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Search of human proteins with 126012562
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126012562 low density lipoprotein-related protein 1 [Homo
sapiens]
(4544 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 9837 0.0
gi|93102379 low density lipoprotein-related protein 1B precursor... 6070 0.0
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 2860 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 1121 0.0
gi|148727288 low density lipoprotein receptor-related protein 6 ... 816 0.0
gi|119709832 low density lipoprotein receptor-related protein 5 ... 810 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 538 e-152
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 538 e-152
gi|61744471 low density lipoprotein receptor-related protein 8 i... 518 e-146
gi|65301119 low density lipoprotein receptor-related protein 8 i... 518 e-146
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 503 e-141
gi|4507157 sortilin-related receptor containing LDLR class A rep... 472 e-132
gi|61744467 low density lipoprotein receptor-related protein 8 i... 415 e-115
gi|66082554 low density lipoprotein receptor-related protein 8 i... 400 e-110
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 271 1e-71
gi|29244926 corin [Homo sapiens] 203 4e-51
gi|134031945 SCO-spondin [Homo sapiens] 191 1e-47
gi|115298674 nidogen 1 precursor [Homo sapiens] 179 7e-44
gi|32698824 low density lipoprotein receptor-related protein 5-l... 176 5e-43
gi|209447022 low density lipoprotein receptor-related protein 5-... 176 5e-43
gi|144953895 nidogen 2 precursor [Homo sapiens] 156 5e-37
gi|11415040 matriptase [Homo sapiens] 138 1e-31
gi|55770876 notch4 preproprotein [Homo sapiens] 134 2e-30
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 132 8e-30
gi|24041035 notch 2 preproprotein [Homo sapiens] 127 3e-28
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 120 4e-26
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 116 4e-25
gi|28557796 low density lipoprotein receptor class A domain cont... 115 1e-24
gi|134244285 Notch homolog 3 [Homo sapiens] 112 1e-23
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens] 112 1e-23
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 9837 bits (25527), Expect = 0.0
Identities = 4544/4544 (100%), Positives = 4544/4544 (100%)
Query: 1 MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA 60
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA
Sbjct: 1 MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA 60
Query: 61 PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC 120
PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC
Sbjct: 61 PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC 120
Query: 121 QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL 180
QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
Sbjct: 121 QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL 180
Query: 181 LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE 240
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE
Sbjct: 181 LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE 240
Query: 241 TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI 300
TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI
Sbjct: 241 TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI 300
Query: 301 DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK 360
DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK
Sbjct: 301 DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK 360
Query: 361 LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE 420
LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE
Sbjct: 361 LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE 420
Query: 421 NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN 480
NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN
Sbjct: 421 NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN 480
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG 600
MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG 600
Query: 601 IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG 660
IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG
Sbjct: 601 IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG 660
Query: 661 WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY 720
WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY
Sbjct: 661 WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY 720
Query: 721 DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT 780
DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT
Sbjct: 721 DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT 780
Query: 781 LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV 840
LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV
Sbjct: 781 LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV 840
Query: 841 TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF 900
TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF
Sbjct: 841 TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF 900
Query: 901 KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD
Sbjct: 901 KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
Query: 961 CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF 1020
CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF
Sbjct: 961 CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF 1020
Query: 1021 KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW 1080
KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW
Sbjct: 1021 KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW 1080
Query: 1081 RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC
Sbjct: 1081 RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
Query: 1141 ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP 1200
ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP
Sbjct: 1141 ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP 1200
Query: 1201 GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES 1260
GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES
Sbjct: 1201 GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES 1260
Query: 1261 CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK 1320
CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK
Sbjct: 1261 CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK 1320
Query: 1321 IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT 1380
IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT
Sbjct: 1321 IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT 1380
Query: 1381 LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT 1440
LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT
Sbjct: 1381 LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT 1440
Query: 1441 VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT 1500
VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT
Sbjct: 1441 VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT 1500
Query: 1501 LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT 1560
LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT
Sbjct: 1501 LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT 1560
Query: 1561 VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL 1620
VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL
Sbjct: 1561 VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL 1620
Query: 1621 DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN 1680
DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN
Sbjct: 1621 DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN 1680
Query: 1681 KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG 1740
KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG
Sbjct: 1681 KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG 1740
Query: 1741 QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800
QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW
Sbjct: 1741 QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800
Query: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL 1860
WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL
Sbjct: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL 1860
Query: 1861 CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG 1920
CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG
Sbjct: 1861 CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG 1920
Query: 1921 TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY 1980
TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY
Sbjct: 1921 TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY 1980
Query: 1981 WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG 2040
WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG
Sbjct: 1981 WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG 2040
Query: 2041 TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS 2100
TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS
Sbjct: 2041 TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS 2100
Query: 2101 VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA 2160
VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA
Sbjct: 2101 VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA 2160
Query: 2161 VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL 2220
VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL
Sbjct: 2161 VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL 2220
Query: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE 2280
NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE
Sbjct: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE 2280
Query: 2281 NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD 2340
NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD
Sbjct: 2281 NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD 2340
Query: 2341 ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK 2400
ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK
Sbjct: 2341 ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK 2400
Query: 2401 IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI 2460
IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI
Sbjct: 2401 IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI 2460
Query: 2461 PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV 2520
PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV
Sbjct: 2461 PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV 2520
Query: 2521 NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS 2580
NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS
Sbjct: 2521 NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS 2580
Query: 2581 NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS
Sbjct: 2581 NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
Query: 2641 ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY 2700
ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY
Sbjct: 2641 ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY 2700
Query: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG
Sbjct: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
Query: 2761 DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD 2820
DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD
Sbjct: 2761 DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD 2820
Query: 2821 REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG 2880
REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG
Sbjct: 2821 REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG 2880
Query: 2881 ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH 2940
ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH
Sbjct: 2881 ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH 2940
Query: 2941 INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH 3000
INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH
Sbjct: 2941 INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH 3000
Query: 3001 GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV 3060
GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV
Sbjct: 3001 GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV 3060
Query: 3061 ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD 3120
ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD
Sbjct: 3061 ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD 3120
Query: 3121 KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR 3180
KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR
Sbjct: 3121 KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR 3180
Query: 3181 SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF 3240
SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF
Sbjct: 3181 SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF 3240
Query: 3241 EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG 3300
EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG
Sbjct: 3241 EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG 3300
Query: 3301 CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG 3360
CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG
Sbjct: 3301 CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG 3360
Query: 3361 DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 3420
DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC
Sbjct: 3361 DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC 3420
Query: 3421 TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV 3480
TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV
Sbjct: 3421 TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV 3480
Query: 3481 DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ 3540
DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ
Sbjct: 3481 DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ 3540
Query: 3541 FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC 3600
FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC
Sbjct: 3541 FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC 3600
Query: 3601 ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ 3660
ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ
Sbjct: 3601 ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ 3660
Query: 3661 CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD 3720
CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD
Sbjct: 3661 CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD 3720
Query: 3721 NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP 3780
NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP
Sbjct: 3721 NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP 3780
Query: 3781 KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN 3840
KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN
Sbjct: 3781 KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN 3840
Query: 3841 TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV 3900
TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV
Sbjct: 3841 TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV 3900
Query: 3901 RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP 3960
RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP
Sbjct: 3901 RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP 3960
Query: 3961 RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4020
RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW
Sbjct: 3961 RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4020
Query: 4021 GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI 4080
GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI
Sbjct: 4021 GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI 4080
Query: 4081 VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH 4140
VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH
Sbjct: 4081 VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH 4140
Query: 4141 QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC 4200
QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC
Sbjct: 4141 QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC 4200
Query: 4201 NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT 4260
NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT
Sbjct: 4201 NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT 4260
Query: 4261 GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM 4320
GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM
Sbjct: 4261 GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM 4320
Query: 4321 AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH 4380
AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH
Sbjct: 4321 AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH 4380
Query: 4381 CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV 4440
CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV
Sbjct: 4381 CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV 4440
Query: 4441 VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT 4500
VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT
Sbjct: 4441 VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT 4500
Query: 4501 NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA 4544
NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
Sbjct: 4501 NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA 4544
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 6070 bits (15748), Expect = 0.0
Identities = 2772/4639 (59%), Positives = 3423/4639 (73%), Gaps = 156/4639 (3%)
Query: 9 LLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSK 68
LLP+ L A + C P +F C D +TC+S+ W CDG+ DCPD SDE+ + CP+
Sbjct: 14 LLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEV 73
Query: 69 AQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTL 128
+C N CLGT CV +S+LCNGV DC DG DEG HC+EL NC +L CQ+ C
Sbjct: 74 EIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVR 133
Query: 129 DGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSC 188
+ CYC F++ DG++CKD DEC+VYGTCSQ C NT GS+ C CVEGYL+QPDNRSC
Sbjct: 134 NSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
Query: 189 KAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVG 248
KAK EP DRPP+LLIAN + I YL+G++++T++ + + +DF Y + +CW+
Sbjct: 194 KAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESR 253
Query: 249 DSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCN 308
+S+ QLKC ++ G DE TINI S H+V+QMAIDWLT N YFVD + DRIFVCN
Sbjct: 254 ESS--NQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCN 311
Query: 309 RNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVF 368
NG CVTL+DLEL+NPK IA+DP GK+FFTDYG + KVERCDMDG NRT+++DSK
Sbjct: 312 SNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQ 371
Query: 369 PHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNS 428
P + LDLV++LVYW D YLDY+ VVDY+GK R T+IQG + HLYG+TVFE+YLYATNS
Sbjct: 372 PAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNS 431
Query: 429 DNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGG 488
DN N ++R+NRFN T+ + +++ + IY +R QP VRSHACE D YG PGG
Sbjct: 432 DNYN------IVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGG 485
Query: 489 CSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVP 548
CS ICLL++S+K RTCRCR+GF+LGSDG+SCK+P++ELFL YGKGRPGI+RGMD+ K+
Sbjct: 486 CSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIA 545
Query: 549 DEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVA 608
DE+MIPIENL+NPRALDFHAET +IYFADTTS+LIGRQKIDGTERETILKD + NVEG+A
Sbjct: 546 DEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIA 605
Query: 609 VDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
VDW+G+NLYWT+DG +KTI+VARLEKA+Q+RKTL+EG+M+HPR IVVDP+NGWMYWTDWE
Sbjct: 606 VDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWE 665
Query: 669 EDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILL 728
ED D GR+E+AWMDG +R IFVTSK +LWPNGL+LD LYW DA+YD IE + L
Sbjct: 666 EDEIDDSVGRIEKAWMDGFNRQIFVTSK-MLWPNGLTLDFHTNTLYWCDAYYDHIEKVFL 724
Query: 729 NGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPP 788
NGT RKIVY G ELNH FGL HHGNY+FWT+Y +GS+++L+ VTLLR ERPP
Sbjct: 725 NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDL----ITSEVTLLRHERPP 780
Query: 789 IFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSY 848
+F +++YD ++QQ G N CRVNNGGCS+LCLA PG R CACA++Q+LD +G TC NP
Sbjct: 781 LFGLQIYDPRKQQ-GDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGE 839
Query: 849 VPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCI 908
P C+ GEF C N CIQ RWKCDGD+DCLD SDE C H+CP D+FKC+NNRCI
Sbjct: 840 ALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCI 899
Query: 909 PNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDES 968
P RWLCDG NDCG++EDESN TC+ARTC +QFSC +GRCIP +W CD +DDCGD++DE
Sbjct: 900 PKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEM 959
Query: 969 ASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCI 1028
ASC +PTC PLTQF C +GRCI+ W CD+D+DCGD SDE GC HSC QF+C+SGRCI
Sbjct: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
Query: 1029 PEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDC 1088
P HW CDGDNDCGD+SDE NCT + P GC+ +EFQC DG C+P WRCDG+ DC
Sbjct: 1020 PGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDC 1079
Query: 1089 MDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPP 1148
D SDEK C G +CD KF C + RCI+KAWVCDGD DCED SDE++C+S C PP
Sbjct: 1080 EDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPP 1139
Query: 1149 SHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSC 1208
HPCAN+TSVCL P+KLC+G DC DGSDEG LCD+CSLNNGGCS++CSV PG GIVCSC
Sbjct: 1140 KHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSC 1199
Query: 1209 PLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFK 1268
P G++L DN TC+I YC+ HLKCSQ C+Q+K +VKCSCYEGW L+ DGESC S+DPF+
Sbjct: 1200 PEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFE 1259
Query: 1269 PFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLD 1328
FIIFS RHEIRRIDLHK DYS+LVPGLRNTIALDFH +QS LYWTDVVED+IYRGKL +
Sbjct: 1260 AFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319
Query: 1329 NGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEH 1388
+G +++ EVV+++GLATPEGL VDWIAGNIYW++SNLDQIEVAKLDG+LRTTL+AG +EH
Sbjct: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEH 1379
Query: 1389 PRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRI 1448
PRAIALDPR GILFWTDWDA+ PRIE+ASMSGAGR+T++++ +G WPNGLTVD+ EKRI
Sbjct: 1380 PRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRI 1439
Query: 1449 LWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWT 1508
+W DARSDAIYSA YDG+ +E++RGHE+LSHPFAV+LYG EVYWTDWRTNTL+KANKWT
Sbjct: 1440 VWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWT 1499
Query: 1509 GHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHL 1568
G NV+V+Q+T+ QPFDLQ+YHPSRQP APNPC AN G+GPCSH+CLIN+NR+ +CACPHL
Sbjct: 1500 GQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHL 1559
Query: 1569 MKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQR 1628
MKL D TCYE KKFLLYAR+ EIRGVD+D PY+N+I +FTVPDID+VTV+D+DA E+R
Sbjct: 1560 MKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEER 1619
Query: 1629 VYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVAR 1688
+YW+D++TQ IKRAFINGTG+ETV+S D+ + GLAVDWVSRNL+W S + ++ QINVAR
Sbjct: 1620 LYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVAR 1679
Query: 1689 LDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLA 1748
LDGS K +++ G+++P L HP+RGKLYWTDG+ I+MANMDGSN +LF QK PVGL+
Sbjct: 1680 LDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLS 1739
Query: 1749 IDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEK 1808
ID+ E+KLYWISSGN TINRCNLDG LEVI++M+ +L KATAL IM KLWWADQ +
Sbjct: 1740 IDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQ 1799
Query: 1809 MGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETT 1868
+GTCSK DG +LRN T+ V+HMKVYD+ Q +G+N C +NNG CSQLCLPTSETT
Sbjct: 1800 LGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQ---QGSNSCQLNNGGCSQLCLPTSETT 1856
Query: 1869 RSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGID 1928
R+CMCT GY L+ + +C+G+ SFL+YSVHEGIRGIPL+P+DK DAL+P+SGTS AVGID
Sbjct: 1857 RTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGID 1916
Query: 1929 FHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDV 1988
FHAENDTIYW DMG + ISRAKRDQTW+ED++TNG+GRVEGIAVDWIAGNIYWTD GF++
Sbjct: 1917 FHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNL 1976
Query: 1989 IEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048
IEVARLNGSFRYV+ISQGLD+PR+I VHPEKG LFWTEWGQ P I ++RLDG+E+VVLV+
Sbjct: 1977 IEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVS 2036
Query: 2049 VSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFI 2108
+ I+WPNGIS+DY++ KLYWCDARTDKIERIDLETG NRE+VLS +N+DMFSV+VF +I
Sbjct: 2037 MGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYI 2096
Query: 2109 YWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQ 2168
YWSDR HANGS++RG K++AT+++ +RTG+GV LK++K+FNR R+KGTNVCA NGGC+Q
Sbjct: 2097 YWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQ 2156
Query: 2169 LCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFE 2228
LCLYRG +R CACAHG LAEDG +C + GYLLYS RTILKSIHLSDE NLN+P++P+E
Sbjct: 2157 LCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYE 2216
Query: 2229 DPEHMKNVIALAFDY---RAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSV 2285
+P + KNVIALAFDY R GT NRIF+SD HFGNIQ I D+ R IVENVGSV
Sbjct: 2217 NPRYFKNVIALAFDYNQRRKGT-----NRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSV 2271
Query: 2286 EGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNL 2345
EGLAYHR WDTLYWTS TTS+ITRHTVDQTRPGAF+RE VITMS DDHP LDECQNL
Sbjct: 2272 EGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNL 2331
Query: 2346 MFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCE 2405
MFWTNWNEQHPSIMR+ L+G N ++ DI TPNGL ID+RAEKLYFSD +L KIERCE
Sbjct: 2332 MFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCE 2391
Query: 2406 YDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPM 2465
YDGS R+VI+KS P LAVY +IFW+DW RRA+ R+NK+ G + K+LR DIP QPM
Sbjct: 2392 YDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPM 2451
Query: 2466 GIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCR 2525
GIIAVANDTNSCELSPC + NGGC DLCLLT G VNCSCRG RIL +D C NSSC
Sbjct: 2452 GIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCN 2511
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
A EFEC NGECI++ LTCDG+PHCKDKSDEK YC +R C++ F+ C N RC+ + C
Sbjct: 2512 AYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLC 2571
Query: 2586 NGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCS 2645
+G +DCGD SDE+ C + C EFRC DGTCI S+RCNQ +DC DASDE NC+ TDC+
Sbjct: 2572 DGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT 2631
Query: 2646 SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPS 2705
+++LGVK F C TSLC P+W+CDG+NDCGDYSDE CP + +C NYF+CPS
Sbjct: 2632 HFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS 2691
Query: 2706 GRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
GRCI +W CD + DCE G DE HC+ CS QF C +CISK W+CDG DDCGDG DE
Sbjct: 2692 GRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
Query: 2766 A-AHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFM 2824
+ + C TC FSC G+ CVP WLCDG++DC DG+DE AGC N+TCD+ FM
Sbjct: 2752 SDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFM 2811
Query: 2825 CQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDC 2884
C N+ CIPK FVCDHD DC DGSDESP+C Y CG EF CA+GRCL + QW+CDG+ DC
Sbjct: 2812 CHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC 2871
Query: 2885 HDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINEC 2944
D SDEAP NP C S E CN SS F+C +GRC+ LC+ +DDCGD SDER CHINEC
Sbjct: 2872 PDHSDEAPLNPKCKSAEQSCN-SSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINEC 2930
Query: 2945 LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYK 3004
LS+K+SGCSQDC+DL + +KC+C PGF+LKDDG+TC D+DECS+ FPCSQ+CINT+G+YK
Sbjct: 2931 LSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYK 2990
Query: 3005 CLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDF 3064
CLC +GY + +P+ CK+++DEEPFLI A+ + +RK++ DGSNYTLLKQGLNN +A+DF
Sbjct: 2991 CLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDF 3050
Query: 3065 DYREQMIYWTDVTT-QGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGR 3123
DYRE+ IYW D + GS I RM LNGS+++V+H T + P+ LAVDW+G NLYW D +
Sbjct: 3051 DYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEK 3108
Query: 3124 DTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVI 3183
IEVSKLNG Y T+LVS L+ PR L +D Q GYLYW D ++ IGR+GMDG+++SV+
Sbjct: 3109 RIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVV 3168
Query: 3184 VDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDY 3243
++TKI+ P LT+DYV R+YWAD E++IEF+++DGS+RH V +QDIP + ALTLFEDY
Sbjct: 3169 IETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDY 3226
Query: 3244 VYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSN 3303
+YWTD +TKS++RAHKT+G ++ LI + H D+ V+H+ RQPDV H C +NNGGCS+
Sbjct: 3227 IYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSH 3286
Query: 3304 LCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHS 3363
LCLL+PG H CACPTNFYL +D RTC+SNCTASQF CK DKCIPFWWKCDT DDCGD S
Sbjct: 3287 LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGS 3346
Query: 3364 DEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNT 3423
DEP DCPEF+C+PG+FQC TG+C PAFICDG+NDC DNSDE NCD HVCL QFKCT
Sbjct: 3347 DEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKN 3406
Query: 3424 NRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGS 3483
+CIP RCNGQD+CGD EDERDCPE +C+P+ FQC TK CI ++WVCD D DC D S
Sbjct: 3407 QKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS 3466
Query: 3484 DEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC------------ 3531
DE ANC + TCG EF+CK++ CIP W+CD ++DC D SDE E C
Sbjct: 3467 DE-ANCDKKTCGPHEFQCKNNN-CIPDHWRCDSQNDCSDNSDE--ENCKPQTCTLKDFLC 3522
Query: 3532 ----------------------DERTCEPY----QFRCKNNRCVPGRWQCDYDNDCGDNS 3565
DER CE QFRC N +C+P +W+CD DC
Sbjct: 3523 ANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGE 3582
Query: 3566 DEESCTPRP--CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS- 3622
DE+SC P CS E+ CA+ CI+ KC+G++DCADGSDE DC C DQF+CK+
Sbjct: 3583 DEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNK 3642
Query: 3623 GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDN 3682
HCIP+RW CD DC+DGSDEE C G C DEF CNN+LCK W CDGEDDCGDN
Sbjct: 3643 AHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDN 3702
Query: 3683 SDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCK 3742
SDE P+ C +F+CP RP RC+N+R+CL + C+G D CGD +DE+ C +
Sbjct: 3703 SDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPC 3762
Query: 3743 DKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTE 3802
K EF C N++C+ L+C+ DDCGDGSDE+ C I P +C N + CGD+A C + +
Sbjct: 3763 KKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIK 3822
Query: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKA 3862
+ +C C+ GF C+D+NECL FGTCS C N +G + C C +NF + +NTC A
Sbjct: 3823 TSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIA 3882
Query: 3863 EGSEYQVLYIADDNEIRS-LFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYW-TNWH 3920
EGSE QVLYIA+D +I ++P + ++Q + + RI MDV+ + + W T ++
Sbjct: 3883 EGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFN 3942
Query: 3921 TGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTD---- 3976
G I Y+ + R +RQ + G L K PR IA+DWVAGN+YWTD
Sbjct: 3943 PGGIFYKRI--------HGREKRQANSG---LICPEFKRPRDIAVDWVAGNIYWTDHSRM 3991
Query: 3977 -----------SGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPK 4025
S R I V Q+ G N L++ M EP+AI V+P RG MYW+ G+H
Sbjct: 3992 HWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSH 4051
Query: 4026 IETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADS 4085
IE AAMDGTLR LVQ N+Q PTGLAVDY +ER+YWAD +LS+IGS+ +G++ +V+ S
Sbjct: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
Query: 4086 KRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQP 4145
K+GL HP ID+FEDYIYG N VF++ KFGH + L + V++ H++KQ
Sbjct: 4112 KQGLLHPHRIDIFEDYIYGAGP-KNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQL 4170
Query: 4146 EVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCF 4205
++ NPC CE+LCLL+PSG C CP GK L NGTC D+ +C L C
Sbjct: 4171 DLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTC--------NDDSLLDDSCKLTCE 4222
Query: 4206 NGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGP 4265
NGG C LN + +C C P Y+G++CE++ C +C+NGGTC S G PTC C GFTGP
Sbjct: 4223 NGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGP 4282
Query: 4266 KCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGS 4325
C + VC +C N TC V GNQP C C P + GDRCQY C YC N +C + DGS
Sbjct: 4283 NCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGS 4342
Query: 4326 RQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGG 4385
+C C +EG +CEV+KC RC G C++NK S D+ CNCT+G++A SC C G+C NGG
Sbjct: 4343 VECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGG 4402
Query: 4386 SCTMNSKM-MPECQCPPHMTGPRCEEHVFSQQQPGHIAS----ILIPLLLLLLLV--LVA 4438
+C ++ + +P C C + +G +CE + HI++ I++PL+LL+ L+ LV
Sbjct: 4403 TCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVI 4462
Query: 4439 GVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDK 4498
G+V ++R K + Q + NG +NVEIGNP+Y MYE + GGLLD F +DP K
Sbjct: 4463 GLVLCKRKR--RTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTK 4520
Query: 4499 ---------------------------------PTNFTNPVYATLYMGGHGSRHSLASTD 4525
PTN++NPVYA LYM G R+SL S D
Sbjct: 4521 ARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVD 4580
Query: 4526 EKRELLGRGPEDEIGDPLA 4544
E++ELL + E I + +A
Sbjct: 4581 ERKELLPKKIEIGIRETVA 4599
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 2860 bits (7414), Expect = 0.0
Identities = 1648/4344 (37%), Positives = 2335/4344 (53%), Gaps = 288/4344 (6%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
TC QF C CI + W CDGE DC D DE +C P E +C + C
Sbjct: 221 TCGGYQFTCPSG-RCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRC 279
Query: 86 VPMSRLCNGVQDCMDGSDE-----GPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
+ + ++C+G+ DC DE G +C CS L CQ+ C T G C+C +
Sbjct: 280 ISIYKVCDGILDCPGREDENNTSTGKYCSMTL--CSALNCQYQCHETPYGGACFCPPGYI 337
Query: 141 LQA-DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPP 199
+ D +TC +FD+C ++G C Q C + G +C C EGY+L+ + CKA + +
Sbjct: 338 INHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEAS- 395
Query: 200 VLLIANSQNILATYLSGAQVSTITPTSTRQTTA-MDFSYANETVCWVHVGDSAAQTQLKC 258
++ +N +++L + G + + R + F Y + V W Q ++
Sbjct: 396 -IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWT----DTVQNKVFS 450
Query: 259 ARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLL 318
+ GL + +N+S+ E +A+DW+ Y V+ +RI + N +G VTL+
Sbjct: 451 VDINGLN---IQEVLNVSVETP--ENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLI 505
Query: 319 DLELYNPKGIALDPAMGKVFFTDYGQI---PKVERCDMDGQNRTKLVDSKIVFPHGITLD 375
L +P+GIA+DP +G +FF+D+ + PK+ER MDG NR LV +K+ +P G+TLD
Sbjct: 506 TENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLD 565
Query: 376 LVSRLVYWADAYLDYIEVVDYEGKGRQTIIQG-ILIEHLYGLTVFENYLYATNSDNANAQ 434
++S+ VYW D+ DYIE V Y+G R+T++ G LI H +G+++FE ++ T+
Sbjct: 566 MISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTD------W 619
Query: 435 QKTSVIRVNRFNSTEYQVVTRVD-KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDIC 493
K +V++ N+F T QV + + + +YH RQP + +N+ GGC +C
Sbjct: 620 TKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNN-----GGCEQVC 674
Query: 494 LLA----NSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPD 549
+L+ N C+C GF L +D + C ++ FL++ IRG+ +
Sbjct: 675 VLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN--FLIFSS--QVAIRGIPFTLSTQE 730
Query: 550 EHMIPIENLMNPR---ALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEG 606
+ M+P+ NP +DF A+ I+F+D + ++I +QKIDGT RE + + + NVE
Sbjct: 731 DVMVPVSG--NPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVES 788
Query: 607 VAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTD 666
+A DW+ NLYWTD K+ISV RL A +TR+T+++ + +PR++VV P G++++TD
Sbjct: 789 LAFDWISKNLYWTDSH-YKSISVMRL--ADKTRRTVVQ-YLNNPRSVVVHPFAGYLFFTD 844
Query: 667 WEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETI 726
W R ++ RAW DGSH + V + T+ WPNGL++D A RLYWVDA++D+IE
Sbjct: 845 W------FRPAKIMRAWSDGSHL-LPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHS 897
Query: 727 LLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSER 786
+G DR+ + ++ H FGL G +LF+T++R G++ R+ + GG +T++RS
Sbjct: 898 TFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGE---MTVIRSGI 954
Query: 787 PPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATPG-SRQCACAEDQVLDADGVTC 842
I ++ YD Q G+N C NG CS C P R C C L ++ +TC
Sbjct: 955 AYILHLKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC 1013
Query: 843 LANPSYVPPP-QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFK 901
+P+ PP QC F C N RC+ + CDG +DC DNSDE +TC S F
Sbjct: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
Query: 902 CENNRCIPNRWLCDGDNDCGNSEDESNA-TCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
C + CIP W CD NDC + DE N T + +C Q++C + +CI +W CD D+D
Sbjct: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDND 1133
Query: 961 CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF 1020
CGD SDE + TC P +QF C N RCI++++ CD D DC D SDE GC +C+++QF
Sbjct: 1134 CGDGSDEKNCNSTETCQP-SQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQF 1192
Query: 1021 KCNSG-RCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
KC SG +CI CDG DC D SDE A C TRPPG CH+DEFQC+ DG+CIP
Sbjct: 1193 KCASGDKCIGVTNRCDGVFDCSDNSDE--AGCP---TRPPGMCHSDEFQCQEDGICIPNF 1247
Query: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
W CDG DC+ SDE + V C PS F C D+ CI +AW+CD DNDC D SDE++
Sbjct: 1248 WECDGHPDCLYGSDEHNA-CVPKTC-PSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKD 1304
Query: 1140 CESLACRPPSHP--CANNTSVCLPPDKLCDGNDDCGDGSDEGELCD--QCSLNNGGCSHN 1195
C + R PS C + ++C+ +CDG DC +G+DE LC+ CS NGGC+H
Sbjct: 1305 CPTQPFRCPSWQWQCLGH-NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHE 1363
Query: 1196 CSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLE 1255
C P G C CPLG L D+ TC+ C CSQ C + S +CSC G++LE
Sbjct: 1364 CVQEPF-GAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLE 1422
Query: 1256 PDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSV--LVPGLRNTIALDFHLSQSALYW 1313
DG +C+ ++ +++++I + +++ LV +A+DF ++W
Sbjct: 1423 SDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFW 1482
Query: 1314 TDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKL 1373
+D + K + NG T VV + E +A+DW+ N+YW + L+ IEV+K+
Sbjct: 1483 SDATQGKTWSA--FQNG--TDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKI 1538
Query: 1374 DGTLRTTLLAGDIEHPRAIALDPR--DGILFWTDWDASLPRIEAASMSGAGRRTVHRETG 1431
DG+ RT L++ ++ +PR +ALDPR + +LFW+DW PRIE ASM G+ R + ++
Sbjct: 1539 DGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH-PRIERASMDGSMRTVIVQDKI 1597
Query: 1432 SGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEV 1491
WP GLT+DY + + ++D+ D + Y+G +V+ + HP+A+TL+ V
Sbjct: 1598 F--WPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSV 1655
Query: 1492 YWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSH 1551
YWTD T + +ANKW G N +VV P + HPS+QP + NPC + CSH
Sbjct: 1656 YWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSH 1711
Query: 1552 LCLINYN--RTVSCACPHLMKLHKDNTTCY-EFKKFLLYARQMEIRGVDLDAPYYNYIIS 1608
LCL++ SC CP L D C + + FL+ RQ I G+ L+ +
Sbjct: 1712 LCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAM 1771
Query: 1609 FTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPN-AHGLAVDW 1667
+ I N +++D EQ +YW + I R +GT S + + LA+DW
Sbjct: 1772 VPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNLALDW 1830
Query: 1668 VSRNLFWTSYDTNKKQINVARLDGSFKNAVVQ------GLEQPHGLVVHPLRGKLYWTDG 1721
+SRNL+ T+ T ++ D ++ ++ G+ P G+ V P RGKLYW+D
Sbjct: 1831 ISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQ 1890
Query: 1722 DN-------ISMANMDGSNRTLLFSGQKGPVG-LAIDFPESKLYWISSGNHTINRCNLDG 1773
I+ ANMDG++ LF+G + + +D E KLYW +G I R N+DG
Sbjct: 1891 GTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDG 1950
Query: 1774 SGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHM 1833
+ ++ QL +A+ L++ D+ E + KA G+ +VLR++ + +
Sbjct: 1951 TDRMILV---HQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGL 2007
Query: 1834 KVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFL 1893
+VY + +N CS N C Q+CLP SC C G+ L ++C SF+
Sbjct: 2008 QVYHRRNAAE--SSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFI 2065
Query: 1894 LYSVHEGIRGIPLDPNDKSDALVPVSGTSL-AVGIDFHAENDTIYWVDMGLSTIS----- 1947
+ S+ IRG L+ +D S+ +VPV+G A+ +D + IYW D S S
Sbjct: 2066 VVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIR 2125
Query: 1948 RAKRDQTWREDVVTNGIGR--VEGIAVDWIAGNIYWTDQGFD--VIEVARLNGSFRYVVI 2003
R K D + ++VT+GIG V GIAVDW+AGN+Y+T+ +IEV R+N ++R V++
Sbjct: 2126 RIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLL 2185
Query: 2004 SQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQD 2063
+D PR I V P+ YLFW ++GQ P+IERS LD T R VLV+ I P G++VD D
Sbjct: 2186 KVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSD 2245
Query: 2064 GKLYWCDARTDKIERIDLETGENREVV-LSSNNMDMFSVSVFEDFIYWSDRTHANGSIKR 2122
G +YW D D I RI + GEN EV+ S + ++VFE+ I W DR
Sbjct: 2246 GYVYWVDDSLDIIARIRIN-GENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQAS 2304
Query: 2123 GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQK------GTNVCAVANGGCQQLCL-YRGR 2175
+N +R I L+D+ +F++ Q N C NGGC LC G
Sbjct: 2305 KEPENTEPPTVIRDNIN-WLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGL 2363
Query: 2176 GQRACACAHGMLAEDGASCR-EYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMK 2234
C CA G L DG +C +L+++ L+S+HL E + PF+ +
Sbjct: 2364 HTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHS----PPFQTINVER 2419
Query: 2235 NVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN----DDGSRRITIVEN-VGSVEGLA 2289
V++L +D +RI+F+ + QI+ G T++ + +G+ +G+A
Sbjct: 2420 TVMSLDYD-------SVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIA 2472
Query: 2290 YHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWT 2349
+ +Y++ Y I D + TVI PRA VLD CQ ++W
Sbjct: 2473 FDWITRRIYYSDYLNQMINSMAEDGSN------RTVIARV--PKPRAIVLDPCQGYLYWA 2524
Query: 2350 NWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGS 2409
+W + H I RA L G + ++ + P+GL +D+ + LY+ DA+L +IER G
Sbjct: 2525 DW-DTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGV 2583
Query: 2410 HRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGI-I 2468
R VI+ + VH FGL +YG++I+WTD + + RANK+ GS + ++ QP GI
Sbjct: 2584 DREVIVNAA-VHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINT 2642
Query: 2469 AVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC--RGGRILQDDLT-CRAVNSSCR 2525
V N C +PC NGGC +C G C C G L ++ C N
Sbjct: 2643 VVKNQKQQCN-NPCEQFNGGCSHICAPGPNG-AECQCPHEGNWYLANNRKHCIVDNGERC 2700
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
F C+NG CI+ CD C D SDE S C C T C+NGRCV C
Sbjct: 2701 GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
Query: 2586 NGADDCGDGSDEIPCNKTACGVG-EFRCRDGTCIGNSSRCNQFVDCED--ASDEMNCSAT 2642
+ +DCGDGSDE C C EF C + CI CN +C D SDE NC
Sbjct: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR 2820
Query: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFA 2702
C S + C +++C ++CDG NDCGD SDE C + F
Sbjct: 2821 TCQSGYT---------KCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHT-CSSSEFQ 2870
Query: 2703 CPSGRCIPMSWTCDKEDDCEHGEDET----HCNKFCSEAQFECQNHRCISKQWLCDGSDD 2758
C SGRCIP W CD+E DC DE H + C +F+C RCI +W+CDG +D
Sbjct: 2871 CASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDND 2930
Query: 2759 CGDGSDEAAH--CEGKTCGPSSFSC----PGTHVCVPERWLCDGDKDCADGADESIAAGC 2812
CGD SDE C+ + C S F C P C+P+ W+CDGD DC DG DE+ C
Sbjct: 2931 CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN--QNC 2988
Query: 2813 LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLS 2872
TC + EF C CIPK F CD DC D SDE C Y TC ++F C NGRC+S
Sbjct: 2989 T-RRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERG-CLYQTCQQNQFTCQNGRCIS 3046
Query: 2873 SRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGD 2932
+ + CD +NDC D SDE C + E C +F C +GRC+ LCN DDC D
Sbjct: 3047 -KTFVCDEDNDCGDGSDELMHL--CHTPEPTC-PPHEFKCDNGRCIEMMKLCNHLDDCLD 3102
Query: 2933 SSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTT-FP 2991
+SDE+GC INEC +SGC +C D F C CRPG++L D RTC D+DEC+ F
Sbjct: 3103 NSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFV 3162
Query: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051
CSQ+C N GSY C C GY R D +C+ ++ EP+LIF+NRYYLR L +DG Y+L
Sbjct: 3163 CSQKCENVIGSYICKCAPGYL-REPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSL 3221
Query: 3052 LKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3111
+ +GL+N VALDFD E+ +YW D TQ +I RM LN +N + + L + LAVDW
Sbjct: 3222 ILEGLDNVVALDFDRVEKRLYWID--TQRQVIERMFLNKTNKETIINHRLPAAESLAVDW 3279
Query: 3112 VGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLR--------EPRALVVDVQNGYLYWTD 3163
V LYW D D + VS LNG +R +L + PR L + Q GYLYW D
Sbjct: 3280 VSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWAD 3339
Query: 3164 WGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNR 3223
WG + IGR+GMDG+++SVI+ TK+ WPNG+T+DY + +YWADA YIE++ L+G +R
Sbjct: 3340 WGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Query: 3224 HVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHA 3283
H V +PH FA+T+FED +YWTDW T+++ + +K G+N+ L++T HRP D+HV+H
Sbjct: 3400 HTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP 3459
Query: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPGG-GHKCACPTNF-YLGSDGRT-CVSNCTASQFV 3340
RQP V N PC NNGGCS+LCL+ PGG G C CP +F L G T C+ C+++QF+
Sbjct: 3460 YRQPIVSN-PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFL 3518
Query: 3341 C-KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDC 3399
C N+KCIP WWKCD + DC D SDE CP+ CR GQFQCS G CT+P +C+ +C
Sbjct: 3519 CANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNC 3578
Query: 3400 QDNSDEAN--CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDG--EDERDCPEVTCAP 3455
D SDE C+ H C ++++C N RCIP ++C+ ++C D ED C TC P
Sbjct: 3579 PDGSDEDRLLCENHHCDSNEWQCAN-KRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRP 3637
Query: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEP----ANCTQMTCGVDEFRCKDSGRCIPAR 3511
QF+C+ RCIP+ W CD DNDC D SDEP + + EF CK + RCIP
Sbjct: 3638 GQFRCA-NGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKW 3696
Query: 3512 WKCDGEDDCGDGSDEPKEECDERTCEPY-QFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
C+G DDC D SDE + C+ERTC P FRCKN+ C+P RWQCD NDCGDNSDEE+C
Sbjct: 3697 AVCNGVDDCRDNSDE--QGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Query: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPR-CDMDQFQCKSGHCIPLR 3629
PR C+ESEF C N +CI RW CD +DC D SDE+DC R C + FQC SGHC+
Sbjct: 3755 APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSE 3814
Query: 3630 WRCDADADCMDGSDEEACGTGV---RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN 3686
+CD ADC+D SDE C T C F+C N +C P WKCDG+DDCGD SDE
Sbjct: 3815 LKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
Query: 3687 PEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTD--EEDCEPPTAHTTHCKDK 3744
C C FRC N+R C++ C+G D+CGDGTD EE C PT +
Sbjct: 3875 LHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPC---TE 3930
Query: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKA 3804
E+ C N C+ C+ DDCGD SDE C+ K +CA N IC E C + +
Sbjct: 3931 YEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN-KGKERTCAEN--IC--EQNCTQLNEG 3985
Query: 3805 AY-CACRSGFHT-VPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFM----KTHN 3858
+ C+C +GF T V + C DINEC +FGTC Q C NTKG + C CA F +
Sbjct: 3986 GFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGK 4045
Query: 3859 TCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWT 3917
C AEGS +L + D+ IR S Y Q + ++V D + VY+T
Sbjct: 4046 RCAAEGSS-PLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYT 4104
Query: 3918 NWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDS 3977
G+ + ++ A P + + L + + P GIA+DWV ++YW+D
Sbjct: 4105 VRGEGS-RFGAIKRAYIPNFESGRNNLVQE--VDLKLKYVMQPDGIAVDWVGRHIYWSDV 4161
Query: 3978 GRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRE 4037
IEVA++ G RK LIS +D+P AI V+P G M+W+DWG PKIE+A M+G R
Sbjct: 4162 KNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRN 4221
Query: 4038 TLVQDNIQWPTGLAVDY-HNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSID 4096
LV +++ WPTGL++DY +N+R+YW+D K VI +I+ +GTD V A + +P+S+D
Sbjct: 4222 ILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIA---KEAMNPYSLD 4278
Query: 4097 VFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK-QPEVTNPCDRKK 4155
+FED +Y ++ V+K +KFG + V ++HQ + V N C ++
Sbjct: 4279 IFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLC-KQI 4337
Query: 4156 CEWLCLLSPSGPVCTCPNGKRLDNGT------CVPVPSPTPPPDAPRPGTCNLQCFNGGS 4209
C LCLL P G C CP G G+ + +P PPP +C +GG+
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP---------CRCMHGGN 4388
Query: 4210 CFLNARRQPKCRCQPRYTGDKCEL 4233
C+ + PKC+C YTG CE+
Sbjct: 4389 CYFDETDLPKCKCPSGYTGKYCEM 4412
Score = 693 bits (1789), Expect = 0.0
Identities = 472/1473 (32%), Positives = 666/1473 (45%), Gaps = 198/1473 (13%)
Query: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051
CS C G + C + D +C T E FLIFA LR L+LD N++
Sbjct: 2353 CSHLCFALPGLHTPKCDCAFGTLQSDGKNCAIST--ENFLIFALSNSLRSLHLDPENHSP 2410
Query: 3052 LKQGLN---NAVALDFDYREQMIYWTDVTTQG-SMIRRMHLN-GSNVQVLHRTGLSNPDG 3106
Q +N ++LD+D IY+T G I L+ G + + +G+ DG
Sbjct: 2411 PFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADG 2470
Query: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
+A DW+ +Y+ D I +G+ RTV+ + +PRA+V+D GYLYW DW
Sbjct: 2471 IAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWADWDT 2528
Query: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226
H+ I R + G+ R IV++ + P+GLTLDY + +YW DA IE ++L G +R V+
Sbjct: 2529 HAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVI 2588
Query: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTL-HRPMDLHVFHALR 3285
++ + H F LTL+ Y+YWTD T+ I RA+K G+ + + + L +P ++
Sbjct: 2589 VNAAV-HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTV-VKN 2646
Query: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPT--NFYLGSDGRTCVSNCTASQFVCKN 3343
Q N+PC+ NGGCS++C P G +C CP N+YL ++ + C+
Sbjct: 2647 QKQQCNNPCEQFNGGCSHICAPGPNGA-ECQCPHEGNWYLANNRKHCI------------ 2693
Query: 3344 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNS 3403
D + CG S F CS G C + + CD DNDC D S
Sbjct: 2694 ---------VDNGERCGASS---------------FTCSNGRCISEEWKCDNDNDCGDGS 2729
Query: 3404 DEAN--CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTC-APNQFQC 3460
DE C +H C P+ F C N RC+ +RC+ ++CGDG DE C C A +F C
Sbjct: 2730 DEMESVCALHTCSPTAFTCAN-GRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC 2788
Query: 3461 SITKRCIPRVWVCDRDNDCVDGS-DEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDD 3519
+ +RCIPR ++C+ ++C D + + NC TC +C +S CIP + CDG++D
Sbjct: 2789 N-NRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDND 2847
Query: 3520 CGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEE-SC--TPRPCS 3576
CGD SDE C TC +F+C + RC+P W CD + DC D SDE SC + R C
Sbjct: 2848 CGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCL 2907
Query: 3577 ESEFSCANGRCIAGRWKCDGDHDCADGSDEK---DC-TPRCDMDQFQCKSGH-----CIP 3627
EF C GRCI W CDGD+DC D SDE C C +F C + CIP
Sbjct: 2908 ADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIP 2967
Query: 3628 LRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP 3687
W CD D DC DG DE T RTC +EF C LC P ++CD +DCGD SDE
Sbjct: 2968 QSWVCDGDVDCTDGYDENQNCTR-RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERG 3026
Query: 3688 EECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKK-- 3745
C C N+ F C+N R C+ CD ++CGDG+DE H H +
Sbjct: 3027 --CLYQTCQQNQ-FTCQNGR-CISKTFVCDEDNDCGDGSDE------LMHLCHTPEPTCP 3076
Query: 3746 --EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEK 3803
EF C N RC+ CN DDC D SDE+ C I+ + SI G + C T
Sbjct: 3077 PHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINE-----CHDPSISGCDHNCTDTLT 3131
Query: 3804 AAYCACRSGFHTVPGQPGCQDINECLRFG-TCSQLCNNTKGGHLCSCARNFMKTHN--TC 3860
+ YC+CR G+ + + C DI+EC CSQ C N G ++C CA +++ + TC
Sbjct: 3132 SFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTC 3191
Query: 3861 KAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNW 3919
+ + L ++ +R+L G+ +S + + A+D R+YW +
Sbjct: 3192 RQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDN-----VVALDFDRVEKRLYWIDT 3246
Query: 3920 HTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGR 3979
I L T N HR L +A+DWV+ +YW D+
Sbjct: 3247 QRQVIERMFLNKTNKETIIN-HR--------------LPAAESLAVDWVSRKLYWLDARL 3291
Query: 3980 DVIEVAQMKGENRKTLISGMID--------EPHAIVVDPLRGTMYWSDWGNHPKIETAAM 4031
D + V+ + G +R+ L +D P + + P G +YW+DWG+ I M
Sbjct: 3292 DGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGM 3351
Query: 4032 DGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSH 4091
DGT + ++ ++WP G+ +DY N+ LYWADA L I L G D L H
Sbjct: 3352 DGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDG--ALPH 3409
Query: 4092 PFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC 4151
PF+I +FED IY + V K +K+ S L D+ +YH ++QP V+NPC
Sbjct: 3410 PFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPC 3469
Query: 4152 DRKK--CEWLCLLSPSGP--VCTCPNGKR---LDNGT-CVPVPSPTPPPDAPRPGTCNLQ 4203
C LCL+ P G C CP+ R L T C+P+ S T
Sbjct: 3470 GTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSST-----------QFL 3518
Query: 4204 CFNGGSCFLNARRQP---KCRCQPRYTGDKCELDQCWEH-CRNG------GTCAASPSGM 4253
C N C P KC Q + EL C + CR G G C SP +
Sbjct: 3519 CANNEKCI------PIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCT-SPQTL 3571
Query: 4254 PTCR--CPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGY 4311
CP G + N C N+ RC+P S
Sbjct: 3572 CNAHQNCPDGSDEDRLL--------CENHHCDSNEWQCANKRCIPE-----------SWQ 3612
Query: 4312 CENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCTD 4367
C+ F C+ +D + S C C RC G C+ DV +C D
Sbjct: 3613 CDTFNDCEDNSDE----------DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGD 3662
Query: 4368 GRVAP--SCLTCVGHCSN--GGSCTMNSKMMPE 4396
P C++ C N SC N + +P+
Sbjct: 3663 HSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPK 3695
Score = 638 bits (1645), Expect = 0.0
Identities = 372/1068 (34%), Positives = 537/1068 (50%), Gaps = 88/1068 (8%)
Query: 840 VTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDR 899
V CLA S +C F C + CI W+CDG DC D++DE C TC
Sbjct: 17 VACLAPAS---GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGY 71
Query: 900 FKCENN-RCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLD 958
FKC++ +CIPN W+CD D DC + DE CS TC +Q +C++G+CIP + CD
Sbjct: 72 FKCQSEGQCIPNSWVCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCIPSEYRCDHV 130
Query: 959 DDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSST 1018
DC D +DE+ C YPTC Q TC+NG C N + +CD DC D+SDE C+ C
Sbjct: 131 RDCPDGADEN-DCQYPTC---EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHN 186
Query: 1019 QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPL 1078
+F C +G CIP + CD DNDC D SDE N C +F C G CI
Sbjct: 187 EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT--------CGGYQFTCP-SGRCIYQ 237
Query: 1079 RWRCDGDTDCMDSSDEKSCEG---VTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNS 1135
W CDG+ DC D+ DE CE H C P ++ C +S RCIS VCDG DC
Sbjct: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPR-EWSCPESGRCISIYKVCDGILDCPGRE 296
Query: 1136 DEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHN 1195
DE NNTS G+ C + C +
Sbjct: 297 DE----------------NNTST--------------------GKYCSMTLCSALNCQYQ 320
Query: 1196 CSVAPGEGIVCSCPLGMELG-PDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVL 1254
C P G C CP G + D+ TC C C QKC+ C C EG++L
Sbjct: 321 CHETPYGG-ACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYIL 379
Query: 1255 EPDGESCRSLDPF-KPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD--FHLSQSAL 1311
E G+ C++ D F + IIFSN ++ D+H + +LV +A+ FH +
Sbjct: 380 E-RGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRV 438
Query: 1312 YWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVA 1371
+WTD V++K++ + NG + + V+ + TPE LAVDW+ IY VE+ +++I++
Sbjct: 439 FWTDTVQNKVFSVDI--NG--LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMV 494
Query: 1372 KLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWD--ASLPRIEAASMSGAGRRTVHRE 1429
LDG+ R TL+ ++ HPR IA+DP G LF++DW+ + P++E A M G+ R+ + +
Sbjct: 495 NLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKT 554
Query: 1430 TGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGG 1489
GWP G+T+D + KR+ W+D+R D I + YDG V+ G + HPF V+L+ G
Sbjct: 555 --KLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEG 612
Query: 1490 EVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPC 1549
+V++TDW + KANK+T N V + + +P+ + VYH RQP A NPC+ N G C
Sbjct: 613 QVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN--NGGC 670
Query: 1550 SHLCLINYNRT-----VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604
+C++++ C C +L D C + FL+++ Q+ IRG+
Sbjct: 671 EQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQE 730
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
++ + +D+DA++ +++SD+ I + I+GTG E + + + N LA
Sbjct: 731 DVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLA 790
Query: 1665 VDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTD---G 1721
DW+S+NL+WT D++ K I+V RL + VVQ L P +VVHP G L++TD
Sbjct: 791 FDWISKNLYWT--DSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRP 848
Query: 1722 DNISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVID 1780
I A DGS+ + + G P GLAID+ S+LYW+ + I DG +
Sbjct: 849 AKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLG 908
Query: 1781 AMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESI 1840
+ Q+ LAI G+ L++ D + KADG V+R+ ++H+K YD +I
Sbjct: 909 HI-EQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNI 967
Query: 1841 QLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEG 1888
Q N + NGDCS C P R C C G L S CEG
Sbjct: 968 QTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEG 1015
Score = 428 bits (1100), Expect = e-119
Identities = 261/755 (34%), Positives = 369/755 (48%), Gaps = 91/755 (12%)
Query: 2599 PCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC-SSYFRLGVKGVLF 2657
P + C FRC G CI RC+ DC D +DE+ C+ C YF+
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFK-------- 73
Query: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDER-DCPGVKRPRCPLNYFACPSGRCIPMSWTCD 2716
C+ C SWVCD DC D SDER DC + C + C +G+CIP + CD
Sbjct: 74 --CQSEGQCIPNSWVCDQDQDCDDGSDERQDC---SQSTCSSHQITCSNGQCIPSEYRCD 128
Query: 2717 KEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGP 2776
DC G DE C ++ + Q C N C + CD DC D SDE +C + C
Sbjct: 129 HVRDCPDGADENDC-QYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDE-INCT-EICLH 185
Query: 2777 SSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFV 2836
+ FSC G C+P ++CD D DC DG+DE C Y TC +F C + +CI +++V
Sbjct: 186 NEFSC-GNGECIPRAYVCDHDNDCQDGSDEH---ACNY-PTCGGYQFTCPSGRCIYQNWV 240
Query: 2837 CDHDRDCADGSD----ESPECEYPTCGPSEFRC-ANGRCLSSRQWECDGENDCHDQSDEA 2891
CD + DC D D ES + C P E+ C +GRC+S + CDG DC + DE
Sbjct: 241 CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYK-VCDGILDCPGREDEN 299
Query: 2892 PKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSG 2951
N S+ CS C A
Sbjct: 300 -------------NTSTGKYCSMTLCSA------------------------------LN 316
Query: 2952 CSQDCEDLKIGFKCRCRPGFRLK-DDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEG 3010
C C + G C C PG+ + +D RTC + D+C C Q+C + G + C C EG
Sbjct: 317 CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEG 376
Query: 3011 YAPRGGDPHSCKAVTD-EEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALD--FDYR 3067
Y G CKA E +IF+N L ++ G ++ +L + N VA+ F Y
Sbjct: 377 YILERG--QYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYH 434
Query: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127
Q ++WTD T + + + +NG N+Q + + P+ LAVDWV +Y + + I+
Sbjct: 435 LQRVFWTD--TVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRID 492
Query: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS---LIGRIGMDGSSRSVIV 3184
+ L+G+YR L++ L PR + VD GYL+++DW S + R MDGS+R +V
Sbjct: 493 MVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLV 552
Query: 3185 DTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVL--SQDIPHIFALTLFED 3242
TK+ WP G+TLD +++R+YW D+R DYIE + DG R V+ IPH F ++LFE
Sbjct: 553 KTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEG 612
Query: 3243 YVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCS 3302
V++TDW ++ +A+K T TN + RP + V+H+LRQP N PCK NNGGC
Sbjct: 613 QVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATN-PCKDNNGGCE 671
Query: 3303 NLCLLS-----PGGGHKCACPTNFYLGSDGRTCVS 3332
+C+LS G G +C C F L +D R C++
Sbjct: 672 QVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIA 706
Score = 369 bits (948), Expect = e-101
Identities = 269/879 (30%), Positives = 412/879 (46%), Gaps = 93/879 (10%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDE----APEICPQS------------ 67
P C +F C++ CI W CDG DC GSDE P+ CP S
Sbjct: 1227 PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHR 1286
Query: 68 ---------------------KAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGP 106
+ RC + CLG +CV +S +C+G+ DC +G+DE P
Sbjct: 1287 AWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESP 1346
Query: 107 HCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTN 166
C + GC H CV G C C F L D KTC+D DEC + G+CSQ C N
Sbjct: 1347 LCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYN 1406
Query: 167 TDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTI--TP 224
GSF C C GY+L+ D R+CK +LL+A+ I+A ++ +QV I
Sbjct: 1407 MRGSFRCSCDTGYMLESDGRTCKV---TASESLLLLVASQNKIIADSVT-SQVHNIYSLV 1462
Query: 225 TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQ 284
+ A+DF + + W A Q + A G + + S+ E
Sbjct: 1463 ENGSYIVAVDFDSISGRIFW----SDATQGKTWSAFQNG-----TDRRVVFDSSIILTET 1513
Query: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGK--VFFTDY 342
+AIDW+ N Y+ D + I V +G L+ L NP+G+ALDP M + +F++D+
Sbjct: 1514 IAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDW 1573
Query: 343 GQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG-KGR 401
G P++ER MDG RT +V KI +P G+T+D +RL+Y+ D+YLDY++ DY G R
Sbjct: 1574 GHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRR 1633
Query: 402 QTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-RVDKGG 460
Q I ++I H Y LT+FE+ +Y T D A + V+R N+++ VV +
Sbjct: 1634 QVIASDLIIRHPYALTLFEDSVYWT--DRATRR----VMRANKWHGGNQSVVMYNIQWPL 1687
Query: 461 ALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLAN-SHKARTCRCRSGFSLGSDGKSC 519
+ H +QP + C + CS +CLL++ +C C SG+SL D +C
Sbjct: 1688 GIVAVHPSKQPN-SVNPCAFSR------CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC 1740
Query: 520 KKPEHELFLVYGKGRPGIIRGMDMGAKV-PDEHMIPIENLMNPRALDFHAETGFIYFADT 578
+ + + R II G+ + +V ++ M+PI + N ++F +IY+ +
Sbjct: 1741 LRDDQPFLITV---RQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVEN 1797
Query: 579 TSYLIGRQKIDGTERETILKDGIHNVE-GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQ 637
I R K DGT R + +A+DW+ NLY T+ ++I V L +
Sbjct: 1798 PGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNP-RTQSIEVLTLHGDIR 1855
Query: 638 TRKTLIEGKMT-----HPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDG-SHRDI 691
RKTLI T P I VDP G +YW+D D ++ A MDG S + +
Sbjct: 1856 YRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTD--SGVPAKIASANMDGTSVKTL 1913
Query: 692 FVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHH 751
F + L ++LDI +LYW IE ++GTDR I+ +L+H +G+ H
Sbjct: 1914 FTGNLEHL--ECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH--QLSHPWGIAVH 1969
Query: 752 GNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNN 811
++L++T+ + + R+++ G +LR P + +++Y + +N C N
Sbjct: 1970 DSFLYYTDEQYEVIERVDKATGA---NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNM 2026
Query: 812 GGCSSLCLATPGSR-QCACAEDQVLDADGVTCLANPSYV 849
C +CL PG CACA L+ D +C S++
Sbjct: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFI 2065
Score = 246 bits (628), Expect = 4e-64
Identities = 139/373 (37%), Positives = 180/373 (48%), Gaps = 46/373 (12%)
Query: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWV 3472
C + F+C + CIP +RC+G +C D DE C VTC F+C +CIP WV
Sbjct: 28 CDSAHFRC-GSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
Query: 3473 CDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECD 3532
CD+D DC DGSDE +C+Q TC + C +G+CIP+ ++CD DC DG+DE +C
Sbjct: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITC-SNGQCIPSEYRCDHVRDCPDGADE--NDCQ 143
Query: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
TCE Q C N C +CD+ DC D+SDE +CT C +EFSC NG CI +
Sbjct: 144 YPTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-EICLHNEFSCGNGECIPRAY 200
Query: 3593 KCDGDHDCADGSDEKDCT-PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTG- 3650
CD D+DC DGSDE C P C QF C SG CI W CD + DC D DE+ C +G
Sbjct: 201 VCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
Query: 3651 --VRTCPLDEFQC-NNTLCKPLAWKCDGEDDCGDNSDENPEECARF-------------- 3693
V C E+ C + C + CDG DC DEN ++
Sbjct: 261 HDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQ 320
Query: 3694 ----------VCPPNRPFRCKNDRVCLWIGRQCDGTDNCGD-GTDEEDCEP-PTAHTTHC 3741
CPP + R C+ D+C G ++ CE P H HC
Sbjct: 321 CHETPYGGACFCPPGYIINHNDSRTCVEF-------DDCQIWGICDQKCESRPGRHLCHC 373
Query: 3742 KDKKEFLCRNQRC 3754
++ L R Q C
Sbjct: 374 -EEGYILERGQYC 385
Score = 194 bits (494), Expect = 1e-48
Identities = 115/339 (33%), Positives = 157/339 (46%), Gaps = 40/339 (11%)
Query: 2530 FECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC-SNGRCVSNMLWCNGA 2588
F C +G CI CDG C D +DE C C++ + +C S G+C+ N C+
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADE--IGCAVVTCQQGYFKCQSEGQCIPNSWVCDQD 90
Query: 2589 DDCGDGSDE-IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSY 2647
DC DGSDE C+++ C + C +G CI + RC+ DC D +DE +C C
Sbjct: 91 QDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQL 150
Query: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR 2707
C+ CY S CD DC D SDE +C + C N F+C +G
Sbjct: 151 -----------TCD-NGACYNTSQKCDWKVDCRDSSDEINCTEI----CLHNEFSCGNGE 194
Query: 2708 CIPMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2766
CIP ++ CD ++DC+ G DE CN C QF C + RCI + W+CDG DDC D DE
Sbjct: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDED 254
Query: 2767 AHCEG-----KTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDR 2821
CE C P +SCP + C+ +CDG DC DE+ + Y S
Sbjct: 255 G-CESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
Query: 2822 EFMCQNRQC----------IPKHFVCDHD--RDCADGSD 2848
CQ QC P ++ +H+ R C + D
Sbjct: 314 ALNCQ-YQCHETPYGGACFCPPGYIINHNDSRTCVEFDD 351
Score = 185 bits (469), Expect = 1e-45
Identities = 105/260 (40%), Positives = 131/260 (50%), Gaps = 13/260 (5%)
Query: 3331 VSNCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNP 3389
V C F C+++ +CIP W CD + DC D SDE DC + C Q CS G C
Sbjct: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPS 123
Query: 3390 AFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCP 3449
+ CD DC D +DE +C C Q C N C +C+ + +C D DE +C
Sbjct: 124 EYRCDHVRDCPDGADENDCQYPTC--EQLTCDN-GACYNTSQKCDWKVDCRDSSDEINCT 180
Query: 3450 EVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIP 3509
E+ C N+F C CIPR +VCD DNDC DGSDE A C TCG +F C SGRCI
Sbjct: 181 EI-CLHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHA-CNYPTCGGYQFTC-PSGRCIY 236
Query: 3510 ARWKCDGEDDCGDGSDEPKEEC---DERTCEPYQFRC-KNNRCVPGRWQCDYDNDCGDNS 3565
W CDGEDDC D DE E D C P ++ C ++ RC+ CD DC
Sbjct: 237 QNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE 296
Query: 3566 DE-ESCTPRPCSESEFSCAN 3584
DE + T + CS + S N
Sbjct: 297 DENNTSTGKYCSMTLCSALN 316
Score = 171 bits (434), Expect = 1e-41
Identities = 121/388 (31%), Positives = 158/388 (40%), Gaps = 72/388 (18%)
Query: 801 QVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFA 860
Q G KC+ + G C + C D+ D TC ++ QC P E+
Sbjct: 68 QQGYFKCQ-SEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEY- 125
Query: 861 CANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDC 920
+CD DC D +DE C TC ++ C+N C CD DC
Sbjct: 126 -----------RCDHVRDCPDGADEND--CQYPTC--EQLTCDNGACYNTSQKCDWKVDC 170
Query: 921 GNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLT 980
+S DE N T C N+FSC +G CIP ++ CD D+DC D SDE A C YPTC
Sbjct: 171 RDSSDEINCT---EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA-CNYPTCGGY- 225
Query: 981 QFTCNNGRCININWRCDNDNDCGDNSDEAGCS------HSCSSTQFKC-NSGRCIPEHWT 1033
QFTC +GRCI NW CD ++DC DN DE GC H CS ++ C SGRCI +
Sbjct: 226 QFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKV 285
Query: 1034 CDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSD 1093
CDG DC DE + + + ++QC
Sbjct: 286 CDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQC------------------------ 321
Query: 1094 EKSCEGVTHVCDPSVKFGCKDSARCIS----KAW-VCDGDNDCEDNSDEENCESLACRPP 1148
++ G C P DS C+ + W +CD + CES RP
Sbjct: 322 HETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICD-----------QKCES---RPG 367
Query: 1149 SHPCANNTSVCLPPDKLCDGNDDCGDGS 1176
H C L + C ND G+ S
Sbjct: 368 RHLCHCEEGYILERGQYCKANDSFGEAS 395
Score = 169 bits (427), Expect = 8e-41
Identities = 99/270 (36%), Positives = 130/270 (48%), Gaps = 28/270 (10%)
Query: 2513 DDLTCRAVNSSCRAQDEFEC-ANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFR 2571
D++ C V +C+ Q F+C + G+CI S CD C D SDE+ C+ C
Sbjct: 58 DEIGCAVV--TCQ-QGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQSTCSSHQI 113
Query: 2572 QCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCE 2631
CSNG+C+ + C+ DC DG+DE C C + C +G C S +C+ VDC
Sbjct: 114 TCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCR 171
Query: 2632 DASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGV 2691
D+SDE+NC+ + F G C ++VCD NDC D SDE C
Sbjct: 172 DSSDEINCTEICLHNEFSCG-----------NGECIPRAYVCDHDNDCQDGSDEHAC--- 217
Query: 2692 KRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNK------FCSEAQFEC-QNH 2744
P C F CPSGRCI +W CD EDDC+ DE C CS ++ C ++
Sbjct: 218 NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESG 277
Query: 2745 RCISKQWLCDGSDDCGDGSDEAAHCEGKTC 2774
RCIS +CDG DC DE GK C
Sbjct: 278 RCISIYKVCDGILDCPGREDENNTSTGKYC 307
Score = 104 bits (259), Expect = 2e-21
Identities = 61/180 (33%), Positives = 84/180 (46%), Gaps = 21/180 (11%)
Query: 3297 NNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTE 3356
+NG C N KC + SD C C ++F C N +CIP + CD +
Sbjct: 153 DNGACYNT-------SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHD 205
Query: 3357 DDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC-----DIH 3411
+DC D SDE C C QF C +G C ++CDG++DC+DN DE C D+H
Sbjct: 206 NDCQDGSDEHA-CNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVH 264
Query: 3412 VCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERD------CPEVTCAP--NQFQCSIT 3463
C P ++ C + RCI C+G +C EDE + C C+ Q+QC T
Sbjct: 265 KCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHET 324
Score = 93.6 bits (231), Expect = 4e-18
Identities = 64/213 (30%), Positives = 94/213 (44%), Gaps = 28/213 (13%)
Query: 3654 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIG 3713
C F+C + C P W+CDG DC D++DE CA C F+C+++ C+
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIG--CAVVTCQQGY-FKCQSEGQCIPNS 84
Query: 3714 RQCDGTDNCGDGTDE-EDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
CD +C DG+DE +DC T + + C N +C+ S RC+ DC DG+D
Sbjct: 85 WVCDQDQDCDDGSDERQDCSQSTCSS------HQITCSNGQCIPSEYRCDHVRDCPDGAD 138
Query: 3773 EEDCSID--PKLT----SCATNASIC---------GDEARCVRTEKAAYCACRSGFHTVP 3817
E DC +LT +C + C DE C +C +G +P
Sbjct: 139 ENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNG-ECIP 197
Query: 3818 GQPGCQDINECLRFGTCSQLCN-NTKGGHLCSC 3849
C N+C + G+ CN T GG+ +C
Sbjct: 198 RAYVCDHDNDC-QDGSDEHACNYPTCGGYQFTC 229
Score = 78.6 bits (192), Expect = 1e-13
Identities = 46/109 (42%), Positives = 57/109 (52%), Gaps = 10/109 (9%)
Query: 23 APKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQP-NEHNCLG 81
A +TC P QF C + CI + W+CD + DC D SDE E C S A C E +C
Sbjct: 3631 ASRTCRPGQFRCANG-RCIPQAWKCDVDNDCGDHSDEPIEEC-MSSAHLCDNFTEFSCKT 3688
Query: 82 TELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLG---CQ-HHCVP 126
C+P +CNGV DC D SDE C E C +G C+ HHC+P
Sbjct: 3689 NYRCIPKWAVCNGVDDCRDNSDE-QGCEE--RTCHPVGDFRCKNHHCIP 3734
Score = 73.2 bits (178), Expect = 6e-12
Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 26/139 (18%)
Query: 22 DAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLG 81
++ +TC P QF C + CI + CDG++DC DGSDE + C ++ C
Sbjct: 1144 NSTETCQPSQFNCPNH-RCIDLSFVCDGDKDCVDGSDEVGCVL------NCTASQFKCAS 1196
Query: 82 TELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQL 141
+ C+ ++ C+GV DC D SDE GC PT C+ + FQ
Sbjct: 1197 GDKCIGVTNRCDGVFDCSDNSDEA-------------GC-----PTRPPGMCH-SDEFQC 1237
Query: 142 QADGKTCKDFDECSVYGTC 160
Q DG +F EC + C
Sbjct: 1238 QEDGICIPNFWECDGHPDC 1256
Score = 72.8 bits (177), Expect = 7e-12
Identities = 54/170 (31%), Positives = 77/170 (45%), Gaps = 39/170 (22%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
TC F C+ + CI W CD ++DC DGSDE + C QS C ++ C + C
Sbjct: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD-CSQS---TCSSHQITCSNGQ-C 120
Query: 86 VPMSRLCNGVQDCMDGSDEG----PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQL 141
+P C+ V+DC DG+DE P C +L T D CY S
Sbjct: 121 IPSEYRCDHVRDCPDGADENDCQYPTCEQL---------------TCDNGACYNTSQ--- 162
Query: 142 QADGKT-CKD-FDECSVYGTCSQLCTNTDGSFICG---CV-EGYLLQPDN 185
+ D K C+D DE + C+++C + + F CG C+ Y+ DN
Sbjct: 163 KCDWKVDCRDSSDEIN----CTEICLHNE--FSCGNGECIPRAYVCDHDN 206
Score = 64.7 bits (156), Expect = 2e-09
Identities = 44/149 (29%), Positives = 60/149 (40%), Gaps = 13/149 (8%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
+TC C + CI + + CDG+ DC D SDE P C C +E C +
Sbjct: 2820 RTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYC---TTHTCSSSEFQC-ASGR 2875
Query: 85 CVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQAD 144
C+P C+ DC D SDE C + C L + C DG C S + D
Sbjct: 2876 CIPQHWYCDQETDCFDASDEPASCGHSERTC--LADEFKC----DGGRC-IPSEWICDGD 2928
Query: 145 GKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
DE + +Q C +D F+C
Sbjct: 2929 NDCGDMSDEDKRHQCQNQNC--SDSEFLC 2955
Score = 56.2 bits (134), Expect = 7e-07
Identities = 49/193 (25%), Positives = 64/193 (33%), Gaps = 49/193 (25%)
Query: 2469 AVANDTNSCELS-PCRINNG--GCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCR 2525
A N + C+ CR ++ C ++CL H SC G + C N
Sbjct: 156 ACYNTSQKCDWKVDCRDSSDEINCTEICL-----HNEFSCGNGECIPRAYVCDHDNDCQD 210
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWC 2585
DE C C + TC +GRC+ C
Sbjct: 211 GSDEHACNYPTCGGYQFTC-----------------------------PSGRCIYQNWVC 241
Query: 2586 NGADDCGDGSDEIPCNK-----TACGVGEFRC-RDGTCIGNSSRCNQFVDCEDASDEMN- 2638
+G DDC D DE C C E+ C G CI C+ +DC DE N
Sbjct: 242 DGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNT 301
Query: 2639 -----CSATDCSS 2646
CS T CS+
Sbjct: 302 STGKYCSMTLCSA 314
Score = 47.4 bits (111), Expect = 3e-04
Identities = 48/204 (23%), Positives = 84/204 (41%), Gaps = 45/204 (22%)
Query: 4342 NKCSRCLEGACVVNKQSGDVTCNCTDGR--VAPSCLTCVG------------HCSNGGSC 4387
N C + C++ + G +C C G + S C C +GG+C
Sbjct: 4332 NLCKQICSHLCLL--RPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNC 4389
Query: 4388 TMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIA-SILIPLLLLLLLVLVAGVVFWYKR 4446
+ +P+C+CP TG CE PG A ++L+ +LL++++ +A F++ R
Sbjct: 4390 YFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYR 4449
Query: 4447 R-----------------VQGAKGFQHQRMTNGA-MNVEIGNPTYKMYEGGEPD---DVG 4485
R V+ ++ +GA +N++IG G P+ D
Sbjct: 4450 RTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIG------VSGFGPETAIDRS 4503
Query: 4486 GLLDADFALDPDK-PTNFTNPVYA 4508
+ DF ++ K P F NP+Y+
Sbjct: 4504 MAMSEDFVMEMGKQPIIFENPMYS 4527
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 1121 bits (2899), Expect = 0.0
Identities = 639/1692 (37%), Positives = 946/1692 (55%), Gaps = 113/1692 (6%)
Query: 852 PQCQPGE--FACANSR-----CIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCEN 904
P+C G F CA S CI +W+CDGDNDC D+SDE C TC F C+N
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG--CILPTCSPLDFHCDN 80
Query: 905 NRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDR 964
+CI W+CDGDNDC + DE + C R C ++F C +G CI W CD D+DCGD
Sbjct: 81 GKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDN 138
Query: 965 SDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHS-----CSSTQ 1019
SDE C C +F C++G CI +W CD D DC D SDE C + C+ +
Sbjct: 139 SDEQ--CDMRKCSD-KEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEE 195
Query: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
F+C GRCI + + CDGD+DCGD+SDE+ +C++ C + EF C GLCI
Sbjct: 196 FQCAYGRCILDIYHCDGDDDCGDWSDES--DCSSHQP-----CRSGEFMCD-SGLCINAG 247
Query: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
WRCDGD DC D SDE++C T +C +F C S RC+ +W CDG++DC DNSDEEN
Sbjct: 248 WRCDGDADCDDQSDERNC--TTSMCTAE-QFRCH-SGRCVRLSWRCDGEDDCADNSDEEN 303
Query: 1140 CESLA---CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG--ELC------DQCSLN 1188
CE+ C C N C+ KLC+G +DCGD SDE + C + C++N
Sbjct: 304 CENTGSPQCALDQFLCWNGR--CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
Query: 1189 NGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSC 1248
NGGC+ C + G + C+C G L D HTCQ + CA+ CSQ C ++ + +C C
Sbjct: 362 NGGCAQKCQMVRG-AVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC 420
Query: 1249 YEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQ 1308
G+ L PD SC++L P +P ++F+NR +IR++ H+ +Y++L+ L N IALDFH +
Sbjct: 421 ETGYELRPDRRSCKALGP-EPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRR 479
Query: 1309 SALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQI 1368
++W+DV D+I R L NG+ + E V+ GL +P GLAVDW+ +YW +S +I
Sbjct: 480 ELVFWSDVTLDRILRANL--NGS--NVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRI 535
Query: 1369 EVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHR 1428
EVA LDG R LL ++E PRAIAL P +G ++WTDW + PRIEA+SM G+GRR +
Sbjct: 536 EVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW-GNTPRIEASSMDGSGRRII-- 592
Query: 1429 ETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYG 1488
WPNGLT+DY +R+ W+DA+ I A DGS V+ + L HPFA+T++
Sbjct: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFE 650
Query: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548
+YWTDW T ++ ANK+TG N +++ P D+ HP RQP N C N G
Sbjct: 651 DSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN--NGG 708
Query: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIIS 1608
C+HLCL + + +CACP + + KFLL+AR+M+IR + D + +
Sbjct: 709 CTHLCLPS-GQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDV- 766
Query: 1609 FTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWV 1668
+ D+ + LD+D+R+ VYW+DV T I RA +GTG E VV L + GLA+DWV
Sbjct: 767 IPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWV 826
Query: 1669 SRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD---GDNI 1724
+ L+WT D +I VA DGS + ++ + L++P +VV P+ G +YWTD I
Sbjct: 827 TNKLYWT--DAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKI 884
Query: 1725 SMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMR 1783
A MD S R ++ S P GLAID+ +LYW +G TI LDGS +V+ +
Sbjct: 885 ERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVL--IG 942
Query: 1784 SQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLD 1843
SQL L + G++++W D ++ + + + G L+ + +M + V+ +
Sbjct: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFH---RRR 999
Query: 1844 HKGTNPCSVNNGDCSQLCLPTSETTR-SCMCTAGYSLRSGQQACE-GVGSFLLYSVHEGI 1901
+ PC++ NG CS LCL + + SC C G +L S + C G+ SFL+++ I
Sbjct: 1000 PPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDI 1059
Query: 1902 RGIPLDPNDKSDALVPVSGT---SLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED 1958
R + LD +D +VP++ T ++A+G+D + +YW D L ISRA D + ED
Sbjct: 1060 RMVSLDIPYFADVVVPINITMKNTIAIGVD--PQEGKVYWSDSTLHRISRANLDGSQHED 1117
Query: 1959 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPE 2018
++T G+ +G+AVD I +YWTD G + IEV L+GS R V++ Q LD PRAI ++ E
Sbjct: 1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHE 1177
Query: 2019 KGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIER 2078
G+++WT+WG+ ++ERS +DG++R VL+N ++ WPNG++VD +L W DA T++IE
Sbjct: 1178 MGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEA 1237
Query: 2079 IDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
DL G NR ++S + +++ + +IYW+D SI R K ++ + +R+ +
Sbjct: 1238 ADL-NGANRHTLVSP-VQHPYGLTLLDSYIYWTD--WQTRSIHRADKGTGSNVILVRSNL 1293
Query: 2139 GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGM-LAEDGASC-RE 2196
L D++ +R + G N C NGGC LCL R G +CAC G+ L DG +C
Sbjct: 1294 -PGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSG-FSCACPTGIQLKGDGKTCDPS 1351
Query: 2197 YAGYLLYSERTILKSIHL--SDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNR 2254
YLL+S R ++ I L SD +++ PV PE + NVI+L +D +
Sbjct: 1352 PETYLLFSSRGSIRRISLDTSDHTDVHVPV-----PE-LNNVISLDYD-------SVDGK 1398
Query: 2255 IFFSDIHFGNIQQINDDGSRRITIV-ENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
++++D+ I++ + +GS T++ + + +GLA LYWT R+T++
Sbjct: 1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTD-----TGRNTIE 1453
Query: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
+R R+ +I S D+ PRA + + +FWT+W I RA L G+ LI
Sbjct: 1454 ASRLDGSCRKVLINNSLDE-PRAIAVFPRKGYLFWTDWG-HIAKIERANLDGSERKVLIN 1511
Query: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433
D+ PNGL +D+ ++Y+ DA LD+IE + +G R V++ S HPF L I+
Sbjct: 1512 TDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQDRWIY 1570
Query: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLC 2493
WTDW +++QR +K+ G N + + ++ + + I V + + C +NNGGC LC
Sbjct: 1571 WTDWQTKSIQRVDKYSGRNKETVLANV--EGLMDIIVVSPQRQTGTNACGVNNGGCTHLC 1628
Query: 2494 LLTHQGHVNCSC 2505
V C+C
Sbjct: 1629 FARASDFV-CAC 1639
Score = 617 bits (1590), Expect = e-175
Identities = 333/757 (43%), Positives = 429/757 (56%), Gaps = 61/757 (8%)
Query: 2587 GADDCGDGSDEIPCNKTACGVGEFRCR-----DGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
GA C G P + ACG F C + TCI +C+ DC D SDE C
Sbjct: 11 GALLCAHGLASSP--ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL 68
Query: 2642 TDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR-CPLNY 2700
CS L C+ C SWVCDG NDC D SDE+DCP PR C +
Sbjct: 69 PTCSP---------LDFHCDNGK-CIRRSWVCDGDNDCEDDSDEQDCP----PRECEEDE 114
Query: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
F C +G CI W CD ++DC DE + CS+ +F C + CI++ W CDG DC
Sbjct: 115 FPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCK 174
Query: 2761 DGSDEAAHCEGKT----CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNS 2816
DGSDE +C C F C C+ + + CDGD DC D +DES C +
Sbjct: 175 DGSDEE-NCPSAVPAPPCNLEEFQCAYGR-CILDIYHCDGDDDCGDWSDES---DCSSHQ 229
Query: 2817 TCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQW 2876
C EFMC + CI + CD D DC D SDE C C +FRC +GRC+ W
Sbjct: 230 PCRSGEFMCDSGLCINAGWRCDGDADCDDQSDER-NCTTSMCTAEQFRCHSGRCVRL-SW 287
Query: 2877 ECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 2936
CDGE+DC D SDE +C + A QFLC +GRC+ + LCNG +DCGD+SDE
Sbjct: 288 RCDGEDDCADNSDEE----NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Query: 2937 ------------RGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVD 2984
C++N GC+Q C+ ++ +C C G+RL +DG TC DV+
Sbjct: 344 SPQQNCRPRTGEENCNVNN------GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVN 397
Query: 2985 ECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNL 3044
EC+ CSQ C N+ G+++C C GY R D SCKA+ EP L+FANR +R++
Sbjct: 398 ECAEEGYCSQGCTNSEGAFQCWCETGYELRP-DRRSCKAL-GPEPVLLFANRIDIRQVLP 455
Query: 3045 DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNP 3104
S YTLL L NA+ALDF +R ++++W+DVT I R +LNGSNV+ + TGL +P
Sbjct: 456 HRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLD--RILRANLNGSNVEEVVSTGLESP 513
Query: 3105 DGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDW 3164
GLAVDWV LYW D G IEV+ L+GA+R VL+ L +PRA+ + G +YWTDW
Sbjct: 514 GGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDW 573
Query: 3165 GDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRH 3224
G+ I MDGS R +I DT + WPNGLT+DY R+YW DA+ IE A+LDGS+R
Sbjct: 574 GNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRK 633
Query: 3225 VVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHAL 3284
V+SQ +PH FA+T+FED +YWTDW TKSIN A+K TG N+ ++ + LH PMD+H H
Sbjct: 634 AVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQ 693
Query: 3285 RQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNF 3321
RQP N C NNGGC++LCL S G + CACPT F
Sbjct: 694 RQPAGKNR-CGDNNGGCTHLCLPS-GQNYTCACPTGF 728
Score = 538 bits (1385), Expect = e-152
Identities = 329/980 (33%), Positives = 518/980 (52%), Gaps = 48/980 (4%)
Query: 1546 QGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF--KKFLLYARQMEIRGVDLDAPYY 1603
+G CS C N C C +L D +C + LL+A +++IR V Y
Sbjct: 402 EGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEY 460
Query: 1604 NYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGL 1663
+++ +++N LD+ R + V+WSDV I RA +NG+ VE VVS L + GL
Sbjct: 461 TLLLN----NLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGL 516
Query: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDGD 1722
AVDWV L+WT D+ +I VA LDG+ + ++ Q LE+P + +HP+ G +YWTD
Sbjct: 517 AVDWVHDKLYWT--DSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG 574
Query: 1723 N---ISMANMDGSNRTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778
N I ++MDGS R ++ P GL ID+ ++YW+ + +H I R NLDGS +
Sbjct: 575 NTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKA 634
Query: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838
+ + L A+ + D L+W D ++ + + +K G ++RN L M ++
Sbjct: 635 V--ISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNK--LHFPMDIHTL 690
Query: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVH 1898
Q G N C NNG C+ LCLP+ + +C C G+ S + + FLL++
Sbjct: 691 HPQRQPAGKNRCGDNNGGCTHLCLPSGQNY-TCACPTGFRKISSHACAQSLDKFLLFARR 749
Query: 1899 EGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED 1958
IR I D D SD ++P++ AV +D+ + +D +YW D+ TISRAK D T +E
Sbjct: 750 MDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEV 809
Query: 1959 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPE 2018
VV + G+A+DW+ +YWTD G D IEVA +GS R V+I + LD+PR I V P
Sbjct: 810 VVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPM 869
Query: 2019 KGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIER 2078
GY++WT+WG P+IER+ +D + R V+++ +++WPNG+++DY +LYW DA IE
Sbjct: 870 GGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEF 929
Query: 2079 IDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
L+ G R+V++ S F ++++ + IYW+D SI+ + D L+ +
Sbjct: 930 AGLD-GSKRKVLIGSQLPHPFGLTLYGERIYWTD--WQTKSIQSADRLTGLDRETLQENL 986
Query: 2139 GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQR-ACACAHGM-LAEDGASCRE 2196
L DI VF+R R + CA+ NGGC LCL +C C G+ L DG +C
Sbjct: 987 E-NLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSP 1045
Query: 2197 -YAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRI 2255
+L+++ R ++ + L D V P MKN IA+ D + G ++
Sbjct: 1046 GMNSFLIFARRIDIRMVSL-DIPYFADVVVPINIT--MKNTIAIGVDPQEG-------KV 1095
Query: 2256 FFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQ 2314
++SD I + N DGS+ I+ + + +GLA +YWT T+ I +D
Sbjct: 1096 YWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLD- 1154
Query: 2315 TRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEK 2374
G+ + V+ D PRA VL M+WT+W E + + R+ + G++ LI
Sbjct: 1155 ---GSMRK--VLVWQNLDSPRAIVLYHEMGFMYWTDWGE-NAKLERSGMDGSDRAVLINN 1208
Query: 2375 DIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFW 2434
++ PNGL +D + +L ++DA ++IE + +G++R+ ++ S HP+GL + +I+W
Sbjct: 1209 NLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYW 1267
Query: 2435 TDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCL 2494
TDW R++ RA+K GSN+ L+R ++P M + AV + + C NGGC LCL
Sbjct: 1268 TDWQTRSIHRADKGTGSNVILVRSNLPGL-MDMQAV-DRAQPLGFNKCGSRNGGCSHLCL 1325
Query: 2495 LTHQGHVNCSCRGGRILQDD 2514
G +C+C G L+ D
Sbjct: 1326 PRPSG-FSCACPTGIQLKGD 1344
Score = 521 bits (1343), Expect = e-147
Identities = 286/744 (38%), Positives = 392/744 (52%), Gaps = 53/744 (7%)
Query: 3449 PEVTCAPNQFQCSITK----RCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDS 3504
PE C + F C+++ CIP W CD DNDC D SDE C TC +F C D+
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDG-CILPTCSPLDFHC-DN 80
Query: 3505 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDN 3564
G+CI W CDG++DC D SDE ++C R CE +F C+N C+ W CD DNDCGDN
Sbjct: 81 GKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDN 138
Query: 3565 SDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC-----TPRCDMDQFQ 3619
SDE+ C R CS+ EF C++G CIA W CDGD DC DGSDE++C P C++++FQ
Sbjct: 139 SDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQ 197
