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Search of human proteins with 32483416
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo
sapiens]
(1020 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 1964 0.0
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 524 e-148
gi|14249342 internexin neuronal intermediate filament protein, a... 343 5e-94
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 303 4e-82
gi|62414289 vimentin [Homo sapiens] 295 1e-79
gi|55749932 desmin [Homo sapiens] 283 4e-76
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 267 3e-71
gi|21264345 peripherin [Homo sapiens] 266 7e-71
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 266 1e-70
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 218 2e-56
gi|4504919 keratin 8 [Homo sapiens] 195 2e-49
gi|67782365 keratin 7 [Homo sapiens] 186 1e-46
gi|4557701 keratin 17 [Homo sapiens] 182 1e-45
gi|153791158 keratin 75 [Homo sapiens] 178 2e-44
gi|4557699 keratin 12 [Homo sapiens] 177 3e-44
gi|15431310 keratin 14 [Homo sapiens] 174 5e-43
gi|110349719 titin isoform N2-A [Homo sapiens] 172 1e-42
gi|24234699 keratin 19 [Homo sapiens] 172 1e-42
gi|155969697 keratin 6C [Homo sapiens] 171 2e-42
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 171 2e-42
gi|119395754 keratin 5 [Homo sapiens] 171 2e-42
gi|109148552 keratin 3 [Homo sapiens] 171 2e-42
gi|24430190 keratin 15 [Homo sapiens] 171 3e-42
gi|119703753 keratin 6B [Homo sapiens] 171 4e-42
gi|5031839 keratin 6A [Homo sapiens] 170 7e-42
gi|104526627 triadin [Homo sapiens] 170 7e-42
gi|153791670 keratin 76 [Homo sapiens] 169 1e-41
gi|131412225 keratin 13 isoform a [Homo sapiens] 168 3e-41
gi|4504935 keratin 85 [Homo sapiens] 166 1e-40
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 165 2e-40
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 1964 bits (5089), Expect = 0.0
Identities = 1020/1020 (100%), Positives = 1020/1020 (100%)
Query: 1 MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSA 60
MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSA
Sbjct: 1 MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSA 60
Query: 61 SPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEA 120
SPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEA
Sbjct: 61 SPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEA 120
Query: 121 HNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAH 180
HNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAH
Sbjct: 121 HNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAH 180
Query: 181 VRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGE 240
VRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGE
Sbjct: 181 VRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGE 240
Query: 241 LLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRL 300
LLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRL
Sbjct: 241 LLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRL 300
Query: 301 SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360
SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY
Sbjct: 301 SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360
Query: 361 QEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPF 420
QEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPF
Sbjct: 361 QEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPF 420
Query: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE
Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
Query: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
Query: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660
PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA
Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660
Query: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
Query: 781 FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK 840
FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK
Sbjct: 781 FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK 840
Query: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 524 bits (1349), Expect = e-148
Identities = 367/910 (40%), Positives = 525/910 (57%), Gaps = 83/910 (9%)
Query: 37 TRSAAGSSSGFHS--WTRTSVSSVSASPSR--------FRGAGAASSTDSLD-----TLS 81
+R + SSGF S W+R S S+VS+S R + A +S+ SLD +L
Sbjct: 25 SRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLL 84
Query: 82 NGPEGCMVAVATSRS-EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRS 140
NG G SRS EKEQLQ LNDRFAGYI+KV LE N+ +E E ALRQ+QA +
Sbjct: 85 NGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHA 144
Query: 141 AMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAAR 200
+G+ Y++E+RE+R + + + Q++L+ +HL EDI +++R ++EAR R++ EAA R
Sbjct: 145 QLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIR 204
Query: 201 ALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETR 260
AL + +EA +V+L KK Q+LQ+E +LR +H+EEV +LL QIQ S + E +
Sbjct: 205 ALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQAS-----HITVERK 259
Query: 261 DALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITE 320
D LK D+++AL+EIR+QLE H+ Q+ Q+EEWF+ R +L+EAA+ N +A+RSA+EEI E
Sbjct: 260 DYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAE 319
Query: 321 YRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAA 380
YRRQLQ+++ ELE+++ TK+SLERQ S++E+RH D++SYQ+ IQQL+ ELR TKWEMA
Sbjct: 320 YRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMAR 379
Query: 381 QLREYQDLLNVKMALDIEIAAYRKLLEGEECRIG------FGPI-----PFSLPEGLPKI 429
LREYQDLLNVKMALDIEIAAYRKLLEGEE R GP+ P ++ + K
Sbjct: 380 HLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKP 439
Query: 430 PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVT---EEEEKEAKEEEGKEE 486
+ +KV+ + +++E+++ E E + T +TEE+ +EE+KEA EE+ +E
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499
Query: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS 546
E EEE A + P + EKE + +EE + AKS + EE S E S
Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559
Query: 547 PEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA-KEEAKSPAEAKSPEKA- 604
+ + +EE ++ EA E EEA++ E K EK++ A KEE + A+ + PEKA
Sbjct: 560 --EKEEGEQEEGETEAEA---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 614
Query: 605 ----KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660
KSPV+E+ KSP KSPV+E+ KSP KSP +E+ KSP KSP +E+
Sbjct: 615 SPVPKSPVEEKGKSPV-PKSPVEEKGKSPV-------PKSPVEEKGKSP-VPKSPVEEKG 665
Query: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
KSP +KSPV+ +AKSP KSPV+ EAKS + ++E + E ++P +E+ + E
Sbjct: 666 KSP-VSKSPVEEKAKSP-VPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKE 722
Query: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
+ V E+ +KA+SPVKEEA + + L+ ++ E P ++E K
Sbjct: 723 EKPKDVPEK----KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE------K 772
Query: 781 FPEKAKSP-VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK----- 834
EKA EE S + AK KED A E+ KEEV+ KE+ +E +
Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVT 831
Query: 835 -------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKKEPAVEKPK 886
E + E+ KT EK S+ + K K V +K E E +
Sbjct: 832 NGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFE 891
Query: 887 ESKVEAKKEE 896
E V KK E
Sbjct: 892 EKLVSTKKVE 901
Score = 164 bits (416), Expect = 3e-40
Identities = 208/830 (25%), Positives = 345/830 (41%), Gaps = 90/830 (10%)
Query: 212 ARVDLQKKAQALQEE-CGYLRRHH--QEEVGELLGQIQGSGAAQAQMQAETRDALKCDVT 268
+R + +++ Q L + GY+ + H +++ E+ +IQ QA A+ DA ++
Sbjct: 97 SRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQAS-HAQLGDAYDQEI- 154
Query: 269 SALREIRAQLE--GHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQ 326
RE+RA LE H + + RL E + + I R+ ++
Sbjct: 155 ---RELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIE 211
Query: 327 ARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ----------LDAELRNTKW 376
+ L SL+ + + L H+ ++A IQ L ++
Sbjct: 212 EASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALK 271
Query: 377 EMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHI 436
E+ +QL + D N+ A + Y KL E E I
Sbjct: 272 EIRSQLESHSDQ-NMHQAEEWFKCRYAKLTEAAEQN--------------------KEAI 310
Query: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE--EEA 494
+ EE + + + +++ + E + T+E E + + +E + ++ ++
Sbjct: 311 RSAKEEIAEYRRQLQSKSI----ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQL 366
Query: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
E TK A + + + + A K E EE + S
Sbjct: 367 ENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTH 426
Query: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
+ + + P+ E K + K E+ EE K E E+A + + EE
Sbjct: 427 RPPITISSKIQKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAITEELAV 482
Query: 615 PAEAKSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
+KEE K AE K E +A+ KSP KA +PE +E + ++ + + E
Sbjct: 483 S------MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 536
Query: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
+ E AKS +AE EK S KEE E+ + + EA+ E + KEE K
Sbjct: 537 EEEDEGAKSD-QAEEGGSEKEGSSEKEEG---EQEEGETEAEAEGEE---AEAKEEKKVE 589
Query: 734 EKAKS-PVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
EK++ KEE + K + PEKAK SP K+P +E+ +SP K SPV+E+
Sbjct: 590 EKSEEVATKEELVADAKVEKPEKAK-----SPVPKSPVEEKGKSPVPK------SPVEEK 638
Query: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852
KSP KSP++E K+P + P +E+ KSPV + P E K K P K+ E+A + +
Sbjct: 639 GKSPVP-KSPVEEKGKSPVPKSPVEEKGKSPV--SKSPVEEKAKSPVPKSPVEEAKSKAE 695
Query: 853 TEEKKDSKKEEAPKKEAPK-PKVEEKKEPAVEKPKESKVEAK-KEEAEDKKKVPTPEKEA 910
+ + ++EE KEAPK KVE+K+E + P++ K E+ KEEA + T +
Sbjct: 696 VGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV 755
Query: 911 PAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK 970
+ E KE+ KP ++ +KE + A + S+ + A K KE+ A E + K
Sbjct: 756 HLEKETKEEGKPLQQ----EKEKEKAGGEGGSEEEGSDKGA--KGSRKEDIAVNGEVEGK 809
Query: 971 TEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQK--DSKPPEKATEDKAAK 1018
E + + +K +E K S D+K K EK K +
Sbjct: 810 EEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 859
Score = 119 bits (298), Expect = 1e-26
Identities = 186/743 (25%), Positives = 303/743 (40%), Gaps = 95/743 (12%)
Query: 327 ARTTELEALKSTKDS----------LERQRSELEDRHQA---DIASYQEAIQQLDAELRN 373
+R+ E E L+ D LE+Q E+E QA AS+ + D E+R
Sbjct: 97 SRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRE 156
Query: 374 TKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVS 433
+ + E + L+ +I ++ E EE R+ + L K +
Sbjct: 157 LRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFE-EEARLRDDTE--AAIRALRKDIEEA 213
Query: 434 THIKVKSEEKIKVVEKS--------EKETVIVEEQTEETQVTEE---VTEEEEKEAKEEE 482
+ +KV+ ++K++ ++ E+E + Q + + +T E + + A +E
Sbjct: 214 SLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEI 273
Query: 483 GKEEEGGEEEEAEGGEEETKSPPAE--EAASPEKEAKSPVKEEA---KSPAEAKSPEKEE 537
+ E ++ EE K A+ EAA KEA KEE + ++KS E E
Sbjct: 274 RSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELES 333
Query: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE----AK 593
+ E S E+ S +E + ++ ++ E A+ + + K
Sbjct: 334 VRGTKE--SLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVK 391
Query: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
+ + K EE + A S + K + P E K + K
Sbjct: 392 MALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHK 451
Query: 654 SPEK--EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK--SPEKAKSPVKEEA-----KS 704
E+ EE K ++ +A E+ +K E K + EK + P EE KS
Sbjct: 452 FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKS 511
Query: 705 PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764
P KA +P +E + ++ + +EE + E AKS EE S ++ S
Sbjct: 512 PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS------------ 559
Query: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
E + +EE + A+ E+A++ KEE K EK++ ++ + ++ K E+ KSPV
Sbjct: 560 EKEEGEQEEGETEAEAEGEEAEA--KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 617
Query: 825 KEEEKPQEVKVKEP-PKKAEEEKAPA-TPKTEEKKDSKKEEAPKKEAPKPKVEEK----- 877
+ P E K K P PK EEK + PK S EE K PK VEEK
Sbjct: 618 PKS--PVEEKGKSPVPKSPVEEKGKSPVPK------SPVEEKGKSPVPKSPVEEKGKSPV 669
Query: 878 -KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936
K P EK K ++ EEA+ K +V E++ + EVKE K +EK E +++P D
Sbjct: 670 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK-EEKVEKKEEKPKDV 728
Query: 937 KAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK 996
K+ ++ K+EA E + K E + KE+ K L +E K EKA
Sbjct: 729 PEKKKAESPVKEEAVAEVVTITKSV------KVHLEKETKEEGKPLQQEKEK---EKAGG 779
Query: 997 SSSTDQKDSKPPEKATEDKAAKG 1019
++++ S DK AKG
Sbjct: 780 EGGSEEEGS--------DKGAKG 794
Score = 98.2 bits (243), Expect = 3e-20
Identities = 161/704 (22%), Positives = 272/704 (38%), Gaps = 91/704 (12%)
Query: 336 KSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMAL 395
K ++ + + Q L DR A Y E + L+ + + + E+ A ++ + A
Sbjct: 95 KLSRSNEKEQLQGLNDR----FAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAY 150
Query: 396 DIEIAAYRKLLE---GEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEK 452
D EI R LE E+ ++ L E + ++ K + EE+ ++ + +E
Sbjct: 151 DQEIRELRATLEMVNHEKAQVQLDSD--HLEEDIHRL-------KERFEEEARLRDDTEA 201
Query: 453 ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP 512
+ + EE + + +++ + ++E EEE A+ + S E
Sbjct: 202 AIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDY 261
Query: 513 EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA 572
K S +E +S E+ S + E AK E A+ EA KEE
Sbjct: 262 LKTDISTALKEIRSQLESHSDQNMHQAE--EWFKCRYAK--LTEAAEQNKEAIRSAKEEI 317
Query: 573 KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEV 632
AE + ++KS E + E S E+ S ++E + ++ ++
Sbjct: 318 ---AEYRRQLQSKSIELESVRGTKE--SLERQLSDIEERHNHDLSSYQDTIQQLENELRG 372
Query: 633 KSPEKAKSPTK-EEAKSPEKAKSPE----KEEAKSPEKAKSPVKAEAKSPEKAKSP---V 684
E A+ + ++ + + A E ++ + E S P P +
Sbjct: 373 TKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITI 432
Query: 685 KAEAKSPEKAKSPVKEEAKSPEKA--KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
++ + P+ +K + K E+ ++ V++E E+A + + EE +KE
Sbjct: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVS------MKE 486
Query: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP-VKEEVKSPEKAKS 801
E K + K E P EE A K P KA +P VKEE E+ +
Sbjct: 487 EKKEAAEEKEEE--------------PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEG 532
Query: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
+E+ + + + EE S + + +E + +E +AE E A K E+K + K
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592
Query: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
EE KE E + VEKP+++K K E+K K P P
Sbjct: 593 EEVATKE------ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP--------------- 631
Query: 922 PKEKTEVAKKEPDDAKAKE--PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979
K P + K K P P E+K +P K EEK K P K E KAK
Sbjct: 632 ---------KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 682
Query: 980 KTLSKEPSKPKAEKAE-KSSSTDQKDSK--PPEKATEDKAAKGK 1020
E +K KAE + + ++K+ K P E+ E K K K
Sbjct: 683 PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 726
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 343 bits (880), Expect = 5e-94
Identities = 215/495 (43%), Positives = 299/495 (60%), Gaps = 24/495 (4%)
Query: 2 MSFGGADALLGAP-FAPLHGGGS-LHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVS 59
MSFG L + + + G GS L L+ GGAGG RS + S S S S +S
Sbjct: 1 MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSL 60
Query: 60 ASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLE 119
+R A+ D + E ++ +EKEQLQ LNDRFA +I+KV QLE
Sbjct: 61 GLGLAYRRPPASDGLDLSQAAARTNEYKIIRT----NEKEQLQGLNDRFAVFIEKVHQLE 116
Query: 120 AHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIA 179
NR+LE E AALRQ+ A S +GEL++RE+R++R + +AR Q LE++ L E++
Sbjct: 117 TQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQ 176
Query: 180 HVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVG 239
+R R ++E+R RE AE A +A R A AR+DL+KK ++L +E ++R+ H EEV
Sbjct: 177 RLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVA 236
Query: 240 ELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDR 299
ELL +Q S A A++ K D+TSALREIRAQ E A ++ +EEW++ +
Sbjct: 237 ELLATLQASSQAAAEVDVTVA---KPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFAN 293
Query: 300 LSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIAS 359
L+E A +T+A+R+++EEI EYRRQLQART E+E L+ +SLERQ ELE+RH A++A
Sbjct: 294 LNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAG 353
Query: 360 YQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRI------ 413
YQ++I QL+ +LRNTK EMA LREYQDLLNVKMALDIEIAAYRKLLEGEE R
Sbjct: 354 YQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLS 413
Query: 414 --GFGPIP---FSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEET-QVT 467
G P+P + LP P+I S +T + +K E+ E+ + + ++T + +
Sbjct: 414 ISGLNPLPNPSYLLP---PRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESF 470
Query: 468 EEVTEEEEKEAKEEE 482
