Search of human proteins with 31077211

Search of human proteins with 31077211

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
         (735 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...  1475   0.0  
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...  1473   0.0  
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]           609   e-174
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...   403   e-112
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...   402   e-112
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ...   339   5e-93
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]        275   1e-73
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]     275   1e-73
gi|21614542 single-minded homolog 1 [Homo sapiens]                    269   6e-72
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]    247   2e-65
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]    240   4e-63
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]              212   9e-55
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...   137   4e-32
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...   137   4e-32
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...   137   4e-32
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...   137   5e-32
gi|4758010 clock [Homo sapiens]                                       129   1e-29
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...   129   1e-29
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]              128   2e-29
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...   127   5e-29
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...   123   5e-28
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                   121   2e-27
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]              90   7e-18
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]               75   2e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]    74   4e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]    74   4e-13
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]    74   4e-13
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...    74   6e-13
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]    69   2e-11
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]    69   2e-11

>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score = 1475 bits (3818), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
           MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
Sbjct: 1   MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60

Query: 61  RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
           RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
Sbjct: 61  RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120

Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
           GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
Sbjct: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180

Query: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
           TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
Sbjct: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240

Query: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
           TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
Sbjct: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300

Query: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
           TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
Sbjct: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360

Query: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
           LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
Sbjct: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420

Query: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
           DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
Sbjct: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480

Query: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
           NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
Sbjct: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540

Query: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
           AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
Sbjct: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600

Query: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
           VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
Sbjct: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660

Query: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
           DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
Sbjct: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720

Query: 721 KMEHDGSLFQAVGII 735
           KMEHDGSLFQAVGII
Sbjct: 721 KMEHDGSLFQAVGII 735


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score = 1473 bits (3814), Expect = 0.0
 Identities = 734/734 (100%), Positives = 734/734 (100%)

Query: 1   MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60
           MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
Sbjct: 1   MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 60

Query: 61  RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
           RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
Sbjct: 61  RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120

Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180
           GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
Sbjct: 121 GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR 180

Query: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240
           TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
Sbjct: 181 TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK 240

Query: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300
           TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
Sbjct: 241 TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 300

Query: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360
           TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
Sbjct: 301 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV 360

Query: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420
           LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
Sbjct: 361 LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET 420

Query: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480
           DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
Sbjct: 421 DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP 480

Query: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540
           NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
Sbjct: 481 NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF 540

Query: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600
           AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
Sbjct: 541 AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT 600

Query: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660
           VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
Sbjct: 601 VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR 660

Query: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720
           DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
Sbjct: 661 DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR 720

Query: 721 KMEHDGSLFQAVGI 734
           KMEHDGSLFQAVGI
Sbjct: 721 KMEHDGSLFQAVGI 734


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score =  609 bits (1571), Expect = e-174
 Identities = 333/617 (53%), Positives = 429/617 (69%), Gaps = 60/617 (9%)

Query: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
           +KK+ SSERRKEKSRDAAR RRSKE+EVFYELAH+LPLPH+VSSHLDKAS+MRL IS+LR
Sbjct: 6   EKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLR 65

Query: 69  VRKLLDAGDLDIEDDMKA--QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
             KLL +   + E + +A  QM+  YLKAL+GF+ V+T DGDMI++S+N++K+MGLTQ E
Sbjct: 66  THKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVE 125

Query: 127 LTGHSVFDFTHPCDHEEMREMLTHRNG--LVKKGKEQNTQRSFFLRMKCTLTSRGRTMNI 184
           LTGHS+FDFTHPCDHEE+RE L+ +NG    KK K+ +T+R FF+RMKCT+T+RGRT+N+
Sbjct: 126 LTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNL 185

Query: 185 KSATWKVLHCTGHIHVYDT-NSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFL 243
           KSATWKVLHCTG + VY+    +   CGYK+P ++CL+++CEPI HPS+++IPLDSKTFL
Sbjct: 186 KSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245

Query: 244 SRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTG 303
           SRHS+DMKF+YCD+RITEL+GY PEELLGRS YE+YHALDS+++TK+H ++ TKGQV +G
Sbjct: 246 SRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSG 305

Query: 304 QYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
           QYRMLAK GGYVW+ETQ TVIYN +N QPQCI+CVNYV+S I ++D++FS+ QTE + KP
Sbjct: 306 QYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP 365

Query: 364 VESSDMKMTQLFTK----VESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE 419
                M M  +F        SE ++ LF KLK+EP+ L  LAP  GD IISLDFG     
Sbjct: 366 ---HLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFG----- 417

Query: 420 TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLE 479
             +Q  EE   Y   +LP                P+      LRS +     Q  A  L 
Sbjct: 418 --NQNFEESSAYGKAILP----------------PSQPWATELRSHS----TQSEAGSLP 455

Query: 480 PNPESLELSFTMPQ-IQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEK 538
                   +FT+PQ     + +PS  S+  S   PNSP +Y   +D+D+    K+E++EK
Sbjct: 456 --------AFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDL----KIEVIEK 503

Query: 539 LFAEDTEAKNPFSTQD--TDLDLEMLAPYIPMD-DDFQLRSFDQLSPLESSSASPESASP 595
           LFA DTEAK+  STQ    +LDLE LAPYIPMD +DFQL     + P E   A    ++P
Sbjct: 504 LFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQL---SPICPEERLLAENPQSTP 560

Query: 596 QSTVTVFQQTQIQEPTA 612
           Q   +    T I +P A
Sbjct: 561 QHCFSA--MTNIFQPLA 575


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score =  403 bits (1035), Expect = e-112
 Identities = 193/351 (54%), Positives = 261/351 (74%), Gaps = 2/351 (0%)

