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Search of human proteins with 124028510
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124028510 WD40-repeat protein upregulated in HCC isoform c
[Homo sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H... 1126 0.0
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 1083 0.0
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 94 4e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 94 4e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 1e-16
gi|26665869 WD repeat domain 51B [Homo sapiens] 77 4e-14
gi|94400919 WD repeat domain 90 [Homo sapiens] 77 5e-14
gi|16554629 WD repeat domain 5 [Homo sapiens] 74 5e-13
gi|16554627 WD repeat domain 5 [Homo sapiens] 74 5e-13
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 70 7e-12
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 70 7e-12
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 69 1e-11
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 69 1e-11
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 69 1e-11
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 69 1e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 69 1e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 69 1e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 68 2e-11
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 68 2e-11
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 68 2e-11
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 68 2e-11
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 68 2e-11
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 67 4e-11
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 67 4e-11
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 67 4e-11
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 67 6e-11
gi|113865883 WD repeat domain 38 [Homo sapiens] 67 6e-11
gi|148727341 serine/threonine kinase receptor associated protein... 66 9e-11
gi|21071067 TBP-associated factor 5 [Homo sapiens] 65 2e-10
gi|13376840 WD repeat domain 61 [Homo sapiens] 65 2e-10
>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
sapiens]
Length = 552
Score = 1126 bits (2912), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MDNKISPEAQVAELELDAVIGFNDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVS 60
MDNKISPEAQVAELELDAVIGFNDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVS
Sbjct: 1 MDNKISPEAQVAELELDAVIGFNDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVS 60
Query: 61 LGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD 120
LGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD
Sbjct: 61 LGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD 120
Query: 121 LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDK 180
LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDK
Sbjct: 121 LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDK 180
Query: 181 FSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVG 240
FSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVG
Sbjct: 181 FSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVG 240
Query: 241 TEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELL 300
TEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELL
Sbjct: 241 TEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELL 300
Query: 301 RITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSD 360
RITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSD
Sbjct: 301 RITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSD 360
Query: 361 CKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW 420
CKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW
Sbjct: 361 CKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW 420
Query: 421 DLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSI 480
DLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSI
Sbjct: 421 DLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSI 480
Query: 481 NGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 540
NGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD
Sbjct: 481 NGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 540
Query: 541 GAILRWKYPYTS 552
GAILRWKYPYTS
Sbjct: 541 GAILRWKYPYTS 552
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 1083 bits (2800), Expect = 0.0
Identities = 531/534 (99%), Positives = 532/534 (99%), Gaps = 1/534 (0%)
Query: 20 IGFN-DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD 78
+GF DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD
Sbjct: 87 MGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRD 146
Query: 79 AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR 138
AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR
Sbjct: 147 AICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKR 206
Query: 139 IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV 198
IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV
Sbjct: 207 IVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLV 266
Query: 199 GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL 258
GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL
Sbjct: 267 GSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETL 326
Query: 259 IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG 318
IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG
Sbjct: 327 IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDG 386
Query: 319 KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 378
KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI
Sbjct: 387 KSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 446
Query: 379 GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ 438
GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ
Sbjct: 447 GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQ 506
Query: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND
Sbjct: 507 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
Query: 499 HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 552
HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS
Sbjct: 567 HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 620
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 93.6 bits (231), Expect = 4e-19
Identities = 69/286 (24%), Positives = 116/286 (40%), Gaps = 5/286 (1%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H DAV + F T +L + + VWH R T ++F G +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
S D +R + P V AH V ++ SD + ++ + V+VW
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFR-AHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHR 134
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VC 441
QK +L +H + V C + + V+AS D T +WD + F V
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 442 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 501
+HP I +G D + W+V +++ + S ++NG+ G + +T +D +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTL 253
Query: 502 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 547
K+ D EG + + GH G T + S +Y S +D ++ WK
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 73.9 bits (180), Expect = 3e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 261 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 320
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 321 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 380
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 174
Query: 381 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 438
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 233
Query: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 292
Query: 499 HLVKVWDYN-----EGEVTHV 514
V VW N GEVT V
Sbjct: 293 EQVMVWKSNFDIVDHGEVTKV 313
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCYH 443
LE K H+ +V+C+ N ++ + S D ++W + R + CV +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 444 PEEFQIITSGTDRKIAYW---EVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
P + + D+ + W + TV R + + ++ + +G FVT +D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFR----AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 501 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
VKVW + + H + + SP + IVS S D + W
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 35.8 bits (81), Expect = 0.10
Identities = 22/96 (22%), Positives = 41/96 (42%), Gaps = 5/96 (5%)
Query: 23 NDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICG 82
N + +WD + LL LH + L+F P+ YL++ D ++ + + + +
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT--ASSDSTLKILDLMEGRLLYT 266
Query: 83 SPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 118
+ G AT V FSR + + + VW+
Sbjct: 267 LHG---HQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 93.6 bits (231), Expect = 4e-19
Identities = 69/286 (24%), Positives = 116/286 (40%), Gaps = 5/286 (1%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H DAV + F T +L + + VWH R T ++F G +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
S D +R + P V AH V ++ SD + ++ + V+VW
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFR-AHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHR 134
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VC 441
QK +L +H + V C + + V+AS D T +WD + F V
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 442 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 501
+HP I +G D + W+V +++ + S ++NG+ G + +T +D +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTL 253
Query: 502 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 547
K+ D EG + + GH G T + S +Y S +D ++ WK
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 73.9 bits (180), Expect = 3e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 261 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 320
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 321 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 380
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 174
Query: 381 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 438
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 233
Query: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 292
Query: 499 HLVKVWDYN-----EGEVTHV 514
V VW N GEVT V
Sbjct: 293 EQVMVWKSNFDIVDHGEVTKV 313
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/166 (22%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCYH 443
LE K H+ +V+C+ N ++ + S D ++W + R + CV +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 444 PEEFQIITSGTDRKIAYW---EVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
P + + D+ + W + TV R + + ++ + +G FVT +D
