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Search of human proteins with 38570142
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 1352 0.0
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 396 e-110
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 357 2e-98
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 348 1e-95
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 340 2e-93
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 308 1e-83
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 307 2e-83
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 302 8e-82
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 294 2e-79
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 273 3e-73
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 214 3e-55
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 214 3e-55
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 207 3e-53
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 206 6e-53
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 201 1e-51
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 201 1e-51
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 200 4e-51
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 189 5e-48
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 189 5e-48
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 184 2e-46
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 129 7e-30
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 129 7e-30
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 129 7e-30
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 91 3e-18
gi|95089461 discs large homolog 5 [Homo sapiens] 85 2e-16
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 82 2e-15
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 82 2e-15
gi|10092691 tight junction protein 3 [Homo sapiens] 82 2e-15
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 72 1e-12
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 72 1e-12
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 1352 bits (3499), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIR 60
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIR
Sbjct: 1 MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIR 60
Query: 61 QQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVK 120
QQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVK
Sbjct: 61 QQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVK 120
Query: 121 ILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF 180
ILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
Sbjct: 121 ILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF 180
Query: 181 PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDE 240
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDE
Sbjct: 181 PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDE 240
Query: 241 RVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDE 300
RVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDE
Sbjct: 241 RVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDE 300
Query: 301 VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD 360
VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
Sbjct: 301 VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD 360
Query: 361 DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMK 420
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMK
Sbjct: 361 DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMK 420
Query: 421 QTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKR 480
QTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKR
Sbjct: 421 QTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKR 480
Query: 481 PIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADI 540
PIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADI
Sbjct: 481 PIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADI 540
Query: 541 AAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPP 600
AAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPP
Sbjct: 541 AAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPP 600
Query: 601 SQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLIN 660
SQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLIN
Sbjct: 601 SQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLIN 660
Query: 661 KLDTEPQWVPSTWLR 675
KLDTEPQWVPSTWLR
Sbjct: 661 KLDTEPQWVPSTWLR 675
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 396 bits (1018), Expect = e-110
Identities = 226/564 (40%), Positives = 340/564 (60%), Gaps = 52/564 (9%)
Query: 143 SQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNA----QDLAQEVQTVLK 198
SQED++ L + K + KIH + H + P P++ A DLA+E+Q K
Sbjct: 31 SQEDLTFLWDMFGEKSLHSLVKIHEKL--HYYEKQSPVPILHGAAALADDLAEELQN--K 86
Query: 199 PVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQ--LEPITDERVYESIGQYGGETVKI 256
P++ E +EL LL+ P+++ALL HD VA++ L P+ ++ E ++VKI
Sbjct: 87 PLN-SEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEE------DSVKI 139
Query: 257 VRIEKARDIPLGATVRNEMDS--VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDV 314
+R+ K R+ PLGAT++ + + +I++RI++GGAA++SGL+H GDE+ E+NGI + K
Sbjct: 140 IRLVKNRE-PLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRP 198
Query: 315 NEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQ 374
E+ +L+ G +TF +IP + + P+KE + +KA FDY+P++D +PC+E GLSF+
Sbjct: 199 EEIIQILAQSQGAITFKIIPGSK-EETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFK 257
Query: 375 KGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEK--- 431
KGDIL ++SQ+D WWQA E D + P AGL+P K FQ++R A+++ E +P K
Sbjct: 258 KGDILQIMSQDDATWWQAKHEADAN--PRAGLIPSKHFQERRLALRRP-EILVQPLKVSN 314
Query: 432 ---SG--KLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRK-RPIILI 485
SG K + + KK K +Y K+D YD ++ TYEE++ Y + N K R ++L+
Sbjct: 315 RKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLV 374
Query: 486 GPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKF 545
GP G NEL+++L+ + + VPHTTR+RR QE G +Y F+S+ FE D+ KF
Sbjct: 375 GPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKF 434
Query: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
IE+GE++ N YGTSIDSVR V+ K+CLL ++ ++K LR + KPY+IFI PPS ERL
Sbjct: 435 IEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERL 494
Query: 606 RALLAKEGKNPK---------------PEELREIIEKTREMEQNNGHYFDTAIVNSDLDK 650
R + KN K E+ +E+I+ + ME GH FD I+N DL
Sbjct: 495 R----ETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTV 550
Query: 651 AYQELLRLINKLDTEPQWVPSTWL 674
A+ EL +KL+TE WVP +WL
Sbjct: 551 AFNELKTTFDKLETETHWVPVSWL 574
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 357 bits (917), Expect = 2e-98
Identities = 205/577 (35%), Positives = 337/577 (58%), Gaps = 56/577 (9%)
Query: 140 DSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKP 199
DS +E++ L + K KIH + + ++ P P++ +A LA++V L+
Sbjct: 24 DSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQS--PTPVLHSAVALAEDVMEELQA 81
Query: 200 VH-HKEGQELTALLNTPHIQALLLAHDKVAEQEMQ--LEPITDERVYESIGQYGGETVKI 256
H + +EL LL+TPH++A+L+ HD VA++ L P+ D + E + E+VKI
Sbjct: 82 ASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDN-IDEDFDE---ESVKI 137
Query: 257 VRIEKARDIPLGATVRNEMDS--VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDV 314
VR+ K ++ PLGAT+R + S V+++RI++GGAA++SGL+H GDE+ E+NGI + K