Query: 10  KKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV 69
           + + ++E RKEKSRDAARSRRS+E+EV Y+LAH LP    VS+HLDKAS+MRLTISYLR+
Sbjct: 7   RARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 66

Query: 70  RKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
            +L  AG+ +        ++  YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL G
Sbjct: 67  HRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126

Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATW 189
           HS+FDF HPCD EE+++ LT +  L ++  E  T+R F LRMK TLTSRGRT+N+K+ATW
Sbjct: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 186

Query: 190 KVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHS 247
           KVL+C+GH+  Y   +     G    +PP+ CLVLICE IPHP ++E PL    FLSRHS
Sbjct: 187 KVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHS 246

Query: 248 LDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRM 307
           LDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ  TGQYR 
Sbjct: 247 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRF 306

Query: 308 LAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
           LA+ GGY+W +TQATV+   +  Q + IVCV++++S + +  ++ SL+QTE
Sbjct: 307 LARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)

Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
           +P  + +TP P + +   P    E AL  +P    S +L   +  I D     +  ST  
Sbjct: 376 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 435

Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
           ++  P SP      + +D+ +E  +  E V +LF   +DTEA        QD D LDLEM
Sbjct: 436 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 489

Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
           LAPYI MDDDFQL                      RSF  LSP  LE S      + P+ 
Sbjct: 490 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 549

Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
           + +        +P+A++    A    L   ++D  E +++L       SPSP H
Sbjct: 550 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 600


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score =  402 bits (1034), Expect = e-112
 Identities = 193/347 (55%), Positives = 259/347 (74%), Gaps = 2/347 (0%)

Query: 14  SSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLL 73
           ++E RKEKSRDAARSRRS+E+EV Y+LAH LP    VS+HLDKAS+MRLTISYLR+ +L 
Sbjct: 9   TTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC 68

Query: 74  DAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVF 133
            AG+ +        ++  YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL GHS+F
Sbjct: 69  AAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIF 128

Query: 134 DFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLH 193
           DF HPCD EE+++ LT +  L ++  E  T+R F LRMK TLTSRGRT+N+K+ATWKVL+
Sbjct: 129 DFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLN 188

Query: 194 CTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMK 251
           C+GH+  Y   +     G    +PP+ CLVLICE IPHP ++E PL    FLSRHSLDMK
Sbjct: 189 CSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMK 248

Query: 252 FSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKR 311
           F+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ  TGQYR LA+ 
Sbjct: 249 FTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARS 308

Query: 312 GGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
           GGY+W +TQATV+   +  Q + IVCV++++S + +  ++ SL+QTE
Sbjct: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)

Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
           +P  + +TP P + +   P    E AL  +P    S +L   +  I D     +  ST  
Sbjct: 374 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 433

Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
           ++  P SP      + +D+ +E  +  E V +LF   +DTEA        QD D LDLEM
Sbjct: 434 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 487

Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
           LAPYI MDDDFQL                      RSF  LSP  LE S      + P+ 
Sbjct: 488 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 547

Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
           + +        +P+A++    A    L   ++D  E +++L       SPSP H
Sbjct: 548 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 598


>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
           [Homo sapiens]
          Length = 613

 Score =  339 bits (870), Expect = 5e-93
 Identities = 161/301 (53%), Positives = 220/301 (73%), Gaps = 2/301 (0%)

Query: 60  MRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY 119
           MRLTISYLR+ +L  AG+ +        ++  YLKAL+GFVMVLT +GDM Y+S+NV+K+
Sbjct: 1   MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60

Query: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG 179
           +GL+Q EL GHS+FDF HPCD EE+++ LT +  L ++  E  T+R F LRMK TLTSRG
Sbjct: 61  LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120

Query: 180 RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPL 237
           RT+N+K+ATWKVL+C+GH+  Y   +     G    +PP+ CLVLICE IPHP ++E PL
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180

Query: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
               FLSRHSLDMKF+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +K
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240

Query: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
           GQ  TGQYR LA+ GGY+W +TQATV+   +  Q + IVCV++++S + +  ++ SL+QT
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300

Query: 358 E 358
           E
Sbjct: 301 E 301



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)

Query: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
           +P  + +TP P + +   P    E AL  +P    S +L   +  I D     +  ST  
Sbjct: 320 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 379

Query: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
           ++  P SP      + +D+ +E  +  E V +LF   +DTEA        QD D LDLEM
Sbjct: 380 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 433

Query: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
           LAPYI MDDDFQL                      RSF  LSP  LE S      + P+ 
Sbjct: 434 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 493

Query: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
           + +        +P+A++    A    L   ++D  E +++L       SPSP H
Sbjct: 494 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 544


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score =  275 bits (703), Expect = 1e-73
 Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
           KEKS++AA++RR KE+  FYELA  LPLP  ++S LDKAS++RLT SYL++R +   G  
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 79  DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
           D           D +  ++    L+ LDGFV V+  DG ++YIS+  + ++GL+Q ELTG
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121

Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
           +S++++ HP DH+EM  +LT    L     +E   +RSFFLRMKC L  R   +      
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179

Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
           +KV+HC+G++ +  Y  + +     Y+   +  LV + + +P  +  EI L S  F+ R 
Sbjct: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236

Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
           SLD+K  + D R+TE+ GYEP++L+ +++Y + H  D  HL   HH +  KGQVTT  YR
Sbjct: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296

Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
           +L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I   +L  SL+Q    +   +S
Sbjct: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352

