BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] (1069 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 2123 0.0 gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 2112 0.0 gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1994 0.0 gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 1702 0.0 gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 1173 0.0 gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 1173 0.0 gi|153085395 histone deacetylase 4 [Homo sapiens] 1143 0.0 gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 1121 0.0 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 674 0.0 gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 652 0.0 gi|13128864 histone deacetylase 6 [Homo sapiens] 282 1e-75 gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 236 1e-61 gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 202 1e-51 gi|116284376 histone deacetylase 2 [Homo sapiens] 111 3e-24 gi|13128860 histone deacetylase 1 [Homo sapiens] 110 7e-24 gi|8923769 histone deacetylase 8 [Homo sapiens] 107 5e-23 gi|13128862 histone deacetylase 3 [Homo sapiens] 90 1e-17 gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 67 7e-11 gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 67 7e-11 gi|221139761 zinc finger protein 853 [Homo sapiens] 66 2e-10 gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 63 2e-09 gi|17017963 forkhead box P2 isoform I [Homo sapiens] 59 3e-08 gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 58 4e-08 gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 58 5e-08 gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 55 3e-07 gi|149999352 forkhead box P2 isoform II [Homo sapiens] 55 4e-07 gi|22538413 forkhead box P2 isoform III [Homo sapiens] 55 5e-07 gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 54 8e-07 gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 54 1e-06 gi|33286444 mastermind-like 2 [Homo sapiens] 53 1e-06 >gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] Length = 1069 Score = 2123 bits (5500), Expect = 0.0 Identities = 1069/1069 (100%), Positives = 1069/1069 (100%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM Sbjct: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH Sbjct: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL Sbjct: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV Sbjct: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI Sbjct: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP Sbjct: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900 Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD Sbjct: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960 Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP Sbjct: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020 Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL Sbjct: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069 >gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] Length = 1066 Score = 2112 bits (5472), Expect = 0.0 Identities = 1066/1069 (99%), Positives = 1066/1069 (99%), Gaps = 3/1069 (0%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117 Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177 Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237 Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297 Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357 Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417 Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477 Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537 Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597 Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657 Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717 Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777 Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837 Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897 Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD Sbjct: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957 Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP Sbjct: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1017 Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL Sbjct: 1018 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066 >gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] Length = 1011 Score = 1994 bits (5165), Expect = 0.0 Identities = 1005/1008 (99%), Positives = 1005/1008 (99%), Gaps = 3/1008 (0%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117 Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177 Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237 Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297 Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357 Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417 Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477 Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537 Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597 Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657 Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717 Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777 Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837 Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897 Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD Sbjct: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957 Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1008 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS Sbjct: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005 >gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] Length = 879 Score = 1702 bits (4409), Expect = 0.0 Identities = 860/863 (99%), Positives = 860/863 (99%), Gaps = 3/863 (0%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117 Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177 Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237 Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297 Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357 Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417 Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477 Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537 Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597 Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657 Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717 Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777 Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837 Query: 841 LYISLHRYDEGNFFPGSGAPNEV 863 LYISLHRYDEGNFFPGSGAPNEV Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEV 860 >gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] Length = 1123 Score = 1173 bits (3035), Expect = 0.0 Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%) Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51 +HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL Sbjct: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82 Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109 ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L +++Q+L Sbjct: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142 Query: 110 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164 EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+ Sbjct: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200 Query: 165 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221 G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT Sbjct: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258 Query: 222 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276 ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS Sbjct: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318 Query: 277 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336 GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG Sbjct: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376 Query: 337 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389 L A S L AS L +Q+ E Q +LRQG L G++ + V LEG Sbjct: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436 Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449 H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL Sbjct: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494 Query: 450 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507 +RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE Sbjct: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552 Query: 508 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557 EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S Sbjct: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612 Query: 558 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615 +E ++E +G + F L+P L V QAPL+ + H+ + RT SS Sbjct: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663 Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675 PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG Sbjct: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723 Query: 676 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735 LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG Sbjct: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783 Query: 736 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795 G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF Sbjct: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843 Query: 796 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855 CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP Sbjct: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903 Query: 856 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915 GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG Sbjct: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963 Query: 916 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975 FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL Sbjct: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023 Query: 976 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033 L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE Sbjct: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083 Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069 ETVSA+A L+V EQ A + R A EPME+EPAL Sbjct: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123 >gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] Length = 1122 Score = 1173 bits (3035), Expect = 0.0 Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%) Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51 +HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL Sbjct: 25 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81 Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109 ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L +++Q+L Sbjct: 82 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141 Query: 110 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164 EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+ Sbjct: 142 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199 Query: 165 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221 G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT Sbjct: 200 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257 Query: 222 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276 ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS Sbjct: 258 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317 Query: 277 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336 GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG Sbjct: 318 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375 Query: 337 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389 L A S L AS L +Q+ E Q +LRQG L G++ + V LEG Sbjct: 376 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435 Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449 H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL Sbjct: 436 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493 Query: 450 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507 +RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE Sbjct: 494 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551 Query: 508 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557 EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S Sbjct: 552 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611 Query: 558 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615 +E ++E +G + F L+P L V QAPL+ + H+ + RT SS Sbjct: 612 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662 Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675 PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG Sbjct: 663 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722 Query: 676 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735 LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG Sbjct: 723 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782 Query: 736 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795 G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF Sbjct: 783 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842 Query: 796 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855 CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP Sbjct: 843 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902 Query: 856 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915 GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG Sbjct: 903 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 962 Query: 916 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975 FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL Sbjct: 963 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1022 Query: 976 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033 L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE Sbjct: 1023 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1082 Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069 ETVSA+A L+V EQ A + R A EPME+EPAL Sbjct: 1083 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122 >gi|153085395 histone deacetylase 4 [Homo sapiens] Length = 1084 Score = 1143 bits (2956), Expect = 0.0 Identities = 629/1093 (57%), Positives = 781/1093 (71%), Gaps = 57/1093 (5%) Query: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59 ++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI Sbjct: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84 Query: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVE 119 Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK QQE+LA+K QQELLE ++KLE+ RQEQE+E Sbjct: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144 Query: 120 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 179 + REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W Sbjct: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202 Query: 180 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 239 Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE Sbjct: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262 Query: 240 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 299 RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P Sbjct: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321 Query: 300 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 359 + AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++ Sbjct: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379 Query: 360 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 417 L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G Sbjct: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433 Query: 418 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 474 +PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF Sbjct: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489 Query: 475 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 528 LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P Sbjct: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547 Query: 529 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 580 + Q G V+VK+EP++SDE+ Q S ++ F QQ L Sbjct: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596 