Sbjct: 138 VRLVKNKE-PLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRP 196
Query: 315 NEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQ 374
+E+ +L+ G++T +IP+ Q + KE+ + ++A F Y+P +D +PC+E GL FQ
Sbjct: 197 DEISQILAQSQGSITLKIIPATQ-EEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQ 255
Query: 375 KGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMK---------QTIEE 425
+ +L V+SQ+DP WWQA R GD + + AGL+P K FQ++R + + Q++ +
Sbjct: 256 RRQVLEVVSQDDPTWWQAKRVGDTNLR--AGLIPSKGFQERRLSYRRAAGTLPSPQSLRK 313
Query: 426 -------DKEP---------------EKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEI 463
DKE +S +L C ++R + ++ E+
Sbjct: 314 PPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGC-----RERLGGSQEGKMSSGAESPEL 368
Query: 464 LTYEEMSLY-HQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQE 522
LTYEE++ Y HQP R R ++LIG +EL+Q+++ + F AVPHTTR R+ E
Sbjct: 369 LTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHE 428
Query: 523 VAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSL 582
G +YHFVS+QAFEAD+ KF+EHGE+++NLYGTS+++++ V+ K+CL+ + ++L
Sbjct: 429 KEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEAL 488
Query: 583 KTLRNSDLKPYIIFIAPPSQERLR----ALLAKEGKNPKPEELREIIEKTREMEQNNGHY 638
K LR S+ KPYIIF+ P QE+ + + ++ P E+ +E+ ++++ GH
Sbjct: 489 KQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHL 548
Query: 639 FDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR 675
D +V DL AY +L ++ KL + WVP +W+R
Sbjct: 549 VDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR 585
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 348 bits (892), Expect = 1e-95
Identities = 194/541 (35%), Positives = 313/541 (57%), Gaps = 34/541 (6%)
Query: 146 DISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEG 205
D+ L +++N ++ K H + +A + N +L E+ + P+ + +
Sbjct: 21 DLIFLKGIMENPIVKSLAKAHERLEDSKLEA-----VSDNNLELVNEILEDITPLINVDE 75
Query: 206 Q--ELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQY--GGETVKIVRIEK 261
EL +L PH Q+LL AHD VA + P + E SI + ++I+ I K
Sbjct: 76 NVAELVGILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNNSSINNQLLPVDAIRILGIHK 135
Query: 262 ARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLL 321
PLG T R E + ++I+RI+ GG ++ GLLH GD + E+NG E+ G + E+ +LL
Sbjct: 136 RAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELL 194
Query: 322 SDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHV 381
++ G++T ++PS + P + + VK HFDY+P +D +PC+E GL F KG+IL +
Sbjct: 195 KNISGSVTLKILPSYRDTITPQQ---VFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQI 251
Query: 382 ISQEDPNWWQA--YREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAK 439
+++EDPNWWQA +EG AGL+P + +++R+A + ++ P +C
Sbjct: 252 VNREDPNWWQASHVKEGGS-----AGLIPSQFLEEKRKAFVRRDWDNSGP------FCGT 300
Query: 440 KNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRL 499
+ KK+KK++Y +N ++D EI YEE++ P +++ ++LIG Q G+ L+ R
Sbjct: 301 ISSKKKKKMMYLTTRNAEFDRHEIQIYEEVA--KMPPFQRKTLVLIGAQGVGRRSLKNRF 358
Query: 500 MNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTS 559
+ RF + VP T+R R+ E G+ Y FVSR EADI AGK++EHGE+E NLYGT
Sbjct: 359 IVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTK 418
Query: 560 IDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRAL---LAKEGKNP 616
IDS+ +V+ +G+ C+L + Q+LK LR S+ PY++FIA P E LRA+ + G
Sbjct: 419 IDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITT 478
Query: 617 K---PEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTW 673
K +L++ ++++ +++ HYFD I+N +LDKA+++L I KL EPQWVP +W
Sbjct: 479 KLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISW 538
Query: 674 L 674
+
Sbjct: 539 V 539
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 340 bits (873), Expect = 2e-93
Identities = 186/495 (37%), Positives = 291/495 (58%), Gaps = 27/495 (5%)
Query: 193 VQTVLKPVHHKEGQELTA-----LLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIG 247
VQ +L+ + H Q TA +L PH Q+LL HD VA + + P +
Sbjct: 71 VQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSN 130
Query: 248 Q-YGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
Q + V++V I K LG T R E ++I+RI+ GG + GLLH GD + E+NG
Sbjct: 131 QPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNG 190
Query: 307 IEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPC 366
+ G D + +LL + G++ ++PS Q P + + VK HFDYDP+ D +PC
Sbjct: 191 QPV-GSDPRALQELLRNASGSVILKILPSYQEPHLPRQ---VFVKCHFDYDPARDSLIPC 246
Query: 367 RELGLSFQKGDILHVISQEDPNWWQA-YREGDEDNQPLAGLVPGKSFQQQREAMKQTIEE 425
+E GL F GD+L +++Q+D NWWQA + EG AGL+P + +++R+A ++
Sbjct: 247 KEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS-----AGLIPSQLLEEKRKAF---VKR 298
Query: 426 DKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILI 485
D E + C + KK+K+++Y KN ++D E+L YEE++ P R++ ++LI
Sbjct: 299 DLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVA--RMPPFRRKTLVLI 356
Query: 486 GPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKF 545
G Q G+ L+ +L+ + DR+ + VP+T+R +D E G+ Y FVSR EAD+ AG++
Sbjct: 357 GAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRY 416
Query: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
+EHGE+E NLYGT IDS+R V+ +GK+C+L + Q++K LR ++ PY++FI P E L
Sbjct: 417 LEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETL 476
Query: 606 RAL--LAKEG----KNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLI 659
RA+ A E K +LR +E++ +++ GHYFD +VNS+L++ ++EL +
Sbjct: 477 RAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAM 536
Query: 660 NKLDTEPQWVPSTWL 674
KL TEPQWVP +W+
Sbjct: 537 EKLRTEPQWVPVSWV 551
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 308 bits (789), Expect = 1e-83
Identities = 201/603 (33%), Positives = 321/603 (53%), Gaps = 77/603 (12%)
Query: 137 TLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTV 196
+L S+ + LL L+ + Q KI++ + K P +AQ L+ EV +
Sbjct: 40 SLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKL--VPATPHAQVLSYEVVEL 97
Query: 197 LKPVHHK-EGQELTALLNTPHIQALLLAHDKVAEQEMQ-LEPITDERVYESIGQYGGETV 254
L+ E QEL +L PH +ALL AHD +A+++ + L P + + ES E +
Sbjct: 98 LRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPES-----EEAM 152
Query: 255 KIVRIEKARDIPLGATV-RNEMDS-VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGK 312
+IV + K + PLGAT+ R+EM ++++RI+ GG AE+SGLL+ GD+++E+NG+ + G
Sbjct: 153 RIVCLVKNQQ-PLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGL 211
Query: 313 DVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLS 372
D +V +L+ GT+ F ++P PP + +++V+A +Y P +DP +PC + GL
Sbjct: 212 DPEQVIHILAMSRGTIMFKVVPVSD--PPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLP 269
Query: 373 FQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSF--QQQRE-----------AM 419
FQKGDIL ++ Q D WWQA + D AGLVP ++QRE +
Sbjct: 270 FQKGDILQIVDQNDALWWQARKISDPAT--CAGLVPSNHLLKRKQREFWWSQPYQPHTCL 327
Query: 420 KQTIEEDKEPEKSGKL--WCAKKNKKKRKKVLYNANKND--DYDNEEILT---------- 465
K T+ E E K+ C + +++ + + +K + Y + +
Sbjct: 328 KSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCR 387
Query: 466 -------------------------YEEMSLYHQ-PANRKRPIILIGPQNCGQNELRQRL 499
YEE+ Y + P+++ R I+L+GP G NELR++L
Sbjct: 388 RKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQL 447
Query: 500 MNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTS 559
+ F SAVPHTTR+++ E+ GR+YH+VS++ FE I + + +E+GE++ +LYGTS
Sbjct: 448 IEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTS 507
