Search of human proteins with 30795240

Search of human proteins with 30795240

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30795240 aryl hydrocarbon receptor nuclear translocator
isoform 2 [Homo sapiens]
         (328 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...   662   0.0  
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...   661   0.0  
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...   621   e-178
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...   439   e-123
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...   237   1e-62
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...   237   1e-62
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...   237   1e-62
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...   198   6e-51
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]            78   9e-15
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]               77   3e-14
gi|4758010 clock [Homo sapiens]                                        74   2e-13
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...    74   2e-13
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...    74   2e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]    72   9e-13
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]    72   9e-13
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]    72   9e-13
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]     71   2e-12
gi|21614542 single-minded homolog 1 [Homo sapiens]                     69   7e-12
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]         69   7e-12
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]      69   7e-12
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]               65   8e-11
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...    65   8e-11
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...    64   1e-10
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]    63   3e-10
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]    63   3e-10
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]         62   7e-10
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]     62   9e-10
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                    57   2e-08
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]               56   4e-08
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]              50   3e-06

>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score =  662 bits (1709), Expect = 0.0
 Identities = 328/328 (100%), Positives = 328/328 (100%)

Query: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
           MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60

Query: 61  RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
           RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61  RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120

Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
           ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180

Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
           CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240

Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
           TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300

Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPA 328
           PHFVVVHCTGYIKAWPPAGVSLPDDDPA
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPA 328


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score =  661 bits (1705), Expect = 0.0
 Identities = 327/327 (100%), Positives = 327/327 (100%)

Query: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
           MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60

Query: 61  RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
           RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61  RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120

Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
           ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180

Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
           CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240

Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
           TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300

Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327
           PHFVVVHCTGYIKAWPPAGVSLPDDDP
Sbjct: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score =  621 bits (1601), Expect = e-178
 Identities = 311/327 (95%), Positives = 311/327 (95%), Gaps = 15/327 (4%)

Query: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60
           MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
Sbjct: 1   MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL 60

Query: 61  RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120
           RCDDDQMSND               KER ARENHSEIERRRRNKMTAYITELSDMVPTCS
Sbjct: 61  RCDDDQMSND---------------KERFARENHSEIERRRRNKMTAYITELSDMVPTCS 105

Query: 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180
           ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
Sbjct: 106 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 165

Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 240
           CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
Sbjct: 166 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK 225

Query: 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 300
           TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
Sbjct: 226 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGE 285

Query: 301 PHFVVVHCTGYIKAWPPAGVSLPDDDP 327
           PHFVVVHCTGYIKAWPPAGVSLPDDDP
Sbjct: 286 PHFVVVHCTGYIKAWPPAGVSLPDDDP 312


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score =  439 bits (1130), Expect = e-123
 Identities = 224/325 (68%), Positives = 257/325 (79%), Gaps = 40/325 (12%)

Query: 8   PEMTSDVPS-----LGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDD-DGEGNSKFLR 61
           PEM SD+P      + P  A+G     ++  GA+  R  KRR G+DFDD DGEG SKF  
Sbjct: 10  PEMASDIPGSVTLPVAPMAATGQ----VRMAGAMPARGGKRRSGMDFDDEDGEGPSKF-- 63

Query: 62  CDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSA 121
                                       +RENHSEIERRRRNKMT YITELSDMVPTCSA
Sbjct: 64  ----------------------------SRENHSEIERRRRNKMTQYITELSDMVPTCSA 95

Query: 122 LARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSC 181
           LARKPDKLTILRMAVSHMKS+RGTGN STDG+YKPSFLT+QELKHLILEAADGFLF+V+ 
Sbjct: 96  LARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAA 155

Query: 182 ETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKT 241
           ETGRV+YVSDSVTPVLNQPQSEWFGSTLY+QVHPDDV+KLREQL TSEN++TGRILDLKT
Sbjct: 156 ETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKT 215

