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Search of human proteins with 31745180
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31745180 aryl hydrocarbon receptor nuclear translocator-like
2 [Homo sapiens]
(636 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 1274 0.0
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 572 e-163
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 572 e-163
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 564 e-160
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 298 1e-80
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 297 2e-80
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 280 3e-75
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 198 1e-50
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 144 2e-34
gi|4758010 clock [Homo sapiens] 144 2e-34
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 137 4e-32
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 137 4e-32
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 130 5e-30
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 121 2e-27
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 119 7e-27
gi|21614542 single-minded homolog 1 [Homo sapiens] 119 8e-27
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 115 9e-26
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 115 9e-26
gi|12707562 period 2 [Homo sapiens] 109 7e-24
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 107 3e-23
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 105 1e-22
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 105 1e-22
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 103 5e-22
gi|8567388 period 3 [Homo sapiens] 85 2e-16
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 84 5e-16
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 81 3e-15
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 81 3e-15
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 74 4e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 74 4e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 74 4e-13
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 1274 bits (3296), Expect = 0.0
Identities = 636/636 (100%), Positives = 636/636 (100%)
Query: 1 MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPS 60
MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPS
Sbjct: 1 MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPS 60
Query: 61 QSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRR 120
QSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRR
Sbjct: 61 QSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRR 120
Query: 121 DKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDN 180
DKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDN
Sbjct: 121 DKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDN 180
Query: 181 ELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVK 240
ELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVK
Sbjct: 181 ELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVK 240
Query: 241 EQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCL 300
EQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCL
Sbjct: 241 EQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCL 300
Query: 301 PNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN 360
PNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN
Sbjct: 301 PNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN 360
Query: 361 SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKH 420
SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKH
Sbjct: 361 SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKH 420
Query: 421 KAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGE 480
KAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGE
Sbjct: 421 KAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGE 480
Query: 481 ASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS 540
ASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS
Sbjct: 481 ASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS 540
Query: 541 PTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFD 600
PTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFD
Sbjct: 541 PTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFD 600
Query: 601 ALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 636
ALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL
Sbjct: 601 ALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 636
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 572 bits (1475), Expect = e-163
Identities = 314/648 (48%), Positives = 420/648 (64%), Gaps = 48/648 (7%)
Query: 14 LREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKL 73
+ ++ I+ +S +SPG S + + RKRKGS +D +S + T+K
Sbjct: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQES-MDTDK----- 54
Query: 74 SQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAM 133
R+E EHQ ++K REAHSQ EKRRRDKMN+ I+EL+++
Sbjct: 55 ----------------DDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASL 98
Query: 134 IPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGF 193
+P CN M+RKLDKLTVLRMAVQH+++L+G TN Y +NY+P+FL D+EL+HLIL+ A+GF
Sbjct: 99 VPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGF 158
Query: 194 LFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREK 253
LFVVGC+RGKILFVS+SV KILNY Q L GQSLFD+LHPKD+AKVKEQLSS D +PRE+
Sbjct: 159 LFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRER 218
Query: 254 LIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPN--SKKKEHRKF 311
LIDAKTGL V +++ G +R+ SG+RRSFFCR+K + SVK E P+ SKKK+ + F
Sbjct: 219 LIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSF 278
Query: 312 YTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN-SGEINVKPTE 370
TIH TGYL+SWPP +G++E+ + N +CLVAIGRL ++VPQ +GEI VK E
Sbjct: 279 CTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME 338
Query: 371 FITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKI 430
+++R A++GKFV+VDQRATAIL YLPQELLGTSCYEYFHQDD +L + H+ VLQ++EKI
Sbjct: 339 YVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKI 398
Query: 431 LTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGH-SEPGEASFLPCSSQ 489
T+ YKF+ KDGSF+TL+S+WFSF NPWTKE+EYIVS NT+VL + E G+ +F ++