Query: 367 SDMKMTQLFTKVES 380
            D   T L T  E+
Sbjct: 353 QDSWRTALSTSQET 366


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score =  275 bits (703), Expect = 1e-73
 Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
           KEKS++AA++RR KE+  FYELA  LPLP  ++S LDKAS++RLT SYL++R +   G  
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 79  DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
           D           D +  ++    L+ LDGFV V+  DG ++YIS+  + ++GL+Q ELTG
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121

Query: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
           +S++++ HP DH+EM  +LT    L     +E   +RSFFLRMKC L  R   +      
Sbjct: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179

Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
           +KV+HC+G++ +  Y  + +     Y+   +  LV + + +P  +  EI L S  F+ R 
Sbjct: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236

Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
           SLD+K  + D R+TE+ GYEP++L+ +++Y + H  D  HL   HH +  KGQVTT  YR
Sbjct: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296

Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
           +L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I   +L  SL+Q    +   +S
Sbjct: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352

Query: 367 SDMKMTQLFTKVES 380
            D   T L T  E+
Sbjct: 353 QDSWRTALSTSQET 366


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score =  269 bits (688), Expect = 6e-72
 Identities = 149/370 (40%), Positives = 221/370 (59%), Gaps = 18/370 (4%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG-- 76
           KEKS++AAR+RR KE+  FYELA  LPLP  ++S LDKAS++RLT SYL++R +   G  
Sbjct: 2   KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61

Query: 77  -------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
                       D++  ++    L+ LDGF+ V+  DG ++YIS+  + ++GL+Q ELTG
Sbjct: 62  EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121

Query: 130 HSVFDFTHPCDHEEMREMLT-HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
           +S++++ HP DH+EM  +LT H+       +E   +RSFFLRMKC L  R     +    
Sbjct: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179

Query: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
           +KV+HC+G++ +  Y  + +     Y+      LV +   +P  +  EI L S  F+ R 
Sbjct: 180 YKVIHCSGYLKIRQYSLDMSPFDGCYQN---VGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236

Query: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
           SLDMK  + D R+ EL GYEP++L+ +++Y + H  D+ HL   HH +  KGQVTT  YR
Sbjct: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296

Query: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
            LAK GG+VWV++ AT+++N+++S+P CIV VNYV++      L  SL Q     KP  S
Sbjct: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIS-ASKPAFS 355

Query: 367 SDMKMTQLFT 376
                T   T
Sbjct: 356 YTSSSTPTMT 365


>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score =  247 bits (631), Expect = 2e-65
 Identities = 153/430 (35%), Positives = 234/430 (54%), Gaps = 70/430 (16%)

Query: 18  RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
           RKEKSRDAARSRR KE+  FYELA  LPLP  ++S LDKAS++RLTISYL++R   + GD
Sbjct: 22  RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81

Query: 78  ----LDIE----------------------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 111
               L +E                      +  +A +    L++LDGFV  L  +G  +Y
Sbjct: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141

Query: 112 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR----NGLVKKGKEQN----- 162
           IS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L  +     GL+ +G  ++     
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201

Query: 163 -------------------------TQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGH 197
                                     +RSFF+RMK TLT RG  ++IKS+ +KV+H TG 
Sbjct: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITGR 259

Query: 198 IHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCD 256
           + +  + S+    G   P     LV++   +P P+  E+ +D   F++R ++D+   YC+
Sbjct: 260 LRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCE 315

Query: 257 ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVW 316
            RI++ M   P +++G+  Y + HA D + +  +H D+  KGQ  T  YR + K GGY+W
Sbjct: 316 NRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIW 375

Query: 317 VETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFT 376
           +++ AT+  N KN+  + I+ VNY++S     D    + Q   +  P ++S+   T   +
Sbjct: 376 IQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL--PEKTSESSETS-DS 432

Query: 377 KVESEDTSSL 386
           + +S+DTS +
Sbjct: 433 ESDSKDTSGI 442


>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
          Length = 920

 Score =  240 bits (612), Expect = 4e-63
 Identities = 153/449 (34%), Positives = 234/449 (52%), Gaps = 89/449 (19%)

Query: 18  RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77
           RKEKSRDAARSRR KE+  FYELA  LPLP  ++S LDKAS++RLTISYL++R   + GD
Sbjct: 22  RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81

Query: 78  ----LDIE-----------------------------------------DDMKAQMNCFY 92
               L +E                                         +  +A +    
Sbjct: 82  PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141

Query: 93  LKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR- 151
           L++LDGFV  L  +G  +YIS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L  + 
Sbjct: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201

Query: 152 ---NGLVKKGKEQN------------------------------TQRSFFLRMKCTLTSR 178
               GL+ +G  ++                               +RSFF+RMK TLT R
Sbjct: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261

Query: 179 GRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPL 237
           G  ++IKS+ +KV+H TG + +  + S+    G   P     LV++   +P P+  E+ +
Sbjct: 262 G--VHIKSSGYKVIHITGRLRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRI 315

Query: 238 DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTK 297
           D   F++R ++D+   YC+ RI++ M   P +++G+  Y + HA D + +  +H D+  K
Sbjct: 316 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 375

Query: 298 GQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQT 357
           GQ  T  YR + K GGY+W+++ AT+  N KN+  + I+ VNY++S     D    + Q 
Sbjct: 376 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 435

Query: 358 ECVLKPVESSDMKMTQLFTKVESEDTSSL 386
             +  P ++S+   T   ++ +S+DTS +
Sbjct: 436 PHL--PEKTSESSETS-DSESDSKDTSGI 461