Query: 242 GTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEP 301
           GTVKKEGQQSSMRMCMGSRRSFICRMRCG++ +D + +NR++ +R R RNGLG VK+GE 
Sbjct: 216 GTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEA 275

Query: 302 HFVVVHCTGYIKAWPPAGVSLPDDD 326
            + VVHCTGYIKAWPPAG+++P++D
Sbjct: 276 QYAVVHCTGYIKAWPPAGMTIPEED 300


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score =  237 bits (604), Expect = 1e-62
 Identities = 116/238 (48%), Positives = 164/238 (68%), Gaps = 10/238 (4%)

Query: 90  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 30  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 89

Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 90  TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 149

Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 150 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 209

Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDD 326
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+
Sbjct: 210 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDN 258



 Score = 32.0 bits (71), Expect = 0.77
 Identities = 21/79 (26%), Positives = 35/79 (44%), Gaps = 11/79 (13%)

Query: 166 HLILEAADGFLFIVSCE-------TGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 218
           H++ +  +G + + S E        G+ V+V    T +L     E  G++ Y+  H DD+
Sbjct: 279 HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDI 338

Query: 219 DKL----REQLSTSENALT 233
             L    R+ L T E   T
Sbjct: 339 GHLAECHRQVLQTREKITT 357


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  237 bits (604), Expect = 1e-62
 Identities = 116/238 (48%), Positives = 164/238 (68%), Gaps = 10/238 (4%)

Query: 90  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 73  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132

Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192

Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252

Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDD 326
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDN 301



 Score = 32.0 bits (71), Expect = 0.77
 Identities = 21/79 (26%), Positives = 35/79 (44%), Gaps = 11/79 (13%)

Query: 166 HLILEAADGFLFIVSCE-------TGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 218
           H++ +  +G + + S E        G+ V+V    T +L     E  G++ Y+  H DD+
Sbjct: 322 HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDI 381

Query: 219 DKL----REQLSTSENALT 233
             L    R+ L T E   T
Sbjct: 382 GHLAECHRQVLQTREKITT 400


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  237 bits (604), Expect = 1e-62
 Identities = 116/238 (48%), Positives = 164/238 (68%), Gaps = 10/238 (4%)

Query: 90  ARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTS 149
           ARE HS+IE+RRR+KM ++I EL+ +VPTC+A++RK DKLT+LRMAV HMK+LRG  N  
Sbjct: 73  AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPY 132

Query: 150 TDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTL 209
           T+ +YKP+FL+D ELKHLIL AADGFLF+V C+ G++++VS+SV  +LN  Q++  G +L
Sbjct: 133 TEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSL 192

Query: 210 YDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFICRMR 268
           +D +HP D+ K++EQLS+S+ A   R++D KTG  VK +      R+C G+RRSF CRM+
Sbjct: 193 FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMK 252

Query: 269 CGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDD 326
           C   SV          V ++      S K     F  +H TGY+K+WPP  + L +D+
Sbjct: 253 CNRPSVK---------VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDN 301



 Score = 32.0 bits (71), Expect = 0.77
 Identities = 21/79 (26%), Positives = 35/79 (44%), Gaps = 11/79 (13%)

Query: 166 HLILEAADGFLFIVSCE-------TGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 218
           H++ +  +G + + S E        G+ V+V    T +L     E  G++ Y+  H DD+
Sbjct: 322 HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDI 381

Query: 219 DKL----REQLSTSENALT 233
             L    R+ L T E   T
Sbjct: 382 GHLAECHRQVLQTREKITT 400


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score =  198 bits (503), Expect = 6e-51
 Identities = 104/241 (43%), Positives = 151/241 (62%), Gaps = 12/241 (4%)

Query: 86  KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGT 145
           K +  RE HS+ E+RRR+KM   I ELS M+P C+ +ARK DKLT+LRMAV H++SL+G 
Sbjct: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163

