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Search of human proteins with 124028512
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124028512 WD40-repeat protein upregulated in HCC isoform b
[Homo sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 1268 0.0
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H... 1083 0.0
gi|94400919 WD repeat domain 90 [Homo sapiens] 112 1e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 94 5e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 94 5e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 1e-16
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 82 2e-15
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 82 2e-15
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 80 4e-15
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 80 4e-15
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 77 5e-14
gi|26665869 WD repeat domain 51B [Homo sapiens] 77 5e-14
gi|223005862 echinoderm microtubule associated protein like 6 [H... 75 2e-13
gi|16554629 WD repeat domain 5 [Homo sapiens] 74 5e-13
gi|16554627 WD repeat domain 5 [Homo sapiens] 74 5e-13
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 70 8e-12
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 70 8e-12
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 69 1e-11
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 69 2e-11
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 69 2e-11
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 69 2e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 69 2e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 69 2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 68 2e-11
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 68 2e-11
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 68 3e-11
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 68 3e-11
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 68 3e-11
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 67 5e-11
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 67 5e-11
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 1268 bits (3280), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFL 60
MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFL
Sbjct: 1 MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFL 60
Query: 61 QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFS 120
QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFS
Sbjct: 61 QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFS 120
Query: 121 PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNG 180
PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNG
Sbjct: 121 PNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNG 180
Query: 181 TIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLT 240
TIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLT
Sbjct: 181 TIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLT 240
Query: 241 DVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRG 300
DVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRG
Sbjct: 241 DVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRG 300
Query: 301 EGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWH 360
EGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWH
Sbjct: 301 EGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWH 360
Query: 361 TSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV 420
TSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV
Sbjct: 361 TSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV 420
Query: 421 TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTAS 480
TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTAS
Sbjct: 421 TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTAS 480
Query: 481 TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 540
TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL
Sbjct: 481 TDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 540
Query: 541 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 600
EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ
Sbjct: 541 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 600
Query: 601 YIVSVSADGAILRWKYPYTS 620
YIVSVSADGAILRWKYPYTS
Sbjct: 601 YIVSVSADGAILRWKYPYTS 620
>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
sapiens]
Length = 552
Score = 1083 bits (2800), Expect = 0.0
Identities = 531/534 (99%), Positives = 532/534 (99%), Gaps = 1/534 (0%)
Query: 87 MGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD 146
+GF DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD
Sbjct: 20 IGFN-DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD 78
Query: 147 AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR 206
AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR
Sbjct: 79 AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR 138
Query: 207 IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV 266
IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV
Sbjct: 139 IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV 198
Query: 267 GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL 326
GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL
Sbjct: 199 GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL 258
Query: 327 IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG 386
IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG
Sbjct: 259 IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG 318
Query: 387 KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 446
KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI
Sbjct: 319 KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 378
Query: 447 GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ 506
GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ
Sbjct: 379 GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ 438
Query: 507 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND
Sbjct: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
Query: 567 HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 620
HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS
Sbjct: 499 HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 552
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 112 bits (279), Expect = 1e-24
Identities = 134/650 (20%), Positives = 247/650 (38%), Gaps = 61/650 (9%)
Query: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
L L VIGF GH PD ++YP +++ ++T EQ F GH + VS LA+
Sbjct: 359 LRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALD 418
Query: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPD 133
S +AS Q LWD++ L + +L+FS + L +G
Sbjct: 419 GSSSLLASAQARAPSVMR---LWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDH 475
Query: 134 DGS--VVVWSIAK-----RDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 186
G VV W + + +V F R + G G++R+W
Sbjct: 476 HGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETR---MASCGQGSVRLWR 532
Query: 187 LDLPNRKIWPT---ECQTGQLKRIVMSIGVDD----DDSFFYLGTTTGDILKMNPRTKLL 239
L + P E Q + D + ++ + +G IL+++ + ++
Sbjct: 533 LRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVV 592
Query: 240 TDVG------------PAKDKFSLGVS-AIRCLKMGGLL--VGSGAGLLVFCKSPGYKPI 284
P K FS G AI L + + VGS G L +
Sbjct: 593 RHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVL 652
Query: 285 KKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGT 344
+ + +G ++S+ + +G + L T H+ + ++A H V +
Sbjct: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
Query: 345 AELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPE 404
+L + +R+W ++ ++L T + F + ++ G +R+F+ E
Sbjct: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLE 772
Query: 405 TGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQK-------LEEAL 457
++ V + HR VT + T D + + S +G + Q C + +
Sbjct: 773 AAEVL-VEHTCHRGAVTGLTATPDGRLLFSSCSQGSLA--QYSCADPQWHVLRVAADMVC 829
Query: 458 KEHKSSVSCIRVKRNNEECV-------TASTDGTCIIWDLVRLRRNQMILANTLFQ---C 507
+ +S S + V R+ T + G+ + +L+R+ + LA++
Sbjct: 830 PDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMA 889
Query: 508 VCYHPEEF-QIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
VC+ P ++ S + ++ + G +IREL G + ++++ F+
Sbjct: 890 VCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDA-RFLLIAAG 948
Query: 567 HLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
+KVWDY V +GHS + + SP Q + +SA A+ W
Sbjct: 949 RTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQV--LSAGDAVFLW 996
Score = 108 bits (270), Expect = 1e-23
Identities = 121/514 (23%), Positives = 206/514 (40%), Gaps = 61/514 (11%)
Query: 7 PEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNN 66
P A L L AV+G++G+ + PD Y G V+++ +++ Q GH
Sbjct: 1101 PPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAE 1160
Query: 67 VSCLAISRSGEYIASGQ-VTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLY 125
+S LA+S S + +AS + I +WD + H + ALAFSP+D
Sbjct: 1161 ISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRL 1220
Query: 126 LVSLGGPDDGSVVVWSIAKRDAICGS----PAAGLNVGNATNVIFSRCRDEMFMTAGNGT 181
LV+LG D ++ +W A D + + P G V F+ G GT
Sbjct: 1221 LVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHG--------VAFNPWDAGELTCVGQGT 1272
Query: 182 IRVWELD--------LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMN 233
+ W L R+ P G+L + Y GT++G + +
Sbjct: 1273 VTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-----PPLLYCGTSSGQVCVWD 1327
Query: 234 PRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLL----------VFCKSPGYKP 283
R A D G + L+ GS G L + CK G
Sbjct: 1328 TRAGRCFLSWEADD----GGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASS 1383
Query: 284 I---KKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVF 340
+ ++ L G + S + +VGT ++ VS+ + T + + H V ++VF
Sbjct: 1384 VFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVF 1443
Query: 341 PFGTAELFATCAKK-DIRVWHTSSNRELLRITVPNMTCHGIDF------MRDGKSIISAW 393
G + ATC++ +RVW +S +++ V N +C + + + + + + +
Sbjct: 1444 SPGESHC-ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGY 1502
Query: 394 NDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKL 453
DG +R F+ + M + + H + +T +A ++D + V+SG +G V V C T
Sbjct: 1503 GDGSLRIFS-VSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV-SHPC-TGTT 1559
Query: 454 EEALKEHKS---SVSCIRVKRNNEECVTASTDGT 484
L +H+ S C+ K EC +GT
Sbjct: 1560 FRVLSDHQGAPISTICVTCK----ECEDLGVEGT 1589
Score = 31.2 bits (69), Expect = 3.0
Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 6/83 (7%)
Query: 535 TVIRELEGSLSGSINGM---DITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNIT 591
+V E E L G++ D GV T G V + EG T + GH +
Sbjct: 1383 SVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVS---WAEGTSTRLISGHRSKVN 1439
Query: 592 RIRISPGNQYIVSVSADGAILRW 614
+ SPG + + S DG++ W
Sbjct: 1440 EVVFSPGESHCATCSEDGSVRVW 1462
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 93.6 bits (231), Expect = 5e-19
Identities = 69/286 (24%), Positives = 116/286 (40%), Gaps = 5/286 (1%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H DAV + F T +L + + VWH R T ++F G +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
S D +R + P V AH V ++ SD + ++ + V+VW
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFR-AHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHR 134
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VC 509
QK +L +H + V C + + V+AS D T +WD + F V
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 510 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 569
+HP I +G D + W+V +++ + S ++NG+ G + +T +D +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTL 253
Query: 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
K+ D EG + + GH G T + S +Y S +D ++ WK
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 329 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 388
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 389 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 448
