Guide to the Human Genome
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Search of human proteins with 30795204

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
         (1069 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]           2123   0.0  
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]           2112   0.0  
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]           1994   0.0  
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]           1702   0.0  
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]           1173   0.0  
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]           1173   0.0  
gi|153085395 histone deacetylase 4 [Homo sapiens]                    1143   0.0  
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]            1121   0.0  
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]           674   0.0  
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]           652   0.0  
gi|13128864 histone deacetylase 6 [Homo sapiens]                      282   1e-75
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]           236   1e-61
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]          202   1e-51
gi|116284376 histone deacetylase 2 [Homo sapiens]                     111   3e-24
gi|13128860 histone deacetylase 1 [Homo sapiens]                      110   7e-24
gi|8923769 histone deacetylase 8 [Homo sapiens]                       107   5e-23
gi|13128862 histone deacetylase 3 [Homo sapiens]                       90   1e-17
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]           67   7e-11
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]           67   7e-11
gi|221139761 zinc finger protein 853 [Homo sapiens]                    66   2e-10
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       63   2e-09
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   59   3e-08
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    58   4e-08
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]       58   5e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    55   3e-07
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 55   4e-07
gi|22538413 forkhead box P2 isoform III [Homo sapiens]                 55   5e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    54   8e-07
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre...    54   1e-06
gi|33286444 mastermind-like 2 [Homo sapiens]                           53   1e-06

>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
          Length = 1069

 Score = 2123 bits (5500), Expect = 0.0
 Identities = 1069/1069 (100%), Positives = 1069/1069 (100%)

Query: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
            MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
            KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120

Query: 121  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
            HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 121  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180

Query: 181  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
            TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 181  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240

Query: 241  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
            RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 241  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300

Query: 301  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
            PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 301  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360

Query: 361  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
            LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 361  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420

Query: 421  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
            LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 421  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480

Query: 481  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
            YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 481  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540

Query: 541  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
            TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 541  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600

Query: 601  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
            DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 601  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660

Query: 661  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
            AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 661  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720

Query: 721  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
            LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 721  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780

Query: 781  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
            RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 781  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840

Query: 841  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
            LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 841  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900

Query: 901  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
            VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 901  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960

Query: 961  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
            LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP
Sbjct: 961  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020

Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
            RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069


>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
          Length = 1066

 Score = 2112 bits (5472), Expect = 0.0
 Identities = 1066/1069 (99%), Positives = 1066/1069 (99%), Gaps = 3/1069 (0%)

Query: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
            MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
            KQLLIAEFQKQHENLTRQHQAQLQEHIK   ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117

Query: 121  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
            HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177

Query: 181  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
            TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237

Query: 241  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
            RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297

Query: 301  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
            PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357

Query: 361  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
            LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417

Query: 421  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
            LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477

Query: 481  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
            YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537

Query: 541  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
            TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597

Query: 601  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
            DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657

Query: 661  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
            AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717

Query: 721  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
            LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777

Query: 781  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
            RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837

Query: 841  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
            LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 838  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897

Query: 901  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
            VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 898  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957

Query: 961  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
            LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP
Sbjct: 958  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1017

Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
            RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1018 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066


>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
          Length = 1011

 Score = 1994 bits (5165), Expect = 0.0
 Identities = 1005/1008 (99%), Positives = 1005/1008 (99%), Gaps = 3/1008 (0%)

Query: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
            MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1    MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
            KQLLIAEFQKQHENLTRQHQAQLQEHIK   ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61   KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117

Query: 121  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
            HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118  HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177

Query: 181  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
            TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178  TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237

Query: 241  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
            RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238  RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297

Query: 301  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
            PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298  PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357

Query: 361  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
            LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358  LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417

Query: 421  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
            LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418  LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477

Query: 481  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
            YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478  YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537

Query: 541  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
            TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538  TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597

Query: 601  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
            DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598  DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657

Query: 661  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
            AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658  AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717

Query: 721  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
            LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718  LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777

Query: 781  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
            RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778  RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837

Query: 841  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
            LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 838  LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897

Query: 901  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
            VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 898  VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957

Query: 961  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1008
            LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS
Sbjct: 958  LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005


>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
          Length = 879

 Score = 1702 bits (4409), Expect = 0.0
 Identities = 860/863 (99%), Positives = 860/863 (99%), Gaps = 3/863 (0%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIK   ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117

Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
           HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177

Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
           TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237

Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
           RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297

Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
           PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357

Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
           LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417

Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
           LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477

Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
           YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537

Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
           TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597

Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
           DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657

Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
           AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717

Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
           LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777

Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
           RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837

Query: 841 LYISLHRYDEGNFFPGSGAPNEV 863
           LYISLHRYDEGNFFPGSGAPNEV
Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEV 860


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score = 1173 bits (3035), Expect = 0.0
 Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%)

Query: 1    MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
            +HS+  +V+VK  +P  +            SP++LR  L   +  VDP +RE+QLQQELL
Sbjct: 26   LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82

Query: 52   LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109
             ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L  +++Q+L
Sbjct: 83   ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142

Query: 110  EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164
            EQQRQ     ++E+E+ R EQQL  LR K++ +E A+ASTEVK +LQEFLLSKS  K+  
Sbjct: 143  EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200

Query: 165  TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221
              G NHS+ +HPK W   AHH SLDQSSPP SG   T PSYK  LPG  D++DDFPLRKT
Sbjct: 201  PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258

Query: 222  ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276
            ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR  E+T      SSV +S+PGS
Sbjct: 259  ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318

Query: 277  GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336
            GPSSPN+  +       T  +P  P   +M+ Q R L  + S N  SLYTSPSLPNI+LG
Sbjct: 319  GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376

Query: 337  LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389
            L A      S L AS  L  +Q+ E Q   +LRQG  L G++  +         V LEG 
Sbjct: 377  LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436

Query: 390  PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449
                 H +LLQH+LL EQ RQQ  L+A  VPLH QSPL T ER++  +R   KLPRHRPL
Sbjct: 437  GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494

Query: 450  NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507
            +RTQS+PLPQS   L QLV+QQQHQQFLEKQKQ  QQ+ + K+L+K+ E  +QP +H EE
Sbjct: 495  SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552

Query: 508  AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557
             EEEL        G+ A+   R  S+   ST+ D       DD   +   ++VK+E  +S
Sbjct: 553  TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612

Query: 558  --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
              +E   ++E  +G +  F     L+P     L V QAPL+   +     H+ + RT SS
Sbjct: 613  GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663

Query: 616  PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
            PAA        D+P++    TG+ YD  MLKHQC+CGN+  HPEHAGRIQSIWSRLQETG
Sbjct: 664  PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723

Query: 676  LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735
            LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG  SQK ++ LPCG
Sbjct: 724  LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783

Query: 736  GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795
            G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 784  GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843

Query: 796  CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855
            CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 844  CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903

Query: 856  GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915
            GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 904  GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963

Query: 916  FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975
            FDA+EGH  PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 964  FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023

Query: 976  LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033
            L  EL+PL E +L Q PN+NAV +L+K+IEIQSK+W  V+  A   G +L  AQ    EE
Sbjct: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083

Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069
             ETVSA+A L+V  EQ  A    +   R A EPME+EPAL
Sbjct: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score = 1173 bits (3035), Expect = 0.0
 Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%)

Query: 1    MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
            +HS+  +V+VK  +P  +            SP++LR  L   +  VDP +RE+QLQQELL
Sbjct: 25   LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81