Sbjct: 399 TTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
Query: 490 ---------SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS 540
S E +++ +VPG+ GT GAG IG IA EI+++ R++ SS S
Sbjct: 459 PHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGS 518
Query: 541 PTGLMKDTHTVNCRSMSNKELF----PPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQ 596
+ T + S K++ P PS G L Q +L +
Sbjct: 519 SPLNITSTPPPDASSPGGKKILNGGTPDIPSS-GLLSGQAQENPGYPYSDSSSILGENPH 577
Query: 597 LDFDALCD--------NDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 636
+ D + + ND+ AMA M+ LEA+ GLG P DFSD+ W L
Sbjct: 578 IGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 572 bits (1475), Expect = e-163
Identities = 314/648 (48%), Positives = 420/648 (64%), Gaps = 48/648 (7%)
Query: 14 LREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKL 73
+ ++ I+ +S +SPG S + + RKRKGS +D +S + T+K
Sbjct: 1 MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQES-MDTDK----- 54
Query: 74 SQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAM 133
R+E EHQ ++K REAHSQ EKRRRDKMN+ I+EL+++
Sbjct: 55 ----------------DDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASL 98
Query: 134 IPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGF 193
+P CN M+RKLDKLTVLRMAVQH+++L+G TN Y +NY+P+FL D+EL+HLIL+ A+GF
Sbjct: 99 VPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGF 158
Query: 194 LFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREK 253
LFVVGC+RGKILFVS+SV KILNY Q L GQSLFD+LHPKD+AKVKEQLSS D +PRE+
Sbjct: 159 LFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRER 218
Query: 254 LIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPN--SKKKEHRKF 311
LIDAKTGL V +++ G +R+ SG+RRSFFCR+K + SVK E P+ SKKK+ + F
Sbjct: 219 LIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSF 278
Query: 312 YTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN-SGEINVKPTE 370
TIH TGYL+SWPP +G++E+ + N +CLVAIGRL ++VPQ +GEI VK E
Sbjct: 279 CTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME 338
Query: 371 FITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKI 430
+++R A++GKFV+VDQRATAIL YLPQELLGTSCYEYFHQDD +L + H+ VLQ++EKI
Sbjct: 339 YVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKI 398
Query: 431 LTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGH-SEPGEASFLPCSSQ 489
T+ YKF+ KDGSF+TL+S+WFSF NPWTKE+EYIVS NT+VL + E G+ +F ++
Sbjct: 399 TTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
Query: 490 ---------SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS 540
S E +++ +VPG+ GT GAG IG IA EI+++ R++ SS S
Sbjct: 459 PHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGS 518
Query: 541 PTGLMKDTHTVNCRSMSNKELF----PPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQ 596
+ T + S K++ P PS G L Q +L +
Sbjct: 519 SPLNITSTPPPDASSPGGKKILNGGTPDIPSS-GLLSGQAQENPGYPYSDSSSILGENPH 577
Query: 597 LDFDALCD--------NDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 636
+ D + + ND+ AMA M+ LEA+ GLG P DFSD+ W L
Sbjct: 578 IGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL 625
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 564 bits (1453), Expect = e-160
Identities = 298/567 (52%), Positives = 392/567 (69%), Gaps = 26/567 (4%)
Query: 95 RVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAV 154
R+E EHQ ++K REAHSQ EKRRRDKMN+ I+EL++++P CN M+RKLDKLTVLRMAV
Sbjct: 17 RLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAV 76
Query: 155 QHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKI 214
QH+++L+G TN Y +NY+P+FL D+EL+HLIL+ A+GFLFVVGC+RGKILFVS+SV KI
Sbjct: 77 QHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKI 136
Query: 215 LNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRV 274
LNY Q L GQSLFD+LHPKD+AKVKEQLSS D +PRE+LIDAKTGL V +++ G +R+
Sbjct: 137 LNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRL 196
Query: 275 YSGSRRSFFCRIKSCKISVKEEHGCLPN--SKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
SG+RRSFFCR+K + SVK E P+ SKKK+ + F TIH TGYL+SWPP +G++E
Sbjct: 197 CSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDE 256
Query: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQN-SGEINVKPTEFITRFAVNGKFVYVDQRATAI 391
+ + N +CLVAIGRL ++VPQ +GEI VK E+++R A++GKFV+VDQRATAI
Sbjct: 257 DNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAI 316
Query: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451
L YLPQELLGTSCYEYFHQDD +L + H+ VLQ++EKI T+ YKF+ KDGSF+TL+S+W
Sbjct: 317 LAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRW 376
Query: 452 FSFTNPWTKELEYIVSVNTLVLGH-SEPGEASFLPCSSQ---------SSEESSRQSCMS 501
FSF NPWTKE+EYIVS NT+VL + E G+ +F ++ S E +++ +
Sbjct: 377 FSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPT 436
Query: 502 VPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKEL 561
VPG+ GT GAG IG IA EI+++ R++ SS S + T + S K++
Sbjct: 437 VPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKI 496
Query: 562 F----PPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCD--------NDDTA 609
P PS G L Q +L + + D + + ND+ A
Sbjct: 497 LNGGTPDIPSS-GLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAA 555
Query: 610 MAAFMNYLEAEGGLGDPGDFSDIQWTL 636
MA M+ LEA+ GLG P DFSD+ W L
Sbjct: 556 MAVIMSLLEADAGLGGPVDFSDLPWPL 582
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 298 bits (762), Expect = 1e-80
Identities = 161/386 (41%), Positives = 238/386 (61%), Gaps = 14/386 (3%)
Query: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
K + RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G
Sbjct: 86 KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 145
Query: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223
N+ +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN Q+
Sbjct: 146 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283
G +L+D +HP DV K++EQLS+ + + +++D KTG V R+ GSRRSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 264
Query: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
CR++ SV + C S K F +HCTGY+++WPP V + +
Sbjct: 265 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 324
Query: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV-KPTEFITRFAVNGKFVYVDQRATAI 391
+ S F CLVAIGRLQ P + NV +PTEFI+R + G F +VD R A