Query: 3620 CKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDC 3679
C G CI + CD D DC D SDE C + + C EF C++ LC W+CDG+ DC
Sbjct: 198 CAYGRCILDIYHCDGDDDCGDWSDESDCSSH-QPCRSGEFMCDSGLCINAGWRCDGDADC 256
Query: 3680 GDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTT 3739
D SDE C +C + FRC + R C+ + +CDG D+C D +DEE+CE +
Sbjct: 257 DDQSDER--NCTTSMCTAEQ-FRCHSGR-CVRLSWRCDGEDDCADNSDEENCE--NTGSP 310
Query: 3740 HCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE---EDCSIDPKLTSCATNASICGDEA 3796
C +FLC N RC+ CN +DCGD SDE ++C +C N C +
Sbjct: 311 QCA-LDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKC 369
Query: 3797 RCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNF--M 3854
+ VR A C C +G+ CQD+NEC G CSQ C N++G C C +
Sbjct: 370 QMVRG--AVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELR 427
Query: 3855 KTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRV 3914
+CKA G E VL A+ +IR + P S Y E+ A+D H + V
Sbjct: 428 PDRRSCKALGPE-PVLLFANRIDIRQVLPHR--SEYTLLLNNLENAI--ALDFHHRRELV 482
Query: 3915 YWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYW 3974
+W++ I +N + ++ V+ +GL+ P G+A+DWV +YW
Sbjct: 483 FWSDVTLDRI-----------LRANLNGSNVEEVVS----TGLESPGGLAVDWVHDKLYW 527
Query: 3975 TDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGT 4034
TDSG IEVA + G +RK L+ +++P AI + P+ GT+YW+DWGN P+IE ++MDG+
Sbjct: 528 TDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGS 587
Query: 4035 LRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFS 4094
R + ++ WP GL +DY R+YW DAK VI L+G+ A +GL HPF+
Sbjct: 588 GRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR--KAVISQGLPHPFA 645
Query: 4095 IDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--D 4152
I VFED +Y + + +KF + L D+ H +QP N C +
Sbjct: 646 ITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN 705
Query: 4153 RKKCEWLCLLSPSGPVCTCPNGKR 4176
C LCL S C CP G R
Sbjct: 706 NGGCTHLCLPSGQNYTCACPTGFR 729
Score = 438 bits (1127), Expect = e-122
Identities = 276/827 (33%), Positives = 425/827 (51%), Gaps = 64/827 (7%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
C+ +QF C C+ WRCDGE DC D SDE E C + + +C ++ C C+
Sbjct: 270 CTAEQFRCHSG-RCVRLSWRCDGEDDCADNSDE--ENCENTGSPQCALDQFLCWNGR-CI 325
Query: 87 PMSRLCNGVQDCMDGSDEGP--HCRELQG----NCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
+LCNGV DC D SDE P +CR G N + GC C C C++ ++
Sbjct: 326 GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYR 385
Query: 141 LQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV 200
L DG TC+D +EC+ G CSQ CTN++G+F C C GY L+PD RSCKA + PV
Sbjct: 386 LTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKA----LGPEPV 441
Query: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVG-DSAAQTQLKCA 259
LL AN +I L T+ + A+DF + E V W V D + L +
Sbjct: 442 LLFANRIDIRQV-LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGS 500
Query: 260 RMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLD 319
+ + +S L +A+DW+ Y+ D RI V N +G LL
Sbjct: 501 NVEEV----------VSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLW 550
Query: 320 LELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSR 379
L P+ IAL P G +++TD+G P++E MDG R + D+ + +P+G+T+D R
Sbjct: 551 QNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610
Query: 380 LVYWADAYLDYIEVVDYEGKGRQTII-QGILIEHLYGLTVFENYLYATNSDNANAQQKTS 438
+YW DA IE + +G R+ +I QG + H + +TVFE+ LY T+ S
Sbjct: 611 RMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYWTD------WHTKS 662
Query: 439 VIRVNRFNSTEYQVV-TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLAN 497
+ N+F +++ ++ +H H +RQP ++ +N+ GGC+ +CL
Sbjct: 663 INSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNN-----GGCTHLCL--P 715
Query: 498 SHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIEN 557
S + TC C +GF S +C + + FL++ + IR + + + +IP+ +
Sbjct: 716 SGQNYTCACPTGFRKIS-SHACAQ-SLDKFLLFARRMD--IRRISFDTEDLSDDVIPLAD 771
Query: 558 LMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLY 617
+ + ALD+ + +Y+ D ++ I R K DGT +E ++ + + G+A+DW+ + LY
Sbjct: 772 VRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLY 831
Query: 618 WTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRG 677
WTD G + I VA + + +T LI + PR IVV+P+ G+MYWTDW PK
Sbjct: 832 WTDAGTDR-IEVANTDGSMRT--VLIWENLDRPRDIVVEPMGGYMYWTDWGASPK----- 883
Query: 678 RLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVY 737
+ERA MD S R + ++S + WPNGL++D + RLYW DA IE L+G+ RK++
Sbjct: 884 -IERAGMDASGRQVIISS-NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI 941
Query: 738 EGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDA 797
G +L H FGL +G ++WT++++ S+ +R G T L+ + +I ++
Sbjct: 942 -GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRET---LQENLENLMDIHVFHR 997
Query: 798 QQQQVGTNKCRVNNGGCSSLCLATPGSR--QCACAEDQVLDADGVTC 842
++ V T C + NGGCS LCL +P C C L +DG TC
Sbjct: 998 RRPPVST-PCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
Score = 366 bits (940), Expect = e-100
Identities = 225/677 (33%), Positives = 363/677 (53%), Gaps = 37/677 (5%)
Query: 1848 NPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIP 1905
N C+ G CSQ C SE C C GY LR +++C+ +G LL++ IR +
Sbjct: 397 NECA-EEGYCSQGCT-NSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL 454
Query: 1906 LDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIG 1965
+S+ + ++ A+ +DFH + ++W D+ L I RA + + E+VV+ G+
Sbjct: 455 ---PHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLE 511
Query: 1966 RVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWT 2025
G+AVDW+ +YWTD G IEVA L+G+ R V++ Q L+KPRAI +HP +G ++WT
Sbjct: 512 SPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWT 571
Query: 2026 EWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGE 2085
+WG PRIE S +DG+ R ++ + + WPNG+++DY ++YW DA+ IER +L+ G
Sbjct: 572 DWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLD-GS 630
Query: 2086 NREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDI 2145
+R+ V+S F+++VFED +YW+D H SI +K + +R + + DI
Sbjct: 631 HRKAVISQGLPHPFAITVFEDSLYWTD-WHTK-SINSANKFTGKNQEIIRNKLHFPM-DI 687
Query: 2146 KVFNRDRQ-KGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAG-YLLY 2203
+ RQ G N C NGGC LCL G+ CAC G +C + +LL+
Sbjct: 688 HTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY-TCACPTGFRKISSHACAQSLDKFLLF 746
Query: 2204 SERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFG 2263
+ R ++ I D +L+ V P D +++ +AL +D R + ++++D+
Sbjct: 747 ARRMDIRRISF-DTEDLSDDVIPLAD---VRSAVALDWDSR-------DDHVYWTDVSTD 795
Query: 2264 NIQQINDDGSRRITIVE-NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFER 2322
I + DG+ + +V+ ++ S GLA + LYWT T I D +
Sbjct: 796 TISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGS------M 849
Query: 2323 ETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGL 2382
TV+ D PR V++ M+WT+W P I RA + + +I ++ PNGL
Sbjct: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDASGRQVIISSNLTWPNGL 908
Query: 2383 AIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAV 2442
AID+ +++LY++DA + IE DGS R V++ S+ HPFGL +YGE I+WTDW +++
Sbjct: 909 AIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSI 968
Query: 2443 QRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLT-HQGHV 2501
Q A++ G + + L+ ++ + + I V + +PC + NGGC LCL + +
Sbjct: 969 QSADRLTGLDRETLQENL--ENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
Query: 2502 NCSCRGG-RILQDDLTC 2517
+C+C G +L D TC
Sbjct: 1027 SCTCPTGINLLSDGKTC 1043
Score = 339 bits (870), Expect = 3e-92
Identities = 218/692 (31%), Positives = 349/692 (50%), Gaps = 49/692 (7%)
Query: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
G C+ LC + ++ C C G+ S A + +D+ LL A +I
Sbjct: 707 GGCTHLCLPSGQNYTCACPTGFR----KISSHACAQSLDK--FLLFARRMDIRRISFDTE 760
Query: 218 QVS--TITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
+S I R A+D+ ++ V W V + A+ G + +
Sbjct: 761 DLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDT----ISRAKWDGTG-----QEVVV 811
Query: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
SL +AIDW+T Y+ D DRI V N +G L+ L P+ I ++P G
Sbjct: 812 DTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGG 871
Query: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
+++TD+G PK+ER MD R ++ S + +P+G+ +D S+ +YWADA + IE
Sbjct: 872 YMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAG 931
Query: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTR 455
+G R+ +I G + H +GLT++ +Y T+ + Q + ++R E
Sbjct: 932 LDGSKRKVLI-GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQE-----N 985
Query: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
++ +H++H+RR P A EN GGCS +CL + + +C C +G +L SD
Sbjct: 986 LENLMDIHVFHRRRPPVSTPCAMEN------GGCSHLCLRSPNPSGFSCTCPTGINLLSD 1039
Query: 516 GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIE-NLMNPRALDFHAETGFIY 574
GK+C P FL++ R IR + + + ++PI + N A+ + G +Y
Sbjct: 1040 GKTC-SPGMNSFLIF--ARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVY 1096
Query: 575 FADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEK 634
++D+T + I R +DG++ E I+ G+ +G+AVD +G +YWTD G + I V L+
Sbjct: 1097 WSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNR-IEVGNLD- 1154
Query: 635 AAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT 694
RK L+ + PRAIV+ G+MYWTDW E+ K LER+ MDGS R + +
Sbjct: 1155 -GSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAK------LERSGMDGSDRAVLI- 1206
Query: 695 SKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNY 754
+ + WPNGL++D + +L W DA +RIE LNG +R + + H +GL +Y
Sbjct: 1207 NNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVS--PVQHPYGLTLLDSY 1264
Query: 755 LFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGC 814
++WT++++ S++R ++G G V L+RS P + +++ D + Q +G NKC NGGC
Sbjct: 1265 IYWTDWQTRSIHRADKGTGS---NVILVRSNLPGLMDMQAVD-RAQPLGFNKCGSRNGGC 1320
Query: 815 SSLCLATPGSRQCACAEDQVLDADGVTCLANP 846
S LCL P CAC L DG TC +P
Sbjct: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSP 1352
Score = 319 bits (818), Expect = 3e-86
Identities = 215/699 (30%), Positives = 344/699 (49%), Gaps = 57/699 (8%)
Query: 158 GTCSQLCTNTDG--SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215
G CS LC + F C C G L D ++C L+ A +I L
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF-----LIFARRIDIRMVSLD 1065
Query: 216 ---GAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHT 272
A V + + T A+ V W DS ++ A + G +H
Sbjct: 1066 IPYFADVVVPINITMKNTIAIGVDPQEGKVYW---SDSTLH-RISRANLDG-----SQHE 1116
Query: 273 INISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDP 332
I+ L + +A+D + Y+ D +RI V N +G L+ L +P+ I L
Sbjct: 1117 DIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
Query: 333 AMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIE 392
MG +++TD+G+ K+ER MDG +R L+++ + +P+G+T+D S + WADA+ + IE
Sbjct: 1177 EMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIE 1236
Query: 393 VVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQV 452
D G R T++ + +H YGLT+ ++Y+Y T+ Q S+ R ++ + +
Sbjct: 1237 AADLNGANRHTLVSPV--QHPYGLTLLDSYIYWTD------WQTRSIHRADKGTGSNV-I 1287
Query: 453 VTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSL 512
+ R + G + + R + + C + + GGCS +CL S +C C +G L
Sbjct: 1288 LVRSNLPGLMDMQAVDRAQPLGFNKCGS----RNGGCSHLCLPRPS--GFSCACPTGIQL 1341
Query: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
DGK+C P E +L++ G IR + + + +P+ L N +LD+ + G
Sbjct: 1342 KGDGKTCD-PSPETYLLFSSR--GSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGK 1398
Query: 573 IYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARL 632
+Y+ D +I R ++G+ ET++ G+ +G+AVDW+ NLYWTD G + TI +RL
Sbjct: 1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG-RNTIEASRL 1457
Query: 633 EKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF 692
+ RK LI + PRAI V P G+++WTDW ++ERA +DGS R +
Sbjct: 1458 D--GSCRKVLINNSLDEPRAIAVFPRKGYLFWTDW------GHIAKIERANLDGSERKVL 1509
Query: 693 VTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHG 752
+ + + WPNGL+LD R+YWVDA DRIE+ LNG R+++ ++H F L
Sbjct: 1510 INT-DLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS--HVSHPFALTQQD 1566
Query: 753 NYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNG 812
+++WT++++ S+ R+++ G TV I + + Q+Q GTN C VNNG
Sbjct: 1567 RWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVV----SPQRQTGTNACGVNNG 1622
Query: 813 GCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPP 851
GC+ LC A CAC + + D C P VPP
Sbjct: 1623 GCTHLCFARASDFVCACPD----EPDSRPCSLVPGLVPP 1657
Score = 307 bits (787), Expect = 1e-82
Identities = 155/343 (45%), Positives = 210/343 (61%), Gaps = 12/343 (3%)
Query: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDG---SN 3048
C+ C+ + +Y C C G+ R H+C D+ FL+FA R +R+++ D S+
Sbjct: 709 CTHLCLPSGQNYTCACPTGF--RKISSHACAQSLDK--FLLFARRMDIRRISFDTEDLSD 764
Query: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
+ + +AVALD+D R+ +YWTDV+T I R +G+ +V+ T L +P GLA
Sbjct: 765 DVIPLADVRSAVALDWDSRDDHVYWTDVSTD--TISRAKWDGTGQEVVVDTSLESPAGLA 822
Query: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3168
+DWV LYW D G D IEV+ +G+ RTVL+ L PR +VV+ GY+YWTDWG
Sbjct: 823 IDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASP 882
Query: 3169 LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS 3228
I R GMD S R VI+ + +TWPNGL +DY ++R+YWADA IEFA LDGS R V++
Sbjct: 883 KIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIG 942
Query: 3229 QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD 3288
+PH F LTL+ + +YWTDW+TKSI A + TG ++ L L MD+HVFH R P
Sbjct: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPP- 1001
Query: 3289 VPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYLGSDGRTC 3330
+ PC + NGGCS+LCL SP G C CPT L SDG+TC
Sbjct: 1002 -VSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC 1043
Score = 291 bits (745), Expect = 1e-77
Identities = 155/408 (37%), Positives = 210/408 (51%), Gaps = 50/408 (12%)
Query: 3334 CTASQFVCKNDK-----CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTN 3388
C S F C CIP W+CD ++DCGDHSDE C C P F C G C
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDED-GCILPTCSPLDFHCDNGKCIR 85
Query: 3389 PAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
+++CDGDNDC+D+SDE +C C +F C N CI ++ C+G ++CGD DE+ C
Sbjct: 86 RSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN-GYCIRSLWHCDGDNDCGDNSDEQ-C 143
Query: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE---PANCTQMTCGVDEFRCKDSG 3505
C+ +F+CS CI W CD D DC DGSDE P+ C ++EF+C G
Sbjct: 144 DMRKCSDKEFRCS-DGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCA-YG 201
Query: 3506 RCIPARWKCDGEDDCGDGSDEPKEEC-DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDN 3564
RCI + CDG+DDCGD SDE +C + C +F C + C+ W+CD D DC D
Sbjct: 202 RCILDIYHCDGDDDCGDWSDE--SDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQ 259
Query: 3565 SDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC----TPRCDMDQFQC 3620
SDE +CT C+ +F C +GRC+ W+CDG+ DCAD SDE++C +P+C +DQF C
Sbjct: 260 SDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLC 319
Query: 3621 KSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCG 3680
+G CI R C+ DC D SDE Q N C+P GE++C
Sbjct: 320 WNGRCIGQRKLCNGVNDCGDNSDESP-------------QQN---CRPRT----GEENCN 359
Query: 3681 DNSDENPEEC----ARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGD 3724
N+ ++C C + +R D G C + C +
Sbjct: 360 VNNGGCAQKCQMVRGAVQCTCHTGYRLTED------GHTCQDVNECAE 401
Score = 282 bits (721), Expect = 6e-75
Identities = 161/392 (41%), Positives = 219/392 (55%), Gaps = 57/392 (14%)
Query: 2942 NECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHG 3001
N+C SR GCS C GF C C G +LK DG+TC
Sbjct: 1311 NKCGSRN-GGCSHLCLPRPSGFSCACPTGIQLKGDGKTC--------------------- 1348
Query: 3002 SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYT---LLKQGLNN 3058
DP E +L+F++R +R+++LD S++T + LNN
Sbjct: 1349 ---------------DP-------SPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
Query: 3059 AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYW 3118
++LD+D + +Y+TDV +IRR LNGSN++ + GL DGLAVDWV NLYW
Sbjct: 1387 VISLDYDSVDGKVYYTDVFL--DVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYW 1444
Query: 3119 CDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGS 3178
D GR+TIE S+L+G+ R VL+++ L EPRA+ V + GYL+WTDWG + I R +DGS
Sbjct: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
Query: 3179 SRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALT 3238
R V+++T + WPNGLTLDY T RIYW DA D IE A L+G R V++S + H FALT
Sbjct: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSH-VSHPFALT 1563
Query: 3239 LFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNN 3298
+ ++YWTDW+TKSI R K +G NK +++ + MD+ V RQ + C VNN
Sbjct: 1564 QQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ--TGTNACGVNN 1621
Query: 3299 GGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC 3330
GGC++LC + CACP D R C
Sbjct: 1622 GGCTHLC-FARASDFVCACPDE----PDSRPC 1648
Score = 258 bits (658), Expect = 1e-67
Identities = 142/354 (40%), Positives = 204/354 (57%), Gaps = 20/354 (5%)
Query: 2991 PCSQRCINTHGSYKCLCVEGYAPRGGD---PHSCKAVTDEEP-------FLIFANRYYLR 3040
P S C +G LC+ P G P ++D + FLIFA R +R
Sbjct: 1001 PVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIR 1060
Query: 3041 KLNLDGSNYTLLKQGLN----NAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVL 3096
++LD + + +N N +A+ D +E +YW+D T I R +L+GS + +
Sbjct: 1061 MVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLH--RISRANLDGSQHEDI 1118
Query: 3097 HRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQN 3156
TGL DGLAVD +G +YW D G + IEV L+G+ R VLV L PRA+V+ +
Sbjct: 1119 ITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM 1178
Query: 3157 GYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFA 3216
G++YWTDWG+++ + R GMDGS R+V+++ + WPNGLT+D + ++ WADA + IE A
Sbjct: 1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
Query: 3217 SLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPM 3276
L+G+NRH ++S + H + LTL + Y+YWTDW+T+SI+RA K TG+N L+ S L M
Sbjct: 1239 DLNGANRHTLVS-PVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLM 1297
Query: 3277 DLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC 3330
D+ R + + C NGGCS+LCL P G CACPT L DG+TC
Sbjct: 1298 DMQAVD--RAQPLGFNKCGSRNGGCSHLCLPRP-SGFSCACPTGIQLKGDGKTC 1348
Score = 190 bits (482), Expect = 3e-47
Identities = 112/312 (35%), Positives = 148/312 (47%), Gaps = 49/312 (15%)
Query: 2490 QDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC------------ANGEC 2537
+D C+L ++ C G+ ++ C N DE +C NG C
Sbjct: 63 EDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYC 122
Query: 2538 INFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDE 2597
I CDG C D SDE+ C+ R+C +CS+G C++ +C+G DC DGSDE
Sbjct: 123 IRSLWHCDGDNDCGDNSDEQ---CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Query: 2598 IPCNKTA----CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVK 2653
C C + EF+C G CI + C+ DC D SDE +DCSS+
Sbjct: 180 ENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE-----SDCSSH------ 228
Query: 2654 GVLFQPCER------TSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR 2707
QPC + LC W CDG DC D SDER+C C F C SGR
Sbjct: 229 ----QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC---TTSMCTAEQFRCHSGR 281
Query: 2708 CIPMSWTCDKEDDCEHGEDETHCNKF----CSEAQFECQNHRCISKQWLCDGSDDCGDGS 2763
C+ +SW CD EDDC DE +C C+ QF C N RCI ++ LC+G +DCGD S
Sbjct: 282 CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNS 341
Query: 2764 DEA--AHCEGKT 2773
DE+ +C +T
Sbjct: 342 DESPQQNCRPRT 353
Score = 189 bits (480), Expect = 5e-47
Identities = 123/379 (32%), Positives = 182/379 (48%), Gaps = 43/379 (11%)
Query: 3818 GQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNE 3877
G+ C D N G C+ LC + + C+C F K + A+ + +L+ A +
Sbjct: 698 GKNRCGDNN-----GGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLF-ARRMD 751
Query: 3878 IRSLFPGHPHSAYEQAFQGDESVRID------AMDVHVKAGRVYWTNWHTGTISYRSLPP 3931
IR + +++ D+ + + A+D + VYWT+ T TIS
Sbjct: 752 IRRI-------SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG 804
Query: 3932 AAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGEN 3991
+ + L+ P G+AIDWV +YWTD+G D IEVA G
Sbjct: 805 TGQEVVVD---------------TSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSM 849
Query: 3992 RKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLA 4051
R LI +D P IVV+P+ G MYW+DWG PKIE A MD + R+ ++ N+ WP GLA
Sbjct: 850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLA 909
Query: 4052 VDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNR 4111
+DY ++RLYWADA + I L+G+ V S+ L HPF + ++ + IY +
Sbjct: 910 IDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKS 967
Query: 4112 VFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLS--PSGP 4167
+ + L L + D+ ++H+ ++P V+ PC + C LCL S PSG
Sbjct: 968 IQSADRLTGLDRETLQENLENLMDIHVFHR-RRPPVSTPCAMENGGCSHLCLRSPNPSGF 1026
Query: 4168 VCTCPNGKRL--DNGTCVP 4184
CTCP G L D TC P
Sbjct: 1027 SCTCPTGINLLSDGKTCSP 1045
Score = 173 bits (438), Expect = 4e-42
Identities = 116/375 (30%), Positives = 172/375 (45%), Gaps = 29/375 (7%)
Query: 3826 NEC-LRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSL-FP 3883
N+C R G CS LC G C+C + + S L + IR +
Sbjct: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLD 1370
Query: 3884 GHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRR 3943
H+ E + ++D G+VY+T+ I L + T R
Sbjct: 1371 TSDHTDVHVPVP--ELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGR--- 1425
Query: 3944 QIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEP 4003
GLK G+A+DWVA N+YWTD+GR+ IE +++ G RK LI+ +DEP
Sbjct: 1426 ------------GLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEP 1473
Query: 4004 HAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWAD 4063
AI V P +G ++W+DWG+ KIE A +DG+ R+ L+ ++ WP GL +DY R+YW D
Sbjct: 1474 RAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVD 1533
Query: 4064 AKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPL 4123
A L I S LNG V +SHPF++ + +IY + + ++ K+
Sbjct: 1534 AHLDRIESADLNGKLRQVLVSH---VSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNK 1590
Query: 4124 VNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNGKRLDNGT 4181
+ + D+++ +Q TN C + C LC S VC CP+ D+
Sbjct: 1591 ETVLANVEGLMDIIVVSPQRQTG-TNACGVNNGGCTHLCFARASDFVCACPD--EPDSRP 1647
Query: 4182 CVPVPSPTPPPDAPR 4196
C VP PP APR
Sbjct: 1648 CSLVPGLVPP--APR 1660
Score = 172 bits (435), Expect = 9e-42
Identities = 113/333 (33%), Positives = 152/333 (45%), Gaps = 34/333 (10%)
Query: 3286 QPDVPNHPCKVNNGGCSN-LCLLSP---GGGHKCACPTNFYLGSDGRTCVSNCTASQFVC 3341
+ D P C+ + C N C+ S G + C SD + + C+ +F C
Sbjct: 102 EQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGD------NSDEQCDMRKCSDKEFRC 155
Query: 3342 KNDKCIPFWWKCDTEDDCGDHSDE---PPDCPEFKCRPGQFQCSTGICTNPAFICDGDND 3398
+ CI W CD + DC D SDE P P C +FQC+ G C + CDGD+D
Sbjct: 156 SDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDD 215
Query: 3399 CQDNSDEANCDIH-VCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQ 3457
C D SDE++C H C +F C ++ CI +RC+G +C D DER+C C Q
Sbjct: 216 CGDWSDESDCSSHQPCRSGEFMC-DSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQ 274
Query: 3458 FQCSITKRCIPRVWVCDRDNDCVDGSDEP--ANCTQMTCGVDEFRCKDSGRCIPARWKCD 3515
F+C + RC+ W CD ++DC D SDE N C +D+F C +GRCI R C+
Sbjct: 275 FRCH-SGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCW-NGRCIGQRKLCN 332
Query: 3516 GEDDCGDGSDE-PKEECDERTCEPYQFRCKNNRC------VPGRWQCDYDNDCGDNSDEE 3568
G +DCGD SDE P++ C RT E N C V G QC D
Sbjct: 333 GVNDCGDNSDESPQQNCRPRTGEE-NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGH 391
Query: 3569 SCTP-RPCSESEFSCANGRCIAGRWKCDGDHDC 3600
+C C+E G C G +G C
Sbjct: 392 TCQDVNECAE------EGYCSQGCTNSEGAFQC 418
Score = 157 bits (396), Expect = 3e-37
Identities = 112/365 (30%), Positives = 165/365 (45%), Gaps = 33/365 (9%)
Query: 3832 GTCSQLC--NNTKGGHLCSCAR--NFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPH 3887
G CS LC + G C+C N + TC + + L A +IR + P+
Sbjct: 1011 GGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSF--LIFARRIDIRMVSLDIPY 1068
Query: 3888 SAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDR 3947
A A+ V + G+VYW++ +T +R R
Sbjct: 1069 FADVVVPINITMKNTIAIGVDPQEGKVYWSD-----------------STLHRISRANLD 1111
Query: 3948 GVTHLNI--SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHA 4005
G H +I +GL+ G+A+D + VYWTD+G + IEV + G RK L+ +D P A
Sbjct: 1112 GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRA 1171
Query: 4006 IVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAK 4065
IV+ G MYW+DWG + K+E + MDG+ R L+ +N+ WP GL VD + +L WADA
Sbjct: 1172 IVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAH 1231
Query: 4066 LSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVN 4125
I + LNG + + HP+ + + + YIY + + + K S ++
Sbjct: 1232 TERIEAADLNGANRHTLVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVIL 1288
Query: 4126 LTGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPNGKRL--DNGT 4181
+ L D+ QP N C + C LCL PSG C CP G +L D T
Sbjct: 1289 VRSNLPGLMDMQAV-DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKT 1347
Query: 4182 CVPVP 4186
C P P
Sbjct: 1348 CDPSP 1352
Score = 147 bits (370), Expect = 3e-34
Identities = 92/275 (33%), Positives = 125/275 (45%), Gaps = 27/275 (9%)
Query: 3315 CACPTNFYLGSDGRTCVSN-----CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDC 3369
C T+ GSD C S C +F C +CI + CD +DDCGD SDE
Sbjct: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
Query: 3370 PEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPG 3429
CR G+F C +G+C N + CDGD DC D SDE NC +C QF+C ++ RC+
Sbjct: 227 SHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRL 285
Query: 3430 IFRCNGQDNCGDGEDERDCPEV---TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE- 3485
+RC+G+D+C D DE +C CA +QF C RCI + +C+ NDC D SDE
Sbjct: 286 SWRCDGEDDCADNSDEENCENTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDES 344
Query: 3486 -PANCTQMT----CGVDEFRCKDSGRCIPARWKCDGE-----DDCGDGSDEPKEECDERT 3535
NC T C V+ C + + +C + G + E +E
Sbjct: 345 PQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY 404
Query: 3536 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
C C N+ G +QC + D SC
Sbjct: 405 CSQ---GCTNSE---GAFQCWCETGYELRPDRRSC 433
Score = 129 bits (323), Expect = 9e-29
Identities = 97/357 (27%), Positives = 162/357 (45%), Gaps = 30/357 (8%)
Query: 151 FDEC-SVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNI 209
F++C S G CS LC F C C G L+ D ++C E LL ++ +I
Sbjct: 1310 FNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETY-----LLFSSRGSI 1364
Query: 210 LATYLSGAQVSTI--TPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGF 267
L + + + ++D+ + V + V L R L G
Sbjct: 1365 RRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVF-------LDVIRRADLNGS 1417
Query: 268 VDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKG 327
E I L + +A+DW+ N Y+ D + I +G L++ L P+
Sbjct: 1418 NMETVIGRGLKT--TDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRA 1475
Query: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
IA+ P G +F+TD+G I K+ER ++DG R L+++ + +P+G+TLD +R +YW DA+
Sbjct: 1476 IAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAH 1535
Query: 388 LDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNS 447
LD IE D GK RQ ++ + H + LT + ++Y T+ Q S+ RV++++
Sbjct: 1536 LDRIESADLNGKLRQVLVSH--VSHPFALTQQDRWIYWTD------WQTKSIQRVDKYSG 1587
Query: 448 TEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTC 504
+ V + G + I Q + ++AC + GGC+ +C S C
Sbjct: 1588 RNKETVL-ANVEGLMDIIVVSPQRQTGTNACGVNN----GGCTHLCFARASDFVCAC 1639
Score = 117 bits (294), Expect = 2e-25
Identities = 91/296 (30%), Positives = 124/296 (41%), Gaps = 41/296 (13%)
Query: 2472 NDTNSCELSPCRINNGGCQD-LCLLTH-QGHVNCSCRGGRILQDDLTC-RAVNSSCRAQD 2528
N C++ C C D C+ H + C+ G D+ C AV + +
Sbjct: 138 NSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDG---SDEENCPSAVPAPPCNLE 194
Query: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR-CKKTFRQCSNGRCVSNMLWCNG 2587
EF+CA G CI CDG C D SDE S C+S + C+ C +G C++ C+G
Sbjct: 195 EFQCAYGRCILDIYHCDGDDDCGDWSDE--SDCSSHQPCRSGEFMCDSGLCINAGWRCDG 252
Query: 2588 ADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSY 2647
DC D SDE C + C +FRC G C+ S RC+ DC D SDE NC T
Sbjct: 253 DADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTG---- 308
Query: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE---RDC-PGVKRPRCPLNYFAC 2703
+ L Q C +C+G NDCGD SDE ++C P C +N C
Sbjct: 309 ---SPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGC 365
Query: 2704 PSG----------------RCIPMSWTCDKEDDCEHGEDETHCNKFC--SEAQFEC 2741
R TC ++C +E +C++ C SE F+C
Sbjct: 366 AQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC---AEEGYCSQGCTNSEGAFQC 418
Score = 65.9 bits (159), Expect = 9e-10
Identities = 54/173 (31%), Positives = 72/173 (41%), Gaps = 19/173 (10%)
Query: 12 LLSALVAA---AIDAPKTCSPKQFACR----DQITCISKGWRCDGERDCPDGSDEAPEIC 64
LL AL+ A A C F C + TCI W+CDG+ DC D SDE I
Sbjct: 9 LLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL 68
Query: 65 PQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQH-H 123
P C P + +C C+ S +C+G DC D SDE C + CQ+ +
Sbjct: 69 P-----TCSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDE-QDCPPRECEEDEFPCQNGY 121
Query: 124 CVPTL---DGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
C+ +L DG C + Q D + C D + G+C DG C
Sbjct: 122 CIRSLWHCDGDN-DCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDC 173
Score = 36.2 bits (82), Expect = 0.76
Identities = 42/179 (23%), Positives = 66/179 (36%), Gaps = 52/179 (29%)
Query: 4219 KCRCQPRYTGDKCELDQ-CWEHCRNGGTCAASPSGMPTC-----RCPTGFTGPKCTQQVC 4272
+C C P +C+ D C +H G +PTC C G KC ++
Sbjct: 41 ECTCIPAQW--QCDGDNDCGDHSDEDGCI------LPTCSPLDFHCDNG----KCIRR-- 86
Query: 4273 AGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC--------SGYC-ENFGTCQMAAD 4323
+ C ++ C + Q C R+C +GYC + C D
Sbjct: 87 SWVCDGDNDCEDDSDEQD------------CPPRECEEDEFPCQNGYCIRSLWHC----D 130
Query: 4324 GSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCV 4378
G C + +C++ KCS RC +G+C+ D +C DG +C + V
Sbjct: 131 GDNDCGDNS---DEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAV 186
Score = 35.0 bits (79), Expect = 1.7
Identities = 31/105 (29%), Positives = 41/105 (39%), Gaps = 21/105 (20%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAAS---PSGMPTCRCPT 4260
C C N+ P+ C+PR + C + N G CA G C C T
Sbjct: 331 CNGVNDCGDNSDESPQQNCRPRTGEENCNV--------NNGGCAQKCQMVRGAVQCTCHT 382
Query: 4261 GF----TGPKCTQ-QVCA--GYCANNSTCTVNQGNQPQCRCLPGF 4298
G+ G C CA GYC+ CT ++G QC C G+
Sbjct: 383 GYRLTEDGHTCQDVNECAEEGYCSQG--CTNSEG-AFQCWCETGY 424
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 816 bits (2107), Expect = 0.0
Identities = 482/1397 (34%), Positives = 764/1397 (54%), Gaps = 75/1397 (5%)
Query: 1269 PFIIFSNRHEIRRIDLHKG--DYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKL 1326
P ++++NR ++R +D G + +++V GL + A+DF S +YW+DV E+ I R +
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
Query: 1327 LDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI 1386
S + V+ GL +P+GLA DW+ +YW +S ++IEV+ LDG+LR L ++
Sbjct: 81 ---NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQEL 137
Query: 1387 EHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEK 1446
+ PRAIALDP G ++WTDW +P+IE A M G+ R + WPNGLT+DY E+
Sbjct: 138 DQPRAIALDPSSGFMYWTDW-GEVPKIERAGMDGSSRFII--INSEIYWPNGLTLDYEEQ 194
Query: 1447 RILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANK 1506
++ W DA+ + I+ + DG+ V++G L HPFA+TL+ +YWTDW T+++ NK
Sbjct: 195 KLYWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNK 252
Query: 1507 WTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLIN-YNRTVSCAC 1565
+TG + + P D+ + RQP A NPC + G CSHLCL++ CAC
Sbjct: 253 YTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID--NGGCSHLCLMSPVKPFYQCAC 310
Query: 1566 PHLMKLHKDNTTCYE-FKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDA 1624
P +KL ++ TC + + LL AR+ ++R + LD P + I+ + DI + +DYD
Sbjct: 311 PTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIV-LQLEDIRHAIAIDYDP 369
Query: 1625 REQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQI 1684
E +YW+D +AI+R+FI+G+G + VV+A + + G+AVDWV+RNL+WT DT +I
Sbjct: 370 VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT--DTGTDRI 427
Query: 1685 NVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDG---DNISMANMDGSNRTLLFSG 1740
V RL+G+ + ++ + LE+P +V+ P+ G +YWTD I A +DGS+R +L +
Sbjct: 428 EVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNT 487
Query: 1741 QKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKL 1799
G P GLA+D+ E K+YW + I N DG+G V+ + ++ ++GD +
Sbjct: 488 SLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL--VEDKIPHIFGFTLLGDYV 545
Query: 1800 WWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQ 1859
+W D + K V++ L M +K + + G+NPC+ NG CS
Sbjct: 546 YWTDWQRRSIERVHKRSAEREVIIDQLPDL-MGLKATNVHRVI---GSNPCAEENGGCSH 601
Query: 1860 LCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVS 1919
LCL + R C C G+ L S + C +FLL+S IR I L+ N+ + A +P++
Sbjct: 602 LCLYRPQGLR-CACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVA-IPLT 659
Query: 1920 GTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNI 1979
G A +DF ++ IYW D+ L TISRA + + E VV G+ EG+AVDW+ N+
Sbjct: 660 GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNL 719
Query: 1980 YWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLD 2039
YW D G + IEV++L+G R V++ + LD PRA+ + P +G+++WTEWG P+I+R+ +D
Sbjct: 720 YWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD 779
Query: 2040 GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMF 2099
G+ER LV ++ NG+++DY +LYW D T+ IE ++ G NREV+ + + F
Sbjct: 780 GSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNM-LGLNREVI-ADDLPHPF 836
Query: 2100 SVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVC 2159
++ ++D+IYW+D + SI+R +K + + ++ + + DI VF+ RQ G N C
Sbjct: 837 GLTQYQDYIYWTD--WSRRSIERANKTSGQNRTIIQGHLD-YVMDILVFHSSRQSGWNEC 893
Query: 2160 AVANGGCQQLCLYRGRGQRACAC-AHGMLAEDGASCREYAGYLLYSERTILKSIHLSDER 2218
A +NG C LCL G C C AH L D +C +LL+S+++ + + + DE+
Sbjct: 894 ASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRM-VIDEQ 952
Query: 2219 NLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITI 2278
+ P ++NV A+ +D ++++ D I++ +DGS+ T+
Sbjct: 953 QSPDIILPIHS---LRNVRAIDYD-------PLDKQLYWIDSRQNMIRKAQEDGSQGFTV 1002
Query: 2279 VENVGSVEGL---AYHRGWDT----LYWTSYTTSTITRHTVDQTRPGAFERETVITMSGD 2331
V + + L Y D +YWT T+ I +D G V+
Sbjct: 1003 VVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVG------VVLKGEQ 1056
Query: 2332 DHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKL 2391
D PRA V++ + M++TN E+ P I RAAL G L + P LA+D R KL
Sbjct: 1057 DRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKL 1116
Query: 2392 YFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGS 2451
+++D+ L +IE + G++R V+ S + P GL V+ ++W D ++ +++ +
Sbjct: 1117 FWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGRE 1176
Query: 2452 NMKLLRVDIPQQPMGIIAVANDTNSCEL--SPCRINNGGCQDLCLLTHQGHVNCSCRGGR 2509
++ I Q + I + N E PC +NGGC +CL+ G CSC
Sbjct: 1177 GRTKVQARIAQ--LSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHL 1234
Query: 2510 I-LQDDLTCRAVNSSCRAQDEFECANGE--CINFSLTCDGVPHCKDKSDEKPSYCNSRRC 2566
+ LQD+L+C +C Q +F C GE CI + CDG C+D SDE N C
Sbjct: 1235 VLLQDELSC-GEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCPVC 1288
Query: 2567 KKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQ 2626
++ QC++G+C+ L CNG +C D SDE C + C + +FRC +G CIG +C+
Sbjct: 1289 SESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCDH 1347
Query: 2627 FVDCEDASDEMNCSATD 2643
VDC D SDE++C T+
Sbjct: 1348 NVDCSDKSDELDCYPTE 1364
Score = 534 bits (1376), Expect = e-151
Identities = 337/1029 (32%), Positives = 524/1029 (50%), Gaps = 86/1029 (8%)
Query: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSV 1244
C ++NGGCSH C ++P +
Sbjct: 286 CGIDNGGCSHLCLMSPVKPFY--------------------------------------- 306
Query: 1245 KCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLV---PGLRNTIA 1301
+C+C G L +G++C+ D ++ + R ++RRI L D++ +V +R+ IA
Sbjct: 307 QCACPTGVKLLENGKTCK--DGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIA 364
Query: 1302 LDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWV 1361
+D+ + +YWTD E + R +D G+ + F V Q +A P+G+AVDW+A N+YW
Sbjct: 365 IDYDPVEGYIYWTDD-EVRAIRRSFID-GSGSQFVVTAQ--IAHPDGIAVDWVARNLYWT 420
Query: 1362 ESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGA 1421
++ D+IEV +L+GT+R L++ D+E PRAI LDP G ++WTDW +P+IE A++ G+
Sbjct: 421 DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW-GEIPKIERAALDGS 479
Query: 1422 GRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHP 1481
R V S GWPNGL +DY E +I W DA++D I DG+G ++ + + H
Sbjct: 480 DR--VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLV--EDKIPHI 535
Query: 1482 FAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPC- 1540
F TL G VYWTDW+ ++ + +K + ++ + L+ + R + NPC
Sbjct: 536 FGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQL-PDLMGLKATNVHR-VIGSNPCA 593
Query: 1541 EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDA 1600
E NGG CSHLCL + + CACP +L D TC + FLL++R+ +IR + L+
Sbjct: 594 EENGG---CSHLCLYR-PQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLET 649
Query: 1601 PYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNA 1660
N I T + + LD+D + R+YW+D+ + I RAF+NG+ +E VV L
Sbjct: 650 NNNNVAIPLT--GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP 707
Query: 1661 HGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWT 1719
G+AVDW+ +NL+W DT +I V++LDG + +V + L+ P L + P G +YWT
Sbjct: 708 EGMAVDWLGKNLYWA--DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWT 765
Query: 1720 D---GDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
+ I A MDGS RT L GL ID+ + +LYW + I N+ G
Sbjct: 766 EWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 825
Query: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
EVI L L D ++W D + +K G +++ VM + V+
Sbjct: 826 EVI---ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVF 882
Query: 1837 DESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYS 1896
S Q G N C+ +NG CS LCL C C A YSL + + C +FLL+S
Sbjct: 883 HSSRQ---SGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFS 939
Query: 1897 VHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1956
I + +D D ++P+ ID+ + +YW+D + I +A+ D +
Sbjct: 940 QKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQG 999
Query: 1957 EDVVTNGIG------RVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKP 2010
VV + + + +++D + IYWT + +VI V RL+G VV+ D+P
Sbjct: 1000 FTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRP 1059
Query: 2011 RAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWC 2069
RA+ V+PEKGY+++T + P+IER+ LDGTER VL +S P +++D + GKL+W
Sbjct: 1060 RAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWA 1119
Query: 2070 DARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHAN-GSIKRGSKDNA 2128
D+ +IE DL +G NR V+ SN + ++VFE+++YW D+ I ++
Sbjct: 1120 DSDLRRIESSDL-SGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGR 1178
Query: 2129 TDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC-AHGML 2187
T V R + +K N + + CA NGGC +CL +G G C+C H +L
Sbjct: 1179 T-KVQARIAQLSDIHAVKELNLQEYR-QHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL 1236
Query: 2188 AEDGASCRE 2196
+D SC E
Sbjct: 1237 LQDELSCGE 1245
Score = 343 bits (881), Expect = 2e-93
Identities = 214/655 (32%), Positives = 353/655 (53%), Gaps = 45/655 (6%)
Query: 199 PVLLIANSQNI-LATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQ-TQL 256
P+LL AN +++ L +G + +TI A+DF +++ + W V + A + T+
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEF 80
Query: 257 KCARMPGLKGFVDEHTINISLS-LHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCV 315
E N+ +S L + +A DWL Y+ D +RI V N +G
Sbjct: 81 NKT----------ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRK 130
Query: 316 TLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLD 375
L EL P+ IALDP+ G +++TD+G++PK+ER MDG +R +++S+I +P+G+TLD
Sbjct: 131 VLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLD 190
Query: 376 LVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQ 435
+ +YWADA L++I + +G RQ +++G L H + LT+FE+ LY T+
Sbjct: 191 YEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSL-PHPFALTLFEDILYWTD------WS 243
Query: 436 KTSVIRVNRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494
S++ N++ ++ + + +H + Q+RQP ++ C D GGCS +CL
Sbjct: 244 THSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNA-TNPCGIDN----GGCSHLCL 298
Query: 495 LANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIP 554
++ C C +G L +GK+CK EL L+ R +R + + + ++
Sbjct: 299 MSPVKPFYQCACPTGVKLLENGKTCKDGATELLLL---ARRTDLRRISLDTPDFTDIVLQ 355
Query: 555 IENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614
+E++ + A+D+ G+IY+ D I R IDG+ + ++ I + +G+AVDW+
Sbjct: 356 LEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVAR 415
Query: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDS 674
NLYWTD G + I V RL RK LI + PRAIV+DP+ G+MYWTDW E PK
Sbjct: 416 NLYWTDTGTDR-IEVTRLN--GTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPK-- 470
Query: 675 RRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRK 734
+ERA +DGS R + V + ++ WPNGL+LD G++YW DA D+IE + +GT R+
Sbjct: 471 ----IERAALDGSDRVVLVNT-SLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRR 525
Query: 735 IVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRM 794
++ E ++ H FG G+Y++WT+++ S+ R+ + + L P + ++
Sbjct: 526 VLVE-DKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQL----PDLMGLKA 580
Query: 795 YDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
+ + +G+N C NGGCS LCL P +CAC L +D TC+ +++
Sbjct: 581 TNV-HRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFL 634
Score = 323 bits (827), Expect = 3e-87
Identities = 242/863 (28%), Positives = 404/863 (46%), Gaps = 108/863 (12%)
Query: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
G CS LC C C G+ L D ++C + LL + +I L
Sbjct: 597 GGCSHLCLYRPQGLRCACPIGFELISDMKTC------IVPEAFLLFSRRADIRRISLETN 650
Query: 218 QVSTITP-TSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINIS 276
+ P T ++ +A+DF + + W + LK + G EH +
Sbjct: 651 NNNVAIPLTGVKEASALDFDVTDNRIYWTDIS-------LKTISRAFMNGSALEHVVEFG 703
Query: 277 LSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGK 336
L + E MA+DWL N Y+ D +RI V +G L+ +L +P+ +ALDPA G
Sbjct: 704 LD--YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGF 761
Query: 337 VFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDY 396
+++T++G PK++R MDG RT LV + + +G+T+D R +YW D + IE +
Sbjct: 762 MYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNM 820
Query: 397 EGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-R 455
G R+ I + H +GLT +++Y+Y T+ + S+ R N+ + ++
Sbjct: 821 LGLNREVIADDL--PHPFGLTQYQDYIYWTD------WSRRSIERANKTSGQNRTIIQGH 872
Query: 456 VDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
+D + ++H RQ A N G CS +CL A C C + +SL +D
Sbjct: 873 LDYVMDILVFHSSRQSGWNECASSN------GHCSHLCL-AVPVGGFVCGCPAHYSLNAD 925
Query: 516 GKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYF 575
++C P FL++ + I M + + + ++PI +L N RA+D+ +Y+
Sbjct: 926 NRTCSAPT--TFLLFSQ--KSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYW 981
Query: 576 ADTTSYLIGRQKIDGTERETILKDGI--HNVE----GVAVDWMGDNLYWTDDGPKKTISV 629
D+ +I + + DG++ T++ + N+E +++D +YWT + I+V
Sbjct: 982 IDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATN-VINV 1040
Query: 630 ARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHR 689
RL+ ++ +++G+ PRA+VV+P G+MY+T+ +E R ++ERA +DG+ R
Sbjct: 1041 TRLD--GRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQE-----RSPKIERAALDGTER 1093
Query: 690 DIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLC 749
++ S + P L+LD G+L+W D+ RIE+ L+G +R IV E + GL
Sbjct: 1094 EVLFFSG-LSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQPVGLT 1151
Query: 750 HHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRV 809
N+L+W + + + +++ V ++ I ++ + Q+ + + C
Sbjct: 1152 VFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYR--QHPCAQ 1209
Query: 810 NNGGCSSLCLAT-PGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQ 868
+NGGCS +CL G+ +C+C VL D ++C PP C P +F C
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC------GEPPTCSPQQFTCFT----- 1258
Query: 869 ERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 928
G+ DC IP W CDG +C + DE N
Sbjct: 1259 ------GEIDC----------------------------IPVAWRCDGFTECEDHSDELN 1284
Query: 929 ATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGR 988
C +QF CASG+CI + C+ D +C D+SDE +C C + QF C NG+
Sbjct: 1285 CP----VCSESQFQCASGQCIDGALRCNGDANCQDKSDEK-NCEV-LCL-IDQFRCANGQ 1337
Query: 989 CININWRCDNDNDCGDNSDEAGC 1011
CI + +CD++ DC D SDE C
Sbjct: 1338 CIGKHKKCDHNVDCSDKSDELDC 1360
Score = 315 bits (808), Expect = 5e-85
Identities = 211/697 (30%), Positives = 352/697 (50%), Gaps = 56/697 (8%)
Query: 158 GTCSQLCTNTDGS--FICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215
G CS LC + + C C G L + ++CK +LL+A ++ L
Sbjct: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD-----GATELLLLARRTDLRRISLD 345
Query: 216 GAQVSTITPT--STRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTI 273
+ I R A+D+ + W +++ R + G + +
Sbjct: 346 TPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWT-------DDEVRAIRRSFIDGSGSQFVV 398
Query: 274 NISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333
++ H + +A+DW+ N Y+ D DRI V NG L+ +L P+ I LDP
Sbjct: 399 TAQIA--HPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPM 456
Query: 334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEV 393
+G +++TD+G+IPK+ER +DG +R LV++ + +P+G+ LD +YW DA D IEV
Sbjct: 457 VGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEV 516
Query: 394 VDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVV 453
++ +G GR+ +++ I H++G T+ +Y+Y T+ Q+ S+ RV++ ++ ++
Sbjct: 517 MNTDGTGRRVLVED-KIPHIFGFTLLGDYVYWTD------WQRRSIERVHKRSAEREVII 569
Query: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLG 513
++ L + R + S+ C + GGCS +CL + C C GF L
Sbjct: 570 DQLPDLMGLKATNVHRV--IGSNPCAEEN----GGCSHLCLY--RPQGLRCACPIGFELI 621
Query: 514 SDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFI 573
SD K+C P E FL++ R IR + + + IP+ + ALDF I
Sbjct: 622 SDMKTCIVP--EAFLLF--SRRADIRRISLETN-NNNVAIPLTGVKEASALDFDVTDNRI 676
Query: 574 YFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Y+ D + I R ++G+ E +++ G+ EG+AVDW+G NLYW D G + I V++L+
Sbjct: 677 YWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNR-IEVSKLD 735
Query: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Q R+ L+ + PRA+ +DP G+MYWT+W PK ++RA MDGS R V
Sbjct: 736 --GQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPK------IDRAAMDGSERTTLV 787
Query: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
+ V NGL++D RLYW D + IE+ + G +R+++ + +L H FGL + +
Sbjct: 788 PN--VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIAD--DLPHPFGLTQYQD 843
Query: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Y++WT++ S+ R + G T+++ + +I ++ + +Q G N+C +NG
Sbjct: 844 YIYWTDWSRRSIERANKTSG---QNRTIIQGHLDYVMDILVFHSSRQS-GWNECASSNGH 899
Query: 814 CSSLCLATP-GSRQCACAEDQVLDADGVTCLANPSYV 849
CS LCLA P G C C L+AD TC A +++
Sbjct: 900 CSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFL 936
Score = 289 bits (740), Expect = 4e-77
Identities = 145/311 (46%), Positives = 205/311 (65%), Gaps = 7/311 (2%)
Query: 3029 PFLIFANRYYLRKLNLDGS--NYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRM 3086
P L++ANR LR ++ N T++ GL +A A+DF + +IYW+DV+ + I+R
Sbjct: 21 PLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEA--IKRT 78
Query: 3087 HLNGS-NVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLR 3145
N + +VQ + +GL +PDGLA DW+G LYW D + IEVS L+G+ R VL L
Sbjct: 79 EFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELD 138
Query: 3146 EPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYW 3205
+PRA+ +D +G++YWTDWG+ I R GMDGSSR +I++++I WPNGLTLDY +++YW
Sbjct: 139 QPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYW 198
Query: 3206 ADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNK 3265
ADA+ ++I ++LDG+NR V+ +PH FALTLFED +YWTDW T SI +K TG
Sbjct: 199 ADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGL 258
Query: 3266 TLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSP-GGGHKCACPTNFYLG 3324
+ S + PMD+H F RQP+ N PC ++NGGCS+LCL+SP ++CACPT L
Sbjct: 259 REIHSDIFSPMDIHAFSQQRQPNATN-PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLL 317
Query: 3325 SDGRTCVSNCT 3335
+G+TC T
Sbjct: 318 ENGKTCKDGAT 328
Score = 280 bits (717), Expect = 2e-74
Identities = 150/345 (43%), Positives = 206/345 (59%), Gaps = 14/345 (4%)
Query: 2992 CSQRCINTHGS--YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNY 3049
CS C+ + Y+C C G +CK E L+ A R LR+++LD ++
Sbjct: 293 CSHLCLMSPVKPFYQCACPTGVKLLENGK-TCKDGATE--LLLLARRTDLRRISLDTPDF 349
Query: 3050 T---LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
T L + + +A+A+D+D E IYWTD + IRR ++GS Q + +++PDG
Sbjct: 350 TDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRA--IRRSFIDGSGSQFVVTAQIAHPDG 407
Query: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
+AVDWV NLYW D G D IEV++LNG R +L+S L EPRA+V+D GY+YWTDWG+
Sbjct: 408 IAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGE 467
Query: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226
I R +DGS R V+V+T + WPNGL LDY +IYW DA+ D IE + DG+ R V+
Sbjct: 468 IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL 527
Query: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQ 3286
+ IPHIF TL DYVYWTDW+ +SI R HK + + ++I L M L + R
Sbjct: 528 VEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREVIIDQLPDLMGLKATNVHRV 586
Query: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
+ ++PC NGGCS+LCL P G +CACP F L SD +TC+
Sbjct: 587 --IGSNPCAEENGGCSHLCLYRP-QGLRCACPIGFELISDMKTCI 628
Score = 278 bits (711), Expect = 9e-74
Identities = 146/354 (41%), Positives = 208/354 (58%), Gaps = 12/354 (3%)
Query: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLD--GSNY 3049
CS C+ +C C G+ K E FL+F+ R +R+++L+ +N
Sbjct: 599 CSHLCLYRPQGLRCACPIGFELIS----DMKTCIVPEAFLLFSRRADIRRISLETNNNNV 654
Query: 3050 TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAV 3109
+ G+ A ALDFD + IYWTD++ + I R +NGS ++ + GL P+G+AV
Sbjct: 655 AIPLTGVKEASALDFDVTDNRIYWTDISLK--TISRAFMNGSALEHVVEFGLDYPEGMAV 712
Query: 3110 DWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSL 3169
DW+G NLYW D G + IEVSKL+G +R VLV L PRAL +D G++YWT+WG
Sbjct: 713 DWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPK 772
Query: 3170 IGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQ 3229
I R MDGS R+ +V + NGLT+DY R+YW D + IE +++ G NR V+ +
Sbjct: 773 IDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI-AD 830
Query: 3230 DIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDV 3289
D+PH F LT ++DY+YWTDW +SI RA+KT+G N+T++ L MD+ VFH+ RQ
Sbjct: 831 DLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGW 890
Query: 3290 PNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKN 3343
+ C +NG CS+LCL P GG C CP ++ L +D RTC + T F K+
Sbjct: 891 --NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
Score = 256 bits (653), Expect = 5e-67
Identities = 157/481 (32%), Positives = 253/481 (52%), Gaps = 27/481 (5%)
Query: 2984 DEC-STTFPCSQRCINTH-GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRK 3041
+EC S+ CS C+ G + C C Y+ D +C A T FL+F+ + + +
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYS-LNADNRTCSAPTT---FLLFSQKSAINR 946
Query: 3042 LNLD---GSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSN-----V 3093
+ +D + L L N A+D+D ++ +YW D ++ +MIR+ +GS V
Sbjct: 947 MVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWID--SRQNMIRKAQEDGSQGFTVVV 1004
Query: 3094 QVLHRTGLS-NPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVV 3152
+ L P L++D +YW + + I V++L+G V++ PRA+VV
Sbjct: 1005 SSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVV 1064
Query: 3153 DVQNGYLYWTDWGDHS-LIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADARED 3211
+ + GY+Y+T+ + S I R +DG+ R V+ + ++ P L LD +++WAD+
Sbjct: 1065 NPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLR 1124
Query: 3212 YIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLIST 3271
IE + L G+NR V+ +I LT+FE+++YW D + + I + T +T + +
Sbjct: 1125 RIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQAR 1184
Query: 3272 LHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC- 3330
+ + D+H L + HPC +NGGCS++CL+ G +C+CP + L D +C
Sbjct: 1185 IAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCG 1244
Query: 3331 -VSNCTASQFVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICT 3387
C+ QF C + CIP W+CD +C DHSDE +CP C QFQC++G C
Sbjct: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-LNCP--VCSESQFQCASGQCI 1301
Query: 3388 NPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERD 3447
+ A C+GD +CQD SDE NC++ +CL QF+C N +CI +C+ +C D DE D
Sbjct: 1302 DGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCAN-GQCIGKHKKCDHNVDCSDKSDELD 1359
Query: 3448 C 3448
C
Sbjct: 1360 C 1360
Score = 192 bits (489), Expect = 5e-48
Identities = 100/240 (41%), Positives = 138/240 (57%), Gaps = 8/240 (3%)
Query: 3949 VTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVV 4008
V ++ +SGL P G+A DW+ +YWTDS + IEV+ + G RK L +D+P AI +
Sbjct: 86 VQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIAL 145
Query: 4009 DPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSV 4068
DP G MYW+DWG PKIE A MDG+ R ++ I WP GL +DY ++LYWADAKL+
Sbjct: 146 DPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNF 205
Query: 4069 IGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTG 4128
I L+GT+ A K L HPF++ +FED +Y + + + +K+ L +
Sbjct: 206 IHKSNLDGTNR--QAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHS 263
Query: 4129 GLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV--CTCPNG-KRLDNG-TC 4182
+ D+ + Q +QP TNPC D C LCL+SP P C CP G K L+NG TC
Sbjct: 264 DIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTC 323
Score = 179 bits (453), Expect = 7e-44
Identities = 121/361 (33%), Positives = 174/361 (48%), Gaps = 32/361 (8%)
Query: 3832 GTCSQLC--NNTKGGHLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPH 3887
G CS LC + K + C+C N TCK +E +L +A ++R + P
Sbjct: 291 GGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATE--LLLLARRTDLRRISLDTPD 348
Query: 3888 SAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDR 3947
+ Q ++ A+D G +YWT+ I R ID
Sbjct: 349 FT-DIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAI----------------RRSFIDG 391
Query: 3948 GVTHLNISG-LKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006
+ ++ + P GIA+DWVA N+YWTD+G D IEV ++ G RK LIS ++EP AI
Sbjct: 392 SGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAI 451
Query: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066
V+DP+ G MYW+DWG PKIE AA+DG+ R LV ++ WP GLA+DY ++YW DAK
Sbjct: 452 VLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKT 511
Query: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126
I + +GT V + K + H F + DY+Y + + ++HK V +
Sbjct: 512 DKIEVMNTDGTGRRVLVEDK--IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREV-I 568
Query: 4127 TGGLSHASDVVLYHQHKQPEVTNPCDRKK--CEWLCLLSPSGPVCTCPNGKRL--DNGTC 4182
L + + H+ +NPC + C LCL P G C CP G L D TC
Sbjct: 569 IDQLPDLMGLKATNVHRVIG-SNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Query: 4183 V 4183
+
Sbjct: 628 I 628
Score = 177 bits (448), Expect = 3e-43
Identities = 123/376 (32%), Positives = 177/376 (47%), Gaps = 37/376 (9%)
Query: 3814 HTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNF--MKTHNTCKAEGSEYQVLY 3871
H V G C + N G CS LC G C+C F + TC +
Sbjct: 584 HRVIGSNPCAEEN-----GGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSR 638
Query: 3872 IADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPP 3931
AD I SL + + A + S A+D V R+YWT+ TIS +
Sbjct: 639 RADIRRI-SLETNNNNVAIPLTGVKEAS----ALDFDVTDNRIYWTDISLKTISRAFMNG 693
Query: 3932 AAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGEN 3991
+A + H+ GL P G+A+DW+ N+YW D+G + IEV+++ G++
Sbjct: 694 SA---------------LEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
Query: 3992 RKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLA 4051
R+ L+ +D P A+ +DP G MYW++WG PKI+ AAMDG+ R TLV N+ GL
Sbjct: 739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV-PNVGRANGLT 797
Query: 4052 VDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNR 4111
+DY RLYW D ++I S + G + V AD L HPF + ++DYIY +
Sbjct: 798 IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD---LPHPFGLTQYQDYIYWTDWSRRS 854
Query: 4112 VFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLLSP-SGPV 4168
+ + +K + G L + D++++H +Q N C C LCL P G V
Sbjct: 855 IERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASSNGHCSHLCLAVPVGGFV 913
Query: 4169 CTCPNGKRL--DNGTC 4182
C CP L DN TC
Sbjct: 914 CGCPAHYSLNADNRTC 929
Score = 134 bits (336), Expect = 3e-30
Identities = 106/408 (25%), Positives = 173/408 (42%), Gaps = 63/408 (15%)
Query: 1183 DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKF 1242
++C+ +NG CSH C P G VC CP L DN TC +
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPT----------------- 933
Query: 1243 SVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRI---DLHKGDYSVLVPGLRNT 1299
F++FS + I R+ + D + + LRN
Sbjct: 934 --------------------------TFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
Query: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVI-----QYGLATPEGLAVDWI 1354
A+D+ LYW D ++ I + + ++G+ F VV+ Q P L++D
Sbjct: 968 RAIDYDPLDKQLYWIDSRQNMIRKAQ--EDGS-QGFTVVVSSVPSQNLEIQPYDLSIDIY 1024
Query: 1355 AGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIE 1414
+ IYW + I V +LDG +L G+ + PRA+ ++P G +++T+ P+IE
Sbjct: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
Query: 1415 AASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRG 1474
A++ G R + S P L +D ++ W D+ I S+ D SG ++
Sbjct: 1085 RAALDGTEREVLFFSGLSK--PIALALDSRLGKLFWADSDLRRIESS--DLSGANRIVLE 1140
Query: 1475 HEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQ-VYHPSRQ 1533
+ P +T++ +YW D + + K + T VQ Q D+ V + Q
Sbjct: 1141 DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
Query: 1534 PMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYE 1580
+PC + NGG CSH+CL+ + T C+CP + L +D +C E
Sbjct: 1201 EYRQHPCAQDNGG---CSHICLVKGDGTTRCSCPMHLVLLQDELSCGE 1245
Score = 124 bits (310), Expect = 3e-27
Identities = 115/413 (27%), Positives = 168/413 (40%), Gaps = 40/413 (9%)
Query: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTV-----LWPNGLS 705
RAI DPL+ +YW D SR+ + +A DGS V S + P LS
Sbjct: 968 RAIDYDPLDKQLYWID-------SRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLS 1020
Query: 706 LDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN-HAFGLCHHGNYLFWTEYRSGS 764
+DI + +YW + I L+G +V +G + A + Y+++T + S
Sbjct: 1021 IDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERS 1080
Query: 765 VYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGS 824
+ G V PI D++ ++ + S L G+
Sbjct: 1081 PKIERAALDGTEREVLFFSGLSKPI--ALALDSRLGKLFWADSDLRRIESSDLS----GA 1134
Query: 825 RQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSD 884
+ + +L G+T N Y Q Q E R + R K L +
Sbjct: 1135 NRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGR--EGRTKVQARIAQLSDIH 1192
Query: 885 EAPAL----CHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED----ESNATCSAR-T 935
L QH C D C + + DG C + +C T
Sbjct: 1193 AVKELNLQEYRQHPCAQDNGGCSHICLVKG----DGTTRCSCPMHLVLLQDELSCGEPPT 1248
Query: 936 CPPNQFSCASGR--CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININ 993
C P QF+C +G CIP++W CD +C D SDE +C P C +QF C +G+CI+
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE-LNC--PVCSE-SQFQCASGQCIDGA 1304
Query: 994 WRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
RC+ D +C D SDE C C QF+C +G+CI +H CD + DC D SDE
Sbjct: 1305 LRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 121 bits (304), Expect = 1e-26
Identities = 55/115 (47%), Positives = 72/115 (62%), Gaps = 4/115 (3%)
Query: 3535 TCEPYQFRCKNNR--CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
TC P QF C C+P W+CD +C D+SDE +C CSES+F CA+G+CI G
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCIDGAL 1305
Query: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
+C+GD +C D SDEK+C C +DQF+C +G CI +CD + DC D SDE C
Sbjct: 1306 RCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 113 bits (283), Expect = 4e-24
Identities = 78/248 (31%), Positives = 122/248 (49%), Gaps = 14/248 (5%)
Query: 3960 PRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSD 4019
P ++ID + +YWT +VI V ++ G + ++ G D P A+VV+P +G MY+++
Sbjct: 1016 PYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTN 1075
Query: 4020 WGNH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD 4078
PKIE AA+DGT RE L + P LA+D +L+WAD+ L I S L+G +
Sbjct: 1076 LQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN 1135
Query: 4079 PIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDV-V 4137
IV DS + P + VFE+++Y + + KI G + ++ SD+
Sbjct: 1136 RIVLEDS--NILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHA 1193
Query: 4138 LYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPV-CTCPNGKRL--DNGTCVPVPSPTPPP 4192
+ + Q +PC D C +CL+ G C+CP L D +C PP
Sbjct: 1194 VKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC-----GEPPT 1248
Query: 4193 DAPRPGTC 4200
+P+ TC
Sbjct: 1249 CSPQQFTC 1256
Score = 108 bits (270), Expect = 1e-22
Identities = 57/123 (46%), Positives = 68/123 (55%), Gaps = 7/123 (5%)
Query: 3566 DEESC-TPRPCSESEFSCANGR--CIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS 3622
DE SC P CS +F+C G CI W+CDG +C D SDE +C P C QFQC S
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC-PVCSESQFQCAS 1297
Query: 3623 GHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDN 3682
G CI RC+ DA+C D SDE+ C C +D+F+C N C KCD DC D
Sbjct: 1298 GQCIDGALRCNGDANCQDKSDEKNCEV---LCLIDQFRCANGQCIGKHKKCDHNVDCSDK 1354
Query: 3683 SDE 3685
SDE
Sbjct: 1355 SDE 1357
Score = 103 bits (256), Expect = 5e-21
Identities = 54/129 (41%), Positives = 70/129 (54%), Gaps = 13/129 (10%)
Query: 3485 EPANCT--QMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542
EP C+ Q TC E C IP W+CDG +C D SDE C C QF+
Sbjct: 1245 EPPTCSPQQFTCFTGEIDC------IPVAWRCDGFTECEDHSDELN--CP--VCSESQFQ 1294
Query: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCAD 3602
C + +C+ G +C+ D +C D SDE++C C +F CANG+CI KCD + DC+D
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSD 1353
Query: 3603 GSDEKDCTP 3611
SDE DC P
Sbjct: 1354 KSDELDCYP 1362
Score = 102 bits (253), Expect = 1e-20
Identities = 56/134 (41%), Positives = 71/134 (52%), Gaps = 14/134 (10%)
Query: 966 DESASCAYPTCFPLTQFTCNNGR--CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCN 1023
DE + PTC P QFTC G CI + WRCD +C D+SDE C CS +QF+C
Sbjct: 1239 DELSCGEPPTCSP-QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP-VCSESQFQCA 1296
Query: 1024 SGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCD 1083
SG+CI C+GD +C D SDE + C D+F+C +G CI +CD
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL---------CLIDQFRCA-NGQCIGKHKKCD 1346
Query: 1084 GDTDCMDSSDEKSC 1097
+ DC D SDE C
Sbjct: 1347 HNVDCSDKSDELDC 1360
Score = 99.8 bits (247), Expect = 6e-20
Identities = 68/179 (37%), Positives = 83/179 (46%), Gaps = 38/179 (21%)
Query: 1007 DEAGCSHSC-----SSTQFKCNSGRCIPEHWTCDGDN-DCGDYSDETHANCTNQATRPPG 1060
D GCSH C +T+ C P H D CG+ P
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSC------PMHLVLLQDELSCGE----------------PP 1247
Query: 1061 GCHTDEFQCRLDGL-CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCI 1119
C +F C + CIP+ WRCDG T+C D SDE +C VC S +F C S +CI
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSES-QFQCA-SGQCI 1301
Query: 1120 SKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
A C+GD +C+D SDE+NCE L C CAN C+ K CD N DC D SDE
Sbjct: 1302 DGALRCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQ--CIGKHKKCDHNVDCSDKSDE 1357
Score = 95.1 bits (235), Expect = 1e-18
Identities = 62/155 (40%), Positives = 76/155 (49%), Gaps = 25/155 (16%)
Query: 1007 DEAGCSH--SCSSTQFKCNSGR--CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGC 1062
DE C +CS QF C +G CIP W CDG +C D+SDE NC C
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCPV--------C 1288
Query: 1063 HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKA 1122
+FQC G CI RC+GD +C D SDEK+CE V + D +F C + +CI K
Sbjct: 1289 SESQFQCA-SGQCIDGALRCNGDANCQDKSDEKNCE-VLCLID---QFRCANG-QCIGKH 1342
Query: 1123 WVCDGDNDCEDNSDEENCESLACRPPSHPCANNTS 1157
CD + DC D SDE L C P P T+
Sbjct: 1343 KKCDHNVDCSDKSDE-----LDCYPTEEPAPQATN 1372
Score = 93.6 bits (231), Expect = 4e-18
Identities = 57/133 (42%), Positives = 75/133 (56%), Gaps = 12/133 (9%)
Query: 3404 DEANC-DIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCS 3461
DE +C + C P QF C T CIP +RC+G C D DE +CP C+ +QFQC+
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
Query: 3462 ITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCG 3521
+ +CI C+ D +C D SDE NC ++ C +D+FRC +G+CI KCD DC
Sbjct: 1297 -SGQCIDGALRCNGDANCQDKSDE-KNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCS 1352
Query: 3522 DGSDE----PKEE 3530
D SDE P EE
Sbjct: 1353 DKSDELDCYPTEE 1365
Score = 87.8 bits (216), Expect = 2e-16
Identities = 40/100 (40%), Positives = 54/100 (54%), Gaps = 5/100 (5%)
Query: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGE 2725
C +W CDG +C D+SDE +CP C + F C SG+CI + C+ + +C+
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPV-----CSESQFQCASGQCIDGALRCNGDANCQDKS 1317
Query: 2726 DETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
DE +C C QF C N +CI K CD + DC D SDE
Sbjct: 1318 DEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 85.9 bits (211), Expect = 8e-16
Identities = 56/141 (39%), Positives = 69/141 (48%), Gaps = 15/141 (10%)
Query: 2725 EDETHCNK--FCSEAQFECQNHR--CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFS 2780
+DE C + CS QF C CI W CDG +C D SDE +C C S F
Sbjct: 1238 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-NCP--VCSESQFQ 1294
Query: 2781 CPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHD 2840
C C+ C+GD +C D +DE C C +F C N QCI KH CDH+
Sbjct: 1295 CASGQ-CIDGALRCNGDANCQDKSDEK---NC--EVLCLIDQFRCANGQCIGKHKKCDHN 1348
Query: 2841 RDCADGSDESPECEYPTCGPS 2861
DC+D SDE +C YPT P+
Sbjct: 1349 VDCSDKSDEL-DC-YPTEEPA 1367
Score = 78.2 bits (191), Expect = 2e-13
Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 16/160 (10%)
Query: 3631 RCDADADCMDGSDEEACGTGVRTCPLDEFQC--NNTLCKPLAWKCDGEDDCGDNSDENPE 3688
RC + DE +CG TC +F C C P+AW+CDG +C D+SDE
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPP-TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL-- 1283
Query: 3689 ECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFL 3748
C VC ++ F+C + + C+ +C+G NC D +DE++CE +F
Sbjct: 1284 NCP--VCSESQ-FQCASGQ-CIDGALRCNGDANCQDKSDEKNCEVLCLID-------QFR 1332
Query: 3749 CRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN 3788
C N +C+ +C+ DC D SDE DC + ATN
Sbjct: 1333 CANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATN 1372
Score = 77.0 bits (188), Expect = 4e-13
Identities = 54/157 (34%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
Query: 2848 DESPECEYPTCGPSEFRCANGR--CLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN 2905
DE E PTC P +F C G C+ W CDG +C D SDE P C+
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVA-WRCDGFTECEDHSDEL-NCPVCSE------ 1290
Query: 2906 ASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKC 2965
SQF C+SG+C+ AL CNG +C D SDE+ C + CL + + C IG
Sbjct: 1291 --SQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQC----IGKHK 1343
Query: 2966 RCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGS 3002
+C D +D +C T + + NT GS
Sbjct: 1344 KCDHNVDCSDK----SDELDCYPTEEPAPQATNTVGS 1376
Score = 64.3 bits (155), Expect = 3e-09
Identities = 44/125 (35%), Positives = 55/125 (44%), Gaps = 23/125 (18%)
Query: 24 PKTCSPKQFAC-RDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT 82
P TCSP+QF C +I CI WRCDG +C D SDE CP C ++ C
Sbjct: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN--CPV-----CSESQFQCASG 1298
Query: 83 ELCVPMSRLCNGVQDCMDGSDEGPHCREL---------QGNC--SRLGCQHH--CVPTLD 129
+ C+ + CNG +C D SDE +C L G C C H+ C D
Sbjct: 1299 Q-CIDGALRCNGDANCQDKSDE-KNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
Query: 130 GPTCY 134
CY
Sbjct: 1357 ELDCY 1361
Score = 61.2 bits (147), Expect = 2e-08
Identities = 43/118 (36%), Positives = 52/118 (44%), Gaps = 12/118 (10%)
Query: 1081 RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC-KDSARCISKAWVCDGDNDCEDNSDEEN 1139
RC + DE SC G C P +F C CI AW CDG +CED+SDE N
Sbjct: 1227 RCSCPMHLVLLQDELSC-GEPPTCSPQ-QFTCFTGEIDCIPVAWRCDGFTECEDHSDELN 1284
Query: 1140 CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGE-----LCDQCSLNNGGC 1192
C C CA+ C+ C+G+ +C D SDE L DQ NG C
Sbjct: 1285 CP--VCSESQFQCASGQ--CIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQC 1338
Score = 45.1 bits (105), Expect = 0.002
Identities = 27/99 (27%), Positives = 46/99 (46%)
Query: 3979 RDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRET 4038
RD+ V G+ T++ G +++ A+ G +YWSD T +
Sbjct: 29 RDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQN 88
Query: 4039 LVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGT 4077
+V + P GLA D+ E+LYW D++ + I L+G+
Sbjct: 89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Score = 42.7 bits (99), Expect = 0.008
Identities = 43/147 (29%), Positives = 61/147 (41%), Gaps = 16/147 (10%)
Query: 3898 ESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGL 3957
E R A+ V+ + G +Y+TN + RS P + R++ L SGL
Sbjct: 1055 EQDRPRAVVVNPEKGYMYFTN-----LQERS--PKIERAALDGTEREV------LFFSGL 1101
Query: 3958 KMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYW 4017
P +A+D G ++W DS IE + + G NR L I +P + V +YW
Sbjct: 1102 SKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTV--FENWLYW 1159
Query: 4018 SDWGNHPKIETAAMDGTLRETLVQDNI 4044
D IE M G T VQ I
Sbjct: 1160 ID-KQQQMIEKIDMTGREGRTKVQARI 1185
Score = 37.7 bits (86), Expect = 0.26
Identities = 17/44 (38%), Positives = 23/44 (52%)
Query: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCA 1228
C+ +NGGCSH C V CSCP+ + L D +C C+
Sbjct: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCS 1250
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 810 bits (2091), Expect = 0.0
Identities = 488/1394 (35%), Positives = 750/1394 (53%), Gaps = 73/1394 (5%)
Query: 1269 PFIIFSNRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKL 1326
P ++F+NR ++R +D K + +++V GL + A+DF S+ A+YWTDV E+ I + L
Sbjct: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
Query: 1327 LDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI 1386
GA + + V+ GL +P+GLA DW+ +YW +S ++IEVA L+GT R L D+
Sbjct: 93 NQTGA--AVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
Query: 1387 EHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEK 1446
+ PRAIALDP G ++WTDW PRIE A M G+ R+ + WPNGLT+D E+
Sbjct: 151 DQPRAIALDPAHGYMYWTDW-GETPRIERAGMDGSTRKII--VDSDIYWPNGLTIDLEEQ 207
Query: 1447 RILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANK 1506
++ W DA+ I+ A DGS +V+ G L+HPFA+TL G +YWTDW+T ++ NK
Sbjct: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNK 265
Query: 1507 WTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT-VSCAC 1565
TG + P D+QV RQP CE + G CSHLCL++ + +CAC
Sbjct: 266 RTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPSEPFYTCAC 323
Query: 1566 PHLMKLHKDNTTCYE-FKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDA 1624
P ++L + TC ++ LL AR+ ++R + LD P + I+ V DI + +DYD
Sbjct: 324 PTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIV-LQVDDIRHAIAIDYDP 382
Query: 1625 REQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQI 1684
E VYW+D +AI+RA+++G+G +T+V+ ++ + G+AVDWV+RNL+WT DT +I
Sbjct: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWT--DTGTDRI 440
Query: 1685 NVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSG 1740
V RL+G+ + +V + L++P + +HP+ G +YWTD G+N I AN+DG R +L +
Sbjct: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
Query: 1741 QKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKL 1799
G P GLA+D E KLYW + I N+DG+ + + +L ++GD +
Sbjct: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL--LEDKLPHIFGFTLLGDFI 558
Query: 1800 WWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQ 1859
+W D + K S V++ L M +K + + + GTNPC+ NG CS
Sbjct: 559 YWTDWQRRSIERVHKVKASRDVIIDQLPDL-MGLKAVNVAKVV---GTNPCADRNGGCSH 614
Query: 1860 LCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVS 1919
LC T TR C C G L S + C +FL+++ I I L+ N+ +D +P++
Sbjct: 615 LCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNN-NDVAIPLT 672
Query: 1920 GTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNI 1979
G A +DF N+ IYW D+ L TISRA + + E VV G+ EG+AVDW+ N+
Sbjct: 673 GVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNL 732
Query: 1980 YWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLD 2039
YW D G + IEVARL+G FR V++ + LD PR++ + P KGY++WTEWG PRI R+ +D
Sbjct: 733 YWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMD 792
Query: 2040 GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMF 2099
GT + LV+ + N +++DY D +LYW D T+ IE ++ G+ R VV++ + F
Sbjct: 793 GTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNM-LGQER-VVIADDLPHPF 849
Query: 2100 SVSVFEDFIYWSD-RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNV 2158
++ + D+IYW+D H SI+R K + + ++ + + DI VF+ RQ G N
Sbjct: 850 GLTQYSDYIYWTDWNLH---SIERADKTSGRNRTLIQGHLDF-VMDILVFHSSRQDGLND 905
Query: 2159 CAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDER 2218
C NG C QLCL G R +H L +C +LL+S+++ + + + D++
Sbjct: 906 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM-IPDDQ 964
Query: 2219 NLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRR--I 2276
+ + P ++NV A+ +D I++ D NI++ DDG++ +
Sbjct: 965 HSPDLILPLHG---LRNVKAIDYD-------PLDKFIYWVDGR-QNIKRAKDDGTQPFVL 1013
Query: 2277 TIVENVGSVEGLAYHRGWD----TLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGD- 2331
T + + + + D TL+WT T+TI H + G + + GD
Sbjct: 1014 TSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG-------VVLRGDR 1066
Query: 2332 DHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKL 2391
D PRA V++ + +++TN ++ I RAAL G L + P L +D+ KL
Sbjct: 1067 DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKL 1126
Query: 2392 YFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGS 2451
++ DA L +IE C+ G++R + + V P GL + G+H++W D ++ ++R K G
Sbjct: 1127 FWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
Query: 2452 NMKLLRVDIPQQPMGIIAVAN-DTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRI 2510
++ + GI AV PC +NGGC +C+ G CSC +
Sbjct: 1187 KRTRIQGRVAHL-TGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLV 1245
Query: 2511 LQDDLTCRAVNSSCRAQDEFECANGE--CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKK 2568
L +L +C + D+F CA GE CI + CDG P C D+SDE+ C
Sbjct: 1246 LLQNLLTCGEPPTC-SPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE----GCPVCSA 1300
Query: 2569 TFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFV 2628
C+ G+CV L C+G DC D SDE C+ C +FRC G C+ +C+ F
Sbjct: 1301 AQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFP 1359
Query: 2629 DCEDASDEMNCSAT 2642
DC D SDE+ C T
Sbjct: 1360 DCIDGSDELMCEIT 1373
Score = 488 bits (1257), Expect = e-137
Identities = 326/1035 (31%), Positives = 506/1035 (48%), Gaps = 99/1035 (9%)
Query: 1184 QCSLNNGGCSHNCSVAPGEGI-VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKF 1242
+C +NGGCSH C ++P E C+CP G++L + TC+ +
Sbjct: 298 RCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGA----------------- 340
Query: 1243 SVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYS---VLVPGLRNT 1299
+ ++ + R ++RRI L D++ + V +R+
Sbjct: 341 -------------------------EEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHA 375
Query: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
IA+D+ + +YWTD I R L +GA T ++ + P+G+AVDW+A N+Y
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQT----LVNTEINDPDGIAVDWVARNLY 431
Query: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
W ++ D+IEV +L+GT R L++ D++ PRAIAL P G+++WTDW + P+IE A++
Sbjct: 432 WTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN-PKIECANLD 490
Query: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
G RR + S GWPNGL +D E ++ W DA++D I DG+ +L + L
Sbjct: 491 GQERRVL--VNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLL--EDKLP 546
Query: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNP 1539
H F TL G +YWTDW+ ++ + +K ++ + L+ + ++ + NP
Sbjct: 547 HIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQL-PDLMGLKAVNVAK-VVGTNP 604
Query: 1540 C-EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDL 1598
C + NGG CSHLC + T C CP ++L D TC + FL++ + I + L
Sbjct: 605 CADRNGG---CSHLCFFTPHAT-RCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
Query: 1599 DAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLP 1658
+ N ++ + + + LD+D +YW+DV + I RAF+NG+ VE VV L
Sbjct: 661 ET--NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLD 718
Query: 1659 NAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLY 1717
G+AVDW+ +NL+W DT +I VARLDG F+ +V + L+ P L + P +G +Y
Sbjct: 719 YPEGMAVDWMGKNLYWA--DTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
Query: 1718 WTD---GDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGS 1774
WT+ I A MDG+N L L ID+ + +LYW + I N+ G
Sbjct: 777 WTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQ 836
Query: 1775 GLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMK 1834
VI L L D ++W D + K G +++ VM +
Sbjct: 837 ERVVI---ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDIL 893
Query: 1835 VYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLL 1894
V+ S Q G N C NNG C QLCL R C C + Y+L + C +FLL
Sbjct: 894 VFHSSRQ---DGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLL 949
Query: 1895 YSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQT 1954
+S I + D D ++P+ G ID+ + IYWVD G I RAK D T
Sbjct: 950 FSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGT 1008
Query: 1955 WREDVVT------NGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLD 2008
+ V+T N + +++D + ++WT + + I V RL+G VV+ D
Sbjct: 1009 -QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRD 1067
Query: 2009 KPRAITVHPEKGYLFWTEW-GQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLY 2067
KPRAI V+ E+GYL++T + +IER+ LDGTER VL + P + VD GKL+
Sbjct: 1068 KPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLF 1127
Query: 2068 WCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHAN-GSIKRGSKD 2126
W DA +IE DL +G NR + +N + +++ +YW DR +++ + D
Sbjct: 1128 WVDADLKRIESCDL-SGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
Query: 2127 NAT---DSVPLRTGI-GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC 2182
T V TGI V+ ++ F+ + CA NGGC +C+ +G G C+C
Sbjct: 1187 KRTRIQGRVAHLTGIHAVEEVSLEEFS------AHPCARDNGGCSHICIAKGDGTPRCSC 1240
Query: 2183 -AHGMLAEDGASCRE 2196
H +L ++ +C E
Sbjct: 1241 PVHLVLLQNLLTCGE 1255
Score = 346 bits (887), Expect = 3e-94
Identities = 212/658 (32%), Positives = 349/658 (53%), Gaps = 40/658 (6%)
Query: 194 PVDRPPVLLIANSQNILATYLSGAQV-STITPTSTRQTTAMDFSYANETVCWVHVGDSAA 252
P P+LL AN +++ G ++ STI + A+DF ++ V W V + A
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA- 86
Query: 253 QTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
+K + V I+ L + +A DW+ Y+ D +RI V N NG
Sbjct: 87 ---IKQTYLNQTGAAVQNVVIS---GLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
Query: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
+ L +L P+ IALDPA G +++TD+G+ P++ER MDG R +VDS I +P+G+
Sbjct: 141 SRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGL 200
Query: 373 TLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNAN 432
T+DL + +YWADA L +I + +G RQ +++G L H + LT+ + LY T+
Sbjct: 201 TIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSL-THPFALTLSGDTLYWTD----- 254
Query: 433 AQQKTSVIRVN-RFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Q S+ N R ++++ + + + Q RQP + CE D GGCS
Sbjct: 255 -WQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDN----GGCSH 308
Query: 492 ICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEH 551
+CLL+ S TC C +G L +G++CK E+ L+ R +R + + +
Sbjct: 309 LCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDI 365
Query: 552 MIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDW 611
++ ++++ + A+D+ G++Y+ D I R +DG+ +T++ I++ +G+AVDW
Sbjct: 366 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDW 425
Query: 612 MGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDP 671
+ NLYWTD G + I V RL +RK L+ + PRAI + P+ G MYWTDW E+P
Sbjct: 426 VARNLYWTDTGTDR-IEVTRLN--GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENP 482
Query: 672 KDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGT 731
K +E A +DG R + V + ++ WPNGL+LD+ G+LYW DA D+IE I ++GT
Sbjct: 483 K------IECANLDGQERRVLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGT 535
Query: 732 DRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFE 791
R+ + E +L H FG G++++WT+++ S+ R+ + + ++ + P +
Sbjct: 536 KRRTLLE-DKLPHIFGFTLLGDFIYWTDWQRRSIERVHK----VKASRDVIIDQLPDLMG 590
Query: 792 IRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
++ + + VGTN C NGGCS LC TP + +C C L +D TC+ +++
Sbjct: 591 LKAVNV-AKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFL 647
Score = 325 bits (833), Expect = 6e-88
Identities = 245/823 (29%), Positives = 387/823 (47%), Gaps = 78/823 (9%)
Query: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNIL--ATYLS 215
G CS LC T + CGC G L D ++C P L+ S+ + + +
Sbjct: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-------PEAFLVFTSRAAIHRISLET 662
Query: 216 GAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
I T ++ +A+DF +N + W V LK + G EH +
Sbjct: 663 NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVS-------LKTISRAFMNGSSVEHVVEF 715
Query: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
L + E MA+DW+ N Y+ D +RI V +G L+ +L NP+ +ALDP G
Sbjct: 716 GLD--YPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKG 773
Query: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
+++T++G P++ R MDG N LVD K+ + +T+D + +YW D + IE +
Sbjct: 774 YIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSN 832
Query: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYAT--NSDNANAQQKTSVIRVNRFNSTEYQVV 453
G+ R I + H +GLT + +Y+Y T N + KTS +
Sbjct: 833 MLGQERVVIADD--LPHPFGLTQYSDYIYWTDWNLHSIERADKTS-------GRNRTLIQ 883
Query: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL-LANSHKARTCRCRSGFSL 512
+D + ++H RQ + ND G C +CL + H+ C C S ++L
Sbjct: 884 GHLDFVMDILVFHSSRQDGL------NDCMHNNGQCGQLCLAIPGGHR---CGCASHYTL 934
Query: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
++C P FL++ + + I R + PD ++P+ L N +A+D+ F
Sbjct: 935 DPSSRNCSPP--TTFLLFSQ-KSAISRMIPDDQHSPD-LILPLHGLRNVKAIDYDPLDKF 990
Query: 573 IYFADTTSYLIGRQKIDGTER--ETILKDGIH---NVEGVAVDWMGDNLYWTDDGPKKTI 627
IY+ D I R K DGT+ T L G + +++D L+WT + TI
Sbjct: 991 IYWVDGRQN-IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA-TNTI 1048
Query: 628 SVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGS 687
+V RL + + ++ G PRAIVV+ G++Y+T+ ++ R ++ERA +DG+
Sbjct: 1049 NVHRL--SGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQD-----RAAKIERAALDGT 1101
Query: 688 HRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFG 747
R++ T+ ++ P L +D G+L+WVDA RIE+ L+G +R + E + G
Sbjct: 1102 EREVLFTT-GLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR-LTLEDANIVQPLG 1159
Query: 748 LCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKC 807
L G +L+W + + + R+E+ G + + I + + ++ + C
Sbjct: 1160 LTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVE--EVSLEEFSAHPC 1217
Query: 808 RVNNGGCSSLCLAT-PGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSR- 865
+NGGCS +C+A G+ +C+C VL + +TC PP C P +FACA
Sbjct: 1218 ARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC------GEPPTCSPDQFACATGEI 1271
Query: 866 -CIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSE 924
CI W+CDG +C D SDE C + +F C +C+ R CDG+ DC +
Sbjct: 1272 DCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
Query: 925 DESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 967
DE A C A C PNQF CASG+C+ I CD DC D SDE
Sbjct: 1328 DE--ADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 318 bits (815), Expect = 8e-86
Identities = 215/689 (31%), Positives = 350/689 (50%), Gaps = 55/689 (7%)
Query: 158 GTCSQLC--TNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215
G CS LC + ++ + C C G LQ + R+CKA E VLL+A ++ L
Sbjct: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAE-----EVLLLARRTDLRRISLD 358
Query: 216 GAQVSTIT--PTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTI 273
+ I R A+D+ V W +++ R L G + +
Sbjct: 359 TPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW-------TDDEVRAIRRAYLDGSGAQTLV 411
Query: 274 NISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333
N ++ + +A+DW+ N Y+ D DRI V NG + L+ +L P+ IAL P
Sbjct: 412 N--TEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPV 469
Query: 334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEV 393
MG +++TD+G+ PK+E ++DGQ R LV++ + +P+G+ LDL +YW DA D IEV
Sbjct: 470 MGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEV 529
Query: 394 VDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVV 453
++ +G R+T+++ L H++G T+ +++Y T+ Q+ S+ RV++ ++ ++
Sbjct: 530 INVDGTKRRTLLEDKL-PHIFGFTLLGDFIYWTD------WQRRSIERVHKVKASRDVII 582
Query: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLG 513
++ L + + V ++ C + + GGCS +C + A C C G L
Sbjct: 583 DQLPDLMGLKAVNVAKV--VGTNPCAD----RNGGCSHLCFF--TPHATRCGCPIGLELL 634
Query: 514 SDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFI 573
SD K+C P E FLV+ R I R + + D IP+ + ALDF I
Sbjct: 635 SDMKTCIVP--EAFLVF-TSRAAIHR-ISLETNNNDV-AIPLTGVKEASALDFDVSNNHI 689
Query: 574 YFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Y+ D + I R ++G+ E +++ G+ EG+AVDWMG NLYW D G + I VARL+
Sbjct: 690 YWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNR-IEVARLD 748
Query: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Q R+ L+ + +PR++ +DP G++YWT+W P R+ RA+MDG++ V
Sbjct: 749 --GQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP------RIVRAFMDGTNCMTLV 800
Query: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
V N L++D RLYW D + IE+ + G +R ++ + +L H FGL + +
Sbjct: 801 DK--VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD--DLPHPFGLTQYSD 856
Query: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Y++WT++ S+ R ++ G TL++ + +I ++ + +Q G N C NNG
Sbjct: 857 YIYWTDWNLHSIERADKTSG---RNRTLIQGHLDFVMDILVFHSSRQD-GLNDCMHNNGQ 912
Query: 814 CSSLCLATPGSRQCACAEDQVLDADGVTC 842
C LCLA PG +C CA LD C
Sbjct: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRNC 941
Score = 284 bits (727), Expect = 1e-75
Identities = 143/313 (45%), Positives = 197/313 (62%), Gaps = 4/313 (1%)
Query: 3021 CKAVTDEEPFLIFANRYYLRKLNLDGSNY--TLLKQGLNNAVALDFDYREQMIYWTDVTT 3078
C A P L+FANR +R ++ G T++ GL +A A+DF + + +YWTDV+
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 3079 QGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTV 3138
+ ++ G+ VQ + +GL +PDGLA DWVG LYW D + IEV+ LNG R V
Sbjct: 85 EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 144
Query: 3139 LVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 3198
L L +PRA+ +D +GY+YWTDWG+ I R GMDGS+R +IVD+ I WPNGLT+D
Sbjct: 145 LFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDL 204
Query: 3199 VTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH 3258
+++YWADA+ +I A+LDGS R V+ + H FALTL D +YWTDW+T+SI+ +
Sbjct: 205 EEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACN 264
Query: 3259 KTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGG-HKCAC 3317
K TG + ++S L+ PMD+ V RQP C+ +NGGCS+LCLLSP + CAC
Sbjct: 265 KRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDNGGCSHLCLLSPSEPFYTCAC 323
Query: 3318 PTNFYLGSDGRTC 3330
PT L +GRTC
Sbjct: 324 PTGVQLQDNGRTC 336
Score = 266 bits (679), Expect = 5e-70
Identities = 139/345 (40%), Positives = 199/345 (57%), Gaps = 14/345 (4%)
Query: 2992 CSQRCINTHGS--YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNY 3049
CS C+ + Y C C G + +CKA +E L+ A R LR+++LD ++
Sbjct: 306 CSHLCLLSPSEPFYTCACPTGVQLQDNG-RTCKAGAEE--VLLLARRTDLRRISLDTPDF 362
Query: 3050 T---LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
T L + +A+A+D+D E +YWTD + IRR +L+GS Q L T +++PDG
Sbjct: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRA--IRRAYLDGSGAQTLVNTEINDPDG 420
Query: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
+AVDWV NLYW D G D IEV++LNG R +LVS L EPRA+ + G +YWTDWG+
Sbjct: 421 IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE 480
Query: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226
+ I +DG R V+V+ + WPNGL LD ++YW DA+ D IE ++DG+ R +
Sbjct: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
Query: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQ 3286
L +PHIF TL D++YWTDW+ +SI R HK ++ ++I L M L + +
Sbjct: 541 LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVK-ASRDVIIDQLPDLMGLKAVNVAKV 599
Query: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
V +PC NGGCS+LC +P +C CP L SD +TC+
Sbjct: 600 --VGTNPCADRNGGCSHLCFFTP-HATRCGCPIGLELLSDMKTCI 641
Score = 263 bits (672), Expect = 3e-69
Identities = 147/363 (40%), Positives = 210/363 (57%), Gaps = 20/363 (5%)
