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Search of human proteins with 40254439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
(870 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 1779 0.0
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 612 e-175
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 609 e-174
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 403 e-112
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 402 e-112
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 335 1e-91
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 244 3e-64
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 244 3e-64
gi|21614542 single-minded homolog 1 [Homo sapiens] 243 7e-64
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 229 8e-60
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 223 6e-58
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 200 4e-51
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 144 3e-34
gi|4758010 clock [Homo sapiens] 138 2e-32
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 136 7e-32
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 136 7e-32
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 136 7e-32
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 136 1e-31
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 135 2e-31
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 135 2e-31
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 133 6e-31
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 107 5e-23
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 88 3e-17
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 78 3e-14
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 72 2e-12
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 68 3e-11
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 68 3e-11
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 67 5e-11
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 67 5e-11
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 67 5e-11
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 1779 bits (4609), Expect = 0.0
Identities = 870/870 (100%), Positives = 870/870 (100%)
Query: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
Sbjct: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
Query: 61 ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG 120
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
Sbjct: 61 ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG 120
Query: 121 LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG 180
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
Sbjct: 121 LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG 180
Query: 181 RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD 240
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
Sbjct: 181 RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD 240
Query: 241 SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG 300
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
Sbjct: 241 SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG 300
Query: 301 QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE 360
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
Sbjct: 301 QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE 360
Query: 361 SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN 420
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
Sbjct: 361 SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN 420
Query: 421 FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS 480
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
Sbjct: 421 FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS 480
Query: 481 TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF 540
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
Sbjct: 481 TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF 540
Query: 541 QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE 600
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
Sbjct: 541 QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE 600
Query: 601 HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE 660
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
Sbjct: 601 HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE 660
Query: 661 FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ 720
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
Sbjct: 661 FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ 720
Query: 721 DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL 780
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
Sbjct: 721 DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL 780
Query: 781 PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT 840
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
Sbjct: 781 PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT 840
Query: 841 RYDCEVNVPVLGSSTLLQGGDLLRALDQAT 870
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
Sbjct: 841 RYDCEVNVPVLGSSTLLQGGDLLRALDQAT 870
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 612 bits (1577), Expect = e-175
Identities = 377/834 (45%), Positives = 504/834 (60%), Gaps = 103/834 (12%)
Query: 6 EKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR 65
+KK+ SSERRKEKSRDAAR RRSKE+EVFYELAH+LPLPH+VSSHLDKAS+MRL IS+LR
Sbjct: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
Query: 66 THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVE 125
KLL + + E + +A QM+ YLKAL+GF+ V+T DGDMI++S+N++K+MGLTQ E
Sbjct: 69 VRKLLDAGDLDIEDDMKA--QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
Query: 126 LTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNL 185
LTGHS+FDFTHPCDHEE+RE L+ +NG KK K+ +T+R FF+RMKCT+T+RGRT+N+
Sbjct: 127 LTGHSVFDFTHPCDHEEMREMLTHRNG--LVKKGKEQNTQRSFFLRMKCTLTSRGRTMNI 184
Query: 186 KSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
KSATWKVLHCTG + VY+ + CGYK+P ++CL+++CEPI HPS+++IPLDSKTFL
Sbjct: 185 KSATWKVLHCTGHIHVYDT-NSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFL 243
Query: 246 SRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSG 305
SRHS+DMKF+YCD+RITEL+GY PEELLGRS YE+YHALDS+++TK+H ++ TKGQV +G
Sbjct: 244 SRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTG 303
Query: 306 QYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP 365