Sbjct: 325 DDPEAGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 383
Query: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451
+GY PQELLG + E+ H +D L D + V++ K ++L+ ++FR+K+ ++ +++
Sbjct: 384 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 443
Query: 452 FSFTNPWTKELEYIVSVNTLVLGHSE 477
F+F NP++ E+EYI+ NT V S+
Sbjct: 444 FTFQNPYSDEIEYIICTNTNVKNSSQ 469
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 297 bits (761), Expect = 2e-80
Identities = 161/386 (41%), Positives = 238/386 (61%), Gaps = 14/386 (3%)
Query: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
K + RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G
Sbjct: 71 KERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 130
Query: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223
N+ +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN Q+
Sbjct: 131 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
Query: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283
G +L+D +HP DV K++EQLS+ + + +++D KTG V R+ GSRRSF
Sbjct: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 249
Query: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
CR++ SV + C S K F +HCTGY+++WPP V + +
Sbjct: 250 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 309
Query: 333 ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV-KPTEFITRFAVNGKFVYVDQRATAI 391
+ S F CLVAIGRLQ P + NV +PTEFI+R + G F +VD R A
Sbjct: 310 DDPEAGQGSKF-CLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVAT 368
Query: 392 LGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQW 451
+GY PQELLG + E+ H +D L D + V++ K ++L+ ++FR+K+ ++ +++
Sbjct: 369 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 428
Query: 452 FSFTNPWTKELEYIVSVNTLVLGHSE 477
F+F NP++ E+EYI+ NT V S+
Sbjct: 429 FTFQNPYSDEIEYIICTNTNVKNSSQ 454
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 280 bits (716), Expect = 3e-75
Identities = 152/398 (38%), Positives = 238/398 (59%), Gaps = 24/398 (6%)
Query: 92 SGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLR 151
SG +D + + K RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LR
Sbjct: 48 SGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILR 107
Query: 152 MAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSV 211
MAV H++S++G N Y+PSFL + EL+HLIL+ A+GFLFVV E G++++VS SV
Sbjct: 108 MAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSV 167
Query: 212 SKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGR 271
+ +LN Q+ G +L++ +HP DV K++EQL + + S +++D KTG V
Sbjct: 168 TPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEGQQSS 226
Query: 272 TRVYSGSRRSFFCRIKS-------------CKISVKEEHGCLPNSKKKEHRKFYTIHCTG 318
R+ GSRRSF CR++ + + +G P K+ ++ +HCTG
Sbjct: 227 MRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGP--VKEGEAQYAVVHCTG 284
Query: 319 YLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQ----PYIVPQNSGEINVKPTEFITR 374
Y+++WPP + + EE S + CLVAIGRLQ P + N + PTEF++R
Sbjct: 285 YIKAWPPAGMTIPEEDADVGQGSKY-CLVAIGRLQVTSSPVCMDMNGMSV---PTEFLSR 340
Query: 375 FAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDS 434
+G +VD R +++GY PQ+LLG E+ H +D ++L + + V++ K ++L+
Sbjct: 341 HNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVM 400
Query: 435 YKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLV 472
Y+FR K+ ++ +++ F+F NP++ E+EYI+ NT V
Sbjct: 401 YRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNV 438
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 198 bits (503), Expect = 1e-50
Identities = 104/241 (43%), Positives = 151/241 (62%), Gaps = 12/241 (4%)
Query: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
K + RE HS+ E+RRR+KM I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G
Sbjct: 86 KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 145
Query: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223
N+ +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN Q+
Sbjct: 146 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283
G +L+D +HP DV K++EQLS+ + + +++D KTG V R+ GSRRSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 264
Query: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332
CR++ SV + C S K F +HCTGY+++WPP V + +
Sbjct: 265 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 324
Query: 333 E 333
+
Sbjct: 325 D 325
Score = 32.7 bits (73), Expect = 1.0
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)
Query: 379 GKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILT 432
G+ VYV T +L E G++ Y+ H DD DK + L + E LT
Sbjct: 184 GRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD----VDKLREQLSTSENALT 233
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 144 bits (364), Expect = 2e-34
Identities = 111/380 (29%), Positives = 189/380 (49%), Gaps = 46/380 (12%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYV 168
+E + RR K + EL+ +P + ++ LDK +++R+A+ LR+ K L++ V
Sbjct: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSS--V 73
Query: 169 GSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLF 228
S D ++ +L LK EGF+ VV + G ++F+S+++SK + Q LTG S+F
Sbjct: 74 CSENESEAEADQQMDNLYLKALEGFIAVV-TQDGDMIFLSENISKFMGLTQVELTGHSIF 132
Query: 229 DFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKS 288
DF HP D +++E LS + + G+ + R FF R+K
Sbjct: 133 DFTHPCDHEEIRENLS------------------LKNGSGFGKKSKDMSTERDFFMRMK- 173
Query: 289 CKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSW---PPN--IVGMEEERNSKKDNSNF 343
C ++ G N K + +HCTG ++ + PP+ + G +E S
Sbjct: 174 CTVT---NRGRTVNLKSATWK---VLHCTGQVKVYNNCPPHNSLCGYKEPLLS------- 220
Query: 344 TCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTS 403
CL+ + +P P + +I + F++R +++ KF Y D R T ++GY P+ELLG S
Sbjct: 221 -CLIIM--CEPIQHPSHM-DIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRS 276
Query: 404 CYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELE 463
YE++H D N+T H+ L +K ++++ Y+ AK G +V L++Q NP + +
Sbjct: 277 AYEFYHALDSENMTKSHQN-LCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQ 335
Query: 464 YIVSVNTLVLGHSEPGEASF 483
I+ VN VL E + F
Sbjct: 336 CIMCVN-YVLSEIEKNDVVF 354
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 144 bits (363), Expect = 2e-34
Identities = 113/391 (28%), Positives = 192/391 (49%), Gaps = 45/391 (11%)
Query: 94 SRVEDG--EHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLR 151
