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Search of human proteins with 34761064
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
sapiens]
(887 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 1787 0.0
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 189 1e-47
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 180 5e-45
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 176 9e-44
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 173 7e-43
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 171 3e-42
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 164 3e-40
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 160 6e-39
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 119 2e-26
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 116 8e-26
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 116 8e-26
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 81 5e-15
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 72 2e-12
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 72 2e-12
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 72 2e-12
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 72 3e-12
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 68 3e-11
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 68 3e-11
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 62 2e-09
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 62 2e-09
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 53 1e-06
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 50 9e-06
gi|5454140 tumor susceptibility gene 101 [Homo sapiens] 36 0.14
gi|34577114 cytomatrix protein p110 [Homo sapiens] 34 0.69
gi|118442841 hypothetical protein LOC123591 [Homo sapiens] 32 2.6
gi|116268113 transmembrane protein 99 [Homo sapiens] 32 2.6
gi|27501450 axin 1 isoform a [Homo sapiens] 31 4.5
gi|31083144 axin 1 isoform b [Homo sapiens] 31 4.5
gi|89886480 zinedin isoform 2 [Homo sapiens] 31 4.5
gi|89886477 zinedin isoform 1 [Homo sapiens] 31 4.5
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
sapiens]
Length = 887
Score = 1787 bits (4629), Expect = 0.0
Identities = 887/887 (100%), Positives = 887/887 (100%)
Query: 1 MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT 60
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
Sbjct: 1 MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT 60
Query: 61 CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV 120
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
Sbjct: 61 CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV 120
Query: 121 PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK 180
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
Sbjct: 121 PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK 180
Query: 181 AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG 240
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
Sbjct: 181 AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG 240
Query: 241 DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV 300
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
Sbjct: 241 DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV 300
Query: 301 SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV 360
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
Sbjct: 301 SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV 360
Query: 361 EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK 420
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
Sbjct: 361 EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK 420
Query: 421 DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI 480
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
Sbjct: 421 DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI 480
Query: 481 SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS 540
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
Sbjct: 481 SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS 540
Query: 541 LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK 600
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
Sbjct: 541 LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK 600
Query: 601 IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK 660
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
Sbjct: 601 IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK 660
Query: 661 ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE 720
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
Sbjct: 661 ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE 720
Query: 721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN 780
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
Sbjct: 721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN 780
Query: 781 KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK 840
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
Sbjct: 781 KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK 840
Query: 841 KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
Sbjct: 841 KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 189 bits (480), Expect = 1e-47
Identities = 162/594 (27%), Positives = 262/594 (44%), Gaps = 94/594 (15%)
Query: 293 RDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELL 352