EE+ EE K+ E
Sbjct: 471 EEILEETVISTKKTE 485
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 303 bits (777), Expect = 4e-82
Identities = 202/521 (38%), Positives = 301/521 (57%), Gaps = 28/521 (5%)
Query: 48 HSWTRTSVSSVSASPSR---FRGAGAASSTDSLDTLSNGPEGCMVAVATS-----RSEKE 99
+S R++ SS SA S R + ++SS + +L N + A++ EK
Sbjct: 33 YSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKA 92
Query: 100 QLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLR 159
QLQ LNDRFA +I++V +LE N+ LE E LRQ+ + S LYE+E+R++R A
Sbjct: 93 QLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAED 152
Query: 160 LGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKK 219
+ L+ E+E L E + +++ R ++E RE+AE + A EA AR +L+K+
Sbjct: 153 ATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKR 212
Query: 220 AQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLE 279
+L +E +L++ H+EE+ EL QIQ AQ+ E D K D+++AL++IRAQ E
Sbjct: 213 IDSLMDEISFLKKVHEEEIAELQAQIQ-----YAQISVEM-DVTKPDLSAALKDIRAQYE 266
Query: 280 GHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTK 339
A ++ +EEWF+ R L+E+A NTDA+R+A++E++E RR L+A+T E+EA +
Sbjct: 267 KLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMN 326
Query: 340 DSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEI 399
++LE+Q ELED+ ADI++ Q+ I +L+ ELR TK EMA L+EYQDLLNVKMALDIEI
Sbjct: 327 EALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEI 386
Query: 400 AAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSV---STHIKVKSEEKIKVVEKSEKETVI 456
AAYRKLLEGEE R+ F + S+ G + V S + +++ + + +S
Sbjct: 387 AAYRKLLEGEETRLSFTSVG-SITSGYSQSSQVFGRSAYGGLQTSSYL-MSTRSFPSYYT 444
Query: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516
Q E+ +V E + + +EAK+E E GE EE E +EE + EE A+ E+EA
Sbjct: 445 SHVQEEQIEVEETIEAAKAEEAKDEPPSE---GEAEEEEKDKEEAE----EEEAAEEEEA 497
Query: 517 KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
EEAK E + E EE + E + EK A EE
Sbjct: 498 AKEESEEAKE--EEEGGEGEEGEETKEAEEEEKKVEGAGEE 536
Score = 48.1 bits (113), Expect = 4e-05
Identities = 97/492 (19%), Positives = 198/492 (40%), Gaps = 37/492 (7%)
Query: 426 LPKIPSVSTHIK-VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484
L ++ ++S +K ++++EK ++ + +++ +E + E + +V E E +++ +
Sbjct: 73 LSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIE-RVHELEQQNKVLEAELLVLRQKHSE 131
Query: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
E E + A E A+ EK+A +E + EE EV
Sbjct: 132 PSRFRALYEQEIRDLRL----AAEDATNEKQALQGEREGLEETLRNLQARYEE-----EV 182
Query: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604
S E A+ E K EA E K + EE + +A+ + A
Sbjct: 183 LSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQI-QYA 241
Query: 605 KSPVKEEAKSP--AEAKSPVKEEAKSPAEVKSPEKAKSPTKEE--AKSPEKAKSPEKEEA 660
+ V+ + P + A ++ + + A K+ + A+ K + AK+ + A
Sbjct: 242 QISVEMDVTKPDLSAALKDIRAQYEKLA-AKNMQNAEEWFKSRFTVLTESAAKNTDAVRA 300
Query: 661 KSPEKAKSP--VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
E ++S +KA+ E + +A K ++ + + + + + ++ E ++
Sbjct: 301 AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT 360
Query: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778
+ + +E + K + E + K E+ + L S + T ++ +
Sbjct: 361 TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETR-LSFTSVGSITSGYSQS---S 416
Query: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
F A ++ P + E++I +E +++ EE K EP
Sbjct: 417 QVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKD------EP 470
Query: 839 PKKAE-EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK-------KEPAVEKPKESKV 890
P + E EE+ + EE++ +++EEA K+E+ + K EE+ +E + +E KV
Sbjct: 471 PSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKV 530
Query: 891 EAKKEEAEDKKK 902
E EE KKK
Sbjct: 531 EGAGEEQAAKKK 542
Score = 47.0 bits (110), Expect = 9e-05
Identities = 78/422 (18%), Positives = 166/422 (39%), Gaps = 38/422 (9%)
Query: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE-----EAKSPAEVKSPE 636
+K P++ A E + A E ++ + ++E +A+ EV S E
Sbjct: 127 QKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSRE 186
Query: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696
A+ E K ++A E K + + K E+ + ++A+ + A+
Sbjct: 187 DAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQI---QYAQI 243
Query: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE--AKSPEKAKSPE 754
V+ + P+ + + +K+ EK + + A+ K++ V E AK+ + ++ +
Sbjct: 244 SVEMDVTKPDLSAA-LKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAK 302
Query: 755 ----------KAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
KAKTL++++ A E+ + S +++ + E K
Sbjct: 303 DEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTK 362
Query: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA 864
+ KE VK + ++++ K E E+ + + S ++
Sbjct: 363 SEMARYLKEYQDLLNVKMAL-------DIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS 415
Query: 865 PKK---------EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915
+ + + + P+ + + + EE + K + E P++ E
Sbjct: 416 SQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGE 475
Query: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
+E+ K KE+ E + ++ AKE S+ A+++E E ++ +E K + EEK K E
Sbjct: 476 AEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEK-KVEGAG 534
Query: 976 KE 977
+E
Sbjct: 535 EE 536
Score = 44.3 bits (103), Expect = 6e-04
Identities = 32/104 (30%), Positives = 58/104 (55%), Gaps = 10/104 (9%)
Query: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976
+E + +E E AK E +AK + PS+ E +E +K++ +EE+A + EE AK
Sbjct: 449 EEQIEVEETIEAAKAE--EAKDEPPSE-GEAEEEEKDKEEAEEEEAAEEEEA------AK 499
Query: 977 EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
E+ + +E + E+ E++ ++++ K E A E++AAK K
Sbjct: 500 EESEEAKEEEEGGEGEEGEETKEAEEEEKKV-EGAGEEQAAKKK 542
Score = 44.3 bits (103), Expect = 6e-04
Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 5/95 (5%)
Query: 913 KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP---AEKKEAAPEKKDTKEEKAKKPEEKP 969
++EV+E + + E + P + +A+E K AE++EAA E++ KEE + EE+
Sbjct: 451 QIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEE 510
Query: 970 KTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004
E +E ++T E + K E A + + +KD
Sbjct: 511 GGE--GEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 43.9 bits (102), Expect = 8e-04
Identities = 90/458 (19%), Positives = 173/458 (37%), Gaps = 37/458 (8%)
Query: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAK--EEEGKEEEGGEEEEAEGGE 498
E++ KV+E E +++ ++ E + E+E ++ + E+ E+ + E EG E
Sbjct: 112 EQQNKVLEA---ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLE 168
Query: 499 EETKSPPA--EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556
E ++ A EE ++A+ + E K EA E K + E
Sbjct: 169 ETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHE 228
Query: 557 EAKSPPEAK------SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
E + +A+ S E + K + K AK+ A+ K++ V
Sbjct: 229 EEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLT 288
Query: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
E S A+ V+ +E + KAK+ E + +A + +E + + A
Sbjct: 289 E--SAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNA---- 342
Query: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730
+ + + + ++ E ++ + + +E + K + E + K EE
Sbjct: 343 --DISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEG--EET 398
Query: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
+ + + + L S T + FP S V+
Sbjct: 399 RLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRS----------FPSYYTSHVQ 448
Query: 791 EE-VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA 849
EE ++ E ++ E+AK E P + E + K++E+ +E + E + A+EE A
Sbjct: 449 EEQIEVEETIEAAKAEEAK---DEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEA 505
Query: 850 TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
+ E + + EE + E + KVE E K K+
Sbjct: 506 KEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 40.8 bits (94), Expect = 0.007
Identities = 30/96 (31%), Positives = 54/96 (56%), Gaps = 6/96 (6%)
Query: 873 KVEEKKEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931
+VEE E A K +E+K E E EAE+++K ++EA + +E+ KE++E AK+
Sbjct: 453 EVEETIEAA--KAEEAKDEPPSEGEAEEEEK---DKEEAEEEEAAEEEEAAKEESEEAKE 507
Query: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967
E + + +E + E +E + + EE+A K ++
Sbjct: 508 EEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 40.0 bits (92), Expect = 0.011
Identities = 24/100 (24%), Positives = 50/100 (50%)
Query: 850 TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE 909
T +E++ +E +A + K E E E+ ++ K EA++EEA ++++ E E
Sbjct: 444 TSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESE 503
Query: 910 APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949
+ E + + E+T+ A++E + + A+KK+
Sbjct: 504 EAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 38.9 bits (89), Expect = 0.025
Identities = 121/600 (20%), Positives = 223/600 (37%), Gaps = 109/600 (18%)
Query: 299 RLSEAAKVNTDAMRS----AQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQ 354
R E +V+ ++RS A+ + Y + + + + S+ SL L+
Sbjct: 17 RYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQV 76
Query: 355 ADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIG 414
A I++ +L++ + + AQL++ D + E+ K+LE E
Sbjct: 77 AAISN----------DLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLV-- 124
Query: 415 FGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474
L + S + + E++I+ + + E+ T E Q + E
Sbjct: 125 -----------LRQKHSEPSRFRALYEQEIRDLR------LAAEDATNEKQALQGEREGL 167
Query: 475 EKEAKEEEGK-EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
E+ + + + EEE E+AEG E + A+EAA E + + + K
Sbjct: 168 EETLRNLQARYEEEVLSREDAEGRLMEARKG-ADEAALARAELEKRIDSLMDEISFLKKV 226
Query: 534 EKEE----------AKSPAEVKSPEKAKSPAKEEAKSPPE---AKSPEKEEA--KSPAEV 578
+EE A+ E+ + S A ++ ++ E AK+ + E KS V
Sbjct: 227 HEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTV 286
Query: 579 KSPEKAKSP-----AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA--KSPVKEEAKSPAE 631
+ AK+ AK+E +E++ KAK+ E + EA K + E K A+
Sbjct: 287 LTESAAKNTDAVRAAKDEV---SESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNAD 343
Query: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK---------AKS 682
+ + + + + E ++ + + +E + K + E + K + +
Sbjct: 344 ISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFT 403
Query: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
V + ++ A + S + P S V+EE E+
Sbjct: 404 SVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETI----- 458
Query: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
EA E+AK + P + E + EK K
Sbjct: 459 EAAKAEEAKD---------------------------------EPPSEGEAEEEEKDKEE 485
Query: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
+E+ A E+E K+E ++ KEEE+ E + E K+AEEE+ EE+ KK+
Sbjct: 486 AEEEEAAEEEEAAKEESEEA--KEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 295 bits (756), Expect = 1e-79
Identities = 169/384 (44%), Positives = 251/384 (65%), Gaps = 20/384 (5%)
Query: 93 TSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVRE 152
T +EK +LQ LNDRFA YIDKVR LE N+ L E L+ Q G+S +G+LYE E+RE
Sbjct: 99 TRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQ--GKSRLGDLYEEEMRE 156
Query: 153 MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAA 212
+R V +L + ++ +E+++L EDI +R++L +E QREEAE ++ + A A
Sbjct: 157 LRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLA 216
Query: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
R+DL++K ++LQEE +L++ H+EE+ EL QIQ + +Q + D K D+T+ALR
Sbjct: 217 RLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQ-----EQHVQIDV-DVSKPDLTAALR 270
Query: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
++R Q E A ++ ++EEW++ + LSEAA N DA+R A++E TEYRRQ+Q+ T E+
Sbjct: 271 DVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEV 330
Query: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
+ALK T +SLERQ E+E+ + A+YQ+ I +L E++N K EMA LREYQDLLNVK
Sbjct: 331 DALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVK 390
Query: 393 MALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEK 452
MALDIEIA YRKLLEGEE RI SLP LP S+ +++ + + + +V+ K
Sbjct: 391 MALDIEIATYRKLLEGEESRI-------SLP--LPNFSSL--NLRETNLDSLPLVDTHSK 439
Query: 453 ETVIVEE-QTEETQVTEEVTEEEE 475
T++++ +T + QV E ++ +
Sbjct: 440 RTLLIKTVETRDGQVINETSQHHD 463
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 283 bits (725), Expect = 4e-76
Identities = 192/484 (39%), Positives = 273/484 (56%), Gaps = 47/484 (9%)
Query: 3 SFGGADAL-----LGAPFAPLHGGGSLH---------YALAR-KGGAGGTRSAAGSSSGF 47
+FGGA L +P P G GS Y ++R GGAGG S S G
Sbjct: 17 TFGGAPGFPLGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGGLGSLRASRLGT 76
Query: 48 HSWTRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDR 107
TRT PS + GAG D ++ + T +EK +LQ LNDR
Sbjct: 77 ---TRT--------PSSY-GAGELLDFSLADAVNQE------FLTTRTNEKVELQELNDR 118
Query: 108 FAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQL 167
FA YI+KVR LE N +L E L+ ++ R A ELYE E+RE+R V L R ++
Sbjct: 119 FANYIEKVRFLEQQNAALAAEVNRLKGREPTRVA--ELYEEELRELRRQVEVLTNQRARV 176
Query: 168 RLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEEC 227
+E+++LL+D+ ++ +L +E + +EEAE A A AR+DL+++ ++L EE
Sbjct: 177 DVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEI 236
Query: 228 GYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTL 287
+L++ H+EE+ EL Q+Q + Q+Q E D K D+T+ALR+IRAQ E A ++
Sbjct: 237 AFLKKVHEEEIRELQAQLQ-----EQQVQVEM-DMSKPDLTAALRDIRAQYETIAAKNIS 290
Query: 288 QSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRS 347
++EEW++ ++ L++AA N DA+R A++E+ EYR Q+Q+ T E++ALK T DSL RQ
Sbjct: 291 EAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMR 350
Query: 348 ELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLE 407
ELEDR ++ + YQ+ I +L+ E+R+ K EMA LREYQDLLNVKMALD+EIA YRKLLE
Sbjct: 351 ELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLE 410
Query: 408 GEECRIGFGPIPFSLPEGLPKIPSV-STHIKVKSEEKIKVVEKSEKETVIVEEQTEETQV 466
GEE RI +S P + + K IK +E + E V +E TQ
Sbjct: 411 GEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVV-----SEATQQ 465
Query: 467 TEEV 470
EV
Sbjct: 466 QHEV 469
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 267 bits (683), Expect = 3e-71
Identities = 167/377 (44%), Positives = 237/377 (62%), Gaps = 13/377 (3%)
Query: 93 TSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVRE 152
T SE+ ++ LNDRFA YI+KVR LE N++L E LR ++ + A ++Y+ E+RE
Sbjct: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLA--DVYQAELRE 122
Query: 153 MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAA 212
+R + +L A +L +E+++L +D+A VRQ+L DE R EAE A + A EA A
Sbjct: 123 LRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLA 182
Query: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
R+DL++K ++L+EE +LR+ H+EEV EL Q+ A+ Q+ E D K D+T+AL+
Sbjct: 183 RLDLERKIESLEEEIRFLRKIHEEEVRELQEQL-----ARQQVHVEL-DVAKPDLTAALK 236
Query: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
EIR Q E A + ++EEW+R + L++AA N + +R A+ E +YRRQLQ+ T +L
Sbjct: 237 EIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDL 296
Query: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
E+L+ T +SLERQ E E+RH + ASYQEA+ +L+ E ++ K EMA L+EYQDLLNVK
Sbjct: 297 ESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVK 356
Query: 393 MALDIEIAAYRKLLEGEECRIGFGPIPFS---LPEGLPKIPSVSTHIKVKSEEKIKVVEK 449
+ALDIEIA YRKLLEGEE RI FS + E SVS +K +K VE
Sbjct: 357 LALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEG-HLKRNIVVKTVEM 415
Query: 450 SEKETVIVEEQTEETQV 466
+ E VI E + E V
Sbjct: 416 RDGE-VIKESKQEHKDV 431
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 266 bits (680), Expect = 7e-71
Identities = 155/390 (39%), Positives = 245/390 (62%), Gaps = 19/390 (4%)
Query: 91 VATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREV 150
+AT +EK++LQ LNDRFA +I+KVR LE N +L GE + R Q+ R+ +L ++E+
Sbjct: 91 LATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARA--DQLCQQEL 148
Query: 151 REMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAE 210
RE+R + LG R ++++E++ L ED+A ++QRL++E R+RE+AE + +A
Sbjct: 149 RELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDAT 208
Query: 211 AARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSA 270
+R++L++K ++L +E +L++ H+EE+ +L Q S +Q Q E +K ++T+A
Sbjct: 209 LSRLELERKIESLMDEIEFLKKLHEEELRDL----QVSVESQQVQQVEVEATVKPELTAA 264
Query: 271 LREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTT 330
LR+IRAQ E A ++ ++EEW++ + LS+AA N +A+R A++E+ E RRQ+Q+ T
Sbjct: 265 LRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTC 324
Query: 331 ELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLN 390
E++ L+ T ++L RQ ELE++ + YQ +L+ ELR K EMA LREYQ+LLN
Sbjct: 325 EVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLN 384
Query: 391 VKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKS 450
VKMALDIEIA YRKLLEGEE RI +P S +IK E +
Sbjct: 385 VKMALDIEIATYRKLLEGEESRI-----------SVPVHSFASLNIKTTVPEVEPPQDSH 433
Query: 451 EKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