S + DG E K KA R + +++EK+RRD+ N LI+EL +M+P ARK+DK TVL+
Sbjct: 19 SSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQ 75
Query: 152 MAVQHLRSLKGLT----NSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFV 207
++ LR K +T S + +++P+FL + E L+L+ +GF + + G I++V
Sbjct: 76 KSIDFLRKHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTD-GSIIYV 134
Query: 208 SKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDI---SPREKLIDAKTGLQVH 264
S+SV+ +L + + L QS+F+F+ + ++V + LS+ + S + + +K L+
Sbjct: 135 SESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFC 194
Query: 265 SNLHAGRTRVYSGSRR---SFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLR 321
++ G S F KS H + ++ HR Y
Sbjct: 195 CHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSY--------- 245
Query: 322 SWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKF 381
E+R C VA RL + + EF +R ++ KF
Sbjct: 246 ----------EDR---------VCFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKF 286
Query: 382 VYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKD 441
+++D RA I+GYLP E+LGTS Y+Y+H DD NL H+ ++Q K + Y+F K
Sbjct: 287 LFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQ-YGKGKSCYYRFLTKG 345
Query: 442 GSFVTLKSQWFSFTNPWTKELEYIVSVNTLV 472
++ L++ ++ + W E+IV +T+V
Sbjct: 346 QQWIWLQTHYYITYHQWNSRPEFIVCTHTVV 376
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 137 bits (344), Expect = 4e-32
Identities = 110/385 (28%), Positives = 193/385 (50%), Gaps = 46/385 (11%)
Query: 93 GSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRM 152
G+ + + ++ + +E + RR K + + EL+ +P + ++ LDK +V+R+
Sbjct: 3 GAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRL 62
Query: 153 AVQHLRSLKGLTNSYVGSNYRPSFLQDN---ELRHLILKTAEGFLFVVGCERGKILFVSK 209
+ +LR K L + ++D+ ++ LK +GF+ V+ + G ++++S
Sbjct: 63 TISYLRVRKLLDAGDLD-------IEDDMKAQMNCFYLKALDGFVMVL-TDDGDMIYISD 114
Query: 210 SVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHA 269
+V+K + Q LTG S+FDF HP D +++E L+ R L+ K G +
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTH-----RNGLV--KKGKE------- 160
Query: 270 GRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVG 329
++RSFF R+K C ++ + G N K + +HCTG++ + N
Sbjct: 161 ------QNTQRSFFLRMK-CTLTSR---GRTMNIKSATWK---VLHCTGHIHVYDTN--S 205
Query: 330 MEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRAT 389
+ + KK TCLV I +P P N EI + F++R +++ KF Y D+R T
Sbjct: 206 NQPQCGYKKPP--MTCLVLI--CEPIPHPSNI-EIPLDSKTFLSRHSLDMKFSYCDERIT 260
Query: 390 AILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKS 449
++GY P+ELLG S YEY+H D ++LT H + +K ++ T Y+ AK G +V +++
Sbjct: 261 ELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVET 319
Query: 450 QWFSFTNPWTKELEYIVSVNTLVLG 474
Q N + + IV VN +V G
Sbjct: 320 QATVIYNTKNSQPQCIVCVNYVVSG 344
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 137 bits (344), Expect = 4e-32
Identities = 110/385 (28%), Positives = 193/385 (50%), Gaps = 46/385 (11%)
Query: 93 GSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRM 152
G+ + + ++ + +E + RR K + + EL+ +P + ++ LDK +V+R+
Sbjct: 3 GAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRL 62
Query: 153 AVQHLRSLKGLTNSYVGSNYRPSFLQDN---ELRHLILKTAEGFLFVVGCERGKILFVSK 209
+ +LR K L + ++D+ ++ LK +GF+ V+ + G ++++S
Sbjct: 63 TISYLRVRKLLDAGDLD-------IEDDMKAQMNCFYLKALDGFVMVL-TDDGDMIYISD 114
Query: 210 SVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHA 269
+V+K + Q LTG S+FDF HP D +++E L+ R L+ K G +
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTH-----RNGLV--KKGKE------- 160
Query: 270 GRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVG 329
++RSFF R+K C ++ + G N K + +HCTG++ + N
Sbjct: 161 ------QNTQRSFFLRMK-CTLTSR---GRTMNIKSATWK---VLHCTGHIHVYDTN--S 205
Query: 330 MEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRAT 389
+ + KK TCLV I +P P N EI + F++R +++ KF Y D+R T
Sbjct: 206 NQPQCGYKKPP--MTCLVLI--CEPIPHPSNI-EIPLDSKTFLSRHSLDMKFSYCDERIT 260
Query: 390 AILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKS 449
++GY P+ELLG S YEY+H D ++LT H + +K ++ T Y+ AK G +V +++
Sbjct: 261 ELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVET 319
Query: 450 QWFSFTNPWTKELEYIVSVNTLVLG 474
Q N + + IV VN +V G
Sbjct: 320 QATVIYNTKNSQPQCIVCVNYVVSG 344
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 130 bits (326), Expect = 5e-30
Identities = 104/382 (27%), Positives = 190/382 (49%), Gaps = 49/382 (12%)
Query: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
K +A R + +++EK+RRD+ N LI+ELS+M+P RK+DK TVL + L+ +
Sbjct: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLPG---NTRKMDKTTVLEKVIGFLQKHNEV 62
Query: 164 TNSY----VGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ 219
+ + +++PSFL + E L+L+ +GF+ V + G I++VS S++ +L +
Sbjct: 63 SAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLP 121
Query: 220 ASLTGQSLFDFLHPKDVAKVKEQLSSFDI---SPREKLIDAKTGLQVHSNLHAGRTRVYS 276
+ + Q+L +FL ++ ++V + LSS + SP + + + + L+
Sbjct: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLE-------------- 167
Query: 277 GSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSW----PPNIVGMEE 332
F+C + ++ KE E+ KF G RS+ P+ G +
Sbjct: 168 -----FYCHLLRGSLNPKE-------FPTYEYIKF-----VGNFRSYNNVPSPSCNGFDN 210
Query: 333 --ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATA 390
R + C +A RL + ++ EF +R ++ KF+++D RA
Sbjct: 211 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 270
Query: 391 ILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQ 450
I+GYLP E+LGTS Y+Y+H DD L H+ ++Q K + Y+F K ++ L++
Sbjct: 271 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQWIWLQTH 329
Query: 451 WFSFTNPWTKELEYIVSVNTLV 472
++ + W + E+IV +++V
Sbjct: 330 YYITYHQWNSKPEFIVCTHSVV 351
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 121 bits (303), Expect = 2e-27
Identities = 110/402 (27%), Positives = 183/402 (45%), Gaps = 50/402 (12%)
Query: 100 EHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRS 159
+H+ + +E + RR + ++ +L+ +P ++ LDK +++R+ + +LR
Sbjct: 5 DHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 64
Query: 160 LK----GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKIL 215
+ G N VG+ P L LK EGF+ V+ E G + ++S++VSK L
Sbjct: 65 HRLCAAGEWNQ-VGAGGEP-------LDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
