ C +SG C NGG+C + G
Sbjct: 695 CISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTAC--HSGP---CLNGGSCNPSPG 749
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
Y C CPP GPQC + D C A C +G + G +SC+C G+
Sbjct: 750 GYYCTCPPSHTGPQCQTSTDYCVS---APCFNG---GTCVNRPGT--FSCLCAMGFQ--- 798
Query: 256 NSPACTLD-RDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNG 314
P C R C+ PC C ++ C CPTG+ G C+
Sbjct: 799 -GPRCEGKLRPSCA--DSPCRNRATCQDSPQGPRC-LCPTGYTGGS--------CQTLMD 846
Query: 315 GCSVAP---PVECVNTPGSSHCQACPPGYQGDGRVCTLT-------------DICSVSNG 358
C+ P C+ T S HC C G+ G +C L D+ S+
Sbjct: 847 LCAQKPCPRNSHCLQTGPSFHC-LCLQGWTGP--LCNLPLSSCQKAALSQGIDVSSL--- 900
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYF 417
CH C + G C C PG+ G+ C N C S PC NG C+ SGY
Sbjct: 901 -CHNGGLCVDS-GPSYFCHCPPGFQGSL-----CQDHVNPCESRPCQNGATCMAQPSGYL 953
Query: 418 CKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
C+C G+ G NC++ ++ C S PC N GTC F C C + G C+ C
Sbjct: 954 CQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDEC 1010
Score = 148 bits (373), Expect = 1e-34
Identities = 113/368 (30%), Positives = 145/368 (39%), Gaps = 66/368 (17%)
Query: 141 CQNGGTCLNL--------------HDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQN 186
CQNGG+C L SF C C P + G C A + + P C
Sbjct: 74 CQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED----PCPPSFCSK 129
Query: 187 GGTC-VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYS 244
G C + G C C P G QC + D C S CV+G +C A P+
Sbjct: 130 RGRCHIQASGRPQCSCMPGWTGEQCQLR-DFC---SANPCVNGGVC------LATYPQIQ 179
Query: 245 CVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE 304
C C G+ AC D +EC PGPC C NT GSF C CP G +G
Sbjct: 180 CHCPPGF----EGHACERDVNECFQDPGPCPKGTSCHNTLGSFQC-LCPVGQEGP----- 229
Query: 305 DINECEINNGGCSVAPPVECVN---------TPGSSHCQACPPGYQGDGRVCTLTDICSV 355
CE+ G C PP C N + H CPPG+ G C V
Sbjct: 230 ---RCELRAGPC---PPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPD--------CEV 275
Query: 356 SNGGC--HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDT 412
+ C H + + L TCL T G+ + V C NG C ++
Sbjct: 276 NPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNS 335
Query: 413 VSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQ 472
+ C C SGW G +C EN+++C++ C G TC+D V SFSC C TG LC +
Sbjct: 336 AGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM 395
Query: 473 VCGESLSG 480
+ G
Sbjct: 396 CLSQPCHG 403
Score = 147 bits (371), Expect = 2e-34
Identities = 128/397 (32%), Positives = 164/397 (41%), Gaps = 82/397 (20%)
Query: 135 VCSS--NPCQNGGTCLNLH-DSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCV 191
+C S PC NGGTCL+L C C P + G C + C+ CQNGG+C
Sbjct: 27 LCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQ----NAQLCQNGGSCQ 81
Query: 192 NTM--------------GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMR-- 235
+ S+ C C P G +C +K +D C C R
Sbjct: 82 ALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED-------PCPPSFCSKRGRCH 134
Query: 236 -EQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPT 294
+ +G P+ C C GW C L RD CS PC C T C CP
Sbjct: 135 IQASGRPQ--CSCMPGW----TGEQCQL-RDFCS--ANPCVNGGVCLATYPQIQC-HCPP 184
Query: 295 GWQGNGYICE-DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDIC 353
G++ G+ CE D+NEC + G C C NT GS C CP G +G C
Sbjct: 185 GFE--GHACERDVNECFQDPGPCPKG--TSCHNTLGSFQC-LCPVGQEGPR--------C 231
Query: 354 SVSNGGCHPDASCSS--TLGSLP-------LCTCLPGYTGNGYGPNGCVQLSNICLSHPC 404
+ G C P CS+ T +P LC C PG+ GP+ V N C+SH C
Sbjct: 232 ELRAGPC-PPRGCSNGGTCQLMPEKDSTFHLCLCPPGF----IGPDCEVNPDN-CVSHQC 285
Query: 405 LN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSN---PCLNGGTCVDGVDSFSCECTR 460
N G C D + Y C C WTG +C+E+++EC + C NGGTC + SF C C
Sbjct: 286 QNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVS 345
Query: 461 LWTGALCQVPQQVC-------GESLSGINGSFSYRSP 490
W G C+ C G + GSFS P
Sbjct: 346 GWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCP 382
Score = 145 bits (365), Expect = 9e-34
Identities = 113/433 (26%), Positives = 154/433 (35%), Gaps = 123/433 (28%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F+G + + C S+PC G +CL+L +FFC+CP + G LC E+ P
Sbjct: 581 FEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLC-------EVPLCAPNL 633
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
CQ C + +C CP + P CA D+C C HG C+ +
Sbjct: 634 CQPKQICKDQKDKANCLCPDGS--PGCAPPEDNCT------CHHGHCQ----------RS 675
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG----- 298
SCVCD GW P C + C PC+ C+ + C CPTG+ G
Sbjct: 676 SCVCDVGW----TGPECEAELGGCI--SAPCAHGGTCYPQPSGYNC-TCPTGYTGPTCSE 728
Query: 299 --------------------NGYIC-----EDINECEINNGGCSVAPPVE---CVNTPGS 330
GY C +C+ + C AP CVN PG+
Sbjct: 729 EMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGT 788
Query: 331 SHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN 390
C C G+QG L C+ S C A+C + P C C GYTG
Sbjct: 789 FSC-LCAMGFQGPRCEGKLRPSCADSP--CRNRATCQDSPQG-PRCLCPTGYTGGS---- 840
Query: 391 GCVQLSNICLSHPCLN-------------------------------------------- 406
C L ++C PC
Sbjct: 841 -CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSS 899
Query: 407 -----GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRL 461
G C+D+ YFC C G+ G C +++N C S PC NG TC+ + C+C
Sbjct: 900 LCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPG 959
Query: 462 WTGALCQVPQQVC 474
+ G C C
Sbjct: 960 YDGQNCSKELDAC 972
Score = 137 bits (345), Expect = 2e-31
Identities = 114/371 (30%), Positives = 154/371 (41%), Gaps = 59/371 (15%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECE---IYSGTPLS--CQNGGT 189
+C+ PC CL SF C+C W GPLC+ ++ C+ + G +S C NGG
Sbjct: 847 LCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906
Query: 190 CVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDA 249
CV++ SY CHCPP G C + CE C +G M + +G Y C C
Sbjct: 907 CVDSGPSYFCHCPPGFQGSLCQDHVNPCESRP---CQNGAT--CMAQPSG---YLCQCAP 958
Query: 250 GWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINE 308
G+ + C+ + D C QP C C G F+C ACP G+ G CE D++E
Sbjct: 959 GY----DGQNCSKELDACQSQP--CHNHGTCTPKPGGFHC-ACPPGFVG--LRCEGDVDE 1009
Query: 309 CEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPD----- 363
C + C C + + +CQ C PG+ G C V CH
Sbjct: 1010 CL--DQPCHPTGTAACHSLANAFYCQ-CLPGHTGQW--------CEVEIDPCHSQPCFHG 1058
Query: 364 ASCSSTLGSLPL---CTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYF-- 417
+C +T GS PL C C G+ G C + C H C +G C+ + F
Sbjct: 1059 GTCEATAGS-PLGFICHCPKGFEGPT-----CSHRAPSCGFHHCHHGGLCLPSPKPGFPP 1112
Query: 418 -CKCDSGWTGVNCTENI--NEC-LSNPCLNGGTCVD----GVDSFSCECTRLWTGALCQV 469
C C SG+ G +C C +PCL G+C + G F C C G CQ
Sbjct: 1113 RCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQK 1172
Query: 470 PQQVCGESLSG 480
P E SG
Sbjct: 1173 PGAKGCEGRSG 1183
Score = 78.6 bits (192), Expect = 1e-13
Identities = 93/359 (25%), Positives = 119/359 (33%), Gaps = 96/359 (26%)
Query: 104 QNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK 163
QN ++ + Q + L + G + + C S PC N GTC F C CPP +
Sbjct: 940 QNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFV 999
Query: 164 GPLCSADVNEC-----------------------------------EIYSGTPLSCQNGG 188
G C DV+EC EI C +GG
Sbjct: 1000 GLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGG 1059
Query: 189 TCVNTMGS---YSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPKYS 244
TC T GS + CHCP GP C+ + C C H G+C L + G P
Sbjct: 1060 TCEATAGSPLGFICHCPKGFEGPTCSHRAPSC---GFHHCHHGGLC--LPSPKPGFPP-R 1113
Query: 245 CVCDAGWMFSPNSPAC-TLDRDECSFQPGPCSTLVQCFNTQGSFYCGAC--PTGWQGNGY 301
C C +G+ P C T + P PC Y G+C TG G G+
Sbjct: 1114 CACLSGY----GGPDCLTPPAPKGCGPPSPC------------LYNGSCSETTGLGGPGF 1157
Query: 302 ICEDINECEINNGG--CSVAPPVECVNTPGSSHCQA--CPPGYQGDGRVCTL-------- 349
C C ++ G C C G C A PG DG C+L
Sbjct: 1158 RC----SCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKG 1213
Query: 350 ---TDICSV--SNGGCHPDASCSSTLGSLPLC----TCLPGYT-------GNGYGPNGC 392
C + +G CHP L C C P Y NG+ GC
Sbjct: 1214 CPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGC 1272
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 201 bits (512), Expect = 8e-51
Identities = 131/355 (36%), Positives = 161/355 (45%), Gaps = 71/355 (20%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
+D C+SNPC GGTC++ D F CICP QW G C D NECE G P C N +C
Sbjct: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECE---GKP--CLNAFSC 438
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCDA 249
N +G Y C C P G C +DC G +C HG C+DL+ Y CVC
Sbjct: 439 KNLIGGYYCDCIPGWKGINCHINVNDCRG----QCQHGGTCKDLVNG------YQCVCPR 488
Query: 250 GWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINE 308
G+ C L+RDEC+ PC + C + F+C CP G+ G +CE D++
Sbjct: 489 GF----GGRHCELERDECA--SSPCHSGGLCEDLADGFHCH-CPQGFSGP--LCEVDVDL 539
Query: 309 CE---INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSN-----GGC 360
CE NG C N G +C ACP + G CSV G C
Sbjct: 540 CEPSPCRNGA-------RCYNLEGDYYC-ACPDDFGGKN--------CSVPREPCPGGAC 583
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYF-CK 419
C S G PG G S +C H G+C+ G F C
Sbjct: 584 RVIDGCGSDAG--------PGMPGTA--------ASGVCGPH----GRCVSQPGGNFSCI 623
Query: 420 CDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
CDSG+TG C ENI++CL PC NGGTC+D VD+F C C W G LC C
Sbjct: 624 CDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
Score = 194 bits (492), Expect = 2e-48
Identities = 122/381 (32%), Positives = 170/381 (44%), Gaps = 59/381 (15%)
Query: 122 RKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTP 181
R F G +++ C+S+PC +GG C +L D F C CP + GPLC DV+ CE P
Sbjct: 488 RGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE-----P 542
Query: 182 LSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEP 241
C+NG C N G Y C CP + G C+ + C GG+ R + G D G
Sbjct: 543 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTA 601
Query: 242 -----------------KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQ 284
+SC+CD+G+ C + D+C QP C C +
Sbjct: 602 ASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLGQP--CRNGGTCIDEV 655
Query: 285 GSFYCGACPTGWQGNGYICEDINECEINNGGCSVAP---PVECVNTPGSSHCQACPPGYQ 341
+F C CP+GW+G C+ N C P C + +C AC G++
Sbjct: 656 DAFRC-FCPSGWEGE--------LCDTNPNDCLPDPCHSRGRCYDLVNDFYC-ACDDGWK 705
Query: 342 GDGRVCTLT----DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSN 397
G + C D + SNGG D+ G C C PG+ G+ V ++
Sbjct: 706 G--KTCHSREFQCDAYTCSNGGTCYDS------GDTFRCACPPGWKGS----TCAVAKNS 753
Query: 398 ICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSC 456
CL +PC+NG C+ + + + C C GW G CT N N+C PC NGG CVDGV+ F C
Sbjct: 754 SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
Query: 457 ECTRLWTGALCQVPQQVCGES 477
EC + G C++ C S
Sbjct: 814 ECAPGFAGPDCRINIDECQSS 834
Score = 120 bits (301), Expect = 2e-26
Identities = 105/349 (30%), Positives = 138/349 (39%), Gaps = 48/349 (13%)
Query: 134 KVCSSNPCQNGGTCLNLHDSFF----CICPPQWKGPLCSADVNECEIYSGTPLSCQNGGT 189
K C C+ G C LH C C W+G C +EC Y G C +G +
Sbjct: 238 KECKEAVCKQG--CNLLHGGCTVPGECRCSYGWQGRFC----DECVPYPG----CVHG-S 286
Query: 190 CVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCD 248
CV + C+C G C + C GS C +G C + +Q Y C C
Sbjct: 287 CVEP---WQCNCETNWGGLLCDKDLNYC--GSHHPCTNGGTCINAEPDQ-----YRCTCP 336
Query: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINE 308
G+ + C C+ PC+ C F C CP+GW G DI+E
Sbjct: 337 DGY----SGRNCEKAEHACT--SNPCANGGSCHEVPSGFECH-CPSGWSGPTCAL-DIDE 388
Query: 309 CEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSS 368
C N A CV+ C CP Q G C L D C SC +
Sbjct: 389 CASN----PCAAGGTCVDQVDGFEC-ICPE--QWVGATCQL-DANECEGKPCLNAFSCKN 440
Query: 369 TLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVN 428
+G C C+PG+ G C N C G C D V+GY C C G+ G +
Sbjct: 441 LIGGY-YCDCIPGWKGIN-----CHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRH 494
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
C +EC S+PC +GG C D D F C C + ++G LC+V +C S
Sbjct: 495 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS 543
Score = 119 bits (299), Expect = 4e-26
Identities = 78/233 (33%), Positives = 101/233 (43%), Gaps = 30/233 (12%)
Query: 291 ACPTGWQGNGY---ICEDINECEINNGGCSVAPPV------------ECVNTPGSSHCQA 335
AC GW G +C+ C + +GGC+V ECV PG H
Sbjct: 230 ACMDGWMGKECKEAVCKQ--GCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSC 287
Query: 336 CPPGY-----QGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN 390
P G +C S+ C +C + CTC GY+G
Sbjct: 288 VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN---- 343
Query: 391 GCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVD 449
C + + C S+PC NG C + SG+ C C SGW+G C +I+EC SNPC GGTCVD
Sbjct: 344 -CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402
Query: 450 GVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFW 502
VD F C C W GA CQ+ C E +N +FS ++ GY D W
Sbjct: 403 QVDGFECICPEQWVGATCQLDANEC-EGKPCLN-AFSCKNLIGGYYCDCIPGW 453
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 198 bits (504), Expect = 7e-50
Identities = 125/350 (35%), Positives = 160/350 (45%), Gaps = 71/350 (20%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C+SNPC NGG+C + F C CP W GP C+ D++EC + P C GGTCV+ +
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDEC---ASNP--CAAGGTCVDQVD 405
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCDAGWMFS 254
+ C CP + G C +DC G +C HG C+DL+ Y CVC G+
Sbjct: 406 GFECICPEQWVGATCQLDVNDCRG----QCQHGGTCKDLVNG------YQCVCPRGF--- 452
Query: 255 PNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECE--- 310
C L+RDEC+ PC + C + F+C CP G+ G +CE D++ CE
Sbjct: 453 -GGRHCELERDECA--SSPCHSGGLCEDLADGFHCH-CPQGFSGP--LCEVDVDLCEPSP 506
Query: 311 INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSN-----GGCHPDAS 365
NG C N G +C ACP + G CSV G C
Sbjct: 507 CRNGA-------RCYNLEGDYYC-ACPDDFGGKN--------CSVPREPCPGGACRVIDG 550
Query: 366 CSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYF-CKCDSGW 424
C S G PG G S +C H G+C+ G F C CDSG+
Sbjct: 551 CGSDAG--------PGMPGTA--------ASGVCGPH----GRCVSQPGGNFSCICDSGF 590
Query: 425 TGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
TG C ENI++CL PC NGGTC+D VD+F C C W G LC C
Sbjct: 591 TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 640
Score = 196 bits (499), Expect = 3e-49
Identities = 122/362 (33%), Positives = 159/362 (43%), Gaps = 52/362 (14%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
+D C+SNPC GGTC++ D F CICP QW G C DVN+C CQ+GGTC
Sbjct: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR------GQCQHGGTC 437
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAG 250
+ + Y C CP G C + D+C G+CEDL + C C G
Sbjct: 438 KDLVNGYQCVCPRGFGGRHCELERDECASSPCHS--GGLCEDL------ADGFHCHCPQG 489
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECE 310
+ + P C +D D C +P PC +C+N +G +YC ACP + G C
Sbjct: 490 F----SGPLCEVDVDLC--EPSPCRNGARCYNLEGDYYC-ACPDDFGG--------KNCS 534
Query: 311 INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTL 370
+ C P C G PG G + ++G C P C S
Sbjct: 535 VPREPC---PGGACRVIDGCG--SDAGPGMPG-----------TAASGVCGPHGRCVSQP 578
Query: 371 GSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNC 429
G C C G+TG C + + CL PC N G CID V + C C SGW G C
Sbjct: 579 GGNFSCICDSGFTG-----TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
Query: 430 TENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRS 489
N N+CL +PC + G C D V+ F C C W G C + C ++ + NG Y S
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC-DAYTCSNGGTCYDS 692
Query: 490 PD 491
D
Sbjct: 693 GD 694
Score = 194 bits (492), Expect = 2e-48
Identities = 122/381 (32%), Positives = 170/381 (44%), Gaps = 59/381 (15%)
Query: 122 RKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTP 181
R F G +++ C+S+PC +GG C +L D F C CP + GPLC DV+ CE P
Sbjct: 450 RGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE-----P 504
Query: 182 LSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEP 241
C+NG C N G Y C CP + G C+ + C GG+ R + G D G
Sbjct: 505 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTA 563
Query: 242 -----------------KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQ 284
+SC+CD+G+ C + D+C QP C C +
Sbjct: 564 ASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLGQP--CRNGGTCIDEV 617
Query: 285 GSFYCGACPTGWQGNGYICEDINECEINNGGCSVAP---PVECVNTPGSSHCQACPPGYQ 341
+F C CP+GW+G C+ N C P C + +C AC G++
Sbjct: 618 DAFRC-FCPSGWEGE--------LCDTNPNDCLPDPCHSRGRCYDLVNDFYC-ACDDGWK 667
Query: 342 GDGRVCTLT----DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSN 397
G + C D + SNGG D+ G C C PG+ G+ V ++
Sbjct: 668 G--KTCHSREFQCDAYTCSNGGTCYDS------GDTFRCACPPGWKGS----TCAVAKNS 715
Query: 398 ICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSC 456
CL +PC+NG C+ + + + C C GW G CT N N+C PC NGG CVDGV+ F C
Sbjct: 716 SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 775
Query: 457 ECTRLWTGALCQVPQQVCGES 477
EC + G C++ C S
Sbjct: 776 ECAPGFAGPDCRINIDECQSS 796
Score = 118 bits (295), Expect = 1e-25
Identities = 70/205 (34%), Positives = 89/205 (43%), Gaps = 28/205 (13%)
Query: 291 ACPTGWQGNGY---ICEDINECEINNGGCSVAPPV------------ECVNTPGSSHCQA 335
AC GW G +C+ C + +GGC+V ECV PG H
Sbjct: 230 ACMDGWMGKECKEAVCKQ--GCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSC 287
Query: 336 CPPGY-----QGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN 390
P G +C S+ C +C + CTC GY+G
Sbjct: 288 VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN---- 343
Query: 391 GCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVD 449
C + + C S+PC NG C + SG+ C C SGW+G C +I+EC SNPC GGTCVD
Sbjct: 344 -CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402
Query: 450 GVDSFSCECTRLWTGALCQVPQQVC 474
VD F C C W GA CQ+ C
Sbjct: 403 QVDGFECICPEQWVGATCQLDVNDC 427
Score = 105 bits (261), Expect = 1e-21
Identities = 90/326 (27%), Positives = 118/326 (36%), Gaps = 57/326 (17%)
Query: 158 CPPQWKGPLCSADVNE--CEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYD 215
C W G C V + C + G C G C + G C D
Sbjct: 231 CMDGWMGKECKEAVCKQGCNLLHG---GCTVPGECRCSYGWQGRFC-------------D 274
Query: 216 DCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCS 275
+C CVHG C + + C C+ W C D + C PC+
Sbjct: 275 ECV--PYPGCVHGSCVE---------PWQCNCETNW----GGLLCDKDLNYCGSHH-PCT 318
Query: 276 TLVQCFNTQGSFYCGACPTGWQGNGYICEDINE-CEIN---NGGCSVAPPVECVNTPGSS 331
C N + Y CP G+ G CE C N NGG C P
Sbjct: 319 NGGTCINAEPDQYRCTCPDGYSGRN--CEKAEHACTSNPCANGG-------SCHEVPSGF 369
Query: 332 HCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNG 391
C CP G+ G C L DI ++ C +C + C C + G
Sbjct: 370 ECH-CPSGWSGP--TCAL-DIDECASNPCAAGGTCVDQVDGFE-CICPEQWVGAT----- 419
Query: 392 CVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGV 451
C N C G C D V+GY C C G+ G +C +EC S+PC +GG C D
Sbjct: 420 CQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 479
Query: 452 DSFSCECTRLWTGALCQVPQQVCGES 477
D F C C + ++G LC+V +C S
Sbjct: 480 DGFHCHCPQGFSGPLCEVDVDLCEPS 505
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 181 bits (458), Expect = 2e-44
Identities = 121/371 (32%), Positives = 163/371 (43%), Gaps = 63/371 (16%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDS---FFCICPPQWKGPLCSADVNECEIYSGTPLSCQNG 187
++ + C++ PC +G C+ F C C P ++GP C D++EC C +G
Sbjct: 66 MEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDEC-----ASRPCHHG 120
Query: 188 GTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCV 246
TC N Y CHCP G C + D+C A C+HG C D G + CV
Sbjct: 121 ATCRNLADRYECHCPLGYAGVTCEMEVDECAS---APCLHGGSCLD------GVGSFRCV 171
Query: 247 CDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDI 306
C G+ C LD DEC QP C+ C + F C TG++G
Sbjct: 172 CAPGY----GGTRCQLDLDECQSQP--CAHGGTCHDLVNGFRCDCAGTGYEGT------- 218
Query: 307 NECEINNGGCSVAP---PVECVNTPGSSHCQACPPGYQGDGRVCTLT-DICSVS---NGG 359
CE C+ AP C+ GS C C PGY G+ +C + D C+ S +GG
Sbjct: 219 -HCEREVLECASAPCEHNASCLEGLGSFRC-LCWPGYSGE--LCEVDEDECASSPCQHGG 274
Query: 360 CHPDASCSSTLGSLP---------------LCTCLPGYTGNGYGPNGCVQLSNICLSHPC 404
S + G + LC C PG+ G G V++ C S PC
Sbjct: 275 RCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCG----VEVDE-CASRPC 329
Query: 405 LNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWT 463
LNG C D +G+ C C G+ G C E+++ECLS+PCL+GGTC D V + C C W
Sbjct: 330 LNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWG 389
Query: 464 GALCQVPQQVC 474
G C V C
Sbjct: 390 GRDCSVQLTGC 400
Score = 95.9 bits (237), Expect = 6e-19
Identities = 77/274 (28%), Positives = 109/274 (39%), Gaps = 47/274 (17%)
Query: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQ-GSFYCG----------------- 290
AG + S AC D PC+ +C T+ G + CG
Sbjct: 31 AGTVPSEPPSACASD---------PCAPGTECQATESGGYTCGPMEPRGCATQPCHHGAL 81
Query: 291 ACPTGWQGNGYICEDIN-----ECEINNGGCSVAP---PVECVNTPGSSHCQACPPGYQG 342
P G G+ C + CE++ C+ P C N C CP GY G
Sbjct: 82 CVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECH-CPLGYAG 140
Query: 343 DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSH 402
V ++ ++ C SC +GS C C PGY G C + C S
Sbjct: 141 ---VTCEMEVDECASAPCLHGGSCLDGVGSFR-CVCAPGYGGTR-----CQLDLDECQSQ 191
Query: 403 PCLNG-QCIDTVSGYFCKC-DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTR 460
PC +G C D V+G+ C C +G+ G +C + EC S PC + +C++G+ SF C C
Sbjct: 192 PCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWP 251
Query: 461 LWTGALCQVPQQVCGESLSGINGSFSYRSPDVGY 494
++G LC+V + C S G RS Y
Sbjct: 252 GYSGELCEVDEDECASSPCQHGGRCLQRSDPALY 285
Score = 82.8 bits (203), Expect = 6e-15
Identities = 44/130 (33%), Positives = 61/130 (46%), Gaps = 15/130 (11%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
F+G V+ C+S PC NGG C +L + F C CP + GP C DV+EC
Sbjct: 312 FEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDEC-----LSDP 366
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGS---VARCVHGICEDLMREQAGE 240
C +GGTC +T+ Y C CP G C+ + C+G + A C+ ++G
Sbjct: 367 CLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIF-------ESGV 419
Query: 241 PKYSCVCDAG 250
Y C C G
Sbjct: 420 HSYVCHCPPG 429
Score = 73.6 bits (179), Expect = 3e-12
Identities = 39/117 (33%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTM 194
VC+ +PC + G C +L D+F C C P W+GP C A V+ C C G +
Sbjct: 1059 VCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCH-----SAPCARGRCHTHPD 1113
Query: 195 GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPKYSCVCDAG 250
G + C CPP GP+C E C+ G CE G P +C C G
Sbjct: 1114 GRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCE------GGSPAANCSCLEG 1164
Score = 62.8 bits (151), Expect = 6e-09
Identities = 49/160 (30%), Positives = 65/160 (40%), Gaps = 13/160 (8%)
Query: 328 PGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGY 387
PG+ A PG C +C+ S C D +C + C C PG+ G
Sbjct: 1035 PGAREHFASWPGTPAPILGCRGAPVCAPSP--CLHDGACRDLFDAFA-CACGPGWEGPR- 1090
Query: 388 GPNGCVQLSNICLSHPCLNGQCIDTVSGYF-CKCDSGWTGVNCTENI--NECLSN-PCLN 443
C + C S PC G+C G F C+C G+ G C + EC N CL+
Sbjct: 1091 ----CEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLD 1146
Query: 444 GGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGING 483
G C G + +C C G CQVP C E+ +NG
Sbjct: 1147 GSPCEGGSPAANCSCLEGLAGQRCQVPTLPC-EANPCLNG 1185
Score = 59.7 bits (143), Expect = 5e-08
Identities = 62/224 (27%), Positives = 73/224 (32%), Gaps = 58/224 (25%)
Query: 249 AGWMFSPNSPACTLD-RDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDIN 307
A W P +PA L R P PC C + +F C AC GW+G
Sbjct: 1042 ASW---PGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFAC-ACGPGWEGP-------- 1089
Query: 308 ECEINNGGCSVAPPVE--CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDAS 365
CE + C AP C P CPPG+ G C L P
Sbjct: 1090 RCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPR--CRLPV----------PSKE 1137
Query: 366 CSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWT 425
CS + TCL G PC G C C G
Sbjct: 1138 CSLNV------TCLDG--------------------SPCEGGSPAAN-----CSCLEGLA 1166
Query: 426 GVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQV 469
G C C +NPCLNGGTC C C ++G C+V
Sbjct: 1167 GQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 58.5 bits (140), Expect = 1e-07
Identities = 28/90 (31%), Positives = 42/90 (46%), Gaps = 3/90 (3%)
Query: 398 ICLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSC 456
+C PCL+ G C D + C C GW G C +++ C S PC G F C
Sbjct: 1059 VCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFEC 1118
Query: 457 ECTRLWTGALCQ--VPQQVCGESLSGINGS 484
C + G C+ VP + C +++ ++GS
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGS 1148
Score = 49.3 bits (116), Expect = 7e-05
Identities = 24/67 (35%), Positives = 34/67 (50%), Gaps = 3/67 (4%)
Query: 391 GCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVD 449
GCV ++C PC NG C+ T + + C C + +TG C + + C PCL TC +
Sbjct: 804 GCVS-EDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEE 861
Query: 450 GVDSFSC 456
D F C
Sbjct: 862 VPDGFVC 868
Score = 47.8 bits (112), Expect = 2e-04
Identities = 18/38 (47%), Positives = 24/38 (63%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCS 168
V + +CS +PC NGGTCL + F C CP + GP C+
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCA 843
Score = 38.9 bits (89), Expect = 0.094
Identities = 21/59 (35%), Positives = 29/59 (49%), Gaps = 4/59 (6%)
Query: 431 ENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALC--QVPQQVCGESLSGINGSFSY 487
E +C PC++GG+CVD F C+C R G C ++P G L G S S+
Sbjct: 604 ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFG--LGGAPSSASF 660
Score = 38.9 bits (89), Expect = 0.094
Identities = 15/34 (44%), Positives = 19/34 (55%)
Query: 180 TPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASK 213
+P C NGGTC+ T + C CP GP CA +
Sbjct: 812 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQ 845
Score = 37.7 bits (86), Expect = 0.21
Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 7/47 (14%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPL 182
C +NPC NGGTC CIC ++ G CE+ G PL
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQF-------CEVAKGLPL 1216
Score = 37.4 bits (85), Expect = 0.27
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 436 CLSNPCLNGGTCVDGVDSFSCECTRLWTGALC 467
C +PC NGGTC+ + F C C +TG C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842
Score = 36.6 bits (83), Expect = 0.46
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 133 KKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADV 171
++ C PC +GG+C++L F C C +GP C+ ++
Sbjct: 606 REQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 35.4 bits (80), Expect = 1.0
Identities = 29/111 (26%), Positives = 34/111 (30%), Gaps = 36/111 (32%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADV--NECEIY----------SGTPLS 183
C S PC G + F C CPP + GP C V EC + G+P +
Sbjct: 1098 CHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAA 1157
Query: 184 ------------------------CQNGGTCVNTMGSYSCHCPPETYGPQC 210
C NGGTC G C C G C
Sbjct: 1158 NCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 34.3 bits (77), Expect = 2.3
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 181 PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASK 213
PL C +GG+CV+ + C C GP CA +
Sbjct: 611 PLPCVHGGSCVDLWTHFRCDCARPHRGPTCADE 643
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 174 bits (440), Expect = 2e-42
Identities = 116/330 (35%), Positives = 154/330 (46%), Gaps = 33/330 (10%)
Query: 140 PCQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
PC G C N SF C+CP ++ G C DV+EC + +P C G C N G
Sbjct: 572 PCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQ-DVDEC---TQSPGLCGRGA-CKNLPG 625
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
S+ C CP G C D+C C G C++ AG + C C AG+
Sbjct: 626 SFRCVCPAGFRGSACEEDVDEC-AQEPPPCGPGRCDNT----AGS--FHCACPAGFRSRG 678
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINN 313
C D DEC+ P PC T +C NT+GSF C CP G+Q N G CED++ECE N+
Sbjct: 679 PGAPCQ-DVDECARSPPPC-TYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECE-NH 734
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C P ECVN+PGS C+ CP G+ CT D CS C P C++T GS
Sbjct: 735 LAC---PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSF 791
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL-NGQCIDTVSGYFCKCDSGW----TGVN 428
C+C PGY P C ++ C +G+C++T + C C G+ G +
Sbjct: 792 -RCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS 850
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSCEC 458
C + ++EC G C + SF C C
Sbjct: 851 CLD-VDECSEEDLCQSGICTNTDGSFECIC 879
Score = 121 bits (303), Expect = 1e-26
Identities = 103/306 (33%), Positives = 132/306 (43%), Gaps = 38/306 (12%)
Query: 132 DKKVCSSN--PCQNGGTCLNLHDSFFCICPPQWKGPL----CSADVNECEIYSGTPLSCQ 185
D CSS PC G C N SF C C P ++ P ADVNEC G C
Sbjct: 767 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC--LEGD--FCF 822
Query: 186 NGGTCVNTMGSYSCHCPP-ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
G C+NT GS++C C P GP+ AS D E C GIC + + +
Sbjct: 823 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT------DGSFE 876
Query: 245 CVCDAGWMFSPNSPACTLDRDECSFQ-PGPCSTLVQCFNTQGSFYC-GACPTGWQ-GNGY 301
C+C G P+ +C LD DEC + P C + +C N+ GS+ C C G+ G
Sbjct: 877 CICPPGHRAGPDLASC-LDVDECRERGPALCGS-QRCENSPGSYRCVRDCDPGYHAGPEG 934
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHC-QACPPGYQ-GDGRVCTLTDICSVSNGG 359
C+D++EC+ G + C NTPGS C AC PGYQ G C D C +
Sbjct: 935 TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRSF 991
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYG-----PNGCVQLSNICLSHPCLNGQCIDTVS 414
C A C + GS C C GY G G N C L +C + C N +
Sbjct: 992 CGAHAVCQNLPGSFQ-CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVE-----G 1045
Query: 415 GYFCKC 420
+ C C
Sbjct: 1046 SFLCVC 1051
Score = 106 bits (265), Expect = 4e-22
Identities = 79/230 (34%), Positives = 107/230 (46%), Gaps = 32/230 (13%)
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NG 300
Y+C CD+G+ SP C +D DEC P PC+ +C N+ GSF C C G++
Sbjct: 501 YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAP-GRCENSPGSFRC-VCGPGFRAGPRA 557
Query: 301 YICEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQG--DGRVCTLTDICSV 355
C D++EC V PP + C NTPGS C CP GYQ G C D C+
Sbjct: 558 AECLDVDECH------RVPPPCDLGRCENTPGSFLC-VCPAGYQAAPHGASCQDVDECTQ 610
Query: 356 SNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSH--PCLNGQCIDTV 413
S G C A C + GS C C G+ G + C + + C PC G+C +T
Sbjct: 611 SPGLCGRGA-CKNLPGSF-RCVCPAGFRG-----SACEEDVDECAQEPPPCGPGRCDNTA 663
Query: 414 SGYFCKCDSGW----TGVNCTENINECL-SNPCLNGGTCVDGVDSFSCEC 458
+ C C +G+ G C ++++EC S P G C + SF C C
Sbjct: 664 GSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYGRCENTEGSFQCVC 712
Score = 85.9 bits (211), Expect = 7e-16