Query: 2977 GRTCADVDECSTTFPCSQRCINTHGSYKCLCV-EGYAPRGGDPHSCKAVTD------EEP 3029
G +V + T PC+ R +G LC +A R G P + ++D E
Sbjct: 590 GLKAVNVAKVVGTNPCADR----NGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEA 645
Query: 3030 FLIFANRYYLRKLNLDGSN--YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMH 3087
FL+F +R + +++L+ +N + G+ A ALDFD IYWTDV+ + I R
Sbjct: 646 FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLK--TISRAF 703
Query: 3088 LNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREP 3147
+NGS+V+ + GL P+G+AVDW+G NLYW D G + IEV++L+G +R VLV L P
Sbjct: 704 MNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNP 763
Query: 3148 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWAD 3207
R+L +D GY+YWT+WG I R MDG++ +VD K+ N LT+DY +R+YW D
Sbjct: 764 RSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTD 822
Query: 3208 AREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTL 3267
+ IE +++ G R VV++ D+PH F LT + DY+YWTDW SI RA KT+G N+TL
Sbjct: 823 LDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTL 881
Query: 3268 LISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDG 3327
+ L MD+ VFH+ RQ + + C NNG C LCL P GGH+C C +++ L
Sbjct: 882 IQGHLDFVMDILVFHSSRQDGL--NDCMHNNGQCGQLCLAIP-GGHRCGCASHYTLDPSS 938
Query: 3328 RTC 3330
R C
Sbjct: 939 RNC 941
Score = 257 bits (656), Expect = 2e-67
Identities = 159/480 (33%), Positives = 243/480 (50%), Gaps = 30/480 (6%)
Query: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN--- 3048
C Q C+ G ++C C Y DP S + + FL+F+ + + ++ D +
Sbjct: 913 CGQLCLAIPGGHRCGCASHYTL---DPSS-RNCSPPTTFLLFSQKSAISRMIPDDQHSPD 968
Query: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLS---NPD 3105
L GL N A+D+D ++ IYW D I+R +G+ VL T LS NPD
Sbjct: 969 LILPLHGLRNVKAIDYDPLDKFIYWVDGRQN---IKRAKDDGTQPFVL--TSLSQGQNPD 1023
Query: 3106 ----GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYW 3161
L++D L+W + +TI V +L+G V++ +PRA+VV+ + GYLY+
Sbjct: 1024 RQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYF 1083
Query: 3162 TDWGDHSL-IGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDG 3220
T+ D + I R +DG+ R V+ T + P L +D +++W DA IE L G
Sbjct: 1084 TNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSG 1143
Query: 3221 SNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHV 3280
+NR + +I LT+ ++YW D + + I R KTTG +T + + +H
Sbjct: 1144 ANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHA 1203
Query: 3281 FHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC--VSNCTASQ 3338
+ + HPC +NGGCS++C+ G +C+CP + L + TC C+ Q
Sbjct: 1204 VEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQ 1263
Query: 3339 FVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGD 3396
F C + CIP W+CD +C D SDE CP C QF C+ G C + CDG+
Sbjct: 1264 FACATGEIDCIPGAWRCDGFPECDDQSDE-EGCP--VCSAAQFPCARGQCVDLRLRCDGE 1320
Query: 3397 NDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPN 3456
DCQD SDEA+CD +CLP+QF+C + +C+ +C+ +C DG DE C E+T P+
Sbjct: 1321 ADCQDRSDEADCDA-ICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMC-EITKPPS 1377
Score = 185 bits (470), Expect = 8e-46
Identities = 115/329 (34%), Positives = 158/329 (48%), Gaps = 23/329 (6%)
Query: 3860 CKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNW 3919
C A + +L A+ ++R + G G E A+D G VYWT+
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAA--AVDFQFSKGAVYWTDV 82
Query: 3920 HTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGR 3979
I L Q V ++ ISGL P G+A DWV +YWTDS
Sbjct: 83 SEEAIKQTYL-------------NQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSET 129
Query: 3980 DVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETL 4039
+ IEVA + G +RK L +D+P AI +DP G MYW+DWG P+IE A MDG+ R+ +
Sbjct: 130 NRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKII 189
Query: 4040 VQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFE 4099
V +I WP GL +D ++LYWADAKLS I L+G+ + L+HPF++ +
Sbjct: 190 VDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSG 247
Query: 4100 DYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCE 4157
D +Y + + +K + L D+ + Q +QP C D C
Sbjct: 248 DTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCS 307
Query: 4158 WLCLLSPSGP--VCTCPNGKRL-DNG-TC 4182
LCLLSPS P C CP G +L DNG TC
Sbjct: 308 HLCLLSPSEPFYTCACPTGVQLQDNGRTC 336
Score = 181 bits (459), Expect = 1e-44
Identities = 131/381 (34%), Positives = 180/381 (47%), Gaps = 44/381 (11%)
Query: 3813 FHTVPGQPGCQDINECLRFGTCSQLC--NNTKGGHLCSCARNFMKTHN--TCKAEGSEYQ 3868
FHT C++ N G CS LC + ++ + C+C N TCKA E
Sbjct: 295 FHT-----RCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEE-- 342
Query: 3869 VLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRS 3928
VL +A ++R + P + Q D+ A+D G VYWT+ I
Sbjct: 343 VLLLARRTDLRRISLDTPDFT-DIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAY 401
Query: 3929 LPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMK 3988
L + T N T +N P GIA+DWVA N+YWTD+G D IEV ++
Sbjct: 402 LDGSGAQTLVN----------TEIND-----PDGIAVDWVARNLYWTDTGTDRIEVTRLN 446
Query: 3989 GENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPT 4048
G +RK L+S +DEP AI + P+ G MYW+DWG +PKIE A +DG R LV ++ WP
Sbjct: 447 GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPN 506
Query: 4049 GLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYI 4108
GLA+D +LYW DAK I I ++GT + K L H F + D+IY +
Sbjct: 507 GLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK--LPHIFGFTLLGDFIYWTDWQ 564
Query: 4109 NNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEV--TNPC-DRK-KCEWLCLLSP 4164
+ ++HK S V + D++ +V TNPC DR C LC +P
Sbjct: 565 RRSIERVHKVKASRDVI----IDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTP 620
Query: 4165 SGPVCTCPNGKRL--DNGTCV 4183
C CP G L D TC+
Sbjct: 621 HATRCGCPIGLELLSDMKTCI 641
Score = 160 bits (405), Expect = 3e-38
Identities = 107/376 (28%), Positives = 171/376 (45%), Gaps = 52/376 (13%)
Query: 3816 VPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSC--ARNFMKTHNTC---------KAEG 3864
V G C D N G CS LC T C C + TC +
Sbjct: 599 VVGTNPCADRN-----GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRA 653
Query: 3865 SEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTI 3924
+ +++ ++N++ G ++ A+D V +YWT+ TI
Sbjct: 654 AIHRISLETNNNDVAIPLTGVKEAS--------------ALDFDVSNNHIYWTDVSLKTI 699
Query: 3925 SYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEV 3984
S + ++ V H+ GL P G+A+DW+ N+YW D+G + IEV
Sbjct: 700 SRAFMNGSS---------------VEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEV 744
Query: 3985 AQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNI 4044
A++ G+ R+ L+ +D P ++ +DP +G +YW++WG P+I A MDGT TLV D +
Sbjct: 745 ARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKV 803
Query: 4045 QWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYG 4104
L +DY ++RLYW D ++I S + G + +V AD L HPF + + DYIY
Sbjct: 804 GRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADD---LPHPFGLTQYSDYIYW 860
Query: 4105 VTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLL 4162
+ + + + K + G L D++++H +Q + N C + +C LCL
Sbjct: 861 TDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLA 919
Query: 4163 SPSGPVCTCPNGKRLD 4178
P G C C + LD
Sbjct: 920 IPGGHRCGCASHYTLD 935
Score = 125 bits (315), Expect = 7e-28
Identities = 55/115 (47%), Positives = 72/115 (62%), Gaps = 4/115 (3%)
Query: 3535 TCEPYQFRCKNNR--CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
TC P QF C C+PG W+CD +C D SDEE C CS ++F CA G+C+ R
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDLRL 1315
Query: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
+CDG+ DC D SDE DC C +QF+C SG C+ ++ +CD+ DC+DGSDE C
Sbjct: 1316 RCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 115 bits (289), Expect = 8e-25
Identities = 150/645 (23%), Positives = 235/645 (36%), Gaps = 134/645 (20%)
Query: 3825 INECLRF-GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFP 3883
+N+C+ G C QLC GGH C CA ++ ++ +L+ + + I + P
Sbjct: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLF-SQKSAISRMIP 961
Query: 3884 GHPHSA-YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHR 3942
HS G +V+ A+D +YW + + TS
Sbjct: 962 DDQHSPDLILPLHGLRNVK--AIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
Query: 3943 RQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE 4002
+ DR P ++ID + ++WT + I V ++ GE ++ G D+
Sbjct: 1020 QNPDR-----------QPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDK 1068
Query: 4003 PHAIVVDPLRGTMYWSDWGNH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYW 4061
P AIVV+ RG +Y+++ + KIE AA+DGT RE L + P L VD +L+W
Sbjct: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
Query: 4062 ADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHS 4121
DA L I S L+G + + D+ + P + + ++Y + + ++ K
Sbjct: 1129 VDADLKRIESCDLSGANRLTLEDA--NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
Query: 4122 PLVNLTGGLSHASDVVLYHQHKQPEVT-NPC--DRKKCEWLCLLSPSG-PVCTCPNGKRL 4177
+ G ++H + + + E + +PC D C +C+ G P C+CP L
Sbjct: 1187 KRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVL 1246
Query: 4178 DNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCW 4237
PT PD T + C G W
Sbjct: 1247 LQNLLTCGEPPTCSPDQFACATGEIDCIPG----------------------------AW 1278
Query: 4238 EHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPG 4297
RC GF P+C Q ++ C V Q C
Sbjct: 1279 -------------------RC-DGF--PECDDQ------SDEEGCPVCSAAQFPCA---- 1306
Query: 4298 FLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQ 4357
R Q C+ CQ D S + C A C N+ RC G CV+ KQ
Sbjct: 1307 ----RGQCVDLRLRCDGEADCQ---DRSDEADCDAI-----CLPNQ-FRCASGQCVLIKQ 1353
Query: 4358 SGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQ 4417
D +C DG + ++M E PP S
Sbjct: 1354 QCDSFPDCIDG---------------------SDELMCEITKPP------------SDDS 1380
Query: 4418 PGHIASILIPLLLLLLLVLVAGVVFWYKR----RVQGAKG-FQHQ 4457
P H ++I + ++L L ++ GV F +R R GA G F H+
Sbjct: 1381 PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHE 1425
Score = 115 bits (288), Expect = 1e-24
Identities = 113/427 (26%), Positives = 176/427 (41%), Gaps = 48/427 (11%)
Query: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT----SKTVLWPNGLSL 706
+AI DPL+ ++YW D ++ ++RA DG+ + + P+ LS+
Sbjct: 980 KAIDYDPLDKFIYWVDGRQN--------IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSI 1031
Query: 707 DIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGP-ELNHAFGLCHHGNYLFWTEYRSGSV 765
DI + L+W + I L+G +V G + A + YL++T + +
Sbjct: 1032 DIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAA 1091
Query: 766 YRLERGVGGAPPTVTLLRSE--RPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 823
++ER L + RP + + V + R+ + S G
Sbjct: 1092 -KIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-------G 1143
Query: 824 SRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNS 883
+ + + ++ G+T L Y Q Q E + +R + G L
Sbjct: 1144 ANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG--DKRTRIQGRVAHLTGI 1201
Query: 884 DEAPALCHQ----HTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED----ESNATCSAR- 934
+ + H C D C ++ CI DG C ++ TC
Sbjct: 1202 HAVEEVSLEEFSAHPCARDNGGC-SHICIAKG---DGTPRCSCPVHLVLLQNLLTCGEPP 1257
Query: 935 TCPPNQFSCASGR--CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCINI 992
TC P+QF+CA+G CIP +W CD +C D+SDE P C QF C G+C+++
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC---PVC-SAAQFPCARGQCVDL 1313
Query: 993 NWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCT 1052
RCD + DC D SDEA C C QF+C SG+C+ CD DC D SDE
Sbjct: 1314 RLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC--- 1370
Query: 1053 NQATRPP 1059
+ T+PP
Sbjct: 1371 -EITKPP 1376
Score = 100 bits (250), Expect = 3e-20
Identities = 69/181 (38%), Positives = 89/181 (49%), Gaps = 26/181 (14%)
Query: 3568 ESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADG------SDEKDC--TPRCDMDQFQ 3619
E + PC+ C++ CIA K DG C+ + C P C DQF
Sbjct: 1210 EEFSAHPCARDNGGCSH-ICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFA 1265
Query: 3620 CKSGH--CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGED 3677
C +G CIP WRCD +C D SDEE C C +F C C L +CDGE
Sbjct: 1266 CATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRLRCDGEA 1321
Query: 3678 DCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE---PP 3734
DC D SDE +C +C PN+ FRC + + C+ I +QCD +C DG+DE CE PP
Sbjct: 1322 DCQDRSDE--ADCDA-ICLPNQ-FRCASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPP 1376
Query: 3735 T 3735
+
Sbjct: 1377 S 1377
Score = 97.4 bits (241), Expect = 3e-19
Identities = 68/178 (38%), Positives = 86/178 (48%), Gaps = 20/178 (11%)
Query: 3404 DEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT 3463
D C H+C+ K T RC + Q+ GE TC+P+QF C+
Sbjct: 1220 DNGGCS-HICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPP------TCSPDQFACATG 1269
Query: 3464 K-RCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGD 3522
+ CIP W CD +C D SDE C C +F C G+C+ R +CDGE DC D
Sbjct: 1270 EIDCIPGAWRCDGFPECDDQSDEEG-CP--VCSAAQFPCA-RGQCVDLRLRCDGEADCQD 1325
Query: 3523 GSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSES 3578
SDE +CD C P QFRC + +CV + QCD DC D SDE C T P +S
Sbjct: 1326 RSDEA--DCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS 1380
Score = 92.0 bits (227), Expect = 1e-17
Identities = 57/150 (38%), Positives = 72/150 (48%), Gaps = 20/150 (13%)
Query: 1014 SCSSTQFKCNSGR--CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRL 1071
+CS QF C +G CIP W CDG +C D SDE C +F C
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----------CSAAQFPCAR 1307
Query: 1072 DGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDC 1131
G C+ LR RCDG+ DC D SDE C+ +C P+ +F C S +C+ CD DC
Sbjct: 1308 -GQCVDLRLRCDGEADCQDRSDEADCDA---ICLPN-QFRCA-SGQCVLIKQQCDSFPDC 1361
Query: 1132 EDNSDEENCESLACRPPSHPCANNTSVCLP 1161
D SDE CE +PPS ++S P
Sbjct: 1362 IDGSDELMCE--ITKPPSDDSPAHSSAIGP 1389
Score = 90.9 bits (224), Expect = 3e-17
Identities = 63/203 (31%), Positives = 90/203 (44%), Gaps = 28/203 (13%)
Query: 1007 DEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDE 1066
D GCSH C + C CG+ P C D+
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE----------------PPTCSPDQ 1263
Query: 1067 FQCRLDGL-CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVC 1125
F C + CIP WRCDG +C D SDE+ C VC + +F C +C+ C
Sbjct: 1264 FACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCS-AAQFPCA-RGQCVDLRLRC 1317
Query: 1126 DGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQC 1185
DG+ DC+D SDE +C+++ C P CA+ V + CD DC DGSDE +C+
Sbjct: 1318 DGEADCQDRSDEADCDAI-CLPNQFRCASGQCVLIKQQ--CDSFPDCIDGSDE-LMCEIT 1373
Query: 1186 S-LNNGGCSHNCSVAPGEGIVCS 1207
++ +H+ ++ P GI+ S
Sbjct: 1374 KPPSDDSPAHSSAIGPVIGIILS 1396
Score = 89.0 bits (219), Expect = 1e-16
Identities = 48/115 (41%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 2694 PRCPLNYFACPSGR--CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQW 2751
P C + FAC +G CIP +W CD +C+ DE C CS AQF C +C+ +
Sbjct: 1257 PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-PVCSAAQFPCARGQCVDLRL 1315
Query: 2752 LCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
CDG DC D SDE A C+ C P+ F C + CV + CD DC DG+DE
Sbjct: 1316 RCDGEADCQDRSDE-ADCDA-ICLPNQFRC-ASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 87.8 bits (216), Expect = 2e-16
Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 22/175 (12%)
Query: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAG---CLYNSTCDDREFMCQNRQ- 2829
C + C +H+C+ + DG C+ + C TC +F C +
Sbjct: 1217 CARDNGGC--SHICIAKG---DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEI 1271
Query: 2830 -CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQS 2888
CIP + CD +C D SDE P C ++F CA G+C+ R CDGE DC D+S
Sbjct: 1272 DCIPGAWRCDGFPECDDQSDEEG---CPVCSAAQFPCARGQCVDLRL-RCDGEADCQDRS 1327
Query: 2889 DEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINE 2943
DEA + C +QF C+SG+CV C+ DC D SDE C I +
Sbjct: 1328 DEADCDAICLP--------NQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
Score = 87.4 bits (215), Expect = 3e-16
Identities = 39/100 (39%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGE 2725
C +W CDG +C D SDE CP C F C G+C+ + CD E DC+
Sbjct: 1273 CIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
Query: 2726 DETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
DE C+ C QF C + +C+ + CD DC DGSDE
Sbjct: 1328 DEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 76.6 bits (187), Expect = 5e-13
Identities = 47/128 (36%), Positives = 64/128 (50%), Gaps = 15/128 (11%)
Query: 3653 TCPLDEFQC--NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCL 3710
TC D+F C C P AW+CDG +C D SDE E C VC + F C + C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGCP--VCSAAQ-FPCARGQ-CV 1311
Query: 3711 WIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDG 3770
+ +CDG +C D +DE DC+ +F C + +C+ +C+ F DC DG
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDAICL-------PNQFRCASGQCVLIKQQCDSFPDCIDG 1364
Query: 3771 SDEEDCSI 3778
SDE C I
Sbjct: 1365 SDELMCEI 1372
Score = 72.0 bits (175), Expect = 1e-11
Identities = 43/109 (39%), Positives = 55/109 (50%), Gaps = 13/109 (11%)
Query: 2854 EYPTCGPSEFRCANGR--CLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFL 2911
E PTC P +F CA G C+ W CDG +C DQSDE P C++ +QF
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGA-WRCDGFPECDDQSDEEGC-PVCSA--------AQFP 1304
Query: 2912 CSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLK 2960
C+ G+CV L C+G+ DC D SDE C CL + S C +K
Sbjct: 1305 CARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIK 1352
Score = 65.1 bits (157), Expect = 2e-09
Identities = 37/82 (45%), Positives = 43/82 (52%), Gaps = 9/82 (10%)
Query: 24 PKTCSPKQFACRD-QITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT 82
P TCSP QFAC +I CI WRCDG +C D SDE E CP C + C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGCPV-----CSAAQFPCARG 1308
Query: 83 ELCVPMSRLCNGVQDCMDGSDE 104
+ CV + C+G DC D SDE
Sbjct: 1309 Q-CVDLRLRCDGEADCQDRSDE 1329
Score = 58.9 bits (141), Expect = 1e-07
Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 10/79 (12%)
Query: 27 CSPKQFAC-RDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
CS QF C R Q C+ RCDGE DC D SDEA C C PN+ C + C
Sbjct: 1298 CSAAQFPCARGQ--CVDLRLRCDGEADCQDRSDEAD--CDAI----CLPNQFRCASGQ-C 1348
Query: 86 VPMSRLCNGVQDCMDGSDE 104
V + + C+ DC+DGSDE
Sbjct: 1349 VLIKQQCDSFPDCIDGSDE 1367
Score = 37.0 bits (84), Expect = 0.45
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 1185 CSLNNGGCSHNCSVAPGEGIV-CSCPLGMELGPDNHTCQIQSYCA 1228
C+ +NGGCSH C +A G+G CSCP+ + L + TC C+
Sbjct: 1217 CARDNGGCSHIC-IAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 538 bits (1386), Expect = e-152
Identities = 292/748 (39%), Positives = 410/748 (54%), Gaps = 59/748 (7%)
Query: 3453 CAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512
C P+QFQC+ RCI +W CD D DCVDGSDE NC + TC +F C ++G+C+P+RW
Sbjct: 33 CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC-NNGQCVPSRW 89
Query: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSDEESC 3570
KCDG+ DC DGSDE E+C RTC ++ C + +C+P W+CD +NDC DEE+C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLR 3629
CS EF+C++GRCI+ + C+G DC+DGSDE DC P C +FQC + CIP+
Sbjct: 150 GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPIS 209
Query: 3630 WRCDADADCMDGSDE--EACGTG--VRT-CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSD 3684
W CD DADC D SDE E CG + T CP E QC + C W+CDG+ DC D SD
Sbjct: 210 WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
Query: 3685 ENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDK 3744
E C C P++ F C+ D C+ RQC+G +C DG+DE +C+ + C
Sbjct: 270 E--VNCPSRTCRPDQ-FECE-DGSCIHGSRQCNGIRDCVDGSDEVNCK----NVNQCLGP 321
Query: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDPKLTSCATNASICGDEARCVRTE 3802
+F CR+ C+ S CN DC D SDE ++C I+ L + + IC D
Sbjct: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYE-- 379
Query: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNT--C 3860
C C +GF + + C DI+EC G CSQ+C N KGG+ C C+R + T C
Sbjct: 380 ----CDCAAGFELIDRKT-CGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
Query: 3861 KAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWH 3920
KA G E +++ + +IR + G Y Q + + A+D + A +++W +
Sbjct: 435 KAVGKEPSLIF-TNRRDIRKI--GLERKEYIQLVE--QLRNTVALDADIAAQKLFWAD-- 487
Query: 3921 TGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRD 3980
+S +++ A+ RH + ID + P IA+DWV +YWTD+
Sbjct: 488 ---LSQKAIFSASIDDKVGRHVKMIDN---------VYNPAAIAVDWVYKTIYWTDAASK 535
Query: 3981 VIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLV 4040
I VA + G RK L + + EP +I VDPL G +YWSDWG KIE A M+G R LV
Sbjct: 536 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 595
Query: 4041 QDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFED 4100
+IQWP G+ +D RLYW D+KL ++ S+ LNG D + S L+HP ++ +FED
Sbjct: 596 TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 655
Query: 4101 YIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK----C 4156
+Y + N V+ +KF S L L L+ A D+++YH+ QP N C+ C
Sbjct: 656 RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGC 715
Query: 4157 EWLCLLSPS----GP--VCTCPNGKRLD 4178
E+LCL +P P C+CP+G ++
Sbjct: 716 EYLCLPAPQINDHSPKYTCSCPSGYNVE 743
Score = 531 bits (1369), Expect = e-150
Identities = 295/748 (39%), Positives = 411/748 (54%), Gaps = 47/748 (6%)
Query: 2602 KTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCE 2661
K C +F+C +G CI +C+ DC D SDE NC C+ + G
Sbjct: 30 KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ------ 83
Query: 2662 RTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACP--SGRCIPMSWTCDKED 2719
C W CDG DC D SDE R C ++ +C S +CIP+SW CD E+
Sbjct: 84 ----CVPSRWKCDGDPDCEDGSDESPEQCHMRT-CRIHEISCGAHSTQCIPVSWRCDGEN 138
Query: 2720 DCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS 2778
DC+ GEDE +C N CS +F C + RCIS+ ++C+G DDC DGSDE C TCG
Sbjct: 139 DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDEL-DCAPPTCGAHE 197
Query: 2779 FSCPGTHVCVPERWLCDGDKDCADGADESIAAGC----LYNSTCDDREFMCQNRQCIPKH 2834
F C T C+P W+CD D DC+D +DES+ C + ++ C E C + +CI K
Sbjct: 198 FQC-STSSCIPISWVCDDDADCSDQSDESLEQ-CGRQPVIHTKCPASEIQCGSGECIHKK 255
Query: 2835 FVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKN 2894
+ CD D DC DGSDE C TC P +F C +G C+ + +C+G DC D SDE
Sbjct: 256 WRCDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV--- 310
Query: 2895 PHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE--RGCHINECLSRKLSGC 2952
+C + ++C +F C SG C+ + +CN + DC D SDE + CHINECL GC
Sbjct: 311 -NCKNV-NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGC 367
Query: 2953 SQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYA 3012
S C+DL IG++C C GF L D +TC D+DEC CSQ CIN G YKC C GY
Sbjct: 368 SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQ 426
Query: 3013 PRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIY 3072
CKAV +EP LIF NR +RK+ L+ Y L + L N VALD D Q ++
Sbjct: 427 MDLATG-VCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLF 484
Query: 3073 WTDVTTQGSMIRRMHLN-GSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL 3131
W D++ + + G +V+++ + NP +AVDWV +YW D TI V+ L
Sbjct: 485 WADLSQKAIFSASIDDKVGRHVKMIDN--VYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
Query: 3132 NGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWP 3191
+G R L +S LREP ++ VD +G++YW+DWG+ + I + GM+G R +V I WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
Query: 3192 NGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS--QDIPHIFALTLFEDYVYWTDW 3249
NG+TLD + R+YW D++ + L+G +R +VL + + H ALT+FED VYW D
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
Query: 3250 ETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCK--VNNGGCSNLCLL 3307
E +++ A+K TG+ L++ L+ D+ V+H L QP N C+ + NGGC LCL
Sbjct: 663 ENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDMENGGCEYLCLP 721
Query: 3308 SP-----GGGHKCACPTNFYLGSDGRTC 3330
+P + C+CP+ + + +GR C
Sbjct: 722 APQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 521 bits (1341), Expect = e-147
Identities = 283/739 (38%), Positives = 397/739 (53%), Gaps = 34/739 (4%)
Query: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
+C+P +F C N RCI WKCDGD DC+D SDE C + TC F C N +C+P+RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNGQCVPSRW 89
Query: 913 LCDGDNDCGNSEDESNATCSARTCPPNQFSCA--SGRCIPISWTCDLDDDCGDRSDESAS 970
CDGD DC + DES C RTC ++ SC S +CIP+SW CD ++DC DE +
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE-N 148
Query: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSH-SCSSTQFKCNSGRCIP 1029
C TC P +FTC++GRCI+ N+ C+ +DC D SDE C+ +C + +F+C++ CIP
Sbjct: 149 CGNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
Query: 1030 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCM 1089
W CD D DC D SDE+ C Q C E QC G CI +WRCDGD DC
Sbjct: 208 ISWVCDDDADCSDQSDESLEQCGRQPVIHTK-CPASEIQCG-SGECIHKKWRCDGDPDCK 265
Query: 1090 DSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRP 1147
D SDE +C T C P +F C+D + CI + C+G DC D SDE NC+++ P
Sbjct: 266 DGSDEVNCPSRT--CRPD-QFECEDGS-CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 1148 PSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG-ELC--DQCSLNNGGCSHNCSVAPGEGI 1204
C + C+ K+C+ DC D SDE + C ++C +NNGGCSH C G
Sbjct: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
Query: 1205 VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264
C C G EL D TC C CSQ C K KC C G+ ++ C+++
Sbjct: 379 ECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 1265 DPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
+P +IF+NR +IR+I L + +Y LV LRNT+ALD ++ L+W D+ + I+
Sbjct: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
Query: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAG 1384
+ D V + + P +AVDW+ IYW ++ I VA LDGT R L
Sbjct: 497 SIDDK---VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
Query: 1385 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYL 1444
D+ P +IA+DP G ++W+DW +IE A M+G RR + T WPNG+T+D +
Sbjct: 554 DLREPASIAVDPLSGFVYWSDWGEPA-KIEKAGMNGFDRRPL--VTADIQWPNGITLDLI 610
Query: 1445 EKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKA 1504
+ R+ W+D++ + S +G VL+ EFL+HP A+T++ VYW D + A
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
Query: 1505 NKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCL----IN-YNR 1559
NK+TG + + D+ VYH QP N CE + G C +LCL IN ++
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSP 730
Query: 1560 TVSCACPHLMKLHKDNTTC 1578
+C+CP + ++ C
Sbjct: 731 KYTCSCPSGYNVEENGRDC 749
Score = 302 bits (773), Expect = 6e-81
Identities = 156/423 (36%), Positives = 228/423 (53%), Gaps = 36/423 (8%)
Query: 3324 GSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST 3383
G+ G + C SQF C N +CI WKCD ++DC D SDE +C + C F C+
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNN 81
Query: 3384 GICTNPAFICDGDNDCQDNSDEA--NCDIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCG 3440
G C + CDGD DC+D SDE+ C + C + C ++ +CIP +RC+G+++C
Sbjct: 82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
Query: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
GEDE +C +TC+P++F CS + RCI R +VC+ +DC DGSDE +C TCG EF+
Sbjct: 142 SGEDEENCGNITCSPDEFTCS-SGRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQ 199
Query: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDER-----TCEPYQFRCKNNRCVPGRWQC 3555
C S CIP W CD + DC D SDE E+C + C + +C + C+ +W+C
Sbjct: 200 CSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRC 258
Query: 3556 DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC--TPRC 3613
D D DC D SDE +C R C +F C +G CI G +C+G DC DGSDE +C +C
Sbjct: 259 DGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC 318
Query: 3614 -DMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL--A 3670
+F+C+SG CI + C+ + DC D SDE + C ++ C++ +CK L
Sbjct: 319 LGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIG 377
Query: 3671 WKCD--------GEDDCGDNSD-ENPEECARFVCPPNRPFRCKNDR---------VCLWI 3712
++CD CGD + +NP C++ ++C+ R VC +
Sbjct: 378 YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 3713 GRQ 3715
G++
Sbjct: 438 GKE 440
Score = 298 bits (762), Expect = 1e-79
Identities = 160/392 (40%), Positives = 208/392 (53%), Gaps = 28/392 (7%)
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFR 3432
KC P QFQC+ G C + CDGD DC D SDE NC C S F C N +C+P ++
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWK 90
Query: 3433 CNGQDNCGDGEDE--RDCPEVTCAPNQFQCSI-TKRCIPRVWVCDRDNDCVDGSDEPANC 3489
C+G +C DG DE C TC ++ C + +CIP W CD +NDC G DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
Query: 3490 TQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCV 3549
+TC DEF C SGRCI + C+G+DDC DGSDE +C TC ++F+C + C+
Sbjct: 150 GNITCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
Query: 3550 PGRWQCDYDNDCGDNSDE--ESCTPRP-----CSESEFSCANGRCIAGRWKCDGDHDCAD 3602
P W CD D DC D SDE E C +P C SE C +G CI +W+CDGD DC D
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
Query: 3603 GSDEKDCTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQC 3661
GSDE +C R C DQF+C+ G CI +C+ DC+DGSDE C + +F+C
Sbjct: 267 GSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC 326
Query: 3662 NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCD---- 3717
+ C ++ C+ E DC D SDE +EC C N C + L IG +CD
Sbjct: 327 RSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNG-GCSHICKDLVIGYECDCAAG 385
Query: 3718 ----GTDNCGDGTDEEDCEPPTAHTTHCKDKK 3745
CG D ++C+ P + C + K
Sbjct: 386 FELIDRKTCG---DIDECQNPGICSQICINLK 414
Score = 259 bits (661), Expect = 6e-68
Identities = 147/384 (38%), Positives = 190/384 (49%), Gaps = 33/384 (8%)
Query: 3314 KCACPTNFYLGSDGRTCVSN-CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPD-CPE 3371
KC + GSD + CV C S FVC N +C+P WKCD + DC D SDE P+ C
Sbjct: 51 KCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM 110
Query: 3372 FKCRPGQFQCS--TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPG 3429
CR + C + C ++ CDG+NDC DE NC C P +F C ++ RCI
Sbjct: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTC-SSGRCISR 169
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN- 3488
F CNGQD+C DG DE DC TC ++FQCS T CIP WVCD D DC D SDE
Sbjct: 170 NFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLEQ 228
Query: 3489 -----CTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC 3543
C E +C SG CI +W+CDG+ DC DGSDE C RTC P QF C
Sbjct: 229 CGRQPVIHTKCPASEIQC-GSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFEC 285
Query: 3544 KNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCIAGRWKCDGDHDCA 3601
++ C+ G QC+ DC D SDE +C + +F C +G CI C+ + DC
Sbjct: 286 EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCR 345
Query: 3602 DGSDEKDCTPRCDMDQFQCKSGHC------IPLRWRCDADADCMDGSDEEACGTGVRTCP 3655
D SDE C +++ +G C + + + CD A + D + CG
Sbjct: 346 DWSDEP--LKECHINECLVNNGGCSHICKDLVIGYECDCAAG-FELIDRKTCG------D 396
Query: 3656 LDEFQCNNTLCKPLAWKCDGEDDC 3679
+DE Q N +C + G C
Sbjct: 397 IDECQ-NPGICSQICINLKGGYKC 419
Score = 244 bits (622), Expect = 2e-63
Identities = 158/504 (31%), Positives = 251/504 (49%), Gaps = 35/504 (6%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
+TC P QF C D +CI +C+G RDC DGSDE + ++ Q P + C E
Sbjct: 276 RTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSGE- 330
Query: 85 CVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
C+ +S++CN QDC D SDE C + + GC H C + G C C + F+L
Sbjct: 331 CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL-I 389
Query: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLI 203
D KTC D DEC G CSQ+C N G + C C GY + CKA V + P L+
Sbjct: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIF 445
Query: 204 ANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPG 263
N ++I L + + R T A+D A + + W + A +
Sbjct: 446 TNRRDIRKIGLERKEYIQLVE-QLRNTVALDADIAAQKLFWADLSQKAIFSA-------S 497
Query: 264 LKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELY 323
+ V H I ++++ +A+DW+ Y+ D I V +G L + +L
Sbjct: 498 IDDKVGRHVKMID-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
Query: 324 NPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYW 383
P IA+DP G V+++D+G+ K+E+ M+G +R LV + I +P+GITLDL+ +YW
Sbjct: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
Query: 384 ADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV 442
D+ L + VD G+ R+ +++ + + H LT+FE+ +Y + +N +V
Sbjct: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN------EAVYGA 670
Query: 443 NRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NS 498
N+F +E +V ++ + +YH+ QP ++ CE D + GGC +CL A N
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDM--ENGGCEYLCLPAPQIND 727
Query: 499 HKAR-TCRCRSGFSLGSDGKSCKK 521
H + TC C SG+++ +G+ C++
Sbjct: 728 HSPKYTCSCPSGYNVEENGRDCQR 751
Score = 216 bits (551), Expect = 3e-55
Identities = 143/424 (33%), Positives = 194/424 (45%), Gaps = 49/424 (11%)
Query: 2477 CELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGE 2536
CE S + NG C L L G +C D+ C V +C A+ +F C NG+
Sbjct: 33 CEPSQFQCTNGRCITL-LWKCDGDEDCVDGS-----DEKNC--VKKTC-AESDFVCNNGQ 83
Query: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS--NGRCVSNMLWCNGADDCGDG 2594
C+ CDG P C+D SDE P C+ R C+ C + +C+ C+G +DC G
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
Query: 2595 SDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG 2654
DE C C EF C G CI + CN DC D SDE++C+ C ++
Sbjct: 144 EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH------- 196
Query: 2655 VLFQPCERTSLCYAPSWVCDGANDCGDYSDE--RDC--PGVKRPRCPLNYFACPSGRCIP 2710
FQ C TS C SWVCD DC D SDE C V +CP + C SG CI
Sbjct: 197 -EFQ-CS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
Query: 2711 MSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC 2769
W CD + DC+ G DE +C ++ C QFEC++ CI C+G DC DGSDE +C
Sbjct: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE-VNC 312
Query: 2770 E--GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQN 2827
+ + GP F C C+ +C+ ++DC D +DE + C E + N
Sbjct: 313 KNVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDEPL-------KECHINECLVNN 364
Query: 2828 RQC--IPKHFVCDHDRDCADGSD--------ESPECEYP-TCGPSEFRCANG-RCLSSRQ 2875
C I K V ++ DCA G + + EC+ P C G +C SR
Sbjct: 365 GGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
Query: 2876 WECD 2879
++ D
Sbjct: 425 YQMD 428
Score = 164 bits (415), Expect = 2e-39
Identities = 117/372 (31%), Positives = 177/372 (47%), Gaps = 30/372 (8%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ PG CS IC+ N C C G+ + CK E L++ R IR
Sbjct: 398 DECQNPGICSQICI--NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD--IRK 453
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG-TERETILKD 599
+ + K E++ +E L N ALD +++AD + I ID R + D
Sbjct: 454 IGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
Query: 600 GIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLN 659
++N +AVDW+ +YWTD KTISVA L+ RK L + P +I VDPL+
Sbjct: 511 NVYNPAAIAVDWVYKTIYWTD-AASKTISVATLD--GTKRKFLFNSDLREPASIAVDPLS 567
Query: 660 GWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAF 719
G++YW+DW E K +E+A M+G R VT+ + WPNG++LD+ RLYW+D+
Sbjct: 568 GFVYWSDWGEPAK------IEKAGMNGFDRRPLVTAD-IQWPNGITLDLIKSRLYWLDSK 620
Query: 720 YDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPT 778
+ ++ LNG DR+IV + E L H L + ++W + + +VY + G T
Sbjct: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
Query: 779 VTLLRSERPPIFEIRMYDAQQQQVGTNKCR--VNNGGCSSLCLATPGSRQ------CACA 830
+ ++ +I +Y Q G N C + NGGC LCL P C+C
Sbjct: 681 LVNNLNDAQ---DIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Query: 831 EDQVLDADGVTC 842
++ +G C
Sbjct: 738 SGYNVEENGRDC 749
Score = 162 bits (410), Expect = 7e-39
Identities = 105/357 (29%), Positives = 177/357 (49%), Gaps = 22/357 (6%)
Query: 1853 NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPND 1910
N G CSQ+C+ + C C+ GY + C+ VG L+++ IR I L+ +
Sbjct: 402 NPGICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1911 KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAK-RDQTWREDVVTNGIGRVEG 1969
+ + T V +D ++W D+ I A D+ R + + +
Sbjct: 461 YIQLVEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAA 517
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
IAVDW+ IYWTD I VA L+G+ R + + L +P +I V P G+++W++WG+
Sbjct: 518 IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE++ ++G +R LV I WPNGI++D +LYW D++ + +DL G++R +
Sbjct: 578 PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRI 636
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
VL S ++++FED +YW D N ++ +K ++ L + +DI V
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLN-DAQDIIV 693
Query: 2148 FNRDRQ-KGTNVCA--VANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCR 2195
++ Q G N C + NGGC+ LCL + + C+C G + E+G C+
Sbjct: 694 YHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
Score = 147 bits (371), Expect = 2e-34
Identities = 93/268 (34%), Positives = 123/268 (45%), Gaps = 39/268 (14%)
Query: 799 QQQVGTNKCRVNNGGCSS-LCLATPGSRQCAC-AEDQVLD-ADGVTCLANPSYVPPPQCQ 855
++ G C + CSS C+ SR C +D D +D + C PP C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCI----SRNFVCNGQDDCSDGSDELDCA-------PPTCG 194
Query: 856 PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ----HT-CPSDRFKCENNRCIPN 910
EF C+ S CI W CD D DC D SDE+ C + HT CP+ +C + CI
Sbjct: 195 AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHK 254
Query: 911 RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970
+W CDGD DC + DE N C +RTC P+QF C G CI S C+ DC D SDE
Sbjct: 255 KWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Query: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE--------------AGCSHSCS 1016
C +F C +G CI+I+ C+ + DC D SDE GCSH C
Sbjct: 313 KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICK 372
Query: 1017 ST----QFKCNSGRCIPEHWTCDGDNDC 1040
+ C +G + + TC ++C
Sbjct: 373 DLVIGYECDCAAGFELIDRKTCGDIDEC 400
Score = 146 bits (369), Expect = 4e-34
Identities = 99/356 (27%), Positives = 166/356 (46%), Gaps = 20/356 (5%)
Query: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYN 1604
G CS +C IN C C ++ C K L++ + +IR + L+ Y
Sbjct: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING-TGVETVVSADLPNAHGL 1663
++ + N LD D Q+++W+D+ +AI A I+ G + ++ N +
Sbjct: 463 QLVE----QLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTDGD 1722
AVDWV + ++WT D K I+VA LDG+ + + L +P + V PL G +YW+D
Sbjct: 519 AVDWVYKTIYWT--DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
Query: 1723 N---ISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778
I A M+G +R L + + P G+ +D +S+LYW+ S H ++ +L+G +
Sbjct: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
Query: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838
+ L AL I D+++W D +E + +K GS L N+ + VY E
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
Query: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETT-----RSCMCTAGYSLRSGQQACEGV 1889
+Q K + NG C LCLP + +C C +GY++ + C+ +
Sbjct: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI 752
Score = 120 bits (302), Expect = 2e-26
Identities = 93/375 (24%), Positives = 167/375 (44%), Gaps = 42/375 (11%)
Query: 2164 GGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGY---LLYSERTILKSIHLSDERNL 2220
G C Q+C+ G + C C+ G + + G L+++ R ++ I L + +
Sbjct: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI--QQINDDGSRRITI 2278
E ++N +AL D A ++F++D+ I I+D R + +
Sbjct: 463 QLV-------EQLRNTVALDADIAA-------QKLFWADLSQKAIFSASIDDKVGRHVKM 508
Query: 2279 VENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFV 2338
++NV + +A + T+YWT + TI+ T+D T+ + S P +
Sbjct: 509 IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIA 562
Query: 2339 LDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2398
+D ++W++W E I +A ++G + L+ DI+ PNG+ +D +LY+ D+ L
Sbjct: 563 VDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKL 621
Query: 2399 DKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLL 2456
+ + +G R ++LKS HP L ++ + ++W D AV ANK GS + L
Sbjct: 622 HMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681
Query: 2457 RVDIPQQPMGII----AVANDTNSCELSPCRINNGGCQDLCLLT-----HQGHVNCSCRG 2507
++ I+ + N CE + NGGC+ LCL H CSC
Sbjct: 682 VNNLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPS 738
Query: 2508 G-RILQDDLTCRAVN 2521
G + ++ C+ +N
Sbjct: 739 GYNVEENGRDCQRIN 753
Score = 73.9 bits (180), Expect = 3e-12
Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-LGTE 83
KTC+ F C + C+ W+CDG+ DC DGSDE+PE C + C+ +E +C +
Sbjct: 70 KTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQC---HMRTCRIHEISCGAHST 125
Query: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
C+P+S C+G DC G DE NC + C P + SS + +
Sbjct: 126 QCIPVSWRCDGENDCDSGEDE--------ENCGNITC---------SPDEFTCSSGRCIS 168
Query: 144 DGKTCKDFDECS 155
C D+CS
Sbjct: 169 RNFVCNGQDDCS 180
Score = 68.6 bits (166), Expect = 1e-10
Identities = 56/180 (31%), Positives = 77/180 (42%), Gaps = 27/180 (15%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
TCSP +F C CIS+ + C+G+ DC DGSDE P C +E C T C
Sbjct: 153 TCSPDEFTCSSG-RCISRNFVCNGQDDCSDGSDELDCAPP-----TCGAHEFQC-STSSC 205
Query: 86 VPMSRLCNGVQDCMDGSDEG-----------PHCRELQGNCSRLGCQHHCVPTLDGPTCY 134
+P+S +C+ DC D SDE C + C C H P C
Sbjct: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
Query: 135 CNSSFQLQADGKTCK-DFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
+ S ++ +TC+ D EC G+C +G I CV+G D +CK N+
Sbjct: 266 -DGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNG--IRDCVDG----SDEVNCKNVNQ 317
Score = 67.0 bits (162), Expect = 4e-10
Identities = 38/104 (36%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
C P QF C + CI+ W+CDG+ DC DGSDE + C ++ C + CV
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-----KNCVKKTCAESDFVCNNGQ-CV 85
Query: 87 PMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---CVP 126
P C+G DC DGSDE P C + C H C+P
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
Score = 33.5 bits (75), Expect = 5.0
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACA 830
D ++ N+C VNNGGCS +C +C CA
Sbjct: 349 DEPLKECHINECLVNNGGCSHICKDLVIGYECDCA 383
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 538 bits (1386), Expect = e-152
Identities = 292/748 (39%), Positives = 410/748 (54%), Gaps = 59/748 (7%)
Query: 3453 CAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512
C P+QFQC+ RCI +W CD D DCVDGSDE NC + TC +F C ++G+C+P+RW
Sbjct: 33 CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC-NNGQCVPSRW 89
Query: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSDEESC 3570
KCDG+ DC DGSDE E+C RTC ++ C + +C+P W+CD +NDC DEE+C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLR 3629
CS EF+C++GRCI+ + C+G DC+DGSDE DC P C +FQC + CIP+
Sbjct: 150 GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPIS 209
Query: 3630 WRCDADADCMDGSDE--EACGTG--VRT-CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSD 3684
W CD DADC D SDE E CG + T CP E QC + C W+CDG+ DC D SD
Sbjct: 210 WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
Query: 3685 ENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDK 3744
E C C P++ F C+ D C+ RQC+G +C DG+DE +C+ + C
Sbjct: 270 E--VNCPSRTCRPDQ-FECE-DGSCIHGSRQCNGIRDCVDGSDEVNCK----NVNQCLGP 321
Query: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDPKLTSCATNASICGDEARCVRTE 3802
+F CR+ C+ S CN DC D SDE ++C I+ L + + IC D
Sbjct: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYE-- 379
Query: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNT--C 3860
C C +GF + + C DI+EC G CSQ+C N KGG+ C C+R + T C
Sbjct: 380 ----CDCAAGFELIDRKT-CGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
Query: 3861 KAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWH 3920
KA G E +++ + +IR + G Y Q + + A+D + A +++W +
Sbjct: 435 KAVGKEPSLIF-TNRRDIRKI--GLERKEYIQLVE--QLRNTVALDADIAAQKLFWAD-- 487
Query: 3921 TGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRD 3980
+S +++ A+ RH + ID + P IA+DWV +YWTD+
Sbjct: 488 ---LSQKAIFSASIDDKVGRHVKMIDN---------VYNPAAIAVDWVYKTIYWTDAASK 535
Query: 3981 VIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLV 4040
I VA + G RK L + + EP +I VDPL G +YWSDWG KIE A M+G R LV
Sbjct: 536 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 595
Query: 4041 QDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFED 4100
+IQWP G+ +D RLYW D+KL ++ S+ LNG D + S L+HP ++ +FED
Sbjct: 596 TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 655
Query: 4101 YIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK----C 4156
+Y + N V+ +KF S L L L+ A D+++YH+ QP N C+ C
Sbjct: 656 RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGC 715
Query: 4157 EWLCLLSPS----GP--VCTCPNGKRLD 4178
E+LCL +P P C+CP+G ++
Sbjct: 716 EYLCLPAPQINDHSPKYTCSCPSGYNVE 743
Score = 534 bits (1376), Expect = e-151
Identities = 297/753 (39%), Positives = 413/753 (54%), Gaps = 47/753 (6%)
Query: 2602 KTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCE 2661
K C +F+C +G CI +C+ DC D SDE NC C+ + G
Sbjct: 30 KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ------ 83
Query: 2662 RTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACP--SGRCIPMSWTCDKED 2719
C W CDG DC D SDE R C ++ +C S +CIP+SW CD E+
Sbjct: 84 ----CVPSRWKCDGDPDCEDGSDESPEQCHMRT-CRIHEISCGAHSTQCIPVSWRCDGEN 138
Query: 2720 DCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS 2778
DC+ GEDE +C N CS +F C + RCIS+ ++C+G DDC DGSDE C TCG
Sbjct: 139 DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDEL-DCAPPTCGAHE 197
Query: 2779 FSCPGTHVCVPERWLCDGDKDCADGADESIAAGC----LYNSTCDDREFMCQNRQCIPKH 2834
F C T C+P W+CD D DC+D +DES+ C + ++ C E C + +CI K
Sbjct: 198 FQC-STSSCIPISWVCDDDADCSDQSDESLEQ-CGRQPVIHTKCPASEIQCGSGECIHKK 255
Query: 2835 FVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKN 2894
+ CD D DC DGSDE C TC P +F C +G C+ + +C+G DC D SDE
Sbjct: 256 WRCDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV--- 310
Query: 2895 PHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE--RGCHINECLSRKLSGC 2952
+C + ++C +F C SG C+ + +CN + DC D SDE + CHINECL GC
Sbjct: 311 -NCKNV-NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGC 367
Query: 2953 SQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYA 3012
S C+DL IG++C C GF L D +TC D+DEC CSQ CIN G YKC C GY
Sbjct: 368 SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQ 426
Query: 3013 PRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIY 3072
CKAV +EP LIF NR +RK+ L+ Y L + L N VALD D Q ++
Sbjct: 427 MDLATG-VCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLF 484
Query: 3073 WTDVTTQGSMIRRMHLN-GSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL 3131
W D++ + + G +V+++ + NP +AVDWV +YW D TI V+ L
Sbjct: 485 WADLSQKAIFSASIDDKVGRHVKMIDN--VYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
Query: 3132 NGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWP 3191
+G R L +S LREP ++ VD +G++YW+DWG+ + I + GM+G R +V I WP
Sbjct: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
Query: 3192 NGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLS--QDIPHIFALTLFEDYVYWTDW 3249
NG+TLD + R+YW D++ + L+G +R +VL + + H ALT+FED VYW D
Sbjct: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
Query: 3250 ETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCK--VNNGGCSNLCLL 3307
E +++ A+K TG+ L++ L+ D+ V+H L QP N C+ + NGGC LCL
Sbjct: 663 ENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDMENGGCEYLCLP 721
Query: 3308 SP-----GGGHKCACPTNFYLGSDGRTCVSNCT 3335
+P + C+CP+ + + +GR C S T
Sbjct: 722 APQINDHSPKYTCSCPSGYNVEENGRDCQSTAT 754
Score = 523 bits (1347), Expect = e-147
Identities = 285/761 (37%), Positives = 404/761 (53%), Gaps = 34/761 (4%)
Query: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
+C+P +F C N RCI WKCDGD DC+D SDE C + TC F C N +C+P+RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNGQCVPSRW 89
Query: 913 LCDGDNDCGNSEDESNATCSARTCPPNQFSCA--SGRCIPISWTCDLDDDCGDRSDESAS 970
CDGD DC + DES C RTC ++ SC S +CIP+SW CD ++DC DE +
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE-N 148
Query: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSH-SCSSTQFKCNSGRCIP 1029
C TC P +FTC++GRCI+ N+ C+ +DC D SDE C+ +C + +F+C++ CIP
Sbjct: 149 CGNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
Query: 1030 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCM 1089
W CD D DC D SDE+ C Q C E QC G CI +WRCDGD DC
Sbjct: 208 ISWVCDDDADCSDQSDESLEQCGRQPVIHTK-CPASEIQCG-SGECIHKKWRCDGDPDCK 265
Query: 1090 DSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRP 1147
D SDE +C T C P +F C+D + CI + C+G DC D SDE NC+++ P
Sbjct: 266 DGSDEVNCPSRT--CRPD-QFECEDGS-CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 1148 PSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG-ELC--DQCSLNNGGCSHNCSVAPGEGI 1204
C + C+ K+C+ DC D SDE + C ++C +NNGGCSH C G
Sbjct: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
Query: 1205 VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264
C C G EL D TC C CSQ C K KC C G+ ++ C+++
Sbjct: 379 ECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 1265 DPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
+P +IF+NR +IR+I L + +Y LV LRNT+ALD ++ L+W D+ + I+
Sbjct: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
Query: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAG 1384
+ D V + + P +AVDW+ IYW ++ I VA LDGT R L
Sbjct: 497 SIDDK---VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
Query: 1385 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYL 1444
D+ P +IA+DP G ++W+DW +IE A M+G RR + T WPNG+T+D +
Sbjct: 554 DLREPASIAVDPLSGFVYWSDWGEPA-KIEKAGMNGFDRRPL--VTADIQWPNGITLDLI 610
Query: 1445 EKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKA 1504
+ R+ W+D++ + S +G VL+ EFL+HP A+T++ VYW D + A
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
Query: 1505 NKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCL----IN-YNR 1559
NK+TG + + D+ VYH QP N CE + G C +LCL IN ++
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSP 730
Query: 1560 TVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDA 1600
+C+CP + ++ C + Y+ + ++ A
Sbjct: 731 KYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISA 771
Score = 302 bits (773), Expect = 6e-81
Identities = 156/423 (36%), Positives = 228/423 (53%), Gaps = 36/423 (8%)
Query: 3324 GSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST 3383
G+ G + C SQF C N +CI WKCD ++DC D SDE +C + C F C+
Sbjct: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNN 81
Query: 3384 GICTNPAFICDGDNDCQDNSDEA--NCDIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCG 3440
G C + CDGD DC+D SDE+ C + C + C ++ +CIP +RC+G+++C
Sbjct: 82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
Query: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
GEDE +C +TC+P++F CS + RCI R +VC+ +DC DGSDE +C TCG EF+
Sbjct: 142 SGEDEENCGNITCSPDEFTCS-SGRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQ 199
Query: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDER-----TCEPYQFRCKNNRCVPGRWQC 3555
C S CIP W CD + DC D SDE E+C + C + +C + C+ +W+C
Sbjct: 200 CSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRC 258
Query: 3556 DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC--TPRC 3613
D D DC D SDE +C R C +F C +G CI G +C+G DC DGSDE +C +C
Sbjct: 259 DGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC 318
Query: 3614 -DMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL--A 3670
+F+C+SG CI + C+ + DC D SDE + C ++ C++ +CK L
Sbjct: 319 LGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIG 377
Query: 3671 WKCD--------GEDDCGDNSD-ENPEECARFVCPPNRPFRCKNDR---------VCLWI 3712
++CD CGD + +NP C++ ++C+ R VC +
Sbjct: 378 YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
Query: 3713 GRQ 3715
G++
Sbjct: 438 GKE 440
Score = 298 bits (762), Expect = 1e-79
Identities = 160/392 (40%), Positives = 208/392 (53%), Gaps = 28/392 (7%)
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFR 3432
KC P QFQC+ G C + CDGD DC D SDE NC C S F C N +C+P ++
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWK 90
Query: 3433 CNGQDNCGDGEDE--RDCPEVTCAPNQFQCSI-TKRCIPRVWVCDRDNDCVDGSDEPANC 3489
C+G +C DG DE C TC ++ C + +CIP W CD +NDC G DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
Query: 3490 TQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCV 3549
+TC DEF C SGRCI + C+G+DDC DGSDE +C TC ++F+C + C+
Sbjct: 150 GNITCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
Query: 3550 PGRWQCDYDNDCGDNSDE--ESCTPRP-----CSESEFSCANGRCIAGRWKCDGDHDCAD 3602
P W CD D DC D SDE E C +P C SE C +G CI +W+CDGD DC D
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
Query: 3603 GSDEKDCTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQC 3661
GSDE +C R C DQF+C+ G CI +C+ DC+DGSDE C + +F+C
Sbjct: 267 GSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC 326
Query: 3662 NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCD---- 3717
+ C ++ C+ E DC D SDE +EC C N C + L IG +CD
Sbjct: 327 RSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNG-GCSHICKDLVIGYECDCAAG 385
Query: 3718 ----GTDNCGDGTDEEDCEPPTAHTTHCKDKK 3745
CG D ++C+ P + C + K
Sbjct: 386 FELIDRKTCG---DIDECQNPGICSQICINLK 414
Score = 259 bits (661), Expect = 6e-68
Identities = 147/384 (38%), Positives = 190/384 (49%), Gaps = 33/384 (8%)
Query: 3314 KCACPTNFYLGSDGRTCVSN-CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPD-CPE 3371
KC + GSD + CV C S FVC N +C+P WKCD + DC D SDE P+ C
Sbjct: 51 KCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM 110
Query: 3372 FKCRPGQFQCS--TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPG 3429
CR + C + C ++ CDG+NDC DE NC C P +F C ++ RCI
Sbjct: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTC-SSGRCISR 169
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN- 3488
F CNGQD+C DG DE DC TC ++FQCS T CIP WVCD D DC D SDE
Sbjct: 170 NFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLEQ 228
Query: 3489 -----CTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC 3543
C E +C SG CI +W+CDG+ DC DGSDE C RTC P QF C
Sbjct: 229 CGRQPVIHTKCPASEIQC-GSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFEC 285
Query: 3544 KNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCIAGRWKCDGDHDCA 3601
++ C+ G QC+ DC D SDE +C + +F C +G CI C+ + DC
Sbjct: 286 EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCR 345
Query: 3602 DGSDEKDCTPRCDMDQFQCKSGHC------IPLRWRCDADADCMDGSDEEACGTGVRTCP 3655
D SDE C +++ +G C + + + CD A + D + CG
Sbjct: 346 DWSDEP--LKECHINECLVNNGGCSHICKDLVIGYECDCAAG-FELIDRKTCG------D 396
Query: 3656 LDEFQCNNTLCKPLAWKCDGEDDC 3679
+DE Q N +C + G C
Sbjct: 397 IDECQ-NPGICSQICINLKGGYKC 419
Score = 243 bits (620), Expect = 3e-63
Identities = 158/503 (31%), Positives = 250/503 (49%), Gaps = 35/503 (6%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
+TC P QF C D +CI +C+G RDC DGSDE + ++ Q P + C E
Sbjct: 276 RTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSGE- 330
Query: 85 CVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
C+ +S++CN QDC D SDE C + + GC H C + G C C + F+L
Sbjct: 331 CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL-I 389
Query: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLI 203
D KTC D DEC G CSQ+C N G + C C GY + CKA V + P L+
Sbjct: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIF 445
Query: 204 ANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPG 263
N ++I L + + R T A+D A + + W + A +
Sbjct: 446 TNRRDIRKIGLERKEYIQLVE-QLRNTVALDADIAAQKLFWADLSQKAIFSA-------S 497
Query: 264 LKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELY 323
+ V H I ++++ +A+DW+ Y+ D I V +G L + +L
Sbjct: 498 IDDKVGRHVKMID-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
Query: 324 NPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYW 383
P IA+DP G V+++D+G+ K+E+ M+G +R LV + I +P+GITLDL+ +YW
Sbjct: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
Query: 384 ADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV 442
D+ L + VD G+ R+ +++ + + H LT+FE+ +Y + +N +V
Sbjct: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN------EAVYGA 670
Query: 443 NRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NS 498
N+F +E +V ++ + +YH+ QP ++ CE D + GGC +CL A N
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDM--ENGGCEYLCLPAPQIND 727
Query: 499 HKAR-TCRCRSGFSLGSDGKSCK 520
H + TC C SG+++ +G+ C+
Sbjct: 728 HSPKYTCSCPSGYNVEENGRDCQ 750
Score = 216 bits (551), Expect = 3e-55
Identities = 143/424 (33%), Positives = 194/424 (45%), Gaps = 49/424 (11%)
Query: 2477 CELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGE 2536
CE S + NG C L L G +C D+ C V +C A+ +F C NG+
Sbjct: 33 CEPSQFQCTNGRCITL-LWKCDGDEDCVDGS-----DEKNC--VKKTC-AESDFVCNNGQ 83
Query: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS--NGRCVSNMLWCNGADDCGDG 2594
C+ CDG P C+D SDE P C+ R C+ C + +C+ C+G +DC G
Sbjct: 84 CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
Query: 2595 SDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG 2654
DE C C EF C G CI + CN DC D SDE++C+ C ++
Sbjct: 144 EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH------- 196
Query: 2655 VLFQPCERTSLCYAPSWVCDGANDCGDYSDE--RDC--PGVKRPRCPLNYFACPSGRCIP 2710
FQ C TS C SWVCD DC D SDE C V +CP + C SG CI
Sbjct: 197 -EFQ-CS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
Query: 2711 MSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC 2769
W CD + DC+ G DE +C ++ C QFEC++ CI C+G DC DGSDE +C
Sbjct: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE-VNC 312
Query: 2770 E--GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQN 2827
+ + GP F C C+ +C+ ++DC D +DE + C E + N
Sbjct: 313 KNVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDEPL-------KECHINECLVNN 364
Query: 2828 RQC--IPKHFVCDHDRDCADGSD--------ESPECEYP-TCGPSEFRCANG-RCLSSRQ 2875
C I K V ++ DCA G + + EC+ P C G +C SR
Sbjct: 365 GGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
Query: 2876 WECD 2879
++ D
Sbjct: 425 YQMD 428
Score = 167 bits (424), Expect = 2e-40
Identities = 109/367 (29%), Positives = 182/367 (49%), Gaps = 22/367 (5%)
Query: 1853 NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPND 1910
N G CSQ+C+ + C C+ GY + C+ VG L+++ IR I L+ +
Sbjct: 402 NPGICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
Query: 1911 KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAK-RDQTWREDVVTNGIGRVEG 1969
+ + T V +D ++W D+ I A D+ R + + +
Sbjct: 461 YIQLVEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAA 517
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
IAVDW+ IYWTD I VA L+G+ R + + L +P +I V P G+++W++WG+
Sbjct: 518 IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE++ ++G +R LV I WPNGI++D +LYW D++ + +DL G++R +
Sbjct: 578 PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRI 636
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
VL S ++++FED +YW D N ++ +K ++ L + +DI V
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLN-DAQDIIV 693
Query: 2148 FNRDRQ-KGTNVCA--VANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCREYA 2198
++ Q G N C + NGGC+ LCL + + C+C G + E+G C+ A
Sbjct: 694 YHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTA 753
Query: 2199 GYLLYSE 2205
+ YSE
Sbjct: 754 TTVTYSE 760
Score = 164 bits (416), Expect = 1e-39
Identities = 118/379 (31%), Positives = 180/379 (47%), Gaps = 30/379 (7%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ PG CS IC+ N C C G+ + CK E L++ R IR
Sbjct: 398 DECQNPGICSQICI--NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD--IRK 453
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG-TERETILKD 599
+ + K E++ +E L N ALD +++AD + I ID R + D
Sbjct: 454 IGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
Query: 600 GIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLN 659
++N +AVDW+ +YWTD KTISVA L+ RK L + P +I VDPL+
Sbjct: 511 NVYNPAAIAVDWVYKTIYWTD-AASKTISVATLD--GTKRKFLFNSDLREPASIAVDPLS 567
Query: 660 GWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAF 719
G++YW+DW E K +E+A M+G R VT+ + WPNG++LD+ RLYW+D+
Sbjct: 568 GFVYWSDWGEPAK------IEKAGMNGFDRRPLVTAD-IQWPNGITLDLIKSRLYWLDSK 620
Query: 720 YDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPT 778
+ ++ LNG DR+IV + E L H L + ++W + + +VY + G T
Sbjct: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
Query: 779 VTLLRSERPPIFEIRMYDAQQQQVGTNKCR--VNNGGCSSLCLATPGSRQ------CACA 830
+ ++ +I +Y Q G N C + NGGC LCL P C+C
Sbjct: 681 LVNNLNDAQ---DIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Query: 831 EDQVLDADGVTCLANPSYV 849
++ +G C + + V
Sbjct: 738 SGYNVEENGRDCQSTATTV 756
Score = 150 bits (378), Expect = 4e-35
Identities = 101/363 (27%), Positives = 169/363 (46%), Gaps = 20/363 (5%)
Query: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYN 1604
G CS +C IN C C ++ C K L++ + +IR + L+ Y
Sbjct: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING-TGVETVVSADLPNAHGL 1663
++ + N LD D Q+++W+D+ +AI A I+ G + ++ N +
Sbjct: 463 QLVE----QLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
Query: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTDGD 1722
AVDWV + ++WT D K I+VA LDG+ + + L +P + V PL G +YW+D
Sbjct: 519 AVDWVYKTIYWT--DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
Query: 1723 N---ISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778
I A M+G +R L + + P G+ +D +S+LYW+ S H ++ +L+G +
Sbjct: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
Query: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838
+ L AL I D+++W D +E + +K GS L N+ + VY E
Sbjct: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
Query: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETT-----RSCMCTAGYSLRSGQQACEGVGSFL 1893
+Q K + NG C LCLP + +C C +GY++ + C+ + +
Sbjct: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTV 756
Query: 1894 LYS 1896
YS
Sbjct: 757 TYS 759
Score = 147 bits (371), Expect = 2e-34
Identities = 93/268 (34%), Positives = 123/268 (45%), Gaps = 39/268 (14%)
Query: 799 QQQVGTNKCRVNNGGCSS-LCLATPGSRQCAC-AEDQVLD-ADGVTCLANPSYVPPPQCQ 855
++ G C + CSS C+ SR C +D D +D + C PP C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCI----SRNFVCNGQDDCSDGSDELDCA-------PPTCG 194
Query: 856 PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ----HT-CPSDRFKCENNRCIPN 910
EF C+ S CI W CD D DC D SDE+ C + HT CP+ +C + CI
Sbjct: 195 AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHK 254
Query: 911 RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970
+W CDGD DC + DE N C +RTC P+QF C G CI S C+ DC D SDE
Sbjct: 255 KWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Query: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE--------------AGCSHSCS 1016
C +F C +G CI+I+ C+ + DC D SDE GCSH C
Sbjct: 313 KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICK 372
Query: 1017 ST----QFKCNSGRCIPEHWTCDGDNDC 1040
+ C +G + + TC ++C
Sbjct: 373 DLVIGYECDCAAGFELIDRKTCGDIDEC 400
Score = 119 bits (298), Expect = 7e-26
Identities = 91/367 (24%), Positives = 164/367 (44%), Gaps = 41/367 (11%)
Query: 2164 GGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGY---LLYSERTILKSIHLSDERNL 2220
G C Q+C+ G + C C+ G + + G L+++ R ++ I L + +
Sbjct: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
Query: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI--QQINDDGSRRITI 2278
E ++N +AL D A ++F++D+ I I+D R + +
Sbjct: 463 QLV-------EQLRNTVALDADIAA-------QKLFWADLSQKAIFSASIDDKVGRHVKM 508
Query: 2279 VENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFV 2338
++NV + +A + T+YWT + TI+ T+D T+ + S P +
Sbjct: 509 IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIA 562
Query: 2339 LDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2398
+D ++W++W E I +A ++G + L+ DI+ PNG+ +D +LY+ D+ L
Sbjct: 563 VDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKL 621
Query: 2399 DKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLL 2456
+ + +G R ++LKS HP L ++ + ++W D AV ANK GS + L
Sbjct: 622 HMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681
Query: 2457 RVDIPQQPMGII----AVANDTNSCELSPCRINNGGCQDLCLLT-----HQGHVNCSCRG 2507
++ I+ + N CE + NGGC+ LCL H CSC
Sbjct: 682 VNNLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPS 738
Query: 2508 GRILQDD 2514
G ++++
Sbjct: 739 GYNVEEN 745
Score = 73.9 bits (180), Expect = 3e-12
Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-LGTE 83
KTC+ F C + C+ W+CDG+ DC DGSDE+PE C + C+ +E +C +
Sbjct: 70 KTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQC---HMRTCRIHEISCGAHST 125
Query: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
C+P+S C+G DC G DE NC + C P + SS + +
Sbjct: 126 QCIPVSWRCDGENDCDSGEDE--------ENCGNITC---------SPDEFTCSSGRCIS 168
Query: 144 DGKTCKDFDECS 155
C D+CS
Sbjct: 169 RNFVCNGQDDCS 180
Score = 68.6 bits (166), Expect = 1e-10
Identities = 56/180 (31%), Positives = 77/180 (42%), Gaps = 27/180 (15%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
TCSP +F C CIS+ + C+G+ DC DGSDE P C +E C T C
Sbjct: 153 TCSPDEFTCSSG-RCISRNFVCNGQDDCSDGSDELDCAPP-----TCGAHEFQC-STSSC 205
Query: 86 VPMSRLCNGVQDCMDGSDEG-----------PHCRELQGNCSRLGCQHHCVPTLDGPTCY 134
+P+S +C+ DC D SDE C + C C H P C
Sbjct: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
Query: 135 CNSSFQLQADGKTCK-DFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
+ S ++ +TC+ D EC G+C +G I CV+G D +CK N+
Sbjct: 266 -DGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNG--IRDCVDG----SDEVNCKNVNQ 317
Score = 67.0 bits (162), Expect = 4e-10
Identities = 38/104 (36%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
C P QF C + CI+ W+CDG+ DC DGSDE + C ++ C + CV
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-----KNCVKKTCAESDFVCNNGQ-CV 85
Query: 87 PMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---CVP 126
P C+G DC DGSDE P C + C H C+P
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
Score = 33.5 bits (75), Expect = 5.0
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACA 830
D ++ N+C VNNGGCS +C +C CA
Sbjct: 349 DEPLKECHINECLVNNGGCSHICKDLVIGYECDCA 383
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 518 bits (1333), Expect = e-146
Identities = 281/699 (40%), Positives = 374/699 (53%), Gaps = 75/699 (10%)
Query: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCD 2754
C + F C + RCIP W CD++DDC DE C K C+++ F C N CI ++W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2755 GSDDCGDGSDEA-AHCEGKTCGPSSFSC-PGTHVCVPERWLCDGDKDCADGADESIAAGC 2812
G ++C DGSDE+ A C + C SC P +H CVP W CDG+KDC GADE AGC
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
Query: 2813 LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCAN---GR 2869
+ C EF C NR C+ FVCD D DC DGSDE C P CGP EFRC G
Sbjct: 164 A--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGA 220
Query: 2870 CLSSRQWECDGENDCHDQSDEAPK-----NPHCTSQEHKCNASSQFLCSSGRCV------ 2918
C+ R W CD + DC D+SDEA + P TS C +SQF C SG CV
Sbjct: 221 CIPER-WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 2919 ------------AEALL---------------------CNGQDDCGDSSDERGC--HINE 2943
A+ L CN + DC D SDE GC +NE
Sbjct: 280 DGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE 339
Query: 2944 CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSY 3003
CL GCS C DLKIGF+C C GF+L D +TC D+DEC CSQ C+N G +
Sbjct: 340 CLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYF 397
Query: 3004 KCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALD 3063
KC C GY +CKA + P LIF NR+ +R+++L NY+ L L N VALD
Sbjct: 398 KCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 456
Query: 3064 FDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 3121
+ IYW D++ + M + +VL L +P+GLAVDWV ++YW D
Sbjct: 457 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 516
Query: 3122 GRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRS 3181
G TI V+ ++G R L S L EPRA+ VD G++YW+DWGD + I + G++G R
Sbjct: 517 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 576
Query: 3182 VIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD--IPHIFALTL 3239
+V I WPNG+TLD +++R+YW D++ + G NR ++S + H F + +
Sbjct: 577 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 636
Query: 3240 FEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVN-- 3297
FED V+WTD E ++I A++ G ++L L+ P D+ +FH L+QP P+ C+++
Sbjct: 637 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPD-ACELSVQ 695
Query: 3298 -NGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTC 3330
NGGC LCL +P + CACP +LG D + C
Sbjct: 696 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 514 bits (1325), Expect = e-145
Identities = 282/768 (36%), Positives = 394/768 (51%), Gaps = 79/768 (10%)
Query: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
Query: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
Query: 946 GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDN 1005
+C+P SW CD + DC +DE A CA C P +F C N C+ + CD D+DCGD
Sbjct: 139 HKCVPASWRCDGEKDCEGGADE-AGCA-TLCAP-HEFQCGNRSCLAAVFVCDGDDDCGDG 195
Query: 1006 SDEAGCSH-SCSSTQFKC---NSGRCIPEHWTCDGDNDCGDYSDETHANCTNQ---ATRP 1058
SDE GC+ +C +F+C G CIPE W CD DC D SDE C AT
Sbjct: 196 SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
Query: 1059 PGGCHT-DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
P C T +F CR G C+ L WRCDGD DC D SDE C T D +F C D
Sbjct: 256 PAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD---EFQCGDGT- 310
Query: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSD 1177
C+ C+ + DC D SDE C
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGCL------------------------------------ 334
Query: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKC 1237
+ ++C NNGGCSH C+ G C+CP G +L D TC C CSQ C
Sbjct: 335 --QGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQIC 390
Query: 1238 DQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLR 1297
K KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L+P L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
Query: 1298 NTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGN 1357
N +ALD ++ + +YW D+ KIY + EV+I L +PEGLAVDW+ +
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
Query: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
IYW +S I VA +DG R TL + ++ PRAIA+DP G ++W+DW +IE +
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSG 569
Query: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEF 1477
++G R+T+ + WPNG+T+D L +R+ W+D++ + S + G ++ +F
Sbjct: 570 LNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 1478 LSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAP 1537
LSHPF + ++ +V+WTD + AN+ G ++++ P D+ ++H +QP AP
Sbjct: 628 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
Query: 1538 NPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
+ CE + G C +LCL +++ +CACP M L D CY
Sbjct: 688 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
Score = 430 bits (1105), Expect = e-119
Identities = 257/729 (35%), Positives = 355/729 (48%), Gaps = 105/729 (14%)
Query: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3649 TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPP----------- 3697
T C EFQC N C + CDG+DDCGD SDE CA C P
Sbjct: 165 T---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDGGG 219
Query: 3698 ---------NRPFRCKN--------------------------------DRVCLWIGRQC 3716
+R F C++ C+ +G +C
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 3717 DGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
DG +C D +DE DC T C+ EF C + C+ + CN DC DGSDE C
Sbjct: 280 DGDRDCKDKSDEADCPLGT-----CRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Query: 3777 SIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQ 3836
L C N C C + C C +GF + Q C DI+EC CSQ
Sbjct: 334 L--QGLNECLHNNGGCSHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQ 388
Query: 3837 LCNNTKGGHLCSCARNF---MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQA 3893
+C N KG C C + + T N CKA + L + +E+R + Y +
Sbjct: 389 ICVNYKGYFKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRI--DLVKRNYSRL 445
Query: 3894 FQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLN 3953
++V A+DV V R+YW + +SYR + A S+ +++ L
Sbjct: 446 IPMLKNVV--ALDVEVATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LI 492
Query: 3954 ISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRG 4013
L P G+A+DWV ++YWTDSG I VA + G R+TL S + EP AI VDPLRG
Sbjct: 493 DEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG 552
Query: 4014 TMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 4073
MYWSDWG+ KIE + ++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI
Sbjct: 553 FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Query: 4074 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHA 4133
+G + S LSHPF I VFED ++ N +F ++ + L L++
Sbjct: 613 FSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNP 672
Query: 4134 SDVVLYHQHKQPEVTNPCD-----RKKCEWLCLLSPS----GP--VCTCPNGKRL--DNG 4180
D+V++H+ KQP + C+ CE+LCL +P P C CP+ L D
Sbjct: 673 HDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK 732
Query: 4181 TCVPVPSPT 4189
C P T
Sbjct: 733 RCYRAPQST 741
Score = 259 bits (662), Expect = 4e-68
Identities = 131/312 (41%), Positives = 166/312 (53%), Gaps = 21/312 (6%)
Query: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
+RC+G+ +C G DE C + CAP++FQC + C+ V+VCD D+DC DGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATL-CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDE-RGC 201
Query: 3490 TQMTCGVDEFRC--KDSGRCIPARWKCDGEDDCGDGSDEPKEECDE----RTCEP----- 3538
CG EFRC G CIP RW CD + DC D SDE E C T P
Sbjct: 202 ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACAT 261
Query: 3539 -YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGD 3597
QF C++ CV W+CD D DC D SDE C C EF C +G C+ C+ +
Sbjct: 262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE 321
Query: 3598 HDCADGSDEKDC 3609
DC DGSDE C
Sbjct: 322 QDCPDGSDEAGC 333
Score = 257 bits (657), Expect = 2e-67
Identities = 171/509 (33%), Positives = 247/509 (48%), Gaps = 35/509 (6%)
Query: 20 AIDAPKTCSP-KQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHN 78
A AP C+ QFACR C+ GWRCDG+RDC D SDEA CP C+ +E
Sbjct: 252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEAD--CPLGT---CRGDEFQ 305
Query: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTCYCN 136
C G CV + CN QDC DGSDE C + C + GC H C G C C
Sbjct: 306 C-GDGTCVLAIKHCNQEQDCPDGSDEAG-CLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Query: 137 SSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
+ FQL D KTC D DEC CSQ+C N G F C C GY + ++CKA
Sbjct: 364 AGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AG 419
Query: 197 RPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQL 256
+ P L+ N + L S + P + A+D A + W + + ++
Sbjct: 420 KSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SYRKI 474
Query: 257 KCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVT 316
A M E + I LH E +A+DW+ + Y+ D + I V +G T
Sbjct: 475 YSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRT 533
Query: 317 LLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDL 376
L L P+ IA+DP G ++++D+G K+E+ ++G +R LV I +P+GITLDL
Sbjct: 534 LFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDL 593
Query: 377 VSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQ 435
+S+ +YW D+ L + +D+ G R+T+I + H +G+ VFE+ ++ T+ +N
Sbjct: 594 LSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN----- 648
Query: 436 KTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494
++ NR N E ++ ++ + I+H+ +QPR ACE GGC +CL
Sbjct: 649 -EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCL 705
Query: 495 LA---NSHKAR-TCRCRSGFSLGSDGKSC 519
A +SH + TC C LG D K C
Sbjct: 706 PAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 180 bits (457), Expect = 3e-44
Identities = 111/307 (36%), Positives = 139/307 (45%), Gaps = 41/307 (13%)
Query: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Query: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFA 2702
F+ G + C A +VCDG +DCGD SDER C P C F
Sbjct: 167 CAPHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCAD---PACGPREFR 212
Query: 2703 C---PSGRCIPMSWTCDKEDDCEHGEDE------------THCNKFCSEA-QFECQNHRC 2746
C G CIP W CD++ DCE DE T C+ A QF C++ C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 2747 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
+ W CDG DC D SDE A C TC F C G CV C+ ++DC DG+DE
Sbjct: 273 VHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 2807 SIAAGCL 2813
AGCL
Sbjct: 331 ---AGCL 334
Score = 171 bits (434), Expect = 1e-41
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 443
Query: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
Query: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 678 FHELKQPRAPDACELSVQPNGGCEYLCL 705
Score = 167 bits (422), Expect = 3e-40
Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 378 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 434
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 435 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 491
Query: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 548
Query: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 549 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 601
Query: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 659
Query: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 660 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
Query: 827 CACAEDQVLDADGVTCLANP 846
CAC + L D C P
Sbjct: 719 CACPDTMWLGPDMKRCYRAP 738
Score = 151 bits (381), Expect = 2e-35
Identities = 93/276 (33%), Positives = 123/276 (44%), Gaps = 25/276 (9%)
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC--SNGRCVSNML 2583
A +F C NG CI+ CDG C D SDE + C + C C ++ +CV
Sbjct: 87 ADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW 146
Query: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATD 2643
C+G DC G+DE C T C EF+C + +C+ C+ DC D SDE C+
Sbjct: 147 RCDGEKDCEGGADEAGC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA 205
Query: 2644 CS-SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE------RDCPGVKRPR- 2695
C FR G G C WVCD DC D SDE R PG
Sbjct: 206 CGPREFRCGGDG--------GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPA 257
Query: 2696 --CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL 2752
+ FAC SG C+ + W CD + DC+ DE C C +F+C + C+
Sbjct: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKH 317
Query: 2753 CDGSDDCGDGSDEAAHCEG-KTCGPSSFSCPGTHVC 2787
C+ DC DGSDEA +G C ++ C +H+C
Sbjct: 318 CNQEQDCPDGSDEAGCLQGLNECLHNNGGC--SHIC 351
Score = 149 bits (377), Expect = 5e-35
Identities = 123/366 (33%), Positives = 154/366 (42%), Gaps = 67/366 (18%)
Query: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGH------KCACPTNFYLGSDGR--TCVSN-CTA 3336
+ D P C ++ C N GH KC GSD TC C A
Sbjct: 78 EDDCPKKTCADSDFTCDN--------GHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 129
Query: 3337 SQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICD 3394
+ C + KC+P W+CD E DC +DE C C P +FQC C F+CD
Sbjct: 130 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEA-GCATL-CAPHEFQCGNRSCLAAVFVCD 187
Query: 3395 GDNDCQDNSDEANCDIHVCLPSQFKC--TNTNRCIPGIFRCNGQDNCGDGEDE------R 3446
GD+DC D SDE C C P +F+C CIP + C+ Q +C D DE R
Sbjct: 188 GDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGR 247
Query: 3447 DCPEVTCAP------NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
P T AP +QF C + C+ W CD D DC D SDE A+C TC DEF+
Sbjct: 248 PGPGATSAPAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQ 305
Query: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEP-----KEEC------DERTCEPYQ--FRCKNNR 3547
C D G C+ A C+ E DC DGSDE EC C + F C
Sbjct: 306 CGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC---- 360
Query: 3548 CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEK 3607
P +Q CGD +E P CS+ C N + G +KC +C G +
Sbjct: 361 TCPAGFQLLDQKTCGD--IDECKDPDACSQ---ICVNYK---GYFKC----ECYPGYEMD 408
Query: 3608 DCTPRC 3613
T C
Sbjct: 409 LLTKNC 414
Score = 139 bits (349), Expect = 8e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
Query: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 445 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
Query: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 501 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
Query: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
Query: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
Query: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 679 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 721
Score = 129 bits (324), Expect = 7e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 386 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 443
Query: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 444 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 544
Query: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 545 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 663
Query: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 664 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 720
Query: 2505 C 2505
C
Sbjct: 721 C 721
Score = 79.7 bits (195), Expect = 6e-14
Identities = 57/176 (32%), Positives = 68/176 (38%), Gaps = 22/176 (12%)
Query: 2485 NNGGCQDLCLLTHQ---GHVNCS-----CRGGRILQDDLTCRAVNSSCRAQDEFECAN-- 2534
+ GC LC H+ G+ +C C G D R EF C
Sbjct: 159 DEAGCATLCA-PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
Query: 2535 -GECINFSLTCDGVPHCKDKSDEKPSYCNS---------RRCKKTFR-QCSNGRCVSNML 2583
G CI CD C+D+SDE C C + C +G CV
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
C+G DC D SDE C C EF+C DGTC+ CNQ DC D SDE C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 75.1 bits (183), Expect = 1e-12
Identities = 42/108 (38%), Positives = 53/108 (49%), Gaps = 17/108 (15%)
Query: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA-----PEICPQSKAQRCQPN 75
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
Query: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCSRLGC 120
H CVP S C+G +DC G+DE C + C C
Sbjct: 138 SHK------CVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSC 179
Score = 71.6 bits (174), Expect = 2e-11
Identities = 64/196 (32%), Positives = 84/196 (42%), Gaps = 44/196 (22%)
Query: 6 LLLLLPLLSALVAAAIDA-------PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSD 58
LLLLL L L AAA D K C QF CR++ CI WRCD + DC D SD
Sbjct: 19 LLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSD 77
Query: 59 EAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSR 117
E + CP+ + C ++ C C+ C+G ++C DGSDE C + +
Sbjct: 78 E--DDCPK---KTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Query: 118 LGC---QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
L C H CVP + DG+ KD + + C+ LC + F CG
Sbjct: 132 LSCGPTSHKCVPA------------SWRCDGE--KDCEGGADEAGCATLCAPHE--FQCG 175
Query: 175 CVEGYLLQPDNRSCKA 190
NRSC A
Sbjct: 176 ----------NRSCLA 181
Score = 40.0 bits (92), Expect = 0.053
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 13/119 (10%)
Query: 4290 PQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS---- 4345
P P Q+ SG C + G DG R C+ + + + C + C
Sbjct: 250 PGATSAPAACATASQFACRSGECVHLG---WRCDGDRDCKDKS--DEADCPLGTCRGDEF 304
Query: 4346 RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHC-SNGGSCT---MNSKMMPECQCP 4400
+C +G CV+ + + +C DG CL + C N G C+ + K+ EC CP
Sbjct: 305 QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Score = 35.8 bits (81), Expect = 1.00
Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538
L+ C NNGGC +C G C+C G L D TC ++ C+ D + C+
Sbjct: 337 LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 391
Query: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565
N+ C+ P +CK + + PS + R
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 429
Score = 33.1 bits (74), Expect = 6.5
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
G N+C NNGGCS +C +C C A Q+LD
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 518 bits (1333), Expect = e-146
Identities = 281/699 (40%), Positives = 374/699 (53%), Gaps = 75/699 (10%)
Query: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCD 2754
C + F C + RCIP W CD++DDC DE C K C+++ F C N CI ++W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2755 GSDDCGDGSDEA-AHCEGKTCGPSSFSC-PGTHVCVPERWLCDGDKDCADGADESIAAGC 2812
G ++C DGSDE+ A C + C SC P +H CVP W CDG+KDC GADE AGC
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
Query: 2813 LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCAN---GR 2869
+ C EF C NR C+ FVCD D DC DGSDE C P CGP EFRC G
Sbjct: 164 A--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGA 220
Query: 2870 CLSSRQWECDGENDCHDQSDEAPK-----NPHCTSQEHKCNASSQFLCSSGRCV------ 2918
C+ R W CD + DC D+SDEA + P TS C +SQF C SG CV
Sbjct: 221 CIPER-WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 2919 ------------AEALL---------------------CNGQDDCGDSSDERGC--HINE 2943
A+ L CN + DC D SDE GC +NE
Sbjct: 280 DGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE 339
Query: 2944 CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSY 3003
CL GCS C DLKIGF+C C GF+L D +TC D+DEC CSQ C+N G +
Sbjct: 340 CLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYF 397
Query: 3004 KCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALD 3063
KC C GY +CKA + P LIF NR+ +R+++L NY+ L L N VALD
Sbjct: 398 KCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 456
Query: 3064 FDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDK 3121
+ IYW D++ + M + +VL L +P+GLAVDWV ++YW D
Sbjct: 457 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 516
Query: 3122 GRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRS 3181
G TI V+ ++G R L S L EPRA+ VD G++YW+DWGD + I + G++G R
Sbjct: 517 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 576
Query: 3182 VIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD--IPHIFALTL 3239
+V I WPNG+TLD +++R+YW D++ + G NR ++S + H F + +
Sbjct: 577 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 636
Query: 3240 FEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVN-- 3297
FED V+WTD E ++I A++ G ++L L+ P D+ +FH L+QP P+ C+++
Sbjct: 637 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPD-ACELSVQ 695
Query: 3298 -NGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTC 3330
NGGC LCL +P + CACP +LG D + C
Sbjct: 696 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 514 bits (1325), Expect = e-145
Identities = 282/768 (36%), Positives = 394/768 (51%), Gaps = 79/768 (10%)
Query: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
Query: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
Query: 946 GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDN 1005
+C+P SW CD + DC +DE A CA C P +F C N C+ + CD D+DCGD
Sbjct: 139 HKCVPASWRCDGEKDCEGGADE-AGCA-TLCAP-HEFQCGNRSCLAAVFVCDGDDDCGDG 195
Query: 1006 SDEAGCSH-SCSSTQFKC---NSGRCIPEHWTCDGDNDCGDYSDETHANCTNQ---ATRP 1058
SDE GC+ +C +F+C G CIPE W CD DC D SDE C AT
Sbjct: 196 SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
Query: 1059 PGGCHT-DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
P C T +F CR G C+ L WRCDGD DC D SDE C T D +F C D
Sbjct: 256 PAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD---EFQCGDGT- 310
Query: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSD 1177
C+ C+ + DC D SDE C
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGCL------------------------------------ 334
Query: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKC 1237
+ ++C NNGGCSH C+ G C+CP G +L D TC C CSQ C
Sbjct: 335 --QGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQIC 390
Query: 1238 DQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLR 1297
K KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L+P L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
Query: 1298 NTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGN 1357
N +ALD ++ + +YW D+ KIY + EV+I L +PEGLAVDW+ +
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
Query: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
IYW +S I VA +DG R TL + ++ PRAIA+DP G ++W+DW +IE +
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSG 569
Query: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEF 1477
++G R+T+ + WPNG+T+D L +R+ W+D++ + S + G ++ +F
Sbjct: 570 LNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
Query: 1478 LSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAP 1537
LSHPF + ++ +V+WTD + AN+ G ++++ P D+ ++H +QP AP
Sbjct: 628 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
Query: 1538 NPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
+ CE + G C +LCL +++ +CACP M L D CY
Sbjct: 688 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
Score = 430 bits (1105), Expect = e-119
Identities = 257/729 (35%), Positives = 355/729 (48%), Gaps = 105/729 (14%)
Query: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3649 TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPP----------- 3697
T C EFQC N C + CDG+DDCGD SDE CA C P
Sbjct: 165 T---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG--CADPACGPREFRCGGDGGG 219
Query: 3698 ---------NRPFRCKN--------------------------------DRVCLWIGRQC 3716
+R F C++ C+ +G +C
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
Query: 3717 DGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
DG +C D +DE DC T C+ EF C + C+ + CN DC DGSDE C
Sbjct: 280 DGDRDCKDKSDEADCPLGT-----CRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Query: 3777 SIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQ 3836
L C N C C + C C +GF + Q C DI+EC CSQ
Sbjct: 334 L--QGLNECLHNNGGCSHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQ 388
Query: 3837 LCNNTKGGHLCSCARNF---MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQA 3893
+C N KG C C + + T N CKA + L + +E+R + Y +
Sbjct: 389 ICVNYKGYFKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRI--DLVKRNYSRL 445