QYRMLAK GGYVW+ETQ TVIYN +N QPQCI+CVNYV+S I ++D++FS+ QTE + KP
Sbjct: 304 QYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
Query: 366 ---HLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFG----- 417
M M +F SE ++ LF KLK+EP+ L LAP GD IISLDFG
Sbjct: 364 VESSDMKMTQLFTK----VESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE 419
Query: 418 --NQNFEESSAYGKAILP----------------PSQPWATELRSHS----TQSEAGSLP 455
+Q EE Y +LP P+ LRS + Q A L
Sbjct: 420 TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLE 479
Query: 456 --------AFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDL----KIEVIEK 503
+FT+PQ + +PS S+ S PNSP +Y +D+D+ K+E++EK
Sbjct: 480 PNPESLELSFTMPQ-IQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEK 538
Query: 504 LFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQL---SPICPEERLLAENPQSTP 560
LFA DTEAK+ STQ +LDLE LAPYIPMD +DFQL + P E A ++P
Sbjct: 539 LFAEDTEAKNPFSTQD--TDLDLEMLAPYIPMD-DDFQLRSFDQLSPLESSSASPESASP 595
Query: 561 QHCFSA--MTNIFQPLA---PVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKA 615
Q + T I +P A + L + ++E K + I + S
Sbjct: 596 QSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSAT 655
Query: 616 SLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPH 675
S P Q+ T + G+ ++TE + P P V
Sbjct: 656 SSPYRDTQSRTASPNRAGKGVI-------------------EQTE--KSHPRSPNVLSVA 694
Query: 676 VSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGG-----DPPGG 730
+S T + L+P ++AL N + KR++E++ FQ + G
Sbjct: 695 LSQRTTVP--------EEELNPKILALQNAQR-KRKMEHDGSLFQAVGIGTLLQQPDDHA 745
Query: 731 STSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQ 784
+T+ L WKR+K + M K + +P+D R LG + LPQ
Sbjct: 746 ATTSLSWKRVKGCKSSEQNGMEQKTIIL-IPSDL----ACRLLGQSMDESGLPQ 794
Score = 63.2 bits (152), Expect = 1e-09
Identities = 31/49 (63%), Positives = 36/49 (73%)
Query: 820 SGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQ 868
S +A RLLG S + LP+LT YDCEVN P+ GS LLQG +LLRALDQ
Sbjct: 776 SDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQ 824
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 609 bits (1571), Expect = e-174
Identities = 333/617 (53%), Positives = 429/617 (69%), Gaps = 60/617 (9%)
Query: 6 EKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR 65
+KK+ SSERRKEKSRDAAR RRSKE+EVFYELAH+LPLPH+VSSHLDKAS+MRL IS+LR
Sbjct: 9 DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
Query: 66 THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVE 125
KLL + + E + +A QM+ YLKAL+GF+ V+T DGDMI++S+N++K+MGLTQ E
Sbjct: 69 VRKLLDAGDLDIEDDMKA--QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
Query: 126 LTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNL 185
LTGHS+FDFTHPCDHEE+RE L+ +NG KK K+ +T+R FF+RMKCT+T+RGRT+N+
Sbjct: 127 LTGHSVFDFTHPCDHEEMREMLTHRNG--LVKKGKEQNTQRSFFLRMKCTLTSRGRTMNI 184
Query: 186 KSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
KSATWKVLHCTG + VY+ + CGYK+P ++CL+++CEPI HPS+++IPLDSKTFL
Sbjct: 185 KSATWKVLHCTGHIHVYDT-NSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFL 243
Query: 246 SRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSG 305
SRHS+DMKF+YCD+RITEL+GY PEELLGRS YE+YHALDS+++TK+H ++ TKGQV +G
Sbjct: 244 SRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTG 303
Query: 306 QYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP 365
QYRMLAK GGYVW+ETQ TVIYN +N QPQCI+CVNYV+S I ++D++FS+ QTE + KP
Sbjct: 304 QYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
Query: 366 ---HLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFG----- 417
M M +F SE ++ LF KLK+EP+ L LAP GD IISLDFG
Sbjct: 364 VESSDMKMTQLFTK----VESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE 419
Query: 418 --NQNFEESSAYGKAILP----------------PSQPWATELRSHS----TQSEAGSLP 455
+Q EE Y +LP P+ LRS + Q A L
Sbjct: 420 TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLE 479
Query: 456 --------AFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDL----KIEVIEK 503
+FT+PQ + +PS S+ S PNSP +Y +D+D+ K+E++EK
Sbjct: 480 PNPESLELSFTMPQ-IQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEK 538
Query: 504 LFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQL---SPICPEERLLAENPQSTP 560
LFA DTEAK+ STQ +LDLE LAPYIPMD +DFQL + P E A ++P
Sbjct: 539 LFAEDTEAKNPFSTQD--TDLDLEMLAPYIPMD-DDFQLRSFDQLSPLESSSASPESASP 595
Query: 561 QHCFSA--MTNIFQPLA 575
Q + T I +P A
Sbjct: 596 QSTVTVFQQTQIQEPTA 612
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 403 bits (1035), Expect = e-112
Identities = 235/548 (42%), Positives = 328/548 (59%), Gaps = 50/548 (9%)
Query: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
M ++ RS++E RKEKSRDAAR RRS+ETEV Y+LAH LP VS+HLDKASIMRL
Sbjct: 1 MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLT 60
Query: 61 ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG 120
IS+LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+SK +G
Sbjct: 61 ISYLRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLG 118
Query: 121 LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG 180
L+Q+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+T+RG
Sbjct: 119 LSQLELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTLTSRG 176
Query: 181 RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSHMDIP 238
RT+NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP ++ P
Sbjct: 177 RTLNLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPP 235
Query: 239 LDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCT 298
L FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS L +
Sbjct: 236 LGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS 295
Query: 299 KGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQ 358
KGQ V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV S++Q
Sbjct: 296 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
Query: 359 TESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGN 418
TE + + +GA S+K P PGD++ +
Sbjct: 356 TEQHSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTPGPRI 388
Query: 419 QNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSS 478
F + +A L A + R + L + A +TP AT S
Sbjct: 389 LAFLHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQS 442
Query: 479 CSTPNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAPYIPM 535
+ + P++ +N + +LF DTEA + D + LDLE LAPYI M
Sbjct: 443 PLSADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISM 496
Query: 536 DGEDFQLS 543
D +DFQL+
Sbjct: 497 D-DDFQLN 503