R QL I++ P LT E+++L+W FRY KA K V W + + +LL
Sbjct: 552 RKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLL 611
Query: 353 GKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIK 412
+ + D + A D L M LL NF D
Sbjct: 612 ARREVWD-------------------------QSALDVGLTMQLLDC-------NFSD-- 637
Query: 413 NGLEPTKKDSQSSVSENVSNSGINSAE-IDSSQIITSPLPSVSSPPPASKTKEVPDGENL 471
ENV + E ++ ++ L V A K + D
Sbjct: 638 ---------------ENVRAIAVQKLESLEDDDVLHYLLQLVQ----AVKFEPYHDSA-- 676
Query: 472 EQDLCTFLISRACKNSTLANYLYWYVIVE-CEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
L FL+ R +N + ++L+W++ E + + QQR E YL R A+L
Sbjct: 677 ---LARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYL---RGCGTAMLH 730
Query: 531 G-DKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVE 589
+ V+V+ L + K+K E LQ N E
Sbjct: 731 DFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQ---------NSQLPE 781
Query: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED-----GGKYPVIFKHGDDLRQD 644
+P +P +K + E + S P L FK D +IFKHGDDLRQD
Sbjct: 782 SFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD 841
Query: 645 QLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQ-SVPVAEV----LDTEGS 699
LILQI+ +M+ + E+LDL L PY ++T K G ++ ++ + +A++ + G+
Sbjct: 842 MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGA 901
Query: 700 IQNFFRKYAPSENGPNGISAEV-MDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLF 758
++ + E P + ++ +V SCAGYCV T++LG+GDRH DN+++T+TG LF
Sbjct: 902 FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLF 961
Query: 759 HIDFGYILGR-------DPKPLPPPMKLNKEMVEGMGGTQ-SEQYQEFRKQCYTAFLHLR 810
HIDFG+ILG + + +P + + V G G + S +Q+F+ C A+L LR
Sbjct: 962 HIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALR 1021
Query: 811 RYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLID 864
++NL++ LFS+M+ +P + + D ++ ++D + ++E+A Y I+
Sbjct: 1022 HHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTVGKNEEDAKKYFLDQIE 1073
Score = 35.8 bits (81), Expect = 0.18
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 67 GKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIW 111
G+ + RTS K F+ WN WL+ +K DLP+ A + L I+
Sbjct: 390 GQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIY 434
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 180 bits (457), Expect = 5e-45
Identities = 121/421 (28%), Positives = 213/421 (50%), Gaps = 46/421 (10%)
Query: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
L+ +L FL+ RA N + ++L+W++ E R E Y + L+K
Sbjct: 625 LDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMK 684
Query: 531 GDKSVRVMRSL-----LAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNL 585
+++ +++L L++Q+T + LM R+ L
Sbjct: 685 QGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAY-------------------L 725
Query: 586 SDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED---GGKYPVIFKHGDDLR 642
+ + PL+P + + E T S + P + + E+ GG +IFK+GDDLR
Sbjct: 726 EALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLR 785
Query: 643 QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVLDTEGSI- 700
QD L LQ+I LMD L ++E LDL++TPY L T + G ++ + +S +A + + ++
Sbjct: 786 QDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMA 845
Query: 701 ------QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKT 754
++ + S+N P ++ + SCAGYCV TY+LG+GDRH DN+++ ++
Sbjct: 846 ATAAFNKDALLNWLKSKN-PGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES 904
Query: 755 GKLFHIDFGYILGR-------DPKPLPPPMKLNKEMVEGMGGT-QSEQYQEFRKQCYTAF 806
G+LFHIDFG+ LG + + +P + + V G T SE+++ FR C A+
Sbjct: 905 GQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAY 964
Query: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
LRR+ L L+LF+LM A +P+++ D ++ ++D L ++EEA+ + + +E+
Sbjct: 965 TILRRHGLLFLHLFALMRAAGLPELSCSKD--IQYLKDSLALGKTEEEALKHFRVKFNEA 1022
Query: 867 V 867
+
Sbjct: 1023 L 1023
Score = 75.1 bits (183), Expect = 3e-13
Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)
Query: 295 QLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQ-EKALTKFLKCVNWDLPQEAKQALELLG 353
QL I+ + +L E+DLVWK R+ + +AL + L W+ ++ Q L LL
Sbjct: 510 QLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLC 569
Query: 354 KWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410
W + V +LELL + + V +A+ LR+ D++L YLLQLVQ LKYE++ D
Sbjct: 570 SWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLD 626
Score = 35.0 bits (79), Expect = 0.31
Identities = 40/189 (21%), Positives = 66/189 (34%), Gaps = 34/189 (17%)
Query: 57 LYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGP 116
L V +F + L V +S + + W + L+ + DLPR A++ ++ V
Sbjct: 341 LVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEK 400
Query: 117 GKAV------------PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTS 164
K P+ + LF + G L +WP+V + E G
Sbjct: 401 AKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVR 460
Query: 165 STLSEDQMS-----------------RLAKLTKAHRQGHMVKVDWLDRLTFREIEMINES 207
S + D + L K+ + R V V ++L REI
Sbjct: 461 SNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREI-----L 515
Query: 208 EKRSSNFMY 216
E+R S +Y
Sbjct: 516 ERRGSGELY 524
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 176 bits (446), Expect = 9e-44
Identities = 127/430 (29%), Positives = 218/430 (50%), Gaps = 36/430 (8%)
Query: 470 NLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALL 529