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFR----AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 501 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
VKVW + + H + + SP + IVS S D + W
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 35.8 bits (81), Expect = 0.10
Identities = 22/96 (22%), Positives = 41/96 (42%), Gaps = 5/96 (5%)
Query: 23 NDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICG 82
N + +WD + LL LH + L+F P+ YL++ D ++ + + + +
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT--ASSDSTLKILDLMEGRLLYT 266
Query: 83 SPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 118
+ G AT V FSR + + + VW+
Sbjct: 267 LHG---HQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.5 bits (210), Expect = 1e-16
Identities = 62/261 (23%), Positives = 106/261 (40%), Gaps = 5/261 (1%)
Query: 288 IRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 347
+ VWH R T ++F G + S D +R + P V A
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR-A 63
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H V ++ SD + ++ + V+VW QK +L +H + V C + +
Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWEVFDG 466
V+AS D T +WD + F V +HP I +G D + W+V
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIR 526
+++ + S ++NG+ G + +T +D +K+ D EG + + GH G T +
Sbjct: 182 RLLQHYQLH-SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 527 ISPGNQYIVSVSADGAILRWK 547
S +Y S +D ++ WK
Sbjct: 241 FSRTGEYFASGGSDEQVMVWK 261
Score = 73.9 bits (180), Expect = 3e-13
Identities = 60/261 (22%), Positives = 111/261 (42%), Gaps = 12/261 (4%)
Query: 261 TCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKS 320
T H DAV + F L + K +R+W + E T + F DG+S
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 321 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC 380
++A +D ++ +A + ++ ++ H V + D + ++S + V++W
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVSASDDKTVKLWD--K 136
Query: 381 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRR--NQMILANTLFQ 438
+++ + EH V+ + + A D T +WD VR R L +
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVN 195
Query: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
+ +HP +IT+ +D + ++ +G ++ L G G + ++ G +F +GG+D
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH-QGPATTVAFSRTGEYFASGGSD 254
Query: 499 HLVKVWDYN-----EGEVTHV 514
V VW N GEVT V
Sbjct: 255 EQVMVWKSNFDIVDHGEVTKV 275
Score = 35.8 bits (81), Expect = 0.10
Identities = 22/96 (22%), Positives = 41/96 (42%), Gaps = 5/96 (5%)
Query: 23 NDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICG 82
N + +WD + LL LH + L+F P+ YL++ D ++ + + + +
Sbjct: 171 NTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT--ASSDSTLKILDLMEGRLLYT 228
Query: 83 SPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 118
+ G AT V FSR + + + VW+
Sbjct: 229 LHG---HQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 77.0 bits (188), Expect = 4e-14
Identities = 56/261 (21%), Positives = 111/261 (42%), Gaps = 5/261 (1%)
Query: 288 IRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 347
+ +W+ + R + F G + SA D +R + P+ R + A
Sbjct: 42 LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDK-RGKFSEFKA 100
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H V ++ ++D + + + + ++VW + Q+ +L H V C + +
Sbjct: 101 HTAPVRSVDFSADGQFLATASEDKSIKVWSM--YRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDG 466
V+ S D T IWD + + F V ++P I ++G+D+ + W+V
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIR 526
+++ + SG +N + G + +T +D +K+ D EG + + GH+G + +
Sbjct: 219 KLLQHYQVH-SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 527 ISPGNQYIVSVSADGAILRWK 547
S G + S AD +L W+
Sbjct: 278 FSKGGELFASGGADTQVLLWR 298
Score = 75.9 bits (185), Expect = 9e-14
Identities = 57/235 (24%), Positives = 101/235 (42%), Gaps = 9/235 (3%)
Query: 312 IDFMRDGKSIISAWNDGKIRA--FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGG 369
+D +GK + +A D + F P YV H+ VT++ + + S
Sbjct: 24 LDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV---GHKDVVTSVQFSPHGNLLASASR 80
Query: 370 EGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQ 429
+ VR+W I + K E K H + V + + + TAS D + +W + R R
Sbjct: 81 DRTVRLW-IPDKRGKFSE-FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLY 138
Query: 430 MILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQE 488
+ +T + +C + P+ I++ D+ I W+ + + S+ G N +D
Sbjct: 139 SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV-GFANFVDFNPS 197
Query: 489 GVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAI 543
G + G+D VKVWD ++ HSG + I P Y+++ S+DG +
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Score = 67.4 bits (163), Expect = 3e-11
Identities = 63/298 (21%), Positives = 124/298 (41%), Gaps = 19/298 (6%)
Query: 222 QGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVF-PFGTAELF 280
+ ITS+ L G Q + ++ + +F H D V + F P G L
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LA 76
Query: 281 ATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRL 340
+ + +R+W + +DF DG+ + +A D I+ ++ R
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
Query: 341 MYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIR 400
+Y + H V + D + ++S + +++W T K + + SV
Sbjct: 137 LYSLYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWD---TTNK--QCVNNFSDSVGFAN 190
Query: 401 VKRNNEE--CV-TASTDGTCIIWDLVRLRRNQMI----LANTLFQCVCYHPEEFQIITSG 453
N C+ +A +D T +WD +R N+++ + + C+ +HP +IT+
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWD---VRVNKLLQHYQVHSGGVNCISFHPSGNYLITAS 247
Query: 454 TDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEV 511
+D + ++ +G +I L+G +G + + ++ G F +GG D V +W N E+
Sbjct: 248 SDGTLKILDLLEGRLIYTLQGH-TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Score = 50.8 bits (120), Expect = 3e-06
Identities = 35/163 (21%), Positives = 66/163 (40%), Gaps = 2/163 (1%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-VRLRRNQMILANTLFQCVCYH 443
LE K HK++++ + + N ++ TAS D ++W+ R + + + V +
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 444 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 503
P + ++ DR + W E + + + +D + +G T D +KV
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAH-TAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 504 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
W + H+ + + SP + IVS S D I W
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Score = 32.0 bits (71), Expect = 1.5
Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 6/120 (5%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSP 84
I +WD N++ + S G + F+P+ + S G D +V VW + +
Sbjct: 168 IKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAG--SDQTVKVWDVRVNKLL---Q 222
Query: 85 AAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIG 144
++ G + F + + + +GT+++ +L L R I+ + TG + + S G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL-LEGRLIYTLQGHTGPVFTVSFSKG 281
Score = 31.2 bits (69), Expect = 2.6
Identities = 22/92 (23%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
+WD + +LL +H G + ++F P+ YL++ DG++ + + + I
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT--ASSDGTLKILDLLEGRLIYTLQG- 268
Query: 87 GLNVGNATNVIFSRCRDEMFMTAGNGT-IRVW 117
+ G V FS+ E+F + G T + +W
Sbjct: 269 --HTGPVFTVSFSK-GGELFASGGADTQVLLW 297
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 76.6 bits (187), Expect = 5e-14
Identities = 98/427 (22%), Positives = 167/427 (39%), Gaps = 60/427 (14%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS- 83
I +WD + H + ALAFSP+D LV+LG D ++ +W A D + +
Sbjct: 1188 IRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTR 1247
Query: 84 ---PAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPN--------RKIWPTECQ 132
P G V F+ G GT+ W L R+ P
Sbjct: 1248 LPEPVHG--------VAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVG 1299
Query: 133 TGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLK 192
G+L + Y GT++G + + R A D G +
Sbjct: 1300 AGELTSLCYGA-----PPLLYCGTSSGQVCVWDTRAGRCFLSWEADD----GGIGLLLFS 1350
Query: 193 MGGLLVGSGAGLL----------VFCKSPGYKPI---KKIQLQGGITSITLRGEGHQFLV 239
L+ GS G L + CK G + ++ L G + S + +V
Sbjct: 1351 GSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVV 1410
Query: 240 GTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKK-DIRVWHTSSNRE 298
GT ++ VS+ + T + + H V ++VF G + ATC++ +RVW +S
Sbjct: 1411 GTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHC-ATCSEDGSVRVWALASMEL 1469
Query: 299 LLRITVPNMTCHGIDF------MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV 352
+++ V N +C + + + + + + + DG +R F+ + M + + H + +
Sbjct: 1470 VIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFS-VSRTAMELKMHPHPVAL 1528
Query: 353 TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKS---SVSCIRVKRNNEECV 409
T +A ++D + V+SG +G V V C T L +H+ S C+ K EC
Sbjct: 1529 TTVAFSTDGQTVLSGDKDGLVAV-SHPC-TGTTFRVLSDHQGAPISTICVTCK----ECE 1582
Query: 410 TASTDGT 416
+GT
Sbjct: 1583 DLGVEGT 1589
Score = 73.6 bits (179), Expect = 5e-13
Identities = 108/569 (18%), Positives = 211/569 (37%), Gaps = 58/569 (10%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGS--VVVWSIAK-----RDA 79
LWD++ L + +L+FS + L +G G VV W +
Sbjct: 437 LWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVV 496
Query: 80 ICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPT---ECQTGQL 136
+ +V F R + G G++R+W L + P E Q
Sbjct: 497 VLAKAHTDFDVQAFRVTFFDETR---MASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQF 553
Query: 137 KRIVMSIGVDD----DDSFFYLGTTTGDILKMNPRTKLLTDVG------------PAKDK 180
+ D + ++ + +G IL+++ + ++ P K
Sbjct: 554 TDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQT 613
Query: 181 FSLGVS-AIRCLKMGGLL--VGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQF 237
FS G AI L + + VGS G L + + + +G ++S+ + +G +
Sbjct: 614 FSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRV 673
Query: 238 LVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNR 297
L T H+ + ++A H V + +L + +R+W ++ +
Sbjct: 674 LSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQ 733
Query: 298 ELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 357
+L T + F + ++ G +R+F+ E ++ V + HR VT +
Sbjct: 734 QLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVL-VEHTCHRGAVTGLTA 792
Query: 358 TSDCKRVISGGGEGEVRVWQIGCQTQK-------LEEALKEHKSSVSCIRVKRNNEECV- 409
T D + + S +G + Q C + + + +S S + V R+
Sbjct: 793 TPDGRLLFSSCSQGSLA--QYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAF 850
Query: 410 ------TASTDGTCIIWDLVRLRRNQMILANTLFQ---CVCYHPEEF-QIITSGTDRKIA 459
T + G+ + +L+R+ + LA++ VC+ P ++ S + ++
Sbjct: 851 VGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVV 910
Query: 460 YWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDY--NEGEVTHVGVG 517
