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Search of human proteins with 41281831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo
sapiens]
(920 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 1848 0.0
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 1795 0.0
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 461 e-129
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 294 3e-79
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 294 3e-79
gi|21614542 single-minded homolog 1 [Homo sapiens] 291 2e-78
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 240 5e-63
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 240 5e-63
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 223 6e-58
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 208 2e-53
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 208 2e-53
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 163 8e-40
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 129 1e-29
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 103 7e-22
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 100 8e-21
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 100 8e-21
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 100 8e-21
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 91 6e-18
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 88 3e-17
gi|4758010 clock [Homo sapiens] 84 8e-16
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 82 2e-15
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 79 2e-14
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 74 5e-13
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 70 9e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 67 6e-11
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 65 3e-10
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 65 3e-10
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 65 3e-10
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 62 3e-09
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 60 9e-09
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 1848 bits (4786), Expect = 0.0
Identities = 920/920 (100%), Positives = 920/920 (100%)
Query: 1 MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK
Sbjct: 1 MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
Query: 61 ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQ 120
ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQ
Sbjct: 61 ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQ 120
Query: 121 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 180
RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS
Sbjct: 121 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 180
Query: 181 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 240
VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL
Sbjct: 181 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 240
Query: 241 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 300
TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV
Sbjct: 241 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 300
Query: 301 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 360
VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE
Sbjct: 301 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 360
Query: 361 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 420
DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL
Sbjct: 361 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 420
Query: 421 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 480
SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS
Sbjct: 421 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 480
Query: 481 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 540
EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM
Sbjct: 481 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 540
Query: 541 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 600
QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS
Sbjct: 541 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 600
Query: 601 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 660
RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI
Sbjct: 601 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 660
Query: 661 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 720
SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA
Sbjct: 661 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 720
Query: 721 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 780
SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL
Sbjct: 721 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 780
Query: 781 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 840
QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF
Sbjct: 781 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 840
Query: 841 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 900
VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL
Sbjct: 841 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 900
Query: 901 PFPVYSNGIHAAQTLERKED 920
PFPVYSNGIHAAQTLERKED
Sbjct: 901 PFPVYSNGIHAAQTLERKED 920
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 1795 bits (4649), Expect = 0.0
Identities = 901/920 (97%), Positives = 901/920 (97%), Gaps = 19/920 (2%)
Query: 1 MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK
Sbjct: 1 MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
Query: 61 ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQ 120
ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKG AQ
Sbjct: 61 ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKG-------------------AQ 101
Query: 121 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 180
RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS
Sbjct: 102 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 161
Query: 181 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 240
VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL
Sbjct: 162 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 221
Query: 241 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 300
TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV
Sbjct: 222 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 281
Query: 301 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 360
VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE
Sbjct: 282 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 341
Query: 361 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 420
DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL
Sbjct: 342 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 401
Query: 421 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 480
SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS
Sbjct: 402 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 461
Query: 481 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 540
EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM
Sbjct: 462 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 521
Query: 541 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 600
QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS
Sbjct: 522 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 581
Query: 601 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 660
RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI
Sbjct: 582 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 641
Query: 661 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 720
SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA
Sbjct: 642 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 701
Query: 721 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 780
SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL
Sbjct: 702 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 761
Query: 781 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 840
QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF
Sbjct: 762 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 821
Query: 841 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 900
VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL
Sbjct: 822 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 881
Query: 901 PFPVYSNGIHAAQTLERKED 920
PFPVYSNGIHAAQTLERKED
Sbjct: 882 PFPVYSNGIHAAQTLERKED 901
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 461 bits (1186), Expect = e-129
Identities = 244/482 (50%), Positives = 319/482 (66%), Gaps = 56/482 (11%)
Query: 18 LQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFA 77
LQA RKEKSR+AARSRRGKEN EF+ELAKLLPLP AI+SQLDKASI+RL+++YL++R FA
Sbjct: 42 LQAQRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFA 101
Query: 78 NQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHL 137
G PPW LR GPP A RR P+AL EVFE HL
Sbjct: 102 ALGAPPWGLRAAGPPAGL-----------------------APGRRGPAALVSEVFEQHL 138
Query: 138 GSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 197
G HILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVE+TGSSVFDY+HPGDH E+ EQL
Sbjct: 139 GGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQL 198
Query: 198 GMKLP-PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
G++ P PG +SS+SSSS ++TPE +E++ + + ERSFF+RMKS
Sbjct: 199 GLRTPTPG----PPTPPSVSSSSSSSSSLADTPE-IEASLTKVPPSSLVQERSFFVRMKS 253
Query: 257 TLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRID 316
TLTKRG+H+K+SGYKVIH+TGRLR + +GLV + H LPP + E+ +
Sbjct: 254 TLTKRGLHVKASGYKVIHVTGRLR------------AHALGLVALGHTLPPAPLAELPLH 301
Query: 317 CHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKG 376
HM V R+++ L I+ CE+R+SD+MDL P ++VG+ CY F+H +D IR SH+DLL+KG
Sbjct: 302 GHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKG 361
Query: 377 QCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLP 436
Q +T YYRW+Q+ GG++W+QS AT+A + K+ E +++WV+++LS E TP+D QLP
Sbjct: 362 QVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLP 421
Query: 437 HL---------------PEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSE 481
PE +E + + +E+++ T G E + KG++ E
Sbjct: 422 ASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGDE 481
Query: 482 DP 483
DP
Sbjct: 482 DP 483
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 294 bits (752), Expect = 3e-79
Identities = 173/437 (39%), Positives = 242/437 (55%), Gaps = 73/437 (16%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
W G R P ++ LGSH+
Sbjct: 62 DAW---------------------------------GQPSRAGP----LDGVAKELGSHL 84
Query: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
LQ+LDGFVF + +GK +YISET S++LGLSQVELTG+S+++Y+HP DH EM L
Sbjct: 85 LQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQ 144
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
P LL + +ERSFF+RMK L KR
Sbjct: 145 PLHHHLLQE---------------------------------YEIERSFFLRMKCVLAKR 171
Query: 262 GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHM 319
+ SGYKVIH +G L++R + S QI+GLV V +LPP I E+++ +M
Sbjct: 172 NAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNM 231
Query: 320 FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV 379
F+ R ++DL +I+ ++R+++ P D++ K YH +H DV +R++H LL KGQ
Sbjct: 232 FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVT 291
Query: 380 TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP 439
TKYYR + K GG++W+QS AT+ N++++ I+ VNY+L+ EYK+ + + Q+
Sbjct: 292 TKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAK 351
Query: 440 EKTSESSETSDSESDSK 456
+ S + S S+ K
Sbjct: 352 SQDSWRTALSTSQETRK 368
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 294 bits (752), Expect = 3e-79
Identities = 173/437 (39%), Positives = 242/437 (55%), Gaps = 73/437 (16%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
W G R P ++ LGSH+
Sbjct: 62 DAW---------------------------------GQPSRAGP----LDGVAKELGSHL 84
Query: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
LQ+LDGFVF + +GK +YISET S++LGLSQVELTG+S+++Y+HP DH EM L
Sbjct: 85 LQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQ 144
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
P LL + +ERSFF+RMK L KR
Sbjct: 145 PLHHHLLQE---------------------------------YEIERSFFLRMKCVLAKR 171
Query: 262 GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHM 319
+ SGYKVIH +G L++R + S QI+GLV V +LPP I E+++ +M
Sbjct: 172 NAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNM 231
Query: 320 FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV 379
F+ R ++DL +I+ ++R+++ P D++ K YH +H DV +R++H LL KGQ
Sbjct: 232 FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVT 291
Query: 380 TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP 439
TKYYR + K GG++W+QS AT+ N++++ I+ VNY+L+ EYK+ + + Q+
Sbjct: 292 TKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAK 351
Query: 440 EKTSESSETSDSESDSK 456
+ S + S S+ K
Sbjct: 352 SQDSWRTALSTSQETRK 368
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 291 bits (744), Expect = 2e-78
Identities = 174/465 (37%), Positives = 251/465 (53%), Gaps = 80/465 (17%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
KEKS++AAR+RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
E G R SP ++ LGSH+L
Sbjct: 62 --------------------------------EAWGHSSRTSP----LDNVGRELGSHLL 85
Query: 143 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP 202
Q+LDGF+F + +GK +YISET S++LGLSQVELTG+S+++Y+HP DH EM L P
Sbjct: 86 QTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP 145
Query: 203 PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG 262
S + +ERSFF+RMK L KR
Sbjct: 146 ---------------------------------YHSHFVQEYEIERSFFLRMKCVLAKRN 172
Query: 263 VHIKSSGYKVIHITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMF 320
+ GYKVIH +G L++R Q +GLV V H+LPP + E+++ +MF
Sbjct: 173 AGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMF 232
Query: 321 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVT 380
+ R ++D+ +I+ ++R+++ P D++ K YH +H D +R +H LL KGQ T
Sbjct: 233 MFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTT 292
Query: 381 KYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPE 440
KYYR++ K+GG++W+QS ATI N++++ I+ VNY+L++ EYK + + Q+
Sbjct: 293 KYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI----- 347
Query: 441 KTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEP 485
S+ S T +T++ + +KS ++S++ P P
Sbjct: 348 ----SASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYP 388
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 240 bits (612), Expect = 5e-63
Identities = 153/449 (34%), Positives = 234/449 (52%), Gaps = 89/449 (19%)
Query: 22 RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
RKEKSRDAARSRR KE+ FYELA LPLP ++S LDKAS++RLTISYL++R + GD
Sbjct: 18 RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
L +E + +A +
Sbjct: 78 ----LDIE-----------------------------------------DDMKAQMNCFY 92
Query: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
L++LDGFV L +G +YIS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L +
Sbjct: 93 LKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR- 151
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
GL+ +G ++ +RSFF+RMK TLT R
Sbjct: 152 ---NGLVKKGKEQN------------------------------TQRSFFLRMKCTLTSR 178
Query: 262 G--VHIKSSGYKVIHITGRLRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRI 315
G ++IKS+ +KV+H TG + + + S+ G P LV++ +P P+ E+ +
Sbjct: 179 GRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPL 237
Query: 316 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 375
D F++R ++D+ YC+ RI++ M P +++G+ Y + HA D + + +H D+ K
Sbjct: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
Query: 376 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 435
GQ T YR + K GGY+W+++ AT+ N KN+ + I+ VNY++S D + Q
Sbjct: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
Query: 436 PHL--PEKTSESSETS-DSESDSKDTSGI 461
+ P ++S+ T ++ +S+DTS +
Sbjct: 358 ECVLKPVESSDMKMTQLFTKVESEDTSSL 386