Query: 146 GNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
            N+    +Y+PSFL D EL+HLIL+ A+GFLF+V CE G++++VS SV+ +LN  Q+   
Sbjct: 164 TNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 223

Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFI 264
           G +L+D +HP DV K++EQLS+ + +   +++D KTG  V         R+  GSRRSF 
Sbjct: 224 GQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFF 283

Query: 265 CRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPD 324
           CR++    SV            + C     S K     F  +HCTGY+++WPP  V + +
Sbjct: 284 CRIKSCKISVKE---------EHGCLP--NSKKKEHRKFYTIHCTGYLRSWPPNIVGMEE 332

Query: 325 D 325
           +
Sbjct: 333 E 333



 Score = 32.7 bits (73), Expect = 0.45
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 184 GRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD----VDKLREQLSTSENALT 233
           G+ VYV    T +L     E  G++ Y+  H DD     DK +  L + E  LT
Sbjct: 379 GKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILT 432


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 62/239 (25%), Positives = 119/239 (49%), Gaps = 39/239 (16%)

Query: 77  SDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
           +D E+  +  ER  +E   +  R RR+K T    EL+  +P   +++   DK +I+R+A+
Sbjct: 3   ADKEKKRSSSER-RKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAI 61

Query: 137 SHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPV 196
           S +++ +   +  ++   +     DQ++ +L L+A +GF+ +V+ + G ++++S++++  
Sbjct: 62  SFLRTHKLLSSVCSENESEAE--ADQQMDNLYLKALEGFIAVVT-QDGDMIFLSENISKF 118

Query: 197 LNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMC 256
           +   Q E  G +++D  HP D +++RE LS            LK G+    G++S     
Sbjct: 119 MGLTQVELTGHSIFDFTHPCDHEEIRENLS------------LKNGS--GFGKKSK---D 161

Query: 257 MGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315
           M + R F  RM+C               V NR R    +V      + V+HCTG +K +
Sbjct: 162 MSTERDFFMRMKC--------------TVTNRGR----TVNLKSATWKVLHCTGQVKVY 202


>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
          Length = 824

 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 47/147 (31%), Positives = 80/147 (54%), Gaps = 8/147 (5%)

Query: 85  DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HMK 140
           +K+R  R + ++ E++RR++    I ELS M+P      RK DK T+L   +     H +
Sbjct: 5   EKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNE 61

Query: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
               T        +KPSFL+++E   L+LEA DGF+  V+ + G ++YVSDS+TP+L   
Sbjct: 62  VSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHL 120

Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLST 227
            S+     L + +   +  ++ + LS+
Sbjct: 121 PSDVMDQNLLNFLPEQEHSEVYKILSS 147


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 45/148 (30%), Positives = 84/148 (56%), Gaps = 10/148 (6%)

Query: 85  DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRG 144
           DK++  R + ++ E++RR++    I EL  M+P     ARK DK T+L+ ++  ++  + 
Sbjct: 30  DKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKE 86

Query: 145 TGNTSTDGS-----YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQ 199
                +D S     +KP+FL+++E   L+LEA DGF F+     G ++YVS+SVT +L  
Sbjct: 87  I-TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGF-FLAIMTDGSIIYVSESVTSLLEH 144

Query: 200 PQSEWFGSTLYDQVHPDDVDKLREQLST 227
             S+    ++++ +   +  ++ + LST
Sbjct: 145 LPSDLVDQSIFNFIPEGEHSEVYKILST 172


>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 60/237 (25%), Positives = 112/237 (47%), Gaps = 50/237 (21%)

Query: 85  DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
           DK++++ E   E      R RR+K +    EL+  +P    ++   DK +++R+ +S+++
Sbjct: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68

Query: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
              L   G+   +   K       ++    L+A DGF+ +++ + G ++Y+SD+V   + 
Sbjct: 69  VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121

Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
             Q E  G +++D  HP D +++RE L+             + G VKK  +Q+       
Sbjct: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQN------- 162

Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315
           ++RSF  RM+C  +S            R R  N    +K     + V+HCTG+I  +
Sbjct: 163 TQRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY 201


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 60/237 (25%), Positives = 112/237 (47%), Gaps = 50/237 (21%)

Query: 85  DKERLARENHSE----IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
           DK++++ E   E      R RR+K +    EL+  +P    ++   DK +++R+ +S+++
Sbjct: 9   DKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLR 68

Query: 141 --SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
              L   G+   +   K       ++    L+A DGF+ +++ + G ++Y+SD+V   + 
Sbjct: 69  VRKLLDAGDLDIEDDMKA------QMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMG 121

Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
             Q E  G +++D  HP D +++RE L+             + G VKK  +Q+       
Sbjct: 122 LTQFELTGHSVFDFTHPCDHEEMREMLTH------------RNGLVKKGKEQN------- 162

Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW 315
           ++RSF  RM+C  +S            R R  N    +K     + V+HCTG+I  +
Sbjct: 163 TQRSFFLRMKCTLTS------------RGRTMN----IKSAT--WKVLHCTGHIHVY 201


>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
          Length = 1399

 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 15/137 (10%)

Query: 95  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 201 QSEWFGSTLYDQVHPDD 217
           Q E   +++Y  +H  D
Sbjct: 148 QEELMNTSVYSILHVGD 164


>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
          Length = 1440

 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 15/137 (10%)

Query: 95  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 201 QSEWFGSTLYDQVHPDD 217
           Q E   +++Y  +H  D
Sbjct: 148 QEELMNTSVYSILHVGD 164


>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
          Length = 1441

 Score = 71.6 bits (174), Expect = 9e-13
 Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 15/137 (10%)

Query: 95  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88

Query: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147

Query: 201 QSEWFGSTLYDQVHPDD 217
           Q E   +++Y  +H  D
Sbjct: 148 QEELMNTSVYSILHVGD 164


>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 55/171 (32%), Positives = 93/171 (54%), Gaps = 26/171 (15%)

Query: 80  EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
           +Q  + +ERL    +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +
Sbjct: 9   QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68

Query: 137 SHMK------------SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADG 174
           S++K            +LR  G   NTS  G+ +   PS L  +  + HL   IL++ DG
Sbjct: 69  SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128

Query: 175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL 225
           F+F ++ E G+ +Y+S++V+  L   Q E  GS+++D VHP D  ++ EQL
Sbjct: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 55/228 (24%), Positives = 101/228 (44%), Gaps = 44/228 (19%)

Query: 91  RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 146
           +E      R RR K  +   EL+ ++P  SA+  + DK +I+R+  S++K       G G
Sbjct: 2   KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61

Query: 147 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
                 S   P     +EL   +L+  DGF+F+V+ + G+++Y+S++ +  L   Q E  
Sbjct: 62  EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120

Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
           G+++Y+ +HP D D++   L+  +   +  + + +                    RSF  
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162

Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIK 313
           RM+C  +                 +   G    G   + V+HC+GY+K
Sbjct: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLK 190


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 57/228 (25%), Positives = 102/228 (44%), Gaps = 44/228 (19%)

Query: 91  RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
           +E      + RR K      EL+ ++P  SA+  + DK +I+R+  S++K          
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
           D   +PS         +EL   +L+  DGF+F+V+ + G+++Y+S++ +  L   Q E  
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120

Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
           G+++Y+ +HP D D++   L T+   L   +L           Q+  +       RSF  
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162

Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIK 313
           RM+C  +                 +   G    G   + V+HC+GY+K
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK 190


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 57/228 (25%), Positives = 102/228 (44%), Gaps = 44/228 (19%)

Query: 91  RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
           +E      + RR K      EL+ ++P  SA+  + DK +I+R+  S++K          
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
           D   +PS         +EL   +L+  DGF+F+V+ + G+++Y+S++ +  L   Q E  
Sbjct: 62  DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120