Identities = 105/380 (27%), Positives = 143/380 (37%), Gaps = 67/380 (17%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK-GPLCSA--DVNECEIYSGTPLSCQNG 187
+D CS G C N SF CICPP + GP ++ DV+EC P C
Sbjct: 852 LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECR--ERGPALC-GS 908
Query: 188 GTCVNTMGSYSC--HCPPETY-GPQ-CASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C N+ GSY C C P + GP+ D+C+ C CE+ G +
Sbjct: 909 QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN----TPGSYRC 964
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NGY 301
+ CD G+ +P C D DEC C C N GSF C C G++G +G
Sbjct: 965 TPACDPGYQPTPGG-GCQ-DVDECR-NRSFCGAHAVCQNLPGSFQC-LCDQGYEGARDGR 1020
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQG----DGRVCTLTDICSVSN 357
C D+NECE G C A C N GS C CP + GR C + +
Sbjct: 1021 HCVDVNECETLQGVCGAA---LCENVEGSFLC-VCPNSPEEFDPMTGR-CVPPRTSAGTF 1075
Query: 358 GGCHPDASCSSTLGSLPLCTCLP--------GYTGNG--------YGPNGC-------VQ 394
G P A S L + P LP G G+G P+ C V
Sbjct: 1076 PGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVT 1135
Query: 395 LSNICLS------HPCLNGQCIDTVSGYF---CKCDSGWTG----VNCTENINEC--LSN 439
C + C QC T + + C G+ ++ +++EC +
Sbjct: 1136 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1195
Query: 440 PCLNGGTCVDGVDSFSCECT 459
G CV+ +SC C+
Sbjct: 1196 QVCKSGVCVNTAPGYSCYCS 1215
Score = 57.8 bits (138), Expect = 2e-07
Identities = 87/338 (25%), Positives = 124/338 (36%), Gaps = 90/338 (26%)
Query: 200 HCPPETYGPQCASKYDD-------CEGGSVARCVHG--ICEDLMREQAGEPKYSCVCDAG 250
+C E G +CAS C G +A VH +C + + C G
Sbjct: 221 YCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 280
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ---------GNGY 301
F + +C D DEC+ G C +C NT+G + C CP G+
Sbjct: 281 --FERVNGSCE-DVDECA-TGGRCQH-GECANTRGGYTC-VCPDGFLLDSSRSSCISQHV 334
Query: 302 ICEDINEC--EINNGGCS------VAPPVECVNTPGSSH---CQACPP-GYQGDGRVC-- 347
I E C + +GGCS + + C + G + CQ CPP G +G +C
Sbjct: 335 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 394
Query: 348 ------TLTDI-------------CSVSNGGCHPDASCSSTLGSLPL------------- 375
+ +D+ S+S P S S G LP
Sbjct: 395 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSA-GFLPTHRLEPRPEPRPDP 453
Query: 376 -------CTCLPGYTGNGYGPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW-- 424
+P +TG +G S +C +P C G+CI SGY C CDSG+
Sbjct: 454 RPGPELPLPSIPAWTGPEIPESG--PSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 511
Query: 425 --TGVNCTENINEC--LSNPCLNGGTCVDGVDSFSCEC 458
G C + ++EC + PC G C + SF C C
Sbjct: 512 SPQGTRCID-VDECRRVPPPCA-PGRCENSPGSFRCVC 547
Score = 56.2 bits (134), Expect = 6e-07
Identities = 79/302 (26%), Positives = 103/302 (34%), Gaps = 57/302 (18%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCS---ADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C C NL SF C+C ++G DVNECE G C C N GS+
Sbjct: 992 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV---C-GAALCENVEGSF 1047
Query: 198 SCHCP--PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE-PKYSCVCDAGWMFS 254
C CP PE + P RCV R AG P A +
Sbjct: 1048 LCVCPNSPEEFDPM------------TGRCVPP------RTSAGTFPGSQPQAPASPVLP 1089
Query: 255 PNSPACTLDRDECSFQPGPC-STLVQC-FNTQGSFYCG---ACPTGWQGNGYICEDINEC 309
P L R + + GP S +C F+T C A WQ C C
Sbjct: 1090 ARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE---CC-----C 1141
Query: 310 EINNGGCSVAPPVECVNTPGSSHCQACPPGY-----QGDGRVCTLTDICSVSNGGCHPDA 364
+ G S +C T + + CP G GD + D C +
Sbjct: 1142 TVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1201
Query: 365 SCSSTLGSLPLCTCLPGYTGNGYGPNG----CVQLSNICLSHP-CLNGQCIDTVSGYFCK 419
C +T P +C Y NGY + C+ P C G+C++TV Y C
Sbjct: 1202 VCVNTA---PGYSC---YCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1255
Query: 420 CD 421
C+
Sbjct: 1256 CE 1257
Score = 40.0 bits (92), Expect = 0.042
Identities = 49/188 (26%), Positives = 63/188 (33%), Gaps = 46/188 (24%)
Query: 163 KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSV 222
+GP+ S EC + P +C N N C E +G C + C G
Sbjct: 1106 QGPVGSGR-RECYFDTAAPDACDNI-LARNVTWQECCCTVGEGWGSGC--RIQQCPGTET 1161
Query: 223 AR----CVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECS-FQPGPCSTL 277
A C HG G++ + D DEC F+ C +
Sbjct: 1162 AEYQSLCPHG--------------------RGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1201
Query: 278 VQCFNTQGSFYCGACPTGWQGNGYI-------CEDINECEINNGGCSVAPPVECVNTPGS 330
V C NT + C + NGY C D +EC C CVNT GS
Sbjct: 1202 V-CVNTAPGYSC------YCSNGYYYHTQRLECIDNDECADEEPACEGG---RCVNTVGS 1251
Query: 331 SHCQACPP 338
HC PP
Sbjct: 1252 YHCTCEPP 1259
Score = 38.5 bits (88), Expect = 0.12
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 127 LQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLS 183
L++ VD+ + G C+N + C C + L D +EC + +
Sbjct: 1183 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDEC---ADEEPA 1239
Query: 184 CQNGGTCVNTMGSYSCHCPP 203
C+ GG CVNT+GSY C C P
Sbjct: 1240 CE-GGRCVNTVGSYHCTCEP 1258
Score = 38.1 bits (87), Expect = 0.16
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 5/66 (7%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C NG C+ + + F C C ++ + D+NEC+ C N C+NT GS+
Sbjct: 1476 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA-RCLNTDGSF 1533
Query: 198 SCHCPP 203
C C P
Sbjct: 1534 RCICRP 1539
Score = 38.1 bits (87), Expect = 0.16
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 9/63 (14%)
Query: 404 CLNGQCIDTVSGYFCKCDSGW----TGVNCTENINEC----LSNPCLNGGTCVDGVDSFS 455
C NG+C+ G+ C+C G+ T + C + INEC ++P C++ SF
Sbjct: 1476 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVNARCLNTDGSFR 1534
Query: 456 CEC 458
C C
Sbjct: 1535 CIC 1537
Score = 37.0 bits (84), Expect = 0.36
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 262 LDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINNGGCSVA 319
L+ +EC G T +C F C C G++ + C DINEC+ +
Sbjct: 1465 LEAEECGILDG--CTNGRCVRVPEGFTC-RCFDGYRLDMTRMACVDINECDEAEAASPLC 1521
Query: 320 PPVECVNTPGSSHCQACPPGY 340
C+NT GS C C PG+
Sbjct: 1522 VNARCLNTDGSFRC-ICRPGF 1541
Score = 33.9 bits (76), Expect = 3.0
Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 21/156 (13%)
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGP-NG-CVQLSNICLSHPCLNGQCIDTVSGY 416
G H CS LG+ + G G+ NG C + C +G+C +T GY
Sbjct: 253 GVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGY 312
Query: 417 FCKCDSGW----TGVNC-TENINECLSNPC---LNGGTC----VDGVDSFSCECTRL--- 461
C C G+ + +C ++++ PC L G C + + C C+R+
Sbjct: 313 TCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKA 372
Query: 462 WTGALCQVPQQVCGESLSGI---NGSFSYRSPDVGY 494
W G CQ+ E I + Y + D+ Y
Sbjct: 373 W-GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRY 407
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 174 bits (440), Expect = 2e-42
Identities = 116/330 (35%), Positives = 154/330 (46%), Gaps = 33/330 (10%)
Query: 140 PCQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
PC G C N SF C+CP ++ G C DV+EC + +P C G C N G
Sbjct: 602 PCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQ-DVDEC---TQSPGLCGRGA-CKNLPG 655
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
S+ C CP G C D+C C G C++ AG + C C AG+
Sbjct: 656 SFRCVCPAGFRGSACEEDVDEC-AQEPPPCGPGRCDNT----AGS--FHCACPAGFRSRG 708
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINN 313
C D DEC+ P PC T +C NT+GSF C CP G+Q N G CED++ECE N+
Sbjct: 709 PGAPCQ-DVDECARSPPPC-TYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECE-NH 764
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C P ECVN+PGS C+ CP G+ CT D CS C P C++T GS
Sbjct: 765 LAC---PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSF 821
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL-NGQCIDTVSGYFCKCDSGW----TGVN 428
C+C PGY P C ++ C +G+C++T + C C G+ G +
Sbjct: 822 -RCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS 880
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSCEC 458
C + ++EC G C + SF C C
Sbjct: 881 CLD-VDECSEEDLCQSGICTNTDGSFECIC 909
Score = 121 bits (303), Expect = 1e-26
Identities = 103/306 (33%), Positives = 132/306 (43%), Gaps = 38/306 (12%)
Query: 132 DKKVCSSN--PCQNGGTCLNLHDSFFCICPPQWKGPL----CSADVNECEIYSGTPLSCQ 185
D CSS PC G C N SF C C P ++ P ADVNEC G C
Sbjct: 797 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC--LEGD--FCF 852
Query: 186 NGGTCVNTMGSYSCHCPP-ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
G C+NT GS++C C P GP+ AS D E C GIC + + +
Sbjct: 853 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT------DGSFE 906
Query: 245 CVCDAGWMFSPNSPACTLDRDECSFQ-PGPCSTLVQCFNTQGSFYC-GACPTGWQ-GNGY 301
C+C G P+ +C LD DEC + P C + +C N+ GS+ C C G+ G
Sbjct: 907 CICPPGHRAGPDLASC-LDVDECRERGPALCGS-QRCENSPGSYRCVRDCDPGYHAGPEG 964
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHC-QACPPGYQ-GDGRVCTLTDICSVSNGG 359
C+D++EC+ G + C NTPGS C AC PGYQ G C D C +
Sbjct: 965 TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRSF 1021
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYG-----PNGCVQLSNICLSHPCLNGQCIDTVS 414
C A C + GS C C GY G G N C L +C + C N +
Sbjct: 1022 CGAHAVCQNLPGSFQ-CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVE-----G 1075
Query: 415 GYFCKC 420
+ C C
Sbjct: 1076 SFLCVC 1081
Score = 106 bits (265), Expect = 4e-22
Identities = 79/230 (34%), Positives = 107/230 (46%), Gaps = 32/230 (13%)
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NG 300
Y+C CD+G+ SP C +D DEC P PC+ +C N+ GSF C C G++
Sbjct: 531 YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAP-GRCENSPGSFRC-VCGPGFRAGPRA 587
Query: 301 YICEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQG--DGRVCTLTDICSV 355
C D++EC V PP + C NTPGS C CP GYQ G C D C+
Sbjct: 588 AECLDVDECH------RVPPPCDLGRCENTPGSFLC-VCPAGYQAAPHGASCQDVDECTQ 640
Query: 356 SNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSH--PCLNGQCIDTV 413
S G C A C + GS C C G+ G + C + + C PC G+C +T
Sbjct: 641 SPGLCGRGA-CKNLPGSF-RCVCPAGFRG-----SACEEDVDECAQEPPPCGPGRCDNTA 693
Query: 414 SGYFCKCDSGW----TGVNCTENINECL-SNPCLNGGTCVDGVDSFSCEC 458
+ C C +G+ G C ++++EC S P G C + SF C C
Sbjct: 694 GSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYGRCENTEGSFQCVC 742
Score = 85.9 bits (211), Expect = 7e-16
Identities = 105/380 (27%), Positives = 143/380 (37%), Gaps = 67/380 (17%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK-GPLCSA--DVNECEIYSGTPLSCQNG 187
+D CS G C N SF CICPP + GP ++ DV+EC P C
Sbjct: 882 LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECR--ERGPALC-GS 938
Query: 188 GTCVNTMGSYSC--HCPPETY-GPQ-CASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C N+ GSY C C P + GP+ D+C+ C CE+ G +
Sbjct: 939 QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN----TPGSYRC 994
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NGY 301
+ CD G+ +P C D DEC C C N GSF C C G++G +G
Sbjct: 995 TPACDPGYQPTPGG-GCQ-DVDECR-NRSFCGAHAVCQNLPGSFQC-LCDQGYEGARDGR 1050
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQG----DGRVCTLTDICSVSN 357
C D+NECE G C A C N GS C CP + GR C + +
Sbjct: 1051 HCVDVNECETLQGVCGAA---LCENVEGSFLC-VCPNSPEEFDPMTGR-CVPPRTSAGTF 1105
Query: 358 GGCHPDASCSSTLGSLPLCTCLP--------GYTGNG--------YGPNGC-------VQ 394
G P A S L + P LP G G+G P+ C V
Sbjct: 1106 PGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVT 1165
Query: 395 LSNICLS------HPCLNGQCIDTVSGYF---CKCDSGWTG----VNCTENINEC--LSN 439
C + C QC T + + C G+ ++ +++EC +
Sbjct: 1166 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1225
Query: 440 PCLNGGTCVDGVDSFSCECT 459
G CV+ +SC C+
Sbjct: 1226 QVCKSGVCVNTAPGYSCYCS 1245
Score = 57.8 bits (138), Expect = 2e-07
Identities = 87/338 (25%), Positives = 124/338 (36%), Gaps = 90/338 (26%)
Query: 200 HCPPETYGPQCASKYDD-------CEGGSVARCVHG--ICEDLMREQAGEPKYSCVCDAG 250
+C E G +CAS C G +A VH +C + + C G
Sbjct: 251 YCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 310
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ---------GNGY 301
F + +C D DEC+ G C +C NT+G + C CP G+
Sbjct: 311 --FERVNGSCE-DVDECA-TGGRCQH-GECANTRGGYTC-VCPDGFLLDSSRSSCISQHV 364
Query: 302 ICEDINEC--EINNGGCS------VAPPVECVNTPGSSH---CQACPP-GYQGDGRVC-- 347
I E C + +GGCS + + C + G + CQ CPP G +G +C
Sbjct: 365 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 424
Query: 348 ------TLTDI-------------CSVSNGGCHPDASCSSTLGSLPL------------- 375
+ +D+ S+S P S S G LP
Sbjct: 425 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSA-GFLPTHRLEPRPEPRPDP 483
Query: 376 -------CTCLPGYTGNGYGPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW-- 424
+P +TG +G S +C +P C G+CI SGY C CDSG+
Sbjct: 484 RPGPELPLPSIPAWTGPEIPESG--PSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 541
Query: 425 --TGVNCTENINEC--LSNPCLNGGTCVDGVDSFSCEC 458
G C + ++EC + PC G C + SF C C
Sbjct: 542 SPQGTRCID-VDECRRVPPPCA-PGRCENSPGSFRCVC 577
Score = 56.2 bits (134), Expect = 6e-07
Identities = 79/302 (26%), Positives = 103/302 (34%), Gaps = 57/302 (18%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCS---ADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C C NL SF C+C ++G DVNECE G C C N GS+
Sbjct: 1022 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV---C-GAALCENVEGSF 1077
Query: 198 SCHCP--PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE-PKYSCVCDAGWMFS 254
C CP PE + P RCV R AG P A +
Sbjct: 1078 LCVCPNSPEEFDPM------------TGRCVPP------RTSAGTFPGSQPQAPASPVLP 1119
Query: 255 PNSPACTLDRDECSFQPGPC-STLVQC-FNTQGSFYCG---ACPTGWQGNGYICEDINEC 309
P L R + + GP S +C F+T C A WQ C C
Sbjct: 1120 ARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE---CC-----C 1171
Query: 310 EINNGGCSVAPPVECVNTPGSSHCQACPPGY-----QGDGRVCTLTDICSVSNGGCHPDA 364
+ G S +C T + + CP G GD + D C +
Sbjct: 1172 TVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1231
Query: 365 SCSSTLGSLPLCTCLPGYTGNGYGPNG----CVQLSNICLSHP-CLNGQCIDTVSGYFCK 419
C +T P +C Y NGY + C+ P C G+C++TV Y C
Sbjct: 1232 VCVNTA---PGYSC---YCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1285
Query: 420 CD 421
C+
Sbjct: 1286 CE 1287
Score = 40.0 bits (92), Expect = 0.042
Identities = 49/188 (26%), Positives = 63/188 (33%), Gaps = 46/188 (24%)
Query: 163 KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSV 222
+GP+ S EC + P +C N N C E +G C + C G
Sbjct: 1136 QGPVGSGR-RECYFDTAAPDACDNI-LARNVTWQECCCTVGEGWGSGC--RIQQCPGTET 1191
Query: 223 AR----CVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECS-FQPGPCSTL 277
A C HG G++ + D DEC F+ C +
Sbjct: 1192 AEYQSLCPHG--------------------RGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1231
Query: 278 VQCFNTQGSFYCGACPTGWQGNGYI-------CEDINECEINNGGCSVAPPVECVNTPGS 330
V C NT + C + NGY C D +EC C CVNT GS
Sbjct: 1232 V-CVNTAPGYSC------YCSNGYYYHTQRLECIDNDECADEEPACEGG---RCVNTVGS 1281
Query: 331 SHCQACPP 338
HC PP
Sbjct: 1282 YHCTCEPP 1289
Score = 38.5 bits (88), Expect = 0.12
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 127 LQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLS 183
L++ VD+ + G C+N + C C + L D +EC + +
Sbjct: 1213 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDEC---ADEEPA 1269
Query: 184 CQNGGTCVNTMGSYSCHCPP 203
C+ GG CVNT+GSY C C P
Sbjct: 1270 CE-GGRCVNTVGSYHCTCEP 1288
Score = 38.1 bits (87), Expect = 0.16
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 5/66 (7%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C NG C+ + + F C C ++ + D+NEC+ C N C+NT GS+
Sbjct: 1506 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA-RCLNTDGSF 1563
Query: 198 SCHCPP 203
C C P
Sbjct: 1564 RCICRP 1569
Score = 38.1 bits (87), Expect = 0.16
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 9/63 (14%)
Query: 404 CLNGQCIDTVSGYFCKCDSGW----TGVNCTENINEC----LSNPCLNGGTCVDGVDSFS 455
C NG+C+ G+ C+C G+ T + C + INEC ++P C++ SF
Sbjct: 1506 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVNARCLNTDGSFR 1564
Query: 456 CEC 458
C C
Sbjct: 1565 CIC 1567
Score = 37.0 bits (84), Expect = 0.36
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 262 LDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINNGGCSVA 319
L+ +EC G T +C F C C G++ + C DINEC+ +
Sbjct: 1495 LEAEECGILDG--CTNGRCVRVPEGFTC-RCFDGYRLDMTRMACVDINECDEAEAASPLC 1551
Query: 320 PPVECVNTPGSSHCQACPPGY 340
C+NT GS C C PG+
Sbjct: 1552 VNARCLNTDGSFRC-ICRPGF 1571
Score = 33.9 bits (76), Expect = 3.0
Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 21/156 (13%)
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGP-NG-CVQLSNICLSHPCLNGQCIDTVSGY 416
G H CS LG+ + G G+ NG C + C +G+C +T GY
Sbjct: 283 GVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGY 342
Query: 417 FCKCDSGW----TGVNC-TENINECLSNPC---LNGGTC----VDGVDSFSCECTRL--- 461
C C G+ + +C ++++ PC L G C + + C C+R+
Sbjct: 343 TCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKA 402
Query: 462 WTGALCQVPQQVCGESLSGI---NGSFSYRSPDVGY 494
W G CQ+ E I + Y + D+ Y
Sbjct: 403 W-GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRY 437
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 174 bits (440), Expect = 2e-42
Identities = 116/330 (35%), Positives = 154/330 (46%), Gaps = 33/330 (10%)
Query: 140 PCQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
PC G C N SF C+CP ++ G C DV+EC + +P C G C N G
Sbjct: 639 PCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQ-DVDEC---TQSPGLCGRGA-CKNLPG 692
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
S+ C CP G C D+C C G C++ AG + C C AG+
Sbjct: 693 SFRCVCPAGFRGSACEEDVDEC-AQEPPPCGPGRCDNT----AGS--FHCACPAGFRSRG 745
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINN 313
C D DEC+ P PC T +C NT+GSF C CP G+Q N G CED++ECE N+
Sbjct: 746 PGAPCQ-DVDECARSPPPC-TYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECE-NH 801
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C P ECVN+PGS C+ CP G+ CT D CS C P C++T GS
Sbjct: 802 LAC---PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSF 858
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHPCL-NGQCIDTVSGYFCKCDSGW----TGVN 428
C+C PGY P C ++ C +G+C++T + C C G+ G +
Sbjct: 859 -RCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS 917
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSCEC 458
C + ++EC G C + SF C C
Sbjct: 918 CLD-VDECSEEDLCQSGICTNTDGSFECIC 946
Score = 121 bits (303), Expect = 1e-26
Identities = 103/306 (33%), Positives = 132/306 (43%), Gaps = 38/306 (12%)
Query: 132 DKKVCSSN--PCQNGGTCLNLHDSFFCICPPQWKGPL----CSADVNECEIYSGTPLSCQ 185
D CSS PC G C N SF C C P ++ P ADVNEC G C
Sbjct: 834 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC--LEGD--FCF 889
Query: 186 NGGTCVNTMGSYSCHCPP-ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
G C+NT GS++C C P GP+ AS D E C GIC + + +
Sbjct: 890 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT------DGSFE 943
Query: 245 CVCDAGWMFSPNSPACTLDRDECSFQ-PGPCSTLVQCFNTQGSFYC-GACPTGWQ-GNGY 301
C+C G P+ +C LD DEC + P C + +C N+ GS+ C C G+ G
Sbjct: 944 CICPPGHRAGPDLASC-LDVDECRERGPALCGS-QRCENSPGSYRCVRDCDPGYHAGPEG 1001
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHC-QACPPGYQ-GDGRVCTLTDICSVSNGG 359
C+D++EC+ G + C NTPGS C AC PGYQ G C D C +
Sbjct: 1002 TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRSF 1058
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYG-----PNGCVQLSNICLSHPCLNGQCIDTVS 414
C A C + GS C C GY G G N C L +C + C N +
Sbjct: 1059 CGAHAVCQNLPGSFQ-CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVE-----G 1112
Query: 415 GYFCKC 420
+ C C
Sbjct: 1113 SFLCVC 1118
Score = 106 bits (265), Expect = 4e-22
Identities = 79/230 (34%), Positives = 107/230 (46%), Gaps = 32/230 (13%)
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NG 300
Y+C CD+G+ SP C +D DEC P PC+ +C N+ GSF C C G++
Sbjct: 568 YTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAP-GRCENSPGSFRC-VCGPGFRAGPRA 624
Query: 301 YICEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQG--DGRVCTLTDICSV 355
C D++EC V PP + C NTPGS C CP GYQ G C D C+
Sbjct: 625 AECLDVDECH------RVPPPCDLGRCENTPGSFLC-VCPAGYQAAPHGASCQDVDECTQ 677
Query: 356 SNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSH--PCLNGQCIDTV 413
S G C A C + GS C C G+ G + C + + C PC G+C +T
Sbjct: 678 SPGLCGRGA-CKNLPGSF-RCVCPAGFRG-----SACEEDVDECAQEPPPCGPGRCDNTA 730
Query: 414 SGYFCKCDSGW----TGVNCTENINECL-SNPCLNGGTCVDGVDSFSCEC 458
+ C C +G+ G C ++++EC S P G C + SF C C
Sbjct: 731 GSFHCACPAGFRSRGPGAPC-QDVDECARSPPPCTYGRCENTEGSFQCVC 779
Score = 85.9 bits (211), Expect = 7e-16
Identities = 105/380 (27%), Positives = 143/380 (37%), Gaps = 67/380 (17%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK-GPLCSA--DVNECEIYSGTPLSCQNG 187
+D CS G C N SF CICPP + GP ++ DV+EC P C
Sbjct: 919 LDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECR--ERGPALC-GS 975
Query: 188 GTCVNTMGSYSC--HCPPETY-GPQ-CASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C N+ GSY C C P + GP+ D+C+ C CE+ G +
Sbjct: 976 QRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN----TPGSYRC 1031
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NGY 301
+ CD G+ +P C D DEC C C N GSF C C G++G +G
Sbjct: 1032 TPACDPGYQPTPGG-GCQ-DVDECR-NRSFCGAHAVCQNLPGSFQC-LCDQGYEGARDGR 1087
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQG----DGRVCTLTDICSVSN 357
C D+NECE G C A C N GS C CP + GR C + +
Sbjct: 1088 HCVDVNECETLQGVCGAA---LCENVEGSFLC-VCPNSPEEFDPMTGR-CVPPRTSAGTF 1142
Query: 358 GGCHPDASCSSTLGSLPLCTCLP--------GYTGNG--------YGPNGC-------VQ 394
G P A S L + P LP G G+G P+ C V
Sbjct: 1143 PGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVT 1202
Query: 395 LSNICLS------HPCLNGQCIDTVSGYF---CKCDSGWTG----VNCTENINEC--LSN 439
C + C QC T + + C G+ ++ +++EC +
Sbjct: 1203 WQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRD 1262
Query: 440 PCLNGGTCVDGVDSFSCECT 459
G CV+ +SC C+
Sbjct: 1263 QVCKSGVCVNTAPGYSCYCS 1282
Score = 57.8 bits (138), Expect = 2e-07
Identities = 87/338 (25%), Positives = 124/338 (36%), Gaps = 90/338 (26%)
Query: 200 HCPPETYGPQCASKYDD-------CEGGSVARCVHG--ICEDLMREQAGEPKYSCVCDAG 250
+C E G +CAS C G +A VH +C + + C G
Sbjct: 288 YCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTG 347
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ---------GNGY 301
F + +C D DEC+ G C +C NT+G + C CP G+
Sbjct: 348 --FERVNGSCE-DVDECA-TGGRCQH-GECANTRGGYTC-VCPDGFLLDSSRSSCISQHV 401
Query: 302 ICEDINEC--EINNGGCS------VAPPVECVNTPGSSH---CQACPP-GYQGDGRVC-- 347
I E C + +GGCS + + C + G + CQ CPP G +G +C
Sbjct: 402 ISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPA 461
Query: 348 ------TLTDI-------------CSVSNGGCHPDASCSSTLGSLPL------------- 375
+ +D+ S+S P S S G LP
Sbjct: 462 GPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSA-GFLPTHRLEPRPEPRPDP 520
Query: 376 -------CTCLPGYTGNGYGPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW-- 424
+P +TG +G S +C +P C G+CI SGY C CDSG+
Sbjct: 521 RPGPELPLPSIPAWTGPEIPESG--PSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRL 578
Query: 425 --TGVNCTENINEC--LSNPCLNGGTCVDGVDSFSCEC 458
G C + ++EC + PC G C + SF C C
Sbjct: 579 SPQGTRCID-VDECRRVPPPCA-PGRCENSPGSFRCVC 614
Score = 56.2 bits (134), Expect = 6e-07
Identities = 79/302 (26%), Positives = 103/302 (34%), Gaps = 57/302 (18%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCS---ADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C C NL SF C+C ++G DVNECE G C C N GS+
Sbjct: 1059 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGV---C-GAALCENVEGSF 1114
Query: 198 SCHCP--PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE-PKYSCVCDAGWMFS 254
C CP PE + P RCV R AG P A +
Sbjct: 1115 LCVCPNSPEEFDPM------------TGRCVPP------RTSAGTFPGSQPQAPASPVLP 1156
Query: 255 PNSPACTLDRDECSFQPGPC-STLVQC-FNTQGSFYCG---ACPTGWQGNGYICEDINEC 309
P L R + + GP S +C F+T C A WQ C C
Sbjct: 1157 ARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQE---CC-----C 1208
Query: 310 EINNGGCSVAPPVECVNTPGSSHCQACPPGY-----QGDGRVCTLTDICSVSNGGCHPDA 364
+ G S +C T + + CP G GD + D C +
Sbjct: 1209 TVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1268
Query: 365 SCSSTLGSLPLCTCLPGYTGNGYGPNG----CVQLSNICLSHP-CLNGQCIDTVSGYFCK 419
C +T P +C Y NGY + C+ P C G+C++TV Y C
Sbjct: 1269 VCVNTA---PGYSC---YCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1322
Query: 420 CD 421
C+
Sbjct: 1323 CE 1324
Score = 40.0 bits (92), Expect = 0.042
Identities = 49/188 (26%), Positives = 63/188 (33%), Gaps = 46/188 (24%)
Query: 163 KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSV 222
+GP+ S EC + P +C N N C E +G C + C G
Sbjct: 1173 QGPVGSGR-RECYFDTAAPDACDNI-LARNVTWQECCCTVGEGWGSGC--RIQQCPGTET 1228
Query: 223 AR----CVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECS-FQPGPCSTL 277
A C HG G++ + D DEC F+ C +
Sbjct: 1229 AEYQSLCPHG--------------------RGYLAPSGDLSLRRDVDECQLFRDQVCKSG 1268
Query: 278 VQCFNTQGSFYCGACPTGWQGNGYI-------CEDINECEINNGGCSVAPPVECVNTPGS 330
V C NT + C + NGY C D +EC C CVNT GS
Sbjct: 1269 V-CVNTAPGYSC------YCSNGYYYHTQRLECIDNDECADEEPACEGG---RCVNTVGS 1318
Query: 331 SHCQACPP 338
HC PP
Sbjct: 1319 YHCTCEPP 1326
Score = 38.5 bits (88), Expect = 0.12
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 127 LQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLS 183
L++ VD+ + G C+N + C C + L D +EC + +
Sbjct: 1250 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDEC---ADEEPA 1306
Query: 184 CQNGGTCVNTMGSYSCHCPP 203
C+ GG CVNT+GSY C C P
Sbjct: 1307 CE-GGRCVNTVGSYHCTCEP 1325
Score = 38.1 bits (87), Expect = 0.16
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 5/66 (7%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C NG C+ + + F C C ++ + D+NEC+ C N C+NT GS+
Sbjct: 1543 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA-RCLNTDGSF 1600
Query: 198 SCHCPP 203
C C P
Sbjct: 1601 RCICRP 1606
Score = 38.1 bits (87), Expect = 0.16
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 9/63 (14%)
Query: 404 CLNGQCIDTVSGYFCKCDSGW----TGVNCTENINEC----LSNPCLNGGTCVDGVDSFS 455
C NG+C+ G+ C+C G+ T + C + INEC ++P C++ SF
Sbjct: 1543 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVNARCLNTDGSFR 1601
Query: 456 CEC 458
C C
Sbjct: 1602 CIC 1604
Score = 37.0 bits (84), Expect = 0.36
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 262 LDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GYICEDINECEINNGGCSVA 319
L+ +EC G T +C F C C G++ + C DINEC+ +
Sbjct: 1532 LEAEECGILDG--CTNGRCVRVPEGFTC-RCFDGYRLDMTRMACVDINECDEAEAASPLC 1588
Query: 320 PPVECVNTPGSSHCQACPPGY 340
C+NT GS C C PG+
Sbjct: 1589 VNARCLNTDGSFRC-ICRPGF 1608
Score = 33.9 bits (76), Expect = 3.0
Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 21/156 (13%)
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGP-NG-CVQLSNICLSHPCLNGQCIDTVSGY 416
G H CS LG+ + G G+ NG C + C +G+C +T GY
Sbjct: 320 GVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGY 379
Query: 417 FCKCDSGW----TGVNC-TENINECLSNPC---LNGGTC----VDGVDSFSCECTRL--- 461
C C G+ + +C ++++ PC L G C + + C C+R+
Sbjct: 380 TCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKA 439
Query: 462 WTGALCQVPQQVCGESLSGI---NGSFSYRSPDVGY 494
W G CQ+ E I + Y + D+ Y
Sbjct: 440 W-GRGCQLCPPFGSEGFREICPAGPGYHYSASDLRY 474
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 172 bits (436), Expect = 5e-42
Identities = 121/411 (29%), Positives = 172/411 (41%), Gaps = 82/411 (19%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTM- 194
C NPC+N TC +L+ S+ C C W G CS ++NEC+ P C NGG C +
Sbjct: 775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECD---SDP--CMNGGLCHESTI 829
Query: 195 -GSYSCHCPPETYGPQCASKYDDC-----------------------------EGGS--- 221
G + C CPP G C +Y+ C EG +
Sbjct: 830 PGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEI 889
Query: 222 -VARCV------HGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPC 274
V C+ +G CED++ + C+C G+ S C ++ +ECS +P C
Sbjct: 890 DVKDCLFLSCQDYGDCEDMVNN------FRCICRPGFSGS----LCEIEINECSSEP--C 937
Query: 275 STLVQCFNTQGSFYCGACPTGWQGNGYICE-DINECEINNGGCSVAPPVECVNTPGSSHC 333
C + F+C P + +G CE D+N+C+I+ CV +C
Sbjct: 938 KNNGTCVDLTNRFFCNCEP---EYHGPFCELDVNKCKIS----PCLDEENCVYRTDGYNC 990
Query: 334 QACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCV 393
C PGY G L + S C D C + C C G+ G C
Sbjct: 991 -LCAPGYTGINCEINLDECLSEP---CLHDGVCIDGINHYT-CDCKSGFFGTH-----CE 1040
Query: 394 QLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDS 453
+N CLS+PCL+G+C + ++ Y C CD+ T C IN+C S PC+N G C
Sbjct: 1041 TNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG 1100
Query: 454 FSCECTRLWTGALCQVPQQVCGE----SLSGINGSFSYRSPDVGYVHDVNC 500
F+C C R +TGA C+ C E S+ +NG P G+ D C
Sbjct: 1101 FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGP--GHTFDCRC 1149
Score = 162 bits (410), Expect = 6e-39
Identities = 111/365 (30%), Positives = 157/365 (43%), Gaps = 57/365 (15%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
+D + C S C+NG T +L FF C P +KG C D++EC + C+NG TC
Sbjct: 642 IDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH-----PCKNGATC 696
Query: 191 VNTMGSY--------------SCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMR 235
++ G+Y SC C P G +C DDC + C H C+DL
Sbjct: 697 IDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDC---ILNACEHNSTCKDL-- 751
Query: 236 EQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTG 295
Y CVC + W C + +EC PC C + S+ C C +G
Sbjct: 752 ----HLSYQCVCLSDW----EGNFCEQESNECKM--NPCKNNSTCTDLYKSYRC-ECTSG 800
Query: 296 WQGNGYICEDINECE----INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVC-TLT 350
W G E+INEC+ +N G C + PG C CPP Y G+ C
Sbjct: 801 WTGQN-CSEEINECDSDPCMNGGLCHES------TIPGQFVC-LCPPLY--TGQFCHQRY 850
Query: 351 DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQC 409
++C + + C +++C + + + C C + G C CL C + G C
Sbjct: 851 NLCDLLHNPCRNNSTCLALVDANQHCICREEFEG-----KNCEIDVKDCLFLSCQDYGDC 905
Query: 410 IDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQV 469
D V+ + C C G++G C INEC S PC N GTCVD + F C C + G C++
Sbjct: 906 EDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCEL 965
Query: 470 PQQVC 474
C
Sbjct: 966 DVNKC 970
Score = 152 bits (383), Expect = 8e-36
Identities = 110/402 (27%), Positives = 170/402 (42%), Gaps = 79/402 (19%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLN--------------LHDSFFCICPPQWKGPLCSA 169
F+G Q +D C+S+PC+NG TC++ + D F C+C P + G C
Sbjct: 673 FKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQ 732
Query: 170 DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI 229
D+++C + +C++ TC + SY C C + G C + ++C+ +
Sbjct: 733 DIDDCILN-----ACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKN--NST 785
Query: 230 CEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYC 289
C DL + Y C C +GW C+ + +EC P L G F C
Sbjct: 786 CTDLYK------SYRCECTSGW----TGQNCSEEINECDSDPCMNGGLCHESTIPGQFVC 835
Query: 290 GACPTGWQG------------------NGYIC---EDINE------------CEINNGGC 316