NLE L L+ R+ ++ +A+ LYW + ++ + + ++ L ++ + L
Sbjct: 769 NLESPLVQLLLHRSLQSIQVAHRLYWLL----KNAENEAYFKSWYQKLLAALQFCAGKAL 824
Query: 530 KGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVE 589
+ S +Q + L + + V+ S ++++ E L+ +G E+ DV
Sbjct: 825 NDEFS---------KEQKLIKILGDIGERVKSASDHQRQ--EVLKKEIGRLEEF-FQDVN 872
Query: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLRQDQLI 647
LPL P + I+GI + + F S +P ++ F + G +IFK GDDLRQD L+
Sbjct: 873 TCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLV 932
Query: 648 LQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVLDTEGSI----QN 702
LQ+I +MD + +E LD+++ Y+ L+T G +Q + +V +A++ G I +N
Sbjct: 933 LQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKEN 992
Query: 703 FFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
+K+ N + + + SCAG+CV+T+ILGV DRH DN++LTK+G +FHIDF
Sbjct: 993 TIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDF 1052
Query: 763 GYILG---------RDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYS 813
G LG RD P ++ + E GG + +Q+F + C A+ +R++S
Sbjct: 1053 GKFLGHAQTFGGIKRDRAPFIFTSEMEYFITE--GGKNPQHFQDFVELCCRAYNIIRKHS 1110
Query: 814 NLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAA 873
L+LNL +M+ A +P+++ D +K V + R +D EA + I ES+
Sbjct: 1111 QLLLNLLEMMLYAGLPELSGIQD--LKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVK 1168
Query: 874 VVEQIHKFAQ 883
+ IH AQ
Sbjct: 1169 LNNLIHTLAQ 1178
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/100 (31%), Positives = 56/100 (56%), Gaps = 2/100 (2%)
Query: 308 LTYEEQDLVWKFRYYLTNQEKALTKFL-KCVNWDLPQEAKQALELLGKWKPMDVEDSLEL 366
L+ E++ +W +R+Y N+ +L L WD + + +L +W ++L L
Sbjct: 669 LSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWD-ERTVSEMHTILRRWTFSQPLEALGL 727
Query: 367 LSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYE 406
L+S + + +R+ AV +L +++LL YL QLVQA+K+E
Sbjct: 728 LTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFE 767
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 173 bits (438), Expect = 7e-43
Identities = 131/437 (29%), Positives = 208/437 (47%), Gaps = 53/437 (12%)
Query: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVM-RRFSQALL 529
L L FL+SRA N +A+ LYW + D R L+V +R + LL
Sbjct: 988 LNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELL 1047
Query: 530 KGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRK-----KKNERLQALLGDNEKMN 584
K K V+++ + + V++ SG+ + + ER+Q+ N+
Sbjct: 1048 KQTKLVQLLGGVA--------------EKVRQASGSARQVVLQRSMERVQSFFQKNK--- 1090
Query: 585 LSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLR 642
LPL+P + + + ++ + F S +P ++ D G + V+FK G+DLR
Sbjct: 1091 ------CRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLR 1144
Query: 643 QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQN 702
QD L LQ+I +MDK+ KE LDL++ +K L+T G ++ + + + E +
Sbjct: 1145 QDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTG 1204
Query: 703 FF---------RKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTK 753
F RKY PSE S + ++ SCAG CV TY+LG+ DRH DN++L
Sbjct: 1205 SFKDKPLAEWLRKYNPSEEEYEKAS----ENFIYSCAGCCVATYVLGICDRHNDNIMLRS 1260
Query: 754 TGKLFHIDFGYILGRDP-----KPLPPPMKLNKEMVEGMGGTQSE--QYQEFRKQCYTAF 806
TG +FHIDFG LG K P L +M + G + ++Q F C A+
Sbjct: 1261 TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY 1320
Query: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
+R+ +NL LNL SLM+ + +P++ D +K V+D + +D EA + LI+ S
Sbjct: 1321 NLIRKQTNLFLNLLSLMIPSGLPELTSIQD--LKYVRDALQPQTTDAEATIFFTRLIESS 1378
Query: 867 VHALFAAVVEQIHKFAQ 883
+ ++ IH AQ
Sbjct: 1379 LGSIATKFNFFIHNLAQ 1395
Score = 53.9 bits (128), Expect = 6e-07
Identities = 36/100 (36%), Positives = 49/100 (49%), Gaps = 2/100 (2%)
Query: 308 LTYEEQDLVWKFRYYLTNQEKALTKFLKCV-NWDLPQEAKQALELLGKWKPMDVEDSLEL 366
L+ E++ +W+ RYY L K L NW AK LL +W + +LEL
Sbjct: 887 LSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAK-TYSLLHQWPALYPLIALEL 945
Query: 367 LSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYE 406
L S + + VR AV + D++L L Q VQALKYE
Sbjct: 946 LDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYE 985
Score = 32.3 bits (72), Expect = 2.0
Identities = 16/60 (26%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 58 YVTCQVFAEGKPLALPVRT----SYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDV 113
Y+ C + GK L P+++ +YK F W+E + P++ LP + + LT++ +
Sbjct: 708 YLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGI 767
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 171 bits (433), Expect = 3e-42
Identities = 128/421 (30%), Positives = 209/421 (49%), Gaps = 47/421 (11%)
Query: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
L+ L FL+ RA N + +L+W++ E + E Y + L K
Sbjct: 652 LDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSK 711
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE-KMNLSDVE 589
+++ +++L + L+ L AV+ NR K E + L + + LSD++
Sbjct: 712 QVEALNKLKTL--------NSLIKL-NAVKL---NRAKGKEAMHTCLKQSAYREALSDLQ 759
Query: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGK--YPVIFKHGDDLRQDQLI 647
PL P V + + E S + P L + + G+ VIFK+GDDLRQD L
Sbjct: 760 S---PLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLT 816
Query: 648 LQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQ------------SVPVAEVLD 695
LQ++ LMD L ++ LDL++ PY LAT + G ++ + S A
Sbjct: 817 LQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAF 876