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 402 bits (1034), Expect = e-112
Identities = 235/545 (43%), Positives = 327/545 (60%), Gaps = 50/545 (9%)
Query: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
D + RS++E RKEKSRDAAR RRS+ETEV Y+LAH LP VS+HLDKASIMRL IS+
Sbjct: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
Query: 64 LRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQ 123
LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+SK +GL+Q
Sbjct: 62 LRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 119
Query: 124 VELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTV 183
+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+T+RGRT+
Sbjct: 120 LELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTLTSRGRTL 177
Query: 184 NLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSHMDIPLDS 241
NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP ++ PL
Sbjct: 178 NLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGR 236
Query: 242 KTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQ 301
FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS L +KGQ
Sbjct: 237 GAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQ 296
Query: 302 VVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTES 361
V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV S++QTE
Sbjct: 297 AVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQ 356
Query: 362 LFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNF 421
+ + +GA S+K P PGD++ + F
Sbjct: 357 HSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTPGPRILAF 389
Query: 422 EESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCST 481
+ +A L A + R + L + A +TP AT S +
Sbjct: 390 LHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLS 443
Query: 482 PNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAPYIPMDGE 538
+ P++ +N + +LF DTEA + D + LDLE LAPYI MD +
Sbjct: 444 ADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMD-D 496
Query: 539 DFQLS 543
DFQL+
Sbjct: 497 DFQLN 501
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 335 bits (858), Expect = 1e-91
Identities = 199/492 (40%), Positives = 285/492 (57%), Gaps = 50/492 (10%)
Query: 57 MRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENIS 116
MRL IS+LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+S
Sbjct: 1 MRLTISYLRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVS 58
Query: 117 KFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTV 176
K +GL+Q+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+
Sbjct: 59 KHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTL 116
Query: 177 TNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSH 234
T+RGRT+NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP
Sbjct: 117 TSRGRTLNLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGS 175
Query: 235 MDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQ 294
++ PL FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS
Sbjct: 176 LEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH 235
Query: 295 NLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVF 354
L +KGQ V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV
Sbjct: 236 TLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVL 295
Query: 355 SMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISL 414
S++QTE + + +GA S+K P PGD++ +
Sbjct: 296 SLEQTEQHSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTP 328
Query: 415 DFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATS 474
F + +A L A + R + L + A +TP AT
Sbjct: 329 GPRILAFLHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATR 382
Query: 475 SSSSCSTPNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAP 531
S + + P++ +N + +LF DTEA + D + LDLE LAP
Sbjct: 383 HPQSPLSADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAP 436
Query: 532 YIPMDGEDFQLS 543
YI MD +DFQL+
Sbjct: 437 YISMD-DDFQLN 447
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 244 bits (623), Expect = 3e-64
Identities = 149/461 (32%), Positives = 244/461 (52%), Gaps = 39/461 (8%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
KEKS++AA+ RR KE FYELA LPLP +++S LDKASI+RL S+L+ +
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 76 ENESEAEADQQMDNL-------YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTG 128
+ + +D + L+ L+GF+ VV DG ++++SE S +GL+QVELTG
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
Query: 129 HSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSA 188
+SI+++ HP DH+E+ L+ ++ ER FF+RMKC + R L +
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRN--AGLTCS 178
Query: 189 TWKVLHCTGQVKV---------YNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPL 239
+KV+HC+G +K+ Y++C Y+ + L+ + + + + +I L
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLYDSC--------YQ---IVGLVAVGQSLPPSAITEIKL 227
Query: 240 DSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTK 299
S F+ R S+D+K + D R+TE+ GY P++L+ ++ Y H D ++ +H L K
Sbjct: 228 YSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK 287
Query: 300 GQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQT 359
GQV + YR+L+K GG+VW+++ TV++N R+ +P CI+ VNYVL+EIE ++ S++Q
Sbjct: 288 GQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
Query: 360 ESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQ 419
+ + V K+ + TKL+ P Q + D + GN
Sbjct: 348 STAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNW 407
Query: 420 NFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVP 460
+S A PP EL+ HS S+ P++++P
Sbjct: 408 ---RASPPASAAAPP------ELQPHSESSDLLYTPSYSLP 439
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 244 bits (623), Expect = 3e-64
Identities = 149/461 (32%), Positives = 244/461 (52%), Gaps = 39/461 (8%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
KEKS++AA+ RR KE FYELA LPLP +++S LDKASI+RL S+L+ +
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 76 ENESEAEADQQMDNL-------YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTG 128
+ + +D + L+ L+GF+ VV DG ++++SE S +GL+QVELTG
Sbjct: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
Query: 129 HSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSA 188
+SI+++ HP DH+E+ L+ ++ ER FF+RMKC + R L +
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRN--AGLTCS 178
Query: 189 TWKVLHCTGQVKV---------YNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPL 239
+KV+HC+G +K+ Y++C Y+ + L+ + + + + +I L