CP + G N C D N+ CEI+ C
Sbjct: 836 -LCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDC 894
Query: 317 ---SVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
S +C + + C C PG+ G +C + +I S+ C + +C L +
Sbjct: 895 LFLSCQDYGDCEDMVNNFRC-ICRPGFSGS--LCEI-EINECSSEPCKNNGTCVD-LTNR 949
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYFCKCDSGWTGVNCTEN 432
C C P Y +GP C N C PCL+ + C+ GY C C G+TG+NC N
Sbjct: 950 FFCNCEPEY----HGP-FCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEIN 1004
Query: 433 INECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
++ECLS PCL+ G C+DG++ ++C+C + G C+ C
Sbjct: 1005 LDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDC 1046
Score = 145 bits (367), Expect = 5e-34
Identities = 111/357 (31%), Positives = 168/357 (47%), Gaps = 51/357 (14%)
Query: 123 KFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPL 182
+F+G +D K C CQ+ G C ++ ++F CIC P + G LC ++NEC S P
Sbjct: 881 EFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINEC---SSEP- 936
Query: 183 SCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
C+N GTCV+ + C+C PE +GP C + C+ ++ C+ E+ + G
Sbjct: 937 -CKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCK---ISPCLDE--ENCVYRTDG--- 987
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
Y+C+C G+ C ++ DEC +P C C + + C C +G+ G
Sbjct: 988 YNCLCAPGY----TGINCEINLDECLSEP--CLHDGVCIDGINHYTCD-CKSGFFGTH-- 1038
Query: 303 CE-DINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNG 358
CE + N+C N +G C+ E +N S C A Q ++ T I ++ G
Sbjct: 1039 CETNANDCLSNPCLHGRCT-----ELINEYPCS-CDADGTSTQCKIKINDCTSIPCMNEG 1092
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICL-----SHPCLNGQ-CIDT 412
C A + C C GYTG Y C + + C S CLNG C+D
Sbjct: 1093 FCQKSAHGFT-------CICPRGYTG-AY----CEKSIDNCAEPELNSVICLNGGICVDG 1140
Query: 413 VSGYF-CKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
F C+C G++G C NINEC S+PCL+G C D ++ + C+C W+G C+
Sbjct: 1141 PGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Score = 133 bits (334), Expect = 4e-30
Identities = 99/362 (27%), Positives = 153/362 (42%), Gaps = 81/362 (22%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEI------- 176
F G ++ CSS PC+N GTC++L + FFC C P++ GP C DVN+C+I
Sbjct: 920 FSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEE 979
Query: 177 ----------------YSGTPLS----------CQNGGTCVNTMGSYSCHCPPETYGPQC 210
Y+G C + G C++ + Y+C C +G C
Sbjct: 980 NCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHC 1039
Query: 211 ASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQ 270
+ +DC C+HG C +L+ E Y C CDA S C + ++C+
Sbjct: 1040 ETNANDCLSNP---CLHGRCTELINE------YPCSCDA----DGTSTQCKIKINDCT-- 1084
Query: 271 PGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINEC---EIN-----NGGCSVAPPV 322
PC C + F C CP G+ G Y + I+ C E+N NGG
Sbjct: 1085 SIPCMNEGFCQKSAHGFTC-ICPRGYTG-AYCEKSIDNCAEPELNSVICLNGGI------ 1136
Query: 323 ECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGY 382
CV+ PG + C PG+ G+ C + +I S+ C A C + +C C PG+
Sbjct: 1137 -CVDGPGHTFDCRCLPGF--SGQFCEI-NINECSSSPCLHGADCEDHINGY-VCKCQPGW 1191
Query: 383 TGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW----TGVNCTENINE--C 436
+G+ + C+ + C++ C++ G C C G+ G+ C + I C
Sbjct: 1192 SGHH------CENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITC 1245
Query: 437 LS 438
L+
Sbjct: 1246 LT 1247
Score = 120 bits (301), Expect = 2e-26
Identities = 99/358 (27%), Positives = 139/358 (38%), Gaps = 78/358 (21%)
Query: 127 LQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQN 186
L+ T D + N CQ+ C + + C C + G LC +V+ C +S
Sbjct: 564 LENTTDDQ---ENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYC--LGNHSISVH- 617
Query: 187 GGTCVNTMGSYSCHCPP-ETYGPQ-CASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
G C+ S++C+C + Y C +DC+ S C +G +R
Sbjct: 618 -GLCLAL--SHNCNCSGLQRYERNICEIDTEDCKSAS---CKNGTTSTHLR--------- 662
Query: 245 CVCDAGWMFSPNSPA-----CTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN 299
G+ F P C +D DEC+ PC C + G+++C P +
Sbjct: 663 -----GYFFRKCVPGFKGTQCEIDIDECASH--PCKNGATCIDQPGNYFCQCVPPFKVVD 715
Query: 300 GYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
G+ C C PGY G + DI
Sbjct: 716 GFSC-------------------------------LCNPGYVG---IRCEQDIDDCILNA 741
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYFC 418
C +++C S C CL + GN C Q SN C +PC N C D Y C
Sbjct: 742 CEHNSTCKDLHLSYQ-CVCLSDWEGN-----FCEQESNECKMNPCKNNSTCTDLYKSYRC 795
Query: 419 KCDSGWTGVNCTENINECLSNPCLNGGTCVDGV--DSFSCECTRLWTGALCQVPQQVC 474
+C SGWTG NC+E INEC S+PC+NGG C + F C C L+TG C +C
Sbjct: 796 ECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLC 853
Score = 117 bits (293), Expect = 2e-25
Identities = 95/355 (26%), Positives = 135/355 (38%), Gaps = 68/355 (19%)
Query: 141 CQNGGTCLNLHDS--FFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYS 198
C NG +CL+ DS + +C +W G + + + + CQ+ C + +
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQ-----ENECQHEAVCKDEINRPR 589
Query: 199 CHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSP 258
C C G C D C G + VHG+C L ++C C + N
Sbjct: 590 CSCSLSYIGRLCVVNVDYCLGNH-SISVHGLCLAL--------SHNCNCSGLQRYERN-- 638
Query: 259 ACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSV 318
C +D ++C + C + +G F+ C G++G +CEI+ C+
Sbjct: 639 ICEIDTEDC--KSASCKNGTTSTHLRGYFF-RKCVPGFKGT--------QCEIDIDECAS 687
Query: 319 AP---PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPL 375
P C++ PG+ CQ PP DG C
Sbjct: 688 HPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCL--------------------------- 720
Query: 376 CTCLPGYTGNGYGPNGCVQLSNICLSHPCL-NGQCIDTVSGYFCKCDSGWTGVNCTENIN 434
C PGY G C Q + C+ + C N C D Y C C S W G C + N
Sbjct: 721 --CNPGYVGIR-----CEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESN 773
Query: 435 ECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRS 489
EC NPC N TC D S+ CECT WTG C C +S +NG + S
Sbjct: 774 ECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINEC-DSDPCMNGGLCHES 827
Score = 76.6 bits (187), Expect = 4e-13
Identities = 113/489 (23%), Positives = 155/489 (31%), Gaps = 167/489 (34%)
Query: 114 NSKLVDLERKFQGLQQTVDKKVC------------------------------------- 136
NS + + + +F G V K C
Sbjct: 276 NSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
Query: 137 -SSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
S PCQNG C+ + + CIC P + LC + CE + PL +N TC
Sbjct: 336 FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF---PL--RNNATCKKCEK 390
Query: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
Y C C C D C+ S+ C++ E+ G KY C+
Sbjct: 391 DYPCSCISGFTEKNCEKAIDHCKLLSI-NCLN---EEWCFNIIGRFKYVCI--------- 437
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNT-QGSFYCGACPTG-------------WQ---- 297
P CT PC L + Q YCG G WQ
Sbjct: 438 --PGCT---------KNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFA 486
Query: 298 -GNGYICED------------------INECEINNGGC---------SVAPPVECVNTPG 329
G C+ +N+ E NN C A C++
Sbjct: 487 GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEED 546
Query: 330 SSHCQ-ACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTG---- 384
S + C + G+ + TD C +A C + + P C+C Y G
Sbjct: 547 SQEYRYLCFLRWAGNMYLENTTD---DQENECQHEAVCKDEI-NRPRCSCSLSYIGRLCV 602
Query: 385 ---------NGYGPNG-CVQLS-------------NIC-------LSHPCLNGQCIDTVS 414
+ +G C+ LS NIC S C NG +
Sbjct: 603 VNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLR 662
Query: 415 GYFC-KCDSGWTGVNCTENINECLSNPCLNGGTCVDG--------------VDSFSCECT 459
GYF KC G+ G C +I+EC S+PC NG TC+D VD FSC C
Sbjct: 663 GYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCN 722
Query: 460 RLWTGALCQ 468
+ G C+
Sbjct: 723 PGYVGIRCE 731
Score = 72.0 bits (175), Expect = 1e-11
Identities = 82/346 (23%), Positives = 116/346 (33%), Gaps = 88/346 (25%)
Query: 127 LQQTVDKKVC----SSNPCQNGGTCLN--LHDSFFCICPPQWKGPLCSADVNECEIYSGT 180
L TV ++ C SS C G CL+ ++ C C P + G C E + S
Sbjct: 165 LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ----ELDACSFK 220
Query: 181 PLSCQNGGTCVNTMGS-----YSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMR 235
P C+N G+C+N + Y C C P G C+ C+ C HG C ++
Sbjct: 221 P--CKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV---CFHGNCSNITS 275
Query: 236 EQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTG 295
+ C CD + + P C + PC +L+ + G CP
Sbjct: 276 NS-----FICECDEQF----SGPFCEVSAK-------PCVSLL-------FWKRGICPNS 312
Query: 296 WQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSV 355
S++ CP G TD+
Sbjct: 313 ---------------------------------SSAYTYECPKGSSSQNGE---TDVSEF 336
Query: 356 SNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVS 414
S C C + +C C P +T C + C S P N C
Sbjct: 337 SLVPCQNGTDCIKISNDV-MCICSPIFTDLL-----CKSIQTSCESFPLRNNATCKKCEK 390
Query: 415 GYFCKCDSGWTGVNCTENINEC--LSNPCLNGGTCVDGVDSFSCEC 458
Y C C SG+T NC + I+ C LS CLN C + + F C
Sbjct: 391 DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
Score = 72.0 bits (175), Expect = 1e-11
Identities = 87/385 (22%), Positives = 125/385 (32%), Gaps = 97/385 (25%)
Query: 136 CSSNPCQNGGTCLNLHD-----SFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
CS PC+N G+C+N + ++ C+C P + G CS + +C+ P C +G
Sbjct: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-----PHVCFHGNCS 271
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAG 250
T S+ C C + GP C C S+ GIC + Y+ C G
Sbjct: 272 NITSNSFICECDEQFSGPFCEVSAKPCV--SLLFWKRGICPN------SSSAYTYECPKG 323
Query: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDI-NEC 309
S + + D F PC C C P +C+ I C
Sbjct: 324 ------SSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI---FTDLLCKSIQTSC 374
Query: 310 EI----NNGGCSVAP---PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHP 362
E NN C P C++ +C+ D C + + C
Sbjct: 375 ESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA-------------IDHCKLLSINCLN 421
Query: 363 DASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICL--SHPCLNG------------- 407
+ C + +G C+PG T N C L N+ L H C G
Sbjct: 422 EEWCFNIIGRFKY-VCIPGCT-----KNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPA 475
Query: 408 ----------------QCIDTVSGYF---CKCDSGWTGVNCTENINECLSNP-------C 441
+C + YF C T VN E+ N P C
Sbjct: 476 QFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEIC 535
Query: 442 LNGGTCVDGVDS--FSCECTRLWTG 464
NG +C+ DS + C W G
Sbjct: 536 ANGCSCLSEEDSQEYRYLCFLRWAG 560
Score = 69.7 bits (169), Expect = 5e-11
Identities = 29/75 (38%), Positives = 37/75 (49%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
CS C NGGTC+ S +C C WKG C+ V+ C+ P C G TC++
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 196 SYSCHCPPETYGPQC 210
Y+C CP T G C
Sbjct: 2674 GYTCFCPLGTTGIYC 2688
Score = 60.5 bits (145), Expect = 3e-08
Identities = 40/128 (31%), Positives = 57/128 (44%), Gaps = 13/128 (10%)
Query: 354 SVSNGGCHPDASCSSTLGSLPL-CTCLPGYTGNGYGPNGCVQLSNICLSHPCLN-GQCID 411
S+S+ C C S S C C P ++G C +L + C PC N G CI+
Sbjct: 177 SLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKY-----CQEL-DACSFKPCKNNGSCIN 230
Query: 412 T-----VSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGAL 466
Y C C +TG NC+E I +C + C +G +SF CEC ++G
Sbjct: 231 KRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPF 290
Query: 467 CQVPQQVC 474
C+V + C
Sbjct: 291 CEVSAKPC 298
Score = 55.8 bits (133), Expect = 7e-07
Identities = 53/228 (23%), Positives = 81/228 (35%), Gaps = 57/228 (25%)
Query: 292 CPTGWQGNGYICEDINECEINNGGCSVAPPV--ECVNTPGSSHCQACPPGYQGDGRVCTL 349
CP G + N + + + +++ CS E + S HCQ PP G+ C
Sbjct: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQ--PPF---SGKYCQE 213
Query: 350 TDICSVSNGGCHPDASCSSTLGSLPL----CTCLPGYTGNGYGPNGCVQLSNICLSHPCL 405
D CS C + SC + + C C P +TG C ++ C H C
Sbjct: 214 LDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFTGKN-----CSEIIGQCQPHVCF 266
Query: 406 NGQCIDTVSGYF-CKCDSGWTGVNCTENINECLSN------------------------- 439
+G C + S F C+CD ++G C + C+S
Sbjct: 267 HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSS 326
Query: 440 -------------PCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
PC NG C+ + C C+ ++T LC+ Q C
Sbjct: 327 QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSC 374
Score = 53.5 bits (127), Expect = 4e-06
Identities = 29/76 (38%), Positives = 39/76 (51%), Gaps = 8/76 (10%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C+ + C+N GTC++ +++ FC CP + G LC CE P C NG TCV G
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCE---NNP--CGNGATCVPKSG 2391
Query: 196 S-YSCHCPPETYGPQC 210
+ C CP GP C
Sbjct: 2392 TDIVCLCPYGRSGPLC 2407
Score = 52.4 bits (124), Expect = 8e-06
Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
Query: 399 CLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCV-DGVDSFSC 456
C + C NG +C + + C+C W G C ++++ CL+N CL+ C+ D S+SC
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 457 ECTRLWTGALCQ 468
CT W G C+
Sbjct: 2938 LCTLGWVGRYCE 2949
Score = 52.0 bits (123), Expect = 1e-05
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 11/96 (11%)
Query: 384 GNGYGPNGCVQLSNICLSHPCL------NGQCIDTVSGYFCKCDSGWTGVNCTENINEC- 436
GN G + C + PC G CI++ + +C C +GW G CTE ++ C
Sbjct: 2594 GNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCD 2653
Query: 437 ----LSNPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
+ C G TC+ ++C C TG C+
Sbjct: 2654 PEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 48.5 bits (114), Expect = 1e-04
Identities = 75/289 (25%), Positives = 98/289 (33%), Gaps = 69/289 (23%)
Query: 184 CQNGGTCVNTMGS--YSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGE 240
C G C++ S YSCHC P G C + D C S C + G C + RE E
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDAC---SFKPCKNNGSCIN-KRENWDE 237
Query: 241 PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG 300
Y CVC P T CS G C V CF+ G C + N
Sbjct: 238 QAYECVCH---------PPFT--GKNCSEIIGQCQPHV-CFH-------GNC-SNITSNS 277
Query: 301 YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC 360
+ICE C+ G P + + C + G C
Sbjct: 278 FICE----CDEQFSG----------------------PFCEVSAKPCV--SLLFWKRGIC 309
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCK 419
P++S + T C G + NG +S L PC NG CI + C
Sbjct: 310 -PNSSSAYTY------ECPKGSSSQ----NGETDVSEFSLV-PCQNGTDCIKISNDVMCI 357
Query: 420 CDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
C +T + C C S P N TC + C C +T C+
Sbjct: 358 CSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
Score = 47.8 bits (112), Expect = 2e-04
Identities = 33/94 (35%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 399 CLSHPCLN-GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCV--DGVDSFS 455
C H C N G CI FC+C ++G C C +NPC NG TCV G D
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVPKSGTD-IV 2395
Query: 456 CECTRLWTGALCQVPQQVCGESLSGINGSFSYRS 489
C C +G LC + SG + +F Y S
Sbjct: 2396 CLCPYGRSGPLCTDAINITQPRFSGTD-AFGYTS 2428
Score = 45.8 bits (107), Expect = 8e-04
Identities = 27/83 (32%), Positives = 33/83 (39%), Gaps = 7/83 (8%)
Query: 132 DKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCV 191
D C N C+NGG C +F C C P W G C+ V S C + C+
Sbjct: 2875 DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV------SCLNNLCLHQSLCI 2928
Query: 192 NTMG-SYSCHCPPETYGPQCASK 213
SYSC C G C +K
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYCENK 2951
Score = 42.0 bits (97), Expect = 0.011
Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 23/107 (21%)
Query: 367 SSTLGSLPLCTCLPGYTGNGYGPNGCV---QLSN--ICLSHPCLNGQCIDTVSGYFCKCD 421
S LG +P + G YG GC+ Q++N + +G+ I+ C
Sbjct: 2283 SMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIEN-------CH 2335
Query: 422 SGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
W C + C N GTC+ ++ CEC RL++G LCQ
Sbjct: 2336 VPW-----------CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ 2371
Score = 42.0 bits (97), Expect = 0.011
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 5/52 (9%)
Query: 428 NCTENINECLSNPCL-----NGGTCVDGVDSFSCECTRLWTGALCQVPQQVC 474
N ++ +C ++PC NGGTC++ S C CT W G+ C C
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTC 2652
Score = 40.8 bits (94), Expect = 0.025
Identities = 38/146 (26%), Positives = 62/146 (42%), Gaps = 27/146 (18%)
Query: 421 DSGWTGVNCTENI-NECLSNPCLNGGTC-----VDGVDSFSCECTRLWTGALCQVPQQVC 474
D+ WT V+ + + C + C NGGTC G+ SF C+C +TG C ++
Sbjct: 2087 DTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC---EKDA 2143
Query: 475 GESLSGINGSFSYRSPDVGYV------HDVNCFWVIKTEM--GKVLRITFTFFRLESMDN 526
G NG+ P + +V V + IKT G +L + +N
Sbjct: 2144 GLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTIL--------YSNGNN 2195
Query: 527 CPHEFLQVYDGDSSSAFQLGRFCGSS 552
C +FL ++ + + + G CG+S
Sbjct: 2196 CGKQFLHLFLVEGRPSVKYG--CGNS 2219
Score = 40.0 bits (92), Expect = 0.042
Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 16/88 (18%)
Query: 169 ADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG 228
++V +C+ + +C+NGG C ++SC C P+ G C C++
Sbjct: 2869 SNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS---------CLNN 2919
Query: 229 ICEDLMREQAGEP----KYSCVCDAGWM 252
+C + + P YSC+C GW+
Sbjct: 2920 LC---LHQSLCIPDQSFSYSCLCTLGWV 2944
Score = 39.7 bits (91), Expect = 0.055
Identities = 19/47 (40%), Positives = 27/47 (57%), Gaps = 2/47 (4%)
Query: 136 CSSNPCQNGGTCLNLHDS-FFCICPPQWKGPLCSADVNECE-IYSGT 180
C +NPC NG TC+ + C+CP GPLC+ +N + +SGT
Sbjct: 2375 CENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGT 2421
Score = 37.7 bits (86), Expect = 0.21
Identities = 21/68 (30%), Positives = 29/68 (42%), Gaps = 10/68 (14%)
Query: 436 CLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRS---PDV 492
C N C NGG C +FSC C W G C +S+S +N ++S PD
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAG-------NTCNQSVSCLNNLCLHQSLCIPDQ 2931
Query: 493 GYVHDVNC 500
+ + C
Sbjct: 2932 SFSYSCLC 2939
Score = 36.6 bits (83), Expect = 0.46
Identities = 49/171 (28%), Positives = 62/171 (36%), Gaps = 47/171 (27%)
Query: 275 STLVQCFNTQGSFYCGAC--------------PTGWQGNGYICEDINECEINNGGCSVAP 320
ST + +T FY G P G+QG C I + INN +
Sbjct: 2809 STKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQG----C--IRQVIINNQELQLTE 2862
Query: 321 PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLP 380
G S+ C DG C + NGG C+ G+ C CLP
Sbjct: 2863 ----FGAKGGSNVGDC------DGTACGYN---TCRNGG-----ECTVN-GTTFSCRCLP 2903
Query: 381 GYTGNGYGPNGCVQLSNICLSHPCLN-GQCI-DTVSGYFCKCDSGWTGVNC 429
+ G N C Q S CL++ CL+ CI D Y C C GW G C
Sbjct: 2904 DWAG-----NTCNQ-SVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 36.2 bits (82), Expect = 0.61
Identities = 29/110 (26%), Positives = 43/110 (39%), Gaps = 14/110 (12%)
Query: 337 PPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLS 396
P G+ GR S C +C + G+ C C G+ G+ C +
Sbjct: 2596 PEGHPNAGRSVGQCHASPCSLMKCGNGGTCIES-GTSVYCNCTTGWKGSF-----CTETV 2649
Query: 397 NIC-----LSHPCLNGQ-CIDTVSGYFCKCDSGWTGVNCTENINECLSNP 440
+ C H C G CI GY C C G TG+ C + ++ +S+P
Sbjct: 2650 STCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS--ISDP 2697
Score = 35.4 bits (80), Expect = 1.0
Identities = 15/54 (27%), Positives = 22/54 (40%)
Query: 165 PLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCE 218
P V +C + + C NGGTC+ + S C+C G C C+
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCD 2653
Score = 33.1 bits (74), Expect = 5.1
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 5/41 (12%)
Query: 135 VCSSNPCQNGGTCLNLH-----DSFFCICPPQWKGPLCSAD 170
VC + C NGGTC + SF C CP + G C D
Sbjct: 2102 VCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 168 bits (426), Expect = 8e-41
Identities = 117/383 (30%), Positives = 159/383 (41%), Gaps = 87/383 (22%)
Query: 133 KKVCSSNPCQNGGTCLNL--HDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
K C SNPCQ TC+N SF C CPP + G +C + C SCQ+GG C
Sbjct: 71 KDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCG-----KNSCQHGGIC 125
Query: 191 VNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCDA 249
C CP G C +D+C C +G +C+D G YSC C
Sbjct: 126 HQDPIYPVCICPAGYAGRFCEIDHDECASSP---CQNGAVCQD------GIDGYSCFCVP 176
Query: 250 GWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG----------- 298
G+ C L+ DEC+ P C C N G + C CP + G
Sbjct: 177 GYQ----GRHCDLEVDECASDP--CKNEATCLNEIGRYTC-ICPHNYSGVNCELEIDECW 229
Query: 299 -----NGYICEDI--------------NECEINNGGCSVAPPVE---CVNTPGSSHCQAC 336
NG C+D + CE+N C+ P + CV+ C
Sbjct: 230 SQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCT 289
Query: 337 PPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLS 396
G+ G TL +C + CH +A+C ++ + C C PGYTG C
Sbjct: 290 GSGFTGT-HCETLMPLCW--SKPCHNNATCEDSVDNYT-CHCWPGYTGAQ-----CEIDL 340
Query: 397 NICLSHPCL-NGQCIDT--------------------VSGYFCKCDSGWTGVNCTENINE 435
N C S+PC NG+C++ SGY C C G+TG++C E++NE
Sbjct: 341 NECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNE 400
Query: 436 CLSNPCLNGGTCVDGVDSFSCEC 458
C SNPC NGGTC + +++C C
Sbjct: 401 CSSNPCQNGGTCENLPGNYTCHC 423
Score = 153 bits (387), Expect = 3e-36
Identities = 113/357 (31%), Positives = 151/357 (42%), Gaps = 47/357 (13%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
C SN CQN TC + C C D + +S CQ TCVNT G
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNP---CQGSATCVNTPG 90
Query: 196 --SYSCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYS-CVCDAGW 251
S+ C CPP G C + C S C HG IC +P Y C+C AG+
Sbjct: 91 ERSFLCKCPPGYSGTICETTIGSCGKNS---CQHGGICHQ-------DPIYPVCICPAGY 140
Query: 252 MFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEI 311
C +D DEC+ PC C + + C C G+QG C++
Sbjct: 141 A----GRFCEIDHDECA--SSPCQNGAVCQDGIDGYSC-FCVPGYQGR--------HCDL 185
Query: 312 NNGGCSVAP---PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSS 368
C+ P C+N G C CP Y G C L +I + C A+C
Sbjct: 186 EVDECASDPCKNEATCLNEIGRYTC-ICPHNYSGVN--CEL-EIDECWSQPCLNGATCQD 241
Query: 369 TLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYFCKCD-SGWTG 426
LG+ C C PG+ G+ C ++ C S PCL+G C+D + Y C C SG+TG
Sbjct: 242 ALGAY-FCDCAPGFLGDH-----CELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTG 295
Query: 427 VNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGING 483
+C + C S PC N TC D VD+++C C +TGA C++ C + NG
Sbjct: 296 THCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNG 352
Score = 141 bits (355), Expect = 1e-32
Identities = 107/360 (29%), Positives = 153/360 (42%), Gaps = 69/360 (19%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
+QG ++ C+S+PC+N TCLN + CICP + G C +++EC
Sbjct: 178 YQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDEC-----WSQP 232
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPK 242
C NG TC + +G+Y C C P G C D+C + C+H G+C D GE +
Sbjct: 233 CLNGATCQDALGAYFCDCAPGFLGDHCELNTDEC---ASQPCLHGGLCVD------GENR 283
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG-NGY 301
YSC C + C C + PC C ++ ++ C W G G
Sbjct: 284 YSCNCTGSGFTGTH---CETLMPLCWSK--PCHNNATCEDSVDNYTCHC----WPGYTGA 334
Query: 302 ICE-DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC 360
CE D+NEC N+ C ECV GR+ L
Sbjct: 335 QCEIDLNEC--NSNPCQ--SNGECVELSSEKQY----------GRITGL----------- 369
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSG-YFCK 419
+S S S +C C PG+TG C + N C S+PC NG + + G Y C
Sbjct: 370 --PSSFSYHEASGYVCICQPGFTG-----IHCEEDVNECSSNPCQNGGTCENLPGNYTCH 422
Query: 420 CD------SGWTGVNCTENINECLSNPCLNGGTCV----DGVDSFSCECTRLWTGALCQV 469
C + + G +C++ + C CLN GTC+ DG FSC C +TG+LC++
Sbjct: 423 CPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482
Score = 93.6 bits (231), Expect = 3e-18
Identities = 65/207 (31%), Positives = 91/207 (43%), Gaps = 29/207 (14%)
Query: 273 PCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVE--CVNTPGS 330
PC C + S++C +CP GW G CE+N C P + C + +
Sbjct: 1147 PCLHGGNCEDIYSSYHC-SCPLGWSGK--------HCELNIDECFSNPCIHGNCSDRVAA 1197
Query: 331 SHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN 390
HC C PGY G V DI + + C A+C S C C +TG
Sbjct: 1198 YHC-TCEPGYTG---VNCEVDIDNCQSHQCANGATCISHTNGYS-CLCFGNFTGKF---- 1248
Query: 391 GCVQL---SNICLSHP----CLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCL 442
C Q S +C + C NG C + + C C G+TG C ++I+EC S+PC+
Sbjct: 1249 -CRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCV 1307
Query: 443 NGGTCVDGVDSFSCECTRLWTGALCQV 469
NGG C D ++ F C C + G C+V
Sbjct: 1308 NGGLCQDLLNKFQCLCDVAFAGERCEV 1334
Score = 93.2 bits (230), Expect = 4e-18
Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 347 CTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN 406
C ++C+ + C +C S C+C G++G C + C S+PC++
Sbjct: 1137 CLQLNVCN--SNPCLHGGNCEDIYSSYH-CSCPLGWSGKH-----CELNIDECFSNPCIH 1188
Query: 407 GQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGAL 466
G C D V+ Y C C+ G+TGVNC +I+ C S+ C NG TC+ + +SC C +TG
Sbjct: 1189 GNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKF 1248
Query: 467 C---QVPQQVCGESLSGI 481
C ++P VCG + +
Sbjct: 1249 CRQSRLPSTVCGNEKTNL 1266
Score = 76.3 bits (186), Expect = 5e-13
Identities = 60/183 (32%), Positives = 78/183 (42%), Gaps = 29/183 (15%)
Query: 303 CEDINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
C +N C N +GG C + S HC +CP G+ G + C L SN
Sbjct: 1137 CLQLNVCNSNPCLHGG-------NCEDIYSSYHC-SCPLGWSG--KHCELNIDECFSNPC 1186
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ-CIDTVSGYFC 418
H +CS + + CTC PGYTG N V + N C SH C NG CI +GY C
Sbjct: 1187 IH--GNCSDRVAAYH-CTCEPGYTG----VNCEVDIDN-CQSHQCANGATCISHTNGYSC 1238
Query: 419 KCDSGWTGVNCTENI-------NECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQ 471
C +TG C ++ NE + C NGG C + C C +TG C+
Sbjct: 1239 LCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI 1298
Query: 472 QVC 474
C
Sbjct: 1299 DEC 1301
Score = 73.6 bits (179), Expect = 3e-12
Identities = 69/270 (25%), Positives = 98/270 (36%), Gaps = 43/270 (15%)
Query: 113 LNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQ-WKGPLCSADV 171
L + D F G ++ C+S PC +GG C++ + + C C + G C +
Sbjct: 243 LGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLM 302
Query: 172 NECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGG---SVARCVHG 228
C C N TC +++ +Y+CHC P G QC ++C S CV
Sbjct: 303 PLC-----WSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVEL 357
Query: 229 ICEDLMREQAGEPK---------YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQ 279
E G P Y C+C G+ C D +ECS PC
Sbjct: 358 SSEKQYGRITGLPSSFSYHEASGYVCICQPGF----TGIHCEEDVNECS--SNPCQNGGT 411
Query: 280 CFNTQGSFYCGACP----TGWQGNGYICEDI------NECEINNGGCSVAPPVECVNTPG 329
C N G++ C CP + G C DI +C +NNG C +
Sbjct: 412 CENLPGNYTC-HCPFDNLSRTFYGGRDCSDILLGCTHQQC-LNNGTC-----IPHFQDGQ 464
Query: 330 SSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
CP GY G +C + S G
Sbjct: 465 HGFSCLCPSGYTGS--LCEIATTLSFEGDG 492
Score = 72.4 bits (176), Expect = 8e-12
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 29/191 (15%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTM 194
VC+SNPC +GG C +++ S+ C CP W G C +++EC +S + G C + +
Sbjct: 1142 VCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDEC--FSNPCIH----GNCSDRV 1195
Query: 195 GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGW--M 252
+Y C C P G C D+C+ +C +G + G YSC+C +
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQS---HQCANG--ATCISHTNG---YSCLCFGNFTGK 1247
Query: 253 FSPNS--PACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE-DINEC 309
F S P+ ++ + C C Q C C G+ G CE DI+EC
Sbjct: 1248 FCRQSRLPSTVCGNEKTNL---TCYNGGNCTEFQTELKC-MCRPGFTGEW--CEKDIDEC 1301
Query: 310 E----INNGGC 316
+N G C
Sbjct: 1302 ASDPCVNGGLC 1312
Score = 71.2 bits (173), Expect = 2e-11
Identities = 39/134 (29%), Positives = 58/134 (43%), Gaps = 12/134 (8%)
Query: 121 ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSG- 179
E + G+ VD C S+ C NG TC++ + + C+C + G C +
Sbjct: 1203 EPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNE 1262
Query: 180 -TPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQ 237
T L+C NGG C C C P G C D+C CV+ G+C+DL+
Sbjct: 1263 KTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDP---CVNGGLCQDLLN-- 1317
Query: 238 AGEPKYSCVCDAGW 251
K+ C+CD +
Sbjct: 1318 ----KFQCLCDVAF 1327
Score = 65.9 bits (159), Expect = 7e-10
Identities = 62/225 (27%), Positives = 93/225 (41%), Gaps = 44/225 (19%)
Query: 225 CVHG-ICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQP---GPCSTLVQC 280
C+HG CED+ Y C C GW + C L+ DEC P G CS V
Sbjct: 1148 CLHGGNCEDIYSS------YHCSCPLGW----SGKHCELNIDECFSNPCIHGNCSDRV-- 1195
Query: 281 FNTQGSFYCGACPTGWQGNGYICE-DINECEINNGGCSVAPPVECVNTPGSSHCQACPPG 339
+++C C G+ G CE DI+ C+ + A C++ C C
Sbjct: 1196 ----AAYHC-TCEPGYTGVN--CEVDIDNCQSHQ----CANGATCISHTNGYSC-LCFGN 1243
Query: 340 YQGDGRVCTLTDICSVSNGG------CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCV 393
+ G + C + + S G C+ +C+ L C C PG+TG C
Sbjct: 1244 FTG--KFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELK-CMCRPGFTGEW-----CE 1295
Query: 394 QLSNICLSHPCLNGQ-CIDTVSGYFCKCDSGWTGVNCTENINECL 437
+ + C S PC+NG C D ++ + C CD + G C ++ + L
Sbjct: 1296 KDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 53.1 bits (126), Expect = 5e-06
Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 9/87 (10%)
Query: 128 QQTVDKKVCSSNP----CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
Q + VC + C NGG C C+C P + G C D++EC + P
Sbjct: 1251 QSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDEC---ASDP-- 1305
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQC 210
C NGG C + + + C C G +C
Sbjct: 1306 CVNGGLCQDLLNKFQCLCDVAFAGERC 1332
Score = 48.5 bits (114), Expect = 1e-04
Identities = 38/153 (24%), Positives = 60/153 (39%), Gaps = 29/153 (18%)
Query: 47 ERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNI 106
E+G+++++ G E +LN C+ ++ N +++ P N
Sbjct: 825 EKGDVIYIGGLPDKQE--------TELNGGFFKGCIQDVRLNNQNLEFFPN-----PTNN 871
Query: 107 SSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPL 166
+S LN LV++ + G C SNPC NGG C + D F C CP G
Sbjct: 872 AS----LNPVLVNVTQGCAG------DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKA 921
Query: 167 CSADVNECEIYSGTPLSCQNGGTCVNTMGSYSC 199
C +V C C +G C + + C
Sbjct: 922 CE-EVQWCGF-----SPCPHGAQCQPVLQGFEC 948
Score = 46.6 bits (109), Expect = 4e-04
Identities = 25/54 (46%), Positives = 28/54 (51%), Gaps = 4/54 (7%)
Query: 427 VNCTENI---NECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
VN T+ N C SNPC NGG C D FSC C L +G C+ Q CG S
Sbjct: 879 VNVTQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFS 931
Score = 42.7 bits (99), Expect = 0.006
Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 4/107 (3%)
Query: 391 GCVQLSNICLSHPCLNGQ-CIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVD 449
GC N C S+PC NG C + C C + +G C E + C +PC +G C
Sbjct: 884 GCAG-DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQP 941