Query: 696 TEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTG 755
+ ++ N+ ++Y ++ I + + SCAGYCV +Y+LG+GDRH DN+++ KTG
Sbjct: 877 NKDALLNWLKEYNSGDDLDRAI-----EEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTG 931
Query: 756 KLFHIDFGYILG---------RDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAF 806
+LFHIDFG+ILG R+ P + +G G +E++ FR+ C A+
Sbjct: 932 QLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTG-NTEKFGRFRQCCEDAY 990
Query: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
L LRR+ NL + LF+LM+ A +P+ L K ++ ++D L S+EEA+ + DE+
Sbjct: 991 LILRRHGNLFITLFALMLTAGLPE--LTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEA 1048
Query: 867 V 867
+
Sbjct: 1049 L 1049
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/116 (40%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 296 LNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQ-EKALTKFLKCVNWDLPQEAKQALELLGK 354
L I+ P QL E DL+W R ++L K L + W+ ++ Q LL
Sbjct: 538 LKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQI 597
Query: 355 WKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410
W + ++LELL +Y + VR YAV LRQ DE+L YLLQLVQ LKYE F D
Sbjct: 598 WPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLD 653
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 164 bits (415), Expect = 3e-40
Identities = 111/438 (25%), Positives = 219/438 (50%), Gaps = 41/438 (9%)
Query: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
L+ L FL+ +A N + ++ +W++ E ++ QR E Y + + L
Sbjct: 645 LDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHL-- 702
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSD-VE 589
++ V M ++L++L +++E + +K + ++ L+ + + D ++
Sbjct: 703 -NRQVEAM-----------EKLINLTDILKQEKKDETQKVQ-MKFLVEQMRRPDFMDALQ 749
Query: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED------GGKYPVIFKHGDDLRQ 643
PL P ++ + E + SA P L ++ D +IFK+GDDLRQ
Sbjct: 750 GFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQ 809
Query: 644 DQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNF 703
D L LQII +M+ + + + LDL++ PY L+ G ++ +++ + +G ++
Sbjct: 810 DMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGA 869
Query: 704 FRKYAPS------ENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKL 757
+ + + + I +D + +SCAGYCV T+ILG+GDRH N+++ G+L
Sbjct: 870 LQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQL 929
Query: 758 FHIDFGYILGRDPKPL-----PPPMKLNKE--MVEGMGG---TQSEQYQEFRKQCYTAFL 807
FHIDFG+ L K P L ++ +V G T++ +++ F++ CY A+L
Sbjct: 930 FHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYL 989
Query: 808 HLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESV 867
+R+++NL +NLFS+M+ + +P++ D + ++ LD +++EA+ Y ++++
Sbjct: 990 AIRQHANLFINLFSMMLGSGMPELQSFDD--IAYIRKTLALDKTEQEALEYFMKQMNDAH 1047
Query: 868 HALFAAVVEQI-HKFAQY 884
H + ++ I H Q+
Sbjct: 1048 HGGWTTKMDWIFHTIKQH 1065
Score = 85.9 bits (211), Expect = 2e-16
Identities = 47/129 (36%), Positives = 72/129 (55%), Gaps = 3/129 (2%)
Query: 283 DHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLP 342
D++L+ N ++QL I + P ++T +E+D +W R+Y + L K L V W+
Sbjct: 520 DNELREN--DKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSR 577
Query: 343 QEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARL-RQADDEDLLMYLLQLVQ 401
E Q L+ W P+ E ++ELL +Y +P VR +AV L + D+ L YL+QLVQ
Sbjct: 578 DEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQ 637
Query: 402 ALKYENFDD 410
LKYE + D
Sbjct: 638 VLKYEQYLD 646
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 57 LYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGP 116
+YV ++ G+PL V T S WNEWL + PDLPR A++ L+I V G
Sbjct: 354 IYVRTGIYHGGEPLCDNVNTQRVPCSNP-RWNEWLNYDIYIPDLPRAARLCLSICSVKGR 412
Query: 117 GKA----VPVGGTTVSLFGKYGMFRQGMHDLKVWP 147
A P+ ++LF G L +WP
Sbjct: 413 KGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWP 447
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 160 bits (404), Expect = 6e-39
Identities = 119/427 (27%), Positives = 197/427 (46%), Gaps = 32/427 (7%)
Query: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
L+ L FL+ RA + + +Y +W + +D R Y ++ K
Sbjct: 932 LDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIR-------YQYLLAALLCCCGK 984
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVEL 590
G +R Q V+ L L + V+ + + ++ R + K +
Sbjct: 985 G------LREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGL---EEVKQFFALNGS 1035
Query: 591 IPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLRQDQLIL 648
LPL P + ++GI+P + F S +P +L F+ D G VIFK GDDLRQD L L
Sbjct: 1036 CRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTL 1095
Query: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRK-- 706
Q+I +M K+ +E LD+++ ++ +T G ++ I + + E + F+
Sbjct: 1096 QMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRP 1155
Query: 707 ---YAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFG 763
+ N + ++ ++ SCAG CV TY+LG+ DRH DN++L TG +FHIDFG
Sbjct: 1156 LADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFG 1215
Query: 764 YILGR-----DPKPLPPPMKLNKEM--VEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
LG + K P +M V G S ++ +F C A+ +R++++L
Sbjct: 1216 RFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLF 1275
Query: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
LNL LM+ IP+++ D +K V D R ++ A Y LI+ S+ ++ +