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 174
Query: 449 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 506
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 233
Query: 507 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 292
Query: 567 HLVKVWDYN-----EGEVTHV 582
V VW N GEVT V
Sbjct: 293 EQVMVWKSNFDIVDHGEVTKV 313
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCYH 511
LE K H+ +V+C+ N ++ + S D ++W + R + CV +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 512 PEEFQIITSGTDRKIAYW---EVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 568
P + + D+ + W + TV R + + ++ + +G FVT +D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFR----AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 569 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
VKVW + + H + + SP + IVS S D + W
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 38.5 bits (88), Expect = 0.019
Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 63 HGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPN 122
HG V+ + SG IA+ G + +WD + LL LH + L+F P+
Sbjct: 186 HGGFVTYVDFHPSGTCIAAA-----GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 123 DLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTI 182
YL++ D ++ + + + + + G AT V FSR + + +
Sbjct: 241 GNYLIT--ASSDSTLKILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 183 RVWE 186
VW+
Sbjct: 296 MVWK 299
Score = 36.6 bits (83), Expect = 0.071
Identities = 33/131 (25%), Positives = 61/131 (46%), Gaps = 14/131 (10%)
Query: 57 QNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEA 116
+ +GH + V+C+ S + + +ASG + + +++W K + R + HK +
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMD-----SCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 117 LAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD-EMFM 175
+ FSP+ L S G D +V +W + S + +V F C D + F+
Sbjct: 67 VNFSPSGHLLAS--GSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHF--CSDGQSFV 119
Query: 176 TAGNG-TIRVW 185
TA + T++VW
Sbjct: 120 TASDDKTVKVW 130
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/92 (28%), Positives = 36/92 (39%), Gaps = 10/92 (10%)
Query: 54 TKEQNFL---QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLH 110
T Q FL H N V C S G I S + LWD +RE + H
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD-----KTVKLWDKSSRECVHSYCEH 186
Query: 111 KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSI 142
G + + F P+ + + G D +V VW +
Sbjct: 187 GGFVTYVDFHPSGTCIAAAG--MDNTVKVWDV 216
Score = 31.2 bits (69), Expect = 3.0
Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 29 GLKCHPDQEHMIYPLGCTVL--IQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTF 86
GL HP ++I + L + + + L GH + +A SR+GEY ASG
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG---- 289
Query: 87 MGFKADIILW 96
G +++W
Sbjct: 290 -GSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 93.6 bits (231), Expect = 5e-19
Identities = 69/286 (24%), Positives = 116/286 (40%), Gaps = 5/286 (1%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H DAV + F T +L + + VWH R T ++F G +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
S D +R + P V AH V ++ SD + ++ + V+VW
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFR-AHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHR 134
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VC 509
QK +L +H + V C + + V+AS D T +WD + F V
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 510 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 569
+HP I +G D + W+V +++ + S ++NG+ G + +T +D +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTL 253
Query: 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
K+ D EG + + GH G T + S +Y S +D ++ WK
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 329 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 388
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 389 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 448
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 174
Query: 449 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 506
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 233
Query: 507 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 292
Query: 567 HLVKVWDYN-----EGEVTHV 582
V VW N GEVT V
Sbjct: 293 EQVMVWKSNFDIVDHGEVTKV 313
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCYH 511
LE K H+ +V+C+ N ++ + S D ++W + R + CV +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 512 PEEFQIITSGTDRKIAYW---EVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 568
P + + D+ + W + TV R + + ++ + +G FVT +D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFR----AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 569 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
VKVW + + H + + SP + IVS S D + W
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 38.5 bits (88), Expect = 0.019
Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 63 HGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPN 122
HG V+ + SG IA+ G + +WD + LL LH + L+F P+
Sbjct: 186 HGGFVTYVDFHPSGTCIAAA-----GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 123 DLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTI 182
YL++ D ++ + + + + + G AT V FSR + + +
Sbjct: 241 GNYLIT--ASSDSTLKILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQV 295
Query: 183 RVWE 186
VW+
Sbjct: 296 MVWK 299
Score = 36.6 bits (83), Expect = 0.071
Identities = 33/131 (25%), Positives = 61/131 (46%), Gaps = 14/131 (10%)
Query: 57 QNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEA 116
+ +GH + V+C+ S + + +ASG + + +++W K + R + HK +
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMD-----SCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 117 LAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD-EMFM 175
+ FSP+ L S G D +V +W + S + +V F C D + F+
Sbjct: 67 VNFSPSGHLLAS--GSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHF--CSDGQSFV 119
Query: 176 TAGNG-TIRVW 185
TA + T++VW
Sbjct: 120 TASDDKTVKVW 130
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/92 (28%), Positives = 36/92 (39%), Gaps = 10/92 (10%)
Query: 54 TKEQNFL---QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLH 110
T Q FL H N V C S G I S + LWD +RE + H
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD-----KTVKLWDKSSRECVHSYCEH 186
Query: 111 KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSI 142
G + + F P+ + + G D +V VW +
Sbjct: 187 GGFVTYVDFHPSGTCIAAAG--MDNTVKVWDV 216
Score = 31.2 bits (69), Expect = 3.0
Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 29 GLKCHPDQEHMIYPLGCTVL--IQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTF 86
GL HP ++I + L + + + L GH + +A SR+GEY ASG
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG---- 289
Query: 87 MGFKADIILW 96
G +++W
Sbjct: 290 -GSDEQVMVW 298
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.5 bits (210), Expect = 1e-16
Identities = 62/261 (23%), Positives = 106/261 (40%), Gaps = 5/261 (1%)
Query: 356 IRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 415
+ VWH R T ++F G + S D +R + P V A
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR-A 63
Query: 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 475
H V ++ SD + ++ + V+VW QK +L +H + V C + +
Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWEVFDG 534
V+AS D T +WD + F V +HP I +G D + W+V
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 535 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIR 594
+++ + S ++NG+ G + +T +D +K+ D EG + + GH G T +
Sbjct: 182 RLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 595 ISPGNQYIVSVSADGAILRWK 615
S +Y S +D ++ WK
Sbjct: 241 FSRTGEYFASGGSDEQVMVWK 261
Score = 73.9 bits (180), Expect = 4e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 329 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 388
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 389 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 448
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 136
Query: 449 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 506
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 195
Query: 507 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 254
Query: 567 HLVKVWDYN-----EGEVTHV 582
V VW N GEVT V
Sbjct: 255 EQVMVWKSNFDIVDHGEVTKV 275
Score = 38.5 bits (88), Expect = 0.019
Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 63 HGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPN 122
HG V+ + SG IA+ G + +WD + LL LH + L+F P+
Sbjct: 148 HGGFVTYVDFHPSGTCIAAA-----GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 202
Query: 123 DLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTI 182
YL++ D ++ + + + + + G AT V FSR + + +
Sbjct: 203 GNYLIT--ASSDSTLKILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQV 257
Query: 183 RVWE 186
VW+
Sbjct: 258 MVWK 261
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/92 (28%), Positives = 36/92 (39%), Gaps = 10/92 (10%)
Query: 54 TKEQNFL---QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLH 110
T Q FL H N V C S G I S + LWD +RE + H
Sbjct: 94 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD-----KTVKLWDKSSRECVHSYCEH 148
Query: 111 KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSI 142
G + + F P+ + + G D +V VW +
Sbjct: 149 GGFVTYVDFHPSGTCIAAAG--MDNTVKVWDV 178
Score = 31.2 bits (69), Expect = 3.0
Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 29 GLKCHPDQEHMIYPLGCTVL--IQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTF 86
GL HP ++I + L + + + L GH + +A SR+GEY ASG
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG---- 251
Query: 87 MGFKADIILW 96
G +++W
Sbjct: 252 -GSDEQVMVW 260
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 81.6 bits (200), Expect = 2e-15
Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 11/186 (5%)
Query: 6 SPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLI-QAINTKEQNFLQGHG 64
S E + L+ V+G +GL C P H+ Y GC V+I K+Q+
Sbjct: 52 SEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTAR 111
Query: 65 NNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDL 124
++S LA S G+YI +G+ G + + +WD + + +A + HK + +AFSPN
Sbjct: 112 KSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMK 168
Query: 125 YLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD-EMFMTAGNGTIR 183
++VS+G D + VW K+D + S V + S D F+T GN +R
Sbjct: 169 HIVSMGYQHDMVLNVWD-WKKDIVVASNKVSCRV-----IALSFSEDSSYFVTVGNRHVR 222
Query: 184 VWELDL 189
W L++
Sbjct: 223 FWFLEV 228
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/171 (20%), Positives = 70/171 (40%), Gaps = 9/171 (5%)
Query: 453 LEEALKEHKSSVSCIRVKRNNE-ECVTASTDGTCIIW------DLVRLRRNQMILANTLF 505
LE+ L +H SS++ I+ N + + ++ D + D + R + T
Sbjct: 572 LEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTL 631
Query: 506 QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS--GSINGMDITQEGVHFVTG 563
+ + + + DR + + +G + +GS GS+ + + G T
Sbjct: 632 YDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATS 691
Query: 564 GNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
+D + V D+ GE GHS IT ++ + ++++VS D + W
Sbjct: 692 CSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 742
Score = 37.4 bits (85), Expect = 0.041
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 547 SINGMDITQEGVHFVTGGNDH--LVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVS 604
S++ + + +G + VTG N H V++WD E +GH + + SP ++IVS
Sbjct: 113 SLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVS 172
Query: 605 V 605
+
Sbjct: 173 M 173
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 81.6 bits (200), Expect = 2e-15
Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 11/186 (5%)
Query: 6 SPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLI-QAINTKEQNFLQGHG 64
S E + L+ V+G +GL C P H+ Y GC V+I K+Q+
Sbjct: 52 SEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTAR 111
Query: 65 NNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDL 124