Query: 216 NYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVY 275
Q L G S+FDF+HP D +E+L DA T Q S R +V
Sbjct: 116 GLSQLELIGHSIFDFIHPCD---------------QEELQDALTPQQTLS-----RRKVE 155
Query: 276 SGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERN 335
+ + R F R+KS S G N K + ++C+G++R++ P
Sbjct: 156 APTERCFSLRMKSTLTS----RGRTLNLKAATWK---VLNCSGHMRAYKPP--AQTSPAG 206
Query: 336 SKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYL 395
S CLV I P+ S E + F++R +++ KF Y D R + GY
Sbjct: 207 SPDSEPPLQCLVLICEAIPH---PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYS 263
Query: 396 PQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFT 455
P +L+G S YEY H D ++ K L SK + +T Y+F A+ G ++ ++Q +
Sbjct: 264 PDDLIGCSAYEYIHALD-SDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVS 322
Query: 456 NPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQ 497
+ E IV V+ L+ E G + S + +E+ SR+
Sbjct: 323 GGRGPQSESIVCVHFLISQVEETG----VVLSLEQTEQHSRR 360
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 119 bits (299), Expect = 7e-27
Identities = 109/393 (27%), Positives = 179/393 (45%), Gaps = 50/393 (12%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLK----GLT 164
+E + RR + ++ +L+ +P ++ LDK +++R+ + +LR + G
Sbjct: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 75
Query: 165 NSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTG 224
N VG+ P L LK EGF+ V+ E G + ++S++VSK L Q L G
Sbjct: 76 NQ-VGAGGEP-------LDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIG 126
Query: 225 QSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFC 284
S+FDF+HP D +E+L DA T Q S R +V + + R F
Sbjct: 127 HSIFDFIHPCD---------------QEELQDALTPQQTLS-----RRKVEAPTERCFSL 166
Query: 285 RIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFT 344
R+KS S G N K + ++C+G++R++ P S
Sbjct: 167 RMKSTLTS----RGRTLNLKAATWK---VLNCSGHMRAYKPP--AQTSPAGSPDSEPPLQ 217
Query: 345 CLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSC 404
CLV I P+ S E + F++R +++ KF Y D R + GY P +L+G S
Sbjct: 218 CLVLICEAIPH---PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSA 274
Query: 405 YEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEY 464
YEY H D ++ K L SK + +T Y+F A+ G ++ ++Q + + E
Sbjct: 275 YEYIHALD-SDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSES 333
Query: 465 IVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQ 497
IV V+ L+ E G + S + +E+ SR+
Sbjct: 334 IVCVHFLISQVEETG----VVLSLEQTEQHSRR 362
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 119 bits (298), Expect = 8e-27
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 57/373 (15%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL----KGLT 164
+E + RR+K N+ EL+ ++P + + +LDK +++R+ +L+ +GL
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 165 NSYVGSNYRPSFLQD--NELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
++ G + R S L + EL +L+T +GF+FVV + GKI+++S++ S L Q L
Sbjct: 62 EAW-GHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVEL 119
Query: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
TG S+++++HP D ++ L++ H H+ + Y RSF
Sbjct: 120 TGNSIYEYIHPADHDEMTAVLTA------------------HQPYHSHFVQEYE-IERSF 160
Query: 283 FCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSN 342
F R+K + K G K IHC+GYL+ R D S
Sbjct: 161 FLRMKC--VLAKRNAGLTCGGYK-------VIHCSGYLKI-----------RQYSLDMSP 200
Query: 343 FT-C-----LVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
F C LVA+G P P EI + F+ R +++ K +++D R + GY P
Sbjct: 201 FDGCYQNVGLVAVGHSLP---PSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEP 257
Query: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Q+L+ + Y + H D +L H +L K ++ T Y+F AK G +V ++S N
Sbjct: 258 QDLIEKTLYHHVHGCDTFHLRCAHHLLL-VKGQVTTKYYRFLAKHGGWVWVQSYATIVHN 316
Query: 457 PWTKELEYIVSVN 469
+ IVSVN
Sbjct: 317 SRSSRPHCIVSVN 329
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 115 bits (289), Expect = 9e-26
Identities = 104/373 (27%), Positives = 174/373 (46%), Gaps = 57/373 (15%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL----KGLT 164
+E K RR+K N EL+ ++P + + +LDK +++R+ +L+ +GL
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 165 NSYVGSNYRPSFLQD--NELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
+++ G R L EL +L+T +GF+FVV + GKI+++S++ S L Q L
Sbjct: 62 DAW-GQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
Query: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
TG S+++++HP D ++ L++ H LH + Y RSF
Sbjct: 120 TGNSIYEYIHPSDHDEMTAVLTA------------------HQPLHHHLLQEYE-IERSF 160
Query: 283 FCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSN 342
F R+K + K G + K IHC+GYL+ R D S
Sbjct: 161 FLRMKC--VLAKRNAGLTCSGYK-------VIHCSGYLKI-----------RQYMLDMSL 200
Query: 343 F-TC-----LVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
+ +C LVA+G+ P P EI + F+ R +++ K +++D R T + GY P
Sbjct: 201 YDSCYQIVGLVAVGQSLP---PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEP 257
Query: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Q+L+ + Y + H D +L H +L K ++ T Y+ +K G +V ++S N
Sbjct: 258 QDLIEKTLYHHVHGCDVFHLRYAHHLLL-VKGQVTTKYYRLLSKRGGWVWVQSYATVVHN 316
Query: 457 PWTKELEYIVSVN 469
+ IVSVN
Sbjct: 317 SRSSRPHCIVSVN 329
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 115 bits (289), Expect = 9e-26
Identities = 104/373 (27%), Positives = 174/373 (46%), Gaps = 57/373 (15%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL----KGLT 164
+E K RR+K N EL+ ++P + + +LDK +++R+ +L+ +GL
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 165 NSYVGSNYRPSFLQD--NELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
+++ G R L EL +L+T +GF+FVV + GKI+++S++ S L Q L
Sbjct: 62 DAW-GQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
Query: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
TG S+++++HP D ++ L++ H LH + Y RSF
Sbjct: 120 TGNSIYEYIHPSDHDEMTAVLTA------------------HQPLHHHLLQEYE-IERSF 160
Query: 283 FCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSN 342
F R+K + K G + K IHC+GYL+ R D S
Sbjct: 161 FLRMKC--VLAKRNAGLTCSGYK-------VIHCSGYLKI-----------RQYMLDMSL 200
Query: 343 F-TC-----LVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
+ +C LVA+G+ P P EI + F+ R +++ K +++D R T + GY P
Sbjct: 201 YDSCYQIVGLVAVGQSLP---PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEP 257