Query: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
           G+++Y+ +HP D D++   L T+   L   +L           Q+  +       RSF  
Sbjct: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162

Query: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIK 313
           RM+C  +                 +   G    G   + V+HC+GY+K
Sbjct: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK 190


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 45/153 (29%), Positives = 80/153 (52%), Gaps = 19/153 (12%)

Query: 91  RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 140
           +E      R RR K      EL+ ++P   A++ + DK +I+R++V++++          
Sbjct: 47  KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106

Query: 141 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 192
              LR  G  +    G   P+ L     +Q L   IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165

Query: 193 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL 225
           V+  L   Q E  GS+++D +HP D  ++ EQL
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQL 198


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 60/253 (23%), Positives = 114/253 (45%), Gaps = 46/253 (18%)

Query: 79  DEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 138
           D Q       L +E   +  R RR++ T  + +L+  +P    ++   DK +I+R+ +S+
Sbjct: 2   DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61

Query: 139 MKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
           ++  R        G +       + L    L+A +GF+ +++ E G + Y+S++V+  L 
Sbjct: 62  LRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLG 116

Query: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
             Q E  G +++D +HP D ++L++ L T +  L+ R ++  T                 
Sbjct: 117 LSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT----------------- 158

Query: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW-PP 317
             R F  RM+   +S            R R  N   +       + V++C+G+++A+ PP
Sbjct: 159 -ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPP 199

Query: 318 AGVS---LPDDDP 327
           A  S    PD +P
Sbjct: 200 AQTSPAGSPDSEP 212


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 59/251 (23%), Positives = 114/251 (45%), Gaps = 46/251 (18%)

Query: 81  QSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140
           Q +     L +E   +  R RR++ T  + +L+  +P    ++   DK +I+R+ +S+++
Sbjct: 6   QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65

Query: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
             R        G +       + L    L+A +GF+ +++ E G + Y+S++V+  L   
Sbjct: 66  MHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLS 120

Query: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
           Q E  G +++D +HP D ++L++ L T +  L+ R ++  T                   
Sbjct: 121 QLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------E 161

Query: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAW-PPAG 319
           R F  RM+   +S            R R  N   +       + V++C+G+++A+ PPA 
Sbjct: 162 RCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQ 203

Query: 320 VS---LPDDDP 327
            S    PD +P
Sbjct: 204 TSPAGSPDSEP 214


>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
          Length = 1424

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 14/133 (10%)

Query: 98  ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 151
           E+RRR + + YI EL++++            KPDK  IL+  V  ++ ++  G T ++  
Sbjct: 34  EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93

Query: 152 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 204
                   S     +    L  L+L+A DGFLF+V+   G +V+VS++VT  L   Q + 
Sbjct: 94  DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152

Query: 205 FGSTLYDQVHPDD 217
             +++Y+ +H +D
Sbjct: 153 VNTSVYNILHEED 165


>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
          Length = 1420

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 14/133 (10%)

Query: 98  ERRRRNKMTAYITELSDMVPT----CSALARKPDKLTILRMAVSHMKSLRGTGNTSTD-- 151
           E+RRR + + YI EL++++            KPDK  IL+  V  ++ ++  G T ++  
Sbjct: 34  EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93

Query: 152 -------GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEW 204
                   S     +    L  L+L+A DGFLF+V+   G +V+VS++VT  L   Q + 
Sbjct: 94  DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVN-RDGNIVFVSENVTQYLQYKQEDL 152

Query: 205 FGSTLYDQVHPDD 217
             +++Y+ +H +D
Sbjct: 153 VNTSVYNILHEED 165


>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
          Length = 719

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 50/204 (24%), Positives = 88/204 (43%), Gaps = 35/204 (17%)

Query: 95  SEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK------------SL 142
           S   +R R+++ A +  L+ ++P    +  K DKL++LR++VS+++            S 
Sbjct: 34  SNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSR 93