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLYDSC--------YQ---IVGLVAVGQSLPPSAITEIKL 227
Query: 240 DSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTK 299
S F+ R S+D+K + D R+TE+ GY P++L+ ++ Y H D ++ +H L K
Sbjct: 228 YSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK 287
Query: 300 GQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQT 359
GQV + YR+L+K GG+VW+++ TV++N R+ +P CI+ VNYVL+EIE ++ S++Q
Sbjct: 288 GQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
Query: 360 ESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQ 419
+ + V K+ + TKL+ P Q + D + GN
Sbjct: 348 STAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNW 407
Query: 420 NFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVP 460
+S A PP EL+ HS S+ P++++P
Sbjct: 408 ---RASPPASAAAPP------ELQPHSESSDLLYTPSYSLP 439
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 243 bits (619), Expect = 7e-64
Identities = 139/382 (36%), Positives = 215/382 (56%), Gaps = 16/382 (4%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
KEKS++AAR RR KE FYELA LPLP +++S LDKASI+RL S+L+ +
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 76 ENESEAEADQQMDNL-------YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTG 128
E + +DN+ L+ L+GFI VV DG ++++SE S +GL+QVELTG
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
Query: 129 HSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSA 188
+SI+++ HP DH+E+ L+ ++ ER FF+RMKC + R L
Sbjct: 122 NSIYEYIHPADHDEMTAVLTAHQPY-HSHFVQEYEIERSFFLRMKCVLAKRN--AGLTCG 178
Query: 189 TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRH 248
+KV+HC+G +K+ + G + + L+ + + + +I L S F+ R
Sbjct: 179 GYKVIHCSGYLKIRQYSLDMSPFDGCYQNV--GLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
Query: 249 SMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYR 308
S+DMK + D R+ EL GY P++L+ ++ Y H D+ ++ +H L KGQV + YR
Sbjct: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
Query: 309 MLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP--- 365
LAKHGG+VW+++ T+++N R+ +P CI+ VNYVL++ E + S+DQ S KP
Sbjct: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI-SASKPAFS 355
Query: 366 HLMAMNSIFDSSGKGAVSEKSN 387
+ + + KGA S S+
Sbjct: 356 YTSSSTPTMTDNRKGAKSRLSS 377
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 229 bits (584), Expect = 8e-60
Identities = 137/420 (32%), Positives = 221/420 (52%), Gaps = 67/420 (15%)
Query: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
D ++ RKEKSRDAAR RR KE FYELA LPLP +++S LDKASI+RL IS+
Sbjct: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
Query: 64 LRTHKLLS-----------------SVCSENESEAEA-------DQQMDNLYLKALEGFI 99
L+ + SV + + + + + L++L+GF+
Sbjct: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 130
Query: 100 AVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKS 159
+ Q+G +++SE +S ++GL+QVELTG S+FD+ HP DH E+ E L +K G G S
Sbjct: 131 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 190
Query: 160 K--------------------------------DMSTERDFFMRMKCTVTNRGRTVNLKS 187
+ D + ER FF+RMK T+T RG V++KS
Sbjct: 191 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKS 248
Query: 188 ATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSR 247
+ +KV+H TG++++ + ++ + L+++ + P+ ++ +D F++R
Sbjct: 249 SGYKVIHITGRLRLRVSLSHGRTVPSQ----IMGLVVVAHALPPPTINEVRIDCHMFVTR 304
Query: 248 HSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQY 307
+MD+ YC++RI++ + P +++G+ Y F HA D E + SH +L KGQ V+ Y
Sbjct: 305 VNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYY 364
Query: 308 RMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHL 367
R + K+GGY+W+++ T+ N +N + I+ VNY+LS E D + Q PHL
Sbjct: 365 RWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL-----PHL 419
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 223 bits (568), Expect = 6e-58
Identities = 138/439 (31%), Positives = 222/439 (50%), Gaps = 86/439 (19%)
Query: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
D ++ RKEKSRDAAR RR KE FYELA LPLP +++S LDKASI+RL IS+
Sbjct: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
Query: 64 LRTHKLL---------------------------SSVC----------SENESEAEA--- 83
L+ S +C ++ A
Sbjct: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAI 130
Query: 84 ---DQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDH 140
+ + + L++L+GF+ + Q+G +++SE +S ++GL+QVELTG S+FD+ HP DH
Sbjct: 131 EVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDH 190
Query: 141 EEIRENLSLKNGSGFGKKSK--------------------------------DMSTERDF 168
E+ E L +K G G S+ D + ER F
Sbjct: 191 VEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSF 250
Query: 169 FMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEP 228
F+RMK T+T RG V++KS+ +KV+H TG++++ + ++ + L+++
Sbjct: 251 FIRMKSTLTKRG--VHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQ----IMGLVVVAHA 304
Query: 229 IQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSEN 288
+ P+ ++ +D F++R +MD+ YC++RI++ + P +++G+ Y F HA D E
Sbjct: 305 LPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEG 364
Query: 289 MTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIE 348
+ SH +L KGQ V+ YR + K+GGY+W+++ T+ N +N + I+ VNY+LS E
Sbjct: 365 IRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPE 424
Query: 349 KNDVVFSMDQTESLFKPHL 367
D + Q PHL
Sbjct: 425 YKDTPMDIAQL-----PHL 438
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 200 bits (509), Expect = 4e-51
Identities = 121/383 (31%), Positives = 201/383 (52%), Gaps = 66/383 (17%)
Query: 14 RRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSV 73
+RKEKSR+AAR RR KE F+ELA LPLP ++SS LDKASI+RL++++LR + +
Sbjct: 45 QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104
Query: 74 CSENESEAEA--------------------DQQMDNLYLKALEGFIAVVTQDGDMIFLSE 113
A +Q + L++L+GF+ + Q+G +++SE
Sbjct: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164
Query: 114 NISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS-------GFGKKSKDMST-- 164
+S ++GL+QVE+TG S+FD+ HP DH E+ E L L+ + S S+
Sbjct: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224
Query: 165 -------------------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNC 205
ER FF+RMK T+T RG +++K++ +KV+H TG+++ +
Sbjct: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAH--- 279
Query: 206 PPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELI 265
L+ + + ++PL + R S+ + C+ R+++ +
Sbjct: 280 -------------ALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