++S LA S G+YI +G+ G + + +WD + + +A + HK + +AFSPN
Sbjct: 112 KSLSALAFSPDGKYIVTGE---NGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMK 168
Query: 125 YLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD-EMFMTAGNGTIR 183
++VS+G D + VW K+D + S V + S D F+T GN +R
Sbjct: 169 HIVSMGYQHDMVLNVWD-WKKDIVVASNKVSCRV-----IALSFSEDSSYFVTVGNRHVR 222
Query: 184 VWELDL 189
W L++
Sbjct: 223 FWFLEV 228
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/171 (20%), Positives = 70/171 (40%), Gaps = 9/171 (5%)
Query: 453 LEEALKEHKSSVSCIRVKRNNE-ECVTASTDGTCIIW------DLVRLRRNQMILANTLF 505
LE+ L +H SS++ I+ N + + ++ D + D + R + T
Sbjct: 572 LEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTL 631
Query: 506 QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS--GSINGMDITQEGVHFVTG 563
+ + + + DR + + +G + +GS GS+ + + G T
Sbjct: 632 YDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATS 691
Query: 564 GNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
+D + V D+ GE GHS IT ++ + ++++VS D + W
Sbjct: 692 CSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 742
Score = 37.4 bits (85), Expect = 0.041
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 547 SINGMDITQEGVHFVTGGNDH--LVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVS 604
S++ + + +G + VTG N H V++WD E +GH + + SP ++IVS
Sbjct: 113 SLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVS 172
Query: 605 V 605
+
Sbjct: 173 M 173
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 80.5 bits (197), Expect = 4e-15
Identities = 55/179 (30%), Positives = 83/179 (46%), Gaps = 11/179 (6%)
Query: 12 AELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTV-LIQAINTKEQNFLQGHGNNVSCL 70
+++ L+ V+G GL C P + YP GC V L K+ + L ++ L
Sbjct: 37 SKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITAL 96
Query: 71 AISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLG 130
A S G+Y+ +G+ G + +WD +A L HK + +AFSP+ Y+VS+G
Sbjct: 97 AFSPDGKYLVTGE---SGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVG 153
Query: 131 GPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSR-CRDEMFMTAGNGTIRVWELD 188
D V VW+ K + + + T V FS C F+TAGN I+ W LD
Sbjct: 154 YQHDMIVNVWAWKKNIVVASNKVS----SRVTAVSFSEDC--SYFVTAGNRHIKFWYLD 206
Score = 53.1 bits (126), Expect = 7e-07
Identities = 37/173 (21%), Positives = 74/173 (42%), Gaps = 10/173 (5%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW--------DLVRLRRNQMILANTL 504
L++ L EH SS++ ++ ++ + S I+ D V+ R ++ T
Sbjct: 553 LQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTT 612
Query: 505 FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS--GSINGMDITQEGVHFVT 562
+ P DR I + + G + +GS G++ + G++ T
Sbjct: 613 LYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIAT 672
Query: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
+D + ++D++ GE GHS +T ++ S ++++SVS D I W+
Sbjct: 673 SCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 725
Score = 40.0 bits (92), Expect = 0.006
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 52/201 (25%)
Query: 401 FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISG--GGEGEVRVWQIGCQTQKLEEALK 458
F P + +++N++ + +TA+A + D K +++G G VRVW + +Q E L+
Sbjct: 75 FNPRKHKQHHILNSSRKT-ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAE--LQ 131
Query: 459 EHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQII 518
EHK V+C+ + + V+ I+ ++ ++N ++ +N
Sbjct: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIV-NVWAWKKNIVVASN---------------- 174
Query: 519 TSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGE 578
+S + + +++ +FVT GN H +K W ++ +
Sbjct: 175 ------------------------KVSSRVTAVSFSEDCSYFVTAGNRH-IKFWYLDDSK 209
Query: 579 VTHVG-----VGHSGNITRIR 594
+ V +G SG + +R
Sbjct: 210 TSKVNATVPLLGRSGLLGELR 230
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 80.5 bits (197), Expect = 4e-15
Identities = 55/179 (30%), Positives = 83/179 (46%), Gaps = 11/179 (6%)
Query: 12 AELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTV-LIQAINTKEQNFLQGHGNNVSCL 70
+++ L+ V+G GL C P + YP GC V L K+ + L ++ L
Sbjct: 37 SKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITAL 96
Query: 71 AISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLG 130
A S G+Y+ +G+ G + +WD +A L HK + +AFSP+ Y+VS+G
Sbjct: 97 AFSPDGKYLVTGE---SGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVG 153
Query: 131 GPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSR-CRDEMFMTAGNGTIRVWELD 188
D V VW+ K + + + T V FS C F+TAGN I+ W LD
Sbjct: 154 YQHDMIVNVWAWKKNIVVASNKVS----SRVTAVSFSEDC--SYFVTAGNRHIKFWYLD 206
Score = 53.1 bits (126), Expect = 7e-07
Identities = 37/173 (21%), Positives = 74/173 (42%), Gaps = 10/173 (5%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW--------DLVRLRRNQMILANTL 504
L++ L EH SS++ ++ ++ + S I+ D V+ R ++ T
Sbjct: 559 LQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTT 618
Query: 505 FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS--GSINGMDITQEGVHFVT 562
+ P DR I + + G + +GS G++ + G++ T
Sbjct: 619 LYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIAT 678
Query: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
+D + ++D++ GE GHS +T ++ S ++++SVS D I W+
Sbjct: 679 SCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 731
Score = 40.0 bits (92), Expect = 0.006
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 52/201 (25%)
Query: 401 FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISG--GGEGEVRVWQIGCQTQKLEEALK 458
F P + +++N++ + +TA+A + D K +++G G VRVW + +Q E L+
Sbjct: 75 FNPRKHKQHHILNSSRKT-ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAE--LQ 131
Query: 459 EHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQII 518
EHK V+C+ + + V+ I+ ++ ++N ++ +N
Sbjct: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIV-NVWAWKKNIVVASN---------------- 174
Query: 519 TSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGE 578
+S + + +++ +FVT GN H +K W ++ +
Sbjct: 175 ------------------------KVSSRVTAVSFSEDCSYFVTAGNRH-IKFWYLDDSK 209
Query: 579 VTHVG-----VGHSGNITRIR 594
+ V +G SG + +R
Sbjct: 210 TSKVNATVPLLGRSGLLGELR 230
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 77.0 bits (188), Expect = 5e-14
Identities = 130/632 (20%), Positives = 250/632 (39%), Gaps = 68/632 (10%)
Query: 9 AQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVS 68
A L L+ V G+ GH + + ++Y + ++ + Q F +GH +++
Sbjct: 6 APSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDII 65
Query: 69 CLAISRSGEYIASGQVTFMGFKADIILWD-YKNRELLARLSLHKGKIEALAFSPNDLYLV 127
LA+ +A+GQV G + I +WD Y + + +H I LAF + LV
Sbjct: 66 SLALHPERVLVATGQV---GKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLV 122
Query: 128 SLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL 187
S+G +V VW + + +P + ++ + + ++ G I+ W L
Sbjct: 123 SVGLDSKNAVCVWDWKRGKMLSMAPG---HTDRIFDISWDLYQPNKLVSCGVKHIKFWSL 179
Query: 188 D----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVG 243
P R ++ +TG L+ I+ D+ Y G GDI + T G
Sbjct: 180 CGNALTPKRGVFG---KTGDLQTILCLACARDE--LTYSGALNGDIYVWKGINLIRTIQG 234
Query: 244 PAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQL----QG--GITSIT 297
+ G+ ++ + G G + ++ + +KPI I L QG G++ +
Sbjct: 235 ----AHAAGIFSMNACEEGFATGGRDGCIRLWDLT--FKPITVIDLRETDQGYKGLSVRS 288
Query: 298 LRGEGHQFLVGTEESHIYRVSFTD-FKETLIATCHFDAVEDIVFPFGTAELFATCA-KKD 355
+ G LVGT++S I+ + + K LI H + + T L T + +
Sbjct: 289 VCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRS 348
Query: 356 IRVWHTSSNRELLRITVPN-MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINN 414
+R+W + + R + + C ++ DG + DG + I +
Sbjct: 349 VRIWSLVDHALIARCNMEEPIRCAAVN--ADGIHLALGMKDGSFTVLRVRDMTEVVHIKD 406
Query: 415 AHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCI-RVKRNN 473
+ + + + D + G + V ++ + + +K+ E L S+S I + ++
Sbjct: 407 -RKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECL----GSLSFITHLDWSS 461
Query: 474 EECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFD 533
+ + DG LF Y + +TS + K +W +
Sbjct: 462 DSRYLQTNDGN----------------GKRLF----YRMPGGKEVTSTEEIKGVHWASWT 501
Query: 534 GTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVKVWDY---NEGEVTHVGVG 585
E+ G S IN +D G VT + ++K++ Y +G +G
Sbjct: 502 CVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIG 561
Query: 586 HSGNITRIRISPGNQYIVSV-SADGAILRWKY 616
HS ++T +R S Q+++S+ AD ++ +WK+
Sbjct: 562 HSAHVTNVRWSHDYQWVISIGGADHSVFQWKF 593
Score = 61.6 bits (148), Expect = 2e-09
Identities = 129/667 (19%), Positives = 249/667 (37%), Gaps = 117/667 (17%)
Query: 11 VAELELDAVIGFNGH-VPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSC 69
+ +L L+ + G+ G + D + +IY ++ + T Q+F Q H +++ C
Sbjct: 1368 IEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILC 1427
Query: 70 LAISRSGEYI---ASGQVTFMGFKAD-------IILWDYKNRELLARLSLHKGK-IEALA 118
L +++ ++I A+GQV G AD I +WD N++ L+ L + K + +++
Sbjct: 1428 LTVNQHPKFINIVATGQV---GDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVS 1484
Query: 119 FSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAG 178
FS L+S+G + ++ +W + I + A F D F++ G
Sbjct: 1485 FSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAE---FRPDSDTQFVSVG 1541
Query: 179 NGTIRVWELD----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNP 234
++ W L L + + T + ++ G ++ + GT +GD+
Sbjct: 1542 VKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGA---NNLTFTGTISGDVCVWKD 1598
Query: 235 RTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSG------AGLLVFCKSPGYKPIKKIQ 288
L V A + V A+ GL+V G G V + + +
Sbjct: 1599 HI-LCRIVARAHNG---PVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFR 1654
Query: 289 LQGG----ITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGT 344
L+ G RG+G + LVGT + I V + ++ H D G
Sbjct: 1655 LETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACNILVNGHVD---------GP 1704
Query: 345 AELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPE 404
AT +D +SA DG +R +
Sbjct: 1705 IWGLATHPSRDF--------------------------------FLSAAEDGTVRLWDIA 1732
Query: 405 TGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSV 464
+++ +N H + D V G GE + + + K+ ++ + ++
Sbjct: 1733 DKKMLNKVNLGHAARTVCYSPEGD--MVAIGMKNGEFIILLV--SSLKIWGKKRDRRCAI 1788
Query: 465 SCIRVKRNNEECVTASTDGTCIIWDLV---RLRRNQMI--LANTLFQCVCYHPEEFQIIT 519
IR ++ S++ + +DL L R + + + Q + ++
Sbjct: 1789 HDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVS 1848
Query: 520 SGTDRKIAY------------------WEVFDGTVIRELEGSLS-----GSINGMDITQE 556
SG ++ Y W + + E+ G S +N ++
Sbjct: 1849 SGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHS 1908
Query: 557 GVHFVTGGNDHLVKVWDY--NEGEVTHVG-VGHSGNITRIRISPGNQYIVSVSADG-AIL 612
G+ VTG + +VK++D+ E H +GHS ++T IR + G++++VS D ++
Sbjct: 1909 GISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLF 1968
Query: 613 RWKYPYT 619
WK +T
Sbjct: 1969 VWKCVHT 1975
Score = 60.1 bits (144), Expect = 6e-09
Identities = 98/419 (23%), Positives = 162/419 (38%), Gaps = 69/419 (16%)
Query: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
+ L V G+ G+ + ++Y + +I Q F GH +++ CL I
Sbjct: 677 IRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIH 736
Query: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGK----IEALAFSPNDLYLVSL 129
+Y+A+GQV G I +WD E + LS+ KG + A+ FS + L S+
Sbjct: 737 PLKDYVATGQV---GRDPSIHIWD---TETIKPLSILKGHHQYGVSAVDFSADGKRLASV 790
Query: 130 GGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTI--RVWEL 187
G D +VV+W K + + S A G +D++F+ N + ++
Sbjct: 791 GIDDSHTVVLWDWKKGEKL--SIARG-------------SKDKIFVVKMNPYVPDKLITA 835
Query: 188 DLPNRKIWPTECQTGQL--KRIVMSIGVDD---------DDSFFYLGTTTGDILKMNPRT 236
+ + K W + G + K + ++G +D + + GT+TGD+ R
Sbjct: 836 GIKHMKFW-RKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RD 892
Query: 237 KLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLV-----FCKSPGYKPIKKIQLQG 291
L A D + A+ G + G G++ F + IK+ L
Sbjct: 893 IFLVKTVKAHDGPVFSMHALE----KGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAP 948
Query: 292 GITSITLR----------GEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFP 341