+ G +IREL G + ++++ F+ +KVWDY V +G
Sbjct: 911 VLDAVSGRIIRELPGVHPEPCPSLTLSEDA-RFLLIAAGRTIKVWDYATQASPGPQVYIG 969
Query: 518 HSGNITRIRISPGNQYIVSVSADGAILRW 546
HS + + SP Q + +SA A+ W
Sbjct: 970 HSEPVQAVAFSPDQQQV--LSAGDAVFLW 996
Score = 31.2 bits (69), Expect = 2.6
Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 6/83 (7%)
Query: 467 TVIRELEGSLSGSINGM---DITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNIT 523
+V E E L G++ D GV T G V + EG T + GH +
Sbjct: 1383 SVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVS---WAEGTSTRLISGHRSKVN 1439
Query: 524 RIRISPGNQYIVSVSADGAILRW 546
+ SPG + + S DG++ W
Sbjct: 1440 EVVFSPGESHCATCSEDGSVRVW 1462
Score = 29.3 bits (64), Expect = 9.8
Identities = 32/152 (21%), Positives = 53/152 (34%), Gaps = 12/152 (7%)
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLR-------RN 428
W G T+ + H+S V+ + C T S DG+ +W L + N
Sbjct: 1422 WAEGTSTR----LISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLN 1477
Query: 429 QMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQE 488
Q L C PE+ ++ D + + V T + ++ + + +
Sbjct: 1478 QSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSV-SRTAMELKMHPHPVALTTVAFSTD 1536
Query: 489 GVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSG 520
G ++G D LV V G V H G
Sbjct: 1537 GQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQG 1568
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 73.6 bits (179), Expect = 5e-13
Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 11/292 (3%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H AV + F L ++ A K I++W + I+ + + + D ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
SA +D ++ + +G+ + + H V ++SG + VR+W + +T
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KT 160
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 440
K + L H VS + R+ V++S DG C IWD + + ++ N V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 497
+ P I+ + D + W+ G ++ G + +T G V+G
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 279
Query: 498 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA--DGAILRWK 547
D+LV +W+ E+ GH+ + P I S + D I WK
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 69.3 bits (168), Expect = 9e-12
Identities = 41/203 (20%), Positives = 94/203 (46%), Gaps = 5/203 (2%)
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H V+++ + + + + S + +++W G K E+ + HK +S + ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 466
V+AS D T IWD+ + + + ++ + C ++P+ I++ D + W+V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 525
++ L S ++ + ++G V+ D L ++WD G+ + ++ +
Sbjct: 162 KCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 526 RISPGNQYIVSVSADGAILRWKY 548
+ SP +YI++ + D + W Y
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDY 243
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 443
L+ L H +VS ++ N E ++S D IW + + I + L V +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 444 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 503
+ ++++ D+ + W+V G ++ L+G S + + + V+G D V++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 504 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
WD G+ HS ++ + + IVS S DG W
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 30.8 bits (68), Expect = 3.4
Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 5/92 (5%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
+WD + + L L H + F+P +VS G D SV +W + + PA
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVRIWDVKTGKCLKTLPA- 169
Query: 87 GLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 118
+ + V F+R + ++ +G R+W+
Sbjct: 170 --HSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 73.6 bits (179), Expect = 5e-13
Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 11/292 (3%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H AV + F L ++ A K I++W + I+ + + + D ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
SA +D ++ + +G+ + + H V ++SG + VR+W + +T
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KT 160
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 440
K + L H VS + R+ V++S DG C IWD + + ++ N V
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 497
+ P I+ + D + W+ G ++ G + +T G V+G
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 279
Query: 498 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA--DGAILRWK 547
D+LV +W+ E+ GH+ + P I S + D I WK
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 69.3 bits (168), Expect = 9e-12
Identities = 41/203 (20%), Positives = 94/203 (46%), Gaps = 5/203 (2%)
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H V+++ + + + + S + +++W G K E+ + HK +S + ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 466
V+AS D T IWD+ + + + ++ + C ++P+ I++ D + W+V G
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 525
++ L S ++ + ++G V+ D L ++WD G+ + ++ +
Sbjct: 162 KCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 526 RISPGNQYIVSVSADGAILRWKY 548
+ SP +YI++ + D + W Y
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDY 243
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 443
L+ L H +VS ++ N E ++S D IW + + I + L V +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 444 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 503
+ ++++ D+ + W+V G ++ L+G S + + + V+G D V++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 504 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
WD G+ HS ++ + + IVS S DG W
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 30.8 bits (68), Expect = 3.4
Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 5/92 (5%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
+WD + + L L H + F+P +VS G D SV +W + + PA
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVRIWDVKTGKCLKTLPA- 169
Query: 87 GLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 118
+ + V F+R + ++ +G R+W+
Sbjct: 170 --HSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 69.7 bits (169), Expect = 7e-12
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 16/203 (7%)
Query: 351 GVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVT 410
G+T+I S +++ + R+W + +L L H V + +N V+
Sbjct: 368 GITSIEFDSAGSYLLAASNDFASRIWTV--DDYRLRHTLTGHSGKVLSAKFLLDNARIVS 425
Query: 411 ASTDGTCIIWDLVRLRRNQMILANTLF---QCVCYHPEEFQIITSGTDRKIAYWEVFDGT 467
S D T +WDL + T+F C E +++ D+KI +W++ +
Sbjct: 426 GSHDRTLKLWDL-----RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 480
Query: 468 VIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHV----GVGHSGNIT 523
++RE+E L G I +D+ E ++ D L+KV D + G + T
Sbjct: 481 IVREME--LLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 538
Query: 524 RIRISPGNQYIVSVSADGAILRW 546
R+ SP Y+ + SA+G++ W
Sbjct: 539 RVVFSPDGSYVAAGSAEGSLYIW 561
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 440 VCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGG 496
V + P + T G DR++ WEVF E +GSLSGS I ++ G + +
Sbjct: 328 VQFSPGSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAAS 385
Query: 497 NDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
ND ++W ++ + H GHSG + + N IVS S D + W
Sbjct: 386 NDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Score = 38.1 bits (87), Expect = 0.021
Identities = 62/322 (19%), Positives = 115/322 (35%), Gaps = 50/322 (15%)
Query: 221 LQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDA----VEDIVFPFGT 276
L IT+I R F V + + S + + A C FDA V + F G+
Sbjct: 275 LLDSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGS 334
Query: 277 AELFATCAKKDIRVWHTSSNRELLR--ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFA 334
L + +++W + + ++ N I+F G +++A ND R +
Sbjct: 335 RLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWT 394
Query: 335 PETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQ----------------- 377
+ RL + + H V + D R++SG + +++W
Sbjct: 395 VDDYRLRHTLTG-HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCN 453
Query: 378 -IGCQTQ----------------KLEEALKEHK--SSVSCIRVKRNNEECVTASTDGTCI 418
I C Q + E ++E + ++ + + E ++ S D
Sbjct: 454 DIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLK 513
Query: 419 IWDLVRLRRNQMILANTLFQC------VCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 472
+ DL R + + F+C V + P+ + + + W V G V + L
Sbjct: 514 VIDL-RTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVL 572
Query: 473 EGSLSGSINGMDITQEGVHFVT 494
S SIN + + G H V+
Sbjct: 573 SKQHSSSINAVAWSPSGSHVVS 594
Score = 30.8 bits (68), Expect = 3.4
Identities = 19/79 (24%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 42 HKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRC 101
H G++ A+ FSP L + G D V +W + +G N G T++ F
Sbjct: 321 HDGEVNAVQFSPGSRLLAT--GGMDRRVKLWEVFGEKCEFKGSLSGSNAG-ITSIEFDSA 377
Query: 102 RDEMFMTAGNGTIRVWELD 120
+ + + R+W +D
Sbjct: 378 GSYLLAASNDFASRIWTVD 396
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 69.7 bits (169), Expect = 7e-12
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 16/203 (7%)
Query: 351 GVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVT 410
G+T+I S +++ + R+W + +L L H V + +N V+
Sbjct: 349 GITSIEFDSAGSYLLAASNDFASRIWTV--DDYRLRHTLTGHSGKVLSAKFLLDNARIVS 406
Query: 411 ASTDGTCIIWDLVRLRRNQMILANTLF---QCVCYHPEEFQIITSGTDRKIAYWEVFDGT 467
S D T +WDL + T+F C E +++ D+KI +W++ +
Sbjct: 407 GSHDRTLKLWDL-----RSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSES 461
Query: 468 VIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHV----GVGHSGNIT 523
++RE+E L G I +D+ E ++ D L+KV D + G + T
Sbjct: 462 IVREME--LLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWT 519
Query: 524 RIRISPGNQYIVSVSADGAILRW 546
R+ SP Y+ + SA+G++ W
Sbjct: 520 RVVFSPDGSYVAAGSAEGSLYIW 542
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 440 VCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGG 496
V + P + T G DR++ WEVF E +GSLSGS I ++ G + +
Sbjct: 309 VQFSPGSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAAS 366
Query: 497 NDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
ND ++W ++ + H GHSG + + N IVS S D + W
Sbjct: 367 NDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Score = 37.4 bits (85), Expect = 0.036
Identities = 46/229 (20%), Positives = 85/229 (37%), Gaps = 16/229 (6%)
Query: 274 FGTAELFATCAKKDI--RVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIR 331
F +A + A D R+W R +T + F+ D I+S +D ++
Sbjct: 355 FDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLK 414
Query: 332 AFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKE 391
+ + + + I T C V+SG + ++R W I ++ E L
Sbjct: 415 LWDLRSKVCIKTVFAGS--SCNDIVCTEQC--VMSGHFDKKIRFWDIRSESIVREMELL- 469
Query: 392 HKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC------VCYHPE 445
++ + + E ++ S D + DL R + + F+C V + P+