Query: 450 GVDSFSCECTRLWTGALCQVPQQVCGESLSGI-NGSFSYRSPDVGYV 495
+ F C ++ G Q+ + G + N +F +R+ D +
Sbjct: 942 VLQGFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVI 988
Score = 40.8 bits (94), Expect = 0.025
Identities = 15/36 (41%), Positives = 22/36 (61%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADV 171
C+S+PC NGG C +L + F C+C + G C D+
Sbjct: 1301 CASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDL 1336
Score = 40.0 bits (92), Expect = 0.042
Identities = 17/37 (45%), Positives = 22/37 (59%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLC 167
V K C S PCQ+ G C+NL S+ C C ++GP C
Sbjct: 671 VRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 35.4 bits (80), Expect = 1.0
Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 11/67 (16%)
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPK 242
C NGG C + +SC CP T G C ++ + + C HG C+ +++
Sbjct: 896 CHNGGVCHSRWDDFSCSCPALTSGKAC----EEVQWCGFSPCPHGAQCQPVLQ------G 945
Query: 243 YSCVCDA 249
+ C+ +A
Sbjct: 946 FECIANA 952
Score = 34.3 bits (77), Expect = 2.3
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKY 214
CQ+ G C+N SY C C GP C +Y
Sbjct: 681 CQSRGRCINLWLSYQCDCHRPYEGPNCLREY 711
Score = 33.9 bits (76), Expect = 3.0
Identities = 13/31 (41%), Positives = 15/31 (48%)
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSCECT 459
C +N CLSN C N TC D C C+
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCS 57
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 167 bits (424), Expect = 1e-40
Identities = 134/390 (34%), Positives = 172/390 (44%), Gaps = 71/390 (18%)
Query: 121 ERKFQGLQQTVDKKVCSSNPCQ-NGGTCLNLHDSFFCICPPQWK-GPLCSA--DVNECEI 176
E F ++ +D C +P GG C N S+ C CPP + P SA D+NECE+
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECEL 1161
Query: 177 ------------------------YSGTP----------LSCQNGGT---CVNTMGSYSC 199
Y TP S NGG C N+ GSY C
Sbjct: 1162 SAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYEC 1221
Query: 200 HCPPETY---GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPN 256
C P + + D+CE C G C ++ E Y C+C G+M S +
Sbjct: 1222 SCQPGFALMPDQRSCTDIDECEDNPNI-CDGGQCTNIPGE------YRCLCYDGFMASED 1274
Query: 257 SPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI--CEDINECEINNG 314
C +D +EC P C + C NT+GSF C C G+ G C DINECEI
Sbjct: 1275 MKTC-VDVNECDLNPNICLSGT-CENTKGSFICH-CDMGYSGKKGKTGCTDINECEIGAH 1331
Query: 315 GCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLP 374
C C NT GS C +C PG+ GDG CT D CS C A C +T+GS
Sbjct: 1332 NCG--KHAVCTNTAGSFKC-SCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSY- 1387
Query: 375 LCTCLPGYTGNGYGPNGCVQLSNICLS-HPCLNGQCIDTVSGYFCKCDSGWT----GVNC 429
C C GYTG+G+ C L + + C NGQC++ GY C+CD G+ G C
Sbjct: 1388 RCLCKEGYTGDGF---TCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKAC 1444
Query: 430 TENINEC-LSNPCLNGGTCVDGVDSFSCEC 458
E+I+EC L N C+ GTC + F CEC
Sbjct: 1445 -EDIDECSLPNICV-FGTCHNLPGLFRCEC 1472
Score = 144 bits (364), Expect = 1e-33
Identities = 115/377 (30%), Positives = 171/377 (45%), Gaps = 50/377 (13%)
Query: 145 GTCLNLHDSFFCICPPQWKGPLCSA----DVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
G C+N F C C ++ D++EC+ PL C+ GG C NT GSY C
Sbjct: 1084 GQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQ---RDPLLCR-GGVCHNTEGSYRCE 1139
Query: 201 CPP-ETYGPQCASKYD--DCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNS 257
CPP P ++ D +CE S C +G C +L+ KY C C+ G+ +P+
Sbjct: 1140 CPPGHQLSPNISACIDINECE-LSAHLCPNGRCVNLI------GKYQCACNPGYHSTPDR 1192
Query: 258 PACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECEINNGG 315
C +D DECS G C T C N++GS+ C +C G+ + C DI+ECE N
Sbjct: 1193 LFC-VDIDECSIMNGGCETF--CTNSEGSYEC-SCQPGFALMPDQRSCTDIDECEDNPNI 1248
Query: 316 CSVAPPVECVNTPGSSHCQACPPGYQG--DGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C +C N PG C C G+ D + C + C ++ C +C +T GS
Sbjct: 1249 CDGG---QCTNIPGEYRC-LCYDGFMASEDMKTCVDVNECDLNPNIC-LSGTCENTKGSF 1303
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICL-SHPC-LNGQCIDTVSGYFCKCDSGW--TGVNC 429
+C C GY+G G GC ++ + +H C + C +T + C C GW G+ C
Sbjct: 1304 -ICHCDMGYSGK-KGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKC 1361
Query: 430 TENINECL--SNPCLNGGTCVDGVDSFSCECTRLWTG--------ALCQVPQQVCGESLS 479
T+ ++EC ++ C C + + S+ C C +TG C +CG
Sbjct: 1362 TD-LDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNG-Q 1419
Query: 480 GINGSFSYRSP-DVGYV 495
+N YR D+G+V
Sbjct: 1420 CLNAPGGYRCECDMGFV 1436
Score = 137 bits (345), Expect = 2e-31
Identities = 114/338 (33%), Positives = 154/338 (45%), Gaps = 58/338 (17%)
Query: 141 CQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
CQ GG C+N SF C CP + + DVNECE TP C GTC NT+G+Y
Sbjct: 1617 CQ-GGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECE----TPGIC-GPGTCYNTVGNY 1670
Query: 198 SCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY--SCVCDAGWMFSP 255
+C CPP+ Y GG+ C D+ R Y + CD +F+
Sbjct: 1671 TCICPPD---------YMQVNGGN-------NCMDMRRSLCYRNYYADNQTCDGELLFNM 1714
Query: 256 NSPACTLDRDECSFQPG-----PCSTLVQCFNTQGSFYCGACPTGWQGNGY--ICEDINE 308
C CS+ G PC + + CG+ G+ + Y + DI+E
Sbjct: 1715 TKKMCC-----CSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDE 1769
Query: 309 CEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG-CHPDASCS 367
C G C C+N GS C+ CP G+ + ++ DI NG C +A C
Sbjct: 1770 CREIPGVCENG---VCINMVGSFRCE-CPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI 1825
Query: 368 STLGSLPLCTCLPGY----TGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSG 423
+T GS C C PGY TG N C ++ NIC SH GQCIDTV ++C C +G
Sbjct: 1826 NTAGSY-RCDCKPGYRFTSTGQCNDRNECQEIPNIC-SH----GQCIDTVGSFYCLCHTG 1879
Query: 424 W-TGVNCTE--NINECLSNPCLNGGTCVDGVDSFSCEC 458
+ T + T +INEC + C N GTC + + SF+C C
Sbjct: 1880 FKTNDDQTMCLDINECERDACGN-GTCRNTIGSFNCRC 1916
Score = 130 bits (327), Expect = 2e-29
Identities = 124/424 (29%), Positives = 170/424 (40%), Gaps = 104/424 (24%)
Query: 129 QTVDKKVCS-SNPCQNGGTCLNLHDSFFCICPPQWK-GPLCSA-DVNECEIYSGTPLSCQ 185
+ VD CS NPC NG TC N+ F C C ++ GP+ + D+NEC + PL C
Sbjct: 2163 ECVDTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGPMMTCEDINEC---AQNPLLC- 2217
Query: 186 NGGTCVNTMGSYSCHCPPE---TYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
CVNT GSY C CP + D+CE G H E M +
Sbjct: 2218 -AFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGK-----HDCTEKQMECKNLIGT 2271
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--- 299
Y C+C G+ P+ C +D +EC +PG C +C NT+GS+ C C G+ +
Sbjct: 2272 YMCICGPGYQRRPDGEGC-VDENECQTKPGICEN-GRCLNTRGSYTC-ECNDGFTASPNQ 2328
Query: 300 --------GYICEDI--NECEIN--------------NGG------CSVAP--------- 320
GY ++ N C+I +GG C + P
Sbjct: 2329 DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKK 2388
Query: 321 --------------------------PVECVNTPGSSHCQACPPGYQGD--GRVCTLTDI 352
ECVN GS HC C GY D G C +
Sbjct: 2389 LCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHC-ICKTGYTPDITGTSCVDLNE 2447
Query: 353 CSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDT 412
C+ + C + C +T GS C+C GY G C L C++T
Sbjct: 2448 CNQAPKPC--NFICKNTEGSYQ-CSCPKGYILQEDG-RSCKDLDECATKQHNCQFLCVNT 2503
Query: 413 VSGYFCKCDSGWT--GVNCTENINECLS--NPCLNGGTCVDGVDSFSCECTRLW----TG 464
+ G+ CKC G+T +C +N NEC S N C + G C + SF+CEC R + TG
Sbjct: 2504 IGGFTCKCPPGFTQHHTSCIDN-NECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTG 2562
Query: 465 ALCQ 468
+ C+
Sbjct: 2563 SSCE 2566
Score = 122 bits (305), Expect = 8e-27
Identities = 115/372 (30%), Positives = 156/372 (41%), Gaps = 73/372 (19%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCS-----ADVNECEIYSGTPLSCQ 185
+D C + C NG TC N SF C C G + S DV+EC SG C+
Sbjct: 1890 LDINECERDACGNG-TCRNTIGSFNCRCN---HGFILSHNNDCIDVDECA--SGNGNLCR 1943
Query: 186 NGGTCVNTMGSYSCHCPPETY-----GPQCASKYDDCEGGSVARCVHGICEDLMREQAGE 240
NG C+NT+GS+ C C E Y G C ++C +C G C++L +
Sbjct: 1944 NG-QCINTVGSFQCQCN-EGYEVAPDGRTCVD-INECLL-EPRKCAPGTCQNL------D 1993
Query: 241 PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--G 298
Y C+C G +S + C D DEC +P C+ L C NT+GSF C CP G+
Sbjct: 1994 GSYRCICPPG--YSLQNEKCE-DIDECVEEPEICA-LGTCSNTEGSFKC-LCPEGFSLSS 2048
Query: 299 NGYICEDINE----CEINNGGCSV--------------------APPVE-CVNTPGSSHC 333
+G C+D+ + G CS P E C P +
Sbjct: 2049 SGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFR 2108
Query: 334 QACPPGYQGDGRVCTLTDICSVSNGGC-HPDA----SCSSTLGSLPLCTCLPGYTGNGYG 388
Q CP G + D +V C PD C +T GS C C GY G
Sbjct: 2109 QICPYG----SGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYR-CECPFGYILAG-- 2161
Query: 389 PNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWT--GVNCTENINECLSNPCLNGGT 446
N CV + +PC NG C + + G+ C C+ G+ + E+INEC NP L
Sbjct: 2162 -NECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFR 2220
Query: 447 CVDGVDSFSCEC 458
CV+ S+ C+C
Sbjct: 2221 CVNTYGSYECKC 2232
Score = 120 bits (302), Expect = 2e-26
Identities = 116/364 (31%), Positives = 155/364 (42%), Gaps = 73/364 (20%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCSA--DVNECEIYSGTPLSCQNGGTCVNTMGSYS 198
CQNG C+ S C C ++ L DV+ECE P + GG C+N GSY+
Sbjct: 460 CQNG-RCIPTPGSCRCECNKGFQLDLRGECIDVDECE---KNPCA---GGECINNQGSYT 512
Query: 199 CHCP---PETYGPQCASKYDDC-EGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFS 254
C C T D+C + G + C +G C + + + CVC+AG+ +
Sbjct: 513 CQCRAGYQSTLTRTECRDIDECLQNGRI--CNNGRCINT------DGSFHCVCNAGFHVT 564
Query: 255 PNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GNGYICEDINECEIN 312
+ C D DECS + + + C N GSF C C G+Q +G C+DINECE
Sbjct: 565 RDGKNCE-DMDECSIRNMCLNGM--CINEDGSFKC-ICKPGFQLASDGRYCKDINECE-T 619
Query: 313 NGGCSVAPPVECVNTPGSSHCQACPPGYQG-DGRVCTLTDICSVSNGG------------ 359
G C CVNT GS C+ P G DGRVC T + S GG
Sbjct: 620 PGICMNG---RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676
Query: 360 --CHPDASCSSTLGSL----------------PLCTCLPGYTGNGYGPNGCVQLSNICLS 401
+ C+ST + LC+ PG T G N C +I
Sbjct: 677 AVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDI--- 733
Query: 402 HPCLNGQCIDTVSGYFCKCDSGW----TGVNCTENINECLSNPCL-NGGTCVDGVDSFSC 456
C NG C + Y C C+SG+ TG NC + INEC+ N L + G C + SF C
Sbjct: 734 --CPNGICENLRGTYKCICNSGYEVDSTGKNCVD-INECVLNSLLCDNGQCRNTPGSFVC 790
Query: 457 ECTR 460
C +
Sbjct: 791 TCPK 794
Score = 115 bits (287), Expect = 1e-24
Identities = 114/396 (28%), Positives = 163/396 (41%), Gaps = 90/396 (22%)
Query: 132 DKKVCSSNP--CQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQ 185
D C+ +P C NG C NL ++ CIC ++ G C D+NEC + S L C
Sbjct: 723 DINECALDPDICPNG-ICENLRGTYKCICNSGYEVDSTGKNC-VDINECVLNS---LLCD 777
Query: 186 NGGTCVNTMGSYSCHCPPE-TYGP--QCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
NG C NT GS+ C CP Y P + D+CE C++G+C++
Sbjct: 778 NG-QCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSP---CINGVCKN------SPGS 827
Query: 243 YSCVCDAGWMFSPNSPAC----------TLDRDECSFQPGPCSTLVQCFNTQGSFYCGAC 292
+ C C + P C T+ C + QC ++ G+ + C
Sbjct: 828 FICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPC 887
Query: 293 ------PTGWQG----NGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQG 342
P +G G CEDI+ECE+ G C CVNT GS CQ CP G
Sbjct: 888 TLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGL---CVNTRGSFKCQ-CPSGMTL 943
Query: 343 D--GRVCTLTDI-----------CSVSNGGCHPDASCSSTLGSL---------------- 373
D GR+C + C++ G H +C ++G+
Sbjct: 944 DATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPE 1003
Query: 374 --PLCTCLPGYTGNGYGPNGCVQLSNI--CLSHP--CLNGQCIDTVSGYFCKCDSGWT-- 425
LC PG+ NG +I C P C +G+C +T+ + C+CDSG+
Sbjct: 1004 YEELCPRGPGFATKEI-TNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALD 1062
Query: 426 --GVNCTENINECLSNPCLNG-GTCVDGVDSFSCEC 458
NCT+ I+EC +P L G G CV+ F C+C
Sbjct: 1063 SEERNCTD-IDECRISPDLCGRGQCVNTPGDFECKC 1097
Score = 114 bits (286), Expect = 1e-24
Identities = 125/447 (27%), Positives = 178/447 (39%), Gaps = 96/447 (21%)
Query: 77 DLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLER-KFQGLQQTVDK-K 134
D++ECL +E + A G QN+ + L+ K + + + V++ +
Sbjct: 1973 DINECL----------LEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPE 2022
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQ-NGGTCVNT 193
+C+ GTC N SF C+CP +G S+ C+ + + GG C +
Sbjct: 2023 ICAL------GTCSNTEGSFKCLCP---EGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSP 2073
Query: 194 MG----SYSCHC-----------------PPETYGPQC-------------ASKYDDCEG 219
C C P E + C A D+C+
Sbjct: 2074 KSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKE 2133
Query: 220 GSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQ 279
V C HG C + + Y C C G++ + N +D DECS PC
Sbjct: 2134 PDV--CKHGQCINT------DGSYRCECPFGYILAGNE---CVDTDECSVG-NPCGNGT- 2180
Query: 280 CFNTQGSFYCGACPTGWQ-GNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPP 338
C N G F C C G++ G CEDINEC N C+ CVNT GS C+ CP
Sbjct: 2181 CKNVIGGFEC-TCEEGFEPGPMMTCEDINECAQNPLLCAF----RCVNTYGSYECK-CPV 2234
Query: 339 GY--QGDGRVCTLTDICSVSNGGC-HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQL 395
GY + D R+C D C C C + +G+ +C C PGY G GCV
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTY-MCICGPGYQRRPDG-EGCVD- 2291
Query: 396 SNICLSHP--CLNGQCIDTVSGYFCKCDSGWTGV----NCTEN-----INECLSNPCLNG 444
N C + P C NG+C++T Y C+C+ G+T C +N E L N C G
Sbjct: 2292 ENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIG 2351
Query: 445 GTCVDGVDSFSCECT--RLWTGALCQV 469
+ + V C C R W G C++
Sbjct: 2352 SSNRNPVTKSECCCDGGRGW-GPHCEI 2377
Score = 112 bits (281), Expect = 5e-24
Identities = 108/348 (31%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICP-----------PQWKGPLCS-ADVNECEIYSGTPL 182
V S C +GG H ICP P +G + + AD++EC++
Sbjct: 2358 VTKSECCCDGGRGWGPHCE---ICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDV-- 2412
Query: 183 SCQNGGTCVNTMGSYSCHCP----PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQA 238
C+NG CVN GSY C C P+ G C D E + + IC++
Sbjct: 2413 -CRNG-ECVNDRGSYHCICKTGYTPDITGTSCV---DLNECNQAPKPCNFICKNT----- 2462
Query: 239 GEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG 298
E Y C C G++ + +C D DEC+ + C L C NT G F C CP G+
Sbjct: 2463 -EGSYQCSCPKGYILQEDGRSCK-DLDECATKQHNCQFL--CVNTIGGFTC-KCPPGFTQ 2517
Query: 299 NGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD--GRVCTLTDICSVS 356
+ C D NEC + C C NTPGS C+ C G+ D G C D C +
Sbjct: 2518 HHTSCIDNNECTSDINLCGSKGI--CQNTPGSFTCE-CQRGFSLDQTGSSCEDVDECEGN 2574
Query: 357 NGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLS-HPCLNGQCIDTVSG 415
+ H C + +G C+C GY + Y N CV N CLS H C C +T+
Sbjct: 2575 HRCQH---GCQNIIGGYR-CSCPQGYLQH-YQWNQCVD-ENECLSAHICGGASCHNTLGS 2628
Query: 416 YFCKCDSGWTGVNCT---ENINECLS--NPCLNGGTCVDGVDSFSCEC 458
Y C C +G+ + ++INEC S PC G C + + C C
Sbjct: 2629 YKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLCGC 2674
Score = 110 bits (275), Expect = 3e-23
Identities = 117/397 (29%), Positives = 153/397 (38%), Gaps = 103/397 (25%)
Query: 145 GTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
GTC NL F C C ++ G C+ DVNEC P +C +G CVNT GSY C
Sbjct: 1459 GTCHNLPGLFRCECEIGYELDRSGGNCT-DVNECL----DPTTCISGN-CVNTPGSYICD 1512
Query: 201 CPP------------ETYGPQC-------------ASKYDDCEGGSVARCVHGI------ 229
CPP +T C A + G S A C +
Sbjct: 1513 CPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGT 1572
Query: 230 -CEDLMREQAGEPKYSCVCDAGWMFSPNSPACTL-DRDECSFQPGPCSTLVQCFNTQGSF 287
CE M +Y +C G F PN L D DEC PG C +C NT GSF
Sbjct: 1573 PCE--MCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQG-GKCINTFGSF 1629
Query: 288 YCGACPTGWQGN--GYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPP------- 338
C CPTG+ N +C+D+NECE + P C NT G+ C CPP
Sbjct: 1630 QC-RCPTGYYLNEDTRVCDDVNECETP----GICGPGTCYNTVGNYTC-ICPPDYMQVNG 1683
Query: 339 --------------GYQGDGRVC--------TLTDICSVSNGGCHPDASCS-----STLG 371
Y D + C T C N G + C ST
Sbjct: 1684 GNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDE 1743
Query: 372 SLPLC-TCLPG-----YTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW- 424
LC + PG YTG + C ++ + C NG CI+ V + C+C G+
Sbjct: 1744 FATLCGSQRPGFVIDIYTGLPVDIDECREIPGV-----CENGVCINMVGSFRCECPVGFF 1798
Query: 425 --TGVNCTENINECLSNP-CLNGGTCVDGVDSFSCEC 458
+ E+I+EC + P C C++ S+ C+C
Sbjct: 1799 YNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDC 1835
Score = 104 bits (259), Expect = 2e-21
Identities = 110/348 (31%), Positives = 143/348 (41%), Gaps = 61/348 (17%)
Query: 116 KLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICP----PQWKGPLCSADV 171
KL R F +D+ + C+NG C+N S+ CIC P G C D+
Sbjct: 2388 KLCPHGRGFMTNGADIDECKVIHDVCRNG-ECVNDRGSYHCICKTGYTPDITGTSC-VDL 2445
Query: 172 NECEIYSGTPLSCQNGGTCVNTMGSYSCHCPP----ETYGPQCASKYDDCEGGSVARCVH 227
NEC + P C C NT GSY C CP + G C D+C A H
Sbjct: 2446 NEC---NQAPKPCNF--ICKNTEGSYQCSCPKGYILQEDGRSCKD-LDEC-----ATKQH 2494
Query: 228 GICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSF 287
C+ L G ++C C G F+ + +C +D +EC+ C + C NT GSF
Sbjct: 2495 N-CQFLCVNTIGG--FTCKCPPG--FTQHHTSC-IDNNECTSDINLCGSKGICQNTPGSF 2548
Query: 288 YCGACPTGWQ--GNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQG--- 342
C C G+ G CED++ECE N C C N G C +CP GY
Sbjct: 2549 TC-ECQRGFSLDQTGSSCEDVDECE-GNHRCQHG----CQNIIGGYRC-SCPQGYLQHYQ 2601
Query: 343 -----DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSN 397
D C IC GG ASC +TLGS C C G+ + GC + N
Sbjct: 2602 WNQCVDENECLSAHIC----GG----ASCHNTLGSYK-CMCPAGFQYEQFS-GGCQDI-N 2650
Query: 398 ICLSH--PCLNGQCIDTVSGYFCKCDSGWTGV---NCTENINECLSNP 440
C S PC G C +T GY C C G+ + +C + NP
Sbjct: 2651 ECGSAQAPCSYG-CSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNP 2697
Score = 103 bits (256), Expect = 4e-21
Identities = 110/393 (27%), Positives = 147/393 (37%), Gaps = 83/393 (21%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC 190
+++ V +S C NG C N SF C CP KG + D+ CE S G C
Sbjct: 766 INECVLNSLLCDNG-QCRNTPGSFVCTCP---KGFIYKPDLKTCEDIDECESSPCINGVC 821
Query: 191 VNTMGSYSCHCPPE-TYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDA 249
N+ GS+ C C E T P + +G + G CE + K C
Sbjct: 822 KNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCE--ININGATLKSQCCSSL 879
Query: 250 GWMFSPNSPACTLDR-----------------DECSFQPGPCSTLVQCFNTQGSFYCGAC 292
G + C +D DEC PG C + C NT+GSF C C
Sbjct: 880 GAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGL-CVNTRGSFKC-QC 937
Query: 293 PTGW--QGNGYICEDIN-----------ECEINNGG--------CSVAPPVECVNTPGSS 331
P+G G IC DI EC + G CSV G+
Sbjct: 938 PSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAW------GTE 991
Query: 332 HCQACP----PGYQ-----GDGRVCT--------LTDI--CSVSNGGCHPDASCSSTLGS 372
C+ CP P Y+ G G DI C + C C +T+GS
Sbjct: 992 ECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLC-THGKCRNTIGS 1050
Query: 373 LPLCTCLPGYTGNGYGPNGCVQLSNICLSHP-CLNGQCIDTVSGYFCKCDSGWTG----- 426
C C G+ + N C + +S C GQC++T + CKCD G+
Sbjct: 1051 FK-CRCDSGFALDSEERN-CTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMM 1108
Query: 427 VNCTENINECLSNPCL-NGGTCVDGVDSFSCEC 458
NC + I+EC +P L GG C + S+ CEC
Sbjct: 1109 KNCMD-IDECQRDPLLCRGGVCHNTEGSYRCEC 1140
Score = 101 bits (251), Expect = 2e-20
Identities = 118/392 (30%), Positives = 160/392 (40%), Gaps = 78/392 (19%)
Query: 126 GLQQTVDKKVCSS-------NPCQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNEC 174
G T D K C N C NG C+N SF CIC P ++ G C D+NEC
Sbjct: 560 GFHVTRDGKNCEDMDECSIRNMCLNG-MCINEDGSFKCICKPGFQLASDGRYCK-DINEC 617
Query: 175 EIYSGTPLSCQNGGTCVNTMGSYSCHCPPETY----GPQCASKY--DDCEGGSVARCVHG 228
E TP C NG CVNT GSY C C P G C + C GG
Sbjct: 618 E----TPGICMNG-RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGG-------- 664
Query: 229 ICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFY 288
R Q +P + V + C E +F PC C + Y
Sbjct: 665 ----YKRGQCIKPLFGAVTKS---------ECCCASTEYAFGE-PCQP---CPAQNSAEY 707
Query: 289 CGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD--GRV 346
C +G G DINEC ++ C P C N G+ C C GY+ D G+
Sbjct: 708 QALCSSG-PGMTSAGSDINECALDPDIC---PNGICENLRGTYKC-ICNSGYEVDSTGKN 762
Query: 347 CTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN--GCVQLSNICLSHPC 404
C + C +++ C + C +T GS +CTC G+ Y P+ C + C S PC
Sbjct: 763 CVDINECVLNSLLCD-NGQCRNTPGSF-VCTCPKGFI---YKPDLKTCEDIDE-CESSPC 816
Query: 405 LNGQCIDTVSGYFCKCDSGWTGVNCTENI-NECLSNPC---LNGGTC---VDGVDSFSCE 457
+NG C ++ + C+C S T ++ T+ I E + C + G C ++G S
Sbjct: 817 INGVCKNSPGSFICECSSEST-LDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQC 875
Query: 458 CTRLWTG-----ALCQVPQQVCGESLSGINGS 484
C+ L LCQV +CG+ S I G+
Sbjct: 876 CSSLGAAWGSPCTLCQV-DPICGKGYSRIKGT 906
Score = 98.2 bits (243), Expect = 1e-19
Identities = 107/373 (28%), Positives = 143/373 (38%), Gaps = 56/373 (15%)
Query: 126 GLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQ 185
G Q VD+ CQ GG C+N SF C CP K S + + S P C+
Sbjct: 242 GACQDVDECQAIPGLCQ-GGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICE 300
Query: 186 NGGTCVNTMGSYSCHCPPETY-GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
GG C NT+ SY C CPP Y P D G +G C + + + K
Sbjct: 301 -GGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSI--TKMQ 357
Query: 245 CVCDAGWMFSPN----SPACTLDRDE-----CS----------FQPGPCSTLVQCFNTQG 285
C CDAG +SP C + E CS + P P +
Sbjct: 358 CCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPP 417
Query: 286 SFYCG-ACPTGWQGNGYICED-----------INECEINNGGCSVAPPVECVNTPGSSHC 333
F G P Y+ + C++ C C+ TPGS C
Sbjct: 418 GFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNG---RCIPTPGSCRC 474
Query: 334 QACPPGYQGDGR-VCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGC 392
+ C G+Q D R C D C C C + GS C C GY C
Sbjct: 475 E-CNKGFQLDLRGECIDVDEC--EKNPC-AGGECINNQGSY-TCQCRAGYQST-LTRTEC 528
Query: 393 VQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW----TGVNCTENINEC-LSNPCLNGG 445
+ CL + C NG+CI+T + C C++G+ G NC E+++EC + N CLN G
Sbjct: 529 RDIDE-CLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNC-EDMDECSIRNMCLN-G 585
Query: 446 TCVDGVDSFSCEC 458
C++ SF C C
Sbjct: 586 MCINEDGSFKCIC 598
Score = 68.2 bits (165), Expect = 1e-10
Identities = 84/333 (25%), Positives = 115/333 (34%), Gaps = 74/333 (22%)
Query: 156 CICPPQWKGPLC-SADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKY 214
C CP P C S + C I C NGG+C + C C G C
Sbjct: 100 CTCPSGQIAPSCGSRSIQHCNI------RCMNGGSCSDD----HCLCQKGYIGTHCGQPV 149
Query: 215 DDCEGGSV--ARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPG 272
CE G + RCV C C G+ P C D ++ G
Sbjct: 150 --CESGCLNGGRCV--------------APNRCACTYGF----TGPQCERD-----YRTG 184
Query: 273 PCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSH 332
PC T++ QG Q +G +C C G + P C P H
Sbjct: 185 PCFTVISNQMCQG-----------QLSGIVCTKTLCCA--TVGRAWGHP--CEMCPAQPH 229
Query: 333 CQACPPGYQGDGRV--CTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN 390
C G+ + R C D C G C +C +T+GS C C G+ N
Sbjct: 230 --PCRRGFIPNIRTGACQDVDECQAIPGLCQ-GGNCINTVGSFE-CKCPAGHKLNEVSQK 285
Query: 391 GCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW----TGVNCTENINECLSNPCLNG 444
C + C + P C G+C +TVS YFCKC G+ G C + + L
Sbjct: 286 -CEDIDE-CSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCID-VRPGYCYTALTN 342
Query: 445 GTCVDGVD------SFSCECTRLWTGALCQVPQ 471
G C + + C+ R W+ + P+
Sbjct: 343 GRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPE 375
Score = 63.2 bits (152), Expect = 5e-09
Identities = 70/269 (26%), Positives = 95/269 (35%), Gaps = 67/269 (24%)
Query: 242 KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGY 301
+Y+ C GW P C + S G CS C CP+G
Sbjct: 62 RYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMC----------TCPSGQIAPSC 111
Query: 302 ICEDINECEI---NNGGCSVAPPVECVNTPG--SSHC--QACPPGYQGDGRVCTLTDICS 354
I C I N G CS C+ G +HC C G GR C + C+
Sbjct: 112 GSRSIQHCNIRCMNGGSCS---DDHCLCQKGYIGTHCGQPVCESGCLNGGR-CVAPNRCA 167
Query: 355 ----------------------VSNGGCHPDAS--------CSSTLG-----SLPLCTCL 379
+SN C S C +T+G +C
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Query: 380 PGYTGNGYGPN---GCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW----TGVNCT 430
P G+ PN G Q + C + P C G CI+TV + CKC +G C
Sbjct: 228 PHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKC- 286
Query: 431 ENINECLSNPCL-NGGTCVDGVDSFSCEC 458
E+I+EC + P + GG C + V S+ C+C
Sbjct: 287 EDIDECSTIPGICEGGECTNTVSSYFCKC 315
Score = 49.7 bits (117), Expect = 5e-05
Identities = 45/142 (31%), Positives = 58/142 (40%), Gaps = 27/142 (19%)
Query: 67 SLGKIKLNDEDLSECL--HQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKF 124
SL + + ED+ EC H+ Q ++II G PQ Q YQ N
Sbjct: 2557 SLDQTGSSCEDVDECEGNHRCQHGCQNIIG--GYRCSCPQGYL-QHYQWN---------- 2603
Query: 125 QGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSA---DVNECEIYSGTP 181
Q VD+ C S G +C N S+ C+CP ++ S D+NEC
Sbjct: 2604 ----QCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINEC---GSAQ 2656
Query: 182 LSCQNGGTCVNTMGSYSCHCPP 203
C G C NT G Y C CPP
Sbjct: 2657 APCSYG--CSNTEGGYLCGCPP 2676
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 155 bits (392), Expect = 7e-37
Identities = 103/326 (31%), Positives = 147/326 (45%), Gaps = 59/326 (18%)
Query: 157 ICPPQWKGPLCSADV--NECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKY 214
+C P WKGP C+ + C+ G C G C +G +C
Sbjct: 211 VCNPGWKGPYCTEPICLPGCDEQHGF---CDKPGECKCRVGWQGRYC------------- 254
Query: 215 DDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPC 274
D+C C+HG C+ + C C GW C D + C+ PC
Sbjct: 255 DECI--RYPGCLHGTCQQ---------PWQCNCQEGW----GGLFCNQDLNYCTHHK-PC 298
Query: 275 STLVQCFNT-QGSFYCGACPTGWQGNGYICE-DINECE---INNGGCSVAPPVECVNTPG 329
C NT QGS+ C +C G+ G CE I+EC+ NGG C +
Sbjct: 299 KNGATCTNTGQGSYTC-SCRPGY--TGATCELGIDECDPSPCKNGG-------SCTDLEN 348
Query: 330 SSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGP 389
S C CPPG+ G ++C L+ + + ++G C CS + C C GY+G
Sbjct: 349 SYSC-TCPPGFYG--KICELSAM-TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFN--- 401
Query: 390 NGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCV 448
C + + C S PC NG +C+D Y C+C +G++G +C +N+++C S+PC NGGTC
Sbjct: 402 --CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCR 459
Query: 449 DGVDSFSCECTRLWTGALCQVPQQVC 474
DGV+ FSC C +TG C P C
Sbjct: 460 DGVNDFSCTCPPGYTGRNCSAPVSRC 485
Score = 113 bits (283), Expect = 3e-24
Identities = 89/303 (29%), Positives = 121/303 (39%), Gaps = 44/303 (14%)
Query: 145 GTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNT-MGSYSCHCPP 203
GTC + C C W G C+ D+N C + C+NG TC NT GSY+C C P
Sbjct: 266 GTC---QQPWQCNCQEGWGGLFCNQDLNYCTHHK----PCKNGATCTNTGQGSYTCSCRP 318
Query: 204 ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLD 263
G C D+C+ G C DL E YSC C G+ C L
Sbjct: 319 GYTGATCELGIDECDPSPCKN--GGSCTDL------ENSYSCTCPPGFY----GKICELS 366
Query: 264 RDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAP--- 320
C+ GPC +C ++ Y CP G+ G CE CS +P
Sbjct: 367 AMTCA--DGPCFNGGRCSDSPDGGYSCRCPVGYSG--------FNCEKKIDYCSSSPCSN 416
Query: 321 PVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLP 380
+CV+ G ++ C G+ GR C ++ ++ C +C + CTC P
Sbjct: 417 GAKCVDL-GDAYLCRCQAGF--SGRHCD-DNVDDCASSPCANGGTCRDGVNDFS-CTCPP 471
Query: 381 GYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSN 439
GYTG C + C PC NG C + Y C+C G+ G NC + E
Sbjct: 472 GYTG-----RNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526
Query: 440 PCL 442
P +
Sbjct: 527 PAV 529
Score = 112 bits (279), Expect = 9e-24
Identities = 82/265 (30%), Positives = 112/265 (42%), Gaps = 39/265 (14%)
Query: 126 GLQQTVDKKVCSSN-PCQNGGTCLNL-HDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
GL D C+ + PC+NG TC N S+ C C P + G C ++EC+ P
Sbjct: 282 GLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD-----PSP 336
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPK 242
C+NGG+C + SYSC CPP YG C C G C + G C D + +
Sbjct: 337 CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP---CFNGGRCSD-----SPDGG 388
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
YSC C G+ + C D CS PCS +C + ++ C C G+ G
Sbjct: 389 YSCRCPVGY----SGFNCEKKIDYCS--SSPCSNGAKCVDLGDAYLC-RCQAGFSG---- 437
Query: 303 CEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
C+ N C+ +P C + C CPPGY GR C+ + +
Sbjct: 438 ----RHCDDNVDDCASSPCANGGTCRDGVNDFSC-TCPPGY--TGRNCS-APVSRCEHAP 489
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTG 384
CH A+C G +C C GY G
Sbjct: 490 CHNGATCHER-GHRYVCECARGYGG 513
Score = 106 bits (264), Expect = 5e-22
Identities = 91/283 (32%), Positives = 117/283 (41%), Gaps = 50/283 (17%)
Query: 201 CPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPAC 260
C P GP C C G + HG C+ + GE C C GW C
Sbjct: 212 CNPGWKGPYCTEPI--CLPGCDEQ--HGFCD-----KPGE----CKCRVGWQ----GRYC 254
Query: 261 TLDRDECSFQPGPCSTLVQCFN--TQGSFYCGACPTGWQGNGYIC-EDINECEINNGGCS 317
DEC PG C + Q + C C GW G C +D+N C ++ C
Sbjct: 255 ----DECIRYPG-------CLHGTCQQPWQCN-CQEGW--GGLFCNQDLNYCT-HHKPCK 299
Query: 318 VAPPVECVNTPGSSHCQACPPGYQGDGRVCTL-TDICSVSNGGCHPDASCSSTLGSLPLC 376
C NT S+ +C PGY G C L D C S C SC+ S C
Sbjct: 300 NG--ATCTNTGQGSYTCSCRPGYTG--ATCELGIDECDPSP--CKNGGSCTDLENSYS-C 352
Query: 377 TCLPGYTGNGYGPNGCVQLSNICLSHPCLNG-QCIDTVSG-YFCKCDSGWTGVNCTENIN 434
TC PG+ G C + C PC NG +C D+ G Y C+C G++G NC + I+
Sbjct: 353 TCPPGFYGKI-----CELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID 407
Query: 435 ECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGES 477
C S+PC NG CVD D++ C C ++G C C S
Sbjct: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450
Score = 91.3 bits (225), Expect = 2e-17
Identities = 75/220 (34%), Positives = 93/220 (42%), Gaps = 40/220 (18%)
Query: 285 GSFYCG-----ACPTGWQGNGYICEDI--NECEINNGGCSVAPPVECVNTPGSSHCQACP 337
G F CG C GW+G Y E I C+ +G C P EC C
Sbjct: 200 GHFTCGERGEKVCNPGWKGP-YCTEPICLPGCDEQHGFCD--KPGEC----------KCR 246
Query: 338 PGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSN 397
G+QG R C D C G H +C C C G+G C Q N
Sbjct: 247 VGWQG--RYC---DECIRYPGCLH--GTCQQPWQ----CNCQ-----EGWGGLFCNQDLN 290
Query: 398 ICLSH-PCLNGQ-CIDTVSG-YFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSF 454
C H PC NG C +T G Y C C G+TG C I+EC +PC NGG+C D +S+
Sbjct: 291 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY 350
Query: 455 SCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGY 494
SC C + G +C++ C + NG SPD GY
Sbjct: 351 SCTCPPGFYGKICELSAMTCADG-PCFNGGRCSDSPDGGY 389
Score = 89.4 bits (220), Expect = 6e-17
Identities = 68/225 (30%), Positives = 93/225 (41%), Gaps = 31/225 (13%)
Query: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTM- 194
C +PC+NGG+C +L +S+ C CPP + G +C C C NGG C ++
Sbjct: 332 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-----ADGPCFNGGRCSDSPD 386
Query: 195 GSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGI-CEDLMREQAGEPKYSCVCDAGWMF 253
G YSC CP G C K D C S + C +G C DL Y C C AG+