G + L G GH LVGT+ I V + TL+ H +E V+
Sbjct: 949 GSKGLLLEDNPSIRAISLGHGH-ILVGTKNGEILEVDKSG-PITLLVQGH---MEGEVWG 1003
Query: 342 FGTAELFATCA----KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDG 396
T CA K +R+W S + +L + F DGK++ NDG
Sbjct: 1004 LATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDG 1062
Score = 39.3 bits (90), Expect = 0.011
Identities = 23/95 (24%), Positives = 43/95 (45%), Gaps = 4/95 (4%)
Query: 507 CVCYHPEEFQIITS--GTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGG 564
C+ HP + + T G D I W+ + L+G ++ +D + +G + G
Sbjct: 732 CLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVG 791
Query: 565 ND--HLVKVWDYNEGEVTHVGVGHSGNITRIRISP 597
D H V +WD+ +GE + G I ++++P
Sbjct: 792 IDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNP 826
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 77.0 bits (188), Expect = 5e-14
Identities = 56/261 (21%), Positives = 111/261 (42%), Gaps = 5/261 (1%)
Query: 356 IRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 415
+ +W+ + R + F G + SA D +R + P+ R + A
Sbjct: 42 LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDK-RGKFSEFKA 100
Query: 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 475
H V ++ ++D + + + + ++VW + Q+ +L H V C + +
Sbjct: 101 HTAPVRSVDFSADGQFLATASEDKSIKVWSM--YRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDG 534
V+ S D T IWD + + F V ++P I ++G+D+ + W+V
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 535 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIR 594
+++ + SG +N + G + +T +D +K+ D EG + + GH+G + +
Sbjct: 219 KLLQHYQVH-SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 595 ISPGNQYIVSVSADGAILRWK 615
S G + S AD +L W+
Sbjct: 278 FSKGGELFASGGADTQVLLWR 298
Score = 75.9 bits (185), Expect = 1e-13
Identities = 57/235 (24%), Positives = 101/235 (42%), Gaps = 9/235 (3%)
Query: 380 IDFMRDGKSIISAWNDGKIRA--FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGG 437
+D +GK + +A D + F P YV H+ VT++ + + S
Sbjct: 24 LDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV---GHKDVVTSVQFSPHGNLLASASR 80
Query: 438 EGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQ 497
+ VR+W I + K E K H + V + + + TAS D + +W + R R
Sbjct: 81 DRTVRLW-IPDKRGKFSE-FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY 138
Query: 498 MILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQE 556
+ +T + +C + P+ I++ D+ I W+ + + S+ G N +D
Sbjct: 139 SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV-GFANFVDFNPS 197
Query: 557 GVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAI 611
G + G+D VKVWD ++ HSG + I P Y+++ S+DG +
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Score = 67.4 bits (163), Expect = 4e-11
Identities = 63/298 (21%), Positives = 124/298 (41%), Gaps = 19/298 (6%)
Query: 290 QGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVF-PFGTAELF 348
+ ITS+ L G Q + ++ + +F H D V + F P G L
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LA 76
Query: 349 ATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRL 408
+ + +R+W + +DF DG+ + +A D I+ ++ R
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
Query: 409 MYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIR 468
+Y + H V + D + ++S + +++W T K + + SV
Sbjct: 137 LYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWD---TTNK--QCVNNFSDSVGFAN 190
Query: 469 VKRNNEE--CV-TASTDGTCIIWDLVRLRRNQMI----LANTLFQCVCYHPEEFQIITSG 521
N C+ +A +D T +WD +R N+++ + + C+ +HP +IT+
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWD---VRVNKLLQHYQVHSGGVNCISFHPSGNYLITAS 247
Query: 522 TDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEV 579
+D + ++ +G +I L+G +G + + ++ G F +GG D V +W N E+
Sbjct: 248 SDGTLKILDLLEGRLIYTLQGH-TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/163 (21%), Positives = 66/163 (40%), Gaps = 2/163 (1%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-VRLRRNQMILANTLFQCVCYH 511
LE K HK++++ + + N ++ TAS D ++W+ R + + + V +
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 512 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 571
P + ++ DR + W E + + + +D + +G T D +KV
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAH-TAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 572 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
W + H+ + + SP + IVS S D I W
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Score = 34.7 bits (78), Expect = 0.27
Identities = 29/131 (22%), Positives = 58/131 (44%), Gaps = 10/131 (7%)
Query: 57 QNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEA 116
+ + +GH ++ L +S +G+ +A+ + ++LW++K R HK + +
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATAS-----WDTFLMLWNFKPHARAYRYVGHKDVVTS 65
Query: 117 LAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMT 176
+ FSP+ L S D +V +W KR A + +V FS +
Sbjct: 66 VQFSPHGNLLAS--ASRDRTVRLWIPDKRGKFSEFKA---HTAPVRSVDFSADGQFLATA 120
Query: 177 AGNGTIRVWEL 187
+ + +I+VW +
Sbjct: 121 SEDKSIKVWSM 131
Score = 34.3 bits (77), Expect = 0.35
Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 11/153 (7%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L H + V C S G I S I +WD N++ + S G + F
Sbjct: 140 LYRHTHWVRCAKFSPDGRLIVS-----CSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDF 194
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGN 179
+P+ + S G D +V VW + + ++ G + F + + + +
Sbjct: 195 NPSGTCIASAG--SDQTVKVWDVRVNKLL---QHYQVHSGGVNCISFHPSGNYLITASSD 249
Query: 180 GTIRVWELDLPNRKIWPTECQTGQLKRIVMSIG 212
GT+++ +L L R I+ + TG + + S G
Sbjct: 250 GTLKILDL-LEGRLIYTLQGHTGPVFTVSFSKG 281
Score = 32.7 bits (73), Expect = 1.0
Identities = 28/112 (25%), Positives = 50/112 (44%), Gaps = 12/112 (10%)
Query: 75 SGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDD 134
SG IAS G + +WD + +LL +H G + ++F P+ YL++ D
Sbjct: 197 SGTCIASA-----GSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT--ASSD 249
Query: 135 GSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGT-IRVW 185
G++ + + + I + G V FS+ E+F + G T + +W
Sbjct: 250 GTLKILDLLEGRLIYTLQG---HTGPVFTVSFSK-GGELFASGGADTQVLLW 297
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 74.7 bits (182), Expect = 2e-13
Identities = 133/639 (20%), Positives = 247/639 (38%), Gaps = 69/639 (10%)
Query: 1 MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFL 60
M ++ +P Q L L+ V G+ GH + + ++Y + ++ Q F
Sbjct: 1 MADRTAPRCQ---LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFF 57
Query: 61 QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAF 119
GH +++ LA+ +A+GQV G + I +WD N + ++ L +H + LAF
Sbjct: 58 LGHNDDIISLALHPDKTLVATGQV---GKEPYICIWDSYNVQTVSLLKDVHTHGVACLAF 114
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGN 179
+ L S+G +V +W K + + + ++ + + ++ G
Sbjct: 115 DSDGQRLASVGLDAKNTVCIWDWRKGKLLASATG---HSDRIFDISWDPYQPNRVVSCGV 171
Query: 180 GTIRVWELD----LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPR 235
I+ W L R I+ +TG L+ I+ +D Y G GDI
Sbjct: 172 KHIKFWTLCGNALTAKRGIFG---KTGDLQTILCLACAKED--ITYSGALNGDIYVW--- 223
Query: 236 TKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQL---QGG 292
K L V + S G+ ++ + G G + ++ +KPI KI L + G
Sbjct: 224 -KGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLW--DTDFKPITKIDLRETEQG 280
Query: 293 ITSITLRG---EGHQFLVGTEESHIYRVSFTD-FKETLIATCHFDAVEDIVFPFGTAELF 348
+++R + + L GT++S I+ V + K LI H + + L
Sbjct: 281 YKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLA 340
Query: 349 ATCA-KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGR 407
T + + +R+W + + + R + + F DG + DG
Sbjct: 341 VTGSDDRSVRLWSLADHALIARCNMEE-AVRSVAFSPDGSQLALGMKDGSFIVLRVRDMT 399
Query: 408 LMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCI 467
+ I + + + + + D + G +G V V+ + + +K+ E K S+S I
Sbjct: 400 EVVHIKDRKEV-IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSK----SLSFI 454
Query: 468 RVKRNNEECVTASTDGTCIIWDL-VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKI 526
T I W L + + LF Y + +TS + K
Sbjct: 455 ----------------THIDWSLDSKYLQTNDGAGERLF----YRMPSGKPLTSKEEIKG 494
Query: 527 AYWEVFDGTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVKVWDY---NEGE 578
W + E+ G + IN +D V+G + LVK++ + G
Sbjct: 495 IPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGA 554
Query: 579 VTHVGVGHSGNITRIRISPGNQYIVSV-SADGAILRWKY 616
VGHS ++T +R S Q+++S AD ++ +W++
Sbjct: 555 KFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRF 593
Score = 73.9 bits (180), Expect = 4e-13
Identities = 141/648 (21%), Positives = 246/648 (37%), Gaps = 105/648 (16%)
Query: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
L+L + G+ G+ + ++Y + ++ Q GH +++ L I
Sbjct: 677 LKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIH 736
Query: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAFSPNDLYLVSLGGP 132
+Y+A+GQV G A I +WD + + L+ L H+ + AL FS + LVS+G
Sbjct: 737 PVKDYVATGQV---GRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLD 793
Query: 133 DDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD---EMFMTAGNGTIRVWEL-- 187
D S+V W K + I + G+ + +C + +T G I+ W+
Sbjct: 794 DFHSIVFWDWKKGEKIATTR------GHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAG 847
Query: 188 -DLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLT---DVG 243
+++ T G+L+ +M + + + G TGDI L T G
Sbjct: 848 GGFTSKR--GTFGSVGKLE-TMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDG 904
Query: 244 PAKDKFSLGVSAI----------------RCLKMGGL----LVGSGAGLLVFCKSPGYKP 283
P ++L + RCLK + L S GLL
Sbjct: 905 PVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLL---------- 954
Query: 284 IKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFG 343
++ I +ITL G GH LVGT+ I + + TL+ H +E V+
Sbjct: 955 ---LEDNPSIRAITL-GHGH-ILVGTKNGEILEIDKSG-PMTLLVQGH---MEGEVWGLA 1005
Query: 344 TAELFATCA----KKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIR 399
L CA K +R+W S+ +L + F DGK++ NDG
Sbjct: 1006 AHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFL 1065
Query: 400 AFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKE 459
+T M ++ + ++ I + D + + A+
Sbjct: 1066 VVNADTVEDMVSFHHRKEM-ISDIKFSKDTGKYL----------------------AVAS 1102
Query: 460 HKSSVSCIRVKRNNEE--CVTASTDGTCIIWDLVRLRRNQMILANT--LFQCVCYHPEEF 515
H + V V + C AS+ T I WD R +++ N+ Q P
Sbjct: 1103 HDNFVDIYNVLTSKRVGICKGASSYITHIDWD----SRGKLLQVNSGAREQLFFEAPRGK 1158
Query: 516 QIITSGTDRKIAYWEVFDGTVIRELEG-----SLSGSINGMDITQEGVHFVTGGNDHLVK 570
+ I ++ + W+ + + EG S +N +T++ TG + VK
Sbjct: 1159 RHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVK 1218
Query: 571 VWDYN-EGEVTHVG--VGHSGNITRIRISPGNQYIVSV-SADGAILRW 614
++ Y +G+ VGHS ++T +R + +++V AD A++ W
Sbjct: 1219 LFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
Score = 69.7 bits (169), Expect = 8e-12
Identities = 134/650 (20%), Positives = 240/650 (36%), Gaps = 98/650 (15%)
Query: 11 VAELELDAVIGFNGH-VPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSC 69
V EL LD V G+ G L D +I+ ++Q ++T Q+F H +++ C
Sbjct: 1360 VEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILC 1419
Query: 70 LAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARL-SLHKGKIEALAFSPNDLYLVS 128
L +++ +Y + +G I +WD + L+ L H + + FS LVS
Sbjct: 1420 LTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVS 1479
Query: 129 LGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL- 187
+G + ++ VW + + + G ++ V F D F++ G ++ W L
Sbjct: 1480 VGVDPEHTITVWRWQEGAKVA---SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA 1536
Query: 188 --DLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNP----RTKLLTD 241
L +K G K M ++ + G GD+ R
Sbjct: 1537 GSALLYKK--GVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAH 1594
Query: 242 VGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGG----ITSIT 297
GP ++ + + GG + G V K + QL+ G
Sbjct: 1595 TGPVFTMYTTLRDGL--IVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSV 1652
Query: 298 LRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIR 357
RG+G + LVGT++ I V + ++ H + G AT KD+
Sbjct: 1653 CRGKG-KILVGTKDGEIIEVGEKNAASNILIDGHME---------GEIWGLATHPSKDL- 1701