Sbjct: 470 --GKITALDLNPERTELLSCSRDDLLKVIDL-RTNAIKQTFSAPGFKCGSDWTRVVFSPD 526
Query: 446 EFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
+ + + W V G V + L S SIN + + G H V+
Sbjct: 527 GSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 575
Score = 30.8 bits (68), Expect = 3.4
Identities = 19/79 (24%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 42 HKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRC 101
H G++ A+ FSP L + G D V +W + +G N G T++ F
Sbjct: 302 HDGEVNAVQFSPGSRLLAT--GGMDRRVKLWEVFGEKCEFKGSLSGSNAG-ITSIEFDSA 358
Query: 102 RDEMFMTAGNGTIRVWELD 120
+ + + R+W +D
Sbjct: 359 GSYLLAASNDFASRIWTVD 377
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 68.9 bits (167), Expect = 1e-11
Identities = 40/185 (21%), Positives = 74/185 (40%), Gaps = 14/185 (7%)
Query: 381 QTQKLEEALKEH-----KSSVSCIRVKRNNEECVTASTDGTCIIW---------DLVRLR 426
+ +K L H KS V C R + + VT S DG +W DL
Sbjct: 197 EEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQA 256
Query: 427 RNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDIT 486
++ ++ + C+C+ + + T D KI W++ G +R E + S + + +
Sbjct: 257 QDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFS 316
Query: 487 QEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
++ ++ D +++ G+ GHS + + YI+S S+DG + W
Sbjct: 317 KDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Query: 547 KYPYT 551
T
Sbjct: 377 NMKTT 381
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 25/250 (10%)
Query: 314 FMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEV 373
F RD + + + DGKI+ + ++G+ + AH GVT ++ + D +++S + +
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 374 RVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQM--- 430
R+ G ++ K + + H S V+ ++ ++AS+DGT IW++ +
Sbjct: 332 RIH--GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 389
Query: 431 --------ILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSING 482
I N++ + +PE F + I + G ++R SG G
Sbjct: 390 LGSTAGTDITVNSVI-LLPKNPEHFVVCNRSNTVVIMNMQ---GQIVRSFS---SGKREG 442
Query: 483 MD-----ITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSV 537
D ++ G G D ++ + G++ H ++ I P I +
Sbjct: 443 GDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATY 502
Query: 538 SADGAILRWK 547
S DG + WK
Sbjct: 503 SEDGLLKLWK 512
Score = 31.6 bits (70), Expect = 2.0
Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 12/101 (11%)
Query: 29 DYKNRELLARLSLH-----KGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIA----KRDA 79
D + + +LS H K +E FSP+ YLV+ G DG + VW+ ++D
Sbjct: 195 DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVT--GSVDGFIEVWNFTTGKIRKDL 252
Query: 80 ICGSPAAGLNVGNAT-NVIFSRCRDEMFMTAGNGTIRVWEL 119
+ + + +A + FSR + + A +G I+VW++
Sbjct: 253 KYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKI 293
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 68.6 bits (166), Expect = 1e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 318 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 375
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 327
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 435
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 328 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 383
Query: 436 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 384 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 438
Query: 495 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 439 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 488
Score = 60.5 bits (145), Expect = 4e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 315 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 374
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 311 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 366
Query: 375 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 434
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 367 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 422
Query: 435 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 423 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 478
Query: 495 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 546
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 479 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 531
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 448
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 436
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 449 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 504
Query: 437 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 483
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 505 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 553
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 68.6 bits (166), Expect = 1e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 318 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 375
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 445
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 435
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 446 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 501
Query: 436 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 502 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 556
Query: 495 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 557 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 606
Score = 60.5 bits (145), Expect = 4e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 315 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 374
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 429 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 484
Query: 375 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 434
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 485 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540
Query: 435 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 541 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 596
Query: 495 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 546
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 597 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 649
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 566
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 436
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 567 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 622
Query: 437 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 483
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 623 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 671
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 68.6 bits (166), Expect = 1e-11
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 318 GKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKR--VISGGGEGEVRV 375
G I+S +D ++ ++ TG+ + + +G T +S + +ISG + ++V
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTL-----VGHTGGVWSSQMRDNIIISGSTDRTLKV 365
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 435
W +T + L H S+V C+ + + + V+ S D T +WD+ + +++ +
Sbjct: 366 WN--AETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHV 421
Query: 436 L-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
+CV Y ++++ D + W+ T + L+G + + + +G+H V+
Sbjct: 422 AAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS---LQFDGIHVVS 476
Query: 495 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
G D ++VWD G H GH + + + + +VS +AD + W
Sbjct: 477 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIW 526
Score = 60.5 bits (145), Expect = 4e-09
Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 17/235 (7%)
Query: 315 MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVR 374
MRD IIS D ++ + ETG ++ + H V + KRV+SG + +R
Sbjct: 349 MRDN-IIISGSTDRTLKVWNAETGECIHTLYG-HTSTVRCMHLHE--KRVVSGSRDATLR 404
Query: 375 VWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN 434
VW I +T + L H ++V C++ + V+ + D +WD + +
Sbjct: 405 VWDI--ETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGH 460
Query: 435 TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVT 494
T + + +++ D I W+V G I L G S + +GM++ + V+
Sbjct: 461 TN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT-SGMELKDNIL--VS 516
Query: 495 GGNDHLVKVWDYNEGEVTHVGVG---HSGNITRIRISPGNQYIVSVSADGAILRW 546
G D VK+WD G+ G H +T ++ + ++++ S DG + W
Sbjct: 517 GNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 569
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
DG+ ++S D ++ + PET ++ + H V ++ D V+SG + +RVW
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQF--DGIHVVSGSLDTSIRVW 486
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 436
+ +T L H+S S + +K N V+ + D T IWD+ + Q +
Sbjct: 487 DV--ETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNK 542
Query: 437 FQCV--CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGM 483
Q C + +ITS D + W++ G IR L SG G+
Sbjct: 543 HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV 591
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 8/191 (4%)
Query: 359 SDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCI 418
+D ++S + +R W +G T + + H V + + + + S D T
Sbjct: 352 ADSSGLLSCSEDMSIRYWDLGSFTNTV--LYQGHAYPVWDLDISPYSLYFASGSHDRTAR 409
Query: 419 IWDLVR---LRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGS 475
+W R LR LA+ CV +HP + T TD+ + W G +R G
Sbjct: 410 LWSFDRTYPLRIYAGHLADV--DCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGH 467
Query: 476 LSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIV 535
G + + + G + + G D +K+WD G + GH+ NIT + SP + I
Sbjct: 468 -RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526
Query: 536 SVSADGAILRW 546
S S D ++ W
Sbjct: 527 SASMDNSVRVW 537
Score = 38.5 bits (88), Expect = 0.016
Identities = 26/95 (27%), Positives = 47/95 (49%), Gaps = 9/95 (9%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
LW + + + H+G + +LAFSPN YL S G +D + +W +A G+
Sbjct: 452 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG--EDQRLKLWDLAS-----GTLYK 504
Query: 87 GL--NVGNATNVIFSRCRDEMFMTAGNGTIRVWEL 119
L + N T++ FS + + + ++RVW++
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 36.6 bits (83), Expect = 0.062
Identities = 26/116 (22%), Positives = 46/116 (39%), Gaps = 1/116 (0%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H V+ + F + L K +R+W + T + F +GK +
Sbjct: 425 HLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLA 484
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI 378
SA D +++ + +G L Y H +T++ + D + S + VRVW I
Sbjct: 485 SAGEDQRLKLWDLASGTL-YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 35.4 bits (80), Expect = 0.14