Query: 266 GYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTV 325
P EL+GRS Y+F H D+ + +SH +L KGQV++G YR L + GG+VWL++ TV
Sbjct: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
Query: 326 IYNPRNLQPQCIMCVNYVLSEIE 348
+ ++ ++ V++VLS+ E
Sbjct: 387 AGSGKSPGEHHVLWVSHVLSQAE 409
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 144 bits (364), Expect = 3e-34
Identities = 111/380 (29%), Positives = 189/380 (49%), Gaps = 46/380 (12%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSS--V 73
+E + RR K + EL+ +P + ++ LDK +++R+A+ LR+ K L++ V
Sbjct: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYV 168
Query: 74 CSENESEAEADQQMDNLYLKALEGFIAVV-TQDGDMIFLSENISKFMGLTQVELTGHSIF 132
S D ++ +L LK EGF+ VV + G ++F+S+++SK + Q LTG S+F
Sbjct: 169 GSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLF 228
Query: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMK- 173
DF HP D +++E LS + + G+ + R FF R+K
Sbjct: 229 DFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKS 288
Query: 174 CTVT---NRGRTVNLKSATWK---VLHCTGQVKVYNNCPPHNSLCGYKEPLLS------- 220
C ++ G N K + +HCTG ++ + PP+ + G +E S
Sbjct: 289 CKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSW---PPN--IVGMEEERNSKKDNSNF 343
Query: 221 -CLIIM--CEPIQHPSHM-DIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRS 276
CL+ + +P P + +I + F++R +++ KF Y D R T ++GY P+ELLG S
Sbjct: 344 TCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTS 403
Query: 277 AYEFYHALDSENMTKSHQN-LCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQ 335
YE++H D N+T H+ L +K ++++ Y+ AK G +V L++Q NP + +
Sbjct: 404 CYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELE 463
Query: 336 CIMCVN-YVLSEIEKNDVVF 354
I+ VN VL E + F
Sbjct: 464 YIVSVNTLVLGHSEPGEASF 483
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 138 bits (348), Expect = 2e-32
Identities = 99/365 (27%), Positives = 173/365 (47%), Gaps = 34/365 (9%)
Query: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
DK+K + S + EK R R + + EL LP + +DK+++++ +I F
Sbjct: 30 DKDKAKRVSRNKSEKKR------RDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDF 80
Query: 64 LRTHKLLSSVCSENESEAE------ADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISK 117
LR HK +++ +E + ++++ L L+AL+GF + DG +I++SE+++
Sbjct: 81 LRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTS 140
Query: 118 FMGLTQVELTGHSIFDFTHPCDHEEIRENLS--LKNGSGFGKKSKDMSTERDFFMRMKCT 175
+ +L SIF+F +H E+ + LS L + + +F C
Sbjct: 141 LLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEF-----CC 195
Query: 176 VTNRGRTVNLKSATWKVLHCTGQVKVYNNCPP--HNSLCG---------YKEPLLSCLII 224
RG + +T++ + G K N+ HN G Y++ + +
Sbjct: 196 HMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATV 255
Query: 225 MCEPIQHPSHM-DIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHA 283
Q M + ++ F SRHS++ KF + D R +IGY P E+LG S Y++YH
Sbjct: 256 RLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHV 315
Query: 284 LDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYV 343
D EN+ K H++L G+ S YR L K ++WL+T + Y+ N +P+ I+C + V
Sbjct: 316 DDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375
Query: 344 LSEIE 348
+S E
Sbjct: 376 VSYAE 380
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 136 bits (343), Expect = 7e-32
Identities = 105/384 (27%), Positives = 186/384 (48%), Gaps = 50/384 (13%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
+E + RR K ELA +P +++S LDK +++R+A+ ++T + ++ +
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
Query: 76 ENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIF 132
E + +D ++ +L L+A +GF+ VV D G ++F+SE++ K + +Q +L G S+F
Sbjct: 91 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 150
Query: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMKC 174
D+ HP D +++E LS +K G R FF RMKC
Sbjct: 151 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 210
Query: 175 T-----VTNRG--RTVNLKS--ATWKVLHCTGQVKVY--------NNCPPHNSLCGYKEP 217
V ++ T + K ++ +H TG +K + + P N C
Sbjct: 211 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN---- 266
Query: 218 LLSCLIIMCEPIQH----PSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELL 273
LSCL+ + H P + +I + S ++SRH++D KF + D R T ++ Y P+ELL
Sbjct: 267 -LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELL 325
Query: 274 GRSAYEFYHALDSENMTKSH-QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNL 332
G S YE++H D ++ + H Q L T+ ++ + Y+ K G ++ L ++ NP
Sbjct: 326 GTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTK 385
Query: 333 QPQCIMCVNYVL--SEIEKNDVVF 354
+ + I+ N V+ + +E D F
Sbjct: 386 EVEYIVSTNTVVLANVLEGGDPTF 409
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 136 bits (343), Expect = 7e-32
Identities = 105/384 (27%), Positives = 186/384 (48%), Gaps = 50/384 (13%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
+E + RR K ELA +P +++S LDK +++R+A+ ++T + ++ +
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 76 ENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIF 132
E + +D ++ +L L+A +GF+ VV D G ++F+SE++ K + +Q +L G S+F
Sbjct: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
Query: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMKC 174
D+ HP D +++E LS +K G R FF RMKC
Sbjct: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
Query: 175 T-----VTNRG--RTVNLKS--ATWKVLHCTGQVKVY--------NNCPPHNSLCGYKEP 217
V ++ T + K ++ +H TG +K + + P N C
Sbjct: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN---- 309
Query: 218 LLSCLIIMCEPIQH----PSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELL 273
LSCL+ + H P + +I + S ++SRH++D KF + D R T ++ Y P+ELL
Sbjct: 310 -LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELL 368
Query: 274 GRSAYEFYHALDSENMTKSH-QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNL 332
G S YE++H D ++ + H Q L T+ ++ + Y+ K G ++ L ++ NP
Sbjct: 369 GTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTK 428
Query: 333 QPQCIMCVNYVL--SEIEKNDVVF 354
+ + I+ N V+ + +E D F
Sbjct: 429 EVEYIVSTNTVVLANVLEGGDPTF 452
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 136 bits (343), Expect = 7e-32
Identities = 105/384 (27%), Positives = 186/384 (48%), Gaps = 50/384 (13%)
Query: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
+E + RR K ELA +P +++S LDK +++R+A+ ++T + ++ +
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 76 ENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIF 132