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 240 bits (612), Expect = 5e-63
Identities = 153/449 (34%), Positives = 234/449 (52%), Gaps = 89/449 (19%)
Query: 22 RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
RKEKSRDAARSRR KE+ FYELA LPLP ++S LDKAS++RLTISYL++R + GD
Sbjct: 18 RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
L +E + +A +
Sbjct: 78 ----LDIE-----------------------------------------DDMKAQMNCFY 92
Query: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
L++LDGFV L +G +YIS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L +
Sbjct: 93 LKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR- 151
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
GL+ +G ++ +RSFF+RMK TLT R
Sbjct: 152 ---NGLVKKGKEQN------------------------------TQRSFFLRMKCTLTSR 178
Query: 262 G--VHIKSSGYKVIHITGRLRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRI 315
G ++IKS+ +KV+H TG + + + S+ G P LV++ +P P+ E+ +
Sbjct: 179 GRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPL 237
Query: 316 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 375
D F++R ++D+ YC+ RI++ M P +++G+ Y + HA D + + +H D+ K
Sbjct: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
Query: 376 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 435
GQ T YR + K GGY+W+++ AT+ N KN+ + I+ VNY++S D + Q
Sbjct: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
Query: 436 PHL--PEKTSESSETS-DSESDSKDTSGI 461
+ P ++S+ T ++ +S+DTS +
Sbjct: 358 ECVLKPVESSDMKMTQLFTKVESEDTSSL 386
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 223 bits (568), Expect = 6e-58
Identities = 138/439 (31%), Positives = 222/439 (50%), Gaps = 86/439 (19%)
Query: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
D ++ RKEKSRDAAR RR KE FYELA LPLP +++S LDKASI+RL IS+
Sbjct: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
Query: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAI 130
L+ S +C ++ A
Sbjct: 64 LRTHKLL---------------------------SSVC----------SENESEAEA--- 83
Query: 131 EVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDH 190
+ + + L++L+GF+ + Q+G +++SE +S ++GL+QVELTG S+FD+ HP DH
Sbjct: 84 ---DQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDH 140
Query: 191 VEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSF 250
E+ E L +K G G S+ D + ER F
Sbjct: 141 EEIRENLSLKNGSGFGKKSK--------------------------------DMSTERDF 168
Query: 251 FIRMKSTLTKRG--VHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQ----IMGLVVVAHA 304
F+RMK T+T RG V++KS+ +KV+H TG++++ + ++ + L+++
Sbjct: 169 FMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEP 228
Query: 305 LPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEG 364
+ P+ ++ +D F++R +MD+ YC++RI++ + P +++G+ Y F HA D E
Sbjct: 229 IQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSEN 288
Query: 365 IRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPE 424
+ SH +L KGQ V+ YR + K+GGY+W+++ T+ N +N + I+ VNY+LS E
Sbjct: 289 MTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIE 348
Query: 425 YKDTPMDIAQL-----PHL 438
D + Q PHL
Sbjct: 349 KNDVVFSMDQTESLFKPHL 367
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 208 bits (530), Expect = 2e-53
Identities = 140/451 (31%), Positives = 221/451 (49%), Gaps = 90/451 (19%)
Query: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 12 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 71
Query: 81 DPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSH 140
+ WN G P L +
Sbjct: 72 E--WNQVGAGGEP-------------------------------------------LDAC 86
Query: 141 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 87 YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--- 143
Query: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
+ Q+ + VE+ + ER F +RMKSTLT
Sbjct: 144 ---------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTS 172
Query: 261 RG--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEV 313
RG +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 173 RGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEP 232
Query: 314 RIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL 373
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL
Sbjct: 233 PLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLL 292
Query: 374 NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIA 433
+KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + +
Sbjct: 293 SKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLE 352
Query: 434 QLPHLP----EKTSESSETSDSESDSKDTSG 460
Q ++ + S + + + DS DT G
Sbjct: 353 QTEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 383
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 208 bits (530), Expect = 2e-53
Identities = 140/451 (31%), Positives = 221/451 (49%), Gaps = 90/451 (19%)
Query: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 14 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 73
Query: 81 DPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSH 140
+ WN G P L +
Sbjct: 74 E--WNQVGAGGEP-------------------------------------------LDAC 88
Query: 141 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 89 YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--- 145
Query: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
+ Q+ + VE+ + ER F +RMKSTLT
Sbjct: 146 ---------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTS 174
Query: 261 RG--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEV 313
RG +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 175 RGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEP 234
Query: 314 RIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL 373
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL
Sbjct: 235 PLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLL 294
Query: 374 NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIA 433
+KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + +
Sbjct: 295 SKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLE 354
Query: 434 QLPHLP----EKTSESSETSDSESDSKDTSG 460
Q ++ + S + + + DS DT G
Sbjct: 355 QTEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 385
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 163 bits (412), Expect = 8e-40
Identities = 100/330 (30%), Positives = 172/330 (52%), Gaps = 45/330 (13%)
Query: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 34 LKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---- 89
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
+ Q+ + VE+ + ER F +RMKSTLT R
Sbjct: 90 --------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSR 119
Query: 262 G--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVR 314
G +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 120 GRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPP 179
Query: 315 IDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLN 374
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL+
Sbjct: 180 LGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS 239
Query: 375 KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQ 434
KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + + Q
Sbjct: 240 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 299
Query: 435 LPHLP----EKTSESSETSDSESDSKDTSG 460
++ + S + + + DS DT G
Sbjct: 300 TEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 329
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 129 bits (324), Expect = 1e-29
Identities = 120/490 (24%), Positives = 203/490 (41%), Gaps = 77/490 (15%)
Query: 30 ARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRME 89
++ R + N E LA LLP P + ++LDK S++RL++SYL+ + F
Sbjct: 36 SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFF------------ 83
Query: 90 GPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 149
++ ++ +P E G Q +A E G +LQ+L+GFV
Sbjct: 84 ----------------DVALKSSPTERNGGQDN-CRAANFREGLNLQEGEFLLQALNGFV 126
Query: 150 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 209
+ + Y S T+ YLG Q ++ SV++ +H D E QL L P S