Query: 560 IDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS-----QERLRALLAKE-- 612
+D+V+ V+ GKIC++ L Q ++ +R +LKPY+IFI P + Q R A + +
Sbjct: 508 VDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYY 567
Query: 613 -GKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPS 671
K E+L+E+ + ME G +FD IVN L A +LL I K EPQWVP+
Sbjct: 568 VDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
Query: 672 TWL 674
TW+
Sbjct: 628 TWI 630
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 307 bits (787), Expect = 2e-83
Identities = 171/577 (29%), Positives = 312/577 (54%), Gaps = 47/577 (8%)
Query: 124 IEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKA--SPPFP 181
+ + SL+ I H L D S++D+ L + Q++ +++ I + +PP
Sbjct: 341 VSQVLDSLEEI-HALTDC-SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSD 398
Query: 182 LISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPI---- 237
+ A+++ +E+ + + + +EL +L PH ALL HD VA + E +
Sbjct: 399 AVQRAKEVLEEISCYPE---NNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 455
Query: 238 ----------TDERVYESIGQYGGETVKIVRIEKARDIPLGATVR-NEMDSVIISRIVKG 286
+ E + V++V+ +K D P+G T++ NE++ I++RI+ G
Sbjct: 456 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 515
Query: 287 GAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKET 346
G + G LH GDE+ EINGI + + V ++ +L +M G++TF ++PS + + ++
Sbjct: 516 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDL 575
Query: 347 V---------IHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGD 397
I+V+A F+YDP+ D +PC+E G+ F+ GDI+ +IS++D NWWQ E
Sbjct: 576 PSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENS 635
Query: 398 EDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDD 457
++ AGL+P Q+ R A +E+ K+ +++ W KK K+ + K Y A N
Sbjct: 636 KNGT--AGLIPSPELQEWRVACI-AMEKTKQEQQASCTWFGKKKKQYKDK--YLAKHNAV 690
Query: 458 YDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRS 517
+D +++TYEE+ PA +++ ++L+G G+ ++ L+ K DRFA +PHTTR
Sbjct: 691 FDQLDLVTYEEV--VKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRP 748
Query: 518 RRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
+ E G++Y+FVS DI+ +++E+G E +YGT ++++R++ G I +L +
Sbjct: 749 PKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDV 808
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGH 637
Q+LK LR ++ P+++FIA P+ G N + E L+ + +++ +++ H
Sbjct: 809 EPQALKVLRTAEFAPFVVFIAAPT--------ITPGLN-EDESLQRLQKESDILQRTYAH 859
Query: 638 YFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674
YFD I+N+++D+ + L + + T PQWVP +W+
Sbjct: 860 YFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 896
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 302 bits (773), Expect = 8e-82
Identities = 169/577 (29%), Positives = 309/577 (53%), Gaps = 52/577 (9%)
Query: 124 IEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKA--SPPFP 181
+ + SL+ I H L D S++D+ L + Q++ +++ I + +PP
Sbjct: 347 VSQVLDSLEEI-HALTDC-SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSD 404
Query: 182 LISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPI---- 237
+ A+++ +E+ + + + +EL +L PH ALL HD VA + E +
Sbjct: 405 AVQRAKEVLEEISCYPE---NNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 461
Query: 238 ----------TDERVYESIGQYGGETVKIVRIEKARDIPLGATVR-NEMDSVIISRIVKG 286
+ E + V++V+ +K D P+G T++ NE++ I++RI+ G
Sbjct: 462 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 521
Query: 287 GAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKET 346
G + G LH GDE+ EINGI + + V ++ +L +M G++TF ++PS + + ++
Sbjct: 522 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDL 581
Query: 347 V---------IHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGD 397
I+V+A F+YDP+ D +PC+E G+ F+ GDI+ +IS++D NWWQ E
Sbjct: 582 PSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENS 641
Query: 398 EDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDD 457
++ AGL+P Q+ R A +E+ K+ +++ W KK K+ + K L
Sbjct: 642 KNGT--AGLIPSPELQEWRVACI-AMEKTKQEQQASCTWFGKKKKQYKDKYLAK------ 692
Query: 458 YDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRS 517
N +++TYEE+ PA +++ ++L+G G+ ++ L+ K DRFA +PHTTR
Sbjct: 693 -HNADLVTYEEV--VKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRP 749
Query: 518 RRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
+ E G++Y+FVS DI+ +++E+G E +YGT ++++R++ G I +L +
Sbjct: 750 PKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDV 809
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGH 637
Q+LK LR ++ P+++FIA P+ G N + E L+ + +++ +++ H
Sbjct: 810 EPQALKVLRTAEFAPFVVFIAAPT--------ITPGLN-EDESLQRLQKESDILQRTYAH 860
Query: 638 YFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674
YFD I+N+++D+ + L + + T PQWVP +W+
Sbjct: 861 YFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 897
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 294 bits (752), Expect = 2e-79
Identities = 172/600 (28%), Positives = 310/600 (51%), Gaps = 75/600 (12%)
Query: 124 IEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKA--SPPFP 181
+ + SL+ I H L D S++D+ L + Q++ +++ I + +PP
Sbjct: 347 VSQVLDSLEEI-HALTDC-SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSD 404
Query: 182 LISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPI---- 237
+ A+++ +E+ + + + +EL +L PH ALL HD VA + E +
Sbjct: 405 AVQRAKEVLEEISCYPE---NNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 461
Query: 238 ----------TDERVYESIGQYGGETVKIVRIEKARDIPLGATVR-NEMDSVIISRIVKG 286
+ E + V++V+ +K D P+G T++ NE++ I++RI+ G
Sbjct: 462 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 521
Query: 287 GAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQI-------- 338
G + G LH GDE+ EINGI + + V ++ +L +M G++TF ++PS +
Sbjct: 522 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERD 581
Query: 339 -----KPPPA-------------------KETVIHVKAHFDYDPSDDPYVPCRELGLSFQ 374
+ PA K I+V+A F+YDP+ D +PC+E G+ F+
Sbjct: 582 SPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFR 641
Query: 375 KGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGK 434
GDI+ +IS++D NWWQ E ++ AGL+P Q+ R A +E+ K+ +++
Sbjct: 642 VGDIIQIISKDDHNWWQGKLENSKNG--TAGLIPSPELQEWRVAC-IAMEKTKQEQQASC 698
Query: 435 LWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNE 494
W KK K+ + K L N +++TYEE + PA +++ ++L+G G+
Sbjct: 699 TWFGKKKKQYKDKYLAK-------HNADLVTYEE--VVKLPAFKRKTLVLLGAHGVGRRH 749
Query: 495 LRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKN 554
++ L+ K DRFA +PHTTR + E G++Y+FVS DI+ +++E+G E
Sbjct: 750 IKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDA 809
Query: 555 LYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGK 614
+YGT ++++R++ G I +L + Q+LK LR ++ P+++FIA P+ G
Sbjct: 810 MYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPT--------ITPGL 861
Query: 615 NPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674
N + E L+ + +++ +++ HYFD I+N+++D+ + L + + T PQWVP +W+
Sbjct: 862 N-EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 920
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 273 bits (699), Expect = 3e-73
Identities = 148/488 (30%), Positives = 261/488 (53%), Gaps = 35/488 (7%)
Query: 197 LKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYE------SIGQYG 250
LK + G + L+ +++ LL + L +T++ S Q
Sbjct: 3 LKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVK 62
Query: 251 GETVKIVRI---EKARDIPLGATVR-NEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