E + +D ++ +L L+A +GF+ VV D G ++F+SE++ K + +Q +L G S+F
Sbjct: 134 EANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLF 193
Query: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMKC 174
D+ HP D +++E LS +K G R FF RMKC
Sbjct: 194 DYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKC 253
Query: 175 T-----VTNRG--RTVNLKS--ATWKVLHCTGQVKVY--------NNCPPHNSLCGYKEP 217
V ++ T + K ++ +H TG +K + + P N C
Sbjct: 254 NRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN---- 309
Query: 218 LLSCLIIMCEPIQH----PSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELL 273
LSCL+ + H P + +I + S ++SRH++D KF + D R T ++ Y P+ELL
Sbjct: 310 -LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELL 368
Query: 274 GRSAYEFYHALDSENMTKSH-QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNL 332
G S YE++H D ++ + H Q L T+ ++ + Y+ K G ++ L ++ NP
Sbjct: 369 GTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTK 428
Query: 333 QPQCIMCVNYVL--SEIEKNDVVF 354
+ + I+ N V+ + +E D F
Sbjct: 429 EVEYIVSTNTVVLANVLEGGDPTF 452
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 136 bits (342), Expect = 1e-31
Identities = 106/407 (26%), Positives = 187/407 (45%), Gaps = 45/407 (11%)
Query: 1 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA 60
M D E S+ +E + R RR+K T+ EL+ +P +++ DK +I+R+A
Sbjct: 50 MDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMA 109
Query: 61 ISFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISK 117
+S +++ + + ++ + +Q++ +L L+A +GF+ VV + G +I++S++++
Sbjct: 110 VSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTP 169
Query: 118 FMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFG----------KKSKD------ 161
+ Q E G ++++ HP D E++RE L S G KK
Sbjct: 170 VLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRM 229
Query: 162 -MSTERDFFMRMKC--------------TVTNRGRT----VNLKSATWKVLHCTGQVKVY 202
M + R F RM+C T+ R R V A + V+HCTG +K +
Sbjct: 230 CMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW 289
Query: 203 N----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDS--KTFLSRHSMDMKFTY 256
P ++ G I + P MD+ S FLSRH+ D T+
Sbjct: 290 PPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITF 349
Query: 257 CDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHGG 315
D R +IGY P++LLG+ EF H D ++ +S Q + KGQV+S YR K+
Sbjct: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409
Query: 316 YVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESL 362
++ + T NP + + + I+C N + ++++ + Q + L
Sbjct: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGL 456
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 135 bits (339), Expect = 2e-31
Identities = 133/556 (23%), Positives = 232/556 (41%), Gaps = 87/556 (15%)
Query: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
+K++ + +S + EK R R + + EL+ LP + +DK +++ I F
Sbjct: 5 EKDRAKRASRNKSEKKR------RDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55
Query: 64 LRTHKLLSS---VCSENESEAEA---DQQMDNLYLKALEGFIAVVTQDGDMIFLSENISK 117
L+ H +S+ +C + + +++ L L+AL+GFI VT DG +I++S++I+
Sbjct: 56 LQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITP 115
Query: 118 FMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVT 177
+G ++ ++ +F +H E+ + LS + + ++ D + C +
Sbjct: 116 LLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSD--LEFYCHLL 173
Query: 178 NRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY-------------KEPLLSCLII 224
RG + T++ + G + YNN P S G+ KE +
Sbjct: 174 -RGSLNPKEFPTYEYIKFVGNFRSYNNVPSP-SCNGFDNTLSRPCRVPLGKEVCFIATVR 231
Query: 225 MCEP--IQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYH 282
+ P ++ +D PL+ F SRHS++ KF + D R +IGY P E+LG S Y++YH
Sbjct: 232 LATPQFLKEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH 289
Query: 283 ALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNY 342
D E + + HQ+L G+ S YR L K ++WL+T + Y+ N +P+ I+C +
Sbjct: 290 IDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHS 349
Query: 343 VLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQ 402
V+S DV Q +L P A++S A+ +K + L
Sbjct: 350 VVSYA---DVRVERRQELALEDPPSEALHS-------SALKDKGSSL------------- 386
Query: 403 LAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQA 462
P +LD G S + P + ++ SH+ SE S P + +A
Sbjct: 387 ---EPRQHFNTLDVGASGLNTSHS------PSASSRSSHKSSHTAMSEPTSTPTKLMAEA 437
Query: 463 AAP-------------------GSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEK 503
+ P +T P+ S SSC +
Sbjct: 438 STPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSA 497
Query: 504 LFAMDTEAKDQCSTQT 519
F+M KDQ +T
Sbjct: 498 QFSMFQTIKDQLEQRT 513
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 135 bits (339), Expect = 2e-31
Identities = 100/385 (25%), Positives = 183/385 (47%), Gaps = 46/385 (11%)
Query: 3 ADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAI 61
+D E+ + ER +E + R RR+K T EL+ +P +++ DK +I+R+A+
Sbjct: 77 SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
Query: 62 SFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENISKF 118
S +++ + + ++ + DQ++ +L L+A +GF+ +V+ + G ++++S++++
Sbjct: 137 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 196
Query: 119 MGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS----------GFGKKSKD------- 161
+ Q E G +++D HP D +++RE LS + G KK
Sbjct: 197 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 256
Query: 162 MSTERDFFMRMKCT--------------VTNRGR----TVNLKSATWKVLHCTGQVKVYN 203
M + R F RM+C V NR R +V + V+HCTG +K +
Sbjct: 257 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 316
Query: 204 ----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIP--LDSKTFLSRHSMDMKFTYC 257
+ P + G I + P+ D+ F+SRH+++ FT+
Sbjct: 317 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376
Query: 258 DDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHGGY 316
D R +GY P+ELLG++ EF H D + + S Q + KGQV+S +R +K+ +
Sbjct: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
Query: 317 VWLETQGTVIYNPRNLQPQCIMCVN 341
+W+ T NP + + + I+C N
Sbjct: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 133 bits (335), Expect = 6e-31
Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 46/387 (11%)
Query: 1 MTADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRL 59
+ D ++ + ER +E + R RR+K T EL+ +P +++ DK +I+R+
Sbjct: 60 LRCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRM 119
Query: 60 AISFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENIS 116