Query: 52   LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109
             ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L  +++Q+L
Sbjct: 82   ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141

Query: 110  EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164
            EQQRQ     ++E+E+ R EQQL  LR K++ +E A+ASTEVK +LQEFLLSKS  K+  
Sbjct: 142  EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199

Query: 165  TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221
              G NHS+ +HPK W   AHH SLDQSSPP SG   T PSYK  LPG  D++DDFPLRKT
Sbjct: 200  PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257

Query: 222  ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276
            ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR  E+T      SSV +S+PGS
Sbjct: 258  ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317

Query: 277  GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336
            GPSSPN+  +       T  +P  P   +M+ Q R L  + S N  SLYTSPSLPNI+LG
Sbjct: 318  GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375

Query: 337  LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389
            L A      S L AS  L  +Q+ E Q   +LRQG  L G++  +         V LEG 
Sbjct: 376  LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435

Query: 390  PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449
                 H +LLQH+LL EQ RQQ  L+A  VPLH QSPL T ER++  +R   KLPRHRPL
Sbjct: 436  GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493

Query: 450  NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507
            +RTQS+PLPQS   L QLV+QQQHQQFLEKQKQ  QQ+ + K+L+K+ E  +QP +H EE
Sbjct: 494  SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551

Query: 508  AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557
             EEEL        G+ A+   R  S+   ST+ D       DD   +   ++VK+E  +S
Sbjct: 552  TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611

Query: 558  --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
              +E   ++E  +G +  F     L+P     L V QAPL+   +     H+ + RT SS
Sbjct: 612  GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662

Query: 616  PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
            PAA        D+P++    TG+ YD  MLKHQC+CGN+  HPEHAGRIQSIWSRLQETG
Sbjct: 663  PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722

Query: 676  LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735
            LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG  SQK ++ LPCG
Sbjct: 723  LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782

Query: 736  GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795
            G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 783  GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842

Query: 796  CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855
            CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 843  CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902

Query: 856  GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915
            GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 903  GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 962

Query: 916  FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975
            FDA+EGH  PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 963  FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1022

Query: 976  LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033
            L  EL+PL E +L Q PN+NAV +L+K+IEIQSK+W  V+  A   G +L  AQ    EE
Sbjct: 1023 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1082

Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069
             ETVSA+A L+V  EQ  A    +   R A EPME+EPAL
Sbjct: 1083 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score = 1143 bits (2956), Expect = 0.0
 Identities = 629/1093 (57%), Positives = 781/1093 (71%), Gaps = 57/1093 (5%)

Query: 1    MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
            ++ M S+VDV + +P+ + P + P+DLR D +  +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 25   VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84

Query: 60   QKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVE 119
            Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK QQE+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 85   QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144

Query: 120  RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 179
            +  REQ+L  L+ K++G+E AVASTEVK KLQEF+L+K   K       NH +S  P+ W
Sbjct: 145  KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202

Query: 180  YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 239
            Y    H+SLDQSSPP SG S SY + + G  DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 203  YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262

Query: 240  RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 299
            RRSSPLLRRKDG VVT+ KKR  +VT+S+ SS+ PGSGPSSPNN       EN  +   P
Sbjct: 263  RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321

Query: 300  TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 359
            +  AE  ++  R++  E S   L LYTSPSLPNITLGLPA       +   ++ ++    
Sbjct: 322  SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379

Query: 360  TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 417
             L+Q + L PG +    P  S+ P   LE +   ++H  LLQH++L EQ   Q  LV G 
Sbjct: 380  ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433

Query: 418  -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 474
              +PLH QS L   +R+SP I   HKL +HRPL RTQSAPLPQ+   L  LVIQQQHQQF
Sbjct: 434  GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489

Query: 475  LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 528
            LEK KQ   QQQ+ MNK++ K  E  +QP SH EE EEEL+  QA+ +    DR P    
Sbjct: 490  LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547

Query: 529  STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 580
                       +   Q G V+VK+EP++SDE+           Q   S ++  F QQ  L
Sbjct: 548  ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596

Query: 581  -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 638
             E      L   QA + A G+      HR +SR  SSPA++  P    + P +P   TG+
Sbjct: 597  LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656

Query: 639  AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 698
             YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL  KCE I+GRKA+LEE+Q VHS
Sbjct: 657  VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716

Query: 699  EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 758
            E H+LLYGTNPL+ QKLD + LLG  +  F   LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 717  EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775

Query: 759  GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 818
            GCV+EL  KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 776  GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835

Query: 819  IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 878
            IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 836  IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895

Query: 879  GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 938
            GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH  PLGGY ++A+CFG+
Sbjct: 896  GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955

Query: 939  LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 998
            LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV 
Sbjct: 956  LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015

Query: 999  SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1056
            S++K++EI SKYW+ ++      G +L  AQ    EE ETV+A+ASL+V V+      + 
Sbjct: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071

Query: 1057 RTAGEPMEEEPAL 1069
            R   EPMEEEP L
Sbjct: 1072 RPDEEPMEEEPPL 1084


>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
          Length = 590

 Score = 1121 bits (2899), Expect = 0.0
 Identities = 574/577 (99%), Positives = 574/577 (99%), Gaps = 3/577 (0%)

Query: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
           MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1   MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60

Query: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
           KQLLIAEFQKQHENLTRQHQAQLQEHIK   ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61  KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117

Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
           HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177

Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
           TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237

Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
           RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297

Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
           PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357

Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
           LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417

Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
           LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477

Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
           YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537

Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 577
           TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score =  674 bits (1738), Expect = 0.0
 Identities = 450/1018 (44%), Positives = 568/1018 (55%), Gaps = 123/1018 (12%)

Query: 83   LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
            LQ   +L   L     QQ+   +  +L       E++   +EQ+L  L  KD+ +  AVA
Sbjct: 61   LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 143  STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199
            S+ VKQKL E +L K      +    N           L    A  + L    PP+    
Sbjct: 121  SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177

Query: 200  PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259
                 +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +   S ++
Sbjct: 178  -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227

Query: 260  RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQRILIHE 316
            R  E     S  SSS+P SG SSPN+   G           P P    + +  QR+ + E
Sbjct: 228  RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQRLRLQE 276

Query: 317  DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP---------L 367
             S+   +L T   LP ITLGLPA P++ ++              L  G P         L
Sbjct: 277  TSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLFLPHGL 333

Query: 368  PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPL 427
              + GG++P S   P + L+   P+ SH  LL    L            G +P H    L
Sbjct: 334  EPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSL 377

Query: 428  ATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHM 487
             T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q    
Sbjct: 378  MTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ---- 425

Query: 488  NKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGA 547
              ++ +S +  ++P      + E+L+ D                      VDD L     
Sbjct: 426  --VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH--- 465

Query: 548  VKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHR 607
               +E      E      ++   Q    +Q  L     R  S     L  +   G   HR
Sbjct: 466  ---RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HR 518

Query: 608  LVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNST 655
             +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++
Sbjct: 519  PLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNS 578

Query: 656  THPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKL 715
             HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KL
Sbjct: 579  RHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKL 638

Query: 716  DPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKN 775
            D   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKN
Sbjct: 639  DNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKN 698

Query: 776  GFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFY 835
            GFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY
Sbjct: 699  GFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFY 758

Query: 836  ADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFR 895
             DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR
Sbjct: 759  QDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFR 818

Query: 896  TIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLAL 955
             +V P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLAL
Sbjct: 819  IVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLAL 878