Identities = 21/111 (18%), Positives = 53/111 (47%), Gaps = 3/111 (2%)
Query: 312 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 371
+ F + + + D +R ++ + G + + HR V ++A + + K + S G +
Sbjct: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG-HRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 372 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL 422
+++W + T L + L+ H +++ + ++ +AS D + +WD+
Sbjct: 491 RLKLWDLASGT--LYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 30.4 bits (67), Expect = 4.4
Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 25/155 (16%)
Query: 405 NEECVTASTDGTCI-IWDL----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIA 459
+ + + A D +CI +W L ++ +Q+ ++ C E+ + +GT+ KI
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKIL 338
Query: 460 YWE---VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGV 516
V+ + + G LS S D ++ WD T +
Sbjct: 339 RGHCGPVYSTRFLADSSGLLSCS-----------------EDMSIRYWDLGSFTNTVLYQ 381
Query: 517 GHSGNITRIRISPGNQYIVSVSADGAILRWKYPYT 551
GH+ + + ISP + Y S S D W + T
Sbjct: 382 GHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRT 416
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/283 (20%), Positives = 112/283 (39%), Gaps = 9/283 (3%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H +AV + F L ++ A + I +W + + N+ + + D ++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
SA +D ++ + +G+ + + H V +ISG + V++W++ +T
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKG-HSNYVFCCNFNPPSNLIISGSFDETVKIWEV--KT 156
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA--NTLFQCV 440
K + L H VS + + V+ S DG C IWD + + ++ N V
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS---INGMDITQEGVHFVTGGN 497
+ P I+T+ D + W+ G ++ G + +T G V+G
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSE 275
Query: 498 DHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 540
D+LV +W+ E+ GH+ + P I S + +
Sbjct: 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Score = 65.9 bits (159), Expect = 9e-11
Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 5/203 (2%)
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H V+++ + + + + S + + +W G K E+ L H +S + ++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIW--GAYDGKYEKTLYGHNLEISDVAWSSDSSR 97
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQIITSGTDRKIAYWEVFDG 466
V+AS D T +WD+ + + + ++ + C ++P II+ D + WEV G
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGN-ITRI 525
++ L S ++ + G V+G D L ++WD G+ V ++ +
Sbjct: 158 KCLKTLSAH-SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 526 RISPGNQYIVSVSADGAILRWKY 548
+ SP +YI++ + D + W Y
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDY 239
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/239 (20%), Positives = 105/239 (43%), Gaps = 7/239 (2%)
Query: 312 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 371
+ F +G+ + S+ D I + G+ + H + ++ +A +SD R++S +
Sbjct: 47 VKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG-HNLEISDVAWSSDSSRLVSASDDK 105
Query: 372 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 431
+++W + ++ K + LK H + V C + ++ S D T IW++ + + +
Sbjct: 106 TLKLWDV--RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 432 LANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGV 490
A++ V ++ I++ D W+ G ++ L + ++ + + G
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223
Query: 491 HFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRIS---PGNQYIVSVSADGAILRW 546
+ +T D+ +K+WDY+ G GH I + G ++IVS S D + W
Sbjct: 224 YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
Score = 56.2 bits (134), Expect = 8e-08
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 2/163 (1%)
Query: 385 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYH 443
L+ L H +VS ++ N E ++S D IIW + + + + L V +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 444 PEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKV 503
+ +++++ D+ + W+V G ++ L+G S + + ++G D VK+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH-SNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 504 WDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
W+ G+ HS ++ + + IVS S DG W
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/202 (22%), Positives = 87/202 (43%), Gaps = 5/202 (2%)
Query: 347 AHRIGVTAIATTSDCKRVISGGGEG-EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 405
AH V+++ R+++ GG+ V +W I + +L H S V +R+
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLNTPE 75
Query: 406 EECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWEVF 464
E V S G+ +WDL + + ++ + C + +HP + + D I W++
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 465 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 524
+ G S ++ + + +G + +DH VK+WD G++ GH+G +
Sbjct: 136 RKGCVFRYRGH-SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 525 IRISPGNQYIVSVSADGAILRW 546
+ P + S S+D I W
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFW 216
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/244 (20%), Positives = 100/244 (40%), Gaps = 14/244 (5%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRV--WHTSSNRELLRITVPNMTCHGIDFMRDGKS 320
H V +V + L AT D RV W + ++ +T + +
Sbjct: 19 HASNVSSLVLGKASGRLLAT-GGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 321 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQI-- 378
I++ G IR + E +++ + H+ + ++ + V SG + +++W I
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMG-HKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 379 -GCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-L 436
GC + + H +V C+R + + +A+ D T +WDL + +T
Sbjct: 137 KGCVFR-----YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 437 FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGG 496
V +HP E+ + + +DR I +W++ V+ +EG G + + +G +G
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGE-PGPVRSVLFNPDGCCLYSGC 250
Query: 497 NDHL 500
D L
Sbjct: 251 QDSL 254
Score = 35.8 bits (81), Expect = 0.10
Identities = 38/203 (18%), Positives = 72/203 (35%), Gaps = 4/203 (1%)
Query: 225 ITSITL-RGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATC 283
++S+ L + G G ++ + S + T H VE + + A
Sbjct: 23 VSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS 82
Query: 284 AKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYV 343
IRVW + + L + +DF G+ + S D I+ + ++
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 344 INNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKR 403
H V + + D K + S + V++W + K+ H V+ +
Sbjct: 143 Y-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL--TAGKMMSEFPGHTGPVNVVEFHP 199
Query: 404 NNEECVTASTDGTCIIWDLVRLR 426
N + S+D T WDL + +
Sbjct: 200 NEYLLASGSSDRTIRFWDLEKFQ 222
Score = 35.8 bits (81), Expect = 0.10
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 24 DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS 83
+I LWD + + + R H + L FSP+ +L S DD +V +W + +
Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS--AADDHTVKLWDLTAGKMMSEF 185
Query: 84 PAAGLNVGNATNVIFSRCRDEMFMTAGNG--TIRVWELD 120
P + G V F +E + +G+ TIR W+L+
Sbjct: 186 PG---HTGPVNVVEFH--PNEYLLASGSSDRTIRFWDLE 219
Score = 31.2 bits (69), Expect = 2.6
Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAI 80
I +WD + ++L L HK I +L F P ++ S G D ++ +W I ++ +
Sbjct: 87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVAS--GSQDTNIKLWDIRRKGCV 140
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 68.2 bits (165), Expect = 2e-11
Identities = 47/190 (24%), Positives = 88/190 (46%), Gaps = 4/190 (2%)
Query: 359 SDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCI 418
SD ++++GG + V V+ ++++ LK H V+ + + + +AS D T
Sbjct: 232 SDTNKILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 289
Query: 419 IWDLVRLRRNQMILAN-TLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS 477
IW + Q++ A+ + + H +++S D+ A+ ++ G V+ ++ S
Sbjct: 290 IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 349
Query: 478 G-SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVS 536
G S+ +G+ F TG D +K+WD E GHSG IT I S Y+ +
Sbjct: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409
Query: 537 VSADGAILRW 546
+ D ++ W
Sbjct: 410 AADDSSVKLW 419
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 23 NDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAK 76
+ I +WD K R +A H G I ++AFS N YL + DD SV +W + K
Sbjct: 372 SQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT--AADDSSVKLWDLRK 423
Score = 41.2 bits (95), Expect = 0.002
Identities = 54/282 (19%), Positives = 108/282 (38%), Gaps = 24/282 (8%)
Query: 273 PFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRA 332
P T ++ A K++ V+ SS + L + + F + SA D IR
Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
Query: 333 FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIG-CQTQKLEEALKE 391
++ + V+ AH VT ++ + ++S + + W QT ++ + +
Sbjct: 291 WSVPNASCVQVVR-AHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTD 346
Query: 392 HKS--SVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-----FQCVCYHP 444
S S++C + + T + D IWDL + + +AN + +
Sbjct: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL----KERTNVANFPGHSGPITSIAFSE 402
Query: 445 EEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND---HLV 501
+ + T+ D + W++ + L+ + + + Q G + GG D ++
Sbjct: 403 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYIC 462
Query: 502 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAI 543
K W E+ H HSG T + ++I S D ++
Sbjct: 463 KQWT----EILHF-TEHSGLTTGVAFGHHAKFIASTGMDRSL 499
Score = 36.2 bits (82), Expect = 0.080
Identities = 18/60 (30%), Positives = 27/60 (45%)
Query: 493 VTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS 552
+TGG D V V+D + ++ GH+ +T + P + S S D I W P S
Sbjct: 238 LTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS 297
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 7/92 (7%)
Query: 31 KNRELLARLSLHKGKIE---ALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAG 87
K R++ + + LH I AL P+D + GG D +VVV+ + +
Sbjct: 206 KYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADK-NVVVFDKSSEQILATLKG-- 262
Query: 88 LNVGNATNVIFSRCRDEMFMTAGNGTIRVWEL 119
+ T+V+F +D +F + + TIR+W +
Sbjct: 263 -HTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/249 (26%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 228 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 285
+ L+ + + G+ +S ++ V+ + TLI C +AV + F G + TC+K
Sbjct: 311 LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVLHLRFNNG---MMVTCSK 365
Query: 286 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ I VW +S + L R+ V + + +DF D K I+SA D I+ + T +
Sbjct: 366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFV 423