G+ V+ VR+ EK + P+G T++ NE S ++RI+ GG + G LH GDE+LEING
Sbjct: 63 GQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEING 122
Query: 307 IEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPC 366
+ V+++ + + G ++ +IP+QQ + P + + ++A FDYDP D +PC
Sbjct: 123 TNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQ---MFMRAQFDYDPKKDNLIPC 179
Query: 367 RELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEED 426
+E GL F GDI+ +I+++D NWWQ EG AGL+P Q+ R A
Sbjct: 180 KEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSPELQEWRVASMAQSAPS 237
Query: 427 KEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIG 486
+ P C+ KKK+ K Y A + +D ++++YEE+ PA +++ ++LIG
Sbjct: 238 EAPS------CSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEV--VRLPAFKRKTLVLIG 289
Query: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFI 546
G++ ++ L+++ ++F VP+TTR R E G++YHF+S + +I+A +F+
Sbjct: 290 ASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFL 349
Query: 547 EHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLR 606
E G ++ N++GT ++V Q+ KI +L + Q+LK +R ++L P+I+FIAP Q
Sbjct: 350 EFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQ---- 405
Query: 607 ALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEP 666
+ E L+++ + + + HYFD ++VN+ +D+ ++L ++ + P
Sbjct: 406 --------GTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSP 457
Query: 667 QWVPSTWL 674
QWVP +W+
Sbjct: 458 QWVPVSWV 465
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 214 bits (544), Expect = 3e-55
Identities = 156/467 (33%), Positives = 231/467 (49%), Gaps = 63/467 (13%)
Query: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
GE K+V + + + + + + +S I+ GG A+ SG L GD++L +NGI++R
Sbjct: 522 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349
G + L T+T +I Q + E IH
Sbjct: 582 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 639
Query: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403
V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E +
Sbjct: 640 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 697
Query: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEE 462
G++P K +++E A +T++ + +P G + KRKK + K Y N+E
Sbjct: 698 MGVIPSKRRVERKERARLKTVKFNAKP---GVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 754
Query: 463 ----------------ILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDR 506
IL+YE ++ Q N RP+I++GP ++ + L+++ D+
Sbjct: 755 QSEQETSDPERGQEDLILSYEPVT--RQEINYTRPVIILGPM---KDRINDDLISEFPDK 809
Query: 507 FASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQ 565
F S VPHTTR +RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR
Sbjct: 810 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 869
Query: 566 VINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREII 625
V GK C+L + ++K L+ + L P IFI P S E L + K E+ ++
Sbjct: 870 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTY 925
Query: 626 EKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
++ ++EQ G YF TAIV D L+ Y + +I + W+PS
Sbjct: 926 DRAIKLEQEFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971
Score = 34.7 bits (78), Expect = 0.30
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323
+S+ +++I+ GGAA+K G L GD +L +N + E +L +
Sbjct: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 372
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 214 bits (544), Expect = 3e-55
Identities = 156/467 (33%), Positives = 231/467 (49%), Gaps = 63/467 (13%)
Query: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
GE K+V + + + + + + +S I+ GG A+ SG L GD++L +NGI++R
Sbjct: 417 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349
G + L T+T +I Q + E IH
Sbjct: 477 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 534
Query: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403
V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E +
Sbjct: 535 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 592
Query: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEE 462
G++P K +++E A +T++ + +P G + KRKK + K Y N+E
Sbjct: 593 MGVIPSKRRVERKERARLKTVKFNAKP---GVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 649
Query: 463 ----------------ILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDR 506
IL+YE ++ Q N RP+I++GP ++ + L+++ D+
Sbjct: 650 QSEQETSDPERGQEDLILSYEPVT--RQEINYTRPVIILGPM---KDRINDDLISEFPDK 704
Query: 507 FASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQ 565
F S VPHTTR +RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR
Sbjct: 705 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 764
Query: 566 VINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREII 625
V GK C+L + ++K L+ + L P IFI P S E L + K E+ ++
Sbjct: 765 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTY 820
Query: 626 EKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
++ ++EQ G YF TAIV D L+ Y + +I + W+PS
Sbjct: 821 DRAIKLEQEFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866
Score = 34.7 bits (78), Expect = 0.30
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323
+S+ +++I+ GGAA+K G L GD +L +N + E +L +
Sbjct: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 267
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 207 bits (526), Expect = 3e-53
Identities = 148/459 (32%), Positives = 227/459 (49%), Gaps = 65/459 (14%)
Query: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
GE K+V + + + + + + +S I+ GG A+ SG L GD++L +NGI++R
Sbjct: 314 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 373
Query: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349
G + L T+T +I Q + E IH
Sbjct: 374 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 431
Query: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403
V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E +
Sbjct: 432 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 489
Query: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEP---EKSGKLWCAKKNKKKRKKVLYNANKNDDYD 459
G++P K +++E A +T++ + +P + G + +D Y
Sbjct: 490 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDI---------------PGLGDDGYG 534
Query: 460 NEEILTYEEMSLYHQPANRK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHT 514
+ + E++ L ++P R+ RP+I++GP ++ + L+++ D+F S VPHT
Sbjct: 535 TKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHT 591
Query: 515 TRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKIC 573
TR +RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR V GK C
Sbjct: 592 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 651
Query: 574 LLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQ 633
+L + ++K L+ + L P IFI P S E L + K E+ ++ ++ ++EQ
Sbjct: 652 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTYDRAIKLEQ 707
Query: 634 NNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
G YF TAIV D L+ Y + +I + W+PS
Sbjct: 708 EFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Score = 34.7 bits (78), Expect = 0.30
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323
+S+ +++I+ GGAA+K G L GD +L +N + E +L +
Sbjct: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 206 bits (524), Expect = 6e-53
Identities = 136/427 (31%), Positives = 221/427 (51%), Gaps = 44/427 (10%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL--- 332
+ + IS I+ GG A+ SG L +GD ++ +N +++R + L + +T V
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546
Query: 333 ----------------------IPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELG 370