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score =  212 bits (540), Expect = 9e-55
 Identities = 131/379 (34%), Positives = 197/379 (51%), Gaps = 69/379 (18%)

Query: 17  RRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG 76
           +RKEKSR+AARSRR KE+  F+ELA  LPLP  +SS LDKAS++RL+++YLR+R+    G
Sbjct: 45  QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104

Query: 77  DLD----------------------IEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
                                    + +  +  +    L++LDGFV  L  +G  +YIS+
Sbjct: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164

Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN---------------------- 152
            V+ Y+GL+Q E+TG SVFD+ HP DH E+ E L  R                       
Sbjct: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224

Query: 153 -------GLVKKGKEQNTQ-RSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTN 204
                   L K       Q RSFF+RMK TLT RG  +++K++ +KV+H TG +  +   
Sbjct: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG 282

Query: 205 SNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMG 264
                          LV +   +P     E+PL     + R SL +    C+ R+++ M 
Sbjct: 283 ---------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMD 327

Query: 265 YEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVI 324
             P EL+GRS Y++ H  D+  + ++H D+  KGQV TG YR L + GG+VW+++ ATV 
Sbjct: 328 LGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVA 387

Query: 325 YNTKNSQPQCIVCVNYVVS 343
            + K+     ++ V++V+S
Sbjct: 388 GSGKSPGEHHVLWVSHVLS 406


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score =  137 bits (345), Expect = 4e-32
 Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
           +E      + RR K +    ELA  +P  + +S  LDK +V+R+ + +++   L  A + 
Sbjct: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 88

Query: 79  DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
             E + K       ++    L+A DGF+ V+  D G ++++S++V K +  +Q +L G S
Sbjct: 89  YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 148

Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
           +FD+ HP D  +++E L+      R  L+  K G    T             +RSFF RM
Sbjct: 149 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 208

Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
           KC   S +    +  S   K         +H TG++  +         D   +   C   
Sbjct: 209 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 266

Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
              ++CLV I       +P P N EI + S  ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 267 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 323

Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
           LLG S YEY+H  D  HL + H  +  T+ ++TT  Y+   K G ++ + ++     N  
Sbjct: 324 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 383

Query: 329 NSQPQCIVCVNYVV 342
             + + IV  N VV
Sbjct: 384 TKEVEYIVSTNTVV 397


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  137 bits (345), Expect = 4e-32
 Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
           +E      + RR K +    ELA  +P  + +S  LDK +V+R+ + +++   L  A + 
Sbjct: 74  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131

Query: 79  DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
             E + K       ++    L+A DGF+ V+  D G ++++S++V K +  +Q +L G S
Sbjct: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191

Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
           +FD+ HP D  +++E L+      R  L+  K G    T             +RSFF RM
Sbjct: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251

Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
           KC   S +    +  S   K         +H TG++  +         D   +   C   
Sbjct: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309

Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
              ++CLV I       +P P N EI + S  ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366

Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
           LLG S YEY+H  D  HL + H  +  T+ ++TT  Y+   K G ++ + ++     N  
Sbjct: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426

Query: 329 NSQPQCIVCVNYVV 342
             + + IV  N VV
Sbjct: 427 TKEVEYIVSTNTVV 440


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  137 bits (345), Expect = 4e-32
 Identities = 107/374 (28%), Positives = 178/374 (47%), Gaps = 57/374 (15%)

Query: 19  KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
           +E      + RR K +    ELA  +P  + +S  LDK +V+R+ + +++   L  A + 
Sbjct: 74  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--LRGATNP 131

Query: 79  DIEDDMKA------QMNCFYLKALDGFVMVL-TDDGDMIYISDNVNKYMGLTQFELTGHS 131
             E + K       ++    L+A DGF+ V+  D G ++++S++V K +  +Q +L G S
Sbjct: 132 YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQS 191

Query: 132 VFDFTHPCDHEEMREMLTH-----RNGLV--KKGKEQNT-------------QRSFFLRM 171
           +FD+ HP D  +++E L+      R  L+  K G    T             +RSFF RM
Sbjct: 192 LFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRM 251

Query: 172 KCTLTS-RGRTMNIKSATWK--------VLHCTGHIHVY---------DTNSNQPQCGYK 213
           KC   S +    +  S   K         +H TG++  +         D   +   C   
Sbjct: 252 KCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCN-- 309

Query: 214 KPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE 269
              ++CLV I       +P P N EI + S  ++SRH++D KF + D+R T ++ Y P+E
Sbjct: 310 ---LSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQE 366

Query: 270 LLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTK 328
           LLG S YEY+H  D  HL + H  +  T+ ++TT  Y+   K G ++ + ++     N  
Sbjct: 367 LLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPW 426

Query: 329 NSQPQCIVCVNYVV 342
             + + IV  N VV
Sbjct: 427 TKEVEYIVSTNTVV 440


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score =  137 bits (344), Expect = 5e-32
 Identities = 110/385 (28%), Positives = 193/385 (50%), Gaps = 46/385 (11%)

Query: 3   GAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRL 62
           G+   + + ++  +  +E      + RR K + +  EL+  +P  + ++  LDK +V+R+
Sbjct: 93  GSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRM 152

Query: 63  TISYLRVRKLLDAGDLD-------IEDDMKAQMNCFYLKALDGFVMVL-TDDGDMIYISD 114
            + +LR  K L    +        ++D+   ++    LK  +GF+ V+  + G ++++S 
Sbjct: 153 AVQHLRSLKGLTNSYVGSNYRPSFLQDN---ELRHLILKTAEGFLFVVGCERGKILFVSK 209

Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTH-----RNGLV--KKGKE------- 160
           +V+K +   Q  LTG S+FDF HP D  +++E L+      R  L+  K G +       
Sbjct: 210 SVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHA 269

Query: 161 ------QNTQRSFFLRMK-CTLTSR---GRTMNIKSATWK---VLHCTGHIHVYDTN--S 205
                   ++RSFF R+K C ++ +   G   N K    +    +HCTG++  +  N   
Sbjct: 270 GRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVG 329

Query: 206 NQPQCGYKKPP--MTCLVLI--CEPIPHPSNI-EIPLDSKTFLSRHSLDMKFSYCDERIT 260
            + +   KK     TCLV I   +P   P N  EI +    F++R +++ KF Y D+R T
Sbjct: 330 MEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRAT 389

Query: 261 ELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVET 319
            ++GY P+ELLG S YEY+H  D ++LT  H  +  +K ++ T  Y+  AK G +V +++
Sbjct: 390 AILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKS 449

Query: 320 QATVIYNTKNSQPQCIVCVNYVVSG 344
           Q     N    + + IV VN +V G
Sbjct: 450 QWFSFTNPWTKELEYIVSVNTLVLG 474


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score =  129 bits (324), Expect = 1e-29
 Identities = 101/362 (27%), Positives = 170/362 (46%), Gaps = 43/362 (11%)

Query: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
           DK K  S  + EK R      R + + +  EL   LP     +  +DK++V++ +I +LR
Sbjct: 32  DKAKRVSRNKSEKKR------RDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLR 82

Query: 69  VRKLLDAGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM 120
             K + A     +I  D K       +     L+ALDGF + +  DG +IY+S++V   +
Sbjct: 83  KHKEITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLL 142

Query: 121 GLTQFELTGHSVFDFTHPCDHEEMREML-TH---RNGLVKKGKEQNTQRSFFLRMKCTLT 176
                +L   S+F+F    +H E+ ++L TH    + L  +  +   Q  F     C   
Sbjct: 143 EHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEF-----CCHM 197

Query: 177 SRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYK-------------KPPMTCLVLI 223
            RG     + +T++ +   G+    ++ S+    G++             +      V +
Sbjct: 198 LRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRL 257

Query: 224 CEP--IPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHA 281
             P  I     +E P  ++ F SRHSL+ KF + D R   ++GY P E+LG S Y+YYH 
Sbjct: 258 ATPQFIKEMCTVEEP--NEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHV 315

Query: 282 LDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYV 341
            D ++L K H  +   G+  +  YR L K   ++W++T   + Y+  NS+P+ IVC + V
Sbjct: 316 DDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375

Query: 342 VS 343
           VS
Sbjct: 376 VS 377


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score =  129 bits (323), Expect = 1e-29
 Identities = 99/387 (25%), Positives = 183/387 (47%), Gaps = 62/387 (16%)

Query: 7   ANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY 66
           +NDK++ + E   E      R RR+K +    EL+  +P    ++   DK +++R+ +S+
Sbjct: 68  SNDKERFARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 123

Query: 67  LRVRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKY 119
           ++   L   G+   +   K       ++    L+A DGF+ +++ + G ++Y+SD+V   
Sbjct: 124 MK--SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 181

Query: 120 MGLTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT---- 163
           +   Q E  G +++D  HP D +++RE L+             + G VKK  +Q++    
Sbjct: 182 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 241

Query: 164 ---QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY- 201
              +RSF  RM+C  +S            R R  N    +K     + V+HCTG+I  + 
Sbjct: 242 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP 301

Query: 202 ----DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFS 253
                   + P+ G  +    CLV I        P+ +++        F+SRH+++  F+
Sbjct: 302 PAGVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 359

Query: 254 YCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRG 312
           + D R    +GY+P+ELLG++I E+ H  D   L  +   +   KGQV +  +R  +K  
Sbjct: 360 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ 419

Query: 313 GYVWVETQATVIYNTKNSQPQCIVCVN 339
            ++W+ T +    N  + + + I+C N
Sbjct: 420 EWLWMRTSSFTFQNPYSDEIEYIICTN 446


>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
          Length = 824

 Score =  128 bits (322), Expect = 2e-29
 Identities = 132/523 (25%), Positives = 223/523 (42%), Gaps = 73/523 (13%)

Query: 16  ERRKEKSRDAARSRRSKESEVFY-ELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
           +R K  SR+ +  +R  +  V   EL+  LP     +  +DK +V+   I +L+    + 
Sbjct: 7   DRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEVS 63

Query: 75  AGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
           A     DI+ D K       +     L+ALDGF++ +T DG +IY+SD++   +G    +
Sbjct: 64  AQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSD 123

Query: 127 LTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKS 186
           +   ++ +F    +H E+ ++L+    +      +  +    L   C L  RG     + 
Sbjct: 124 VMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEF 182

Query: 187 ATWKVLHCTGHIHVYDTNSNQPQC-GY-------------KKPPMTCLVLICEP--IPHP 230
            T++ +   G+   Y+ N   P C G+             K+      V +  P  +   
Sbjct: 183 PTYEYIKFVGNFRSYN-NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEM 241

Query: 231 SNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKT 290
             ++ PL+   F SRHSL+ KF + D R   ++GY P E+LG S Y+YYH  D + L + 
Sbjct: 242 CIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARC 299

Query: 291 HHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL 350
           H  +   G+  +  YR L K   ++W++T   + Y+  NS+P+ IVC + VVS     D+
Sbjct: 300 HQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS---YADV 356