Query: 358 VWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHR 417
ISA NDG R + +L+ ++ H
Sbjct: 1702 -------------------------------FISASNDGTARIWDLADKKLLNKVSLGH- 1729
Query: 418 IGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECV 477
A + D + V G GE + + + K+ ++ KS++ IR+ +N
Sbjct: 1730 -AARCAAYSPDGEMVAIGMKNGEFVILLV--NSLKVWGKKRDRKSAIQDIRISPDNRFLA 1786
Query: 478 TASTDGTCIIWDLV------RLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKI----A 527
S++ T +DL R+ + I + + + Q+ T R++
Sbjct: 1787 VGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPL 1846
Query: 528 YWEVFDGTVIRELEGSLSGSINGMD------------------ITQEGVHFVTGGNDHLV 569
+V + VI ++ + S+ G + +T G++ VTG + LV
Sbjct: 1847 GKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLV 1906
Query: 570 KVWDY--NEGEVTHVG-VGHSGNITRIRISPGNQYIVSVSADG-AILRWK 615
K++D+ E H GHS ++T IR S ++Y+VS D ++ W+
Sbjct: 1907 KLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1956
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 73.6 bits (179), Expect = 5e-13
Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 11/292 (3%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H AV + F L ++ A K I++W + I+ + + + D ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
SA +D ++ + +G+ + + H V ++SG + VR+W + +T
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KT 160
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 508
K + L H VS + R+ V++S DG C IWD + + ++ N V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 565
+ P I+ + D + W+ G ++ G + +T G V+G
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 279
Query: 566 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA--DGAILRWK 615
D+LV +W+ E+ GH+ + P I S + D I WK
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 69.3 bits (168), Expect = 1e-11
Identities = 41/203 (20%), Positives = 94/203 (46%), Gaps = 5/203 (2%)
Query: 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 475
H V+++ + + + + S + +++W G K E+ + HK +S + ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 534
V+AS D T IWD+ + + + ++ + C ++P+ I++ D + W+V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 535 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 593
++ L S ++ + ++G V+ D L ++WD G+ + ++ +
Sbjct: 162 KCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 594 RISPGNQYIVSVSADGAILRWKY 616
+ SP +YI++ + D + W Y
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDY 243
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 511
L+ L H +VS ++ N E ++S D IW + + I + L V +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 512 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 571
+ ++++ D+ + W+V G ++ L+G S + + + V+G D V++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 572 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
WD G+ HS ++ + + IVS S DG W
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 34.3 bits (77), Expect = 0.35
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 24/135 (17%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L GH VS + S +GE++AS + I +W + + +S HK I +A+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKL-----IKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAG-------LNVGNATNVIFSRCRDE 172
S + LVS DD ++ +W ++ C G N +N+I S DE
Sbjct: 96 SSDSNLLVS--ASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 173 MFMTAGNGTIRVWEL 187
++R+W++
Sbjct: 152 --------SVRIWDV 158
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 73.6 bits (179), Expect = 5e-13
Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 11/292 (3%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H AV + F L ++ A K I++W + I+ + + + D ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
SA +D ++ + +G+ + + H V ++SG + VR+W + +T
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KT 160
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 508
K + L H VS + R+ V++S DG C IWD + + ++ N V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 565
+ P I+ + D + W+ G ++ G + +T G V+G
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 279
Query: 566 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA--DGAILRWK 615
D+LV +W+ E+ GH+ + P I S + D I WK
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 69.3 bits (168), Expect = 1e-11
Identities = 41/203 (20%), Positives = 94/203 (46%), Gaps = 5/203 (2%)
Query: 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 475
H V+++ + + + + S + +++W G K E+ + HK +S + ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 534
V+AS D T IWD+ + + + ++ + C ++P+ I++ D + W+V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 535 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 593
++ L S ++ + ++G V+ D L ++WD G+ + ++ +
Sbjct: 162 KCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 594 RISPGNQYIVSVSADGAILRWKY 616
+ SP +YI++ + D + W Y
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDY 243
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 511
L+ L H +VS ++ N E ++S D IW + + I + L V +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 512 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 571
+ ++++ D+ + W+V G ++ L+G S + + + V+G D V++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 572 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
WD G+ HS ++ + + IVS S DG W
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 34.3 bits (77), Expect = 0.35
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 24/135 (17%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L GH VS + S +GE++AS + I +W + + +S HK I +A+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKL-----IKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAG-------LNVGNATNVIFSRCRDE 172
S + LVS DD ++ +W ++ C G N +N+I S DE
Sbjct: 96 SSDSNLLVS--ASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 173 MFMTAGNGTIRVWEL 187
++R+W++
Sbjct: 152 --------SVRIWDV 158
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 69.7 bits (169), Expect = 8e-12
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 16/203 (7%)
Query: 419 GVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVT 478
G+T+I S +++ + R+W + +L L H V + +N V+
Sbjct: 368 GITSIEFDSAGSYLLAASNDFASRIWTV--DDYRLRHTLTGHSGKVLSAKFLLDNARIVS 425
Query: 479 ASTDGTCIIWDLVRLRRNQMILANTLF---QCVCYHPEEFQIITSGTDRKIAYWEVFDGT 535
S D T +WDL + T+F C E +++ D+KI +W++ +
Sbjct: 426 GSHDRTLKLWDL-----RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 480
Query: 536 VIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHV----GVGHSGNIT 591
++RE+E L G I +D+ E ++ D L+KV D + G + T
Sbjct: 481 IVREME--LLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
Query: 592 RIRISPGNQYIVSVSADGAILRW 614
R+ SP Y+ + SA+G++ W
Sbjct: 539 RVVFSPDGSYVAAGSAEGSLYIW 561
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 508 VCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGG 564
V + P + T G DR++ WEVF E +GSLSGS I ++ G + +
Sbjct: 328 VQFSPGSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAAS 385
Query: 565 NDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
ND ++W ++ + H GHSG + + N IVS S D + W
Sbjct: 386 NDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Score = 38.1 bits (87), Expect = 0.024
Identities = 62/322 (19%), Positives = 115/322 (35%), Gaps = 50/322 (15%)
Query: 289 LQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDA----VEDIVFPFGT 344
L IT+I R F V + + S + + A C FDA V + F G+
Sbjct: 275 LLDSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGS 334
Query: 345 AELFATCAKKDIRVWHTSSNRELLR--ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFA 402
L + +++W + + ++ N I+F G +++A ND R +
Sbjct: 335 RLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWT 394
Query: 403 PETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQ----------------- 445
+ RL + + H V + D R++SG + +++W
Sbjct: 395 VDDYRLRHTLTG-HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCN 453
Query: 446 -IGCQTQ----------------KLEEALKEHK--SSVSCIRVKRNNEECVTASTDGTCI 486
I C Q + E ++E + ++ + + E ++ S D
Sbjct: 454 DIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLK 513
Query: 487 IWDLVRLRRNQMILANTLFQC------VCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 540
+ DL R + + F+C V + P+ + + + W V G V + L
Sbjct: 514 VIDL-RTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVL 572
Query: 541 EGSLSGSINGMDITQEGVHFVT 562
S SIN + + G H V+
Sbjct: 573 SKQHSSSINAVAWSPSGSHVVS 594
Score = 30.8 bits (68), Expect = 3.9
Identities = 19/79 (24%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 110 HKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRC 169
H G++ A+ FSP L + G D V +W + +G N G T++ F
Sbjct: 321 HDGEVNAVQFSPGSRLLAT--GGMDRRVKLWEVFGEKCEFKGSLSGSNAG-ITSIEFDSA 377
Query: 170 RDEMFMTAGNGTIRVWELD 188
+ + + R+W +D
Sbjct: 378 GSYLLAASNDFASRIWTVD 396
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 69.7 bits (169), Expect = 8e-12
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 16/203 (7%)
Query: 419 GVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVT 478
G+T+I S +++ + R+W + +L L H V + +N V+
Sbjct: 349 GITSIEFDSAGSYLLAASNDFASRIWTV--DDYRLRHTLTGHSGKVLSAKFLLDNARIVS 406
Query: 479 ASTDGTCIIWDLVRLRRNQMILANTLF---QCVCYHPEEFQIITSGTDRKIAYWEVFDGT 535
S D T +WDL + T+F C E +++ D+KI +W++ +
Sbjct: 407 GSHDRTLKLWDL-----RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 461
Query: 536 VIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHV----GVGHSGNIT 591
++RE+E L G I +D+ E ++ D L+KV D + G + T
Sbjct: 462 IVREME--LLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 519
Query: 592 RIRISPGNQYIVSVSADGAILRW 614
R+ SP Y+ + SA+G++ W
Sbjct: 520 RVVFSPDGSYVAAGSAEGSLYIW 542
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 508 VCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGG 564
V + P + T G DR++ WEVF E +GSLSGS I ++ G + +
Sbjct: 309 VQFSPGSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAAS 366
Query: 565 NDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
ND ++W ++ + H GHSG + + N IVS S D + W
Sbjct: 367 NDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Score = 37.4 bits (85), Expect = 0.041
Identities = 46/229 (20%), Positives = 85/229 (37%), Gaps = 16/229 (6%)
Query: 342 FGTAELFATCAKKDI--RVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIR 399
F +A + A D R+W R +T + F+ D I+S +D ++
Sbjct: 355 FDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLK 414
Query: 400 AFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKE 459
+ + + + I T C V+SG + ++R W I ++ E L
Sbjct: 415 LWDLRSKVCIKTVFAGS--SCNDIVCTEQC--VMSGHFDKKIRFWDIRSESIVREMELL- 469
Query: 460 HKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC------VCYHPE 513
++ + + E ++ S D + DL R + + F+C V + P+
Sbjct: 470 --GKITALDLNPERTELLSCSRDDLLKVIDL-RTNAIKQTFSAPGFKCGSDWTRVVFSPD 526
Query: 514 EFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
+ + + W V G V + L S SIN + + G H V+
Sbjct: 527 GSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 575
Score = 30.8 bits (68), Expect = 3.9
Identities = 19/79 (24%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 110 HKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRC 169
H G++ A+ FSP L + G D V +W + +G N G T++ F
Sbjct: 302 HDGEVNAVQFSPGSRLLAT--GGMDRRVKLWEVFGEKCEFKGSLSGSNAG-ITSIEFDSA 358
Query: 170 RDEMFMTAGNGTIRVWELD 188
+ + + R+W +D
Sbjct: 359 GSYLLAASNDFASRIWTVD 377
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 68.9 bits (167), Expect = 1e-11
Identities = 40/185 (21%), Positives = 74/185 (40%), Gaps = 14/185 (7%)
Query: 449 QTQKLEEALKEH-----KSSVSCIRVKRNNEECVTASTDGTCIIW---------DLVRLR 494
+ +K L H KS V C R + + VT S DG +W DL
Sbjct: 197 EEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQA 256
Query: 495 RNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDIT 554
++ ++ + C+C+ + + T D KI W++ G +R E + S + + +
Sbjct: 257 QDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFS 316
Query: 555 QEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