Sbjct: 127 LVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP-----S 181
Query: 210 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNT--LERSFFIRMKSTLTKRGVHIKS 267
Q T S + P+ V +P + +N+ +ER F R++ L S
Sbjct: 182 QCT----ESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLD------NS 231
Query: 268 SGYKVIHITGRLRL----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTR 323
SG+ ++ G+L+ + G +P Q + L +A L PP+I E+R +F T+
Sbjct: 232 SGFLAMNFQGKLKYLHGQKKKGKDGSILPPQ-LALFAIATPLQPPSILEIRTKNFIFRTK 290
Query: 324 VNMDLNIIYCENRISDYMDLTPVDIVGKRC-YHFIHAEDVEGIRHSHLDLLNKGQCVTKY 382
+D I C+ + + T ++ + Y FIHA D+ SH+ ++ G+
Sbjct: 291 HKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIV 350
Query: 383 YRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKT 442
+R + KN + W+QS+A + Y P+Y + + Q P E+
Sbjct: 351 FRLLTKNNRWTWVQSNARLL---------------YKNGRPDY----IIVTQRPLTDEEG 391
Query: 443 SESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCND 502
+E +++ T+G + E N DP P R K+G + + +
Sbjct: 392 TEHLRKRNTKLPFMFTTG------EAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTST 445
Query: 503 DGHSSSNPDS 512
S NP S
Sbjct: 446 LSKDSLNPSS 455
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 103 bits (257), Expect = 7e-22
Identities = 116/465 (24%), Positives = 197/465 (42%), Gaps = 88/465 (18%)
Query: 10 QDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
+D + +++A R+ S+ R RR K N EL+ ++P + +LDK +++R+ +
Sbjct: 97 EDGEHQVKMKAFREAHSQTEKR-RRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQ 155
Query: 70 YLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALA 129
+L+ S+KG+ +G+ R PS L
Sbjct: 156 HLR-----------------------SLKGLTN------------SYVGSNYR--PSFLQ 178
Query: 130 IEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPG 188
+ L IL++ +GF+F + E GK L++S++VS L Q LTG S+FD++HP
Sbjct: 179 ----DNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPK 234
Query: 189 DHVEMAEQL-GMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLE 247
D ++ EQL + P L+ A+ G S+ T V S S
Sbjct: 235 DVAKVKEQLSSFDISPREKLID---AKTGLQVHSNLHAGRT--RVYSGS----------R 279
Query: 248 RSFFIRMKSTL------------TKRGVHIKSSGYKVIHITGRLRL----RVSLSHGRTV 291
RSFF R+KS +K+ H K + IH TG LR V + R
Sbjct: 280 RSFFCRIKSCKISVKEEHGCLPNSKKKEHRK---FYTIHCTGYLRSWPPNIVGMEEERNS 336
Query: 292 P---SQIMGLVVVAHALP---PPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTP 345
S LV + P P E+ + F+TR ++ +Y + R + + P
Sbjct: 337 KKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
Query: 346 VDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQSSATIAIN 404
+++G CY + H +D + H +L +K + +T Y++ K+G ++ ++S N
Sbjct: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Query: 405 AKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETS 449
+ I+ VN L+ P + + LP + + ESS S
Sbjct: 457 PWTKELEYIVSVNTLVLG---HSEPGEASFLPCSSQSSEESSRQS 498
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 100 bits (248), Expect = 8e-21
Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 81/400 (20%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
+E + RR K N ELA L+P A++ +LDK +++R+ + ++K +R N
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 87
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
P + K + EL HL I
Sbjct: 88 ---------PYTEANYKPTFLSDDEL---------------------------KHL---I 108
Query: 142 LQSLDGFVFALN-QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
L++ DGF+F + GK L++SE+V L SQ +L G S+FDY+HP D ++ EQL
Sbjct: 109 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 168
Query: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
R L A + TP P S + RSFF RMK
Sbjct: 169 DTAPRERLID------AKTGLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPS 214
Query: 261 RGVHIKS-----------SGYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV- 301
V K + IH TG L+ ++ L ++ + LV +
Sbjct: 215 VKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIG 274
Query: 302 ---AHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIH 358
+H +P P E+R+ +V+R +D ++ + R + + P +++G CY + H
Sbjct: 275 RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFH 334
Query: 359 AEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQS 397
+D+ + H +L + + T Y++ K+G +I ++S
Sbjct: 335 QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRS 374
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 100 bits (248), Expect = 8e-21
Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 81/400 (20%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
+E + RR K N ELA L+P A++ +LDK +++R+ + ++K +R N
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
P + K + EL HL I
Sbjct: 131 ---------PYTEANYKPTFLSDDEL---------------------------KHL---I 151
Query: 142 LQSLDGFVFALN-QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
L++ DGF+F + GK L++SE+V L SQ +L G S+FDY+HP D ++ EQL
Sbjct: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
Query: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
R L A + TP P S + RSFF RMK
Sbjct: 212 DTAPRERLID------AKTGLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPS 257
Query: 261 RGVHIKS-----------SGYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV- 301
V K + IH TG L+ ++ L ++ + LV +
Sbjct: 258 VKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIG 317
Query: 302 ---AHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIH 358
+H +P P E+R+ +V+R +D ++ + R + + P +++G CY + H
Sbjct: 318 RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFH 377
Query: 359 AEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQS 397
+D+ + H +L + + T Y++ K+G +I ++S
Sbjct: 378 QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRS 417
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 100 bits (248), Expect = 8e-21
Identities = 98/400 (24%), Positives = 164/400 (41%), Gaps = 81/400 (20%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
+E + RR K N ELA L+P A++ +LDK +++R+ + ++K +R N
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130
Query: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
P + K + EL HL I
Sbjct: 131 ---------PYTEANYKPTFLSDDEL---------------------------KHL---I 151
Query: 142 LQSLDGFVFALN-QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
L++ DGF+F + GK L++SE+V L SQ +L G S+FDY+HP D ++ EQL
Sbjct: 152 LRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSS 211
Query: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
R L A + TP P S + RSFF RMK
Sbjct: 212 DTAPRERLID------AKTGLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPS 257
Query: 261 RGVHIKS-----------SGYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV- 301
V K + IH TG L+ ++ L ++ + LV +
Sbjct: 258 VKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIG 317
Query: 302 ---AHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIH 358
+H +P P E+R+ +V+R +D ++ + R + + P +++G CY + H
Sbjct: 318 RLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFH 377
Query: 359 AEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQS 397
+D+ + H +L + + T Y++ K+G +I ++S
Sbjct: 378 QDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRS 417
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 90.5 bits (223), Expect = 6e-18
Identities = 109/438 (24%), Positives = 185/438 (42%), Gaps = 61/438 (13%)
Query: 9 QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
+Q + +ERL +E + R RR K EL+ ++P +A+ + DK +I+R+ +
Sbjct: 80 EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
Query: 69 SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSAL 128
S++K +LR G NTS G PS L
Sbjct: 137 SHMK------------SLRGTG---NTSTDGSY----------------------KPSFL 159
Query: 129 AIEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187
+ + HL IL++ DGF+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP
Sbjct: 160 TDQELK-HL---ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHP 215
Query: 188 GDHVEMAEQLGM--KLPPGRGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTT 242
D ++ EQL GR L L GT E SS S S
Sbjct: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 275