Query: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Q+L+ + Y + H D +L H +L K ++ T Y+ +K G +V ++S N
Sbjct: 258 QDLIEKTLYHHVHGCDVFHLRYAHHLLL-VKGQVTTKYYRLLSKRGGWVWVQSYATVVHN 316
Query: 457 PWTKELEYIVSVN 469
+ IVSVN
Sbjct: 317 SRSSRPHCIVSVN 329
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 109 bits (273), Expect = 7e-24
Identities = 118/504 (23%), Positives = 208/504 (41%), Gaps = 70/504 (13%)
Query: 50 RKRKGSDSDPS--QSGIMTEKVVEKLSQNPLTYLLSTRIEISASSG------SRVEDGEH 101
R +GSD D S + G++ E + S + + +++ ++SG S+V+ +
Sbjct: 51 RDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKE 110
Query: 102 QVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLK 161
+K + H +K+ + K + L A+ R + ++ Q L S +
Sbjct: 111 LIKTLKELKVHLPADKKAKGKASTLATLKYAL--------RSVKQVKANEEYYQLLMSSE 162
Query: 162 GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQAS 221
G +Y ++ H++ K A+ F V GKIL++S V+ I + + +
Sbjct: 163 GHPCGADVPSYTVEEMESVTSEHIV-KNADMFAVAVSLVSGKILYISDQVASIFHCKRDA 221
Query: 222 LTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRS 281
+ +FL P DV S + + A + Q +S
Sbjct: 222 FSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECME------------EKS 269
Query: 282 FFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNS 341
FFCR+ SV++ H + +++ T YL + R+ + S
Sbjct: 270 FFCRV-----SVRKSH--------ENEIRYHPFRMTPYL----------VKVRDQQGAES 306
Query: 342 NFTCLVAIGRLQP-YIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELL 400
CL+ R+ Y P+ E + F T N F VD+RA +LGYLPQ+L+
Sbjct: 307 QLCCLLLAERVHSGYEAPRIPPEKRI----FTTTHTPNCLFQDVDERAVPLLGYLPQDLI 362
Query: 401 GTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDS-YKFRAKDGSFVTLKSQWFSFTNPWT 459
T H D + HK +LQS + S +FRA++G ++TL + W SF NPW+
Sbjct: 363 ETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWS 422
Query: 460 KELEYIVSVNTLVLG---------HSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTV 510
+++ +I+ + + +G H E + P + +E+ R VP +
Sbjct: 423 RKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSS-- 480
Query: 511 LGAGSIGTDIANEILDLQRLQSSS 534
G GS+G++ ++E L Q S S
Sbjct: 481 -GYGSLGSNGSHEHLMSQTSSSDS 503
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 107 bits (267), Expect = 3e-23
Identities = 115/447 (25%), Positives = 195/447 (43%), Gaps = 71/447 (15%)
Query: 97 EDGEHQVKMKAFREAHSQTEKR-RRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQ 155
+D + +++A R+ S+ R RR K N EL+ ++P + +LDK +++R+ +
Sbjct: 10 QDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
Query: 156 HLRSLKGLTN-----------------SYVGSNYR--PSFLQ----DNELRHLILKTAEG 192
+L+ ++ N S G+ R PS L + L IL++ +G
Sbjct: 70 YLK-MRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128
Query: 193 FLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPRE 252
F+F + E GK L++S++VS L Q LTG S+FD++HP D ++ EQL + P
Sbjct: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL-GMKLPPGR 186
Query: 253 KLID---AKTGLQVHSNLHAGRT--RVYSGS----------RRSFFCRIKSCKISVKEEH 297
L+ A+ G S+ T V S S RSFF R+KS
Sbjct: 187 GLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTL------- 239
Query: 298 GCLPNSKKKEHRK---FYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQP 354
+K+ H K + IH TG LR V + R S LV + P
Sbjct: 240 -----TKRGVHIKSSGYKVIHITGRLRL----RVSLSHGRTVP---SQIMGLVVVAHALP 287
Query: 355 YIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHN 414
P E+ + F+TR ++ +Y + R + + P +++G CY + H +D
Sbjct: 288 ---PPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVE 344
Query: 415 NLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLG 474
+ H +L +K + +T Y++ K+G ++ ++S N + I+ VN L+
Sbjct: 345 GIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSN 403
Query: 475 ---HSEPGEASFLPCSSQSSEESSRQS 498
P + + LP + + ESS S
Sbjct: 404 PEYKDTPMDIAQLPHLPEKTSESSETS 430
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 105 bits (263), Expect = 1e-22
Identities = 92/311 (29%), Positives = 144/311 (46%), Gaps = 38/311 (12%)
Query: 187 LKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSF 246
LK EGF+ V+ E G + ++S++VSK L Q L G S+FDF+HP D
Sbjct: 34 LKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCD----------- 81
Query: 247 DISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKK 306
+E+L DA T Q S R +V + + R F R+KS S G N K
Sbjct: 82 ----QEELQDALTPQQTLS-----RRKVEAPTERCFSLRMKSTLTS----RGRTLNLKAA 128
Query: 307 EHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINV 366
+ ++C+G++R++ P S CLV I P+ S E +
Sbjct: 129 TWK---VLNCSGHMRAYKPP--AQTSPAGSPDSEPPLQCLVLICEAIPH---PGSLEPPL 180
Query: 367 KPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQS 426
F++R +++ KF Y D R + GY P +L+G S YEY H D ++ K L S
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALD-SDAVSKSIHTLLS 239
Query: 427 KEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPC 486
K + +T Y+F A+ G ++ ++Q + + E IV V+ L+ E G +
Sbjct: 240 KGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETG----VVL 295
Query: 487 SSQSSEESSRQ 497
S + +E+ SR+
Sbjct: 296 SLEQTEQHSRR 306
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 105 bits (262), Expect = 1e-22
Identities = 109/421 (25%), Positives = 181/421 (42%), Gaps = 70/421 (16%)
Query: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLK------- 161
+E + RR K N EL+ ++P ++ +LDK +++R++V +LR +
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
Query: 162 -----------GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKS 210
GL G S + + L IL++ +GF+F + E GK L++S++
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
Query: 211 VSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPR-------EKLIDAKTGLQV 263
VS L Q +TG S+FD++HP D ++V EQL +P + + L
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 264 HSNLHAGRTRVYSGS---RRSFFCRIKSCKISVKEEHGCLPNSKKKEHRK---FYTIHCT 317
+ A T+V S RSFF R+KS +K+ H K + IH T
Sbjct: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTL------------TKRGLHVKASGYKVIHVT 273
Query: 318 GYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAV 377
G LR+ + +G LVA+G P P E+ + + R ++
Sbjct: 274 GRLRA---HALG----------------LVALGHTLP---PAPLAELPLHGHMIVFRLSL 311
Query: 378 NGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKF 437
+ + R + + P EL+G SCY++ H D + H +L K +++T Y++