Query: 956  EGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVR 1015
            EGGHDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKYW  ++
Sbjct: 879  EGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 938

Query: 1016 MVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067
             +A      VPR   + GA  +EE E V+ALASL+V +      ED  +     EEEP
Sbjct: 939  RLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 988


>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
          Length = 954

 Score =  652 bits (1683), Expect = 0.0
 Identities = 440/1010 (43%), Positives = 549/1010 (54%), Gaps = 144/1010 (14%)

Query: 83   LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
            LQ   +L   L     QQ+   +  +L       E++   +EQ+L  L  KD+ +  AVA
Sbjct: 61   LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 143  STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199
            S+ VKQKL E +L K      +    N           L    A  + L    PP+    
Sbjct: 121  SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177

Query: 200  PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259
                 +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +   S ++
Sbjct: 178  -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227

Query: 260  RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHED 317
            R  E     S  SSS+P SG SSPN+   G           P P         R      
Sbjct: 228  RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR------ 270

Query: 318  SMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSI 375
                    T P+L      LG P  P  L                      L  + GG++
Sbjct: 271  -------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPEAGGTL 304

Query: 376  PASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISP 435
            P S   P + L+   P+ SH  LL    L            G +P H    L T ER+S 
Sbjct: 305  P-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTTERLSG 348

Query: 436  GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 495
                      H PL+RT+S PLP S  A        Q  LE+ K + Q      ++ +S 
Sbjct: 349  S-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------VIKRSA 394

Query: 496  EQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPV 555
            +  ++P      + E+L+ D                      VDD L        +E   
Sbjct: 395  KPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------RELGH 433

Query: 556  DSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
               E      ++   Q    +Q  L     R  S     L  +   G   HR +SR  SS
Sbjct: 434  GQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLSRAQSS 489

Query: 616  PAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHPEHAGR 663
            PAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HPEHAGR
Sbjct: 490  PAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGR 549

Query: 664  IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 723
            IQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD   L G 
Sbjct: 550  IQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGL 609

Query: 724  DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 783
             +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFAVVRPP
Sbjct: 610  LAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPP 669

Query: 784  GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 843
            GHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DPS+LYI
Sbjct: 670  GHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYI 729

Query: 844  SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903
            SLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V P+A+
Sbjct: 730  SLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 789

Query: 904  EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 963
            EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLALEGGHDLTA
Sbjct: 790  EFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTA 849

Query: 964  ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA----- 1018
            ICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKYW  ++ +A     
Sbjct: 850  ICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDS 909

Query: 1019 -VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067
             VPR   + GA  +EE E V+ALASL+V +      ED  +     EEEP
Sbjct: 910  WVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951


>gi|13128864 histone deacetylase 6 [Homo sapiens]
          Length = 1215

 Score =  282 bits (722), Expect = 1e-75
 Identities = 169/408 (41%), Positives = 234/408 (57%), Gaps = 39/408 (9%)

Query: 616  PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
            P   +L  P +       S TG+ YD  M+ H C   +S  HPE   RI  I  RL+E G
Sbjct: 467  PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518

Query: 676  LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 734
            L  +C  +  R A+  E+   HS E+   L  T  +  ++L        +S  F S   C
Sbjct: 519  LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572

Query: 735  GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 794
                           +   A++A G    L   V SGE+ NG AVVRPPGHHAE+  A G
Sbjct: 573  PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619

Query: 795  FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 853
            FCFFNSVA+ A++ +    +  +ILIVD DVHHGNGTQ  F  DPS+LY+SLHRYD G F
Sbjct: 620  FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679

Query: 854  FP--GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVL 911
            FP    GA +++G   G G+ +N+AW G   P MGD +YL A+  +V P+A EF+P++VL
Sbjct: 680  FPMGDEGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVL 736

Query: 912  VSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEAC 971
            VSAGFDA  G   PLGG +V+ + + HLT  LM LA GR++L LEGG++LT+I ++  AC
Sbjct: 737  VSAGFDAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAAC 794

Query: 972  VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAV 1019
              +LLG   +P     L + P   A+ S+ + I++  +YW+S+R++ V
Sbjct: 795  TRSLLG---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV 839



 Score =  236 bits (603), Expect = 7e-62
 Identities = 143/382 (37%), Positives = 212/382 (55%), Gaps = 32/382 (8%)

Query: 634  SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 693
            + TG+  D  + +  C+  +S   PE   R+ +I  +L + GLL++C   Q R A  EE+
Sbjct: 84   AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141

Query: 694  QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 752
             LVHS E+  L+  T  ++  +L  R+L                     D+++   +S  
Sbjct: 142  MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182

Query: 753  AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 812
             A +A G V+ L   V   E++NG A++RPPGHHA+ S   G+C FN VA+ A+Y + + 
Sbjct: 183  CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242

Query: 813  NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEG 870
             I ++LIVD DVHHG GTQ  F  DPS+LY S+HRY++G F+P   A N    G G G+G
Sbjct: 243  RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQG 302

Query: 871  YNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYK 930
            Y IN+ W       M D +Y+ AF  ++ PVA EF P +VLV+AGFDAL+G   P G   
Sbjct: 303  YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMA 357

Query: 931  VTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQ 990
             T   F  LT  LM LA G+++L+LEGG++L A+ +   A ++ LLG+   P+ E     
Sbjct: 358  ATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPC-PMLES--PG 414

Query: 991  SPNMNAVISLQKIIEIQSKYWK 1012
            +P  +A  S+   +E    +W+
Sbjct: 415  APCRSAQASVSCALEALEPFWE 436


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score =  236 bits (601), Expect = 1e-61
 Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%)

Query: 636  TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695
            T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 696  VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754
            VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 63   VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103

Query: 755  RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814
            R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163

Query: 815  SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872
             +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P       + VG G G G+ 
Sbjct: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223

Query: 873  INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932
            +N+ W       MG+ +Y+ AF  ++ P+A EFDP++VLVSAGFD+  G   P G  + T
Sbjct: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278

Query: 933  AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992
             +CF HLT+ L  LA GRV   LEGG+ L ++ ++    V  LLG+   PL+  +   +P
Sbjct: 279  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335

Query: 993  NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020
              +A+ S+Q     Q+ +WKS++   + AVP
Sbjct: 336  CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366


>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score =  202 bits (514), Expect = 1e-51
 Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%)

Query: 636  TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695
            T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 696  VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754
            VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 63   VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103

Query: 755  RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814
            R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163

Query: 815  SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872
             +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P       + VG G G G+ 
Sbjct: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223

Query: 873  INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932
            +N+ W       MG+ +Y+ AF  ++ P+A E                      G  + T
Sbjct: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258

Query: 933  AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992
             +CF HLT+ L  LA GRV   LEGG+ L ++ ++    V  LLG+   PL+  +   +P
Sbjct: 259  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315

Query: 993  NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020
              +A+ S+Q     Q+ +WKS++   + AVP
Sbjct: 316  CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346


>gi|116284376 histone deacetylase 2 [Homo sapiens]
          Length = 582

 Score =  111 bits (278), Expect = 3e-24
 Identities = 105/384 (27%), Positives = 168/384 (43%), Gaps = 61/384 (15%)

Query: 657  HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 712
            HP    RI+   + L   GL  K E  +  KA+ EE+   HS+ +      +   N  + 
Sbjct: 123  HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182

Query: 713  QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
             K   R  +G+D   F     F  L  GG  V      N   +  A   A G        
Sbjct: 183  SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234