Query: 143 RGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQS 202
           +      + G   P   +      L+LE+ +GF  +VS E G + Y S ++   L   Q+
Sbjct: 94  QPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAE-GTIFYASATIVDYLGFHQT 152

Query: 203 EWFGSTLYDQVHPDDVDKLREQ-----------------LSTSENALTGRILDLKTGTVK 245
           +     +YD +H DD      Q                 L T ++A+ GR+L       +
Sbjct: 153 DVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLL-----RAQ 207

Query: 246 KEGQQSSMRMCMGSRRSFICRMRC 269
           + G  +         R FICR+RC
Sbjct: 208 EWGTGTPTEYSAFLTRCFICRVRC 231


>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
          Length = 920

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 55/190 (28%), Positives = 91/190 (47%), Gaps = 45/190 (23%)

Query: 80  EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136
           +Q  + +ERL    +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +
Sbjct: 9   QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68

Query: 137 SHMK------------SLRGTG---NTSTDGSY----------------------KPSFL 159
           S++K            +LR  G   NTS  G                         PS L
Sbjct: 69  SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSAL 128

Query: 160 TDQELK-HL---ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHP 215
             +  + HL   IL++ DGF+F ++ E G+ +Y+S++V+  L   Q E  GS+++D VHP
Sbjct: 129 AIEVFEAHLGSHILQSLDGFVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHP 187

Query: 216 DDVDKLREQL 225
            D  ++ EQL
Sbjct: 188 GDHVEMAEQL 197


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 48/195 (24%), Positives = 89/195 (45%), Gaps = 21/195 (10%)

Query: 95  SEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH----------MKSLRG 144
           S   +R R+++   +  L+ ++P    +  K DKL++LR++VS+          +KS   
Sbjct: 33  SNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPT 92

Query: 145 TGNTSTDGSYKPSFLTDQELK--HLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQS 202
             N   D     +F     L+    +L+A +GF+ +V+ +   V Y S ++   L   QS
Sbjct: 93  ERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTD-ALVFYASSTIQDYLGFQQS 151

Query: 203 EWFGSTLYDQVHPDDVDKLREQ----LSTSENALTGRILDLKTG----TVKKEGQQSSMR 254
           +    ++Y+ +H +D  + + Q    L+ S+   +G+ ++  TG     V     Q    
Sbjct: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211

Query: 255 MCMGSRRSFICRMRC 269
                 R FICR+RC
Sbjct: 212 NSPLMERCFICRLRC 226


>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
          Length = 1464

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 15/157 (9%)

Query: 75  ARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMV----PTCSALARKPDKLT 130
           +R++  +     ++L        E+R R +   YI EL++++            KPDK  
Sbjct: 12  SRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCA 71

Query: 131 ILRMAVSHMKSLRGTGNTS---------TDGSYKPSFLTDQE-LKHLILEAADGFLFIVS 180
           IL+  V  ++ ++     +         +D S     + D++ L  ++LEA DGF F+V+
Sbjct: 72  ILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVN 131

Query: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD 217
            E G VV+VS++VT  L   Q E    ++Y  +H  D
Sbjct: 132 LE-GNVVFVSENVTQYLRYNQEELMNKSVYSILHVGD 167


>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
          Length = 802

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 7/157 (4%)

Query: 99  RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 157
           + RR+++ A I  L +++P   A   +   L I+ +A  +  K +   G T   G     
Sbjct: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67

Query: 158 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 215
            L+ QEL+ ++  A  GFL + + E G+++Y+S+SV+  L     +    G ++YD + P
Sbjct: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125

Query: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSS 252
            D   +R+QL+      T R+   +  T K   +QS+
Sbjct: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSA 162


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,019,838
Number of Sequences: 37866
Number of extensions: 587508
Number of successful extensions: 2571
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2410
Number of HSP's gapped (non-prelim): 189
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.