++TV++ +T ET+ E VTE ++++ E
Sbjct: 434 SRKTVLI--KTIETRNGEVVTESQKEQRSE 461
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 266 bits (679), Expect = 1e-70
Identities = 151/321 (47%), Positives = 216/321 (67%), Gaps = 8/321 (2%)
Query: 93 TSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVRE 152
T SE+ ++ LNDRFA YI+KVR LE N++L E LR ++ + A ++Y+ E+RE
Sbjct: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLA--DVYQAELRE 122
Query: 153 MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAA 212
+R + +L A +L +E+++L +D+A VRQ+L DE R EAE A + A EA A
Sbjct: 123 LRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLA 182
Query: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
R+DL++K ++L+EE +LR+ H+EEV EL Q+ A+ Q+ E D K D+T+AL+
Sbjct: 183 RLDLERKIESLEEEIRFLRKIHEEEVRELQEQL-----ARQQVHVEL-DVAKPDLTAALK 236
Query: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
EIR Q E A + ++EEW+R + L++AA N + +R A+ E +YRRQLQ+ T +L
Sbjct: 237 EIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDL 296
Query: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
E+L+ T +SLERQ E E+RH + ASYQEA+ +L+ E ++ K EMA L+EYQDLLNVK
Sbjct: 297 ESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVK 356
Query: 393 MALDIEIAAYRKLLEGEECRI 413
+ALDIEIA YRKLLEGEE RI
Sbjct: 357 LALDIEIATYRKLLEGEENRI 377
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 218 bits (556), Expect = 2e-56
Identities = 198/553 (35%), Positives = 281/553 (50%), Gaps = 62/553 (11%)
Query: 378 MAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGF------GPI-----PFSLPEGL 426
MA LREYQDLLNVKMALDIEIAAYRKLLEGEE R GP+ P ++ +
Sbjct: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
Query: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVT---EEEEKEAKEEEG 483
K + +KV+ + +++E+++ E E + T +TEE+ +EE+KEA EE+
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
+E E EEE A + P + EKE + +EE + AKS + EE S E
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
Query: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA-KEEAKSPAEAKSPE 602
S ++ +EE ++ EA E EEA++ E K EK++ A KEE + A+ + PE
Sbjct: 181 GSSEKEEGE--QEEGETEAEA---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 603 KAKSPV-----KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
KAKSPV +E+ KSP KSPV+E+ KSP KSP +E+ KSP KSP +
Sbjct: 236 KAKSPVPKSPVEEKGKSPVP-KSPVEEKGKSPV-------PKSPVEEKGKSP-VPKSPVE 286
Query: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
E+ KSP +KSPV+ +AKSP KSPV+ EAKS + ++E + E ++P +E+ +
Sbjct: 287 EKGKSP-VSKSPVEEKAKSP-VPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
Query: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
E+ V E+ +KA+SPVKEEA + + L+ ++ E P ++E
Sbjct: 344 KKEEKPKDVPEK----KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE---- 395
Query: 778 ADKFPEKAKSP-VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK-- 834
K EKA EE S + AK KED A E+ KEEV+ KE+ +E +
Sbjct: 396 --KEKEKAGGEGGSEEEGSDKGAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKG 452
Query: 835 ----------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKKEPAVE 883
E + E+ KT EK S+ + K K V +K E E
Sbjct: 453 VVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEE 512
Query: 884 KPKESKVEAKKEE 896
+E V KK E
Sbjct: 513 TFEEKLVSTKKVE 525
Score = 163 bits (413), Expect = 7e-40
Identities = 175/538 (32%), Positives = 245/538 (45%), Gaps = 50/538 (9%)
Query: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA--KSPA 554
GEE S A P + P+ +K + P+ E K + K E+ ++
Sbjct: 31 GEETRFSTFAGSITGPLYTHRPPITISSK----IQKPKVEAPKLKVQHKFVEEIIEETKV 86
Query: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEKAKSPVKEEAK 613
++E EA + EE V E+ K A+E+ + P AE + KSPVK A
Sbjct: 87 EDEKSEMEEALTAITEELA----VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
Query: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
E + +EE E + E AKS EE S EK S EKEE + E+ ++ +AE
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS-EKEGSSEKEEGEQ-EEGETEAEAE 200
Query: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
+ E AK K E KS E A KEE + K + P E+AKSP KSPV+E+ K+P
Sbjct: 201 GEEAE-AKEEKKVEEKSEEVA---TKEELVADAKVEKP--EKAKSPVP-KSPVEEKGKSP 253
Query: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP--EKAKSPVK- 790
KSPV+E+ KSP KSP + K KSP K+P +E+ +SP K P EKAKSPV
Sbjct: 254 VP-KSPVEEKGKSP-VPKSPVEEKG---KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 308
Query: 791 ---EEVKS-PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
EE KS E K KE+ + KE PK+E+V+ K+EEKP++V K+ + +E+
Sbjct: 309 SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE---KKEEKPKDVPEKKKAESPVKEE 365
Query: 847 APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906
A A T K E KE KP +EK EK K +EE DK +
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEK-----EKEKAGGEGGSEEEGSDKGAKGSR 420
Query: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP--EKK--DTKEEK- 961
+++ + V + + KE+ E KE + +E + +P EKK D EEK
Sbjct: 421 KED----IAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
Query: 962 -AKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
K EK +E K E+ E++ +K EK T K
Sbjct: 477 VVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534
Score = 113 bits (283), Expect = 8e-25
Identities = 124/412 (30%), Positives = 187/412 (45%), Gaps = 59/412 (14%)
Query: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675
++ + P E K + K E+ TK E EK++ E A + E A S + + +
Sbjct: 58 SKIQKPKVEAPKLKVQHKFVEEIIEETKVE---DEKSEMEEALTAITEELAVSMKEEKKE 114
Query: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735
+ E+ + +AE + KSPVK A +PE VKEE E+ + +EE + E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVK--ATAPE-----VKEEEGEKEEEEGQ-EEEEEEDEG 166
Query: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKS 795
AKS EE S ++ S E + +EE + A+ E+A++ KEE K
Sbjct: 167 AKSDQAEEGGSEKEGSS------------EKEEGEQEEGETEAEAEGEEAEA--KEEKKV 212
Query: 796 PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP-PKKAEEEKAPA-TPKT 853
EK++ ++ + ++ K E+ KSPV + P E K K P PK EEK + PK
Sbjct: 213 EEKSEEVATKEELVADAKVEKPEKAKSPVPKS--PVEEKGKSPVPKSPVEEKGKSPVPK- 269
Query: 854 EEKKDSKKEEAPKKEAPKPKVEEK------KEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
S EE K PK VEEK K P EK K ++ EEA+ K +V E
Sbjct: 270 -----SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 324
Query: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967
++ + EVKE K +EK E +++P D K+ ++ K+EA E +
Sbjct: 325 QKEEEEKEVKEAPK-EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV------ 377
Query: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019
K E + KE+ K L +E K EKA ++++ S DK AKG
Sbjct: 378 KVHLEKETKEEGKPLQQEKEK---EKAGGEGGSEEEGS--------DKGAKG 418
Score = 110 bits (276), Expect = 5e-24
Identities = 132/487 (27%), Positives = 205/487 (42%), Gaps = 91/487 (18%)
Query: 267 VTSALREIRAQLEGHAVQSTLQS--EEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQ 324
V + E + + E ++ L + EE + EAA+ + + +EE+ +
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 136
Query: 325 LQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLRE 384
++A E++ + K+ E Q E E+ E + AE ++ E +++
Sbjct: 137 VKATAPEVKEEEGEKEEEEGQEEEEEE---------DEGAKSDQAEEGGSEKEGSSEKE- 186
Query: 385 YQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKI 444
EGE+ EG + + + K E+K
Sbjct: 187 ----------------------EGEQ------------EEGETEAEAEGEEAEAKEEKK- 211
Query: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
VEE++EE EE+ + + E K E+ K E +G KSP
Sbjct: 212 ------------VEEKSEEVATKEELVADAKVE-KPEKAKSPVPKSPVEEKGKSPVPKSP 258
Query: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
E+ SP KSPV+E+ KSP KSP +E+ KSP +KSP +E+AKS P
Sbjct: 259 VEEKGKSP--VPKSPVEEKGKSPV-PKSPVEEKGKSPV-------SKSPVEEKAKS-PVP 307
Query: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
KSP EEAKS AEV E+ + KE ++P E K +K + P ++ +A+SPVKE
Sbjct: 308 KSP-VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP--KDVPEKKKAESPVKE 364
Query: 625 EAKSPAEVKSPEKA-----KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
EA AEV + K+ + TKEE K ++ K EK + + + K AK K
Sbjct: 365 EA--VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG-AKGSRK 421
Query: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV--------KEEAKSPEKAKSPVKEEAK 731
V E + E+ + KE+ E+ K V +E K +K++ V K
Sbjct: 422 EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV-VVTK 480
Query: 732 TPEKAKS 738
T EK S
Sbjct: 481 TVEKITS 487
Score = 96.3 bits (238), Expect = 1e-19
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 20/295 (6%)
Query: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
K K + EE K ++ E+A T + E KEE + A+ EK + P
Sbjct: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITE--ELAVSMKEEKKEAAE---EKEEEPEA 125
Query: 791 EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850
EE + K KSP+K A ++E +KEE + +EEE+ + K + AEE +
Sbjct: 126 EEEEVAAK-KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ----AEEGGSEKE 180
Query: 851 PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA 910
+E+++ ++E + EA + E K+E VE+ E A KEE KV PEK
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV--ATKEELVADAKVEKPEK-- 236
Query: 911 PAKVEVKEDAKPKEKTEVAKKEPDDAKAKE--PSKPAEKKEAAPEKKDTKEEKAKKPEEK 968
AK V + ++ K P + K K P P E+K +P K EEK K P K
Sbjct: 237 -AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
Query: 969 PKTEAKAKEDDKTLSKEPSKPKAEKAE-KSSSTDQKDSK--PPEKATEDKAAKGK 1020
E KAK E +K KAE + + ++K+ K P E+ E K K K
Sbjct: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 350
Score = 94.0 bits (232), Expect = 7e-19
Identities = 82/265 (30%), Positives = 122/265 (46%), Gaps = 24/265 (9%)
Query: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE--IPKKEEVKSPVKEEE 828
K + +P K K + EE K E KS ++E A +E + KEE K +E+E
Sbjct: 62 KPKVEAPKLKVQHKFVEEIIEETKV-EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 829 KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888
+ E + +E K KA A P+ +E++ K+EE ++E + K + A E E
Sbjct: 121 EEPEAEEEEVAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE-VAKKE----------PDDAK 937
+ ++KEE E ++ E E + E KE+ K +EK+E VA KE P+ AK
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
Query: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK- 996
+ P P E+K +P K EEK K P K E K K S P P EK +
Sbjct: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK------SPVPKSPVEEKGKSP 292
Query: 997 -SSSTDQKDSKPPEKATEDKAAKGK 1020
S S ++ +K P + + AK K
Sbjct: 293 VSKSPVEEKAKSPVPKSPVEEAKSK 317
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 195 bits (496), Expect = 2e-49
Identities = 128/400 (32%), Positives = 206/400 (51%), Gaps = 19/400 (4%)
Query: 31 KGGAGGTRSAAGSSSGFHSWTRTSVSSVS-ASPSRFRGA-----GAASSTDSLDTLSNGP 84
K G R+ + S +R S SS S S FRG G AS + ++
Sbjct: 11 KVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQ 70
Query: 85 EGCMVAV--------ATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQ 136
V A EKEQ++ LN++FA +IDKVR LE N+ LE + + L+QQ+
Sbjct: 71 SLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQK 130
Query: 137 AGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAE 196
RS M ++E + +R + LG + +L E ++ + + + +DE +R E E
Sbjct: 131 TARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEME 190
Query: 197 AAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQ 256
+ + EA +V+L+ + + L +E +LR+ ++EE+ EL QI + +
Sbjct: 191 NEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDN 250
Query: 257 AETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQE 316
+ + D+ S + E++AQ E A +S ++E ++++ + L A + D +R +
Sbjct: 251 SRS-----LDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKT 305
Query: 317 EITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKW 376
EI+E R + E+E LK + SLE ++ E R + I + +L+A L+ K
Sbjct: 306 EISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQ 365
Query: 377 EMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFG 416
+MA QLREYQ+L+NVK+ALDIEIA YRKLLEGEE R+ G
Sbjct: 366 DMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESG 405
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 186 bits (471), Expect = 1e-46
Identities = 126/407 (30%), Positives = 216/407 (53%), Gaps = 17/407 (4%)
Query: 21 GGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDTL 80
G + + AR GG G + S G + S R +V S P GAG T + L
Sbjct: 21 GAQVRLSSARPGGLGSS-SLYGLGA---SRPRVAVRSAYGGPV---GAGIREVTINQSLL 73
Query: 81 SNGPEGCMVAVATSRSEK-EQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGR 139
+ ++ R E+ EQ++ LN++FA +IDKVR LE N+ LE + L++Q++ +
Sbjct: 74 APLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAK 133
Query: 140 SA-MGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAA 198
S+ + +++E ++ +RG + L G+L E + + + + + +DE R AE
Sbjct: 134 SSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENE 193
Query: 199 ARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAE 258
L + A ++V+L+ K AL +E +LR ++ E+ EL QI + + +
Sbjct: 194 FVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSR 253
Query: 259 TRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEI 318
+ D+ + E++AQ E A S ++E W++ + + L A + D +R+ + EI
Sbjct: 254 S-----LDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEI 308
Query: 319 TEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEM 378
+E R +Q E++ +K+ + LE +E E+R + + + ++L+A L+ K +M
Sbjct: 309 SEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDM 368
Query: 379 AAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
A QLREYQ+L++VK+ALDIEIA YRKLLEGEE R+ G G + S+
Sbjct: 369 ARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISV 415
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 182 bits (462), Expect = 1e-45
Identities = 128/395 (32%), Positives = 194/395 (49%), Gaps = 21/395 (5%)
Query: 20 GGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDT 79
GGGS + GG G GS+ G S SS S+ S G G SS +D
Sbjct: 21 GGGSSRTSCRLSGGLGAGSCRLGSAGGLGS--TLGGSSYSSCYSFGSGGGYGSSFGGVDG 78
Query: 80 LSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQA-G 138
L G EK +Q LNDR A Y+DKVR LE N LE + Q+QA G
Sbjct: 79 LLAG------------GEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPG 126
Query: 139 RSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAA 198
+ Y R + E++ +L + L+ ++ R + + E R EA
Sbjct: 127 PARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEAD 186
Query: 199 ARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAE 258
L R E AR DL+ + + L+EE YL+++H+EE+ L GQ+ G ++ E
Sbjct: 187 INGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGG------EINVE 240
Query: 259 TRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEI 318
A D++ L E+R Q E A ++ +E+WF + + L+ N++ ++S + EI
Sbjct: 241 MDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEI 300
Query: 319 TEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEM 378
+E RR +QA EL++ S K SLE +E E+R+ ++ Q I ++ +L + EM
Sbjct: 301 SELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEM 360
Query: 379 AAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRI 413
Q +EY+ LL+VK L+ EIA YR+LLEGE+ +
Sbjct: 361 EQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL 395
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 178 bits (452), Expect = 2e-44
Identities = 106/331 (32%), Positives = 184/331 (55%), Gaps = 10/331 (3%)
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQ--QAGRSAMGELYEREVREMR 154
E+EQ++ LN++FA +IDKVR LE N+ LE + A L++Q + R + L++ E+R
Sbjct: 149 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELR 208
Query: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
+ + RG+L E ++ + + + R +DE +R AE AL + A +V
Sbjct: 209 RQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKV 268
Query: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
+L+ K ++L EE ++ E+ +L Q+ G + + L D+ S + E+
Sbjct: 269 ELEAKVKSLPEEINFIHSVFDAELSQLQTQV---GDTSVVLSMDNNRNL--DLDSIIAEV 323
Query: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
+AQ E A +S ++E W++ + + L A + D +R+ ++EI+E R +Q E+++
Sbjct: 324 KAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDS 383
Query: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
+K SL+ ++ E R + + + + L+ L+ K +MA LREYQ+L+N+K+A
Sbjct: 384 VKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLA 443
Query: 395 LDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
LD+EIA YRKLLEGEECR+ G P+ S+
Sbjct: 444 LDVEIATYRKLLEGEECRLSGEGVSPVNISV 474
>gi|4557699 keratin 12 [Homo sapiens]
Length = 494
Score = 177 bits (450), Expect = 3e-44
Identities = 142/472 (30%), Positives = 220/472 (46%), Gaps = 39/472 (8%)
Query: 21 GGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSS-VSASPSRFRGAGA--------- 70
GGS A GG S GSSSGF + +S++ + A R G G+
Sbjct: 43 GGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFG 102
Query: 71 -ASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEG-- 127
+ SL LS G + S SEKE +Q LNDR A Y+DKVR LE N LE
Sbjct: 103 GSPGGGSLGILSGNDGGLL-----SGSEKETMQNLNDRLASYLDKVRALEEANTELENKI 157
Query: 128 ----EAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQ 183
E A +S + Y + ++R ++ QL L+ ++ R