Query: 768  VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 827
                             HHA++S A GFC+ N + +    L       ++L +D+D+HHG
Sbjct: 235  -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275

Query: 828  NGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGD 887
            +G ++AFY    ++ +S H+Y  G +FPG+G   ++G G G+ Y +N     G+D    D
Sbjct: 276  DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329

Query: 888  VEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLA 947
              Y + F+ I+  V + + P  V++  G D+L G    LG + +T K  GH  K +  + 
Sbjct: 330  ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVVK 384

Query: 948  DGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP-N 993
               + L + GG   T    A C   E  V  +  + NEL      E    D  LH SP N
Sbjct: 385  TFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN 444

Query: 994  MNAVISLQKIIEIQSKYWKSVRMV 1017
            M    + + + +I+ + ++++RM+
Sbjct: 445  MTNQNTPEYMEKIKQRLFENLRML 468


>gi|13128860 histone deacetylase 1 [Homo sapiens]
          Length = 482

 Score =  110 bits (275), Expect = 7e-24
 Identities = 105/385 (27%), Positives = 170/385 (44%), Gaps = 63/385 (16%)

Query: 657  HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 712
            HP    RI+   + L   GL  K E  +  KA+ EE+   HS+ +     +    N  + 
Sbjct: 28   HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87

Query: 713  QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
             K   R  +G+D   F     F  L  GG                           +AS 
Sbjct: 88   SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121

Query: 768  VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 826
            V   + +   AV    G HHA++S A GFC+ N + +    L       ++L +D+D+HH
Sbjct: 122  VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179

Query: 827  GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 886
            G+G ++AFY    ++ +S H+Y  G +FPG+G   ++G G G+ Y +N     G+D    
Sbjct: 180  GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID---- 233

Query: 887  DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 946
            D  Y   F+ ++  V + F P  V++  G D+L G    LG + +T K  GH  K +  +
Sbjct: 234  DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR--LGCFNLTIK--GH-AKCVEFV 288

Query: 947  ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 992
                + + + GG   T    A C   E  V  +  + NEL      E    D  LH SP 
Sbjct: 289  KSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPS 348

Query: 993  NMNAVISLQKIIEIQSKYWKSVRMV 1017
            NM    + + + +I+ + ++++RM+
Sbjct: 349  NMTNQNTNEYLEKIKQRLFENLRML 373


>gi|8923769 histone deacetylase 8 [Homo sapiens]
          Length = 377

 Score =  107 bits (268), Expect = 5e-23
 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%)

Query: 626 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 682
           M+ P +P  + G +  P+ +   ++  +C +    P+ A  + S+   ++   L  +   
Sbjct: 1   MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56

Query: 683 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 740
           ++ + AS+EE+   H++ +           Q L      GDD           GLG D  
Sbjct: 57  VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103

Query: 741 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 798
            ++ I++   + G A + A  C+I+   KVA      G+       HHA++  A GFC+ 
Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155

Query: 799 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 858
           N   +    LR +    +IL VDLD+HHG+G + AF     ++ +SLH++  G FFPG+G
Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212

Query: 859 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 918
             ++VG G G  Y++N+    G+     D +Y +   +++K V + F+P  V++  G D 
Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268

Query: 919 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 978
           + G   P+  + +T    G   K ++      ++L   GG++L             +LG 
Sbjct: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325

Query: 979 EL 980
            L
Sbjct: 326 TL 327


>gi|13128862 histone deacetylase 3 [Homo sapiens]
          Length = 428

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 47/136 (34%), Positives = 74/136 (54%), Gaps = 9/136 (6%)

Query: 785 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 844
           HHA++  A GFC+ N + I    L       ++L +D+D+HHG+G Q+AFY    ++ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191

Query: 845 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903
            H+Y  GN FFPG+G   EVG   G  Y +N+    G+D    D  Y   F+ ++  V  
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245

Query: 904 EFDPDMVLVSAGFDAL 919
            + P  +++  G D+L
Sbjct: 246 FYQPTCIVLQCGADSL 261


>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
          Length = 347

 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)

Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 709
           G    HP  AG+   + + L+E  LL+    ++ R+AS E++ +VH+  +   L +    
Sbjct: 30  GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89

Query: 710 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
               ++ P I L +    +K    L                      R   G  I +A K
Sbjct: 90  ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126

Query: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 825
           +A   ++ G+A+    G HH       GFC +  + +  K+L +++  IS+  I+DLD H
Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183

Query: 826 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 885
            GNG ++ F  D  +  + ++     + +PG     +          + + W  G +   
Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230

Query: 886 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 945
            D EYL+     +K   +E  PD+V+ +AG D LEG    LGG  ++        + +  
Sbjct: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287

Query: 946 LADGR---VVLALEGGH 959
           +  GR   +++   GG+
Sbjct: 288 MVRGRRVPILMVTSGGY 304


>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
          Length = 296

 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)

Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 711
           G    HP  AG+   + + L+E  LL+    ++ R+AS E++ +VH+  +      N L 
Sbjct: 2   GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56

Query: 712 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 771
            + L P                                     R   G  I +A K+A  
Sbjct: 57  RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77

Query: 772 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 829
            ++ G+A+    G HH       GFC +  + +  K+L +++  IS+  I+DLD H GNG
Sbjct: 78  -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136

Query: 830 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 889
            ++ F  D  +  + ++     + +PG     +          + + W  G +    D E
Sbjct: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182

Query: 890 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 949
           YL+     +K   +E  PD+V+ +AG D LEG    LGG  ++        + +  +  G
Sbjct: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240

Query: 950 R---VVLALEGGH 959
           R   +++   GG+
Sbjct: 241 RRVPILMVTSGGY 253


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 44/114 (38%), Positives = 68/114 (59%), Gaps = 7/114 (6%)

Query: 45  QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ-ELLAIKQQQELL 103
           Q QQ+LLL+QQQ Q+Q+QLL  +  +  + L  Q QAQLQ+ + LQQ E L  +QQQ+LL
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295

Query: 104 EKEQKLEQQRQ------EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151
           +++Q+  QQ+Q      E E E     + +P   G ++  E+     E +Q+L+
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELE 349



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 38/93 (40%), Positives = 65/93 (69%), Gaps = 7/93 (7%)

Query: 42  REKQLQQELLLIQQQQ-QIQKQLLIAEFQKQ-HENLTRQHQAQLQEHIKLQQELLAIKQQ 99
           +++QLQQ+    QQ+Q Q Q+QLL+ + Q Q  + L +Q QAQLQ+ +  QQ+  A  QQ
Sbjct: 219 QQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQ--AQLQQ 276

Query: 100 QELLEKEQKLEQQRQEQEVERHR---REQQLPP 129
           Q LL+++++L+QQ+Q+Q +++ +   ++QQL P
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQP 309



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 40/100 (40%), Positives = 65/100 (65%), Gaps = 15/100 (15%)

Query: 43  EKQLQQELLLIQQQQQIQKQLLIAE--------FQKQHENLTRQHQ-AQLQEHIKLQQEL 93
           ++Q+Q++ LL QQQ+Q+Q+Q L+ +        FQ+Q E L +Q Q   LQ+  +LQQ+L
Sbjct: 195 QQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQL 254

Query: 94  LAIKQ---QQELLEKEQKLEQQR---QEQEVERHRREQQL 127
           L  +Q   QQ+LLE++Q   QQ+   Q+QE  + +++QQL
Sbjct: 255 LQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQL 294