Query: 3894 FQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLN 3953
++V A+DV V R+YW + +SYR + A S+ +++ L
Sbjct: 446 IPMLKNVV--ALDVEVATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LI 492
Query: 3954 ISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRG 4013
L P G+A+DWV ++YWTDSG I VA + G R+TL S + EP AI VDPLRG
Sbjct: 493 DEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG 552
Query: 4014 TMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIR 4073
MYWSDWG+ KIE + ++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI
Sbjct: 553 FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
Query: 4074 LNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHA 4133
+G + S LSHPF I VFED ++ N +F ++ + L L++
Sbjct: 613 FSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNP 672
Query: 4134 SDVVLYHQHKQPEVTNPCD-----RKKCEWLCLLSPS----GP--VCTCPNGKRL--DNG 4180
D+V++H+ KQP + C+ CE+LCL +P P C CP+ L D
Sbjct: 673 HDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK 732
Query: 4181 TCVPVPSPT 4189
C P T
Sbjct: 733 RCYRAPQST 741
Score = 259 bits (662), Expect = 4e-68
Identities = 131/312 (41%), Positives = 166/312 (53%), Gaps = 21/312 (6%)
Query: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
+RC+G+ +C G DE C + CAP++FQC + C+ V+VCD D+DC DGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATL-CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDE-RGC 201
Query: 3490 TQMTCGVDEFRC--KDSGRCIPARWKCDGEDDCGDGSDEPKEECDE----RTCEP----- 3538
CG EFRC G CIP RW CD + DC D SDE E C T P
Sbjct: 202 ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACAT 261
Query: 3539 -YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGD 3597
QF C++ CV W+CD D DC D SDE C C EF C +G C+ C+ +
Sbjct: 262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE 321
Query: 3598 HDCADGSDEKDC 3609
DC DGSDE C
Sbjct: 322 QDCPDGSDEAGC 333
Score = 257 bits (657), Expect = 2e-67
Identities = 171/509 (33%), Positives = 247/509 (48%), Gaps = 35/509 (6%)
Query: 20 AIDAPKTCSP-KQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHN 78
A AP C+ QFACR C+ GWRCDG+RDC D SDEA CP C+ +E
Sbjct: 252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEAD--CPLGT---CRGDEFQ 305
Query: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTCYCN 136
C G CV + CN QDC DGSDE C + C + GC H C G C C
Sbjct: 306 C-GDGTCVLAIKHCNQEQDCPDGSDEAG-CLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Query: 137 SSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
+ FQL D KTC D DEC CSQ+C N G F C C GY + ++CKA
Sbjct: 364 AGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AG 419
Query: 197 RPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQL 256
+ P L+ N + L S + P + A+D A + W + + ++
Sbjct: 420 KSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SYRKI 474
Query: 257 KCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVT 316
A M E + I LH E +A+DW+ + Y+ D + I V +G T
Sbjct: 475 YSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRT 533
Query: 317 LLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDL 376
L L P+ IA+DP G ++++D+G K+E+ ++G +R LV I +P+GITLDL
Sbjct: 534 LFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDL 593
Query: 377 VSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQ 435
+S+ +YW D+ L + +D+ G R+T+I + H +G+ VFE+ ++ T+ +N
Sbjct: 594 LSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN----- 648
Query: 436 KTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494
++ NR N E ++ ++ + I+H+ +QPR ACE GGC +CL
Sbjct: 649 -EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCL 705
Query: 495 LA---NSHKAR-TCRCRSGFSLGSDGKSC 519
A +SH + TC C LG D K C
Sbjct: 706 PAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 180 bits (457), Expect = 3e-44
Identities = 111/307 (36%), Positives = 139/307 (45%), Gaps = 41/307 (13%)
Query: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Query: 2643 DCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFA 2702
F+ G + C A +VCDG +DCGD SDER C P C F
Sbjct: 167 CAPHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCAD---PACGPREFR 212
Query: 2703 C---PSGRCIPMSWTCDKEDDCEHGEDE------------THCNKFCSEA-QFECQNHRC 2746
C G CIP W CD++ DCE DE T C+ A QF C++ C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 2747 ISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
+ W CDG DC D SDE A C TC F C G CV C+ ++DC DG+DE
Sbjct: 273 VHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 2807 SIAAGCL 2813
AGCL
Sbjct: 331 ---AGCL 334
Score = 171 bits (434), Expect = 1e-41
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 443
Query: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
Query: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 678 FHELKQPRAPDACELSVQPNGGCEYLCL 705
Score = 167 bits (422), Expect = 3e-40
Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 378 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 434
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 435 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 491
Query: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 492 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 548
Query: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 549 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 601
Query: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 659
Query: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 660 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
Query: 827 CACAEDQVLDADGVTCLANP 846
CAC + L D C P
Sbjct: 719 CACPDTMWLGPDMKRCYRAP 738
Score = 151 bits (381), Expect = 2e-35
Identities = 93/276 (33%), Positives = 123/276 (44%), Gaps = 25/276 (9%)
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC--SNGRCVSNML 2583
A +F C NG CI+ CDG C D SDE + C + C C ++ +CV
Sbjct: 87 ADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW 146
Query: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATD 2643
C+G DC G+DE C T C EF+C + +C+ C+ DC D SDE C+
Sbjct: 147 RCDGEKDCEGGADEAGC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA 205
Query: 2644 CS-SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE------RDCPGVKRPR- 2695
C FR G G C WVCD DC D SDE R PG
Sbjct: 206 CGPREFRCGGDG--------GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPA 257
Query: 2696 --CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL 2752
+ FAC SG C+ + W CD + DC+ DE C C +F+C + C+
Sbjct: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKH 317
Query: 2753 CDGSDDCGDGSDEAAHCEG-KTCGPSSFSCPGTHVC 2787
C+ DC DGSDEA +G C ++ C +H+C
Sbjct: 318 CNQEQDCPDGSDEAGCLQGLNECLHNNGGC--SHIC 351
Score = 149 bits (377), Expect = 5e-35
Identities = 123/366 (33%), Positives = 154/366 (42%), Gaps = 67/366 (18%)
Query: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGH------KCACPTNFYLGSDGR--TCVSN-CTA 3336
+ D P C ++ C N GH KC GSD TC C A
Sbjct: 78 EDDCPKKTCADSDFTCDN--------GHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 129
Query: 3337 SQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICD 3394
+ C + KC+P W+CD E DC +DE C C P +FQC C F+CD
Sbjct: 130 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEA-GCATL-CAPHEFQCGNRSCLAAVFVCD 187
Query: 3395 GDNDCQDNSDEANCDIHVCLPSQFKC--TNTNRCIPGIFRCNGQDNCGDGEDE------R 3446
GD+DC D SDE C C P +F+C CIP + C+ Q +C D DE R
Sbjct: 188 GDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGR 247
Query: 3447 DCPEVTCAP------NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
P T AP +QF C + C+ W CD D DC D SDE A+C TC DEF+
Sbjct: 248 PGPGATSAPAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQ 305
Query: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEP-----KEEC------DERTCEPYQ--FRCKNNR 3547
C D G C+ A C+ E DC DGSDE EC C + F C
Sbjct: 306 CGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC---- 360
Query: 3548 CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEK 3607
P +Q CGD +E P CS+ C N + G +KC +C G +
Sbjct: 361 TCPAGFQLLDQKTCGD--IDECKDPDACSQ---ICVNYK---GYFKC----ECYPGYEMD 408
Query: 3608 DCTPRC 3613
T C
Sbjct: 409 LLTKNC 414
Score = 139 bits (349), Expect = 8e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
Query: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 445 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
Query: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 501 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
Query: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
Query: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
Query: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 679 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 721
Score = 129 bits (324), Expect = 7e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 386 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 443
Query: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 444 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 544
Query: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 545 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 663
Query: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 664 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 720
Query: 2505 C 2505
C
Sbjct: 721 C 721
Score = 79.7 bits (195), Expect = 6e-14
Identities = 57/176 (32%), Positives = 68/176 (38%), Gaps = 22/176 (12%)
Query: 2485 NNGGCQDLCLLTHQ---GHVNCS-----CRGGRILQDDLTCRAVNSSCRAQDEFECAN-- 2534
+ GC LC H+ G+ +C C G D R EF C
Sbjct: 159 DEAGCATLCA-PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
Query: 2535 -GECINFSLTCDGVPHCKDKSDEKPSYCNS---------RRCKKTFR-QCSNGRCVSNML 2583
G CI CD C+D+SDE C C + C +G CV
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
Query: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
C+G DC D SDE C C EF+C DGTC+ CNQ DC D SDE C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 75.1 bits (183), Expect = 1e-12
Identities = 42/108 (38%), Positives = 53/108 (49%), Gaps = 17/108 (15%)
Query: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA-----PEICPQSKAQRCQPN 75
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
Query: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDE---GPHCRELQGNCSRLGC 120
H CVP S C+G +DC G+DE C + C C
Sbjct: 138 SHK------CVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSC 179
Score = 71.6 bits (174), Expect = 2e-11
Identities = 64/196 (32%), Positives = 84/196 (42%), Gaps = 44/196 (22%)
Query: 6 LLLLLPLLSALVAAAIDA-------PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSD 58
LLLLL L L AAA D K C QF CR++ CI WRCD + DC D SD
Sbjct: 19 LLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSD 77
Query: 59 EAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSR 117
E + CP+ + C ++ C C+ C+G ++C DGSDE C + +
Sbjct: 78 E--DDCPK---KTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
Query: 118 LGC---QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
L C H CVP + DG+ KD + + C+ LC + F CG
Sbjct: 132 LSCGPTSHKCVPA------------SWRCDGE--KDCEGGADEAGCATLCAPHE--FQCG 175
Query: 175 CVEGYLLQPDNRSCKA 190
NRSC A
Sbjct: 176 ----------NRSCLA 181
Score = 40.0 bits (92), Expect = 0.053
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 13/119 (10%)
Query: 4290 PQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS---- 4345
P P Q+ SG C + G DG R C+ + + + C + C
Sbjct: 250 PGATSAPAACATASQFACRSGECVHLG---WRCDGDRDCKDKS--DEADCPLGTCRGDEF 304
Query: 4346 RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHC-SNGGSCT---MNSKMMPECQCP 4400
+C +G CV+ + + +C DG CL + C N G C+ + K+ EC CP
Sbjct: 305 QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Score = 35.8 bits (81), Expect = 1.00
Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538
L+ C NNGGC +C G C+C G L D TC ++ C+ D + C+
Sbjct: 337 LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 391
Query: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565
N+ C+ P +CK + + PS + R
Sbjct: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 429
Score = 33.1 bits (74), Expect = 6.5
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
G N+C NNGGCS +C +C C A Q+LD
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 503 bits (1295), Expect = e-141
Identities = 285/711 (40%), Positives = 384/711 (54%), Gaps = 52/711 (7%)
Query: 2660 CERTSL------CYAPSWVCDGANDCGDYSDERD--CPGVKRPRCPLNYFACPS--GRCI 2709
CER C + WVCDG+ +C D SDE C V C F+C RCI
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT---CKSGDFSCGGRVNRCI 83
Query: 2710 PMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAH 2768
P W CD + DC++G DE C K CS+ +F C + +CIS+Q++CD DC DGSDEA+
Sbjct: 84 PQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS- 142
Query: 2769 CEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLY-----NSTCDDRE 2822
C TCGP+SF C + C+P+ W CD D DC DG+DE LY +S C E
Sbjct: 143 CPVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFE 201
Query: 2823 FMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGEN 2882
F C + +CI + CD DC D SDE C TC P EF+C++G C+ + +CD E
Sbjct: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEE-NCAVATCRPDEFQCSDGNCIHGSR-QCDREY 259
Query: 2883 DCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE--RGCH 2940
DC D SDE C + C ++F C SG C+ +CN DC D SDE + C
Sbjct: 260 DCKDMSDEVG----CVNVT-LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECG 314
Query: 2941 INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH 3000
NECL GCS C DLKIG++C C GF+L R C D+DEC CSQ C+N
Sbjct: 315 TNECLDNN-GGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLE 372
Query: 3001 GSYKCLCVEGYAPRGGDPHS--CKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNN 3058
G YKC C EG+ DPH+ CKAV +L F NR+ +RK+ LD S YT L L N
Sbjct: 373 GGYKCQCEEGFQL---DPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRN 428
Query: 3059 AVALDFDYREQMIYWTDVTTQ---GSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGN 3115
VALD + IYW+D++ + + + R H S V+ R + PDGLAVDW+ N
Sbjct: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD-IQAPDGLAVDWIHSN 487
Query: 3116 LYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGM 3175
+YW D T+ V+ G R L +PRA+VVD +G++YWTDWG + I + G+
Sbjct: 488 IYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGL 547
Query: 3176 DGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD--IPH 3233
+G +V I WPNG+TLD ++ R+YW D++ I ++G NR +L + + H
Sbjct: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 3234 IFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPN-- 3291
F+L +FED V+WTD ++I A++ TG++ LL L P D+ +FH L QP N
Sbjct: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWC 667
Query: 3292 HPCKVNNGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTCVSNCTAS 3337
++NGGC LCL +P CACP L D R+C++ A+
Sbjct: 668 ERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
Score = 475 bits (1223), Expect = e-133
Identities = 277/748 (37%), Positives = 381/748 (50%), Gaps = 84/748 (11%)
Query: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCEN--NRCIPN 910
+C+ EF C + +CI +W CDG +C D SDE+ C TC S F C NRCIP
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 911 RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970
W CDG DC N DE C +TC ++F C G+CI + CD D DC D SDE AS
Sbjct: 86 FWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE-AS 142
Query: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE-----------AGCSHSCSSTQ 1019
C TC P F CN+ CI W CDND DC D SDE G S CS+ +
Sbjct: 143 CPVLTCGP-ASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFE 201
Query: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
F C SG CI W CDG DC D SDE NC RP DEFQC DG CI
Sbjct: 202 FHCLSGECIHSSWRCDGGPDCKDKSDE--ENCAVATCRP------DEFQCS-DGNCIHGS 252
Query: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
+CD + DC D SDE C VT +C+ KF C S CI+ VC+ DC D SDE
Sbjct: 253 RQCDREYDCKDMSDEVGCVNVT-LCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDE-- 308
Query: 1140 CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVA 1199
P K C G ++C D NNGGCSH C+
Sbjct: 309 ----------------------PIKEC-GTNECLD-------------NNGGCSHVCNDL 332
Query: 1200 PGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGE 1259
G C CP G +L C+ C CSQ C + KC C EG+ L+P +
Sbjct: 333 K-IGYECLCPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTK 390
Query: 1260 SCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVED 1319
+C+++ ++ F+NRHE+R++ L + +Y+ L+P LRN +ALD ++ + +YW+D+ +
Sbjct: 391 ACKAVGSI-AYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR 449
Query: 1320 KIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRT 1379
I +L ++S++ VI + P+GLAVDWI NIYW +S L + VA G R
Sbjct: 450 MICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRK 509
Query: 1380 TLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGL 1439
TL + PRAI +DP G ++WTDW + +I+ ++G ++ E WPNG+
Sbjct: 510 TLFRENGSKPRAIVVDPVHGFMYWTDW-GTPAKIKKGGLNGVDIYSLVTENIQ--WPNGI 566
Query: 1440 TVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTN 1499
T+D L R+ W+D++ +I S +G +L + L+HPF++ ++ +V+WTD
Sbjct: 567 TLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINE 626
Query: 1500 TLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCE----ANGGQGPCSHLCL- 1554
+ AN+ TG +V ++ P D+ ++H QP N CE +NGG C +LCL
Sbjct: 627 AIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGG---CQYLCLP 683
Query: 1555 ---IN-YNRTVSCACPHLMKLHKDNTTC 1578
IN ++ +CACP M L +D +C
Sbjct: 684 APQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 461 bits (1187), Expect = e-129
Identities = 270/711 (37%), Positives = 371/711 (52%), Gaps = 60/711 (8%)
Query: 3494 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPG 3551
C +EF+C+D G+CI +W CDG +C DGSDE +E C TC+ F C + NRC+P
Sbjct: 27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 3552 RWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP 3611
W+CD DC + SDE+ C P+ CS+ EF C +G+CI+ ++ CD D DC DGSDE C
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
Query: 3612 -RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDE--EAC-GTGV-----RTCPLDEFQCN 3662
C FQC S CIP W CD D DC DGSDE + C G V C EF C
Sbjct: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL 205
Query: 3663 NTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNC 3722
+ C +W+CDG DC D SDE E CA C P+ F+C +D C+ RQCD +C
Sbjct: 206 SGECIHSSWRCDGGPDCKDKSDE--ENCAVATCRPDE-FQC-SDGNCIHGSRQCDREYDC 261
Query: 3723 GDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDP 3780
D +DE C + T C+ +F C + C++ CNM DC D SDE ++C +
Sbjct: 262 KDMSDEVGC----VNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNE 317
Query: 3781 KLTSCATNASICGDEARCVRTEKAAY-CACRSGFHTVPGQPGCQDINECLRFGTCSQLCN 3839
L + + +C D K Y C C GF V Q C+DI+EC TCSQLC
Sbjct: 318 CLDNNGGCSHVCNDL-------KIGYECLCPDGFQLV-AQRRCEDIDECQDPDTCSQLCV 369
Query: 3840 NTKGGHLCSCARNFMKTHNT--CKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGD 3897
N +GG+ C C F +T CKA GS L+ + +E+R + S Y
Sbjct: 370 NLEGGYKCQCEEGFQLDPHTKACKAVGS-IAYLFFTNRHEVRKMTLDR--SEYTSLIPNL 426
Query: 3898 ESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGL 3957
+V A+D V + R+YW++ I L A ++ + I R +
Sbjct: 427 RNVV--ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSS---YDTVISRDI-------- 473
Query: 3958 KMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYW 4017
+ P G+A+DW+ N+YWTDS + VA KG RKTL +P AIVVDP+ G MYW
Sbjct: 474 QAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYW 533
Query: 4018 SDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGT 4077
+DWG KI+ ++G +LV +NIQWP G+ +D + RLYW D+KL I SI +NG
Sbjct: 534 TDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGG 593
Query: 4078 DPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVV 4137
+ + ++ L+HPFS+ VFED ++ IN +F ++ S + L L D+V
Sbjct: 594 NRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMV 653
Query: 4138 LYHQHKQPEVTNPCDRKK-----CEWLCL----LSPSGP--VCTCPNGKRL 4177
L+H QP N C+R C++LCL ++P P C CP+G L
Sbjct: 654 LFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLL 704
Score = 259 bits (662), Expect = 4e-68
Identities = 135/362 (37%), Positives = 188/362 (51%), Gaps = 39/362 (10%)
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEA--NCDIHVCLPSQFKC-TNTNRCIPG 3429
+C +FQC G C + ++CDG +CQD SDE+ C C F C NRCIP
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
+RC+GQ +C +G DE+ CP TC+ ++F+C K CI R +VCD D DC+DGSDE A+C
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK-CISRQFVCDSDRDCLDGSDE-ASC 143
Query: 3490 TQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC--------DERTCEPYQF 3541
+TCG F+C +S CIP W CD + DC DGSDE + C D C ++F
Sbjct: 144 PVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
Query: 3542 RCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCA 3601
C + C+ W+CD DC D SDEE+C C EF C++G CI G +CD ++DC
Sbjct: 203 HCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCK 262
Query: 3602 DGSDEKDC--TPRCD-MDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDE 3658
D SDE C C+ ++F+C SG CI L C+ DC D SDE G C +
Sbjct: 263 DMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNN 322
Query: 3659 FQCNNTLCKPL----------------AWKCDGEDDCGDNSDENPEECARFVCPPNRPFR 3702
C++ +C L +C+ D+C D P+ C++ ++
Sbjct: 323 GGCSH-VCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD-----PDTCSQLCVNLEGGYK 376
Query: 3703 CK 3704
C+
Sbjct: 377 CQ 378
Score = 229 bits (583), Expect = 6e-59
Identities = 128/361 (35%), Positives = 170/361 (47%), Gaps = 37/361 (10%)
Query: 3312 GHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPD-CP 3370
G K L + G C ++F C++ KCI + W CD +C D SDE + C
Sbjct: 5 GWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCL 64
Query: 3371 EFKCRPGQFQCSTGI--CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIP 3428
C+ G F C + C + CDG DC + SDE C C +F+C + +CI
Sbjct: 65 SVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRC-HDGKCIS 123
Query: 3429 GIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE-PA 3487
F C+ +C DG DE CP +TC P FQC+ + CIP++W CD D DC DGSDE P
Sbjct: 124 RQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN-SSTCIPQLWACDNDPDCEDGSDEWPQ 182
Query: 3488 NCTQM--------TCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPY 3539
C + C EF C SG CI + W+CDG DC D SDE E C TC P
Sbjct: 183 RCRGLYVFQGDSSPCSAFEFHCL-SGECIHSSWRCDGGPDCKDKSDE--ENCAVATCRPD 239
Query: 3540 QFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSE--SEFSCANGRCIAGRWKCDGD 3597
+F+C + C+ G QCD + DC D SDE C E ++F C +G CI C+
Sbjct: 240 EFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMA 299
Query: 3598 HDCADGSDE--KDCTPRCDMD----------------QFQCKSGHCIPLRWRCDADADCM 3639
DC D SDE K+C +D + C G + + RC+ +C
Sbjct: 300 RDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ 359
Query: 3640 D 3640
D
Sbjct: 360 D 360
Score = 224 bits (570), Expect = 2e-57
Identities = 153/505 (30%), Positives = 236/505 (46%), Gaps = 33/505 (6%)
Query: 23 APKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQ-PNEHNCLG 81
A TC P +F C D CI +CD E DC D SDE + C+ PN+ C
Sbjct: 232 AVATCRPDEFQCSDG-NCIHGSRQCDREYDCKDMSDEVGCV----NVTLCEGPNKFKCHS 286
Query: 82 TELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
E C+ + ++CN +DC D SDE C + + GC H C G C C FQ
Sbjct: 287 GE-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ 345
Query: 141 LQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV 200
L A + C+D DEC TCSQLC N +G + C C EG+ L P ++CKA V
Sbjct: 346 LVAQ-RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKA----VGSIAY 400
Query: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR 260
L N + L ++ +++ P + R A+D A+ + W S ++ C+
Sbjct: 401 LFFTNRHEVRKMTLDRSEYTSLIP-NLRNVVALDTEVASNRIYW-----SDLSQRMICST 454
Query: 261 MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDL 320
V + IS + + +A+DW+ N Y+ D + + V + G TL
Sbjct: 455 QLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE 514
Query: 321 ELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRL 380
P+ I +DP G +++TD+G K+++ ++G + LV I +P+GITLDL+S
Sbjct: 515 NGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGR 574
Query: 381 VYWADAYLDYIEVVDYEGKGRQTIIQG-ILIEHLYGLTVFENYLYATNSDNANAQQKTSV 439
+YW D+ L I +D G R+TI++ + H + L VFE+ ++ T+ N ++
Sbjct: 575 LYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIIN------EAI 628
Query: 440 IRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA-- 496
NR ++ ++ + + ++H QPR + CE GGC +CL A
Sbjct: 629 FSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPR-GVNWCERTTLSN-GGCQYLCLPAPQ 686
Query: 497 -NSHKAR-TCRCRSGFSLGSDGKSC 519
N H + TC C G L D +SC
Sbjct: 687 INPHSPKFTCACPDGMLLARDMRSC 711
Score = 185 bits (469), Expect = 1e-45
Identities = 101/260 (38%), Positives = 132/260 (50%), Gaps = 23/260 (8%)
Query: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIP 909
PP C EF C + +CI ++ CD D DCLD SDEA C TC F+C ++ CIP
Sbjct: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS--CPVLTCGPASFQCNSSTCIP 162
Query: 910 NRWLCDGDNDCGNSEDESNATC--------SARTCPPNQFSCASGRCIPISWTCDLDDDC 961
W CD D DC + DE C + C +F C SG CI SW CD DC
Sbjct: 163 QLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDC 222
Query: 962 GDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSC---SST 1018
D+SDE +CA TC P +F C++G CI+ + +CD + DC D SDE GC +
Sbjct: 223 KDKSDEE-NCAVATCRP-DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPN 280
Query: 1019 QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANC-TNQATRPPGGC-HTDE-----FQCRL 1071
+FKC+SG CI C+ DC D+SDE C TN+ GGC H ++C
Sbjct: 281 KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLC 340
Query: 1072 -DGLCIPLRWRCDGDTDCMD 1090
DG + + RC+ +C D
Sbjct: 341 PDGFQLVAQRRCEDIDECQD 360
Score = 185 bits (469), Expect = 1e-45
Identities = 125/397 (31%), Positives = 199/397 (50%), Gaps = 28/397 (7%)
Query: 1857 CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPNDKSDA 1914
CSQLC+ E C C G+ L +AC+ VGS +L ++ +R + LD ++ + +
Sbjct: 364 CSQLCV-NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT-S 421
Query: 1915 LVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR----EDVVTNGIGRVEGI 1970
L+P V +D ++ IYW D+ I + D+ + V++ I +G+
Sbjct: 422 LIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
Query: 1971 AVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQY 2030
AVDWI NIYWTD + VA G R + + KPRAI V P G+++WT+WG
Sbjct: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
Query: 2031 PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVV 2090
+I++ L+G + LV +I WPNGI++D G+LYW D++ I ID+ G NR+ +
Sbjct: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV-NGGNRKTI 598
Query: 2091 LSSNN--MDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVF 2148
L FS++VFED ++W+D N +I ++ +D L + + +D+ +F
Sbjct: 599 LEDEKRLAHPFSLAVFEDKVFWTD--IINEAIFSANRLTGSDVNLLAENL-LSPEDMVLF 655
Query: 2149 -NRDRQKGTNVC---AVANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCREYA 2198
N + +G N C ++NGGCQ LCL + + CAC GM LA D SC A
Sbjct: 656 HNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEA 715
Query: 2199 GYLLYSERTILKSIHLSDE--RNLNAPVQPFEDPEHM 2233
+ ++ T + +S R + +P D +
Sbjct: 716 EAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRL 752
Score = 174 bits (440), Expect = 2e-42
Identities = 124/387 (32%), Positives = 190/387 (49%), Gaps = 37/387 (9%)
Query: 473 VRSHACEN-DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYG 531
V CE+ D+ P CS +C+ N C+C GF L K+CK +L +
Sbjct: 347 VAQRRCEDIDECQDPDTCSQLCV--NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFT 404
Query: 532 KGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG- 590
+R M + E+ I NL N ALD + IY++D + +I ++D
Sbjct: 405 NRHE--VRKMTLDRS---EYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRA 459
Query: 591 ---TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKM 647
+ +T++ I +G+AVDW+ N+YWTD T+SVA + RKTL
Sbjct: 460 HGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDS-VLGTVSVA--DTKGVKRKTLFRENG 516
Query: 648 THPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF-VTSKTVLWPNGLSL 706
+ PRAIVVDP++G+MYWTDW K + G ++G DI+ + ++ + WPNG++L
Sbjct: 517 SKPRAIVVDPVHGFMYWTDWGTPAKIKKGG------LNGV--DIYSLVTENIQWPNGITL 568
Query: 707 DIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSV 765
D+ +GRLYWVD+ I +I +NG +RK + E + L H F L + +FWT+ + ++
Sbjct: 569 DLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAI 628
Query: 766 YRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCR---VNNGGCSSLCLATP 822
+ R G V LL ++ ++ Q G N C ++NGGC LCL P
Sbjct: 629 FSANRLTGS---DVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAP 685
Query: 823 GSR------QCACAEDQVLDADGVTCL 843
CAC + +L D +CL
Sbjct: 686 QINPHSPKFTCACPDGMLLARDMRSCL 712
Score = 152 bits (384), Expect = 7e-36
Identities = 103/324 (31%), Positives = 136/324 (41%), Gaps = 71/324 (21%)
Query: 2519 AVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCK----------- 2567
AV C ++EF+C +G+CI++ CDG C+D SDE C S CK
Sbjct: 22 AVGDRCE-RNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVN 80
Query: 2568 --------------------------KTFRQ----CSNGRCVSNMLWCNGADDCGDGSDE 2597
KT Q C +G+C+S C+ DC DGSDE
Sbjct: 81 RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
Query: 2598 IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDE--MNC--------SATDCSSY 2647
C CG F+C TCI C+ DCED SDE C ++ CS++
Sbjct: 141 ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAF 200
Query: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR 2707
+ G C SW CDG DC D SDE +C C + F C G
Sbjct: 201 EFHCLSGE----------CIHSSWRCDGGPDCKDKSDEENCAVA---TCRPDEFQCSDGN 247
Query: 2708 CIPMSWTCDKEDDCEHGEDETHC-NKFCSEA--QFECQNHRCISKQWLCDGSDDCGDGSD 2764
CI S CD+E DC+ DE C N E +F+C + CI+ +C+ + DC D SD
Sbjct: 248 CIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSD 307
Query: 2765 E-AAHCEGKTCGPSSFSCPGTHVC 2787
E C C ++ C +HVC
Sbjct: 308 EPIKECGTNECLDNNGGC--SHVC 329
Score = 142 bits (358), Expect = 8e-33
Identities = 103/330 (31%), Positives = 139/330 (42%), Gaps = 62/330 (18%)
Query: 3311 GGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCP 3370
G + CP + R C + QFVC +D+ DC D SDE CP
Sbjct: 98 GSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDR------------DCLDGSDE-ASCP 144
Query: 3371 EFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDE--ANC--------DIHVCLPSQFKC 3420
C P FQC++ C + CD D DC+D SDE C D C +F C
Sbjct: 145 VLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC 204
Query: 3421 TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV 3480
+ CI +RC+G +C D DE +C TC P++FQCS CI CDR+ DC
Sbjct: 205 L-SGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCS-DGNCIHGSRQCDREYDCK 262
Query: 3481 DGSDEPANCTQMTC--GVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEP 3538
D SDE C +T G ++F+C SG CI C+ DC D SDEP +EC C
Sbjct: 263 DMSDE-VGCVNVTLCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDEPIKECGTNECLD 320
Query: 3539 ---------------YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCA 3583
Y+ C + + + +C+ ++C D P CS+ C
Sbjct: 321 NNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD--------PDTCSQ---LCV 369
Query: 3584 NGRCIAGRWKCDGDHDCADGSDEKDCTPRC 3613
N + G +KC C +G T C
Sbjct: 370 N---LEGGYKC----QCEEGFQLDPHTKAC 392
Score = 142 bits (358), Expect = 8e-33
Identities = 95/357 (26%), Positives = 165/357 (46%), Gaps = 28/357 (7%)
Query: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYNYI 1606
CS LC +N C C +L C +L + + E+R + LD Y +
Sbjct: 364 CSQLC-VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
Query: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING----TGVETVVSADLPNAHG 1662
I P++ NV LD + R+YWSD+ + I ++ + +TV+S D+ G
Sbjct: 423 I----PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
Query: 1663 LAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDG 1721
LAVDW+ N++WT D+ ++VA G + + + +P +VV P+ G +YWTD
Sbjct: 479 LAVDWIHSNIYWT--DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW 536
Query: 1722 DNISMANMDGSNRTLLFS----GQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLE 1777
+ G N ++S + P G+ +D +LYW+ S H+I+ +++G +
Sbjct: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
Query: 1778 VIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYD 1837
I +L +LA+ DK++W D ++E + + ++ GS +L + M ++
Sbjct: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
Query: 1838 ESIQLDHKGTNPC---SVNNGDCSQLCLPTSETTR-----SCMCTAGYSLRSGQQAC 1886
Q +G N C +++NG C LCLP + +C C G L ++C
Sbjct: 657 NLTQ--PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Score = 136 bits (343), Expect = 4e-31
Identities = 107/389 (27%), Positives = 185/389 (47%), Gaps = 47/389 (12%)
Query: 2166 CQQLCLYRGRGQRACACAHGMLAEDGASCREYAG---YLLYSERTILKSIHLSDERNLNA 2222
C QLC+ G + C C G + + G YL ++ R ++ + L +R+
Sbjct: 364 CSQLCVNLEGGYK-CQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTL--DRSEYT 420
Query: 2223 PVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRIT----- 2277
+ P +++NV+AL + + NRI++SD+ I D + ++
Sbjct: 421 SLIP-----NLRNVVALDTEVAS-------NRIYWSDLSQRMICSTQLDRAHGVSSYDTV 468
Query: 2278 IVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAF 2337
I ++ + +GLA +YWT T++ V T+ +R+T+ +G PRA
Sbjct: 469 ISRDIQAPDGLAVDWIHSNIYWTDSVLGTVS---VADTK--GVKRKTLFRENGSK-PRAI 522
Query: 2338 VLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDAT 2397
V+D M+WT+W I + L+G ++ +L+ ++I+ PNG+ +D + +LY+ D+
Sbjct: 523 VVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
Query: 2398 LDKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKL 2455
L I + +G +R IL+ E HPF LAV+ + +FWTD + A+ AN+ GS++ L
Sbjct: 582 LHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641
Query: 2456 LRVDIPQQPMGIIAVANDTNSCELSPCR---INNGGCQDLCLLT-----HQGHVNCSCRG 2507
L ++ P ++ N T ++ C ++NGGCQ LCL H C+C
Sbjct: 642 LAENL-LSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
Query: 2508 GRILQDDLTCRAVNSSCRAQDEFECANGE 2536
G +L D+ SC + E A E
Sbjct: 701 GMLLARDM------RSCLTEAEAAVATQE 723
Score = 114 bits (286), Expect = 2e-24
Identities = 79/237 (33%), Positives = 106/237 (44%), Gaps = 42/237 (17%)
Query: 2809 AAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPE-CEYPTCGPSEFRCAN 2867
AAG C+ EF CQ+ +CI +VCD +C DGSDES E C TC +F C
Sbjct: 18 AAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGG 77
Query: 2868 --GRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCN 2925
RC+ + W CDG+ DC + SDE P SQ+ +F C G+C++ +C+
Sbjct: 78 RVNRCI-PQFWRCDGQVDCDNGSDEQGCPPKTCSQD-------EFRCHDGKCISRQFVCD 129
Query: 2926 GQDDCGDSSDERGCHINEC-----------LSRKLSGCSQ--DCEDLKIGFKCRCRPGFR 2972
DC D SDE C + C +L C DCED + RCR +
Sbjct: 130 SDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYV 189
Query: 2973 LKDDGRTCADVDECSTTFPC-SQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEE 3028
+ D C+ + F C S CI H S++C G P CK +DEE
Sbjct: 190 FQGDSSPCSAFE-----FHCLSGECI--HSSWRC---------DGGP-DCKDKSDEE 229
Score = 108 bits (270), Expect = 1e-22
Identities = 78/275 (28%), Positives = 111/275 (40%), Gaps = 49/275 (17%)
Query: 2505 CRGGRILQDDLTCRAVNSSCRAQDE------------FECANGECINFSLTCDGVPHCKD 2552
C G+ + C + DE F+C + CI CD P C+D
Sbjct: 116 CHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCED 175
Query: 2553 KSDEKPSYC--------NSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA 2604
SDE P C +S C C +G C+ + C+G DC D SDE C
Sbjct: 176 GSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVAT 235
Query: 2605 CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC-SATDCSSYFRLGVKGVLFQPCERT 2663
C EF+C DG CI S +C++ DC+D SDE+ C + T C + +
Sbjct: 236 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKC---------HS 286
Query: 2664 SLCYAPSWVCDGANDCGDYSDE--RDC--------PGVKRPRC---PLNY-FACPSGRCI 2709
C VC+ A DC D+SDE ++C G C + Y CP G +
Sbjct: 287 GECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL 346
Query: 2710 PMSWTCDKEDDCEHGEDETHCNKFC--SEAQFECQ 2742
C+ D+C +D C++ C E ++CQ
Sbjct: 347 VAQRRCEDIDEC---QDPDTCSQLCVNLEGGYKCQ 378
Score = 77.0 bits (188), Expect = 4e-13
Identities = 59/184 (32%), Positives = 73/184 (39%), Gaps = 29/184 (15%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
PKTCS +F C D CIS+ + CD +RDC DGSDEA CP C P C +
Sbjct: 106 PKTCSQDEFRCHDG-KCISRQFVCDSDRDCLDGSDEAS--CP---VLTCGPASFQC-NSS 158
Query: 84 LCVPMSRLCNGVQDCMDGSDEGPH--------------CRELQGNCSRLGCQHHCVPTLD 129
C+P C+ DC DGSDE P C + +C C H
Sbjct: 159 TCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDG 218
Query: 130 GPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFIC-------GCVEGYLLQ 182
GP C S + A D +CS G C D + C GCV L +
Sbjct: 219 GPDCKDKSDEENCAVATCRPDEFQCS-DGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCE 277
Query: 183 PDNR 186
N+
Sbjct: 278 GPNK 281
Score = 65.9 bits (159), Expect = 9e-10
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 16 LVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPN 75
L AA C +F C+D CIS W CDG +C DGSDE+ E C + C+
Sbjct: 16 LAAAGTAVGDRCERNEFQCQDG-KCISYKWVCDGSAECQDGSDESQETC---LSVTCKSG 71
Query: 76 EHNCLG-TELCVPMSRLCNGVQDCMDGSDE 104
+ +C G C+P C+G DC +GSDE
Sbjct: 72 DFSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
Score = 34.7 bits (78), Expect = 2.2
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAE 831
D ++ GTN+C NNGGCS +C +C C +
Sbjct: 307 DEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 472 bits (1215), Expect = e-132
Identities = 294/815 (36%), Positives = 417/815 (51%), Gaps = 126/815 (15%)
Query: 3024 VTDEEPFLIFANRYYLRKLNL-DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSM 3082
+ +E F+++A R + + +L G+ L GL AVALDFDY +YW+D+ +
Sbjct: 754 LAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLAL--DV 811
Query: 3083 IRRMHLNGSNVQ-VLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR-TVLV 3140
I+R+ LNGS Q V+ +GL + LA + + LYW D G IEV+ +G +R T++
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 3141 SSGLREPRALVVDVQNGYLYWTDWGD-HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYV 3199
SS L PRALV+ Q G ++WTDWGD I R MDGS+ +V + WPNG+++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 3200 TERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHK 3259
+ IYW DA + IE + G R V+L ++PH +A+ +F++ +YW DW SI RA K
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 3260 TTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCL------------- 3306
+G+ +L + L MD+ +F+ + + ++ C CS LCL
Sbjct: 989 YSGSQMEILANQLTGLMDMKIFY--KGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPE 1044
Query: 3307 -----LSPGGGHKCACPTNFYLGSDGRTCV---SNCTASQFVCKNDKCIPFWWKCDTEDD 3358
+ P G C CP + L ++ TCV + C +Q+ C N CI W CD ++D
Sbjct: 1045 DVSSSVLPSGDLMCDCPQGYQLKNN--TCVKEENTCLRNQYRCSNGNCINSIWWCDFDND 1102
Query: 3359 CGDHSDEPPDCPEFKC-RPGQFQC-STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPS 3416
CGD SDE +CP C QF+C +G C ++ CD ++DC DNSDE++C++H C
Sbjct: 1103 CGDMSDE-RNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSD 1161
Query: 3417 QFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEV--TCAPNQFQCSITKRCIPRVWVCD 3474
++ C ++ CI + C+G ++C D DE +C + TC + FQC CIP+ W CD
Sbjct: 1162 EYNC-SSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCR-NGHCIPQRWACD 1219
Query: 3475 RDNDCVDGSDE-PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEE--- 3530
D DC DGSDE P NC + G FRC +G CIP+ CDG DC DGSDE E
Sbjct: 1220 GDTDCQDGSDEDPVNCEKKCNG---FRC-PNGTCIPSSKHCDGLRDCSDGSDEQHCEPLC 1275
Query: 3531 --------------------CD------------------------ERTCEPYQFRCKNN 3546
CD + C+ + F+C+N
Sbjct: 1276 THFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNG 1335
Query: 3547 RCVPGRWQCDYDNDCGDNSDEESC---TPRP-CSE-SEFSCANGRCIAGRWKCDGDHDCA 3601
C+ W+CD +DCGD SDE +C T P CS +F C NG CI RWKCD ++DC
Sbjct: 1336 VCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCG 1395
Query: 3602 DGSDEKDC---------TP---RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC-- 3647
D SDEKDC TP C + ++C SG C+ W CD DC DGSDEEAC
Sbjct: 1396 DWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPL 1455
Query: 3648 ---------GTGVRTCPLDEFQCNN-TLCKPLAWKCDGEDDCGDNSDE-NPEECARFVCP 3696
T + C EF+C+ C P +CDG DC D DE N + C
Sbjct: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTC- 1514
Query: 3697 PNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731
+R F+C++ C+ + +CDG +C D +DE+ C
Sbjct: 1515 MSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 379 bits (974), Expect = e-104
Identities = 257/804 (31%), Positives = 358/804 (44%), Gaps = 138/804 (17%)
Query: 2233 MKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVG--SVEGLAY 2290
++ +AL FDY N +++SD+ IQ++ +GS ++ N G +VE LA+
Sbjct: 787 LRAAVALDFDYEH-------NCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAF 839
Query: 2291 HRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTN 2350
LYW I + P R T++ S D PRA VL + +MFWT+
Sbjct: 840 EPLSQLLYWVDAGFKKI-----EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTD 894
Query: 2351 WNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSH 2410
W + P I R+ + G+ L+ +D++ PNG+++D + +Y++DA L+ IER + G
Sbjct: 895 WGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDD--QWIYWTDAYLECIERITFSGQQ 952
Query: 2411 RYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQ-QPMGIIA 2469
R VIL + P HP+ +AV+ I+W DW + ++ RA+K+ GS M++L + M I
Sbjct: 953 RSVILDNLP-HPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY 1011
Query: 2470 VANDT--NSCELSPCRI-------NNGGC---QDLCL-LTHQGHVNCSCRGGRILQDDLT 2516
+T N+C PC + N+ C +D+ + G + C C G L+++ T
Sbjct: 1012 KGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNN-T 1070
Query: 2517 CRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG 2576
C ++C ++++ C+NG CIN CD C D SDE+ FR +G
Sbjct: 1071 CVKEENTC-LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESG 1129
Query: 2577 RCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDE 2636
C+ C+ DDCGD SDE C C E+ C G CI +S C+ DC D SDE
Sbjct: 1130 TCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Query: 2637 MNCSATDCSSYFRLGVKGVLFQPCE------RTSLCYAPSWVCDGANDCGDYSDERDCPG 2690
NC+A ++ CE R C W CDG DC D SDE
Sbjct: 1190 ANCTA--------------IYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC 1235
Query: 2691 VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-------------------- 2730
K+ N F CP+G CIP S CD DC G DE HC
Sbjct: 1236 EKK----CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLF 1291
Query: 2731 ------------------------------NKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
+K C E F+CQN CIS W CDG DDCG
Sbjct: 1292 HSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCG 1351
Query: 2761 DGSDEAAHCEGKTCGPS-----SFSCPGTHVCVPERWLCDGDKDCADGADES-------I 2808
D SDE A+CE T P+ F C H C+P RW CD + DC D +DE +
Sbjct: 1352 DYSDE-ANCENPTEAPNCSRYFQFRCENGH-CIPNRWKCDRENDCGDWSDEKDCGDSHIL 1409
Query: 2809 AAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE------------SPECEYP 2856
STC + C + C+ +VCD RDCADGSDE S +
Sbjct: 1410 PFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469
Query: 2857 TCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGR 2916
C EF C + CDG DC D DEA +C + S +F C G
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA----NCPTHSTLTCMSREFQCEDGE 1525
Query: 2917 -CVAEALLCNGQDDCGDSSDERGC 2939
C+ + C+G DC D SDE+ C
Sbjct: 1526 ACIVLSERCDGFLDCSDESDEKAC 1549
Score = 357 bits (916), Expect = 1e-97
Identities = 249/737 (33%), Positives = 355/737 (48%), Gaps = 108/737 (14%)
Query: 519 CKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADT 578
C E F++Y R I R D+ + ++ +P+ L ALDF E +Y++D
Sbjct: 752 CPLAEENEFILYAV-RKSIYR-YDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDL 807
Query: 579 TSYLIGRQKIDG-TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQ 637
+I R ++G T +E I+ G+ VE +A + + LYW D G KK I VA +
Sbjct: 808 ALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKK-IEVANPD--GD 864
Query: 638 TRKTLIEGK-MTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSK 696
R T++ + PRA+V+ P G M+WTDW D + G + R+ MDGS + S+
Sbjct: 865 FRLTIVNSSVLDRPRALVLVPQEGVMFWTDWG----DLKPG-IYRSNMDGSAA-YHLVSE 918
Query: 697 TVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLF 756
V WPNG+S+D +YW DA+ + IE I +G R ++ + L H + + N ++
Sbjct: 919 DVKWPNGISVDDQW--IYWTDAYLECIERITFSGQQRSVILDN--LPHPYAIAVFKNEIY 974
Query: 757 WTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSS 816
W ++ S++R + G + +L ++ + +++++ + + G+N C CS
Sbjct: 975 WDDWSQLSIFRASKYSGSQ---MEILANQLTGLMDMKIF-YKGKNTGSNACVPRP--CSL 1028
Query: 817 LCLATPG-SRQCACAED---QVLDADGVTC-------LANPSYVPPPQ-CQPGEFACANS 864
LCL SR C C ED VL + + C L N + V C ++ C+N
Sbjct: 1029 LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNG 1088
Query: 865 RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSD-RFKC-ENNRCIPNRWLCDGDNDCGN 922
CI W CD DNDC D SDE C C D +F+C E+ CIP + CD ++DCG+
Sbjct: 1089 NCINSIWWCDFDNDCGDMSDERN--CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGD 1146
Query: 923 SEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCA-YPTCFPLTQ 981
+ DES+ C C ++++C+SG CI SW CD D+DC D SDE+ A Y TC +
Sbjct: 1147 NSDESH--CEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTC-EASN 1203
Query: 982 FTCNNGRCININWRCDNDNDCGDNSDE--AGCSHSCSSTQFKCNSGRCIPEHWTCDGDND 1039
F C NG CI W CD D DC D SDE C C+ F+C +G CIP CDG D
Sbjct: 1204 FQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG--FRCPNGTCIPSSKHCDGLRD 1261
Query: 1040 CGDYSDETHAN--CT-----------------------------NQATRPPGGCHTDE-- 1066
C D SDE H CT + GC D
Sbjct: 1262 CSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEF 1321
Query: 1067 --------FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHV--CDPSVKFGCKDSA 1116
FQC+ +G+CI L W+CDG DC D SDE +CE T C +F C ++
Sbjct: 1322 HKVCDEFGFQCQ-NGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRC-ENG 1379
Query: 1117 RCISKAWVCDGDNDCEDNSDEENCES-----------LACRPPSHPCANNTSVCLPPDKL 1165
CI W CD +NDC D SDE++C C P + C++ T C+ +
Sbjct: 1380 HCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGT--CVMDTWV 1437
Query: 1166 CDGNDDCGDGSDEGELC 1182
CDG DC DGSDE E C
Sbjct: 1438 CDGYRDCADGSDE-EAC 1453
Score = 233 bits (594), Expect = 3e-60
Identities = 144/405 (35%), Positives = 179/405 (44%), Gaps = 80/405 (19%)
Query: 805 NKCRVNNGGCSS-LCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACAN 863
++CR + CSS +C+ + S C D +D C A C+ F C N
Sbjct: 1156 HQCRSDEYNCSSGMCIRS--SWVCDGDNDCRDWSDEANCTAIYH-----TCEASNFQCRN 1208
Query: 864 SRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDC--- 920
CI +RW CDGD DC D SDE P C + + F+C N CIP+ CDG DC
Sbjct: 1209 GHCIPQRWACDGDTDCQDGSDEDPVNCEKKC---NGFRCPNGTCIPSSKHCDGLRDCSDG 1265
Query: 921 ---------------------------------------GNSEDESNATCSA-----RTC 936
G+ ED + A CS + C
Sbjct: 1266 SDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVC 1325
Query: 937 PPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPT----CFPLTQFTCNNGRCINI 992
F C +G CI + W CD DDCGD SDE A+C PT C QF C NG CI
Sbjct: 1326 DEFGFQCQNGVCISLIWKCDGMDDCGDYSDE-ANCENPTEAPNCSRYFQFRCENGHCIPN 1384
Query: 993 NWRCDNDNDCGDNSDEAGCSHS------------CSSTQFKCNSGRCIPEHWTCDGDNDC 1040
W+CD +NDCGD SDE C S C ++C+SG C+ + W CDG DC
Sbjct: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
Query: 1041 GDYSDETH----ANCTNQATRPP-GGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK 1095
D SDE AN T +T G C EF+C CIP RCDG DC D DE
Sbjct: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504
Query: 1096 SCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
+C + + S +F C+D CI + CDG DC D SDE+ C
Sbjct: 1505 NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 231 bits (589), Expect = 1e-59
Identities = 131/348 (37%), Positives = 167/348 (47%), Gaps = 50/348 (14%)
Query: 3519 DCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCS 3576
DC G C +E TC Q+RC N C+ W CD+DNDCGD SDE +C C
Sbjct: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD 1118
Query: 3577 -ESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLRWRCD 3633
+++F C +G CI +KCD + DC D SDE C +C D++ C SG CI W CD
Sbjct: 1119 LDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCD 1178
Query: 3634 ADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARF 3693
D DC D SDE C TC FQC N C P W CDG+ DC D SDE+P C +
Sbjct: 1179 GDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK- 1237
Query: 3694 VCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRN-Q 3752
FRC N C+ + CDG +C DG+DE+ CEP H +F+C+N Q
Sbjct: 1238 ---KCNGFRCPNG-TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF------MDFVCKNRQ 1287
Query: 3753 RCLSSSLRCNMFDDCGDGSDEE----DCSIDPKL--------TSCATNASI--------- 3791
+CL S+ C+ C DGSDE+ CS DP+ C I
Sbjct: 1288 QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGM 1347
Query: 3792 --CG---DEARCVRTEKAAYCA------CRSGFHTVPGQPGCQDINEC 3828
CG DEA C +A C+ C +G H +P + C N+C
Sbjct: 1348 DDCGDYSDEANCENPTEAPNCSRYFQFRCENG-HCIPNRWKCDRENDC 1394
Score = 176 bits (447), Expect = 4e-43
Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 14/294 (4%)
Query: 1892 FLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISR-AK 1950
F+LY+V + I L +P++G AV +DF E++ +YW D+ L I R
Sbjct: 760 FILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
Query: 1951 RDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVI-SQGLDK 2009
T +E ++ +G+ VE +A + ++ +YW D GF IEVA +G FR ++ S LD+
Sbjct: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDR 877
Query: 2010 PRAITVHPEKGYLFWTEWGQY-PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYW 2068
PRA+ + P++G +FWT+WG P I RS +DG+ LV+ + WPNGISVD D +YW
Sbjct: 878 PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYW 935
Query: 2069 CDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNA 2128
DA + IERI +G+ R V+L N ++++VF++ IYW D + SI R SK +
Sbjct: 936 TDAYLECIERITF-SGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQL--SIFRASKYSG 991
Query: 2129 TDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC 2182
+ L + L D+K+F + + G+N C C LCL + R+C C
Sbjct: 992 SQMEILANQL-TGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRC 1042
Score = 176 bits (445), Expect = 6e-43
Identities = 103/299 (34%), Positives = 162/299 (54%), Gaps = 17/299 (5%)
Query: 1270 FIIFSNRHEIRRIDLHKGDYSVL-VPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLD 1328
FI+++ R I R DL G L + GLR +ALDF + LYW+D+ D I R L
Sbjct: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR--LCL 817
Query: 1329 NGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI-E 1387
NG+ T EV+I GL T E LA + ++ +YWV++ +IEVA DG R T++ + +
Sbjct: 818 NGS-TGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 1388 HPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKR 1447
PRA+ L P++G++FWTDW P I ++M G+ H + WPNG++VD ++
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSA--AYHLVSEDVKWPNGISVD--DQW 932
Query: 1448 ILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKW 1507
I W DA + I + G +L + L HP+A+ ++ E+YW DW ++ +A+K+
Sbjct: 933 IYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKY 989
Query: 1508 TGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACP 1566
+G + ++ T D+++++ + N C PCS LCL N + SC CP
Sbjct: 990 SGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR----PCSLLCLPKANNSRSCRCP 1043
Score = 149 bits (377), Expect = 5e-35
Identities = 136/504 (26%), Positives = 212/504 (42%), Gaps = 106/504 (21%)
Query: 3955 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLI-SGMIDEPHAIVVDPLRG 4013
SGL+ +A + ++ +YW D+G IEVA G+ R T++ S ++D P A+V+ P G
Sbjct: 829 SGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEG 888
Query: 4014 TMYWSDWGN-HPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSI 4072
M+W+DWG+ P I + MDG+ LV ++++WP G++VD ++ +YW DA L I I
Sbjct: 889 VMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERI 946
Query: 4073 RLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSH 4132
+G V D+ L HP++I VF++ IY + +F+ K+ S + L L+
Sbjct: 947 TFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTG 1003
Query: 4133 ASDVVLYHQHKQPEVTNPCDRKKCEWLCL------------------LSPSGP-VCTCPN 4173
D+ ++++ K +N C + C LCL + PSG +C CP
Sbjct: 1004 LMDMKIFYKGKNTG-SNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQ 1062
Query: 4174 GKRLDNGTCVPVPSPTPPPDAPRPGTC---NLQCFNGGSCFLN----------ARRQPKC 4220
G +L N TCV TC +C N G+C + +
Sbjct: 1063 GYQLKNNTCV-----------KEENTCLRNQYRCSN-GNCINSIWWCDFDNDCGDMSDER 1110
Query: 4221 RCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNS 4280
C C+LD + C+ GTC P + KC + G ++ S
Sbjct: 1111 NCPTTI----CDLDTQF-RCQESGTC-----------IPLSY---KCDLEDDCGDNSDES 1151
Query: 4281 TCTVNQGNQPQCRCLPGFL--------GDR-CQ-----------YRQCSG---YCENFGT 4317
C ++Q + C G GD C+ Y C C N G
Sbjct: 1152 HCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN-GH 1210
Query: 4318 C---QMAADGSRQCRCTAYFEGSRCEVNKCS--RCLEGACVVNKQSGDVTCNCTDGRVAP 4372
C + A DG C+ + + CE KC+ RC G C+ + + D +C+DG
Sbjct: 1211 CIPQRWACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQ 1269
Query: 4373 SCLTCVGH-----CSNGGSCTMNS 4391
C H C N C +S
Sbjct: 1270 HCEPLCTHFMDFVCKNRQQCLFHS 1293
Score = 130 bits (326), Expect = 4e-29
Identities = 100/319 (31%), Positives = 152/319 (47%), Gaps = 26/319 (8%)
Query: 1580 EFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAI 1639
E +F+LYA + I DL + + + + LD+D +YWSD+ I
Sbjct: 756 EENEFILYAVRKSIYRYDLASGATEQL---PLTGLRAAVALDFDYEHNCLYWSDLALDVI 812
Query: 1640 KRAFING-TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV 1698
+R +NG TG E ++++ L LA + +S+ L+W D K+I VA DG F+ +V
Sbjct: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWV--DAGFKKIEVANPDGDFRLTIV 870
Query: 1699 QG--LEQPHGLVVHPLRGKLYWTD-GD---NISMANMDGSNRTLLFSGQ-KGPVGLAIDF 1751
L++P LV+ P G ++WTD GD I +NMDGS L S K P G+++D
Sbjct: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
Query: 1752 PESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGT 1811
+ +YW + I R G VI L A+A+ ++++W D +
Sbjct: 930 -DQWIYWTDAYLECIERITFSGQQRSVI---LDNLPHPYAIAVFKNEIYWDDWSQLSIFR 985
Query: 1812 CSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSC 1871
SK GS +L N T +M MK++ + + G+N C CS LCLP + +RSC
Sbjct: 986 ASKYSGSQMEILANQLTGLMDMKIFYKG---KNTGSNACVPR--PCSLLCLPKANNSRSC 1040
Query: 1872 MCTAGYS---LRSGQQACE 1887
C S L SG C+
Sbjct: 1041 RCPEDVSSSVLPSGDLMCD 1059
Score = 128 bits (321), Expect = 1e-28
Identities = 84/249 (33%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 2530 FECANGECINFSLTCDGVPHCKDKSDEK--PSYCNSRRCKKTFR-QCSNGRCVSNMLWCN 2586
F+C NG CI+ CDG+ C D SDE + + C + F+ +C NG C+ N C+
Sbjct: 1330 FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCD 1389
Query: 2587 GADDCGDGSDEIPCNKT-----------ACGVGEFRCRDGTCIGNSSRCNQFVDCEDASD 2635
+DCGD SDE C + C +RC GTC+ ++ C+ + DC D SD
Sbjct: 1390 RENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSD 1449
Query: 2636 EMNC----SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWV-CDGANDCGDYSDERDCPG 2690
E C + T S+ +LG C + C P+W CDG DC D DE +CP
Sbjct: 1450 EEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCI-PNWKRCDGHQDCQDGRDEANCPT 1508
Query: 2691 VKRPRCPLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISK 2749
C F C G CI +S CD DC DE K CS+ E ++ +
Sbjct: 1509 HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE----KACSD---ELTVYKVQNL 1561
Query: 2750 QWLCDGSDD 2758
QW D S D
Sbjct: 1562 QWTADFSGD 1570
Score = 108 bits (269), Expect = 2e-22
Identities = 86/328 (26%), Positives = 155/328 (47%), Gaps = 31/328 (9%)
Query: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR 260
+L A ++I L+ + T R A+DF Y + + W + Q
Sbjct: 761 ILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC---- 816
Query: 261 MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDL 320
L G + I I+ L VE +A + L+ Y+VD +I V N +GD +T+++
Sbjct: 817 ---LNGSTGQEVI-INSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872
Query: 321 ELYN-PKGIALDPAMGKVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVS 378
+ + P+ + L P G +F+TD+G + P + R +MDG LV + +P+GI++D
Sbjct: 873 SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--D 930
Query: 379 RLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTS 438
+ +YW DAYL+ IE + + G+ R I+ + H Y + VF+N +Y + + S
Sbjct: 931 QWIYWTDAYLECIERITFSGQQRSVILDN--LPHPYAIAVFKNEIYWDD------WSQLS 982
Query: 439 VIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANS 498
+ R ++++ ++ +++ G + + + S+AC P CS +C L +
Sbjct: 983 IFRASKYSGSQMEILAN-QLTGLMDMKIFYKGKNTGSNAC------VPRPCSLLC-LPKA 1034
Query: 499 HKARTCRCRSGFS---LGSDGKSCKKPE 523
+ +R+CRC S L S C P+
Sbjct: 1035 NNSRSCRCPEDVSSSVLPSGDLMCDCPQ 1062
Score = 77.4 bits (189), Expect = 3e-13
Identities = 54/164 (32%), Positives = 69/164 (42%), Gaps = 33/164 (20%)
Query: 14 SALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICP-------- 65
S ++ + P TC P + C TC+ W CDG RDC DGSDE E CP
Sbjct: 1406 SHILPFSTPGPSTCLPNYYRCSSG-TCVMDTWVCDGYRDCADGSDE--EACPLLANVTAA 1462
Query: 66 --QSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC---SRLGC 120
++ RC E C + C+P + C+G QDC DG DE NC S L C
Sbjct: 1463 STPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDE--------ANCPTHSTLTC 1514
Query: 121 QHHCVPTLDGPTCY-----CNSSFQL--QADGKTCKDFDECSVY 157
DG C C+ ++D K C DE +VY
Sbjct: 1515 MSREFQCEDGEACIVLSERCDGFLDCSDESDEKACS--DELTVY 1556
Score = 76.3 bits (186), Expect = 7e-13
Identities = 56/165 (33%), Positives = 70/165 (42%), Gaps = 27/165 (16%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQS-KAQRCQPNEHNCLGTEL 84
TC F CR+ CI + W CDG+ DC DGSDE P C + RC PN GT
Sbjct: 1198 TCEASNFQCRNG-HCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC-PN-----GT-- 1248
Query: 85 CVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQH---------------HCVPTLD 129
C+P S+ C+G++DC DGSDE HC L + C++ C D
Sbjct: 1249 CIPSSKHCDGLRDCSDGSDE-QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
Query: 130 GPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
+ S Q K C +F G C L DG CG
Sbjct: 1308 EDAAFAGCS-QDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCG 1351
Score = 72.4 bits (176), Expect = 1e-11
Identities = 51/150 (34%), Positives = 72/150 (48%), Gaps = 16/150 (10%)
Query: 31 QFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR 90
QF C++ TCI ++CD E DC D SDE+ + +C+ +E+NC + +C+ S
Sbjct: 1122 QFRCQESGTCIPLSYKCDLEDDCGDNSDES-----HCEMHQCRSDEYNC-SSGMCIRSSW 1175
Query: 91 LCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQH-HCVP---TLDGPT-CYCNSSFQLQA 143
+C+G DC D SDE +C + C S C++ HC+P DG T C S
Sbjct: 1176 VCDGDNDCRDWSDEA-NCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVN 1234
Query: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
K C F C GTC + DG C
Sbjct: 1235 CEKKCNGF-RCP-NGTCIPSSKHCDGLRDC 1262
Score = 72.4 bits (176), Expect = 1e-11
Identities = 38/95 (40%), Positives = 46/95 (48%), Gaps = 3/95 (3%)
Query: 11 PLLSALVAAAIDAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKA 69
PLL+ + AA+ C +F C TCI RCDG +DC DG DEA CP
Sbjct: 1454 PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEAN--CPTHST 1511
Query: 70 QRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
C E C E C+ +S C+G DC D SDE
Sbjct: 1512 LTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
Score = 56.2 bits (134), Expect = 7e-07
Identities = 38/102 (37%), Positives = 47/102 (46%), Gaps = 15/102 (14%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDE---APEICPQSKAQRCQPNEHNCLGT 82
TC Q+ C + CI+ W CD + DC D SDE IC RCQ + GT
Sbjct: 1077 TCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQES-----GT 1130
Query: 83 ELCVPMSRLCNGVQDCMDGSDEG----PHCRELQGNCSRLGC 120
C+P+S C+ DC D SDE CR + NCS C
Sbjct: 1131 --CIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMC 1170
Score = 54.3 bits (129), Expect = 3e-06
Identities = 38/138 (27%), Positives = 58/138 (42%), Gaps = 18/138 (13%)
Query: 2893 KNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGC 2952
KN C +E+ C +Q+ CS+G C+ C+ +DCGD SDER C C C
Sbjct: 1067 KNNTCVKEENTC-LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRC 1125
Query: 2953 SQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKC---LCVE 3009
+ + + +KC L+DD +D C +C Y C +C+
Sbjct: 1126 QESGTCIPLSYKC------DLEDDCGDNSDESHCE-----MHQC--RSDEYNCSSGMCIR 1172
Query: 3010 GYAPRGGDPHSCKAVTDE 3027
GD + C+ +DE
Sbjct: 1173 SSWVCDGD-NDCRDWSDE 1189
Score = 48.1 bits (113), Expect = 2e-04
Identities = 30/80 (37%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
K C F C++ + CIS W+CDG DC D SDEA P ++A C
Sbjct: 1323 KVCDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCENP-TEAPNCSRYFQFRCENGH 1380
Query: 85 CVPMSRLCNGVQDCMDGSDE 104
C+P C+ DC D SDE
Sbjct: 1381 CIPNRWKCDRENDCGDWSDE 1400
Score = 37.0 bits (84), Expect = 0.45
Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 41/197 (20%)
Query: 4230 KCE-LDQCWEHCRNGGTCAASPSGMPTC------RCPTGFTGP---KCTQQVCAGYCANN 4279
KC+ +D C ++ +P+ P C RC G P KC ++ G ++
Sbjct: 1343 KCDGMDDCGDYSDEAN--CENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Query: 4280 STCTVNQ----GNQPQCRCLPGFLGDRCQYRQC---SGYCENFGTCQMAADGSRQCRCTA 4332
C + CLP + RC C + C+ + C ADGS + C
Sbjct: 1401 KDCGDSHILPFSTPGPSTCLPNYY--RCSSGTCVMDTWVCDGYRDC---ADGSDEEACPL 1455
Query: 4333 YFE----GSRCEVNKCSR----CLEG-ACVVNKQSGDVTCNCTDGRVAPSC-----LTCV 4378
+ ++ +C R C + C+ N + D +C DGR +C LTC+
Sbjct: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCM 1515
Query: 4379 G---HCSNGGSCTMNSK 4392
C +G +C + S+
Sbjct: 1516 SREFQCEDGEACIVLSE 1532
Score = 35.4 bits (80), Expect = 1.3
Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 2357 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGS-HRYVIL 2415
SI R L+ L +R L D+ LY+SD LD I+R +GS + VI+
Sbjct: 768 SIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVII 827
Query: 2416 KS--EPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVAND 2473
S E V + ++W D + ++ AN + ++ + +P ++ V +
Sbjct: 828 NSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQE 887
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 415 bits (1067), Expect = e-115
Identities = 229/614 (37%), Positives = 322/614 (52%), Gaps = 68/614 (11%)
Query: 2732 KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPER 2791
K C + QF+C+N RCI W CD DDC D SDE C KTC S F+C H C+ ER
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGH-CIHER 102
Query: 2792 WLCDGDKDCADGADESIAAGCLYNSTCDDREFMC--QNRQCIPKHFVCDHDRDCADGSDE 2849
W CDG+++C DG+DES A C + C + +C+P + CD ++DC G+DE
Sbjct: 103 WKCDGEEECPDGSDESEAT--CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 2850 SP-ECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASS 2908
+ TC EF+C +G C+ + + C+ E DC D SDEA
Sbjct: 161 AGCATSLGTCRGDEFQCGDGTCVLAIK-HCNQEQDCPDGSDEAG---------------- 203
Query: 2909 QFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCR 2968
C G +NECL GCS C DLKIGF+C C
Sbjct: 204 ---CLQG-------------------------LNECLHNN-GGCSHICTDLKIGFECTCP 234
Query: 2969 PGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEE 3028
GF+L D +TC D+DEC CSQ C+N G +KC C GY +CKA +
Sbjct: 235 AGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFKCECYPGY-EMDLLTKNCKAAAGKS 292
Query: 3029 PFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQG--SMIRRM 3086
P LIF NR+ +R+++L NY+ L L N VALD + IYW D++ + S
Sbjct: 293 PSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDK 352
Query: 3087 HLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLRE 3146
+ +VL L +P+GLAVDWV ++YW D G TI V+ ++G R L S L E
Sbjct: 353 ASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSE 412
Query: 3147 PRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWA 3206
PRA+ VD G++YW+DWGD + I + G++G R +V I WPNG+TLD +++R+YW
Sbjct: 413 PRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWV 472
Query: 3207 DAREDYIEFASLDGSNRHVVLSQD--IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTN 3264
D++ + G NR ++S + H F + +FED V+WTD E ++I A++ G
Sbjct: 473 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLE 532
Query: 3265 KTLLISTLHRPMDLHVFHALRQPDVPNHPCKVN---NGGCSNLCLLSP-----GGGHKCA 3316
++L L+ P D+ +FH L+QP P+ C+++ NGGC LCL +P + CA
Sbjct: 533 ISILAENLNNPHDIVIFHELKQPRAPD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 591
Query: 3317 CPTNFYLGSDGRTC 3330
CP +LG D + C
Sbjct: 592 CPDTMWLGPDMKRC 605
Score = 403 bits (1036), Expect = e-111
Identities = 213/582 (36%), Positives = 313/582 (53%), Gaps = 29/582 (4%)
Query: 1010 GCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQC 1069
G + C QF+C + RCIP W CD D+DC D+SDE P C +F C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC--------PKKTCADSDFTC 93
Query: 1070 RLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC-KDSARCISKAWVCDGD 1128
+G CI RW+CDG+ +C D SDE VC P+ K C S +C+ +W CDG+
Sbjct: 94 D-NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGE 151
Query: 1129 NDCEDNSDEENCESL--ACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG---ELCD 1183
DCE +DE C + CR C + T C+ K C+ DC DGSDE + +
Sbjct: 152 KDCEGGADEAGCATSLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLN 209
Query: 1184 QCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243
+C NNGGCSH C+ G C+CP G +L D TC C CSQ C K
Sbjct: 210 ECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGY 267
Query: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD 1303
KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L+P L+N +ALD
Sbjct: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 327
Query: 1304 FHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVES 1363
++ + +YW D+ KIY + EV+I L +PEGLAVDW+ +IYW +S
Sbjct: 328 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 387
Query: 1364 NLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
I VA +DG R TL + ++ PRAIA+DP G ++W+DW +IE + ++G R
Sbjct: 388 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDR 446
Query: 1424 RTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFA 1483
+T+ + WPNG+T+D L +R+ W+D++ + S + G ++ +FLSHPF
Sbjct: 447 QTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
Query: 1484 VTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEAN 1543
+ ++ +V+WTD + AN+ G ++++ P D+ ++H +QP AP+ CE +
Sbjct: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
Query: 1544 -GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
G C +LCL +++ +CACP M L D CY
Sbjct: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 606
Score = 358 bits (919), Expect = 7e-98
Identities = 208/575 (36%), Positives = 290/575 (50%), Gaps = 41/575 (7%)
Query: 3613 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWK 3672
C+ DQFQC++ CIP WRCD D DC+D SDE+ C +TC +F C+N C WK
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHERWK 104
Query: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE 3732
CDGE++C D SDE+ C + VCP + C+ +CDG +C G DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792
C+ EF C + C+ + CN DC DGSDE C L C N C
Sbjct: 165 TSLGT---CRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL--QGLNECLHNNGGC 218
Query: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARN 3852
C + C C +GF + Q C DI+EC CSQ+C N KG C C
Sbjct: 219 SHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPG 275
Query: 3853 F---MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHV 3909
+ + T N CKA + L + +E+R + Y + ++V A+DV V
Sbjct: 276 YEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRI--DLVKRNYSRLIPMLKNVV--ALDVEV 330
Query: 3910 KAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVA 3969
R+YW + +SYR + A S+ +++ L L P G+A+DWV
Sbjct: 331 ATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LIDEQLHSPEGLAVDWVH 379
Query: 3970 GNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETA 4029
++YWTDSG I VA + G R+TL S + EP AI VDPLRG MYWSDWG+ KIE +
Sbjct: 380 KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKS 439
Query: 4030 AMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGL 4089
++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI +G + S L
Sbjct: 440 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 499
Query: 4090 SHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTN 4149
SHPF I VFED ++ N +F ++ + L L++ D+V++H+ KQP +
Sbjct: 500 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPD 559
Query: 4150 PCD-----RKKCEWLCLLSPS----GP--VCTCPN 4173
C+ CE+LCL +P P C CP+
Sbjct: 560 ACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 594
Score = 253 bits (646), Expect = 3e-66
Identities = 172/553 (31%), Positives = 253/553 (45%), Gaps = 70/553 (12%)
Query: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-----EICPQSKAQRCQPN 75
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
Query: 76 EHNCL-----------------------------------GTELCVPMSRLCNGVQDCMD 100
H C+ G CV + CN QDC D
Sbjct: 138 SHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPD 197
Query: 101 GSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYG 158
GSDE C + C + GC H C G C C + FQL D KTC D DEC
Sbjct: 198 GSDEAG-CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPD 255
Query: 159 TCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQ 218
CSQ+C N G F C C GY + ++CKA + P L+ N + L
Sbjct: 256 ACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTNRHEVRRIDLVKRN 312
Query: 219 VSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLS 278
S + P + A+D A + W + + ++ A M E + I
Sbjct: 313 YSRLIPM-LKNVVALDVEVATNRIYWCDL----SYRKIYSAYMDKASD-PKEQEVLIDEQ 366
Query: 279 LHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVF 338
LH E +A+DW+ + Y+ D + I V +G TL L P+ IA+DP G ++
Sbjct: 367 LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
Query: 339 FTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG 398
++D+G K+E+ ++G +R LV I +P+GITLDL+S+ +YW D+ L + +D+ G
Sbjct: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
Query: 399 KGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT-RV 456
R+T+I + H +G+ VFE+ ++ T+ +N ++ NR N E ++ +
Sbjct: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN------EAIFSANRLNGLEISILAENL 540
Query: 457 DKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NSHKAR-TCRCRSGFSL 512
+ + I+H+ +QPR ACE GGC +CL A +SH + TC C L
Sbjct: 541 NNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCLPAPQISSHSPKYTCACPDTMWL 598
Query: 513 GSDGKSCKKPEHE 525
G D K C + +E
Sbjct: 599 GPDMKRCYRDANE 611
Score = 175 bits (443), Expect = 1e-42
Identities = 89/227 (39%), Positives = 122/227 (53%), Gaps = 17/227 (7%)
Query: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3649 TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRV 3708
T + TC DEFQC + C C+ E DC D SDE C N C +
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG-GCSHICT 223
Query: 3709 CLWIGRQCD--------GTDNCGDGTDEEDCEPPTAHTTHCKDKKEF 3747
L IG +C CG D ++C+ P A + C + K +
Sbjct: 224 DLKIGFECTCPAGFQLLDQKTCG---DIDECKDPDACSQICVNYKGY 267
Score = 171 bits (434), Expect = 1e-41
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 257 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 314
Query: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 315 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 372
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 373 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 432
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 433 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 491
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 492 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 548
Query: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 549 FHELKQPRAPDACELSVQPNGGCEYLCL 576
Score = 166 bits (419), Expect = 6e-40
Identities = 116/376 (30%), Positives = 187/376 (49%), Gaps = 33/376 (8%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 249 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 305
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 306 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 362
Query: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 419
Query: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 420 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 472
Query: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 473 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 530
Query: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 531 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589
Query: 827 CACAEDQVLDADGVTC 842
CAC + L D C
Sbjct: 590 CACPDTMWLGPDMKRC 605
Score = 162 bits (411), Expect = 5e-39
Identities = 90/248 (36%), Positives = 120/248 (48%), Gaps = 37/248 (14%)
Query: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
Query: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
Query: 946 GRCIPISWTCDLDDDCGDRSDESASCA--YPTCFPLTQFTCNNGRCININWRCDNDNDCG 1003
+C+P SW CD + DC +DE A CA TC +F C +G C+ C+ + DC
Sbjct: 139 HKCVPASWRCDGEKDCEGGADE-AGCATSLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCP 196
Query: 1004 DNSDEA--------------GCSHSCSSTQF----KCNSGRCIPEHWTCDGDNDCGDYSD 1045
D SDEA GCSH C+ + C +G + + TC ++C D D
Sbjct: 197 DGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PD 255
Query: 1046 ETHANCTN 1053
C N
Sbjct: 256 ACSQICVN 263
Score = 149 bits (377), Expect = 5e-35
Identities = 89/260 (34%), Positives = 129/260 (49%), Gaps = 33/260 (12%)
Query: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 3430 IFRCNGQDNCGDGEDERDCPEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 3487
+RC+G+ +C G DE C TC ++FQC C+ + C+++ DC DGSDE A
Sbjct: 145 SWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDE-A 202
Query: 3488 NCTQMTCGVDEFRCKDSGRC--------------IPARWKCDGEDDCGDGSDEPKEECDE 3533
C Q G++E ++G C PA ++ + CGD + +
Sbjct: 203 GCLQ---GLNEC-LHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACS 258
Query: 3534 RTCEPYQ--FRCKNNRCVPG 3551
+ C Y+ F+C+ C PG
Sbjct: 259 QICVNYKGYFKCE---CYPG 275
Score = 145 bits (367), Expect = 7e-34
Identities = 84/237 (35%), Positives = 112/237 (47%), Gaps = 28/237 (11%)
Query: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWV 3472
C QF+C N RCIP ++RC+ D+C D DE DCP+ TCA + F C CI W
Sbjct: 47 CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWK 104
Query: 3473 CDRDNDCVDGSDEP-ANCTQMTCGVDEFRC-KDSGRCIPARWKCDGEDDCGDGSDEPKEE 3530
CD + +C DGSDE A CT+ C ++ C S +C+PA W+CDGE DC G+DE
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3531 CDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAG 3590
TC +F+C + CV C+ + DC D SDE C +E NG C
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGC--- 218
Query: 3591 RWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
H C D +CT C +G + + C +C D +AC
Sbjct: 219 ------SHICTDLKIGFECT---------CPAGFQLLDQKTCGDIDEC---KDPDAC 257
Score = 139 bits (349), Expect = 8e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 257 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 315
Query: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 316 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 371
Query: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 372 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 429
Query: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 430 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
Query: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 490 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 549
Query: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 550 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 592
Score = 129 bits (324), Expect = 7e-29
Identities = 77/242 (31%), Positives = 105/242 (43%), Gaps = 40/242 (16%)
Query: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKC--ENNRC 907
P C +F C N CI ERWKCDG+ +C D SDE+ A C + CP+++ C +++C
Sbjct: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC 141
Query: 908 IPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 967
+P W CDG+ DC DE+ S TC ++F C G C+ C+ + DC D SDE
Sbjct: 142 VPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
Query: 968 SASCAYPTCFPLTQFTCNNGRC------ININWRCD--------NDNDCGD---NSDEAG 1010
A C L + NNG C + I + C + CGD D
Sbjct: 202 -AGCLQ----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDA 256
Query: 1011 CSHSCSSTQ--FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQ 1068
CS C + + FKC C P G D NC A + P T+ +
Sbjct: 257 CSQICVNYKGYFKC---ECYP-----------GYEMDLLTKNCKAAAGKSPSLIFTNRHE 302
Query: 1069 CR 1070
R
Sbjct: 303 VR 304
Score = 129 bits (324), Expect = 7e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 257 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 314
Query: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 315 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 361
Query: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 362 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 415
Query: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 416 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 474
Query: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 475 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 534
Query: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 535 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 591
Query: 2505 C 2505
C
Sbjct: 592 C 592
Score = 102 bits (254), Expect = 9e-21
Identities = 59/174 (33%), Positives = 78/174 (44%), Gaps = 19/174 (10%)
Query: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622
++ C+K QC N RC+ ++ C+ DDC D SDE C K C +F C +G CI
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW 103
Query: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSL------CYAPSWVCDGA 2676
+C+ +C D SDE + T K V P E+ S C SW CDG
Sbjct: 104 KCDGEEECPDGSDESEATCT----------KQVC--PAEKLSCGPTSHKCVPASWRCDGE 151
Query: 2677 NDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC 2730
DC +DE C C + F C G C+ C++E DC G DE C
Sbjct: 152 KDCEGGADEAGC-ATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 90.9 bits (224), Expect = 3e-17
Identities = 71/239 (29%), Positives = 99/239 (41%), Gaps = 39/239 (16%)
Query: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+ +
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS 166
Query: 2643 DCSSYFRLGV-KGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDC-PGVKRPRCPLN- 2699
LG +G FQ + T C C+ DC D SDE C G+ C N
Sbjct: 167 -------LGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLN--ECLHNN 215
Query: 2700 --------------YFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFC--SEAQFECQ 2742
CP+G + TC D+C +D C++ C + F+C+
Sbjct: 216 GGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKCE 271
Score = 86.3 bits (212), Expect = 6e-16
Identities = 50/151 (33%), Positives = 64/151 (42%), Gaps = 16/151 (10%)
Query: 2505 CRGGRILQDDLTCRAVNSSCRAQDEFECA------------NGECINFSLTCDGVPHCKD 2552
CR R + C + DE +C NG CI+ CDG C D
Sbjct: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
Query: 2553 KSDEKPSYCNSRRCKKTFRQC--SNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVG 2608
SDE + C + C C ++ +CV C+G DC G+DE C + C
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD 173
Query: 2609 EFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
EF+C DGTC+ CNQ DC D SDE C
Sbjct: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 58.5 bits (140), Expect = 1e-07
Identities = 54/207 (26%), Positives = 77/207 (37%), Gaps = 28/207 (13%)
Query: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQD-----DLTCRAVNSSCRA 2526
+D + C C ++ C + H H C G D + TC C A
Sbjct: 76 SDEDDCPKKTCADSDFTCDN----GHCIHERWKCDGEEECPDGSDESEATC--TKQVCPA 129
Query: 2527 QDEFECA--NGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLW 2584
+ + C + +C+ S CDG C+ +DE + C+ QC +G CV +
Sbjct: 130 E-KLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKH 188
Query: 2585 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTC--------IGNSSRCN---QFVDCEDA 2633
CN DC DGSDE C + G+ E +G C IG C Q +D +
Sbjct: 189 CNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC 245
Query: 2634 SDEMNCSATDCSSYFRLGVKGVLFQPC 2660
D C D S + KG C
Sbjct: 246 GDIDECKDPDACSQICVNYKGYFKCEC 272
Score = 35.8 bits (81), Expect = 1.00
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 8/86 (9%)
Query: 4323 DGSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCV 4378
DG + C A G + C +C +G CV+ + + +C DG CL +
Sbjct: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208
Query: 4379 GHC-SNGGSCT---MNSKMMPECQCP 4400
C N G C+ + K+ EC CP
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCP 234
Score = 34.3 bits (77), Expect = 2.9
Identities = 28/97 (28%), Positives = 37/97 (38%), Gaps = 21/97 (21%)
Query: 4156 CEWLCLLSPSGPVCTCPNG-KRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNA 4214
C +C G CTCP G + LD TC + + P C+ C N F
Sbjct: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDI------DECKDPDACSQICVNYKGYF--- 268
Query: 4215 RRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPS 4251
KC C P Y E+D ++C+ SPS
Sbjct: 269 ----KCECYPGY-----EMDLLTKNCK--AAAGKSPS 294
Score = 33.1 bits (74), Expect = 6.5
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
G N+C NNGGCS +C +C C A Q+LD
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 241
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 400 bits (1027), Expect = e-110
Identities = 212/529 (40%), Positives = 299/529 (56%), Gaps = 27/529 (5%)
Query: 2818 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWE 2877
C+ +F C+N +CIP + CD D DC D SDE +C TC S+F C NG C+ R W+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHCIHER-WK 104
Query: 2878 CDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLC--SSGRCVAEALLCNGQDDCGDSSD 2935
CDGE +C D SDE+ CT Q C A + C +S +CV + C+G+ DC +D
Sbjct: 105 CDGEEECPDGSDESEAT--CTKQV--CPAE-KLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 2936 ERGCH--INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCS 2993
E GC +NECL GCS C DLKIGF+C C GF+L D +TC D+DEC CS
Sbjct: 160 EAGCATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACS 217
Query: 2994 QRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLK 3053
Q C+N G +KC C GY +CKA + P LIF NR+ +R+++L NY+ L
Sbjct: 218 QICVNYKGYFKCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI 276
Query: 3054 QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQVLHRTGLSNPDGLAVDW 3111
L N VALD + IYW D++ + M + +VL L +P+GLAVDW
Sbjct: 277 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 336
Query: 3112 VGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIG 3171
V ++YW D G TI V+ ++G R L S L EPRA+ VD G++YW+DWGD + I
Sbjct: 337 VHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIE 396
Query: 3172 RIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD- 3230
+ G++G R +V I WPNG+TLD +++R+YW D++ + G NR ++S
Sbjct: 397 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 456
Query: 3231 -IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDV 3289
+ H F + +FED V+WTD E ++I A++ G ++L L+ P D+ +FH L+QP
Sbjct: 457 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 516
Query: 3290 PNHPCKVN---NGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTC 3330
P+ C+++ NGGC LCL +P + CACP +LG D + C
Sbjct: 517 PD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 375 bits (962), Expect = e-103
Identities = 198/533 (37%), Positives = 287/533 (53%), Gaps = 21/533 (3%)
Query: 1058 PPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
P C D+FQCR + CIP WRCD D DC+D SDE C T C S F C D+
Sbjct: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKT--CADS-DFTC-DNGH 97
Query: 1118 CISKAWVCDGDNDCEDNSDEEN--CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDG 1175
CI + W CDG+ +C D SDE C C C + C+P CDG DC G
Sbjct: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
Query: 1176 SDEGELC---DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK 1232
+DE ++C NNGGCSH C+ G C+CP G +L D TC C
Sbjct: 158 ADEAGCATWLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDA 215
Query: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVL 1292
CSQ C K KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L
Sbjct: 216 CSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL 275
Query: 1293 VPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVD 1352
+P L+N +ALD ++ + +YW D+ KIY + EV+I L +PEGLAVD
Sbjct: 276 IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
Query: 1353 WIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPR 1412
W+ +IYW +S I VA +DG R TL + ++ PRAIA+DP G ++W+DW +
Sbjct: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAK 394
Query: 1413 IEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVL 1472
IE + ++G R+T+ + WPNG+T+D L +R+ W+D++ + S + G ++
Sbjct: 395 IEKSGLNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 452
Query: 1473 RGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSR 1532
+FLSHPF + ++ +V+WTD + AN+ G ++++ P D+ ++H +
Sbjct: 453 SSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK 512
Query: 1533 QPMAPNPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
QP AP+ CE + G C +LCL +++ +CACP M L D CY
Sbjct: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
Score = 308 bits (789), Expect = 8e-83
Identities = 193/556 (34%), Positives = 277/556 (49%), Gaps = 47/556 (8%)
Query: 3652 RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLW 3711
+ C D+FQC N C P W+CD +DDC D+SDE ++C + C + F C N C+
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTCADS-DFTCDNGH-CIH 100
Query: 3712 IGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLC--RNQRCLSSSLRCNMFDDCGD 3769
+CDG + C DG+DE + T C +K C + +C+ +S RC+ DC
Sbjct: 101 ERWKCDGEEECPDGSDESEA---TCTKQVCPAEK-LSCGPTSHKCVPASWRCDGEKDCEG 156
Query: 3770 GSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECL 3829
G+DE C+ L C N C C + C C +GF + Q C DI+EC
Sbjct: 157 GADEAGCAT--WLNECLHNNGGCSHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECK 211
Query: 3830 RFGTCSQLCNNTKGGHLCSCARNF---MKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHP 3886
CSQ+C N KG C C + + T N CKA + L + +E+R +
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRI--DLV 268
Query: 3887 HSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQID 3946
Y + ++V A+DV V R+YW + +SYR + A S+ +++
Sbjct: 269 KRNYSRLIPMLKNVV--ALDVEVATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV- 320
Query: 3947 RGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI 4006
L L P G+A+DWV ++YWTDSG I VA + G R+TL S + EP AI
Sbjct: 321 -----LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAI 375
Query: 4007 VVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKL 4066
VDPLRG MYWSDWG+ KIE + ++G R+TLV DNI+WP G+ +D ++RLYW D+KL
Sbjct: 376 AVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 435
Query: 4067 SVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4126
+ SI +G + S LSHPF I VFED ++ N +F ++ + L
Sbjct: 436 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 495
Query: 4127 TGGLSHASDVVLYHQHKQPEVTNPCD-----RKKCEWLCLLSPS----GP--VCTCPNGK 4175
L++ D+V++H+ KQP + C+ CE+LCL +P P C CP+
Sbjct: 496 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 555
Query: 4176 RL--DNGTCVPVPSPT 4189
L D C P T
Sbjct: 556 WLGPDMKRCYRAPQST 571
Score = 258 bits (660), Expect = 7e-68
Identities = 168/512 (32%), Positives = 247/512 (48%), Gaps = 41/512 (8%)
Query: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-----EICPQSKAQRCQPN 75
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
Query: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTC 133
H C VP S C+G +DC G+DE C C + GC H C G C
Sbjct: 138 SHKC------VPASWRCDGEKDCEGGADEAG-CATWLNECLHNNGGCSHICTDLKIGFEC 190
Query: 134 YCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
C + FQL D KTC D DEC CSQ+C N G F C C GY + ++CKA
Sbjct: 191 TCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA-- 247
Query: 194 PVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQ 253
+ P L+ N + L S + P + A+D A + W + +
Sbjct: 248 -AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SY 301
Query: 254 TQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDT 313
++ A M E + I LH E +A+DW+ + Y+ D + I V +G
Sbjct: 302 RKIYSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR 360
Query: 314 CVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGIT 373
TL L P+ IA+DP G ++++D+G K+E+ ++G +R LV I +P+GIT
Sbjct: 361 RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGIT 420
Query: 374 LDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNAN 432
LDL+S+ +YW D+ L + +D+ G R+T+I + H +G+ VFE+ ++ T+ +N
Sbjct: 421 LDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN-- 478
Query: 433 AQQKTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
++ NR N E ++ ++ + I+H+ +QPR ACE GGC
Sbjct: 479 ----EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEY 532
Query: 492 ICLLA---NSHKAR-TCRCRSGFSLGSDGKSC 519
+CL A +SH + TC C LG D K C
Sbjct: 533 LCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 171 bits (434), Expect = 1e-41
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 216 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 273
Query: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 274 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
Query: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
Query: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 450
Query: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 451 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 507
Query: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 508 FHELKQPRAPDACELSVQPNGGCEYLCL 535
Score = 167 bits (422), Expect = 3e-40
Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)
Query: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 208 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 264
Query: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 265 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 321
Query: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 322 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 378
Query: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 379 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 431
Query: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 432 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 489