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 401
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 424 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 478
Query: 402 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 453
+N+ V+ + DG +WDLV + + + H +EFQI++S
Sbjct: 479 --DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 536
Query: 454 TDRKIAYWE 462
D I W+
Sbjct: 537 HDDTILIWD 545
Score = 62.8 bits (151), Expect = 8e-10
Identities = 67/254 (26%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 299 LLRITVPNMTCHGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 357
L RI + T G+ ++ D + I+S D I+ + T ++ H V +
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQY 315
Query: 358 TSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTC 417
D + +I+G + VRVW + T ++ L H +V + ++ NN VT S D +
Sbjct: 316 --DERVIITGSSDSTVRVWDVN--TGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSI 369
Query: 418 IIWDL-----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 472
+WD+ + LRR +++ + V +++ + SG DR I W +R L
Sbjct: 370 AVWDMASPTDITLRR--VLVGHRAAVNVVDFDDKYIVSASG-DRTIKVWNTSTCEFVRTL 426
Query: 473 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 532
G G I + V V+G +D+ +++WD G V GH + IR N+
Sbjct: 427 NGHKRG-IACLQYRDRLV--VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NK 481
Query: 533 YIVSVSADGAILRW 546
IVS + DG I W
Sbjct: 482 RIVSGAYDGKIKVW 495
Score = 49.3 bits (116), Expect = 9e-06
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 435
W+ G + + E V C++ ++++ V+ D T IWD L +++ +T
Sbjct: 250 WRCGRHSLQRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 307
Query: 436 LFQCVCYHPEEFQIITSGTDRKIAYWEVFDG----TVIRELEGSLSGSI-NGMDITQEGV 490
+C +E IIT +D + W+V G T+I E L NGM
Sbjct: 308 -GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM------- 359
Query: 491 HFVTGGNDHLVKVWDY---NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
VT D + VWD + + V VGH + + ++YIVS S D I W
Sbjct: 360 -MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 415
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 18/180 (10%)
Query: 252 TDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHG 311
TD + H AV V F + + + I+VW+TS+ E +R N G
Sbjct: 378 TDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNTSTC-EFVRTL--NGHKRG 432
Query: 312 IDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGE 370
I ++ + ++S +D IR + E G + V+ H V I D KR++SG +
Sbjct: 433 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGAYD 489
Query: 371 GEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLV 423
G+++VW + A L EH V R++ + + V++S D T +IWD +
Sbjct: 490 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 547
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/249 (26%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 228 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 285
+ L+ + + G+ +S ++ V+ + TLI C +AV + F G + TC+K
Sbjct: 347 LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVLHLRFNNG---MMVTCSK 401
Query: 286 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ I VW +S + L R+ V + + +DF D K I+SA D I+ + T +
Sbjct: 402 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFV 459
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 401
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 460 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 514
Query: 402 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 453
+N+ V+ + DG +WDLV + + + H +EFQI++S
Sbjct: 515 --DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSS 572
Query: 454 TDRKIAYWE 462
D I W+
Sbjct: 573 HDDTILIWD 581
Score = 62.8 bits (151), Expect = 8e-10
Identities = 67/254 (26%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 299 LLRITVPNMTCHGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 357
L RI + T G+ ++ D + I+S D I+ + T ++ H V +
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQY 351
Query: 358 TSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTC 417
D + +I+G + VRVW + T ++ L H +V + ++ NN VT S D +
Sbjct: 352 --DERVIITGSSDSTVRVWDVN--TGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSI 405
Query: 418 IIWDL-----VRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIREL 472
+WD+ + LRR +++ + V +++ + SG DR I W +R L
Sbjct: 406 AVWDMASPTDITLRR--VLVGHRAAVNVVDFDDKYIVSASG-DRTIKVWNTSTCEFVRTL 462
Query: 473 EGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQ 532
G G I + V V+G +D+ +++WD G V GH + IR N+
Sbjct: 463 NGHKRG-IACLQYRDRLV--VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NK 517
Query: 533 YIVSVSADGAILRW 546
IVS + DG I W
Sbjct: 518 RIVSGAYDGKIKVW 531
Score = 49.3 bits (116), Expect = 9e-06
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 376 WQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT 435
W+ G + + E V C++ ++++ V+ D T IWD L +++ +T
Sbjct: 286 WRCGRHSLQRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 343
Query: 436 LFQCVCYHPEEFQIITSGTDRKIAYWEVFDG----TVIRELEGSLSGSI-NGMDITQEGV 490
+C +E IIT +D + W+V G T+I E L NGM
Sbjct: 344 -GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGM------- 395
Query: 491 HFVTGGNDHLVKVWDY---NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
VT D + VWD + + V VGH + + ++YIVS S D I W
Sbjct: 396 -MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 451
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 18/180 (10%)
Query: 252 TDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHG 311
TD + H AV V F + + + I+VW+TS+ E +R N G
Sbjct: 414 TDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNTSTC-EFVRTL--NGHKRG 468
Query: 312 IDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGE 370
I ++ + ++S +D IR + E G + V+ H V I D KR++SG +
Sbjct: 469 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGAYD 525
Query: 371 GEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLV 423
G+++VW + A L EH V R++ + + V++S D T +IWD +
Sbjct: 526 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 583
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 67.8 bits (164), Expect = 2e-11
Identities = 55/249 (22%), Positives = 107/249 (42%), Gaps = 9/249 (3%)
Query: 263 HFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSII 322
H V I G A + I++W +S + L +T T G+ +
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
Query: 323 SAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT 382
S D +++ + E +++ + H V + +++ + R+W + +T
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYHG-HLSAVYGLDLHPTIDVLVTCSRDSTARIWDV--RT 319
Query: 383 QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN--TLFQCV 440
+ L H ++V+ +R + + +T S D T +WDLV + ++ L N + V
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA-GKTRVTLTNHKKSVRAV 378
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
HP + SG+ I W+ DG+ I+ L G + IN + + +GV V+G ++
Sbjct: 379 VLHPRHYTF-ASGSPDNIKQWKFPDGSFIQNLSGH-NAIINTLTVNSDGV-LVSGADNGT 435
Query: 501 VKVWDYNEG 509
+ +WD+ G
Sbjct: 436 MHLWDWRTG 444
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 2/164 (1%)
Query: 384 KLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILAN-TLFQCVCY 442
KL + H V CI V+ N+ VT S D T IWDL + + + + + V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 443 HPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVK 502
+ + G D+++ W++ VIR G LS ++ G+D+ VT D +
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLS-AVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 503 VWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
+WD H GH+ + +R I++ S D I W
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Score = 38.9 bits (89), Expect = 0.012
Identities = 17/59 (28%), Positives = 27/59 (45%)
Query: 492 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPY 550
FVTG D +K+WD G++ GH + + +S + Y+ S D + W Y
Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY 277
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 67.0 bits (162), Expect = 4e-11
Identities = 66/249 (26%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 228 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 285
+ L+ + + G+ +S ++ V+ + TLI H +AV + F G L TC+K
Sbjct: 284 LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH--HNEAVLHLRFSNG---LMVTCSK 338
Query: 286 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ I VW +S + L R+ V + + +DF D K I+SA D I+ ++ T +
Sbjct: 339 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFV 396
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 401
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 397 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 451
Query: 402 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 453
+N+ V+ + DG +WDL + + + + H +EFQII+S
Sbjct: 452 --DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 509
Query: 454 TDRKIAYWE 462
D I W+
Sbjct: 510 HDDTILIWD 518
Score = 60.1 bits (144), Expect = 5e-09
Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
D + IIS D I+ + + + V+ H V + D + +++G + VRVW
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTG-HTGSVLCLQY--DERVIVTGSSDSTVRVW 305
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-----VRLRRNQMI 431
+ T ++ L H +V + ++ +N VT S D + +WD+ + LRR ++
Sbjct: 306 DVN--TGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR--VL 359
Query: 432 LANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVH 491
+ + V +++ + SG DR I W +R L G G I + V
Sbjct: 360 VGHRAAVNVVDFDDKYIVSASG-DRTIKVWSTSTCEFVRTLNGHKRG-IACLQYRDRLV- 416
Query: 492 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+G +D+ +++WD G V GH + IR N+ IVS + DG I W
Sbjct: 417 -VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
C ++ +II+ D I W+ ++ L G +GS+ + + + VTG +D
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH-TGSVLCLQYDERVI--VTGSSDST 301
Query: 501 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+VWD N GEV + + H+ + +R S N +V+ S D +I W
Sbjct: 302 VRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 345
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 250 SFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTC 309
S TD + H AV V F + + + I+VW TS+ E +R N
Sbjct: 349 SATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTC-EFVRTL--NGHK 403
Query: 310 HGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGG 368
GI ++ + ++S +D IR + E G + V+ H V I D KR++SG
Sbjct: 404 RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGA 460
Query: 369 GEGEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 421
+G+++VW + A L EH V R++ + + +++S D T +IWD
Sbjct: 461 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWD 518
Query: 422 LVRL 425
+ +
Sbjct: 519 FLNV 522
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 67.0 bits (162), Expect = 4e-11