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 42/102 (41%), Positives = 64/102 (62%), Gaps = 18/102 (17%)

Query: 42  REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKLQQELLAIK 97
           ++ QLQQ+LL  QQQ Q+Q+QLL+ +     Q+Q + L +Q Q QLQ+  +LQ   L  +
Sbjct: 258 QQAQLQQQLLE-QQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQ-QLQPPPLEPE 315

Query: 98  QQQEL--------LEKEQKLEQQRQE----QEVERHRREQQL 127
           +++E+        L  EQ+LEQQRQE    QE+ER + ++QL
Sbjct: 316 EEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%)

Query: 338 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 393
           PAV + + AS   +E    +++ + Q L Q  P P Q           PH+ L+ +P   
Sbjct: 67  PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125

Query: 394 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453
             Q L Q   L+++  Q          +H Q        + P ++  H+  + +P    +
Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166

Query: 454 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513
              L Q        Q Q QQ L++Q+Q QQQ+   +LL +  EQL+Q    L + +E+LQ
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224

Query: 514 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 573
             Q  Q+          +      +    GQ+      ++ +   + AQ+Q+    +Q A
Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272

Query: 574 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 608
            +QQ  L     +    +Q  L     + L++ +L
Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 37/128 (28%), Positives = 80/128 (62%), Gaps = 7/128 (5%)

Query: 33  MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQE 92
           + P +  + +++QLQ +   +Q+QQ++Q+Q    + Q+  E    Q Q QLQ+ ++ QQ 
Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203

Query: 93  LLAIK---QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149
           L   +   QQQ+LL+++++L+QQ+ +Q+ E+ +++QQL  L+ + + +++ +   + +  
Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQ-- 261

Query: 150 LQEFLLSK 157
           LQ+ LL +
Sbjct: 262 LQQQLLEQ 269



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 36/117 (30%), Positives = 69/117 (58%), Gaps = 10/117 (8%)

Query: 41  VREKQLQQELLLIQQ---QQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIK 97
           ++ +Q Q++ +L QQ   QQQ+Q+Q L+   Q+Q E L +Q   Q QE ++ QQ     +
Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLL---QQQQEQLQQQQLLQQQEQLQQQQ----FQ 229

Query: 98  QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154
           QQQE L+++Q+L   +Q+ ++++   +QQ   L+ +   +++A    ++  + QE L
Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 30/132 (22%)

Query: 44  KQLQQELLLIQQQQQIQKQLLIA------------------------EFQKQHENLTRQH 79
           +Q QQ+ LL QQQ+Q+Q+Q L                          E ++Q + L RQ 
Sbjct: 287 QQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346

Query: 80  QAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139
           + + Q+    +Q  L +K Q+EL + EQ+LEQQ  +Q++E+   + +L P+    + +E 
Sbjct: 347 ELERQQ----EQRQLQLKLQEELQQLEQQLEQQ--QQQLEQQEVQLELTPVELGAQQQEV 400

Query: 140 AVASTEVKQKLQ 151
            +  T V+ +LQ
Sbjct: 401 QLELTPVQPELQ 412



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 12/109 (11%)

Query: 47  QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLE 104
           QQ+L  +QQ+  Q +  Q L  E Q  H+    Q Q Q+QE  +LQQ       QQE L+
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQ-QVQEQQRLQQ-------QQEQLQ 178

Query: 105 KEQKLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151
            +Q  EQQ  +Q++++++  +EQQL   + +   +++ +   E  Q+ Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 20/111 (18%)

Query: 35  PVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQ-HENLTRQ--------------- 78
           P   P   + Q  Q  L +QQQ Q   Q  +++ Q++ H+++  Q               
Sbjct: 100 PQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQL 159

Query: 79  --HQAQLQEHIKLQQELLAIK--QQQELLEKEQKLEQQRQEQEVERHRREQ 125
              Q Q Q+ ++ QQE L  +  Q+Q++L+++++L+QQ QEQ++ + ++EQ
Sbjct: 160 QPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQ 210



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 38/132 (28%), Positives = 69/132 (52%), Gaps = 20/132 (15%)

Query: 39  PVVREKQLQQELLLIQQQQQIQKQLLIA-----EFQKQHENLTRQHQAQLQE-------H 86
           P  RE QLQQ     + QQQ Q + L       E Q+Q +   +Q  +QLQ+       H
Sbjct: 84  PGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHH 143

Query: 87  IKLQQELLAIKQQQEL----LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
            +L+ EL  + QQQ+L    ++++Q+L+QQ+++ + ++ + +Q L     +    ++ V 
Sbjct: 144 QELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQ----QQEQLQQQVQ 199

Query: 143 STEVKQKLQEFL 154
             ++ Q+ QE L
Sbjct: 200 EQQLLQQQQEQL 211



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%)

Query: 396 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453
           Q  LQ  LL++Q  Q  Q+LL      L  Q  L  +E++    +      +   L + Q
Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306

Query: 454 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499
             P P     +  ++              +Q +Q LE+Q++ ++Q    +L  K  E+L+
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366

Query: 500 QPGSHLEEAEEELQGDQAMQE 520
           Q    LE+ +++L+  +   E
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%)

Query: 396 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 447
           Q LLQ    +EQ++QQ+L      PL P+     +  + P   G+ +        L R +
Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346

Query: 448 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 506
            L R Q     +    QL +Q++ QQ  ++ +Q QQQ+   ++ L  +  +L   G+  +
Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398

Query: 507 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 552
           E + EL   Q  +Q +  P++G    +   A     +   G V V+E
Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445



 Score = 30.4 bits (67), Expect = 9.3
 Identities = 32/115 (27%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 15  PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74
           P  LEP    ++  +L   MPV   +  E++L+Q+   +++QQ++++Q    + Q + + 
Sbjct: 309 PPPLEPEEEEEVELEL---MPV--DLGSEQELEQQRQELERQQELERQQEQRQLQLKLQE 363

Query: 75  LTRQHQAQL--QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQL 127
             +Q + QL  Q+    QQE+     Q EL   E   +QQ  + E+   + E QL
Sbjct: 364 ELQQLEQQLEQQQQQLEQQEV-----QLELTPVELGAQQQEVQLELTPVQPELQL 413


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 63/373 (16%)

Query: 34  MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87
           M VV     + QLQ + + +QQQQQ Q      +FQ+Q +   +Q Q Q Q      +  
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194

Query: 88  KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
            +QQ+  A+ QQQ+ L+++Q       KL  Q Q+Q  ++ ++ Q++  L+ + + +++ 
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254

Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199
               + +Q LQ     +      P    + ++ +  +  +   HH    Q   PP++   
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314

Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255
           PS       T P    A+   P +   ++P LK   R    V +    P ++++   V T
Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372

Query: 256 SFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVS 308
           +   +M     +V++SS   +SS SPG    +P +             +PP P       
Sbjct: 373 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS-------------MPPPPQPSPQPG 419

Query: 309 QQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ--GVP 366
           Q                +S    N++ G    PS    S S +  Q   T    Q   VP
Sbjct: 420 QP---------------SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVP 464

Query: 367 LPGQYGGSIPASS 379
            PG     +  SS
Sbjct: 465 SPGPLNTPVNPSS 477



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 85/436 (19%), Positives = 157/436 (36%), Gaps = 76/436 (17%)

Query: 84  QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAS 143
           Q  ++LQQ  L  +QQQ+  +++Q+   Q+Q+Q+ ++ + + Q   ++ + +   +    
Sbjct: 150 QTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQ 209