Sbjct: 312 GLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLL-DKGQVMTGYYRW 370
Query: 438 RAKDGSFVTLKSQWF---SFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEES 494
+ G FV L+S S +P + ++ V + G P +A LP S E S
Sbjct: 371 LQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEAS 430
Query: 495 S 495
S
Sbjct: 431 S 431
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 103 bits (257), Expect = 5e-22
Identities = 116/465 (24%), Positives = 197/465 (42%), Gaps = 88/465 (18%)
Query: 97 EDGEHQVKMKAFREAHSQTEKR-RRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQ 155
+D + +++A R+ S+ R RR K N EL+ ++P + +LDK +++R+ +
Sbjct: 10 QDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
Query: 156 HLR-----------------------SLKGLTN------------SYVGSNYR--PSFLQ 178
+L+ S+KG+ +G+ R PS L
Sbjct: 70 YLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALA 129
Query: 179 ----DNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPK 234
+ L IL++ +GF+F + E GK L++S++VS L Q LTG S+FD++HP
Sbjct: 130 IEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPG 188
Query: 235 DVAKVKEQLSSFDISPREKLID---AKTGLQVHSNLHAGRT--RVYSGS----------R 279
D ++ EQL + P L+ A+ G S+ T V S S
Sbjct: 189 DHVEMAEQL-GMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLE 247
Query: 280 RSFFCRIKSCKISVKEEHGCLPNSKKKEHRK---FYTIHCTGYLRSWPPNIVGMEEERNS 336
RSFF R+KS +K+ H K + IH TG LR V + R
Sbjct: 248 RSFFIRMKSTL------------TKRGVHIKSSGYKVIHITGRLRL----RVSLSHGRTV 291
Query: 337 KKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
S LV + P P E+ + F+TR ++ +Y + R + + P
Sbjct: 292 P---SQIMGLVVVAHALP---PPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTP 345
Query: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
+++G CY + H +D + H +L +K + +T Y++ K+G ++ ++S N
Sbjct: 346 VDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQSSATIAIN 404
Query: 457 PWTKELEYIVSVNTLVLG---HSEPGEASFLPCSSQSSEESSRQS 498
+ I+ VN L+ P + + LP + + ESS S
Sbjct: 405 AKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETS 449
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 85.1 bits (209), Expect = 2e-16
Identities = 86/382 (22%), Positives = 156/382 (40%), Gaps = 55/382 (14%)
Query: 100 EHQVKMKAFREAHSQTEKRRR--DKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHL 157
E ++ K +HS+ + R R +++ +++E+ P + K L L A++ +
Sbjct: 30 EFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFP--SERRNKPSTLDALNYALRCV 87
Query: 158 RSLKGLTNSY--VGSNYRP----SFLQDNELRHLIL----KTAEGFLFVVGCERGKILFV 207
S++ + + + N P S EL + K + F+ V G+++ +
Sbjct: 88 HSVQANSEFFQILSQNGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHI 147
Query: 208 SKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNL 267
S+ + ILN + L D L P+D+ A+ L +N
Sbjct: 148 SEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAHT-------------ARAQLPFWNNW 194
Query: 268 HAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNI 327
R + FFCRI+ G ++K H F I P +
Sbjct: 195 TQRAARYECAPVKPFFCRIR----------GGEDRKQEKCHSPFRII----------PYL 234
Query: 328 VGMEEERNSKKDNSNFTCLVAIGRLQP-YIVPQNSGEINVKPTEFITRFAVNGKFVYVDQ 386
+ + + + S CL + ++ Y P+ I V F T F+ VD+
Sbjct: 235 IHVHHPAQPELE-SEPCCLTVVEKIHSGYEAPR----IPVNKRIFTTTHTPGCVFLEVDE 289
Query: 387 RATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQ--SKEKILTDSYKFRAKDGSF 444
+A +LGYLPQ+L+GTS Y H +D + + H+ VL+ +F ++G +
Sbjct: 290 KAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDY 349
Query: 445 VTLKSQWFSFTNPWTKELEYIV 466
+ L S W SF NPW++++ +I+
Sbjct: 350 IILDSSWSSFVNPWSRKISFII 371
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 83.6 bits (205), Expect = 5e-16
Identities = 96/416 (23%), Positives = 169/416 (40%), Gaps = 61/416 (14%)
Query: 115 TEKRRRDKMNNLIEELSAMI----PQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVG- 169
TEKR R++ N IEEL+ +I + K DK +L+ V+ +R +K +
Sbjct: 34 TEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAAN 93
Query: 170 ---------SNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQA 220
S+ + + L ++L+ +GF FVV E G ++FVS++V++ L Y+Q
Sbjct: 94 IDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFVSENVTQYLRYNQE 152
Query: 221 SLTGQSLFDFLHPKDVAK-VKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSR 279
L +S++ LH D + VK L ++ + +G N H
Sbjct: 153 ELMNKSVYSILHVGDHTEFVKNLLPKSIVNG-----GSWSGEPPRRNSH----------- 196
Query: 280 RSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKD 339
+F CR+ + EE G + ++ H+K+ T+ C + S P +I E+ S
Sbjct: 197 -TFNCRMLVKPLPDSEEEG---HDNQEAHQKYETMQC--FAVSQPKSIKEEGEDLQS--- 247
Query: 340 NSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL 399
CL+ + R VP + F TR + GK +D E
Sbjct: 248 -----CLICVARR----VPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWED 298
Query: 400 LGTSCYEYF---HQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
L C + F H+ + + +H + + + Y+F DG+ V +++ +
Sbjct: 299 LVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRS 358
Query: 457 PWTKELEYIVSV-------NTLVLGHSEPGEASFLPCSSQSSEESSRQS-CMSVPG 504
T E + ++S+ N V+ G+ P + SS + Q+ C PG
Sbjct: 359 QTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPG 414
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 81.3 bits (199), Expect = 3e-15
Identities = 89/375 (23%), Positives = 162/375 (43%), Gaps = 58/375 (15%)
Query: 116 EKRRRDKMNNLIEEL----SAMIPQCNPMARKLDKLTVLRMAVQHLRSLK--GLTNSYVG 169
EKRRR++ + IEEL SA + + K DK +L+ V+ +R +K G T S
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 170 -------SNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
S+ + + L L+L+ +GFLFVV + G I+FVS++V++ L Y Q L
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
S+++ LH +D + L ++ G+ + ++ +
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVN----------GVSWTNETQRQKSHTF------- 195
Query: 283 FCRIKSCKISVKEEHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDN 340
+C++ +K H L N+ + +++ T+ C + S P ++ E+ S
Sbjct: 196 -----NCRMLMKTPHDILEDINASPEMRQRYETMQC--FALSQPRAMMEEGEDLQS---- 244
Query: 341 SNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQ---RATAILGYLPQ 397
C++ + R + P FITR ++GK V +D R++ G+ +
Sbjct: 245 ----CMICVARR----ITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGF--E 294
Query: 398 ELLGTSCYEYFHQDDHNNLTDK-HKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