Sbjct: 158 REWYETRGTGTADASQSDYSKYYPL-IEDLRNKIISASIGNAQLLLQIDNARLAAEDFRM 216
Query: 184 RLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLG 243
+ ++E R+ EA L R E R DL+ + ++L EE Y++++H++E+
Sbjct: 217 KYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSF-- 274
Query: 244 QIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEA 303
++ G G +M A A D+T L ++RAQ E A Q+ +E WF + L +
Sbjct: 275 RVGGPGEVSVEMDA----APGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKE 330
Query: 304 AKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEA 363
NT+ ++S++ E+T+ RR Q EL++ + K SLE +E E + A ++ Q+
Sbjct: 331 ISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQL 390
Query: 364 IQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLP 423
I L+A+L + + Q ++Q LLNVK L++EI YR+LL+GE G L
Sbjct: 391 ISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDG-------LE 443
Query: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475
E L S S + +S + K K+ K +V+E V+ +V E EE
Sbjct: 444 ESLFVTDSKS---QAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEE 492
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 174 bits (440), Expect = 5e-43
Identities = 134/455 (29%), Positives = 208/455 (45%), Gaps = 22/455 (4%)
Query: 12 GAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAA 71
G+ AP GG L + +R G G GF S + + S GAG
Sbjct: 38 GSCRAPSTYGGGLSVSSSRFSSGGAYGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLG 97
Query: 72 SSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAA 131
G +G +V SEK +Q LNDR A Y+DKVR LE N LE +
Sbjct: 98 GGFGGGFA---GGDGLLVG-----SEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRD 149
Query: 132 LRQQQAGRSAMG-ELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEAR 190
Q+Q Y + + ++R +L + L+ ++ R + + E
Sbjct: 150 WYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELN 209
Query: 191 QREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGA 250
R EA L R E AR DL+ + ++L+EE YL+++H+EE+ L GQ+ G
Sbjct: 210 LRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGD-- 267
Query: 251 AQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDA 310
+ E A D++ L E+R Q E A ++ +EEWF + + L+ N++
Sbjct: 268 ----VNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSEL 323
Query: 311 MRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAE 370
++S + EI+E RR +Q EL++ S K SLE E + R+ +A QE I ++ +
Sbjct: 324 VQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQ 383
Query: 371 LRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIP 430
L + EM Q +EY+ LL+VK L+ EIA YR+LLEGE+ + S + +
Sbjct: 384 LAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFS-SGSQSSRDVT 442
Query: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQ 465
S S I+ KV++ + + V EQ T+
Sbjct: 443 SSSRQIRT------KVMDVHDGKVVSTHEQVLRTK 471
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 172 bits (437), Expect = 1e-42
Identities = 208/659 (31%), Positives = 272/659 (41%), Gaps = 124/659 (18%)
Query: 442 EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE--EEGGEEEEAEGGEE 499
+++ ++E+ E+ + EE+ Q EE E EE + KE E E EE + EE E E
Sbjct: 9718 KEVTIMEEKERAYTL-EEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREY 9776
Query: 500 ETKSPPAEEAASPEKEA------KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP 553
E E PEK + PV + K+P AK +K + V P+K K P
Sbjct: 9777 ERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPP-AKVLKKAVPEEKVPVPIPKKLKPP 9835
Query: 554 ---AKEEAKSPPEAK------SPEKEEAKSPA--------EVKSPEKAKSPAKEEA---- 592
EE K E K EKE+ PA V + EK P KE A
Sbjct: 9836 PPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVR 9895
Query: 593 --KSPAEAKSPEKAKSP----------VKEEAKSPAEAKSPVKEEAKSPA-EVKSPEKAK 639
+ P E + E A V+EE + E + + EE P VK PE +
Sbjct: 9896 VPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPR 9955
Query: 640 SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV-KAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
P EE K K E AK PE K P K P+K K P AK PE K PV
Sbjct: 9956 KPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPP---PAKVPEVPKKPV 10012
Query: 699 KEE--------------AKSPEKAKSPVKEE---AKSPEKAKSPVKEEAKTPEKAKSPVK 741
EE AK PE K PV E+ +P+K ++P AK PE K +
Sbjct: 10013 PEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAP---PAKVPEVPKKLIP 10069
Query: 742 EEAKS---PEKAKSPEKA---KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKS 795
EE K P+K ++P K V P A P +EE + PE+ P +EEV
Sbjct: 10070 EEKKPTPVPKKVEAPPPKVPKKREPVPVPVA-LPQEEEVLFEEEIVPEEEVLPEEEEVLP 10128
Query: 796 PEKAKSPLKEDAKAPEKEIPKKEEVKSP-----------VKEEEKPQEVKVKEPP----- 839
E+ P +E+ E+EIP +EE P V EEE EVK K P
Sbjct: 10129 EEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVP 10188
Query: 840 --KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV------E 891
KK EK PK EE +K E PK KVEEK+ + PKE +V E
Sbjct: 10189 EIKKKVTEKKVVIPKKEEAPPAKVPEVPK------KVEEKR---IILPKEEEVLPVEVTE 10239
Query: 892 AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951
+EE ++++P E P +E E+ P EV KK +A P KK A
Sbjct: 10240 EPEEEPISEEEIP----EEPPSIEEVEEVAPPRVPEVIKKAVPEAPT-----PVPKKVEA 10290
Query: 952 PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
P K +K K PEEK + KE +K P PK + EK +K++ PP K
Sbjct: 10291 PPAKVSK----KIPEEKVPVPVQKKEAPP--AKVPEVPK-KVPEKKVLVPKKEAVPPAK 10342
Score = 169 bits (427), Expect = 2e-41
Identities = 197/703 (28%), Positives = 292/703 (41%), Gaps = 78/703 (11%)
Query: 317 EITEYRRQL-QARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTK 375
++TE+R+++ + +EA K + ++ + +E++ +A + Q + E +
Sbjct: 9691 KVTEFRKRVVKEEKVSIEAPKREPQPI-KEVTIMEEKERAYTLEEEAVSVQREEEYEEYE 9749
Query: 376 WEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEEC------RIGFGPIPFSLPEGLPKI 429
+ EY+ + E Y + E EE I P+P PK
Sbjct: 9750 EYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKA 9809
Query: 430 PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEE-----VTEEEEKEAKEEEGK 484
P K EEK+ V + + + E +V EE +T+ E+++ E K
Sbjct: 9810 PPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAK 9869
Query: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
+ AE E+ P KE PV+ P K E EE EV
Sbjct: 9870 VPMKPKRVVAE-----------EKVPVPRKEVAPPVRV----PEVPKELEPEEVAFEEEV 9914
Query: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604
+ + +EE E + +EE VK PE + P EE K K E
Sbjct: 9915 VTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAP 9974
Query: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
+ V E K P E + + + P K PE K P EE K E AK PE
Sbjct: 9975 PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPE 10034
Query: 665 KAKSPV---KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS---PEKAKSPVKEEAKS 718
K PV K +P+K ++P AK PE K + EE K P+K ++P + K
Sbjct: 10035 VPKKPVPEKKVPVPAPKKVEAP---PAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKK 10091
Query: 719 PEKAKSPVK---------EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP 769
E PV EE PE+ P +EE E+ PE+ + L E + P
Sbjct: 10092 REPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVL---PEEEEIP 10148
Query: 770 AKEEARSPADKF-PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK---EEVKSPVK 825
+EE P +++ PE+ + +EEV K K P+ AP EI KK ++V P K
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPV----PAPVPEIKKKVTEKKVVIPKK 10204
Query: 826 EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
EE P KV E PKK EE++ PK EE + E P++E + ++ P++E+
Sbjct: 10205 EEAPP--AKVPEVPKKVEEKRI-ILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEV 10261
Query: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
+E V + KK VP EAP V K +A P +V+KK P++ K P P
Sbjct: 10262 EE--VAPPRVPEVIKKAVP----EAPTPVPKKVEAPP---AKVSKKIPEE---KVP-VPV 10308
Query: 946 EKKEAAPEKKDTKEEKAKKPEEK---PKTEAKAKEDDKTLSKE 985
+KKEA P K E K PE+K PK EA +T+ +E
Sbjct: 10309 QKKEAPPAK--VPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEE 10349
Score = 168 bits (426), Expect = 2e-41
Identities = 215/725 (29%), Positives = 291/725 (40%), Gaps = 152/725 (20%)
Query: 419 PFSLPEGLPKIPSVSTHIKVKS-----------EEKIKVVEKSEKETVIVEEQTE----E 463
P +PE K+P + K EEK+ V + E V+V+E+ E E
Sbjct: 10315 PAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQE---VVVKERLELEVVE 10371
Query: 464 TQVTEEVTEEEEKEAKE--EEGK----------EEEGGEEE-------------EAEGGE 498
+V E EEE E +E EEG+ E+ EEE EAE E
Sbjct: 10372 AEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVE 10431
Query: 499 --EETKSPPA----EEAASPEKEAKSPVKEEAKSPAEAKSPE-------KEEAKSPAEVK 545
E+ K+PP E P K K P K + AK PE +E+ + P E +
Sbjct: 10432 VFEKPKAPPKGPEISEKIIPPK--KPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPR 10489
Query: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE------VKSPEKAKSPAKEEAKSPAEAK 599
P P K PP+ PEK+ PA+ K PE K E+ K
Sbjct: 10490 VP-----PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPK 10544
Query: 600 SPEKAKSPVKEEAKS-----------PAEAKSPVKEEAKSPAEV-----------KSPE- 636
PE + V E K+ P + +SP E ++P EV K PE
Sbjct: 10545 KPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEV 10604
Query: 637 -KAKSPTKEEAKSPEK------AKSPEKEEAKSPEKAKSPV---KAEAKSPEKAKSPVKA 686
K P + PEK K PE K PE K V K P K +SP
Sbjct: 10605 TPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPE 10664
Query: 687 EAKSPEKA--KSPVKEEAKSPEKA---------KSPVKEEAKSPEKAKSPVKEEAKTPEK 735
+ PE+ + P E + PE A K PV E+ AK P K PE
Sbjct: 10665 VFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEV 10724
Query: 736 AKSPVKEE------AKSPE--KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
K V E+ K PE AK PE K + PE K ++ P K PE K
Sbjct: 10725 PKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEV---VPEKKVAVPKKPEVPPAKVPEVPKK 10781
Query: 788 PVKEE---VKSPEKAKSPLKE-----DAKAPEKEIPKKEEVKSPVKEEEKPQ---EVKVK 836
PV EE V PE+A+SP E + APE+EI +EE PV EEE+P+ +
Sbjct: 10782 PVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPE 10841
Query: 837 EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK--K 894
EP K E+K P K E KE P+K KPK++ + P P + V+ K +
Sbjct: 10842 EPKKIIPEKKVPVIKKPE--APPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQ 10899
Query: 895 EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEK 954
+A KKKVP + + P KVE+ P + +V K P+ KP K+E +
Sbjct: 10900 LKAIPKKKVP-EKPQVPEKVELTPLKVPGGEKKVRKLLPE-------RKPEPKEEVVLKS 10951
Query: 955 KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE--KAT 1012
K + ++P+ +PK K K K EP PK + + + +++ K PE K
Sbjct: 10952 VLRKRPEEEEPKVEPKKLEKVK---KPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVP 11008
Query: 1013 EDKAA 1017
E K A
Sbjct: 11009 EIKPA 11013
Score = 166 bits (420), Expect = 1e-40
Identities = 213/755 (28%), Positives = 313/755 (41%), Gaps = 114/755 (15%)
Query: 341 SLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREY---QDLLNVKMALDI 397
S E + S E+ I+ Y+E ++ + E T++E+ + EY + L + ++
Sbjct: 9490 SAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEA 9549
Query: 398 EIAAYRKLLEGEECRIGFGP-IPFSLPEGLP-KIPSVSTHI------------------- 436
E A ++ E +E +I P IP + E P K+P I
Sbjct: 9550 EPA---EVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPP 9606
Query: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTE---EVTEEEE----KEAKEEEGKEEEGG 489
KV E K V EK VI E+ +VTE ++T+EE+ KE K
Sbjct: 9607 KVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPE 9666
Query: 490 EEEEAEGGEEETKSPPAEEAASPEKEA---KSPVKEE---AKSPAEAKSPEKE----EAK 539
E + A E+ K P E P K K VKEE ++P P KE E K
Sbjct: 9667 EPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEK 9726
Query: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
A E +EE + E E EE + E E+ + E + E
Sbjct: 9727 ERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYI 9786
Query: 600 SPEKAKSPVKEEAKSPAEAK---SPVKEEAKSPAE----VKSPEKAKSPTKEEAKSPEKA 652
+ + PVK + P K P K K+ E V P+K K P + + P+K
Sbjct: 9787 TEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKV 9846
Query: 653 ---------KSPEKEEAKSPEKAKSPVK-----AEAKSPEKAKSPVKAEAKSPEKAKSPV 698
EKE+ P AK P+K AE K P K V + PE K
Sbjct: 9847 FEEKIRISITKREKEQVTEP-AAKVPMKPKRVVAEEKVPVPRKE-VAPPVRVPEVPKELE 9904
Query: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE------------AKTPEKAKSPVKEEAKS 746
EE E+ + V+E E+ +EE K PE + PV EE K
Sbjct: 9905 PEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKP 9964
Query: 747 ---PEKAKSPEKAKTLDV-KSPEAKTPA--KEEARSPADKFPEKAKSPVKEE---VKSPE 797
P+K ++P AK +V K PE K P ++ + P K PE K PV EE V P+
Sbjct: 9965 VPVPKKKEAP-PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPK 10023
Query: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
K ++P + + P+K +P+K K PV P KV+ PP K P PK +
Sbjct: 10024 KVEAPPAKVPEVPKKPVPEK---KVPV-----PAPKKVEAPP-----AKVPEVPKKLIPE 10070
Query: 858 DSKKEEAPKK-EAPKPKVEEKKEPA---VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
+ K PKK EAP PKV +K+EP V P+E +V ++E +++ +P E+ P +
Sbjct: 10071 EKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEE 10130
Query: 914 VEV---KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK 970
EV +E+ P+E E E ++ +E P E++E PE++ E K K P P
Sbjct: 10131 EEVLPEEEEVLPEE--EEIPPEEEEVPPEEEYVP-EEEEFVPEEEVLPEVKPKVPVPAPV 10187
Query: 971 TEAKAKEDDK--TLSKEPSKPKAEKAEKSSSTDQK 1003
E K K +K + K+ P A+ E ++K
Sbjct: 10188 PEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEK 10222
Score = 166 bits (420), Expect = 1e-40
Identities = 187/671 (27%), Positives = 271/671 (40%), Gaps = 77/671 (11%)
Query: 404 KLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEE 463
++ E EE + F P+ PK P +S I + KVV + E V E ++
Sbjct: 10423 EVFEAEEVEV------FEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAK-VPEVPKK 10475
Query: 464 TQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE 523
V E+V EE + E +E E ++ PPA++ +P + KE
Sbjct: 10476 IVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPE---KKVPVPPAKKPEAPPPKVPEAPKEV 10532
Query: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS-PPEAKSPEKEEAKSPAEVKSPE 582
P K+ P +V KA P K+ ++ PP+ +SP E ++P EV PE
Sbjct: 10533 VPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVV-PE 10591
Query: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642
K A + K PE K V E+ K P P K+ P +V K P
Sbjct: 10592 KKVPAAPPKKPEVTPVKVPEAPKEVVPEK-KVPVP---PPKKPEVPPTKVPEVPKVAVPE 10647
Query: 643 KEEAKS-PEKAKSPEKEEAKSPEKA--KSPVKAEAKSPEKAKSP---VKAEAKSPEK--- 693
K+ ++ P K +SP E + PE+ + P + PE A P V + PEK
Sbjct: 10648 KKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAP 10707
Query: 694 ---AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
AK P K PE K V E+ K P AK PE K V E+ K
Sbjct: 10708 AVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEK-----KV 10762
Query: 751 KSPEKAKTLDVKSPEA-KTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA 809
P+K + K PE K P EE PA PE+A+SP E + PE+ +P +E A
Sbjct: 10763 AVPKKPEVPPAKVPEVPKKPVLEE--KPAVPVPERAESPPPEVYEEPEEI-APEEEIAPE 10819
Query: 810 PEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK--- 866
EK +P EE + V P+E K P KK K P P +E + K E PK
Sbjct: 10820 EEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKP 10879
Query: 867 ----------KEAPKPKVEEKKE-PAVEKPKESKVEAKKE---------EAEDKKKVPTP 906
KE K K+ + K P + P++ +V K E E + +K +P
Sbjct: 10880 RPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPER 10939
Query: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDD-AKAKEPS-------KPAEKKEA-------- 950
+ E +V +K + + + E K EP K K+P+ KP E+ E
Sbjct: 10940 KPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER 10999
Query: 951 -APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009
PE E K P P+ + K + + KT+ P +P+ + K
Sbjct: 11000 KIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEA 11059
Query: 1010 KATEDKAAKGK 1020
KA +++AAK K
Sbjct: 11060 KAPKEEAAKPK 11070
Score = 150 bits (378), Expect = 8e-36
Identities = 162/580 (27%), Positives = 233/580 (40%), Gaps = 54/580 (9%)
Query: 423 PEGLPKIPS-------VSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE 475
P +P++P V I K E V ++ KE V ++ EVT +
Sbjct: 10550 PTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKV 10609
Query: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK 535
EA +E E++ + TK P + A PEK+ + + +SP E
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEP 10669
Query: 536 EEA---KSPAEV-KSPEKAKSPAKEEAKSPPEAKSPEKEE----AKSPA--EVKSPEKAK 585
EE + PAEV + PE A P + PP+ PEK+ AK P VK PE K
Sbjct: 10670 EEVALEEPPAEVVEEPEPAAPP---QVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPK 10726
Query: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEE 645
E+ K PE + V E K K + K PE K P EE
Sbjct: 10727 EVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEE 10786
Query: 646 AKS---PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA 702
+ PE+A+SP E + PE+ E +PE+ K AE + PE V EE
Sbjct: 10787 KPAVPVPERAESPPPEVYEEPEEI---APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEP 10843
Query: 703 KS--PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
K PEK +K+ P K P K EK K + P K K K
Sbjct: 10844 KKIIPEKKVPVIKKPEAPPPKEPEP----EKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQ 10899
Query: 761 VKS-PEAKTPAKEEARSPADKFPEKAK-SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE 818