Query: 243 DNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGL 298
++ R F+R + V + V+H TG ++ VSL Q
Sbjct: 276 PVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKF 335
Query: 299 VVVA----HALPPPTINEVRIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKR 352
+VA P ++ C F++R N++ + ++R + P +++GK
Sbjct: 336 CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKN 395
Query: 353 CYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEK 411
F H ED + +R S ++ KGQ ++ +R+ KN ++W+++S+ N + +
Sbjct: 396 IVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIE 455
Query: 412 NIIWVNYLLSNPEYKDTP 429
II N + N + P
Sbjct: 456 YIICTNTNVKNSSQEPRP 473
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 88.2 bits (217), Expect = 3e-17
Identities = 105/424 (24%), Positives = 178/424 (41%), Gaps = 58/424 (13%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125
Query: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
+LR G NTS G PS L + + HL IL
Sbjct: 126 --SLRGTG---NTSTDGSY----------------------KPSFLTDQELK-HL---IL 154
Query: 143 QSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM-- 199
++ DGF+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP D ++ EQL
Sbjct: 155 EAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSE 214
Query: 200 KLPPGRGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
GR L L GT E SS S S ++ R F+R +
Sbjct: 215 NALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRC 274
Query: 257 TLTKRGVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPP 308
V + V+H TG ++ VSL Q +VA P
Sbjct: 275 RNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSP 334
Query: 309 TINEVRIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIR 366
++ C F++R N++ + ++R + P +++GK F H ED + +R
Sbjct: 335 NCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLR 394
Query: 367 HSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEY 425
S ++ KGQ ++ +R+ KN ++W+++S+ N + + II N + N
Sbjct: 395 DSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQ 454
Query: 426 KDTP 429
+ P
Sbjct: 455 EPRP 458
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 83.6 bits (205), Expect = 8e-16
Identities = 94/452 (20%), Positives = 187/452 (41%), Gaps = 76/452 (16%)
Query: 9 QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
+ D + +R+ + EK R R + N EL +LP A ++DK+++++ +I
Sbjct: 28 EDDKDKAKRVSRNKSEKKR------RDQFNVLIKELGSMLPGNAR---KMDKSTVLQKSI 78
Query: 69 SYL-KMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSA 127
+L K ++ Q D +R + WK P+
Sbjct: 79 DFLRKHKEITAQSDAS-EIRQD-------------WK--------------------PTF 104
Query: 128 LAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187
L+ E F + L++LDGF A+ +G +Y+SE+V+ L +L S+F+++
Sbjct: 105 LSNEEFTQLM----LEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPE 160
Query: 188 GDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLE 247
G+H E+ + L L L + T +P E + T E
Sbjct: 161 GEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPS---------TYE 211
Query: 248 RSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPP 307
FI +L + SS + T + +H + ++ + V A P
Sbjct: 212 YVKFIGNFKSLNS----VSSSAHNGFEGT------IQRTHRPSYEDRVCFVATVRLATPQ 261
Query: 308 -----PTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDV 362
T+ E + F +R +++ ++ ++R + P +++G Y + H +D+
Sbjct: 262 FIKEMCTVEEPNEE---FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDL 318
Query: 363 EGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSN 422
E + H L+ G+ + YYR++ K +IW+Q+ I + N+ + I+ + ++S
Sbjct: 319 ENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSY 378
Query: 423 PEYK-DTPMDIAQLPHLPEKTSESSETSDSES 453
E + + ++ LPE ++ S+ S S++
Sbjct: 379 AEVRAERRRELGIEESLPETAADKSQDSGSDN 410
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 82.4 bits (202), Expect = 2e-15
Identities = 104/446 (23%), Positives = 184/446 (41%), Gaps = 92/446 (20%)
Query: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
+E + R RR K EL+ ++P +A+ + DK +I+R+ +S++K
Sbjct: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114
Query: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
++R G N S G PS L E L IL
Sbjct: 115 --SMRGTG---NKSTDGAY----------------------KPSFLT----EQELKHLIL 143
Query: 143 QSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
++ DGF+F + E G+ +Y+S++V+ L Q E GS++++ VHP D ++ EQL
Sbjct: 144 EAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLC--- 200
Query: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMK------ 255
T+E+ + ++ T + S + + RSF RM+
Sbjct: 201 ----------TSENSMTGRILDLKTGTVKKEGQQSSMRMCMGS--RRSFICRMRCGNAPL 248
Query: 256 --------STLTKR------GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGL--- 298
+T+ KR V + Y V+H TG ++ G T+P + +
Sbjct: 249 DHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPA--GMTIPEEDADVGQG 306
Query: 299 ---VVVAHALPPPTINEVRIDCH------MFVTRVNMDLNIIYCENRISDYMDLTPVDIV 349
+VA T + V +D + F++R N D I + + R + P D++
Sbjct: 307 SKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLL 366
Query: 350 GKRCYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNA 408
GK F H ED +R S ++ KGQ ++ YR+ KN ++ I++S+ N +
Sbjct: 367 GKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSD 426
Query: 409 NEKNIIWVNYLLSNPEYKDTPMDIAQ 434
+ II N + + + +++ Q
Sbjct: 427 EIEYIICTNTNVKQLQQQQAELEVHQ 452
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 79.0 bits (193), Expect = 2e-14
Identities = 61/203 (30%), Positives = 90/203 (44%), Gaps = 38/203 (18%)
Query: 14 RRERLQ----ALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
RR LQ A+ EKS + R R + N E LA LLP P I S+LDK S++RL++S
Sbjct: 18 RRRPLQKQRPAVGAEKSNPSKR-HRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVS 76
Query: 70 YLKMRDFAN--QGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSA 127
YL+++ F Q P P S C + G+
Sbjct: 77 YLRVKSFFQVVQEQSSRQPAAGAPSPGDS-----------------CPLAGSA------- 112
Query: 128 LAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187
V E L +L+SL+GF ++ EG Y S T+ YLG Q ++ +++DY+H
Sbjct: 113 ----VLEGRL---LLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHV 165
Query: 188 GDHVEMAEQLGMKLPPGRGLLSQ 210
D + QL + P + + Q
Sbjct: 166 DDRQDFCRQLHWAMDPPQVVFGQ 188
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 74.3 bits (181), Expect = 5e-13
Identities = 95/502 (18%), Positives = 196/502 (39%), Gaps = 104/502 (20%)
Query: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
D ++R + + KS + RR + N EL+ +LP T ++DK +++ I +
Sbjct: 2 DEDEKDRAKRASRNKSE---KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55
Query: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAI 130
L+ + E+ + C++ Q+ PS L+
Sbjct: 56 LQKHN------------------------------EVSAQTEICDI---QQDWKPSFLSN 82
Query: 131 EVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDH 190
E F + L++LDGF+ A+ +G +Y+S++++ LG ++ ++ +++ +H
Sbjct: 83 EEFTQLM----LEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEH 138
Query: 191 VEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSF 250
E+ + L SS T P SP L +D+ LE F
Sbjct: 139 SEVYKIL------------------------SSHMLVTDSP----SPEYLKSDSDLE--F 168
Query: 251 FIRM-KSTLTKRGVHIKSSGYKVIHITGRLR------------LRVSLSHGRTVP-SQIM 296
+ + + +L + + Y+ I G R +LS VP + +
Sbjct: 169 YCHLLRGSLNPK----EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEV 224
Query: 297 GLVVVAHALPPPTINEVRI---DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRC 353
+ P + E+ I F +R +++ ++ ++R + P +++G
Sbjct: 225 CFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSG 284
Query: 354 YHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNI 413
Y + H +D+E + H L+ G+ + YR++ K +IW+Q+ I + N+ + I
Sbjct: 285 YDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFI 344
Query: 414 IWVNYLLSNPEYK----------DTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITE 463
+ + ++S + + D P + L +K S + SG+
Sbjct: 345 VCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNT 404
Query: 464 DNENSKSDEKGNQSENSEDPEP 485
+ S S ++S ++ EP