Query: 351 IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIIS 410
               +Q E  L+   S  +  + L  K  S +    F+                     +
Sbjct: 357 RVERRQ-ELALEDPPSEALHSSALKDKGSSLEPRQHFN---------------------T 394

Query: 411 LDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPAL 470
           LD G++   T                 S     ++ + AMS  PT+   K +  ++ PAL
Sbjct: 395 LDVGASGLNTSHSP-----------SASSRSSHKSSHTAMSE-PTSTPTKLMAEASTPAL 442

Query: 471 NQEVALKLEPNPESLELSFTMPQIQDQTPSPSD-GSTRQSSPE 512
            +   L  E     L  + TMP      PSPS    T+Q  P+
Sbjct: 443 PRSATLPQELPVPGLSQAATMPA---PLPSPSSCDLTQQLLPQ 482


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score =  127 bits (318), Expect = 5e-29
 Identities = 98/385 (25%), Positives = 182/385 (47%), Gaps = 62/385 (16%)

Query: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
           DK++++ E   E      R RR+K +    EL+  +P    ++   DK +++R+ +S+++
Sbjct: 85  DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140

Query: 69  VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
              L   G+   +   K       ++    L+A DGF+ +++ + G ++Y+SD+V   + 
Sbjct: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198

Query: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT------ 163
             Q E  G +++D  HP D +++RE L+             + G VKK  +Q++      
Sbjct: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258

Query: 164 -QRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY--- 201
            +RSF  RM+C  +S            R R  N    +K     + V+HCTG+I  +   
Sbjct: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318

Query: 202 --DTNSNQPQCGYKKPPMTCLVLI----CEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYC 255
                 + P+ G  +    CLV I        P+ +++        F+SRH+++  F++ 
Sbjct: 319 GVSLPDDDPEAG--QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFV 376

Query: 256 DERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGY 314
           D R    +GY+P+ELLG++I E+ H  D   L  +   +   KGQV +  +R  +K   +
Sbjct: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436

Query: 315 VWVETQATVIYNTKNSQPQCIVCVN 339
           +W+ T +    N  + + + I+C N
Sbjct: 437 LWMRTSSFTFQNPYSDEIEYIICTN 461


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score =  123 bits (309), Expect = 5e-28
 Identities = 105/405 (25%), Positives = 182/405 (44%), Gaps = 72/405 (17%)

Query: 15  SERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
           S+  +E   +  R RR+K ++   EL+  +P    ++   DK +++R+ +S+++   +  
Sbjct: 61  SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--SMRG 118

Query: 75  AGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMGLTQFEL 127
            G+   +   K       ++    L+A DGF+ V+  + G +IY+SD+V   +   Q E 
Sbjct: 119 TGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178

Query: 128 TGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQNT-------QRSFF 168
            G ++++  HP D E++RE L              + G VKK  +Q++       +RSF 
Sbjct: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238

Query: 169 LRMKC------------TLTSRGRTMN----IKS--ATWKVLHCTGHIHVYDTNSNQPQC 210
            RM+C              T R R  N    +K   A + V+HCTG+I  +      P  
Sbjct: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAW------PPA 292

Query: 211 GYKKPPMT---------CLVLI------CEPIPHPSN-IEIPLDSKTFLSRHSLDMKFSY 254
           G   P            CLV I        P+    N + +P +   FLSRH+ D   ++
Sbjct: 293 GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE---FLSRHNSDGIITF 349

Query: 255 CDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGG 313
            D R   ++GY+P++LLG+ I E+ H  D  HL ++   +   KGQV +  YR   K   
Sbjct: 350 VDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNRE 409

Query: 314 YVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
           ++ + T +    N  + + + I+C N  V  + Q      + Q +
Sbjct: 410 WMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRD 454


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score =  121 bits (304), Expect = 2e-27
 Identities = 97/370 (26%), Positives = 160/370 (43%), Gaps = 57/370 (15%)

Query: 11  KKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR 70
           K I +E  K       R R + E +    LA  LP P +V + LDK SV+RL++SYLR +
Sbjct: 24  KPIPAEGIKSNPSKRHRDRLNTELD---RLASLLPFPQDVINKLDKLSVLRLSVSYLRAK 80

Query: 71  KLLDAG----------------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
              D                    +  + +  Q   F L+AL+GFV+V+T D  + Y S 
Sbjct: 81  SFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASS 140

Query: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREML---THRNGLVKKGK--EQNT------ 163
            +  Y+G  Q ++   SV++  H  D  E +  L    + +   + G+  E+ T      
Sbjct: 141 TIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTV 200

Query: 164 ----------------QRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQ 207
                           +R F  R++C L +        S+ +  ++  G +        +
Sbjct: 201 VCYNPDQIPPENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKK 252

Query: 208 PQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP 267
            + G   PP   L  I  P+  PS +EI   +  F ++H LD     CD +   ++GY  
Sbjct: 253 GKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTE 312

Query: 268 EELLGR-SIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYN 326
            EL  R S Y++ HA D  +  ++H  M   G+     +R+L K   + WV++ A ++Y 
Sbjct: 313 AELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY- 371

Query: 327 TKNSQPQCIV 336
            KN +P  I+
Sbjct: 372 -KNGRPDYII 380


>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
          Length = 802

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)

Query: 22  SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81
           ++ A+++RR + +     L   LPL       L    +M L   Y R + +  AG   + 
Sbjct: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63

Query: 82  DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136
                + AQ     + AL GF++V T +G ++Y+S++V++++G +  +L   G S++D  
Sbjct: 64  GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123

Query: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196
            P DH  +R+ LT  + L       +T R F  R   +     +++  +SA  K++   G
Sbjct: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171