+K+ P+ K P K + PEK + +P+K V EK L PE++ KE
Sbjct: 10900 LKAIPKKKVPEKPQV-------PEKVELTPLK--VPGGEKKVRKL-----LPERKPEPKE 10945
Query: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP-----KKEAPKPK 873
EV ++P+E + K PKK E+ K PA P+ K ++ E P +++ P+P
Sbjct: 10946 EVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPT 11005
Query: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
+ +PA+ P + E + K P + P V K+ A KE
Sbjct: 11006 KVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKE- 11064
Query: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEA 973
+ AK K P K KK +P + + ++ + EKP EA
Sbjct: 11065 EAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEA 11104
Score = 146 bits (369), Expect = 8e-35
Identities = 211/735 (28%), Positives = 300/735 (40%), Gaps = 142/735 (19%)
Query: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVE-EQTEETQVTEE----VT 471
P+P P PK+P V K EEKI V +KE + + ++ VTEE VT
Sbjct: 9332 PVPKKEPAAPPKVPEVPK--KPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVT 9389
Query: 472 EEEEKE--AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAAS----PEKEAKSPVKEEAK 525
+ EE A E K++ E + EEE PP A PE++ PV K
Sbjct: 9390 QREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKK 9449
Query: 526 SPAEAKSPEK----EEAKSPAEVKS----PEKAKSPAKEEAKSPPEAKSPEKEEAKSPA- 576
+P K EE + AE K P++ + + E + E E+EE S +
Sbjct: 9450 APPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEV-TRHEVSAEEEWSYSEEEEGVSISV 9508
Query: 577 ----EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA----KSPVKEEAKS 628
E + E+A+ E + P E EK K PAE + + + K
Sbjct: 9509 YREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKI 9568
Query: 629 PAEVKSPEKAKSPTKEEAKSPEK---AKSPEKEEA---KSPEKAKSPVKAEAKSPE--KA 680
PA+++ P AK P + PEK A P+KE+ K PE+ K PV + P+ K
Sbjct: 9569 PAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKM 9628
Query: 681 KSPVKA--------------------------EAKSPEKAKSPVKEE------------- 701
+ P+ A +A+ PE+ K V EE
Sbjct: 9629 EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEP 9688
Query: 702 -AKSPEKAKSPVKEE---AKSPEKAKSPVKEEAKTPEKAKS-PVKEEAKSPEKAKSPEKA 756
AK E K VKEE ++P++ P+KE EK ++ ++EEA S ++ + E+
Sbjct: 9689 PAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEY 9748
Query: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE-VKSPEK-------AKSPLKEDAK 808
+ D K E P +E + + E + EE + PEK + P+ K
Sbjct: 9749 EEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPK 9808
Query: 809 APEKEIPKK----EEVKSPVKEEEKPQEVKVKEPPKKAEEE------------------- 845
AP ++ KK E+V P+ ++ KP KV E PKK EE
Sbjct: 9809 APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAA 9868
Query: 846 KAPATPK---TEEKKD-SKKEEAPKKEAPK-PKVEEKKEPAVEKP-----KESKVEAKKE 895
K P PK EEK +KE AP P+ PK E +E A E+ +E VE ++E
Sbjct: 9869 KVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEE 9928
Query: 896 EAEDKKKVPTPEKEA---PAKV-EVKEDAKPKEKTEV---AKKEPDDAKAKE-PSKPAEK 947
++++ T E+ P KV EV P+EK V KKE AK E P KP EK
Sbjct: 9929 YIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEK 9988
Query: 948 KEAAPEKKDTKEEKAKKPE--EKPKTEAKA-----KEDDKTLSKEPSKPKAEKAEKS--S 998
KK+ K AK PE +KP E K K+ + +K P PK EK
Sbjct: 9989 VPVLIPKKE-KPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPV 10047
Query: 999 STDQKDSKPPEKATE 1013
+K PP K E
Sbjct: 10048 PAPKKVEAPPAKVPE 10062
Score = 146 bits (368), Expect = 1e-34
Identities = 205/725 (28%), Positives = 281/725 (38%), Gaps = 147/725 (20%)
Query: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
E + K P +T I K+ E I V K+E+ ++ + +E Q +E E+++ +E+
Sbjct: 9008 EIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKR 9067
Query: 484 ----KEEEGGEEEEAEGGEEETKSP----PAEEAASPEKEAKSPVKEEAKSPAEAKSP-- 533
EE +E E E E + P P E+ + EAK V EE + E
Sbjct: 9068 VFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYY 9127
Query: 534 -----------EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP- 581
E EEA EV +K E K P AK PEK+ P +K P
Sbjct: 9128 EREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVP--AKVPEKKAPPPPKVIKKPV 9185
Query: 582 ----EKAKSPAKEE----AKSPAEAKS--PEK-AKSPVKEEA---KSPA---------EA 618
EK +EE K P +K P+K +++PV+EE K PA E
Sbjct: 9186 IEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEE 9245
Query: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEA--KSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676
K + V PE K EE + K P + + PEK A
Sbjct: 9246 KMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPI 9305
Query: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE------- 729
P+K + P K PE K PV EE K K K PE K PV EE
Sbjct: 9306 PKKVEPPAP---KVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVA 9362
Query: 730 -------AKTPEKAKSPVKEE----AKSPEKAKSPEKAKTLDVKSPEAK--TPAKEEARS 776
AK PE K V EE E++ P + K PE + P KEE
Sbjct: 9363 KKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVP 9422
Query: 777 PADKFPEKAKSPVKEE-----VKSPEKAKSPLKEDAK----------APEK---EIPKKE 818
P K P K PV EE V +KA P E +K A EK +P++
Sbjct: 9423 PPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRV 9482
Query: 819 EVK---------------------SPVKEEEKPQ-------EVKVKEPP----------- 839
EV S +EEE+ + E +V E P
Sbjct: 9483 EVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHI 9542
Query: 840 --KKAEEEKAPATPKTEE------KKDSKKEEAPK---KEAPKPKVEEKKEPAVEKPKES 888
K+ E E A T + E+ K +K EE P EAPK V EKK PA PK+
Sbjct: 9543 ISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPA-PVPKKE 9601
Query: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948
KV K E KK P PEK+ P KV E+ P + TE + + ++ KK
Sbjct: 9602 KVPPPKVPEEPKK--PVPEKKVPPKVIKMEEPLPAKVTE---RHMQITQEEKVLVAVTKK 9656
Query: 949 EAAPEKKDTKEEKAKKPEEKP-KTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007
EA P+ + +E K PEEK K + K +E+ E K ++ + S +++ +P
Sbjct: 9657 EAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQP 9716
Query: 1008 PEKAT 1012
++ T
Sbjct: 9717 IKEVT 9721
Score = 145 bits (365), Expect = 2e-34
Identities = 161/615 (26%), Positives = 251/615 (40%), Gaps = 44/615 (7%)
Query: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEE-----VTEEEEKEAKEEE 482
K+P+V T V SEEK+ +E+E + + ++ VTEE +++ E K E
Sbjct: 9231 KVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPE 9290
Query: 483 GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
E+ EE ++ + P + P+K PV EE K P+KE A P
Sbjct: 9291 LPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKK----PVPEEKKP---VPVPKKEPAAPP- 9342
Query: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS--PEKAKSPAKEEAKSPAEAKS 600
K PE K P EE P AK E AK P K E+ + + +SP A
Sbjct: 9343 --KVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAV- 9399
Query: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP---EKAKSPTKEEAKSPEKAKSPEK 657
PE K V EE K + V K PA K P EK P K+P K
Sbjct: 9400 PEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSK 9459
Query: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
+ ++ + K P++ + + E + E+ +EE S + +EE +
Sbjct: 9460 KTVVEEKRFVAEEKLSFAVPQRVEV-TRHEVSAEEEWSYSEEEEGVSISVYREEEREEEE 9518
Query: 718 SPEKAKSPVKEEAKT-PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776
E + V EE + + K + + E A+ E+ + V P K PAK E
Sbjct: 9519 EAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKP--KIPAKIEEPP 9576
Query: 777 PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV-KV 835
PA K PE K V E+ K +P+ + K P ++P EE K PV E++ P +V K+
Sbjct: 9577 PA-KVPEAPKKIVPEK-----KVPAPVPKKEKVPPPKVP--EEPKKPVPEKKVPPKVIKM 9628
Query: 836 KEP-PKKA---------EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
+EP P K EE+ A K E ++ E PK+ P+ KV + K E+P
Sbjct: 9629 EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEP 9688
Query: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
E +K +++K K P ++ + KE+ ++E + +E +
Sbjct: 9689 PAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEY 9748
Query: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
E+ + ++ E+ + EE + E + E+ + EP KP K K
Sbjct: 9749 EEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPK 9808
Query: 1006 KPPEKATEDKAAKGK 1020
PP K + + K
Sbjct: 9809 APPAKVLKKAVPEEK 9823
Score = 135 bits (341), Expect = 1e-31
Identities = 161/533 (30%), Positives = 209/533 (39%), Gaps = 52/533 (9%)
Query: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTE--EVTEEEEKEAK 479
+P PK P V T +KV K V EK + + T+V E +V E+K +
Sbjct: 10594 VPAAPPKKPEV-TPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPE 10652
Query: 480 EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK 539
K E E E E + PPAE PE A V K P K AK
Sbjct: 10653 AIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAK 10712
Query: 540 SPA--EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS--PEKAKSPAKEEAKSP 595
P VK PE K E+ K PE AK P K PEK + K+ P
Sbjct: 10713 KPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPP 10772
Query: 596 AEAKSPEKAKSPVKEEAKS---PAEAKSPVKEEAKSPAEVK-----SPEKAKSPTKEEAK 647
A K PE K PV EE + P A+SP E + P E+ +PE+ K E +
Sbjct: 10773 A--KVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEE 10830
Query: 648 SPEKAKSPEKEEAKS--PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP 705
PE EE K PEK +K P K P K K K + P A
Sbjct: 10831 EPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPK 10890
Query: 706 EKAKSPVKE-----EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
E K + + + K PEK + P K E TP K K+ K + K PE + +
Sbjct: 10891 EDVKEKIFQLKAIPKKKVPEKPQVPEKVEL-TPLKVPGGEKKVRKLLPERK-PEPKEEVV 10948
Query: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP---EKAKSPL--KEDAKAPEK-EI 814
+KS K P +EE + K EK K P E P E+ + P K + K PE ++
Sbjct: 10949 LKSVLRKRPEEEEPKVEPKKL-EKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKV 11007
Query: 815 PK-KEEVKSPVKEEEKPQEVKVK---------EPPKKAEEEKAPATPKTEEKKDSKKEEA 864
P+ K + P E + E +VK EP A P K E K A
Sbjct: 11008 PEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAK------A 11061
Query: 865 PKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917
PK+EA KPK K V K S +EA++ + P EAP ++K
Sbjct: 11062 PKEEAAKPKGPIK---GVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLK 11111
Score = 119 bits (298), Expect = 1e-26
Identities = 147/572 (25%), Positives = 231/572 (40%), Gaps = 72/572 (12%)
Query: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559
E K PP + +K K K+ P E +P +E K P + AK+P +
Sbjct: 8973 EEKKPPPKRIEVTKKAVKKDAKKVVAKPKE-MTPREEIVKKPPPPTTLIPAKAPEIIDVS 9031
Query: 560 SPPE---------AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
S E K +KE+ + ++ K K E + P + E P ++
Sbjct: 9032 SKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQ 9091
Query: 611 E-AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
+ P E +K EAK EV + +E E+ +EE + + +
Sbjct: 9092 PYYEEPDEDYEEIKVEAKK--EVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREV 9149
Query: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP-----EKAKSPVKEE----AKSPE 720
++ + + E++ K AK PEK P + K P EK ++EE K PE
Sbjct: 9150 IQVQKEVYEESHER-KVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPE 9208
Query: 721 KAK---------SPVKEEAKTPEKAKSPVKEEAKSPEK---AKSPEKAKTLDVKSPEAKT 768
+K +PV+EE + K+ S EK A E+ ++ V + +
Sbjct: 9209 VSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEI 9268
Query: 769 PAKEEAR-------SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK 821
+E+ P K PE + P EEV A P+ + + P ++P E K
Sbjct: 9269 VTEEKIHVAISKRVEPPPKVPELPEKPAPEEV-----APVPIPKKVEPPAPKVP--EVPK 9321
Query: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK---KDSKKEEAPKKEAP---KPKVE 875
PV EE+KP V KEP + + P P EEK +KK+EAP + P K V
Sbjct: 9322 KPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVT 9381
Query: 876 EKKEPAVEKPKESKVEA-----KKEEAEDKKKVPTPEKEAPAKVEVKE-DAKPKEKTEVA 929
E+K V + +ES A KK+ E++K VP E+E P +V KP + +VA
Sbjct: 9382 EEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVA 9441
Query: 930 KKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEK----AKKPEEKPKTEAKAKEDDKTLSKE 985
P KA P KK EK+ EEK + E + E A+E+ +E
Sbjct: 9442 VPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEE 9501
Query: 986 PS-------KPKAEKAEKSSSTDQKDSKPPEK 1010
+ + E+ E++ T+ + + PE+
Sbjct: 9502 EGVSISVYREEEREEEEEAEVTEYEVMEEPEE 9533
Score = 110 bits (274), Expect = 9e-24
Identities = 137/523 (26%), Positives = 211/523 (40%), Gaps = 61/523 (11%)
Query: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA-EVKSPEKAK 585
P A PE+ P V P P EE K PP+ K+ K A +V + K
Sbjct: 8948 PIRAVPPEE----IPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEM 9003
Query: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE--------AKSPVKEEAKSPAEVKSP-- 635
+P +E K P + AK+P + S AE K V++E ++ E K
Sbjct: 9004 TPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVH 9063
Query: 636 -------EKAKSPTKEEAKSP--EKAKSPEKEEAKSPEKAKSPVKAEAKSP--------- 677
E + P E P E + P EE P++ +K EAK
Sbjct: 9064 KEKRVFIESFEEPYDELEVEPYTEPFEQPYYEE---PDEDYEEIKVEAKKEVHEEWEEDF 9120
Query: 678 EKAKSPVKAEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735
E+ + + E E+ +E + + K +E + AK P K+ P+
Sbjct: 9121 EEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKV 9180
Query: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP---VKEE 792
K PV E+ + + EK + V K ++ +R+P + + K P K+
Sbjct: 9181 IKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKM 9240
Query: 793 VKSPEKA--KSPLKEDAKAP----EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
V S EK S +E+ +KEI +E++ + + +P + P K A EE
Sbjct: 9241 VISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEV 9300
Query: 847 APA-TPKTEEKKDSKKEEAPKKEAP---KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK 902
AP PK E K E PKK P KP KKEPA PK +V KK E+K
Sbjct: 9301 APVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAA-PPKVPEV-PKKPVPEEKIP 9358
Query: 903 VPTPEKE--APAKV-EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
VP +K+ PAKV EV++ +EK + + + P P +K + KE
Sbjct: 9359 VPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKE 9418
Query: 960 EKAKKPEEKPKTEAKAKEDDKT-----LSKEPSKPKAEKAEKS 997
E+ P + P K ++K ++K+ P+AE ++K+
Sbjct: 9419 EEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKT 9461
Score = 97.8 bits (242), Expect = 5e-20
Identities = 125/440 (28%), Positives = 177/440 (40%), Gaps = 47/440 (10%)
Query: 419 PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEE----VTEEE 474
P + P +P++P +V E+K+ V +K E V E ++ + E+ V E
Sbjct: 10742 PEAPPAKVPEVPK-----EVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERA 10796
Query: 475 EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP- 533
E E + EE EEE EE K P E PE + +E K E K P
Sbjct: 10797 ESPPPEVYEEPEEIAPEEEI--APEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPV 10854
Query: 534 -EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA-------EVKSPEKAK 585
+K EA P E + PEK K + + PP +P KE+ K + K PEK +
Sbjct: 10855 IKKPEAPPPKEPE-PEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQ 10913
Query: 586 SPAKEEA---KSPAEAKS-----PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
P K E K P K PE+ P +E K P +EE K E K EK
Sbjct: 10914 VPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPK--VEPKKLEK 10971
Query: 638 AKSPTKEEAKSPEKAKSPE-----KEEAKSPEKAKSPVKAEA---KSPEKAKSPVKAEAK 689
K P E P+ + E K E K PE K P A +PE P +AE K
Sbjct: 10972 VKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKP-EAEVK 11030
Query: 690 SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
+ K P E +P A V K E AK+P KEEA P+ V ++ SP +
Sbjct: 11031 T---IKPPPVEPEPTPIAAPVTVPVVGKKAE-AKAP-KEEAAKPKGPIKGVPKKTPSPIE 11085
Query: 750 AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA 809
A+ + + P + P + ++ KF ++ K + E S S + E +
Sbjct: 11086 AERRKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTE--SEFVGSSAIFECLVS 11143
Query: 810 PEKEIPKKEEVKSPVKEEEK 829
P I + S ++E K
Sbjct: 11144 PSTAITTWMKDGSNIRESPK 11163
Score = 61.6 bits (148), Expect = 4e-09
Identities = 89/345 (25%), Positives = 137/345 (39%), Gaps = 40/345 (11%)
Query: 666 AKSPVKAEAKSPEK---AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
A+ + EA+S + +K E K P+ S V P +A P + P
Sbjct: 8907 ARLEPRGEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTM-PIRAVPP----EEIPPVV 8961
Query: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782
P+ TPE+ K P P++ + +KA VK K AK + +P +
Sbjct: 8962 APPIPLLLPTPEEKKPP-------PKRIEVTKKA----VKKDAKKVVAKPKEMTPRE--- 9007
Query: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA 842
E K P P KA + +KA E +I K KE+E V E +
Sbjct: 9008 EIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKE-----AVYEKKQAV 9062
Query: 843 EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED--- 899
+EK EE D + E + +P EE E E E+K E +E ED
Sbjct: 9063 HKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEE 9122
Query: 900 -KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA-KAKEPSKPAEKKEAAPEKKDT 957
++ E + E +E + +E +V K+ +++ + K P+K EKK P K
Sbjct: 9123 GQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPK--- 9179
Query: 958 KEEKAKKP--EEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
KKP E+ KT + +E+ ++K P K +K S T