I S +++ ++V+A FDYD + D +P + G
Sbjct: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--G 604
Query: 371 LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQRE-AMKQTIEEDKEP 429
L+F+ GDILHVI+ D WWQA + + G++P K +++E A +T++ + +
Sbjct: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
Query: 430 EKSGKLWCAKKNKKKRKKVLYNANKNDDY---DNEEILTYEEMSLYHQPANRKRPIILIG 486
G++ K K V NA+ ++ E +L+YE ++ Q N RP+I++G
Sbjct: 665 RDKGEI-PDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVN--QQEVNYTRPVIILG 721
Query: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKF 545
P ++ + L+++ D+F S VPHTTR +RD EV GRDYHFV SR+ E DI KF
Sbjct: 722 PM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 778
Query: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
IE G++ +LYGTS+ SVR+V GK C+L + ++K L+ + L P IFI P S E +
Sbjct: 779 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 838
Query: 606 RALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDT 664
+ K E+ R+ E+ ++EQ +F TAIV D L+ Y ++ ++I +
Sbjct: 839 MEM----NKRLTEEQARKTFERAMKLEQEFTEHF-TAIVQGDTLEDIYNQVKQIIEEQSG 893
Query: 665 EPQWVPS 671
WVP+
Sbjct: 894 SYIWVPA 900
Score = 37.0 bits (84), Expect = 0.060
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNV 377
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 201 bits (512), Expect = 1e-51
Identities = 139/451 (30%), Positives = 223/451 (49%), Gaps = 70/451 (15%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL--- 332
+ + IS I+ GG A+ SG L +GD ++ +N +++R + L + +T V
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546
Query: 333 ----------------------IPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELG 370
I S +++ ++V+A FDYD + D +P + G
Sbjct: 547 PEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--G 604
Query: 371 LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQRE-AMKQTIEEDKEP 429
L+F+ GDILHVI+ D WWQA + + G++P K +++E A +T++ + +
Sbjct: 605 LNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKT 664
Query: 430 EKSGKLWCAKKNKK--KRKKVLYNANKNDDYDNEE------------------------- 462
G+ + K+ K RK Y KN D +E
Sbjct: 665 RDKGQSFNDKRKKNLFSRKFPFY---KNKDQSEQETSDADQHVTSNASDSESSYRGQEEY 721
Query: 463 ILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQE 522
+L+YE ++ Q N RP+I++GP ++ + L+++ D+F S VPHTTR +RD E
Sbjct: 722 VLSYEPVN--QQEVNYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYE 776
Query: 523 VAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQS 581
V GRDYHFV SR+ E DI KFIE G++ +LYGTS+ SVR+V GK C+L + +
Sbjct: 777 VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNA 836
Query: 582 LKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDT 641
+K L+ + L P IFI P S E + + K E+ R+ E+ ++EQ +F T
Sbjct: 837 IKRLQIAQLYPISIFIKPKSMENIMEM----NKRLTEEQARKTFERAMKLEQEFTEHF-T 891
Query: 642 AIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
AIV D L+ Y ++ ++I + WVP+
Sbjct: 892 AIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 922
Score = 37.0 bits (84), Expect = 0.060
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNV 377
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 201 bits (512), Expect = 1e-51
Identities = 138/454 (30%), Positives = 214/454 (47%), Gaps = 73/454 (16%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
+ + +S I+ GG A+ SG L GD +L +NG+ +R + L ++T V
Sbjct: 70 EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVA--- 126
Query: 336 QQIKPPP-----------------------------AKETVIHVKAHFDYDPSDDPYVPC 366
Q +P +++ ++V+A FDYD + D +P
Sbjct: 127 -QYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 185
Query: 367 RELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEED 426
+ GLSF GDILHVI+ D WWQA G++P K +++E + ++
Sbjct: 186 Q--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERAR--LKTV 241
Query: 427 KEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYE------------------- 467
K ++G + + K KRKK + K Y ++E + E
Sbjct: 242 KFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSS 301
Query: 468 ----EMSLYHQPANRK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSR 518
+ L ++P R+ RP+I++GP ++ + L+++ +F S VPHTTR R
Sbjct: 302 KGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPR 358
Query: 519 RDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
RD EV G+DYHFV SR+ E DI KFIE G+F NLYGTSI SVR V GK C+L +
Sbjct: 359 RDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDV 418
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGH 637
++K L+ + L P IFI P S E L + + E+ +I +K ++EQ G
Sbjct: 419 SGNAIKRLQQAQLYPIAIFIKPKSIEALMEM----NRRQTYEQANKIYDKAMKLEQEFGE 474
Query: 638 YFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPS 671
YF + L++ Y ++ ++I WVPS
Sbjct: 475 YFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 508
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 200 bits (508), Expect = 4e-51
Identities = 135/426 (31%), Positives = 210/426 (49%), Gaps = 49/426 (11%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
+ + +S I+ GG A+ SG L GD +L +NG+ +R + L ++T V
Sbjct: 407 EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVA--- 463
Query: 336 QQIKPPP-----------------------------AKETVIHVKAHFDYDPSDDPYVPC 366
Q +P +++ ++V+A FDYD + D +P
Sbjct: 464 -QYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 522
Query: 367 RELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEED 426
+ GLSF GDILHVI+ D WWQA G++P K +++E + ++
Sbjct: 523 Q--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERAR--LKTV 578
Query: 427 KEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIG 486
K ++G + + ++ Y A KN + IL+YE ++ Q + RP+I++G
Sbjct: 579 KFHARTGMIE-SNRDFPGLSDDYYGA-KNLKGQEDAILSYEPVT--RQEIHYARPVIILG 634
Query: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKF 545
P ++ + L+++ +F S VPHTTR RRD EV G+DYHFV SR+ E DI KF
Sbjct: 635 PM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKF 691
Query: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
IE G+F NLYGTSI SVR V GK C+L + ++K L+ + L P IFI P S E L
Sbjct: 692 IEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEAL 751
Query: 606 RALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTE 665
+ + E+ +I +K ++EQ G YF + L++ Y ++ ++I
Sbjct: 752 MEM----NRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGH 807
Query: 666 PQWVPS 671
WVPS
Sbjct: 808 YIWVPS 813
Score = 35.8 bits (81), Expect = 0.13
Identities = 14/35 (40%), Positives = 25/35 (71%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
+S+ I++I++GGAA+K G L GD +L +N ++
Sbjct: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 189 bits (481), Expect = 5e-48
Identities = 130/428 (30%), Positives = 201/428 (46%), Gaps = 73/428 (17%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
+ + IS I+ GG A+ SG L +GD++L +NG+++R + L + T+T +
Sbjct: 377 EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA--- 433
Query: 336 QQIKPPPAK--ETVIH---------------------------VKAHFDYDPSDDPYVPC 366
Q KP E IH ++A FDYD + D C
Sbjct: 434 -QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----C 488
Query: 367 RELG--LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIE 424
L LSF+ GD+LHVI D WWQA R + G +P K ++RE
Sbjct: 489 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERRE------- 541
Query: 425 EDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIIL 484
W K K + ++ + +L+YE ++ + RPII+
Sbjct: 542 -----------WSRLKAKD------WGSSSGSQGREDSVLSYETVT--QMEVHYARPIII 582