Query: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250
             H +      P   Y    P  T      EP P P     P  +  FL    SRH+ D+
Sbjct: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225

Query: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308
                 E +   +G+E  ELL +S Y   H  D  H +  H+ +  +      +   R+ 
Sbjct: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285

Query: 309 AKRGGYVWV 317
           AK GG+ W+
Sbjct: 286 AKTGGWAWI 294


>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
          Length = 1464

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 84/405 (20%), Positives = 172/405 (42%), Gaps = 63/405 (15%)

Query: 1   MEGAG-GANDKKKISSERRKE--------KSRDAARSRRSKESEVFYELAHQLPLPHNVS 51
           M G G   +D  +  + +RKE          R+  +  R +E++   ELA  +    N  
Sbjct: 1   MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60

Query: 52  SHL----DKASVMRLTISYLR-VRKLLDAGDLDIEDDMKAQMNC-------------FYL 93
            +     DK ++++ T+  +R +++   A   +I++  K+ ++                L
Sbjct: 61  DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120

Query: 94  KALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR-- 151
           +ALDGF  V+  +G+++++S+NV +Y+   Q EL   SV+   H  DH E  + L  +  
Sbjct: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180

Query: 152 -NGLVKKGK-EQNTQRSFFLRMKC----TLTSRGRTMNIKSATWKVLHCTGHIHVYDTNS 205
            NG    G+  +    +F  RM           G         ++ + C           
Sbjct: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA--------V 232

Query: 206 NQPQCGYKKPP--MTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELM 263
           +QP+   ++     +CL+ +   +P      +P  S++F +R  L  K +  D   T   
Sbjct: 233 SQPKSIKEEGEDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRA 290

Query: 264 GYEP--EELLGRSIYEYYHALDSDHLT---KTHHDMFTKGQVTTGQYRMLAKRGGYVWVE 318
             +P  E+L+ R I +++   + + ++   + HH++  +G   +  YR     G  V  +
Sbjct: 291 AMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQ 350

Query: 319 TQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
           T++ +I +   ++PQ ++ ++           +   +Q  CV+ P
Sbjct: 351 TKSKLIRSQTTNEPQLVISLH-----------MLHREQNVCVMNP 384


>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
          Length = 1399

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)

Query: 1   MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
           M G G  ++D     S +RK    D   S     RR +E++   ELA  L        ++
Sbjct: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 51  SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
           S   DK  +++ T+  +++ K ++      +DD+              K  +    L+AL
Sbjct: 61  SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 97  DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
           DGF  V+  +G ++++S+NV  Y+G  Q EL   SV+   H  DH E  + L  +   NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
           +   +   +    +F  RM         T N ++   ++V+ C     V    S Q    
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235

Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
             +   +CL+ I   +P P  I      ++F+++     K    D       G    E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291

Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
           + + IY ++     +  +  +   ++ T+G  ++  YR +   G  +   T+  + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348


>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
          Length = 1440

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)

Query: 1   MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
           M G G  ++D     S +RK    D   S     RR +E++   ELA  L        ++
Sbjct: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 51  SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
           S   DK  +++ T+  +++ K ++      +DD+              K  +    L+AL
Sbjct: 61  SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 97  DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
           DGF  V+  +G ++++S+NV  Y+G  Q EL   SV+   H  DH E  + L  +   NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
           +   +   +    +F  RM         T N ++   ++V+ C     V    S Q    
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235

Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
             +   +CL+ I   +P P  I      ++F+++     K    D       G    E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291

Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
           + + IY ++     +  +  +   ++ T+G  ++  YR +   G  +   T+  + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348


>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
          Length = 1441

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)

Query: 1   MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
           M G G  ++D     S +RK    D   S     RR +E++   ELA  L        ++
Sbjct: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 51  SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
           S   DK  +++ T+  +++ K ++      +DD+              K  +    L+AL
Sbjct: 61  SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 97  DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
           DGF  V+  +G ++++S+NV  Y+G  Q EL   SV+   H  DH E  + L  +   NG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
           +   +   +    +F  RM         T N ++   ++V+ C     V    S Q    
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235

Query: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
             +   +CL+ I   +P P  I      ++F+++     K    D       G    E+L
Sbjct: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291

Query: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
           + + IY ++     +  +  +   ++ T+G  ++  YR +   G  +   T+  + Y
Sbjct: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 60/237 (25%), Positives = 112/237 (47%), Gaps = 50/237 (21%)

Query: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68
           DK++++ E   E      R RR+K +    EL+  +P    ++   DK +++R+ +S+++
Sbjct: 85  DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140

Query: 69  VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121
              L   G+   +   K       ++    L+A DGF+ +++ + G ++Y+SD+V   + 
Sbjct: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198

Query: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQN------- 162
             Q E  G +++D  HP D +++RE L+             + G VKK  +Q+       
Sbjct: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258

Query: 163 TQRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY 201
           ++RSF  RM+C  +S            R R  N    +K     + V+HCTG+I  +
Sbjct: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315


>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
          Length = 1424

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 145/750 (19%), Positives = 277/750 (36%), Gaps = 81/750 (10%)

Query: 27  RSRRSKESEVFYELAHQLPLP----HNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIED 82
           + RR +ES+   ELA  +        N +   DK ++++ T+   ++R++ + G     D
Sbjct: 35  KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTISND 92

Query: 83  DM---------------KAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFEL 127
           D                K  +    L+ALDGF+ V+  DG+++++S+NV +Y+   Q +L
Sbjct: 93  DDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDL 152