Sbjct: 1276 LNLLGLMLSCGIPELSDLED--LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNF 1333
Query: 877 QIHKFAQ 883
IH AQ
Sbjct: 1334 FIHNLAQ 1340
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/107 (36%), Positives = 58/107 (54%), Gaps = 8/107 (7%)
Query: 308 LTYEEQDLVWKFRYYLTNQEKALTKFLKCV-NWD---LPQEAKQALELLGKWKPMDVEDS 363
LT ++ +W+ RYY ++ +L L +W+ LP LL +W M+ +D+
Sbjct: 831 LTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPD----IYVLLKQWTHMNHQDA 886
Query: 364 LELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410
L LL + + + VRR AV + D +LL YL QLVQALKYE + D
Sbjct: 887 LGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLD 933
Score = 35.0 bits (79), Expect = 0.31
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 16/128 (12%)
Query: 49 LYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRW----NWNEWLKLPVKYPDLPRNA 104
++ + D Y++C + GK L P++T FS W++ + PV+ LPR
Sbjct: 644 IWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRET 703
Query: 105 QVALTIW--DVYGPG--------KAVP--VGGTTVSLFGKYGMFRQGMHDLKVWPNVEAD 152
+ T++ + PG + VP +G T LF + G L +WP + +
Sbjct: 704 LLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQEN 763
Query: 153 GSEPTKTP 160
S P
Sbjct: 764 PSARWSAP 771
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 119 bits (297), Expect = 2e-26
Identities = 70/258 (27%), Positives = 137/258 (53%), Gaps = 14/258 (5%)
Query: 633 VIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQ-FIQSVPVA 691
VI K GDDLRQ+ L Q++ + + +E + L + PYK+L S G ++ + +V +
Sbjct: 573 VIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIH 632
Query: 692 EVL-DTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
+V ++ S+ ++F + S +SA+ +V+SCAGYC++ Y+L V DRH N+L
Sbjct: 633 QVKKQSQLSLLDYFLQEHGSYTTEAFLSAQ--RNFVQSCAGYCLVCYLLQVKDRHNGNIL 690
Query: 751 LTKTGKLFHIDFGYILGRDPKPL---PPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFL 807
L G + HIDFG+IL P+ L KL E V+ MGG + + ++ +
Sbjct: 691 LDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLI 750
Query: 808 HLRRYSNLILNLFSLMVD-ANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
R++ + ++ + +M + +P T++ ++++F + +++E+ +Q L+++
Sbjct: 751 AARKHMDKVVQIVEIMQQGSQLP--CFHGSSTIRNLKERFHMSMTEEQ----LQLLVEQM 804
Query: 867 VHALFAAVVEQIHKFAQY 884
V ++ +++ QY
Sbjct: 805 VDGSMRSITTKLYDGFQY 822
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
[Homo sapiens]
Length = 854
Score = 116 bits (291), Expect = 8e-26
Identities = 72/237 (30%), Positives = 125/237 (52%), Gaps = 13/237 (5%)
Query: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693
IFK GDD RQD L LQII L + + LDL + PY+V+AT+ G ++ I +
Sbjct: 600 IFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 659
Query: 694 LDTE---GSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
L + G F R+Y + +++S A Y ++ ++L + DRH N++
Sbjct: 660 LGRQTDFGMYDYFTRQYGDES---TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 716
Query: 751 LTKTGKLFHIDFGYILGRDP---KPLPPPMKLNKEMVEGMGG-TQSEQYQEFRKQCYTAF 806
L K G + HIDFG++ P P +KL EMV MGG ++ ++ F + C +
Sbjct: 717 LDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGY 776
Query: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLI 863
L +R Y + +++L +LM+D +P +T+K ++ +F ++++ EA +++ +I
Sbjct: 777 LAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKHRFSPNMTEREAANFIMKVI 830
Score = 39.3 bits (90), Expect = 0.016
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 3/106 (2%)
Query: 332 KFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYT-NPTVRRYAVARLRQADDE 390
KFL V W L + W P D L SS Y +P +Y V LR +
Sbjct: 343 KFL--VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPD 400
Query: 391 DLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGIN 436
+L Y+ Q+VQAL+Y+ ++ + SQ + + N N
Sbjct: 401 AILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTN 446
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 116 bits (291), Expect = 8e-26
Identities = 72/237 (30%), Positives = 125/237 (52%), Gaps = 13/237 (5%)
Query: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693
IFK GDD RQD L LQII L + + LDL + PY+V+AT+ G ++ I +
Sbjct: 1790 IFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 1849
Query: 694 LDTE---GSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
L + G F R+Y + +++S A Y ++ ++L + DRH N++
Sbjct: 1850 LGRQTDFGMYDYFTRQYGDES---TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 1906
Query: 751 LTKTGKLFHIDFGYILGRDP---KPLPPPMKLNKEMVEGMGG-TQSEQYQEFRKQCYTAF 806
L K G + HIDFG++ P P +KL EMV MGG ++ ++ F + C +
Sbjct: 1907 LDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGY 1966
Query: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLI 863
L +R Y + +++L +LM+D +P +T+K ++ +F ++++ EA +++ +I
Sbjct: 1967 LAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKHRFSPNMTEREAANFIMKVI 2020
Score = 39.3 bits (90), Expect = 0.016
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 3/106 (2%)
Query: 332 KFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYT-NPTVRRYAVARLRQADDE 390
KFL V W L + W P D L SS Y +P +Y V LR +
Sbjct: 1533 KFL--VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPD 1590
Query: 391 DLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGIN 436
+L Y+ Q+VQAL+Y+ ++ + SQ + + N N
Sbjct: 1591 AILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTN 1636