Sbjct: 9180 ---VIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRT 9221
Score = 61.2 bits (147), Expect = 5e-09
Identities = 93/439 (21%), Positives = 175/439 (39%), Gaps = 37/439 (8%)
Query: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
A S AE+ + + PAK+ + A+ E ++ ++++ ++ +A+S E
Sbjct: 185 ATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGA 244
Query: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP---EKAKSPVKAEAKSPEKAKSPVKAEA 688
K+P + K ++ +P AK+ +++ SP++ SP + V+A
Sbjct: 245 AGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIR---HSPSPVRH-VRAPT 300
Query: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
SP ++ SP + SP ++ +SP + T + P K+E
Sbjct: 301 PSPVRSVSPAARISTSPIRS-------VRSPLLMRKTQASTVATGPEVPPPWKQEGYVAS 353
Query: 749 KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP--EKAKSPVKEEVKSPEKAKSPLKED 806
+++ + TL S + +T + E R + A S A +
Sbjct: 354 SSEAEMRETTLTT-STQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEAVATG 412
Query: 807 AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK 866
AK +++ K V + V + +V+EP A E+ A T T +E+ K
Sbjct: 413 AKEVKQDADKSAAVATVVAAVDM---ARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRK 469
Query: 867 KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926
E ++ AV K + +AK++E + + K K+ V ++ K EKT
Sbjct: 470 ---------EAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEKT 520
Query: 927 EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE-KPKTEAKAKEDDKTLSKE 985
V K AKAKE +E ++ TK++K E + +TE A + +
Sbjct: 521 FVPKVVISAAKAKE-------QETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAK 573
Query: 986 PSKPKAEKAEKSSSTDQKD 1004
+K + + +T Q+D
Sbjct: 574 STKLETVPGAQEETTTQQD 592
Score = 60.1 bits (144), Expect = 1e-08
Identities = 108/539 (20%), Positives = 219/539 (40%), Gaps = 59/539 (10%)
Query: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556
GEEE PA++ + A+ + E ++ E K +A+S A V+ + +
Sbjct: 195 GEEEV---PAKKTKTIVSTAQ--ISESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQL 249
Query: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP------------AEAKSPEKA 604
K+PP + P K +++SP KA+ A++++ SP A SP ++
Sbjct: 250 PHKTPP--RIPPKPKSRSPTPPSIAAKAQL-ARQQSPSPIRHSPSPVRHVRAPTPSPVRS 306
Query: 605 KSPVKEEAKSPAEA-KSPVKEEAKSPAEVKSPEKAKSPTKEE---AKSPE---------- 650
SP + SP + +SP+ + V + + P K+E A S E
Sbjct: 307 VSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTT 366
Query: 651 --KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKA 708
+ ++ E+ E + + + + A + + A++ VK++A
Sbjct: 367 STQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEAVATGAKEVKQDADKSAAV 426
Query: 709 KSPVK--EEAKSPEKAKSPVKEEAKTP-------EKAKSPVKEEAKSPEKAK---SPEKA 756
+ V + A+ E S V++ A+ + A+ V++EA+ K + +KA
Sbjct: 427 ATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKA 486
Query: 757 KTLDVKS--PEAKTPAKEEARSPADKF-PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
K ++KS E T +E+ ++ E K+ V + V S KAK +++ + E+
Sbjct: 487 KEQELKSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAK---EQETRISEEI 543
Query: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
K+++V +E A+ K P +E+ +++++ +
Sbjct: 544 TKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSY--EKI 601
Query: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
++E ++ V K + + K+++ + + K ++ ++ K EKT ++
Sbjct: 602 MKETRKTVVPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMRKEAEKTALSTIAV 661
Query: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA---KEDDKTLSKEPSKP 989
AKAKE +E +++ + K + K EA A D+ +EP +P
Sbjct: 662 ATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREP 720
Score = 54.3 bits (129), Expect = 6e-07
Identities = 111/484 (22%), Positives = 168/484 (34%), Gaps = 64/484 (13%)
Query: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
E E K AE + ++ SPP KSPE KSP VKSP++ KSP E
Sbjct: 32636 ENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPR-VKSPEAVKSPKRVKSP---EPS 32691
Query: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK-SPTKEEAKSPEKA 652
P E +P ++ P A + + K+ A S E AK + E + K
Sbjct: 32692 HPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEA---SKEIAKLTCVVESSVLRAKE 32748
Query: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712
+ K+ K E A + K E+ E + E + + +
Sbjct: 32749 VTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYV-CEISGEGGTSKTNLQFM 32807
Query: 713 KEEAKSPEKAKSPVKEEAKTPEKAKSPV---KEEAKSPEKAKS-PEKAKTLDVKSPEAKT 768
+ KS + S + E K+ +K K E K+PE S P L + + +
Sbjct: 32808 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 32867
Query: 769 PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS-----P 823
AK ++ + P K+ + K L ED EI K + S
Sbjct: 32868 VAKFAVKATGE--PRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCT 32925
Query: 824 VKEEEKPQEVKVKEPPK--KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA 881
VK K K K E + +T KT E KK ++ + K E
Sbjct: 32926 VKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSE----- 32980
Query: 882 VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
E K EA+ ++K+ KE +KV + E+ K T +
Sbjct: 32981 ---------EIKMSEAKSQEKLAL--KEEASKVLISEEVKKSAATSL------------- 33016
Query: 942 SKPAEKKEAAPEKKDTKEE--KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999
EK EE K + E+ +T A+ K +S + KA + +
Sbjct: 33017 -----------EKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGA 33065
Query: 1000 TDQK 1003
TD K
Sbjct: 33066 TDVK 33069
Score = 50.4 bits (119), Expect = 8e-06
Identities = 81/394 (20%), Positives = 150/394 (38%), Gaps = 30/394 (7%)
Query: 626 AKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685
A S AE+ + + P K+ A+ E + + +K ++ A + + +
Sbjct: 185 ATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGA 244
Query: 686 AEAKSPEKA--KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
A + P K + P K +++SP K + + +++ SP++ ++P
Sbjct: 245 AGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQL-ARQQSPSPIRHSPSPVRHVRAPTPSP 303
Query: 744 AKSPEKAKSPEKAKTLDVKSP--EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801
+S A + V+SP KT A A P + P K+E +++
Sbjct: 304 VRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGP------EVPPPWKQEGYVASSSEA 357
Query: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
++E +I +E + +E +V + A A A+ E K
Sbjct: 358 EMRETTLTTSTQIRTEERWEGRYGVQE---QVTISGAAGAAASVSASASYAAEAVATGAK 414
Query: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
E K++A K AV+ + + E ++ T PA+ +V+++A
Sbjct: 415 EV--KQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEA- 471
Query: 922 PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT-EAKAKEDDK 980
EKT V K KAKE K TKE K E+ T E KE +K
Sbjct: 472 --EKTAVTKVVVAADKAKEQEL----------KSRTKEVITTKQEQMHVTHEQIRKETEK 519
Query: 981 TLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
T + A+ E+ + ++ +K ++ T++
Sbjct: 520 TFVPKVVISAAKAKEQETRISEEITKKQKQVTQE 553
Score = 50.1 bits (118), Expect = 1e-05
Identities = 130/570 (22%), Positives = 208/570 (36%), Gaps = 77/570 (13%)
Query: 328 RTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQD 387
+T+E+EA S ++ ++ Q +E + ++SY+ + AE+++ E + L E
Sbjct: 32501 KTSEMEASSSVRE-VKSQMTETRE----SLSSYEHSAS---AEMKSAALEEKS-LEEKST 32551
Query: 388 LLNVKMALDIEIAAYRKLL---EGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKI 444
+K L I + + EGE R FS +P+V+ K
Sbjct: 32552 TRKIKTTLAARILTKPRSMTVYEGESAR-------FSCDTDGEPVPTVTWL------RKG 32598
Query: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE-----EEAEGGEE 499
+V+ S + V + +++ +E + E E + E ++A E+
Sbjct: 32599 QVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEK 32658
Query: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK--SPAEVKSPEKAKSPAKEE 557
SPP SPE KSP E KSP KSPE K SP E K P +
Sbjct: 32659 AVTSPP--RVKSPEPRVKSP--EAVKSPKRVKSPEPSHPKAVSPTETK-PTPTEKVQHLP 32713
Query: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE 617
+PP+ K EA E+ + AK K +K K + A+
Sbjct: 32714 VSAPPKITQFLKAEASK--EIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSAD 32771
Query: 618 AKSPVK-------EEAKSPAEVKSPEKAKSPTK-----EEAKSPEKAKSPEKEEAKSPEK 665
+K ++ + E+ S E S T + KS + S E KS +K
Sbjct: 32772 GTYELKINNLTESDQGEYVCEI-SGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQK 32830
Query: 666 AKSPV---KAEAKSPEKAKS-PV------KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
K E K+PE S PV S AK VK + P K+
Sbjct: 32831 TTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGE-PRPTAIWTKDG 32889
Query: 716 AKSPEKAKSPVKEEA--------KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
+ K + E+ KT K+ A S + L +K+ +
Sbjct: 32890 KAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKN--SAGSVSSSCKLTIKAIKDT 32947
Query: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK-EDAKAPEKEIPKKEEVKSPVKE 826
K + ++ P+K K+ V+EE+ +K +AK+ EK K+E K + E
Sbjct: 32948 EAQKVSTQKTSEITPQK-KAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE 33006
Query: 827 EEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
E K E K E+ T + E+
Sbjct: 33007 EVKKSAATSLE--KSIVHEEITKTSQASEE 33034
Score = 49.3 bits (116), Expect = 2e-05
Identities = 106/439 (24%), Positives = 173/439 (39%), Gaps = 64/439 (14%)
Query: 565 KSPEKEEAKSPAEVKSP--EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
K+ E E + S EVKS E +S + E + AE KS + ++E++ +
Sbjct: 32501 KTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTT-------- 32552
Query: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA-------KSPEKAKSPVKAEAK 675
+ K+ + K +S T E +S + + E K + S
Sbjct: 32553 -RKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611
Query: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAKTPE 734
+ K+ + + S E S V E ++ ++A+ + ++A+ EKA + +P
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVT-------SPP 32664
Query: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
+ KSP + KSPE KSP++ VKSPE P+ +A SP + P + V
Sbjct: 32665 RVKSP-EPRVKSPEAVKSPKR-----VKSPE---PSHPKAVSPTETKPTPTEKVQHLPVS 32715
Query: 795 SPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEKPQEVKVKEPPKKAEE----EKAPA 849
+P K LK +A KEI K V+S V + +EV + KK +E + +
Sbjct: 32716 APPKITQFLKAEA---SKEIAKLTCVVESSVL---RAKEVTWYKDGKKLKENGHFQFHYS 32769
Query: 850 TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKE 909
T E K + E+ ++ E E E + + EK
Sbjct: 32770 ADGTYELKINNLTES-----------DQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKV 32818
Query: 910 APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP--SKP--AEKKEAAPEKKDTKEEKAKKP 965
+ K D K E T K EP KA EP SKP + D+ + A K
Sbjct: 32819 SKISETKKSDQKTTESTVTRKTEP---KAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKA 32875
Query: 966 EEKPKTEAKAKEDDKTLSK 984
+P+ A +D K +++
Sbjct: 32876 TGEPRPTAIWTKDGKAITQ 32894
Score = 45.8 bits (107), Expect = 2e-04
Identities = 104/529 (19%), Positives = 188/529 (35%), Gaps = 60/529 (11%)
Query: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIV-----EEQTEETQVTEEVT 471
P+ ++ + + + + HI+ E+ K EK+ V+V +EQ +++ E +T
Sbjct: 441 PVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVIT 500
Query: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAK 531
++E+ E +E E+T P +A+ KE ++ + EE +
Sbjct: 501 TKQEQMHVTHEQIRKE----------TEKTFVPKVVISAAKAKEQETRISEEITKKQKQV 550
Query: 532 SPE---KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588
+ E +E + A + AKS E E + ++++ E E K+
Sbjct: 551 TQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVV 610
Query: 589 KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS 648
+ + + K + S +E + E +E+ + AE + T + +
Sbjct: 611 PKVIVATPKVKEQDLV-SRGREGITTKREQVQITQEKMRKEAEKTALSTIAVATAKAKEQ 669
Query: 649 PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA---EAKSPEKAKSPVKEEAKSP 705
++ E + + + K + +A + V A +A+ E + EE+ +
Sbjct: 670 ETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPGHLEESYAQ 729
Query: 706 EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
+ +E S K P + A P VK +A S KT D K
Sbjct: 730 QTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRV---IQAPSETHIKTTDQKGMH 786
Query: 766 AKTPAKE------EARSPADKFPEKA------------KSPVKEEVKSPEKAKSPLKEDA 807
+ K+ E DK P A K+ E A + L+++
Sbjct: 787 ISSQIKKTTDLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKEL 846
Query: 808 KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK 867
A + VK+P KP E +V+ P + TP D+ K EA
Sbjct: 847 SATSSAQKITKSVKAPT---VKPSETRVRAEPTPLPQFPFADTP------DTYKSEA--- 894
Query: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916
VE KKE V + E + E ++ T PA VE+
Sbjct: 895 -----GVEVKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPVEI 938
Score = 43.9 bits (102), Expect = 8e-04
Identities = 97/455 (21%), Positives = 168/455 (36%), Gaps = 54/455 (11%)
Query: 434 THIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE------ 487
TH +++ E + V K +EQ ET+++EE+T+++++ +E +E E
Sbjct: 509 THEQIRKETEKTFVPKVVISAAKAKEQ--ETRISEEITKKQKQVTQEAIRQETEITAASM 566
Query: 488 -------GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
+ E G +EET + + S EK K K A KE+
Sbjct: 567 VVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQ--- 623
Query: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
++ S + K E + K KE K+ + AK+ +E E +
Sbjct: 624 --DLVSRGREGITTKREQVQITQEKM-RKEAEKTALSTIAVATAKAKEQETILRTRETMA 680
Query: 601 PEKAKSPV---KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
+ + V K + AEA + V A A V+ P + EE+ + +
Sbjct: 681 TRQEQIQVTHGKVDVGKKAEAVATV-VAAVDQARVREPREPGH--LEESYAQQTTLEYGY 737
Query: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE-A 716
+E S K P + A P VK P ++P + K+ ++ + +
Sbjct: 738 KERISAAKVAEPPQRPASEPHVVPKAVK-----PRVIQAPSETHIKTTDQKGMHISSQIK 792
Query: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE-EAR 775
K+ + + K P A S K + +A + T KE A
Sbjct: 793 KTTDLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEA---SIAGSAIATLQKELSAT 849
Query: 776 SPADKFPEKAKSPVKEEVKSPEKAK-SPLKE-------DAKAPEKEIPKKEEV-----KS 822
S A K + K+P + ++ +A+ +PL + D E + K+EV +
Sbjct: 850 SSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKKEVGVSITGT 909
Query: 823 PVKEEE----KPQEVKVKEPPKKAEEEKAPATPKT 853
V+EE +E KV E + + P TP T
Sbjct: 910 TVREERFEVLHGREAKVTETARVPAPVEIPVTPPT 944
Score = 38.9 bits (89), Expect = 0.025
Identities = 85/449 (18%), Positives = 170/449 (37%), Gaps = 62/449 (13%)
Query: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK--SPAEVKSPEKAKSPTKEE 645
AKE + A P + VK E + E K KEE K P +V P K K T EE
Sbjct: 31931 AKEALREAAVLYKPAVSTKTVKGEFRLEIEEK---KEERKLRMPYDVPEPRKYKQTTIEE 31987
Query: 646 AK--------SPEKAKSPEKEEAKSPEKA-----KSPVKAEAKSPEKAKSPVKAEAKSPE 692
+ S K +++ + P K K P + E+
Sbjct: 31988 DQRIKQFVPMSDMKWYKKIRDQYEMPGKLDRVVQKRPKRIRLSRWEQFYVMPLPRITDQY 32047
Query: 693 KAKSPVKEEAKSPEKAKSPVKEEAKSPE---------KAKSPVKEEA-----------KT 732
+ K + + ++ + P + SP+ ++ + +E K
Sbjct: 32048 RPKWRIPKLSQDDLEIVRPARRRTPSPDYDFYYRPRRRSLGDISDEELLLPIDDYLAMKR 32107
Query: 733 PEKAKSPVKEEAKSPEKAKSPEKA------KTLDVKSPEAKTPAKEEARSPADKFPEKAK 786
E+ + ++EE + A P ++ +L SP+A +E + D
Sbjct: 32108 TEEERLRLEEELELGFSASPPSRSPPHFELSSLRYSSPQAHVKVEETRK---DFRYSTYH 32164
Query: 787 SPVKEEVKSPEKAKSPLKE-DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
P K E + + + L+E A+A ++ +++ + + ++EE + V + E
Sbjct: 32165 IPTKAEAST---SYAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQ---HLSEY 32218
Query: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905
K+ ++E+K KK ++ ++EE+ E + +ES A + + PT
Sbjct: 32219 KSELDFMSKEEKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPT 32278
Query: 906 -PEKEAPAKVEVKEDAKPKEK----TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
E P ++ +P E+ TE P+ + + PS + ++ + ++ + +
Sbjct: 32279 YIELMRPVSELIRSRPQPAEEYEDDTERRSPTPERTRPRSPSPVSSERSLSRFERSARFD 32338
Query: 961 KAKKPEEKP---KTEAKAKEDDKTLSKEP 986
+ E KT+ ++ + LS++P
Sbjct: 32339 IFSRYESMKAALKTQKTSERKYEVLSQQP 32367
Score = 37.0 bits (84), Expect = 0.095
Identities = 109/602 (18%), Positives = 205/602 (34%), Gaps = 91/602 (15%)
Query: 484 KEEEGGEEEEAEGG---EEETKSPPAEEAAS-----PEKEAKS--------------PVK 521
+EE EEE E G ++SPP E +S P+ K P K
Sbjct: 32109 EEERLRLEEELELGFSASPPSRSPPHFELSSLRYSSPQAHVKVEETRKDFRYSTYHIPTK 32168
Query: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
EA S + A+ E+ + + K ++ + ++E P + E KS + S
Sbjct: 32169 AEA-STSYAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQHLSEYKSELDFMSK 32227
Query: 582 E---KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-------AKSPVKEEAKSPAE 631
E + KS + E E + + + E+ S A + SP E P
Sbjct: 32228 EEKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPTYIELMRPVS 32287
Query: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691
+ + + E + ++ +PE+ +SP SPV +E +S + + + + S
Sbjct: 32288 ELIRSRPQPAEEYEDDTERRSPTPERTRPRSP----SPVSSE-RSLSRFERSARFDIFSR 32342
Query: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA----------KSPVKEEAK----TPEKAK 737
++ + K+ E+ + ++ + + A + P + + K
Sbjct: 32343 YESMKAALKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPT 32402
Query: 738 SPVK-----EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