Identities = 66/249 (26%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 228 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 285
+ L+ + + G+ +S ++ V+ + TLI H +AV + F G L TC+K
Sbjct: 250 LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH--HNEAVLHLRFSNG---LMVTCSK 304
Query: 286 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ I VW +S + L R+ V + + +DF D K I+SA D I+ ++ T +
Sbjct: 305 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFV 362
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 401
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 363 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 417
Query: 402 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 453
+N+ V+ + DG +WDL + + + + H +EFQII+S
Sbjct: 418 --DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 475
Query: 454 TDRKIAYWE 462
D I W+
Sbjct: 476 HDDTILIWD 484
Score = 60.1 bits (144), Expect = 5e-09
Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
D + IIS D I+ + + + V+ H V + D + +++G + VRVW
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTG-HTGSVLCLQY--DERVIVTGSSDSTVRVW 271
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-----VRLRRNQMI 431
+ T ++ L H +V + ++ +N VT S D + +WD+ + LRR ++
Sbjct: 272 DVN--TGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR--VL 325
Query: 432 LANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVH 491
+ + V +++ + SG DR I W +R L G G I + V
Sbjct: 326 VGHRAAVNVVDFDDKYIVSASG-DRTIKVWSTSTCEFVRTLNGHKRG-IACLQYRDRLV- 382
Query: 492 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+G +D+ +++WD G V GH + IR N+ IVS + DG I W
Sbjct: 383 -VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
C ++ +II+ D I W+ ++ L G +GS+ + + + VTG +D
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH-TGSVLCLQYDERVI--VTGSSDST 267
Query: 501 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+VWD N GEV + + H+ + +R S N +V+ S D +I W
Sbjct: 268 VRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 311
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 250 SFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTC 309
S TD + H AV V F + + + I+VW TS+ E +R N
Sbjct: 315 SATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTC-EFVRTL--NGHK 369
Query: 310 HGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGG 368
GI ++ + ++S +D IR + E G + V+ H V I D KR++SG
Sbjct: 370 RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGA 426
Query: 369 GEGEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 421
+G+++VW + A L EH V R++ + + +++S D T +IWD
Sbjct: 427 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWD 484
Query: 422 LVRL 425
+ +
Sbjct: 485 FLNV 488
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 67.0 bits (162), Expect = 4e-11
Identities = 66/249 (26%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 228 ITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAK 285
+ L+ + + G+ +S ++ V+ + TLI H +AV + F G L TC+K
Sbjct: 271 LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH--HNEAVLHLRFSNG---LMVTCSK 325
Query: 286 -KDIRVWHTSSNRE--LLRITVPNMTC-HGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ I VW +S + L R+ V + + +DF D K I+SA D I+ ++ T +
Sbjct: 326 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFV 383
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRV 401
+N H+ G+ + + V+SG + +R+W I C L+ H+ V CIR
Sbjct: 384 RTLNG-HKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF 438
Query: 402 KRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHP--------EEFQIITSG 453
+N+ V+ + DG +WDL + + + + H +EFQII+S
Sbjct: 439 --DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSS 496
Query: 454 TDRKIAYWE 462
D I W+
Sbjct: 497 HDDTILIWD 505
Score = 60.1 bits (144), Expect = 5e-09
Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 317 DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVW 376
D + IIS D I+ + + + V+ H V + D + +++G + VRVW
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTG-HTGSVLCLQY--DERVIVTGSSDSTVRVW 292
Query: 377 QIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL-----VRLRRNQMI 431
+ T ++ L H +V + ++ +N VT S D + +WD+ + LRR ++
Sbjct: 293 DVN--TGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR--VL 346
Query: 432 LANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVH 491
+ + V +++ + SG DR I W +R L G G I + V
Sbjct: 347 VGHRAAVNVVDFDDKYIVSASG-DRTIKVWSTSTCEFVRTLNGHKRG-IACLQYRDRLV- 403
Query: 492 FVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+G +D+ +++WD G V GH + IR N+ IVS + DG I W
Sbjct: 404 -VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Query: 441 CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHL 500
C ++ +II+ D I W+ ++ L G +GS+ + + + VTG +D
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH-TGSVLCLQYDERVI--VTGSSDST 288
Query: 501 VKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V+VWD N GEV + + H+ + +R S N +V+ S D +I W
Sbjct: 289 VRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 332
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/184 (26%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 250 SFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTC 309
S TD + H AV V F + + + I+VW TS+ E +R N
Sbjct: 336 SATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWSTSTC-EFVRTL--NGHK 390
Query: 310 HGIDFMR-DGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGG 368
GI ++ + ++S +D IR + E G + V+ H V I D KR++SG
Sbjct: 391 RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEG-HEELVRCIRF--DNKRIVSGA 447
Query: 369 GEGEVRVWQIGCQTQKLEEA-------LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 421
+G+++VW + A L EH V R++ + + +++S D T +IWD
Sbjct: 448 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWD 505
Query: 422 LVRL 425
+ +
Sbjct: 506 FLNV 509
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 66.6 bits (161), Expect = 6e-11
Identities = 60/277 (21%), Positives = 118/277 (42%), Gaps = 16/277 (5%)
Query: 282 TCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+ A I++W+ S+ + + +T C F+ + ++ GK++ + +G L+
Sbjct: 432 SAAADSIKIWNRSTLQCIRTMTCEYALCSF--FVPGDRQVVIGTKTGKLQLYDLASGNLL 489
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGC-----QTQKLEEALKEHKS-- 394
I+ AH + +++ + D + ++GG + V+ W TQK ++K+ ++
Sbjct: 490 ETID-AHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQK-RLSVKQTRTLQ 547
Query: 395 ---SVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQCVCYHPEEFQII 450
V C+ N + + D T I+ + L+ + + L C+ + I
Sbjct: 548 LDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIA 607
Query: 451 TSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGE 510
T DR + W + G + L S+ + + F T G DH +K WD ++ E
Sbjct: 608 TGSADRNVKIWGLDFGDCHKSLFAH-DDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
Query: 511 VTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 547
GH I + +SP Y+VS S D ++ W+
Sbjct: 667 HIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/160 (20%), Positives = 74/160 (46%), Gaps = 14/160 (8%)
Query: 352 VTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTA 411
VT + + D + G +G +R++ + + + HK++++ ++ + +
Sbjct: 68 VTCLCPSPDGLHLAVGYEDGSIRIFSL--LSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125
Query: 412 STDGTCIIWDLV------RLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFD 465
S D I+WD++ RL+ ++ + LF E+ ++TSG D + +W++
Sbjct: 126 SKDTDIIVWDVINESGLYRLKGHKDAITQALFL-----REKNLLVTSGKDTMVKWWDLDT 180
Query: 466 GTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWD 505
+ + G + + G+ + E +TG +D ++VWD
Sbjct: 181 QHCFKTMVGHRT-EVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/167 (21%), Positives = 69/167 (41%), Gaps = 2/167 (1%)
Query: 221 LQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELF 280
L+ +T + +G VG E+ I S + + H A+ + + L
Sbjct: 64 LKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLA 123
Query: 281 ATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRL 340
+ DI VW + L R+ F+R+ ++++ D ++ + +T
Sbjct: 124 SGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHC 183
Query: 341 MYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEE 387
+ HR V + S+ KR+I+G + E+RVW I Q++E+
Sbjct: 184 FKTMVG-HRTEVWGLVLLSEEKRLITGASDSELRVWDI-AYLQEIED 228
Score = 37.4 bits (85), Expect = 0.036
Identities = 30/159 (18%), Positives = 63/159 (39%), Gaps = 2/159 (1%)
Query: 393 KSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITS 452
K V+C+ + DG+ I+ L+ N + + + + S
Sbjct: 65 KQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLAS 124
Query: 453 GT-DRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEV 511
G+ D I W+V + + + L+G + + ++ + VT G D +VK WD +
Sbjct: 125 GSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNL-LVTSGKDTMVKWWDLDTQHC 183
Query: 512 THVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPY 550
VGH + + + + +++ ++D + W Y
Sbjct: 184 FKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
Score = 29.3 bits (64), Expect = 9.8
Identities = 17/57 (29%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 18 AVIGFNDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSI 74
AV + +WD + E + L K ++ L SP+ L+L G +DGS+ ++S+
Sbjct: 40 AVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAV--GYEDGSIRIFSL 94
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 66.6 bits (161), Expect = 6e-11
Identities = 61/258 (23%), Positives = 113/258 (43%), Gaps = 17/258 (6%)
Query: 291 WHTSSNRELLRI---TVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 347
W T S + L R+ T P C F DG SA D +R + + + V+
Sbjct: 48 WETRSGQLLWRLGGHTGPVKFCR---FSPDGHLFASASCDCTVRLWDVARAKCLRVLKG- 103
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H+ V ++ + D +++ SGG + V +W + Q+ ++ L H+ S+
Sbjct: 104 HQRSVETVSFSPDSRQLASGGWDKRVMLWDV--QSGQMLRLLVGHRDSIQSSDFSPTVNC 161
Query: 408 CVTASTDGTCIIWDLVRLR---RNQMILANTL-FQCVCYHPEEFQIITSGT-DRKIAYWE 462
T S D T IWDL + +Q + ++ C+CY ++ SG+ D+ I W+
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK 219
Query: 463 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 522
+++ +L+G ++ + + + + + + G +VKVWD N G+ G
Sbjct: 220 PTTSSLLIQLKGHVTW-VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278
Query: 523 TRIRISPGNQYIVSVSAD 540
+P + +VS +AD
Sbjct: 279 HTCAFTPDGKILVSGAAD 296
Score = 52.8 bits (125), Expect = 8e-07
Identities = 55/284 (19%), Positives = 118/284 (41%), Gaps = 17/284 (5%)
Query: 223 GGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVF-PFGTAELFA 281
G + S +G L G+E+ +Y + H V+ F P G A
Sbjct: 22 GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81
Query: 282 TCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLM 341
+C +R+W + + L + + + F D + + S D ++ + ++G+++