Sbjct: 387 GGYSCRCPVGYSGFNCEKKIDYC---SSSPCSNGAKCVDL------GDAYLCRCQAGF-- 435
Query: 254 SPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECE--- 310
+ C + D+C+ PC+ C + F C CP G+ G ++ CE
Sbjct: 436 --SGRHCDDNVDDCA--SSPCANGGTCRDGVNDFSC-TCPPGYTGRN-CSAPVSRCEHAP 489
Query: 311 INNGGC----SVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTD 351
+NG EC G +CQ P V LT+
Sbjct: 490 CHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTE 534
Score = 70.9 bits (172), Expect = 2e-11
Identities = 50/176 (28%), Positives = 67/176 (38%), Gaps = 21/176 (11%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHD-SFFCICPPQWKGPLCSADVNECEIYSGTPL 182
F G + C+ PC NGG C + D + C CP + G C ++ C S +P
Sbjct: 358 FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC---SSSP- 413
Query: 183 SCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
C NG CV+ +Y C C G C DDC A G C D G
Sbjct: 414 -CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN--GGTCRD------GVND 464
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG 298
+SC C G+ C+ C + PC C + +G Y C G+ G
Sbjct: 465 FSCTCPPGY----TGRNCSAPVSRC--EHAPCHNGATC-HERGHRYVCECARGYGG 513
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 149 bits (377), Expect = 4e-35
Identities = 83/234 (35%), Positives = 124/234 (52%), Gaps = 12/234 (5%)
Query: 817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVE 875
CG LTGE G I S FP VYP C W I P+ +V++LNF ++ S C D+V+
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 876 IGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE------D 929
+ + G ++CGT P + S N + V + ++T +GFMA FSA D
Sbjct: 93 VYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 930 LACGEILTESTGTIQSPGHPN-VYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTND 988
CG +L +G+ ++P P+ YP G+ C WHI+ N LI L FE F +E C D
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Query: 989 YLEVY---DTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
Y+ V+ + + +G+YCG S P + S N L++ F++D L +GF+ +Y
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 142 bits (359), Expect = 5e-33
Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 10/242 (4%)
Query: 3034 IISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSH 3093
+ +CGG+ SG I S + YP + C + ITV + KV+ L F D+ C +
Sbjct: 30 VFTCGGILTGESGFIGSEGFPGV-YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY 88
Query: 3094 DYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGP 3153
D++ +Y+G + + +G+FCG+ RP + SS N M++ +D+ G+ F
Sbjct: 89 DFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPN 147
Query: 3154 QQG---CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAS 3210
++G CGG L + +F +P+ Y + CVW I+AP N++I L F F +E +
Sbjct: 148 ERGDQYCGGLLDRPSGSFKTPNWPDRD-YPAGVTCVWHIVAPKNQLIELKFEKFDVERDN 206
Query: 3211 TRQRCLYDYVKLYDGDSEN-ANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269
C YDYV +++G N A G +CG + PAP +S N L +QF+SDL+L +GF
Sbjct: 207 Y---CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIG 263
Query: 3270 TY 3271
Y
Sbjct: 264 HY 265
Score = 125 bits (313), Expect = 1e-27
Identities = 81/247 (32%), Positives = 119/247 (48%), Gaps = 15/247 (6%)
Query: 1606 SRQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT 1665
SRQ R F CGG ILT + S FP YP N C+W I P + L+F
Sbjct: 21 SRQQSPERPVF--TCGG-ILTGESGFIGSEGFPGVYPPNSKCTWKITV-PEGKVVVLNFR 76
Query: 1666 HFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAG 1725
+LE C DFV++ +G H + GR+CGT P + S + + ++ +SD++ +
Sbjct: 77 FIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN 135
Query: 1726 GFHTTVTASV------SACGGTFYMAEGIFNSPGYPD-IYPPNVECVWNIVSSPGNRLQL 1778
GF +A+ CGG G F +P +PD YP V CVW+IV+ ++L
Sbjct: 136 GFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIEL 195
Query: 1779 SFISFQLEDSQDCSRDFVEIREGNAT--GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDG 1836
F F +E C D+V + G +G+YCG+S P S + L ++F+SD
Sbjct: 196 KFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVS-ERNELLIQFLSDL 254
Query: 1837 SGSGTGF 1843
S + GF
Sbjct: 255 SLTADGF 261
Score = 124 bits (312), Expect = 1e-27
Identities = 73/234 (31%), Positives = 110/234 (47%), Gaps = 12/234 (5%)
Query: 1735 VSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRD 1794
V CGG G S G+P +YPPN +C W I G + L+F LE C D
Sbjct: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
Query: 1795 FVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGND 1854
FV++ G+A G +GR+CG P S G+ + V+ ISD + +G GF A F N+
Sbjct: 90 FVDVYNGHANGQRIGRFCGTFRPGALVS-SGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
Query: 1855 N--------IVGTHGKVASPFWPE-NYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNC 1905
+ G +P WP+ +YP W + + ++ + + D+E C
Sbjct: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
Query: 1906 YYDKLRIYDGPSIH-ARLIGAYCGTQTES-FSSTGNSLTFHFYSDSSISGKGFL 1957
YD + +++G ++ AR IG YCG + S N L F SD S++ GF+
Sbjct: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
Score = 123 bits (309), Expect = 3e-27
Identities = 76/237 (32%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 1388 VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFD 1447
V+ CGG L+G +G S GFP YPPN +C W I G + L D+E + C +D
Sbjct: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
Query: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507
+++Y G + RI + C P + S+GN++ ++ +D + G GF A + A
Sbjct: 90 FVDVYNG-HANGQRIGRFC---GTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
Query: 1508 GG------CGGIFQAPSGEIHSPNYPS-PYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
CGG+ PSG +PN+P Y + C W I +N + L F FD+E
Sbjct: 146 PNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERD 205
Query: 1561 DSCIMAY-----DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGF 1612
+ C Y G + R+ + CG A PIVS N L ++F S S GF
Sbjct: 206 NYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA-PIVSERNELLIQFLSDLSLTADGF 261
Score = 122 bits (307), Expect = 5e-27
Identities = 76/245 (31%), Positives = 116/245 (47%), Gaps = 9/245 (3%)
Query: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529
P CG L+G +G Y + C W I GKV+ + F F LES + C +
Sbjct: 29 PVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY 88
Query: 530 EFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPE 589
+F+ VY+G ++ ++GRFCG+ P L+SS N + + S+ G GF + +P
Sbjct: 89 DFVDVYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPN 147
Query: 590 ------CGGILTGPYGSIKSPGYPG-NYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD 642
CGG+L P GS K+P +P +YP G CVW +V + L+ F +E +
Sbjct: 148 ERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNY 207
Query: 643 CNKDYLEIRDGPLYQDP-LLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT 701
C DY+ + +G D +GK+C P+ + I F SD ++ GF Y+
Sbjct: 208 CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIF 267
Query: 702 SPSDL 706
P L
Sbjct: 268 RPKKL 272
Score = 122 bits (307), Expect = 5e-27
Identities = 69/239 (28%), Positives = 113/239 (47%), Gaps = 11/239 (4%)
Query: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
CGGI G+SG I S +P Y + C+ + P+G + L F D+E C +D V
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLG---- 2804
V NG + IG++CG P + S N+++V SD + G GF A ++
Sbjct: 93 VYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 2805 --CGGIFHSDNGTIRSPHWP-QNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQ 2861
CGG+ +G+ ++P+WP +++P C W + K++ +E+ F+ D C+
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEK--FDVERDNYCR 209
Query: 2862 NSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFVSR 2919
+V V+ G E D + CG+ P P+++ N F S A GF ++ R
Sbjct: 210 YDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFR 268
Score = 122 bits (307), Expect = 5e-27
Identities = 72/235 (30%), Positives = 118/235 (50%), Gaps = 10/235 (4%)
Query: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395
CGG + G+SG + S G P + Y N C W + G + ++F +L++ + C DFV
Sbjct: 33 CGGILTGESGFIGSEGFPGV-YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
Query: 2396 EIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRF------ESSM 2449
++++ H +G +GR+CG P ++ +S N +V+ ++D + +GF F E
Sbjct: 92 DVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 2450 EECGGDLQGSIGTFTSPNYPNPN-PHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNE 2508
+ CGG L G+F +PN+P+ + P G C W I AP+ + I L F + C +
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Query: 2509 HVIVFNGIRSN-SPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
+V VFNG N + ++ K C + I S N + + F +D S GF Y
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGD-SPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 122 bits (307), Expect = 5e-27
Identities = 82/233 (35%), Positives = 115/233 (49%), Gaps = 19/233 (8%)
Query: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IM 1565
CGGI SG I S +P Y N+ C+W I V V+LNF DLE + C +
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 1566 AYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQA------ 1619
Y+G ++ R+ R CG + +VSSGN + ++ S + GF A F A
Sbjct: 93 VYNGHANGQ-RIGRFCGTFR-PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
Query: 1620 ---CGGHILTSSFDTVSSPRFP-ANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTC 1675
CGG +L + +P +P +YP C W I A P I L F F++ER C
Sbjct: 151 DQYCGG-LLDRPSGSFKTPNWPDRDYPAGVTCVWHIVA-PKNQLIELKFEKFDVERDNYC 208
Query: 1676 ARDFVEILDGGH-EDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF 1727
D+V + +GG DA G+YCG P PI S + L ++F+SD S++A GF
Sbjct: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
Score = 119 bits (298), Expect = 5e-26
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 12/236 (5%)
Query: 932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLE 991
CG ILT +G I S G P VYP CTW I V ++ L F LE C D+++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 992 VYDTDSE-TSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQ 1050
VY+ + +GR+CG P +L SSGN +M+ ++D++ A GF+ + A Q
Sbjct: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
Query: 1051 DYTDDL-----GTFTSPNFPN-NYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT 1104
Y L G+F +PN+P+ +YP C++ I QLI + F F +E NY
Sbjct: 153 -YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVER--DNYCR 209
Query: 1105 -DFLEIRDGG-YEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
D++ + +GG + +G + G + P I+S N+L ++F SD T GF ++
Sbjct: 210 YDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 117 bits (294), Expect = 2e-25
Identities = 65/222 (29%), Positives = 115/222 (51%), Gaps = 10/222 (4%)
Query: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
G + S G+P Y + CT +T P+ + L F + +E+ CR DF++V NG ++N
Sbjct: 42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANG 100
Query: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG------CGGTLYG 3517
+G++CGT P + S N++ ++ SD+ T+ G+ +++++ CGG L
Sbjct: 101 QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDR 160
Query: 3518 DRGSFTSPGYPG-TYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPN 3576
GSF +P +P YP C W +VAP +L+ + F ++ C +Y+ +++G
Sbjct: 161 PSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGE 220
Query: 3577 ASSPSS-GPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
+ G YC GD+ AP V+ N++ I+F +D + F
Sbjct: 221 VNDARRIGKYC-GDSPPAPIVSERNELLIQFLSDLSLTADGF 261
Score = 114 bits (284), Expect = 2e-24
Identities = 80/248 (32%), Positives = 119/248 (47%), Gaps = 21/248 (8%)
Query: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
+CGG L + G I S +P YP N C+W + V G + ++F F D+ C
Sbjct: 32 TCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFR--FIDLESDNLCRY- 88
Query: 2151 DYLVLRNGPDICSPPLGPPGGN--GHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKI 2208
D++ + N G G G FCG+ L +S N+M VQ ISD + G GF
Sbjct: 89 DFVDVYN---------GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMA 139
Query: 2209 KYEAKSLACGGNVY---IHDADSAGYVTSPNHP-HNYPPHADCIWILAAPPETRIQLQFE 2264
+ A G+ Y + D S + T PN P +YP C+W + AP I+L+FE
Sbjct: 140 MFSAAEPNERGDQYCGGLLDRPSGSFKT-PNWPDRDYPAGVTCVWHIVAPKNQLIELKFE 198
Query: 2265 DRFDIEVTPNCTSNYLELRDGVD-SDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
+FD+E C +Y+ + +G + +DA + K+CG S P+ S + ++F SD S T
Sbjct: 199 -KFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLT 257
Query: 2324 HVGFKAKY 2331
GF Y
Sbjct: 258 ADGFIGHY 265
Score = 111 bits (277), Expect = 1e-23
Identities = 81/261 (31%), Positives = 122/261 (46%), Gaps = 21/261 (8%)
Query: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
+ G G + S +P YP NS W + V VV +D+E C YD + +Y+G
Sbjct: 37 LTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG 96
Query: 1916 PSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIA 1974
+ + + IG +CGT + + S+GN + SD++ +G GF+ + A + +
Sbjct: 97 HA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNER-----G 150
Query: 1975 PGACGGFLRTGDAPVFLF-SPGWPD-SYSNRVDCTWLIQAP-DSTVELNILSLDIESHRT 2031
CGG L D P F +P WPD Y V C W I AP + +EL D+E
Sbjct: 151 DQYCGGLL---DRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNY 207
Query: 2032 CAYDSL-VIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK 2090
C YD + V G+ N A+++ CG P PI S + I+F SD S+T GF
Sbjct: 208 CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF------ 261
Query: 2091 SCGGYLHADRGIITSPKYPET 2111
G Y+ + + T+ + P T
Sbjct: 262 -IGHYIFRPKKLPTTTEQPVT 281
Score = 110 bits (274), Expect = 3e-23
Identities = 67/242 (27%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRF-DI 2269
E CGG + +G++ S P YPP++ C W + P + L F RF D+
Sbjct: 27 ERPVFTCGGIL----TGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNF--RFIDL 80
Query: 2270 EVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKA 2329
E C +++++ +G ++ + +FCGT P + SSG M ++ SD + GF A
Sbjct: 81 ESDNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMA 139
Query: 2330 KYSIAQ--------CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFED 2381
+S A+ CGG + SG ++ P Y + C WH+ + + FE
Sbjct: 140 MFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEK 199
Query: 2382 FNLQNSSGCEKDFVEIWDNH--TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTAS 2439
F+++ + C D+V +++ +G+YCG++ P I + N +++F++D S+TA
Sbjct: 200 FDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTAD 259
Query: 2440 GF 2441
GF
Sbjct: 260 GF 261
Score = 110 bits (274), Expect = 3e-23
Identities = 75/242 (30%), Positives = 117/242 (48%), Gaps = 14/242 (5%)
Query: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
CGG L G G S +P P C W+IT PEG+ + L F + L + C + V
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSE----- 2566
V+NG +N ++ + C + + SSGN M V +D + GF A ++++E
Sbjct: 93 VYNG-HANGQRIGRFCGTFR-PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
Query: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626
D CGG L + P G+F +P + R+Y + C W + P N I + FE F +E
Sbjct: 151 DQYCGGLL-DRPSGSFKTPNWPD-RDYPAGVTCVWHIVAPK--NQLIELKFEKFDVERDN 206
Query: 2627 DCQFD-VLEFRVGDA-DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
C++D V F G+ D + + CG S P P+V +++ I F+++ + GF Y
Sbjct: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPA-PIVSERNELLIQFLSDLSLTADGFIGHY 265
Query: 2685 SF 2686
F
Sbjct: 266 IF 267
Score = 109 bits (273), Expect = 4e-23
Identities = 78/236 (33%), Positives = 116/236 (49%), Gaps = 18/236 (7%)
Query: 2570 CGGSLPNTPEGNFT-SPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDC 2628
CGG L T E F S G+ GV Y N C W ++ P + ++F LES C
Sbjct: 33 CGGIL--TGESGFIGSEGFPGV--YPPNSKCTWKITVPE--GKVVVLNFRFIDLESDNLC 86
Query: 2629 QFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD 2688
++D ++ G A+G + R CG +P LV +++ + +++ GF A +S +
Sbjct: 87 RYDFVDVYNGHANGQRIGRFCGTFRPG-ALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
Query: 2689 --------CGGIQIGDSGVITSPNYPNA-YDSLTHCSSLLEAPQGHTITLTFSDFDIEPH 2739
CGG+ SG +PN+P+ Y + C + AP+ I L F FD+E
Sbjct: 146 PNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERD 205
Query: 2740 TTCAWDSVTVRNGGS-PESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF 2794
C +D V V NGG ++ IG+YCG+S P I S N+L++ F SD SL GF
Sbjct: 206 NYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
Score = 109 bits (272), Expect = 6e-23
Identities = 79/272 (29%), Positives = 121/272 (44%), Gaps = 23/272 (8%)
Query: 2882 GCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYD 2941
G AP ++ + T + QS E P V CG TG SG+I S +P Y
Sbjct: 3 GANAWAPLCLLLAAATQLSRQQSPERP--------VFTCGGILTGESGFIGSEGFPGVYP 54
Query: 2942 NNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGD 3001
N CT+ I VV+L F LE+ + C D V + G++ CG
Sbjct: 55 PNSKCTWKITVPEGKVVVLNFRFIDLESDNL----CRYDFVDVYNGHA-NGQRIGRFCGT 109
Query: 3002 EMPAPLTIAG-PVLLNFYSNEQITDFGFKFSYRIIS--------CGGVFNFSSGIITSPA 3052
P L +G +++ S+ GF + CGG+ + SG +P
Sbjct: 110 FRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPN 169
Query: 3053 YSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDP-LLGK 3111
+ DYP + C++ I +++IELKF FDV C +DY+A+++G +D +GK
Sbjct: 170 WPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGK 229
Query: 3112 FCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGW 3143
+CG P + S N +L+ F +D TA G+
Sbjct: 230 YCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
Score = 105 bits (261), Expect = 1e-21
Identities = 68/230 (29%), Positives = 110/230 (47%), Gaps = 10/230 (4%)
Query: 1053 TDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDG 1112
T + G S FP YP N +C ++ITV G+++ ++F LE Y DF+++ +G
Sbjct: 38 TGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY-DFVDVYNG 96
Query: 1113 GYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG------CG 1166
+ +G F G+ P ++S NK+ ++ SD +GF A + + CG
Sbjct: 97 -HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCG 155
Query: 1167 GNLTTSSGTFISPNYP-MPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAV 1225
G L SG+F +PN+P Y C W + + EL+F+ F +E C DY+AV
Sbjct: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
Query: 1226 YDGPSSN-SHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
++G N + + + CGD P I S + + I+ +D GF Y
Sbjct: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 97.8 bits (242), Expect = 2e-19
Identities = 67/243 (27%), Positives = 107/243 (44%), Gaps = 16/243 (6%)
Query: 586 QQPE-----CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHH 640
Q PE CGGILTG G I S G+PG YPP C W + +V F + LE
Sbjct: 24 QSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESD 83
Query: 641 DDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYL 700
+ C D++++ +G +G+FC TF L ++G + SD+ + GF +
Sbjct: 84 NLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFS 142
Query: 701 TSP----SDLRCGGNYTDPEGELFLPEL-SGPFTHTRQCVYMMKQPQGEQIQINFTHVEL 755
+ D CGG P G P + CV+ + P+ + I++ F ++
Sbjct: 143 AAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDV 202
Query: 756 QCQSDSSQNYIEVRDGETL-----LGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFR 810
+ + +Y+ V +G + +GK CG+ + I S N + I+F D S+ F
Sbjct: 203 ERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
Query: 811 AVY 813
Y
Sbjct: 263 GHY 265
Score = 96.7 bits (239), Expect = 4e-19
Identities = 65/222 (29%), Positives = 100/222 (45%), Gaps = 14/222 (6%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CGG LT SG S +P Y +S+C W + G L F+ LE C D++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
VY+G +N + + CG +P + SSG+ M +++ +D G GF A + N
Sbjct: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 1285 NQTYGILE----SIGYPN----PYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTD 1336
G+L+ S PN Y C W I A + F FD+E C D
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Query: 1337 YLELYDG-----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTD 1373
Y+ +++G R++G+YCG P P + ++L + L+D
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSD 253
Score = 91.7 bits (226), Expect = 1e-17
Identities = 64/213 (30%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
CGG LTG + S G+Y N C W I P KV+ L F LE+ + C
Sbjct: 33 CGGILTGESGFIGSEGFP--GVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL---CR 87
Query: 3217 YDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIM-- 3274
YD+V +Y+G + N G FCG+ P +SSGN + VQ ISD GF A ++
Sbjct: 88 YDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEP 146
Query: 3275 ----DMPCGGTYNATWTPQNISSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVWALQLTS 3329
D CGG + + +PN D D P + C W I +P +Q +++ +
Sbjct: 147 NERGDQYCGGLLDR--PSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVER 204
Query: 3330 QD-CTQNYLQLQDSPQGHGNSRF-QFCGRNASA 3360
+ C +Y+ + + + + R ++CG + A
Sbjct: 205 DNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
Score = 88.2 bits (217), Expect = 1e-16
Identities = 59/233 (25%), Positives = 105/233 (45%), Gaps = 15/233 (6%)
Query: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
CGG T G + G + +C + + P+G+ + +NF ++L+ + ++++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 768 VRDGET---LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVA----CGDE 820
V +G +G+ CG + S N + ++ DA+ F A++ A GD+
Sbjct: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
Query: 821 LTG------EGVIRSPFFPN-VYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDY 873
G G ++P +P+ YP TC W I P++Q+I L F F++ +C DY
Sbjct: 153 YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
Query: 874 VEI-GSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF 925
V + + + KYCG P+ I S N L + F+ S GF+ +
Sbjct: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 71.6 bits (174), Expect = 1e-11
Identities = 34/99 (34%), Positives = 57/99 (57%), Gaps = 2/99 (2%)
Query: 3511 CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLT 3570
CGG L G+ G S G+PG YP N+ C W + P G++V +NF FI ++ C +++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHAD 3609
+Y+G +A+ G +CG A V+S N++ ++ +D
Sbjct: 93 VYNG-HANGQRIGRFCGTFRPGA-LVSSGNKMMVQMISD 129
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 149 bits (375), Expect = 6e-35
Identities = 112/340 (32%), Positives = 158/340 (46%), Gaps = 46/340 (13%)
Query: 145 GTCLNLHDSFFCICPPQWKGPLC----SADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
GTC+N SF C C P ++ DV+EC + PL C+ GGTC NT GSY C
Sbjct: 1042 GTCVNTPGSFECECFPGYESGFMLMKNCMDVDEC---ARDPLLCR-GGTCTNTDGSYKCQ 1097
Query: 201 CPPETYGPQCASKYDDCE-----GGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSP 255
CPP G + +K CE S C HG C +++ + C C AG+ +P
Sbjct: 1098 CPP---GHELTAKGTACEDIDECSLSDGLCPHGQCVNVI------GAFQCSCHAGFQSTP 1148
Query: 256 NSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECEINN 313
+ C +D +EC Q G C V C NT+GS+ C +C G+ +G C D++ECE N
Sbjct: 1149 DRQGC-VDINECRVQNGGCD--VHCINTEGSYRC-SCGQGYSLMPDGRACADVDECEENP 1204
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQG--DGRVCTLTDICSVSNGGC-HPDASCSSTL 370
C C N PG C C G+ D R C D C ++ C H D C +T
Sbjct: 1205 RVCDQG---HCTNMPGGHRC-LCYDGFMATPDMRTCVDVDECDLNPHICLHGD--CENTK 1258
Query: 371 GSLPLCTCLPGYTGNGYGPNGCVQLSNICL-SHPC-LNGQCIDTVSGYFCKCDSGWT--G 426
GS +C C GY G GC + + H C + C++ + C+C GW G
Sbjct: 1259 GSF-VCHCQLGYMVR-KGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDG 1316
Query: 427 VNCTENINECLS--NPCLNGGTCVDGVDSFSCECTRLWTG 464
C +++EC+S + C G C++ S+ C C + + G
Sbjct: 1317 FEC-HDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAG 1355
Score = 148 bits (373), Expect = 1e-34
Identities = 120/394 (30%), Positives = 168/394 (42%), Gaps = 79/394 (20%)
Query: 121 ERKFQGLQQTVDKKVCSSNPCQ-NGGTCLNLHDSFFCICPP----QWKGPLCSADVNECE 175
E F ++ +D C+ +P GGTC N S+ C CPP KG C D++EC
Sbjct: 1060 ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECS 1118
Query: 176 IYSGT-------------PLSC---------------------QNGGT---CVNTMGSYS 198
+ G SC QNGG C+NT GSY
Sbjct: 1119 LSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYR 1178
Query: 199 CHC------PPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWM 252
C C P+ G CA D+CE C G C ++ + C+C G+M
Sbjct: 1179 CSCGQGYSLMPD--GRACAD-VDECEENPRV-CDQGHCTNM------PGGHRCLCYDGFM 1228
Query: 253 FSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECE 310
+P+ C +D DEC P C C NT+GSF C C G+ + C D++ECE
Sbjct: 1229 ATPDMRTC-VDVDECDLNPHIC-LHGDCENTKGSFVC-HCQLGYMVRKGATGCSDVDECE 1285
Query: 311 INNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTL 370
+ GG + C+N PGS C+ C PG+ GDG C D C C P C +
Sbjct: 1286 V--GGHNCDSHASCLNIPGSFSCR-CLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVP 1342
Query: 371 GSLPLCTCLPGYTGNGY---GPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGV 427
GS CTC G+ G+G+ + C + N+ L C NGQC++ GY C+C+ G+
Sbjct: 1343 GSY-RCTCRQGFAGDGFFCEDRDECAE--NVDL---CDNGQCLNAPGGYRCECEMGFDPT 1396
Query: 428 ---NCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
++++EC G+C + F C C
Sbjct: 1397 EDHRACQDVDECAQGNLCAFGSCENLPGMFRCIC 1430
Score = 133 bits (335), Expect = 3e-30
Identities = 116/405 (28%), Positives = 155/405 (38%), Gaps = 94/405 (23%)
Query: 131 VDKKVCSSNPCQ-NGGTCLNLHDSFFCICPPQWK-----GPLCSADVNECEIYSGTPLSC 184
VD+ C G C NL +F C+CPP + G C+ D NEC P C
Sbjct: 2208 VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECH---AQPDLC 2263
Query: 185 QNGGTCVNTMGSYSCHCPPETY-GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
N G CVNT GS+ C C P +D +G A + +C L +
Sbjct: 2264 VN-GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRA 2322
Query: 244 SCVCDAGWMFSPNSPACTL---------------------DRDEC--------------- 267
C C G + P C L D DEC
Sbjct: 2323 ECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINS 2382
Query: 268 --SFQ-------------------------PGPCSTLVQCFNTQGSFYCGACPTGW--QG 298
SF+ P PC+ L C NT+GSF C +CP G+ +
Sbjct: 2383 LGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFL--CKNTKGSFLC-SCPRGYLLEE 2439
Query: 299 NGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNG 358
+G C+D++EC C CVNT G+ C+ CPPG+ + C D CS G
Sbjct: 2440 DGRTCKDLDECTSRQHNCQFL----CVNTVGAFTCR-CPPGFTQHHQACFDNDECSAQPG 2494
Query: 359 GCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFC 418
C C +T GS C C G+T G +GC ++ H C +G C + + GY C
Sbjct: 2495 PCGAHGHCHNTPGSF-RCECHQGFTLVSSG-HGCEDVNECDGPHRCQHG-CQNQLGGYRC 2551
Query: 419 KCDSGWT----GVNCTENINEC-LSNPCLNGGTCVDGVDSFSCEC 458
C G+T C + NEC LS P +C + + F C C
Sbjct: 2552 SCPQGFTQHSQWAQCVDE-NECALSPPTCGSASCRNTLGGFRCVC 2595
Score = 124 bits (311), Expect = 2e-27
Identities = 118/391 (30%), Positives = 161/391 (41%), Gaps = 81/391 (20%)
Query: 132 DKKVCSSNP--CQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQ 185
D C+ +P C NG C NL S+ C+C ++ G C+ DV+EC + S L C
Sbjct: 682 DINECALDPEVCANG-VCENLRGSYRCVCNLGYEAGASGKDCT-DVDECALNS---LLCD 736
Query: 186 NGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSC 245
NG C N+ GSYSC CPP + Q D + + CV G+C +L AG Y+C
Sbjct: 737 NGW-CQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNL----AGS--YTC 789
Query: 246 VCDAGWMFSPNSPACT----------LDRDECSFQPGPCSTLVQCFNTQGSFYCGAC--- 292
C G P+ C + C S +C T G+ + C
Sbjct: 790 KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERC 849
Query: 293 ---PTGWQG----NGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD-- 343
P +G G C+D+NECE G C P CVNT GS C+ CP G D
Sbjct: 850 EIDPACARGFARMTGVTCDDVNECESFPGVC---PNGRCVNTAGSFRCE-CPEGLMLDAS 905
Query: 344 GRVCTLT-----------DICSVSNGGCHPDASCSSTLGSL-----------------PL 375
GR+C D C V+ G + C ++G++ L
Sbjct: 906 GRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASL 965
Query: 376 CTCLPGYTGNGY-GPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGWT----GVN 428
C G+ + + N C P C +G C +TV + C C G+ N
Sbjct: 966 CPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERN 1025
Query: 429 CTENINECLSNPCLNG-GTCVDGVDSFSCEC 458
CT+ I+EC +P L G GTCV+ SF CEC
Sbjct: 1026 CTD-IDECRISPDLCGQGTCVNTPGSFECEC 1055
Score = 122 bits (305), Expect = 8e-27
Identities = 108/371 (29%), Positives = 157/371 (42%), Gaps = 66/371 (17%)
Query: 129 QTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGP---LCSADVNECEIYSGTPLSCQ 185
+ +D C+S+PC +G C+N+ ++ C C P ++ DV+EC + G C
Sbjct: 446 ECIDVDECTSSPCHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL---CH 501
Query: 186 NGGTCVNTMGSYSCHCPPE-TYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYS 244
G CVNT GS+ C C P + D E + CV+G+C + + +S
Sbjct: 502 LG-RCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLN------EDGSFS 554
Query: 245 CVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYC---GACPTGWQGNGY 301
C+C G++ +P C +D DEC PG C C NT+GSF C G G G
Sbjct: 555 CLCKPGFLLAPGGHYC-MDIDECQ-TPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGR-- 609
Query: 302 ICEDIN---EC--EINNGGCS------VAPPVECVNTPGSSH---CQACPP--------- 338
+C D + C I G C+ V C P CQ CP
Sbjct: 610 VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQAL 669
Query: 339 -----GYQGDGRVCTLTDI--CSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNG 391
G DGR DI C++ C + C + GS C C GY G +
Sbjct: 670 CSSGLGITTDGR-----DINECALDPEVC-ANGVCENLRGSYR-CVCNLGYEAGASGKD- 721
Query: 392 CVQLSNICL-SHPCLNGQCIDTVSGYFCKCDSG---WTGVNCTENINECLSNPCLNGGTC 447
C + L S C NG C ++ Y C C G W ++++ECLS+PC++ G C
Sbjct: 722 CTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVC 780
Query: 448 VDGVDSFSCEC 458
+ S++C+C
Sbjct: 781 RNLAGSYTCKC 791
Score = 120 bits (302), Expect = 2e-26
Identities = 128/439 (29%), Positives = 175/439 (39%), Gaps = 107/439 (24%)
Query: 126 GLQQTVDKKVCSS-NPCQNG-----GTCLNLHDSFFCICPPQWK----GPLCSADVNECE 175
G T D + C + C G G+C NL F CIC ++ G C+ D+NEC
Sbjct: 1392 GFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCT-DINEC- 1449
Query: 176 IYSGTPLSCQNGGTCVNTMGSYSCHCPPE------------TYGPQCASKYDDCEGGSVA 223
P++C NG C+NT GSY C CP + T C + D G S
Sbjct: 1450 ---ADPVNCING-VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD-RGDSGI 1504
Query: 224 RCVHGI---------CEDLMRE---------QAGEPKYSCVCDAGWMFSPNSPACTL-DR 264
C I C L R A +Y +C G F PN L D
Sbjct: 1505 SCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDI 1564
Query: 265 DECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGY--ICEDINECEINNGGCSVAPPV 322
DEC PG C C NT GSF C CP G+ + + ICEDI+EC ++G C P
Sbjct: 1565 DECQELPGLCQG-GDCVNTFGSFQC-ECPPGYHLSEHTRICEDIDECSTHSGICG---PG 1619
Query: 323 ECVNTPGSSHCQACPPGYQ----GDGRVCTLTDICSVS-NGGCHPDAS---------CSS 368
C NT G+ C CP Y G+ + +C NG C + + CS
Sbjct: 1620 TCYNTLGNYTC-VCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSY 1678
Query: 369 TLGSL---PLCTC---------------LPGY-----TGNGYGPNGCVQLSNICLSHPCL 405
+G P C PG+ TG + C ++ IC
Sbjct: 1679 NIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICA----- 1733
Query: 406 NGQCIDTVSGYFCKCDSGWTGVN---CTENINECLS--NPCLNGGTCVDGVDSFSCECTR 460
NG CI+ + + C+C +G+ + E+++EC S +PC C++ S+ C+CTR
Sbjct: 1734 NGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTR 1793
Query: 461 ---LWTGALCQVPQQVCGE 476