+ VK E + K + L ++ + T R+ + +A +
Sbjct: 32403 AEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLD 32462
Query: 793 VKSPEKAK-SPLKEDAKAPEKEIPKKEEVKS-PVKEEEKPQEVKVKEPPKKAEEEKAPAT 850
V + + + D + P P+ ++ V +K E++ ++ + +
Sbjct: 32463 VTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETR 32522
Query: 851 PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA----------VEKPKESKV----EAKKEE 896
+ S E + +EEK + KP+ V A+
Sbjct: 32523 ESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSC 32582
Query: 897 AEDKKKVPTPEKEAPAKV------EVKEDAKPKEKTEVAKKEPDD-------AKAKEPSK 943
D + VPT +V K K E++ + D + E +
Sbjct: 32583 DTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQ 32642
Query: 944 PAE-----KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSS 998
AE +K EK T + K PE + K+ K + S EPS PKA ++
Sbjct: 32643 EAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETK 32702
Query: 999 ST 1000
T
Sbjct: 32703 PT 32704
Score = 36.6 bits (83), Expect = 0.12
Identities = 51/193 (26%), Positives = 73/193 (37%), Gaps = 32/193 (16%)
Query: 813 EIPKKEEVKSPVKEEEKPQ-EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871
EI ++E+ +S ++ +P+ E V EP K E +K D + KE K
Sbjct: 1928 EIQQREDFRSVLRRAPEPRPEFHVHEPGKLQFEV---------QKVDRPVDTTETKEVVK 1978
Query: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK--EAPAKVEVKEDAKPKEKTEVA 929
K E+ KV + EE K K T E EA VE+K K + E+
Sbjct: 1979 LK-------RAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELL 2031
Query: 930 KKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989
+K D+ K+ T+EEK EE T K D LS P
Sbjct: 2032 RKTKDELLHWT-------------KELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAP 2078
Query: 990 KAEKAEKSSSTDQ 1002
K + +S + Q
Sbjct: 2079 KIFERIQSQTVGQ 2091
Score = 33.1 bits (74), Expect = 1.4
Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 18/116 (15%)
Query: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE--EKEAKEEEGKEEEG 488
SVS+ K+ IK ++ +E + V ++ +E T + V +EE +K + EE K E
Sbjct: 32932 SVSSSCKLT----IKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA 32987
Query: 489 GEEEEAEGGEEETKSPPAEE-----AASPEKEA-------KSPVKEEAKSPAEAKS 532
+E+ EE +K +EE A S EK S EE ++ AE K+
Sbjct: 32988 KSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKA 33043
Score = 31.6 bits (70), Expect = 4.0
Identities = 30/125 (24%), Positives = 47/125 (37%), Gaps = 21/125 (16%)
Query: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476
P P +PE P IP + K K E ++K ++ E E T + VT
Sbjct: 11002 PEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVE-------PEPTPIAAPVTVPVV- 11053
Query: 477 EAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE 536
G++ EA+ +EE P P K+ SP++ E + EK
Sbjct: 11054 ------------GKKAEAKAPKEEAAKPKGPIKGVP-KKTPSPIEAERRKLRPGSGGEKP 11100
Query: 537 EAKSP 541
++P
Sbjct: 11101 PDEAP 11105
Score = 31.2 bits (69), Expect = 5.2
Identities = 29/110 (26%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEE-EKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
KK+E KS +E E+ + ++ + + AE + P T+ K++ +E A KP V
Sbjct: 31891 KKQEFKSK-EEHERHVQKQIDKTLRMAEILSGTESVPLTQVAKEALREAAVLY---KPAV 31946
Query: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE 924
K V+ ++E KKEE + + PE + ++ED + K+
Sbjct: 31947 STK---TVKGEFRLEIEEKKEERKLRMPYDVPEPRKYKQTTIEEDQRIKQ 31993
>gi|24234699 keratin 19 [Homo sapiens]
Length = 400
Score = 172 bits (437), Expect = 1e-42
Identities = 127/399 (31%), Positives = 196/399 (49%), Gaps = 37/399 (9%)
Query: 20 GGGSLHY-------ALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAAS 72
GGGS+ + A + GG+GG R + SS+ F VS+S S G G
Sbjct: 19 GGGSVRFGPGVAFRAPSIHGGSGG-RGVSVSSARF----------VSSSSSGAYGGGYGG 67
Query: 73 STDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAAL 132
+ D L G +EK +Q LNDR A Y+DKVR LEA N LE +
Sbjct: 68 VLTASDGLLAG------------NEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDW 115
Query: 133 RQQQA-GRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQ 191
Q+Q G S Y ++++R +L ++ L+ ++ R + + E
Sbjct: 116 YQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQAL 175
Query: 192 REEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAA 251
R EA L R E AR DL+ + + L+EE YL+++H+EE+ L GQ+ G
Sbjct: 176 RMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGG---- 231
Query: 252 QAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAM 311
Q+ E A D+ L ++R+Q E A Q+ +E WF R + L+ +T+ +
Sbjct: 232 --QVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQL 289
Query: 312 RSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAEL 371
+ ++ E+T+ RR LQ EL++ S K +LE +E E R A +A Q I ++A+L
Sbjct: 290 QMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQL 349
Query: 372 RNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEE 410
+ + + Q +EYQ L+++K L+ EIA YR LLEG+E
Sbjct: 350 GDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQE 388
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 171 bits (434), Expect = 2e-42
Identities = 101/331 (30%), Positives = 182/331 (54%), Gaps = 10/331 (3%)
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQ--QAGRSAMGELYEREVREMR 154
E+EQ++ LN++FA +IDKVR LE N+ L+ + L++Q + R + L+E+ + +R
Sbjct: 163 EREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLR 222
Query: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
+ + RG+L E ++ + + ++ + +DE +R AE L + A +V
Sbjct: 223 RQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKV 282
Query: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
+LQ KA L +E +LR + E+ ++ I + + D+ S + E+
Sbjct: 283 ELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRN-----LDLDSIIAEV 337
Query: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
+AQ E A +S ++E W++ + + L A + D +R+ ++EI E R +Q +E++
Sbjct: 338 KAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDH 397
Query: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
+K SL+ ++ E R + + + ++ L+ L+ K ++A L+EYQ+L+NVK+A
Sbjct: 398 VKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLA 457
Query: 395 LDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
LD+EIA YRKLLEGEECR+ G G + S+
Sbjct: 458 LDVEIATYRKLLEGEECRLNGEGVGQVNVSV 488
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 171 bits (434), Expect = 2e-42
Identities = 103/335 (30%), Positives = 184/335 (54%), Gaps = 7/335 (2%)
Query: 90 AVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYERE 149
A + EKEQ++ LN++FA +IDKVR LE N+ LE + + L++Q+ RS + L+E
Sbjct: 158 AQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESY 217
Query: 150 VREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEA 209
+ +R + L + + +L+ E+ HL + + +++ ++E R AE AL + A
Sbjct: 218 ITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAA 277
Query: 210 EAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTS 269
+ DL+ L +E +L+ + EE+ Q+ S ++ + + ++ ++
Sbjct: 278 FMNKSDLEANVDTLTQEIDFLKTLYMEEI-----QLLQSHISETSVIVKMDNSRDLNLDG 332
Query: 270 ALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQART 329
+ E++AQ E A +S +E W++ + + + A + D +R+ + EI E R +Q
Sbjct: 333 IIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLK 392
Query: 330 TELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
E+E K+ + LE +E E + +A ++ + + L+ L+ K +MA QL EYQ+L+
Sbjct: 393 AEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELM 452
Query: 390 NVKMALDIEIAAYRKLLEGEECRI--GFGPIPFSL 422
N K+ LDIEIA YR+LLEGEE R+ G GP+ S+
Sbjct: 453 NAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISV 487
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 171 bits (434), Expect = 2e-42
Identities = 98/331 (29%), Positives = 180/331 (54%), Gaps = 10/331 (3%)
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQ--QAGRSAMGELYEREVREMR 154
E+EQ++ LN++FA +IDKVR LE N+ L+ + L++Q + R + L+E+ + +R
Sbjct: 168 EREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLR 227
Query: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
+ + RG+L E ++ + + + + +DE +R AE L + A +V
Sbjct: 228 RQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKV 287
Query: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
+L+ K AL +E +++ E+ ++ + + + D+ S + E+
Sbjct: 288 ELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRN-----LDLDSIIAEV 342
Query: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
+AQ E A +S ++E W++ + + L + A + D +R+ + EI+E R +Q E++
Sbjct: 343 KAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDN 402
Query: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
+K +L+ ++ E R + + + + +L+ L+ K +MA LREYQ+L+N K+A
Sbjct: 403 VKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLA 462
Query: 395 LDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
LD+EIA YRKLLEGEECR+ G GP+ S+
Sbjct: 463 LDVEIATYRKLLEGEECRLSGEGVGPVNISV 493
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 171 bits (434), Expect = 2e-42
Identities = 130/441 (29%), Positives = 212/441 (48%), Gaps = 38/441 (8%)
Query: 4 FGGADALLGAPFAPLHGGG-SLHYALARKGGAGGTRSAAGS---SSGFHSWTRTSVSSVS 59
FGG + FA +GGG Y GG GG R G + GF +
Sbjct: 80 FGGGRS--SCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFGGAGGFGGAGGFGGAGGF 137
Query: 60 ASPSRFRGAGAASSTDSLDTLSN----GPEGCMVAVATSRS------------------- 96
P F G+G SL + G G + V ++S
Sbjct: 138 GGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLLQPLNVEIDPQIGQVKAQ 197
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQ----AGRSAMGELYEREVRE 152
E+EQ++ LN++FA +IDKVR LE N+ LE + L+QQ +G + + L+E +
Sbjct: 198 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENHINY 257
Query: 153 MRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAA 212
+R + + RG+L E +++ + + +++ +DE +R AE L + A
Sbjct: 258 LRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMN 317
Query: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
+V+LQ K AL +E +LR + E+ ++ I + + + +L D+ S +
Sbjct: 318 KVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV---LSMDNNRSL--DLDSIIA 372
Query: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
E+RAQ E A +S ++E ++ +L L A + D +R+ + EI E R +Q E+
Sbjct: 373 EVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEI 432
Query: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
E +K +L+ +E E + + +Q+L A L+ K ++A LR+YQ+L+NVK
Sbjct: 433 EGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVK 492
Query: 393 MALDIEIAAYRKLLEGEECRI 413
+ALD+EIA YRKLLEGEE R+
Sbjct: 493 LALDVEIATYRKLLEGEEYRM 513
>gi|24430190 keratin 15 [Homo sapiens]
Length = 456
Score = 171 bits (433), Expect = 3e-42
Identities = 141/465 (30%), Positives = 215/465 (46%), Gaps = 35/465 (7%)
Query: 3 SFGGADALLGAPFAPL--HGGGSLHYALARKGGAGGTRS---------AAGSSSGFHSWT 51
+FGG G+ A GGGSL G GG+RS ++GS G+
Sbjct: 12 TFGGGSTRGGSLLAGGGGFGGGSL-------SGGGGSRSISASSARFVSSGSGGGYGGGM 64
Query: 52 RTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGY 111
R A G G G G + S +EK +Q LNDR A Y
Sbjct: 65 RVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLL-----SGNEKITMQNLNDRLASY 119
Query: 112 IDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGEL--YEREVREMRGAVLRLGAARGQLRL 169
+DKVR LE N LE + Q+Q S + Y + + E+R ++ ++ L
Sbjct: 120 LDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVIL 179
Query: 170 EQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGY 229
E ++ R + ++E R+ EA L R E AR DL+ + + L EE Y
Sbjct: 180 EIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAY 239
Query: 230 LRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQS 289
L+++H+EE+ E Q+ G Q+ E A D+T L E+R Q E A ++
Sbjct: 240 LKKNHEEEMKEFSSQLAG------QVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDV 293
Query: 290 EEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSEL 349
E WF + + L++ NT+ +++++ EIT+ RR +Q EL++ S K LE +E
Sbjct: 294 EAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAET 353
Query: 350 EDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGE 409
E R+ + Q I L+A+L + EM AQ +EY+ LL++K L+ EIA YR LLEG+
Sbjct: 354 ECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQ 413
Query: 410 ECRI-GFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKE 453
+ ++ G G S G S + HI V+ +VV ++E
Sbjct: 414 DAKMAGIGIREASSGGG---GSSSNFHINVEESVDGQVVSSHKRE 455
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 171 bits (432), Expect = 4e-42
Identities = 100/331 (30%), Positives = 182/331 (54%), Gaps = 10/331 (3%)
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQ--QAGRSAMGELYEREVREMR 154
E+EQ++ LN++FA +IDKVR LE N+ L+ + L++Q + R + L+E+ + +R
Sbjct: 163 EREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLR 222
Query: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
+ + RG+L E ++ + + ++ + +DE +R AE L + A +V
Sbjct: 223 RQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKV 282
Query: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
+LQ KA L +E +LR + E+ ++ I + + D+ S + E+
Sbjct: 283 ELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRN-----LDLDSIIAEV 337
Query: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
+AQ E A +S ++E W++ + + L A + D +R+ ++EI E R +Q +E++
Sbjct: 338 KAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDH 397
Query: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
+K +L+ ++ E R + + + ++ L+ L+ K ++A L+EYQ+L+NVK+A
Sbjct: 398 VKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLA 457
Query: 395 LDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
LD+EIA YRKLLEGEECR+ G G + S+
Sbjct: 458 LDVEIATYRKLLEGEECRLNGEGVGQVNISV 488
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 170 bits (430), Expect = 7e-42
Identities = 101/331 (30%), Positives = 180/331 (54%), Gaps = 10/331 (3%)
Query: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQ--QAGRSAMGELYEREVREMR 154
E+EQ++ LN++FA +IDKVR LE N+ LE + L++Q + R + L+E+ + +R
Sbjct: 163 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLR 222
Query: 155 GAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARV 214
+ + RG+L E + + + + + +DE +R AE L + A +V
Sbjct: 223 RQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKV 282
Query: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
+LQ KA L +E +LR + E+ ++ I + + D+ S + E+
Sbjct: 283 ELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRN-----LDLDSIIAEV 337
Query: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
+AQ E A +S ++E W++ + + L A + D +R+ ++EI E R +Q +E++
Sbjct: 338 KAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDH 397
Query: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
+K +L+ ++ E R + + + ++ L+ L+ K ++A L+EYQ+L+NVK+A
Sbjct: 398 VKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLA 457
Query: 395 LDIEIAAYRKLLEGEECRI---GFGPIPFSL 422
LD+EIA YRKLLEGEECR+ G G + S+
Sbjct: 458 LDVEIATYRKLLEGEECRLNGEGVGQVNISV 488
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 170 bits (430), Expect = 7e-42
Identities = 164/604 (27%), Positives = 265/604 (43%), Gaps = 63/604 (10%)
Query: 456 IVEEQTEET--------QVTEEVTEEEEKEAKEEEGKEE-EGGEEEEAEGGEEETKSPPA 506
+V + EET + ++ E++E +++G E+ + GE +E ++E
Sbjct: 91 LVRDAMEETTDWIYGFFSLLSDIISSEDEE--DDDGDEDTDKGEIDEPPLRKKEIHKDKT 148
Query: 507 EEAASPEKEAKSPV--KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
E+ PE++ ++ V KE+ K + + EK E K+ + K +K K K AK +A
Sbjct: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKA 208
Query: 565 KSPEKEEAKSPAEVKS--PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
K+ EK E K+ EVK EK K A AK K+P K K KE+ + A +K
Sbjct: 209 KTAEKSEEKTKKEVKGGKQEKVKQTA---AKVKEVQKTPSKPKE--KEDKEKAAVSKHEQ 263
Query: 623 KEE------------------AKSPAEVKSP---EKAKSPTKEEAKSPEKAKSPEKEEAK 661
K++ +SPA + P E+A PT EK +K E K
Sbjct: 264 KDQYAFCRYMIDIFVHGDLKPGQSPA-IPPPLPTEQASRPTPASPALEEKEGEKKKAEKK 322
Query: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
+ K K + K + ++ + E K P KA + K +A + E+ + +K
Sbjct: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKK 382
Query: 722 AKSPVKEEAKTPEKAKSPVK--EEAKSPEKAKSPEKAKTLDVKSPEAKTP--AKEEARSP 777
K P + E +K + K E AKSP+K S K + K+ AK A ++
Sbjct: 383 TKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAV 442
Query: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
K EK V++E++ + K+ + +KE K +E K P +EK E K E
Sbjct: 443 PGKKEEKTTKTVEQEIRKEKSGKT----SSILKDKEPIKGKEEKVPASLKEKEPETKKDE 498
Query: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
KA +E P P+ + KK+ K E KKEA KP + EK V+ K+ V+ +K +
Sbjct: 499 KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEA-KPAISEK----VQIHKQDIVKPEKTVS 553
Query: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
K + ++ +E KP +K E ++EP K +P KP K + +
Sbjct: 554 HGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKP-KPTPKGTSEVTESGK 612
Query: 958 KEEKAKKPEEKPKTEAKAKEDDKTLSKEPS-----KPKAEKAEKSSS--TDQKDSKPPEK 1010
K+ + + E K K + K ++K +++ S KAEK + S D SK ++
Sbjct: 613 KKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
Query: 1011 ATED 1014
TED
Sbjct: 673 GTED 676
Score = 151 bits (381), Expect = 3e-36
Identities = 145/557 (26%), Positives = 235/557 (42%), Gaps = 67/557 (12%)
Query: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
K + K + E E+ +T+VT + E+ +++ +E+E E++ +E+ E E+ P