Query: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 490 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548
Query: 827 CACAEDQVLDADGVTCLANP 846
CAC + L D C P
Sbjct: 549 CACPDTMWLGPDMKRCYRAP 568
Score = 151 bits (381), Expect = 2e-35
Identities = 69/187 (36%), Positives = 107/187 (57%), Gaps = 17/187 (9%)
Query: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 3649 TGVRTCPLDEFQCNNTLCK----------PLAWKCDGEDDCGDNSD-ENPEECARFVCPP 3697
T + C + C++ +C P ++ + CGD + ++P+ C++
Sbjct: 165 TWLNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNY 223
Query: 3698 NRPFRCK 3704
F+C+
Sbjct: 224 KGYFKCE 230
Score = 140 bits (352), Expect = 4e-32
Identities = 86/264 (32%), Positives = 115/264 (43%), Gaps = 52/264 (19%)
Query: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
Query: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
Query: 946 GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRC------ININWRCD-- 997
+C+P SW CD + DC +DE+ + L + NNG C + I + C
Sbjct: 139 HKCVPASWRCDGEKDCEGGADEAGCATW-----LNECLHNNGGCSHICTDLKIGFECTCP 193
Query: 998 ------NDNDCGD---NSDEAGCSHSCSSTQ--FKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
+ CGD D CS C + + FKC C P G D
Sbjct: 194 AGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC---ECYP-----------GYEMDL 239
Query: 1047 THANCTNQATRPPGGCHTDEFQCR 1070
NC A + P T+ + R
Sbjct: 240 LTKNCKAAAGKSPSLIFTNRHEVR 263
Score = 139 bits (349), Expect = 8e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 216 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 274
Query: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 275 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
Query: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 331 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 388
Query: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 389 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 448
Query: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 449 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 508
Query: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 509 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 551
Score = 130 bits (326), Expect = 4e-29
Identities = 59/140 (42%), Positives = 82/140 (58%), Gaps = 7/140 (5%)
Query: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCI 3508
P C +QFQC +RCIP VW CD D+DC+D SDE +C + TC +F C D+G CI
Sbjct: 43 PAKDCEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTC-DNGHCI 99
Query: 3509 PARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSD 3566
RWKCDGE++C DGSDE + C ++ C + C +++CVP W+CD + DC +D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 3567 EESCTP--RPCSESEFSCAN 3584
E C C + C++
Sbjct: 160 EAGCATWLNECLHNNGGCSH 179
Score = 129 bits (324), Expect = 7e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 216 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 273
Query: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 274 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 320
Query: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 321 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 374
Query: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 375 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 433
Query: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 434 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 493
Query: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 494 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 550
Query: 2505 C 2505
C
Sbjct: 551 C 551
Score = 126 bits (316), Expect = 6e-28
Identities = 58/128 (45%), Positives = 76/128 (59%), Gaps = 7/128 (5%)
Query: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCD 2754
C + F C + RCIP W CD++DDC DE C K C+++ F C N CI ++W CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2755 GSDDCGDGSDEA-AHCEGKTCGPSSFSC-PGTHVCVPERWLCDGDKDCADGADESIAA-- 2810
G ++C DGSDE+ A C + C SC P +H CVP W CDG+KDC GADE+ A
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
Query: 2811 --GCLYNS 2816
CL+N+
Sbjct: 167 LNECLHNN 174
Score = 124 bits (311), Expect = 2e-27
Identities = 76/245 (31%), Positives = 112/245 (45%), Gaps = 44/245 (17%)
Query: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
Query: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN- 3488
+RC+G+ +C G DE C W+ N+C+ + ++
Sbjct: 145 SWRCDGEKDCEGGADEAGC--------------------ATWL----NECLHNNGGCSHI 180
Query: 3489 CTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ--FRCKNN 3546
CT + G F C PA ++ + CGD + + + C Y+ F+C+
Sbjct: 181 CTDLKIG---FEC-----TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE-- 230
Query: 3547 RCVPG 3551
C PG
Sbjct: 231 -CYPG 234
Score = 84.3 bits (207), Expect = 2e-15
Identities = 60/202 (29%), Positives = 84/202 (41%), Gaps = 37/202 (18%)
Query: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622
++ C+K QC N RC+ ++ C+ DDC D SDE C K C +F C +G CI
Sbjct: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW 103
Query: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSL------CYAPSWVCDGA 2676
+C+ +C D SDE + T K V P E+ S C SW CDG
Sbjct: 104 KCDGEEECPDGSDESEATCT----------KQVC--PAEKLSCGPTSHKCVPASWRCDGE 151
Query: 2677 NDCGDYSDERDCP-----------GVKRPRCPLNY---FACPSGRCIPMSWTCDKEDDCE 2722
DC +DE C G L CP+G + TC D+C
Sbjct: 152 KDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC- 210
Query: 2723 HGEDETHCNKFC--SEAQFECQ 2742
+D C++ C + F+C+
Sbjct: 211 --KDPDACSQICVNYKGYFKCE 230
Score = 79.0 bits (193), Expect = 1e-13
Identities = 41/118 (34%), Positives = 55/118 (46%), Gaps = 6/118 (5%)
Query: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Score = 62.8 bits (151), Expect = 8e-09
Identities = 44/148 (29%), Positives = 58/148 (39%), Gaps = 16/148 (10%)
Query: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC--SNGRCVSNML 2583
A +F C NG CI+ CDG C D SDE + C + C C ++ +CV
Sbjct: 87 ADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW 146
Query: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTC--------IGNSSRCN---QFVDCED 2632
C+G DC G+DE C A + E +G C IG C Q +D +
Sbjct: 147 RCDGEKDCEGGADEAGC---ATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKT 203
Query: 2633 ASDEMNCSATDCSSYFRLGVKGVLFQPC 2660
D C D S + KG C
Sbjct: 204 CGDIDECKDPDACSQICVNYKGYFKCEC 231
Score = 35.8 bits (81), Expect = 1.00
Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538
L+ C NNGGC +C G C+C G L D TC ++ C+ D + C+
Sbjct: 167 LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 221
Query: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565
N+ C+ P +CK + + PS + R
Sbjct: 222 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 259
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 271 bits (693), Expect = 1e-71
Identities = 194/629 (30%), Positives = 279/629 (44%), Gaps = 99/629 (15%)
Query: 2865 CANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLC 2924
CA G LS + C+ N+C A N CT S C G +
Sbjct: 341 CAEGYALSRDRKYCEDVNEC------AFWNHGCTLGCKNTPGSYYCTCPVGFVLLP---- 390
Query: 2925 NGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVD 2984
D + CH R +S CS DC G C C G L+ DG+TC+
Sbjct: 391 ----------DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
Query: 2985 ECST--TFPCSQRCINTHG-SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRK 3041
CS+ CSQ C+ S++C C GY + D SC A + +PFL+FAN +R
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQL-DEKSC-AASGPQPFLLFANSQDIRH 495
Query: 3042 LNLDGSNY-TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTG 3100
++ DG++Y TLL Q + ALD D E IY+ + I R +++GS + L G
Sbjct: 496 MHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK--WIERANMDGSQRERLIEEG 553
Query: 3101 LSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLY 3160
+ P+GLAVDW+G YW D+G+ I S LNG ++ + +PR + V L+
Sbjct: 554 VDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
Query: 3161 WTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDG 3220
WTD G + I + G R VI + + WP+G+T+D++T+++YW DA++ IE A+LDG
Sbjct: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
Query: 3221 SNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHV 3280
S R + D+ H FA+ +FEDYV+++DW S+ R +K TG ++ L ++ +P L V
Sbjct: 674 SKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVV 733
Query: 3281 FHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVS-------- 3332
H L +P PC NGGC ++C G C+C F SDG+TC++
Sbjct: 734 VHPLAKPGA--DPCLYQNGGCEHICKKRLGTAW-CSCREGFMKASDGKTCLALDGHQLLA 790
Query: 3333 ------------------------NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPD 3368
N T SQ + + + +DDC P
Sbjct: 791 GGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMV------SDQDDCA-----PVG 839
Query: 3369 CPEF-KC----RPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNT 3423
C + +C QC G GD + DE + VC P+ KC NT
Sbjct: 840 CSMYARCISEGEDATCQCLKGFA--------GDGKLCSDIDECEMGVPVCPPASSKCINT 891
Query: 3424 N-----RCIPGI----FRCNGQDNCGDGE 3443
RC G C D C GE
Sbjct: 892 EGGYVCRCSEGYQGDGIHCLDIDECQLGE 920
Score = 216 bits (551), Expect = 3e-55
Identities = 129/367 (35%), Positives = 195/367 (53%), Gaps = 11/367 (2%)
Query: 1840 IQLDHKGTNPCSV-NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYS 1896
++ D K + CS +NG CSQLC+P S + C C GY L+ +++C G FLL++
Sbjct: 429 LERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFA 488
Query: 1897 VHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1956
+ IR + D D L G + +D + IY+ L I RA D + R
Sbjct: 489 NSQDIRHMHFDGTDYGTLLSQQMG--MVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Query: 1957 EDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVH 2016
E ++ G+ EG+AVDWI YWTD+G +I + LNG ++ + + +PR I VH
Sbjct: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVH 606
Query: 2017 PEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKI 2076
P LFWT+ G PRIE S L G R+V+ + + WP+GI++D+ KLYWCDA+ I
Sbjct: 607 PMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
Query: 2077 ERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRT 2136
E +L+ G R + ++ F+V+VFED++++SD A S+ R +K D V L+
Sbjct: 667 EMANLD-GSKRRRLTQNDVGHPFAVAVFEDYVWFSD--WAMPSVMRVNKRTGKDRVRLQ- 722
Query: 2137 GIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHG-MLAEDGASCR 2195
G ++ + V + + G + C NGGC+ +C R G C+C G M A DG +C
Sbjct: 723 GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR-LGTAWCSCREGFMKASDGKTCL 781
Query: 2196 EYAGYLL 2202
G+ L
Sbjct: 782 ALDGHQL 788
Score = 198 bits (503), Expect = 1e-49
Identities = 145/461 (31%), Positives = 217/461 (47%), Gaps = 47/461 (10%)
Query: 1131 CEDNSD----EENCESLACR--PPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQ 1184
CED ++ C +L C+ P S+ C L PD G+ C Q
Sbjct: 354 CEDVNECAFWNHGC-TLGCKNTPGSYYCTCPVGFVLLPD---------------GKRCHQ 397
Query: 1185 ---CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAK--HLKCSQKC-D 1238
C N CSH+C V EG +C CP G L D TC S C+ + CSQ C
Sbjct: 398 LVSCPRNVSECSHDC-VLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVP 453
Query: 1239 QNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRN 1298
+ S +C C+ G+ L+ D +SC + P +PF++F+N +IR + DY L+
Sbjct: 454 LSPVSWECDCFPGYDLQLDEKSCAASGP-QPFLLFANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 1299 TI-ALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGN 1357
+ ALD ++ +Y+ I R + +G+ E +I+ G+ PEGLAVDWI
Sbjct: 513 MVYALDHDPVENKIYFAHTALKWIERANM--DGSQR--ERLIEEGVDVPEGLAVDWIGRR 568
Query: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
YW + I + L+G + +I PR IA+ P LFWTD + PRIE++S
Sbjct: 569 FYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGIN-PRIESSS 627
Query: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEF 1477
+ G GR + + WP+G+T+D+L ++ W DA+ I A DGS + +
Sbjct: 628 LQGLGRLVI--ASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND-- 683
Query: 1478 LSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAP 1537
+ HPFAV ++ V+++DW ++ + NK TG + +Q + +P L V HP +P A
Sbjct: 684 VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGAD 743
Query: 1538 NPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTC 1578
NGG C H+C T C+C D TC
Sbjct: 744 PCLYQNGG---CEHICKKRLG-TAWCSCREGFMKASDGKTC 780
Score = 176 bits (447), Expect = 4e-43
Identities = 127/422 (30%), Positives = 189/422 (44%), Gaps = 38/422 (9%)
Query: 104 EGPHCRELQGNCSR--LGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSV--YGT 159
+G C +L +C R C H CV T +GP C+C L+ DGKTC CS G
Sbjct: 391 DGKRCHQLV-SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---CSSPDNGG 446
Query: 160 CSQLCTNTDG-SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQ 218
CSQLC S+ C C GY LQ D +SC A P LL ANSQ+I + G
Sbjct: 447 CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQ----PFLLFANSQDIRHMHFDGTD 502
Query: 219 VSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLS 278
T+ A+D + + H T LK + G E I +
Sbjct: 503 YGTLLSQQMGMVYALDHDPVENKIYFAH-------TALKWIERANMDGSQRERLIEEGVD 555
Query: 279 LHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVF 338
+ E +A+DW+ FY+ D I + NG + + P+GIA+ P ++F
Sbjct: 556 VP--EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
Query: 339 FTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG 398
+TD G P++E + G R + S +++P GIT+D ++ +YW DA IE+ + +G
Sbjct: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
Query: 399 KGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN-RFNSTEYQVVTRVD 457
R+ + Q + H + + VFE+Y++ ++ SV+RVN R ++ +
Sbjct: 674 SKRRRLTQND-VGHPFAVAVFEDYVWFSD------WAMPSVMRVNKRTGKDRVRLQGSML 726
Query: 458 KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGK 517
K +L + H +P +N GGC IC C CR GF SDGK
Sbjct: 727 KPSSLVVVHPLAKPGADPCLYQN------GGCEHIC--KKRLGTAWCSCREGFMKASDGK 778
Query: 518 SC 519
+C
Sbjct: 779 TC 780
Score = 171 bits (434), Expect = 1e-41
Identities = 171/737 (23%), Positives = 289/737 (39%), Gaps = 140/737 (18%)
Query: 3781 KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN 3840
+L SC N S C + CV T + C C G C + G CSQLC
Sbjct: 397 QLVSCPRNVSECSHD--CVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDN-GGCSQLCVP 453
Query: 3841 TKG-GHLCSCARNF--MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQG 3896
C C + +C A G + +L+ A+ +IR + F G + G
Sbjct: 454 LSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-ANSQDIRHMHFDGTDYGTLLSQQMG 512
Query: 3897 DESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISG 3956
+ A+D ++Y+ + I ++ ++ R I+ GV
Sbjct: 513 ----MVYALDHDPVENKIYFAHTALKWIERANMD-------GSQRERLIEEGVD------ 555
Query: 3957 LKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMY 4016
+P G+A+DW+ YWTD G+ +I + + G+ K + I +P I V P+ ++
Sbjct: 556 --VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
Query: 4017 WSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNG 4076
W+D G +P+IE++++ G R + ++ WP+G+ +D+ ++LYW DAK SVI L+G
Sbjct: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
Query: 4077 TDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDV 4136
+ ++ + HPF++ VFEDY++ + V +++K V L G + S +
Sbjct: 674 SKR--RRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSL 731
Query: 4137 VLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNG--KRLDNGTCVPVPSPTPPP 4192
V+ H +P +PC CE +C C+C G K D TC+ +
Sbjct: 732 VVVHPLAKPG-ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGH---- 786
Query: 4193 DAPRPGTCNLQCFNGGSCFLNARRQP-KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPS 4251
Q GG L + P + R + D Q + S
Sbjct: 787 ----------QLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQ------HMLVAEIMVS 830
Query: 4252 GMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGY 4311
C P G C+ + C +++G C+CL GF GD
Sbjct: 831 DQDDC-APVG--------------CSMYARC-ISEGEDATCQCLKGFAGD-------GKL 867
Query: 4312 CENFGTCQMA-------------ADGSRQCRCTAYFEGS--RC-EVNKCS----RCLEGA 4351
C + C+M +G CRC+ ++G C ++++C C E A
Sbjct: 868 CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENA 927
Query: 4352 CVVNKQSGDVTCNCTDGRVAPSCLTCV-----------------------------GHCS 4382
N + G TC C GR++ L C G+C
Sbjct: 928 SCTNTEGG-YTCMCA-GRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCL 985
Query: 4383 NGGSCT-MNSKMMPECQCPPHMTGPRCE---------EHV-FSQQQPGHIASILIPLLLL 4431
+ G C + + C C G RC+ H QQQ + ++ + +L++
Sbjct: 986 HDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVM 1045
Query: 4432 LLLVLVAGVVFWYKRRV 4448
LLL+ + G ++ +++
Sbjct: 1046 LLLLSLWGAHYYRTQKL 1062
Score = 158 bits (399), Expect = 1e-37
Identities = 105/358 (29%), Positives = 176/358 (49%), Gaps = 20/358 (5%)
Query: 487 GGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAK 546
GGCS +C+ S + C C G+ L D KSC + FL++ + IR M
Sbjct: 445 GGCSQLCVPL-SPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQD--IRHMHFDGT 501
Query: 547 VPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEG 606
D + + + ALD IYFA T I R +DG++RE ++++G+ EG
Sbjct: 502 --DYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
Query: 607 VAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTD 666
+AVDW+G YWTD G + R + + K + + ++ PR I V P+ ++WTD
Sbjct: 560 LAVDWIGRRFYWTDRGKS---LIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTD 616
Query: 667 WEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETI 726
+P R+E + + G R + + S ++WP+G+++D +LYW DA IE
Sbjct: 617 TGINP------RIESSSLQGLGR-LVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMA 669
Query: 727 LLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSER 786
L+G+ R+ + + ++ H F + +Y++++++ SV R+ + G V L S
Sbjct: 670 NLDGSKRRRLTQN-DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTG--KDRVRLQGSML 726
Query: 787 PPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLA 844
P + ++ + G + C NGGC +C G+ C+C E + +DG TCLA
Sbjct: 727 KPSSLVVVHPLAKP--GADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLA 782
Score = 144 bits (364), Expect = 2e-33
Identities = 100/352 (28%), Positives = 161/352 (45%), Gaps = 28/352 (7%)
Query: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF--KKFLLYARQMEIRGVDLDAPYYN 1604
G CS LC+ + C C L D +C + FLL+A +IR + D Y
Sbjct: 445 GGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYG 504
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
++S + V LD+D E ++Y++ + I+RA ++G+ E ++ + GLA
Sbjct: 505 TLLS---QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 1665 VDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD--- 1720
VDW+ R +WT D K I + L+G + + + QP G+ VHP+ +L+WTD
Sbjct: 562 VDWIGRRFYWT--DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
Query: 1721 GDNISMANMDGSNRTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVI 1779
I +++ G R ++ S P G+ IDF KLYW + I NLDGS +
Sbjct: 620 NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRL 679
Query: 1780 DAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV-----VLRNSTTLVMHMK 1834
++ +G A+A+ D +W++D + +K G V +L+ S+ +V+H
Sbjct: 680 --TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVH-- 735
Query: 1835 VYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQAC 1886
L G +PC NG C +C T C C G+ S + C
Sbjct: 736 ------PLAKPGADPCLYQNGGCEHICKKRLGTA-WCSCREGFMKASDGKTC 780
Score = 134 bits (338), Expect = 2e-30
Identities = 150/579 (25%), Positives = 231/579 (39%), Gaps = 57/579 (9%)
Query: 2113 RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLY 2172
R H S R + + D V G + V RD + + + NGGC QLC+
Sbjct: 394 RCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVP 453
Query: 2173 RGRGQRACACAHGM-LAEDGASCREYAG--YLLYSERTILKSIHLSDERNLNAPVQPFED 2229
C C G L D SC +LL++ ++ +H D + +
Sbjct: 454 LSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHF-DGTDYGTLLS---- 508
Query: 2230 PEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGL 2288
+ M V AL D N+I+F+ I++ N DGS+R ++E V EGL
Sbjct: 509 -QQMGMVYALDHD-------PVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGL 560
Query: 2289 AYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFW 2348
A YWT S I R ++ +R +IT PR + +FW
Sbjct: 561 AVDWIGRRFYWTDRGKSLIGRSDLNG------KRSKIITKENISQPRGIAVHPMAKRLFW 614
Query: 2349 TNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDG 2408
T+ +P I ++L G L + D+ P+G+ ID +KLY+ DA IE DG
Sbjct: 615 TDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
Query: 2409 SHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGII 2468
S R + +++ HPF +AV+ ++++++DW +V R NK G + L+ + +P ++
Sbjct: 674 SKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSM-LKPSSLV 732
Query: 2469 AVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRI-LQDDLTCRAVNS-SCRA 2526
V + PC NGGC+ +C G CSCR G + D TC A++ A
Sbjct: 733 -VVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTCLALDGHQLLA 790
Query: 2527 QDEFECANGECINFSLTCDGVPH---------------CKDKSDEKPSYCNS-RRC---- 2566
E + N L+ V D+ D P C+ RC
Sbjct: 791 GGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEG 850
Query: 2567 KKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTAC----GVGEFRCRDGTCIGNSS 2622
+ QC G L C+ D+C G P + C G RC +G G+
Sbjct: 851 EDATCQCLKGFAGDGKL-CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG-YQGDGI 908
Query: 2623 RCNQFVDCE--DASDEMNCSATDCSSYFRLGVKGVLFQP 2659
C +C+ + S N S T+ + G L +P
Sbjct: 909 HCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEP 947
Score = 127 bits (319), Expect = 3e-28
Identities = 90/325 (27%), Positives = 159/325 (48%), Gaps = 29/325 (8%)
Query: 3029 PFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL 3088
PFLIF++ + +++ +G+NY L +V +DF Y E+ IYW D+ Q +++R+ L
Sbjct: 46 PFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQ--LLQRVFL 103
Query: 3089 NGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPR 3148
NGS + + N G+A++W+ + W ++ I V+ + G +L+S+ L+ P
Sbjct: 104 NGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPA 161
Query: 3149 ALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT--KITWPNGLTLDYVTERIYW- 3205
+ VD +++W+ SL R +DG +++T KIT ++LD + +R++W
Sbjct: 162 NVAVDPVERFIFWSSEVAGSLY-RADLDGVGVKALLETSEKIT---AVSLDVLDKRLFWI 217
Query: 3206 ---ADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
+ I DG + H+ ++FA++LF D ++++ W+ K+I A+K TG
Sbjct: 218 QYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
Query: 3263 TNKTLLISTLHRPM----DLHVFHALRQPDVPNHP-------CKVNNGGCSNLCLLSPGG 3311
K ++ LH +L V H L QP + CK+ G CS+
Sbjct: 278 --KDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQ 335
Query: 3312 GHKCACPTNFYLGSDGRTC--VSNC 3334
H C C + L D + C V+ C
Sbjct: 336 SHLCMCAEGYALSRDRKYCEDVNEC 360
Score = 112 bits (279), Expect = 1e-23
Identities = 74/343 (21%), Positives = 153/343 (44%), Gaps = 29/343 (8%)
Query: 1564 ACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYD 1623
+CP N+TC FL+++ I +D + Y + V D ++D+
Sbjct: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL----VVDAGVSVIMDFH 82
Query: 1624 AREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQ 1683
E+R+YW D+ Q ++R F+NG+ E V + + N G+A++W++ + W+ + +
Sbjct: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWS--NQQEGI 139
Query: 1684 INVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNRTLLFSGQ 1741
I V + G+ + ++ L+ P + V P+ ++W+ ++ A++DG L
Sbjct: 140 ITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETS 199
Query: 1742 KGPVGLAIDFPESKLYWI----SSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGD 1797
+ +++D + +L+WI N I C+ DG + + + A+++ GD
Sbjct: 200 EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI--SKHPTQHNLFAMSLFGD 257
Query: 1798 KLWWADQVSEKMGTCSKADGSGSVVLRNSTTLV-----------MHMKVYDESIQLDHKG 1846
+++++ + + +K G V + ++ V K D++ + + K
Sbjct: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQK- 316
Query: 1847 TNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGV 1889
C + G+CS + CMC GY+L ++ CE V
Sbjct: 317 --LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
Score = 108 bits (271), Expect = 9e-23
Identities = 90/344 (26%), Positives = 159/344 (46%), Gaps = 28/344 (8%)
Query: 1247 SCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHL 1306
SC EG + +C + P PF+IFS+ + I RID +Y LV ++ +DFH
Sbjct: 27 SCPEGTLAGNGNSTC--VGP-APFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHY 83
Query: 1307 SQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLD 1366
++ +YW D+ + R L NG+ I+ ++ G+A++WI + W
Sbjct: 84 NEKRIYWVDLERQLLQRVFL--NGSRQERVCNIEKNVS---GMAINWINEEVIWSNQQEG 138
Query: 1367 QIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTV 1426
I V + G + +L +++P +A+DP + +FW+ A + A + G G + +
Sbjct: 139 IITVTDMKGN-NSHILLSALKYPANVAVDPVERFIFWSSEVAG--SLYRADLDGVGVKAL 195
Query: 1427 HRETGSGGWPNGLTVDYLEKRILWI----DARSDAIYSARYDGSGHMEVLRGHEFLSHPF 1482
+ +++D L+KR+ WI + + I S YDG G + + + H + F
Sbjct: 196 LETSEK---ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISK-HPTQHNLF 250
Query: 1483 AVTLYGGEVYWTDWRTNTLAKANKWTGHN-VTVVQRTNTQPF-DLQVYHPSRQPMA---- 1536
A++L+G ++++ W+ T+ ANK TG + V + ++ P +L+V HP QP A
Sbjct: 251 AMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDT 310
Query: 1537 --PNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTC 1578
P +G CS ++ C C L +D C
Sbjct: 311 WEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
Score = 85.1 bits (209), Expect = 1e-15
Identities = 79/338 (23%), Positives = 141/338 (41%), Gaps = 23/338 (6%)
Query: 1873 CTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE 1932
C G +G C G FL++S I I + + +V ++V +DFH
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAG---VSVIMDFHYN 84
Query: 1933 NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVA 1992
IYWVD+ + R + + R++ V N V G+A++WI + W++Q +I V
Sbjct: 85 EKRIYWVDLERQLLQRVFLNGS-RQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVT 143
Query: 1993 RLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSIS 2052
+ G+ ++++S L P + V P + ++FW+ + R+ LDG L+ S
Sbjct: 144 DMKGNNSHILLS-ALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS-E 200
Query: 2053 WPNGISVDYQDGKLYWCDARTDKIERIDLE---TGENREVVLSSNNMDMFSVSVFEDFIY 2109
+S+D D +L+W + + G + + ++F++S+F D I+
Sbjct: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260
Query: 2110 WSDRTHANGSIKRGSKDNATDSVPLRTGIG-VQLKDIKVFNRDRQKGT---------NVC 2159
+S T +I +K D V + V L ++KV + Q +C
Sbjct: 261 YS--TWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 2160 AVANGGCQQLCLYRGRGQRACACAHG-MLAEDGASCRE 2196
+ G C + C CA G L+ D C +
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCED 356
Score = 79.3 bits (194), Expect = 8e-14
Identities = 94/396 (23%), Positives = 162/396 (40%), Gaps = 62/396 (15%)
Query: 2254 RIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
RI++ D+ +Q++ +GSR+ + +V G+A + + + W++ IT +
Sbjct: 87 RIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMK 146
Query: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
+ I +S +P +D + +FW++ E S+ RA L G V L+E
Sbjct: 147 GNN-------SHILLSALKYPANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLE 197
Query: 2374 KDIRTPNGLAIDHRAEKLYF----SDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYG 2429
+ +++D ++L++ + + I C+YDG ++ + F ++++G
Sbjct: 198 TSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFG 256
Query: 2430 EHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA---------NDTNSCELS 2480
+ IF++ W + + ANKH G +M + + P+G + V +DT E
Sbjct: 257 DRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQK 316
Query: 2481 PCRINNGGCQD-LCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECA--NGEC 2537
C++ G C +C Q H+ G + +D C VN ECA N C
Sbjct: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVN---------ECAFWNHGC 367
Query: 2538 INFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGR-------CVSNMLWCNGADD 2590
+L C P YC C F +G+ C N+ C + D
Sbjct: 368 ---TLGCKNTP--------GSYYCT---CPVGFVLLPDGKRCHQLVSCPRNVSEC--SHD 411
Query: 2591 CGDGSDEIPCNKTACGVGEFRCRDG-TCIGNSSRCN 2625
C S+ C C G RDG TC G SS N
Sbjct: 412 CVLTSEGPLC---FCPEGSVLERDGKTCSGCSSPDN 444
Score = 77.0 bits (188), Expect = 4e-13
Identities = 109/496 (21%), Positives = 199/496 (40%), Gaps = 75/496 (15%)
Query: 506 CRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIR----GMDMGAKVPDEHMIPIENLMNP 561
C G G+ +C P FL++ G I R G + V D + I
Sbjct: 28 CPEGTLAGNGNSTCVGPAP--FLIFSHGN-SIFRIDTEGTNYEQLVVDAGVSVI------ 78
Query: 562 RALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDD 621
+DFH IY+ D L+ R ++G+ +E + NV G+A++W+ + + W++
Sbjct: 79 --MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQ 135
Query: 622 GPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLER 681
+ I+V ++ ++ + +P + VDP+ +++W+ G L R
Sbjct: 136 -QEGIITVTDMK---GNNSHILLSALKYPANVAVDPVERFIFWS-------SEVAGSLYR 184
Query: 682 AWMDG-SHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLN-GTDRKIVY-- 737
A +DG + + TS+ + +SLD+ RL+W+ + +++ + D V+
Sbjct: 185 ADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHIS 241
Query: 738 EGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDA 797
+ P ++ F + G+ +F++ ++ +++ + G + L S P+ E+++
Sbjct: 242 KHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRIN-LHSSFVPLGELKVVHP 300
Query: 798 QQQQVGTNK--------CRVNNGGCSS-LCLATPGSRQCACAEDQVLDADGVTC------ 842
Q + C++ G CSS +C S C CAE L D C
Sbjct: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC 360
Query: 843 -LANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRF 900
N + PG + C C L + CHQ +CP +
Sbjct: 361 AFWNHGCTLGCKNTPGSYYCT----------CPVGFVLLPDGKR----CHQLVSCPRNVS 406
Query: 901 KCENNRCIPNRW-LCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCI---PISWTCD 956
+C ++ + + LC G+ + TCS + P N S C+ P+SW CD
Sbjct: 407 ECSHDCVLTSEGPLCFCPE--GSVLERDGKTCSGCSSPDN--GGCSQLCVPLSPVSWECD 462
Query: 957 LDDDCGDRSDESASCA 972
+ DE SCA
Sbjct: 463 CFPGYDLQLDEK-SCA 477
Score = 66.6 bits (161), Expect = 5e-10
Identities = 94/418 (22%), Positives = 163/418 (38%), Gaps = 53/418 (12%)
Query: 3905 MDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIA 3964
MD H R+YW + + L + N + N+SG+ A
Sbjct: 79 MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK----------NVSGM------A 122
Query: 3965 IDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHP 4024
I+W+ V W++ +I V MKG N L+S + P + VDP+ ++WS
Sbjct: 123 INWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-EVAG 180
Query: 4025 KIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYW----ADAKLSVIGSIRLNGTDPI 4080
+ A +DG + L++ + + T +++D ++RL+W + S+I S +G
Sbjct: 181 SLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVH 239
Query: 4081 VAADSKRGLSHP-FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV--NLTGGLSHASDVV 4137
+ SK H F++ +F D I+ T+ ++ +K +V NL ++
Sbjct: 240 I---SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELK 296
Query: 4138 LYHQHKQPEVTNPC---DRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDA 4194
+ H QP+ + ++K C+ L + S VC G+ L + C+ D
Sbjct: 297 VVHPLAQPKAEDDTWEPEQKLCK-LRKGNCSSTVC----GQDLQSHLCMCAEGYALSRDR 351
Query: 4195 PRPGTCNLQCFNGGSCFLNARRQP---KCRCQPRYT----GDKC-ELDQCWEHCRNGGTC 4246
N F C L + P C C + G +C +L C +
Sbjct: 352 KYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHD 411
Query: 4247 AASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQP------QCRCLPGF 4298
S P C CP G + + C+G C++ +Q P +C C PG+
Sbjct: 412 CVLTSEGPLCFCPEGSVLER-DGKTCSG-CSSPDNGGCSQLCVPLSPVSWECDCFPGY 467
Score = 63.5 bits (153), Expect = 4e-09
Identities = 84/379 (22%), Positives = 144/379 (37%), Gaps = 47/379 (12%)
Query: 175 CVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMD 234
C EG L N +C V P L+ ++ +I G + + MD
Sbjct: 28 CPEGTLAGNGNSTC------VGPAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVSVIMD 80
Query: 235 FSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNF 294
F Y + + WV + Q L G E NI +V MAI+W+
Sbjct: 81 FHYNEKRIYWVDLERQLLQRVF-------LNGSRQERVCNIE---KNVSGMAINWINEEV 130
Query: 295 YFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMD 354
+ + + I V + G+ LL Y P +A+DP +F++ + R D+D
Sbjct: 131 IWSNQQEGIITVTDMKGNNSHILLSALKY-PANVAVDPVERFIFWSSE-VAGSLYRADLD 188
Query: 355 GQNRTKLVDSKIVFPHGITLDLVSRLVYWA----DAYLDYIEVVDYEGKGRQTIIQGILI 410
G L+++ ++LD++ + ++W + I DY+G G I +
Sbjct: 189 GVGVKALLETSEKIT-AVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQ 246
Query: 411 EHLYGLTVF-ENYLYATNSDN----ANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIY 465
+L+ +++F + Y+T AN ++R+N +S G L +
Sbjct: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPL--------GELKVV 298
Query: 466 HQRRQPRVRSHACENDQYG---KPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKP 522
H QP+ E +Q + G CS + ++ C C G++L D K C+
Sbjct: 299 HPLAQPKAEDDTWEPEQKLCKLRKGNCSST-VCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
Query: 523 EHELFLVYG-----KGRPG 536
F +G K PG
Sbjct: 358 NECAFWNHGCTLGCKNTPG 376
Score = 60.5 bits (145), Expect = 4e-08
Identities = 29/82 (35%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Query: 108 CRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGT-CSQLCTN 166
C+ +GNCS C L C C + L D K C+D +EC+ + C+ C N
Sbjct: 318 CKLRKGNCSSTVCGQD----LQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN 373
Query: 167 TDGSFICGCVEGYLLQPDNRSC 188
T GS+ C C G++L PD + C
Sbjct: 374 TPGSYYCTCPVGFVLLPDGKRC 395
Score = 57.0 bits (136), Expect = 4e-07
Identities = 31/83 (37%), Positives = 40/83 (48%), Gaps = 10/83 (12%)
Query: 112 QGNCSRLGCQHH--CVPTLDGPTCYCNSSFQLQADGKTCKDFDECS----VYGTCSQLCT 165
Q +C+ +GC + C+ + TC C F DGK C D DEC V S C
Sbjct: 832 QDDCAPVGCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCI 889
Query: 166 NTDGSFICGCVEGYLLQPDNRSC 188
NT+G ++C C EGY Q D C
Sbjct: 890 NTEGGYVCRCSEGY--QGDGIHC 910
Score = 48.1 bits (113), Expect = 2e-04
Identities = 33/99 (33%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 2916 RCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGC---SQDCEDLKIGFKCRCRPGF 2971
RC++E Q G + D + C I+EC + C S C + + G+ CRC G+
Sbjct: 845 RCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVCRCSEGY 903
Query: 2972 RLKDDGRTCADVDECST-TFPCSQR--CINTHGSYKCLC 3007
+ DG C D+DEC C + C NT G Y C+C
Sbjct: 904 Q--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
Score = 45.1 bits (105), Expect = 0.002
Identities = 36/132 (27%), Positives = 52/132 (39%), Gaps = 18/132 (13%)
Query: 55 DGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGN 114
D D AP C + + C + +LC+ + +C G P C
Sbjct: 831 DQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGV---PVCPPASSK 887
Query: 115 CSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSV-YGTCSQ--LCTNTDGSF 171
C + T G C C+ +Q DG C D DEC + +C + CTNT+G +
Sbjct: 888 C---------INTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGY 936
Query: 172 ICGCVEGYLLQP 183
C C G L +P
Sbjct: 937 TCMCA-GRLSEP 947
Score = 45.1 bits (105), Expect = 0.002
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 16/104 (15%)
Query: 3761 CNMFDDCGDGSDEEDCSI------DPKLTS----CATNASICGD-EARCVRTEKAAYCAC 3809
C+M+ C ++ C D KL S C +C ++C+ TE C C
Sbjct: 840 CSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRC 899
Query: 3810 RSGFHTVPGQPGCQDINEC-LRFGTCSQ--LCNNTKGGHLCSCA 3850
G+ C DI+EC L +C + C NT+GG+ C CA
Sbjct: 900 SEGYQG--DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCA 941
Score = 43.5 bits (101), Expect = 0.005
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 3774 EDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFG- 3832
ED + +P+ C C C + ++ C C G+ + C+D+NEC +
Sbjct: 307 EDDTWEPEQKLCKLRKGNCSSTV-CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH 365
Query: 3833 TCSQLCNNTKGGHLCSCARNFM 3854
C+ C NT G + C+C F+
Sbjct: 366 GCTLGCKNTPGSYYCTCPVGFV 387
Score = 42.0 bits (97), Expect = 0.014
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 17/87 (19%)
Query: 3771 SDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINEC-L 3829
SD++DC+ C ARC+ + A C C GF C DI+EC +
Sbjct: 830 SDQDDCA-----------PVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEM 876
Query: 3830 RFGTC---SQLCNNTKGGHLCSCARNF 3853
C S C NT+GG++C C+ +
Sbjct: 877 GVPVCPPASSKCINTEGGYVCRCSEGY 903
Score = 34.7 bits (78), Expect = 2.2
Identities = 14/34 (41%), Positives = 16/34 (47%)
Query: 119 GCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFD 152
GC+H C L C C F +DGKTC D
Sbjct: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
Score = 33.5 bits (75), Expect = 5.0
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 20/114 (17%)
Query: 815 SSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACA-NSRCIQER--W 871
SS C+ T G C C+E DG+ CL +CQ GE +C N+ C +
Sbjct: 885 SSKCINTEGGYVCRCSEG--YQGDGIHCL------DIDECQLGEHSCGENASCTNTEGGY 936
Query: 872 KCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED 925
C C E +C T P + +++ + N D++C S D
Sbjct: 937 TC----MCAGRLSEPGLICPDSTPPPHLREDDHHYSVRN-----SDSECPLSHD 981
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 203 bits (516), Expect = 4e-51
Identities = 150/476 (31%), Positives = 212/476 (44%), Gaps = 86/476 (18%)
Query: 3375 RPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCN 3434
R F C++GIC C+G NDC D SDEA+C+ C + F C +T +C+ C+
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHC-HTGKCLNYSLVCD 326
Query: 3435 GQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTC 3494
G D+CGD DE++C C P RCI WVCD D+DCVD SDE NC+ +
Sbjct: 327 GYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDE-VNCSCHSQ 382
Query: 3495 GVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVP---G 3551
G+ E R +G+CIP+ ++CDG++DC DGSDE + +C+ RC N C+ G
Sbjct: 383 GLVECR---NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGG 439
Query: 3552 RWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGR---------W---------- 3592
CD +N + S E T C ++ + G W
Sbjct: 440 SSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQ 499
Query: 3593 -----------------KCDGDHDCADGSDEKDCTPRCDMDQFQCKSG-HCIPLRWRCDA 3634
KCD + G C C+ + +C+S + L+W
Sbjct: 500 TNCYKYLMFFSCTILVPKCDVN----TGEHIPPCRALCEHSKERCESVLGIVGLQW--PE 553
Query: 3635 DADCM----DGSDEEAC---GTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP 3687
D DC + SD + C V C F+C + C + +CDG+ DC D+SDE
Sbjct: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDE-- 611
Query: 3688 EECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEF 3747
E C C + C +++ CL CDG +C D DE++C + C+D E
Sbjct: 612 ENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC-------SFCQD-DEL 660
Query: 3748 LCRNQRCLSSSLRCNMFDDCGDGSDEEDC---SIDPKLTS------CATNASICGD 3794
C N C+S L C+ DC D SDE DC SI+ +S AT +C D
Sbjct: 661 ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCAD 716
Score = 172 bits (437), Expect = 5e-42
Identities = 142/515 (27%), Positives = 201/515 (39%), Gaps = 126/515 (24%)
Query: 807 CRVNNGGCSSLC----LATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQ--CQPGE-F 859
C GC S+ + P +C+ +Q ++ +P Q C GE F
Sbjct: 216 CEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENF 275
Query: 860 ACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDND 919
CA+ CI + +C+G NDC D SDEA C ++ F C +C+ +CDG +D
Sbjct: 276 LCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENL-----FHCHTGKCLNYSLVCDGYDD 330
Query: 920 CGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPL 979
CG+ DE N C+ P + C GRCI + W CD D DC D+SDE +C +C
Sbjct: 331 CGDLSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDE-VNC---SCHSQ 382
Query: 980 TQFTCNNGRCININWRCDNDNDCGDNSDEAGCS---HSCSSTQFKCNSGRCIPE---HWT 1033
C NG+CI ++CD D DC D SDE CS SC +C C+
Sbjct: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSL 442
Query: 1034 CDGDNDCGD----------------YSDETHANCTNQATR-------------------- 1057
CD +N + Y+ ++ N T+
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
Query: 1058 -------------PPGGCHTDEFQCRLDGLCIPLRWRCDG-----------DTDCM---- 1089
P +T E LC + RC+ DTDC
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPE 562
Query: 1090 DSSDEKSC---EGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACR 1146
++SD ++C + C PS F C+ S +C+ + CDG DC+D+SDEENC C+
Sbjct: 563 ENSDNQTCLMPDEYVEECSPS-HFKCR-SGQCVLASRRCDGQADCDDDSDEENC---GCK 617
Query: 1147 PPS-HPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIV 1205
C +N CL +CDG DC D DE NCS + +
Sbjct: 618 ERDLWECPSNKQ-CLKHTVICDGFPDCPDYMDE---------------KNCSFCQDDELE 661
Query: 1206 CSCPLGMELGPDNHTCQIQS-YCAKHLKCSQKCDQ 1239
C+ NH C + +C CS D+
Sbjct: 662 CA----------NHACVSRDLWCDGEADCSDSSDE 686
Score = 166 bits (420), Expect = 5e-40
Identities = 137/442 (30%), Positives = 183/442 (41%), Gaps = 76/442 (17%)
Query: 3339 FVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDND 3398
F+C + CIP +C+ +DC D SDE C F C TG C N + +CDG +D
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEA----HCNCSENLFHCHTGKCLNYSLVCDGYDD 330
Query: 3399 CQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQF 3458
C D SDE NCD C P+ RCI + C+G +C D DE +C +C
Sbjct: 331 CGDLSDEQNCD---CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC---SCHSQGL 384
Query: 3459 QCSITKRCIPRVWVCDRDNDCVDGSDEPANCT--QMTCGVDEFRCKDSGRCIPARWKCDG 3516
+CIP + CD D DC DGSDE NC+ Q +C + RC + P C G
Sbjct: 385 VECRNGQCIPSTFQCDGDEDCKDGSDE-ENCSVIQTSCQEGDQRCLYN----PCLDSCGG 439
Query: 3517 EDDCG-DGSDEPKEECDERTCE------------PYQFRCKNNRCVPGRWQCD-----YD 3558
C + S +C+ T E P F + + W+
Sbjct: 440 SSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQ 499
Query: 3559 NDCGDNSDEESCT---PR--------------PCSESEFSCANGRCIAG-RWKCDGDHDC 3600
+C SCT P+ C S+ C + I G +W D DC
Sbjct: 500 TNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQW--PEDTDC 557
Query: 3601 A----DGSDEKDC------TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTG 3650
+ + SD + C C F+C+SG C+ RCD ADC D SDEE CG
Sbjct: 558 SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK 617
Query: 3651 VRTCPLDEFQC-NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVC 3709
R D ++C +N C CDG DC D DE + C+ C + C N C
Sbjct: 618 ER----DLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNCS--FCQDDE-LECAN-HAC 667
Query: 3710 LWIGRQCDGTDNCGDGTDEEDC 3731
+ CDG +C D +DE DC
Sbjct: 668 VSRDLWCDGEADCSDSSDEWDC 689
Score = 164 bits (415), Expect = 2e-39
Identities = 125/439 (28%), Positives = 173/439 (39%), Gaps = 117/439 (26%)
Query: 2502 NCSCRGGRILQDDLTCRAVNSSCRAQDE---------FECANGECINFSLTCDGVPHCKD 2552
N C G + L C N DE F C G+C+N+SL CDG C D
Sbjct: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGD 333
Query: 2553 KSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC 2612
SDE+ CN T +C +GRC++ C+G DC D SDE+ C+ + G+ E C
Sbjct: 334 LSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVE--C 387
Query: 2613 RDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWV 2672
R+G CI ++ +C+ DC+D SDE NCS S + G + L+ PC C S +
Sbjct: 388 RNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSC--QEGDQRCLYNPC--LDSCGGSS-L 442
Query: 2673 CDGANDCGDYSDERDCPGVKRPRCP---------LNYFACPSGRCIPMSW---------- 2713
CD N + S C + C NYF + + +SW
Sbjct: 443 CDPNNSLNNCS---QCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQ 499
Query: 2714 -----------------TCDKEDD---------CEHGE---------------DETHCNK 2732
CD CEH + ++T C++
Sbjct: 500 TNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQ 559
Query: 2733 F-------------------CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKT 2773
F CS + F+C++ +C+ CDG DC D SDE +
Sbjct: 560 FPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDE------EN 613
Query: 2774 CGPSS---FSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQC 2830
CG + CP C+ +CDG DC D DE C S C D E C N C
Sbjct: 614 CGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK---NC---SFCQDDELECANHAC 667
Query: 2831 IPKHFVCDHDRDCADGSDE 2849
+ + CD + DC+D SDE
Sbjct: 668 VSRDLWCDGEADCSDSSDE 686
Score = 155 bits (393), Expect = 7e-37
Identities = 86/223 (38%), Positives = 112/223 (50%), Gaps = 15/223 (6%)
Query: 3483 SDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542
S + N Q+ CG E SG CIP + +C+G +DC D SDE C E F
Sbjct: 258 SPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENL-----FH 312
Query: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCAD 3602
C +C+ CD +DCGD SDE++C P +E C +GRCIA W CDGDHDC D
Sbjct: 313 CHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHR--CGDGRCIAMEWVCDGDHDCVD 370
Query: 3603 GSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCN 3662
SDE +C+ +C++G CIP ++CD D DC DGSDEE C +C + +C
Sbjct: 371 KSDEVNCSCH-SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRC- 428
Query: 3663 NTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKN 3705
L P C G C N+ N C++ C P C N
Sbjct: 429 --LYNPCLDSCGGSSLCDPNNSLN--NCSQ--CEPITLELCMN 465
Score = 155 bits (391), Expect = 1e-36
Identities = 141/469 (30%), Positives = 186/469 (39%), Gaps = 101/469 (21%)
Query: 2524 CRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNML 2583
C + F CA+G CI L C+G C D SDE ++CN C + C G+C++ L
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDE--AHCN---CSENLFHCHTGKCLNYSL 323
Query: 2584 WCNGADDCGDGSDE--IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
C+G DDCGD SDE CN T E RC DG CI C+ DC D SDE+NCS
Sbjct: 324 VCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS- 378
Query: 2642 TDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYF 2701
C S +G++ C R C ++ CDG DC D SDE +C ++
Sbjct: 379 --CHS------QGLV--EC-RNGQCIPSTFQCDGDEDCKDGSDEENCSVIQT-------- 419
Query: 2702 ACPSG--RCI--PMSWTCDKEDDCEHGEDETHCNKFCSEAQFE-CQN------------- 2743
+C G RC+ P +C C+ +C++ C E C N
Sbjct: 420 SCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ-CEPITLELCMNLPYNSTSYPNYFG 478
Query: 2744 HRCISKQWLCDGSD------------------------DCGDGSDEAAHCEGKTCGPSSF 2779
HR + + S C + E C S
Sbjct: 479 HRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKE 538
Query: 2780 SCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCL----YNSTCDDREFMCQNRQCIPKH 2834
C V +W D DC+ +E S CL Y C F C++ QC+
Sbjct: 539 RCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLAS 596
Query: 2835 FVCDHDRDCADGSDESPECEYPTCGPSE---FRCANGRCLSSRQWECDGENDCHDQSDEA 2891
CD DC D SDE CG E + C + + CDG DC D DE
Sbjct: 597 RRCDGQADCDDDSDEE------NCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDE- 649
Query: 2892 PKN-PHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC 2939
KN C E + C++ CV+ L C+G+ DC DSSDE C
Sbjct: 650 -KNCSFCQDDELE--------CANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 151 bits (382), Expect = 1e-35
Identities = 123/454 (27%), Positives = 172/454 (37%), Gaps = 122/454 (26%)
Query: 805 NKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANS 864
N + G C + L G C D+ C NP+ E C +
Sbjct: 309 NLFHCHTGKCLNYSLVCDGYDDCGDLSDEQ------NCDCNPTT---------EHRCGDG 353
Query: 865 RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSE 924
RCI W CDGD+DC+D SDE CH +C N +CIP+ + CDGD DC +
Sbjct: 354 RCIAMEWVCDGDHDCVDKSDEVNCSCHSQGL----VECRNGQCIPSTFQCDGDEDCKDGS 409
Query: 925 DESNATCSARTCPPNQFSCASGRCIPI---SWTCDLDDDC-------------------- 961
DE N + +C C C+ S CD ++
Sbjct: 410 DEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYN 469
Query: 962 --------GDRSDESASCAYPTC-FP----------LTQFTC---------NNGR----- 988
G R+ + AS ++ + FP L F+C N G
Sbjct: 470 STSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPC 529
Query: 989 ---CININWRCDN-----------DNDCG----DNSDEAGCS------HSCSSTQFKCNS 1024
C + RC++ D DC +NSD C CS + FKC S
Sbjct: 530 RALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRS 589
Query: 1025 GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDG 1084
G+C+ CDG DC D SDE + C + D ++C + C+ CDG
Sbjct: 590 GQCVLASRRCDGQADCDDDSDEENCGCKER----------DLWECPSNKQCLKHTVICDG 639
Query: 1085 DTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA 1144
DC D DEK+C C + C + A C+S+ CDG+ DC D+SDE +C +L+
Sbjct: 640 FPDCPDYMDEKNCS----FCQDD-ELECANHA-CVSRDLWCDGEADCSDSSDEWDCVTLS 693
Query: 1145 CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
N+S L + + C DG E
Sbjct: 694 INV-------NSSSFLMVHRAATEHHVCADGWQE 720
Score = 149 bits (375), Expect = 8e-35
Identities = 125/430 (29%), Positives = 178/430 (41%), Gaps = 94/430 (21%)
Query: 3466 CIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSD 3525
CIP C+ NDC D SDE A+C C + F C +G+C+ CDG DDCGD SD
Sbjct: 282 CIPGKLQCNGYNDCDDWSDE-AHCN---CSENLFHCH-TGKCLNYSLVCDGYDDCGDLSD 336
Query: 3526 EPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
E +C+ T + RC + RC+ W CD D+DC D SDE +C+ S+ C NG
Sbjct: 337 EQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCH--SQGLVECRNG 390
Query: 3586 RCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSG--HCI--PLRWRCDADADCMDG 3641
+CI ++CDGD DC DGSDE++C+ + Q C+ G C+ P C + C
Sbjct: 391 QCIPSTFQCDGDEDCKDGSDEENCS----VIQTSCQEGDQRCLYNPCLDSCGGSSLCDPN 446
Query: 3642 SDEEACGT-----------------------GVRTCPLDEFQCNNTL------------- 3665
+ C G RT ++L
Sbjct: 447 NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYL 506
Query: 3666 ----CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDN 3721
C L KCD N+ E+ C R +C ++ RC++ V +G Q +
Sbjct: 507 MFFSCTILVPKCDV------NTGEHIPPC-RALCEHSKE-RCES--VLGIVGLQWPEDTD 556
Query: 3722 CG----DGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCS 3777
C + +D + C P + C F CR+ +C+ +S RC+ DC D SDEE+C
Sbjct: 557 CSQFPEENSDNQTCLMPDEYVEECSPS-HFKCRSGQCVLASRRCDGQADCDDDSDEENCG 615
Query: 3778 ID-------PKLTSCATNASICG---------DEARCVRTE----KAAYCACRSGFHTVP 3817
P C + IC DE C + + A AC S
Sbjct: 616 CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCD 675
Query: 3818 GQPGCQDINE 3827
G+ C D ++
Sbjct: 676 GEADCSDSSD 685
Score = 148 bits (374), Expect = 1e-34
Identities = 118/414 (28%), Positives = 161/414 (38%), Gaps = 110/414 (26%)
Query: 3325 SDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPG-QFQCST 3383
SD C NC+ + F C KC+ + CD DDCGD SDE +C C P + +C
Sbjct: 299 SDEAHC--NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQ-NCD---CNPTTEHRCGD 352
Query: 3384 GICTNPAFICDGDNDCQDNSDEANCDIHV----------CLPSQFKCTNTNRCIPG---- 3429
G C ++CDGD+DC D SDE NC H C+PS F+C C G
Sbjct: 353 GRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEE 412
Query: 3430 ---------------------IFRCNGQDNCGDGEDERDCPEV---------------TC 3453
+ C G C +C + T
Sbjct: 413 NCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTS 472
Query: 3454 APNQFQCSITKR--------------------------CIPRVWVCDRDNDCVDGSDEPA 3487
PN F K C V CD V+ +
Sbjct: 473 YPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCD-----VNTGEHIP 527
Query: 3488 NCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTC----------E 3537
C + C + RC+ + +W D DC S P+E D +TC
Sbjct: 528 PCRAL-CEHSKERCESVLGIVGLQWPED--TDC---SQFPEENSDNQTCLMPDEYVEECS 581
Query: 3538 PYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESE-FSC-ANGRCIAGRWKCD 3595
P F+C++ +CV +CD DC D+SDEE+C C E + + C +N +C+ CD
Sbjct: 582 PSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHTVICD 638
Query: 3596 GDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGT 3649
G DC D DEK+C+ C D+ +C + C+ CD +ADC D SDE C T
Sbjct: 639 GFPDCPDYMDEKNCS-FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVT 691
Score = 142 bits (358), Expect = 8e-33
Identities = 135/502 (26%), Positives = 192/502 (38%), Gaps = 112/502 (22%)
Query: 2593 DGSDE---IPCNKTACGVGEFRCRDGTCIGNSS-----RCNQFVDCEDASDEMNCSATDC 2644
DG D +PC ++ C + C + N S RC+QF + ++S+ C
Sbjct: 202 DGDDSHGLLPC-RSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRI----C 256
Query: 2645 SSYFRLGVKGVLFQPCER----TSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY 2700
S + K +L E + +C C+G NDC D+SDE C C N
Sbjct: 257 FSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC------NCSENL 310
Query: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEA-QFECQNHRCISKQWLCDGSDDC 2759
F C +G+C+ S CD DDC DE +C+ C+ + C + RCI+ +W+CDG DC
Sbjct: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCD--CNPTTEHRCGDGRCIAMEWVCDGDHDC 368
Query: 2760 GDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAA--------- 2810
D SDE +C +C C+P + CDGD+DC DG+DE +
Sbjct: 369 VDKSDEV-NC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEG 424
Query: 2811 --GCLYN---------STCDDREFMCQNRQC-----------------IPKHFVCDHDRD 2842
CLYN S CD + QC P +F ++
Sbjct: 425 DQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKE 484
Query: 2843 CADGSDES-----------------------PECEYPT----------CGPSEFRCANGR 2869
+ + S P+C+ T C S+ RC +
Sbjct: 485 ASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVL 544
Query: 2870 CLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN--ASSQFLCSSGRCVAEALLCNGQ 2927
+ QW D DC +E N C + + S F C SG+CV + C+GQ
Sbjct: 545 GIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQ 602
Query: 2928 DDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCA----DV 2983
DC D SDE C C R L C + + LK C P D + C+ D
Sbjct: 603 ADCDDDSDEENC---GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDE 659
Query: 2984 DECSTTFPCSQRCINTHGSYKC 3005
EC+ C R + G C
Sbjct: 660 LECA-NHACVSRDLWCDGEADC 680
Score = 133 bits (334), Expect = 5e-30
Identities = 93/256 (36%), Positives = 113/256 (44%), Gaps = 52/256 (20%)
Query: 1002 CGDNSDEAGCSHSCSSTQ-FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPG 1060
C E G C + F C SG CIP C+G NDC D+SDE H NC+
Sbjct: 256 CFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFH--- 312
Query: 1061 GCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCIS 1120
CHT G C+ CDG DC D SDE++C+ C+P+ + C D RCI+
Sbjct: 313 -CHT--------GKCLNYSLVCDGYDDCGDLSDEQNCD-----CNPTTEHRCGDG-RCIA 357
Query: 1121 KAWVCDGDNDCEDNSDEENCESLACRPPS-HPCANNTSVCLPPDKLCDGNDDCGDGSDEG 1179
WVCDGD+DC D SDE NC +C C N C+P CDG++DC DGSDE
Sbjct: 358 MEWVCDGDHDCVDKSDEVNC---SCHSQGLVECRNGQ--CIPSTFQCDGDEDCKDGSDE- 411
Query: 1180 ELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQ 1239
NCSV I SC G + C + + C S CD
Sbjct: 412 --------------ENCSV-----IQTSCQEG------DQRC-LYNPCLDSCGGSSLCDP 445
Query: 1240 NKFSVKCSCYEGWVLE 1255
N CS E LE
Sbjct: 446 NNSLNNCSQCEPITLE 461
Score = 114 bits (284), Expect = 3e-24
Identities = 71/240 (29%), Positives = 113/240 (47%), Gaps = 39/240 (16%)
Query: 2720 DCEHGEDETH----CNKFCSEAQFECQNHR-CISKQW----LCDGSDDCGDGSDEAAHC- 2769
+C D++H C FC A+ C++ ++ W C + + S+ + C
Sbjct: 198 ECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICF 257
Query: 2770 -----EGKT--CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDRE 2822
GK CG + +C+P + C+G DC D +DE+ + C +
Sbjct: 258 SPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEA-------HCNCSENL 310
Query: 2823 FMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGP-SEFRCANGRCLSSRQWECDGE 2881
F C +C+ VCD DC D SDE C+ C P +E RC +GRC+ + +W CDG+
Sbjct: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQ-NCD---CNPTTEHRCGDGRCI-AMEWVCDGD 365
Query: 2882 NDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 2941
+DC D+SDE +C+ C++ C +G+C+ C+G +DC D SDE C +
Sbjct: 366 HDCVDKSDEV----NCS-----CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Score = 89.7 bits (221), Expect = 6e-17
Identities = 104/417 (24%), Positives = 154/417 (36%), Gaps = 107/417 (25%)
Query: 2472 NDTNSCELSPC---RINNGGCQDLCLLTHQGH--------VNCSC--------RGGRIL- 2511
+D +C+ +P R +G C + + H VNCSC R G+ +
Sbjct: 335 SDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIP 394
Query: 2512 --------------QDDLTCRAVNSSCRAQDEFECANGECINF---SLTCD---GVPHCK 2551
D+ C + +SC+ D+ C C++ S CD + +C
Sbjct: 395 STFQCDGDEDCKDGSDEENCSVIQTSCQEGDQ-RCLYNPCLDSCGGSSLCDPNNSLNNCS 453
Query: 2552 D--------------KSDEKPSYCNSRRCKKT--------FRQCSNGRCVSNMLWCNGAD 2589
S P+Y R K+ F C +++ +
Sbjct: 454 QCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTI 513
Query: 2590 -----DCGDGSDEIPCNKTACGVGEFRCRD-----GTCIGNSSRCNQFVDCEDASDEMNC 2639
D G PC + C + RC G + C+QF E+ SD C
Sbjct: 514 LVPKCDVNTGEHIPPC-RALCEHSKERCESVLGIVGLQWPEDTDCSQFP--EENSDNQTC 570
Query: 2640 SATD-----CS-SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKR 2693
D CS S+F+ R+ C S CDG DC D SDE +C +R
Sbjct: 571 LMPDEYVEECSPSHFKC-----------RSGQCVLASRRCDGQADCDDDSDEENCGCKER 619
Query: 2694 PRCPLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWL 2752
+ + CPS + C+ + CD DC DE +C+ FC + + EC NH C+S+
Sbjct: 620 -----DLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCS-FCQDDELECANHACVSRDLW 673
Query: 2753 CDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIA 2809
CDG DC D SDE C + +S S H E + CADG E ++
Sbjct: 674 CDGEADCSDSSDE-WDCVTLSINVNSSSFLMVHRAATEHHV------CADGWQEILS 723
Score = 80.5 bits (197), Expect = 4e-14
Identities = 57/182 (31%), Positives = 78/182 (42%), Gaps = 24/182 (13%)
Query: 3325 SDGRTC------VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPP-DCPEFKCRPG 3377
SD +TC V C+ S F C++ +C+ +CD + DC D SDE C E
Sbjct: 565 SDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL--- 621
Query: 3378 QFQC-STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQ 3436
++C S C ICDG DC D DE NC C + +C N + C+ C+G+
Sbjct: 622 -WECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELECAN-HACVSRDLWCDGE 677
Query: 3437 DNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN---CTQMT 3493
+C D DE DC ++ N + R V C DG E + C QM
Sbjct: 678 ADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHV------CADGWQEILSQLACKQMG 731
Query: 3494 CG 3495
G
Sbjct: 732 LG 733
Score = 79.7 bits (195), Expect = 6e-14
Identities = 52/177 (29%), Positives = 82/177 (46%), Gaps = 17/177 (9%)
Query: 3330 CVSNCTASQFVCKNDK-CIPFWWKCDTEDDCGDHSDEP--------PDCPEFKCRPGQFQ 3380
C + C S+ C++ + W DT DC +E PD +C P F+
Sbjct: 529 CRALCEHSKERCESVLGIVGLQWPEDT--DCSQFPEENSDNQTCLMPDEYVEECSPSHFK 586
Query: 3381 CSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCG 3440
C +G C + CDG DC D+SDE NC ++C + +C+ C+G +C
Sbjct: 587 CRSGQCVLASRRCDGQADCDDDSDEENCGCKE--RDLWECPSNKQCLKHTVICDGFPDCP 644
Query: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVD 3497
D DE++C C ++ +C+ C+ R CD + DC D SDE +C ++ V+
Sbjct: 645 DYMDEKNCS--FCQDDELECA-NHACVSRDLWCDGEADCSDSSDE-WDCVTLSINVN 697
Score = 58.5 bits (140), Expect = 1e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 11/90 (12%)
Query: 27 CSPK-QFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
C+P + C D CI+ W CDG+ DC D SDE C C+ + C
Sbjct: 342 CNPTTEHRCGDG-RCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQ--------C 392
Query: 86 VPMSRLCNGVQDCMDGSDEGPHCRELQGNC 115
+P + C+G +DC DGSDE +C +Q +C
Sbjct: 393 IPSTFQCDGDEDCKDGSDE-ENCSVIQTSC 421
Score = 58.2 bits (139), Expect = 2e-07
Identities = 46/146 (31%), Positives = 58/146 (39%), Gaps = 23/146 (15%)
Query: 2904 CNASSQFLCSSGRCVAEALLCNGQDDCGDSSDER---------GCHINECLSRKLSGCS- 2953
C FLC+SG C+ L CNG +DC D SDE CH +CL+ L C
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLV-CDG 327
Query: 2954 -QDCEDLKIGFKCRCRPGFRLK-DDGRTCADVDECSTTFPCSQR------CINTHGSYKC 3005
DC DL C C P + DGR A C C + ++ G +C
Sbjct: 328 YDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVEC 387
Query: 3006 ---LCVEGYAPRGGDPHSCKAVTDEE 3028
C+ GD CK +DEE
Sbjct: 388 RNGQCIPSTFQCDGD-EDCKDGSDEE 412
Score = 55.8 bits (133), Expect = 9e-07
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 10/96 (10%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
CSP F CR C+ RCDG+ DC D SDE C + C N+ C+
Sbjct: 580 CSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ-------CL 631
Query: 87 PMSRLCNGVQDCMDGSDEG--PHCRELQGNCSRLGC 120
+ +C+G DC D DE C++ + C+ C
Sbjct: 632 KHTVICDGFPDCPDYMDEKNCSFCQDDELECANHAC 667
Score = 43.9 bits (102), Expect = 0.004
Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 5/74 (6%)
Query: 3741 CKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN-----ASICGDE 3795
C + FLC + C+ L+CN ++DC D SDE C+ L C T + +C
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGY 328
Query: 3796 ARCVRTEKAAYCAC 3809
C C C
Sbjct: 329 DDCGDLSDEQNCDC 342
Score = 41.6 bits (96), Expect = 0.018
Identities = 43/183 (23%), Positives = 66/183 (36%), Gaps = 27/183 (14%)
Query: 27 CSPKQFACRDQITCISKGW----RCDGERDCPDGSDEAPEIC--PQS---KAQRCQPNEH 77
C + C + ++ W RC R+ + S+ + IC PQ K C E+
Sbjct: 216 CEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVS-RICFSPQQENGKQLLCGRGEN 274
Query: 78 NCLGTELCVPMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---------CVPT 127
+ +C+P CNG DC D SDE +C E +C C ++ C
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDL 334
Query: 128 LDGPTCYCNSSFQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGYLLQPDN 185
D C CN + + C D ++ C C + C C L++ N
Sbjct: 335 SDEQNCDCNPTTE-----HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRN 389
Query: 186 RSC 188
C
Sbjct: 390 GQC 392
Score = 34.3 bits (77), Expect = 2.9
Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE 59
C + C + C+S+ CDGE DC D SDE
Sbjct: 655 CQDDELECANH-ACVSRDLWCDGEADCSDSSDE 686
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 191 bits (486), Expect = 1e-47
Identities = 142/449 (31%), Positives = 182/449 (40%), Gaps = 97/449 (21%)
Query: 827 CACAEDQVLDADGVTCLANPSYVPPPQCQPGEFA----------CANSRCIQERWKCDGD 876
C C E +L G CL P+ P C+ G + C N C + +W C GD
Sbjct: 1312 CFCPEGTLLH--GGACL-EPASCP---CEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGD 1365
Query: 877 N----DCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCS 932
+ + E ALC EN C+P+ WLCD +DCG+ DE C+
Sbjct: 1366 GGHCEELVPACAEGEALCQ-----------ENGHCVPHGWLCDNQDDCGDGSDEEG--CA 1412
Query: 933 ARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCINI 992
A C Q +C+SG C+P++ CD DDCGD +DE +YP P C +GRC+
Sbjct: 1413 APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP---SYPC--PQGLLACADGRCLPP 1467
Query: 993 NWRCDNDNDCGDNSDEAGC--SHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHAN 1050
CD DC D +DE C +C + C G C+ CDG DC D +DE +
Sbjct: 1468 ALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGH 1527
Query: 1051 C------TNQATRPPG--------------------GCHTDEFQCRLDGLCIPLRWRCDG 1084
C T A+ PG C EF+C G C P WRCD
Sbjct: 1528 CPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCG-SGECTPRGWRCDQ 1586
Query: 1085 DTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDE------- 1137
+ DC D SDE+ C G C P C C+S +CDG C D SDE
Sbjct: 1587 EEDCADGSDERGCGG---PCAPH-HAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642
Query: 1138 ------ENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNN-- 1189
N L C P + C N T C+ +CDG DCG G ++
Sbjct: 1643 LPALGGPNRTGLPC--PEYTCPNGT--CIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWG 1698
Query: 1190 -----GGCSHNCSV-APGEGIVCSCPLGM 1212
G CS C G CS PLG+
Sbjct: 1699 PWSPWGPCSRTCGPWGQGRSRRCS-PLGL 1726
Score = 189 bits (481), Expect = 4e-47
Identities = 123/380 (32%), Positives = 155/380 (40%), Gaps = 76/380 (20%)
Query: 3365 EPPDCP----EFKCRPG---QFQCSTGICTNPAFICDGDNDCQDNSDEANCD--IHVCLP 3415
EP CP PG Q C C + C GD +C+ + C
Sbjct: 1327 EPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGDG--------GHCEELVPACAE 1378
Query: 3416 SQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDR 3475
+ C C+P + C+ QD+CGDG DE C C Q CS + C+P +CDR
Sbjct: 1379 GEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCS-SGHCLPLALLCDR 1437
Query: 3476 DNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC-DER 3534
+DC DG+DEP+ C C D GRC+P CDG DC D +DE E C +
Sbjct: 1438 QDDCGDGTDEPS----YPCPQGLLACAD-GRCLPPALLCDGHPDCLDAADE--ESCLGQV 1490
Query: 3535 TCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDE--------------------------- 3567
TC P + C + C+ CD DC D +DE
Sbjct: 1491 TCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLD 1550
Query: 3568 ------ESCTPRP-CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQC 3620
S +P P C EF C +G C W+CD + DCADGSDE+ C C C
Sbjct: 1551 TASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPC 1610
Query: 3621 KSG-HCIPLRWRCDADADCMDGSDE--EACG----------TGVRTCPLDEFQCNNTLCK 3667
G HC+ CD C DGSDE +ACG TG+ P E+ C N C
Sbjct: 1611 ARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGL---PCPEYTCPNGTCI 1667
Query: 3668 PLAWKCDGEDDCGDNSDENP 3687
CDG+ DCG P
Sbjct: 1668 GFQLVCDGQPDCGRPGQVGP 1687
Score = 185 bits (469), Expect = 1e-45
Identities = 150/533 (28%), Positives = 201/533 (37%), Gaps = 95/533 (17%)
Query: 2491 DLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQD--EFECANGECINF-SLTCDGV 2547
D C G C C D+ + R+Q+ +C G+ TC
Sbjct: 1232 DACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACGPTCP-- 1289
Query: 2548 PHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGAD-DCGDGSDEIP------- 2599
P C ++ E +C C + C G + A C G + P
Sbjct: 1290 PTCHEQHPEPGWHCQVVACVEGCF-CPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQK 1348
Query: 2600 -CNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQ 2658
C C G++ C G+ C + V + +
Sbjct: 1349 DCGNCTCQEGQWHCG-----GDGGHCEELVPACAEGEAL--------------------- 1382
Query: 2659 PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKE 2718
C+ C W+CD +DCGD SDE C P C C SG C+P++ CD++
Sbjct: 1383 -CQENGHCVPHGWLCDNQDDCGDGSDEEGCAA---PGCGEGQMTCSSGHCLPLALLCDRQ 1438
Query: 2719 DDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS 2778
DDC G DE C + C + RC+ LCDG DC D +DE + TC P
Sbjct: 1439 DDCGDGTDEPSYP--CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGE 1496
Query: 2779 FSC-PGTHVCVPERWLCDGDKDCADGADES--------------------------IAAG 2811
SC GT C+ LCDG DC DGADE A+
Sbjct: 1497 VSCVDGT--CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASS 1554
Query: 2812 CLYNST----CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCAN 2867
L +++ C EF C + +C P+ + CD + DCADGSDE C P C P CA
Sbjct: 1555 PLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDER-GCGGP-CAPHHAPCAR 1612
Query: 2868 G-RCLSSRQWECDGENDCHDQSDEAPKN----PHCTSQEHKCNASSQFLCSSGRCVAEAL 2922
G C+S Q CDG C D SDE P P ++ C +G C+ L
Sbjct: 1613 GPHCVSPEQL-CDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQL 1671
Query: 2923 LCNGQDDC------GDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRP 2969
+C+GQ DC G S +E+GC S CS+ C G RC P
Sbjct: 1672 VCDGQPDCGRPGQVGPSPEEQGCGAWGPWS-PWGPCSRTCGPWGQGRSRRCSP 1723
Score = 161 bits (407), Expect = 2e-38
Identities = 120/421 (28%), Positives = 157/421 (37%), Gaps = 72/421 (17%)
Query: 3502 KDSGRCI--PARWKCDGEDDCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDY 3557
KD G C +W C G+ G +E C E C+ +N CVP W CD
Sbjct: 1348 KDCGNCTCQEGQWHCGGD---GGHCEELVPACAEGEALCQ------ENGHCVPHGWLCDN 1398
Query: 3558 DNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQ 3617
+DCGD SDEE C C E + +C++G C+ CD DC DG+DE C
Sbjct: 1399 QDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYP--CPQGL 1456
Query: 3618 FQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGED 3677
C G C+P CD DC+D +DEE+C G TC E C + C CDG
Sbjct: 1457 LACADGRCLPPALLCDGHPDCLDAADEESC-LGQVTCVPGEVSCVDGTCLGAIQLCDGVW 1515
Query: 3678 DCGDNSDENPEEC-----------------------------ARFVCPPNRPF--RCKND 3706
DC D +DE P C + PP PF RC +
Sbjct: 1516 DCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSG 1575
Query: 3707 RVCLWIGRQCDGTDNCGDGTDEEDCEPPTA-HTTHCKDKKEFLCRNQRCLSSSLRCNMFD 3765
C G +CD ++C DG+DE C P A H C R C+S C+
Sbjct: 1576 E-CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPC-------ARGPHCVSPEQLCDGVR 1627
Query: 3766 DCGDGSDE--EDCSIDPKLTS-----------CATNASICGDEARCVRTEKAAYCACRSG 3812
C DGSDE + C P L N + G + C + C
Sbjct: 1628 QCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVC---DGQPDCGRPGQ 1684
Query: 3813 FHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYI 3872
P + GC +G CS+ C G C+ + C + Q +
Sbjct: 1685 VGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFT 1744
Query: 3873 A 3873
A
Sbjct: 1745 A 1745
Score = 143 bits (360), Expect = 4e-33
Identities = 145/542 (26%), Positives = 190/542 (35%), Gaps = 121/542 (22%)
Query: 801 QVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCL---------------AN 845
Q G C + G C L A CAE + L + C+ ++
Sbjct: 1356 QEGQWHCGGDGGHCEELVPA--------CAEGEALCQENGHCVPHGWLCDNQDDCGDGSD 1407
Query: 846 PSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENN 905
P C G+ C++ C+ CD +DC D +DE + CP C +
Sbjct: 1408 EEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP-----SYPCPQGLLACADG 1462
Query: 906 RCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRS 965
RC+P LCDG DC ++ DE + TC P + SC G C+ CD DC D +
Sbjct: 1463 RCLPPALLCDGHPDCLDAADEESCLGQV-TCVPGEVSCVDGTCLGAIQLCDGVWDCPDGA 1521
Query: 966 DE----------------------------------SASCAYPTCFPLTQFTCNNGRCIN 991
DE SAS A P C P +F C +G C
Sbjct: 1522 DEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPA-PPCGPF-EFRCGSGECTP 1579
Query: 992 INWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSG-RCIPEHWTCDGDNDCGDYSDETHAN 1050
WRCD + DC D SDE GC C+ C G C+ CDG C D SDE
Sbjct: 1580 RGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDA 1639
Query: 1051 CTN-QATRPPG--GCHTDEFQCRLDGLCIPLRWRCDGDTDC------MDSSDEKSCEG-- 1099
C A P G E+ C +G CI + CDG DC S +E+ C
Sbjct: 1640 CGGLPALGGPNRTGLPCPEYTCP-NGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWG 1698
Query: 1100 -------VTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPC 1152
+ C P +G S RC + N +S AC + P
Sbjct: 1699 PWSPWGPCSRTCGP---WGQGRSRRCSPLGLL------VLQNCPGPEHQSQACFTAACPV 1749
Query: 1153 ANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCS----- 1207
S P +C ++ C C S NGG C+ PG G+ +
Sbjct: 1750 DGEWST-WSPWSVC--SEPCRGTMTRQRQCH--SPQNGG--RTCAALPG-GLHSTRQTKP 1801
Query: 1208 CPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCS-----------CYEGWVLEP 1256
CP + G N TC + C CD V C C EG VL
Sbjct: 1802 CP---QDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGS 1858
Query: 1257 DG 1258
+G
Sbjct: 1859 EG 1860
Score = 116 bits (290), Expect = 6e-25
Identities = 126/510 (24%), Positives = 180/510 (35%), Gaps = 132/510 (25%)
Query: 3324 GSDGRTCVS-NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEP---------------- 3366
GSD C + C Q C + C+P CD +DDCGD +DEP
Sbjct: 1405 GSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRC 1464
Query: 3367 ----------PDC----------PEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDE- 3405
PDC + C PG+ C G C +CDG DC D +DE
Sbjct: 1465 LPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEG 1524
Query: 3406 -ANCDI--------------------------------HVCLPSQFKCTNTNRCIPGIFR 3432
+C + C P +F+C + C P +R
Sbjct: 1525 PGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRC-GSGECTPRGWR 1583
Query: 3433 CNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE------- 3485
C+ +++C DG DER C CAP+ C+ C+ +CD C DGSDE
Sbjct: 1584 CDQEEDCADGSDERGCGG-PCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642
Query: 3486 -PA----NCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGD----GSDEPKEECD---- 3532
PA N T + C E+ C +G CI + CDG+ DCG G ++ C
Sbjct: 1643 LPALGGPNRTGLPC--PEYTC-PNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGP 1699
Query: 3533 -------ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPC-------SES 3578
RTC P+ + ++ RC P N G ++C C + S
Sbjct: 1700 WSPWGPCSRTCGPWG-QGRSRRCSP-LGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWS 1757
Query: 3579 EFSCANGRC---IAGRWKC----DGDHDCA---DGSDEKDCTPRCDMD---QFQCKSGH- 3624
+S + C + + +C +G CA G T C D C SG
Sbjct: 1758 PWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDGCPNATC-SGEL 1816
Query: 3625 ----CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCK-PLAWKCDGEDDC 3679
C P CD + + + CG+ CP + + C P C +
Sbjct: 1817 MFQPCAPCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWCVWPRQCPCLVDGAR 1876
Query: 3680 GDNSDENPEECARFVCPPNRPFRCKNDRVC 3709
+C +C RP RC+ + C
Sbjct: 1877 YWPGQRIKADCQLCICQDGRPRRCRLNPDC 1906
Score = 83.6 bits (205), Expect = 4e-15
Identities = 83/316 (26%), Positives = 117/316 (37%), Gaps = 63/316 (19%)
Query: 3555 CDYDNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRC 3613
C YD D+ + C + CA +G + R + C G + C P C
Sbjct: 1229 CLYDACGCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSLQCEGGQVYEACGPTC 1288
Query: 3614 DMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGV----------RTCPLD------ 3657
C H P W C A C++G C G +CP +
Sbjct: 1289 PPT---CHEQHPEP-GWHCQVVA-CVEGC---FCPEGTLLHGGACLEPASCPCEWGRNSF 1340
Query: 3658 ------EFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLW 3711
+ C N C+ W C G+ G + +E CA C+ + C+
Sbjct: 1341 PPGSVLQKDCGNCTCQEGQWHCGGD---GGHCEELVPACAEGEA------LCQENGHCVP 1391
Query: 3712 IGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGS 3771
G CD D+CGDG+DEE C P + + C + CL +L C+ DDCGDG+
Sbjct: 1392 HGWLCDNQDDCGDGSDEEGCAAPGC------GEGQMTCSSGHCLPLALLCDRQDDCGDGT 1445
Query: 3772 DEEDCSIDPKLTSCATN-----ASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDIN 3826
DE L +CA A +C C+ + A +C VPG+ C D
Sbjct: 1446 DEPSYPCPQGLLACADGRCLPPALLCDGHPDCL--DAADEESCLGQVTCVPGEVSCVD-- 1501
Query: 3827 ECLRFGTC---SQLCN 3839
GTC QLC+
Sbjct: 1502 -----GTCLGAIQLCD 1512
Score = 80.1 bits (196), Expect = 5e-14
Identities = 64/190 (33%), Positives = 80/190 (42%), Gaps = 42/190 (22%)
Query: 3 TPPLLLL-------LPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPD 55
TPP L L S+ +A+A AP C P +F C C +GWRCD E DC D
Sbjct: 1535 TPPASTLPGPSPGSLDTASSPLASASPAPP-CGPFEFRCGSG-ECTPRGWRCDQEEDCAD 1592
Query: 56 GSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPH-CRELQG- 113
GSDE + C P+ C CV +LC+GV+ C DGSDEGP C L
Sbjct: 1593 GSDE------RGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPAL 1646
Query: 114 ---NCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKT----------------CKDFDEC 154
N + L C + P TC FQL DG+ C +
Sbjct: 1647 GGPNRTGLPCPEYTCP---NGTCI---GFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPW 1700
Query: 155 SVYGTCSQLC 164
S +G CS+ C
Sbjct: 1701 SPWGPCSRTC 1710
Score = 68.6 bits (166), Expect = 1e-10
Identities = 41/127 (32%), Positives = 49/127 (38%), Gaps = 19/127 (14%)
Query: 846 PSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENN 905
P PP QC PG+ C C+++ CDG DCLD SDE C N
Sbjct: 2383 PGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDER--------------HCARN 2428
Query: 906 RC-----IPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
+P W + S C P+Q SC SG C+ CDL D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488
Query: 961 CGDRSDE 967
C D SDE
Sbjct: 2489 CQDGSDE 2495
Score = 68.2 bits (165), Expect = 2e-10
Identities = 105/424 (24%), Positives = 132/424 (31%), Gaps = 121/424 (28%)
Query: 3366 PPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHV-----CLPSQFKC 3420
P P +C PGQ C C A +CDG DC D SDE +C ++ LP+ +
Sbjct: 2383 PGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAA 2442
Query: 3421 TNT-----NRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDR 3475
+ +PG+ C+P+Q C + C+ CD
Sbjct: 2443 STVPFMMPTMALPGL----------------PASRALCSPSQLSCG-SGECLSAERRCDL 2485
Query: 3476 DNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWK--CDGEDDCGDGSDEPKEE--- 3530
DC DGSDE C D C+ A W CG G ++E
Sbjct: 2486 RPDCQDGSDEDG-------------CVD---CVLAPWSVWSSCSRSCGLGLTFQRQELLR 2529
Query: 3531 --CDERTCEPYQFR---CKNNRC-VPGRW-------QCDYDNDCGDNSDEESCTPRPCSE 3577
+C +FR C C V G W C G S + SC P
Sbjct: 2530 PPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKN 2589
Query: 3578 SEFSC---ANGRCIAGRWKCDGDHDCADGS-------DEKDCTPRC-----DMDQFQCKS 3622
C + R G C G DC G +K P C D + S
Sbjct: 2590 GGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCS 2649
Query: 3623 GHCIPLRWRCDA-----DADCMDGSD------EEACGTGVR---------TCPLDEFQCN 3662
GHC+ RC D C+ S+ EE GV C E C
Sbjct: 2650 GHCVE-GCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQ 2708
Query: 3663 NTLCK-PLAWK-------CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGR 3714
C P W CD CG ARF P N P W G
Sbjct: 2709 PGGCPLPCGWSAWSSWAPCD--RSCGSGVR------ARFRSPSNPP--------AAWGGA 2752
Query: 3715 QCDG 3718
C+G
Sbjct: 2753 PCEG 2756
Score = 63.5 bits (153), Expect = 4e-09
Identities = 51/154 (33%), Positives = 61/154 (39%), Gaps = 42/154 (27%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICP-------------------- 65
TC P + +C D TC+ CDG DCPDG+DE P CP
Sbjct: 1491 TCVPGEVSCVDG-TCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSL 1549
Query: 66 ---------QSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCS 116
S A C P E C G+ C P C+ +DC DGSDE R G C+
Sbjct: 1550 DTASSPLASASPAPPCGPFEFRC-GSGECTPRGWRCDQEEDCADGSDE----RGCGGPCA 1604
Query: 117 RLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
HH P GP +C S QL + C D
Sbjct: 1605 ----PHH-APCARGP--HCVSPEQLCDGVRQCPD 1631
Score = 62.4 bits (150), Expect = 1e-08
Identities = 90/351 (25%), Positives = 117/351 (33%), Gaps = 77/351 (21%)
Query: 2679 CGDY-----SDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEH---------G 2724
CGD+ +D R GV P L A S R P+ C + D H G
Sbjct: 1146 CGDFDGDASNDLRSRQGVLEPTAEL---AAHSWRLSPL---CPEPGDLPHPCTMNTHRAG 1199
Query: 2725 EDETHCNKFCS------EAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS 2778
C A+ Q H +W + C G D C
Sbjct: 1200 WARARCGALLQPLFTLCHAEVPPQQHY----EWCLYDACGCDSGGDCECLCSAIATYADE 1255
Query: 2779 FSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDRE----FMCQNRQCIPKH 2834
+ G HV + LC +G A G TC ++ + CQ C+
Sbjct: 1256 CARHGHHVRWRSQELCSLQ---CEGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGC 1312
Query: 2835 FVCD----HDRDCADGSDESPECE-----YPTCGPSEFRCANGRCLSSRQWECDGENDCH 2885
F + H C + + S CE +P + C N C QW C G+
Sbjct: 1313 FCPEGTLLHGGACLEPA--SCPCEWGRNSFPPGSVLQKDCGNCTCQEG-QWHCGGDGG-- 1367
Query: 2886 DQSDEAPKNPHCTSQEHKCNASSQFLCS-SGRCVAEALLCNGQDDCGDSSDERGCHINEC 2944
HC C A + LC +G CV LC+ QDDCGD SDE GC C
Sbjct: 1368 ----------HCEELVPAC-AEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGC 1416
Query: 2945 LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCAD-VDECSTTFPCSQ 2994
+++ CS C P L D C D DE S +PC Q
Sbjct: 1417 GEGQMT-CSSG----------HCLPLALLCDRQDDCGDGTDEPS--YPCPQ 1454
Score = 62.0 bits (149), Expect = 1e-08
Identities = 46/155 (29%), Positives = 67/155 (43%), Gaps = 9/155 (5%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
C+ + C++ C+ GW CD + DC DGSDE E C A C + C + C+
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE--EGC---AAPGCGEGQMTC-SSGHCL 1429
Query: 87 PMSRLCNGVQDCMDGSDEGPH-CRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADG 145
P++ LC+ DC DG+DE + C + C+ C + P C + +
Sbjct: 1430 PLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQ 1489
Query: 146 KTCKDFDECSVYGTCSQLCTNTDGSFIC--GCVEG 178
TC + V GTC DG + C G EG
Sbjct: 1490 VTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEG 1524
Score = 59.7 bits (143), Expect = 6e-08
Identities = 56/191 (29%), Positives = 70/191 (36%), Gaps = 49/191 (25%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQ----RCQP-------- 74
C Q C C+ CD + DC DG+DE CPQ RC P
Sbjct: 1416 CGEGQMTCSSG-HCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGH 1474
Query: 75 -------NEHNCLGTELCVPMS------------RLCNGVQDCMDGSDEGPHCRELQGNC 115
+E +CLG CVP +LC+GV DC DG+DEGP G+C
Sbjct: 1475 PDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGP------GHC 1528
Query: 116 SRLGCQHHCVPTLDGPT----CYCNSSFQLQADGKTCKDFD------ECSVYG-TCSQLC 164
TL GP+ +S + C F+ EC+ G C Q
Sbjct: 1529 PLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEE 1588
Query: 165 TNTDGSFICGC 175
DGS GC
Sbjct: 1589 DCADGSDERGC 1599
Score = 59.7 bits (143), Expect = 6e-08
Identities = 117/516 (22%), Positives = 148/516 (28%), Gaps = 161/516 (31%)
Query: 2566 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCN 2625
C +C++G CV C+G DC DGSDE C G G F T +S++
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLALSSAQPG 2293
Query: 2626 QFV----------DCEDASDEMNCSATDCSSYFRLGVKGVLFQ----------------- 2658
Q + + E S T+ GV
Sbjct: 2294 QLLHWPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTTPIPQMEA 2353
Query: 2659 ---PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRP-RCPLNYFACPSGRCIPMSWT 2714
P ++ P A G + PG P +C C C+ +
Sbjct: 2354 RTLPPGMAAVTVVPPHPVTPATPAG----QSVAPGPFPPVQCGPGQTPCEVLGCVEQAQV 2409
Query: 2715 CDKEDDCEHGEDETHCNK-----------------------------------FCSEAQF 2739
CD +DC G DE HC + CS +Q
Sbjct: 2410 CDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQL 2469
Query: 2740 ECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKD 2799
C + C+S + CD DC DGSDE G CV W
Sbjct: 2470 SCGSGECLSAERRCDLRPDCQDGSDE----------------DGCVDCVLAPW------- 2506
Query: 2800 CADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTC- 2858
S + C T +E + R +P C DR S C C
Sbjct: 2507 ---SVWSSCSRSCGLGLTFQRQELL---RPPLPGG-SCPRDR------FRSQSCFVQACP 2553
Query: 2859 -----------GPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKN-----PHCTSQEH 2902
GP C G SRQ C D PKN P + +
Sbjct: 2554 VAGAWAMWEAWGPCSVSCGGGH--QSRQRSC---------VDPPPKNGGAPCPGASQERA 2602
Query: 2903 KCN---ASSQFLCSSGRCVAEALLCNG--QDDCGDSSDERGCHINECLSRKLS-GCSQDC 2956
C S C GR A LC C S CL K + CS C
Sbjct: 2603 PCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPS----------CLDPKANRSCSGHC 2652
Query: 2957 EDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPC 2992
+ CRC PG L D C + EC PC
Sbjct: 2653 VE-----GCRCPPGLLLHD--TRCLPLSEC----PC 2677
Score = 53.9 bits (128), Expect = 4e-06
Identities = 39/125 (31%), Positives = 48/125 (38%), Gaps = 20/125 (16%)
Query: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEIC--------PQSKAQRCQPNEHN 78
C+P C C+S CDG R CPDGSDE P+ C P C E+
Sbjct: 1603 CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCP--EYT 1660
Query: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLG-------CQHHCVPTLDGP 131
C C+ +C+G DC GP E QG C G C C P G
Sbjct: 1661 C-PNGTCIGFQLVCDGQPDCGRPGQVGPSPEE-QG-CGAWGPWSPWGPCSRTCGPWGQGR 1717
Query: 132 TCYCN 136
+ C+
Sbjct: 1718 SRRCS 1722
Score = 50.1 bits (118), Expect = 5e-05
Identities = 33/118 (27%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 895 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISW- 953
C + CE C+ +CDG DC + DE + + P+ + + +P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 954 TCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGC 1011
T L R+ C P +Q +C +G C++ RCD DC D SDE GC
Sbjct: 2451 TMALPGLPASRA---------LCSP-SQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 49.3 bits (116), Expect = 9e-05
Identities = 70/309 (22%), Positives = 97/309 (31%), Gaps = 84/309 (27%)
Query: 967 ESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGC---------SHSCSS 1017
E S P C P C +G C+ CD DC D SDE GC HS +
Sbjct: 2225 EPGSPPAPLC-PGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAK 2283
Query: 1018 TQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRP--PGGC-----HTDEFQC- 1069
T ++ HW +G + + + + TRP PG H + Q
Sbjct: 2284 TLALSSAQPGQLLHWPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMV 2343
Query: 1070 ------RLDGLCIPLRWRC--------------DGDTDCMDSSDEKSCEGVTHVCDPSVK 1109
+++ +P G + C C+
Sbjct: 2344 TTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCE---V 2400
Query: 1110 FGCKDSARCISKAWVCDGDNDCEDNSDEENC----------------------------- 1140
GC + A+ VCDG DC D SDE +C
Sbjct: 2401 LGCVEQAQ------VCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMAL 2454
Query: 1141 -----ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHN 1195
C P C + CL ++ CD DC DGSDE + C C L +
Sbjct: 2455 PGLPASRALCSPSQLSCGSGE--CLSAERRCDLRPDCQDGSDE-DGCVDCVLAPWSVWSS 2511
Query: 1196 CSVAPGEGI 1204
CS + G G+
Sbjct: 2512 CSRSCGLGL 2520
Score = 48.1 bits (113), Expect = 2e-04
Identities = 34/111 (30%), Positives = 46/111 (41%), Gaps = 33/111 (29%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDE----------APEI---------- 63
P C P Q C + + C+ + CDG DC DGSDE P +
Sbjct: 2388 PVQCGPGQTPC-EVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 64 ----------CPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
P S+A C P++ +C G+ C+ R C+ DC DGSDE
Sbjct: 2447 FMMPTMALPGLPASRA-LCSPSQLSC-GSGECLSAERRCDLRPDCQDGSDE 2495
Score = 45.8 bits (107), Expect = 0.001
Identities = 73/313 (23%), Positives = 108/313 (34%), Gaps = 66/313 (21%)
Query: 4159 LCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQP 4218
+C+ P P C CP G+ L NGTCVP PT P C G L +
Sbjct: 4843 ICVQEPCQPGCGCPGGQLLHNGTCVP---PTACP-------CTQHSLPWG---LTLTLEE 4889
Query: 4219 KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCT-------QQV 4271
+ + P T +C H GG + S + C+ P G T + +Q
Sbjct: 4890 QAQELPPGTVLTRNCTRCVCH---GGAFSCS---LVDCQVPPGETWQQVAPGELGLCEQT 4943
Query: 4272 CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC--SGYCENFGTCQMAADGS---R 4326
C A + + C C PG R Q C +CE + + GS
Sbjct: 4944 CLEMNATKTQSNCSSARASGCVCQPGHF--RSQAGPCVPEDHCECWHLGRPHLPGSEWQE 5001
Query: 4327 QCRCTAYFEGSRCEVNKCS--RCLEGACVVNKQSGDVTCNC---TDGRVAPSCL------ 4375
C G CS C +G +V + G +C +PSC
Sbjct: 5002 ACESCLCLSGRPVCTQHCSPLTCAQGEEMV-LEPGSCCPSCRREAPEEQSPSCQLLTELR 5060
Query: 4376 -----TC------VGHCSNGGSCTMNSKMMPE-------CQCPPHMTGPRCEEHVFSQQ- 4416
TC V +CS G C ++ +MPE C C + P + + +
Sbjct: 5061 NFTKGTCYLDQVEVSYCS--GYCPSSTHVMPEEPYLQSQCDCCSYRLDPESPVRILNLRC 5118
Query: 4417 QPGHIASILIPLL 4429
GH +++P++
Sbjct: 5119 LGGHTEPVVLPVI 5131
Score = 44.3 bits (103), Expect = 0.003
Identities = 106/468 (22%), Positives = 155/468 (33%), Gaps = 91/468 (19%)
Query: 2611 RCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDC---SSYFRLGVKGVLFQPCE-----R 2662
R G + CN C +NC+ C + + QPC R
Sbjct: 3375 RHHPGARLARPDGCNH---CTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSR 3431
Query: 2663 TSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACP-SGRCIPMS-WTCDKEDD 2720
+ C P+ GA G+ + +R CP +Y CP G P W+
Sbjct: 3432 SRACACPTPQHGGAPCTGEAGEAG--AQHQREACP-SYATCPVDGAWGPWGPWS-----P 3483
Query: 2721 CEHGEDETHCNKFCS-----EAQFEC-----QNHRCISKQWLCDGSDDCGDGSDEAAH-- 2768
C+ ++H ++ CS E C Q+ C C DCG G ++ H
Sbjct: 3484 CDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCT---DCGGG--QSLHPC 3538
Query: 2769 -------CE----GKTCGPSSFSCPGTHVC----VPERWLCDGDKDCA----DGA----- 2804
C+ G C P S C T C + + LC C GA
Sbjct: 3539 GQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPE 3598
Query: 2805 DESIAAGCLYNS--TCDDREFM---CQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCG 2859
++S +AG ++S + + E + C N C+ C DC D S + C
Sbjct: 3599 NQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCS 3658
Query: 2860 PSEFRCANGRCLSSRQWE---CDGENDCHDQSDEAPKNPHCTSQ---EHKCNASSQFL-C 2912
S C G L SR+ C G A ++ C++Q E C A + C
Sbjct: 3659 VS---CGGGEQLRSRRCARPPCPGP---------ARQSRTCSTQVCREAGCPAGRLYREC 3706
Query: 2913 SSGR-CVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGF 2971
G C Q C E GCH E + C Q+C + + + G
Sbjct: 3707 QPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAWLLQ-ELGA 3765
Query: 2972 RLKDDGRTCADVDECSTTFPCSQRCIN---THGSYKCLCVEGYAPRGG 3016
+ D G+ DE + C N HG C + + GG
Sbjct: 3766 TIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADGG 3813
Score = 43.9 bits (102), Expect = 0.004
Identities = 25/96 (26%), Positives = 37/96 (38%), Gaps = 28/96 (29%)
Query: 3709 CLWIGRQCDGTDNCGDGTDEEDCE----------------------------PPTAHTTH 3740
C+ + CDG ++C DG+DE C P +
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRA 2462
Query: 3741 CKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
+ C + CLS+ RC++ DC DGSDE+ C
Sbjct: 2463 LCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 43.1 bits (100), Expect = 0.006
Identities = 31/120 (25%), Positives = 45/120 (37%), Gaps = 11/120 (9%)
Query: 3612 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAW 3671
+C Q C+ C+ CD DC+DGSDE C + P W
Sbjct: 2390 QCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMW---------LPSLPALW 2440
Query: 3672 KCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731
+R +C P++ C + CL R+CD +C DG+DE+ C
Sbjct: 2441 AASTVPFMMPTMALPGLPASRALCSPSQ-LSCGSGE-CLSAERRCDLRPDCQDGSDEDGC 2498
Score = 42.4 bits (98), Expect = 0.011
Identities = 65/279 (23%), Positives = 90/279 (32%), Gaps = 74/279 (26%)
Query: 4156 CEWLCLLSPSG--------PVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNG 4207
C LCL G P CTCP G L N +C+P QC
Sbjct: 2905 CPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLP----------------RSQC--- 2945
Query: 4208 GSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGF-TGPK 4266
C L+ Q +G LD C N TC + + RCP P
Sbjct: 2946 -PCQLHG--------QLYASGAMARLDSC-----NNCTCVSGKMACTSERCPVACGWSPW 2991
Query: 4267 CTQQVCAGYCANNSTCTVNQGNQP-------QCRCLPGFLGDRCQYRQCSGYCENFG--- 4316
+C+ C G P +C+ P + C R C G +G
Sbjct: 2992 TLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQG-PTMEAEFCSLRPCPGPGGEWGPWS 3050
Query: 4317 TCQMAADGSRQCR----CTAYFEGSRCEVNKCSRCLEGACVVNKQ-----SGDVTC---- 4363
C + G + R + E S C + C+ + G C +KQ G +C
Sbjct: 3051 PCSVPCGGGYRNRTRGSSRSLMEFSTCGLQPCAGPVPGMCPRDKQWLDCAQGPASCAELS 3110
Query: 4364 --NCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCP 4400
T+ P C HC + G +N+ +P CP
Sbjct: 3111 APRGTNQTCHPGC-----HCPS-GMLLLNNVCVPTQDCP 3143
Score = 41.2 bits (95), Expect = 0.024
Identities = 34/114 (29%), Positives = 39/114 (34%), Gaps = 12/114 (10%)
Query: 936 CPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWR 995
C P Q C C+ + CD +DC D SDE CA L W
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDER-HCARNLLMWLPSLPAL--------WA 2441
Query: 996 CDNDNDCGDNSDEAGCSHS---CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
G S CS +Q C SG C+ CD DC D SDE
Sbjct: 2442 ASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Score = 40.4 bits (93), Expect = 0.041
Identities = 19/44 (43%), Positives = 22/44 (50%), Gaps = 1/44 (2%)
Query: 3567 EESCTPRP-CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
E P P C CA+G C+ CDG DC DGSDE+ C
Sbjct: 2225 EPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 40.4 bits (93), Expect = 0.041
Identities = 99/473 (20%), Positives = 143/473 (30%), Gaps = 127/473 (26%)
Query: 827 CACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEA 886
C C QVL ++G C+ QPG +C + G
Sbjct: 3344 CYCPPGQVLSSNGAICV-----------QPGHCSCLD--------LLTGQRHHPGARLAR 3384
Query: 887 PALCHQHTCPSDRFKCENNRC-IPNRW-------LCD---------------------GD 917
P C+ TC R C + C +P W +C G
Sbjct: 3385 PDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGG 3444
Query: 918 NDCGNSEDESNATCSARTCPPNQFSCASGRCIPIS-WT-CDLDDDCGDRSDESASCAYPT 975
C E+ A CP G P W+ CD+ C +S S +C+ P
Sbjct: 3445 APCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDM---CLGQSHRSRACSRPP 3501