Query: 128 TGHSVFDFTHPCDHEEMREMLTHR--NGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIK 185
              SV++  H  D ++  + L     NG V    E   Q+S     +  + +    +   
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNG-VSWTNETQRQKSHTFNCRMLMKTPHDILEDI 211

Query: 186 SATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSR 245
           +A+ ++      +  +  +  +      +   +C++ +   I        P + ++F++R
Sbjct: 212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITR 270

Query: 246 HSLDMKFSYCD-ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHH--DMFTKGQVTT 302
           H L  K    D   +   M    E+++ R I  ++   D    ++  H  + +  G   T
Sbjct: 271 HDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAET 330

Query: 303 GQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNY--------------VVSGIIQH 348
             YR     G  V  +T++ +  N   +     V  ++              V  GI   
Sbjct: 331 PVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPP 390

Query: 349 DLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG--- 405
               +       + P +   M  ++ +   +   T  +          +  L P  G   
Sbjct: 391 MAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQS 450

Query: 406 -DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRS 464
             +  + ++G N +          P   ++M+ SP  +      +    P A    P+ S
Sbjct: 451 PSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMI-SPRNRGSPKIASHQFSPVAGVHSPMAS 509

Query: 465 SADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPS-DGSTRQSSPEP------NSPS 517
           S +   +   +  L       E   T       +P P  D S   +  +P      +S S
Sbjct: 510 SGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKS 569

Query: 518 EYCFYVDSDMVNEFKLELVEKLFAEDTEAKNP----FSTQDTDLDL---EMLAPYIPMDD 570
              FY D + V     +   +    D E+K         Q   L+    + L   +    
Sbjct: 570 PLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSS 629

Query: 571 DFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD 630
           D +  S    SPL+SS         +S+V+V   + +   T+   ++T+         K 
Sbjct: 630 DDRGHSSLTNSPLDSS-------CKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKH 682

Query: 631 RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSP-- 688
           R+   K+L    SP  + K T  AT    +DT S T+     G G + + E+  P+    
Sbjct: 683 RILH-KLLQNGNSPAEVAKITAEATG---KDTSSITS----CGDGNVVKQEQLSPKKKEN 734

Query: 689 NVLSVALSQR---TTVPEEELNPKILALQN 715
           N L   L  R   +    +EL P++  + N
Sbjct: 735 NALLRYLLDRDDPSDALSKELQPQVEGVDN 764


>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
          Length = 1420

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 145/750 (19%), Positives = 277/750 (36%), Gaps = 81/750 (10%)

Query: 27  RSRRSKESEVFYELAHQLPLP----HNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIED 82
           + RR +ES+   ELA  +        N +   DK ++++ T+   ++R++ + G     D
Sbjct: 35  KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTISND 92

Query: 83  DM---------------KAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFEL 127
           D                K  +    L+ALDGF+ V+  DG+++++S+NV +Y+   Q +L
Sbjct: 93  DDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDL 152

Query: 128 TGHSVFDFTHPCDHEEMREMLTHR--NGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIK 185
              SV++  H  D ++  + L     NG V    E   Q+S     +  + +    +   
Sbjct: 153 VNTSVYNILHEEDRKDFLKNLPKSTVNG-VSWTNETQRQKSHTFNCRMLMKTPHDILEDI 211

Query: 186 SATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSR 245
           +A+ ++      +  +  +  +      +   +C++ +   I        P + ++F++R
Sbjct: 212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESFITR 270

Query: 246 HSLDMKFSYCD-ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHH--DMFTKGQVTT 302
           H L  K    D   +   M    E+++ R I  ++   D    ++  H  + +  G   T
Sbjct: 271 HDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAET 330

Query: 303 GQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNY--------------VVSGIIQH 348
             YR     G  V  +T++ +  N   +     V  ++              V  GI   
Sbjct: 331 PVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPP 390

Query: 349 DLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG--- 405
               +       + P +   M  ++ +   +   T  +          +  L P  G   
Sbjct: 391 MAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQS 450

Query: 406 -DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRS 464
             +  + ++G N +          P   ++M+ SP  +      +    P A    P+ S
Sbjct: 451 PSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMI-SPRNRGSPKIASHQFSPVAGVHSPMAS 509

Query: 465 SADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPS-DGSTRQSSPEP------NSPS 517
           S +   +   +  L       E   T       +P P  D S   +  +P      +S S
Sbjct: 510 SGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKS 569

Query: 518 EYCFYVDSDMVNEFKLELVEKLFAEDTEAKNP----FSTQDTDLDL---EMLAPYIPMDD 570
              FY D + V     +   +    D E+K         Q   L+    + L   +    
Sbjct: 570 PLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSS 629

Query: 571 DFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD 630
           D +  S    SPL+SS         +S+V+V   + +   T+   ++T+         K 
Sbjct: 630 DDRGHSSLTNSPLDSS-------CKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKH 682

Query: 631 RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSP-- 688
           R+   K+L    SP  + K T  AT    +DT S T+     G G + + E+  P+    
Sbjct: 683 RILH-KLLQNGNSPAEVAKITAEATG---KDTSSITS----CGDGNVVKQEQLSPKKKEN 734

Query: 689 NVLSVALSQR---TTVPEEELNPKILALQN 715
           N L   L  R   +    +EL P++  + N
Sbjct: 735 NALLRYLLDRDDPSDALSKELQPQVEGVDN 764


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,511,630
Number of Sequences: 37866
Number of extensions: 1388992
Number of successful extensions: 5705
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 4857
Number of HSP's gapped (non-prelim): 826
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.