A+S +++ + + ++ + DQ++ +L L+A +GF+ +V+ + G ++++S++++
Sbjct: 120 AVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVT 179
Query: 117 KFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS----------GFGKKSKD----- 161
+ Q E G +++D HP D +++RE LS + G KK
Sbjct: 180 PVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMR 239
Query: 162 --MSTERDFFMRMKCT--------------VTNRGR----TVNLKSATWKVLHCTGQVKV 201
M + R F RM+C V NR R +V + V+HCTG +K
Sbjct: 240 MCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKA 299
Query: 202 YN----NCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIP--LDSKTFLSRHSMDMKFT 255
+ + P + G I + P+ D+ F+SRH+++ FT
Sbjct: 300 WPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359
Query: 256 YCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLC-TKGQVVSGQYRMLAKHG 314
+ D R +GY P+ELLG++ EF H D + + S Q + KGQV+S +R +K+
Sbjct: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419
Query: 315 GYVWLETQGTVIYNPRNLQPQCIMCVN 341
++W+ T NP + + + I+C N
Sbjct: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 107 bits (267), Expect = 5e-23
Identities = 91/371 (24%), Positives = 157/371 (42%), Gaps = 52/371 (14%)
Query: 18 KSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSEN 77
KS + R R TE+ LA LP P V + LDK S++RL++S+LR +
Sbjct: 32 KSNPSKRHRDRLNTELD-RLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
Query: 78 ESEAEADQ--------------QMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQ 123
+E Q Q L+AL GF+ VVT D + + S I ++G Q
Sbjct: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
Query: 124 VELTGHSIFDFTHPCDHEEIRENLS--------LKNGSGFGKKSKDMST----------- 164
++ S+++ H D E + L ++G G + + T
Sbjct: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
Query: 165 ------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPL 218
ER F R++C + N S+ + ++ G++K + P
Sbjct: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQ 262
Query: 219 LSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGR-SA 277
L+ L + P+Q PS ++I + F ++H +D CD + ++GY EL R S
Sbjct: 263 LA-LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSG 321
Query: 278 YEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCI 337
Y+F HA D +SH + G+ +R+L K+ + W+++ ++Y +N +P I
Sbjct: 322 YQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYI 379
Query: 338 MCVNYVLSEIE 348
+ L++ E
Sbjct: 380 IVTQRPLTDEE 390
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 88.2 bits (217), Expect = 3e-17
Identities = 84/339 (24%), Positives = 150/339 (44%), Gaps = 34/339 (10%)
Query: 19 SRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS-EN 77
++ A++ RR + L LPL + L IM LA + R +
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
Query: 78 ESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELT--GHSIFDFT 135
+ + Q+++++ + AL GF+ V T +G +++LSE++S+ +G + V+L G SI+D
Sbjct: 65 PTGLLSAQELEDI-VAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
Query: 136 HPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHC 195
P DH +R+ L+L + + T+R F R N +++ +SA K++
Sbjct: 124 DPADHLTVRQQLTLPSA---------LDTDRLFRCRF-----NTSKSLRRQSAGNKLVLI 169
Query: 196 TGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL----SRHSMD 251
G+ + PP G P+ + EP P P + FL SRH+ D
Sbjct: 170 RGRFHAH---PPGAYWAG--NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKD 224
Query: 252 MKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQ--YRM 309
+ + + +G+ ELL +S Y H D + + H L + + + R+
Sbjct: 225 LALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRL 284
Query: 310 LAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIE 348
AK GG+ W+ ++Y+ P I NY +S++E
Sbjct: 285 QAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDME 318
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/239 (25%), Positives = 119/239 (49%), Gaps = 39/239 (16%)
Query: 3 ADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAI 61
+D E+ + ER +E + R RR+K T EL+ +P +++ DK +I+R+A+
Sbjct: 77 SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
Query: 62 SFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENISKF 118
S +++ + + ++ + DQ++ +L L+A +GF+ +V+ + G ++++S++++
Sbjct: 137 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 196
Query: 119 MGLTQVELTGHSIFDFTHPCDHEEIRENLS------------LKNGS--GFGKKSK---D 161
+ Q E G +++D HP D +++RE LS LK G+ G++S
Sbjct: 197 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 256
Query: 162 MSTERDFFMRMKC--------------TVTNRGR----TVNLKSATWKVLHCTGQVKVY 202
M + R F RM+C V NR R +V + V+HCTG +K +
Sbjct: 257 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 72.4 bits (176), Expect = 2e-12
Identities = 87/396 (21%), Positives = 165/396 (41%), Gaps = 47/396 (11%)
Query: 6 EKKRSSSERRKE--------KSRDAARCRRSKETEVFYELAHELPLPHSVSSHL----DK 53
+ R+ + +RKE R+ + R +E + ELA + + + DK
Sbjct: 10 DPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDK 69
Query: 54 ASIMRLAISFLRTHKLLSSVCSENESEAEADQ------------QMDNLYLKALEGFIAV 101
+I++ + +R K + N E + + + L+AL+GF V
Sbjct: 70 CAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFV 129
Query: 102 VTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKN----GSGFGK 157
V +G+++F+SEN+++++ Q EL S++ H DH E +NL K+ GS G+
Sbjct: 130 VNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGE 189
Query: 158 KSKDMSTERDFFMRMKCTVTN--RGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYK 215
+ S + M +K + G ++ + C S+
Sbjct: 190 PPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA-------VSQPKSIKEEG 242
Query: 216 EPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHP--EELL 273
E L SCLI + + +P S++F +R + K T D T P E+L+
Sbjct: 243 EDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRAAMKPGWEDLV 300
Query: 274 GRSAYEFYHALDSENMT---KSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPR 330
R +F+ + E+++ + H + +G S YR G V +T+ +I +
Sbjct: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
Query: 331 NLQPQCIMCVNYVLSEIEKNDVVFSMDQT-ESLFKP 365
+PQ ++ ++ + E+N V + D T +++ KP
Sbjct: 361 TNEPQLVISLH--MLHREQNVCVMNPDLTGQTMGKP 394
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/337 (21%), Positives = 140/337 (41%), Gaps = 51/337 (15%)
Query: 26 RRSKETEVFYELAHELPLPHSVSSHL----DKASIMRLAISFLRTHKLLSSVCSENESEA 81
RR +E++ ELA + S + DK +I++ + +R K S ++
Sbjct: 37 RREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQ 96
Query: 82 EAD-----------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHS 130
+AD + L L+AL+GF+ VV +DG+++F+SEN+++++ Q +L S