++ ++ D +++ G+ GHS + + YI+S S+DG + W
Sbjct: 317 KDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Query: 615 KYPYT 619
T
Sbjct: 377 NMKTT 381
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 25/250 (10%)
Query: 382 FMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEV 441
F RD + + + DGKI+ + ++G+ + AH GVT ++ + D +++S + +
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 442 RVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQM--- 498
R+ G ++ K + + H S V+ ++ ++AS+DGT IW++ +
Sbjct: 332 RIH--GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 389
Query: 499 --------ILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSING 550
I N++ + +PE F + I + G ++R SG G
Sbjct: 390 LGSTAGTDITVNSVI-LLPKNPEHFVVCNRSNTVVIMNMQ---GQIVRSFS---SGKREG 442
Query: 551 MD-----ITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSV 605
D ++ G G D ++ + G++ H ++ I P I +
Sbjct: 443 GDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATY 502
Query: 606 SADGAILRWK 615
S DG + WK
Sbjct: 503 SEDGLLKLWK 512
Score = 32.7 bits (73), Expect = 1.0
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 12/109 (11%)
Query: 89 FKADIILWDYKNRELLARLSLH-----KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIA 143
F+ + D + + +LS H K +E FSP+ YLV+ G DG + VW+
Sbjct: 187 FRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVT--GSVDGFIEVWNFT 244
Query: 144 ----KRDAICGSPAAGLNVGNAT-NVIFSRCRDEMFMTAGNGTIRVWEL 187
++D + + + +A + FSR + + A +G I+VW++
Sbjct: 245 TGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKI 293
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 386 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 443
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 327
Query: 444 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 503
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 328 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 383
Query: 504 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 384 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 438
Query: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 439 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 488
Score = 60.5 bits (145), Expect = 5e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 383 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 442
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 311 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 366
Query: 443 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 502
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 367 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 422
Query: 503 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 423 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 478
Query: 563 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 614
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 479 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 531
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 385 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 444
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 448
Query: 445 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 449 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 504
Query: 505 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 551
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 505 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 553
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 386 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 443
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 445
Query: 444 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 503
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 446 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 501
Query: 504 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 502 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 556
Query: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 557 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 606
Score = 60.5 bits (145), Expect = 5e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 383 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 442
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 429 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 484
Query: 443 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 502
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 485 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540
Query: 503 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 541 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 596
Query: 563 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 614
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 597 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 649
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 385 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 444
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 566
Query: 445 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 567 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 622
Query: 505 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 551
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 623 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 671
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 386 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 443
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 365
Query: 444 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 503
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 366 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 421
Query: 504 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 422 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 476
Query: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 477 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 526
Score = 60.5 bits (145), Expect = 5e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 383 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 442
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 349 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 404
Query: 443 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 502
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 405 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 460
Query: 503 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 562
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 461 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 516
Query: 563 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 614
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 517 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 569
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 385 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 444
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 486
Query: 445 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 487 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 542
Query: 505 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 551
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 543 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 591
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 8/191 (4%)
Query: 427 SDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCI 486
+D ++S + +R W +G T + + H V + + + + S D T
Sbjct: 352 ADSSGLLSCSEDMSIRYWDLGSFTNTV--LYQGHAYPVWDLDISPYSLYFASGSHDRTAR 409
Query: 487 IWDLVR---LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGS 543
+W R LR LA+ CV +HP + T TD+ + W G +R G
Sbjct: 410 LWSFDRTYPLRIYAGHLADV--DCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGH 467
Query: 544 LSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIV 603
G + + + G + + G D +K+WD G + GH+ NIT + SP + I
Sbjct: 468 -RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526
Query: 604 SVSADGAILRW 614
S S D ++ W
Sbjct: 527 SASMDNSVRVW 537
Score = 46.6 bits (109), Expect = 7e-05
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 14/128 (10%)
Query: 62 GHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSP 121
GH +V C+ + Y+A+G + LW + + + H+G + +LAFSP
Sbjct: 424 GHLADVDCVKFHPNSNYLATGSTD-----KTVRLWSAQQGNSVRLFTGHRGPVLSLAFSP 478
Query: 122 NDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGL--NVGNATNVIFSRCRDEMFMTAGN 179
N YL S G +D + +W +A G+ L + N T++ FS + + +
Sbjct: 479 NGKYLASAG--EDQRLKLWDLAS-----GTLYKELRGHTDNITSLTFSPDSGLIASASMD 531
Query: 180 GTIRVWEL 187
++RVW++
Sbjct: 532 NSVRVWDI 539
Score = 36.6 bits (83), Expect = 0.071
Identities = 26/116 (22%), Positives = 46/116 (39%), Gaps = 1/116 (0%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H V+ + F + L K +R+W + T + F +GK +
Sbjct: 425 HLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLA 484
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 446
SA D +++ + +G L Y H +T++ + D + S + VRVW I
Sbjct: 485 SAGEDQRLKLWDLASGTL-YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 35.4 bits (80), Expect = 0.16
Identities = 21/111 (18%), Positives = 53/111 (47%), Gaps = 3/111 (2%)
Query: 380 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 439
+ F + + + D +R ++ + G + + HR V ++A + + K + S G +
Sbjct: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG-HRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 440 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL 490
+++W + T L + L+ H +++ + ++ +AS D + +WD+
Sbjct: 491 RLKLWDLASGT--LYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 32.3 bits (72), Expect = 1.3
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 7/88 (7%)
Query: 61 QGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFS 120
QGH V L IS Y ASG LW + L + H ++ + F
Sbjct: 381 QGHAYPVWDLDISPYSLYFASGS-----HDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
Query: 121 PNDLYLVSLGGPDDGSVVVWSIAKRDAI 148
PN YL + G D +V +WS + +++
Sbjct: 436 PNSNYLAT--GSTDKTVRLWSAQQGNSV 461
Score = 30.4 bits (67), Expect = 5.1
Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 25/155 (16%)
Query: 473 NEECVTASTDGTCI-IWDL----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA 527
+ + + A D +CI +W L ++ +Q+ ++ C E+ + +GT+ KI
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKIL 338
Query: 528 YWE---VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGV 584
V+ + + G LS S D ++ WD T +
Sbjct: 339 RGHCGPVYSTRFLADSSGLLSCS-----------------EDMSIRYWDLGSFTNTVLYQ 381
Query: 585 GHSGNITRIRISPGNQYIVSVSADGAILRWKYPYT 619
GH+ + + ISP + Y S S D W + T
Sbjct: 382 GHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRT 416
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/283 (20%), Positives = 112/283 (39%), Gaps = 9/283 (3%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H +AV + F L ++ A + I +W + + N+ + + D ++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
SA +D ++ + +G+ + + H V +ISG + V++W++ +T
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKG-HSNYVFCCNFNPPSNLIISGSFDETVKIWEV--KT 156
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 508
K + L H VS + + V+ S DG C IWD + + ++ N V
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 565
+ P I+T+ D + W+ G ++ G + +T G V+G
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 275
Query: 566 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 608
D+LV +W+ E+ GH+ + P I S + +
Sbjct: 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 5/203 (2%)
Query: 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 475
H V+++ + + + + S + + +W G K E+ L H +S + ++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIW--GAYDGKYEKTLYGHNLEISDVAWSSDSSR 97
Query: 476 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 534
V+AS D T +WD+ + + + ++ + C ++P II+ D + WEV G
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 535 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 593
++ L S ++ + G V+G D L ++WD G+ V ++ +