Query: 144 TEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYK 203
            + +Q+ Q+ L+            +   + R  +L         L Q            +
Sbjct: 210 LQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQ 261

Query: 204 YTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFE 263
             L  AQ      P+++    P+  +  +L+Q    +   P                   
Sbjct: 262 QALQ-AQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQP------------------- 301

Query: 264 VTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLS 323
                         P  P   P   V +N+ S LPP    + +VSQ + L  +       
Sbjct: 302 --------------PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------M 338

Query: 324 LYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSH 381
           LYT P L  +    P V  Q      ++++Q          +  PG      S+P  SS 
Sbjct: 339 LYTQPPLKFVRA--PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS- 395

Query: 382 PHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISP 435
           P    + + P S            +   Q    V+ G    P S      P  ++  ++ 
Sbjct: 396 PSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTA 455

Query: 436 GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKS 494
                  +P   PLN   +   P S ++     Q + QQ+L+K KQ          LSK 
Sbjct: 456 RTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKY 502

Query: 495 IEQLKQPGSHLEEAEE 510
           IE L++  + +++ E+
Sbjct: 503 IEPLRRMINKIDKNED 518



 Score = 37.0 bits (84), Expect = 0.100
 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)

Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493
           GT  +  H     + + P  Q  L Q+ +QQQ QQ  F ++Q+   Q QQQ    +    
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191

Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553
               ++Q    + + +++LQ  Q  Q+        + +          L ++  ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249

Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613
                +  Q Q+     Q    Q P  +P        +  P  A+     + H   ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299

Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652
             P     P  A ++P  L P S T     PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 46/182 (25%), Positives = 91/182 (50%), Gaps = 4/182 (2%)

Query: 23  PLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQ 80
           PL +   + MM P V+ P   ++ LQQ++L  QQ Q + Q+Q  +   Q+Q +   ++ Q
Sbjct: 84  PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143

Query: 81  AQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
            QL   + LQQ+    +QQQ+  +++Q+ +QQ+Q+Q+ ++ +++QQ     GK    ++ 
Sbjct: 144 EQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQ 202

Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTS 199
               + +   Q+ +  +   +      + H +S +   L        +L   S P +G S
Sbjct: 203 QQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLS 262

Query: 200 PS 201
           P+
Sbjct: 263 PA 264



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)

Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486
           + T + I+P  +   ++ + + L+  Q   L Q   A ++ QQQ Q+F +KQ   Q+Q+H
Sbjct: 93  MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147

Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546
           +  L  +  +Q +Q     ++ +++ Q  Q  Q+ +             A       Q  
Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207

Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604
                ++ V   +  Q+Q+++  +    +Q+  L   P    AL V+  P A +    ++
Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267

Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
           +  + V+  HS     +  H  +D      S+T  +      P +  H  V G S+
Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 63/259 (24%), Positives = 114/259 (44%), Gaps = 21/259 (8%)

Query: 43  EKQLQQELLLIQQQQQ-----IQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKLQQELLAI 96
           E  L+++ L +QQ+ +     +++Q L+ E Q ++ E   RQ  A+ Q+ I+ Q+E    
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408

Query: 97  KQQQELLEKEQKLEQQRQE--QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154
            ++Q+  E+E + +Q+R++  +E E  RR ++L   R ++  R RA       ++ QE++
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468

Query: 155 LSKSATKDTPTNGKNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ 210
             +   +          + +   +    +   H     Q  PP    S PS+    P A 
Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAH 528

Query: 211 ----DAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVT 265
               D   + P+R T+  P L  R    Q   ++ S    R    N  +S + R ++E  
Sbjct: 529 YEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERV 584

Query: 266 ESSVSSSSPGSGPSSPNNG 284
           E  V     GS   S N+G
Sbjct: 585 EKLVPRPGSGSSSGSSNSG 603


>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
          Length = 788

 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 108/497 (21%), Positives = 192/497 (38%), Gaps = 99/497 (19%)

Query: 34  MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87
           M VV     + QLQ + + +QQQQQ Q      +FQ+Q +   +Q Q Q Q      +  
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194

Query: 88  KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
            +QQ+  A+ QQQ+ L+++Q       KL  Q Q+Q  ++ ++ Q++  L+ + + +++ 
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254

Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199
               + +Q LQ     +      P    + ++ +  +  +   HH    Q   PP++   
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314

Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255
           PS       T P    A+   P +   ++P LK   R    V +    P ++++   V T
Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372

Query: 256 SFKKRMFEVTESSVSSS-SPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILI 314
           +   +M       ++ + + G         PT +V+   +S +P        VSQ     
Sbjct: 373 AQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQS---- 428

Query: 315 HEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGS 374
                         SLP   L  P+   Q+    S+            Q  P PGQ    
Sbjct: 429 --------------SLP--MLSSPSPGQQVQTPQSMPPPP--------QPSPQPGQ---- 460

Query: 375 IPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERIS 434
            P+S  + +V+    P  SS                          L   SP  ++  ++
Sbjct: 461 -PSSQPNSNVSSGPAPSPSSF-------------------------LPSPSPQPSQSPVT 494

Query: 435 PGIRGTHKLPRHRPLNRTQSAPLPQSTLAQL-VIQQQHQQFLEKQKQYQQQIHMNKLLSK 493
                   +P   PLN   +   P S ++     Q + QQ+L+K KQ          LSK
Sbjct: 495 ARTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSK 541

Query: 494 SIEQLKQPGSHLEEAEE 510
            IE L++  + +++ E+
Sbjct: 542 YIEPLRRMINKIDKNED 558



 Score = 37.0 bits (84), Expect = 0.100
 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)

Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493
           GT  +  H     + + P  Q  L Q+ +QQQ QQ  F ++Q+   Q QQQ    +    
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191

Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553
               ++Q    + + +++LQ  Q  Q+        + +          L ++  ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249

Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613
                +  Q Q+     Q    Q P  +P        +  P  A+     + H   ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299

Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652
             P     P  A ++P  L P S T     PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 46/168 (27%), Positives = 81/168 (48%), Gaps = 7/168 (4%)

Query: 42   REKQLQQELLLIQQQQQ-IQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQ 100
            +++QLQQ+  L QQQQQ +Q+Q  + + Q Q +   +Q Q Q Q+ ++ QQ+ L  +QQQ
Sbjct: 3902 QQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQ 3961

Query: 101  ELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT 160
            +    +Q+ +QQ+Q+Q++    + + L  L  + + +++      +  K  +   S  A 
Sbjct: 3962 Q----QQQFQQQQQQQQMGLLNQSRTL--LSPQQQQQQQVALGPGMPAKPLQHFSSPGAL 4015

Query: 161  KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 208
              T         +  P +   A    S  Q  P   GT+P    T PG
Sbjct: 4016 GPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 139/663 (20%), Positives = 236/663 (35%), Gaps = 140/663 (21%)

Query: 43   EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQE 101
            E   ++  L+ +QQ +IQKQL  + + QK+H NL  +++                KQQQ+
Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN---------------KQQQQ 3602

Query: 102  LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATK 161
                +Q+ +QQ+Q+          Q P L  K  G+       +  Q            +
Sbjct: 3603 ----QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLR 3656

Query: 162  DTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKT 221
             TP           P L    A       S    S   PS  +  PG    +   P  + 
Sbjct: 3657 LTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRL 3715

Query: 222  ASEPNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG 277
              E  L++   R +L QK+ +++     ++   G V    +++     +++ +      G
Sbjct: 3716 LQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQG 3775