Sbjct: 405 SHSPSASSRSSHKSSHTAMSEP 426
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 70.1 bits (170), Expect = 9e-12
Identities = 105/484 (21%), Positives = 164/484 (33%), Gaps = 113/484 (23%)
Query: 26 SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85
++ A+++RR + N E L +LLPL A +L I+ L Y + F G P
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61
Query: 86 LRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSL 145
+ GP S + ++ I+ +L
Sbjct: 62 --LAGPTGLLSAQELE--------------------------------------DIVAAL 81
Query: 146 DGFVFALNQEGKFLYISETVSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPP 203
GF+ EGK LY+SE+VS +LG S V+L G S++D + P DH+ + +QL
Sbjct: 82 PGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------ 135
Query: 204 GRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGV 263
T PS L TD R F R T + +
Sbjct: 136 -------------------------------TLPSALDTD----RLFRCRFN---TSKSL 157
Query: 264 HIKSSGYKVIHITGRLRLRVSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMF 320
+S+G K++ I GR ++ P + L P P + MF
Sbjct: 158 RRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMF 217
Query: 321 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV- 379
+R DL ++ + Y+ +++ K Y +H ED+ H LL + +
Sbjct: 218 QSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQ 277
Query: 380 -TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI------ 432
R K GG+ WI + E I NY +S+ E +
Sbjct: 278 AEMVVRLQAKTGGWAWI-----YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQ 332
Query: 433 --------AQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPE 484
LP PE E S + G + E S + E P
Sbjct: 333 AAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPR 392
Query: 485 PDRK 488
P ++
Sbjct: 393 PSKE 396
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 67.4 bits (163), Expect = 6e-11
Identities = 75/337 (22%), Positives = 129/337 (38%), Gaps = 11/337 (3%)
Query: 442 TSESSETSDS-ESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 500
+SESS++SDS +SDS D+S N NS + N S++S+ + N +
Sbjct: 698 SSESSDSSDSSDSDSSDSSD--SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755
Query: 501 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
+D SS++ DS DS DS + SD N D + + + SD + +
Sbjct: 756 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD-SSDSSD 814
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGG-SASRRRLSSASSPGGLDAGLVE 619
S SDS+ SDS+ + + SS G S S R S++S D+
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 620 PPRLLSSPNSASVLKIKTEISEPIN-FDNDSSIWNYPPNREISRN-----ESPYSMTKPP 673
S + ++ ++ S+ N D+DSS + + S N ES S
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 674 SSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDP 733
SS+ S DS + +D ++ + S+ ++ + +SD
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Query: 734 LSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNS 770
S++ D + + S+++S
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031
Score = 67.4 bits (163), Expect = 6e-11
Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 6/250 (2%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS++SDS SDS D+S ++ +++S S + + S++S+ + + N + +
Sbjct: 1039 SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS + DS DS DS + SD N D + + SD + S
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS---SDSSDSSESSDSS 1154
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPP 621
+SDS+ SDS+ + + SS +S SS SS + +
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214
Query: 622 RLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSP 681
SS +S S + S + +DSS + N S + S S + S++ S
Sbjct: 1215 D--SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272
Query: 682 QGGGGGGGGG 691
G G G
Sbjct: 1273 SKSGNGNNNG 1282
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 11/169 (6%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPE-PDRKKSGNACDNDMNC 500
+S+SS++SDS+SDS + + D+++ N S++S++ + D S N+ D+ +
Sbjct: 613 SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS-DS 671
Query: 501 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
+D SSS+ DS +S DS + SD N D + + +S N
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS---------DSSDSSDSSNSN 722
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S SDS+ SDS+ + + SS +S SS SS
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Score = 63.5 bits (153), Expect = 8e-10
Identities = 55/221 (24%), Positives = 96/221 (43%), Gaps = 19/221 (8%)
Query: 444 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDD 503
+S TSD+ + + +G +++N KSD +S++S+ D S ++ D+ + + D
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573
Query: 504 GHSSSNPDSRDSD----------DSFEHSDFENPKAGEDGFGALGAMQIKVE----RYVE 549
+SSS+ DS DSD DS SD + D + + K +
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDS 633
Query: 550 SESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S+SD + + +S +SDS+ +SDS+ + + SS +S SS SS
Sbjct: 634 SDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSS 693
Query: 610 PGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSS 650
+ + SS +S S ++ S + D+DSS
Sbjct: 694 DSSNSSESSD-----SSDSSDSDSSDSSDSSNSNSSDSDSS 729
Score = 63.2 bits (152), Expect = 1e-09
Identities = 70/336 (20%), Positives = 132/336 (39%), Gaps = 18/336 (5%)
Query: 443 SESSETSDSES-------DSKDTSGITEDNENS-KSDEKGNQSENSEDPEPDRKKSGNAC 494
S+SS++SDS+S DS D+S ++ +++S SD K + S++ D KS ++
Sbjct: 585 SDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644
Query: 495 DNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDL 554
N + +D+ SS + +S +S DS + SD + + D + + SD
Sbjct: 645 SNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSD- 703
Query: 555 RLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLD 614
+ +S SDS+ SDS+ + + S + S S +S+ S D
Sbjct: 704 ---SSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 760
Query: 615 AGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPS 674
+ SS +S S + S N ++SS + N S N S S + S
Sbjct: 761 SSNSSD----SSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816
Query: 675 SEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPL 734
+ + + DS + +DG+ + + S+ ++ + +SD
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSS--DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 735 SPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNS 770
+ S+ D + + + S S++
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910
Score = 63.2 bits (152), Expect = 1e-09
Identities = 68/326 (20%), Positives = 117/326 (35%), Gaps = 4/326 (1%)
Query: 443 SESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 500
S SS++SDS SDS D+S ++ +++S S + S++S+ + + + N
Sbjct: 971 SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030
Query: 501 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
+D SS + DS DS DS + SD N D + + S+ +
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEP 620
S +SDS+ SDS+ + + SS +S SS SS + E
Sbjct: 1091 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES 1150
Query: 621 PRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPS 680
S +S+ + D+ +S + + ++S S SS+ S
Sbjct: 1151 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1210
Query: 681 PQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSA 740
DS + +D ++ + S+ ++ + +SD S
Sbjct: 1211 SDSSDSSDSSDSSDSSDSSDSNESSDSSD--SSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268
Query: 741 SPRDKHPGNGGGGGGGGGGAGGGGPS 766
S GNG G G S
Sbjct: 1269 SDSQSKSGNGNNNGSDSDSDSEGSDS 1294
Score = 62.4 bits (150), Expect = 2e-09
Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 3/171 (1%)
Query: 442 TSESSETSDSES-DSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 500
+S+SS +SDS+S DS ++S ++ + +S S E N S+NS + + + N
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 501 NDDGHSSSNPDSRDSDD--SFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQN 558
+D +SS + +S DS D S + SD N D + + SD +
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 559 CESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S +SDS+ SDS+ + + SS +S SS SS