+++ +F +D + + K H T Y+F DG+ VT +++ F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354
Query: 457 PWTKELEYIVSVNTL 471
P T + VS + L
Sbjct: 355 PVTNDRHGFVSTHFL 369
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 81.3 bits (199), Expect = 3e-15
Identities = 89/375 (23%), Positives = 162/375 (43%), Gaps = 58/375 (15%)
Query: 116 EKRRRDKMNNLIEEL----SAMIPQCNPMARKLDKLTVLRMAVQHLRSLK--GLTNSYVG 169
EKRRR++ + IEEL SA + + K DK +L+ V+ +R +K G T S
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 170 -------SNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
S+ + + L L+L+ +GFLFVV + G I+FVS++V++ L Y Q L
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDL 152
Query: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
S+++ LH +D + L ++ G+ + ++ +
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVN----------GVSWTNETQRQKSHTF------- 195
Query: 283 FCRIKSCKISVKEEHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDN 340
+C++ +K H L N+ + +++ T+ C + S P ++ E+ S
Sbjct: 196 -----NCRMLMKTPHDILEDINASPEMRQRYETMQC--FALSQPRAMMEEGEDLQS---- 244
Query: 341 SNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQ---RATAILGYLPQ 397
C++ + R + P FITR ++GK V +D R++ G+ +
Sbjct: 245 ----CMICVARR----ITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGF--E 294
Query: 398 ELLGTSCYEYFHQDDHNNLTDK-HKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
+++ +F +D + + K H T Y+F DG+ VT +++ F N
Sbjct: 295 DIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRN 354
Query: 457 PWTKELEYIVSVNTL 471
P T + VS + L
Sbjct: 355 PVTNDRHGFVSTHFL 369
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 73.9 bits (180), Expect = 4e-13
Identities = 84/370 (22%), Positives = 160/370 (43%), Gaps = 51/370 (13%)
Query: 83 STRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMAR 142
S+ I+ +S R + + VK S KR RD++N ++ L++++P +
Sbjct: 3 SSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVIN 62
Query: 143 KLDKLTVLRMAVQHLRS--------------LKGLTNSYVGSNYRPSF-LQDNELRHLIL 187
KLDKL+VLR++V +LR+ G ++ +N+R LQ+ E +L
Sbjct: 63 KLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGE---FLL 119
Query: 188 KTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFD 247
+ GF+ VV + + + S ++ L + Q+ + QS+++ +H +D A+ + QL +
Sbjct: 120 QALNGFVLVVTTD-ALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL-HWA 177
Query: 248 ISPRE-----KLIDAKTGLQ---VHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGC 299
++P + + I+ TGL V N R F CR++ C
Sbjct: 178 LNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLR-----------C 226
Query: 300 LPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQ 359
L ++ F ++ G L+ + ++ KD S +A+ + + P
Sbjct: 227 LLDNSS----GFLAMNFQGKLKY-------LHGQKKKGKDGSILPPQLALFAIATPLQPP 275
Query: 360 NSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGT-SCYEYFHQDDHNNLTD 418
+ EI K F T+ ++ + D + +LGY EL S Y++ H D +
Sbjct: 276 SILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAE 335
Query: 419 KHKAVLQSKE 428
H ++++ E
Sbjct: 336 SHIRMIKTGE 345
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/373 (24%), Positives = 158/373 (42%), Gaps = 57/373 (15%)
Query: 91 SSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEEL----SAMIPQCNPMARKLDK 146
SS H+ K S TEKRRR++ N +EEL SA I + ++ K DK
Sbjct: 7 SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDK 66
Query: 147 LTVLRMAVQHLRSLKGL------TNSYVG----SNYRPSFLQDNELRHLILKTAEGFLFV 196
+L+ V ++ +K + T+ V S+ ++ L L+L+ +GF FV
Sbjct: 67 CKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFV 126
Query: 197 VGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLID 256
V CE G+I+FVS++V+ L Y+Q L S++ LH D A+ + L + L++
Sbjct: 127 VNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLP------KSLVN 179
Query: 257 AKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHC 316
Q + ++ +F CR+ I +E G ++ +++ + C
Sbjct: 180 GVPWPQEATRRNS----------HTFNCRM---LIHPPDEPG---TENQEACQRYEVMQC 223
Query: 317 TGYLRSWPPNIVGMEEERNSKKDNSNF-TCLVAIGRLQPYIVPQNSGEINVKPTEFITRF 375
+ S P +I ++D +F +CL+ I R P P +G F+T+
Sbjct: 224 --FTVSQPKSI---------QEDGEDFQSCLICIARRLPR-PPAITG-----VESFMTKQ 266
Query: 376 AVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAV--LQSKEKILTD 433
GK + +D + G E L C F Q + + + ++ +
Sbjct: 267 DTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP 326
Query: 434 SYKFRAKDGSFVT 446
SY+F DG+ ++
Sbjct: 327 SYRFILNDGTMLS 339
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/373 (24%), Positives = 158/373 (42%), Gaps = 57/373 (15%)
Query: 91 SSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEEL----SAMIPQCNPMARKLDK 146
SS H+ K S TEKRRR++ N +EEL SA I + ++ K DK
Sbjct: 7 SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDK 66
Query: 147 LTVLRMAVQHLRSLKGL------TNSYVG----SNYRPSFLQDNELRHLILKTAEGFLFV 196
+L+ V ++ +K + T+ V S+ ++ L L+L+ +GF FV
Sbjct: 67 CKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFV 126
Query: 197 VGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLID 256
V CE G+I+FVS++V+ L Y+Q L S++ LH D A+ + L + L++
Sbjct: 127 VNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLP------KSLVN 179
Query: 257 AKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHC 316
Q + ++ +F CR+ I +E G ++ +++ + C
Sbjct: 180 GVPWPQEATRRNS----------HTFNCRM---LIHPPDEPG---TENQEACQRYEVMQC 223
Query: 317 TGYLRSWPPNIVGMEEERNSKKDNSNF-TCLVAIGRLQPYIVPQNSGEINVKPTEFITRF 375
+ S P +I ++D +F +CL+ I R P P +G F+T+
Sbjct: 224 --FTVSQPKSI---------QEDGEDFQSCLICIARRLPR-PPAITG-----VESFMTKQ 266
Query: 376 AVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAV--LQSKEKILTD 433
GK + +D + G E L C F Q + + + ++ +
Sbjct: 267 DTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP 326
Query: 434 SYKFRAKDGSFVT 446
SY+F DG+ ++
Sbjct: 327 SYRFILNDGTMLS 339
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,057,679
Number of Sequences: 37866
Number of extensions: 1056457
Number of successful extensions: 3322
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 3086
Number of HSP's gapped (non-prelim): 160
length of query: 636
length of database: 18,247,518
effective HSP length: 109
effective length of query: 527
effective length of database: 14,120,124
effective search space: 7441305348
effective search space used: 7441305348
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.