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 80.9 bits (198), Expect = 5e-15
Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 6/140 (4%)
Query: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693
IFK GDD RQD L LQII L + + LDL + PY+V+AT+ G ++ I +
Sbjct: 54 IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
Query: 694 LDTE---GSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
L + G F R+Y + +++S A Y ++ ++L + DRH N++
Sbjct: 114 LGRQTDFGMYDYFTRQYGDES---TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 170
Query: 751 LTKTGKLFHIDFGYILGRDP 770
L K G + HIDFG++ P
Sbjct: 171 LDKKGHIIHIDFGFMFESSP 190
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 72.4 bits (176), Expect = 2e-12
Identities = 74/307 (24%), Positives = 127/307 (41%), Gaps = 57/307 (18%)
Query: 627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK--ENLDLKLT--PYKVLATSTKHGFM 682
DG + + K DDLRQD ++ Q+ + + LL++ E KLT YKV+ S + G +
Sbjct: 1360 DGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 1419
Query: 683 QFIQ-SVPVAEVL-----------------------------------------DTEGSI 700
++ +VP+ E L D +
Sbjct: 1420 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 1479
Query: 701 QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFH 759
Q FR + + I E Y +S A ++ YILG+GDRH+ N+L+ ++ +L H
Sbjct: 1480 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 1539
Query: 760 IDFGYILGRD---PKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
ID G + P P P +L +++V+GMG T E FR+ C +R +
Sbjct: 1540 IDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETL 1597
Query: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
L + +++ + D + P K + Q DE +H + D+ + + +
Sbjct: 1598 LTIVEVLLYDPLFDWTMNPLKALYLQQRP-----EDETELHPTLNADDQECKRNLSDIDQ 1652
Query: 877 QIHKFAQ 883
+K A+
Sbjct: 1653 SFNKVAE 1659
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 72.4 bits (176), Expect = 2e-12
Identities = 74/307 (24%), Positives = 127/307 (41%), Gaps = 57/307 (18%)
Query: 627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK--ENLDLKLT--PYKVLATSTKHGFM 682
DG + + K DDLRQD ++ Q+ + + LL++ E KLT YKV+ S + G +
Sbjct: 2708 DGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2767
Query: 683 QFIQ-SVPVAEVL-----------------------------------------DTEGSI 700
++ +VP+ E L D +
Sbjct: 2768 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2827
Query: 701 QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFH 759
Q FR + + I E Y +S A ++ YILG+GDRH+ N+L+ ++ +L H
Sbjct: 2828 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2887
Query: 760 IDFGYILGRD---PKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
ID G + P P P +L +++V+GMG T E FR+ C +R +
Sbjct: 2888 IDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETL 2945
Query: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
L + +++ + D + P K + Q DE +H + D+ + + +
Sbjct: 2946 LTIVEVLLYDPLFDWTMNPLKALYLQQRP-----EDETELHPTLNADDQECKRNLSDIDQ 3000
Query: 877 QIHKFAQ 883
+K A+
Sbjct: 3001 SFNKVAE 3007
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 72.0 bits (175), Expect = 2e-12
Identities = 77/340 (22%), Positives = 138/340 (40%), Gaps = 55/340 (16%)
Query: 594 PLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISL 653
P +P ++I+ I P + S P +L +G ++ + K +DLRQD+ ++Q+ L
Sbjct: 2146 PNQPIIRIQSIAPSLQVI-TSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGL 2204
Query: 654 MDKLLRKENLDLK----LTPYKVLATSTKHGFMQFIQSVPVAE------------VLDTE 697
++ LL + L+ + Y V+ ST G + ++ +L+ E
Sbjct: 2205 VNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIE 2264
Query: 698 GSIQ----------NFFRKYAPSENGPNGISAEVM------------------DTYVKSC 729
I +K E+ N + + + Y +S
Sbjct: 2265 HRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL 2324
Query: 730 AGYCVITYILGVGDRHLDNLLLTK-TGKLFHIDFG----YILGRDPKPLPPPMKLNKEMV 784
A ++ YILG+GDRH NL+L + +GK+ HIDFG + R+ P P +L + +
Sbjct: 2325 AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT 2384
Query: 785 EGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQD 844
M T + +R C+T LR + + ++ + V + + L T +
Sbjct: 2385 NAMEVTGLD--GNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRS 2442
Query: 845 KFRLD-LSDEEAVHYMQSL-IDESVHALFAAVV-EQIHKF 881
+ R D S ++V + + + E H V E IH F
Sbjct: 2443 RTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSF 2482
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 71.6 bits (174), Expect = 3e-12
Identities = 74/307 (24%), Positives = 126/307 (41%), Gaps = 57/307 (18%)
Query: 627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK--ENLDLKLT--PYKVLATSTKHGFM 682
DG + + K DDLRQD ++ Q+ + + LL++ E KLT YKV+ S + G +
Sbjct: 2586 DGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2645
Query: 683 QFIQ-SVPVAEVL-----------------------------------------DTEGSI 700
++ +VP+ E L D +
Sbjct: 2646 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2705
Query: 701 QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFH 759
Q FR + + I E Y +S A ++ YILG+GDRH+ N+L+ ++ +L H
Sbjct: 2706 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2765
Query: 760 IDFGYILGRD---PKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
ID G + P P P +L +++V+GMG T E FR+ C +R +
Sbjct: 2766 IDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETL 2823
Query: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
L + +++ + D + P K + Q DE +H + D+ + + +