Sbjct: 158 KCLKTLSAH-SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 594 RISPGNQYIVSVSADGAILRWKY 616
+ SP +YI++ + D + W Y
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDY 239
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/239 (20%), Positives = 105/239 (43%), Gaps = 7/239 (2%)
Query: 380 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 439
+ F +G+ + S+ D I + G+ + H + ++ +A +SD R++S +
Sbjct: 47 VKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG-HNLEISDVAWSSDSSRLVSASDDK 105
Query: 440 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 499
+++W + ++ K + LK H + V C + ++ S D T IW++ + + +
Sbjct: 106 TLKLWDV--RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 500 LANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGV 558
A++ V ++ I++ D W+ G ++ L + ++ + + G
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223
Query: 559 HFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRIS---PGNQYIVSVSADGAILRW 614
+ +T D+ +K+WDY+ G GH I + G ++IVS S D + W
Sbjct: 224 YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
Score = 56.2 bits (134), Expect = 9e-08
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 2/163 (1%)
Query: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 511
L+ L H +VS ++ N E ++S D IIW + + + + L V +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 512 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 571
+ +++++ D+ + W+V G ++ L+G S + + ++G D VK+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH-SNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 572 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
W+ G+ HS ++ + + IVS S DG W
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 38.9 bits (89), Expect = 0.014
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L+GH N V C + I SG F + +W+ K + L LS H + A+ F
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGS-----FDETVKIWEVKTGKCLKTLSAHSDPVSAVHF 175
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIA 143
+ + +VS G DG +W A
Sbjct: 176 NCSGSLIVS--GSYDGLCRIWDAA 197
Score = 36.6 bits (83), Expect = 0.071
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 24/135 (17%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L GH VS + S +GE++AS + II+W + + L H +I +A+
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRL-----IIIWGAYDGKYEKTLYGHNLEISDVAW 91
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAG-------LNVGNATNVIFSRCRDE 172
S + LVS DD ++ +W + R C G N +N+I S DE
Sbjct: 92 SSDSSRLVS--ASDDKTLKLWDV--RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDE 147
Query: 173 MFMTAGNGTIRVWEL 187
T+++WE+
Sbjct: 148 --------TVKIWEV 154
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/202 (22%), Positives = 87/202 (43%), Gaps = 5/202 (2%)
Query: 415 AHRIGVTAIATTSDCKRVISGGGEG-EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 473
AH V+++ R+++ GG+ V +W I + +L H S V +R+
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLNTPE 75
Query: 474 EECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWEVF 532
E V S G+ +WDL + + ++ + C + +HP + + D I W++
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 533 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 592
+ G S ++ + + +G + +DH VK+WD G++ GH+G +
Sbjct: 136 RKGCVFRYRGH-SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 593 IRISPGNQYIVSVSADGAILRW 614
+ P + S S+D I W
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFW 216
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/244 (20%), Positives = 100/244 (40%), Gaps = 14/244 (5%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRV--WHTSSNRELLRITVPNMTCHGIDFMRDGKS 388
H V +V + L AT D RV W + ++ +T + +
Sbjct: 19 HASNVSSLVLGKASGRLLAT-GGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 389 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI-- 446
I++ G IR + E +++ + H+ + ++ + V SG + +++W I
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMG-HKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 447 -GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-L 504
GC + + H +V C+R + + +A+ D T +WDL + +T
Sbjct: 137 KGCVFR-----YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 505 FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGG 564
V +HP E+ + + +DR I +W++ V+ +EG G + + +G +G
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGE-PGPVRSVLFNPDGCCLYSGC 250
Query: 565 NDHL 568
D L
Sbjct: 251 QDSL 254
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/131 (28%), Positives = 58/131 (44%), Gaps = 14/131 (10%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L GH N+ L GE++ASG +I LWD + + + R H + L F
Sbjct: 101 LMGHKANICSLDFHPYGEFVASGSQD-----TNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGN 179
SP+ +L S DD +V +W + + P + G V F +E + +G+
Sbjct: 156 SPDGKWLAS--AADDHTVKLWDLTAGKMMSEFPG---HTGPVNVVEFH--PNEYLLASGS 208
Query: 180 G--TIRVWELD 188
TIR W+L+
Sbjct: 209 SDRTIRFWDLE 219
Score = 36.6 bits (83), Expect = 0.071
Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 7/89 (7%)
Query: 60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAF 119
L GH + V + ++ E I +G + I +WD + ++L L HK I +L F
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQS-----GSIRVWDLEAAKILRTLMGHKANICSLDF 113
Query: 120 SPNDLYLVSLGGPDDGSVVVWSIAKRDAI 148
P ++ S G D ++ +W I ++ +
Sbjct: 114 HPYGEFVAS--GSQDTNIKLWDIRRKGCV 140
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/203 (18%), Positives = 72/203 (35%), Gaps = 4/203 (1%)
Query: 293 ITSITL-RGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATC 351
++S+ L + G G ++ + S + T H VE + + A
Sbjct: 23 VSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS 82
Query: 352 AKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYV 411
IRVW + + L + +DF G+ + S D I+ + ++
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 412 INNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKR 471
H V + + D K + S + V++W + K+ H V+ +
Sbjct: 143 Y-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL--TAGKMMSEFPGHTGPVNVVEFHP 199
Query: 472 NNEECVTASTDGTCIIWDLVRLR 494
N + S+D T WDL + +
Sbjct: 200 NEYLLASGSSDRTIRFWDLEKFQ 222
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 68.2 bits (165), Expect = 2e-11
Identities = 47/190 (24%), Positives = 88/190 (46%), Gaps = 4/190 (2%)
Query: 427 SDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCI 486
SD ++++GG + V V+ ++++ LK H V+ + + + +AS D T
Sbjct: 232 SDTNKILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 289
Query: 487 IWDLVRLRRNQMILAN-TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS 545
IW + Q++ A+ + + H +++S D+ A+ ++ G V+ ++ S
Sbjct: 290 IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 349
Query: 546 G-SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVS 604
G S+ +G+ F TG D +K+WD E GHSG IT I S Y+ +
Sbjct: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
Query: 605 VSADGAILRW 614
+ D ++ W
Sbjct: 410 AADDSSVKLW 419
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 7/81 (8%)
Query: 64 GNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPND 123
G +++C G +G + + I +WD K R +A H G I ++AFS N
Sbjct: 350 GCSLTCAQFHPDGLIFGTGTMD-----SQIKIWDLKERTNVANFPGHSGPITSIAFSENG 404
Query: 124 LYLVSLGGPDDGSVVVWSIAK 144
YL + DD SV +W + K
Sbjct: 405 YYLAT--AADDSSVKLWDLRK 423
Score = 41.2 bits (95), Expect = 0.003
Identities = 54/282 (19%), Positives = 108/282 (38%), Gaps = 24/282 (8%)
Query: 341 PFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRA 400
P T ++ A K++ V+ SS + L + + F + SA D IR
Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
Query: 401 FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKE 459
++ + V+ AH VT ++ + ++S + + W QT ++ + +
Sbjct: 291 WSVPNASCVQVVR-AHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTD 346
Query: 460 HKS--SVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-----FQCVCYHP 512
S S++C + + T + D IWDL + + +AN + +
Sbjct: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL----KERTNVANFPGHSGPITSIAFSE 402
Query: 513 EEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND---HLV 569
+ + T+ D + W++ + L+ + + + Q G + GG D ++
Sbjct: 403 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYIC 462
Query: 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAI 611
K W E+ H HSG T + ++I S D ++
Sbjct: 463 KQWT----EILHF-TEHSGLTTGVAFGHHAKFIASTGMDRSL 499
Score = 36.2 bits (82), Expect = 0.092
Identities = 18/60 (30%), Positives = 27/60 (45%)
Query: 561 VTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 620
+TGG D V V+D + ++ GH+ +T + P + S S D I W P S
Sbjct: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
Score = 34.7 bits (78), Expect = 0.27
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 99 KNRELLARLSLHKGKIE---ALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAG 155
K R++ + + LH I AL P+D + GG D +VVV+ + +
Sbjct: 206 KYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADK-NVVVFDKSSEQILATLKG-- 262
Query: 156 LNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL 187
+ T+V+F +D +F + + TIR+W +
Sbjct: 263 -HTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293
Score = 32.0 bits (71), Expect = 1.7
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 8/81 (9%)
Query: 54 TKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKG- 112
T NF GH ++ +A S +G Y+A+ + + LWD + + L L
Sbjct: 383 TNVANF-PGHSGPITSIAFSENGYYLATA-----ADDSSVKLWDLRKLKNFKTLQLDNNF 436
Query: 113 KIEALAFSPNDLYLVSLGGPD 133
++++L F + YL +LGG D
Sbjct: 437 EVKSLIFDQSGTYL-ALGGTD 456
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 67.8 bits (164), Expect = 3e-11
Identities = 65/249 (26%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 296 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 353
+ L+ + + G+ +S ++ V+ + TLI C +AV + F G + TC+K
Sbjct: 311 LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVLHLRFNNG---MMVTCSK 365
Query: 354 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 409
+ I VW +S + L R+ V + + +DF D K I+SA D I+ + T +
Sbjct: 366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFV 423
Query: 410 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 469
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 424 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 478
Query: 470 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 521
+N+ V+ + DG +WDLV + + + H +EFQI++S
Sbjct: 479 --DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 536
Query: 522 TDRKIAYWE 530
D I W+
Sbjct: 537 HDDTILIWD 545
Score = 62.8 bits (151), Expect = 9e-10
Identities = 67/254 (26%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 367 LLRITVPNMTCHGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 425
L RI + T G+ ++ D + I+S D I+ + T ++ H V +
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQY 315
Query: 426 TSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTC 485
D + +I+G + VRVW + T ++ L H +V + ++ NN VT S D +
Sbjct: 316 --DERVIITGSSDSTVRVWDVN--TGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSI 369
Query: 486 IIWDL-----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 540
+WD+ + LRR +++ + V +++ + SG DR I W +R L
Sbjct: 370 AVWDMASPTDITLRR--VLVGHRAAVNVVDFDDKYIVSASG-DRTIKVWNTSTCEFVRTL 426
Query: 541 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 600
G G I + V V+G +D+ +++WD G V GH + IR N+
Sbjct: 427 NGHKRG-IACLQYRDRLV--VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NK 481
Query: 601 YIVSVSADGAILRW 614
IVS + DG I W
Sbjct: 482 RIVSGAYDGKIKVW 495
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 444 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 503
W+ G + + E V C++ ++++ V+ D T IWD L +++ +T
Sbjct: 250 WRCGRHSLQRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 307
Query: 504 LFQCVCYHPEEFQIITSGTDRKIAYWEVFDG----TVIRELEGSLSGSI-NGMDITQEGV 558
+C +E IIT +D + W+V G T+I E L NGM
Sbjct: 308 -GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM------- 359
Query: 559 HFVTGGNDHLVKVWDY---NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