Sbjct: 97 KADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTS 156
Query: 131 IFDFTHPCDHEEIRENL--SLKNGSGFGKKSKD-----------MSTERDFFMRMKCTVT 177
+++ H D ++ +NL S NG + +++ M T D + +
Sbjct: 157 VYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPE 216
Query: 178 NRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDI 237
R R ++ + C ++ E L SC+I + I
Sbjct: 217 MRQR--------YETMQCFA-------LSQPRAMMEEGEDLQSCMICVARRIT-TGERTF 260
Query: 238 PLDSKTFLSRHSMDMKFTYCDD---RITELIGYHPEELLGRSAYEFYHALDSENMT--KS 292
P + ++F++RH + K D R + G+ E+++ R F+ D ++ + +
Sbjct: 261 PSNPESFITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRH 318
Query: 293 HQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNP 329
+Q G + YR G V +T+ + NP
Sbjct: 319 YQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/337 (21%), Positives = 140/337 (41%), Gaps = 51/337 (15%)
Query: 26 RRSKETEVFYELAHELPLPHSVSSHL----DKASIMRLAISFLRTHKLLSSVCSENESEA 81
RR +E++ ELA + S + DK +I++ + +R K S ++
Sbjct: 37 RREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQ 96
Query: 82 EAD-----------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHS 130
+AD + L L+AL+GF+ VV +DG+++F+SEN+++++ Q +L S
Sbjct: 97 KADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTS 156
Query: 131 IFDFTHPCDHEEIRENL--SLKNGSGFGKKSKD-----------MSTERDFFMRMKCTVT 177
+++ H D ++ +NL S NG + +++ M T D + +
Sbjct: 157 VYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPE 216
Query: 178 NRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDI 237
R R ++ + C ++ E L SC+I + I
Sbjct: 217 MRQR--------YETMQCFA-------LSQPRAMMEEGEDLQSCMICVARRIT-TGERTF 260
Query: 238 PLDSKTFLSRHSMDMKFTYCDD---RITELIGYHPEELLGRSAYEFYHALDSENMT--KS 292
P + ++F++RH + K D R + G+ E+++ R F+ D ++ + +
Sbjct: 261 PSNPESFITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRH 318
Query: 293 HQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNP 329
+Q G + YR G V +T+ + NP
Sbjct: 319 YQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 67.4 bits (163), Expect = 5e-11
Identities = 75/325 (23%), Positives = 135/325 (41%), Gaps = 34/325 (10%)
Query: 26 RRSKETEVFYELAHELPLP----HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEA 81
RR +E + ELA L S+S DK I++ + ++ K + S + +
Sbjct: 35 RREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDV 94
Query: 82 EAD------------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGH 129
+ + + L L+AL+GF VV +G ++F+SEN++ ++G Q EL
Sbjct: 95 QKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNT 154
Query: 130 SIFDFTHPCDHEEIRENL---SLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLK 186
S++ H DH E +NL SL NG + +++ ++ F RM + T N +
Sbjct: 155 SVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS-HTFNCRMLIHPPDEPGTENQE 213
Query: 187 SA-TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
+ ++V+ C + P S+ E SCLI + + P + ++F+
Sbjct: 214 ACQRYEVMQC------FTVSQP-KSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFM 263
Query: 246 SRHSMDMKFTYCDDRITELIGYHP-EELLGRSAYEFYHALDSE--NMTKSHQNLCTKGQV 302
++ K D G E+L+ + Y F+ E + Q + T+G
Sbjct: 264 TKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTA 323
Query: 303 VSGQYRMLAKHGGYVWLETQGTVIY 327
S YR + G + T+ + Y
Sbjct: 324 SSPSYRFILNDGTMLSAHTKCKLCY 348
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 67.4 bits (163), Expect = 5e-11
Identities = 75/325 (23%), Positives = 135/325 (41%), Gaps = 34/325 (10%)
Query: 26 RRSKETEVFYELAHELPLP----HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEA 81
RR +E + ELA L S+S DK I++ + ++ K + S + +
Sbjct: 35 RREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDV 94
Query: 82 EAD------------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGH 129
+ + + L L+AL+GF VV +G ++F+SEN++ ++G Q EL
Sbjct: 95 QKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNT 154
Query: 130 SIFDFTHPCDHEEIRENL---SLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLK 186
S++ H DH E +NL SL NG + +++ ++ F RM + T N +
Sbjct: 155 SVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS-HTFNCRMLIHPPDEPGTENQE 213
Query: 187 SA-TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
+ ++V+ C + P S+ E SCLI + + P + ++F+
Sbjct: 214 ACQRYEVMQC------FTVSQP-KSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFM 263
Query: 246 SRHSMDMKFTYCDDRITELIGYHP-EELLGRSAYEFYHALDSE--NMTKSHQNLCTKGQV 302
++ K D G E+L+ + Y F+ E + Q + T+G
Sbjct: 264 TKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTA 323
Query: 303 VSGQYRMLAKHGGYVWLETQGTVIY 327
S YR + G + T+ + Y
Sbjct: 324 SSPSYRFILNDGTMLSAHTKCKLCY 348
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 67.4 bits (163), Expect = 5e-11
Identities = 75/325 (23%), Positives = 135/325 (41%), Gaps = 34/325 (10%)
Query: 26 RRSKETEVFYELAHELPLP----HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEA 81
RR +E + ELA L S+S DK I++ + ++ K + S + +
Sbjct: 35 RREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDV 94
Query: 82 EAD------------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGH 129
+ + + L L+AL+GF VV +G ++F+SEN++ ++G Q EL
Sbjct: 95 QKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNT 154
Query: 130 SIFDFTHPCDHEEIRENL---SLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLK 186
S++ H DH E +NL SL NG + +++ ++ F RM + T N +
Sbjct: 155 SVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS-HTFNCRMLIHPPDEPGTENQE 213
Query: 187 SA-TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
+ ++V+ C + P S+ E SCLI + + P + ++F+
Sbjct: 214 ACQRYEVMQC------FTVSQP-KSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFM 263
Query: 246 SRHSMDMKFTYCDDRITELIGYHP-EELLGRSAYEFYHALDSE--NMTKSHQNLCTKGQV 302
++ K D G E+L+ + Y F+ E + Q + T+G
Sbjct: 264 TKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTA 323
Query: 303 VSGQYRMLAKHGGYVWLETQGTVIY 327
S YR + G + T+ + Y
Sbjct: 324 SSPSYRFILNDGTMLSAHTKCKLCY 348
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,651,267
Number of Sequences: 37866
Number of extensions: 1926950
Number of successful extensions: 8608
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 8075
Number of HSP's gapped (non-prelim): 506
length of query: 870
length of database: 18,247,518
effective HSP length: 111
effective length of query: 759
effective length of database: 14,044,392
effective search space: 10659693528
effective search space used: 10659693528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.