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1064
Score = 62.4 bits (150), Expect = 2e-09
Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 3/170 (1%)
Query: 442 TSESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 499
+SESS +SD+ SDS ++S ++ +++S S + N S++S + S ++ D+ N
Sbjct: 923 SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSS-N 981
Query: 500 CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 559
+D SS + DS DS DS SD + D + + SD +
Sbjct: 982 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041
Query: 560 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S +SDS+ SDS+ + + SS +S SS SS
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS 1091
Score = 62.4 bits (150), Expect = 2e-09
Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 1/168 (0%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS++SDS SDS D+S ++ +++S S + N S++S + + + + +
Sbjct: 985 SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS + DS +S DS + SD + D + + + + SD + S
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
+SDS+ SDS+ + + SS ++S SS SS
Sbjct: 1104 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Score = 61.6 bits (148), Expect = 3e-09
Identities = 46/175 (26%), Positives = 79/175 (45%), Gaps = 7/175 (4%)
Query: 442 TSESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDND-- 497
+S++S +SDS SDS D+S + +++S S + N S++S+ D S N+ D+
Sbjct: 929 SSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988
Query: 498 ---MNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDL 554
+ +D SS++ DS DS DS + S+ + D + + SD
Sbjct: 989 SDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS 1048
Query: 555 RLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
+ S +SDS+ SDS+ + + SS + ++S SS SS
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Score = 61.2 bits (147), Expect = 4e-09
Identities = 45/170 (26%), Positives = 76/170 (44%), Gaps = 3/170 (1%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S SS++SDS S+S D+S + ++NS S + N S++S+ + + + N +
Sbjct: 908 SSNSSDSSDS-SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966
Query: 502 D--DGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 559
D D +SS + DS +S DS + SD + D + + + SD +
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026
Query: 560 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S +SDS+ SDS+ + + SS +S SS SS
Sbjct: 1027 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076
Score = 61.2 bits (147), Expect = 4e-09
Identities = 43/168 (25%), Positives = 74/168 (44%), Gaps = 1/168 (0%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS +SDS SDS D+S + +++S S + N S++S+ + + + + +
Sbjct: 997 SSDSSNSSDS-SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1055
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
+ SS + DS DS DS + SD + D + + SD + S
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
+SDS+ SDS+ + + SS + +S SS SS
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163
Score = 60.8 bits (146), Expect = 5e-09
Identities = 40/168 (23%), Positives = 73/168 (43%), Gaps = 2/168 (1%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+S + S+SDS D+S ++ +++S S + + S++S+ K ++ D+D
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK-- 639
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D S++ DS D+ DS + S+ N D + + SD + S
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
+SDS+ SDS + +S+ + +S SS SS
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Score = 60.8 bits (146), Expect = 5e-09
Identities = 43/170 (25%), Positives = 73/170 (42%), Gaps = 5/170 (2%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS++SDS S+S ++S ++ +++ SD + + NS D + + N + +
Sbjct: 686 SSDSSDSSDS-SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS++ DS DS DS SD + D + + SD + S
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPG 611
+SDS+ SDS+ + +S S+ SS SS G
Sbjct: 805 NSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD----SSDSSDG 850
Score = 60.1 bits (144), Expect = 9e-09
Identities = 44/160 (27%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEP-DRKKSGNACDNDMNC 500
+S+SS++SDS S+S D+S +E +++S S + + S++S+ + D S N+ D+ +
Sbjct: 1129 SSDSSDSSDS-SNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS-DS 1186
Query: 501 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
+D SS + DS DS DS + SD + D + + SD +
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 600
S +SDS+ SDS+ ++ + ++ + + K GS S
Sbjct: 1247 SNSSDSSDSSDSS-DSTSDSNDESDSQSKSGNGNNNGSDS 1285
Score = 60.1 bits (144), Expect = 9e-09
Identities = 39/141 (27%), Positives = 71/141 (50%), Gaps = 3/141 (2%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS++SDS SDS D+S ++ +++S S + + S++S+ + + + + +
Sbjct: 1162 SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1220
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS + DS +S DS + SD + D + + + ES+S + N +
Sbjct: 1221 DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN 1280
Query: 562 LTSDSAKDSDSAGEAGAQASS 582
SDS DSDS G ++S
Sbjct: 1281 NGSDS--DSDSEGSDSNHSTS 1299
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/168 (25%), Positives = 72/168 (42%), Gaps = 1/168 (0%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S SS++SDS SDS D+S ++ + +S S + S++S+ + + + N +
Sbjct: 1000 SSNSSDSSDS-SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1058
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS + DS DS DS + SD D + + SD + S
Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1118
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
+S+S+ SDS+ + + SS + +S SS SS
Sbjct: 1119 DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSS 1166
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/169 (24%), Positives = 74/169 (43%), Gaps = 1/169 (0%)
Query: 442 TSESSETSDSES-DSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 500
+S SS++SDS S DS D+S ++ +++S S + + S++S + + N +
Sbjct: 962 SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021
Query: 501 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
++ SS++ DS DS DS + SD + D + + SD +
Sbjct: 1022 SNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1081
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S +SDS+ S+S+ + + SS +S SS SS
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1130
Score = 58.5 bits (140), Expect = 3e-08
Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 23/234 (9%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+SS++SDS SDS +S + +++S S + N SE+S+ + S ++ D+ + +
Sbjct: 665 SSDSSDSSDS-SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 502 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 561
D SS++ DS DS +S + SD + D SD + S
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS------------------SDSSDSSNSS 765
Query: 562 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPP 621
+SDS+ SDS+ + + S+ +S SS SS D+ +
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS----DSSDSDSS 821
Query: 622 RLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSS 675
S NS+ + D+ + NR S N S S + S+
Sbjct: 822 NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875
Score = 57.4 bits (137), Expect = 6e-08
Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 2/171 (1%)
Query: 441 KTSESSETSDSESDSKD--TSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDM 498
K+ S SDS+SDS D +S ++++++S S N S++S+ + S + N
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687
Query: 499 NCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQN 558
+ +D SS++ +S DS DS + ++ + + + SD +
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 559 CESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 609
S +SDS+ SDS+ + + SS +S SS SS
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS 798
Score = 54.7 bits (130), Expect = 4e-07
Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 18/175 (10%)
Query: 440 EKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 499
+++ ++ SDS+ D S T D NS S+ GN + D K ++ D+D +