Sbjct: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEK----P 196
Query: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
+ A +K+AK+ K E K+ E K ++E+ K A K E K+P+K + K E
Sbjct: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA-AKVKEVQKTPSKPKEKEDKEK 255
Query: 565 KSPEKEEAKS-----------------------------PAEVKSPEKAKSPAKEEA--- 592
+ K E K P E S SPA EE
Sbjct: 256 AAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE 315
Query: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652
K AE K + K KE+ K +E ++ + E K P + ++ +A + +
Sbjct: 316 KKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE 375
Query: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEK----AKSPVKAEAKSPEKAKSPVKEEAKSPEKA 708
K + ++ K P + + P + + EK AKSP K + +K E AK A
Sbjct: 376 KKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGA 435
Query: 709 KSPVKE-EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
S K K EK V++E + + K+ + K P K K + +L K PE K
Sbjct: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495
Query: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP--EKEIPKKEEVKSPVK 825
K+E S A K E P + + K EK + +K++AK EK K+++ P K
Sbjct: 496 ---KDEKMSKAGK--EVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK 550
Query: 826 --EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
KP+E K ++ KA KT + K +KK E ++E P K +
Sbjct: 551 TVSHGKPEE-------KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIK--------TD 595
Query: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD-AKAKEPS 942
KPK + + KKK EKE+ K ++K + K T + + KA++P+
Sbjct: 596 KPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
Query: 943 KPAEKKEAAPEKKDTKE 959
+ ++ E P K KE
Sbjct: 656 RVSKDVEDVPASKKAKE 672
Score = 142 bits (358), Expect = 2e-33
Identities = 148/516 (28%), Positives = 225/516 (43%), Gaps = 46/516 (8%)
Query: 532 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591
S ++E+ + E + P +++ + + EK E K +V EK K K
Sbjct: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175
Query: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651
K E K+ K K KE+ E K+ KE+ K+ K+ EK++ TK+E K ++
Sbjct: 176 EKEKPEKKATHKEKIEKKEKP----ETKTLAKEQKKA----KTAEKSEEKTKKEVKGGKQ 227
Query: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVK---------EEA 702
K ++ AK E K+P K + K +K K+ V + + A +
Sbjct: 228 EKV-KQTAAKVKEVQKTPSKPKEKE-DKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPG 285
Query: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA---KSPEKAKTL 759
+SP E+A P A ++E+ +KA+ V E K EK K EK +
Sbjct: 286 QSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAI 345
Query: 760 DVKSPEAKTPAK-EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED---AKAPEKEIP 815
DV E K P K E + K +A + E+ + +K K P + + K EK+
Sbjct: 346 DV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
Query: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEEE------KAPATPKTEEKKDSKKEEAPKKEA 869
E KSP KE P + +VK ++A+EE K K EEK E+ +KE
Sbjct: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
Query: 870 PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929
K+ K KE KV A +E E + K EK + A EVK KP + +
Sbjct: 463 SGKTSSILKDKEPIKGKEEKVPASLKEKEPETK--KDEKMSKAGKEVKP--KPPQ-LQGK 517
Query: 930 KKEPDDAKAKEPSKPAEKKEAAPEKKD-TKEEKAK---KPEEKPKTEAKAKEDDKTLSKE 985
K+E + + K+ +KPA ++ K+D K EK KPEEK + KA +KT +
Sbjct: 518 KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
Query: 986 PSKPKAEKAEKSSSTDQKDS-KPPEKATEDKAAKGK 1020
P+K KAE E+ + + D KP K T + GK
Sbjct: 578 PTK-KAEHREREPPSIKTDKPKPTPKGTSEVTESGK 612
Score = 124 bits (311), Expect = 5e-28
Identities = 133/535 (24%), Positives = 214/535 (40%), Gaps = 62/535 (11%)
Query: 428 KIPSVSTHI-KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE 486
KI + TH K K +EK++ EK EK+ E+ ++ + + +E+K+AK E EE
Sbjct: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE 216
Query: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS------ 540
+ ++E +GG++E A + +K P ++E K A E+++ +
Sbjct: 217 K--TKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI 274
Query: 541 --------------------PAEVKSPEKAKSPAKEEA---KSPPEAKSPEKEEAKSPAE 577
P E S SPA EE K E K + + K +
Sbjct: 275 DIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKED 334
Query: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
+K + ++ E K P +A ++ + +A + + K ++ K PAEV+ P+
Sbjct: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
Query: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA-EAKSPEKAKS 696
K KE K E AKSP+KE + +K AK A S KA K EK
Sbjct: 395 KKQEKKE--KHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTK 452
Query: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKS---PVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
V++E + + K+ + K P K K P + K PE K +A K K P
Sbjct: 453 TVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPP 512
Query: 754 E-KAKTLDVKSPEAKTPAKEEARSPADKF------PEKAKSPVKEEVKSPEKAKS-PLKE 805
+ + K + P+ K AK PEK S K E K ++ K+ +++
Sbjct: 513 QLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEK 572
Query: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEV------------KVKEPPKKAEEEKAPATPKT 853
AK + + E + P + +KP+ K E +K +EKA
Sbjct: 573 TAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLR 632
Query: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK 908
EEK ++KE K +K V K E +KK + + PT +K
Sbjct: 633 EEKVSTRKESLQLHNVTK----AEKPARVSKDVEDVPASKKAKEGTEDVSPTKQK 683
Score = 110 bits (276), Expect = 5e-24
Identities = 130/503 (25%), Positives = 208/503 (41%), Gaps = 66/503 (13%)
Query: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIV-----EEQTEETQVTEEVTEEEEKEA 478
E + K T K ++K K EKSE++T +E+ ++T + ++ +
Sbjct: 188 EKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKP 247
Query: 479 KEEEGKEEEGGEEEEAE---------------GGEEETKSP------PAEEAASP----- 512
KE+E KE+ + E + G + +SP P E+A+ P
Sbjct: 248 KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASP 307
Query: 513 ---EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV--------KSPEKAKSPAKEEAKSP 561
EKE + K E K +E K EKE+ K +E K P KA + K
Sbjct: 308 ALEEKEGEKK-KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 562 PEA--KSPEKEE----AKSPAEVKSPEKAKSPAKEE----AKSPAEAKS--PEKAKSPVK 609
+A K EK+E K PAEV+ P+ K KE+ AKSP + S +K
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Query: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
E AK A S +K+ E K+ + + ++E + +KE K E+ K P
Sbjct: 427 ERAKEEIGAVS-IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE-KVP 484
Query: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV-KE 728
+ K PE K ++A K K P + + K EK + +K+EAK K + K+
Sbjct: 485 ASLKEKEPETKKDEKMSKAGKEVKPKPP-QLQGKKEEKPEPQIKKEAKPAISEKVQIHKQ 543
Query: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788
+ PEK S K E K ++ K+ KT P+ A+ R P +K K
Sbjct: 544 DIVKPEKTVSHGKPEEKVLKQVKAVTIEKT---AKPKPTKKAEHREREPPSIKTDKPKPT 600
Query: 789 VK--EEVKSPEKAKSPLKEDAKAPEKEIPK-KEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
K EV K K+ + E + ++ +EE S KE + V E P + ++
Sbjct: 601 PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD 660
Query: 846 KAPATPKTEEKKDSKKEEAPKKE 868
P +++ K+ ++ +P K+
Sbjct: 661 -VEDVPASKKAKEGTEDVSPTKQ 682
Score = 106 bits (264), Expect = 1e-22
Identities = 142/578 (24%), Positives = 238/578 (41%), Gaps = 96/578 (16%)
Query: 323 RQLQARTTELEALKSTKDSLERQRSELEDRHQADI-----------ASYQEAIQQLDAEL 371
R++Q + T E K + E+++ E + H+ I A Q+ + +
Sbjct: 156 RKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSE 215
Query: 372 RNTKWEM-----------AAQLREYQDLLNV-KMALDIEIAAYRKLLEGEE---CRI--- 413
TK E+ AA+++E Q + K D E AA K + ++ CR
Sbjct: 216 EKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMID 275
Query: 414 ---------GFGP-IPFSLPEGLPKIPS-VSTHIKVKSEEKIKVVEKSEKETVIVEEQTE 462
G P IP LP P+ S ++ K EK K +K ET E+
Sbjct: 276 IFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEK--- 332
Query: 463 ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKE 522
E++ ++ EKE + K+E G AS K+ +
Sbjct: 333 -----EDIKKKSEKETAIDVEKKEPG--------------------KASETKQGTVKIAA 367
Query: 523 EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582
+A + + K + ++ K PAEV+ P+ K KE+ P AKSP+KE + V S +
Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP--AKSPKKEHS-----VPSDK 420
Query: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642
+ K+ E AK A S +KA P K+E K+ + +++E + S K K P
Sbjct: 421 QVKAKT-ERAKEEIGAVSIKKA-VPGKKEEKTTKTVEQEIRKE--KSGKTSSILKDKEPI 476
Query: 643 K-EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
K +E K P K E E K + +K+ + + K P+ + K EK + +K+E
Sbjct: 477 KGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQ-------LQGKKEEKPEPQIKKE 529
Query: 702 AKSPEKAKSPV-KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
AK K + K++ PEK S K E K ++ K+ E+ P+ K KA+ +
Sbjct: 530 AKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTK---KAEHRE 586
Query: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVK-EEVKSPEKA-KSPLKEDAKAPEKE---IP 815
+ P KT + + E K + E +S EKA L+E+ + KE +
Sbjct: 587 REPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLH 646
Query: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT 853
+ + P + + ++V + K+ E+ +P K+
Sbjct: 647 NVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKS 684
Score = 71.6 bits (174), Expect = 3e-12
Identities = 95/403 (23%), Positives = 164/403 (40%), Gaps = 45/403 (11%)
Query: 301 SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360
+E A T A + +E+ E ++ + T+E + K K+ +++ +SE E +
Sbjct: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETK--KKEKEDIKK-KSEKETAIDVEKKEP 352
Query: 361 QEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPF 420
+A + ++ A + + +D K ++E +K E +E + P
Sbjct: 353 GKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ-EKKEKHVE----PA 407
Query: 421 SLPEGLPKIPSVSTHIKVKSE---EKIKVV--------EKSEKETVIVEEQT--EETQVT 467
P+ +PS +K K+E E+I V +K EK T VE++ E++ T
Sbjct: 408 KSPKKEHSVPS-DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT 466
Query: 468 EEVTEEEEK-EAKEEE------GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520
+ +++E + KEE+ KE E ++E+ +E K P + E++ + +
Sbjct: 467 SSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQI 526
Query: 521 KEEAKSPAEAK---------SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE 571
K+EAK K PEK + E K ++ K+ E+ P K E E
Sbjct: 527 KKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRE 586
Query: 572 AKSPA----EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
+ P+ + K K S E K E E S K + K E K ++E+
Sbjct: 587 REPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKE---SKEKADMKHLREEKVSTRKESL 643
Query: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
V EK +K+ P K+ E E SP K KSP+
Sbjct: 644 QLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 169 bits (428), Expect = 1e-41
Identities = 128/432 (29%), Positives = 203/432 (46%), Gaps = 38/432 (8%)
Query: 4 FGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPS 63
FGG + G FA +GGG GG G S G + GF V P
Sbjct: 81 FGGGRSSCG--FAGGYGGGFGGSYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPG 138
Query: 64 RFRGAGAASSTDSLDTLSNGPEGCMVAVATSRS-------------------EKEQLQAL 104
F G G G G + V ++S E+EQ++ L
Sbjct: 139 SFGGPGGFGP--------GGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTL 190
Query: 105 NDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGR--SAMGELYEREVREMRGAVLRLGA 162
N++FA +IDKVR LE N+ LE + L+QQ G S++ +E + + + L
Sbjct: 191 NNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLG 250
Query: 163 ARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQA 222
RG L E + + + + +++ +DE +R AE L + A +V+LQ K +
Sbjct: 251 ERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDS 310
Query: 223 LQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKC-DVTSALREIRAQLEGH 281
L +E +LR ++ E+ ++ + + D +C D+ S + E+RAQ E
Sbjct: 311 LTDEVSFLRTLYEMELSQMQSHASDTSVVLSM------DNNRCLDLGSIIAEVRAQYEEI 364
Query: 282 AVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDS 341
A +S ++E ++ +L L A + D +R+ + EI E R +Q E+E +K +
Sbjct: 365 AQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNAN 424
Query: 342 LERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAA 401
L+ +E E R + + +Q L L+ K ++A LR+YQ+L+NVK+ALD+EIA
Sbjct: 425 LQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIAT 484
Query: 402 YRKLLEGEECRI 413
YRKLLEGEECR+
Sbjct: 485 YRKLLEGEECRM 496
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 168 bits (425), Expect = 3e-41
Identities = 111/342 (32%), Positives = 175/342 (51%), Gaps = 12/342 (3%)
Query: 96 SEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAA--LRQQQAGRSAMGELYEREVREM 153
+EK +Q LNDR A Y++KVR LE N LE + L+Q A Y + + E+
Sbjct: 103 NEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEEL 162
Query: 154 RGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAAR 213
R +L ++ LE ++ R + ++E R+ EA L R E ++
Sbjct: 163 RDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSK 222
Query: 214 VDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALRE 273
DL+ + ++L EE Y++++H+EE+ E Q+ G Q+ E D+T L E
Sbjct: 223 TDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVG------QVNVEMDATPGIDLTRVLAE 276
Query: 274 IRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELE 333
+R Q E A ++ +EEWF + L++ NT +++++ EITE RR LQ EL+
Sbjct: 277 MREQYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQ 336
Query: 334 ALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKM 393
+ S K LE +E E R+ + Q I ++A+L + EM Q +EY+ LL++K
Sbjct: 337 SQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKT 396
Query: 394 ALDIEIAAYRKLLEGEECR-IGFGPIPFSLPEGLPKIPSVST 434
L+ EIA YR LLEG++ + IGF P S P+ SV+T
Sbjct: 397 RLEQEIATYRSLLEGQDAKMIGF---PSSAGSVSPRSTSVTT 435
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 166 bits (419), Expect = 1e-40
Identities = 103/324 (31%), Positives = 172/324 (53%), Gaps = 5/324 (1%)
Query: 90 AVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYERE 149
A + EKEQ+++LN RFA +IDKVR LE N+ LE + + Q+ S + L+
Sbjct: 116 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGY 175
Query: 150 VREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEA 209
+ +R + A G+L E H+ E + +++ ++E R AE L + A
Sbjct: 176 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCA 235
Query: 210 EAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTS 269
+ DL+ +AL EE +LRR ++EE+ L I S + +RD ++
Sbjct: 236 YLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHI--SDTSVIVKMDNSRDL---NMDC 290
Query: 270 ALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQART 329
+ EI+AQ + A +S ++E W+R + + + + + +R +EEI E R +Q T
Sbjct: 291 IIAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLT 350
Query: 330 TELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
E+E K + LE +E E + +A ++ + + +L+ L+ K +MA L+EYQ+++
Sbjct: 351 AEIENAKCQRAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVM 410
Query: 390 NVKMALDIEIAAYRKLLEGEECRI 413
N K+ LDIEIA YR+LLEGEE R+
Sbjct: 411 NSKLGLDIEIATYRRLLEGEEHRL 434
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 165 bits (417), Expect = 2e-40
Identities = 98/324 (30%), Positives = 172/324 (53%), Gaps = 5/324 (1%)
Query: 90 AVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYERE 149
A + EKEQ+++LN RFA +IDKVR LE N+ LE + + ++ +S + L+E
Sbjct: 99 AQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGY 158
Query: 150 VREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEA 209
+ +R + A G+L E H+ E + +++ ++E R AE AL + A
Sbjct: 159 IETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCA 218
Query: 210 EAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTS 269
+ DL+ +AL +E +LRR ++EE+ L I + + ++ ++
Sbjct: 219 YLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVV-----VKLDNSRDLNMDC 273
Query: 270 ALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQART 329
+ EI+AQ + +S ++E W+R + + + + + +R +EEI E R +Q T
Sbjct: 274 IIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLT 333
Query: 330 TELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
E+E K LE ++ E + +A ++ + + +L+ L+ K +MA +REYQ+++
Sbjct: 334 AEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVM 393
Query: 390 NVKMALDIEIAAYRKLLEGEECRI 413
N K+ LDIEIA YR+LLEGEE R+
Sbjct: 394 NSKLGLDIEIATYRRLLEGEEQRL 417
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.296 0.116 0.299
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,903,633
Number of Sequences: 37866
Number of extensions: 2732499
Number of successful extensions: 133019
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1782
Number of HSP's successfully gapped in prelim test: 2525
Number of HSP's that attempted gapping in prelim test: 15715
Number of HSP's gapped (non-prelim): 35982
length of query: 1020
length of database: 18,247,518
effective HSP length: 112
effective length of query: 908
effective length of database: 14,006,526
effective search space: 12717925608
effective search space used: 12717925608
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.