Query: 485 IGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS-RQAFEADIAAG 543
+GP N+ L+++ D+F S VPHTTR +R+ E+ GRDYHFVS R+ E DI A
Sbjct: 583 LGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAH 639
Query: 544 KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQE 603
KFIE G++ +LYGTS+ SVR+V GK C+L + +++ L+ + L P IFI P S E
Sbjct: 640 KFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLE 699
Query: 604 RLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLD 663
+ + K E+ R+ ++ ++EQ F + ++ Y ++ R+I L
Sbjct: 700 NVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLS 755
Query: 664 TEPQWVPS 671
WVP+
Sbjct: 756 GPYIWVPA 763
Score = 37.7 bits (86), Expect = 0.035
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 204 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 189 bits (481), Expect = 5e-48
Identities = 130/428 (30%), Positives = 201/428 (46%), Gaps = 73/428 (17%)
Query: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
+ + IS I+ GG A+ SG L +GD++L +NG+++R + L + T+T +
Sbjct: 331 EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA--- 387
Query: 336 QQIKPPPAK--ETVIH---------------------------VKAHFDYDPSDDPYVPC 366
Q KP E IH ++A FDYD + D C
Sbjct: 388 -QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----C 442
Query: 367 RELG--LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIE 424
L LSF+ GD+LHVI D WWQA R + G +P K ++RE
Sbjct: 443 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERRE------- 495
Query: 425 EDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIIL 484
W K K + ++ + +L+YE ++ + RPII+
Sbjct: 496 -----------WSRLKAKD------WGSSSGSQGREDSVLSYETVT--QMEVHYARPIII 536
Query: 485 IGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS-RQAFEADIAAG 543
+GP N+ L+++ D+F S VPHTTR +R+ E+ GRDYHFVS R+ E DI A
Sbjct: 537 LGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAH 593
Query: 544 KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQE 603
KFIE G++ +LYGTS+ SVR+V GK C+L + +++ L+ + L P IFI P S E
Sbjct: 594 KFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLE 653
Query: 604 RLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLD 663
+ + K E+ R+ ++ ++EQ F + ++ Y ++ R+I L
Sbjct: 654 NVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLS 709
Query: 664 TEPQWVPS 671
WVP+
Sbjct: 710 GPYIWVPA 717
Score = 37.7 bits (86), Expect = 0.035
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 184 bits (467), Expect = 2e-46
Identities = 120/335 (35%), Positives = 182/335 (54%), Gaps = 36/335 (10%)
Query: 348 IHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLV 407
++V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E + G++
Sbjct: 21 LYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVI 78
Query: 408 PGKSFQQQRE-AMKQTIEEDKEP---EKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEI 463
P K +++E A +T++ + +P + G + +D Y + +
Sbjct: 79 PSKRRVERKERARLKTVKFNAKPGVIDSKGDI---------------PGLGDDGYGTKTL 123
Query: 464 LTYEEMSLYHQPANRK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSR 518
E++ L ++P R+ RP+I++GP ++ + L+++ D+F S VPHTTR +
Sbjct: 124 RGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPK 180
Query: 519 RDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR V GK C+L +
Sbjct: 181 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 240
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGH 637
++K L+ + L P IFI P S E L + K E+ ++ ++ ++EQ G
Sbjct: 241 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTYDRAIKLEQEFGE 296
Query: 638 YFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
YF TAIV D L+ Y + +I + W+PS
Sbjct: 297 YF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 330
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 129 bits (325), Expect = 7e-30
Identities = 67/183 (36%), Positives = 105/183 (57%), Gaps = 1/183 (0%)
Query: 480 RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEAD 539
RP++L GP G++ L +RL+ + F +V HTTR+ R E G+DY+FV+R+ + D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 540 IAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAP 599
IAAG FIEH EF NLYGTS +V+ V +IC+L + Q ++ ++ +DL+P I + P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 600 PSQERLRALLAKEGKNPKPEELREIIEKTREMEQN-NGHYFDTAIVNSDLDKAYQELLRL 658
PS L L + + ++ + +ME + FD I+N LD+AY EL
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
Query: 659 INK 661
+++
Sbjct: 185 LSE 187
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 129 bits (325), Expect = 7e-30
Identities = 67/183 (36%), Positives = 105/183 (57%), Gaps = 1/183 (0%)
Query: 480 RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEAD 539
RP++L GP G++ L +RL+ + F +V HTTR+ R E G+DY+FV+R+ + D
Sbjct: 26 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 85
Query: 540 IAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAP 599
IAAG FIEH EF NLYGTS +V+ V +IC+L + Q ++ ++ +DL+P I + P
Sbjct: 86 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 145
Query: 600 PSQERLRALLAKEGKNPKPEELREIIEKTREMEQN-NGHYFDTAIVNSDLDKAYQELLRL 658
PS L L + + ++ + +ME + FD I+N LD+AY EL
Sbjct: 146 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 205
Query: 659 INK 661
+++
Sbjct: 206 LSE 208
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 129 bits (325), Expect = 7e-30
Identities = 67/183 (36%), Positives = 105/183 (57%), Gaps = 1/183 (0%)
Query: 480 RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEAD 539
RP++L GP G++ L +RL+ + F +V HTTR+ R E G+DY+FV+R+ + D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 540 IAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAP 599
IAAG FIEH EF NLYGTS +V+ V +IC+L + Q ++ ++ +DL+P I + P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 600 PSQERLRALLAKEGKNPKPEELREIIEKTREMEQN-NGHYFDTAIVNSDLDKAYQELLRL 658
PS L L + + ++ + +ME + FD I+N LD+AY EL
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
Query: 659 INK 661
+++
Sbjct: 185 LSE 187
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 90.9 bits (224), Expect = 3e-18
Identities = 55/182 (30%), Positives = 91/182 (50%), Gaps = 2/182 (1%)
Query: 482 IILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIA 541
+IL GP+ CG+ EL RL + F HTTR E DYHF+S+ F+ +
Sbjct: 417 LILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVN 476
Query: 542 AGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS 601
GKFI + + YG + D+V + G + + + +++L+ S +P I + P +
Sbjct: 477 MGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMN 536
Query: 602 QERLRALLAKEGKNPKPEELREI--IEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLI 659
+E+ L ++G + E + ++ ++ QN YFD I DLD AYQ+L +LI
Sbjct: 537 KEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLI 596
Query: 660 NK 661
+
Sbjct: 597 RE 598
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 85.1 bits (209), Expect = 2e-16
Identities = 92/446 (20%), Positives = 191/446 (42%), Gaps = 59/446 (13%)
Query: 255 KIVRIEKARDIPLGATV-RNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKD 313
++V I+K++ + LG + + V ++ + A+ L GD +LE +++R K
Sbjct: 1501 RVVFIKKSQ-LELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKT 1559
Query: 314 VNEVF-DLLSDMHGT-LTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGL 371
V EV+ ++L G L P + K +++A +D + E L
Sbjct: 1560 VEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDR-------LADVEQEL 1612
Query: 372 SFQKGDILHV---ISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKE 428