L G C V + C E
Sbjct: 1794 GYKLSPGGAC-VGRNECRE 1811
Score = 120 bits (302), Expect = 2e-26
Identities = 121/396 (30%), Positives = 165/396 (41%), Gaps = 75/396 (18%)
Query: 125 QGLQQTVDKKVCSS------NPCQNGGTCLNLHDSFFCICPPQW----KGPLCSADVNEC 174
+G Q + D+ +C PC NG TC N+ S+ C+C P + G D +EC
Sbjct: 1834 RGFQASADQTLCMDIDECDRQPCGNG-TCKNIIGSYNCLCFPGFVVTHNGDC--VDFDEC 1890
Query: 175 EIYSGTPLSCQNGGTCVNTMGSYSCHCPP----ETYGPQCASKYDDCEGGSVA-RCVHGI 229
G G C+NT GS+ C C G C D E S+A C+ G
Sbjct: 1891 TTLVGQVCRF---GHCLNTAGSFHCLCQDGFELTADGKNCV---DTNECLSLAGTCLPGT 1944
Query: 230 CEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYC 289
C++L E + C+C G F S C +D DECS +P C C N+ GSF C
Sbjct: 1945 CQNL------EGSFRCICPPG--FQVQSDHC-IDIDECSEEPNLC-LFGTCTNSPGSFQC 1994
Query: 290 GACPTGW--QGNGYICEDINEC----EINNGGCSVAPPVE-------CVNTPGSSH---C 333
CP G+ NG+ C D + G CSV C PG C
Sbjct: 1995 -LCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC 2053
Query: 334 QACPP----GYQ-----GDGRVCTLTDI------CSVSNGGCHPDASCSSTLGSLPLCTC 378
+ CP +Q G G V D C+ + G C + C +T GS C C
Sbjct: 2054 ELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC-TNGVCVNTDGSFR-CEC 2111
Query: 379 LPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW-TGVNCT-ENINEC 436
GY+ + G N CV + HPC G C + + G+ C C G+ G+ T E+I+EC
Sbjct: 2112 PFGYSLDFTGIN-CVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDEC 2170
Query: 437 LSNPCLNGGTCVDGVDSFSCECTRLWT----GALCQ 468
NP L C + S+ C C +T GA+C+
Sbjct: 2171 SLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR 2206
Score = 116 bits (290), Expect = 5e-25
Identities = 105/372 (28%), Positives = 148/372 (39%), Gaps = 64/372 (17%)
Query: 129 QTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGTPLSCQ 185
+ VD+ +PCQ C+N+ S+ C C +K G C NEC P C
Sbjct: 1762 EDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VGRNECR---EIPNVCS 1817
Query: 186 NGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSC 245
+ G C++T GSY C C + D + C +G C++++ Y+C
Sbjct: 1818 H-GDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNII------GSYNC 1870
Query: 246 VCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GNGYIC 303
+C G++ + N +D DEC+ G C NT GSF+C C G++ +G C
Sbjct: 1871 LCFPGFVVTHNGDC--VDFDECTTLVGQVCRFGHCLNTAGSFHC-LCQDGFELTADGKNC 1927
Query: 304 EDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPD 363
D NEC G C P C N GS C CPPG+Q C D CS C
Sbjct: 1928 VDTNECLSLAGTCL---PGTCQNLEGSFRC-ICPPGFQVQSDHCIDIDECSEEPNLC-LF 1982
Query: 364 ASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSH----PCLNGQCIDTVSGYFC- 418
+C+++ GS C C PG+ + G + C + C + +T C
Sbjct: 1983 GTCTNSPGSFQ-CLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCC 2041
Query: 419 --KCDSGWTGVNC----------------------------TENINECLSNP--CLNGGT 446
+ GW G C E++NEC NP C N G
Sbjct: 2042 SKRPGEGW-GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTN-GV 2099
Query: 447 CVDGVDSFSCEC 458
CV+ SF CEC
Sbjct: 2100 CVNTDGSFRCEC 2111
Score = 114 bits (285), Expect = 2e-24
Identities = 103/330 (31%), Positives = 142/330 (43%), Gaps = 58/330 (17%)
Query: 170 DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPP----ETYGPQCAS--------KYDDC 217
DVNECE + G C NG CVNT GS+ C CP + G C ++D+
Sbjct: 869 DVNECESFPGV---CPNG-RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDED 924
Query: 218 EGG---------SVARCVHGICEDLMREQAGEP---KYSCVCDAGWMFSP----NSPACT 261
E G V C G + E +P +++ +C G F+ +
Sbjct: 925 ECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFY 984
Query: 262 LDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECEINNGGCSVA 319
D +EC PG C T C NT GSF+C AC G+ C DI+EC I+ C
Sbjct: 985 KDVNECKVFPGLC-THGTCRNTVGSFHC-ACAGGFALDAQERNCTDIDECRISPDLCGQG 1042
Query: 320 PPVECVNTPGSSHCQACPPGYQGDGRV---CTLTDICSVSNGGCHPDASCSSTLGSLPLC 376
CVNTPGS C+ C PGY+ + C D C+ C +C++T GS C
Sbjct: 1043 ---TCVNTPGSFECE-CFPGYESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDGSYK-C 1096
Query: 377 TCLPGYTGNGYGPNGCVQLSNICLSHP-CLNGQCIDTVSGYFCKCDSGWTGV----NCTE 431
C PG+ G C + LS C +GQC++ + + C C +G+ C +
Sbjct: 1097 QCPPGHELTAKG-TACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVD 1155
Query: 432 NINECLSNPCLNGGT---CVDGVDSFSCEC 458
INEC NGG C++ S+ C C
Sbjct: 1156 -INECRVQ---NGGCDVHCINTEGSYRCSC 1181
Score = 113 bits (283), Expect = 3e-24
Identities = 118/425 (27%), Positives = 165/425 (38%), Gaps = 79/425 (18%)
Query: 132 DKKVCSSNP--CQNGGTCLNLHDSFFCICP----PQWKGPLCSADVNECEIYSGTPLSCQ 185
D C+ NP C NG C+N SF C CP + G C D +EC + G P
Sbjct: 2084 DVNECAENPGVCTNG-VCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSV--GHPCG-- 2137
Query: 186 NGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSC 245
GTC N +G + C C + + P +D + S+ +C R E Y C
Sbjct: 2138 -QGTCTNVIGGFECACA-DGFEPGLMMTCEDIDECSLNPL---LCA--FRCHNTEGSYLC 2190
Query: 246 VCDAGWMFSPNSPACTLDRDECSFQPGPCSTL-VQCFNTQGSFYCGACPTGWQ---GNGY 301
C AG+ + C D DEC+ C ++C N G+F C CP G + G+G
Sbjct: 2191 TCPAGYTLREDGAMCR-DVDECADGQQDCHARGMECKNLIGTFAC-VCPPGMRPLPGSGE 2248
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCH 361
C D NEC C CVNT GS C C G+Q TLT+ + G C
Sbjct: 2249 GCTDDNECHAQPDLCVNG---RCVNTAGSFRCD-CDEGFQPSP---TLTECHDIRQGPCF 2301
Query: 362 PDA------SCSSTLGSLPLCTCLPGYTGNGYGPN-------GCVQLSNIC--------- 399
+ S SS+ ++ C G G G+GP G +C
Sbjct: 2302 AEVLQTMCRSLSSSSEAVTRAECCCG-GGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAE 2360
Query: 400 ---------LSHPCLNGQCIDTVSGYFCKCDSGW----TGVNCTENINECLSNPCLNGGT 446
L+H C +G+CI+++ + C C +G+ T C + ++EC P
Sbjct: 2361 GRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD-MDECSQVPKPCTFL 2419
Query: 447 CVDGVDSFSCECTRLW----TGALCQ------VPQQVCGESLSGINGSFSYRSPDVGYVH 496
C + SF C C R + G C+ Q C G+F+ R P H
Sbjct: 2420 CKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH 2479
Query: 497 DVNCF 501
CF
Sbjct: 2480 HQACF 2484
Score = 110 bits (276), Expect = 2e-23
Identities = 112/385 (29%), Positives = 153/385 (39%), Gaps = 90/385 (23%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSA-DVNECEIYSGTPLSCQNGGT 189
VD+ + C + +CLN+ SF C C P W G D++EC C G
Sbjct: 1281 VDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDEC---VSQEHRCSPRGD 1337
Query: 190 CVNTMGSYSCHCPPETYG--------PQCASKYDDCEGGSVARCVHGICEDLMREQAGEP 241
C+N GSY C C G +CA D C+ G G
Sbjct: 1338 CLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGG------------- 1384
Query: 242 KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GN 299
Y C C+ G+ + + AC D DEC+ G C N G F C C G++
Sbjct: 1385 -YRCECEMGFDPTEDHRACQ-DVDECA--QGNLCAFGSCENLPGMFRC-ICNGGYELDRG 1439
Query: 300 GYICEDINECEINNGGCSVAPPVE-----CVNTPGSSHCQACPPGYQ----GDGRVCTLT 350
G C DINEC A PV C+NTPGS C +CP ++ G G V T
Sbjct: 1440 GGNCTDINEC---------ADPVNCINGVCINTPGSYLC-SCPQDFELNPSGVGCVDTRA 1489
Query: 351 DICSV-------SNGGCHPD-------ASCSSTLG-----SLPLC---------TCLPGY 382
C + S C + ASC +LG LC T PG
Sbjct: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPG- 1548
Query: 383 TGNGYGPNG-CVQLSNI--CLSHP--CLNGQCIDTVSGYFCKCDSGW---TGVNCTENIN 434
G G+ PN V L +I C P C G C++T + C+C G+ E+I+
Sbjct: 1549 -GEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
Query: 435 ECLSNPCLNG-GTCVDGVDSFSCEC 458
EC ++ + G GTC + + +++C C
Sbjct: 1608 ECSTHSGICGPGTCYNTLGNYTCVC 1632
Score = 106 bits (265), Expect = 4e-22
Identities = 97/332 (29%), Positives = 134/332 (40%), Gaps = 65/332 (19%)
Query: 170 DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETY---GPQCASKYDDCEGGSVARCV 226
D++EC+ G CQ GG CVNT GS+ C CPP + + D+C S C
Sbjct: 1563 DIDECQELPGL---CQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHS-GICG 1617
Query: 227 HGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQ--PGPCST-------- 276
G C + + Y+CVC A ++ C R F+ G C
Sbjct: 1618 PGTCYNTL------GNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTR 1671
Query: 277 -LVQCFNTQGSFY---CGACPT----------GWQGNGYICE-------DINECEINNGG 315
+ C G + C ACPT G Q G++ + DI+EC
Sbjct: 1672 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAI 1731
Query: 316 CSVAPPVECVNTPGSSHCQACPPGYQGDG--RVCTLTDICSVSNGGCHPDASCSSTLGSL 373
C+ C+N GS C+ CP G+ + C D C C +A C + GS
Sbjct: 1732 CANG---ICINQIGSFRCE-CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSY 1787
Query: 374 PLCTCLPGYT----GNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW---TG 426
C C GY G G N C ++ N+C SH G C+DT Y C C G+
Sbjct: 1788 -RCKCTRGYKLSPGGACVGRNECREIPNVC-SH----GDCMDTEGSYMCLCHRGFQASAD 1841
Query: 427 VNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
+I+EC PC N GTC + + S++C C
Sbjct: 1842 QTLCMDIDECDRQPCGN-GTCKNIIGSYNCLC 1872
Score = 106 bits (264), Expect = 5e-22
Identities = 93/292 (31%), Positives = 122/292 (41%), Gaps = 40/292 (13%)
Query: 145 GTCLNLHDSFFCICP----PQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
G C+N SF C C P C D++EC S P C C NT GS+ C
Sbjct: 2377 GECINSLGSFRCHCQAGYTPDATATTC-LDMDEC---SQVPKPCTF--LCKNTKGSFLCS 2430
Query: 201 CPP----ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPN 256
CP E G C D+C H C+ L G ++C C G F+ +
Sbjct: 2431 CPRGYLLEEDGRTCKD-LDECTSRQ-----HN-CQFLCVNTVGA--FTCRCPPG--FTQH 2479
Query: 257 SPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GNGYICEDINECEINNG 314
AC D DECS QPGPC C NT GSF C C G+ +G+ CED+NEC+
Sbjct: 2480 HQAC-FDNDECSAQPGPCGAHGHCHNTPGSFRC-ECHQGFTLVSSGHGCEDVNECD-GPH 2536
Query: 315 GCSVAPPVECVNTPGSSHCQACPPGY--QGDGRVCTLTDICSVSNGGCHPDASCSSTLGS 372
C C N G C +CP G+ C + C++S C ASC +TLG
Sbjct: 2537 RCQHG----CQNQLGGYRC-SCPQGFTQHSQWAQCVDENECALSPPTC-GSASCRNTLGG 2590
Query: 373 LPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW 424
C C G+ + GC ++ + C +T G+ C C G+
Sbjct: 2591 F-RCVCPSGFDFD-QALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY 2640
Score = 92.8 bits (229), Expect = 5e-18
Identities = 94/328 (28%), Positives = 136/328 (41%), Gaps = 58/328 (17%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQN 186
VD+ + S C G C+N SF C+C ++ G C D NEC T C N
Sbjct: 490 VDECIVSGGLCHLG-RCVNTEGSFQCVCNAGFELSPDGKNC-VDHNEC----ATSTMCVN 543
Query: 187 GGTCVNTMGSYSCHCPPETY---GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
G C+N GS+SC C P G D+C+ + CV+G C + E +
Sbjct: 544 G-VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGI--CVNGHCTNT------EGSF 594
Query: 244 SCVCDAGWMFSPNSPAC--TLDRDEC--SFQPGPCS-----TLVQ----CFNTQGSFY-- 288
C C G + C T R C + + G C+ T+ + C N F
Sbjct: 595 RCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEP 654
Query: 289 CGACPTG---------WQGNGYICE--DINECEINNGGCSVAPPVECVNTPGSSHCQACP 337
C CP G G + DINEC ++ C+ C N GS C C
Sbjct: 655 CQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGV---CENLRGSYRC-VCN 710
Query: 338 PGYQG--DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQL 395
GY+ G+ CT D C++++ C + C ++ GS C+C PG+ + + +
Sbjct: 711 LGYEAGASGKDCTDVDECALNSLLCD-NGWCQNSPGSYS-CSCPPGF--HFWQDTEICKD 766
Query: 396 SNICLSHPCLNGQCIDTVSGYFCKCDSG 423
+ CLS PC++G C + Y CKC G
Sbjct: 767 VDECLSSPCVSGVCRNLAGSYTCKCGPG 794
Score = 90.1 bits (222), Expect = 4e-17
Identities = 98/375 (26%), Positives = 142/375 (37%), Gaps = 81/375 (21%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
C NGGTC C+C + G +C + C+ C NGG C+ G C
Sbjct: 124 CMNGGTCRGAS----CLCQKGYTGTVCGQPI--CD------RGCHNGGRCI---GPNRCA 168
Query: 201 CPPETYGPQCASKY-----------DDCEGGSVAR-CVHGICEDLMREQAGEPKYSC--- 245
C GPQC Y + C+ C +C + G P C
Sbjct: 169 CVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQ 228
Query: 246 --VCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GNGY 301
C G++ + ++ AC D DEC PG C C N GSF+C CP G + +
Sbjct: 229 PHPCRRGFIPNIHTGACQ-DVDECQAVPGLCQG-GSCVNMVGSFHC-RCPVGHRLSDSSA 285
Query: 302 ICEDI------------------------NECEINNGGCSVAPPVECVNTPGSSH----- 332
CED +C + G C A PV + P S+
Sbjct: 286 ACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQL 345
Query: 333 -CQACP--PGYQGDGRVCTLTDICSVSNGGCHPDASCS--STLGSLPLCTCLPGYTGNGY 387
Q P PG+ G + + G P + + GS G +
Sbjct: 346 CAQRLPLLPGHPG-----LFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNI 400
Query: 388 GPNGCVQLSNIC--LSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTE--NINECLSNPCLN 443
G Q +IC ++ CLNG+C+ T S Y C+C+ G+T E +++EC S+PC +
Sbjct: 401 GTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPC-H 459
Query: 444 GGTCVDGVDSFSCEC 458
G CV+ ++ C C
Sbjct: 460 HGDCVNIPGTYHCRC 474
Score = 89.0 bits (219), Expect = 8e-17
Identities = 103/374 (27%), Positives = 146/374 (39%), Gaps = 59/374 (15%)
Query: 126 GLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIY-SGTPLSC 184
G Q VD+ CQ GG+C+N+ SF C CP G S CE Y +G S
Sbjct: 243 GACQDVDECQAVPGLCQ-GGSCVNMVGSFHCRCP---VGHRLSDSSAACEDYRAGACFSV 298
Query: 185 QNGGTCVNTMGSY----SCHCP----------PETYGPQ--------CASKYDDCEG--- 219
GG C + + C C PE P+ CA + G
Sbjct: 299 LFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPG 358
Query: 220 ---GSVARCVHGICEDL----MREQAGEPKYSCVCDAGWMFSPNSPACTLDR--DECSFQ 270
G + +G+ L + + + G + N TL++ D C
Sbjct: 359 LFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPG---NSNIGTATLNQTIDICRHF 415
Query: 271 PGPCSTLVQCFNTQGSFYCGACPTGW-QGNGYICEDINECEINNGGCSVAPPVECVNTPG 329
C +C T S+ C C G+ Q C D++EC S +CVN PG
Sbjct: 416 TNLCLN-GRCLPTPSSYRC-ECNVGYTQDVRGECIDVDECT-----SSPCHHGDCVNIPG 468
Query: 330 SSHCQACPPGYQG--DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGY 387
+ HC+ C PG+Q + C D C VS G CH C +T GS C C G+ +
Sbjct: 469 TYHCR-CYPGFQATPTRQACVDVDECIVSGGLCHL-GRCVNTEGSFQ-CVCNAGFELSPD 525
Query: 388 GPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW---TGVNCTENINECLSNPCLNG 444
G N CV + S C+NG C++ + C C G+ G + +I+EC +
Sbjct: 526 GKN-CVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN 584
Query: 445 GTCVDGVDSFSCEC 458
G C + SF C+C
Sbjct: 585 GHCTNTEGSFRCQC 598
Score = 45.1 bits (105), Expect = 0.001
Identities = 46/162 (28%), Positives = 61/162 (37%), Gaps = 35/162 (21%)
Query: 332 HCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN- 390
H CP GR + IC + G + CS LCTC G G +
Sbjct: 65 HAYCCPGWRTFPGRSQCVVPICRRACG----EGFCSQP----NLCTCADGTLAPSCGVSR 116
Query: 391 --GCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCV 448
GC S C+NG T G C C G+TG C + I C NGG C+
Sbjct: 117 GSGC--------SVSCMNG---GTCRGASCLCQKGYTGTVCGQPI---CDRGCHNGGRCI 162
Query: 449 DGVDSFSC-------ECTRLWTGALC--QVPQQVCGESLSGI 481
G + +C +C R + C QV + C L+G+
Sbjct: 163 -GPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGL 203
Score = 37.7 bits (86), Expect = 0.21
Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 3/75 (4%)
Query: 129 QTVDKKVCSSNPCQNGG-TCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNG 187
Q VD+ C+ +P G +C N F C+CP + E + +G C
Sbjct: 2565 QCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSY- 2623
Query: 188 GTCVNTMGSYSCHCP 202
+C NT G + C CP
Sbjct: 2624 -SCANTPGGFLCGCP 2637
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 148 bits (374), Expect = 8e-35
Identities = 80/242 (33%), Positives = 130/242 (53%), Gaps = 11/242 (4%)
Query: 817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVE 875
CG ++ GE G + S FPN+YP + C WTI P+ Q + L+F VF++ C D +E
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 876 IGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFS------AED 929
+ + S ++CGT P+ + + N + + T GF+ +S E
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 930 LACGEILTESTGTIQSPGHP-NVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTND 988
CG L ++ GT+ +P P + YP GI+C+WHI+ P+ +I L FE F LE C D
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
Query: 989 YLEVYD---TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAA 1045
+ V++ +D LG++CG ++P S++S GN L++ FV+D + +GF +Y+ +
Sbjct: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
Query: 1046 TA 1047
TA
Sbjct: 277 TA 278
Score = 147 bits (370), Expect = 2e-34
Identities = 87/242 (35%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Query: 3034 IISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSH 3093
+ CGG SG + S + YP + C++TITV + + + L F FD+ +C +
Sbjct: 34 VFLCGGDVKGESGYVASEGFPNL-YPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
Query: 3094 DYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKM--SFRQTL 3151
D L ++ G+ TS LG+FCG+ RP + + N + L TD +G+ + S R T
Sbjct: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
Query: 3152 GPQ-QGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAS 3210
G + Q CGG L + T +P+ + Y ++C W IIAP ++VI LTF F LE +
Sbjct: 153 GTEHQFCGGRLEKAQGTLTTPNWPESD-YPPGISCSWHIIAPPDQVIALTFEKFDLEPDT 211
Query: 3211 TRQRCLYDYVKLYDGD-SENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269
C YD V +++G S+++ G FCG VP S GN L VQF+SDL++ +GF+A
Sbjct: 212 ---YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSA 268
Query: 3270 TY 3271
+Y
Sbjct: 269 SY 270
Score = 146 bits (369), Expect = 3e-34
Identities = 85/242 (35%), Positives = 123/242 (50%), Gaps = 16/242 (6%)
Query: 1388 VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFD 1447
V+ CGG++ G +G +S GFPN YPPNKECIW I G ++ L+ FD+E H C +D
Sbjct: 34 VFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYD 93
Query: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNA--SWQA 1505
LE++ G R+ + C P + + GN++ +R TD GRGF S +A
Sbjct: 94 ALEVFAGSGTSGQRLGRFC---GTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
Query: 1506 VTGG----CGGIFQAPSGEIHSPNYP-SPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
+G CGG + G + +PN+P S Y CSW I + + L F FDLEP
Sbjct: 151 TSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPD 210
Query: 1561 DSC----IMAYDG-LSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQ 1615
C + ++G +S RL + CG + + I S GN L ++F S S GF A
Sbjct: 211 TYCRYDSVSVFNGAVSDDSRRLGKFCG-DAVPGSISSEGNELLVQFVSDLSVTADGFSAS 269
Query: 1616 FR 1617
++
Sbjct: 270 YK 271
Score = 136 bits (343), Expect = 3e-31
Identities = 82/246 (33%), Positives = 123/246 (50%), Gaps = 24/246 (9%)
Query: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP---- 1344
G + S G+PN Y N+ C WTI G TV+ +F FDLE H C D LE++ G
Sbjct: 46 GYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSG 105
Query: 1345 RQMGRYCGVDLPPPGSTTSSKLQVLLLTDG-----------VGRREKGFQMQWFVYGCGG 1393
+++GR+CG P P +++ + + TD GR G + Q+ CGG
Sbjct: 106 QRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQF----CGG 161
Query: 1394 ELSGATGSFSSPGFPNR-YPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIY 1452
L A G+ ++P +P YPP C W+I P I LT FD+E + C +D + ++
Sbjct: 162 RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVF 221
Query: 1453 GGP-DFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCG 1511
G S R+ + C P + +SS GNEL ++F +DLS+ GF+AS++ + G
Sbjct: 222 NGAVSDDSRRLGKFCGDAVPGS---ISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278
Query: 1512 GIFQAP 1517
Q P
Sbjct: 279 KEGQGP 284
Score = 135 bits (339), Expect = 1e-30
Identities = 79/254 (31%), Positives = 122/254 (48%), Gaps = 15/254 (5%)
Query: 2204 QGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQF 2263
QG Y CGG+V +GYV S P+ YPP+ +CIW + P + L F
Sbjct: 24 QGQTPNYTRPVFLCGGDV----KGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSF 79
Query: 2264 EDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
FD+E+ P C + LE+ G + L +FCGT P+ + G + LR +D
Sbjct: 80 RV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTG 138
Query: 2324 HVGFKAKYSIAQ--------CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYL 2375
GF YS CGGR+ G + + P Y + C WH+ +
Sbjct: 139 GRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVI 198
Query: 2376 TISFEDFNLQNSSGCEKDFVEIWDNHTSGNI--LGRYCGNTIPDSIDTSSNTAVVRFVTD 2433
++FE F+L+ + C D V +++ S + LG++CG+ +P SI + N +V+FV+D
Sbjct: 199 ALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
Query: 2434 GSVTASGFRLRFES 2447
SVTA GF +++
Sbjct: 259 LSVTADGFSASYKT 272
Score = 133 bits (335), Expect = 3e-30
Identities = 93/259 (35%), Positives = 130/259 (50%), Gaps = 18/259 (6%)
Query: 2557 GFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIH 2616
G T +YT +CGG + G S G+ + Y N C WT++ P ++S+
Sbjct: 25 GQTPNYTRPV-FLCGGDVKGE-SGYVASEGFPNL--YPPNKECIWTITVPE--GQTVSLS 78
Query: 2617 FEDFYLESHQDCQFDVLEFRVGDA-DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERV 2675
F F LE H C++D LE G G + R CG +P PLV P +QV + T+E
Sbjct: 79 FRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGT 137
Query: 2676 EHIGFHAKYS--------FTDCGGIQIGDSGVITSPNYPNA-YDSLTHCSSLLEAPQGHT 2726
GF YS CGG G +T+PN+P + Y CS + AP
Sbjct: 138 GGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQV 197
Query: 2727 ITLTFSDFDIEPHTTCAWDSVTVRNGG-SPESPIIGQYCGNSNPRTIQSGSNQLVVTFNS 2785
I LTF FD+EP T C +DSV+V NG S +S +G++CG++ P +I S N+L+V F S
Sbjct: 198 IALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVS 257
Query: 2786 DHSLQGGGFYATWNTQTLG 2804
D S+ GF A++ T G
Sbjct: 258 DLSVTADGFSASYKTLPRG 276
Score = 130 bits (326), Expect = 3e-29
Identities = 73/236 (30%), Positives = 111/236 (47%), Gaps = 10/236 (4%)
Query: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
CGG G+SG + S +PN Y C + P+G T++L+F FD+E H C +D++
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFY------ATWNTQT 2802
V G +G++CG P + + NQ+ + +D G GF AT T+
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 2803 LGCGGIFHSDNGTIRSPHWPQ-NFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQ 2861
CGG GT+ +P+WP+ ++P CSW I + + ++F+ L P D C+
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEP--DTYCR 214
Query: 2862 NSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASF 2916
V V+ G D L CG+ PG + + N F S A GFSAS+
Sbjct: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Score = 129 bits (325), Expect = 4e-29
Identities = 78/237 (32%), Positives = 116/237 (48%), Gaps = 12/237 (5%)
Query: 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDF 1679
CGG + S V+S FP YP N+ C W I P ++LSF F+LE C D
Sbjct: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITV-PEGQTVSLSFRVFDLELHPACRYDA 94
Query: 1680 VEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF------HTTVTA 1733
+E+ G GR+CGT P P+ + + +TLR +D GF T
Sbjct: 95 LEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGT 154
Query: 1734 SVSACGGTFYMAEGIFNSPGYPDI-YPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCS 1792
CGG A+G +P +P+ YPP + C W+I++ P + L+F F LE C
Sbjct: 155 EHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
Query: 1793 RDFVEIREGNAT--GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847
D V + G + +G++CG++ P + SS G+ L V+F+SD S + GF A++
Sbjct: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISS-EGNELLVQFVSDLSVTADGFSASY 270
Score = 125 bits (315), Expect = 6e-28
Identities = 78/238 (32%), Positives = 116/238 (48%), Gaps = 11/238 (4%)
Query: 1855 NIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYD 1914
++ G G VAS +P YP N WT+ V V D+E C YD L ++
Sbjct: 40 DVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFA 99
Query: 1915 GPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTI 1973
G + +G +CGT + + GN +T +D G+GFLL W++ A G
Sbjct: 100 GSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLL-WYSGRATSGTEHQF 158
Query: 1974 APGACGGFLRTGDAPVFLFSPGWPDS-YSNRVDCTW-LIQAPDSTVELNILSLDIESHRT 2031
CGG R A L +P WP+S Y + C+W +I PD + L D+E
Sbjct: 159 ----CGG--RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTY 212
Query: 2032 CAYDSLVIRDGD-NNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
C YDS+ + +G ++ +++L CG +PG I S G + ++F SD SVT GF+AS+
Sbjct: 213 CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270
Score = 124 bits (311), Expect = 2e-27
Identities = 82/253 (32%), Positives = 119/253 (47%), Gaps = 17/253 (6%)
Query: 2909 AQGFSASF---VSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSF 2965
AQG + ++ V CG + G SGY+ S +P Y N C + I V L+F F
Sbjct: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
Query: 2966 HLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNEQIT 3024
LE A C D + + G CG PAPL G V L ++E
Sbjct: 83 DLELHPA----CRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTG 138
Query: 3025 DFGFK--FSYRIIS------CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVI 3076
GF +S R S CGG + G +T+P + +DYP + C + I D+VI
Sbjct: 139 GRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVI 198
Query: 3077 ELKFSDFDVVPSTSCSHDYLAIYDGANTSDP-LLGKFCGSKRPPNVKSSNNSMLLVFKTD 3135
L F FD+ P T C +D +++++GA + D LGKFCG P ++ S N +L+ F +D
Sbjct: 199 ALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
Query: 3136 SFQTAKGWKMSFR 3148
TA G+ S++
Sbjct: 259 LSVTADGFSASYK 271
Score = 122 bits (305), Expect = 8e-27
Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 12/276 (4%)
Query: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529
P +CG + G +G + Y + C W I G+ + ++F F LE C +
Sbjct: 33 PVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
Query: 530 EFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWE----- 584
+ L+V+ G +S +LGRFCG+ P L++ N + + ++ GRGF + +
Sbjct: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
Query: 585 -TQQPECGGILTGPYGSIKSPGYP-GNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD 642
T+ CGG L G++ +P +P +YPPG C W ++ PD ++ TF LE
Sbjct: 153 GTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTY 212
Query: 643 CNKDYLEIRDGPLYQDP-LLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT 701
C D + + +G + D LGKFC + + G + F SD ++ GF +Y T
Sbjct: 213 CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKT 272
Query: 702 SPSDLRCGGNYTDP----EGELFLPELSGPFTHTRQ 733
P G P E ++ LP S P T +
Sbjct: 273 LPRGTAKEGQGPGPKRGTEPKVKLPPKSQPPEKTEE 308
Score = 121 bits (304), Expect = 1e-26
Identities = 74/245 (30%), Positives = 115/245 (46%), Gaps = 21/245 (8%)
Query: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDS-TVELNILSLDIESHRTCAYDS 2036
CGG ++ ++ S G+P+ Y +C W I P+ TV L+ D+E H C YD+
Sbjct: 37 CGGDVKGESG--YVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDA 94
Query: 2037 LVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGF---------NAS 2087
L + G Q+L CG P P+ + G + +R T+D GF + +
Sbjct: 95 LEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGT 154
Query: 2088 FHKSCGGYLHADRGIITSPKYPET-YPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSS 2146
H+ CGG L +G +T+P +PE+ YP ++CSWH++ IA+ FE+ F + D+
Sbjct: 155 EHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEK-FDL-EPDTY 212
Query: 2147 CNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGF 2206
C V S L G FCG ++ + N++ VQF+SD S GF
Sbjct: 213 CRYDSVSVFNGAVSDDSRRL------GKFCGDAVPGSISSEGNELLVQFVSDLSVTADGF 266
Query: 2207 KIKYE 2211
Y+
Sbjct: 267 SASYK 271
Score = 120 bits (301), Expect = 2e-26
Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 11/244 (4%)
Query: 3387 SFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSV 3446
++T + C D G + S G+P+ Y +K+C T+T P+ T+SL F +E
Sbjct: 29 NYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHP 88
Query: 3447 ECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTS 3506
CR D LEV GS ++ LG++CGT P P+ + N++ LR +D T RG+ ++W S
Sbjct: 89 ACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF-LLWYS 147
Query: 3507 --SPSG-----CGGTLYGDRGSFTSPGYP-GTYPNNTYCEWVLVAPAGRLVTINFYFISI 3558
+ SG CGG L +G+ T+P +P YP C W ++AP +++ + F +
Sbjct: 148 GRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDL 207
Query: 3559 DDPGDCVQNYLTLYDGP-NASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
+ C + +++++G + S G +C GD + N++ ++F +D + F
Sbjct: 208 EPDTYCRYDSVSVFNGAVSDDSRRLGKFC-GDAVPGSISSEGNELLVQFVSDLSVTADGF 266
Query: 3618 RLTW 3621
++
Sbjct: 267 SASY 270
Score = 117 bits (292), Expect = 3e-25
Identities = 81/260 (31%), Positives = 123/260 (47%), Gaps = 22/260 (8%)
Query: 2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGD 2151
CGG + + G + S +P YP N C W + V G T+++ F + F + +C D
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSF-RVFDLEL-HPACRY-D 93
Query: 2152 YLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYE 2211
L + G LG FCG+ + L NQ+ ++ +D G+GF + Y
Sbjct: 94 ALEVFAGSGTSGQRLG------RFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYS 147
Query: 2212 AKSLA------CGGNVYIHDADSAGYVTSPNHPHN-YPPHADCIWILAAPPETRIQLQFE 2264
++ + CGG + + G +T+PN P + YPP C W + APP+ I L FE
Sbjct: 148 GRATSGTEHQFCGGRL----EKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFE 203
Query: 2265 DRFDIEVTPNCTSNYLELRDG-VDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
+FD+E C + + + +G V D+ L KFCG ++P S S G + ++F SD S T
Sbjct: 204 -KFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVT 262
Query: 2324 HVGFKAKYSIAQCGGRVPGQ 2343
GF A Y G GQ
Sbjct: 263 ADGFSASYKTLPRGTAKEGQ 282
Score = 116 bits (291), Expect = 4e-25
Identities = 75/236 (31%), Positives = 111/236 (47%), Gaps = 9/236 (3%)
Query: 1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFL 1107
C D + G S FPN YP N ECI+ ITV GQ +++ F F LE Y D L
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY-DAL 95
Query: 1108 EIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG--- 1164
E+ G LG F G+ P +++ N++ L+ +D+ GF ++ G +T
Sbjct: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
Query: 1165 ---CGGNLTTSSGTFISPNYP-MPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTL 1220
CGG L + GT +PN+P Y C W + + L F+ F LE C
Sbjct: 156 HQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRY 215
Query: 1221 DYLAVYDGP-SSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
D ++V++G S +S L + CGD P I S G+ + ++ +D GF A Y+
Sbjct: 216 DSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
Score = 114 bits (286), Expect = 1e-24
Identities = 76/245 (31%), Positives = 110/245 (44%), Gaps = 13/245 (5%)
Query: 1724 AGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISF 1783
A G T V CGG G S G+P++YPPN EC+W I G + LSF F
Sbjct: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
Query: 1784 QLEDSQDCSRDFVEIREGNAT-GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG 1842
LE C D +E+ G+ T G +GR+CG P + G+ + +R +D G G
Sbjct: 83 DLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVA-PGNQVTLRMTTDEGTGGRG 141
Query: 1843 FQATFM--------KIFGNDNIVGTHGKVASPFWPE-NYPHNSNYQWTVNVNASHVVHGR 1893
F + F + G + +P WPE +YP + W + V+
Sbjct: 142 FLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALT 201
Query: 1894 ILEMDIEEIQNCYYDKLRIYDGP-SIHARLIGAYCGTQTE-SFSSTGNSLTFHFYSDSSI 1951
+ D+E C YD + +++G S +R +G +CG S SS GN L F SD S+
Sbjct: 202 FEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSV 261
Query: 1952 SGKGF 1956
+ GF
Sbjct: 262 TADGF 266
Score = 107 bits (266), Expect = 3e-22
Identities = 66/224 (29%), Positives = 105/224 (46%), Gaps = 17/224 (7%)
Query: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
CGG++ SG S +P Y + EC W + G L F+ F LE HP C D L
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY---------R 1275
V+ G ++ L + CG +P + + G+ + +++ TDEG GRGF Y