Sbjct: 2824 LTIVEVLLYDPLFDWTMNPLKALYLQQRP-----EDETELHPTLNADDQECKRNLSDIDQ 2878
Query: 877 QIHKFAQ 883
K A+
Sbjct: 2879 SFDKVAE 2885
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 68.2 bits (165), Expect = 3e-11
Identities = 70/284 (24%), Positives = 119/284 (41%), Gaps = 41/284 (14%)
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKK-----KNERLQALLGDNEKMNL 585
G +++R L+ + L+ M + GN K+ + +++ L + E
Sbjct: 3645 GKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQ 3704
Query: 586 SDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQ 645
D PLP E V+I G E T+ S P ++ + D ++P + K G+DLRQDQ
Sbjct: 3705 YDGRGKPLP-EYHVRIAGF-DERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQ 3762
Query: 646 LILQIISLMDKLLRKENL----DLKLTPYKVL-------------------ATSTKHGFM 682
+ Q+ +M+ +L +++ L+L Y V+ S KH
Sbjct: 3763 RVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVG 3822
Query: 683 QFIQSVPVAEVLDTEGSIQN---------FFRKYAPSENGPNGISAEVMDTYVKSCAGYC 733
++ A +T S + R + P A + + S A C
Sbjct: 3823 AYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLA-LRSHFASSHALIC 3881
Query: 734 VITYILGVGDRHLDNLLLT-KTGKLFHIDFGYILGRDPKPLPPP 776
+ +ILG+GDRHL+N ++ +TG + IDFG+ G + LP P
Sbjct: 3882 ISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3925
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 68.2 bits (165), Expect = 3e-11
Identities = 70/284 (24%), Positives = 119/284 (41%), Gaps = 41/284 (14%)
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKK-----KNERLQALLGDNEKMNL 585
G +++R L+ + L+ M + GN K+ + +++ L + E
Sbjct: 3644 GKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQ 3703
Query: 586 SDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQ 645
D PLP E V+I G E T+ S P ++ + D ++P + K G+DLRQDQ
Sbjct: 3704 YDGRGKPLP-EYHVRIAGF-DERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQ 3761
Query: 646 LILQIISLMDKLLRKENL----DLKLTPYKVL-------------------ATSTKHGFM 682
+ Q+ +M+ +L +++ L+L Y V+ S KH
Sbjct: 3762 RVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVG 3821
Query: 683 QFIQSVPVAEVLDTEGSIQN---------FFRKYAPSENGPNGISAEVMDTYVKSCAGYC 733
++ A +T S + R + P A + + S A C
Sbjct: 3822 AYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLA-LRSHFASSHALIC 3880
Query: 734 VITYILGVGDRHLDNLLLT-KTGKLFHIDFGYILGRDPKPLPPP 776
+ +ILG+GDRHL+N ++ +TG + IDFG+ G + LP P
Sbjct: 3881 ISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3924
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/239 (24%), Positives = 102/239 (42%), Gaps = 51/239 (21%)
Query: 611 LFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLK 666
+ S P ++ K DG Y ++ K DDLR+D +++ SL++K LRK+ +L
Sbjct: 2302 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELH 2361
Query: 667 LTPYKVLATSTKHGFMQFIQSV----PVAEVLDTEGSIQ--------------------- 701
+ Y V+ + + G ++++ + P+ L E +
Sbjct: 2362 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKL 2421
Query: 702 NFFRKYAPSENGP--------------NGISAEVMDTYVKSCAGYCVITYILGVGDRHLD 747
FR++ + P + S+ Y +S A ++ YILG+GDRH +
Sbjct: 2422 KVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSR--SAYCRSTAVMSMVGYILGLGDRHGE 2479
Query: 748 NLLL-TKTGKLFHIDFGYILGRDPK---PLPPPMKLNKEMVEGMGGTQSEQYQEFRKQC 802
N+L + TG+ H+DF + + P P +L MV GMG +E FR+ C
Sbjct: 2480 NILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGL--FRRAC 2536
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/239 (24%), Positives = 102/239 (42%), Gaps = 51/239 (21%)
Query: 611 LFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLK 666
+ S P ++ K DG Y ++ K DDLR+D +++ SL++K LRK+ +L
Sbjct: 44 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELH 103
Query: 667 LTPYKVLATSTKHGFMQFIQSV----PVAEVLDTEGSIQ--------------------- 701
+ Y V+ + + G ++++ + P+ L E +
Sbjct: 104 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKL 163
Query: 702 NFFRKYAPSENGP--------------NGISAEVMDTYVKSCAGYCVITYILGVGDRHLD 747
FR++ + P + S+ Y +S A ++ YILG+GDRH +
Sbjct: 164 KVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSR--SAYCRSTAVMSMVGYILGLGDRHGE 221
Query: 748 NLLL-TKTGKLFHIDFGYILGRDPK---PLPPPMKLNKEMVEGMGGTQSEQYQEFRKQC 802
N+L + TG+ H+DF + + P P +L MV GMG +E FR+ C
Sbjct: 222 NILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGL--FRRAC 278
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/110 (32%), Positives = 53/110 (48%), Gaps = 10/110 (9%)
Query: 721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLL-TKTGKLFHIDFGYILG-----RDPKPLP 774
V +Y +S A ++ YI+G+GDRHLDN+L+ TG++ HID+ R P+ +P
Sbjct: 2313 VTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVP 2372
Query: 775 PPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMV 824
M N E G+ G + FR C +RR +L L V
Sbjct: 2373 FRMTQNIETALGVTGVEG----VFRLSCEQVLHIMRRGRETLLTLLEAFV 2418
Score = 45.1 bits (105), Expect = 3e-04
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
Query: 608 TATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLL----RKENL 663
T T+ + P +L F DG YP +FK +DL D+ I+Q +S+++ + R+E
Sbjct: 2127 TITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETP 2186
Query: 664 DLKLTPYKVLATSTKHGFMQFI 685
Y V T+ G +Q++
Sbjct: 2187 RFHARHYSVTPLGTRSGLIQWV 2208
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 50.1 bits (118), Expect = 9e-06
Identities = 40/166 (24%), Positives = 81/166 (48%), Gaps = 11/166 (6%)