SF+K DIL+V + Q W A++ + + G +P K Q + + ++ E K+
Sbjct: 1613 SFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKD 1672
Query: 429 PEKSGKLWCAK------KNKKKRKKVLYNANKN----DDYDNEEILTYEE-MSLYHQPAN 477
+ K A + K K K+ K+ D + ++ I +E+ +SL +Q
Sbjct: 1673 DNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQ 1732
Query: 478 RK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS 532
+ RP++++GP + +++ L+N+ +F ++ S
Sbjct: 1733 KVDCTALRPVLILGPL---LDVVKEMLVNEAPGKFCRCPLEVMKA--------------S 1775
Query: 533 RQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKP 592
+QA E + F+++ + T++ S++++ + CLL + +++ L + + P
Sbjct: 1776 QQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYP 1835
Query: 593 YIIFIAPPSQERLRALLAKEGKNP-------KPEELREIIEKTREMEQNNGHYFDTAIVN 645
+IFI S + + KE ++P +E E +++EQ YF I
Sbjct: 1836 IVIFIHYKSAKHI-----KEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQG 1890
Query: 646 SDLDKAYQELLRLINKLDTEPQWVPS 671
L ++L ++N+ + W+P+
Sbjct: 1891 GALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 250 GGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEI 309
GG+ V + I + G ++ N V + ++ G A K G L GD ++ INGI +
Sbjct: 713 GGKVVTPLHINLSGQKDSGISLEN---GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIAL 769
Query: 310 RGKDVNEVFDLLSDMHGTLTFVLI 333
K +NE LL +LT L+
Sbjct: 770 DNKSLNECESLLRSCQDSLTLSLL 793
Score = 38.5 bits (88), Expect = 0.020
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 252 ETVKIVRIEKARDIPLGAT-VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
E + V+++K + PLG + V E + +S++ G A ++GL + GD++LE NGI +R
Sbjct: 1346 EEPRHVKVQKGSE-PLGISIVSGEKGGIYVSKVTVGSIAHQAGLEY-GDQLLEFNGINLR 1403
Query: 311 GKDVNEVFDLLSDMHGTLTFV 331
+ ++ T+T +
Sbjct: 1404 SATEQQARLIIGQQCDTITIL 1424
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 82.0 bits (201), Expect = 2e-15
Identities = 105/516 (20%), Positives = 211/516 (40%), Gaps = 81/516 (15%)
Query: 182 LISNAQDLAQEVQTVLKPVHH------KEGQELTALLN---TPHIQALLLAHDKVAEQEM 232
L S ++ + V PV H K +E+T N TP + + +V + ++
Sbjct: 338 LRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDV 397
Query: 233 QLEPITDERVYESIGQYGG---ETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAA 289
L + V + G ++K+V+ K + L N++ + ++ +++ A
Sbjct: 398 DLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDV-GIFVAGVLEDSPA 456
Query: 290 EKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDM-HGTLTFVLIPSQQIKPPPAKETVI 348
K GL EGD++L +N ++ E L D+ G +L ++ E+ +
Sbjct: 457 AKEGL-EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
Query: 349 ----HVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS---QEDPNWWQAYREGDEDNQ 401
+++ HF+Y+ + PY GLSF KG++ V+ W A R G +
Sbjct: 516 GDSFYIRTHFEYE-KESPY------GLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKE 568
Query: 402 PLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNE 461
G++P K+ +Q +++ T+ + +++ W + + ++ + +D +
Sbjct: 569 VERGIIPNKNRAEQLASVQYTLPKTAGGDRA-DFWRFRGLRSSKRNL---RKSREDLSAQ 624
Query: 462 EILT----YEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRS 517
+ T YE + L + A RP+ + GP + R++L +E D + A +
Sbjct: 625 PVQTKFPAYERVVL--REAGFLRPVTIFGPI---ADVAREKLAREEPDIYQIAKSEPRDA 679
Query: 518 RRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
DQ +G + +++Q+I+ K LL +
Sbjct: 680 GTDQRSSGI-------------------------------IRLHTIKQIIDQDKHALLDV 708
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQE---RLRALLAKEGKNPKPEELREIIEKTREMEQN 634
++ L + P ++F+ P S++ +R L E + + R++ E++ ++ +N
Sbjct: 709 TPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESR----KSARKLYERSHKLRKN 764
Query: 635 NGHYFDTAI-VNSDLDKAYQELLRLINKLDTEPQWV 669
N H F T I +NS D Y L I + + WV
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 36.6 bits (83), Expect = 0.078
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 5/108 (4%)
Query: 225 DKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIV 284
D+ A +E L P +D R S V +V+ K + L + + I
Sbjct: 158 DRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA-----SHIFVKEIS 212
Query: 285 KGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL 332
+ A + G + EGD VL+ING + + L+ G L V+
Sbjct: 213 QDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVV 260
Score = 32.0 bits (71), Expect = 1.9
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Query: 277 SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEI 309
S++IS ++KGG AE G L E D V +NG+ +
Sbjct: 53 SIVISDVLKGGPAE--GQLQENDRVAMVNGVSM 83
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 82.0 bits (201), Expect = 2e-15
Identities = 105/516 (20%), Positives = 211/516 (40%), Gaps = 81/516 (15%)
Query: 182 LISNAQDLAQEVQTVLKPVHH------KEGQELTALLN---TPHIQALLLAHDKVAEQEM 232
L S ++ + V PV H K +E+T N TP + + +V + ++
Sbjct: 338 LRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDV 397
Query: 233 QLEPITDERVYESIGQYGG---ETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAA 289
L + V + G ++K+V+ K + L N++ + ++ +++ A
Sbjct: 398 DLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDV-GIFVAGVLEDSPA 456
Query: 290 EKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDM-HGTLTFVLIPSQQIKPPPAKETVI 348
K GL EGD++L +N ++ E L D+ G +L ++ E+ +
Sbjct: 457 AKEGL-EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDV 515
Query: 349 ----HVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS---QEDPNWWQAYREGDEDNQ 401
+++ HF+Y+ + PY GLSF KG++ V+ W A R G +
Sbjct: 516 GDSFYIRTHFEYE-KESPY------GLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKE 568
Query: 402 PLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNE 461
G++P K+ +Q +++ T+ + +++ W + + ++ + +D +
Sbjct: 569 VERGIIPNKNRAEQLASVQYTLPKTAGGDRA-DFWRFRGLRSSKRNL---RKSREDLSAQ 624
Query: 462 EILT----YEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRS 517
+ T YE + L + A RP+ + GP + R++L +E D + A +
Sbjct: 625 PVQTKFPAYERVVL--REAGFLRPVTIFGPI---ADVAREKLAREEPDIYQIAKSEPRDA 679
Query: 518 RRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSL 577
DQ +G + +++Q+I+ K LL +
Sbjct: 680 GTDQRSSGI-------------------------------IRLHTIKQIIDQDKHALLDV 708
Query: 578 RTQSLKTLRNSDLKPYIIFIAPPSQE---RLRALLAKEGKNPKPEELREIIEKTREMEQN 634
++ L + P ++F+ P S++ +R L E + + R++ E++ ++ +N
Sbjct: 709 TPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESR----KSARKLYERSHKLRKN 764
Query: 635 NGHYFDTAI-VNSDLDKAYQELLRLINKLDTEPQWV 669
N H F T I +NS D Y L I + + WV
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 36.6 bits (83), Expect = 0.078
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 5/108 (4%)
Query: 225 DKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIV 284
D+ A +E L P +D R S V +V+ K + L + + I
Sbjct: 158 DRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA-----SHIFVKEIS 212
Query: 285 KGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVL 332
+ A + G + EGD VL+ING + + L+ G L V+
Sbjct: 213 QDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVV 260
Score = 32.0 bits (71), Expect = 1.9
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Query: 277 SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEI 309
S++IS ++KGG AE G L E D V +NG+ +
Sbjct: 53 SIVISDVLKGGPAE--GQLQENDRVAMVNGVSM 83
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 81.6 bits (200), Expect = 2e-15
Identities = 112/551 (20%), Positives = 212/551 (38%), Gaps = 105/551 (19%)