VT D + VWD + + V VGH + + ++YIVS S D I W
Sbjct: 360 -MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 415
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 18/180 (10%)
Query: 320 TDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHG 379
TD + H AV V F + + + I+VW+TS+ E +R N G
Sbjct: 378 TDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNTSTC-EFVRTL--NGHKRG 432
Query: 380 IDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGE 438
I ++ + ++S +D IR + E G + V+ H V I D KR++SG +
Sbjct: 433 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGAYD 489
Query: 439 GEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLV 491
G+++VW + A L EH V R++ + + V++S D T +IWD +
Sbjct: 490 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 547
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 67.8 bits (164), Expect = 3e-11
Identities = 65/249 (26%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 296 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 353
+ L+ + + G+ +S ++ V+ + TLI C +AV + F G + TC+K
Sbjct: 347 LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVLHLRFNNG---MMVTCSK 401
Query: 354 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 409
+ I VW +S + L R+ V + + +DF D K I+SA D I+ + T +
Sbjct: 402 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFV 459
Query: 410 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 469
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 460 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 514
Query: 470 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 521
+N+ V+ + DG +WDLV + + + H +EFQI++S
Sbjct: 515 --DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 572
Query: 522 TDRKIAYWE 530
D I W+
Sbjct: 573 HDDTILIWD 581
Score = 62.8 bits (151), Expect = 9e-10
Identities = 67/254 (26%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 367 LLRITVPNMTCHGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 425
L RI + T G+ ++ D + I+S D I+ + T ++ H V +
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQY 351
Query: 426 TSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTC 485
D + +I+G + VRVW + T ++ L H +V + ++ NN VT S D +
Sbjct: 352 --DERVIITGSSDSTVRVWDVN--TGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSI 405
Query: 486 IIWDL-----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 540
+WD+ + LRR +++ + V +++ + SG DR I W +R L
Sbjct: 406 AVWDMASPTDITLRR--VLVGHRAAVNVVDFDDKYIVSASG-DRTIKVWNTSTCEFVRTL 462
Query: 541 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 600
G G I + V V+G +D+ +++WD G V GH + IR N+
Sbjct: 463 NGHKRG-IACLQYRDRLV--VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NK 517
Query: 601 YIVSVSADGAILRW 614
IVS + DG I W
Sbjct: 518 RIVSGAYDGKIKVW 531
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 444 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 503
W+ G + + E V C++ ++++ V+ D T IWD L +++ +T
Sbjct: 286 WRCGRHSLQRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 343
Query: 504 LFQCVCYHPEEFQIITSGTDRKIAYWEVFDG----TVIRELEGSLSGSI-NGMDITQEGV 558
+C +E IIT +D + W+V G T+I E L NGM
Sbjct: 344 -GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM------- 395
Query: 559 HFVTGGNDHLVKVWDY---NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
VT D + VWD + + V VGH + + ++YIVS S D I W
Sbjct: 396 -MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 451
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 18/180 (10%)
Query: 320 TDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHG 379
TD + H AV V F + + + I+VW+TS+ E +R N G
Sbjct: 414 TDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNTSTC-EFVRTL--NGHKRG 468
Query: 380 IDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGE 438
I ++ + ++S +D IR + E G + V+ H V I D KR++SG +
Sbjct: 469 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGAYD 525
Query: 439 GEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLV 491
G+++VW + A L EH V R++ + + V++S D T +IWD +
Sbjct: 526 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 583
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/249 (22%), Positives = 107/249 (42%), Gaps = 9/249 (3%)
Query: 331 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 390
H V I G A + I++W +S + L +T T G+ +
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
Query: 391 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 450
S D +++ + E +++ + H V + +++ + R+W + +T
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYHG-HLSAVYGLDLHPTIDVLVTCSRDSTARIWDV--RT 319
Query: 451 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN--TLFQCV 508
+ L H ++V+ +R + + +T S D T +WDLV + ++ L N + V
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA-GKTRVTLTNHKKSVRAV 378
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 568
HP + SG+ I W+ DG+ I+ L G + IN + + +GV V+G ++
Sbjct: 379 VLHPRHYTF-ASGSPDNIKQWKFPDGSFIQNLSGH-NAIINTLTVNSDGV-LVSGADNGT 435
Query: 569 VKVWDYNEG 577
+ +WD+ G
Sbjct: 436 MHLWDWRTG 444
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 2/164 (1%)
Query: 452 KLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCY 510
KL + H V CI V+ N+ VT S D T IWDL + + + + + V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 511 HPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVK 570
+ + G D+++ W++ VIR G LS ++ G+D+ VT D +
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLS-AVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 571 VWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
+WD H GH+ + +R I++ S D I W
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Score = 38.9 bits (89), Expect = 0.014
Identities = 17/59 (28%), Positives = 27/59 (45%)
Query: 560 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPY 618
FVTG D +K+WD G++ GH + + +S + Y+ S D + W Y
Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY 277
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 67.0 bits (162), Expect = 5e-11
Identities = 66/249 (26%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 296 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 353
+ L+ + + G+ +S ++ V+ + TLI H +AV + F G L TC+K
Sbjct: 284 LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH--HNEAVLHLRFSNG---LMVTCSK 338
Query: 354 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 409
+ I VW +S + L R+ V + + +DF D K I+SA D I+ ++ T +
Sbjct: 339 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFV 396
Query: 410 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 469
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 397 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 451
Query: 470 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 521
+N+ V+ + DG +WDL + + + + H +EFQII+S
Sbjct: 452 --DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 509
Query: 522 TDRKIAYWE 530
D I W+
Sbjct: 510 HDDTILIWD 518
Score = 60.1 bits (144), Expect = 6e-09
Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 385 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 444
D + IIS D I+ + + + V+ H V + D + +++G + VRVW
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTG-HTGSVLCLQY--DERVIVTGSSDSTVRVW 305
Query: 445 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-----VRLRRNQMI 499
+ T ++ L H +V + ++ +N VT S D + +WD+ + LRR ++
Sbjct: 306 DVN--TGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR--VL 359
Query: 500 LANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVH 559
+ + V +++ + SG DR I W +R L G G I + V
Sbjct: 360 VGHRAAVNVVDFDDKYIVSASG-DRTIKVWSTSTCEFVRTLNGHKRG-IACLQYRDRLV- 416
Query: 560 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
V+G +D+ +++WD G V GH + IR N+ IVS + DG I W
Sbjct: 417 -VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 568
C ++ +II+ D I W+ ++ L G +GS+ + + + VTG +D
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH-TGSVLCLQYDERVI--VTGSSDST 301
Query: 569 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
V+VWD N GEV + + H+ + +R S N +V+ S D +I W
Sbjct: 302 VRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 345
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 318 SFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTC 377
S TD + H AV V F + + + I+VW TS+ E +R N
Sbjct: 349 SATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTC-EFVRTL--NGHK 403
Query: 378 HGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGG 436
GI ++ + ++S +D IR + E G + V+ H V I D KR++SG
Sbjct: 404 RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGA 460
Query: 437 GEGEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
+G+++VW + A L EH V R++ + + +++S D T +IWD
Sbjct: 461 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWD 518
Query: 490 LVRL 493
+ +
Sbjct: 519 FLNV 522
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 67.0 bits (162), Expect = 5e-11
Identities = 66/249 (26%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 296 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 353
+ L+ + + G+ +S ++ V+ + TLI H +AV + F G L TC+K
Sbjct: 250 LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH--HNEAVLHLRFSNG---LMVTCSK 304
Query: 354 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 409
+ I VW +S + L R+ V + + +DF D K I+SA D I+ ++ T +
Sbjct: 305 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFV 362
Query: 410 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 469
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 363 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 417
Query: 470 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 521
+N+ V+ + DG +WDL + + + + H +EFQII+S
Sbjct: 418 --DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 475
Query: 522 TDRKIAYWE 530
D I W+
Sbjct: 476 HDDTILIWD 484
Score = 60.1 bits (144), Expect = 6e-09
Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 385 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 444
D + IIS D I+ + + + V+ H V + D + +++G + VRVW
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTG-HTGSVLCLQY--DERVIVTGSSDSTVRVW 271
Query: 445 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-----VRLRRNQMI 499
+ T ++ L H +V + ++ +N VT S D + +WD+ + LRR ++
Sbjct: 272 DVN--TGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR--VL 325
Query: 500 LANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVH 559
+ + V +++ + SG DR I W +R L G G I + V
Sbjct: 326 VGHRAAVNVVDFDDKYIVSASG-DRTIKVWSTSTCEFVRTLNGHKRG-IACLQYRDRLV- 382
Query: 560 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
V+G +D+ +++WD G V GH + IR N+ IVS + DG I W
Sbjct: 383 -VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Query: 509 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 568
C ++ +II+ D I W+ ++ L G +GS+ + + + VTG +D
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH-TGSVLCLQYDERVI--VTGSSDST 267
Query: 569 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
V+VWD N GEV + + H+ + +R S N +V+ S D +I W
Sbjct: 268 VRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 311
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 318 SFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTC 377
S TD + H AV V F + + + I+VW TS+ E +R N
Sbjct: 315 SATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTC-EFVRTL--NGHK 369
Query: 378 HGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGG 436
GI ++ + ++S +D IR + E G + V+ H V I D KR++SG
Sbjct: 370 RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGA 426
Query: 437 GEGEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
+G+++VW + A L EH V R++ + + +++S D T +IWD
Sbjct: 427 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWD 484
Query: 490 LVRL 493
+ +
Sbjct: 485 FLNV 488
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,285,908
Number of Sequences: 37866
Number of extensions: 1084705
Number of successful extensions: 4273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 2135
Number of HSP's gapped (non-prelim): 1407
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.