Sbjct: 496 DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSS 555
Query: 500 CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 559
+ + SS+ DS DS SD ++ + S+SD +
Sbjct: 556 DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD---------------SSDSD---SSD 597
Query: 560 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLD 614
S +SDS+ SDS+ + + SS + + + S S+ S ++S D
Sbjct: 598 SSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Score = 53.9 bits (128), Expect = 7e-07
Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 397 SSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSK 456
S ++ + N+ ++N+ + + SN D + + S +S S + SDS
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833
Query: 457 DTSGITEDNENSKS-----DEKGNQSENSEDPE-PDRKKSGNACD--NDMNCNDDGHSSS 508
D+S ++ +++S S + N+S++S + D S N+ D + + N+ +SS
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 509 NPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAK 568
+ DS +S DS + SD N D + + + + SD + S +SDS+
Sbjct: 894 SSDSSNSSDS-DSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952
Query: 569 DSDSAGEAGAQASS 582
SDS+ + + SS
Sbjct: 953 SSDSSNSSDSSNSS 966
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/233 (24%), Positives = 93/233 (39%), Gaps = 15/233 (6%)
Query: 441 KTSESSETSDSESDSKDTSGITE-----DNENSKSDEKGNQSENSEDPEPDRKKSGNACD 495
K S+ SDS SD D+ + D+ NS + GN NSE + + G+A
Sbjct: 435 KVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSES-DNNSSSRGDASY 493
Query: 496 NDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLR 555
N D+G+ S + + D DDS SD N + +G G G + +SD
Sbjct: 494 NSDESKDNGNGSDSKGAED-DDSDSTSDTNN--SDSNGNGNNGNDDNDKSDSGKGKSD-- 548
Query: 556 LQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDA 615
+ +S +SDS+ SDS+ + + +S + +S S+ S D+
Sbjct: 549 --SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS--DSSDSSNSSDS 604
Query: 616 GLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYS 668
S + +S K + SE + D+DS + N S + S S
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS 657
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 442 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 501
+S+S+E+SDS SDS D+S + +++S S + + + +S D + KSGN +N + +
Sbjct: 1228 SSDSNESSDS-SDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSD 1286
Query: 502 DDGHSSSNPDSRDSD 516
D S + S D
Sbjct: 1287 SDSEGSDSNHSTSDD 1301
Score = 43.1 bits (100), Expect = 0.001
Identities = 40/209 (19%), Positives = 82/209 (39%), Gaps = 8/209 (3%)
Query: 444 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDD 503
+ +SD + + D + +++N +S+ D N E+ ++ K D+D + +D
Sbjct: 463 DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSD-STSDT 521
Query: 504 GHSSSNPDSRDSDDSFEHSDF---ENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 560
+S SN + + +D + SD ++ + D + + +S + +
Sbjct: 522 NNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSD 581
Query: 561 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEP 620
S SDS+ SDS + +S S+ + SS S D+
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS----D 637
Query: 621 PRLLSSPNSASVLKIKTEISEPINFDNDS 649
+ SS +++S ++ S+ N N S
Sbjct: 638 SKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666
Score = 33.5 bits (75), Expect = 0.93
Identities = 26/108 (24%), Positives = 47/108 (43%), Gaps = 14/108 (12%)
Query: 440 EKTSESSETSDSESDSKDTSGITEDN--ENSKSDEKGNQSENSEDP---EPDRKKSGNAC 494
E T + + + +++ T G ED +NS GN ++ ED + + +++GN
Sbjct: 212 EITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGK 271
Query: 495 DNDMNCN---------DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDG 533
D+ N +D H SS + DS + ++ E+P DG
Sbjct: 272 DSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDG 319
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 27/167 (16%)
Query: 31 RSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEG 90
+ RR +EN ELA+LL +A S +D S+ LK
Sbjct: 33 KRRREQENKYLEELAELL---SANISDIDSLSVKPDKCKILKK----------------- 72
Query: 91 PPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVF 150
+V IQ+ K + T + + S S IE + LG +L++LDGF F
Sbjct: 73 -----TVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIE--KESLGPLLLEALDGFFF 125
Query: 151 ALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 197
+N EG+ +++SE V+ YLG +Q EL +SV+ +H GDH E + L
Sbjct: 126 VVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 27/167 (16%)
Query: 31 RSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEG 90
+ RR +EN ELA+LL +A S +D S+ LK
Sbjct: 33 KRRREQENKYLEELAELL---SANISDIDSLSVKPDKCKILKK----------------- 72
Query: 91 PPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVF 150
+V IQ+ K + T + + S S IE + LG +L++LDGF F
Sbjct: 73 -----TVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIE--KESLGPLLLEALDGFFF 125
Query: 151 ALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 197
+N EG+ +++SE V+ YLG +Q EL +SV+ +H GDH E + L
Sbjct: 126 VVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 27/167 (16%)
Query: 31 RSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEG 90
+ RR +EN ELA+LL +A S +D S+ LK
Sbjct: 33 KRRREQENKYLEELAELL---SANISDIDSLSVKPDKCKILKK----------------- 72
Query: 91 PPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVF 150
+V IQ+ K + T + + S S IE + LG +L++LDGF F
Sbjct: 73 -----TVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIE--KESLGPLLLEALDGFFF 125
Query: 151 ALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 197
+N EG+ +++SE V+ YLG +Q EL +SV+ +H GDH E + L
Sbjct: 126 VVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/190 (28%), Positives = 91/190 (47%), Gaps = 45/190 (23%)
Query: 9 QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
+Q + +ERL +E + R RR K EL+ ++P +A+ + DK +I+R+ +
Sbjct: 80 EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
Query: 69 SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSAL 128
S++K +LR G NTS G PS L
Sbjct: 137 SHMK------------SLRGTG---NTSTDGSY----------------------KPSFL 159
Query: 129 AIEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187
+ + HL IL++ DGF+F ++ E G+ +Y+S++V+ L Q E GS+++D VHP
Sbjct: 160 TDQELK-HL---ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHP 215
Query: 188 GDHVEMAEQL 197
D ++ EQL
Sbjct: 216 DDVDKLREQL 225
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 60.1 bits (144), Expect = 9e-09
Identities = 61/282 (21%), Positives = 110/282 (39%), Gaps = 33/282 (11%)
Query: 137 LGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQ 196
LG +L++LDGF F +N EG +++SE V+ YL +Q EL SV+ +H GDH E +
Sbjct: 115 LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKN 174
Query: 197 LGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
L LP + E ++ + + +P+ + DN + M+
Sbjct: 175 L---LPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEE--GHDNQEAHQKYETMQC 229
Query: 257 TLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRID 316
+ IK G + + RV + +PS
Sbjct: 230 FAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSS---------------------- 267
Query: 317 CHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHA----EDVEGIRHSHLDL 372
F TR ++ I + + + +RC HA E V + H ++
Sbjct: 268 -ESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEV 326
Query: 373 LNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNII 414
L +G ++ YR+ +G + Q+ + + I ++ NE ++
Sbjct: 327 LRQGLAFSQIYRFSLSDGTLVAAQTKSKL-IRSQTTNEPQLV 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,637,974
Number of Sequences: 37866
Number of extensions: 2096147
Number of successful extensions: 33599
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 440
Number of HSP's successfully gapped in prelim test: 672
Number of HSP's that attempted gapping in prelim test: 17120
Number of HSP's gapped (non-prelim): 9347
length of query: 920
length of database: 18,247,518
effective HSP length: 112
effective length of query: 808
effective length of database: 14,006,526
effective search space: 11317273008
effective search space used: 11317273008
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.