Query: 165 IHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPV-----HHKEGQELTALLNTPHIQA 219
+ +T+ +SPP + A +L+Q + + P E + + + +P ++
Sbjct: 310 LEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRR 369
Query: 220 LLLAHDK-VAEQEMQLEPITDERVYESIGQYGGETV---------KIVRIEKARDIPLGA 269
+ ++E + Q + E Y+ +++ ++VR K + I L
Sbjct: 370 ESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRL 429
Query: 270 TVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLT 329
N++ + +S + G A+ G+ EGD++L++N + + E L +
Sbjct: 430 AGGNDV-GIFVSGVQAGSPADGQGI-QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEE 487
Query: 330 FVLIPS--QQIKPPPAKETV---IHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQ 384
L+ Q I + V +++ HF+ +PS GL F +GD+ HV+
Sbjct: 488 MELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPS-------GLGFTRGDVFHVLDT 540
Query: 385 EDP---------NWWQAYREGDEDNQPLAGLVPGKSFQQQ---REAMKQTI----EEDKE 428
P W A R G + + G++P +S +Q EA ++ +
Sbjct: 541 LHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAG 600
Query: 429 PEKSGKLW-------CAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRP 481
+ W AKK ++ ++ L + Y E + E S KRP
Sbjct: 601 SNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASF-------KRP 653
Query: 482 IILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIA 541
++++GP + Q+L + D+F A T SR D +
Sbjct: 654 VVILGPV---ADIAMQKLTAEMPDQFEIA---ETVSRTD--------------------S 687
Query: 542 AGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS 601
K I+ +D+VR + K LL + +++ L P ++F P S
Sbjct: 688 PSKIIK------------LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPES 735
Query: 602 QERLRAL---LAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAI-VNSDLDKAYQELLR 657
+ L+AL LA + R + + +++ +++ H F I +N D YQEL
Sbjct: 736 RPALKALRQWLAPASR----RSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKA 791
Query: 658 LINKLDTEPQW 668
+I + T P W
Sbjct: 792 IIREQQTRPIW 802
Score = 36.2 bits (82), Expect = 0.10
Identities = 28/128 (21%), Positives = 56/128 (43%), Gaps = 23/128 (17%)
Query: 219 ALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSV 278
AL+ ++ Q++Q++P VK V +++ G + ++ +
Sbjct: 194 ALVSGFKRLPRQDVQMKP-----------------VKSVLVKRRDSEEFGVKLGSQ---I 233
Query: 279 IISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQ-- 336
I I G A + L EGD +L+ING+ + +N+ L+ G L+ +++ +
Sbjct: 234 FIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQ 293
Query: 337 -QIKPPPA 343
+ PPA
Sbjct: 294 FLVNIPPA 301
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/447 (22%), Positives = 189/447 (42%), Gaps = 79/447 (17%)
Query: 239 DERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEG 298
DE +Y G K+VR +K + L N++ + ++ I +G +AE+ GL EG
Sbjct: 502 DEAIY-------GPNTKMVRFKKGDSVGLRLAGGNDV-GIFVAGIQEGTSAEQEGL-QEG 552
Query: 299 DEVLEINGIEIRG-KDVNEVFDLLSDMHGTLTFVLIPSQ----QIKPPPAKETVIHVKAH 353
D++L++N + RG + V LL G + +L S+ + + +++H
Sbjct: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSH 612
Query: 354 FDYDPSDDPYVPCRELGLSFQKGDILHVIS---QEDPNWWQAYREGDEDNQPLAGLVPGK 410
F+ + L+F +G++ V+ W A R G+E + GL+P K
Sbjct: 613 FECEKETPQ-------SLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK---GLIPNK 662
Query: 411 SFQQQREAMKQTIEEDKEPEKS------GKLWCAKKNKKKRKKVLYNANKNDDYDNEEIL 464
S +Q A Q + D +++ G+ KKN +K ++ L + +
Sbjct: 663 SRAEQM-ASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVS----VSTKFP 717
Query: 465 TYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVA 524
YE + L + A KRP++L GP + ++L N+ D F +A + + + A
Sbjct: 718 AYERVLL--REAGFKRPVVLFGPI---ADIAMEKLANELPDWFQTA-------KTEPKDA 765
Query: 525 GRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKT 584
G EK+ +++VRQ+I K LL + +++
Sbjct: 766 GS-------------------------EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDL 800
Query: 585 LRNSDLKPYIIFIAPPSQERLRALLAKEGKNP-KPEELREIIEKTREMEQNNGHYFDTAI 643
L + P +IF P S++ ++ + ++ NP + R++ ++ ++++ H F I
Sbjct: 801 LNYTQWFPIVIFFNPDSRQGVKTM--RQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATI 858
Query: 644 -VNSDLDKAYQELLRLINKLDTEPQWV 669
+NS D + L I E WV
Sbjct: 859 NLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 39.7 bits (91), Expect = 0.009
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 278 VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQ 337
+ + + + G A K G LHEGD +L+ING + + L+ G L V++ Q
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
Query: 338 IKPPPAKETVIHVKAHFDYD 357
+T+I++ + D D
Sbjct: 387 -------QTLINIPSLNDSD 399
Score = 30.8 bits (68), Expect = 4.3
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 257 VRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
+ + RD P N S++IS ++ GG A+ GLL E D V+ +NG
Sbjct: 46 IAVSGGRDNP---HFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNG 90
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/447 (22%), Positives = 189/447 (42%), Gaps = 79/447 (17%)
Query: 239 DERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEG 298
DE +Y G K+VR +K + L N++ + ++ I +G +AE+ GL EG
Sbjct: 502 DEAIY-------GPNTKMVRFKKGDSVGLRLAGGNDV-GIFVAGIQEGTSAEQEGL-QEG 552
Query: 299 DEVLEINGIEIRG-KDVNEVFDLLSDMHGTLTFVLIPSQ----QIKPPPAKETVIHVKAH 353
D++L++N + RG + V LL G + +L S+ + + +++H
Sbjct: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSH 612
Query: 354 FDYDPSDDPYVPCRELGLSFQKGDILHVIS---QEDPNWWQAYREGDEDNQPLAGLVPGK 410
F+ + L+F +G++ V+ W A R G+E + GL+P K
Sbjct: 613 FECEKETPQ-------SLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK---GLIPNK 662
Query: 411 SFQQQREAMKQTIEEDKEPEKS------GKLWCAKKNKKKRKKVLYNANKNDDYDNEEIL 464
S +Q A Q + D +++ G+ KKN +K ++ L + +
Sbjct: 663 SRAEQM-ASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVS----VSTKFP 717
Query: 465 TYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVA 524
YE + L + A KRP++L GP + ++L N+ D F +A + + + A
Sbjct: 718 AYERVLL--REAGFKRPVVLFGPI---ADIAMEKLANELPDWFQTA-------KTEPKDA 765
Query: 525 GRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKT 584
G EK+ +++VRQ+I K LL + +++
Sbjct: 766 GS-------------------------EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDL 800
Query: 585 LRNSDLKPYIIFIAPPSQERLRALLAKEGKNP-KPEELREIIEKTREMEQNNGHYFDTAI 643
L + P +IF P S++ ++ + ++ NP + R++ ++ ++++ H F I
Sbjct: 801 LNYTQWFPIVIFFNPDSRQGVKTM--RQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATI 858
Query: 644 -VNSDLDKAYQELLRLINKLDTEPQWV 669
+NS D + L I E WV
Sbjct: 859 NLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 39.7 bits (91), Expect = 0.009
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 278 VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQ 337
+ + + + G A K G LHEGD +L+ING + + L+ G L V++ Q
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQ 386
Query: 338 IKPPPAKETVIHVKAHFDYD 357
+T+I++ + D D
Sbjct: 387 -------QTLINIPSLNDSD 399
Score = 30.8 bits (68), Expect = 4.3
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 257 VRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
+ + RD P N S++IS ++ GG A+ GLL E D V+ +NG
Sbjct: 46 IAVSGGRDNP---HFENGETSIVISDVLPGGPAD--GLLQENDRVVMVNG 90
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,226,197
Number of Sequences: 37866
Number of extensions: 1217606
Number of successful extensions: 5818
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 209
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 4811
Number of HSP's gapped (non-prelim): 1006
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.