Query: 278  ---PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRIL 313
               PSS            P  GP G +   + +VL         P  PH + +++Q R+L
Sbjct: 3776 LMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL 3835

Query: 314  IHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGG 373
                        +SP L     GL  +  +L  +   +++Q+ + Q    G+    Q   
Sbjct: 3836 ------------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ--- 3878

Query: 374  SIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERI 433
            S+ + S  P   L  +P  S  Q   Q  L ++Q  QQ+           Q  L  ++++
Sbjct: 3879 SLMSHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL 3926

Query: 434  SPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSK 493
                               Q   L Q    Q + QQQ QQ  ++Q+Q QQQ    +   +
Sbjct: 3927 -------------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQ 3967

Query: 494  SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVK 549
              +Q +Q G  L ++   L   Q  Q+  A   G   +      S   +  TL   G  +
Sbjct: 3968 QQQQQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQ 4026

Query: 550  VKEEPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTH 584
               +P  S                          E  +++   SG+    + QP  +P  
Sbjct: 4027 NTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQP 4086

Query: 585  T--------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPG 633
            +        R    +Q  ++ +   G   H  +    SS A+SV   L  P++    QPG
Sbjct: 4087 SSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPG 4146

Query: 634  SAT 636
            S T
Sbjct: 4147 SMT 4149



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 105/460 (22%), Positives = 169/460 (36%), Gaps = 115/460 (25%)

Query: 54   QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQ------ 107
            QQQQQ Q+Q  +A      ++L   H  Q +   +    L  ++QQQ+L +++Q      
Sbjct: 3859 QQQQQHQQQGSMAGLSHLQQSLM-SHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQ 3917

Query: 108  ---KLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF----------L 154
               + +QQ Q+Q++++ +++QQL   + +   +++     + +Q+ Q+F          L
Sbjct: 3918 QQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGL 3977

Query: 155  LSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKD 214
            L++S T  +P   +   V+  P +                     P   ++ PGA     
Sbjct: 3978 LNQSRTLLSPQQQQQQQVALGPGM------------------PAKPLQHFSSPGALG--- 4016

Query: 215  DFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSP 274
                      P L                 LL  K+ N V           + +VSS + 
Sbjct: 4017 ----------PTL-----------------LLTGKEQNTV-----------DPAVSSEAT 4038

Query: 275  GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNIT 334
              GPS+   GP    T  E+    P      +    ++L       L+     P   ++ 
Sbjct: 4039 -EGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLL-------LVQPQPQPQPSSLQ 4090

Query: 335  LGLP-AVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYG-GSIPASSSHPHVTLE----- 387
            L  P  +P Q     SL             G    GQ G GS   +SS PH+  +     
Sbjct: 4091 LQPPLRLPGQQQQQVSLLH---------TAGGGSHGQLGSGSSSEASSVPHLLAQPSVSL 4141

Query: 388  GKPPNSSHQALL--QHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPR 445
            G  P S  Q LL  Q  +L+  M+       G  P  P   L + +    G+ G   +P 
Sbjct: 4142 GDQPGSMTQNLLGPQQPMLERPMQNN----TGPQPPKPGPVLQSGQ----GLPGVGIMPT 4193

Query: 446  HRPLN-RTQSAPLPQSTLAQLVIQQQHQ-QFLEKQKQYQQ 483
               L  + Q        L  L  QQQ Q Q L  Q+Q QQ
Sbjct: 4194 VGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQ 4233


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 45/185 (24%), Positives = 91/185 (49%), Gaps = 4/185 (2%)

Query: 20  PISPLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTR 77
           P +   +   + MM P V+ P   ++ LQQ++L  QQ Q + Q+Q  +   Q+Q +   +
Sbjct: 106 PHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYK 165

Query: 78  QHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 137
           + Q QL   + LQQ+    +QQQ+  +++Q+ +QQ+Q+Q+ ++ +++QQ     GK    
Sbjct: 166 KQQEQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKE 224

Query: 138 ERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLS 196
           ++     + +   Q+ +  +   +      + H +S +   L        +L   S P +
Sbjct: 225 QQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQA 284

Query: 197 GTSPS 201
           G SP+
Sbjct: 285 GLSPA 289



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 28/283 (9%)

Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAG--GVPLHPQSPLA--------TKERISPGIRG 439
           P +S  Q  LQ LL      + KL + G      HP +  A        T + I+P  + 
Sbjct: 76  PKSSDKQRPLQELL-----PETKLCICGHSSGDGHPHNTFAVPVSVAMMTPQVITP--QQ 128

Query: 440 THKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499
             ++ + + L+  Q   L Q   A ++ QQQ Q+F +KQ   Q+Q+H+  L  +  +Q +
Sbjct: 129 MQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLHLQLLQQQQQQQQQ 185

Query: 500 QPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDE 559
           Q     ++ +++ Q  Q  Q+ +             A       Q       ++ V   +
Sbjct: 186 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQ 245

Query: 560 DAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLEK-HRLVSRTHSSP 616
             Q+Q+++  +    +Q+  L   P    AL V+  P A +    +++  + V+  HS  
Sbjct: 246 LLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSME 305

Query: 617 AASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
              +  H  +D      S+T  +      P +  H  V G S+
Sbjct: 306 DNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 347


>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
          Length = 623

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 44/173 (25%), Positives = 87/173 (50%), Gaps = 4/173 (2%)

Query: 32  MMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQAQLQEHIKL 89
           MM P V+ P   ++ LQQ++L  QQ Q + Q+Q  +   Q+Q +   ++ Q QL   + L
Sbjct: 1   MMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQL-L 59

Query: 90  QQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149
           QQ+    +QQQ+  +++Q+ +QQ+Q+Q+ ++ +++QQ     GK    ++     + +  
Sbjct: 60  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA 119

Query: 150 LQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTSPS 201
            Q+ +  +   +      + H +S +   L        +L   S P +G SP+
Sbjct: 120 AQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPA 172



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)

Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486
           + T + I+P  +   ++ + + L+  Q   L Q   A ++ QQQ Q+F +KQ   Q+Q+H
Sbjct: 1   MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 55

Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546
           +  L  +  +Q +Q     ++ +++ Q  Q  Q+ +             A       Q  
Sbjct: 56  LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 115

Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604
                ++ V   +  Q+Q+++  +    +Q+  L   P    AL V+  P A +    ++
Sbjct: 116 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 175

Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
           +  + V+  HS     +  H  +D      S+T  +      P +  H  V G S+
Sbjct: 176 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 230


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 71/295 (24%), Positives = 121/295 (41%), Gaps = 58/295 (19%)

Query: 41  VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-----QAQLQEHIKLQQELLA 95
           +R +QL QE  L +Q++   K+ L+AE QK+ E    Q      Q + +   + QQE   
Sbjct: 370 LRRQQLLQEQQLREQEEY--KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQ 427

Query: 96  IKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLL 155
            +++QE   + ++LE++R+E+E  R   E++    R ++  R +        + LQ+ LL
Sbjct: 428 RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLL 487

Query: 156 SKSA--------------TKDTPTNGKNHSVSRH---PKLWYTAA-------------HH 185
            + A               +  P   +    S H   PK  Y  A             +H
Sbjct: 488 QEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH 547