Query: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKK-----KNERLQALLGDNEKMNL 585
G +++R L+ + L+ M + GN K+ + +++ L + E
Sbjct: 3645 GKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQ 3704
Query: 586 SDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQ 645
D PLP E V+I G E T+ S P ++ + D ++P + K G+DLRQDQ
Sbjct: 3705 YDGRGKPLP-EYHVRIAGF-DERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQ 3762
Query: 646 LILQIISLMDKLLRKENL----DLKLTPYKVLATSTKHGFMQFIQS 687
+ Q+ +M+ +L +++ L+L Y V+ +++ G ++++++
Sbjct: 3763 RVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLEN 3808
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/53 (41%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 725 YVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFHIDFGYILGRDPKPLPPP 776
+ S A C+ +ILG+GDRHL+N ++ +TG + IDFG+ G + LP P
Sbjct: 3904 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3956
>gi|5454140 tumor susceptibility gene 101 [Homo sapiens]
Length = 390
Score = 36.2 bits (82), Expect = 0.14
Identities = 52/224 (23%), Positives = 90/224 (40%), Gaps = 47/224 (20%)
Query: 455 SPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTH 514
S PP + DG E + LIS +++ L W + E+ D Q +
Sbjct: 206 SQPPVTTVGPSRDGTISEDTIRASLIS------AVSDKLRWRMK---EEMDRAQAE---- 252
Query: 515 EMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQ 574
LN ++R + L KG + + M + L + VD+ + L+ KKK+E L
Sbjct: 253 ---LNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELL----------KKKDEELS 299
Query: 575 ALLG--DNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYP 632
+ L +N+ N +D++ + +P TA L+K L E+
Sbjct: 300 SALEKMENQSEN-NDIDEVIIP-------------TAPLYKQILN-----LYAEENAIED 340
Query: 633 VIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATS 676
IF G+ LR+ + L + +LL ++ L+ K T+
Sbjct: 341 TIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTA 384
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 33.9 bits (76), Expect = 0.69
Identities = 20/77 (25%), Positives = 34/77 (44%)
Query: 500 ECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAV 559
EC + Q + E + F+ + + DK R Q VDRL+ ++K V
Sbjct: 677 ECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEV 736
Query: 560 QRESGNRKKKNERLQAL 576
+ E ++ KK L++L
Sbjct: 737 ENEKNDKDKKIAELESL 753
>gi|118442841 hypothetical protein LOC123591 [Homo sapiens]
Length = 531
Score = 32.0 bits (71), Expect = 2.6
Identities = 44/183 (24%), Positives = 72/183 (39%), Gaps = 35/183 (19%)
Query: 322 YLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSL-ELLSSHYTNPT----V 376
++ +Q ++ K L+ WD A+ +E L + ++D + +S +Y P+ V
Sbjct: 285 HVLSQPRSRFKVLEAGTWDEETAAESVVEELQPSQEATMKDDMNSYISQYYNGPSSDSGV 344
Query: 377 RRYAVARLRQA----DDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSN 432
AV + A ++ L L LK + S+ SE+ S
Sbjct: 345 PEPAVCMVTTAAIDIHQPNISSDLFSLDMPLKLGG-------------NGTSATSESASR 391
Query: 433 SGINSAEIDSSQIITSPL--------PSVS---SPPPASKTKEVPDGENLEQDLCTFLIS 481
S + A+ DSSQ + S + PS SPPP ++V E QDL + L
Sbjct: 392 SSVTRAQSDSSQTLGSSMDCSTAREEPSSEPGPSPPPLPSQQQVE--EATVQDLLSSLSE 449
Query: 482 RAC 484
C
Sbjct: 450 DPC 452
>gi|116268113 transmembrane protein 99 [Homo sapiens]
Length = 258
Score = 32.0 bits (71), Expect = 2.6
Identities = 14/44 (31%), Positives = 21/44 (47%)
Query: 85 WNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVS 128
W W L ++ L + + VA + + GPG VPV G + S
Sbjct: 112 WTGGSWFSLHLQQVSLSQGSHVAAFLPEAIGPGVPVPVSGESTS 155
>gi|27501450 axin 1 isoform a [Homo sapiens]
Length = 862
Score = 31.2 bits (69), Expect = 4.5
Identities = 15/49 (30%), Positives = 27/49 (55%)
Query: 533 KSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE 581
++ RV + + Q F + L+H ++AVQR +K ERL+ + + E
Sbjct: 373 RTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEE 421
>gi|31083144 axin 1 isoform b [Homo sapiens]
Length = 826
Score = 31.2 bits (69), Expect = 4.5
Identities = 15/49 (30%), Positives = 27/49 (55%)
Query: 533 KSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE 581
++ RV + + Q F + L+H ++AVQR +K ERL+ + + E
Sbjct: 373 RTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEE 421
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 31.2 bits (69), Expect = 4.5
Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 391 DLLMYLLQLVQALKYEN--FDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQII 446
DL+ + L ALK E + +K G + + + ++ VSE VSN + S +++S ++
Sbjct: 113 DLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLV 170
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 31.2 bits (69), Expect = 4.5
Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 391 DLLMYLLQLVQALKYEN--FDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQII 446
DL+ + L ALK E + +K G + + + ++ VSE VSN + S +++S ++
Sbjct: 113 DLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLV 170
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,748,246
Number of Sequences: 37866
Number of extensions: 1538383
Number of successful extensions: 5309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 5187
Number of HSP's gapped (non-prelim): 96
length of query: 887
length of database: 18,247,518
effective HSP length: 111
effective length of query: 776
effective length of database: 14,044,392
effective search space: 10898448192
effective search space used: 10898448192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.