Query: 976 CFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCD 1035
T GR N C +NS + C+ C Q G+ P
Sbjct: 3502 -------TPEGGRPCPGNH--TQSRPCQENSTQ--CT-DCGGGQSLHPCGQPCP------ 3543
Query: 1036 GDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCI-PLRWRCDGDTDCMDSSDE 1094
C D S + + +P GC Q DGLC+ P RC M +
Sbjct: 3544 --RSCQDLSPGSVCQPGSVGCQPTCGCPLG--QLSQDGLCVPPAHCRCQYQPGAMGIPEN 3599
Query: 1095 KSCEGVTHVCD------PSVKFGCKDSARCISKAWVCDGDNDCEDN------SDEENCES 1142
+S + V G D+ C++ C DC D E+C S
Sbjct: 3600 QSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDC-S 3658
Query: 1143 LAC------------RPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNG 1190
++C RPP A + C ++C + G
Sbjct: 3659 VSCGGGEQLRSRRCARPPCPGPARQSRTC------------------STQVCREAGCPAG 3700
Query: 1191 GCSHNCSVAPGEGIVCSCP-LGMELGPDNHTCQIQSYCAK-----HLKCSQKC 1237
C PGEG SC + ++G + C+ +C + L C Q+C
Sbjct: 3701 RLYRECQ--PGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQEC 3751
Score = 40.0 bits (92), Expect = 0.053
Identities = 23/56 (41%), Positives = 25/56 (44%), Gaps = 8/56 (14%)
Query: 3600 CADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC-----GTG 3650
C GS P C +C SG C+ CD DC DGSDEE C GTG
Sbjct: 2224 CEPGSPP---APLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTG 2276
Score = 39.7 bits (91), Expect = 0.069
Identities = 58/214 (27%), Positives = 72/214 (33%), Gaps = 43/214 (20%)
Query: 4200 CNLQCFNGGSCF--LNARRQPKCRCQPRYTGDKCELDQCWEHC-------RNGGTCAASP 4250
C+LQC GG + P C Q G C++ C E C +GG C
Sbjct: 1271 CSLQC-EGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLLHGGACLEPA 1329
Query: 4251 SGMPTCRCPTG---FTGPKCTQQVCAGYCANNSTCTVNQ----GNQPQCRCLPGFLGDRC 4303
S C C G F Q+ C N TC Q G+ C L +
Sbjct: 1330 S----CPCEWGRNSFPPGSVLQKDCG-----NCTCQEGQWHCGGDGGHCEELVPACAEGE 1380
Query: 4304 QYRQCSGYCENFG-TCQM---AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQS- 4358
Q +G+C G C DGS + C A G CL A + ++Q
Sbjct: 1381 ALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDD 1440
Query: 4359 -GDVTCN-----------CTDGRVAPSCLTCVGH 4380
GD T C DGR P L C GH
Sbjct: 1441 CGDGTDEPSYPCPQGLLACADGRCLPPALLCDGH 1474
Score = 39.7 bits (91), Expect = 0.069
Identities = 65/304 (21%), Positives = 91/304 (29%), Gaps = 64/304 (21%)
Query: 4169 CTCPNGKRLDNGTCVPV---PSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPR 4225
C CP G +G CVP+ + PG+ + N SC Q C QP
Sbjct: 4098 CRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSC---QAGQLSCTAQPC 4154
Query: 4226 YTGDKCELDQCWEHCRNGGTC---------------AASPSGMPTCRCPTGFTGPKCTQQ 4270
C W H C + S S P CR + P C Q
Sbjct: 4155 PPPTHC----AWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQP-CPQP 4209
Query: 4271 VCAGYCANNSTCTV-----NQGNQPQCRCLPGFLGDRCQYRQCS-----GYCENFGTCQM 4320
C C + QG +C C P G C+ +C+ ++ C +
Sbjct: 4210 SCPPLCLQGTRSRTLGDSWLQGECQRCSCTPE--GVICEDTECAVPEAWTLWSSWSDCPV 4267
Query: 4321 AADG-----SRQCRCTAYFEGS--------RCEVNKCSRCLEG-----------ACVVNK 4356
+ G +R CR A S + C LE +C
Sbjct: 4268 SCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPGLLEACSWGPWGPCSRSCGPGL 4327
Query: 4357 QSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQ 4416
S +C C + P+C + H G + EC + RC V QQ
Sbjct: 4328 ASRSGSCPCLMAKADPTCNSTFLHLDTQG--CYSGPCPEECVWSSWSSWTRCSCRVLVQQ 4385
Query: 4417 QPGH 4420
+ H
Sbjct: 4386 RYRH 4389
Score = 38.5 bits (88), Expect = 0.15
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 10/57 (17%)
Query: 3362 HSDEPPDCPEFKCRPGQ----------FQCSTGICTNPAFICDGDNDCQDNSDEANC 3408
HSD P C PG +C++G C CDG DC+D SDE C
Sbjct: 2212 HSDVPLQVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.5 bits (88), Expect = 0.15
Identities = 50/257 (19%), Positives = 71/257 (27%), Gaps = 79/257 (30%)
Query: 4160 CLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPK 4219
CL P P C CP G+ + +G CVP+ S
Sbjct: 4695 CLQGPCRPGCRCPPGQLVQDGRCVPISS-------------------------------- 4722
Query: 4220 CRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANN 4279
CRC G+P+ + Q C N
Sbjct: 4723 CRC-----------------------------GLPSANASWELAPAQAVQLDC-----QN 4748
Query: 4280 STCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYC-----ENFGTCQMAADGSRQCRCTAYF 4334
TC P C LG + CS C E TC+ G C+
Sbjct: 4749 CTCVNESLVCPHQEC--PVLGPWSAWSSCSAPCGGGTMERHRTCE-GGPGVAPCQAQDTE 4805
Query: 4335 EGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMM 4394
+ C + C C G + + +C C + P + C G C +++
Sbjct: 4806 QRQECNLQPCPECPPGQVL---SACATSCPCLCWHLQPGAICVQEPCQPGCGCP-GGQLL 4861
Query: 4395 PECQCPPHMTGPRCEEH 4411
C P P C +H
Sbjct: 4862 HNGTCVPPTACP-CTQH 4877
Score = 38.1 bits (87), Expect = 0.20
Identities = 76/358 (21%), Positives = 113/358 (31%), Gaps = 71/358 (19%)
Query: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDC-PGVKRP--RCPLNYFACPSGRCIPMSWTCD 2716
CE + + C D D C G RP RCP GRC+P+S
Sbjct: 4667 CEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLV-QDGRCVPIS---- 4721
Query: 2717 KEDDCEHGEDETHCNKFCSEAQ---FECQNHRCISKQWLC---------------DGSDD 2758
C G + + + AQ +CQN C+++ +C S
Sbjct: 4722 ---SCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAP 4778
Query: 2759 CGDGSDEAAH-CEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST 2817
CG G+ E CEG GP C +R C+ + C + + + C +
Sbjct: 4779 CGGGTMERHRTCEG---GPGVAPCQAQD--TEQRQECN-LQPCPECPPGQVLSACATSCP 4832
Query: 2818 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCG-PSEFRCANGRCLSSRQW 2876
C +C + Q +C + C+ P CG P NG C+
Sbjct: 4833 C-----LCWHLQ---PGAICVQE-----------PCQ-PGCGCPGGQLLHNGTCVPPTAC 4872
Query: 2877 ECDGEN-------DCHDQSDEAPKNPHCTSQEHKCNA-SSQFLCSSGRCVAEALLCNGQD 2928
C + +Q+ E P T +C F CS C G+
Sbjct: 4873 PCTQHSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLVDCQVPP----GET 4928
Query: 2929 DCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDEC 2986
+ E G CL + +C + C C+PG + C D C
Sbjct: 4929 WQQVAPGELGLCEQTCLEMNATKTQSNCSSARAS-GCVCQPG-HFRSQAGPCVPEDHC 4984
Score = 37.7 bits (86), Expect = 0.26
Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 4/49 (8%)
Query: 2591 CGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
C GS P GVG RC G C+ C+ +DCED SDE C
Sbjct: 2224 CEPGSPPAPL---CPGVG-LRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 37.7 bits (86), Expect = 0.26
Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 15/68 (22%)
Query: 6 LLLLLPLLSALVAAA-------------IDAPKT-CSPKQFACRDQITCISKGWRCDGER 51
LL+ LP L AL AA+ + A + CSP Q +C C+S RCD
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSG-ECLSAERRCDLRP 2487
Query: 52 DCPDGSDE 59
DC DGSDE
Sbjct: 2488 DCQDGSDE 2495
Score = 37.4 bits (85), Expect = 0.34
Identities = 57/241 (23%), Positives = 74/241 (30%), Gaps = 57/241 (23%)
Query: 4168 VCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKC------- 4220
V CP+G G C P+PS PP + PG S +A P C
Sbjct: 1514 VWDCPDGADEGPGHC-PLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRC 1572
Query: 4221 ---RCQPRYTGDKCELDQ--------------CWEH---CRNGGTCAA------------ 4248
C PR G +C+ ++ C H C G C +
Sbjct: 1573 GSGECTPR--GWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCP 1630
Query: 4249 --SPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQ---GNQPQCRCLPGFLGDRC 4303
S G C GP T C Y N TC Q QP C PG +G
Sbjct: 1631 DGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCG-RPGQVGPSP 1689
Query: 4304 QYRQCS--GYCENFGTCQMAA-----DGSRQCRCTAYFEGSRC--EVNKCSRCLEGACVV 4354
+ + C G +G C SR+C C ++ C AC V
Sbjct: 1690 EEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPV 1749
Query: 4355 N 4355
+
Sbjct: 1750 D 1750
Score = 37.4 bits (85), Expect = 0.34
Identities = 23/57 (40%), Positives = 31/57 (54%), Gaps = 9/57 (15%)
Query: 54 PDGSDEAPEICPQSKAQRCQPNEHNC--LGTELCVPMSRLCNGVQDCMDGSDEGPHC 108
P G AP P + C P + C LG CV +++C+G +DC+DGSDE HC
Sbjct: 2376 PAGQSVAPGPFPPVQ---CGPGQTPCEVLG---CVEQAQVCDGREDCLDGSDE-RHC 2425
Score = 36.6 bits (83), Expect = 0.58
Identities = 22/48 (45%), Positives = 25/48 (52%), Gaps = 6/48 (12%)
Query: 2843 CADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
C GS +P C P G RCA+G C+ R CDG DC D SDE
Sbjct: 2224 CEPGSPPAPLC--PGVG---LRCASGECVL-RGGPCDGVLDCEDGSDE 2265
Score = 36.2 bits (82), Expect = 0.76
Identities = 16/37 (43%), Positives = 17/37 (45%)
Query: 2694 PRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC 2730
P CP C SG C+ CD DCE G DE C
Sbjct: 2232 PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 35.8 bits (81), Expect = 1.00
Identities = 58/264 (21%), Positives = 86/264 (32%), Gaps = 56/264 (21%)
Query: 2630 CEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGAND-------CGDY 2682
C+ SD C S+Y R + P +LC +C G + CG +
Sbjct: 790 CDPGSD---CLCPVLSAYARRCAQEGASPPWRNQTLCPV---MCPGGQEYRECAPACGQH 843
Query: 2683 SDERDCPG-----VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEA 2737
+ + G V CPL P G+C+P S C+ G ++ +
Sbjct: 844 CGKPEDCGELGSCVAGCNCPLGLLWDPEGQCVPPSLC-----PCQLG-----ARRYAPGS 893
Query: 2738 QFECQNHRCISKQ---WLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLC 2794
+ +RCI ++ W C A HC PS CP V P L
Sbjct: 894 ATMKECNRCICQERGLWNC-----------TARHC------PSQAFCPRELVYAPGACLL 936
Query: 2795 DGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRD-CADGSDESPEC 2853
D + A+ S AG C + R P C H + +C
Sbjct: 937 TCD---SPSANHSCPAGSTDGCVCPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQEDC 993
Query: 2854 EYPTCGPSEFRCA----NGRCLSS 2873
C ++ C +GRC +S
Sbjct: 994 NVCVCRGRQWHCTGQRRSGRCQAS 1017
Score = 35.8 bits (81), Expect = 1.00
Identities = 51/245 (20%), Positives = 74/245 (30%), Gaps = 37/245 (15%)
Query: 3312 GHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTE-----DDCGDHSDEP 3366
G C CP L + R C + + +N P E CG H +P
Sbjct: 793 GSDCLCPV---LSAYARRCAQEGASPPW--RNQTLCPVMCPGGQEYRECAPACGQHCGKP 847
Query: 3367 PDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRC 3426
DC E C G+ +P C + C P NRC
Sbjct: 848 EDCGELGSCVAGCNCPLGLLWDPEGQCVPPSLC-----PCQLGARRYAPGSATMKECNRC 902
Query: 3427 I---PGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGS 3483
I G++ C R CP P + + C+ ++ C GS
Sbjct: 903 ICQERGLWNCTA----------RHCPSQAFCPRELVYA-PGACLLTCDSPSANHSCPAGS 951
Query: 3484 DEPANCTQMTCGVDEFRCKDSGRCIPA-RWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542
+ C T +DE RC+P C + +E+C+ C Q+
Sbjct: 952 TDGCVCPPGTVLLDE-------RCVPPDLCPCRHSGQWYLPNATIQEDCNVCVCRGRQWH 1004
Query: 3543 CKNNR 3547
C R
Sbjct: 1005 CTGQR 1009
Score = 35.8 bits (81), Expect = 1.00
Identities = 16/40 (40%), Positives = 18/40 (45%)
Query: 846 PSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDE 885
P P P C CA+ C+ CDG DC D SDE
Sbjct: 2226 PGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 35.0 bits (79), Expect = 1.7
Identities = 59/265 (22%), Positives = 80/265 (30%), Gaps = 74/265 (27%)
Query: 931 CSARTCP-PNQFSCASGRCIPISWTCDLDDDCGD-RSDESASCAYPTCFPLTQFTCNNGR 988
C+ R CP P +S R P SW D CG +S S SC+ P NG
Sbjct: 3996 CNLRACPVPGGWS----RWSPWSWC---DRSCGGGQSLRSRSCSSPPS--------KNGG 4040
Query: 989 CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRC------IPEHWTCDGDNDCGD 1042
R C EAGC + + + RC + E C D C
Sbjct: 4041 APCAGER-HQARLCNPMPCEAGCP---AGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQK 4096
Query: 1043 YSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTH 1102
GC + DG C+P+ G DC D+ G H
Sbjct: 4097 ------------------GCRCPKGSLEQDGGCVPI-----GHCDCTDAQGHSWAPGSQH 4133
Query: 1103 VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPP 1162
D N+C + + +C + C PP+H ++ S P
Sbjct: 4134 Q----------------------DACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSAWSPC 4171
Query: 1163 DKLCD--GNDDCGDGSDEGELCDQC 1185
C G S G +C
Sbjct: 4172 SHSCGPRGQQSRFRSSTSGSWAPEC 4196
Score = 34.3 bits (77), Expect = 2.9
Identities = 17/45 (37%), Positives = 18/45 (40%)
Query: 3536 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEF 3580
C RC + CV CD DC D SDEE C P F
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRF 2278
Score = 34.3 bits (77), Expect = 2.9
Identities = 14/26 (53%), Positives = 18/26 (69%)
Query: 2532 CANGECINFSLTCDGVPHCKDKSDEK 2557
CA+GEC+ CDGV C+D SDE+
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEE 2266
Score = 34.3 bits (77), Expect = 2.9
Identities = 73/286 (25%), Positives = 101/286 (35%), Gaps = 71/286 (24%)
Query: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKP------------SYCNSRRC--KKTFRQ-- 2572
+ C +GEC++ CD P C+D SDE S C SR C TF++
Sbjct: 2468 QLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSC-SRSCGLGLTFQRQE 2526
Query: 2573 ----------CSNGRCVSNMLW---CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIG 2619
C R S + C A PC+ +CG G + R +C+
Sbjct: 2527 LLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCS-VSCG-GGHQSRQRSCVD 2584
Query: 2620 NSSRCNQFVDCEDASDE-MNCSATDCS--SYFRLGVKGVLFQPCERTSLCYAPSWVCDGA 2676
+ N C AS E C CS + LG V C++ + P
Sbjct: 2585 PPPK-NGGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPP------ 2637
Query: 2677 NDCGDYSDERDCPG--VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDET------ 2728
C D R C G V+ RCP + RC+P+S E C GE+
Sbjct: 2638 -SCLDPKANRSCSGHCVEGCRCPPGLLLHDT-RCLPLS-----ECPCLVGEELKWPGVSF 2690
Query: 2729 ---HCNK-FCSEAQFECQNHRC-------ISKQWL-CDGSDDCGDG 2762
+C++ C + + CQ C W CD S CG G
Sbjct: 2691 LLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRS--CGSG 2734
Score = 33.9 bits (76), Expect = 3.8
Identities = 22/52 (42%), Positives = 24/52 (46%), Gaps = 10/52 (19%)
Query: 53 CPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
C GS AP +CP RC E CV C+GV DC DGSDE
Sbjct: 2224 CEPGSPPAP-LCP-GVGLRCASGE--------CVLRGGPCDGVLDCEDGSDE 2265
Score = 33.9 bits (76), Expect = 3.8
Identities = 119/520 (22%), Positives = 164/520 (31%), Gaps = 100/520 (19%)
Query: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQF------QCSTGICT 3387
C+ SQ C + +C+ +CD DC D SDE C + P C G+
Sbjct: 2464 CSPSQLSCGSGECLSAERRCDLRPDCQDGSDE-DGCVDCVLAPWSVWSSCSRSCGLGLTF 2522
Query: 3388 NPAFI----CDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNG-----QDN 3438
+ G + +D +C + C P P C G Q +
Sbjct: 2523 QRQELLRPPLPGGSCPRDRFRSQSCFVQAC-PVAGAWAMWEAWGPCSVSCGGGHQSRQRS 2581
Query: 3439 CGDGEDER---DCPEVT--CAPNQFQ-CSITKRC-IPRVWV----CDRD--NDCVDGSDE 3485
C D + CP + AP Q CS C + RV+V C + C +
Sbjct: 2582 CVDPPPKNGGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLD 2641
Query: 3486 P-ANCTQMTCGVDEFRCK-----DSGRCIPARWKCD---GEDDCGDGSDEPKEECDERTC 3536
P AN + V+ RC RC+P +C GE+ G C + C
Sbjct: 2642 PKANRSCSGHCVEGCRCPPGLLLHDTRCLPLS-ECPCLVGEELKWPGVSFLLGNCSQCVC 2700
Query: 3537 EPYQFRCKNNRC-VPGRWQ-----CDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAG 3590
E + C+ C +P W D CG +P S + C
Sbjct: 2701 EKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSP---SNPPAAWGGAPCEGD 2757
Query: 3591 RWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIP---LRWR-----CDADADCM--- 3639
R + G H G++ TP C P WR C + D
Sbjct: 2758 RQELQGCHTVC-GTEVFGWTPWTSWS--SCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPG 2814
Query: 3640 DGSDEEACGTGV-------------RTC--PLD-EFQCNNTLCKPLAWKCDGEDDC---- 3679
D + EE C V TC P D Q C LA G+ C
Sbjct: 2815 DATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLA---PGDTTCPGPH 2871
Query: 3680 GDNSDENPEECARFVCPPNRPFR----CKND-----RVCLWIGRQCDGTDNCGDGTDEED 3730
D N + C CP N FR C + R+CL G + T C G
Sbjct: 2872 SQTRDCNTQPCTA-QCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGC---T 2927
Query: 3731 CEPPT-AHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGD 3769
C P H C + + C+ L +S D C +
Sbjct: 2928 CPPGLFLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNN 2967
Score = 33.9 bits (76), Expect = 3.8
Identities = 53/247 (21%), Positives = 74/247 (29%), Gaps = 59/247 (23%)
Query: 3486 PANCTQMTCGV---DEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542
P C+ + G+ D+ C+ RC + DG P CD + + +
Sbjct: 4076 PRRCSDLQEGIVCQDDQVCQKGCRCPKGSLE-------QDGGCVPIGHCDCTDAQGHSW- 4127
Query: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKC--DGDHDC 3600
PG D N+C + + SCT +PC C W H C
Sbjct: 4128 ------APGSQHQDACNNCSCQAGQLSCTAQPCPPPT------HCAWSHWSAWSPCSHSC 4175
Query: 3601 AD--------GSDEKDCTPRCDMDQFQ---CKSGHCIPLRWRCDADADCMDGSDEEACGT 3649
S P C +Q Q C C PL C+ G+ G
Sbjct: 4176 GPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPL---------CLQGTRSRTLGD 4226
Query: 3650 GVR-------TCPLDEFQCNNTLCK-PLAWK-----CDGEDDCGDNSDENPEECARFVCP 3696
+C + C +T C P AW D CG + C R P
Sbjct: 4227 SWLQGECQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRAC-RAAAP 4285
Query: 3697 PNRPFRC 3703
+R C
Sbjct: 4286 HHRSPPC 4292
Score = 33.5 bits (75), Expect = 5.0
Identities = 66/275 (24%), Positives = 89/275 (32%), Gaps = 59/275 (21%)
Query: 4158 WLCLLSPSGPVCTCPNGKRLDNGTCV-PVPSPT-------PPPDAPRPGTCNLQC----- 4204
W C + C CP G L G C+ P P PP + N C
Sbjct: 1301 WHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQW 1360
Query: 4205 ---FNGGSC--FLNARRQPKCRCQPR----YTGDKCE-LDQCWEHCRNGGTCAASPSGMP 4254
+GG C + A + + CQ G C+ D C + G CAA G
Sbjct: 1361 HCGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEG-CAAPGCGEG 1419
Query: 4255 TCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC---SGY 4311
C +G P A C C + ++P C G L C +C +
Sbjct: 1420 QMTCSSGHCLP------LALLCDRQDDCG-DGTDEPSYPCPQGLLA--CADGRCLPPALL 1470
Query: 4312 CENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVA 4371
C+ C AAD + C EV+ C++G C+ Q D +C DG
Sbjct: 1471 CDGHPDCLDAAD---EESCLGQVTCVPGEVS----CVDGTCLGAIQLCDGVWDCPDGADE 1523
Query: 4372 PSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGP 4406
GHC +P PP T P
Sbjct: 1524 GP-----GHCP-----------LPSLPTPPASTLP 1542
Score = 33.1 bits (74), Expect = 6.5
Identities = 17/42 (40%), Positives = 18/42 (42%)
Query: 933 ARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYP 974
A CP CASG C+ CD DC D SDE P
Sbjct: 2231 APLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLP 2272
Score = 33.1 bits (74), Expect = 6.5
Identities = 67/294 (22%), Positives = 85/294 (28%), Gaps = 86/294 (29%)
Query: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDND 3560
C D G C D C P C ++ R + + G
Sbjct: 4606 CPDPGAC---------PDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCG-------GG 4649
Query: 3561 CGDNSDEESCTPRPCSESE-------FSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-- 3611
C + +ESC PC E E CAN +C H CAD D C
Sbjct: 4650 CREPWAQESCNGGPCPECEAQDTVFTLDCAN-QC---------PHSCADLWDRVQCLQGP 4699
Query: 3612 -----RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVR------TCPLDEFQ 3660
RC Q + G C+P+ C + S E A V+ TC +
Sbjct: 4700 CRPGCRCPPGQL-VQDGRCVPIS-SCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLV 4757
Query: 3661 CNNTLCKPL----AWK----------------CDGED---DCGDNSDENPEECARFVCPP 3697
C + C L AW C+G C E +EC CP
Sbjct: 4758 CPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPE 4817
Query: 3698 NRPFR----CKNDRVCL-W--------IGRQCDGTDNCGDG--TDEEDCEPPTA 3736
P + C CL W + C C G C PPTA
Sbjct: 4818 CPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTA 4871
Score = 32.7 bits (73), Expect = 8.4
Identities = 18/42 (42%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 3485 EPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526
EP + C RC SG C+ CDG DC DGSDE
Sbjct: 2225 EPGSPPAPLCPGVGLRCA-SGECVLRGGPCDGVLDCEDGSDE 2265
Score = 32.7 bits (73), Expect = 8.4
Identities = 15/35 (42%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 3697 PNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731
P RC + C+ G CDG +C DG+DEE C
Sbjct: 2235 PGVGLRCASGE-CVLRGGPCDGVLDCEDGSDEEGC 2268
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 179 bits (453), Expect = 7e-44
Identities = 162/599 (27%), Positives = 241/599 (40%), Gaps = 112/599 (18%)
Query: 2794 CDGDKDCADGADESIAAGCLYN-----STCDDREFMCQNRQCIPKHFVCDHDRDCADGSD 2848
CD + C G C TC D + + H +C++
Sbjct: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH-------- 730
Query: 2849 ESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASS 2908
P FRC C+ Q+ +G C D+ P N +C + H C+
Sbjct: 731 -----------PGTFRC---ECVEGYQFSDEGT--CVAVVDQRPIN-YCETGLHNCDIPQ 773
Query: 2909 QFLCSSGRCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGCSQD--CEDLKIGFKC 2965
+ C + C G S D + C ++EC + S C D C + F C
Sbjct: 774 RAQCIYTGGSSYTCSCLP----GFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTC 826
Query: 2966 RCRPGFRLKDDGRTCADVDECSTTFPCSQRCI----------------------NTHGSY 3003
+C+PG++ DG C + T + I + HG Y
Sbjct: 827 QCKPGYQ--GDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHY 884
Query: 3004 K----------CLCV-------EGYAPRGGDPHSC---------------KAVTDEEP-- 3029
C CV EG R G C AV P
Sbjct: 885 APTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGT 944
Query: 3030 FLIFANRYYLRKLNLDGSNY------TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
L+FA + +L L+G+ L + L FD ++M+YWTD+T I
Sbjct: 945 HLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS--I 1002
Query: 3084 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG 3143
R L+G + R L +P+G+AVD +G N++W D D IEV+KL+G R VL +
Sbjct: 1003 GRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETD 1062
Query: 3144 LREPRALVVDVQNGYLYWTDWG-DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTER 3202
L PR +V D G LYWTDW D+ I MDG++R ++V + PNGLT D + +
Sbjct: 1063 LVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQ 1122
Query: 3203 IYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
+ W DA + E + +R L + + + FA+T + +Y+TDW+ S+
Sbjct: 1123 LCWVDAGTNRAECLNPSQPSRRKAL-EGLQYPFAVTSYGKNLYFTDWKMNSV--VALDLA 1179
Query: 3263 TNKTLLISTLHRPMDLH-VFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTN 3320
+K H+ L+ + AL Q ++ C VNNGGC++LCL +P G C CP N
Sbjct: 1180 ISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATP-GSRTCRCPDN 1237
Score = 162 bits (410), Expect = 7e-39
Identities = 97/268 (36%), Positives = 136/268 (50%), Gaps = 14/268 (5%)
Query: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
I L F +YWTD+ E I R L T +I+ L +PEG+AVD + NI+
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTT----IIRQDLGSPEGIAVDHLGRNIF 1036
Query: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
W +SNLD+IEVAKLDGT R L D+ +PR I D G L+WTDW+ P+IE + M
Sbjct: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
Query: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
G RR + ++ G PNGLT D ++ W+DA ++ + L G L
Sbjct: 1097 GTNRRILVQD--DLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQ 1151
Query: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ-RTNTQPFDLQVYHPSRQPMAPN 1538
+PFAVT YG +Y+TDW+ N++ + Q T+ + + S+ P N
Sbjct: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT-ALSQCPQGHN 1210
Query: 1539 PCEANGGQGPCSHLCLINYNRTVSCACP 1566
C N G C+HLCL + +C CP
Sbjct: 1211 YCSVN--NGGCTHLCLATPG-SRTCRCP 1235
Score = 161 bits (407), Expect = 2e-38
Identities = 99/280 (35%), Positives = 152/280 (54%), Gaps = 18/280 (6%)
Query: 564 LDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP 623
L F +Y+ D T IGR + G E TI++ + + EG+AVD +G N++WTD
Sbjct: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNL 1042
Query: 624 KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAW 683
+ I VA+L+ R+ L E + +PR IV D + G +YWTDW D ++E ++
Sbjct: 1043 DR-IEVAKLD--GTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRD-----NPKIETSY 1094
Query: 684 MDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELN 743
MDG++R I V L PNGL+ D + +L WVDA +R E + + R+ EG L
Sbjct: 1095 MDGTNRRILVQDDLGL-PNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG--LQ 1151
Query: 744 HAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVG 803
+ F + +G L++T+++ SV L+ + + T ++ ++ I +Q Q G
Sbjct: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAI--SKETDAFQPHKQTRLYGITTALSQCPQ-G 1208
Query: 804 TNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCL 843
N C VNNGGC+ LCLATPGSR C C ++ + GV C+
Sbjct: 1209 HNYCSVNNGGCTHLCLATPGSRTCRCPDNTL----GVDCI 1244
Score = 138 bits (347), Expect = 1e-31
Identities = 98/333 (29%), Positives = 154/333 (46%), Gaps = 16/333 (4%)
Query: 1868 TRSCMCTAGYSLRSGQQACEGV-----GSFLLYSVHEGIRGIPLDPND----KSDALVPV 1918
T C+ T + G V G+ LL++ I +PL+ N ++ A + V
Sbjct: 916 TPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHV 975
Query: 1919 SGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGN 1978
+ +G+ F + +YW D+ +I RA ++ +G EGIAVD + N
Sbjct: 976 PA-KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRN 1034
Query: 1979 IYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ-YPRIERSR 2037
I+WTD D IEVA+L+G+ R V+ L PR I +G L+WT+W + P+IE S
Sbjct: 1035 IFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSY 1094
Query: 2038 LDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMD 2097
+DGT R +LV + PNG++ D +L W DA T++ E ++ R+ +
Sbjct: 1095 MDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKAL--EGLQY 1152
Query: 2098 MFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTN 2157
F+V+ + +Y++D + + TD+ + +L I +G N
Sbjct: 1153 PFAVTSYGKNLYFTDWKMNSVVALDLAISKETDA--FQPHKQTRLYGITTALSQCPQGHN 1210
Query: 2158 VCAVANGGCQQLCLYRGRGQRACACAHGMLAED 2190
C+V NGGC LCL G R C C L D
Sbjct: 1211 YCSVNNGGCTHLCL-ATPGSRTCRCPDNTLGVD 1242
Score = 125 bits (315), Expect = 7e-28
Identities = 89/278 (32%), Positives = 126/278 (45%), Gaps = 51/278 (18%)
Query: 3914 VYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVY 3973
VYWT+ +I SL P T + L P GIA+D + N++
Sbjct: 992 VYWTDITEPSIGRASLHGGEPTTIIRQD---------------LGSPEGIAVDHLGRNIF 1036
Query: 3974 WTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG-NHPKIETAAMD 4032
WTDS D IEVA++ G R+ L + P IV D +RG +YW+DW ++PKIET+ MD
Sbjct: 1037 WTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMD 1096
Query: 4033 GTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSK--RGLS 4090
GT R LVQD++ P GL D + +L W DA G+ R +P + K GL
Sbjct: 1097 GTNRRILVQDDLGLPNGLTFDAFSSQLCWVDA-----GTNRAECLNPSQPSRRKALEGLQ 1151
Query: 4091 HPFSIDVFEDYIYGVTYINNRV-------------FKIHKFGHSPLVNLTGGLSHASDVV 4137
+PF++ + +Y + N V F+ HK + L +T LS
Sbjct: 1152 YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHK--QTRLYGITTALSQC---- 1205
Query: 4138 LYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPN 4173
P+ N C + C LCL +P C CP+
Sbjct: 1206 -------PQGHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
Score = 121 bits (303), Expect = 2e-26
Identities = 85/265 (32%), Positives = 134/265 (50%), Gaps = 24/265 (9%)
Query: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDT 1679
L +D ++ VYW+D+ +I RA ++G T++ DL + G+AVD + RN+FWT D+
Sbjct: 983 LAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWT--DS 1040
Query: 1680 NKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWT----DGDNISMANMDGSNR 1734
N +I VA+LDG+ + + + L P G+V +RG LYWT D I + MDG+NR
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 1735 TLLFSGQKG-PVGLAIDFPESKLYWISSGNHTINRCN-LDGSGLEVIDAMRSQLGKATAL 1792
+L G P GL D S+L W+ +G + N S + ++ ++ A+
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPF----AV 1156
Query: 1793 AIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMH--MKVYDESIQLDH--KGTN 1848
G L++ D KM + D + + + H ++Y + L +G N
Sbjct: 1157 TSYGKNLYFTDW---KMNSVVALD---LAISKETDAFQPHKQTRLYGITTALSQCPQGHN 1210
Query: 1849 PCSVNNGDCSQLCLPTSETTRSCMC 1873
CSVNNG C+ LCL T +R+C C
Sbjct: 1211 YCSVNNGGCTHLCLAT-PGSRTCRC 1234
Score = 103 bits (258), Expect = 3e-21
Identities = 74/276 (26%), Positives = 125/276 (45%), Gaps = 23/276 (8%)
Query: 2234 KNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIV-ENVGSVEGLAYHR 2292
K +I LAFD ++++DI +I + + G TI+ +++GS EG+A
Sbjct: 978 KVIIGLAFDC-------VDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH 1030
Query: 2293 GWDTLYWTSYTTSTITRHTVDQT-RPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNW 2351
++WT I +D T R FE + V +PR V D + ++WT+W
Sbjct: 1031 LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLV-------NPRGIVTDSVRGNLYWTDW 1083
Query: 2352 NEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2411
N +P I + + G N L++ D+ PNGL D + +L + DA ++ E R
Sbjct: 1084 NRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSR 1143
Query: 2412 YVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA 2471
L+ +PF + YG+++++TDW +V + + + P + + +
Sbjct: 1144 RKALEGLQ-YPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQ---PHKQTRLYGIT 1199
Query: 2472 NDTNSCEL--SPCRINNGGCQDLCLLTHQGHVNCSC 2505
+ C + C +NNGGC LCL T G C C
Sbjct: 1200 TALSQCPQGHNYCSVNNGGCTHLCLAT-PGSRTCRC 1234
Score = 89.0 bits (219), Expect = 1e-16
Identities = 114/480 (23%), Positives = 185/480 (38%), Gaps = 52/480 (10%)
Query: 56 GSDEAPEICPQSKAQRCQPNE--HNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRE--- 110
G +A + + + RC P+ +N G+ C C+ G E C+
Sbjct: 795 GDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHERE 854
Query: 111 -LQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ-LQADGKT----CKDFDECSVYGTCSQLC 164
+ G Q P L P C + + Q G T C D D V GT
Sbjct: 855 HILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGT----- 909
Query: 165 TNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV--LLIANSQNILATYLSG-----A 217
T C+ + P ++ + PP LL A + I L G
Sbjct: 910 -RTRPGMTPPCLST-VAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
Query: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISL 277
+ + + F ++ V W + + + A + G E T I
Sbjct: 968 EAKAFLHVPAKVIIGLAFDCVDKMVYWTDI----TEPSIGRASLHG-----GEPTTIIRQ 1018
Query: 278 SLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKV 337
L E +A+D L N ++ D DRI V +G L + +L NP+GI D G +
Sbjct: 1019 DLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNL 1078
Query: 338 FFTDYGQ-IPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDY 396
++TD+ + PK+E MDG NR LV + P+G+T D S + W DA + E ++
Sbjct: 1079 YWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNP 1138
Query: 397 EGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRV 456
R+ ++G +++ + +T + LY T+ + SV+ ++ S E
Sbjct: 1139 SQPSRRKALEG--LQYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPH 1190
Query: 457 DKGGALHIYHQRRQ-PRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSD 515
+ I Q P+ ++ N+ GGC+ +CL +RTCRC +LG D
Sbjct: 1191 KQTRLYGITTALSQCPQGHNYCSVNN-----GGCTHLCLATPG--SRTCRCPDN-TLGVD 1242
Score = 57.8 bits (138), Expect = 2e-07
Identities = 30/109 (27%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Query: 1613 DIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNL 1672
D+ + + D + ++W+D I+ A ++GT + DL N G+ D V NL
Sbjct: 1019 DLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNL 1078
Query: 1673 FWTSYDTNKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWTD 1720
+WT ++ + +I + +DG+ + +VQ L P+GL +L W D
Sbjct: 1079 YWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVD 1127
Score = 50.4 bits (119), Expect = 4e-05
Identities = 43/121 (35%), Positives = 55/121 (45%), Gaps = 25/121 (20%)
Query: 91 LCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHH--CVPTLDGP----TCYCNSSFQLQ 142
L N + +GS + LQ C GC + C P GP TC C+ F+
Sbjct: 653 LSNSIGPVREGSPDA-----LQNPCYIGTHGCDTNAACRP---GPRTQFTCECSIGFR-- 702
Query: 143 ADGKTCKDFDECSVY-GTCSQ--LCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPP 199
DG+TC D DECS C +C N G+F C CVEGY D +C A VD+ P
Sbjct: 703 GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFS-DEGTCVA---VVDQRP 758
Query: 200 V 200
+
Sbjct: 759 I 759
Score = 50.1 bits (118), Expect = 5e-05
Identities = 55/175 (31%), Positives = 68/175 (38%), Gaps = 23/175 (13%)
Query: 22 DAPKTCSPKQFACRDQITC-ISKGWRCDGERDCPDGSD--EAPEICPQSKAQRCQPNEHN 78
D C P R Q TC S G+R DG R C D + E P +C P
Sbjct: 680 DTNAACRPGP---RTQFTCECSIGFRGDG-RTCYDIDECSEQPSVCGSHTICNNHPGTFR 735
Query: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGP--HCRELQGNCSRLGCQHHCVPTLDGP-TCYC 135
C CV + + C+ D+ P +C NC + + C+ T TC C
Sbjct: 736 CE----CVEGYQFSDE-GTCVAVVDQRPINYCETGLHNCD-IPQRAQCIYTGGSSYTCSC 789
Query: 136 NSSFQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGYLLQPDNRSC 188
F DG+ C+D DEC C C NT GSF C C GY Q D C
Sbjct: 790 LPGFS--GDGQACQDVDECQP-SRCHPDAFCYNTPGSFTCQCKPGY--QGDGFRC 839
Score = 47.0 bits (110), Expect = 4e-04
Identities = 50/180 (27%), Positives = 65/180 (36%), Gaps = 45/180 (25%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGD--KC-ELDQCWEH---CRNGGTCAASPSGMPTCR 4257
C +C R Q C C + GD C ++D+C E C + C P G C
Sbjct: 679 CDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP-GTFRCE 737
Query: 4258 CPTGF------TGPKCTQQVCAGYCANN---------STCTVNQGNQPQCRCLPGFLG-- 4300
C G+ T Q YC + C G+ C CLPGF G
Sbjct: 738 CVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDG 797
Query: 4301 ------DRCQYRQC--SGYCENFGTCQMAADGSRQCRCTAYFEGS--RC---EVNKCSRC 4347
D CQ +C +C N GS C+C ++G RC EV K +RC
Sbjct: 798 QACQDVDECQPSRCHPDAFCYN-------TPGSFTCQCKPGYQGDGFRCVPGEVEK-TRC 849
Score = 43.9 bits (102), Expect = 0.004
Identities = 49/206 (23%), Positives = 68/206 (33%), Gaps = 53/206 (25%)
Query: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC--VSNCTASQFVCKND 3344
PD +PC + GC PG + C + DGRTC + C+ VC +
Sbjct: 665 PDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSH 724
Query: 3345 KCI---PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3401
P ++C+ + SDE RP + C TG+
Sbjct: 725 TICNNHPGTFRCECVEGY-QFSDEGTCVAVVDQRPINY-CETGL---------------- 766
Query: 3402 NSDEANCDIHVCLPSQFKCTNTN------RCIPGIF----RCNGQDNCGDGEDERDCPEV 3451
NCDI P + +C T C+PG C D C + R P+
Sbjct: 767 ----HNCDI----PQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDA 815
Query: 3452 TC--APNQFQCSITK-------RCIP 3468
C P F C RC+P
Sbjct: 816 FCYNTPGSFTCQCKPGYQGDGFRCVP 841
Score = 37.0 bits (84), Expect = 0.45
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 12/151 (7%)
Query: 1699 QGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSN------RTLLFSGQKGPVGLAIDFP 1752
QG P ++ P L + I ++G+ + L K +GLA D
Sbjct: 929 QGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
Query: 1753 ESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAI--MGDKLWWADQVSEKMG 1810
+ +YW +I R +L G E +R LG +A+ +G ++W D +++
Sbjct: 989 DKMVYWTDITEPSIGRASLHGG--EPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRI- 1045
Query: 1811 TCSKADGSGSVVLRNSTTLVMHMKVYDESIQ 1841
+K DG+ VL T LV + +S++
Sbjct: 1046 EVAKLDGTQRRVL-FETDLVNPRGIVTDSVR 1075
Score = 36.6 bits (83), Expect = 0.58
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 1185 CSLNNGGCSHNCSVAPGEGIVCSCP 1209
CS+NNGGC+H C PG C CP
Sbjct: 1212 CSVNNGGCTHLCLATPGSR-TCRCP 1235
Score = 36.2 bits (82), Expect = 0.76
Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 4/95 (4%)
Query: 1174 DGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK- 1232
+GS + L + C + GC N + PG +C + D TC C++
Sbjct: 662 EGSPDA-LQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV 720
Query: 1233 CSQK--CDQNKFSVKCSCYEGWVLEPDGESCRSLD 1265
C C+ + + +C C EG+ +G +D
Sbjct: 721 CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVD 755
Score = 35.8 bits (81), Expect = 1.00
Identities = 23/109 (21%), Positives = 43/109 (39%), Gaps = 16/109 (14%)
Query: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
G +YWT+W+ R P +RR + + L +P G+ D +
Sbjct: 1076 GNLYWTDWN------RDNPKIETSYMDGTNRRILVQ-------DDLGLPNGLTFDAFSSQ 1122
Query: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW 4020
+ W D+G + E +R+ + G+ + V +Y++DW
Sbjct: 1123 LCWVDAGTNRAECLNPSQPSRRKALEGL---QYPFAVTSYGKNLYFTDW 1168
Score = 33.1 bits (74), Expect = 6.5
Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 30/156 (19%)
Query: 813 GCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFAC---ANSRCIQ- 868
G ++C PG+ +C C E +G TC+A P C+ G C ++CI
Sbjct: 722 GSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRAQCIYT 780
Query: 869 --ERWKC------DGDNDCLDNSDEA-PALCH----------QHTCP-SDRFKCENNRCI 908
+ C GD + DE P+ CH TC ++ + RC+
Sbjct: 781 GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV 840
Query: 909 P---NRWLCDGDNDCGNSEDESNATCSARTCPPNQF 941
P + C + + + + AT R PP F
Sbjct: 841 PGEVEKTRCQHERE--HILGAAGATDPQRPIPPGLF 874
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 176 bits (446), Expect = 5e-43
Identities = 92/242 (38%), Positives = 130/242 (53%), Gaps = 5/242 (2%)
Query: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127
E +YWTD IRR +L+GS Q L T +++PD +AV+WV +LYW G + IE
Sbjct: 2 EGHVYWTDDEVWA--IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK 3187
V+ LN +LVS + EPRA+ + + G YW DWG++ I R +D V+V+
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 3188 ITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWT 3247
+ WPNGL LD ++YW DA+ D IE S+D + R +L +PHIF TL D++YWT
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 3248 DWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLL 3307
W+ SI R HK N+ ++I L M L + V +P NGG +
Sbjct: 180 AWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNV--DKVVGTNPHADRNGGAATCASS 236
Query: 3308 SP 3309
P
Sbjct: 237 RP 238
Score = 173 bits (438), Expect = 4e-42
Identities = 92/235 (39%), Positives = 136/235 (57%), Gaps = 15/235 (6%)
Query: 1936 IYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLN 1995
+YW D + I RA D + + ++ I + IAV+W+A ++YWT G + IEV LN
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1996 GSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPN 2055
+ +++S+ +D+PRAI +HPE G +W +WG+ P I+R+ LD E VLVN S+ WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 2056 GISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTH 2115
G+++D Q+GKLYW DA+TDKIE I ++ R+ +L +F ++ DFIYW+ H
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 2116 ANGSIKR-----GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGG 2165
SIKR ++D D +P L +K N D+ GTN A NGG
Sbjct: 184 --HSIKRVHKVKANRDVIIDQLP-------DLMGLKAVNVDKVVGTNPHADRNGG 229
Score = 124 bits (311), Expect = 2e-27
Identities = 75/252 (29%), Positives = 133/252 (52%), Gaps = 16/252 (6%)
Query: 571 GFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVA 630
G +Y+ D + I R +DG+ +T++ I++ + +AV+W+ +LYWT G + I V
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH-IEVT 61
Query: 631 RLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRD 690
L + K L+ M PRAI + P G YW DW E+P+ ++RA +D
Sbjct: 62 CLNSTSH--KILVSEDMDEPRAIALHPEMGLTYWIDWGENPE------IKRANLDRQELR 113
Query: 691 IFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCH 750
+ V + ++ WPNGL+LD+ G+LYW DA D+IE I ++ T R+ + + +L H F
Sbjct: 114 VLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTL 171
Query: 751 HGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN 810
G++++WT ++ S+ R+ + ++ + P + ++ + + VGTN
Sbjct: 172 LGDFIYWTAWQHHSIKRVHK----VKANRDVIIDQLPDLMGLKAVNV-DKVVGTNPHADR 226
Query: 811 NGGCSSLCLATP 822
NGG ++ + P
Sbjct: 227 NGGAATCASSRP 238
Score = 121 bits (304), Expect = 1e-26
Identities = 72/240 (30%), Positives = 122/240 (50%), Gaps = 10/240 (4%)
Query: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
+YWTD I R L +GA T +I + P+ +AV+W+A ++YW + + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQT----LINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1371 AKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRET 1430
L+ T L++ D++ PRAIAL P G+ +W DW + P I+ A++ R +
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVL--VN 117
Query: 1431 GSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGE 1490
S GWPNGL +D E ++ W DA++D I + D + +L+ + L H F TL G
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
Query: 1491 VYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCS 1550
+YWT W+ +++ + +K + ++ + L+ + + + NGG C+
Sbjct: 176 IYWTAWQHHSIKRVHKVKANRDVIIDQL-PDLMGLKAVNVDKVVGTNPHADRNGGAATCA 234
Score = 119 bits (298), Expect = 7e-26
Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
G VYWT+ I L + T N + + P IA++WVA +
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLIN---------------TKINDPDDIAVNWVARS 47
Query: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAM 4031
+YWT +G + IEV + + K L+S +DEP AI + P G YW DWG +P+I+ A +
Sbjct: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
Query: 4032 DGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSH 4091
D LV ++ WP GLA+D +LYW DAK I +I ++ T K L H
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPH 165
Query: 4092 PFSIDVFEDYIYGVTYINNRVFKIHK 4117
F + D+IY + ++ + ++HK
Sbjct: 166 IFRFTLLGDFIYWTAWQHHSIKRVHK 191
Score = 107 bits (267), Expect = 3e-22
Identities = 68/235 (28%), Positives = 119/235 (50%), Gaps = 13/235 (5%)
Query: 1626 EQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQIN 1685
E VYW+D AI+RA+++G+G +T+++ + + +AV+WV+R+L+WT T + I
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT--HTGTEHIE 59
Query: 1686 VARLDG-SFKNAVVQGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQ 1741
V L+ S K V + +++P + +HP G YW D G+N I AN+D +L +
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 1742 KG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800
G P GLA+D E KLYW + I ++D + + + ++ +L ++GD ++
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIY 177
Query: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNG 1855
W + K + V++ L+ V + + GTNP + NG
Sbjct: 178 WTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKV----VGTNPHADRNG 228
Score = 97.4 bits (241), Expect = 3e-19
Identities = 69/235 (29%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 2255 IFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
++++D I++ DGS T++ + + +A + +LYWT T I ++
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
T ++ D PRA L L +W +W E +P I RA L + L+
Sbjct: 65 STS------HKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVN 117
Query: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433
+ PNGLA+D + KLY+ DA DKIE D + R +LK + H F + G+ I+
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
Query: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGG 2488
WT W +++R +K V +N ++ +P MG+ AV N +P NGG
Sbjct: 178 WTAWQHHSIKRVHK-VKANRDVIIDQLPDL-MGLKAV-NVDKVVGTNPHADRNGG 229
Score = 89.4 bits (220), Expect = 8e-17
Identities = 48/182 (26%), Positives = 99/182 (54%), Gaps = 7/182 (3%)
Query: 275 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM 334
I+ ++ + +A++W+ + Y+ + I V N + L+ ++ P+ IAL P M
Sbjct: 29 INTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEM 88
Query: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
G ++ D+G+ P+++R ++D Q LV++ + +P+G+ LDL +YW DA D IE +
Sbjct: 89 GLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAI 148
Query: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
+ RQT+++ L H++ T+ +++Y T A Q S+ RV++ + ++
Sbjct: 149 SVDETKRQTLLKDKL-PHIFRFTLLGDFIYWT------AWQHHSIKRVHKVKANRDVIID 201
Query: 455 RV 456
++
Sbjct: 202 QL 203
Score = 50.8 bits (120), Expect = 3e-05
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 5/157 (3%)
Query: 1894 LYSVHEGIRGIPLDP-NDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS-TISRAKR 1951
LY H G I + N S ++ I H E YW+D G + I RA
Sbjct: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
Query: 1952 DQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPR 2011
D+ +V +G G+A+D G +YW D D IE ++ + R ++ L
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIF 167
Query: 2012 AITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048
T+ + +++WT W Q+ I+R R V+++
Sbjct: 168 RFTLLGD--FIYWTAW-QHHSIKRVHKVKANRDVIID 201
Score = 50.1 bits (118), Expect = 5e-05
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 556 ENLMNPRALDFHAETGFIYFAD-TTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614
E++ PRA+ H E G Y+ D + I R +D E ++ + G+A+D
Sbjct: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
Query: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
LYW G KT + + R+TL++ K+ H + L ++YWT W+
Sbjct: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
Score = 48.9 bits (115), Expect = 1e-04
Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 16/120 (13%)
Query: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
A+ +H + G YW +W P +R ++ L + L P G+
Sbjct: 81 AIALHPEMGLTYWIDWGEN--------PEIKRANLDRQELRV------LVNASLGWPNGL 126
Query: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
A+D G +YW D+ D IE + R+TL+ + PH L +YW+ W +H
Sbjct: 127 ALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQHH 184
Score = 38.5 bits (88), Expect = 0.15
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 8/116 (6%)
Query: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
G V++TD ++ + R +DG L+++KI P I ++ V+R +YW ++IEV
Sbjct: 3 GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 395 DYEGKGRQTII-------QGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN 443
+ ++ + I + GLT + ++ AN ++ + VN
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVN 117
Score = 38.1 bits (87), Expect = 0.20
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 561 PRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTD 620
P L + G +Y+ D + I +D T+R+T+LKD + ++ + +GD +YWT
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWT- 179
Query: 621 DGPKKTISVARLEKAAQTRKTLIE 644
+ S+ R+ K R +I+
Sbjct: 180 --AWQHHSIKRVHKVKANRDVIID 201
Score = 33.9 bits (76), Expect = 3.8
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548
G VYWTD + +A T++ P D+ V +R + G
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT-----GTEH 57
Query: 1549 CSHLCLINYNRTVSCAC----PHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604
CL + + + + P + LH + Y ++ + EI+ +LD
Sbjct: 58 IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY----WIDWGENPEIKRANLDRQELR 113
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
+++ ++ + + + D +E ++YW D +T I+ ++ T +T++ LP H
Sbjct: 114 VLVNASLGWPNGLAL---DLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP--HIFR 168
Query: 1665 VDWVSRNLFWTSY 1677
+ ++WT++
Sbjct: 169 FTLLGDFIYWTAW 181
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 176 bits (446), Expect = 5e-43
Identities = 92/242 (38%), Positives = 130/242 (53%), Gaps = 5/242 (2%)
Query: 3068 EQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIE 3127
E +YWTD IRR +L+GS Q L T +++PD +AV+WV +LYW G + IE
Sbjct: 2 EGHVYWTDDEVWA--IRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 3128 VSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK 3187
V+ LN +LVS + EPRA+ + + G YW DWG++ I R +D V+V+
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 3188 ITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWT 3247
+ WPNGL LD ++YW DA+ D IE S+D + R +L +PHIF TL D++YWT
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 3248 DWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLL 3307
W+ SI R HK N+ ++I L M L + V +P NGG +
Sbjct: 180 AWQHHSIKRVHKVK-ANRDVIIDQLPDLMGLKAVNV--DKVVGTNPHADRNGGAATCASS 236
Query: 3308 SP 3309
P
Sbjct: 237 RP 238
Score = 173 bits (438), Expect = 4e-42
Identities = 92/235 (39%), Positives = 136/235 (57%), Gaps = 15/235 (6%)
Query: 1936 IYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLN 1995
+YW D + I RA D + + ++ I + IAV+W+A ++YWT G + IEV LN
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 1996 GSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPN 2055
+ +++S+ +D+PRAI +HPE G +W +WG+ P I+R+ LD E VLVN S+ WPN
Sbjct: 65 STSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPN 124
Query: 2056 GISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTH 2115
G+++D Q+GKLYW DA+TDKIE I ++ R+ +L +F ++ DFIYW+ H
Sbjct: 125 GLALDLQEGKLYWGDAKTDKIEAISVDE-TKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 2116 ANGSIKR-----GSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGG 2165
SIKR ++D D +P L +K N D+ GTN A NGG
Sbjct: 184 --HSIKRVHKVKANRDVIIDQLP-------DLMGLKAVNVDKVVGTNPHADRNGG 229
Score = 124 bits (311), Expect = 2e-27
Identities = 75/252 (29%), Positives = 133/252 (52%), Gaps = 16/252 (6%)
Query: 571 GFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVA 630
G +Y+ D + I R +DG+ +T++ I++ + +AV+W+ +LYWT G + I V
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEH-IEVT 61
Query: 631 RLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRD 690
L + K L+ M PRAI + P G YW DW E+P+ ++RA +D
Sbjct: 62 CLNSTSH--KILVSEDMDEPRAIALHPEMGLTYWIDWGENPE------IKRANLDRQELR 113
Query: 691 IFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCH 750
+ V + ++ WPNGL+LD+ G+LYW DA D+IE I ++ T R+ + + +L H F
Sbjct: 114 VLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK-DKLPHIFRFTL 171
Query: 751 HGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN 810
G++++WT ++ S+ R+ + ++ + P + ++ + + VGTN
Sbjct: 172 LGDFIYWTAWQHHSIKRVHK----VKANRDVIIDQLPDLMGLKAVNV-DKVVGTNPHADR 226
Query: 811 NGGCSSLCLATP 822
NGG ++ + P
Sbjct: 227 NGGAATCASSRP 238
Score = 121 bits (304), Expect = 1e-26
Identities = 72/240 (30%), Positives = 122/240 (50%), Gaps = 10/240 (4%)
Query: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
+YWTD I R L +GA T +I + P+ +AV+W+A ++YW + + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQT----LINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1371 AKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRET 1430
L+ T L++ D++ PRAIAL P G+ +W DW + P I+ A++ R +
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGEN-PEIKRANLDRQELRVL--VN 117
Query: 1431 GSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGE 1490
S GWPNGL +D E ++ W DA++D I + D + +L+ + L H F TL G
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDF 175
Query: 1491 VYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCS 1550
+YWT W+ +++ + +K + ++ + L+ + + + NGG C+
Sbjct: 176 IYWTAWQHHSIKRVHKVKANRDVIIDQL-PDLMGLKAVNVDKVVGTNPHADRNGGAATCA 234
Score = 119 bits (298), Expect = 7e-26
Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 3912 GRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGN 3971
G VYWT+ I L + T N + + P IA++WVA +
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLIN---------------TKINDPDDIAVNWVARS 47
Query: 3972 VYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAM 4031
+YWT +G + IEV + + K L+S +DEP AI + P G YW DWG +P+I+ A +
Sbjct: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
Query: 4032 DGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSH 4091
D LV ++ WP GLA+D +LYW DAK I +I ++ T K L H
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDK--LPH 165
Query: 4092 PFSIDVFEDYIYGVTYINNRVFKIHK 4117
F + D+IY + ++ + ++HK
Sbjct: 166 IFRFTLLGDFIYWTAWQHHSIKRVHK 191
Score = 107 bits (267), Expect = 3e-22
Identities = 68/235 (28%), Positives = 119/235 (50%), Gaps = 13/235 (5%)
Query: 1626 EQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQIN 1685
E VYW+D AI+RA+++G+G +T+++ + + +AV+WV+R+L+WT T + I
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWT--HTGTEHIE 59
Query: 1686 VARLDG-SFKNAVVQGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSGQ 1741
V L+ S K V + +++P + +HP G YW D G+N I AN+D +L +
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 1742 KG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW 1800
G P GLA+D E KLYW + I ++D + + + ++ +L ++GD ++
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTL--LKDKLPHIFRFTLLGDFIY 177
Query: 1801 WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNG 1855
W + K + V++ L+ V + + GTNP + NG
Sbjct: 178 WTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKV----VGTNPHADRNG 228
Score = 97.4 bits (241), Expect = 3e-19
Identities = 69/235 (29%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 2255 IFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
++++D I++ DGS T++ + + +A + +LYWT T I ++
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
T ++ D PRA L L +W +W E +P I RA L + L+
Sbjct: 65 STS------HKILVSEDMDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVN 117
Query: 2374 KDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIF 2433
+ PNGLA+D + KLY+ DA DKIE D + R +LK + H F + G+ I+
Sbjct: 118 ASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
Query: 2434 WTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGG 2488
WT W +++R +K V +N ++ +P MG+ AV N +P NGG
Sbjct: 178 WTAWQHHSIKRVHK-VKANRDVIIDQLPDL-MGLKAV-NVDKVVGTNPHADRNGG 229
Score = 89.4 bits (220), Expect = 8e-17
Identities = 48/182 (26%), Positives = 99/182 (54%), Gaps = 7/182 (3%)
Query: 275 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM 334
I+ ++ + +A++W+ + Y+ + I V N + L+ ++ P+ IAL P M
Sbjct: 29 INTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEM 88
Query: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
G ++ D+G+ P+++R ++D Q LV++ + +P+G+ LDL +YW DA D IE +
Sbjct: 89 GLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAI 148
Query: 395 DYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVT 454
+ RQT+++ L H++ T+ +++Y T A Q S+ RV++ + ++
Sbjct: 149 SVDETKRQTLLKDKL-PHIFRFTLLGDFIYWT------AWQHHSIKRVHKVKANRDVIID 201
Query: 455 RV 456
++
Sbjct: 202 QL 203
Score = 50.8 bits (120), Expect = 3e-05
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 5/157 (3%)
Query: 1894 LYSVHEGIRGIPLDP-NDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS-TISRAKR 1951
LY H G I + N S ++ I H E YW+D G + I RA
Sbjct: 48 LYWTHTGTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANL 107
Query: 1952 DQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPR 2011
D+ +V +G G+A+D G +YW D D IE ++ + R ++ L
Sbjct: 108 DRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIF 167
Query: 2012 AITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN 2048
T+ + +++WT W Q+ I+R R V+++
Sbjct: 168 RFTLLGD--FIYWTAW-QHHSIKRVHKVKANRDVIID 201
Score = 50.1 bits (118), Expect = 5e-05
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 556 ENLMNPRALDFHAETGFIYFAD-TTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGD 614
E++ PRA+ H E G Y+ D + I R +D E ++ + G+A+D
Sbjct: 74 EDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEG 133
Query: 615 NLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWE 668
LYW G KT + + R+TL++ K+ H + L ++YWT W+
Sbjct: 134 KLYW---GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWTAWQ 182
Score = 48.9 bits (115), Expect = 1e-04
Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 16/120 (13%)
Query: 3904 AMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGI 3963
A+ +H + G YW +W P +R ++ L + L P G+
Sbjct: 81 AIALHPEMGLTYWIDWGEN--------PEIKRANLDRQELRV------LVNASLGWPNGL 126
Query: 3964 AIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNH 4023
A+D G +YW D+ D IE + R+TL+ + PH L +YW+ W +H
Sbjct: 127 ALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFTLLGDFIYWTAWQHH 184
Score = 38.5 bits (88), Expect = 0.15
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 8/116 (6%)
Query: 335 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVV 394
G V++TD ++ + R +DG L+++KI P I ++ V+R +YW ++IEV
Sbjct: 3 GHVYWTD-DEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 395 DYEGKGRQTII-------QGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN 443
+ ++ + I + GLT + ++ AN ++ + VN
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVN 117
Score = 38.1 bits (87), Expect = 0.20
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 561 PRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTD 620
P L + G +Y+ D + I +D T+R+T+LKD + ++ + +GD +YWT
Sbjct: 123 PNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTL--LGDFIYWT- 179
Query: 621 DGPKKTISVARLEKAAQTRKTLIE 644
+ S+ R+ K R +I+
Sbjct: 180 --AWQHHSIKRVHKVKANRDVIID 201
Score = 33.9 bits (76), Expect = 3.8
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 1489 GEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGP 1548
G VYWTD + +A T++ P D+ V +R + G
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHT-----GTEH 57
Query: 1549 CSHLCLINYNRTVSCAC----PHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYN 1604
CL + + + + P + LH + Y ++ + EI+ +LD
Sbjct: 58 IEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTY----WIDWGENPEIKRANLDRQELR 113
Query: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
+++ ++ + + + D +E ++YW D +T I+ ++ T +T++ LP H
Sbjct: 114 VLVNASLGWPNGLAL---DLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLP--HIFR 168
Query: 1665 VDWVSRNLFWTSY 1677
+ ++WT++
Sbjct: 169 FTLLGDFIYWTAW 181
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 156 bits (394), Expect = 5e-37
Identities = 175/645 (27%), Positives = 257/645 (39%), Gaps = 110/645 (17%)
Query: 2660 CERTSLCYAPSWVCDGANDC--GDYSDERDCPGVKRPRCPLNYFAC-PSGRCI--PMSWT 2714
C+ T+ C+ P D +C G D R+C V C + C P+ CI P S+
Sbjct: 770 CDTTARCH-PGTGVDYTCECASGYQGDGRNC--VDENECATGFHRCGPNSVCINLPGSYR 826
Query: 2715 CDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTC 2774
C+ E +D H CI + ++ C DGS A C
Sbjct: 827 CECRSGYEFADDR----------------HTCIL---ITPPANPCEDGSHTCAPAGQARC 867
Query: 2775 ---GPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDR--EFMCQNR- 2828
G S+FSC C+P + DG + C D DE C +TC + F C+ +
Sbjct: 868 VHHGGSTFSC----ACLPG-YAGDGHQ-CTD-VDECSENRCHPAATCYNTPGSFSCRCQP 920
Query: 2829 -------QCIPKHFV----CDHDRDCADGSDESPECEY--PTCG------PSEFRCANGR 2869
QCIP C+ + A P + P C P + + G
Sbjct: 921 GYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGF 980
Query: 2870 CLSSRQW--ECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQ 2927
C W + DG Q+ PHC +C R E LL +
Sbjct: 981 C-----WCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPT-ICERWR---ENLL---E 1028
Query: 2928 DDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECS 2987
G D++ C+DL +C K D C D D
Sbjct: 1029 HYGGTPRDDQYV--------------PQCDDLGHFIPLQCHG----KSDFCWCVDKDGRE 1070
Query: 2988 TTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEE--PFLIFANRYYLRKLNLD 3045
SQ C+ AP P VT FL++ + L L+
Sbjct: 1071 VQGTRSQPGTTP------ACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLN 1124
Query: 3046 GSNY------TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-GSNVQVLHR 3098
G+ TLL + V +D+D RE+M+YWTDV G I R L G+ + +
Sbjct: 1125 GTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA--GRTISRAGLELGAEPETIVN 1182
Query: 3099 TGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGY 3158
+GL +P+GLA+D + +YW D D IE + L+G+ R VL + L PRA+ VD G
Sbjct: 1183 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN 1242
Query: 3159 LYWTDWG-DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFAS 3217
LYWTDW + I +DG +R ++++T I PNGLT D ++ + WADA +E
Sbjct: 1243 LYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTL 1302
Query: 3218 LDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
DG+ R V+ ++ + F++ + D+ Y TDW + +K +G
Sbjct: 1303 PDGTGRRVI-QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 146 bits (368), Expect = 5e-34
Identities = 81/210 (38%), Positives = 115/210 (54%), Gaps = 8/210 (3%)
Query: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
+ +D+ + +YWTDV I R L + GA E ++ GL +PEGLA+D I +Y
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGL-ELGAEP--ETIVNSGLISPEGLAIDHIRRTMY 1201
Query: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
W +S LD+IE A LDG+ R L D+ +PRAIA+DP G L+WTDW+ P+IE +S+
Sbjct: 1202 WTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD 1261
Query: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
G RR + G PNGLT D K + W DA + + DG+G + L
Sbjct: 1262 GENRRILINT--DIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LK 1316
Query: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTG 1509
+PF++ Y Y TDWR + + NK +G
Sbjct: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 142 bits (358), Expect = 8e-33
Identities = 91/231 (39%), Positives = 127/231 (54%), Gaps = 11/231 (4%)
Query: 1889 VGSFLLYSVHEGIRGIPLD----PNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS 1944
VG+FLLY+ + I +PL+ D + L+ + G S+ VGID+ +YW D+
Sbjct: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTDVAGR 1164
Query: 1945 TISRAKRDQTWR-EDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVI 2003
TISRA + E +V +G+ EG+A+D I +YWTD D IE A L+GS R V+
Sbjct: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLF 1224
Query: 2004 SQGLDKPRAITVHPEKGYLFWTEWG-QYPRIERSRLDGTERVVLVNVSISWPNGISVDYQ 2062
L PRAI V P +G L+WT+W + P+IE S LDG R +L+N I PNG++ D
Sbjct: 1225 YTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPF 1284
Query: 2063 DGKLYWCDARTDKIERIDLETGENREVVLSSNNMDM-FSVSVFEDFIYWSD 2112
L W DA T K+E L G R V+ NN+ FS+ + D Y +D
Sbjct: 1285 SKLLCWADAGTKKLE-CTLPDGTGRRVI--QNNLKYPFSIVSYADHFYHTD 1332
Score = 121 bits (304), Expect = 1e-26
Identities = 77/217 (35%), Positives = 106/217 (48%), Gaps = 18/217 (8%)
Query: 3902 IDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPR 3961
I +D + VYWT+ TIS L A P T + SGL P
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPET--------------IVNSGLISPE 1189
Query: 3962 GIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG 4021
G+AID + +YWTDS D IE A + G RK L + P AI VDP+RG +YW+DW
Sbjct: 1190 GLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWN 1249
Query: 4022 NH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI 4080
PKIET+++DG R L+ +I P GL D ++ L WADA + +GT
Sbjct: 1250 REAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR 1309
Query: 4081 VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHK 4117
V + L +PFSI + D+ Y + + V ++K
Sbjct: 1310 VI---QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
Score = 108 bits (269), Expect = 2e-22
Identities = 65/211 (30%), Positives = 109/211 (51%), Gaps = 12/211 (5%)
Query: 564 LDFHAETGFIYFADTTSYLIGRQKID-GTERETILKDGIHNVEGVAVDWMGDNLYWTDDG 622
+D+ +Y+ D I R ++ G E ETI+ G+ + EG+A+D + +YWTD
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
Query: 623 PKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERA 682
K I A L+ RK L + +PRAI VDP+ G +YWTDW + ++E +
Sbjct: 1207 LDK-IESALLD--GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP-----KIETS 1258
Query: 683 WMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPEL 742
+DG +R I + + L PNGL+ D + L W DA ++E L +GT R+++ L
Sbjct: 1259 SLDGENRRILINTDIGL-PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN--NL 1315
Query: 743 NHAFGLCHHGNYLFWTEYRSGSVYRLERGVG 773
+ F + + ++ + T++R V + + G
Sbjct: 1316 KYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 102 bits (255), Expect = 7e-21
Identities = 69/205 (33%), Positives = 104/205 (50%), Gaps = 11/205 (5%)
Query: 1584 FLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTV--LDYDAREQRVYWSDVRTQAIKR 1641
FLLY + +I + L+ + T+ + + +DYD RE+ VYW+DV + I R
Sbjct: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
Query: 1642 AFIN-GTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAV-VQ 1699
A + G ET+V++ L + GLA+D + R ++WT D+ +I A LDGS + +
Sbjct: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT--DSVLDKIESALLDGSERKVLFYT 1226
Query: 1700 GLEQPHGLVVHPLRGKLYWTD----GDNISMANMDGSNRTLLFSGQKG-PVGLAIDFPES 1754
L P + V P+RG LYWTD I +++DG NR +L + G P GL D
Sbjct: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK 1286
Query: 1755 KLYWISSGNHTINRCNLDGSGLEVI 1779
L W +G + DG+G VI
Sbjct: 1287 LLCWADAGTKKLECTLPDGTGRRVI 1311
Score = 95.1 bits (235), Expect = 1e-18
Identities = 63/180 (35%), Positives = 93/180 (51%), Gaps = 8/180 (4%)
Query: 2272 GSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSG 2330
G+ TIV + + S EGLA T+YWT I +D + ER+ V+ +
Sbjct: 1174 GAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGS-----ERK-VLFYTD 1227
Query: 2331 DDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEK 2390
+PRA +D + ++WT+WN + P I ++L G N LI DI PNGL D ++
Sbjct: 1228 LVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKL 1287
Query: 2391 LYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVG 2450
L ++DA K+E DG+ R VI ++ +PF + Y +H + TDW R V NKH G
Sbjct: 1288 LCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 89.4 bits (220), Expect = 8e-17
Identities = 82/314 (26%), Positives = 138/314 (43%), Gaps = 32/314 (10%)
Query: 141 LQADGKT----CKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
LQ GK+ C D D V GT SQ T C+ + + P
Sbjct: 1052 LQCHGKSDFCWCVDKDGREVQGTRSQPGTTP------ACIPTVAPPMVRPTPRPDVTPPS 1105
Query: 197 RPPVLLIANSQNILATYLSGAQVS-----TITPTSTRQTTAMDFSYANETVCWVHVGDSA 251
LL Q I L+G ++ T+ +D+ V W D A
Sbjct: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWT---DVA 1162
Query: 252 AQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNG 311
+T + GL+ + TI ++ L E +AID + Y+ D + D+I +G
Sbjct: 1163 GRTISRA----GLELGAEPETI-VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDG 1217
Query: 312 DTCVTLLDLELYNPKGIALDPAMGKVFFTDYG-QIPKVERCDMDGQNRTKLVDSKIVFPH 370
L +L NP+ IA+DP G +++TD+ + PK+E +DG+NR L+++ I P+
Sbjct: 1218 SERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPN 1277
Query: 371 GITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDN 430
G+T D S+L+ WADA +E +G GR+ I +++ + + + ++ Y T+
Sbjct: 1278 GLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN--LKYPFSIVSYADHFYHTD--- 1332
Query: 431 ANAQQKTSVIRVNR 444
++ V+ VN+
Sbjct: 1333 ---WRRDGVVSVNK 1343
Score = 60.8 bits (146), Expect = 3e-08
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 22/153 (14%)
Query: 2886 DQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC-HINEC 2944
+ SD P NP C H C+ +++ C G V C G D R C NEC
Sbjct: 753 EDSDPTPGNP-CYDGSHMCDTTAR--CHPGTGVDYTCECAS----GYQGDGRNCVDENEC 805
Query: 2945 LSR-KLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADV--------DECSTTFPCSQ- 2994
+ G + C +L ++C CR G+ DD TC + D T P Q
Sbjct: 806 ATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
Query: 2995 RCINTHGS-YKCLCVEGYAPRGGDPHSCKAVTD 3026
RC++ GS + C C+ GYA GD H C V +
Sbjct: 866 RCVHHGGSTFSCACLPGYA---GDGHQCTDVDE 895
Score = 55.8 bits (133), Expect = 9e-07
Identities = 54/198 (27%), Positives = 69/198 (34%), Gaps = 37/198 (18%)
Query: 2830 CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSD 2889
C +CD C G+ CE CA+G R C EN+C
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTCE----------CASGYQGDGRN--CVDENECATGFH 810
Query: 2890 EAPKNPHCT----SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECL 2945
N C S +C + +F C+ L+ + C D S + C
Sbjct: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTCI---LITPPANPCEDGS-------HTCA 860
Query: 2946 SRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPC--SQRCINTHGSY 3003
+ C F C C PG+ DG C DVDECS C + C NT GS+
Sbjct: 861 PAGQARCVHHGGST---FSCACLPGYA--GDGHQCTDVDECSEN-RCHPAATCYNTPGSF 914
Query: 3004 KCLCVEGYAPRGGDPHSC 3021
C C GY GD C
Sbjct: 915 SCRCQPGYY---GDGFQC 929
Score = 52.0 bits (123), Expect = 1e-05
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 10/130 (7%)
Query: 540 GMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKD 599
G+++GA + I L++P L +Y+ D+ I +DG+ER+ +
Sbjct: 1170 GLELGA---EPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYT 1226
Query: 600 GIHNVEGVAVDWMGDNLYWTD---DGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
+ N +AVD + NLYWTD + PK I + L+ + R+ LI + P + D
Sbjct: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPK--IETSSLD--GENRRILINTDIGLPNGLTFD 1282
Query: 657 PLNGWMYWTD 666
P + + W D
Sbjct: 1283 PFSKLLCWAD 1292
Score = 50.8 bits (120), Expect = 3e-05
Identities = 98/399 (24%), Positives = 137/399 (34%), Gaps = 84/399 (21%)
Query: 3290 PNHPCKVNNGGCSNLCLLSPGGG--HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCI 3347
P +PC + C PG G + C C + + DGR CV ++C
Sbjct: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVD----------ENECA 806
Query: 3348 PFWWKCDTEDDCGDHSDEPPDCPEFKCRPG-QFQCSTGIC---TNPAFIC-DGDNDCQDN 3402
+ +C C P +CR G +F C T PA C DG + C
Sbjct: 807 TGFHRCGPNSVC----INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAP- 861
Query: 3403 SDEANCDIHVCLPSQFKCTNTNRCIPGI----FRCNGQDNCGDGEDERDCPEVTC--APN 3456
+ +A C H S F C C+PG +C D C + R P TC P
Sbjct: 862 AGQARCVHHG--GSTFSCA----CLPGYAGDGHQCTDVDEC---SENRCHPAATCYNTPG 912
Query: 3457 QFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDG 3516
F C RC P + C+ P + + +T C+ R A++
Sbjct: 913 SFSC----RCQPGYY--GDGFQCI-----PDSTSSLT------PCEQQQRHAQAQY---- 951
Query: 3517 EDDCGDGSDEPKEECDER-TCEPYQFRCKNNRCVPGRWQCDYD-NDCGDNSDEESCTPRP 3574
G+ +CDE+ P Q C W D D ++ TP
Sbjct: 952 ---AYPGARFHIPQCDEQGNFLPLQCHGSTGFC----WCVDPDGHEVPGTQTPPGSTPPH 1004
Query: 3575 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS-GHCIPLRWRCD 3633
C S I RW+ + + TPR D QC GH IPL +C
Sbjct: 1005 CGPSPEPTQRPPTICERWR-------ENLLEHYGGTPRDDQYVPQCDDLGHFIPL--QCH 1055
Query: 3634 ADAD---CMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL 3669
+D C+D E GT R+ P C T+ P+
Sbjct: 1056 GKSDFCWCVDKDGREVQGT--RSQPGTTPACIPTVAPPM 1092
Score = 48.9 bits (115), Expect = 1e-04
Identities = 34/122 (27%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 2022 LFWTEWGQYPRIERSRLD-GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERID 2080
++WT+ I R+ L+ G E +VN + P G+++D+ +YW D+ DKIE
Sbjct: 1156 VYWTDVAGRT-ISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESAL 1214
Query: 2081 LETGENREVVLSSN--NMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
L+ G R+V+ ++ N +V +YW+D I+ S D + + T I
Sbjct: 1215 LD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDI 1273
Query: 2139 GV 2140
G+
Sbjct: 1274 GL 1275
Score = 47.8 bits (112), Expect = 3e-04
Identities = 68/273 (24%), Positives = 91/273 (33%), Gaps = 49/273 (17%)
Query: 4188 PTPPPDAPRPGTCNLQCFNGGS-CFLNARRQP------KCRCQPRYTGD--KC-ELDQC- 4236
P P PG C++G C AR P C C Y GD C + ++C
Sbjct: 750 PVKEDSDPTPGN---PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECA 806
Query: 4237 --WEHCRNGGTCAASPSGMPTCRCPTGF------------TGPKCTQQVCAGYCA--NNS 4280
+ C C P G C C +G+ T P + + CA +
Sbjct: 807 TGFHRCGPNSVCINLP-GSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
Query: 4281 TCTVNQGNQPQCRCLPGFLGDRCQ---YRQCS-GYCENFGTCQMAADGSRQCRCTA--YF 4334
C + G+ C CLPG+ GD Q +CS C TC GS CRC Y
Sbjct: 866 RCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATC-YNTPGSFSCRCQPGYYG 924
Query: 4335 EGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRV-APSC--------LTCVGHCSNGG 4385
+G +C + S C ++ R P C L C G
Sbjct: 925 DGFQCIPDSTSSLT--PCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCW 982
Query: 4386 SCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQP 4418
+ +P Q PP T P C Q+P
Sbjct: 983 CVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRP 1015
Score = 45.4 bits (106), Expect = 0.001
Identities = 46/151 (30%), Positives = 61/151 (40%), Gaps = 23/151 (15%)
Query: 39 TC-ISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEH--NCLGTELCVPMS--RLCN 93
TC + G++ DG R+C D ++ A RC PN N G+ C S +
Sbjct: 785 TCECASGYQGDG-RNCVDENECATGF------HRCGPNSVCINLPGSYRCECRSGYEFAD 837
Query: 94 GVQDCMDGSDEGPHCRELQGNCSRLG---CQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
C+ + C + C+ G C HH T +C C + DG C D
Sbjct: 838 DRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTF---SCACLPGYA--GDGHQCTD 892
Query: 151 FDECSVYGTC--SQLCTNTDGSFICGCVEGY 179
DECS C + C NT GSF C C GY
Sbjct: 893 VDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
Score = 44.3 bits (103), Expect = 0.003
Identities = 22/60 (36%), Positives = 31/60 (51%), Gaps = 5/60 (8%)
Query: 132 TCYCNSSFQLQADGKTCKDFDECSV-YGTC--SQLCTNTDGSFICGCVEGYLLQPDNRSC 188
TC C S +Q DG+ C D +EC+ + C + +C N GS+ C C GY D +C
Sbjct: 785 TCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
Score = 40.8 bits (94), Expect = 0.031
Identities = 52/215 (24%), Positives = 73/215 (33%), Gaps = 43/215 (20%)
Query: 3443 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDG-SDEPANCT-QMTCGVDEFR 3500
ED P C C T RC P V D +C G + NC + C R
Sbjct: 753 EDSDPTPGNPCYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENECATGFHR 811
Query: 3501 CKDSGRCI--PARWKCDGEDDCGDGSDE--------PKEECDE--RTCEPY-QFRCKNN- 3546
C + CI P ++C+ D P C++ TC P Q RC ++
Sbjct: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
Query: 3547 ------RCVPGRWQCDYDNDCGDNSDEESCTPRPC--------SESEFSCANGRCIAGRW 3592
C+PG Y D +D + C+ C + FSC RC G +
Sbjct: 872 GSTFSCACLPG-----YAGDGHQCTDVDECSENRCHPAATCYNTPGSFSC---RCQPGYY 923
Query: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIP 3627
GD TP C+ Q ++ + P
Sbjct: 924 ---GDGFQCIPDSTSSLTP-CEQQQRHAQAQYAYP 954
Score = 38.9 bits (89), Expect = 0.12
Identities = 47/214 (21%), Positives = 72/214 (33%), Gaps = 53/214 (24%)
Query: 1058 PPGGCHTDEFQCRLDGLCIP---LRWRCDGDT----DCMDSSDEKSCEGVTHVCDP-SVK 1109
P C+ C C P + + C+ + D + DE C H C P SV
Sbjct: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVC 818
Query: 1110 FGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGN 1169
S RC ++ E D C + PP++PC + + C P G
Sbjct: 819 INLPGSYRCECRSGY-------EFADDRHTC--ILITPPANPCEDGSHTCAPA-----GQ 864
Query: 1170 DDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAK 1229
C +++GG + +C+ PG D H C C++
Sbjct: 865 ARC--------------VHHGGSTFSCACLPG------------YAGDGHQCTDVDECSE 898
Query: 1230 HLKC--SQKCDQNKFSVKCSCYEGWVLEPDGESC 1261
+ +C + C S C C G+ DG C
Sbjct: 899 N-RCHPAATCYNTPGSFSCRCQPGYY--GDGFQC 929
Score = 37.0 bits (84), Expect = 0.45
Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 26/119 (21%)
Query: 802 VGTNKCRVNNGGC--SSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPP--QCQPG 857
V N+C C +S+C+ PGS +C C D TC+ + PP C+ G
Sbjct: 800 VDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI----LITPPANPCEDG 855
Query: 858 EFACA---NSRCIQ---ERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRFKCENNRCIP 909
CA +RC+ + C CL P H C +D +C NRC P
Sbjct: 856 SHTCAPAGQARCVHHGGSTFSC----ACL------PGYAGDGHQC-TDVDECSENRCHP 903
Score = 34.7 bits (78), Expect = 2.2
Identities = 35/139 (25%), Positives = 53/139 (38%), Gaps = 24/139 (17%)
Query: 1148 PSHPCANNTSVC-----LPPDKLCDGNDDCGDG-SDEGELC---DQCSLNNGGCSHN--C 1196
P +PC + + +C P D +C G +G C ++C+ C N C
Sbjct: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVC 818
Query: 1197 SVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK-----CS----QKCDQNKFSV-KC 1246
PG C C G E D HTC + + A + C+ +C + S C
Sbjct: 819 INLPGS-YRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSC 877
Query: 1247 SCYEGWVLEPDGESCRSLD 1265
+C G+ DG C +D
Sbjct: 878 ACLPGYA--GDGHQCTDVD 894
Score = 33.9 bits (76), Expect = 3.8
Identities = 39/166 (23%), Positives = 58/166 (34%), Gaps = 37/166 (22%)
Query: 3725 GTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDG--SDEEDCSIDPKL 3782
G +ED +P + C D RC + + +C G D +C +
Sbjct: 749 GPVKEDSDPTPGNP--CYDGSHMCDTTARCHPGT-GVDYTCECASGYQGDGRNCVDE--- 802
Query: 3783 TSCATNASICGDEARCVRTEKAAYCACRSGFH-----------TVPGQPGCQDIN----- 3826
CAT CG + C+ + C CRSG+ T P P C+D +
Sbjct: 803 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP-CEDGSHTCAP 861
Query: 3827 ----ECLRFG----TCSQLCNNTKGGHLCS----CARNFMKTHNTC 3860
C+ G +C+ L GH C+ C+ N TC
Sbjct: 862 AGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATC 907
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 138 bits (347), Expect = 1e-31
Identities = 69/161 (42%), Positives = 89/161 (55%), Gaps = 13/161 (8%)
Query: 3498 EFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDY 3557
+F C+ +GRCI +CDG DC D SDE CD +QF CKN C P W CD
Sbjct: 456 QFTCR-TGRCIRKELRCDGWADCTDHSDELNCSCDAG----HQFTCKNKFCKPLFWVCDS 510
Query: 3558 DNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC----TPRC 3613
NDCGDNSDE+ C+ C F C+NG+C++ +C+G DC DGSDE C C
Sbjct: 511 VNDCGDNSDEQGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 3614 DMDQFQCKSGHCIPL-RWRCDADADCMDGSDEEACGTGVRT 3653
++C +G C+ CD DC DGSDE+ C G+R+
Sbjct: 568 TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608
Score = 137 bits (346), Expect = 2e-31
Identities = 77/178 (43%), Positives = 94/178 (52%), Gaps = 17/178 (9%)
Query: 3617 QFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGE 3676
QF C++G CI RCD ADC D SDE C +F C N CKPL W CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG----HQFTCKNKFCKPLFWVCDSV 511
Query: 3677 DDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTA 3736
+DCGDNSDE C P + FRC N + CL +QC+G D+CGDG+DE C P
Sbjct: 512 NDCGDNSDEQGCSC------PAQTFRCSNGK-CLSKSQQCNGKDDCGDGSDEASC--PKV 562
Query: 3737 HTTHCKDKKEFLCRNQRCLS-SSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICG 3793
+ C K + C N CLS + C+ +DC DGSDE+DC D L S A + G
Sbjct: 563 NVVTC-TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC--DCGLRSFTRQARVVG 617
Score = 135 bits (340), Expect = 9e-31
Identities = 72/162 (44%), Positives = 92/162 (56%), Gaps = 13/162 (8%)
Query: 938 PNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCD 997
P QF+C +GRCI CD DC D SDE +C+ C QFTC N C + W CD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDE-LNCS---CDAGHQFTCKNKFCKPLFWVCD 509
Query: 998 NDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATR 1057
+ NDCGDNSDE GC SC + F+C++G+C+ + C+G +DCGD SDE N T
Sbjct: 510 SVNDCGDNSDEQGC--SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVT- 566
Query: 1058 PPGGCHTDEFQCRLDGLCIPL-RWRCDGDTDCMDSSDEKSCE 1098
C ++C L+GLC+ CDG DC D SDEK C+
Sbjct: 567 ----CTKHTYRC-LNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 131 bits (329), Expect = 2e-29
Identities = 75/193 (38%), Positives = 93/193 (48%), Gaps = 35/193 (18%)
Query: 2593 DGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGV 2652
D SD P G+F CR G CI RC+ + DC D SDE+NCS D F
Sbjct: 448 DSSDPCP--------GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSC-DAGHQFTC-- 496
Query: 2653 KGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMS 2712
+ C WVCD NDCGD SDE+ C CP F C +G+C+ S
Sbjct: 497 ---------KNKFCKPLFWVCDSVNDCGDNSDEQGC------SCPAQTFRCSNGKCLSKS 541
Query: 2713 WTCDKEDDCEHGEDETHCNKF----CSEAQFECQNHRCISK-QWLCDGSDDCGDGSDEAA 2767
C+ +DDC G DE C K C++ + C N C+SK CDG +DC DGSDE
Sbjct: 542 QQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE-K 600
Query: 2768 HCEGKTCGPSSFS 2780
C+ CG SF+
Sbjct: 601 DCD---CGLRSFT 610
Score = 130 bits (328), Expect = 2e-29
Identities = 70/168 (41%), Positives = 90/168 (53%), Gaps = 14/168 (8%)
Query: 847 SYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNR 906
SY C PG+F C RCI++ +CDG DC D+SDE C +F C+N
Sbjct: 446 SYDSSDPC-PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA----GHQFTCKNKF 500
Query: 907 CIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSD 966
C P W+CD NDCG++ DE +C A+T F C++G+C+ S C+ DDCGD SD
Sbjct: 501 CKPLFWVCDSVNDCGDNSDEQGCSCPAQT-----FRCSNGKCLSKSQQCNGKDDCGDGSD 555
Query: 967 ESASCAYPTCFPLTQFT--CNNGRCINI-NWRCDNDNDCGDNSDEAGC 1011
E ASC T+ T C NG C++ N CD DC D SDE C
Sbjct: 556 E-ASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 119 bits (297), Expect = 9e-26
Identities = 61/156 (39%), Positives = 84/156 (53%), Gaps = 8/156 (5%)
Query: 3538 PYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSES-EFSCANGRCIAGRWKCDG 3596
P QF C+ RC+ +CD DC D+SDE +C+ C +F+C N C W CD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTCKNKFCKPLFWVCDS 510
Query: 3597 DHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC-GTGVRTCP 3655
+DC D SDE+ C+ C F+C +G C+ +C+ DC DGSDE +C V TC
Sbjct: 511 VNDCGDNSDEQGCS--CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 3656 LDEFQCNNTLCKPLA-WKCDGEDDCGDNSDENPEEC 3690
++C N LC +CDG++DC D SDE +C
Sbjct: 569 KHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 119 bits (297), Expect = 9e-26
Identities = 66/156 (42%), Positives = 82/156 (52%), Gaps = 15/156 (9%)
Query: 2738 QFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPS-SFSCPGTHVCVPERWLCDG 2796
QF C+ RCI K+ CDG DC D SDE +C +C F+C C P W+CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDEL-NC---SCDAGHQFTCKNKF-CKPLFWVCDS 510
Query: 2797 DKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDES--PECE 2854
DC D +DE GC +C + F C N +C+ K C+ DC DGSDE+ P+
Sbjct: 511 VNDCGDNSDEQ---GC----SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563
Query: 2855 YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
TC +RC NG CLS ECDG+ DC D SDE
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 114 bits (285), Expect = 2e-24
Identities = 66/167 (39%), Positives = 87/167 (52%), Gaps = 18/167 (10%)
Query: 3338 QFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPG-QFQCSTGICTNPAFICDGD 3396
QF C+ +CI +CD DC DHSDE +C C G QF C C ++CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDE-LNC---SCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 3397 NDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPE---VTC 3453
NDC DNSDE C C F+C+N +C+ +CNG+D+CGDG DE CP+ VTC
Sbjct: 512 NDCGDNSDEQGCS---CPAQTFRCSN-GKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 3454 APNQFQCSITKRCIPR-VWVCDRDNDCVDGSDEPANCTQMTCGVDEF 3499
+ ++C + C+ + CD DC DGSDE CG+ F
Sbjct: 568 TKHTYRC-LNGLCLSKGNPECDGKEDCSDGSDE----KDCDCGLRSF 609
Score = 113 bits (283), Expect = 4e-24
Identities = 65/164 (39%), Positives = 89/164 (54%), Gaps = 13/164 (7%)
Query: 3376 PGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNG 3435
PGQF C TG C CDG DC D+SDE NC QF C N C P + C+
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA--GHQFTCKN-KFCKPLFWVCDS 510
Query: 3436 QDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ---M 3492
++CGD DE+ C +C F+CS +C+ + C+ +DC DGSDE A+C + +
Sbjct: 511 VNDCGDNSDEQGC---SCPAQTFRCS-NGKCLSKSQQCNGKDDCGDGSDE-ASCPKVNVV 565
Query: 3493 TCGVDEFRCKDSGRCI-PARWKCDGEDDCGDGSDEPKEECDERT 3535
TC +RC +G C+ +CDG++DC DGSDE +C R+
Sbjct: 566 TCTKHTYRCL-NGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608
Score = 113 bits (283), Expect = 4e-24
Identities = 67/175 (38%), Positives = 93/175 (53%), Gaps = 26/175 (14%)
Query: 1019 QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPL 1078
QF C +GRCI + CDG DC D+SDE + +C +F C+ + C PL
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG----------HQFTCK-NKFCKPL 504
Query: 1079 RWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEE 1138
W CD DC D+SDE+ C C P+ F C + +C+SK+ C+G +DC D SDE
Sbjct: 505 FWVCDSVNDCGDNSDEQGCS-----C-PAQTFRCSNG-KCLSKSQQCNGKDDCGDGSDEA 557
Query: 1139 NCES---LACRPPSHPCANNTSVCLPP-DKLCDGNDDCGDGSDEGELCDQCSLNN 1189
+C + C ++ C N +CL + CDG +DC DGSDE + CD C L +
Sbjct: 558 SCPKVNVVTCTKHTYRCLN--GLCLSKGNPECDGKEDCSDGSDEKD-CD-CGLRS 608
Score = 108 bits (271), Expect = 9e-23
Identities = 57/148 (38%), Positives = 73/148 (49%), Gaps = 11/148 (7%)
Query: 2662 RTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY-FACPSGRCIPMSWTCDKEDD 2720
RT C CDG DC D+SDE +C C + F C + C P+ W CD +D
Sbjct: 460 RTGRCIRKELRCDGWADCTDHSDELNCS------CDAGHQFTCKNKFCKPLFWVCDSVND 513
Query: 2721 CEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAA--HCEGKTCGPSS 2778
C DE C+ C F C N +C+SK C+G DDCGDGSDEA+ TC +
Sbjct: 514 CGDNSDEQGCS--CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHT 571
Query: 2779 FSCPGTHVCVPERWLCDGDKDCADGADE 2806
+ C CDG +DC+DG+DE
Sbjct: 572 YRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 107 bits (267), Expect = 3e-22
Identities = 61/155 (39%), Positives = 78/155 (50%), Gaps = 22/155 (14%)
Query: 2504 SCRGGRILQDDLTCRA----------VNSSCRAQDEFECANGECINFSLTCDGVPHCKDK 2553
+CR GR ++ +L C +N SC A +F C N C CD V C D
Sbjct: 458 TCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDN 517
Query: 2554 SDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC---NKTACGVGEF 2610
SDE+ C ++ TFR CSNG+C+S CNG DDCGDGSDE C N C +
Sbjct: 518 SDEQGCSCPAQ----TFR-CSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTY 572
Query: 2611 RCRDGTCIGNSS-RCNQFVDCEDASDEMNCSATDC 2644
RC +G C+ + C+ DC D SDE +C DC
Sbjct: 573 RCLNGLCLSKGNPECDGKEDCSDGSDEKDC---DC 604
Score = 101 bits (252), Expect = 1e-20
Identities = 52/128 (40%), Positives = 72/128 (56%), Gaps = 10/128 (7%)
Query: 3325 SDGRTCVSNCTAS-QFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST 3383
SD C +C A QF CKN C P +W CD+ +DCGD+SDE C C F+CS
Sbjct: 481 SDELNC--SCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE-QGC---SCPAQTFRCSN 534
Query: 3384 GICTNPAFICDGDNDCQDNSDEANC---DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCG 3440
G C + + C+G +DC D SDEA+C ++ C ++C N G C+G+++C
Sbjct: 535 GKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCS 594
Query: 3441 DGEDERDC 3448
DG DE+DC
Sbjct: 595 DGSDEKDC 602
Score = 87.0 bits (214), Expect = 4e-16
Identities = 58/164 (35%), Positives = 75/164 (45%), Gaps = 33/164 (20%)
Query: 2822 EFMCQNRQCIPKHFVCDHDRDCADGSDE-SPECEYPTCGPSEFRCANGRCLSSRQWECDG 2880
+F C+ +CI K CD DC D SDE + C+ +F C N C W CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCSCD----AGHQFTCKNKFC-KPLFWVCDS 510
Query: 2881 ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC- 2939
NDC D SDE Q C A + F CS+G+C++++ CNG+DDCGD SDE C
Sbjct: 511 VNDCGDNSDE---------QGCSCPAQT-FRCSNGKCLSKSQQCNGKDDCGDGSDEASCP 560
Query: 2940 HINE--------------CLSRKLSGC--SQDCEDLKIGFKCRC 2967
+N CLS+ C +DC D C C
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 61.2 bits (147), Expect = 2e-08
Identities = 28/84 (33%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 854 CQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPA-LCHQHTCPSDRFKCENNRCIPN-R 911
C F C+N +C+ + +C+G +DC D SDEA + TC ++C N C+
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 912 WLCDGDNDCGNSEDESNATCSART 935
CDG DC + DE + C R+
Sbjct: 585 PECDGKEDCSDGSDEKDCDCGLRS 608
Score = 60.5 bits (145), Expect = 4e-08
Identities = 30/79 (37%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
+C + F C + C+SK +C+G+ DC DGSDEA CP+ C + + CL
Sbjct: 524 SCPAQTFRCSNG-KCLSKSQQCNGKDDCGDGSDEAS--CPKVNVVTCTKHTYRCLNGLCL 580
Query: 86 VPMSRLCNGVQDCMDGSDE 104
+ C+G +DC DGSDE
Sbjct: 581 SKGNPECDGKEDCSDGSDE 599
Score = 58.9 bits (141), Expect = 1e-07
Identities = 52/176 (29%), Positives = 65/176 (36%), Gaps = 29/176 (16%)
Query: 22 DAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLG 81
D+ C P QF CR CI K RCDG DC D SDE C C+
Sbjct: 448 DSSDPC-PGQFTCRTG-RCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCK-------- 497
Query: 82 TELCVPMSRLCNGVQDCMDGSDE-GPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
+ C P+ +C+ V DC D SDE G C CS C S
Sbjct: 498 NKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKC----------------LSKS 541
Query: 141 LQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
Q +GK D + S +C ++ T C+ G L N C K + D
Sbjct: 542 QQCNGK--DDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSD 595
Score = 41.6 bits (96), Expect = 0.018
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 7/90 (7%)
Query: 2476 SCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANG 2535
SC R +NG C + Q + C G D+ +C VN + + C NG
Sbjct: 524 SCPAQTFRCSNGKCLSK---SQQCNGKDDCGDG---SDEASCPKVNVVTCTKHTYRCLNG 577
Query: 2536 ECINF-SLTCDGVPHCKDKSDEKPSYCNSR 2564
C++ + CDG C D SDEK C R
Sbjct: 578 LCLSKGNPECDGKEDCSDGSDEKDCDCGLR 607
Score = 34.3 bits (77), Expect = 2.9
Identities = 43/160 (26%), Positives = 62/160 (38%), Gaps = 45/160 (28%)
Query: 4258 CPTGFT--GPKCTQQV--CAGY--CANNS---TCTVNQGNQPQCR---CLPGFLGDRCQY 4305
CP FT +C ++ C G+ C ++S C+ + G+Q C+ C P F
Sbjct: 453 CPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFW------ 506
Query: 4306 RQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNC 4365
C++ C +D + C C A + RC G C+ Q + +C
Sbjct: 507 -----VCDSVNDCGDNSD-EQGCSCPA----------QTFRCSNGKCLSKSQQCNGKDDC 550
Query: 4366 TDGRVAPSC-----LTCVGH---CSNGGSCTMNSKMMPEC 4397
DG SC +TC H C NG SK PEC
Sbjct: 551 GDGSDEASCPKVNVVTCTKHTYRCLNG---LCLSKGNPEC 587
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 134 bits (338), Expect = 2e-30
Identities = 87/246 (35%), Positives = 118/246 (47%), Gaps = 46/246 (18%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCEL-DQCW--EHCRNGGTCAA---SPSGMPT-- 4255
C NGG+C + Q C+C P + G+ C+ D C + C+NGG+C A +P G+P+
Sbjct: 35 CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94
Query: 4256 --------CRCPTGFTGPKCTQQV---CA-GYCANNSTCTVNQGNQPQCRCLPGFLGDRC 4303
C C GFTG +C ++ C +C+ C + +PQC C+PG+ G++C
Sbjct: 95 SPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC 154
Query: 4304 QYRQ-CSGY-CENFGTCQMAADGSRQCRCTAYFEGSRCE--VNKCSR----CLEGACVVN 4355
Q R CS C N G C +A QC C FEG CE VN+C + C +G N
Sbjct: 155 QLRDFCSANPCVNGGVC-LATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHN 213
Query: 4356 KQSGDVTCNCTDGRVAPSCLTCVG-----HCSNGGSCTMNSKMMPE-------CQCPPHM 4403
G C C G+ P C G CSNGG+C ++MPE C CPP
Sbjct: 214 -TLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTC----QLMPEKDSTFHLCLCPPGF 268
Query: 4404 TGPRCE 4409
GP CE
Sbjct: 269 IGPDCE 274
Score = 119 bits (298), Expect = 7e-26
Identities = 101/308 (32%), Positives = 121/308 (39%), Gaps = 61/308 (19%)
Query: 4160 CLLSPSGPVCTCPNGKR----------------LDNGTCVPVPSP---TPPPDAPRPGT- 4199
C PSG CTCP G L+ G+C P P T PP P
Sbjct: 706 CYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 765
Query: 4200 ------CNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCE---LDQCWEH-CRNGGTCAAS 4249
+ CFNGG+C +N C C + G +CE C + CRN TC S
Sbjct: 766 TSTDYCVSAPCFNGGTC-VNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDS 824
Query: 4250 PSGMPTCRCPTGFTGPKC--TQQVCAGY-CANNSTCTVNQGNQPQCRCLPGFLGDRC--- 4303
P G P C CPTG+TG C +CA C NS C + G C CL G+ G C
Sbjct: 825 PQG-PRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHC-LQTGPSFHCLCLQGWTGPLCNLP 882
Query: 4304 ----------QYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCE--VNKCSR--CLE 4349
Q S C N G C + + S C C F+GS C+ VN C C
Sbjct: 883 LSSCQKAALSQGIDVSSLCHNGGLC-VDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQN 941
Query: 4350 GACVVNKQSGDVTCNCTDGRVAPSCL----TCVGH-CSNGGSCTMNSKMMPECQCPPHMT 4404
GA + + SG C C G +C C C N G+CT C CPP
Sbjct: 942 GATCMAQPSG-YLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGF-HCACPPGFV 999
Query: 4405 GPRCEEHV 4412
G RCE V
Sbjct: 1000 GLRCEGDV 1007
Score = 113 bits (283), Expect = 4e-24
Identities = 88/282 (31%), Positives = 114/282 (40%), Gaps = 41/282 (14%)
Query: 4163 SPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQP---K 4219
+P CTC +G + V P +A G + C +GG+C+ QP
Sbjct: 659 APPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCY----PQPSGYN 714
Query: 4220 CRCQPRYTGDKC--ELDQCWE-HCRNGGTCAASPSGMPTCRCPTGFTGPKC---TQQVCA 4273
C C YTG C E+ C C NGG+C SP G C CP TGP+C T +