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 1276 QTCENVVIVNQTYGILESIGYP-NPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCS 1334
Q C + + G L + +P + Y C+W I A + TF FDLE C
Sbjct: 157 QFCGG--RLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCR 214
Query: 1335 TDYLELYDG-----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTD 1373
D + +++G R++G++CG +P S+ ++L V ++D
Sbjct: 215 YDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSD 258
Score = 102 bits (253), Expect = 9e-21
Identities = 69/235 (29%), Positives = 102/235 (43%), Gaps = 10/235 (4%)
Query: 590 CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLE 649
CGG + G G + S G+P YPP ++C+W + V+ +F LE H C D LE
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 650 IRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITY---LTSPSDL 706
+ G LG+FC TF PL G + +D +GF + Y TS ++
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 707 R-CGGNYTDPEGELFLPEL-SGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ----CQSD 760
+ CGG +G L P + C + + P + I + F +L+ C+ D
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
Query: 761 SSQNYI-EVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQ 814
S + V D LGK CG+ I S N + ++F D SV F A Y+
Sbjct: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
Score = 97.8 bits (242), Expect = 2e-19
Identities = 69/241 (28%), Positives = 113/241 (46%), Gaps = 15/241 (6%)
Query: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
CGGD++G G S +PN P + C W IT PEG+ ++L F L HP+C + +
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY-----TSSE 2566
VF G ++ +L + C + + + + GN + + TD GF Y + +E
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPA-PLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155
Query: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626
CGG L +G T+P + +Y ++C W + P + I++ FE F LE
Sbjct: 156 HQFCGGRLEKA-QGTLTTPNWP-ESDYPPGISCSWHIIAP--PDQVIALTFEKFDLEPDT 211
Query: 2627 DCQFD---VLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAK 2683
C++D V V D D + + CG + P + +++ + FV++ V GF A
Sbjct: 212 YCRYDSVSVFNGAVSD-DSRRLGKFCGDAVPG-SISSEGNELLVQFVSDLSVTADGFSAS 269
Query: 2684 Y 2684
Y
Sbjct: 270 Y 270
Score = 88.2 bits (217), Expect = 1e-16
Identities = 69/249 (27%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFD--NNFLIPSGDGQCQN 2862
CGG ++G + S +P +P N C WT + + + +SF + L P+ C+
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPA----CRY 92
Query: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPA-QGFSASFVSR-- 2919
++V+AG+ + L CG P P++ P N T + E +GF + R
Sbjct: 93 DALEVFAGSGTSGQRL-GRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRAT 151
Query: 2920 -------CGSNFTGPSGYIISPNYPKQ-YDNNMNCTYVIEANPLSVVLLTFVSFHLEARS 2971
CG G + +PN+P+ Y ++C++ I A P V+ LTF F LE +
Sbjct: 152 SGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT 211
Query: 2972 AVTGSCVNDGVHIIRG-YSVMSTPFATVCGDEMPAPLTIAG-PVLLNFYSNEQITDFGFK 3029
C D V + G S S CGD +P ++ G +L+ F S+ +T GF
Sbjct: 212 Y----CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
Query: 3030 FSYRIISCG 3038
SY+ + G
Sbjct: 268 ASYKTLPRG 276
Score = 83.6 bits (205), Expect = 3e-15
Identities = 73/262 (27%), Positives = 109/262 (41%), Gaps = 25/262 (9%)
Query: 3265 EGFNATYTIMDMPCGGT------YNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQV 3318
+G YT CGG Y A+ N+ PN C W I P Q V
Sbjct: 24 QGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKE--------CIWTITVPEGQTV 75
Query: 3319 KITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKS 3377
++ L C + L++ G +FCG A V + T +
Sbjct: 76 SLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDE 135
Query: 3378 GVVNRNSRMSFTYQIAD------CNRDYHKAFGNLRSPGWPDN-YDNDKDCTVTLTAPQN 3430
G R + ++ + C KA G L +P WP++ Y C+ + AP +
Sbjct: 136 GTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPD 195
Query: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSN-SPLLGKYCGTLLPNPVFSQNNELYLRF 3489
I+L F +E CR D + V NG+ S+ S LGK+CG +P + S+ NEL ++F
Sbjct: 196 QVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQF 255
Query: 3490 KSD-SVTSDRGYEIIWTSSPSG 3510
SD SVT+D G+ + + P G
Sbjct: 256 VSDLSVTAD-GFSASYKTLPRG 276
Score = 83.2 bits (204), Expect = 4e-15
Identities = 62/227 (27%), Positives = 99/227 (43%), Gaps = 19/227 (8%)
Query: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
CGG + G + AS + +Y N C+W I P + + L+F F LE C
Sbjct: 37 CGGDVKGESGYVASEGFPN--LYPPNKECIWTITVPEGQTVSLSFRVFDLEL---HPACR 91
Query: 3217 YDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGF------NAT 3270
YD ++++ G + G FCG+ PAP ++ GN +T++ +D GF AT
Sbjct: 92 YDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRAT 151
Query: 3271 YTIMDMPCGGTYNATWTPQNISSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVWALQLTS 3329
CGG +++PN + D P I C+W I +PP Q + +T L
Sbjct: 152 SGTEHQFCGGRLEK--AQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEP 209
Query: 3330 QD-CTQNYLQLQDSPQGHGNSRF-QFCGRNASAVPVFYSSMSTAMVI 3374
C + + + + + R +FCG AVP SS +++
Sbjct: 210 DTYCRYDSVSVFNGAVSDDSRRLGKFCG---DAVPGSISSEGNELLV 253
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 148 bits (373), Expect = 1e-34
Identities = 123/400 (30%), Positives = 170/400 (42%), Gaps = 97/400 (24%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSA----DVNECEIYSGTPLSCQN 186
+D+ S + C G C+N SF C C ++ D++ECE PL C+
Sbjct: 1116 IDECRISPDLC-GSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECE---RNPLLCR- 1170
Query: 187 GGTCVNTMGSYSCHCPPETYGPQCASKYDDCE-----GGSVARCVHGICEDLMREQAGEP 241
GGTCVNT GS+ C CP G + + +DC S C +G C +++
Sbjct: 1171 GGTCVNTEGSFQCDCP---LGHELSPSREDCVDINECSLSDNLCRNGKCVNMI------G 1221
Query: 242 KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW----- 296
Y C C+ G+ +P+ CT D DEC G C T QC N++GS+ C +C G+
Sbjct: 1222 TYQCSCNPGYQATPDRQGCT-DIDECMIMNGGCDT--QCTNSEGSYEC-SCSEGYALMPD 1277
Query: 297 ----------QGNGYICE-----------------------------DINECEINNGGCS 317
+ N IC+ D+NEC++N+ C
Sbjct: 1278 GRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICM 1337
Query: 318 VAPPVECVNTPGSSHCQACPPGY--QGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPL 375
EC NT GS C C GY + CT D C + C ASC + GS
Sbjct: 1338 FG---ECENTKGSFICH-CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFK- 1392
Query: 376 CTCLPGYTGNGYGPNGCVQLSNICL-SHPC-LNGQCIDTVSGYFCKCDSGWTG------- 426
C+C G+ GNG C+ L +H C +N QC++T Y C C G+TG
Sbjct: 1393 CSCREGWIGNGI---KCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSD 1449
Query: 427 -VNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGA 465
C ENIN C + CLN V G ++ CEC +T A
Sbjct: 1450 VDECAENINLCENGQCLN----VPG--AYRCECEMGFTPA 1483
Score = 142 bits (359), Expect = 5e-33
Identities = 125/395 (31%), Positives = 176/395 (44%), Gaps = 77/395 (19%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW-KGPLCSA--DVNECEIYSGTPLSCQNG 187
+D C+SNPC NG C+N S++C C + + P A D++EC I +G + C+NG
Sbjct: 534 IDVDECTSNPCTNGD-CVNTPGSYYCKCHAGFQRTPTKQACIDIDEC-IQNG--VLCKNG 589
Query: 188 GTCVNTMGSYSCHCPP----ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
CVNT GS+ C C T G C +D+C ++ C++G+C + + +
Sbjct: 590 -RCVNTDGSFQCICNAGFELTTDGKNCVD-HDECTTTNM--CLNGMCIN------EDGSF 639
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG--NGY 301
C+C G++ +PN CT D DEC PG C C N++GSF C CP G +G
Sbjct: 640 KCICKPGFVLAPNGRYCT-DVDECQ-TPGICMN-GHCINSEGSFRCD-CPPGLAVGMDGR 695
Query: 302 ICEDINECEINNGGCSVAPPVE-----------CVNTPG---SSHCQACPP--------- 338
+C D + GG V C P CQ CP
Sbjct: 696 VCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGL 755
Query: 339 -----GYQGDGR---VCTLT-DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGP 389
G DGR C L DIC+ + C + GS C C GY + G
Sbjct: 756 CSSGVGITVDGRDINECALDPDICA--------NGICENLRGSYR-CNCNSGYEPDASGR 806
Query: 390 NGCVQLSNICLSHP-CLNGQCIDTVSGYFCKCDSGW---TGVNCTENINECLSNPCLNGG 445
N C+ + ++ C NG C +T Y C C G+ T E+INEC SNPC+NG
Sbjct: 807 N-CIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGA 865
Query: 446 TCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG 480
C + + SF+CEC+ G+ +C +SL G
Sbjct: 866 -CRNNLGSFNCECS---PGSKLSSTGLICIDSLKG 896
Score = 140 bits (354), Expect = 2e-32
Identities = 108/339 (31%), Positives = 149/339 (43%), Gaps = 50/339 (14%)
Query: 136 CSSNP--CQNGGTCLNLHDSFFCICPPQWKGPL---CSADVNECEIYSGTPLSCQNGGTC 190
C +NP C +GG C N+ + C+C + + DVNEC++ S + G C
Sbjct: 1287 CENNPDIC-DGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMF----GEC 1341
Query: 191 VNTMGSYSCHCP---PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVC 247
NT GS+ CHC G + D+CE G+ +H C ++ + C C
Sbjct: 1342 ENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI------PGSFKCSC 1395
Query: 248 DAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDIN 307
GW+ N C +D DECS CS QC NT GS+ C AC G+ G+G+ C D++
Sbjct: 1396 REGWI--GNGIKC-IDLDECSNGTHQCSINAQCVNTPGSYRC-ACSEGFTGDGFTCSDVD 1451
Query: 308 ECEINNGGCSVAPPVECVNTPGSSHCQACPPGY--QGDGRVCTLTDICSVSN----GGCH 361
EC N C +C+N PG+ C+ C G+ D R C D CS N G C
Sbjct: 1452 ECAENINLCENG---QCLNVPGAYRCE-CEMGFTPASDSRSCQDIDECSFQNICVFGTC- 1506
Query: 362 PDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCD 421
+ L + C C GY + G N C + C+NG C++T Y C C
Sbjct: 1507 ------NNLPGMFHCICDDGYELDRTGGN-CTDIDECADPINCVNGLCVNTPGRYECNCP 1559
Query: 422 SGW----TGVNCTENINECLSNPCLNGGTCVDGVDSFSC 456
+ TGV C +N + N L G DG S SC
Sbjct: 1560 PDFQLNPTGVGCVDN---RVGNCYLKFGPRGDG--SLSC 1593
Score = 140 bits (354), Expect = 2e-32
Identities = 118/408 (28%), Positives = 165/408 (40%), Gaps = 95/408 (23%)
Query: 129 QTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNEC----------- 174
+ +D+ N CQ C+N S+ C C +K C D NEC
Sbjct: 1849 EDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC-VDRNECLEIPNVCSHGL 1907
Query: 175 --EIYSGTPLSCQNG-----------------------GTCVNTMGSYSCHCPPE---TY 206
++ C NG GTC NT+GSY+C C P T+
Sbjct: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967
Query: 207 GPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDE 266
C D+C C +G C + + + C+C+ G+ +P+ C +D +E
Sbjct: 1968 NNDCLD-IDECSSFFGQVCRNGRCFNEI------GSFKCLCNEGYELTPDGKNC-IDTNE 2019
Query: 267 CSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVN 326
C PG CS C N +GSF C CP G++ C DINEC+ + C C N
Sbjct: 2020 CVALPGSCSP-GTCQNLEGSFRC-ICPPGYEVKSENCIDINECDEDPNICLFG---SCTN 2074
Query: 327 TPGSSHCQACPPGY--QGDGRVC--TLTDIC--SVSNGGCHPDASCSSTLGSLPLCTCLP 380
TPG C CPPG+ +GR C T C + NG C + ++T C+ +P
Sbjct: 2075 TPGGFQC-LCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC-CCSKMP 2132
Query: 381 GY----------------------TGNGYGP--NGCVQLSNICLSHP--CLNGQCIDTVS 414
G G+G P + + N CL P C NGQCI+T
Sbjct: 2133 GEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDG 2192
Query: 415 GYFCKCDSG----WTGVNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
+ C+C G +TGV C + + NPC N GTC + + SF C C
Sbjct: 2193 SFRCECPMGYNLDYTGVRCVDTDECSIGNPCGN-GTCTNVIGSFECNC 2239
Score = 134 bits (337), Expect = 2e-30
Identities = 119/411 (28%), Positives = 165/411 (40%), Gaps = 105/411 (25%)
Query: 131 VDKKVCSSNP--CQNGGTCLNLHDSFFCICPPQWKGP----LCSADVNECEIYSGTPLSC 184
VD+ C P C +G C++L S+ CIC +K +C DV+ECE + C
Sbjct: 1891 VDRNECLEIPNVCSHG-LCVDLQGSYQCICHNGFKASQDQTMCM-DVDECERHP-----C 1943
Query: 185 QNGGTCVNTMGSYSCHCPPE---TYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEP 241
NG TC NT+GSY+C C P T+ C D+C C +G C + +
Sbjct: 1944 GNG-TCKNTVGSYNCLCYPGFELTHNNDCLD-IDECSSFFGQVCRNGRCFNEIGS----- 1996
Query: 242 KYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGY 301
+ C+C+ G+ +P+ C +D +EC PG CS C N +GSF C CP G++
Sbjct: 1997 -FKCLCNEGYELTPDGKNC-IDTNECVALPGSCSPGT-CQNLEGSFRC-ICPPGYEVKSE 2052
Query: 302 ICEDINECE----------------------------------------------INNGG 315
C DINEC+ NG
Sbjct: 2053 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK 2112
Query: 316 CSVAPPVE-------CVNTPGSSH---CQACPPGYQ---------GDGRVCTLTDI---- 352
CSV C PG C+ CP + G G V +L D
Sbjct: 2113 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV 2172
Query: 353 --CSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCI 410
C S G C + C +T GS C C GY + G CV + +PC NG C
Sbjct: 2173 NECLESPGICS-NGQCINTDGSFR-CECPMGYNLDYTGVR-CVDTDECSIGNPCGNGTCT 2229
Query: 411 DTVSGYFCKCDSGWTG---VNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
+ + + C C+ G+ +NC E+INEC NP L C++ S+ C C
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMNC-EDINECAQNPLLCAFRCMNTFGSYECTC 2279
Score = 127 bits (320), Expect = 2e-28
Identities = 117/410 (28%), Positives = 162/410 (39%), Gaps = 66/410 (16%)
Query: 141 CQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
CQ GG C+N SF C CP + + D++EC + G C GTC NT+G+Y
Sbjct: 1661 CQ-GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGV---C-GPGTCYNTLGNY 1715
Query: 198 SCHCPPETYGPQCASKYDDCEGGSVARCVHG-ICEDLMREQAGEPKYSCVCDAGWMFSPN 256
+C CPPE D R +G CE+ + + C + G ++
Sbjct: 1716 TCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP 1775
Query: 257 SPAC--------------------------TLDRDECSFQPGPCSTLVQCFNTQGSFYCG 290
C +D DEC PG C+ V C N GSF C
Sbjct: 1776 CEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSFRC- 1833
Query: 291 ACPTGWQGNG--YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQ--GDGRV 346
CPTG+ N +CEDI+EC +NG +C+N+PGS C+ C G++ +G
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDEC--SNGDNLCQRNADCINSPGSYRCE-CAAGFKLSPNGAC 1890
Query: 347 CTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLN 406
+ + N H C GS C C G+ + C+ + C HPC N
Sbjct: 1891 VDRNECLEIPNVCSH--GLCVDLQGSYQ-CICHNGFKAS-QDQTMCMDVDE-CERHPCGN 1945
Query: 407 GQCIDTVSGYFCKCDSGW--TGVNCTENINECLS---NPCLNGGTCVDGVDSFSCECTR- 460
G C +TV Y C C G+ T N +I+EC S C N G C + + SF C C
Sbjct: 1946 GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEG 2004
Query: 461 ----------LWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500
+ T +P + + GSF P V NC
Sbjct: 2005 YELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENC 2054
Score = 124 bits (310), Expect = 2e-27
Identities = 130/447 (29%), Positives = 185/447 (41%), Gaps = 96/447 (21%)
Query: 96 KGSAIGLPQNISSQIYQLNSKLVDLERKFQ-----GLQQTVDKKVC-------SSNPCQN 143
K + I + + I + + N + V+ + FQ G + T D K C ++N C N
Sbjct: 570 KQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLN 629
Query: 144 GGTCLNLHDSFFCICPPQW----KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSC 199
G C+N SF CIC P + G C+ DV+EC+ TP C NG C+N+ GS+ C
Sbjct: 630 G-MCINEDGSFKCICKPGFVLAPNGRYCT-DVDECQ----TPGICMNGH-CINSEGSFRC 682
Query: 200 HCPPETY----GPQCASKY--DDCEGG-SVARCVHGICEDLMREQA---------GEPKY 243
CPP G C + C GG CV + + + GEP
Sbjct: 683 DCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ 742
Query: 244 SC----------VCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACP 293
C +C +G + + D +EC+ P C+ + C N +GS+ C C
Sbjct: 743 PCPAKNSAEFHGLCSSGVGITVDGR----DINECALDPDICANGI-CENLRGSYRCN-CN 796
Query: 294 TGWQ--GNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTD 351
+G++ +G C DI+EC +N C C NTPGS C CPPGY T D
Sbjct: 797 SGYEPDASGRNCIDIDECLVNRLLCDNGL---CRNTPGSYSC-TCPPGYVFRTETETCED 852
Query: 352 ICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNIC------------ 399
I + C + +C + LGS C C PG + G L C
Sbjct: 853 INECESNPC-VNGACRNNLGSFN-CECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVN 910
Query: 400 LSHPCLNGQCIDTVSGYF------CKCDSGWT-------GVNCTENINECLSNP--CLNG 444
++ L +C T+ + C+ D+ GV C E++NEC P C NG
Sbjct: 911 INGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTC-EDVNECEVFPGVCPNG 969
Query: 445 GTCVDGVDSFSCEC----TRLWTGALC 467
CV+ SF CEC T TG +C
Sbjct: 970 -RCVNSKGSFHCECPEGLTLDGTGRVC 995
Score = 123 bits (309), Expect = 3e-27
Identities = 123/400 (30%), Positives = 164/400 (41%), Gaps = 67/400 (16%)
Query: 122 RKFQGLQQTVDKKVCSSNPCQNGGT-CLNLHDSFFCICPPQWK----GPLCSADVNECEI 176
R+ Q + + +D+ + C++ G C NL +F CICPP G C D NEC
Sbjct: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRT 2344
Query: 177 YSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDC----EGGSVARCVHGICED 232
G C+NG CVN +GSY C C G Q +S +C +G A + IC+
Sbjct: 2345 KPGI---CENG-RCVNIIGSYRCEC---NEGFQSSSSGTECLDNRQGLCFAEVLQTICQM 2397
Query: 233 LMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGAC 292
+ K C CD G + C L PG Y C
Sbjct: 2398 ASSSRNLVTKSECCCDGGRGWGHQCELCPL--------PGTAQ------------YKKIC 2437
Query: 293 PTGWQGNGYICE--DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD--GRVCT 348
P G GY + DI+EC++ C+ +C+NT GS C C GY D G C
Sbjct: 2438 P---HGPGYTTDGRDIDECKVMPNLCTNG---QCINTMGSFRC-FCKVGYTTDISGTSCI 2490
Query: 349 LTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQ 408
D CS S C+ C +T GS C+C GY G C L
Sbjct: 2491 DLDECSQSPKPCN--YICKNTEGSYQ-CSCPRGYVLQEDGKT-CKDLDECQTKQHNCQFL 2546
Query: 409 CIDTVSGYFCKCDSGWTGVN--CTENINECLSNPCLNG--GTCVDGVDSFSCECTRLW-- 462
C++T+ G+ CKC G+T + C +N NEC S P L G G C + SFSCEC R +
Sbjct: 2547 CVNTLGGFTCKCPPGFTQHHTACIDN-NECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
Query: 463 --TGALCQVPQQV-----CGESLSGINGSFSYRSPDVGYV 495
TG C+ + C I G + P GY+
Sbjct: 2606 DATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQ-GYI 2644
Score = 122 bits (305), Expect = 8e-27
Identities = 114/404 (28%), Positives = 163/404 (40%), Gaps = 80/404 (19%)
Query: 131 VDKKVCS-SNPCQNGGTCLNLHDSFFCICPPQWK-GPLCSA-DVNECEIYSGTPLSCQNG 187
VD CS NPC NG TC N+ SF C C ++ GP+ + D+NEC + PL C
Sbjct: 2212 VDTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMNCEDINEC---AQNPLLC--A 2265
Query: 188 GTCVNTMGSYSCHCPPETYG-----------PQCASKYDDCEGGSVARCVHGICEDLMRE 236
C+NT GSY C CP Y +CA DCE + +C++L+
Sbjct: 2266 FRCMNTFGSYECTCPIG-YALREDQKMCKDLDECAEGLHDCESRGM------MCKNLIGT 2318
Query: 237 QAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW 296
+ C+C G P+ C +D +EC +PG C +C N GS+ C C G+
Sbjct: 2319 ------FMCICPPGMARRPDGEGC-VDENECRTKPGICEN-GRCVNIIGSYRC-ECNEGF 2369
Query: 297 QGNGYICEDINECEINNGGCSVAPPVECVNTPGSSH------CQACPPGYQGDGRVCTLT 350
Q + EC N G A ++ + SS + C G +G G C L
Sbjct: 2370 QSSS----SGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC 2425
Query: 351 DICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCI 410
+ T +C PGYT +G + C + N+C NGQCI
Sbjct: 2426 PL--------------PGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCT-----NGQCI 2466
Query: 411 DTVSGYFCKCDSGWT----GVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWT--- 463
+T+ + C C G+T G +C + ++EC +P C + S+ C C R +
Sbjct: 2467 NTMGSFRCFCKVGYTTDISGTSCID-LDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQE 2525
Query: 464 -GAL------CQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500
G CQ Q C G F+ + P H C
Sbjct: 2526 DGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTAC 2569
Score = 121 bits (303), Expect = 1e-26
Identities = 115/393 (29%), Positives = 159/393 (40%), Gaps = 97/393 (24%)
Query: 145 GTCLNLHDSFFCICPPQWK----GPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
GTC NL F CIC ++ G C+ D++EC P++C NG CVNT G Y C+
Sbjct: 1504 GTCNNLPGMFHCICDDGYELDRTGGNCT-DIDEC----ADPINCVNG-LCVNTPGRYECN 1557
Query: 201 CPPE----TYGPQCA-SKYDDC------EGGSVARCVHGICEDLMREQA--------GEP 241
CPP+ G C ++ +C G C I + R G P
Sbjct: 1558 CPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNP 1617
Query: 242 ----------KYSCVCDAGWMFSPNSPACTL-DRDECSFQPGPCSTLVQCFNTQGSFYCG 290
+Y +C G F PN L D DEC PG C C NT GSF C
Sbjct: 1618 CETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG-GNCINTFGSFQC- 1675
Query: 291 ACPTGW--QGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGY-QGDG--- 344
CP G+ + ICEDI+EC + G C P C NT G+ C CPP Y Q +G
Sbjct: 1676 ECPQGYYLSEDTRICEDIDECFAHPGVCG---PGTCYNTLGNYTC-ICPPEYMQVNGGHN 1731
Query: 345 ----------------------------RVCTLT-DICSVSNGGCHPDASCSSTLGSLPL 375
R+C T ++ N C P T +
Sbjct: 1732 CMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP-CPTPGTADFKTI 1790
Query: 376 CTCLPGY-----TGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTG---V 427
C +PG+ TG + C ++ I C NG CI+ + + C+C +G++ +
Sbjct: 1791 CGNIPGFTFDIHTGKAVDIDECKEIPGI-----CANGVCINQIGSFRCECPTGFSYNDLL 1845
Query: 428 NCTENINECLS--NPCLNGGTCVDGVDSFSCEC 458
E+I+EC + N C C++ S+ CEC
Sbjct: 1846 LVCEDIDECSNGDNLCQRNADCINSPGSYRCEC 1878
Score = 119 bits (298), Expect = 5e-26
Identities = 102/364 (28%), Positives = 158/364 (43%), Gaps = 56/364 (15%)
Query: 131 VDKKVCSSNP--CQNGGTCLNLHDSFFCICPPQWKGP------------LCSADVNE--C 174
VD+ C + P C+NG C+N+ S+ C C ++ LC A+V + C
Sbjct: 2337 VDENECRTKPGICENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTIC 2395
Query: 175 EIYSGTP-LSCQNGGTCVNTMG-SYSCH-CP-PET--------YGPQCASKYDDCEGGSV 222
++ S + L ++ C G + C CP P T +GP + D + V
Sbjct: 2396 QMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKV 2455
Query: 223 AR--CVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQC 280
C +G C + M + C C G+ + +C +D DECS P PC+ + C
Sbjct: 2456 MPNLCTNGQCINTMGS------FRCFCKVGYTTDISGTSC-IDLDECSQSPKPCNYI--C 2506
Query: 281 FNTQGSFYCGACPTGW--QGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPP 338
NT+GS+ C +CP G+ Q +G C+D++EC+ C CVNT G C+ CPP
Sbjct: 2507 KNTEGSYQC-SCPRGYVLQEDGKTCKDLDECQTKQHNCQFL----CVNTLGGFTCK-CPP 2560
Query: 339 GYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNI 398
G+ C + C C C +T GS C C G++ + G N C +
Sbjct: 2561 GFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS-CECQRGFSLDATGLN-CEDVDEC 2618
Query: 399 CLSHPCLNGQCIDTVSGYFCKCDSGWTGV----NCTENINECLSNPCLNGGTCVDGVDSF 454
+H C +G C + + GY C C G+ C + NEC + +C + + S+
Sbjct: 2619 DGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDE-NECSNPNACGSASCYNTLGSY 2676
Query: 455 SCEC 458
C C
Sbjct: 2677 KCAC 2680
Score = 117 bits (293), Expect = 2e-25
Identities = 100/307 (32%), Positives = 139/307 (45%), Gaps = 45/307 (14%)
Query: 170 DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPE---TYGPQCASKYDDCEGGSVARCV 226
D+NEC+ + G C G C NT+GS+ C C + + D+C S C
Sbjct: 1073 DINECKAFPGM---CTYG-KCRNTIGSFKCRCNSGFALDMEERNCTDIDECR-ISPDLCG 1127
Query: 227 HGICEDLMREQAGEPKYSCVC----DAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFN 282
GIC + + C C ++G+M N +D DEC P C C N
Sbjct: 1128 SGICVNT------PGSFECECFEGYESGFMMMKN----CMDIDECERNPLLCRG-GTCVN 1176
Query: 283 TQGSFYCGACPTGWQ--GNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGY 340
T+GSF C CP G + + C DINEC +++ C +CVN G+ C +C PGY
Sbjct: 1177 TEGSFQCD-CPLGHELSPSREDCVDINECSLSDNLCRNG---KCVNMIGTYQC-SCNPGY 1231
Query: 341 QG--DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNI 398
Q D + CT D C + NGGC D C+++ GS C+C GY G C +
Sbjct: 1232 QATPDRQGCTDIDECMIMNGGC--DTQCTNSEGSYE-CSCSEGYALMPDG-RSCADIDE- 1286
Query: 399 CLSHP--CLNGQCIDTVSGYFCKCDSGWTG---VNCTENINEC--LSNPCLNGGTCVDGV 451
C ++P C GQC + Y C C G+ + ++NEC SN C+ G C +
Sbjct: 1287 CENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICM-FGECENTK 1345
Query: 452 DSFSCEC 458
SF C C
Sbjct: 1346 GSFICHC 1352
Score = 111 bits (277), Expect = 1e-23
Identities = 112/397 (28%), Positives = 155/397 (39%), Gaps = 88/397 (22%)
Query: 135 VCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSG-TPLSCQNGGTCVNT 193
VC N CQNGG C+ + C C + GP C D ++ CQ T +
Sbjct: 179 VCE-NGCQNGGRCIGPNR---CACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVC 234
Query: 194 MGSYSCHCPPETYG---PQCASKYDDCEGGSVARCVHGICEDLMREQA------------ 238
+ C +G C ++ C G + G C+D+ QA
Sbjct: 235 TKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCIN 294
Query: 239 GEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW-- 296
+ C C AG S + C D DECS PG C T +C NT GS++C CP G+
Sbjct: 295 TVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICET-GECSNTVGSYFC-VCPRGYVT 351
Query: 297 --QGNGYICEDINEC--EINNGGCSVAPP-----VECVNTPG-----SSHCQACP-PGYQ 341
G+ I + C + NG C+ P ++C PG + +ACP G +
Sbjct: 352 STDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSE 411
Query: 342 GDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNG---------- 391
R+C + + GG S S G P GNGYGP G
Sbjct: 412 EYRRLC----MDGLPMGGI--PGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGN 465
Query: 392 -------------------------CVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW 424
Q +IC H CLNG+CI TVS Y C+C+ G+
Sbjct: 466 GFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGY 525
Query: 425 ---TGVNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
+C + ++EC SNPC N G CV+ S+ C+C
Sbjct: 526 KQDANGDCID-VDECTSNPCTN-GDCVNTPGSYYCKC 560
Score = 109 bits (272), Expect = 6e-23
Identities = 101/325 (31%), Positives = 134/325 (41%), Gaps = 42/325 (12%)
Query: 131 VDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW----KGPLCSADVNECEIYSGTPLSCQN 186
+D+ N C NG C+N SF C C + G C D++EC S +P C
Sbjct: 2450 IDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTSC-IDLDEC---SQSPKPCNY 2504
Query: 187 GGTCVNTMGSYSCHCPP----ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
C NT GSY C CP + G C D+C+ H C+ L G
Sbjct: 2505 --ICKNTEGSYQCSCPRGYVLQEDGKTCKD-LDECQTKQ-----HN-CQFLCVNTLGG-- 2553
Query: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNG 300
++C C G F+ + AC +D +EC QP C C NT GSF C C G+ G
Sbjct: 2554 FTCKCPPG--FTQHHTAC-IDNNECGSQPSLCGAKGICQNTPGSFSC-ECQRGFSLDATG 2609
Query: 301 YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC 360
CED++EC+ N C C N G C CP GY + D SN
Sbjct: 2610 LNCEDVDECD-GNHRCQHG----CQNILGGYRC-GCPQGYIQHYQWNQCVDENECSNPNA 2663
Query: 361 HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC 420
ASC +TLGS C C G++ + + + C ++ S N C +T GY C C
Sbjct: 2664 CGSASCYNTLGSYK-CACPSGFSFDQFS-SACHDVNECSSSKNPCNYGCSNTEGGYLCGC 2721
Query: 421 DSGWTGVNCTENINECLSNPCLNGG 445
G+ V C+S N G
Sbjct: 2722 PPGYYRV----GQGHCVSGMGFNKG 2742
Score = 102 bits (254), Expect = 7e-21
Identities = 108/355 (30%), Positives = 142/355 (40%), Gaps = 46/355 (12%)
Query: 126 GLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCS---ADVNECEIYSGTPL 182
G Q VD+ CQ GG C+N SF C CP K + D++EC I G
Sbjct: 272 GACQDVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGI-- 328
Query: 183 SCQNGGTCVNTMGSYSCHCP----PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQA 238
C+ G C NT+GSY C CP T G +C D G + V+G C +E
Sbjct: 329 -CET-GECSNTVGSYFCVCPRGYVTSTDGSRC---IDQRTGMCFSGLVNGRC---AQELP 380
Query: 239 GE-PKYSCVCDAG--WMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTG 295
G K C C+ G W AC + E C + GS G+ P G
Sbjct: 381 GRMTKMQCCCEPGRCWGIGTIPEACPVRGSE--EYRRLCMDGLPMGGIPGS--AGSRPGG 436
Query: 296 WQGNGYICEDINECEINNGGCSVAP-PVECVNTPGSSHCQACPPGYQGDGRVCT------ 348
GNG+ N GG P P +PG G G G + T
Sbjct: 437 TGGNGF-APSGNGNGYGPGGTGFIPIPGGNGFSPGVG---GAGVGAGGQGPIITGLTILN 492
Query: 349 -LTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNG 407
DIC C + C T+ S C C GY + G C+ + C S+PC NG
Sbjct: 493 QTIDICKHHANLC-LNGRCIPTVSSY-RCECNMGYKQDANG--DCIDVDE-CTSNPCTNG 547
Query: 408 QCIDTVSGYFCKCDSGWTGVNCTE---NINECLSNPCL-NGGTCVDGVDSFSCEC 458
C++T Y+CKC +G+ + +I+EC+ N L G CV+ SF C C
Sbjct: 548 DCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCIC 602
Score = 100 bits (249), Expect = 3e-20
Identities = 116/394 (29%), Positives = 147/394 (37%), Gaps = 101/394 (25%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCH 200
C NGGTC + H C C + G C V CE CQNGG C+ G C
Sbjct: 153 CMNGGTCADDH----CQCQKGYIGTYCGQPV--CE------NGCQNGGRCI---GPNRCA 197
Query: 201 CPPETYGPQCASKY-----------DDCEGGSVA-RCVHGICEDLMREQAGEPKYSC--- 245
C GPQC Y C+G C +C + G P C
Sbjct: 198 CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Query: 246 --VCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI- 302
C G++ + + AC D DEC PG C C NT GSF C CP G + +
Sbjct: 258 PQPCRRGFIPNIRTGACQ-DVDECQAIPGICQG-GNCINTVGSFEC-RCPAGHKQSETTQ 314
Query: 303 -CEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGY--QGDGRVC--TLTDIC--SV 355
CEDI+EC I G C EC NT GS C CP GY DG C T +C +
Sbjct: 315 KCEDIDECSIIPGICETG---ECSNTVGSYFC-VCPRGYVTSTDGSRCIDQRTGMCFSGL 370
Query: 356 SNGGCHPDASCSST-------------LGSLP-------------LCT------------ 377
NG C + T +G++P LC
Sbjct: 371 VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSA 430
Query: 378 -----------CLPGYTGNGYGPNGC--VQLSNICLSHPCLNGQCIDTVSGYFCKCDSGW 424
P GNGYGP G + + P + G + +G +G
Sbjct: 431 GSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVG--AGGQGPIITGL 488
Query: 425 TGVNCTENINECLSNPCLNGGTCVDGVDSFSCEC 458
T +N T +I + +N CLN G C+ V S+ CEC
Sbjct: 489 TILNQTIDICKHHANLCLN-GRCIPTVSSYRCEC 521
Score = 80.9 bits (198), Expect = 2e-14
Identities = 62/191 (32%), Positives = 89/191 (46%), Gaps = 26/191 (13%)
Query: 279 QCFNTQGSFYCGACPTGWQ--GNGYICEDINECEIN---NGGCSVAPPVECVNTPGSSHC 333
+C T S+ C C G++ NG C D++EC N NG +CVNTPGS +C
Sbjct: 509 RCIPTVSSYRC-ECNMGYKQDANGD-CIDVDECTSNPCTNG--------DCVNTPGSYYC 558
Query: 334 QACPPGYQGDG--RVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNG 391
+ C G+Q + C D C + NG + C +T GS C C G+ G N
Sbjct: 559 K-CHAGFQRTPTKQACIDIDEC-IQNGVLCKNGRCVNTDGSFQ-CICNAGFELTTDGKN- 614
Query: 392 CVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWT----GVNCTENINECLSNPCLNGGTC 447
CV ++ CLNG CI+ + C C G+ G CT+ ++EC + G C
Sbjct: 615 CVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTD-VDECQTPGICMNGHC 673
Query: 448 VDGVDSFSCEC 458
++ SF C+C
Sbjct: 674 INSEGSFRCDC 684
Score = 58.2 bits (139), Expect = 1e-07
Identities = 56/171 (32%), Positives = 69/171 (40%), Gaps = 27/171 (15%)
Query: 41 QPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSEC--LHQIQKNKEDIIELKGS 98
QP + +G GS R SL LN ED+ EC H+ Q ++I L G
Sbjct: 2578 QPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNI--LGGY 2635
Query: 99 AIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCIC 158
G PQ Q YQ N Q VD+ CS+ +C N S+ C C
Sbjct: 2636 RCGCPQGYI-QHYQWN--------------QCVDENECSNPNACGSASCYNTLGSYKCAC 2680
Query: 159 PPQWKGPLCSA---DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETY 206
P + S+ DVNEC S + C G C NT G Y C CPP Y
Sbjct: 2681 PSGFSFDQFSSACHDVNEC---SSSKNPCNYG--CSNTEGGYLCGCPPGYY 2726
Score = 53.5 bits (127), Expect = 4e-06
Identities = 50/169 (29%), Positives = 65/169 (38%), Gaps = 36/169 (21%)
Query: 326 NTPGSSHCQACPPGYQG--DGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYT 383
N GS C PG++ G C + IC S G D CS +CTC G
Sbjct: 87 NVCGSRFHSYCCPGWKTLPGGNQC-IVPICRNSCG----DGFCSRP----NMCTCSSGQI 137
Query: 384 GNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLN 443
+ G Q S C++ G C D C+C G+ G C + + E N C N
Sbjct: 138 SSTCGSKSIQQCSVRCMN----GGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQN 186
Query: 444 GGTCVDGVDSFSCECTRLWTGALC-----------QVPQQVCGESLSGI 481
GG C+ C C +TG C QV Q+C L+GI
Sbjct: 187 GGRCIG---PNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGI 232
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 148 bits (373), Expect = 1e-34
Identities = 114/347 (32%), Positives = 161/347 (46%), Gaps = 44/347 (12%)