Query: 186 TSLDQSS--------PPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKV 237
           +S +  S        PP+   S S+        +++   P  +  +EP + VR+  +  V
Sbjct: 548 SSPEAQSKQTGRVLEPPVPSRSESF-----SNGNSESVHPALQRPAEPQVPVRTTSRSPV 602

Query: 238 AERRSSPL-------LRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGPSSPNNG 284
             RR SPL        +    N  +S + R ++E  E  V     GS   S N+G
Sbjct: 603 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSG 657


>gi|41152097 DNA segment on chromosome X and Y (unique) 155
           expressed sequence isoform 1 [Homo sapiens]
          Length = 695

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 44/151 (29%), Positives = 80/151 (52%), Gaps = 23/151 (15%)

Query: 37  VDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ----- 91
           ++ + RE++ +++L   ++++Q Q+   +   QK+ E L  + Q QLQE IKL++     
Sbjct: 309 LEELERERKREEKL---RKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLL 365

Query: 92  ------------ELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139
                       ELL+  +  +L E+EQK E+ R +Q+ ER R ++    LR  +  +ER
Sbjct: 366 AQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQE--AELRRVEEEKER 423

Query: 140 AVASTEVKQKLQEFLLSKSATKDTPTNGKNH 170
           A+     +++L+E LLS   +K  P +   H
Sbjct: 424 ALGLQRKERELRERLLSILLSK-KPDDSHTH 453



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 22/105 (20%), Positives = 64/105 (60%), Gaps = 8/105 (7%)

Query: 55  QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI--KLQQELLAIKQQQELLEKEQKLEQQ 112
           +++Q+++Q L    Q++ E   R+ +A+ ++    + Q+EL  ++++++  EK +K EQ+
Sbjct: 269 KKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQK 328

Query: 113 RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 157
           ++++E+ R++++ +      K +  E+     ++K + ++ LL++
Sbjct: 329 QRDRELRRNQKKLE------KLQAEEQKQLQEKIKLEERKLLLAQ 367



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 24/68 (35%), Positives = 39/68 (57%), Gaps = 11/68 (16%)

Query: 95  AIKQQQELLEKEQKLEQQRQEQ-----EVE-----RHRREQQLPPLRGKDRGRERAVAST 144
           +IK++Q   +K Q+LEQQR+EQ     E E       R++++L  L  ++R RE  +   
Sbjct: 267 SIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELE-RERKREEKLRKR 325

Query: 145 EVKQKLQE 152
           E KQ+ +E
Sbjct: 326 EQKQRDRE 333


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 112/559 (20%), Positives = 207/559 (37%), Gaps = 93/559 (16%)

Query: 34   MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQEL 93
            MP V P   +  L       QQQQQ Q+Q    + Q+Q +   +Q Q Q Q  I  QQ+ 
Sbjct: 571  MPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQ- 629

Query: 94   LAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK---L 150
               +QQQ  +  +Q+ +QQ+Q+Q+ ++ +++QQ    +       +++ S  + +    L
Sbjct: 630  ---QQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPL 686

Query: 151  QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSP-SYKYTLPGA 209
            Q+ LL +   ++ P  G  + VS+  +       H+ + Q++ P    +P S   T  G 
Sbjct: 687  QQKLLLQQ-MQNQPIAGMGYQVSQQQR----QDQHSVVGQNTGPSPSPNPCSNPNTGSGY 741

Query: 210  QDAKDDFPLRKTASEPNLKVRSRLKQKV-----------AER------------RSSPLL 246
             +++     ++   +     R  ++QK            AE+            R  P  
Sbjct: 742  MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY 801

Query: 247  RRKDGNVVTSFKKRMFEVTESSVSSSS-----------------------------PGSG 277
            + +  NV        +    S++S +S                             P   
Sbjct: 802  KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS 861

Query: 278  PSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPN-ITLG 336
             +  N G  G++  N+ +    T    Q+  Q+      +   LL+   +P +P   TLG
Sbjct: 862  TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQR------NPKQLLANQNNPMMPRPPTLG 915

Query: 337  LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQ 396
                PS  N   +        +Q LR    L        P  +S+  +T     PN + Q
Sbjct: 916  ----PSNNNNVATFGAGSVGNSQQLRPN--LTHSMASMPPQRTSNVMITSNTTAPNWASQ 969

Query: 397  ALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAP 456
                    +   +QQ+ L + GV    + P  T    +P       +   +   R  + P
Sbjct: 970  --------EGTSKQQEALTSAGV----RFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPP 1017

Query: 457  LPQSTLAQLVIQQQHQQFLEKQKQYQQQ---IHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513
               +   Q+    Q  Q L  Q     +   +  N+L ++ +  L Q G+ L ++   + 
Sbjct: 1018 NQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGIN 1077

Query: 514  GDQAMQEDRAPSSGNSTRS 532
               ++     PS   S+R+
Sbjct: 1078 QPPSLTPSNFPSPNQSSRA 1096



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 86/414 (20%), Positives = 142/414 (34%), Gaps = 64/414 (15%)

Query: 262 FEVTESSVSSSSP-GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMN 320
           F +  S++S+SSP  S P S     TGS             HA+Q+   ++I  +     
Sbjct: 391 FSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQL---KQIAANRQQHA 447

Query: 321 LLSLYTSPSLPNITLGLP--AVPSQLNASNSLKEKQKCETQTLR-QGVPLPGQYGGS--- 374
            +  +     P     LP  A PS                QT   Q  P+PG  GGS   
Sbjct: 448 RMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQS 507

Query: 375 -----------IPASSSHPHVTLEGKPPNSSHQALLQ-HLLLKEQMRQQKLLVAGGVPLH 422
                        A   H  V ++ KP + S   +   H  ++ +    K L       H
Sbjct: 508 KVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPL------FH 561

Query: 423 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 482
             S  A ++   P +  +   P    L+ TQ     Q    Q   QQQ QQ  ++Q+Q Q
Sbjct: 562 FNSDQANQQM--PSVLPSQNKPSL--LHYTQQQQQQQQQQQQQ--QQQQQQQQQQQQQQQ 615

Query: 483 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 542
           QQ      +S   +Q +Q     ++ +++ Q  Q  Q+ +        +  SS       
Sbjct: 616 QQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLP 675

Query: 543 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 602
            Q     +   P+   +   +Q+M++                         P+A +G   
Sbjct: 676 SQ----PLLRSPLPLQQKLLLQQMQN------------------------QPIAGMGYQV 707

Query: 603 LEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTT 656
            ++ R     HS    +  P P+ +    P + +G       L +Q + G   T
Sbjct: 708 SQQQR--QDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQT 759



 Score = 37.0 bits (84), Expect = 0.100
 Identities = 21/98 (21%), Positives = 52/98 (53%), Gaps = 5/98 (5%)

Query: 55  QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQ 114
           Q  Q    +L ++ +    + T+Q Q Q Q+  + QQ+     QQQ+  +++Q+ +QQ+Q
Sbjct: 566 QANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQQQQQQ 620

Query: 115 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 152
           +  +   +++QQ   +  + + +++     + +Q+ Q+
Sbjct: 621 QSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQ 658


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,521,034
Number of Sequences: 37866
Number of extensions: 2255611
Number of successful extensions: 21677
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 651
Number of HSP's that attempted gapping in prelim test: 10395
Number of HSP's gapped (non-prelim): 5864
length of query: 1069
length of database: 18,247,518
effective HSP length: 113
effective length of query: 956
effective length of database: 13,968,660
effective search space: 13354038960
effective search space used: 13354038960
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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