Sbjct: 715 CTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGY-YCTCPPSHTGPQCQTSTDYCVS 773
Query: 4274 GYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYR---QCS-GYCENFGTCQMAADGSRQCR 4329
C N TC VN+ C C GF G RC+ + C+ C N TCQ + G R C
Sbjct: 774 APCFNGGTC-VNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPR-CL 831
Query: 4330 CTAYFEGSRCEVNKCSRCLEGACVVNK---QSG-DVTCNCTDGRVAPSC----------- 4374
C + G C+ C + C N Q+G C C G P C
Sbjct: 832 CPTGYTGGSCQ-TLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAA 890
Query: 4375 ----LTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
+ C NGG C ++S C CPP G C++HV
Sbjct: 891 LSQGIDVSSLCHNGGLC-VDSGPSYFCHCPPGFQGSLCQDHV 931
Score = 107 bits (267), Expect = 3e-22
Identities = 89/290 (30%), Positives = 114/290 (39%), Gaps = 44/290 (15%)
Query: 4169 CTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTG 4228
C CP G+ + C P PP GTC L + L C C P + G
Sbjct: 220 CLCPVGQ--EGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHL-------CLCPPGFIG 270
Query: 4229 DKCEL--DQCWEH-CRNGGTCAASPSGMPTCRCPTGFTGPKCTQQV--CAG----YCANN 4279
CE+ D C H C+NGGTC TC CP +TG C++ V C +C N
Sbjct: 271 PDCEVNPDNCVSHQCQNGGTCQDGLDTY-TCLCPETWTGWDCSEDVDECETQGPPHCRNG 329
Query: 4280 STCTVNQGNQPQCRCLPGFLGDRCQYR--QC-SGYCENFGTCQMAADGSRQCRCTAYFEG 4336
TC N C C+ G+ G C+ C + C TC + GS C C G
Sbjct: 330 GTCQ-NSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTC-IDRVGSFSCLCPPGRTG 387
Query: 4337 SRCEVNKCSRCL------EGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHC--------- 4381
C + CL + C N +G C C G P+C + C
Sbjct: 388 LLCHLE--DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSP 445
Query: 4382 -SNGGSCTMNSKMMPECQCPPHMTGPRCE-EHVFSQQQPGHIASILIPLL 4429
+GGSC +N+ C CPP TG RCE +H QP H S + LL
Sbjct: 446 CEHGGSC-LNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLL 494
Score = 101 bits (251), Expect = 2e-20
Identities = 105/336 (31%), Positives = 131/336 (38%), Gaps = 85/336 (25%)
Query: 4127 TGGLSHASDVVLYHQ-HKQPEV-TNPCDRKKCEWLCLLSP--SGPVCTCPNGKRLDNGTC 4182
TG L H D+ L H + TNP LCL P SGP C D C
Sbjct: 386 TGLLCHLEDMCLSQPCHGDAQCSTNPLTGST---LCLCQPGYSGPTC------HQDLDEC 436
Query: 4183 VPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELD--QCW-EH 4239
+ P C +GGSC LN C C P YTG +CE D +C +
Sbjct: 437 LMAQQGPSP------------CEHGGSC-LNTPGSFNCLCPPGYTGSRCEADHNECLSQP 483
Query: 4240 CRNGGTCAASPSGMPTCRCPTGFTGPKC---TQQVCAGYCANNSTCTVNQGNQPQCRCLP 4296
C G TC + C CP G G C T + + C N++ C + N QC CLP
Sbjct: 484 CHPGSTCLDLLATF-HCLCPPGLEGQLCEVETNECASAPCLNHADCH-DLLNGFQCICLP 541
Query: 4297 GFLGDRCQ--YRQC-SGYCENFGTCQMAADGSRQCRCTAYFEGSRC--EVNKC------- 4344
GF G RC+ +C S C N G CQ G+ C+C FEG RC EV++C
Sbjct: 542 GFSGTRCEEDIDECRSSPCANGGQCQ-DQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPV 600
Query: 4345 -SRCLE--GA------------------CVVN---------KQSGDVTCNCTDGRVAPSC 4374
+ CL+ GA C N Q C C DG +P C
Sbjct: 601 GASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDG--SPGC 658
Query: 4375 LTCVGHCS-NGGSCTMNSKMMPECQCPPHMTGPRCE 4409
+C+ + G C +S C C TGP CE
Sbjct: 659 APPEDNCTCHHGHCQRSS-----CVCDVGWTGPECE 689
Score = 98.2 bits (243), Expect = 2e-19
Identities = 90/284 (31%), Positives = 108/284 (38%), Gaps = 49/284 (17%)
Query: 4159 LCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQP 4218
LC+ S C CP G C +P RP C NG +C QP
Sbjct: 906 LCVDSGPSYFCHCPPG--FQGSLCQDHVNPCES----RP------CQNGATCMA----QP 949
Query: 4219 K---CRCQPRYTGDKC--ELDQCWEH-CRNGGTCAASPSGMPTCRCPTGFTGPKCTQQV- 4271
C+C P Y G C ELD C C N GTC P G C CP GF G +C V
Sbjct: 950 SGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFH-CACPPGFVGLRCEGDVD 1008
Query: 4272 -CAGY-CANNSTCTVNQ-GNQPQCRCLPGFLGDRCQYR--QC-SGYCENFGTCQMAADGS 4325
C C T + N C+CLPG G C+ C S C + GTC+ A
Sbjct: 1009 ECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSP 1068
Query: 4326 RQ--CRCTAYFEGSRCEVNKCS----RCLEGA-CVVNKQSG-DVTCNCTDGRVAPSCLT- 4376
C C FEG C S C G C+ + + G C C G P CLT
Sbjct: 1069 LGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP 1128
Query: 4377 -----C--VGHCSNGGSCTMNSKMMP---ECQCPPHMTGPRCEE 4410
C C GSC+ + + C CP GPRC++
Sbjct: 1129 PAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQK 1172
Score = 96.3 bits (238), Expect = 6e-19
Identities = 88/307 (28%), Positives = 118/307 (38%), Gaps = 49/307 (15%)
Query: 4144 QPEVTNPCDRKKCE--WLCLLSPSG-PVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC 4200
Q ++ +PC C C + SG P C+C G + S P
Sbjct: 115 QAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANP---------- 164
Query: 4201 NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELD--QCWEH---CRNGGTCAASPSGMPT 4255
C NGG C L Q +C C P + G CE D +C++ C G +C + G
Sbjct: 165 ---CVNGGVC-LATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSC-HNTLGSFQ 219
Query: 4256 CRCPTGFTGPKCTQQVCAG-----YCANNSTCTV---NQGNQPQCRCLPGFLGDRCQYRQ 4307
C CP G GP+C ++ AG C+N TC + C C PGF+G C+
Sbjct: 220 CLCPVGQEGPRC--ELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNP 277
Query: 4308 ---CSGYCENFGTCQMAADGSRQCRCTAYFEGSRC--EVNKCS-----RCLEGACVVNKQ 4357
S C+N GTCQ D + C C + G C +V++C C G N
Sbjct: 278 DNCVSHQCQNGGTCQDGLD-TYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQN-S 335
Query: 4358 SGDVTCNCTDGRVAPSCL----TCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVF 4413
+G C C G SC C+ GS ++ C CPP TG C
Sbjct: 336 AGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM 395
Query: 4414 SQQQPGH 4420
QP H
Sbjct: 396 CLSQPCH 402
Score = 94.7 bits (234), Expect = 2e-18
Identities = 70/221 (31%), Positives = 94/221 (42%), Gaps = 30/221 (13%)
Query: 4204 CFNGGSCFLNARRQP---KCRCQPRYTGDKC--ELDQCW-EHCRNGGTCAASPSGMPTCR 4257
C NGG C + QP C+C P + G +C E+D+C + C G +C P G C
Sbjct: 560 CANGGQC----QDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLP-GAFFCL 614
Query: 4258 CPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGT 4317
CP+GFTG C +CA +Q ++ C C G G C + + C + G
Sbjct: 615 CPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG--CAPPEDNCTCHH-GH 671
Query: 4318 CQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGAC----VVNKQSGDVTCNCTDGRVAPS 4373
CQ ++ C C + G CE + C+ C Q C C G P+
Sbjct: 672 CQRSS-----CVCDVGWTGPECEA-ELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPT 725
Query: 4374 C----LTC-VGHCSNGGSCTMNSKMMPECQCPPHMTGPRCE 4409
C C G C NGGSC S C CPP TGP+C+
Sbjct: 726 CSEEMTACHSGPCLNGGSCN-PSPGGYYCTCPPSHTGPQCQ 765
Score = 94.4 bits (233), Expect = 2e-18
Identities = 87/295 (29%), Positives = 114/295 (38%), Gaps = 48/295 (16%)
Query: 4159 LCLLSPSGPVCT-----CPNGKRLDNGTCVPVPSPT--------PP----PDAP-RPGTC 4200
LC + GP C CP + GTC +P PP PD P C
Sbjct: 221 LCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNC 280
Query: 4201 -NLQCFNGGSCFLNARRQPKCRCQPRYTGDKC--ELDQCWE----HCRNGGTCAASPSGM 4253
+ QC NGG+C + C C +TG C ++D+C HCRNGGTC S +G
Sbjct: 281 VSHQCQNGGTC-QDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNS-AGS 338
Query: 4254 PTCRCPTGFTGPKCTQQV---CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC-- 4308
C C +G+ G C + + A CA STC G+ C C PG G C
Sbjct: 339 FHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSF-SCLCPPGRTGLLCHLEDMCL 397
Query: 4309 SGYCENFGTCQM-AADGSRQCRCTAYFEGSRC--EVNKC-------SRCLEGACVVNKQS 4358
S C C GS C C + G C ++++C S C G +N
Sbjct: 398 SQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTP- 456
Query: 4359 GDVTCNCTDGRVAPSCLT----CVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCE 4409
G C C G C C+ + GS ++ C CPP + G CE
Sbjct: 457 GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCE 511
Score = 85.5 bits (210), Expect = 1e-15
Identities = 66/232 (28%), Positives = 92/232 (39%), Gaps = 28/232 (12%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCEL-DQCWEH-CRNGGTCAASP-SGMPTCRCPT 4260
C G +C ++ C C P TG C L D C C C+ +P +G C C
Sbjct: 364 CAPGSTC-IDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQP 422
Query: 4261 GFTGPKCTQ--------QVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQC-S 4309
G++GP C Q Q C + +C +N C C PG+ G RC+ + +C S
Sbjct: 423 GYSGPTCHQDLDECLMAQQGPSPCEHGGSC-LNTPGSFNCLCPPGYTGSRCEADHNECLS 481
Query: 4310 GYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVT----CNC 4365
C TC + + C C EG CEV + + C C+ + D+ C C
Sbjct: 482 QPCHPGSTC-LDLLATFHCLCPPGLEGQLCEV-ETNECASAPCLNHADCHDLLNGFQCIC 539
Query: 4366 TDGRVAPSCLTCVGHC-----SNGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
G C + C +NGG C C+C P GPRC+ V
Sbjct: 540 LPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAF-HCKCLPGFEGPRCQTEV 590
Score = 80.1 bits (196), Expect = 5e-14
Identities = 158/621 (25%), Positives = 210/621 (33%), Gaps = 136/621 (21%)
Query: 2481 PCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINF 2540
PC NGG CL G C C G + + TC+ + AQ C NG
Sbjct: 34 PCA--NGGT---CLSLSLGQGTCQCAPGFLGE---TCQFPDPCQNAQ---LCQNGGSCQA 82
Query: 2541 SLTCD-GVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDG--SDE 2597
L G+P S PS+ + C F + RC + + D C S
Sbjct: 83 LLPAPLGLP--SSPSPLTPSFLCT--CLPGF---TGERCQAKL-----EDPCPPSFCSKR 130
Query: 2598 IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSAT--DCSSYFRLGVKGV 2655
C+ A G + C G G + F + C AT + G +G
Sbjct: 131 GRCHIQASGRPQCSCMPGWT-GEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEG- 188
Query: 2656 LFQPCER-TSLCYAPSWVCDGANDCGDYSDERDC---PGVKRPRCPLNYFACPSGRCIPM 2711
CER + C+ C C + C G + PRC L CP C
Sbjct: 189 --HACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGC-SN 245
Query: 2712 SWTCDKEDDCEHGEDETHC-----NKFCSEAQFECQNHRCISKQWLCDGSD--------- 2757
TC + + C C C +H+C + DG D
Sbjct: 246 GGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPET 305
Query: 2758 ----DCGDGSDEAA-----HCE-GKTCGPS--SFSCPGTHVCVPERWLCDGDKDCADGAD 2805
DC + DE HC G TC S SF C VCV W G C + D
Sbjct: 306 WTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHC----VCV-SGW---GGTSCEENLD 357
Query: 2806 ESIAAGCLYNSTCDDR--EFMCQNRQCIPKH--FVCDHDRDCADGSDESPECEYPTCGPS 2861
+ IAA C STC DR F C C P +C + C S C
Sbjct: 358 DCIAATCAPGSTCIDRVGSFSCL---CPPGRTGLLCHLEDMCL-----SQPCH------G 403
Query: 2862 EFRCANGRCLSSRQWECD---GENDCHDQSDE---APKNPHCTSQEHKC-NASSQFLC-- 2912
+ +C+ S C CH DE A + P C N F C
Sbjct: 404 DAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLC 463
Query: 2913 ----SSGRCVAEALLCNGQDD----------------CGDSSDERGCHI--NECLSRKLS 2950
+ RC A+ C Q C + + C + NEC S
Sbjct: 464 PPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCL 523
Query: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC-ADVDECSTTFPCSQ--RCINTHGSYKCLC 3007
+ DC DL GF+C C PGF G C D+DEC ++ PC+ +C + G++ C C
Sbjct: 524 NHA-DCHDLLNGFQCICLPGF----SGTRCEEDIDECRSS-PCANGGQCQDQPGAFHCKC 577
Query: 3008 VEGY-APRGGDPHSCKAVTDE 3027
+ G+ PR C+ DE
Sbjct: 578 LPGFEGPR------CQTEVDE 592
Score = 70.5 bits (171), Expect = 4e-11
Identities = 142/616 (23%), Positives = 202/616 (32%), Gaps = 153/616 (24%)
Query: 3290 PNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKND----- 3344
P P +NGG L H C CP F +G D NC + Q C+N
Sbjct: 237 PCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGF-IGPDCEVNPDNCVSHQ--CQNGGTCQD 293
Query: 3345 -------KCIPFW--WKCDTE-DDCGDHSDEPPDCPE---FKCRPGQFQCSTGICTNPAF 3391
C W W C + D+C + PP C + G F C +C +
Sbjct: 294 GLDTYTCLCPETWTGWDCSEDVDEC--ETQGPPHCRNGGTCQNSAGSFHC---VCVSGW- 347
Query: 3392 ICDGDNDCQDNSDEANCDIHVCLP--------SQFKCTNTNRCIPGI--FRCNGQDNCGD 3441
G C++N D+ C C P F C C PG C+ +D C
Sbjct: 348 ---GGTSCEENLDD--CIAATCAPGSTCIDRVGSFSCL----CPPGRTGLLCHLEDMCLS 398
Query: 3442 GEDERDCPEVTCAPNQFQCSITKRCIPRVW--VCDRD-NDCVDGSDEPANCTQMTCGVDE 3498
D C+ N S C P C +D ++C+ P+
Sbjct: 399 QPCHGD---AQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPS----------- 444
Query: 3499 FRCKDSGRCI--PARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCD 3556
C+ G C+ P + C C G + CE C + C PG
Sbjct: 445 -PCEHGGSCLNTPGSFNC----LCPPGYTGSR-------CEADHNECLSQPCHPG----- 487
Query: 3557 YDNDCGDNSDEESCTPRP------CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCT 3610
+ C D C P C CA+ C+ C HD +G + C
Sbjct: 488 --STCLDLLATFHCLCPPGLEGQLCEVETNECASAPCL-NHADC---HDLLNGF-QCICL 540
Query: 3611 P-----RCDMDQFQCKSGHCI--------PLRWRCDADADCMDGSDEEACGTGVRTCPLD 3657
P RC+ D +C+S C P + C C+ G + C T V C D
Sbjct: 541 PGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHC----KCLPGFEGPRCQTEVDECLSD 596
Query: 3658 EFQCN-NTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRV-CLWIGRQ 3715
+ L P A+ C E P CA +C P + + + D+ CL
Sbjct: 597 PCPVGASCLDLPGAFFCLCPSGFTGQLCEVP-LCAPNLCQPKQICKDQKDKANCL----- 650
Query: 3716 CDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEED 3775
C DG+ C PP + T C + C SS C++ G +
Sbjct: 651 ------CPDGS--PGCAPPEDNCT---------CHHGHCQRSSCVCDV------GWTGPE 687
Query: 3776 CSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTC- 3834
C + +L C ++ C C C C +G+ P C + G C
Sbjct: 688 C--EAELGGCI--SAPCAHGGTCYPQPSGYNCTCPTGY----TGPTCSEEMTACHSGPCL 739
Query: 3835 -SQLCNNTKGGHLCSC 3849
CN + GG+ C+C
Sbjct: 740 NGGSCNPSPGGYYCTC 755
Score = 65.9 bits (159), Expect = 9e-10
Identities = 46/159 (28%), Positives = 58/159 (36%), Gaps = 45/159 (28%)
Query: 4276 CANNSTCTVNQGNQPQCRCLPGFLGDRCQYR---QCSGYCENFGTCQMAADG-------- 4324
CAN TC Q C+C PGFLG+ CQ+ Q + C+N G+CQ
Sbjct: 35 CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94
Query: 4325 -----SRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVG 4379
S C C F G RC+ LE C PS
Sbjct: 95 SPLTPSFLCTCLPGFTGERCQAK-----LEDPC------------------PPS------ 125
Query: 4380 HCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQP 4418
CS G C + + P+C C P TG +C+ F P
Sbjct: 126 FCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANP 164
Score = 62.4 bits (150), Expect = 1e-08
Identities = 155/668 (23%), Positives = 206/668 (30%), Gaps = 233/668 (34%)
Query: 2473 DTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC 2532
D N C PC + C DL H C C G L+ L C + EC
Sbjct: 475 DHNECLSQPCHPGST-CLDLLATFH-----CLCPPG--LEGQL--------CEVETN-EC 517
Query: 2533 ANGECINFSLTCDGVPHCKDKSDEKPSYC----NSRRCKKTFRQCSNGRCVSNMLWCNGA 2588
A+ C+N + C D + C + RC++ +C + C NG
Sbjct: 518 ASAPCLNHA-------DCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCA------NGG 564
Query: 2589 DDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVD-CEDASDEMNCSATDC-SS 2646
C D C +C G RC VD C + S D +
Sbjct: 565 Q-CQDQPGAFHC----------KCLPGF---EGPRCQTEVDECLSDPCPVGASCLDLPGA 610
Query: 2647 YFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDC------PGVKRPR--CPL 2698
+F L G Q CE LC AP+ +C C D D+ +C PG P C
Sbjct: 611 FFCLCPSGFTGQLCE-VPLC-APN-LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTC 667
Query: 2699 NYFACPSGRCI-PMSWT---CDKE------DDCEHGED-------------ETHCNKFCS 2735
++ C C+ + WT C+ E C HG + CS
Sbjct: 668 HHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCS 727
Query: 2736 EAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS----FSCPGTHVCVPER 2791
E C + C++ G +C PS +CP +H
Sbjct: 728 EEMTACHSGPCLN----------------------GGSCNPSPGGYYCTCPPSHT----- 760
Query: 2792 WLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESP 2851
C D ++A C TC +R P F C CA G + P
Sbjct: 761 -----GPQCQTSTDYCVSAPCFNGGTCVNR----------PGTFSCL----CAMGF-QGP 800
Query: 2852 ECE---YPTCGPSEFR----CANG----RCLSSRQW---ECDGENDCHDQSDEAPKNPHC 2897
CE P+C S R C + RCL + C D Q P+N HC
Sbjct: 801 RCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKP-CPRNSHC 859
Query: 2898 TSQEHKCNASSQFLCSSG-----------RCVAEAL--------LCNGQDDCGDSSDERG 2938
+ S LC G C AL LC+ C DS
Sbjct: 860 L----QTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYF 915
Query: 2939 CH-------------INECLSR------------------------------KLSGC-SQ 2954
CH +N C SR +L C SQ
Sbjct: 916 CHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQ 975
Query: 2955 DCEDLKI------GFKCRCRPGFRLKDDGRTC-ADVDECSTTFPC----SQRCINTHGSY 3003
C + GF C C PGF G C DVDEC PC + C + ++
Sbjct: 976 PCHNHGTCTPKPGGFHCACPPGF----VGLRCEGDVDECLDQ-PCHPTGTAACHSLANAF 1030
Query: 3004 KCLCVEGY 3011
C C+ G+
Sbjct: 1031 YCQCLPGH 1038
Score = 62.0 bits (149), Expect = 1e-08
Identities = 150/687 (21%), Positives = 213/687 (31%), Gaps = 134/687 (19%)
Query: 3278 LHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG------GGHKCACPTNF---YLGSDGR 3328
L FH L P + C+V C++ L+ G +C C F D
Sbjct: 494 LATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDID 553
Query: 3329 TCVSNCTASQFVCKND------KCIPFWW--KCDTE-DDCGDHSDEPPDCPEFKCRPGQF 3379
C S+ A+ C++ KC+P + +C TE D+C SD P PG F
Sbjct: 554 ECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDEC--LSDPCPVGASCLDLPGAF 611
Query: 3380 QC-----STG-ICTNPAF---ICDGDNDCQDNSDEANC----DIHVCLPSQFKCTNTNRC 3426
C TG +C P +C C+D D+ANC C P + CT C
Sbjct: 612 FCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCT----C 667
Query: 3427 IPGIFRCNGQD-NCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
G C C G +C C+ C P+ + C G
Sbjct: 668 HHG--HCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ--PSGYNCTCPTGYTG 723
Query: 3486 PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKN 3545
P C++ C + G C P+ G C +C T C N
Sbjct: 724 P-TCSEEMTACHSGPCLNGGSCNPS----PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFN 778
Query: 3546 -NRCV--PGRWQC----DYDNDCGDNSDEESCTPRPCSE-------------------SE 3579
CV PG + C + + SC PC +
Sbjct: 779 GGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTG 838
Query: 3580 FSCANGRCIAGRWKCDGDHDCADGSDEKDCT-------PRCDMDQFQCKS---GHCIPLR 3629
SC + + C + C C P C++ C+ I +
Sbjct: 839 GSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVS 898
Query: 3630 WRCDADADCMDGSDEEAC----GTGVRTC-----PLDEFQCNN---TLCKPLAWKC---- 3673
C C+D C G C P + C N + +P + C
Sbjct: 899 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAP 958
Query: 3674 --DGE------DDCGDNSDENPEECA------RFVCPPN-RPFRCKND-RVCLWIGRQCD 3717
DG+ D C N C CPP RC+ D CL
Sbjct: 959 GYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPT 1018
Query: 3718 GTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCL-------SSSLRCNMFDDCGDG 3770
GT C + C+ HT + + C +Q C ++ C G
Sbjct: 1019 GTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKG 1078
Query: 3771 SDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAY---CACRSGFH-----TVPGQPGC 3822
+ CS + SC + C C+ + K + CAC SG+ T P GC
Sbjct: 1079 FEGPTCS--HRAPSCGFHH--CHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGC 1134
Query: 3823 QDINECLRFGTCSQLCNNTKGGHLCSC 3849
+ CL G+CS+ G CSC
Sbjct: 1135 GPPSPCLYNGSCSETTGLGGPGFRCSC 1161
Score = 62.0 bits (149), Expect = 1e-08
Identities = 84/346 (24%), Positives = 109/346 (31%), Gaps = 116/346 (33%)
Query: 4149 NPCDRKKCE--WLCLLSPSGPVCTCPNG-------KRLD---------NGTCVPVPS--- 4187
NPC+ + C+ C+ PSG +C C G K LD +GTC P P
Sbjct: 932 NPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFH 991
Query: 4188 -PTPPP--------------DAP--------------------RPG-----------TCN 4201
PP D P PG C+
Sbjct: 992 CACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCH 1051
Query: 4202 LQ-CFNGGSCFLNARRQPK--CRCQPRYTGDKCE--LDQC-WEHCRNGGTCAASPSG--M 4253
Q CF+GG+C A C C + G C C + HC +GG C SP
Sbjct: 1052 SQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFP 1111
Query: 4254 PTCRCPTGFTGPKCTQQVCAGYCANNSTCTVN---------QGNQPQCRCLPGFLGDRCQ 4304
P C C +G+ GP C C S C N G +C C G RCQ
Sbjct: 1112 PRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171
Query: 4305 YRQCSGYCENFGTCQMAADGSRQCRCT---AYFEGSRCEVN---------KCSRC----L 4348
G CE + DG+ C+ ++G C + SRC
Sbjct: 1172 KPGAKG-CEG-----RSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFR 1225
Query: 4349 EGACVVNKQSGDVTCNCTDGRVAPSCLTCV----------GHCSNG 4384
+G C S + + D P+C GHC G
Sbjct: 1226 DGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKG 1271
Score = 58.9 bits (141), Expect = 1e-07
Identities = 149/651 (22%), Positives = 199/651 (30%), Gaps = 143/651 (21%)
Query: 3284 LRQPDVPNHPCKVNNGGCSNLCLLSPG-GGHKCACPTNFYL------------------- 3323
L QP + C N S LCL PG G C + L
Sbjct: 397 LSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTP 456
Query: 3324 GSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGD-----HSDEPPDCPEFKCRPGQ 3378
GS C T S+ +++C+ C C D H PP C
Sbjct: 457 GSFNCLCPPGYTGSRCEADHNECLS--QPCHPGSTCLDLLATFHCLCPPGLEGQLCEVET 514
Query: 3379 FQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDN 3438
+C++ C N A DC D + C +CLP + RC I C
Sbjct: 515 NECASAPCLNHA-------DCHDLLNGFQC---ICLPG----FSGTRCEEDIDECRSSP- 559
Query: 3439 CGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDE 3498
C +G +D P F C +C+P C DE C C V
Sbjct: 560 CANGGQCQD------QPGAFHC----KCLPGF----EGPRCQTEVDE---CLSDPCPVGA 602
Query: 3499 FRCKDSGRCIPARWKCDGEDDCGDGSDEPKEE---CDERTCEPYQFRCKNNRCVPGRWQC 3555
C D +P + C C G E C C+P Q CK+ +
Sbjct: 603 -SCLD----LPGAFFC----LCPSGFTGQLCEVPLCAPNLCQPKQI-CKDQKDKANCLCP 652
Query: 3556 DYDNDCGDNSDEESCTPRPCSESEFSC-----------ANGRCIAGRWKCDGDHDCADGS 3604
D C D +C C S C G CI+ C C
Sbjct: 653 DGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISA--PCAHGGTCYPQP 710
Query: 3605 DEKDCT-------PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLD 3657
+CT P C + C SG C+ GS + G TCP
Sbjct: 711 SGYNCTCPTGYTGPTCSEEMTACHSGPCL------------NGGSCNPSPGGYYCTCPPS 758
Query: 3658 EF--QCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQ 3715
QC + ++ C C + CA P RC+
Sbjct: 759 HTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGP----RCEGKLRPSCADSP 814
Query: 3716 CDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLC------RNQRCLSS--SLRCNMFDDC 3767
C C D C PT +T LC RN CL + S C C
Sbjct: 815 CRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCL----C 870
Query: 3768 GDGSDEEDCSIDPKLTSCATNA--------SICGDEARCVRTEKAAYCACRSGFHTVPGQ 3819
G C++ L+SC A S+C + CV + + +C C GF
Sbjct: 871 LQGWTGPLCNL--PLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQ----G 924
Query: 3820 PGCQD-INEC-LRFGTCSQLCNNTKGGHLCSCA-----RNFMKTHNTCKAE 3863
CQD +N C R C G+LC CA +N K + C+++
Sbjct: 925 SLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQ 975
Score = 47.4 bits (111), Expect = 3e-04
Identities = 37/134 (27%), Positives = 48/134 (35%), Gaps = 17/134 (12%)
Query: 47 CDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE-LCVPMSRLCNGVQDCMDGSDEG 105
C ++ C D D+A +CP + C P E NC C S +C D G
Sbjct: 634 CQPKQICKDQKDKANCLCPDG-SPGCAPPEDNCTCHHGHCQRSSCVC-------DVGWTG 685
Query: 106 PHCRELQGNCSRLGCQH--HCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTC--S 161
P C G C C H C P G C C + + G TC + G C
Sbjct: 686 PECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGY----TGPTCSEEMTACHSGPCLNG 741
Query: 162 QLCTNTDGSFICGC 175
C + G + C C
Sbjct: 742 GSCNPSPGGYYCTC 755
Score = 46.2 bits (108), Expect = 7e-04
Identities = 116/586 (19%), Positives = 171/586 (29%), Gaps = 156/586 (26%)
Query: 805 NKCRVNNGGCSSLCLATPGSRQCACA---EDQVLDADGVTCLANPSYVPPPQCQ-PGEFA 860
++CR + C PG+ C C E + CL++P V PG F
Sbjct: 553 DECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFF 612
Query: 861 C------ANSRC---IQERWKCDGDNDCLDNSDEAPALCHQHT--C--PSDRFKCENNRC 907
C C + C C D D+A LC + C P D C + C
Sbjct: 613 CLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHC 672
Query: 908 IPNRWLCD---------------------GDNDCGNSEDESNATC----SARTCPPNQFS 942
+ +CD C N TC + TC +
Sbjct: 673 QRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTA 732
Query: 943 CASGRCI--------PISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCIN--- 991
C SG C+ P + C S C T + ++ N G C+N
Sbjct: 733 CHSGPCLNGGSCNPSPGGYYCTCPP-----SHTGPQCQTSTDYCVSAPCFNGGTCVNRPG 787
Query: 992 -----------------------INWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCI 1028
+ C N C D+ C T C + +
Sbjct: 788 TFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDL 847
Query: 1029 PEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLC--IPLRWRCDGDT 1086
C ++ C H C T P C+ C+ L I + C
Sbjct: 848 CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPL--CNLPLSSCQKAALSQGIDVSSLCHNGG 905
Query: 1087 DCMDSSDEKSCEGVT---------HVCDPSVKFGCKDSARCISK--AWVCDGDNDCEDNS 1135
C+DS C HV +P C++ A C+++ ++C C
Sbjct: 906 LCVDSGPSYFCHCPPGFQGSLCQDHV-NPCESRPCQNGATCMAQPSGYLCQ----CAPGY 960
Query: 1136 DEENCESLACRPPSHPCANNTSVCLPPDKL------------CDGN-DDCGDG------- 1175
D +NC S PC N+ + P C+G+ D+C D
Sbjct: 961 DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGT 1020
Query: 1176 ----------------SDEGELC----DQCSLNNGGCSHN--CSVAPGE--GIVCSCPLG 1211
G+ C D C ++ C H C G G +C CP G
Sbjct: 1021 AACHSLANAFYCQCLPGHTGQWCEVEIDPC--HSQPCFHGGTCEATAGSPLGFICHCPKG 1078
Query: 1212 MELGPDNHTCQIQSYCAKHLKCSQ-----KCDQNKFSVKCSCYEGW 1252
E GP TC ++ C + F +C+C G+
Sbjct: 1079 FE-GP---TCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGY 1120
Score = 44.3 bits (103), Expect = 0.003
Identities = 116/513 (22%), Positives = 165/513 (32%), Gaps = 104/513 (20%)
Query: 803 GTNKCRVNNGGCSSLCLATPGSRQCACAE--DQVLDAD--------GVTCLANP---SYV 849
G +C N S+LCL PG C + D+ L A G +CL P + +
Sbjct: 403 GDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCL 462
Query: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLD---------------------NSDEAPA 888
PP ++ C+ + C + CLD ++ A A
Sbjct: 463 CPPGYTGSRCEADHNECLSQ--PCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASA 520
Query: 889 LCHQHTCPSDRFKCENNRCIP--NRWLCDGD-NDCGNSEDESNATCSARTCPPNQFSCAS 945
C H D C+P + C+ D ++C +S + C + P F C
Sbjct: 521 PCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQ---PGAFHC-- 575
Query: 946 GRCIP----ISWTCDLDDDCGDRSDESASCA-YPTCF------PLTQFTCNNGRCI-NIN 993
+C+P ++D+ D ASC P F T C C N+
Sbjct: 576 -KCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNL- 633
Query: 994 WRCDNDNDCGDNSDEAGC-----SHSCSSTQ--FKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
C C D D+A C S C+ + C+ G C C D G E
Sbjct: 634 --CQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVC----DVGWTGPE 687
Query: 1047 THANCTNQATRPPGGCHTDEFQCRLDGLCI--PLRWRCDGDTDCMDSSDEKSCEGVTHVC 1104
A GGC + C G C P + C C +C C
Sbjct: 688 CEAEL--------GGCIS--APCAHGGTCYPQPSGYNC----TCPTGYTGPTCSEEMTAC 733
Query: 1105 DPSVKFGCKDSARCISK--AWVCDGDNDCEDNSDEENCESLACRPPSHPCAN-NTSVCLP 1161
C + C + C C + C++ S PC N T V P
Sbjct: 734 HSG---PCLNGGSCNPSPGGYYC----TCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRP 786
Query: 1162 PDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTC 1221
C EG+L C+ + C +P +G C CP G G +C
Sbjct: 787 GTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSP-QGPRCLCPTGYTGG----SC 841
Query: 1222 Q-IQSYCA-KHLKCSQKCDQNKFSVKCSCYEGW 1252
Q + CA K + C Q S C C +GW
Sbjct: 842 QTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGW 874
Score = 43.9 bits (102), Expect = 0.004
Identities = 93/421 (22%), Positives = 129/421 (30%), Gaps = 101/421 (23%)
Query: 805 NKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQC--------QP 856
N C + C+A P C CA DG C C +P
Sbjct: 932 NPCESRPCQNGATCMAQPSGYLCQCAPGY----DGQNCSKELDACQSQPCHNHGTCTPKP 987
Query: 857 GEFACANSRCIQERWKCDGDND-CLDNS--DEAPALCHQHTCPSDRFKCENNRCIPN--- 910
G F CA +C+GD D CLD A CH ++ F C+ C+P
Sbjct: 988 GGFHCACPPGFVGL-RCEGDVDECLDQPCHPTGTAACHSL---ANAFYCQ---CLPGHTG 1040
Query: 911 RWLCDGDND-CGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESA 969
+W C+ + D C + TC A P F C C + S +
Sbjct: 1041 QW-CEVEIDPCHSQPCFHGGTCEATAGSPLGFICH----------CPKGFEGPTCSHRAP 1089
Query: 970 SCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIP 1029
SC + C + G C+ S + G C+ C SG P
Sbjct: 1090 SCGFHHCH-------HGGLCLP--------------SPKPGFPPRCA-----CLSGYGGP 1123
Query: 1030 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCM 1089
+ T CG S + ++ T G F+C R + G C
Sbjct: 1124 DCLTPPAPKGCGPPSPCLYNGSCSETT----GLGGPGFRCSCPHSSPGPRCQKPGAKGCE 1179
Query: 1090 DSSDEKSCE------------GVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDE 1137
S + +C+ G + P GC +RC W+ D C D
Sbjct: 1180 GRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRC----WLLFRDGQCHPQCDS 1235
Query: 1138 ENC--ESLACRPPSHPCANNTSVCLPP-DKLCDG---NDDCGDGSDEGELCDQCSLNNGG 1191
E C + C P C P D+ C N C G + E C + G
Sbjct: 1236 EECLFDGYDCETP--------PACTPAYDQYCHDHFHNGHCEKGCNTAE----CGWDGGD 1283
Query: 1192 C 1192
C
Sbjct: 1284 C 1284
Score = 43.1 bits (100), Expect = 0.006
Identities = 47/163 (28%), Positives = 60/163 (36%), Gaps = 21/163 (12%)
Query: 33 AC-RDQITCISKGWRCDGERDCPDGSDEAPEICP--------QSKAQRCQPNEHNCLGTE 83
AC RD C C C + +CP + +A C P + GT
Sbjct: 190 ACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTC 249
Query: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHH--CVPTLDGPTCYCNSSFQL 141
+P + C G GP C NC CQ+ C LD TC C ++
Sbjct: 250 QLMPEKDSTFHLCLCPPGFI-GPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWT- 307
Query: 142 QADGKTC-KDFDECSVYGT--CSQ--LCTNTDGSFICGCVEGY 179
G C +D DEC G C C N+ GSF C CV G+
Sbjct: 308 ---GWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGW 347
Score = 40.8 bits (94), Expect = 0.031
Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 17/127 (13%)
Query: 63 ICPQS-KAQRCQPNEHNCLGTELCVPMSRLCNGVQD----CMDGSDEGPHCRELQGNCSR 117
+CP RC+ + + CL ++ C P S + + C G EG C C+
Sbjct: 462 LCPPGYTGSRCEADHNECL-SQPCHPGSTCLDLLATFHCLCPPGL-EGQLCEVETNECAS 519
Query: 118 LGCQHH--CVPTLDGPTCYCNSSFQLQADGKTCK-DFDECSVYGTCSQ--LCTNTDGSFI 172
C +H C L+G C C F G C+ D DEC C+ C + G+F
Sbjct: 520 APCLNHADCHDLLNGFQCICLPGFS----GTRCEEDIDECRS-SPCANGGQCQDQPGAFH 574
Query: 173 CGCVEGY 179
C C+ G+
Sbjct: 575 CKCLPGF 581
Score = 38.5 bits (88), Expect = 0.15
Identities = 39/163 (23%), Positives = 63/163 (38%), Gaps = 22/163 (13%)
Query: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKA-QRCQPNEHNCLGTEL 84
TCS + AC C++ G C CP S +CQ + C+
Sbjct: 725 TCSEEMTACHSG-PCLNGG-------SCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAP- 775
Query: 85 CVPMSRLCN--GVQDCMDGSD-EGPHCR-ELQGNCSRLGCQHH--CVPTLDGPTCYCNSS 138
C N G C+ +GP C +L+ +C+ C++ C + GP C C +
Sbjct: 776 CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTG 835
Query: 139 FQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGY 179
+ G +C+ + C + C T SF C C++G+
Sbjct: 836 YT----GGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGW 874
Score = 36.2 bits (82), Expect = 0.76
Identities = 59/233 (25%), Positives = 81/233 (34%), Gaps = 64/233 (27%)
Query: 2 LTPPLLLLLPLLSALVAAAIDAPK--TCSPKQFACRDQITCIS----------------- 42
+ PP LLLL LL L+ ++ P+ C C + TC+S
Sbjct: 1 MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGE 60
Query: 43 ---------------KGWRCDGERDCPDGSDEAPE------IC---PQSKAQRCQPNEHN 78
G C P G +P +C P +RCQ +
Sbjct: 61 TCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED 120
Query: 79 CLGTELCVPMSRLCNGVQ-------DCMDGSDEGPHCRELQGNCSRLGCQHH--CVPTLD 129
C R C+ +Q CM G G C +L+ CS C + C+ T
Sbjct: 121 PCPPSFCSKRGR-CH-IQASGRPQCSCMPGW-TGEQC-QLRDFCSANPCVNGGVCLATYP 176
Query: 130 GPTCYCNSSFQLQADGKTC-KDFDEC-SVYGTCSQ--LCTNTDGSFICGCVEG 178
C+C F +G C +D +EC G C + C NT GSF C C G
Sbjct: 177 QIQCHCPPGF----EGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 225
Score = 36.2 bits (82), Expect = 0.76
Identities = 29/113 (25%), Positives = 44/113 (38%), Gaps = 26/113 (23%)
Query: 86 VPMSRLCNGVQDCMDGSD----------EGPHCRELQGNCSRLGCQHH--CVPTLDGPTC 133
+ +S LC+ C+D +G C++ C CQ+ C+ G C
Sbjct: 895 IDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLC 954
Query: 134 YCNSSFQLQADGKTC-KDFDECSV-----YGTCSQLCTNTDGSFICGCVEGYL 180
C + DG+ C K+ D C +GTC T G F C C G++
Sbjct: 955 QCAPGY----DGQNCSKELDACQSQPCHNHGTC----TPKPGGFHCACPPGFV 999
Score = 35.8 bits (81), Expect = 1.00
Identities = 43/181 (23%), Positives = 56/181 (30%), Gaps = 38/181 (20%)
Query: 1102 HVCDPSVKFGCKDSARCISKAWVCDGDND-----CEDNSDEENCESLACRPPSHPCANNT 1156
H C+ V +D C K C C + CE A P C+N
Sbjct: 189 HACERDVNECFQDPGPC-PKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGG 247
Query: 1157 SVCLPPDK-------LCDGNDDCGDGSDEGELCDQCSLNNGGC-SHNCSVAPG-----EG 1203
+ L P+K LC G + C +N C SH C +
Sbjct: 248 TCQLMPEKDSTFHLCLCP----------PGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDT 297
Query: 1204 IVCSCP---LGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES 1260
C CP G + D C+ Q H + C + S C C GW G S
Sbjct: 298 YTCLCPETWTGWDCSEDVDECETQG--PPHCRNGGTCQNSAGSFHCVCVSGW----GGTS 351
Query: 1261 C 1261
C
Sbjct: 352 C 352
Score = 35.8 bits (81), Expect = 1.00
Identities = 71/329 (21%), Positives = 96/329 (29%), Gaps = 44/329 (13%)
Query: 795 YDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQC 854
YD Q + C+ C PG CAC V G+ C + C
Sbjct: 960 YDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFV----GLRCEGDVDECLDQPC 1015
Query: 855 QPGEFACANSRCIQERWKC-DGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWL 913
P A +S +C G + P CH C CE P ++
Sbjct: 1016 HPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDP--CHSQPC-FHGGTCEATAGSPLGFI 1072
Query: 914 C------DGDN------DCGNSEDESNATCSARTCP--PNQFSCASGRCIPISWTCDLDD 959
C +G CG C P P + +C SG P T
Sbjct: 1073 CHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPK 1132
Query: 960 DCGDRSD--ESASCAYPTCFPLTQFTCNNGRCININWRCDND--NDCGDNSDEAGCSHSC 1015
CG S + SC+ T F C+ + RC C S + C C
Sbjct: 1133 GCGPPSPCLYNGSCSETTGLGGPGFRCSCPHS-SPGPRCQKPGAKGCEGRSGDGACDAGC 1191
Query: 1016 SSTQFKCNSGRC---IPEHWT-CDGDNDCG--DYSDETHANCTNQATRPPGGCHTDEFQC 1069
S + G C +P+ W C + C + H C ++ C D + C
Sbjct: 1192 SGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEE------CLFDGYDC 1245
Query: 1070 RLDGLCIPLRWRCDGDTDCMDSSDEKSCE 1098
C P D C D CE
Sbjct: 1246 ETPPACTPAY-----DQYCHDHFHNGHCE 1269
Score = 34.3 bits (77), Expect = 2.9
Identities = 49/216 (22%), Positives = 70/216 (32%), Gaps = 27/216 (12%)
Query: 72 CQPNEHNCLGTELCVPMSRLCN--GVQDCMDGSDEGPHCRELQGNCSRLGC----QHHCV 125
C+ N +C+ C P S + G C+ L+ C C Q
Sbjct: 352 CEENLDDCIAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTN 410
Query: 126 PTLDGPTCYCNSSFQLQADGKTC-KDFDECSVY----GTCSQ--LCTNTDGSFICGCVEG 178
P C C + G TC +D DEC + C C NT GSF C C G
Sbjct: 411 PLTGSTLCLCQPGYS----GPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPG 466
Query: 179 YLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYA 238
Y C+A + P + ++LAT+ P Q ++ +
Sbjct: 467 Y----TGSRCEADHNECLSQPCHPGSTCLDLLATF-----HCLCPPGLEGQLCEVETNEC 517
Query: 239 NETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTIN 274
C H +C +PG G E I+
Sbjct: 518 ASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDID 553
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 132 bits (332), Expect = 8e-30
Identities = 79/226 (34%), Positives = 105/226 (46%), Gaps = 23/226 (10%)
Query: 2598 IPCNKTACGVGEFRCRD-GTCIGNSSRCNQFVDCEDASDEMNCS--ATDCSSYFRLGVKG 2654
+P AC EF C C+ RC++ DC D SDE+NC S F L V+
Sbjct: 192 VPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVET 251
Query: 2655 VLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR-CPLNYFACPSGRCIPMSW 2713
P T++ P ++ + PG RP C AC +G CIP +
Sbjct: 252 TSLPPRPETTIMRQPPVT---------HAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDY 302
Query: 2714 TCDKEDDCEHGEDETHCN--KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG 2771
CD ++DCE G DE C C +F C N C K W CDG DC D +DE A+C
Sbjct: 303 LCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE-ANCPT 361
Query: 2772 K----TCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCL 2813
K CGP+ F C T++C+P + CD + DC D +DE GC+
Sbjct: 362 KRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE---FGCM 404
Score = 132 bits (331), Expect = 1e-29
Identities = 79/234 (33%), Positives = 102/234 (43%), Gaps = 14/234 (5%)
Query: 3494 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRW 3553
C EF C C+ ++CD DC D SDE E P +P R
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3554 QCDYDNDCGDNSDEE-----SCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKD 3608
+ + S P PC E +C NG CI + CDG DC DGSDE D
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 3609 C--TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGT--GVRTCPLDEFQCNNT 3664
C P C+ ++F C +GHC WRCD D DC D +DE C T C +F+C +T
Sbjct: 319 CGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVST 378
Query: 3665 -LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDR----VCLWIG 3713
+C P ++ CD E DC D SDE + V PP + + C+ IG
Sbjct: 379 NMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIG 432
Score = 128 bits (321), Expect = 1e-28
Identities = 75/211 (35%), Positives = 110/211 (52%), Gaps = 11/211 (5%)
Query: 2734 CSEAQFECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPS-SFSCPGTHVCVPER 2791
C+EA+F C ++ C++ ++ CD DC D SDE +CE G S +FS +P R
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDEL-NCEEPVLGISPTFSLLVETTSLPPR 257
Query: 2792 -WLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDES 2850
+ A + + G + C +E C+N CIP+ ++CD DC DGSDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 2851 PECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHC-TSQEHKCNASSQ 2909
P C P+EF C NG C + + W CDG+ DC D++DEA +C T + + +Q
Sbjct: 318 DCGPPPPCEPNEFPCGNGHC-ALKLWRCDGDFDCEDRTDEA----NCPTKRPEEVCGPTQ 372
Query: 2910 FLC-SSGRCVAEALLCNGQDDCGDSSDERGC 2939
F C S+ C+ + C+ + DC D SDE GC
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 124 bits (312), Expect = 2e-27
Identities = 73/210 (34%), Positives = 103/210 (49%), Gaps = 14/210 (6%)
Query: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC--PEVTCAPNQFQCSITKRCIPRV 3470
C ++F C + N C+ +RC+ + +C D DE +C P + +P T PR
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3471 WVCDRDNDCVDGSDE---PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEP 3527
V + + P + + CG E C+ +G CIP + CDG++DC DGSDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-NGHCIPRDYLCDGQEDCEDGSDE- 316
Query: 3528 KEEC-DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC-TPRP---CSESEFSC 3582
+C CEP +F C N C W+CD D DC D +DE +C T RP C ++F C
Sbjct: 317 -LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 3583 -ANGRCIAGRWKCDGDHDCADGSDEKDCTP 3611
+ CI + CD + DC D SDE C P
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMP 405
Score = 118 bits (295), Expect = 2e-25
Identities = 71/217 (32%), Positives = 94/217 (43%), Gaps = 52/217 (23%)
Query: 3572 PRPCSESEFSCAN-GRCIAGRWKCDGDHDCADGSDEKDCT-------------------- 3610
PR C+E+EF+C + C+A ++CD DC D SDE +C
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 3611 PR---------------------------CDMDQFQCKSGHCIPLRWRCDADADCMDGSD 3643
PR C + C++GHCIP + CD DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 3644 EEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN--PEECARFVCPPNRPF 3701
E CG C +EF C N C W+CDG+ DC D +DE P + VC P + F
Sbjct: 316 ELDCGPPP-PCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ-F 373
Query: 3702 RCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHT 3738
RC + +C+ CD +C D +DE C PP T
Sbjct: 374 RCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVT 410
Score = 116 bits (291), Expect = 4e-25
Identities = 54/130 (41%), Positives = 71/130 (54%), Gaps = 6/130 (4%)
Query: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFIC 3393
C + C+N CIP + CD ++DC D SDE P C P +F C G C + C
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRC 344
Query: 3394 DGDNDCQDNSDEANCDI----HVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC- 3448
DGD DC+D +DEANC VC P+QF+C +TN CIP F C+ + +C D DE C
Sbjct: 345 DGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCM 404
Query: 3449 -PEVTCAPNQ 3457
P+V P +
Sbjct: 405 PPQVVTPPRE 414
Score = 116 bits (290), Expect = 6e-25
Identities = 81/249 (32%), Positives = 104/249 (41%), Gaps = 21/249 (8%)
Query: 851 PPQCQPGEFACAN-SRCIQERWKCDGDNDCLDNSDEAPALCHQHTC---PSDRFKCENNR 906
P C EFAC + + C+ ++CD DC D SDE C + P+ E
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELN--CEEPVLGISPTFSLLVETTS 253
Query: 907 CIPNRWLCDGDNDCGNSEDESNATCSART--CPPNQFSCASGRCIPISWTCDLDDDCGDR 964
P + S R C P + +C +G CIP + CD +DC D
Sbjct: 254 LPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313
Query: 965 SDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGC-----SHSCSSTQ 1019
SDE P C P +F C NG C WRCD D DC D +DEA C C TQ
Sbjct: 314 SDELDCGPPPPCEP-NEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372
Query: 1020 FKC-NSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGC-----HTDEFQCRLDG 1073
F+C ++ CIP + CD ++DC D SDE T P T F C G
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIG 432
Query: 1074 LCIP-LRWR 1081
+ P + WR
Sbjct: 433 VPTPIINWR 441
Score = 113 bits (283), Expect = 4e-24
Identities = 72/211 (34%), Positives = 90/211 (42%), Gaps = 57/211 (27%)
Query: 3370 PEFK--CRPGQFQC-STGICTNPAFICDGDNDCQDNSDEANCDIHV-------------- 3412
P+F C +F C S C + CD DC+D SDE NC+ V
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 3413 --------------------------------CLPSQFKCTNTNRCIPGIFRCNGQDNCG 3440
C P + C N CIP + C+GQ++C
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN-GHCIPRDYLCDGQEDCE 311
Query: 3441 DGEDERDC-PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC----TQMTCG 3495
DG DE DC P C PN+F C C ++W CD D DC D +DE ANC + CG
Sbjct: 312 DGSDELDCGPPPPCEPNEFPCG-NGHCALKLWRCDGDFDCEDRTDE-ANCPTKRPEEVCG 369
Query: 3496 VDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526
+FRC + CIPA + CD E DC D SDE
Sbjct: 370 PTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 111 bits (278), Expect = 1e-23
Identities = 67/213 (31%), Positives = 87/213 (40%), Gaps = 55/213 (25%)
Query: 934 RTCPPNQFSCAS-GRCIPISWTCDLDDDCGDRSDESASCAYPT----------------- 975
R C +F+C S C+ + + CD DC D SDE +C P
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDE-LNCEEPVLGISPTFSLLVETTSLP 255
Query: 976 -----------------------------CFPLTQFTCNNGRCININWRCDNDNDCGDNS 1006
C P + C NG CI ++ CD DC D S
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGP-QEAACRNGHCIPRDYLCDGQEDCEDGS 314
Query: 1007 DEAGCSHS--CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHT 1064
DE C C +F C +G C + W CDGD DC D +DE ANC + RP C
Sbjct: 315 DELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE--ANCPTK--RPEEVCGP 370
Query: 1065 DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSC 1097
+F+C +CIP + CD ++DC D SDE C
Sbjct: 371 TQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 109 bits (273), Expect = 5e-23
Identities = 62/203 (30%), Positives = 86/203 (42%), Gaps = 52/203 (25%)
Query: 3334 CTASQFVCKN-DKCIPFWWKCDTEDDCGDHSDE--------------------------- 3365
CT ++F C + ++C+ ++CD DC D SDE
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3366 ------------------PPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEAN 3407
P C P + C G C ++CDG DC+D SDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 3408 C-DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC----PEVTCAPNQFQCSI 3462
C C P++F C N C ++RC+G +C D DE +C PE C P QF+C
Sbjct: 319 CGPPPPCEPNEFPCGN-GHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS 377
Query: 3463 TKRCIPRVWVCDRDNDCVDGSDE 3485
T CIP + CD ++DC D SDE
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDE 400
Score = 109 bits (272), Expect = 7e-23
Identities = 65/218 (29%), Positives = 87/218 (39%), Gaps = 59/218 (27%)
Query: 973 YPTCFPLTQFTCNN-GRCININWRCDNDNDCGDNSDEAGCSHS----------------- 1014
+P +F C++ C+ + +RCD DC D SDE C
Sbjct: 195 FPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSL 254
Query: 1015 ------------------------------CSSTQFKCNSGRCIPEHWTCDGDNDCGDYS 1044
C + C +G CIP + CDG DC D S
Sbjct: 255 PPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGS 314
Query: 1045 DETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSC--EGVTH 1102
DE PP C +EF C +G C WRCDGD DC D +DE +C +
Sbjct: 315 DELDCG-------PPPPCEPNEFPCG-NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE 366
Query: 1103 VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
VC P+ +F C + CI ++ CD ++DC D SDE C
Sbjct: 367 VCGPT-QFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 105 bits (261), Expect = 1e-21
Identities = 70/208 (33%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 1014 SCSSTQFKCNS-GRCIPEHWTCDGDNDCGDYSDETHAN---------------CTNQATR 1057
+C+ +F C+S C+ + CD DC D SDE + T+ R
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 1058 P------------------PGG-----CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDE 1094
P PG C E CR +G CIP + CDG DC D SDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-NGHCIPRDYLCDGQEDCEDGSDE 316
Query: 1095 KSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESL----ACRPPSH 1150
C G C+P+ +F C + C K W CDGD DCED +DE NC + C P
Sbjct: 317 LDC-GPPPPCEPN-EFPC-GNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQF 373
Query: 1151 PCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
C +T++C+P CD DC D SDE
Sbjct: 374 RCV-STNMCIPASFHCDEESDCPDRSDE 400
Score = 104 bits (259), Expect = 2e-21
Identities = 54/125 (43%), Positives = 60/125 (48%), Gaps = 4/125 (3%)
Query: 846 PSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENN 905
P V P C P E AC N CI + CDG DC D SDE C + F C N
Sbjct: 277 PGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC-GPPPPCEPNEFPCGNG 335
Query: 906 RCIPNRWLCDGDNDCGNSEDESNATCS--ARTCPPNQFSCAS-GRCIPISWTCDLDDDCG 962
C W CDGD DC + DE+N C P QF C S CIP S+ CD + DC
Sbjct: 336 HCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCP 395
Query: 963 DRSDE 967
DRSDE
Sbjct: 396 DRSDE 400
Score = 87.8 bits (216), Expect = 2e-16
Identities = 50/156 (32%), Positives = 68/156 (43%), Gaps = 16/156 (10%)
Query: 803 GTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACA 862
G + NG C G C D+ LD PPP C+P EF C
Sbjct: 286 GPQEAACRNGHCIPRDYLCDGQEDCEDGSDE-LDCG-----------PPPPCEPNEFPCG 333
Query: 863 NSRCIQERWKCDGDNDCLDNSDEA--PALCHQHTCPSDRFKC-ENNRCIPNRWLCDGDND 919
N C + W+CDGD DC D +DEA P + C +F+C N CIP + CD ++D
Sbjct: 334 NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESD 393
Query: 920 CGNSEDESNATCSARTCPPNQFSCASGRCIPISWTC 955
C + DE PP + S + R +++TC
Sbjct: 394 CPDRSDEFGCMPPQVVTPPRE-SIQASRGQTVTFTC 428
Score = 87.4 bits (215), Expect = 3e-16
Identities = 60/206 (29%), Positives = 74/206 (35%), Gaps = 51/206 (24%)
Query: 2529 EFECAN-GECINFSLTCDGVPHCKDKSDEK------------------------------ 2557
EF C + EC+ CD P C+D SDE
Sbjct: 203 EFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTI 262
Query: 2558 --------------PSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCN-K 2602
P C C NG C+ C+G +DC DGSDE+ C
Sbjct: 263 MRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPP 322
Query: 2603 TACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCER 2662
C EF C +G C RC+ DCED +DE NC V G C
Sbjct: 323 PPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE-----VCGPTQFRCVS 377
Query: 2663 TSLCYAPSWVCDGANDCGDYSDERDC 2688
T++C S+ CD +DC D SDE C
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 81.3 bits (199), Expect = 2e-14
Identities = 64/211 (30%), Positives = 78/211 (36%), Gaps = 53/211 (25%)
Query: 3613 CDMDQFQCKS-GHCIPLRWRCDADADCMDGSDEEACGTGVR------------------- 3652
C +F C S C+ L +RCD DC D SDE C V
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 3653 -------------------------TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP 3687
C E C N C P + CDG++DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL- 317
Query: 3688 EECARFV-CPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKE 3746
+C C PN F C N L + R CDG +C D TDE +C PT +
Sbjct: 318 -DCGPPPPCEPNE-FPCGNGHCALKLWR-CDGDFDCEDRTDEANC--PTKRPEEVCGPTQ 372
Query: 3747 FLC-RNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
F C C+ +S C+ DC D SDE C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 71.6 bits (174), Expect = 2e-11
Identities = 34/82 (41%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQR-CQPNEHNCLGT 82
P C P +F C + C K WRCDG+ DC D +DEA CP + + C P + C+ T
Sbjct: 322 PPPCEPNEFPCGNG-HCALKLWRCDGDFDCEDRTDEAN--CPTKRPEEVCGPTQFRCVST 378
Query: 83 ELCVPMSRLCNGVQDCMDGSDE 104
+C+P S C+ DC D SDE
Sbjct: 379 NMCIPASFHCDEESDCPDRSDE 400
Score = 63.9 bits (154), Expect = 3e-09
Identities = 54/192 (28%), Positives = 69/192 (35%), Gaps = 50/192 (26%)
Query: 3652 RTCPLDEFQCNN-TLCKPLAWKCDGEDDCGDNSDE-NPEECARFVCP-----------PN 3698
R C EF C++ C L ++CD DC D SDE N EE + P P
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 3699 RP-------------------------------FRCKNDRVCLWIGRQCDGTDNCGDGTD 3727
RP C+N C+ CDG ++C DG+D
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGH-CIPRDYLCDGQEDCEDGSD 315
Query: 3728 EEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCAT 3787
E DC PP C + EF C N C RC+ DC D +DE +C C
Sbjct: 316 ELDCGPPPP----C-EPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGP 370
Query: 3788 NASICGDEARCV 3799
C C+
Sbjct: 371 TQFRCVSTNMCI 382
Score = 59.7 bits (143), Expect = 6e-08
Identities = 38/104 (36%), Positives = 48/104 (46%), Gaps = 14/104 (13%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
P C P++ ACR+ CI + + CDG+ DC DGSDE P C+PNE C G
Sbjct: 282 PLPCGPQEAACRNG-HCIPRDYLCDGQEDCEDGSDELDCGPPPP----CEPNEFPC-GNG 335
Query: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPT 127
C C+G DC D +DE NC + C PT
Sbjct: 336 HCALKLWRCDGDFDCEDRTDE--------ANCPTKRPEEVCGPT 371
Score = 52.8 bits (125), Expect = 8e-06
Identities = 57/232 (24%), Positives = 78/232 (33%), Gaps = 74/232 (31%)
Query: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDE------------------------ 59
P+ C+ +FAC C++ +RCD DC D SDE
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 60 ---------------APE-ICPQS-KAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGS 102
AP+ + P S + C P E C C+P LC+G +DC DGS
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGH-CIPRDYLCDGQEDCEDGS 314
Query: 103 DE-----GPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQ--ADGKTCKDFDECS 155
DE P C + C HC L C+ F + D C
Sbjct: 315 DELDCGPPPPCEPNEFPCG----NGHCALKL----WRCDGDFDCEDRTDEANCPTKRPEE 366
Query: 156 VYGTCSQLCTNTD----GSFIC-------------GCVEGYLLQPDNRSCKA 190
V G C +T+ SF C GC+ ++ P S +A
Sbjct: 367 VCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQA 418
Score = 52.0 bits (123), Expect = 1e-05
Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 20/120 (16%)
Query: 2499 GHVNCSCRGGRILQDDLTCRAVNSSCRAQDE-------------FECANGECINFSLTCD 2545
G +CR G + D C DE F C NG C CD
Sbjct: 286 GPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCD 345
Query: 2546 GVPHCKDKSDEKPSYCNSRR----CKKT-FRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2600
G C+D++DE + C ++R C T FR S C+ C+ DC D SDE C
Sbjct: 346 GDFDCEDRTDE--ANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 50.4 bits (119), Expect = 4e-05
Identities = 55/195 (28%), Positives = 76/195 (38%), Gaps = 40/195 (20%)
Query: 4169 CTCPNGKRLDNGTCVPVPSP-TPPPDAPRPGTCNLQCFNG---------GSC--FLNARR 4216
C+CP G R +C + T P GTC +G G+C +
Sbjct: 1126 CSCPPGYR--GPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTE 1183
Query: 4217 QPKC-RCQPRYTGDK-------CELDQCWEHCRNGG---TCAASPSGMPTC-RCPTGFTG 4264
P+C +CQP Y GD C+L C+ G TC G PTC C G +G
Sbjct: 1184 GPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSG 1243
Query: 4265 PKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADG 4324
C ++ GY N S Q + +PG +G C+ C+ G+ D
Sbjct: 1244 RHC-ERCAPGYYGNPSQGQPCQRDSQ----VPGPIG-------CN--CDPQGSVSSQCDA 1289
Query: 4325 SRQCRCTAYFEGSRC 4339
+ QC+C A EG C
Sbjct: 1290 AGQCQCKAQVEGLTC 1304
Score = 49.3 bits (116), Expect = 9e-05
Identities = 45/194 (23%), Positives = 61/194 (31%), Gaps = 69/194 (35%)
Query: 3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE-------------------PPTAHTTHC 3741
F C + C+ + +CD +C D +DE +CE PP TT
Sbjct: 204 FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIM 263
Query: 3742 KDK---------------------KEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP 3780
+ +E CRN C+ C+ +DC DGSDE DC P
Sbjct: 264 RQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP 323
Query: 3781 KLTSCATNASICG---------------------DEARCVRTEKAAYCA-----CRSGFH 3814
C N CG DEA C C C S
Sbjct: 324 ---PCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNM 380
Query: 3815 TVPGQPGCQDINEC 3828
+P C + ++C
Sbjct: 381 CIPASFHCDEESDC 394
Score = 48.1 bits (113), Expect = 2e-04
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELD----QCWEHCRNGGTCAASPSGMPTCRCP 4259
C +G +C + +C C+ + GD CE + Q E C +GGTC + C C
Sbjct: 4113 CQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGT-----RCLCL 4167
Query: 4260 TGFTGPKCTQ 4269
GF+GP+C Q
Sbjct: 4168 PGFSGPRCQQ 4177
Score = 47.8 bits (112), Expect = 3e-04
Identities = 28/71 (39%), Positives = 34/71 (47%), Gaps = 7/71 (9%)
Query: 4240 CRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVC----AGYCANNSTCTVNQ--GNQPQCR 4293
C+NGG C S S C CP GFTG +C C ++TC VN+ G CR
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATC-VNRPDGRGYTCR 3911
Query: 4294 CLPGFLGDRCQ 4304
C G G RC+
Sbjct: 3912 CHLGRSGLRCE 3922
Score = 47.4 bits (111), Expect = 3e-04
Identities = 54/205 (26%), Positives = 72/205 (35%), Gaps = 40/205 (19%)
Query: 4219 KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTC-RCPTGFTGPKCTQQ--VCAGY 4275
+C C P Y G C + C G T S + TC RC C + C G
Sbjct: 1125 QCSCPPGYRGPSC------QDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQG- 1177
Query: 4276 CANNSTCTVNQGNQPQC-RCLPGFLGDR-------CQYRQCSG---YCENFGTCQMAADG 4324
C +++ P+C +C PG+ GD CQ C G + TC + DG
Sbjct: 1178 CQHHT-------EGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDG 1230
Query: 4325 SRQC-RCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSN 4383
C C+ G CE RC G N G C P + C +C
Sbjct: 1231 HPTCDACSPGHSGRHCE-----RCAPG-YYGNPSQGQ---PCQRDSQVPGPIGC--NCDP 1279
Query: 4384 GGSCTMNSKMMPECQCPPHMTGPRC 4408
GS + +CQC + G C
Sbjct: 1280 QGSVSSQCDAAGQCQCKAQVEGLTC 1304
Score = 46.6 bits (109), Expect = 6e-04
Identities = 26/73 (35%), Positives = 32/73 (43%), Gaps = 5/73 (6%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCW----EHCRNGGTCAASPSGMP-TCRC 4258
C NGG C + C C +TG +CE Q E C TC P G TCRC
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4259 PTGFTGPKCTQQV 4271
G +G +C + V
Sbjct: 3913 HLGRSGLRCEEGV 3925
Score = 45.4 bits (106), Expect = 0.001
Identities = 30/93 (32%), Positives = 38/93 (40%), Gaps = 13/93 (13%)
Query: 4226 YTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQV----CAGYCANNST 4281
Y CE + C++G TC + C C GF G C + C + T
Sbjct: 4103 YDSSPCER----QPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGT 4158
Query: 4282 CTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCEN 4314
C QG + C CLPGF G RCQ G E+
Sbjct: 4159 C---QGTR--CLCLPGFSGPRCQQGSGHGIAES 4186
Score = 44.7 bits (104), Expect = 0.002
Identities = 26/69 (37%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 4312 CENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGAC-----VVNKQSG-DVTCNC 4365
C+N G C + S C C A F GSRCE ++ C AC VN+ G TC C
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4366 TDGRVAPSC 4374
GR C
Sbjct: 3913 HLGRSGLRC 3921
Score = 42.7 bits (99), Expect = 0.008
Identities = 58/208 (27%), Positives = 75/208 (36%), Gaps = 48/208 (23%)
Query: 4219 KCRCQPRYTGDKCELDQCWEHCRN--GGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYC 4276
+CRC Y+G CE C H GG + SG C C G + G+C
Sbjct: 730 ECRCPIGYSGLSCE--SCDAHFTRVPGGPYLGTCSG---CNC----NGHASSCDPVYGHC 780
Query: 4277 ANNSTCTVNQGNQPQC-RCLPGFLGDR------------CQYRQCSGYCENFGTCQMAAD 4323
N C N PQC +C GF GD C Y S + TC + D
Sbjct: 781 LN---CQHNT-EGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSD--TCFLDTD 834
Query: 4324 GSRQC-RCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCS 4382
G C C + G RCE C+ EG + Q G G+ P V C
Sbjct: 835 GQATCDACAPGYTGRRCE--SCAPGYEGNPI---QPG--------GKCRPVNQEIV-RCD 880
Query: 4383 NGGSCTMNSKMMPECQCPPHMTGPRCEE 4410
GS + + C+C ++ G C E
Sbjct: 881 ERGSMGTSGE---ACRCKNNVVGRLCNE 905
Score = 39.3 bits (90), Expect = 0.090
Identities = 23/70 (32%), Positives = 28/70 (40%), Gaps = 5/70 (7%)
Query: 4276 CANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC----SGYCENFGTCQMAADG-SRQCRC 4330
C N C ++ + C C GF G RC++ Q C TC DG CRC
Sbjct: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
Query: 4331 TAYFEGSRCE 4340
G RCE
Sbjct: 3913 HLGRSGLRCE 3922
Score = 37.4 bits (85), Expect = 0.34
Identities = 42/149 (28%), Positives = 51/149 (34%), Gaps = 21/149 (14%)
Query: 4169 CTCPNGK-RLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYT 4227
C CP G L C P T G C L NG S + +CQ
Sbjct: 1530 CRCPPGYIGLSCQDCAP--GYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAA 1587
Query: 4228 GDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPK-CTQQVCAGYCANNSTCTVNQ 4286
G+ CEL + G A +P C CP T P+ + C A CT
Sbjct: 1588 GEFCELCAPGYY---GDATAGTPEDCQPCACP--LTNPENMFSRTCESLGAGGYRCTA-- 1640
Query: 4287 GNQPQCRCLPGFLGDRCQYRQCS-GYCEN 4314
C PG+ G C+ QC GY N
Sbjct: 1641 -------CEPGYTGQYCE--QCGPGYVGN 1660
Score = 37.0 bits (84), Expect = 0.45
Identities = 38/155 (24%), Positives = 53/155 (34%), Gaps = 45/155 (29%)
Query: 4291 QCRCLPGFLGDRCQYRQCS-GYCEN-----FGTCQMAADGSRQCRCTAYFEGSRCEVNKC 4344
+CRC PG++G CQ C+ GY G C++ C C + + E C
Sbjct: 1529 ECRCPPGYIGLSCQ--DCAPGYTRTGSGLYLGHCEL-------CECNGHSDLCHPETGAC 1579
Query: 4345 SRCLEGAC------VVNKQSGDVTCNCTDGRVAPSC----------LTCVGHCSNGGSCT 4388
S+C A GD T + +C TC + G CT
Sbjct: 1580 SQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCT 1639
Query: 4389 MNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIAS 4423
C P TG CE Q PG++ +
Sbjct: 1640 ---------ACEPGYTGQYCE-----QCGPGYVGN 1660
Score = 37.0 bits (84), Expect = 0.45
Identities = 20/69 (28%), Positives = 26/69 (37%)
Query: 4312 CENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVA 4371
C++ TC A + QC C F+G CE + L C+ C C G
Sbjct: 4113 CQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSG 4172
Query: 4372 PSCLTCVGH 4380
P C GH
Sbjct: 4173 PRCQQGSGH 4181
Score = 35.4 bits (80), Expect = 1.3
Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 23/90 (25%)
Query: 4148 TNPCDRKKCEWLCLLSPSGPV---CTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQ- 4203
++PC+R+ C+ P+G C C +G + D C +P C L+
Sbjct: 4105 SSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGD--LCEHEENP-----------CQLRE 4151
Query: 4204 -CFNGGSCFLNARRQPKCRCQPRYTGDKCE 4232
C +GG+C + +C C P ++G +C+
Sbjct: 4152 PCLHGGTC-----QGTRCLCLPGFSGPRCQ 4176
Score = 34.7 bits (78), Expect = 2.2
Identities = 38/136 (27%), Positives = 51/136 (37%), Gaps = 30/136 (22%)
Query: 4291 QCRCLPGFLGDRCQYRQC-SGYCEN-----FGTCQMAADGSRQCRCTAYFEGSRCEVNKC 4344
QC C PG+ G CQ C +GY GTC+ +C C + E E C
Sbjct: 1125 QCSCPPGYRGPSCQ--DCDTGYTRTPSGLYLGTCE-------RCSCHGHSEACEPETGAC 1175
Query: 4345 SRC---LEGACVVNKQS---GDVTCNC-TDGRVAPSCLTCVGHCSNG---GSCTMNSKMM 4394
C EG Q GD D ++ P C G + G +C +++
Sbjct: 1176 QGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCP----CYGDPAAGQAAHTCFLDTDGH 1231
Query: 4395 PECQ-CPPHMTGPRCE 4409
P C C P +G CE
Sbjct: 1232 PTCDACSPGHSGRHCE 1247
Score = 34.7 bits (78), Expect = 2.2
Identities = 16/37 (43%), Positives = 17/37 (45%), Gaps = 1/37 (2%)
Query: 4374 CLTCVGH-CSNGGSCTMNSKMMPECQCPPHMTGPRCE 4409
C TC C NGG C + C CP TG RCE
Sbjct: 3845 CPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCE 3881
Score = 33.5 bits (75), Expect = 5.0
Identities = 38/139 (27%), Positives = 46/139 (33%), Gaps = 33/139 (23%)
Query: 4219 KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCR-CPTGFTGPKCTQQVCAGYCA 4277
+CRC P Y G C + C G T S + C C C + G C
Sbjct: 1529 ECRCPPGYIGLSC------QDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPE--TGAC- 1579
Query: 4278 NNSTCTVNQGNQPQCRCLPGFLGDR-------CQYRQC---------SGYCENFGTCQMA 4321
S C N + C PG+ GD CQ C S CE+ G
Sbjct: 1580 --SQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLG----- 1632
Query: 4322 ADGSRQCRCTAYFEGSRCE 4340
A G R C + G CE
Sbjct: 1633 AGGYRCTACEPGYTGQYCE 1651
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 127 bits (318), Expect = 3e-28
Identities = 97/308 (31%), Positives = 133/308 (43%), Gaps = 45/308 (14%)
Query: 4139 YHQHKQPEVTNPCDRKKCE--WLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPR 4196
Y QH+ +PC++ +C+ C+ TC C S + P R
Sbjct: 61 YCQHR-----DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY--STSHPCFVSR 113
Query: 4197 PGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCE-LDQCWEH-CRNGGTCAASPSGMP 4254
P C NGG+C + +R +C CQ +TG +C+ D C H C NG TC +
Sbjct: 114 P------CLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQF- 166
Query: 4255 TCRCPTGFTGPKCTQQV----CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQC 4308
+C+C TGFTG KC V G+C + TC +N QC+C GF G C Y C
Sbjct: 167 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCPQGFTGQYCDSLYVPC 225
Query: 4309 S-GYCENFGTCQMAADGSRQCRCTAYFEGSRCE--VNKC--SRCLE-GACVVNKQSGDVT 4362
+ C N GTC+ D + +C C FEGS CE ++ C RC G CV + +
Sbjct: 226 APSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCR 285
Query: 4363 CN-------CTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHV--- 4412
C CT+ CL C NGG+C N C C +G C E++
Sbjct: 286 CPPQWTGQFCTED--VDECLLQPNACQNGGTCA-NRNGGYGCVCVNGWSGDDCSENIDDC 342
Query: 4413 -FSQQQPG 4419
F+ PG
Sbjct: 343 AFASCTPG 350
Score = 119 bits (299), Expect = 5e-26
Identities = 89/269 (33%), Positives = 116/269 (43%), Gaps = 64/269 (23%)
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCE-LDQCWEH-CRNGGTCAASPS-GMPTCRCPT 4260
C N G C C+C + G+ C+ D C ++ C+NGGTC A G TCRC +
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94
Query: 4261 GFTGP------------------------------KCTQQV------------CAGY-CA 4277
GFTG +CT QV C + CA
Sbjct: 95 GFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCA 154
Query: 4278 NNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQCS--GYCENFGTCQMAADGSRQCRCTAY 4333
N STCT NQ C+CL GF G +C+ +C G+C++ GTC + GS QC+C
Sbjct: 155 NGSTCT-TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCPQG 212
Query: 4334 FEGSRCEVNKCSRCLEGACV---VNKQSGDVT--CNCTDGRVAPSCL----TCVGH-CSN 4383
F G C+ + C CV +Q+GD T CNC G +C C H C N
Sbjct: 213 FTGQYCD-SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQN 271
Query: 4384 GGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
GG C ++ C+CPP TG C E V
Sbjct: 272 GGVC-VDGVNTYNCRCPPQWTGQFCTEDV 299
Score = 114 bits (286), Expect = 2e-24
Identities = 94/289 (32%), Positives = 129/289 (44%), Gaps = 34/289 (11%)
Query: 4147 VTNPCDRKKCE--WLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC-NLQ 4203
+ N C R C+ C+ + C CP+G G VP+ + A R G
Sbjct: 1063 LVNLCSRSPCKNKGTCVQKKAESQCLCPSGWA---GAYCDVPNVSCDIAASRRGVLVEHL 1119
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCE--LDQCWEH-CRNGGTCAASPSGMPTCRCPT 4260
C + G C +NA C+C YTG CE LD+C + C++G TC+ G C C
Sbjct: 1120 CQHSGVC-INAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGY-RCECVP 1177
Query: 4261 GFTGPKCTQQV--CAGY-CANNSTCTVNQGNQPQCRCLPGFLGDRCQYR--QCSG--YCE 4313
G+ G C +V C C N TC ++ N +C C PG G C+ C+ +C
Sbjct: 1178 GYQGVNCEYEVDECQNQPCQNGGTC-IDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCL 1236
Query: 4314 NFGTCQMAADGSRQCRCTAYFEGSRCE--VNKC--SRCL-EGACVVNKQSGDVTCNCTDG 4368
N G C M G CRC F G RCE +N+C + C EG+ + + D C C
Sbjct: 1237 NGGQC-MDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSA 1295
Query: 4369 RVAPSCLTCVGHCS-----NGGSCTMNSKMMPE---CQCPPHMTGPRCE 4409
C T V C NGG+C + S M P+ C+CPP +G RC+
Sbjct: 1296 FTGRHCETFVDVCPQMPCLNGGTCAVASNM-PDGFICRCPPGFSGARCQ 1343
Score = 107 bits (266), Expect = 4e-22
Identities = 89/282 (31%), Positives = 119/282 (42%), Gaps = 41/282 (14%)
Query: 4148 TNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP-SPTPPPDAPRPGTCNLQCFN 4206
+NPC + C SG C C N V P SP P C N
Sbjct: 801 SNPCLN---QGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNP-------------CEN 844
Query: 4207 GGSCFLNARRQP-KCRCQPRYTGDKC--ELDQCWEH-CRNGGTCAASPSGMPTCRCPTGF 4262
C + + C C P + G +C ++D+C C N G C + G C CP GF
Sbjct: 845 AAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCH-NTQGSYMCECPPGF 903
Query: 4263 TGPKCTQQV---CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQC-SGYCENFG 4316
+G C + + A C N +C ++ N C CLPGF GD+CQ +C S C+N G
Sbjct: 904 SGMDCEEDIDDCLANPCQNGGSC-MDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGG 962
Query: 4317 TCQMAADGSRQCRCTAYFEGSRCE--VNKC--SRCLEGACVVNKQSGDVTCNCTDGRVAP 4372
TC + S C+C A F+G CE +N+C S C G V+ +C C G
Sbjct: 963 TCSDYVN-SYTCKCQAGFDGVHCENNINECTESSCFNGGTCVD-GINSFSCLCPVGFTGS 1020
Query: 4373 SCL----TCVGH-CSNGGSCTMNSKMMPECQCPPHMTGPRCE 4409
CL C H C N G+C ++ C CP TG C+
Sbjct: 1021 FCLHEINECSSHPCLNEGTC-VDGLGTYRCSCPLGYTGKNCQ 1061
Score = 103 bits (258), Expect = 3e-21
Identities = 83/277 (29%), Positives = 108/277 (38%), Gaps = 31/277 (11%)
Query: 4160 CLLSPSGPVCTCPNGKRLDNGT----CVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNAR 4215
CLL P+ C NG N CV V + + C GS ++
Sbjct: 302 CLLQPNA----CQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRV 357
Query: 4216 RQPKCRCQPRYTGDKCELDQCW--EHCRNGGTCAASP-SGMPTCRCPTGFTGPKCTQQVC 4272
C C G C LD C G C +P +G C CP G+ G CT+ V
Sbjct: 358 ASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVD 417
Query: 4273 AGYCANNSTC-----TVNQGNQPQCRCLPGFLGDRCQ--YRQC-SGYCENFGTCQMAADG 4324
AN++ C VN C CL G+ G RC+ +C S C+N TC + G
Sbjct: 418 ECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATC-LDKIG 476
Query: 4325 SRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGD----VTCNCTDGRVAPSCLTCVGH 4380
C C F+G CE+ + + C CV N Q D C C G P C +
Sbjct: 477 GFTCLCMPGFKGVHCEL-EINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD 535
Query: 4381 CS-----NGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
CS NG C ++ ECQC TG CEE++
Sbjct: 536 CSSTPCLNGAKC-IDHPNGYECQCATGFTGVLCEENI 571
Score = 100 bits (250), Expect = 3e-20
Identities = 62/191 (32%), Positives = 79/191 (41%), Gaps = 21/191 (10%)
Query: 4237 WEHCRNGGTCAASPSGMPTCRCPTGFTGPKCT-QQVC-AGYCANNSTCTVN-QGNQPQCR 4293
+E C N G C +G C+CP GF G C + C C N TC + CR
Sbjct: 32 YEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCR 91
Query: 4294 CLPGFLGDRCQYRQ-----CSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCL 4348
C GF G+ CQY S C N GTC M + + +C C F G C+ CL
Sbjct: 92 CASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT--DACL 149
Query: 4349 EGAC----VVNKQSGDVTCNCTDGRVAPSCLTCV------GHCSNGGSCTMNSKMMPECQ 4398
C + +C C G C T V GHC +GG+C +N +CQ
Sbjct: 150 SHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQ 208
Query: 4399 CPPHMTGPRCE 4409
CP TG C+
Sbjct: 209 CPQGFTGQYCD 219
Score = 96.3 bits (238), Expect = 6e-19
Identities = 83/275 (30%), Positives = 111/275 (40%), Gaps = 71/275 (25%)
Query: 4204 CFNGGSC--FLNARRQPKCRCQPRYTGDKCE--LDQCWEH-CRNGGTCAASPSGMPTCRC 4258
C +G +C F+ R C C P Y G CE +D+C C+NGGTC + C C
Sbjct: 1158 CQHGATCSDFIGGYR---CECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFK-CSC 1213
Query: 4259 PTGFTGPKCTQQV--CAG--YCANNSTCTVNQGNQPQCRCLPGFLGDRCQY--------- 4305
P G G C + + CA +C N C G CRCLPGF G+RC+
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGY-SCRCLPGFAGERCEGDINECLSNP 1272
Query: 4306 --------------------------RQCSGY--------CENFGTCQMAAD--GSRQCR 4329
R C + C N GTC +A++ CR
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICR 1332
Query: 4330 CTAYFEGSRCEVNKCS--RCLEGACVVNKQSGDVTCNCTDGRVAPS-CLTCVGHCSNGGS 4386
C F G+RC+ + C +C +G V+ SG C C R S C + C +GGS
Sbjct: 1333 CPPGFSGARCQ-SSCGQVKCRKGEQCVHTASGP-RCFCPSPRDCESGCAS--SPCQHGGS 1388
Query: 4387 CTMNSKMMP---ECQCPPHMTGPRCEEHVFSQQQP 4418
C + + P CQC P +G RCE + P
Sbjct: 1389 C--HPQRQPPYYSCQCAPPFSGSRCELYTAPPSTP 1421
Score = 94.7 bits (234), Expect = 2e-18
Identities = 88/342 (25%), Positives = 134/342 (39%), Gaps = 84/342 (24%)
Query: 4149 NPCDRKKCE-----WLCLLSPS--GPVCT-----CPNGKRLDNGTCVPVPSPTPPPDAPR 4196
+PC +C+ + C+ +P G +C+ C + L++G C+ + + +
Sbjct: 577 DPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNC--Q 634
Query: 4197 PGTCNLQC-FNGGSCFLN---------ARRQPKCRCQPRYTGDKC--ELDQCWEH-CRNG 4243
PGT + C N C N + C C P +TG +C ++D+C + CR G
Sbjct: 635 PGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKG 694
Query: 4244 GTCAASPSGMPTCRCPTGFTGPKCTQQV--CAGYCANNSTCTVNQGNQPQCRCLPGFLGD 4301
TC +G C CP G P C QV C + CT +C C G++G
Sbjct: 695 ATCINGVNGF-RCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGY-KCLCDAGWVGI 752
Query: 4302 RCQY--RQC-SGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVN--KCSR--CLEGACVV 4354
C+ +C S C+N GTC +G R C C F+G C+VN +C+ CL
Sbjct: 753 NCEVDKNECLSNPCQNGGTCDNLVNGYR-CTCKKGFKGYNCQVNIDECASNPCLNQGTCF 811
Query: 4355 NKQSGDVTCNCTDGRVAPSCLTCVGHCS---------------------------NGGSC 4387
+ SG TC+C +C T + CS G C
Sbjct: 812 DDISG-YTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRC 870
Query: 4388 TM-----------------NSKMMPECQCPPHMTGPRCEEHV 4412
T+ N++ C+CPP +G CEE +
Sbjct: 871 TIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDI 912
Score = 81.3 bits (199), Expect = 2e-14
Identities = 59/190 (31%), Positives = 74/190 (38%), Gaps = 31/190 (16%)
Query: 4246 CAASPSGMPTCRCPTGFTGPKCTQQVCAGY--CANNSTCTVNQGNQPQCRCLPGFLGDRC 4303
C A+P+ CR GY C N C C+C GFLG+ C
Sbjct: 18 CCAAPAHALQCR---------------DGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYC 62
Query: 4304 QYRQ-CS-GYCENFGTC-QMAADGSRQCRCTAYFEGSRCEVNKC-----SR-CLEGACVV 4354
Q+R C C+N GTC A G CRC + F G C+ + SR CL G
Sbjct: 63 QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCH 122
Query: 4355 NKQSGDVTCNCTDGRVAPSCL---TCVGH-CSNGGSCTMNSKMMPECQCPPHMTGPRCEE 4410
C C G C C+ H C+NG +CT + C+C TG +CE
Sbjct: 123 MLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQF-SCKCLTGFTGQKCET 181
Query: 4411 HVFSQQQPGH 4420
V PGH
Sbjct: 182 DVNECDIPGH 191
Score = 77.8 bits (190), Expect = 2e-13
Identities = 159/658 (24%), Positives = 213/658 (32%), Gaps = 195/658 (29%)
Query: 3288 DVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCI 3347
D+P H C+ + G C NL G ++C CP F G+ C S C
Sbjct: 187 DIPGH-CQ-HGGTCLNL-----PGSYQCQCPQGF----TGQYCDSLYVP---------CA 226
Query: 3348 PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQ---CSTGICTNPAFICDGDNDCQDNSD 3404
P C C D +C C PG F+ C I P C C D +
Sbjct: 227 PS--PCVNGGTCRQTGDFTFEC---NCLPG-FEGSTCERNIDDCPNHRCQNGGVCVDGVN 280
Query: 3405 EANC-------------DIHVCLPSQFKCTNTNRCI--PGIFRC---NG--QDNCGDGED 3444
NC D+ CL C N C G + C NG D+C + D
Sbjct: 281 TYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENID 340
Query: 3445 ERDCPEVTCAPNQFQCSITKRCIPRV-------------WVCDRDNDCVDG--------S 3483
DC +C P CI RV +C D+ C+
Sbjct: 341 --DCAFASCTPG-------STCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCD 391
Query: 3484 DEPAN----CT--------QMTCGVDEFRCKDSGRCIPARWKCDGED-----DCGDGSDE 3526
P N CT T VDE +S C A KC D +C G
Sbjct: 392 TNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHA-GKCVNTDGAFHCECLKGYAG 450
Query: 3527 PKEECDERTCEPYQFRCKNNR------------CVPG--RWQCDYD-NDCGDNSDEESCT 3571
P+ E D C + C+N+ C+PG C+ + N+C N
Sbjct: 451 PRCEMDINEC--HSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSN------- 501
Query: 3572 PRPCSESEFSCANGRCI--AGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLR 3629
PC NG+C+ R++C C G P C +D C S C+
Sbjct: 502 --PCVN------NGQCVDKVNRFQC----LCPPGF----TGPVCQIDIDDCSSTPCL--- 542
Query: 3630 WRCDADADCMDGSD--EEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP 3687
A C+D + E C TG LC+ CD D C ++
Sbjct: 543 ----NGAKCIDHPNGYECQCATGF----------TGVLCEENIDNCD-PDPCHHGQCQDG 587
Query: 3688 EECARFVCPPN-------------RPFRCKNDRVCLWI--GRQCDGTDNCGDGTDEEDCE 3732
+ +C P C ND C+ + G QC NC GT +CE
Sbjct: 588 IDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQC----NCQPGTSGVNCE 643
Query: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792
+ D C + C+ R + C G + C+ID + CA+N C
Sbjct: 644 ------INFDDCASNPCIHGICMDGINRYSCV--CSPGFTGQRCNID--IDECASNP--C 691
Query: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGC-QDINECLRFGTCSQLCNNTKGGHLCSC 3849
A C+ C C G P P C +NECL C G+ C C
Sbjct: 692 RKGATCINGVNGFRCICPEG----PHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLC 745
Score = 76.6 bits (187), Expect = 5e-13
Identities = 127/532 (23%), Positives = 179/532 (33%), Gaps = 133/532 (25%)
Query: 2515 LTCRAVNSSCRAQDEFE-CAN-GECINFSLTCDGVPHCKDKSDEKPSYCNSRR-CKKTFR 2571
L C A + + +D +E C N G C+ + +G +CK YC R C+K
Sbjct: 17 LCCAAPAHALQCRDGYEPCVNEGMCVTYH---NGTGYCKCPEGFLGEYCQHRDPCEKN-- 71
Query: 2572 QCSNG-RCVSNMLWCNGADDCGDGSDEIPCNKTA---CGVGEFRCRDGTCIGNSSRCNQF 2627
+C NG CV+ + C G C + C V GTC SR
Sbjct: 72 RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC-HMLSRDTYE 130
Query: 2628 VDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLC--YAPSWVCD-----GANDCG 2680
C+ C TD L PC S C A + C C
Sbjct: 131 CTCQVGFTGKECQWTDAC----------LSHPCANGSTCTTVANQFSCKCLTGFTGQKCE 180
Query: 2681 DYSDERDCPGVKRPRCPLNYFACPSGRCI--PMSWTCDKEDDCEHGEDETHCNKFCSEAQ 2738
+E D PG C G C+ P S+ C C G ++C
Sbjct: 181 TDVNECDIPG----HCQ------HGGTCLNLPGSYQCQ----CPQG----FTGQYCDSLY 222
Query: 2739 FECQNHRCISKQWLCDGSDDCGDGSDEAAHC------EGKTCGPSSFSCPGTHVCVPERW 2792
C C++ C D C EG TC + CP
Sbjct: 223 VPCAPSPCVN-------GGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR------- 268
Query: 2793 LCDGDKDCADGADESIAAGCLYNSTCDDR---EFMCQN-RQCIPKHFVCDHDRDCADGSD 2848
C C DG + YN C + +F ++ +C+ + C + CA+ +
Sbjct: 269 -CQNGGVCVDGVNT-------YNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRN- 319
Query: 2849 ESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE---APKNPHCTSQEHKCN 2905
G C NG W D DC + D+ A P T +
Sbjct: 320 ----------GGYGCVCVNG-------WSGD---DCSENIDDCAFASCTPGSTCIDRV-- 357
Query: 2906 ASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKC 2965
AS +C G+ LLC+ D C + CH G D L + C
Sbjct: 358 ASFSCMCPEGKA---GLLCHLDDACISNP----CH---------KGALCDTNPLNGQYIC 401
Query: 2966 RCRPGFRLKDDGRTCA-DVDECS--TTFPCSQ--RCINTHGSYKCLCVEGYA 3012
C G++ G C DVDEC+ + PC +C+NT G++ C C++GYA
Sbjct: 402 TCPQGYK----GADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA 449
Score = 75.5 bits (184), Expect = 1e-12
Identities = 73/270 (27%), Positives = 105/270 (38%), Gaps = 37/270 (13%)
Query: 4160 CLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPK 4219
C+ P+G C C G G PD G QC +G +
Sbjct: 547 CIDHPNGYECQCATGF---TGVLCEENIDNCDPDPCHHG----QCQDGIDSYT------- 592
Query: 4220 CRCQPRYTGDKC--ELDQCWEH-CRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYC 4276
C C P Y G C ++D+C+ C N G C +G C C G +G C ++ C
Sbjct: 593 CICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ-CNCQPGTSGVNC--EINFDDC 649
Query: 4277 ANNSTC---TVNQGNQPQCRCLPGFLGDRC--QYRQC-SGYCENFGTCQMAADGSRQCRC 4330
A+N ++ N+ C C PGF G RC +C S C TC +G R C C
Sbjct: 650 ASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFR-CIC 708
Query: 4331 TAYFEGSRCEVNKCSRCLEGACVVNKQSGDVT---CNCTDGRVAPSCLT----CVGH-CS 4382
C ++ + CL C+ +G ++ C C G V +C C+ + C
Sbjct: 709 PEGPHHPSC-YSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQ 767
Query: 4383 NGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
NGG+C N C C G C+ ++
Sbjct: 768 NGGTCD-NLVNGYRCTCKKGFKGYNCQVNI 796
Score = 73.2 bits (178), Expect = 6e-12
Identities = 132/609 (21%), Positives = 197/609 (32%), Gaps = 133/609 (21%)
Query: 2473 DTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC 2532
D N C +PC+ N G C +L C+C+ G +C+ + EC
Sbjct: 757 DKNECLSNPCQ-NGGTCDNLV-----NGYRCTCKKG----------FKGYNCQVNID-EC 799
Query: 2533 ANGECINFSLTCDGVPHCKDKSDEKPSYC----NSRRCKKTFRQCSNGRCVSNMLWCNGA 2588
A+ C+N C D +C + C+ CS C N C +
Sbjct: 800 ASNPCLNQGT-------CFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPC-ENAAVCKES 851
Query: 2589 DD-------CGDGSDEIPC--------NKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDA 2633
+ C G C +K G G+ + +DCE+
Sbjct: 852 PNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEED 911
Query: 2634 SDEMNCSATDC----------SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYS 2683
D+ C A C +++ L + G C+ T + S C C DY
Sbjct: 912 IDD--CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ-TDMNECLSEPCKNGGTCSDYV 968
Query: 2684 DERDCP---GVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-------NKF 2733
+ C G C N C C C G + C F
Sbjct: 969 NSYTCKCQAGFDGVHCENNINECTESSCF-------NGGTCVDGINSFSCLCPVGFTGSF 1021
Query: 2734 CSEAQFECQNHRCISKQWLCDGSD----DCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVP 2789
C EC +H C+++ DG C G +C+ S C CV
Sbjct: 1022 CLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYT-GKNCQTLVNLCSRSPCKNKGTCVQ 1080
Query: 2790 ERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDE 2849
++ + C + + A + N +CD + +R+ + +C H C + +
Sbjct: 1081 KK----AESQCLCPSGWAGAYCDVPNVSCD----IAASRRGVLVEHLCQHSGVCINAGN- 1131
Query: 2850 SPECEYPT------CGPSEFRCANGRC---------LSSRQWEC----DGENDCHDQSDE 2890
+ C+ P C CA+ C + + EC G N C + DE
Sbjct: 1132 THYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVN-CEYEVDE 1190
Query: 2891 APKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLS 2950
P C + + + F CS L DDC RG H CL+
Sbjct: 1191 CQNQP-CQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCA-----RGPH---CLN---- 1237
Query: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC-ADVDECSTTFPCSQR----CINTHGSYKC 3005
C D G+ CRC PGF G C D++EC + PCS CI Y C
Sbjct: 1238 --GGQCMDRIGGYSCRCLPGFA----GERCEGDINECLSN-PCSSEGSLDCIQLTNDYLC 1290
Query: 3006 LCVEGYAPR 3014
+C + R
Sbjct: 1291 VCRSAFTGR 1299
Score = 67.4 bits (163), Expect = 3e-10
Identities = 157/706 (22%), Positives = 229/706 (32%), Gaps = 205/706 (29%)
Query: 3288 DVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC---VSNCTASQFVCKND 3344
D PNH C+ N G C + + C CP + G+ C V C C+N
Sbjct: 263 DCPNHRCQ-NGGVC-----VDGVNTYNCRCPPQW----TGQFCTEDVDECLLQPNACQNG 312
Query: 3345 K------------CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQ--------FQC--- 3381
C+ W + DDC ++ D DC C PG F C
Sbjct: 313 GTCANRNGGYGCVCVNGW----SGDDCSENID---DCAFASCTPGSTCIDRVASFSCMCP 365
Query: 3382 ----------STGICTNPAF---ICDGDN-------DCQDNSDEANC--DIHVC-LPSQF 3418
+NP +CD + C A+C D+ C + +
Sbjct: 366 EGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSN 425
Query: 3419 KCTNTNRCI--PGIFRCNGQDNCGDGEDERDCPEVTCAP--NQFQC-----SITKRCIP- 3468
C + +C+ G F C E D E P N C T C+P
Sbjct: 426 PCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPG 485
Query: 3469 -------------RVWVCDRDNDCVDGSDE-----PANCTQMTCGVD-----EFRCKDSG 3505
+ C + CVD + P T C +D C +
Sbjct: 486 FKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGA 545
Query: 3506 RCI--PARWKCDGEDDCGDG-----SDEPKEECDERTCEPYQFRCKNNR------CVPGR 3552
+CI P ++C C G +E + CD C Q C++ C PG
Sbjct: 546 KCIDHPNGYECQ----CATGFTGVLCEENIDNCDPDPCHHGQ--CQDGIDSYTCICNPGY 599
Query: 3553 WQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCI--AGRWKCDGDHDCADGSDEKDCT 3610
C D DE C PC +GRCI ++C+ C G+ +C
Sbjct: 600 MGAI----CSDQIDE--CYSSPCLN------DGRCIDLVNGYQCN----CQPGTSGVNCE 643
Query: 3611 PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC----GTGVRTCPLDEFQCNNTLC 3666
D C S CI CMDG + +C G + C +D +C + C
Sbjct: 644 INFD----DCASNPCI--------HGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPC 691
Query: 3667 KPLAWKCDGEDDCGDNSDENPE---------ECARFVCPPNRPFRCKNDRVCL----WIG 3713
+ A +G + E P EC C + CL W+G
Sbjct: 692 RKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVG 751
Query: 3714 RQCDGTDN------CGDGTDEEDCEPPTAHTTHCKDKKEFL----------CRNQRCLSS 3757
C+ N C +G ++ + C KK F C + CL+
Sbjct: 752 INCEVDKNECLSNPCQNGGTCDNL----VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQ 807
Query: 3758 SLRCNMFDD-------CGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTE--KAAYCA 3808
FDD C ++C L C+ N C + A C + ++ C
Sbjct: 808 G---TCFDDISGYTCHCVLPYTGKNCQT--VLAPCSPNP--CENAAVCKESPNFESYTCL 860
Query: 3809 CRSGFHTVPGQPGCQDINECLRFGTCSQ-LCNNTKGGHLCSCARNF 3853
C G+ GQ DI+EC+ + LC+NT+G ++C C F
Sbjct: 861 CAPGWQ---GQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGF 903
Score = 64.3 bits (155), Expect = 3e-09
Identities = 112/484 (23%), Positives = 159/484 (32%), Gaps = 90/484 (18%)
Query: 3419 KCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIP--RVWVCDRD 3476
+C N C+ C G DC T P C +++ C+ + RD
Sbjct: 72 RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP----CFVSRPCLNGGTCHMLSRD 127
Query: 3477 N-DCVDGSDEPANCTQMTCGVDEFRCKDSGRC--IPARWKCDGEDDCGDGSDEPKEECDE 3533
+C Q T C + C + ++ C C G K E D
Sbjct: 128 TYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCK----CLTGFTGQKCETDV 183
Query: 3534 RTCEPYQFRCKNNRCV--PGRWQCDYDNDCGDNSDEESCTPR--PCSESEFSCANGRCIA 3589
C+ C+ PG +QC C + C PC+ S C NG
Sbjct: 184 NECDIPGHCQHGGTCLNLPGSYQCQ----CPQGFTGQYCDSLYVPCAPSP--CVNGGTCR 237
Query: 3590 GRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACG- 3648
+ +C G + C D C + RC C+DG + C
Sbjct: 238 QTGDFTFECNCLPGFEGSTCERNID----DCPNH-------RCQNGGVCVDGVNTYNCRC 286
Query: 3649 ----TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDC----------------GDNSDENPE 3688
TG + C D +C L +P A C C GD+ EN +
Sbjct: 287 PPQWTG-QFCTEDVDEC---LLQPNA--CQNGGTCANRNGGYGCVCVNGWSGDDCSENID 340
Query: 3689 ECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFL 3748
+CA C P C I R + C +G C A ++ K
Sbjct: 341 DCAFASCTPGS--------TC--IDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGAL- 389
Query: 3749 CRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCA-TNASICGDEARCVRTEKAAYC 3807
C ++ L C G DC+ D + CA N++ C +CV T+ A +C
Sbjct: 390 -----CDTNPLNGQYICTCPQGYKGADCTED--VDECAMANSNPCEHAGKCVNTDGAFHC 442
Query: 3808 ACRSGFHTVPGQPGCQ-DINECLRFGTCSQ--LCNNTKGGHLCSCARNFMKTHNTCKAEG 3864
C G+ P C+ DINEC C C + GG C C F H C+ E
Sbjct: 443 ECLKGY----AGPRCEMDINEC-HSDPCQNDATCLDKIGGFTCLCMPGFKGVH--CELEI 495
Query: 3865 SEYQ 3868
+E Q
Sbjct: 496 NECQ 499
Score = 60.8 bits (146), Expect = 3e-08
Identities = 159/713 (22%), Positives = 224/713 (31%), Gaps = 210/713 (29%)
Query: 2477 CELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGE 2536
C SPC +N G C+ T + C+C G S+C + +C N
Sbjct: 225 CAPSPC-VNGGTCRQTGDFTFE----CNCLPG----------FEGSTCERNID-DCPNHR 268
Query: 2537 CINFSLTCDGVP--HCKDKSDEKPSYCNSR--RCKKTFRQCSNGRCVSNM------LWCN 2586
C N + DGV +C+ +C C C NG +N + N
Sbjct: 269 CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVN 328
Query: 2587 G--ADDCGDGSDEIPCNKTACGVGE--------FRCR------------DGTCIGNSSRC 2624
G DDC + D+ C +C G F C D CI N
Sbjct: 329 GWSGDDCSENIDD--CAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHK 386
Query: 2625 NQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLC-YAPSWVCDGANDCGDYS 2683
D + + C+ G KG E C A S C+ A C +
Sbjct: 387 GALCDTNPLNGQYICTCPQ-------GYKGA--DCTEDVDECAMANSNPCEHAGKCVNTD 437
Query: 2684 DERDCP---GVKRPRCPLNYFACPSGRCIPMSWTCDKEDD----CEHGEDETHCNKFCSE 2736
C G PRC ++ C S C + DK C G HC +E
Sbjct: 438 GAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINE 497
Query: 2737 AQFE--CQNHRCISK----QWLCDGS----------DDCG-----DGSDEAAHCEGKTC- 2774
Q N +C+ K Q LC DDC +G+ H G C
Sbjct: 498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQ 557
Query: 2775 ---GPSSFSCP-GTHVCVPE---RWLCDGDKD--------------CADGADESIAAGCL 2813
G + C C P+ C D C+D DE ++ CL
Sbjct: 558 CATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCL 617
Query: 2814 YNSTCDD--REFMCQNRQCIPKHFVCDHDRD-----------CADGSDE-----SPECEY 2855
+ C D + C N Q C+ + D C DG + SP
Sbjct: 618 NDGRCIDLVNGYQC-NCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTG 676
Query: 2856 PTCGPSEFRCANGRCLSSRQ-------WEC---DGEN--DCHDQSDEAPKNP----HCTS 2899
C CA+ C + C +G + C+ Q +E NP +CT
Sbjct: 677 QRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTG 736
Query: 2900 --QEHKCNASSQFL---------------CSSG----------RCVAEALL--------- 2923
+KC + ++ C +G RC +
Sbjct: 737 GLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNI 796
Query: 2924 -------CNGQDDCGDSSDERGCHINECLSRK-----LSGCSQD-CEDLKI--------G 2962
C Q C D CH + K L+ CS + CE+ +
Sbjct: 797 DECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFES 856
Query: 2963 FKCRCRPGFRLKDDGRTCA-DVDECSTTFPCSQR--CINTHGSYKCLCVEGYA 3012
+ C C PG++ G+ C D+DEC + PC C NT GSY C C G++
Sbjct: 857 YTCLCAPGWQ----GQRCTIDIDECISK-PCMNHGLCHNTQGSYMCECPPGFS 904
Score = 54.7 bits (130), Expect = 2e-06
Identities = 123/632 (19%), Positives = 198/632 (31%), Gaps = 159/632 (25%)
Query: 2475 NSCELSPCRINNGGCQD-------LCLLTHQGHVNCS----------CRGGRILQDDLTC 2517
+ C +PC +N G C D C+L + G NC C + ++
Sbjct: 797 DECASNPC-LNQGTCFDDISGYTCHCVLPYTGK-NCQTVLAPCSPNPCENAAVCKESPNF 854
Query: 2518 RAVNSSCRAQ--------DEFECANGECINFSL--TCDGVPHCKDKSDEKPSYCNSRRCK 2567
+ C D EC + C+N L G C E P + C+
Sbjct: 855 ESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMC-----ECPPGFSGMDCE 909
Query: 2568 KTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC------NKTACGVGEFRCRDGTCIGNS 2621
+ C ++N C C DG + C C C C N
Sbjct: 910 EDIDDC-----LANP--CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPC-KNG 961
Query: 2622 SRCNQFVD-----CEDASDEMNC--SATDC--SSYFRLG--VKGVLFQPCERTSLC---Y 2667
C+ +V+ C+ D ++C + +C SS F G V G+ C LC +
Sbjct: 962 GTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC----LCPVGF 1017
Query: 2668 APSWVCDGANDCGDYS--DERDCP---GVKRPRCPLNYFA--CPSGRCIPMSWTCDKEDD 2720
S+ N+C + +E C G R CPL Y C + + C +
Sbjct: 1018 TGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGT 1077
Query: 2721 CEHGEDETHC-------NKFCSEAQFECQ---NHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
C + E+ C +C C + R + + LC S C
Sbjct: 1078 CVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVC----------- 1126
Query: 2771 GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQC 2830
+ TH C + L C + DE + C + +TC D
Sbjct: 1127 --------INAGNTHYC--QCPLGYTGSYCEEQLDECASNPCQHGATCSD---------- 1166
Query: 2831 IPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANG-RCLSS-RQWECDGEND----- 2883
F+ + +C G + CEY C NG C+ ++C
Sbjct: 1167 ----FIGGYRCECVPGY-QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLL 1221
Query: 2884 CHDQSDEAPKNPHCTSQEHKCNASSQFLCSS-------------GRCVAEALLCNGQDDC 2930
C + D+ + PHC + + + C C++ G DC
Sbjct: 1222 CEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDC 1281
Query: 2931 GDSSDERGCHINECLSRKL---------------SGCSQDCEDLKIGFKCRCRPGFRLKD 2975
+++ C + + G ++ GF CRC PGF
Sbjct: 1282 IQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGAR 1341
Query: 2976 DGRTCADVDECSTTFPCSQRCINTHGSYKCLC 3007
+C V +C ++C++T +C C
Sbjct: 1342 CQSSCGQV-KCRK----GEQCVHTASGPRCFC 1368
Score = 54.3 bits (129), Expect = 3e-06
Identities = 133/615 (21%), Positives = 193/615 (31%), Gaps = 143/615 (23%)
Query: 3293 PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWK 3352
PC +N+G C N G + C CP F G D + +C A+
Sbjct: 881 PC-MNHGLCHNT-----QGSYMCECPPGFS-GMDCEEDIDDCLANP-------------- 919
Query: 3353 CDTEDDCGDHSDE-----PPDCPEFKCRPGQFQCSTGICTNPAFICDGDND----CQDNS 3403
C C D + P KC+ +C + C N D N CQ
Sbjct: 920 CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGF 979
Query: 3404 DEANCDIHVCLPSQFKCTNTNRCIPGI--FRCNGQDNCGDGEDERDCP----EVTCAPNQ 3457
D +C+ ++ ++ C N C+ GI F C CP C
Sbjct: 980 DGVHCENNINECTESSCFNGGTCVDGINSFSCL-------------CPVGFTGSFCLHEI 1026
Query: 3458 FQCSITKRCIPRVWVCDRDNDCVDG----------SDEPANCTQMTCGVDEFRCKDSGRC 3507
+CS C + CVDG NC + CK+ G C
Sbjct: 1027 NECSSHP--------CLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC 1078
Query: 3508 IPARWKCDGEDDCGDG-----SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCG 3562
+ + K + + C G D P CD + R V C + C
Sbjct: 1079 V--QKKAESQCLCPSGWAGAYCDVPNVSCD---------IAASRRGVLVEHLCQHSGVCI 1127
Query: 3563 DNSDEESC------TPRPCSESEFSCANGRC--------IAGRWKCDGDHDCADGSDEKD 3608
+ + C T C E CA+ C G ++C +C G +
Sbjct: 1128 NAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRC----ECVPGYQGVN 1183
Query: 3609 CTPRCDMDQFQ-CKS-GHCIPL--RWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNT 3664
C D Q Q C++ G CI L ++C C G+ C + C N
Sbjct: 1184 CEYEVDECQNQPCQNGGTCIDLVNHFKC----SCPPGTRGLLCEENIDDCARGPHCLNGG 1239
Query: 3665 LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKND-RVCLWIGRQCDGTDNCG 3723
C D G S P RC+ D CL +G+ +C
Sbjct: 1240 QCM---------DRIGGYSCR--------CLPGFAGERCEGDINECLSNPCSSEGSLDCI 1282
Query: 3724 DGTDEEDCEPPTAHT-THCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKL 3782
T++ C +A T HC+ + +C CL+ C + + DG C P
Sbjct: 1283 QLTNDYLCVCRSAFTGRHCETFVD-VCPQMPCLNGG-TCAVASNMPDGF---ICRCPPGF 1337
Query: 3783 TSCATNASI----CGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLC 3838
+ +S C +CV T C C S + GC + C G+C
Sbjct: 1338 SGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDC---ESGCAS-SPCQHGGSCHP-- 1391
Query: 3839 NNTKGGHLCSCARNF 3853
+ C CA F
Sbjct: 1392 QRQPPYYSCQCAPPF 1406
Score = 53.9 bits (128), Expect = 4e-06
Identities = 133/613 (21%), Positives = 197/613 (32%), Gaps = 167/613 (27%)
Query: 795 YDAQQQQVGTNKCRVNNGGCS--SLCLATPGSRQCACAE---DQVLDA-----------D 838
+ Q+ + N+C + G C CL PGS QC C + Q D+ +
Sbjct: 174 FTGQKCETDVNECDIP-GHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVN 232
Query: 839 GVTCLANPSYVPPPQCQPGEFACANSRCIQE--RWKCDGDNDCLDNSDEAPALCHQHTCP 896
G TC + C PG R I + +C C+D + C
Sbjct: 233 GGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQW-- 290
Query: 897 SDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATC----SARTCPPNQFSCASGRCIPI 951
+ +F E+ + C+ C C N C S C N CA C P
Sbjct: 291 TGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPG 350
Query: 952 S-------------------WTCDLDDDC------------------------------G 962
S C LDD C
Sbjct: 351 STCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGA 410
Query: 963 DRSDESASCAYPTCFPLTQFTCNNGRCININW-------------RCDND-NDCGDN--S 1006
D +++ CA P + G+C+N + RC+ D N+C +
Sbjct: 411 DCTEDVDECAMANSNPCE----HAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQ 466
Query: 1007 DEAGCSHSCSSTQFKCNSGRCIP--EHWTCDGD-NDCGDYSDETHANCTNQATR-----P 1058
++A C F C C+P + C+ + N+C + C ++ R P
Sbjct: 467 NDATCLDKIGG--FTC---LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCP 521
Query: 1059 PG----GCHTDEFQCR----LDGL-CI--PLRWRCDGDT--------DCMDSSDEKSC-- 1097
PG C D C L+G CI P + C T + +D+ D C
Sbjct: 522 PGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHH 581
Query: 1098 -------EGVTHVCDPSVKFG-CKDSA-RCISKAWVCDG---------DNDCEDNSDEEN 1139
+ T +C+P C D C S + DG +C+ + N
Sbjct: 582 GQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVN 641