Sbjct: 82 SC-DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 342 YVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLE-EALKEHKSSVSCIR 400
++ HR + + + + +G + V +W + T + +AL+ H +++SC+
Sbjct: 141 RLLVG-HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 401 VKRNNEECVTASTDGTCIIWD------LVRLRRNQMILANTLFQCVCYHPEEFQIITSGT 454
+ + S D T IW L++L+ + T + + + P+E + ++G
Sbjct: 200 YSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHV-----TWVKSIAFSPDELWLASAGY 253
Query: 455 DRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
R + W+ G + L+G L + + T +G V+G D
Sbjct: 254 SRMVKVWDCNTGKCLETLKGVLDVA-HTCAFTPDGKILVSGAAD 296
Score = 43.5 bits (101), Expect = 5e-04
Identities = 33/157 (21%), Positives = 63/157 (40%), Gaps = 2/157 (1%)
Query: 391 EHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVC-YHPEEFQI 449
+H V+ + + +T S DG W+ + + +T C + P+
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 450 ITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEG 509
++ D + W+V +R L+G S+ + + + +GG D V +WD G
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 510 EVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
++ + VGH +I SP + + S D + W
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Score = 40.0 bits (92), Expect = 0.006
Identities = 20/73 (27%), Positives = 30/73 (41%)
Query: 474 GSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQY 533
G G +N + +G +TG D V W+ G++ GH+G + R SP
Sbjct: 18 GQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHL 77
Query: 534 IVSVSADGAILRW 546
S S D + W
Sbjct: 78 FASASCDCTVRLW 90
Score = 31.6 bits (70), Expect = 2.0
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 11/96 (11%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
LWD + L L H+ +E ++FSP+ L S G D V++W + +
Sbjct: 89 LWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS--GGWDKRVMLWDVQSGQML------ 140
Query: 87 GLNVGNATNV---IFSRCRDEMFMTAGNGTIRVWEL 119
L VG+ ++ FS + + + + T+ +W+L
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 30.4 bits (67), Expect = 4.4
Identities = 14/38 (36%), Positives = 23/38 (60%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLG 62
I +W LL +L H ++++AFSP++L+L S G
Sbjct: 215 IHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAG 252
Score = 29.6 bits (65), Expect = 7.5
Identities = 15/50 (30%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSI 74
++LWD ++ ++L L H+ I++ FSP L + G D +V +W +
Sbjct: 129 VMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT--GSWDSTVHIWDL 176
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 65.9 bits (159), Expect = 9e-11
Identities = 55/204 (26%), Positives = 88/204 (43%), Gaps = 11/204 (5%)
Query: 347 AHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKR--N 404
AH+ V + T D +++GG + +R++ + K E KE S I+ +
Sbjct: 98 AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLN----KPEAEPKEISGHTSGIKKALWCS 153
Query: 405 NEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPE-EFQIITSGTDRKIAYWEV 463
++ + ++ D T +WD + + + N + Y PE E +IT G R IA+
Sbjct: 154 EDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYG--RSIAFHSA 211
Query: 464 FDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNIT 523
I+ E +IN + E V GG D + +DYN GE GH G I
Sbjct: 212 VSLDPIKSFEAP--ATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIH 269
Query: 524 RIRISPGNQYIVSVSADGAILRWK 547
+R SP + S S DG + W+
Sbjct: 270 CVRFSPDGELYASGSEDGTLRLWQ 293
Score = 38.5 bits (88), Expect = 0.016
Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 181 FSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFLVG 240
F++ VS++ + G +LV + + F + PIK + I S +L E + G
Sbjct: 182 FNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAG 241
Query: 241 TEESHIYRVSFTDFKETLIATCHFDAVEDIVF-PFGTAELFATCAKK-DIRVWHT 293
E+ +Y+ + +E HF + + F P G EL+A+ ++ +R+W T
Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDG--ELYASGSEDGTLRLWQT 294
Score = 37.7 bits (86), Expect = 0.028
Identities = 32/161 (19%), Positives = 69/161 (42%), Gaps = 14/161 (8%)
Query: 286 KDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVIN 345
K +R+W ++ E+ + NM+ ++++ +G+ ++ + R+ A + + I
Sbjct: 164 KTVRLWDHATMTEVKSLNF-NMSVSSMEYIPEGEILVITYG----RSIAFHSAVSLDPIK 218
Query: 346 NAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 405
+ A+ K + GGE + ++++ + + E+ K H + C+R +
Sbjct: 219 SFEAPATINSASLHPEKEFLVAGGE-DFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDG 277
Query: 406 EECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEE 446
E + S DGT +W Q ++ T C PEE
Sbjct: 278 ELYASGSEDGTLRLW--------QTVVGKTYGLWKCVLPEE 310
Score = 33.5 bits (75), Expect = 0.52
Identities = 22/116 (18%), Positives = 52/116 (44%), Gaps = 3/116 (2%)
Query: 392 HKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIIT 451
HK +V + ++ + TA+ D T +WD V + + + V + + ++T
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
Query: 452 SGTDRKIAYWEVFDGTV-IRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDY 506
G D+ + +++ +E+ G SG + +++ + +D V++WD+
Sbjct: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSED--KQILSADDKTVRLWDH 171
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/228 (21%), Positives = 84/228 (36%), Gaps = 4/228 (1%)
Query: 320 SIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIG 379
S+I +D + E I H V + + D ++S +G VR+W +
Sbjct: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL- 572
Query: 380 CQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL-FQ 438
QT K H V + V+ D +W + ++ +
Sbjct: 573 -QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN 631
Query: 439 CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 498
C +HP + T DR + W+V +G +R G G I+ + + G TG D
Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH-KGPIHSLTFSPNGRFLATGATD 690
Query: 499 HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 546
V +WD G + GH+ + +R S + + S S D + W
Sbjct: 691 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 19/99 (19%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAA 86
LWD N + + HKG I +L FSPN +L + G DG V++W I
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLAT--GATDGRVLLWDIGH---------- 700
Query: 87 GLNVGNATNVIFSRC-----RDEMFMTAG--NGTIRVWE 118
GL VG + C RD + +G + T+R+W+
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 38.5 bits (88), Expect = 0.016
Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 9/98 (9%)
Query: 334 APETGRLMYVINN-------AHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLE 386
A T RL V+N H+ + ++ + + + + +G +G V +W IG E
Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706
Query: 387 EALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVR 424
LK H +V +R R+ E + S D T +WD ++
Sbjct: 707 --LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 31.2 bits (69), Expect = 2.6
Identities = 44/203 (21%), Positives = 84/203 (41%), Gaps = 8/203 (3%)
Query: 234 GHQFLVGTEESHIYRVSFTDFKETL-IATCHFDAVEDIVFPFGTAELFATCAKKDIRVWH 292
G+ F+ G + + R+ TD + L I H V F + + A + +R+W
Sbjct: 597 GYYFVSGGHD-RVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 293 TSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV 352
+ + T H + F +G+ + + DG++ + G LM H V
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG-LMVGELKGHTDTV 714
Query: 353 TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECV--T 410
++ + D + + SG + VR+W + LE + ++ I + N++E + T
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE--TDDFTTATGHINLPENSQELLLGT 772
Query: 411 ASTDGTCIIWDLVRLRRNQMILA 433
T T ++ L RRN ++ A
Sbjct: 773 YMTKSTPVV-HLHFTRRNLVLAA 794
Score = 30.8 bits (68), Expect = 3.4
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICG 82
+ D K L L H G + +FSP+ YL+S +DG+V +WS+ + G
Sbjct: 527 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLS--SSEDGTVRLWSLQTFTCLVG 580
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/224 (22%), Positives = 100/224 (44%), Gaps = 15/224 (6%)
Query: 288 IRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNA 347
IR+W + +++ I + + F D + + + + GK+ F E+G+ Y ++
Sbjct: 88 IRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
+ + +IA + D K + SG +G + ++ I T KL L+ H + + +++
Sbjct: 148 GKF-ILSIAYSPDGKYLASGAIDGIINIFDIA--TGKLLHTLEGHAMPIRSLTFSPDSQL 204
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYW 461
VTAS DG I+D+ LA TL V + P++ ++S +D+ + W
Sbjct: 205 LVTASDDGYIKIYDVQHAN-----LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
Query: 462 EVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWD 505
+V T + + G+ G V+ G+D + ++D
Sbjct: 260 DVGTRTCVHTFFDH-QDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 54.7 bits (130), Expect = 2e-07
Identities = 45/209 (21%), Positives = 95/209 (45%), Gaps = 6/209 (2%)
Query: 340 LMYVINNAHRIGVTAIATTSDCKR----VISGGGEGEVRVWQIGCQTQKLEEALKEHKSS 395
+++ AH + ++A ++ K V++G + V+VW+ + L+ +L+ H+
Sbjct: 7 ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 396 VSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTD 455
V + + ++S D +WDL ++ + I A + + Q + +GT
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 456 -RKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHV 514
K+ + V G L+ + I + + +G + +G D ++ ++D G++ H
Sbjct: 127 VGKVNIFGVESGKKEYSLD-TRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185
Query: 515 GVGHSGNITRIRISPGNQYIVSVSADGAI 543
GH+ I + SP +Q +V+ S DG I
Sbjct: 186 LEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
Score = 43.9 bits (102), Expect = 4e-04
Identities = 33/200 (16%), Positives = 81/200 (40%), Gaps = 4/200 (2%)
Query: 348 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEE 407
H++GV ++ + S + +R+W + + K +++ + +++
Sbjct: 63 HQLGVVSVDISHTLPIAASSSLDAHIRLWDL--ENGKQIKSIDAGPVDAWTLAFSPDSQY 120
Query: 408 CVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDG 466
T + G I+ + ++ + F + Y P+ + + D I +++ G
Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
Query: 467 TVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIR 526
++ LEG I + + + VT +D +K++D + GH+ + +
Sbjct: 181 KLLHTLEGHAM-PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVA 239
Query: 527 ISPGNQYIVSVSADGAILRW 546
P + + VS S+D ++ W
Sbjct: 240 FCPDDTHFVSSSSDKSVKVW 259
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAI 80
I ++D ++ L LS H + +AF P+D + VS D SV VW + R +
Sbjct: 214 IKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVS--SSSDKSVKVWDVGTRTCV 267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,515,144
Number of Sequences: 37866
Number of extensions: 955239
Number of successful extensions: 3871
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 1909
Number of HSP's gapped (non-prelim): 1303
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.