Query: 128 QQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQW----KGPLCSADVNECEIYSGTPLS 183
Q+ D C +GG C N S+ C C + KG D+NEC P +
Sbjct: 926 QECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH--CQDINECR----HPGT 979
Query: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKY 243
C + G CVN+ GSY+C E Y Q S D E + C HG C +L E +
Sbjct: 980 CPD-GRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNL------EGSF 1032
Query: 244 SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGN--GY 301
C C+ G+ + + C D DEC+ + C T + C NT+GSF C AC G+ N G
Sbjct: 1033 RCSCEQGYEVTSDEKGCQ-DVDECASR-ASCPTGL-CLNTEGSFACSACENGYWVNEDGT 1089
Query: 302 ICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD--GRVCTLTDICSVSNGG 359
CED++EC V P C NT GS C+ C GY+ G C D C
Sbjct: 1090 ACEDLDECAFP----GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSS 1145
Query: 360 CHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCV-QLSNICL--SHPCLNGQCIDTVSGY 416
C C +T+GS C C G+ NG V + N C+ H +G+C+++ +
Sbjct: 1146 C-LGGECKNTVGSYQ-CLCPQGF----QLANGTVCEDVNECMGEEHCAPHGECLNSHGSF 1199
Query: 417 FCKCDSGWT----GVNCTENINEC-LSNPCLNGGTCVDGVDSFSCEC 458
FC C G+ G +C ++++EC ++PC+ GG CV+ SF+C C
Sbjct: 1200 FCLCAPGFVSAEGGTSC-QDVDECATTDPCV-GGHCVNTEGSFNCLC 1244
Score = 145 bits (367), Expect = 5e-34
Identities = 115/360 (31%), Positives = 161/360 (44%), Gaps = 48/360 (13%)
Query: 137 SSNPCQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGTPLSCQNGGTCVNT 193
++N C GTC+NL D + C+C P ++ D NEC C+ G C+N
Sbjct: 852 ATNVC-GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC-----LRDPCKGKGRCINR 905
Query: 194 MGSYSCHCPP-----ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCD 248
+GSYSC C P + Q ++CE V C G C + E Y C CD
Sbjct: 906 VGSYSCFCYPGYTLATSGATQECQDINECEQPGV--CSGGQCTNT------EGSYHCECD 957
Query: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINE 308
G++ D +EC PG C +C N+ GS+ C AC G++G C D+NE
Sbjct: 958 QGYIMVRKGHC--QDINECR-HPGTCPD-GRCVNSPGSYTCLACEEGYRGQSGSCVDVNE 1013
Query: 309 CEINNGGCSVAPPVECVNTPGSSHCQACPPGYQ--GDGRVCTLTDICSVSNGGCHPDASC 366
C + G C+ +C N GS C +C GY+ D + C D C+ S C P C
Sbjct: 1014 C-LTPGVCAHG---KCTNLEGSFRC-SCEQGYEVTSDEKGCQDVDECA-SRASC-PTGLC 1066
Query: 367 SSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCK-CDSGW- 424
+T GS C GY N G C L C +G C +T + CK CD G+
Sbjct: 1067 LNTEGSFACSACENGYWVNEDG-TACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYR 1125
Query: 425 ---TGVNCTENINEC--LSNPCLNGGTCVDGVDSFSCECT---RLWTGALCQVPQQVCGE 476
G +C E+++EC + CL GG C + V S+ C C +L G +C+ + GE
Sbjct: 1126 PSPLGDSC-EDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGE 1183
Score = 118 bits (295), Expect = 1e-25
Identities = 120/409 (29%), Positives = 157/409 (38%), Gaps = 93/409 (22%)
Query: 141 CQNGGTCLNLHDSFFCICPPQW---KGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSY 197
C G CLN H SFFC+C P + +G DV+EC T C GG CVNT GS+
Sbjct: 1186 CAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC----ATTDPCV-GGHCVNTEGSF 1240
Query: 198 SCHCP----PETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCV--CDAGW 251
+C C P +C D+CE C CE+ Y CV C G+
Sbjct: 1241 NCLCETGFQPSPESGECVD-IDECEDYGDPVCGTWKCEN------SPGSYRCVLGCQPGF 1293
Query: 252 MFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQ--GNGYICEDINEC 309
+PN +D DEC+ C + C NT GSF C C G++ +G+ C D+NEC
Sbjct: 1294 HMAPNGDC--IDIDECA-NDTMCGSHGFCDNTDGSFRC-LCDQGFEISPSGWDCVDVNEC 1349
Query: 310 EINNGGCSVAPPVECVNTPGS----------------SHCQACPPGYQGDGRVCTLTDIC 353
E+ C A C N GS HC+ G Q T
Sbjct: 1350 ELMLAVCGAAL---CENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAP 1406
Query: 354 SVSNGGCHPD----ASCSSTLG---SLPLCTCLPGYT----------------------G 384
+ + C+ A CSS LG + C C G + G
Sbjct: 1407 APTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSG 1466
Query: 385 NGY---------GPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGW---TGVNCT 430
GY G + P C NG+C++TV GY C C+ G+
Sbjct: 1467 KGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKC 1526
Query: 431 ENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLS 479
E+ +EC C N G CV+ SF C C+ T + QQ C S S
Sbjct: 1527 EDHDECQDLACEN-GECVNTEGSFHCFCSPPLT---LDLSQQRCMNSTS 1571
Score = 73.6 bits (179), Expect = 3e-12
Identities = 51/148 (34%), Positives = 63/148 (42%), Gaps = 9/148 (6%)
Query: 314 GGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSL 373
G +V P CVN P C C PGYQ TD C C + +GS
Sbjct: 851 GATNVCGPGTCVNLPDGYRC-VCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSY 909
Query: 374 PLCTCLPGYTGNGYGPNGCVQLSNICLSHP--CLNGQCIDTVSGYFCKCDSGWTGV---N 428
C C PGYT G Q N C P C GQC +T Y C+CD G+ V +
Sbjct: 910 S-CFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH 967
Query: 429 CTENINECLSNPCLNGGTCVDGVDSFSC 456
C ++INEC G CV+ S++C
Sbjct: 968 C-QDINECRHPGTCPDGRCVNSPGSYTC 994
Score = 53.9 bits (128), Expect = 3e-06
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 12/97 (12%)
Query: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWK---GPLCSADVNECEIYSGT 180
F+GLQ ++ N C+NG C+ + + + C C ++ + DVNEC+ +G
Sbjct: 1729 FEGLQA---EECGILNGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGP 1784
Query: 181 PLSCQNGGTCVNTMGSYSCHCPP----ETYGPQCASK 213
+ C +G C NT GSY CHC P E P C +K
Sbjct: 1785 AVLCVHG-YCENTEGSYRCHCSPGYVAEAGPPHCTAK 1820
Score = 52.0 bits (123), Expect = 1e-05
Identities = 87/345 (25%), Positives = 123/345 (35%), Gaps = 62/345 (17%)
Query: 141 CQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTP-LSCQNGGTCVNTMGSYSC 199
C NG CLN + C+C P G A +CE + L+C+NG CVNT GS+ C
Sbjct: 1497 CPNG-RCLNTVPGYVCLCNP---GFHYDASHKKCEDHDECQDLACENG-ECVNTEGSFHC 1551
Query: 200 HC-PPETYGPQCASKYDDCEGGSVARCVHGIC--EDLMREQAGEPKYSCVCDAGWMFSPN 256
C PP T S RC++ EDL P + D W N
Sbjct: 1552 FCSPPLTLDL------------SQQRCMNSTSSTEDL-------PDHDIHMDICWKKVTN 1592
Query: 257 SPACTLDRDECSFQP--GPCSTLVQCFNTQGSFY---CGACPT-GWQGNGYICEDINECE 310
D CS +P G +T +C G + C CP + +C
Sbjct: 1593 --------DVCS-EPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEA 1643
Query: 311 INNGGCSVAPPVECVNTPGSSHCQACPPG----YQGDGRVCTLTDICSVSNGGCHPDASC 366
G P E P H P Y G T+ + + G D +
Sbjct: 1644 EREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRT- 1702
Query: 367 SSTLGSLPLCTCLPGYTGNGYGPNGC---VQLSNICLSHPCLNGQCIDTVSGYFCKCDSG 423
L P Y + P +Q + + C NG+C+ GY C C G
Sbjct: 1703 PILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEG 1762
Query: 424 W----TGVNCTENINEC--LSNP---CLNGGTCVDGVDSFSCECT 459
+ + C + +NEC L+ P C++ G C + S+ C C+
Sbjct: 1763 FQLDAAHMACVD-VNECDDLNGPAVLCVH-GYCENTEGSYRCHCS 1805
Score = 43.5 bits (101), Expect = 0.004
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 18/95 (18%)
Query: 173 ECEIYSGTPLSCQNGGTCVNTMGSYSCHC----PPETYGPQCA--SKYDDCEGGSVARCV 226
EC I +G C+NG CV Y+C C + C ++ DD G +V CV
Sbjct: 1736 ECGILNG----CENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL-CV 1789
Query: 227 HGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACT 261
HG CE+ E Y C C G++ P CT
Sbjct: 1790 HGYCENT------EGSYRCHCSPGYVAEAGPPHCT 1818
Score = 38.5 bits (88), Expect = 0.12
Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 6/81 (7%)
Query: 262 LDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG--YICEDINECEINNGGCSVA 319
L +EC G C +C + + C C G+Q + C D+NEC+ NG +
Sbjct: 1732 LQAEECGILNG-CEN-GRCVRVREGYTCD-CFEGFQLDAAHMACVDVNECDDLNGPAVLC 1788
Query: 320 PPVECVNTPGSSHCQACPPGY 340
C NT GS C C PGY
Sbjct: 1789 VHGYCENTEGSYRCH-CSPGY 1808
Score = 36.6 bits (83), Expect = 0.46
Identities = 25/53 (47%), Positives = 29/53 (54%), Gaps = 6/53 (11%)
Query: 292 CPTGWQG-NGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGD 343
CP G++ N C+DINEC + G C A ECVNT GS C C PG D
Sbjct: 608 CPQGYKRLNLTHCQDINEC-LTLGLCKDA---ECVNTRGSYLC-TCRPGLMLD 655
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 145 bits (367), Expect = 5e-34
Identities = 85/246 (34%), Positives = 124/246 (50%), Gaps = 13/246 (5%)
Query: 1613 RAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT-HFELER 1671
R Q CGG + + ++SP +P +YP++QNC WI+ A P I L+F HFE+E+
Sbjct: 21 RGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK 80
Query: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF---H 1728
C DF+EI DG E A L G++CG P I S S L ++F SD + GF +
Sbjct: 81 H-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 1729 TTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDS 1788
C F G SPG+P+ YP N++C + I++ P + L F+ F LE
Sbjct: 140 EIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHD 199
Query: 1789 Q------DCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGT 1841
DC D+++I +G G L+G+YCG P S G L + F +D + +
Sbjct: 200 PLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTG-ILSLTFHTDMAVAKD 258
Query: 1842 GFQATF 1847
GF A +
Sbjct: 259 GFSARY 264
Score = 137 bits (346), Expect = 1e-31
Identities = 81/243 (33%), Positives = 124/243 (51%), Gaps = 20/243 (8%)
Query: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAP-PETRIQLQFEDRFDIEVTPNC 2275
CGG + DA GY+TSP +P +YP H +C WI+ AP P +I L F F+IE +C
Sbjct: 28 CGGRLNSKDA---GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-KHDC 83
Query: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI-- 2333
+++E+RDG A +L K CG P + SSG ++Y++F SD + GF +Y I
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
Query: 2334 ---AQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQN---- 2386
C +G +ES G P Y NL C + + + + F F+L++
Sbjct: 144 TGSEDCSKNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQ 202
Query: 2387 --SSGCEKDFVEIWDN--HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFR 2442
C+ D+++IWD H G ++G+YCG P + +S+ + F TD +V GF
Sbjct: 203 VGEGDCKYDWLDIWDGIPHV-GPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFS 261
Query: 2443 LRF 2445
R+
Sbjct: 262 ARY 264
Score = 136 bits (342), Expect = 4e-31
Identities = 80/245 (32%), Positives = 126/245 (51%), Gaps = 19/245 (7%)
Query: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDV----NCFWVIKT-EMGKVLRITFT-FFRLES 523
P CG L+ + + SP GY D NC W++ E + + + F F +E
Sbjct: 24 PDPPCGGRLNSKDAGY-ITSP--GYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK 80
Query: 524 MDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRW 583
D C ++F+++ DGDS SA LG+ CG+ P ++SS + LY S++ R G GF++R+
Sbjct: 81 HD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Query: 584 E---TQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEH- 639
E T +C T P G+I+SPG+P YP DC + ++ P + + F LEH
Sbjct: 140 EIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHD 199
Query: 640 -----HDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQG 694
DC D+L+I DG + PL+GK+C T + L+++ + FH+D ++ G
Sbjct: 200 PLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDG 259
Query: 695 FHITY 699
F Y
Sbjct: 260 FSARY 264
Score = 134 bits (337), Expect = 2e-30
Identities = 83/251 (33%), Positives = 129/251 (51%), Gaps = 25/251 (9%)
Query: 2092 CGGYLHA-DRGIITSPKYPETYPSNLNCSWHVLV-QSGLTIAVHFEQPFQIPNGDSSCNQ 2149
CGG L++ D G ITSP YP+ YPS+ NC W V + I ++F F+I D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY-- 85
Query: 2150 GDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209
D++ +R+G + LG CG+ A T+ +S + ++++F SD++ +G GF ++
Sbjct: 86 -DFIEIRDGDSESADLLGK------HCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLR 138
Query: 2210 YE---AKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDR 2266
YE S C N G + SP P YP + DC + + A P+ I LQF
Sbjct: 139 YEIFKTGSEDCSKNF----TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFL-I 193
Query: 2267 FDIEVTP------NCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDN 2320
FD+E P +C ++L++ DG+ P++ K+CGT PS SS ++ L F +D
Sbjct: 194 FDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDM 253
Query: 2321 SPTHVGFKAKY 2331
+ GF A+Y
Sbjct: 254 AVAKDGFSARY 264
Score = 133 bits (335), Expect = 3e-30
Identities = 81/234 (34%), Positives = 121/234 (51%), Gaps = 11/234 (4%)
Query: 933 GEILTESTGTIQSPGHPNVYPHGINCTWHILV-QPNHLIHLMFET-FHLEFHYNCTNDYL 990
G + ++ G I SPG+P YP NC W + +PN I L F F +E H +C D++
Sbjct: 30 GRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYDFI 88
Query: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATA- 1047
E+ D DSE++ LG++CG PP++ SSG+ L + F +D GF + YE +
Sbjct: 89 EIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSED 148
Query: 1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEE-----AIGNY 1102
C +++T GT SP FP YP+N +C + I + I + F F LE G+
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 1103 YTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA 1156
D+L+I DG PL+G + G+ P + S + L L F +D + GFSA
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
Score = 129 bits (323), Expect = 7e-29
Identities = 78/239 (32%), Positives = 124/239 (51%), Gaps = 13/239 (5%)
Query: 2689 CGG-IQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQ-GHTITLTFSD-FDIEPHTTCAWD 2745
CGG + D+G ITSP YP Y S +C ++ AP+ I L F+ F+IE H C +D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 2746 SVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF---YATWNTQT 2802
+ +R+G S + ++G++CGN P TI S + L + F SD++ QG GF Y + T +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
Query: 2803 LGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISF----DNNFLIPSGDG 2858
C F S NGTI SP +P+ +P N C++T + + + F + + G+G
Sbjct: 147 EDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEG 206
Query: 2859 QCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASF 2916
C+ ++ +W G V L+ CG P + + + + F + A A+ GFSA +
Sbjct: 207 DCKYDWLDIWDGIPHVG-PLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 128 bits (322), Expect = 9e-29
Identities = 82/240 (34%), Positives = 117/240 (48%), Gaps = 20/240 (8%)
Query: 817 CGDELTGE--GVIRSPFFPNVYPGERTCRWTIHQPQ-SQVILLNFTV-FEIGSSAHCETD 872
CG L + G I SP +P YP + C W ++ P+ +Q I+LNF FEI C+ D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI-EKHDCKYD 86
Query: 873 YVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFS-----A 927
++EI + K+CG P I S + LY+ F + + GF ++ +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
Query: 928 EDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEF------ 981
ED C + T GTI+SPG P YPH ++CT+ IL +P I L F F LE
Sbjct: 147 ED--CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 982 HYNCTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
+C D+L+++D +G+YCG P L SS L L F TD +A +GF Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (316), Expect = 4e-28
Identities = 79/231 (34%), Positives = 118/231 (51%), Gaps = 13/231 (5%)
Query: 1055 DLGTFTSPNFPNNYPNNWECIYRITV-RTGQLIAVHFT-NFSLEEAIGNYYTDFLEIRDG 1112
D G TSP +P +YP++ C + + Q I ++F +F +E+ Y DF+EIRDG
Sbjct: 36 DAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY--DFIEIRDG 93
Query: 1113 GYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG---CGGNL 1169
E + LLG G+ PPTIIS + L++KF SD +GFS ++ TG C N
Sbjct: 94 DSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNF 153
Query: 1170 TTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHP------NCTLDYL 1223
T+ +GT SP +P Y H+ +C + + + L+F F LEH P +C D+L
Sbjct: 154 TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWL 213
Query: 1224 AVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
++DG L+ + CG + P +RSS + + TD GF A Y
Sbjct: 214 DIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 121 bits (304), Expect = 1e-26
Identities = 84/244 (34%), Positives = 125/244 (51%), Gaps = 22/244 (9%)
Query: 1738 CGGTFYMAE-GIFNSPGYPDIYPPNVECVWNIVS-SPGNRLQLSFISFQLEDSQDCSRDF 1795
CGG + G SPGYP YP + C W + + P ++ L+F + DC DF
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 1796 VEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFG-- 1852
+EIR+G++ + L+G++CGN P S G L+++F SD + G GF + +IF
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISS-GSMLYIKFTSDYARQGAGFSLRY-EIFKTG 145
Query: 1853 ----NDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQ----- 1903
+ N +G + SP +PE YPHN + +T+ + + L D+E
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGE 205
Query: 1904 -NCYYDKLRIYDGPSIHARLIGAYCGTQT--ESFSSTG-NSLTFHFYSDSSISGKGFLLE 1959
+C YD L I+DG LIG YCGT+T E SSTG SLTFH +D +++ GF
Sbjct: 206 GDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFH--TDMAVAKDGFSAR 263
Query: 1960 WFAV 1963
++ V
Sbjct: 264 YYLV 267
Score = 118 bits (296), Expect = 9e-26
Identities = 73/243 (30%), Positives = 119/243 (48%), Gaps = 8/243 (3%)
Query: 3037 CGGVFNFS-SGIITSPAYSYADYPNDMHCLYTITVSD-DKVIELKFSDFDVVPSTSCSHD 3094
CGG N +G ITSP Y DYP+ +C + + + ++ I L F+ + C +D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
Query: 3095 YLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQ 3154
++ I DG + S LLGK CG+ PP + SS + + + F +D + G+ + +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
Query: 3155 QGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTR-- 3212
+ C T N T SP Y NL+C + I+A I L F F LE +
Sbjct: 147 EDCSKNFTSPNGTIESPGFPEK--YPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 3213 -QRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
C YD++ ++DG L G +CG+ P+ SS L++ F +D+ + ++GF+A Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 3272 TIM 3274
++
Sbjct: 265 YLV 267
Score = 118 bits (296), Expect = 9e-26
Identities = 78/248 (31%), Positives = 124/248 (50%), Gaps = 26/248 (10%)
Query: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNIL---SLDIESHRTCAY 2034
CGG L + DA ++ SPG+P Y + +C W++ AP+ ++ + +IE H C Y
Sbjct: 28 CGGRLNSKDAG-YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKY 85
Query: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH----- 2089
D + IRDGD+ A L CG P I S+G ++I+FTSD + AGF+ +
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 2090 -KSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHF------EQPFQIPN 2142
+ C + G I SP +PE YP NL+C++ +L + + I + F P Q+
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGE 205
Query: 2143 GDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNE 2202
GD + D+L + +G P +GP G +CG+ S L +S + + F +D +
Sbjct: 206 GDC---KYDWLDIWDG----IPHVGPL--IGKYCGTKTPSELRSSTGILSLTFHTDMAVA 256
Query: 2203 GQGFKIKY 2210
GF +Y
Sbjct: 257 KDGFSARY 264
Score = 117 bits (294), Expect = 2e-25
Identities = 67/227 (29%), Positives = 113/227 (49%), Gaps = 11/227 (4%)
Query: 3401 KAFGNLRSPGWPDNYDNDKDCTVTLTAPQ-NHTISLFFHSLGIENSVECRNDFLEVRNGS 3459
K G + SPG+P +Y + ++C + AP+ N I L F+ +C+ DF+E+R+G
Sbjct: 35 KDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGD 94
Query: 3460 NSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEI---IWTSSPSGCGGTLY 3516
+ ++ LLGK+CG + P + S + LY++F SD G+ + I+ + C
Sbjct: 95 SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFT 154
Query: 3517 GDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISID-DP-----GDCVQNYLT 3570
G+ SPG+P YP+N C + ++A + + F ++ DP GDC ++L
Sbjct: 155 SPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLD 214
Query: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
++DG P G YCG T + +S+ + + FH D A F
Sbjct: 215 IWDGIPHVGPLIGKYCGTKTP-SELRSSTGILSLTFHTDMAVAKDGF 260
Score = 112 bits (279), Expect = 9e-24
Identities = 81/265 (30%), Positives = 117/265 (44%), Gaps = 26/265 (9%)
Query: 563 ALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGP-YGSIKSPGYPGNYPPGRDCVWIV- 620
ALYF S H G+ P CGG L G I SPGYP +YP ++C WIV
Sbjct: 12 ALYF---SRHQVRGQ--------PDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
Query: 621 VTSPDLLVTFTFGT-LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPF 679
P+ + F +E H DC D++EIRDG LLGK C + P + ++G
Sbjct: 61 APEPNQKIVLNFNPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSM 119
Query: 680 ARIHFHSDSQISDQGFHITY-LTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMM 738
I F SD GF + Y + C N+T P G + P + H C + +
Sbjct: 120 LYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTI 179
Query: 739 KQPQGEQIQINFTHVELQ------CQSDSSQNYIEVRDG----ETLLGKVCGNGTISHIK 788
+I + F +L+ + D +++++ DG L+GK CG T S ++
Sbjct: 180 LAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELR 239
Query: 789 SITNSVWIRFKIDASVEKASFRAVY 813
S T + + F D +V K F A Y
Sbjct: 240 SSTGILSLTFHTDMAVAKDGFSARY 264
Score = 111 bits (278), Expect = 1e-23
Identities = 75/255 (29%), Positives = 122/255 (47%), Gaps = 15/255 (5%)
Query: 2805 CGGIFHS-DNGTIRSPHWPQNFPENSRCSWTAITHK-SKHLEISFDNNFLIPSGDGQCQN 2862
CGG +S D G I SP +PQ++P + C W + ++ + ++F+ +F I D C+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD--CKY 85
Query: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFV---- 2917
F+++ G E LL CGN+AP +I+ + F S A GFS +
Sbjct: 86 DFIEIRDGDSE-SADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 2918 --SRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLE--ARSAV 2973
C NFT P+G I SP +P++Y +N++CT+ I A P ++L F+ F LE
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 2974 TGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKFSY 3032
G C D + I G + CG + P+ L + G + L F+++ + GF Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 3033 RIISCGGVFNFSSGI 3047
++ + NF +
Sbjct: 265 YLVHQEPLENFQCNV 279
Score = 111 bits (277), Expect = 1e-23
Identities = 76/244 (31%), Positives = 116/244 (47%), Gaps = 25/244 (10%)
Query: 1165 CGGNLTTSSGTFI-SPNYPMPYYHSSECYWWLKSSH-GSAFELEFKD-FHLEHHPNCTLD 1221
CGG L + +I SP YP Y C W + + L F F +E H +C D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYD 86
Query: 1222 YLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR------ 1275
++ + DG S ++ LL + CG+ PP I SSG ++IK +D +QG GF Y
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
Query: 1276 QTC-ENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEH----- 1329
+ C +N N G +ES G+P Y N C +TI A + FL FDLEH
Sbjct: 147 EDCSKNFTSPN---GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
Query: 1330 -HINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQM 1384
+C D+L+++DG +G+YCG P +++ L + TD + + GF
Sbjct: 204 GEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTD-MAVAKDGFSA 262
Query: 1385 QWFV 1388
++++
Sbjct: 263 RYYL 266
Score = 109 bits (272), Expect = 6e-23
Identities = 71/244 (29%), Positives = 115/244 (47%), Gaps = 16/244 (6%)
Query: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626
D CGG L + G TSPGY ++Y + NCEW + P + N I ++F +
Sbjct: 25 DPPCGGRLNSKDAGYITSPGYP--QDYPSHQNCEWIVYAP-EPNQKIVLNFNPHFEIEKH 81
Query: 2627 DCQFDVLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYS 2685
DC++D +E R GD++ L+ + CG P ++ S ++I F ++ + GF +Y
Sbjct: 82 DCKYDFIEIRDGDSESADLLGKHCGNIAPPT-IISSGSMLYIKFTSDYARQGAGFSLRYE 140
Query: 2686 F-----TDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIE--- 2737
DC +G I SP +P Y C+ + A I L F FD+E
Sbjct: 141 IFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDP 200
Query: 2738 ---PHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF 2794
C +D + + +G P+IG+YCG P ++S + L +TF++D ++ GF
Sbjct: 201 LQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGF 260
Query: 2795 YATW 2798
A +
Sbjct: 261 SARY 264
Score = 108 bits (270), Expect = 1e-22
Identities = 67/236 (28%), Positives = 117/236 (49%), Gaps = 24/236 (10%)
Query: 1289 GILESIGYPNPYSENQHCNWTIRATTGN---TVNYTFLAFDLEHHINCSTDYLELYDGPR 1345
G + S GYP Y +Q+C W + A N +N+ F++E H +C D++E+ DG
Sbjct: 38 GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFN-PHFEIEKH-DCKYDFIEIRDGDS 95
Query: 1346 Q----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGE-----LS 1396
+ +G++CG ++ PP +S + + T R+ GF +++ ++ G E +
Sbjct: 96 ESADLLGKHCG-NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFT 154
Query: 1397 GATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY------HSRCNFDVLE 1450
G+ SPGFP +YP N +C + I P I L FD+E+ C +D L+
Sbjct: 155 SPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLD 214
Query: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAV 1506
I+ G P I + C ++P ++ S+ L++ F TD+++ GF+A + V
Sbjct: 215 IWDGIPHVGPLIGKYCGTKTPS---ELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Score = 102 bits (253), Expect = 9e-21
Identities = 65/239 (27%), Positives = 112/239 (46%), Gaps = 16/239 (6%)
Query: 3275 DMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSP-PHQQVKITVWA-LQLTSQDC 3332
D PCGG N+ I+SP C W++ +P P+Q++ + ++ DC
Sbjct: 25 DPPCGGRLNSK-DAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDC 83
Query: 3333 TQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQI 3392
++++++D + + CG A P SS S + F S + + S Y+I
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAP--PTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
Query: 3393 -----ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSV- 3446
DC++++ G + SPG+P+ Y ++ DCT T+ A I L F +E+
Sbjct: 142 FKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPL 201
Query: 3447 -----ECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY 3500
+C+ D+L++ +G PL+GKYCGT P+ + S L L F +D + G+
Sbjct: 202 QVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGF 260
Score = 100 bits (249), Expect = 3e-20
Identities = 68/239 (28%), Positives = 114/239 (47%), Gaps = 14/239 (5%)
Query: 2336 CGGRVPGQ-SGVVESIGHPTLPYRDNLFCEWHLQGLSGHY-LTISFEDFNLQNSSGCEKD 2393
CGGR+ + +G + S G+P Y + CEW + + + ++F C+ D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
Query: 2394 FVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFE---SSM 2449
F+EI D + S ++LG++CGN P +I +S + ++F +D + +GF LR+E +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
Query: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHP------ 2503
E+C + GT SP +P PH C + I A I L F L P
Sbjct: 147 EDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEG 206
Query: 2504 SCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
C + + +++GI P + K C + +E++SS + + F TD + GF+A Y
Sbjct: 207 DCKYDWLDIWDGIPHVGPLIGKYCGT-KTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 99.0 bits (245), Expect = 8e-20
Identities = 68/242 (28%), Positives = 113/242 (46%), Gaps = 21/242 (8%)
Query: 1391 CGGELSGA-TGSFSSPGFPNRYPPNKECIWYIRT-DPGSSIQLTIHD-FDVEYHSRCNFD 1447
CGG L+ G +SPG+P YP ++ C W + +P I L + F++E H C +D
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507
+EI G + + + C +P + S+G+ L I+F +D + G GF+ ++
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPT---IISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
Query: 1508 GG---CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE------ 1558
G C F +P+G I SP +P Y N DC++ I ++L F FDLE
Sbjct: 144 TGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
Query: 1559 PQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRA 1614
+ C + +DG+ + + CG + + + SS L L F + + GF A
Sbjct: 204 GEGDCKYDWLDIWDGIPHVGPLIGKYCG-TKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
Query: 1615 QF 1616
++
Sbjct: 263 RY 264
Score = 95.9 bits (237), Expect = 6e-19
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 25/241 (10%)
Query: 1861 GKVASPFWPENYPHNSNYQWTVNVNASH--VVHGRILEMDIEEIQNCYYDKLRIYDGPSI 1918
G + SP +P++YP + N +W V + +V +IE+ +C YD + I DG S
Sbjct: 38 GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96
Query: 1919 HARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEW--FAVDAPDGVLPTIAP 1975
A L+G +CG + S+G+ L F SD + G GF L + F + D +P
Sbjct: 97 SADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSP 156
Query: 1976 GACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIE------S 2028
+ SPG+P+ Y + +DCT+ I A P + L L D+E
Sbjct: 157 NGT------------IESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 2029 HRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
C YD L I DG ++ + CG + P +RS+ + + F +D +V + GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 2089 H 2089
+
Sbjct: 265 Y 265
Score = 91.7 bits (226), Expect = 1e-17
Identities = 70/241 (29%), Positives = 109/241 (45%), Gaps = 21/241 (8%)
Query: 705 DLRCGGNYTDPE-GELFLPELSGPFTHTRQCVYMMKQPQGEQ-IQINFT-HVELQCQSDS 761
D CGG + G + P + + C +++ P+ Q I +NF H E++ + D
Sbjct: 25 DPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-KHDC 83
Query: 762 SQNYIEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV-- 815
++IE+RDG++ LLGK CGN I S + ++I+F D + + A F Y++
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
Query: 816 ----ACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG------ 864
C T G I SP FP YP C +TI I+L F +F++
Sbjct: 144 TGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
Query: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
C+ D+++I P KYCGT PS + S L +TF + GF A+
Sbjct: 204 GEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSAR 263
Query: 925 F 925
+
Sbjct: 264 Y 264
Score = 89.0 bits (219), Expect = 8e-17
Identities = 72/248 (29%), Positives = 113/248 (45%), Gaps = 34/248 (13%)
Query: 3153 PQQGCGGYLTGSNNTF-ASPDSDSNGMYDKNLNCVWIIIAPV-NKVIHLTFNT-FALEAA 3209
P CGG L + + SP + Y + NC WI+ AP N+ I L FN F +E
Sbjct: 24 PDPPCGGRLNSKDAGYITSPGYPQD--YPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-- 79
Query: 3210 STRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269
+ C YD++++ DGDSE+A+L G CG+ P ISSG+ L ++F SD + GF+
Sbjct: 80 --KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSL 137
Query: 3270 TYTIMDMPCGGTYNATWTPQNISSPNSS--DPDVPFSI-----CTWVIDSPPHQQVKITV 3322
Y I G+ + + +N +SPN + P P CT+ I + P ++ +
Sbjct: 138 RYEIFKT---GSEDCS---KNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQF 191
Query: 3323 W-------ALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNA-----SAVPVFYSSMST 3370
LQ+ DC ++L + D G ++CG S+ + + T
Sbjct: 192 LIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHT 251
Query: 3371 AMVIFKSG 3378
M + K G
Sbjct: 252 DMAVAKDG 259
Score = 77.4 bits (189), Expect = 2e-13
Identities = 42/116 (36%), Positives = 68/116 (58%), Gaps = 7/116 (6%)
Query: 3511 CGGTLYG-DRGSFTSPGYPGTYPNNTYCEWVLVAPA-GRLVTINFYFISIDDPGDCVQNY 3568
CGG L D G TSPGYP YP++ CEW++ AP + + +NF + DC ++
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 3569 LTLYDGPNASSPSSGPYCGGDTSIAP--FVASSNQVFIKFHADYARRPSAFRLTWD 3622
+ + DG + S+ G +CG +IAP ++S + ++IKF +DYAR+ + F L ++
Sbjct: 88 IEIRDGDSESADLLGKHCG---NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 164,257,927
Number of Sequences: 37866
Number of extensions: 8433329
Number of successful extensions: 32147
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 215
Number of HSP's successfully gapped in prelim test: 216
Number of HSP's that attempted gapping in prelim test: 15677
Number of HSP's gapped (non-prelim): 7277
length of query: 3623
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3501
effective length of database: 13,627,866
effective search space: 47711158866
effective search space used: 47711158866
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.