Query: 1140 CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELC----DQCSLNNGGCSHN 1195
CE S+PC + +C+ D + + C G G+ C D+C+ N C
Sbjct: 642 CEINFDDCASNPCIH--GICM--DGINRYSCVCSPGF-TGQRCNIDIDECASN--PCRKG 694
Query: 1196 CSVAPG-EGIVCSCPLGMELGPDNHTCQIQ-SYCAKHLKCSQKCDQNKFSVKCSCYEGWV 1253
+ G G C CP GP + +C Q + C + C KC C GWV
Sbjct: 695 ATCINGVNGFRCICP----EGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWV 750
Query: 1254 ---LEPDGESCRS 1263
E D C S
Sbjct: 751 GINCEVDKNECLS 763
Score = 52.0 bits (123), Expect = 1e-05
Identities = 53/212 (25%), Positives = 85/212 (40%), Gaps = 60/212 (28%)
Query: 4151 CDRKKCEW--LCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGG 4208
C + KC C+ + SGP C CP+ + ++G C P C +GG
Sbjct: 1346 CGQVKCRKGEQCVHTASGPRCFCPSPRDCESG-CASSP-----------------CQHGG 1387
Query: 4209 SCFLNARRQP---KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGP 4265
SC + +RQP C+C P ++G +CEL +P P C + +
Sbjct: 1388 SC--HPQRQPPYYSCQCAPPFSGSRCEL-------------YTAPPSTPPATCLSQYCAD 1432
Query: 4266 KCTQQVCAGYCANNSTCTVNQGN------QPQCRC---LP--GFLGDRCQYRQCSGYC-- 4312
K VC C N+ C + G+ P C LP ++ ++C + C
Sbjct: 1433 KARDGVCDEAC-NSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLF 1491
Query: 4313 ENFGTCQMAADGSRQCR----CTAYFEGSRCE 4340
+NF CQ S+ C+ C +F+ + C+
Sbjct: 1492 DNF-ECQ---GNSKTCKYDKYCADHFKDNHCD 1519
Score = 47.4 bits (111), Expect = 3e-04
Identities = 111/481 (23%), Positives = 147/481 (30%), Gaps = 163/481 (33%)
Query: 810 NNGGCSSL-----CLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQP--GEFACA 862
N G C L C PG+R C E+ +D C P + QC G ++C
Sbjct: 1198 NGGTCIDLVNHFKCSCPPGTRGLLCEEN--ID----DCARGPHCLNGGQCMDRIGGYSC- 1250
Query: 863 NSRCIQ--ERWKCDGD-NDCLDN--SDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGD 917
RC+ +C+GD N+CL N S E C Q T N +LC
Sbjct: 1251 --RCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLT---------------NDYLCV-- 1291
Query: 918 NDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCF 977
C ++ + CP Q C +G +CA +
Sbjct: 1292 --CRSAFTGRHCETFVDVCP--QMPCLNG----------------------GTCAVASNM 1325
Query: 978 PLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSG-RCIPE----HW 1032
P F C C A C SC Q KC G +C+
Sbjct: 1326 P-DGFICR----------------CPPGFSGARCQSSCG--QVKCRKGEQCVHTASGPRC 1366
Query: 1033 TCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSS 1092
C DC + C + + G CH P + C C
Sbjct: 1367 FCPSPRDC-------ESGCASSPCQHGGSCHPQRQ---------PPYYSCQ----CAPPF 1406
Query: 1093 DEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPC 1152
CE + PS S C KA D +E C S AC+ C
Sbjct: 1407 SGSRCE--LYTAPPSTPPATCLSQYCADKA---------RDGVCDEACNSHACQWDGGDC 1455
Query: 1153 A----NNTSVCLPPDKLCDG-NDDCGDGSDEGELCD--QCSLNNGGCSHNCSVAPGEGIV 1205
+ N + C P D N+ C ELC+ +C +N C N
Sbjct: 1456 SLTMENPWANCSSPLPCWDYINNQCD------ELCNTVECLFDNFECQGN---------- 1499
Query: 1206 CSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLD 1265
+ TC+ YCA H K CDQ S +C GW DG C +
Sbjct: 1500 ------------SKTCKYDKYCADHFK-DNHCDQGCNSEEC----GW----DGLDCAADQ 1538
Query: 1266 P 1266
P
Sbjct: 1539 P 1539
Score = 43.5 bits (101), Expect = 0.005
Identities = 44/165 (26%), Positives = 60/165 (36%), Gaps = 46/165 (27%)
Query: 34 CRDQITC--ISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRL 91
C++ TC + G+RC C G K CQ N C S
Sbjct: 766 CQNGGTCDNLVNGYRCT----CKKGF----------KGYNCQVNIDECA--------SNP 803
Query: 92 CNGVQDCMDGSD----------EGPHCRELQGNCSRLGCQHHCV----PTLDGPTCYCNS 137
C C D G +C+ + CS C++ V P + TC C
Sbjct: 804 CLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAP 863
Query: 138 SFQLQADGKTCK-DFDECSVYGTCSQ--LCTNTDGSFICGCVEGY 179
+Q G+ C D DEC + C LC NT GS++C C G+
Sbjct: 864 GWQ----GQRCTIDIDEC-ISKPCMNHGLCHNTQGSYMCECPPGF 903
Score = 43.5 bits (101), Expect = 0.005
Identities = 74/326 (22%), Positives = 100/326 (30%), Gaps = 48/326 (14%)
Query: 3288 DVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFY---LGSDGRTCVSNCTASQFVCKND 3344
D P +N G C + GG+ C C F D C+SN +S+
Sbjct: 1228 DCARGPHCLNGGQCMDRI-----GGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCI 1282
Query: 3345 KCIPFWWKCDTEDDCGDHSDEPPD-CPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNS 3403
+ + G H + D CP+ C G C+ FIC C
Sbjct: 1283 QLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGG-TCAVASNMPDGFICR----CPPGF 1337
Query: 3404 DEANCDIHVCLPSQFKCTNTNRCI-----PGIFRCNGQDNCGDGEDERDCPEV-TCAPNQ 3457
A C Q KC +C+ P F C +C G C +C P +
Sbjct: 1338 SGARCQSSC---GQVKCRKGEQCVHTASGPRCF-CPSPRDCESGCASSPCQHGGSCHPQR 1393
Query: 3458 FQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTC------GVDEFRCK------DSG 3505
+ +C P + S PA C C GV + C D G
Sbjct: 1394 QPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGG 1453
Query: 3506 RC---IPARW-KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDC 3561
C + W C C D + +CDE C + N C C YD C
Sbjct: 1454 DCSLTMENPWANCSSPLPCWDYINN---QCDE-LCNTVECLFDNFECQGNSKTCKYDKYC 1509
Query: 3562 G----DNSDEESCTPRPCSESEFSCA 3583
DN ++ C C CA
Sbjct: 1510 ADHFKDNHCDQGCNSEECGWDGLDCA 1535
Score = 40.0 bits (92), Expect = 0.053
Identities = 42/158 (26%), Positives = 63/158 (39%), Gaps = 26/158 (16%)
Query: 34 CRDQITCISKGWRCDGERDCPDGSDEA----PEI-CPQSKAQRCQPNEHNCLGTELCVPM 88
C+++ TC+ K + + + CP G A P + C + ++R EH C + +C+
Sbjct: 1072 CKNKGTCVQK--KAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINA 1129
Query: 89 SRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQH--HCVPTLDGPTCYCNSSFQLQADGK 146
C G G +C E C+ CQH C + G C C +Q G
Sbjct: 1130 GN--THYCQCPLGYT-GSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQ----GV 1182
Query: 147 TCK-DFDECSVY-----GTCSQLCTNTDGSFICGCVEG 178
C+ + DEC GTC L + F C C G
Sbjct: 1183 NCEYEVDECQNQPCQNGGTCIDLVNH----FKCSCPPG 1216
Score = 38.9 bits (89), Expect = 0.12
Identities = 41/168 (24%), Positives = 60/168 (35%), Gaps = 20/168 (11%)
Query: 27 CSPK---QFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQS-KAQRCQPNEHNCLGT 82
C P+ QF D C+ + C C + + +C C N +C
Sbjct: 286 CPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFA 345
Query: 83 ELCVPMSRLCNGVQD--CMDGSDEGPHCRELQGNCSRLGCQHHCV----PTLDGPTCYCN 136
C P S + V CM + L C C + P C C
Sbjct: 346 S-CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCP 404
Query: 137 SSFQLQADGKTC-KDFDECSVYGT--CSQL--CTNTDGSFICGCVEGY 179
++ G C +D DEC++ + C C NTDG+F C C++GY
Sbjct: 405 QGYK----GADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY 448
Score = 38.9 bits (89), Expect = 0.12
Identities = 126/615 (20%), Positives = 189/615 (30%), Gaps = 132/615 (21%)
Query: 2473 DTNSCELSPCRINNGGCQDL-------CLLTHQGHVNCS-----CRGGRILQDDLTCRAV 2520
D N C PC+ N G C D C G V+C C +
Sbjct: 949 DMNECLSEPCK-NGGTCSDYVNSYTCKCQAGFDG-VHCENNINECTESSCFNGGTCVDGI 1006
Query: 2521 NS-SCRAQDEF----------ECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKT 2569
NS SC F EC++ C+N DG+ + P + C+
Sbjct: 1007 NSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSC---PLGYTGKNCQTL 1063
Query: 2570 FRQCSN------GRCVSNML---------WCNGADDCGDGSDEIPCNKTACGVGEFRCRD 2614
CS G CV W D + S +I ++ V
Sbjct: 1064 VNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHS 1123
Query: 2615 GTCI--GNSSRCNQFVD-----CEDASDEMNCSATDCS----------SYFRLGVKGVLF 2657
G CI GN+ C + CE+ DE C++ C Y V G
Sbjct: 1124 GVCINAGNTHYCQCPLGYTGSYCEEQLDE--CASNPCQHGATCSDFIGGYRCECVPGYQG 1181
Query: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDERDC---PGVKRPRCPLNYFACPSG-RCIPMSW 2713
CE + + C C D + C PG + C N C G C+
Sbjct: 1182 VNCEY-EVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQ 1240
Query: 2714 TCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-------- 2765
D+ G C + + E + C+S +GS DC +++
Sbjct: 1241 CMDRI-----GGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSA 1295
Query: 2766 --AAHCEGKTCGPSSFSCPGTHVC-----VPERWLCDGDKDCADGADESIAAGCLYNSTC 2818
HCE C C +P+ ++C C G +G S+C
Sbjct: 1296 FTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICR----CPPGF-----SGARCQSSC 1346
Query: 2819 DDREFMCQN-RQCI-----PKHFVCDHDRDCADGSDESPECE-----YPTCGPSEFRCAN 2867
+ C+ QC+ P+ F C RDC G SP C+ +P P + C
Sbjct: 1347 G--QVKCRKGEQCVHTASGPRCF-CPSPRDCESGCASSP-CQHGGSCHPQRQPPYYSCQC 1402
Query: 2868 GRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQ 2927
S + E P P T C ++ C + A +G
Sbjct: 1403 APPFSGSRCEL---------YTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDG- 1452
Query: 2928 DDCGDSSDERGCHINE---CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVD 2984
DC + + + + C + C + C ++ F F + + +TC
Sbjct: 1453 GDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLF-----DNFECQGNSKTCKYDK 1507
Query: 2985 ECSTTFP---CSQRC 2996
C+ F C Q C
Sbjct: 1508 YCADHFKDNHCDQGC 1522
Score = 37.7 bits (86), Expect = 0.26
Identities = 38/152 (25%), Positives = 60/152 (39%), Gaps = 17/152 (11%)
Query: 34 CRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCN 93
C++ TC+++ G+ C S E C S + C + CL C +SR
Sbjct: 73 CQNGGTCVAQAML--GKATCRCASGFTGEDCQYSTSHPCFVSRP-CLNGGTCHMLSR--- 126
Query: 94 GVQDCM-DGSDEGPHCRELQGNCSRLGCQHH--CVPTLDGPTCYCNSSFQLQADGKTCK- 149
+C G C+ C C + C + +C C + F G+ C+
Sbjct: 127 DTYECTCQVGFTGKECQWTDA-CLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCET 181
Query: 150 DFDECSVYGTCSQ--LCTNTDGSFICGCVEGY 179
D +EC + G C C N GS+ C C +G+
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF 213
Score = 36.6 bits (83), Expect = 0.58
Identities = 35/165 (21%), Positives = 58/165 (35%), Gaps = 14/165 (8%)
Query: 1105 DPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRP--PSHPCANNTSVCLPP 1162
DP K C++ C+++A + C E+C+ P S PC N + +
Sbjct: 66 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 125
Query: 1163 DKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCP---LGMELGPDNH 1219
+ G E + D C + C+ + C C G + D +
Sbjct: 126 RDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQ-FSCKCLTGFTGQKCETDVN 184
Query: 1220 TCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264
C I +C + C S +C C +G+ G+ C SL
Sbjct: 185 ECDIPGHC----QHGGTCLNLPGSYQCQCPQGFT----GQYCDSL 221
Score = 36.6 bits (83), Expect = 0.58
Identities = 66/305 (21%), Positives = 103/305 (33%), Gaps = 72/305 (23%)
Query: 817 LCLATPGSRQCACAED---QVLDADGVTCLANPSYVPPP---QCQPGEFACANSRCIQER 870
+C + R C D Q+ +G TC A S +P +C PG F+ A + +
Sbjct: 1291 VCRSAFTGRHCETFVDVCPQMPCLNGGTC-AVASNMPDGFICRCPPG-FSGARCQSSCGQ 1348
Query: 871 WKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNAT 930
KC C+ HT R C + R D ++ C +S + +
Sbjct: 1349 VKCRKGEQCV------------HTASGPRCFCPSPR--------DCESGCASSPCQHGGS 1388
Query: 931 CSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFP-----LTQFTCN 985
C + PP +SC +C P + S A+C C + CN
Sbjct: 1389 CHPQRQPP-YYSC---QCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACN 1444
Query: 986 NGRC----------ININW-RCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTC 1034
+ C + W C + C D + C C++ + ++ C TC
Sbjct: 1445 SHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQ-CDELCNTVECLFDNFECQGNSKTC 1503
Query: 1035 DGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDE 1094
D C D+ + H + GC+++E C DGL DC E
Sbjct: 1504 KYDKYCADHFKDNHCD---------QGCNSEE--CGWDGL------------DCAADQPE 1540
Query: 1095 KSCEG 1099
EG
Sbjct: 1541 NLAEG 1545
Score = 35.4 bits (80), Expect = 1.3
Identities = 66/298 (22%), Positives = 97/298 (32%), Gaps = 43/298 (14%)
Query: 2473 DTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFEC 2532
D N C +PC ++ G D LT+ C CR T R + + C
Sbjct: 1264 DINECLSNPC--SSEGSLDCIQLTND--YLCVCRSA------FTGRHCETFVDVCPQMPC 1313
Query: 2533 ANG-ECINFSLTCDG-VPHCKD--KSDEKPSYCNSRRCKKTFRQC----SNGRCVSNMLW 2584
NG C S DG + C S C +C+K QC S RC +
Sbjct: 1314 LNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKG-EQCVHTASGPRC-----F 1367
Query: 2585 CNGADDCGDGSDEIPCNKTACGVGE-----FRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
C DC G PC + + C+ + SRC + ++ C
Sbjct: 1368 CPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPF-SGSRCELYT-APPSTPPATC 1425
Query: 2640 SATDCSSYFRLGV--KGVLFQPCE----RTSLCYAPSWV-CDGANDCGDYSDERDCPGVK 2692
+ C+ R GV + C+ SL W C C DY + +
Sbjct: 1426 LSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCN 1485
Query: 2693 RPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQ 2750
C + F C S TC + C + HC++ C+ + C + Q
Sbjct: 1486 TVECLFDNFECQGN-----SKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQ 1538
Score = 34.3 bits (77), Expect = 2.9
Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 13/107 (12%)
Query: 40 CISKGWRCDGERDCPDGSDEAPEICPQSKAQR-CQP-----NEHNCLGTELCVPMSRLCN 93
C+S +G DC +++ +C + R C+ + CL C S + +
Sbjct: 1268 CLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD 1327
Query: 94 G-VQDCMDGSDEGPHCRELQGNCSRLGCQ--HHCVPTLDGPTCYCNS 137
G + C G G C Q +C ++ C+ CV T GP C+C S
Sbjct: 1328 GFICRCPPGFS-GARC---QSSCGQVKCRKGEQCVHTASGPRCFCPS 1370
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 120 bits (300), Expect = 4e-26
Identities = 105/351 (29%), Positives = 153/351 (43%), Gaps = 51/351 (14%)
Query: 4146 EVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRL-DNGTCVPVPSPTPPPDAPRPGTCNLQ- 4203
E + C RK C+ + C N K+ N TCV +P T + C L
Sbjct: 348 EEYDACQRKPCQ-------NNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDP 400
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCE--LDQCWEH-CRNGGTCAASPSGMPTCRCPT 4260
C NG +C +++ C+C Y G CE +D C C+N GTC TC C
Sbjct: 401 CRNGATC-ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF-TCNCSP 458
Query: 4261 GFTGPKCTQQV--CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRC--QYRQC-SGYCENF 4315
GFTGP C Q + CA + TC + G +C C PG+ G C +Y +C S C N
Sbjct: 459 GFTGPTCAQLIDFCALSPCAHGTCR-SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNA 517
Query: 4316 GTCQMAADGSRQCRCTAYFEGSRCEVNK--CSR--CLEGA-CVVNKQSGDVTCNCTDGRV 4370
TC+ +G +C C A ++G+ CE+ K C+ CL GA C + +G TC C G
Sbjct: 518 ATCRDLVNG-YECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG--TCICAPGFT 574
Query: 4371 APSCLTCVGHCS-----NGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASIL 4425
C + C +GGSC ++ C CP G CE H+ Q + GH+A L
Sbjct: 575 GEECDIDINECDSNPCHHGGSC-LDQPNGYNCHCPHGWVGANCEIHL--QWKSGHMAESL 631
Query: 4426 IPL---------------LLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTN 4461
+ +L+L++L+ G+ + QG+ ++ N
Sbjct: 632 TNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYN 682
Score = 45.8 bits (107), Expect = 0.001
Identities = 30/100 (30%), Positives = 39/100 (39%), Gaps = 17/100 (17%)
Query: 4187 SPTPPPDAPRPGTCNLQ-CFNGGSCFLNARRQPK-----------CRCQPRYTGDKCEL- 4233
+P P PG C Q C NGG C P+ C C +G C+L
Sbjct: 35 NPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLV 94
Query: 4234 -DQCWEHCRNGGTCAASPSGMPT---CRCPTGFTGPKCTQ 4269
D C + + G C++S S C C G+ GP C Q
Sbjct: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 43.1 bits (100), Expect = 0.006
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 20/83 (24%)
Query: 4240 CRNGGTCAA---------SPSGMP--TCRCPTGFTGPKCTQQVCAGYCANN-------ST 4281
CRNGG C + +P+G P +C CP G +G C Q+ A CA+N S+
Sbjct: 53 CRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC--QLVADPCASNPCHHGNCSS 110
Query: 4282 CTVNQGNQPQCRCLPGFLGDRCQ 4304
+ + + C C G+ G C+
Sbjct: 111 SSSSSSDGYLCICNEGYEGPNCE 133
Score = 41.6 bits (96), Expect = 0.018
Identities = 21/52 (40%), Positives = 26/52 (50%), Gaps = 5/52 (9%)
Query: 2961 IGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQ-RCINTHGSYKCLCVEGY 3011
+ F C C PGF G TCA + + PC+ C + SYKCLC GY
Sbjct: 450 VHFTCNCSPGFT----GPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497
Score = 38.9 bits (89), Expect = 0.12
Identities = 43/204 (21%), Positives = 68/204 (33%), Gaps = 33/204 (16%)
Query: 1027 CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQ----CRLDGLCIPLRWRC 1082
C+P G++ D CT + + C +E C C R C
Sbjct: 307 CVP------GESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC--QRKPC 358
Query: 1083 DGDTDCMDSSDEKSCEGVTHVCDPS-------------VKFGCKDSARCIS--KAWVCDG 1127
+ C+D+++++ T VC P + C++ A CIS + C
Sbjct: 359 QNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTC-- 416
Query: 1128 DNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSL 1187
C + CE S PC NN + + G +L D C+L
Sbjct: 417 --QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCAL 474
Query: 1188 NNGGCSHNCSVAPGEGIVCSCPLG 1211
+ C+H + G C C G
Sbjct: 475 S--PCAHGTCRSVGTSYKCLCDPG 496
Score = 38.1 bits (87), Expect = 0.20
Identities = 40/148 (27%), Positives = 56/148 (37%), Gaps = 10/148 (6%)
Query: 34 CRDQITCISKGWRCDGER-DCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLC 92
C++ +CI + DG C E+C QSK C + C C+ S L
Sbjct: 358 CQNNASCIDANEKQDGSNFTCVCLPGYTGELC-QSKIDYCILDP--CRNGATCI--SSLS 412
Query: 93 NGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKD-F 151
C +G G C E C+ CQ++ +DG CN S G TC
Sbjct: 413 GFTCQCPEGYF-GSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGF--TGPTCAQLI 469
Query: 152 DECSVYGTCSQLCTNTDGSFICGCVEGY 179
D C++ C + S+ C C GY
Sbjct: 470 DFCALSPCAHGTCRSVGTSYKCLCDPGY 497
Score = 33.5 bits (75), Expect = 5.0
Identities = 29/120 (24%), Positives = 38/120 (31%), Gaps = 24/120 (20%)
Query: 2912 CSSGRCVAEALLCNGQDDCGDSSDERG-------------CHINECLSRKLSGCSQDCED 2958
C G A L C+G+ C E C + RK + C D
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCID 366
Query: 2959 LK-----IGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQ--RCINTHGSYKCLCVEGY 3011
F C C PG+ G C + PC CI++ + C C EGY
Sbjct: 367 ANEKQDGSNFTCVCLPGYT----GELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGY 422
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 116 bits (291), Expect = 4e-25
Identities = 70/214 (32%), Positives = 90/214 (42%), Gaps = 29/214 (13%)
Query: 4200 CNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCP 4259
CN C +GG+C C C + G +CE C HC NGG C C+C
Sbjct: 1362 CNPPCQHGGTCLAGNL----CTCPYGFVGPRCETMVCNRHCENGGQCLTPD----ICQCK 1413
Query: 4260 TGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQ-CRCLPGFLGDRCQYRQCSGYCENFGTC 4318
G+ GP C+ +C C N +C N+P C C GF G+ CQ C C+N G C
Sbjct: 1414 PGWYGPTCSTALCDPVCLNGGSC-----NKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHC 1468
Query: 4319 QMAADGSRQCRCTAYFEGSRCEVNKCS-RCLEGACVVNKQSGDVTCNCTDGRVAPSCLT- 4376
+ C C + G R + + C C+ G V G TC+C G C T
Sbjct: 1469 MR----NNVCVCREGYTGRRFQKSICDPTCMNGGKCV----GPSTCSCPSGWSGKRCNTP 1520
Query: 4377 -CVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCE 4409
C+ C NGG C S C CP G RC+
Sbjct: 1521 ICLQKCKNGGECIAPS----ICHCPSSWEGVRCQ 1550
Score = 97.4 bits (241), Expect = 3e-19
Identities = 64/196 (32%), Positives = 86/196 (43%), Gaps = 23/196 (11%)
Query: 4220 CRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANN 4279
C+C+P Y G C+ C C+N G C P+ C+C G G C ++ C C +
Sbjct: 1314 CKCKPGYIGSNCQTALCDPDCKNHGKC-IKPN---ICQCLPGHGGATCDEEHCNPPCQHG 1369
Query: 4280 STCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRC 4339
TC GN C C GF+G RC+ C+ +CEN G C + D C+C + G C
Sbjct: 1370 GTCLA--GN--LCTCPYGFVGPRCETMVCNRHCENGGQC-LTPD---ICQCKPGWYGPTC 1421
Query: 4340 EVNKCSR-CLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH--CSNGGSCTMNSKMMPE 4396
C CL G NK + TC C +G C H C NGG C N+
Sbjct: 1422 STALCDPVCLNGGS-CNKPN---TCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNN----V 1473
Query: 4397 CQCPPHMTGPRCEEHV 4412
C C TG R ++ +
Sbjct: 1474 CVCREGYTGRRFQKSI 1489
Score = 90.1 bits (222), Expect = 4e-17
Identities = 67/234 (28%), Positives = 87/234 (37%), Gaps = 63/234 (26%)
Query: 4151 CDRKKCEWLCLLSPS---GPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGT--CNLQCF 4205
CD + C C + G +CTCP G PR T CN C
Sbjct: 1357 CDEEHCNPPCQHGGTCLAGNLCTCPYGFV-----------------GPRCETMVCNRHCE 1399
Query: 4206 NGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGP 4265
NGG C C+C+P + G C C C NGG+C P+ TC CP GF G
Sbjct: 1400 NGGQCLT----PDICQCKPGWYGPTCSTALCDPVCLNGGSCN-KPN---TCLCPNGFFGE 1451
Query: 4266 KCTQQVC------AGYCANNSTCTVNQG----------------------NQPQCRCLPG 4297
C C G+C N+ C +G C C G
Sbjct: 1452 HCQNAFCHPPCKNGGHCMRNNVCVCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSG 1511
Query: 4298 FLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS-RCLEG 4350
+ G RC C C+N G C + C C + +EG RC++ C+ +CL G
Sbjct: 1512 WSGKRCNTPICLQKCKNGGECIAPSI----CHCPSSWEGVRCQIPICNPKCLYG 1561
Score = 85.1 bits (209), Expect = 1e-15
Identities = 57/196 (29%), Positives = 72/196 (36%), Gaps = 40/196 (20%)
Query: 4151 CDRKKCEWLCLLSPS---GPVCTCPNG---KRLDNGTCVPVPSPTPPPDAPRPGTCNLQC 4204
C C+ +CL S C CPNG + N C P C
Sbjct: 1421 CSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHP------------------PC 1462
Query: 4205 FNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTG 4264
NGG C R C C+ YTG + + C C NGG C G TC CP+G++G
Sbjct: 1463 KNGGHCM----RNNVCVCREGYTGRRFQKSICDPTCMNGGKCV----GPSTCSCPSGWSG 1514
Query: 4265 PKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADG 4324
+C +C C N C C C + G RCQ C+ C G C
Sbjct: 1515 KRCNTPICLQKCKNGGECIA----PSICHCPSSWEGVRCQIPICNPKCLYGGRCIF---- 1566
Query: 4325 SRQCRCTAYFEGSRCE 4340
C C + G +CE
Sbjct: 1567 PNVCSCRTEYSGVKCE 1582
Score = 81.6 bits (200), Expect = 2e-14
Identities = 68/265 (25%), Positives = 89/265 (33%), Gaps = 86/265 (32%)
Query: 4204 CFNGGSCFLNARRQPK-----CRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPT--- 4255
C NGGSC + P C C P + G CE+D C ++P G+ +
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDI--------SGCQSNPCGLGSYIS 1234
Query: 4256 ------CRCP------TGFTGPKCTQQV-------------------------------- 4271
C CP T F TQ V
Sbjct: 1235 GFHSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNA 1294
Query: 4272 ---CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQC 4328
C C + C C+C PG++G CQ C C+N G C C
Sbjct: 1295 FTICKYPCGKSRECVAPN----ICKCKPGYIGSNCQTALCDPDCKNHGKCIK----PNIC 1346
Query: 4329 RCTAYFEGSRCEVNKCSRCLE--GACVVNKQSGDVTCNCTDGRVAPSC--LTCVGHCSNG 4384
+C G+ C+ C+ + G C+ C C G V P C + C HC NG
Sbjct: 1347 QCLPGHGGATCDEEHCNPPCQHGGTCLAGN-----LCTCPYGFVGPRCETMVCNRHCENG 1401
Query: 4385 GSCTMNSKMMPE-CQCPPHMTGPRC 4408
G C + P+ CQC P GP C
Sbjct: 1402 GQC-----LTPDICQCKPGWYGPTC 1421
Score = 45.8 bits (107), Expect = 0.001
Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 19/107 (17%)
Query: 4170 TCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNL-----QCFNGGSCFLNARRQPKCRCQP 4224
TC NG G CV PS P CN +C NGG C + C C
Sbjct: 1493 TCMNG-----GKCVG-PSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPSI----CHCPS 1542
Query: 4225 RYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQV 4271
+ G +C++ C C GG C C C T ++G KC +++
Sbjct: 1543 SWEGVRCQIPICNPKCLYGGRCIFPN----VCSCRTEYSGVKCEKKI 1585
Score = 36.2 bits (82), Expect = 0.76
Identities = 74/330 (22%), Positives = 108/330 (32%), Gaps = 43/330 (13%)
Query: 3529 EECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRP------CSESEFSC 3582
++CD T + K+ C+ G C D + S C P C C
Sbjct: 1164 DDCDAETRVTIEVTVKSCDCLNGG-SCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGC 1222
Query: 3583 ANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMD-QFQCKSGHCIPLRWRCDADADCMDG 3641
+ C G + G H S DC P ++ QF + + R D + +
Sbjct: 1223 QSNPCGLGSY-ISGFH-----SYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVN-KEE 1275
Query: 3642 SDEEACGTGVRTCPLDEFQCNNTLCKPLAWK---CDGEDDCGDNSDENPEECARFVCPPN 3698
D+ A G P T+CK K C + C C +C P+
Sbjct: 1276 DDKNAQGRKRHVKPTSGNAF--TICKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPD 1333
Query: 3699 RPFRCKNDRVCLWIGRQCDGTDNCGDGT-DEEDCEPPTAHTTHCKDKKEFLCR----NQR 3753
CKN C+ C G T DEE C PP H C C R
Sbjct: 1334 ----CKNHGKCIK-PNICQCLPGHGGATCDEEHCNPPCQHGGTCLAGNLCTCPYGFVGPR 1388
Query: 3754 CLSSSLRCNMF-DDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVR---TEKAAYCAC 3809
C ++ CN ++ G + C P + ++C + C+ K C C
Sbjct: 1389 C--ETMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTALC--DPVCLNGGSCNKPNTCLC 1444
Query: 3810 RSGFHTVPGQ-----PGCQDINECLRFGTC 3834
+GF Q P C++ C+R C
Sbjct: 1445 PNGFFGEHCQNAFCHPPCKNGGHCMRNNVC 1474
Score = 34.3 bits (77), Expect = 2.9
Identities = 43/180 (23%), Positives = 56/180 (31%), Gaps = 54/180 (30%)
Query: 1101 THVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSH---------- 1150
T +CDP CK+ +CI K +C C C+ C PP
Sbjct: 1327 TALCDPD----CKNHGKCI-KPNICQ----CLPGHGGATCDEEHCNPPCQHGGTCLAGNL 1377
Query: 1151 -PC-----------------ANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGC 1192
C N CL PD +C + LCD LN G C
Sbjct: 1378 CTCPYGFVGPRCETMVCNRHCENGGQCLTPD-ICQCKPGWYGPTCSTALCDPVCLNGGSC 1436
Query: 1193 SHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGW 1252
+ + C CP G CQ ++C K C +N C C EG+
Sbjct: 1437 N--------KPNTCLCPNGF----FGEHCQ-NAFCHPPCKNGGHCMRNNV---CVCREGY 1480
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 115 bits (287), Expect = 1e-24
Identities = 60/133 (45%), Positives = 73/133 (54%), Gaps = 11/133 (8%)
Query: 3562 GDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP---RCDMDQF 3618
G+N E P F C+NGRCI G W+CDG DC D SDEK+C +C F
Sbjct: 22 GNNFTNECNIP-----GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
Query: 3619 QCKSG-HCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGED 3677
C SG HCI R+RC+ DC DGSDEE C C + C N LC ++ CDG++
Sbjct: 77 PCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQN 136
Query: 3678 DCGDNSDENPEEC 3690
+C DNSDE E C
Sbjct: 137 NCQDNSDE--ESC 147
Score = 108 bits (269), Expect = 2e-22
Identities = 54/128 (42%), Positives = 71/128 (55%), Gaps = 5/128 (3%)
Query: 3486 PANCTQMTCGVD-EFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCK 3544
P N C + F C + GRCIP W+CDG DC D SDE + + C P F C
Sbjct: 21 PGNNFTNECNIPGNFMCSN-GRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA 79
Query: 3545 NN-RCVPGRWQCDYDNDCGDNSDEESCTPRP--CSESEFSCANGRCIAGRWKCDGDHDCA 3601
+ C+ GR++C+ DC D SDEE+CT P CS + + C NG CI + CDG ++C
Sbjct: 80 SGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQ 139
Query: 3602 DGSDEKDC 3609
D SDE+ C
Sbjct: 140 DNSDEESC 147
Score = 108 bits (269), Expect = 2e-22
Identities = 53/123 (43%), Positives = 72/123 (58%), Gaps = 8/123 (6%)
Query: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
F C++GRCIP W CDG DC D SDE + + C F C CI R
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE------KECPKAKSKCGPTFFPCASGIHCIIGR 88
Query: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
+RC+G DC D SDE++C +C + ++ CK+ CI K+++CDG N+C+DNSDEE+
Sbjct: 89 FRCNGFEDCPDGSDEENCTANPLLCS-TARYHCKNGL-CIDKSFICDGQNNCQDNSDEES 146
Query: 1140 CES 1142
CES
Sbjct: 147 CES 149
Score = 103 bits (257), Expect = 4e-21
Identities = 49/124 (39%), Positives = 67/124 (54%), Gaps = 3/124 (2%)
Query: 2522 SSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG-RCVS 2580
+ C F C+NG CI + CDG+P C DKSDEK +C TF C++G C+
Sbjct: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCII 86
Query: 2581 NMLWCNGADDCGDGSDEIPC--NKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMN 2638
CNG +DC DGSDE C N C + C++G CI S C+ +C+D SDE +
Sbjct: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 2639 CSAT 2642
C ++
Sbjct: 147 CESS 150
Score = 101 bits (252), Expect = 1e-20
Identities = 51/118 (43%), Positives = 62/118 (52%), Gaps = 4/118 (3%)
Query: 3455 PNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC--TQMTCGVDEFRCKDSGRCIPARW 3512
P F CS RCIP W CD DC D SDE C + CG F C CI R+
Sbjct: 32 PGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEK-ECPKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
+C+G +DC DGSDE + C ++ CKN C+ + CD N+C DNSDEESC
Sbjct: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 101 bits (252), Expect = 1e-20
Identities = 49/116 (42%), Positives = 60/116 (51%), Gaps = 1/116 (0%)
Query: 900 FKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASG-RCIPISWTCDLD 958
F C N RCIP W CDG DC + DE + C P F CASG CI + C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 959 DDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHS 1014
+DC D SDE A P ++ C NG CI+ ++ CD N+C DNSDE C S
Sbjct: 95 EDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
Score = 100 bits (249), Expect = 3e-20
Identities = 62/166 (37%), Positives = 81/166 (48%), Gaps = 17/166 (10%)
Query: 3304 LCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTA-SQFVCKNDKCIPFWWKCDTEDDCGDH 3362
LCLL P N + + C F+C N +CIP W+CD DC D
Sbjct: 7 LCLLLSSAAESQLLPGNNF--------TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDK 58
Query: 3363 SDEPPDCP--EFKCRPGQFQCSTGI-CTNPAFICDGDNDCQDNSDEANCDIH--VCLPSQ 3417
SDE +CP + KC P F C++GI C F C+G DC D SDE NC + +C ++
Sbjct: 59 SDE-KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
Query: 3418 FKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT 3463
+ C N CI F C+GQ+NC D DE C E + P Q +T
Sbjct: 118 YHCKN-GLCIDKSFICDGQNNCQDNSDEESC-ESSQEPGSGQVFVT 161
Score = 97.8 bits (242), Expect = 2e-19
Identities = 54/133 (40%), Positives = 68/133 (51%), Gaps = 13/133 (9%)
Query: 1059 PGGCHTDE------FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC 1112
PG T+E F C +G CIP W+CDG DC D SDEK C C P+ F C
Sbjct: 21 PGNNFTNECNIPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF-FPC 78
Query: 1113 KDSARCISKAWVCDGDNDCEDNSDEENCES--LACRPPSHPCANNTSVCLPPDKLCDGND 1170
CI + C+G DC D SDEENC + L C + C N +C+ +CDG +
Sbjct: 79 ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNG--LCIDKSFICDGQN 136
Query: 1171 DCGDGSDEGELCD 1183
+C D SDE E C+
Sbjct: 137 NCQDNSDE-ESCE 148
Score = 97.1 bits (240), Expect = 4e-19
Identities = 50/114 (43%), Positives = 66/114 (57%), Gaps = 6/114 (5%)
Query: 938 PNQFSCASGRCIPISWTCDLDDDCGDRSDE-SASCAYPTCFPLTQFTCNNG-RCININWR 995
P F C++GRCIP +W CD DC D+SDE A C P T F C +G CI +R
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGP-TFFPCASGIHCIIGRFR 90
Query: 996 CDNDNDCGDNSDEAGCSHS---CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
C+ DC D SDE C+ + CS+ ++ C +G CI + + CDG N+C D SDE
Sbjct: 91 CNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 95.9 bits (237), Expect = 8e-19
Identities = 52/140 (37%), Positives = 73/140 (52%), Gaps = 7/140 (5%)
Query: 3414 LPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVT--CAPNQFQCSITKRCIPRVW 3471
+P F C+N RCIPG ++C+G +C D DE++CP+ C P F C+ CI +
Sbjct: 31 IPGNFMCSN-GRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 3472 VCDRDNDCVDGSDEPANCTQ--MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKE 3529
C+ DC DGSDE NCT + C + CK+ G CI + CDG+++C D SDE
Sbjct: 90 RCNGFEDCPDGSDEE-NCTANPLLCSTARYHCKN-GLCIDKSFICDGQNNCQDNSDEESC 147
Query: 3530 ECDERTCEPYQFRCKNNRCV 3549
E + F N+ V
Sbjct: 148 ESSQEPGSGQVFVTSENQLV 167
Score = 95.9 bits (237), Expect = 8e-19
Identities = 46/109 (42%), Positives = 63/109 (57%), Gaps = 6/109 (5%)
Query: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSG-RCIPMSWTCDKEDDCEHG 2724
C +W CDG DC D SDE++CP K +C +F C SG CI + C+ +DC G
Sbjct: 42 CIPGAWQCDGLPDCFDKSDEKECPKAK-SKCGPTFFPCASGIHCIIGRFRCNGFEDCPDG 100
Query: 2725 EDETHCNK---FCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
DE +C CS A++ C+N CI K ++CDG ++C D SDE + CE
Sbjct: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES-CE 148
Score = 95.1 bits (235), Expect = 1e-18
Identities = 48/114 (42%), Positives = 62/114 (54%), Gaps = 5/114 (4%)
Query: 3376 PGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGIFRC 3433
PG F CS G C A+ CDG DC D SDE C C P+ F C + CI G FRC
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
Query: 3434 NGQDNCGDGEDERDCP--EVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
NG ++C DG DE +C + C+ ++ C CI + ++CD N+C D SDE
Sbjct: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDE 144
Score = 94.4 bits (233), Expect = 2e-18
Identities = 52/147 (35%), Positives = 83/147 (56%), Gaps = 11/147 (7%)
Query: 2801 ADGADESIAAGCLYNSTCD-DREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPT-- 2857
+ A+ + G + + C+ FMC N +CIP + CD DC D SDE EC
Sbjct: 12 SSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEK-ECPKAKSK 70
Query: 2858 CGPSEFRCANG-RCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGR 2916
CGP+ F CA+G C+ R + C+G DC D SDE +CT+ C+ ++++ C +G
Sbjct: 71 CGPTFFPCASGIHCIIGR-FRCNGFEDCPDGSDEE----NCTANPLLCS-TARYHCKNGL 124
Query: 2917 CVAEALLCNGQDDCGDSSDERGCHINE 2943
C+ ++ +C+GQ++C D+SDE C ++
Sbjct: 125 CIDKSFICDGQNNCQDNSDEESCESSQ 151
Score = 91.7 bits (226), Expect = 2e-17
Identities = 54/127 (42%), Positives = 63/127 (49%), Gaps = 15/127 (11%)
Query: 2573 CSNGRCVSNMLWCNGADDCGDGSDEIPCNK--TACGVGEFRCRDGT-CIGNSSRCNQFVD 2629
CSNGRC+ C+G DC D SDE C K + CG F C G CI RCN F D
Sbjct: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFED 96
Query: 2630 CEDASDEMNCSATD--CSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERD 2687
C D SDE NC+A CS+ R K LC S++CDG N+C D SDE
Sbjct: 97 CPDGSDEENCTANPLLCSTA-RYHCKN---------GLCIDKSFICDGQNNCQDNSDEES 146
Query: 2688 CPGVKRP 2694
C + P
Sbjct: 147 CESSQEP 153
Score = 88.6 bits (218), Expect = 1e-16
Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 7/119 (5%)
Query: 3659 FQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGR-QCD 3717
F C+N C P AW+CDG DC D SDE A+ C P F C + C+ IGR +C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF-FPCASGIHCI-IGRFRCN 92
Query: 3718 GTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
G ++C DG+DEE+C TA+ C + + C+N C+ S C+ ++C D SDEE C
Sbjct: 93 GFEDCPDGSDEENC---TANPLLCSTAR-YHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 87.4 bits (215), Expect = 3e-16
Identities = 47/125 (37%), Positives = 64/125 (51%), Gaps = 4/125 (3%)
Query: 3610 TPRCDMD-QFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTL-CK 3667
T C++ F C +G CIP W+CD DC D SDE+ C C F C + + C
Sbjct: 26 TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCI 85
Query: 3668 PLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTD 3727
++C+G +DC D SDE +C R + CKN +C+ CDG +NC D +D
Sbjct: 86 IGRFRCNGFEDCPDGSDEENCTANPLLCSTAR-YHCKNG-LCIDKSFICDGQNNCQDNSD 143
Query: 3728 EEDCE 3732
EE CE
Sbjct: 144 EESCE 148
Score = 80.1 bits (196), Expect = 5e-14
Identities = 41/112 (36%), Positives = 58/112 (51%), Gaps = 8/112 (7%)
Query: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKF---CSEAQFECQNH-RCISKQWLCDGS 2756
F C +GRCIP +W CD DC DE C K C F C + CI ++ C+G
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 2757 DDCGDGSDEAAHCEGK--TCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
+DC DGSDE +C C + + C +C+ + ++CDG +C D +DE
Sbjct: 95 EDCPDGSDE-ENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDE 144
Score = 75.1 bits (183), Expect = 1e-12
Identities = 42/130 (32%), Positives = 61/130 (46%), Gaps = 6/130 (4%)
Query: 804 TNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACAN 863
TN+C + S PG+ QC D +D C S +C P F CA+
Sbjct: 26 TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS-----KCGPTFFPCAS 80
Query: 864 S-RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGN 922
CI R++C+G DC D SDE + C + R+ C+N CI ++CDG N+C +
Sbjct: 81 GIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQD 140
Query: 923 SEDESNATCS 932
+ DE + S
Sbjct: 141 NSDEESCESS 150
Score = 73.6 bits (179), Expect = 4e-12
Identities = 40/101 (39%), Positives = 52/101 (51%), Gaps = 11/101 (10%)
Query: 2846 GSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN 2905
G++ + EC P F C+NGRC+ W+CDG DC D+SDE C + KC
Sbjct: 22 GNNFTNECNIP----GNFMCSNGRCIPGA-WQCDGLPDCFDKSDEK----ECPKAKSKCG 72
Query: 2906 ASSQFLCSSG-RCVAEALLCNGQDDCGDSSDERGCHINECL 2945
+ F C+SG C+ CNG +DC D SDE C N L
Sbjct: 73 PTF-FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL 112
Score = 63.2 bits (152), Expect = 6e-09
Identities = 44/124 (35%), Positives = 59/124 (47%), Gaps = 18/124 (14%)
Query: 3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLR 3760
F C N R C+ QCDG +C D +DE++C P A + C C+ R
Sbjct: 35 FMCSNGR-CIPGAWQCDGLPDCFDKSDEKEC--PKAKSK-CGPTFFPCASGIHCIIGRFR 90
Query: 3761 CNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQP 3820
CN F+DC DGSDEE+C+ +P L C+T C C+ +K+ C GQ
Sbjct: 91 CNGFEDCPDGSDEENCTANPLL--CSTARYHC-KNGLCI--DKSFIC---------DGQN 136
Query: 3821 GCQD 3824
CQD
Sbjct: 137 NCQD 140
Score = 62.4 bits (150), Expect = 1e-08
Identities = 49/157 (31%), Positives = 71/157 (45%), Gaps = 11/157 (7%)
Query: 1 MLTPPLLLLLPLLSALVAAAIDAPKTCS-PKQFACRDQITCISKGWRCDGERDCPDGSDE 59
+L P LLL + + + C+ P F C + CI W+CDG DC D SDE
Sbjct: 3 LLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNG-RCIPGAWQCDGLPDCFDKSDE 61
Query: 60 APEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLG 119
CP++K+ +C P C C+ CNG +DC DGSDE +C CS
Sbjct: 62 KE--CPKAKS-KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDE-ENCTANPLLCST-- 115
Query: 120 CQHHCVPTL---DGPTCYCNSSFQLQADGKTCKDFDE 153
++HC L C ++ Q +D ++C+ E
Sbjct: 116 ARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
Score = 50.8 bits (120), Expect = 3e-05
Identities = 38/128 (29%), Positives = 51/128 (39%), Gaps = 22/128 (17%)
Query: 3728 EEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCAT 3787
E P T C F+C N RC+ + +C+ DC D SDE++C PK
Sbjct: 16 ESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC---PKA----- 67
Query: 3788 NASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLC 3847
S CG + C SG H + G+ C +C G+ + C T LC
Sbjct: 68 -KSKCG----------PTFFPCASGIHCIIGRFRCNGFEDC-PDGSDEENC--TANPLLC 113
Query: 3848 SCARNFMK 3855
S AR K
Sbjct: 114 STARYHCK 121
Score = 50.1 bits (118), Expect = 5e-05
Identities = 37/139 (26%), Positives = 51/139 (36%), Gaps = 44/139 (31%)
Query: 2902 HKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKI 2961
++CN F+CS+GRC+ A C+G DC D SDE+ C
Sbjct: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECP--------------------- 65
Query: 2962 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 3021
K +C P F FPC+ G ++C E P G D +C
Sbjct: 66 KAKSKCGPTF------------------FPCASGIHCIIGRFRCNGFED-CPDGSDEENC 106
Query: 3022 KAVTDEEPFLIFANRYYLR 3040
A P L RY+ +
Sbjct: 107 TA----NPLLCSTARYHCK 121
Score = 49.7 bits (117), Expect = 7e-05
Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 5/113 (4%)
Query: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQ 855
D ++ +KC C+S G +C ED +D C ANP C
Sbjct: 60 DEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL-----CS 114
Query: 856 PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCI 908
+ C N CI + + CDG N+C DNSDE Q F N+ +
Sbjct: 115 TARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 112 bits (279), Expect = 1e-23
Identities = 91/282 (32%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 4148 TNPCDRKKCEW-LCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQ-CF 4205
++PC + C +C +P G C C + G P S + DA C Q C
Sbjct: 696 SHPCAHEPCSHGICYDAPGGFRCVC------EPGWSGPRCSQSLARDA-----CESQPCR 744
Query: 4206 NGGSCFLNARRQPKCRCQPRYTGDKCEL-DQCWEH-CRNGGTCAASPSGMPTCRCPTGFT 4263
GG+C + C C P G +CEL C + C +GG C ++P +P C CP G+
Sbjct: 745 AGGTCSSDGMGF-HCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ 803
Query: 4264 GPKCTQQV--CAG--YCANNSTCTVNQGNQPQCRCLPGFLGDRC--QYRQCS-GYCENFG 4316
GP+C Q V CAG C + CT N C C G+ G C C C N G
Sbjct: 804 GPRCQQDVDECAGPAPCGPHGICT-NLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862
Query: 4317 TCQMAADGSRQCRCTAYFEGSRC--EVNKC--SRCLEGACVVNKQSGDVTCNCTDGRVAP 4372
+CQ GS C C F G RC +V++C + C G C + S TC C G
Sbjct: 863 SCQDGV-GSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVAS--FTCTCPPGYGGF 919
Query: 4373 SCLTCVGHCS-----NGGSCTMNSKMMPECQCPPHMTGPRCE 4409
C + CS NGG+C C C P TG C+
Sbjct: 920 HCEQDLPDCSPSSCFNGGTCVDGVNSF-SCLCRPGYTGAHCQ 960
Score = 104 bits (260), Expect = 2e-21
Identities = 87/311 (27%), Positives = 116/311 (37%), Gaps = 74/311 (23%)
Query: 4174 GKRLDNGTCVPVPSPTP------------PPDAPRPGTCNLQCFNGGSCFLNARRQPKCR 4221
G+R P P P P P A P C NGG C R+ C
Sbjct: 7 GRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACL 66
Query: 4222 CQPRYTGDKCEL-DQCWEH-CRNGGTCAASP---SGMPTCRCPTGFTGPKCT--QQVCAG 4274
C P + G++C+L D C C G C +S + +CRCP GF GP C+ +
Sbjct: 67 CPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSS 126
Query: 4275 YCANNSTCTVNQGNQPQCRCLPGFLGDRCQ------------------------YR-QC- 4308
CA+ + C+V + C C PG+ G C+ +R QC
Sbjct: 127 PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCP 186
Query: 4309 SGY----------------CENFGTCQMAADGSRQCRCTAYFEGSRCEVN--KC--SRCL 4348
+GY C N GTC+ + D + C C FEG CEVN C RCL
Sbjct: 187 AGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCL 246
Query: 4349 EGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCS-------NGGSCTMNSKMMPECQCPP 4401
G V+ + C C C V C NGG+C N+ C C
Sbjct: 247 NGGTCVDGVN-TYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTC-FNTLGGHSCVCVN 304
Query: 4402 HMTGPRCEEHV 4412
TG C +++
Sbjct: 305 GWTGESCSQNI 315
Score = 100 bits (249), Expect = 3e-20
Identities = 99/330 (30%), Positives = 128/330 (38%), Gaps = 67/330 (20%)
Query: 4141 QHKQPEVTNPCDRKKCEW--LCLLSPSG-PVCTCPNGKRLDNGTCVPVPSPTPPPDAPRP 4197
Q +Q E+ +PC CE C +P PVC+CP G + P P P
Sbjct: 765 QGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHG 824
Query: 4198 GTCNLQ---------------------------CFNGGSCFLNARRQPKCRCQPRYTGDK 4230
NL C NGGSC + C C P + G +
Sbjct: 825 ICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPR 883
Query: 4231 C--ELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQV--CA-GYCANNSTCTVN 4285
C ++D+C + GTC + TC CP G+ G C Q + C+ C N TC V+
Sbjct: 884 CARDVDECLSNPCGPGTCTDHVASF-TCTCPPGYGGFHCEQDLPDCSPSSCFNGGTC-VD 941
Query: 4286 QGNQPQCRCLPGFLGDRCQYRQ---CSGYCENFGTCQMAADGSRQCRCTAYFEGSRCE-- 4340
N C C PG+ G CQ+ S C + G C A G R C C F G +C+
Sbjct: 942 GVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFR-CTCLESFTGPQCQTL 1000
Query: 4341 VNKCSR--CLEGA-CVVNKQSGDVTCNCTDGRVAPSC----LTC------VG-----HCS 4382
V+ CSR C G CV Q+G C C G C L C +G C
Sbjct: 1001 VDWCSRQPCQNGGRCV---QTG-AYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQ 1056
Query: 4383 NGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
GG C ++ C CP TG CE+ V
Sbjct: 1057 AGGQC-VDEDSSHYCVCPEGRTGSHCEQEV 1085
Score = 95.1 bits (235), Expect = 1e-18
Identities = 84/278 (30%), Positives = 114/278 (41%), Gaps = 34/278 (12%)
Query: 4160 CLLSPSGPVCTCPNG----KRLDNGTCVPVPSPTPPPDAPRPGTC-NLQCFNGGSCFLNA 4214
C L P+ C NG L +CV V T + C CF+G +C +
Sbjct: 278 CQLQPNA----CHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCH-DR 332
Query: 4215 RRQPKCRCQPRYTGDKCELDQCW--EHCRNGGTCAASP-SGMPTCRCPTGFTGPKCTQQV 4271
C C TG C LD C C +P +G C CP GFTG C Q V
Sbjct: 333 VASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDV 392
Query: 4272 --C---AGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQC-SGYCENFGTCQMAAD 4323
C A C + C QG+ C+C G+ G RC+ +C SG C N TC +
Sbjct: 393 DECSIGANPCEHLGRCVNTQGSF-LCQCGRGYTGPRCETDVNECLSGPCRNQATC-LDRI 450
Query: 4324 GSRQCRCTAYFEGSRCEVN----KCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVG 4379
G C C A F G+ CEV+ + S C+ G ++ +G +C C G +C V
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNG-FSCTCPSGFSGSTCQLDVD 509
Query: 4380 HCS-----NGGSCTMNSKMMPECQCPPHMTGPRCEEHV 4412
C+ NG C ++ EC+C G C+ +V
Sbjct: 510 ECASTPCRNGAKC-VDQPDGYECRCAEGFEGTLCDRNV 546
Score = 87.0 bits (214), Expect = 4e-16
Identities = 84/306 (27%), Positives = 109/306 (35%), Gaps = 69/306 (22%)
Query: 4160 CLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPK 4219
C+ P G C C G GT PD G +C +G + F
Sbjct: 522 CVDQPDGYECRCAEGFE---GTLCDRNVDDCSPDPCHHG----RCVDGIASF-------S 567
Query: 4220 CRCQPRYTGDKCE--LDQCWEH-CRNGGTC---------------------------AAS 4249
C C P YTG +CE +D+C CR+GG C A++
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
Query: 4250 PSGMPTCR---------CPTGFTGPKCTQQV--CAGY-CANNSTCTVNQGNQPQCRCLPG 4297
P CR C GFTGP C ++ CA C +C V+ N +C C PG
Sbjct: 628 PCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSC-VDGENGFRCLCPPG 686
Query: 4298 FLGDRC--QYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLE------ 4349
L C C+ + G C A G R C C + G RC + E
Sbjct: 687 SLPPLCLPPSHPCAHEPCSHGICYDAPGGFR-CVCEPGWSGPRCSQSLARDACESQPCRA 745
Query: 4350 -GACVVNKQSGDVTCNC-TDGRVAPSCLTCVGH-CSNGGSCTMNSKMMPECQCPPHMTGP 4406
G C + TC GR C + C +GG C +P C CP GP
Sbjct: 746 GGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGP 805
Query: 4407 RCEEHV 4412
RC++ V
Sbjct: 806 RCQQDV 811
Score = 86.7 bits (213), Expect = 5e-16
Identities = 91/335 (27%), Positives = 119/335 (35%), Gaps = 101/335 (30%)
Query: 4160 CLLSPSGP----------VCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGS 4209
CL +P GP CTCP G G P P + CFNGG+
Sbjct: 891 CLSNPCGPGTCTDHVASFTCTCPPGY---GGFHCEQDLPDCSPSS---------CFNGGT 938
Query: 4210 CFLNARRQPKCRCQPRYTGDKC--ELDQCWEH-CRNGGTCAASPSGMPTCRCPTGFTGPK 4266
C ++ C C+P YTG C E D C C +GG C+A+ G C C FTGP+
Sbjct: 939 C-VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGF-RCTCLESFTGPQ 996
Query: 4267 CTQQV--CAGY-CANNSTCTVNQGNQPQCRCLPGFLGDRCQYR----------------- 4306
C V C+ C N C V G C C PG+ G C R
Sbjct: 997 CQTLVDWCSRQPCQNGGRC-VQTG--AYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQ 1053
Query: 4307 ------QC-----SGYC-----------------------ENFGTCQMAADGSRQCRCTA 4332
QC S YC ++ GTC+ G C C
Sbjct: 1054 LCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCR-GYMGGYMCECLP 1112
Query: 4333 YFEGSRCE--VNKCSR--CLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCS------ 4382
+ G CE V++C+ C G ++ + + C+C G + C C
Sbjct: 1113 GYNGDNCEDDVDECASQPCQHGGSCIDLVARYL-CSCPPGTLGVLCEINEDDCGPGPPLD 1171
Query: 4383 NGGSCTMNSKMMP-----ECQCPPHMTGPRCEEHV 4412
+G C N + C CPP TG RCE +
Sbjct: 1172 SGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADI 1206
Score = 84.7 bits (208), Expect = 2e-15
Identities = 86/309 (27%), Positives = 115/309 (37%), Gaps = 63/309 (20%)
Query: 4142 HKQPEVTNPCDRKKC--EWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGT 4199
H Q E +PC + C +C + G CTC + S T P
Sbjct: 958 HCQHEA-DPCLSRPCLHGGVCSAAHPGFRCTC-------------LESFTGPQCQTLVDW 1003
Query: 4200 CNLQ-CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQ--CWEH-----------CRNGGT 4245
C+ Q C NGG C + C C P ++G C++ C E C+ GG
Sbjct: 1004 CSRQPCQNGGRC---VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQ 1060
Query: 4246 CAASPSGMPTCRCPTGFTGPKCTQQV---CAGYCANNSTCTVNQGNQPQCRCLPGFLGDR 4302
C S C CP G TG C Q+V A C + TC G C CLPG+ GD
Sbjct: 1061 CVDEDSSH-YCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGY-MCECLPGYNGDN 1118
Query: 4303 CQ--YRQCSGY-CENFGTCQMAADGSRQCRCTAYFEGSRCEVNK--CS---------RCL 4348
C+ +C+ C++ G+C + C C G CE+N+ C RCL
Sbjct: 1119 CEDDVDECASQPCQHGGSC-IDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCL 1177
Query: 4349 -EGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGG-------SCTMNSKMMPECQCP 4400
G CV G C C G C + C +G C + C C
Sbjct: 1178 HNGTCV--DLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH 1235
Query: 4401 PHMTGPRCE 4409
+GPRC+
Sbjct: 1236 AGFSGPRCQ 1244
Score = 79.0 bits (193), Expect = 1e-13
Identities = 60/211 (28%), Positives = 82/211 (38%), Gaps = 21/211 (9%)
Query: 4220 CRCQPRYTGDKC--ELDQCWEH-CRNGGTCAASPSGMPTCRCPTGFTGPKCT--QQVCAG 4274
C CQP +TG C E+++C C GG+C +G C CP G P C CA
Sbjct: 643 CVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF-RCLCPPGSLPPLCLPPSHPCAH 701
Query: 4275 YCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENF-----GTCQMAADGSRQCR 4329
++ C G +C C PG+ G RC CE+ GTC G C
Sbjct: 702 EPCSHGICYDAPGGF-RCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFH-CT 759
Query: 4330 CTAYFEGSRCEV-NKCSR--CLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGS 4386
C +G +CE+ + C+ C G + C+C G P C V C+
Sbjct: 760 CPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAP 819
Query: 4387 C-----TMNSKMMPECQCPPHMTGPRCEEHV 4412
C N C C TGP C++ +
Sbjct: 820 CGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Score = 75.5 bits (184), Expect = 1e-12
Identities = 76/266 (28%), Positives = 98/266 (36%), Gaps = 61/266 (22%)
Query: 4168 VCTCPNGK-----RLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRC 4222
+C+CP G ++ C P P P PR C + G+C ++ +C C
Sbjct: 1145 LCSCPPGTLGVLCEINEDDCGPGP---PLDSGPR-------CLHNGTC-VDLVGGFRCTC 1193
Query: 4223 QPRYTGDKCELDQCWEHCRNGGT-------CAASPSGMPTCRCPTGFTGPKCTQQV--CA 4273
P YTG +CE D CR+G C P G C C GF+GP+C + C
Sbjct: 1194 PPGYTGLRCEADI--NECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCE 1251
Query: 4274 GY-CANNSTCTVNQGNQP----QCRCLPGFLGDRCQ--YRQCSG-YCENFGTCQMAADGS 4325
C + C + G C C F G RC+ R C C CQ G
Sbjct: 1252 SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGP 1311
Query: 4326 RQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGG 4385
R C C G C R G+ G +C AP C +GG
Sbjct: 1312 R-CACPPGLSGPSC------RSFPGS-----PPGASNASCA---AAP--------CLHGG 1348
Query: 4386 SCTMNSKMMP--ECQCPPHMTGPRCE 4409
SC + + P C C TGPRCE
Sbjct: 1349 SC-RPAPLAPFFRCACAQGWTGPRCE 1373
Score = 70.9 bits (172), Expect = 3e-11
Identities = 154/664 (23%), Positives = 216/664 (32%), Gaps = 172/664 (25%)
Query: 3293 PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNC--------------TASQ 3338
PC + C + P G C+CP Y G R+ V C T
Sbjct: 122 PCLSSPCAHGARCSVGPDGRFLCSCPPG-YQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180
Query: 3339 F-----------VCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQ---CS 3382
F +C+N C P C C D DC C PG F+ C
Sbjct: 181 FRCQCPAGYTGPLCENPAVPCAPS--PCRNGGTCRQSGDLTYDCA---CLPG-FEGQNCE 234
Query: 3383 TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDG 3442
+ P C C D + NC QF + + C C+ C +
Sbjct: 235 VNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNT 294
Query: 3443 EDERDCPEV------TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE-----PANCTQ 3491
C V +C+ N C+ VC C D P T
Sbjct: 295 LGGHSCVCVNGWTGESCSQNIDDCATA--------VCFHGATCHDRVASFYCACPMGKTG 346
Query: 3492 MTCGVDEF----RCKDSGRC----IPARWKCDGEDD-CGDGSDEPKEECD--ERTCEPYQ 3540
+ C +D+ C + C + R C G D+ +EC CE +
Sbjct: 347 LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCE-HL 405
Query: 3541 FRCKNNR----CVPGRW----QCDYD-NDC--GDNSDEESCTPRPCSESEFSCANGRCIA 3589
RC N + C GR +C+ D N+C G ++ +C R +F+C C+A
Sbjct: 406 GRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDR---IGQFTCI---CMA 459
Query: 3590 GRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC-- 3647
G G + C++D +C+S C+ C D + +C
Sbjct: 460 G---FTGTY--------------CEVDIDECQSSPCV-------NGGVCKDRVNGFSCTC 495
Query: 3648 --GTGVRTCPLDEFQCNNTLCKPLAWKCDGED--DC-------GDNSDENPEECARFVCP 3696
G TC LD +C +T C+ A D D +C G D N ++C+ C
Sbjct: 496 PSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH 555
Query: 3697 PNR------PFRCKNDRVCL--WIGRQCDG-TDNCGDGTDEEDCEPPTAHTTHCKD-KKE 3746
R F C C + G +C+ D C P H C D +
Sbjct: 556 HGRCVDGIASFSC----ACAPGYTGTRCESQVDECR--------SQPCRHGGKCLDLVDK 603
Query: 3747 FLCRNQRCLSSSLRCNM---FDDCG----------DGSDEEDCSIDPKLTSCATNASI-- 3791
+LC RC S + N DDC DG + DC P T N I
Sbjct: 604 YLC---RCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINE 660
Query: 3792 -----CGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQ-LCNNTKGGH 3845
CG+ CV E C C G ++P P C + CS +C + GG
Sbjct: 661 CASSPCGEGGSCVDGENGFRCLCPPG--SLP--PLCLPPSHPCAHEPCSHGICYDAPGGF 716
Query: 3846 LCSC 3849
C C
Sbjct: 717 RCVC 720
Score = 69.7 bits (169), Expect = 6e-11
Identities = 136/542 (25%), Positives = 173/542 (31%), Gaps = 165/542 (30%)
Query: 2563 SRRCKKTFR--------QCSNGRCVSNMLWCNGAD-----DCGDGSDEIPCNKTA--CGV 2607
S RC + FR C + C G D C G C C V
Sbjct: 105 SCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV 164
Query: 2608 GEFRCRDGTCIGN--SSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSL 2665
GE GTC+ S RC C A G G L CE ++
Sbjct: 165 GEPCRHGGTCLNTPGSFRCQ-------------CPA---------GYTGPL---CENPAV 199
Query: 2666 CYAPSWVCDGANDC---GDYSDERDC-PGVKRPRCPLNYFACPSGRCIPMSWTCDKED-- 2719
APS C C GD + + C PG + C +N CP RC+ D +
Sbjct: 200 PCAPS-PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258
Query: 2720 DCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSF 2779
+C+ + T +FC+E ECQ A H G TC F
Sbjct: 259 NCQCPPEWT--GQFCTEDVDECQLQ-------------------PNACH-NGGTC----F 292
Query: 2780 SCPGTHVCV-PERWLCDGDKDCADGADESIAAGCLYNSTCDDR--EFMCQNRQCIPKHFV 2836
+ G H CV W + C+ D+ A C + +TC DR F C +
Sbjct: 293 NTLGGHSCVCVNGWT---GESCSQNIDDCATAVCFHGATCHDRVASFYCACPMG-KTGLL 348
Query: 2837 CDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPH 2896
C D C +P E C + NGR + + G C DE +
Sbjct: 349 CHLDDACVS----NPCHEDAICDTNP---VNGRAICTCPPGFTG-GACDQDVDECSIGAN 400
Query: 2897 CTSQEHKC-NASSQFLCSSGR------C---VAEALL--CNGQDDCGDSSDERGC----- 2939
+C N FLC GR C V E L C Q C D + C
Sbjct: 401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAG 460
Query: 2940 --------HINECLSRKLSGCSQD--CEDLKIGFKCRCRPGFRLKDDGRTCA-DVDECST 2988
I+EC S S C C+D GF C C GF G TC DVDEC++
Sbjct: 461 FTGTYCEVDIDECQS---SPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECAS 513
Query: 2989 TFPCSQ---------------------------------------RCINTHGSYKCLCVE 3009
T PC RC++ S+ C C
Sbjct: 514 T-PCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAP 572
Query: 3010 GY 3011
GY
Sbjct: 573 GY 574
Score = 69.3 bits (168), Expect = 8e-11
Identities = 132/592 (22%), Positives = 194/592 (32%), Gaps = 148/592 (25%)
Query: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFE 2531
N C SPCR N G C+ LT+ +C+C G +C + +
Sbjct: 196 NPAVPCAPSPCR-NGGTCRQSGDLTY----DCACLPG----------FEGQNCEVNVD-D 239
Query: 2532 CANGECINFSLTCDGVP--HCKDKSDEKPSYCNSR--RCKKTFRQCSNGRCVSNML---- 2583
C C+N DGV +C+ + +C C+ C NG N L
Sbjct: 240 CPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
Query: 2584 ------WCNGA-----DDCGDG--------SDEIPCNKTACGVGE--FRCR-DGTCIGNS 2621
W + DDC D + AC +G+ C D C+ N
Sbjct: 300 CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP 359
Query: 2622 SRCNQFVDCEDASDEMNCSATDCSSYFRLGVK-------GVLFQPCERTSLCYAP--SWV 2672
+ D + C+ C F G + PCE C S++
Sbjct: 360 CHEDAICDTNPVNGRAICT---CPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFL 416
Query: 2673 CDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDD----CEHGEDET 2728
C CG G PRC + C SG C + D+ C G T
Sbjct: 417 CQ----CGR--------GYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGT 464
Query: 2729 HCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCV 2788
+C E CQ+ C++ G + + TC PS FS
Sbjct: 465 YCEVDIDE----CQSSPCVN-----------GGVCKDRVNGFSCTC-PSGFS-------- 500
Query: 2789 PERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSD 2848
C DE + C + C D+ P + C CA+G
Sbjct: 501 --------GSTCQLDVDECASTPCRNGAKCVDQ----------PDGYECR----CAEGF- 537
Query: 2849 ESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASS 2908
E C+ S C +GRC+ DG C SQ +C S
Sbjct: 538 EGTLCDRNVDDCSPDPCHHGRCV-------DGIASFSCACAPGYTGTRCESQVDECR--S 588
Query: 2909 QFLCSSGRCV--AEALLCNGQDDCGDSSDERGCHIN--ECLSRKLSGCSQDCEDLKIGFK 2964
Q G+C+ + LC C + C +N +C S + C D +
Sbjct: 589 QPCRHGGKCLDLVDKYLCR----CPSGTTGVNCEVNIDDCASNPCT--FGVCRDGINRYD 642
Query: 2965 CRCRPGFRLKDDGRTC-ADVDECSTTFPCSQ--RCINTHGSYKCLCVEGYAP 3013
C C+PGF G C +++EC+++ PC + C++ ++CLC G P
Sbjct: 643 CVCQPGFT----GPLCNVEINECASS-PCGEGGSCVDGENGFRCLCPPGSLP 689
Score = 62.4 bits (150), Expect = 1e-08
Identities = 145/610 (23%), Positives = 201/610 (32%), Gaps = 137/610 (22%)
Query: 2474 TNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGG----RILQDDLTCRAVNSSCRAQDE 2529
++ C PC ++G C D G C C G R Q + CRA
Sbjct: 696 SHPCAHEPC--SHGICYDA-----PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGT 748
Query: 2530 FECANGECINFSLTCD-GVP--HCKDKSDEKPSYC-NSRRCKKTFRQ-----CSNG---- 2576
+ + + F TC GV C+ S P+ C + RC+ Q C G
Sbjct: 749 ---CSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGP 805
Query: 2577 RCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS--RCNQFVD----- 2629
RC ++ C G CG C A G F C TC G + C+Q ++
Sbjct: 806 RCQQDVDECAGPAPCGPHGI---CTNLA---GSFSC---TCHGGYTGPSCDQDINDCDPN 856
Query: 2630 -------CEDASDEMNCSATDCSSYFRLG--VKGVLFQPC-ERTSLCYAPSWVCDGANDC 2679
C+D +CS + R V L PC T + S+ C
Sbjct: 857 PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY 916
Query: 2680 GDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQF 2739
G + E+D P C N C G S++C C G HC
Sbjct: 917 GGFHCEQDLPDCSPSSC-FNGGTCVDG---VNSFSCL----CRPGYTGAHCQH------- 961
Query: 2740 ECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVP--ERWLCDGD 2797
+ C+S+ L G C AAH + SF+ P V R C
Sbjct: 962 --EADPCLSRPCLHGGV--CS-----AAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNG 1012
Query: 2798 KDCADGADESIAAGCLYNSTCDDREFMCQNRQC---IPKHFVCDHDRDCADGSDESPECE 2854
C + CD R C+ + +C C D D S C
Sbjct: 1013 GRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVD-EDSSHYCV 1071
Query: 2855 YPTCGPSEFRCAN-------------GRC---LSSRQWEC----DGENDCHDQSDEAPKN 2894
P G + C G C + EC +G+N C D DE
Sbjct: 1072 CPE-GRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDN-CEDDVDECASQ 1129
Query: 2895 PHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDS----SDERGCHINECLSRKLS 2950
P C + +++LCS L +DDCG S R H C+
Sbjct: 1130 P-CQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCV----- 1183
Query: 2951 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC-ADVDECST-------TFPCSQRCINTHGS 3002
DL GF+C C PG+ G C AD++EC + T C Q + G
Sbjct: 1184 -------DLVGGFRCTCPPGY----TGLRCEADINECRSGACHAAHTRDCLQ---DPGGG 1229
Query: 3003 YKCLCVEGYA 3012
++CLC G++
Sbjct: 1230 FRCLCHAGFS 1239
Score = 58.2 bits (139), Expect = 2e-07
Identities = 112/492 (22%), Positives = 155/492 (31%), Gaps = 162/492 (32%)
Query: 3479 CVDGSD--EPANCTQMTCGVDEFRCKDSGRCIPARW---KCDGEDDCGDGSDEPKEECDE 3533
C+DGS CTQ+ +++ P W +C ED C G + C
Sbjct: 43 CLDGSPCANGGRCTQLPS-------REAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQS 95
Query: 3534 RTCE-PYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG-RCIAG- 3590
+F C+ R G DC P PC S CA+G RC G
Sbjct: 96 SVVAGTARFSCRCPRGFRGP-------DCS--------LPDPCLSSP--CAHGARCSVGP 138
Query: 3591 --RWKCDGDHDCADGSDEKDCTPRCDMDQFQ----CK-SGHCI--PLRWRCDA------- 3634
R+ C C G + C R D+D+ + C+ G C+ P +RC
Sbjct: 139 DGRFLCS----CPPGYQGRSC--RSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGP 192
Query: 3635 ----------------------------DADCMDGSDEEACGTGVRTCP----------L 3656
D C+ G + + C V CP +
Sbjct: 193 LCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCV 252
Query: 3657 DEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCL------ 3710
D N C P W G E+ +EC +P C N C
Sbjct: 253 DGVNTYNCQCPP-EWT-------GQFCTEDVDECQL------QPNACHNGGTCFNTLGGH 298
Query: 3711 -------WIGRQCDGTDNCGDGTDEEDCEPPTA-HTTHCKDK-KEFLCRNQRCLSSSLRC 3761
W G C + +DC H C D+ F C + L C
Sbjct: 299 SCVCVNGWTGESCS--------QNIDDCATAVCFHGATCHDRVASFYCACPMG-KTGLLC 349
Query: 3762 NMFDDCGDGSDEED-------------CSIDPKLTS---------CATNASICGDEARCV 3799
++ D C ED C+ P T C+ A+ C RCV
Sbjct: 350 HLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV 409
Query: 3800 RTEKAAYCACRSGFHTVPGQPGCQ-DINECLRFGTC--SQLCNNTKGGHLCSCARNFMKT 3856
T+ + C C G+ P C+ D+NECL G C C + G C C F T
Sbjct: 410 NTQGSFLCQCGRGY----TGPRCETDVNECLS-GPCRNQATCLDRIGQFTCICMAGFTGT 464
Query: 3857 HNTCKAEGSEYQ 3868
+ C+ + E Q
Sbjct: 465 Y--CEVDIDECQ 474
Score = 57.8 bits (138), Expect = 2e-07
Identities = 153/698 (21%), Positives = 211/698 (30%), Gaps = 205/698 (29%)
Query: 3293 PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC---VSNCTASQFVCKND-KCI- 3347
PC VN G C + G C CP+ F G TC V C ++ C+N KC+
Sbjct: 477 PC-VNGGVCKDRV-----NGFSCTCPSGF----SGSTCQLDVDECASTP--CRNGAKCVD 524
Query: 3348 -PFWWKCDTEDD-----CGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQD 3401
P ++C + C + D DC C G+ C GI + G +
Sbjct: 525 QPDGYECRCAEGFEGTLCDRNVD---DCSPDPCHHGR--CVDGIASFSCACAPGYTGTRC 579
Query: 3402 NSDEANCDIHVC--------LPSQFKCTNTNRCIPGIFRCNGQDN-------------CG 3440
S C C L ++ C RC G N + N C
Sbjct: 580 ESQVDECRSQPCRHGGKCLDLVDKYLC----RCPSGTTGVNCEVNIDDCASNPCTFGVCR 635
Query: 3441 DGEDERDCPEVTCAPNQFQ--CSIT-KRCIPRVWVCDRDNDCVDGSDE-----PANCTQM 3492
DG + DC C P C++ C C CVDG + P
Sbjct: 636 DGINRYDC---VCQPGFTGPLCNVEINECASSP--CGEGGSCVDGENGFRCLCPPGSLPP 690
Query: 3493 TCGVDEFRCKDS----GRCI--PARWKCDGEDDCGDGSDEPK-------EECDERTC--- 3536
C C G C P ++C C G P+ + C+ + C
Sbjct: 691 LCLPPSHPCAHEPCSHGICYDAPGGFRCV----CEPGWSGPRCSQSLARDACESQPCRAG 746
Query: 3537 -----EPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEES--CTPRPCSESEFSCANG---- 3585
+ F C V GR QC+ + C N E C P SC G
Sbjct: 747 GTCSSDGMGFHCTCPPGVQGR-QCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGP 805
Query: 3586 RC------IAGRWKCDGDHDCADGSDEKDCT-------PRCDMDQFQCKSGHCIPLRWRC 3632
RC AG C C + + CT P CD D C C+
Sbjct: 806 RCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLN----- 860
Query: 3633 DADADCMDGSDEEAC----GTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPE 3688
C DG +C G C D +C + C P C D+
Sbjct: 861 --GGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP--------GTCTDH------ 904
Query: 3689 ECARFVC---PPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHT-THCKDK 3744
A F C P F C+ D C C DG + C +T HC+ +
Sbjct: 905 -VASFTCTCPPGYGGFHCEQDLPDC-SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962
Query: 3745 KEFLCRNQRCLSSSL--------RCNMFDD------------------------------ 3766
+ C ++ CL + RC +
Sbjct: 963 AD-PCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021
Query: 3767 --CGDGSDEEDCSIDPKLTSCATNAS--------ICGDEARCVRTEKAAYCAC---RSGF 3813
C G C I + C A+ +C +CV + + YC C R+G
Sbjct: 1022 CLCPPGWSGRLCDI--RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGS 1079
Query: 3814 HTVPGQPGCQDINECLRFGTCSQ--LCNNTKGGHLCSC 3849
H Q+++ CL C C GG++C C
Sbjct: 1080 HCE------QEVDPCLA-QPCQHGGTCRGYMGGYMCEC 1110
Score = 57.4 bits (137), Expect = 3e-07
Identities = 73/290 (25%), Positives = 97/290 (33%), Gaps = 74/290 (25%)
Query: 4159 LCLLSPSGPVCT-----CPNGKRLDNGTCVPVPSP----------TPPPDAPR----PGT 4199
LC SGP C C + G C P P P P PR +
Sbjct: 1233 LCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARS 1292
Query: 4200 CN-LQCFNGGSCFLNARRQPKCRCQPRYTGDKCE-----------LDQCWEHCRNGGTCA 4247
C LQC G C R P+C C P +G C C +GG+C
Sbjct: 1293 CRELQCPVGVPC-QQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCR 1351
Query: 4248 ASP-SGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYR 4306
+P + C C G+TGP+C A + C P+ C RC R
Sbjct: 1352 PAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRC-------PRAACQAKRGDQRCD-R 1403
Query: 4307 QCS--GYCENFGTCQMA-ADGSRQC---RCTAYFEGSRCEVNKCSRCLEGACVVNKQSGD 4360
+C+ G + G C ++ D RQC +C F SRC D
Sbjct: 1404 ECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRC--------------------D 1443
Query: 4361 VTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEE 4410
C+ +P+CL C GG + E C H RC++
Sbjct: 1444 PACS------SPACLYDNFDCHAGGR-ERTCNPVYEKYCADHFADGRCDQ 1486
Score = 57.0 bits (136), Expect = 4e-07
Identities = 143/608 (23%), Positives = 194/608 (31%), Gaps = 177/608 (29%)
Query: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAE-------DQVLDA-------DGVT 841
D + Q+ N C +NGG C T G C C Q +D G T
Sbjct: 274 DVDECQLQPNAC--HNGGT---CFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGAT 328
Query: 842 CLANPS--YVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSD- 898
C + Y P + G + C+ C D C N A+C TCP
Sbjct: 329 CHDRVASFYCACPMGKTGLLCHLDDACVSN--PCHEDAICDTNPVNGRAIC---TCPPGF 383
Query: 899 ---------------RFKCEN-NRCIPNRWL-------------CDGD-NDCGNSEDESN 928
CE+ RC+ + C+ D N+C + +
Sbjct: 384 TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ 443
Query: 929 ATCSARTCPPNQFSCASGRCIPISWTCDLDDD------------CGDRSDESASCAYPTC 976
ATC R QF+C ++ C++D D C DR + SC P+
Sbjct: 444 ATCLDRI---GQFTCICMAGFTGTY-CEVDIDECQSSPCVNGGVCKDRVN-GFSCTCPSG 498
Query: 977 FPLTQFTCNNGRCININWRCDNDNDCGDNSD--EAGCSHSCSSTQFKCNSGRCIPE---H 1031
F + + C + C N C D D E C+ T N C P+ H
Sbjct: 499 FSGSTCQLDVDECASTP--CRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHH 556
Query: 1032 WTC-DG--DNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPL----RWRCDG 1084
C DG C T C +Q C + CR G C+ L RC
Sbjct: 557 GRCVDGIASFSCACAPGYTGTRCESQVDE----CRSQP--CRHGGKCLDLVDKYLCRCPS 610
Query: 1085 DT---DC---MDSSDEKSC------EGVTH---VCDP-------SVKFGCKDSARCISKA 1122
T +C +D C +G+ VC P +V+ S+ C
Sbjct: 611 GTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGG 670
Query: 1123 WVCDGDNDCEDNSDEENCESLACRPPSHPCANNTS--------------VCLP------- 1161
DG+N + L C PPSHPCA+ VC P
Sbjct: 671 SCVDGENGFRCLCPPGSLPPL-CLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRC 729
Query: 1162 ---------PDKLCDGNDDCG-DGSD------------EGELCDQCSLNNGGCSHN--CS 1197
+ C C DG + EL C+ N C H C
Sbjct: 730 SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP--CEHGGRCE 787
Query: 1198 VAPGEGIVCSCPLGMELGP----DNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWV 1253
APG+ VCSCP G + GP D C + C H C+ S C+C+ G+
Sbjct: 788 SAPGQLPVCSCPQGWQ-GPRCQQDVDECAGPAPCGPHGICTNLAG----SFSCTCHGGYT 842
Query: 1254 LEPDGESC 1261
G SC
Sbjct: 843 ----GPSC 846
Score = 55.1 bits (131), Expect = 2e-06
Identities = 98/411 (23%), Positives = 128/411 (31%), Gaps = 111/411 (27%)
Query: 2689 PGVKRPRCPLNYFACPSGRCI-----------PMSWT---CDKEDDCEHG----EDETHC 2730
PG P C GRC P W C ED C G
Sbjct: 36 PGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQS 95
Query: 2731 NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSS---FSCPGTHVC 2787
+ A+F C+ R C D C S AH + GP SCP +
Sbjct: 96 SVVAGTARFSCRCPRGFRGPD-CSLPDPCL--SSPCAHGARCSVGPDGRFLCSCPPGYQ- 151
Query: 2788 VPERWLCDGDKDCADGADES-IAAGCLYNSTCDDR--EFMCQNRQ-------------CI 2831
+ C DE + C + TC + F CQ C
Sbjct: 152 ---------GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCA 202
Query: 2832 PKHFVCDHDRDCADGSDESPEC------EYPTCGPSEFRCANGRCLSSRQWECDGENDCH 2885
P C + C D + +C E C + C RCL+ DG N +
Sbjct: 203 PSP--CRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTC-VDGVNTYN 259
Query: 2886 DQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCV----AEALLC-NGQ---------DDCG 2931
Q CT +C + G C + +C NG DDC
Sbjct: 260 CQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCA 319
Query: 2932 DSSDERG----------------------CHINE-CLSRKLSGCSQD--CEDLKIGFK-- 2964
+ G CH+++ C+S C +D C+ + +
Sbjct: 320 TAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNP---CHEDAICDTNPVNGRAI 376
Query: 2965 CRCRPGFRLKDDGRTC-ADVDECST-TFPCSQ--RCINTHGSYKCLCVEGY 3011
C C PGF G C DVDECS PC RC+NT GS+ C C GY
Sbjct: 377 CTCPPGFT----GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
Score = 51.6 bits (122), Expect = 2e-05
Identities = 63/191 (32%), Positives = 75/191 (39%), Gaps = 37/191 (19%)
Query: 4 PPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEI 63
PP + LPLL L AP C D C + G RC P S EA +
Sbjct: 21 PPPVRALPLLLLLAGPGAAAPP--------CLDGSPC-ANGGRCT---QLP--SREAACL 66
Query: 64 CPQS-KAQRCQPNE--HN--CLGTELCVPMSRLCNGVQD----CMDGSDEGPHCRELQGN 114
CP +RCQ + H+ C G +C S + G C G GP C L
Sbjct: 67 CPPGWVGERCQLEDPCHSGPCAGRGVC--QSSVVAGTARFSCRCPRGF-RGPDC-SLPDP 122
Query: 115 CSRLGCQH--HCVPTLDGP-TCYCNSSFQLQADGKTCK-DFDECSVYGTCSQ--LCTNTD 168
C C H C DG C C +Q G++C+ D DEC V C C NT
Sbjct: 123 CLSSPCAHGARCSVGPDGRFLCSCPPGYQ----GRSCRSDVDECRVGEPCRHGGTCLNTP 178
Query: 169 GSFICGCVEGY 179
GSF C C GY
Sbjct: 179 GSFRCQCPAGY 189
Score = 47.4 bits (111), Expect = 3e-04
Identities = 117/478 (24%), Positives = 154/478 (32%), Gaps = 125/478 (26%)
Query: 795 YDAQQQQVGTNKCRVN----NGGCSSLCLATPGSRQCAC--------AEDQVLDA----- 837
Y + + ++CRV +GG CL TPGS +C C E+ +
Sbjct: 150 YQGRSCRSDVDECRVGEPCRHGGT---CLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPC 206
Query: 838 -DGVTCLANPSYVPPPQCQPGEFA---------CANSRCIQERWKCDGDND--------- 878
+G TC + C PG C RC+ DG N
Sbjct: 207 RNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEW 266
Query: 879 ----CLDNSDEA---PALCHQHTCPSDRFKCENNRCIPNRWL---CDGD-NDCGNSEDES 927
C ++ DE P CH + + C+ N W C + +DC +
Sbjct: 267 TGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCV-NGWTGESCSQNIDDCATAVCFH 325
Query: 928 NATCSARTCPPNQFSCASGRCIPISWT---CDLDDDC-GDRSDESASCAYPTCFPLTQFT 983
ATC R F CA P+ T C LDD C + E A C T
Sbjct: 326 GATCHDRVA---SFYCA----CPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICT 378
Query: 984 CNNGRCININWRCDND-NDCGDNSDEAGCSHSCSSTQ--FKCNSGRCIPEHWTCDGD-ND 1039
C G CD D ++C ++ C +TQ F C GR C+ D N+
Sbjct: 379 CPPG---FTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGP-RCETDVNE 434
Query: 1040 CGDYSDETHANCTNQATRPPGGC--HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSC 1097
C C NQAT C +F C +C+ G T D C
Sbjct: 435 C------LSGPCRNQAT-----CLDRIGQFTC----ICMA------GFTGTYCEVDIDEC 473
Query: 1098 EGVTHVCDPSVKFG-CKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNT 1156
+ P V G CKD S C C C+ S PC N
Sbjct: 474 QS-----SPCVNGGVCKDRVNGFS----C----TCPSGFSGSTCQLDVDECASTPCRNGA 520
Query: 1157 SVCLPPD------------KLCDGN-DDCGDGSDEGELCDQCSLNNGGCSHNCSVAPG 1201
PD LCD N DDC + C +G S +C+ APG
Sbjct: 521 KCVDQPDGYECRCAEGFEGTLCDRNVDDCSP-----DPCHHGRCVDGIASFSCACAPG 573
Score = 43.9 bits (102), Expect = 0.004
Identities = 106/492 (21%), Positives = 144/492 (29%), Gaps = 119/492 (24%)
Query: 3288 DVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCI 3347
D +PC +N G C + G C+C F C C ++ C
Sbjct: 852 DCDPNPC-LNGGSCQDGV-----GSFSCSCLPGF--------AGPRCARDVDECLSNPCG 897
Query: 3348 PFWWKCDTEDDCGDHSDE-----PPDCPEFKCRPGQFQCSTGICTNPAFICDGDND---- 3398
P C DH PP F C CS C N DG N
Sbjct: 898 P--------GTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCL 949
Query: 3399 CQDNSDEANCDIHVCLPSQFKCTNTNRCI---PGIFRCNGQDNCGDGEDERDCPEVTCAP 3455
C+ A+C C + C PG FRC C + C +
Sbjct: 950 CRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPG-FRCT----CLESFTGPQCQTLVDWC 1004
Query: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWK-- 3513
++ C RC+ C C P + C + C+++ I R +
Sbjct: 1005 SRQPCQNGGRCVQTGAYCL----C------PPGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054
Query: 3514 CDGEDDCGDGSDEPKEECDE-RT---CEPYQFRCKNNRC--------VPGRWQCD----Y 3557
C C D C E RT CE C C G + C+ Y
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Query: 3558 DND-CGDNSDEESCTPRPCSE--------------------------SEFSCANGRCIAG 3590
+ D C D+ DE C +PC +E C G +
Sbjct: 1115 NGDNCEDDVDE--CASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDS 1172
Query: 3591 RWKCDGDHDCAD--GSDEKDCTP-----RCDMDQFQCKSGHCIPLRWR-CDADAD----- 3637
+C + C D G C P RC+ D +C+SG C R C D
Sbjct: 1173 GPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRC 1232
Query: 3638 -CMDGSDEEACGTGVRTCPLDEFQCNNTLCKP-------LAWKCD-GEDDCGDNSDENPE 3688
C G C T + C Q + C+P L + C + G +
Sbjct: 1233 LCHAGFSGPRCQTVLSPCESQPCQ-HGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVAR 1291
Query: 3689 ECARFVCPPNRP 3700
C CP P
Sbjct: 1292 SCRELQCPVGVP 1303
Score = 42.4 bits (98), Expect = 0.011
Identities = 82/319 (25%), Positives = 108/319 (33%), Gaps = 59/319 (18%)
Query: 3305 CLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIP-------FWWKCDTED 3357
CL PGGG +C C F G +T +S C SQ +C P + C
Sbjct: 1222 CLQDPGGGFRCLCHAGF-SGPRCQTVLSPC-ESQPCQHGGQCRPSPGPGGGLTFTC---- 1275
Query: 3358 DCGDHSDEP---PDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCL 3414
H +P P C + QC G+ CQ C C
Sbjct: 1276 ----HCAQPFWGPRCERVARSCRELQCPVGV------------PCQQTPRGPRC---ACP 1316
Query: 3415 P--SQFKCTNTNRCIPGIFRCN-GQDNCGDGEDERDCPEVTCAPNQFQCSITKRCI-PRV 3470
P S C + PG + C G R P AP F+C+ + PR
Sbjct: 1317 PGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAP---LAP-FFRCACAQGWTGPR- 1371
Query: 3471 WVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEE 3530
C+ + S+EP C + C + C DG DC +P +
Sbjct: 1372 --CEAPAAAPEVSEEP-RCPRAACQAKRGDQRCDRECNSPGCGWDG-GDCSLSVGDPWRQ 1427
Query: 3531 CDERTCEPYQFRCKNN-RCVP--GRWQCDYDN-DCGDNSDEESCTPRPCSESEFSCANGR 3586
C+ C +R NN RC P C YDN DC E +C P A+GR
Sbjct: 1428 CEALQC----WRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGR 1483
Query: 3587 CIAGRWKCDGDHDCADGSD 3605
C G C+ + DG D
Sbjct: 1484 CDQG---CNTEECGWDGLD 1499
Score = 42.0 bits (97), Expect = 0.014
Identities = 45/170 (26%), Positives = 58/170 (34%), Gaps = 21/170 (12%)
Query: 104 EGPHCRELQGNCSRLGCQH--HCVPTLDG-PTCYCNSSFQLQADGKTCK-DFDECSVYGT 159
+G C EL C+ C+H C P C C +Q G C+ D DEC+
Sbjct: 765 QGRQC-ELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQ----GPRCQQDVDECAGPAP 819
Query: 160 CSQ--LCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA 217
C +CTN GSF C C GY SC D P L + Q+ + ++
Sbjct: 820 CGPHGICTNLAGSFSCTCHGGY----TGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSC 875
Query: 218 QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGF 267
P R + C HV C PG GF
Sbjct: 876 LPGFAGPRCARDVDECLSNPCGPGTCTDHV------ASFTCTCPPGYGGF 919
Score = 39.3 bits (90), Expect = 0.090
Identities = 37/149 (24%), Positives = 55/149 (36%), Gaps = 17/149 (11%)
Query: 34 CRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCN 93
CR+Q TC+ + G+ C + C + CQ + C+ +C N
Sbjct: 440 CRNQATCLDR----IGQFTCICMAGFTGTYC-EVDIDECQSSP--CVNGGVCKDR---VN 489
Query: 94 GVQDCMDGSDEGPHCRELQGNCSRLGCQH--HCVPTLDGPTCYCNSSFQLQADGKTC-KD 150
G G C+ C+ C++ CV DG C C F+ G C ++
Sbjct: 490 GFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE----GTLCDRN 545
Query: 151 FDECSVYGTCSQLCTNTDGSFICGCVEGY 179
D+CS C + SF C C GY
Sbjct: 546 VDDCSPDPCHHGRCVDGIASFSCACAPGY 574
Score = 38.1 bits (87), Expect = 0.20
Identities = 21/50 (42%), Positives = 24/50 (48%), Gaps = 6/50 (12%)
Query: 133 CYCNSSFQLQADGKTCKDFDECSVYGT-CSQL--CTNTDGSFICGCVEGY 179
C C F G +D DECS+ C L C NT GSF+C C GY
Sbjct: 377 CTCPPGF---TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
Score = 35.4 bits (80), Expect = 1.3
Identities = 46/176 (26%), Positives = 61/176 (34%), Gaps = 34/176 (19%)
Query: 26 TCSPKQ--FACRDQITCISKGWRCDGERDCPDGSDEAPEIC-PQSKAQRCQPNEHNCLGT 82
TC P F C + S C C DG + +C P CQ CL
Sbjct: 911 TCPPGYGGFHCEQDLPDCSPS-SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSR 969
Query: 83 ELCVPMSRLCNGVQD-----CMDGSDEGPHCRELQGNCSRLGCQH--HCVPTLDGPTCYC 135
C+ +C+ C++ S GP C+ L CSR CQ+ CV T G C C
Sbjct: 970 P-CLH-GGVCSAAHPGFRCTCLE-SFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLC 1024
Query: 136 NSSFQLQADGKTCKDFDECSVYGTCSQL-------------CTNTDGSFICGCVEG 178
+ G+ C D +Q+ C + D S C C EG
Sbjct: 1025 PPGW----SGRLC-DIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG 1075
Score = 33.5 bits (75), Expect = 5.0
Identities = 41/164 (25%), Positives = 58/164 (35%), Gaps = 24/164 (14%)
Query: 41 ISKGWRCDGERDCPDGSDEAPEICPQS-KAQRCQPNEHNCLGTELCVPMSRLC-----NG 94
+ G RC C D CP RC+ + + C +R C G
Sbjct: 1170 LDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGG 1229
Query: 95 VQDCMDGSDEGPHCRELQGNCSRLGCQH--HCVPTLDGP------TCYCNSSF---QLQA 143
+ GP C+ + C CQH C P+ GP TC+C F + +
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPS-PGPGGGLTFTCHCAQPFWGPRCER 1288
Query: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRS 187
++C++ +C V C Q T C C G L P RS
Sbjct: 1289 VARSCREL-QCPVGVPCQQ----TPRGPRCACPPG-LSGPSCRS 1326
Score = 33.1 bits (74), Expect = 6.5
Identities = 41/154 (26%), Positives = 59/154 (38%), Gaps = 23/154 (14%)
Query: 34 CRDQITCISK--GWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRL 91
CR TC++ +RC CP G +C ++ A C P+ C C L
Sbjct: 168 CRHGGTCLNTPGSFRCQ----CPAGY--TGPLC-ENPAVPCAPSP--CRNGGTCRQSGDL 218
Query: 92 CNGVQDCMDGSDEGPHCRELQGNCSRLGCQHH--CVPTLDGPTCYCNSSFQLQADGKTC- 148
C+ G EG +C +C C + CV ++ C C + G+ C
Sbjct: 219 TYDCA-CLPGF-EGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT----GQFCT 272
Query: 149 KDFDECSVYGTCSQ---LCTNTDGSFICGCVEGY 179
+D DEC + C NT G C CV G+
Sbjct: 273 EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGW 306
>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
Length = 4242
Score = 112 bits (279), Expect = 1e-23
Identities = 85/294 (28%), Positives = 107/294 (36%), Gaps = 65/294 (22%)
Query: 4151 CDRKKCEWLCLLSPSGPVC---TCPNG----KRLDNGTCVPVPSPTPPPDAPRPGTCNLQ 4203
C+ +C +C SG C +CP R ++G CV P T R C
Sbjct: 383 CEDGEC--ICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSR--ACPRD 438
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFT 4263
C G C C C Y+G+ C + C CR G C + C C G+T
Sbjct: 439 CRGRGRC-----ENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCESG-----RCMCWPGYT 488
Query: 4264 GPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAAD 4323
G C + C G C C +C C PGF G+ C R+C G C G C+ D
Sbjct: 489 GRDCGTRACPGDCRGRGRCV-----DGRCVCNPGFTGEDCGSRRCPGDCRGHGLCE---D 540
Query: 4324 GSRQCRCTAYFEGSRCEVNKC-------SRCLEGACVVN-----------------KQSG 4359
G C C A + G C C +CL+G CV Q G
Sbjct: 541 G--VCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHG 598
Query: 4360 ---DVTCNCTDGRVAPSC--LTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRC 4408
D C C +G V+ C TC +C G C C C P TGP C
Sbjct: 599 VCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEG-----RCLCDPGYTGPTC 647
Score = 97.8 bits (242), Expect = 2e-19
Identities = 75/267 (28%), Positives = 94/267 (35%), Gaps = 42/267 (15%)
Query: 4151 CDRKKCEWLCLLSPSGPVC-------TCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQ 4203
C R +C +C +GP C C R G CV + P + R +C
Sbjct: 197 CVRGRC--VCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQR--SCPRG 252
Query: 4204 CFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFT 4263
C G C +C C P YTGD C + C C G C C C G+T
Sbjct: 253 CSQRGRC-----EGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENG-----RCVCNPGYT 302
Query: 4264 GPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAAD 4323
G C + C C+ C +C C PG+ G+ C R C C G C D
Sbjct: 303 GEDCGVRSCPRGCSQRGRC-----KDGRCVCDPGYTGEDCGTRSCPWDCGEGGRC---VD 354
Query: 4324 GSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSC--LTCVGHC 4381
G +C C + G C C R G + D C C G C +C G C
Sbjct: 355 G--RCVCWPGYTGEDCSTRTCPRDCRG----RGRCEDGECICDTGYSGDDCGVRSCPGDC 408
Query: 4382 SNGGSCTMNSKMMPECQCPPHMTGPRC 4408
+ G C C C P TG C
Sbjct: 409 NQRGRCEDG-----RCVCWPGYTGTDC 430
Score = 87.4 bits (215), Expect = 3e-16
Identities = 150/579 (25%), Positives = 191/579 (32%), Gaps = 167/579 (28%)
Query: 2505 CRGGRIL------QDDLTCRAVNSSCRAQDEFECANGECI-NFSLTCD--GVPHCKDKSD 2555
C GGR + DD R+ C + C NG C+ N T + GV C
Sbjct: 259 CEGGRCVCDPGYTGDDCGMRSCPRGCSQRGR--CENGRCVCNPGYTGEDCGVRSC----- 311
Query: 2556 EKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGAD--------DCGDGSDEIP-------- 2599
P C+ R +C +GRCV + + G D DCG+G +
Sbjct: 312 --PRGCSQRG------RCKDGRCVCDPGY-TGEDCGTRSCPWDCGEGGRCVDGRCVCWPG 362
Query: 2600 -----CNKTACGV---GEFRCRDGTCIGNSSR-------------CNQFVDCEDASDEM- 2637
C+ C G RC DG CI ++ CNQ CED
Sbjct: 363 YTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCW 422
Query: 2638 -NCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGA---NDCGDYSDERDCPGVKR 2693
+ TDC S + C C VC+ DCG S DC G R
Sbjct: 423 PGYTGTDCGSR-------ACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGR 475
Query: 2694 PRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLC 2753
C SGRC M W DC C + C + RC+
Sbjct: 476 ---------CESGRC--MCWPGYTGRDCGTRACPGDCR-----GRGRCVDGRCVCNPGFT 519
Query: 2754 DGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCL 2813
+DCG + C G C G +C +CD D + S GC
Sbjct: 520 --GEDCG-----SRRCPG--------DCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCR 564
Query: 2814 YNSTCDDREFMCQN---------RQC---IPKHFVC-DHDRDCADGSDESPECEYPTCGP 2860
C D +C++ RQC +H VC D C +G S +C TC P
Sbjct: 565 GRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGY-VSEDCSIRTC-P 622
Query: 2861 SEF----RCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGR 2916
S RC GRCL D P C ++ C A + GR
Sbjct: 623 SNCHGRGRCEEGRCL----------------CDPGYTGPTCATR--MCPADCR---GRGR 661
Query: 2917 CVAEALLCN---GQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRL 2973
CV LC+ G +DCG C R+L Q C C GFR
Sbjct: 662 CVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQ----------CVCVEGFR- 710
Query: 2974 KDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYA 3012
G CA + C C R GS C+C +GYA
Sbjct: 711 ---GPDCA-IQTCPG--DCRGRGECHDGS--CVCKDGYA 741
Score = 81.3 bits (199), Expect = 2e-14
Identities = 119/449 (26%), Positives = 161/449 (35%), Gaps = 111/449 (24%)
Query: 3314 KCACPTNFYLGSDG--RTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPE 3371
+C C T Y G D R+C +C + C++ +C+ W T DCG + CP
Sbjct: 387 ECICDTG-YSGDDCGVRSCPGDCN-QRGRCEDGRCV--CWPGYTGTDCGSRA-----CPR 437
Query: 3372 FKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIF 3431
CR G+ +C G+C +C+ +D C + C P C RC G
Sbjct: 438 -DCR-GRGRCENGVC-----VCNAGYSGED------CGVRSC-PGD--CRGRGRCESG-- 479
Query: 3432 RCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ 3491
RC C G RDC C + C RC+ VC N G D C
Sbjct: 480 RCM----CWPGYTGRDCGTRACPGD---CRGRGRCVDGRCVC---NPGFTGED----CGS 525
Query: 3492 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNN-RCVP 3550
C D C+ G C CD + E+C R+C C+ +C+
Sbjct: 526 RRCPGD---CRGHGLCEDGVCVCD--------AGYSGEDCSTRSCPG---GCRGRGQCLD 571
Query: 3551 GRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCT 3610
GR C+ D G++ C P CS+ C +G CI W+ DC+ + +C
Sbjct: 572 GRCVCE-DGYSGEDCGVRQC-PNDCSQHGV-CQDGVCIC--WEGYVSEDCSIRTCPSNCH 626
Query: 3611 PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLD---EFQCNNTLCK 3667
R +C+ G C+ C G C T R CP D +C +C
Sbjct: 627 GRG-----RCEEGRCL-----------CDPGYTGPTCAT--RMCPADCRGRGRCVQGVC- 667
Query: 3668 PLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFR-------------------CKNDRV 3708
L G +DCG +E P C P R C D
Sbjct: 668 -LCHVGYGGEDCGQ--EEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPGD-- 722
Query: 3709 CLWIGRQCDGTDNCGDGTDEEDC--EPPT 3735
C G DG+ C DG EDC E PT
Sbjct: 723 CRGRGECHDGSCVCKDGYAGEDCGEEVPT 751
Score = 77.8 bits (190), Expect = 2e-13
Identities = 117/492 (23%), Positives = 167/492 (33%), Gaps = 128/492 (26%)
Query: 3479 CVDGSDE--PANCTQMTCGVDEFRCKDSGRCIPAR-------------W-----KCDGED 3518
C D +D P + G C D GRC+ R W C G
Sbjct: 167 CSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRG 226
Query: 3519 DCGDG-----SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPR 3573
C G + +C +R+C + + RC GR CD GD+ SC PR
Sbjct: 227 RCVQGVCVCRAGFSGPDCSQRSCP--RGCSQRGRCEGGRCVCD-PGYTGDDCGMRSC-PR 282
Query: 3574 PCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC----TPRCDMDQFQCKSGHCI--- 3626
CS+ C NGRC+ C G +DC PR + +CK G C+
Sbjct: 283 GCSQ-RGRCENGRCV-----------CNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDP 330
Query: 3627 ----------PLRWRCDADADCMDGS-------DEEACGTGVRTCPLDEFQCNNTLCKPL 3669
W C C+DG E C T RTCP D C+
Sbjct: 331 GYTGEDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCST--RTCPRD--------CRGR 380
Query: 3670 AWKCDGEDDCGDNSDENPEECARFVCPP--NRPFRCKNDRVCLWIG------------RQ 3715
DGE C ++ + ++C CP N+ RC++ R W G R
Sbjct: 381 GRCEDGECIC--DTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRD 438
Query: 3716 CDGTDNCGDGT-------DEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCG 3768
C G C +G EDC + C+ + C + RC+ DCG
Sbjct: 439 CRGRGRCENGVCVCNAGYSGEDCGVRSC-PGDCRGRGR--CESGRCMCWPGYTGR--DCG 493
Query: 3769 DGSDEEDCSIDPKLTS--CATNASICGDEARCVRTE---------KAAYCACRSGF---- 3813
+ DC + C N G++ R + C C +G+
Sbjct: 494 TRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGED 553
Query: 3814 ---HTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCAR--NFMKTHNTCKAEGSEYQ 3868
+ PG GC+ +CL G C +C + G C + N H C+
Sbjct: 554 CSTRSCPG--GCRGRGQCLD-GRC--VCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICW 608
Query: 3869 VLYIADDNEIRS 3880
Y+++D IR+
Sbjct: 609 EGYVSEDCSIRT 620
Score = 76.3 bits (186), Expect = 7e-13
Identities = 46/146 (31%), Positives = 53/146 (36%), Gaps = 25/146 (17%)
Query: 4199 TCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRC 4258
TC C G C + +C C P YTG C C CR G C C C
Sbjct: 620 TCPSNCHGRGRC-----EEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQG-----VCLC 669
Query: 4259 PTGFTGPKCTQQ-----VCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCE 4313
G+ G C Q+ C G C C QC C+ GF G C + C G C
Sbjct: 670 HVGYGGEDCGQEEPPASACPGGCGPRELCRAG-----QCVCVEGFRGPDCAIQTCPGDCR 724
Query: 4314 NFGTCQMAADGSRQCRCTAYFEGSRC 4339
G C DGS C C + G C
Sbjct: 725 GRGECH---DGS--CVCKDGYAGEDC 745
Score = 74.3 bits (181), Expect = 3e-12
Identities = 63/237 (26%), Positives = 81/237 (34%), Gaps = 42/237 (17%)
Query: 4151 CDRKKCEWLCLLSPSGPVCT---CPNGKR-----LDNGTCVPVPSPTPPPDAPRPGTCNL 4202
C+ C +C SG C+ CP G R LD G CV + R C
Sbjct: 538 CEDGVC--VCDAGYSGEDCSTRSCPGGCRGRGQCLD-GRCVCEDGYSGEDCGVRQ--CPN 592
Query: 4203 QCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGF 4262
C G C + C C Y + C + C +C G C C C G+
Sbjct: 593 DCSQHGVC-----QDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEG-----RCLCDPGY 642
Query: 4263 TGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQ-----CSGYCENFGT 4317
TGP C ++C C C Q C C G+ G+ C + C G C
Sbjct: 643 TGPTCATRMCPADCRGRGRCV-----QGVCLCHVGYGGEDCGQEEPPASACPGGCGPREL 697
Query: 4318 CQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSC 4374
C+ QC C F G C + C G C + D +C C DG C
Sbjct: 698 CRAG-----QCVCVEGFRGPDCAIQTC----PGDCRGRGECHDGSCVCKDGYAGEDC 745
Score = 73.6 bits (179), Expect = 4e-12
Identities = 110/439 (25%), Positives = 148/439 (33%), Gaps = 112/439 (25%)
Query: 861 CANSRC---IQERWKCDGDNDCLDNSDEAPALCHQHTCP---SDRFKCENNRCIPNRWLC 914
C+ C +R +C+G C+ + C +CP S R +CEN RC+ N
Sbjct: 244 CSQRSCPRGCSQRGRCEGGR-CVCDPGYTGDDCGMRSCPRGCSQRGRCENGRCVCNPGYT 302
Query: 915 DGDNDCGNSEDESNATCSARTCP---PNQFSCASGRCIPISWTCD---LDDDCGDRS--- 965
D C R+CP + C GRC+ CD +DCG RS
Sbjct: 303 GED-------------CGVRSCPRGCSQRGRCKDGRCV-----CDPGYTGEDCGTRSCPW 344
Query: 966 --DESASCAYPTCFPLTQFT---CN----------NGRCININWRCD---NDNDCGDNSD 1007
E C C +T C+ GRC + CD + +DCG S
Sbjct: 345 DCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSC 404
Query: 1008 EAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYS----DETHANCTNQATRPPGGCH 1063
C+ + +C GRC+ W DCG + C N G
Sbjct: 405 PGDCNQ-----RGRCEDGRCV--CWPGYTGTDCGSRACPRDCRGRGRCENGVCVCNAGYS 457
Query: 1064 TDEFQCR-LDGLCIPLRWRCD-GDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISK 1121
++ R G C R RC+ G C + C T C C+ RC+
Sbjct: 458 GEDCGVRSCPGDCRG-RGRCESGRCMCWPGYTGRDCG--TRACPGD----CRGRGRCV-- 508
Query: 1122 AWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDG---SDE 1178
DG C E+C S C P D C G+ C DG D
Sbjct: 509 ----DGRCVCNPGFTGEDCGSRRC---------------PGD--CRGHGLCEDGVCVCDA 547
Query: 1179 GELCDQCSLNN--GGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQK 1236
G + CS + GGC G C C G G D Q + C++H C
Sbjct: 548 GYSGEDCSTRSCPGGCRGRGQCLDGR---CVCEDGYS-GEDCGVRQCPNDCSQHGVCQDG 603
Query: 1237 CDQNKFSVKCSCYEGWVLE 1255
C C+EG+V E
Sbjct: 604 V--------CICWEGYVSE 614
Score = 70.5 bits (171), Expect = 4e-11
Identities = 49/169 (28%), Positives = 62/169 (36%), Gaps = 22/169 (13%)
Query: 4245 TCAASPS-GMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGN--QPQCRCLPGFLGD 4301
TC+ P G PTC PT P + +G C ++ +QG + +C C PG+ G
Sbjct: 155 TCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCN---DQGRCVRGRCVCFPGYTGP 211
Query: 4302 RCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDV 4361
C + C G C+ G C C C A F G C C R C +
Sbjct: 212 SCGWPSCPGDCQGRGRCVQGV-----CVCRAGFSGPDCSQRSCPR----GCSQRGRCEGG 262
Query: 4362 TCNCTDGRVAPSC--LTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRC 4408
C C G C +C CS G C C C P TG C
Sbjct: 263 RCVCDPGYTGDDCGMRSCPRGCSQRGRCENG-----RCVCNPGYTGEDC 306
Score = 43.9 bits (102), Expect = 0.004
Identities = 72/303 (23%), Positives = 98/303 (32%), Gaps = 63/303 (20%)
Query: 2757 DDCGD-GSDEAAHC------EGKTCGPSSF--SCPGTHVCVPERWLCDGDKDCADGADES 2807
DDC D G C G +CG S C G CV +C D + S
Sbjct: 189 DDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRS 248
Query: 2808 IAAGCLYNSTCDDREFMCQ---------NRQC---IPKHFVCDHDRDCADGSDESPECEY 2855
GC C+ +C R C + C++ R + +C
Sbjct: 249 CPRGCSQRGRCEGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGV 308
Query: 2856 PTC--GPSE-FRCANGRCL------------SSRQWECDGENDCHDQSDEAPKNPHCTSQ 2900
+C G S+ RC +GRC+ S W+C C D P T +
Sbjct: 309 RSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVD--GRCVCWPGYTGE 366
Query: 2901 EHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQ--DCED 2958
+ + GRC +C D G S D+ C + C C+Q CED
Sbjct: 367 DCSTRTCPRDCRGRGRCEDGECIC----DTGYSGDD--CGVRSC----PGDCNQRGRCED 416
Query: 2959 LKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDP 3018
+C C PG+ D G C RC N C+C GY+
Sbjct: 417 ----GRCVCWPGYTGTDCGSRA-----CPRDCRGRGRCENG----VCVCNAGYSGEDCGV 463
Query: 3019 HSC 3021
SC
Sbjct: 464 RSC 466
Score = 43.9 bits (102), Expect = 0.004
Identities = 69/266 (25%), Positives = 92/266 (34%), Gaps = 75/266 (28%)
Query: 807 CRVNNGGCSS-LCLATPG--SRQC---ACAED---QVLDADGVTCLANPSYVPPPQCQPG 857
CR G C S C+ PG R C AC D + DG C+ NP + G
Sbjct: 470 CR-GRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDG-RCVCNPGFT-------G 520
Query: 858 EFACANSRCIQERWKCDG-----DNDCLDNSDEAPALCHQHTCPSD---RFKCENNRCIP 909
E C + RC + C G D C+ ++ + C +CP R +C + RC+
Sbjct: 521 E-DCGSRRCPGD---CRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVC 576
Query: 910 NRWLCDGD-------NDCGNS-----------EDESNATCSARTCPPN---QFSCASGRC 948
D NDC E + CS RTCP N + C GRC
Sbjct: 577 EDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEGRC 636
Query: 949 IPISWTCDLDDDCGDRSDESASCAYPTCFP-LTQFTC-NNGRCININWRCD---NDNDCG 1003
+ CD PTC + C GRC+ C DCG
Sbjct: 637 L-----CD------------PGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCG 679
Query: 1004 DNSDEA-GCSHSCSSTQFKCNSGRCI 1028
A C C + C +G+C+
Sbjct: 680 QEEPPASACPGGCGPREL-CRAGQCV 704
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.458
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 209,243,504
Number of Sequences: 37866
Number of extensions: 11242290
Number of successful extensions: 52071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 348
Number of HSP's that attempted gapping in prelim test: 23547
Number of HSP's gapped (non-prelim): 11265
length of query: 4544
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4421
effective length of database: 13,590,000
effective search space: 60081390000
effective search space used: 60081390000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.