Query: 581 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 638 E L QA + A G+ HR +SR SSPA++ P + P +P TG+ Sbjct: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656 Query: 639 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 698 YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS Sbjct: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716 Query: 699 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 758 E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV Sbjct: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775 Query: 759 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 818 GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL Sbjct: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835 Query: 819 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 878 IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T Sbjct: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895 Query: 879 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 938 GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+ Sbjct: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955 Query: 939 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 998 LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV Sbjct: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015 Query: 999 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1056 S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ + Sbjct: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071 Query: 1057 RTAGEPMEEEPAL 1069 R EPMEEEP L Sbjct: 1072 RPDEEPMEEEPPL 1084 >gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] Length = 590 Score = 1121 bits (2899), Expect = 0.0 Identities = 574/577 (99%), Positives = 574/577 (99%), Gaps = 3/577 (0%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117 Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177 Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237 Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297 Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357 Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417 Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477 Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537 Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 577 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 674 bits (1738), Expect = 0.0 Identities = 450/1018 (44%), Positives = 568/1018 (55%), Gaps = 123/1018 (12%) Query: 83 LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142 LQ +L L QQ+ + +L E++ +EQ+L L KD+ + AVA Sbjct: 61 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120 Query: 143 STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199 S+ VKQKL E +L K + N L A + L PP+ Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177 Query: 200 PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259 +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + S ++ Sbjct: 178 -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227 Query: 260 RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQRILIHE 316 R E S SSS+P SG SSPN+ G P P + + QR+ + E Sbjct: 228 RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQRLRLQE 276 Query: 317 DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP---------L 367 S+ +L T LP ITLGLPA P++ ++ L G P L Sbjct: 277 TSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLFLPHGL 333 Query: 368 PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPL 427 + GG++P S P + L+ P+ SH LL L G +P H L Sbjct: 334 EPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSL 377 Query: 428 ATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHM 487 T ER+S H PL+RT+S PLP S A Q LE+ K + Q Sbjct: 378 MTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ---- 425 Query: 488 NKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGA 547 ++ +S + ++P + E+L+ D VDD L Sbjct: 426 --VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH--- 465 Query: 548 VKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHR 607 +E E ++ Q +Q L R S L + G HR Sbjct: 466 ---RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HR 518 Query: 608 LVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNST 655 +SR SSPAA P PA + S TG+ YD +MLKHQC CG+++ Sbjct: 519 PLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNS 578 Query: 656 THPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKL 715 HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KL Sbjct: 579 RHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKL 638 Query: 716 DPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKN 775 D L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKN Sbjct: 639 DNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKN 698 Query: 776 GFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFY 835 GFAVVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY Sbjct: 699 GFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFY 758 Query: 836 ADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFR 895 DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR Sbjct: 759 QDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFR 818 Query: 896 TIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLAL 955 +V P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLAL Sbjct: 819 IVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLAL 878 Query: 956 EGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVR 1015 EGGHDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++ Sbjct: 879 EGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 938 Query: 1016 MVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067 +A VPR + GA +EE E V+ALASL+V + ED + EEEP Sbjct: 939 RLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 988 >gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] Length = 954 Score = 652 bits (1683), Expect = 0.0 Identities = 440/1010 (43%), Positives = 549/1010 (54%), Gaps = 144/1010 (14%) Query: 83 LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142 LQ +L L QQ+ + +L E++ +EQ+L L KD+ + AVA Sbjct: 61 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120 Query: 143 STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199 S+ VKQKL E +L K + N L A + L PP+ Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177 Query: 200 PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259 +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + S ++ Sbjct: 178 -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227 Query: 260 RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHED 317 R E S SSS+P SG SSPN+ G P P R Sbjct: 228 RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR------ 270 Query: 318 SMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSI 375 T P+L LG P P L L + GG++ Sbjct: 271 -------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPEAGGTL 304 Query: 376 PASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISP 435 P S P + L+ P+ SH LL L G +P H L T ER+S Sbjct: 305 P-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTTERLSG 348 Query: 436 GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 495 H PL+RT+S PLP S A Q LE+ K + Q ++ +S Sbjct: 349 S-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------VIKRSA 394 Query: 496 EQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPV 555 + ++P + E+L+ D VDD L +E Sbjct: 395 KPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------RELGH 433 Query: 556 DSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615 E ++ Q +Q L R S L + G HR +SR SS Sbjct: 434 GQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLSRAQSS 489 Query: 616 PAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHPEHAGR 663 PAA P PA + S TG+ YD +MLKHQC CG+++ HPEHAGR Sbjct: 490 PAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGR 549 Query: 664 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 723 IQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KLD L G Sbjct: 550 IQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGL 609 Query: 724 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 783 +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFAVVRPP Sbjct: 610 LAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPP 669 Query: 784 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 843 GHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY DPS+LYI Sbjct: 670 GHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYI 729 Query: 844 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903 SLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V P+A+ Sbjct: 730 SLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 789 Query: 904 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 963 EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLALEGGHDLTA Sbjct: 790 EFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTA 849 Query: 964 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA----- 1018 ICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++ +A Sbjct: 850 ICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDS 909 Query: 1019 -VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067 VPR + GA +EE E V+ALASL+V + ED + EEEP Sbjct: 910 WVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951 >gi|13128864 histone deacetylase 6 [Homo sapiens] Length = 1215 Score = 282 bits (722), Expect = 1e-75 Identities = 169/408 (41%), Positives = 234/408 (57%), Gaps = 39/408 (9%) Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675 P +L P + S TG+ YD M+ H C +S HPE RI I RL+E G Sbjct: 467 PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518 Query: 676 LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 734 L +C + R A+ E+ HS E+ L T + ++L +S F S C Sbjct: 519 LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572 Query: 735 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 794 + A++A G L V SGE+ NG AVVRPPGHHAE+ A G Sbjct: 573 PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619 Query: 795 FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 853 FCFFNSVA+ A++ + + +ILIVD DVHHGNGTQ F DPS+LY+SLHRYD G F Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679 Query: 854 FP--GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVL 911 FP GA +++G G G+ +N+AW G P MGD +YL A+ +V P+A EF+P++VL Sbjct: 680 FPMGDEGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVL 736 Query: 912 VSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEAC 971 VSAGFDA G PLGG +V+ + + HLT LM LA GR++L LEGG++LT+I ++ AC Sbjct: 737 VSAGFDAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAAC 794 Query: 972 VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAV 1019 +LLG +P L + P A+ S+ + I++ +YW+S+R++ V Sbjct: 795 TRSLLG---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV 839 Score = 236 bits (603), Expect = 7e-62 Identities = 143/382 (37%), Positives = 212/382 (55%), Gaps = 32/382 (8%) Query: 634 SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 693 + TG+ D + + C+ +S PE R+ +I +L + GLL++C Q R A EE+ Sbjct: 84 AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141 Query: 694 QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 752 LVHS E+ L+ T ++ +L R+L D+++ +S Sbjct: 142 MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182 Query: 753 AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 812 A +A G V+ L V E++NG A++RPPGHHA+ S G+C FN VA+ A+Y + + Sbjct: 183 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242 Query: 813 NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEG 870 I ++LIVD DVHHG GTQ F DPS+LY S+HRY++G F+P A N G G G+G Sbjct: 243 RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQG 302 Query: 871 YNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYK 930 Y IN+ W M D +Y+ AF ++ PVA EF P +VLV+AGFDAL+G P G Sbjct: 303 YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMA 357 Query: 931 VTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQ 990 T F LT LM LA G+++L+LEGG++L A+ + A ++ LLG+ P+ E Sbjct: 358 ATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPC-PMLES--PG 414 Query: 991 SPNMNAVISLQKIIEIQSKYWK 1012 +P +A S+ +E +W+ Sbjct: 415 APCRSAQASVSCALEALEPFWE 436 >gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] Length = 669 Score = 236 bits (601), Expect = 1e-61 Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%) Query: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 Query: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 Query: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 Query: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 Query: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932 +N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 Query: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 Query: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366 >gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] Length = 649 Score = 202 bits (514), Expect = 1e-51 Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%) Query: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 Query: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 Query: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 Query: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 Query: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932 +N+ W MG+ +Y+ AF ++ P+A E G + T Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258 Query: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315 Query: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 316 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346 >gi|116284376 histone deacetylase 2 [Homo sapiens] Length = 582 Score = 111 bits (278), Expect = 3e-24 Identities = 105/384 (27%), Positives = 168/384 (43%), Gaps = 61/384 (15%) Query: 657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 712 HP RI+ + L GL K E + KA+ EE+ HS+ + + N + Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182 Query: 713 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767 K R +G+D F F L GG V N + A A G Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234 Query: 768 VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 827 HHA++S A GFC+ N + + L ++L +D+D+HHG Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275 Query: 828 NGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGD 887 +G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D D Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329 Query: 888 VEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLA 947 Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + + Sbjct: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVVK 384 Query: 948 DGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP-N 993 + L + GG T A C E V + + NEL E D LH SP N Sbjct: 385 TFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN 444 Query: 994 MNAVISLQKIIEIQSKYWKSVRMV 1017 M + + + +I+ + ++++RM+ Sbjct: 445 MTNQNTPEYMEKIKQRLFENLRML 468 >gi|13128860 histone deacetylase 1 [Homo sapiens] Length = 482 Score = 110 bits (275), Expect = 7e-24 Identities = 105/385 (27%), Positives = 170/385 (44%), Gaps = 63/385 (16%) Query: 657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 712 HP RI+ + L GL K E + KA+ EE+ HS+ + + N + Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87 Query: 713 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767 K R +G+D F F L GG +AS Sbjct: 88 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121 Query: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 826 V + + AV G HHA++S A GFC+ N + + L ++L +D+D+HH Sbjct: 122 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179 Query: 827 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 886 G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID---- 233 Query: 887 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 946 D Y F+ ++ V + F P V++ G D+L G LG + +T K GH K + + Sbjct: 234 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR--LGCFNLTIK--GH-AKCVEFV 288 Query: 947 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 992 + + + GG T A C E V + + NEL E D LH SP Sbjct: 289 KSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPS 348 Query: 993 NMNAVISLQKIIEIQSKYWKSVRMV 1017 NM + + + +I+ + ++++RM+ Sbjct: 349 NMTNQNTNEYLEKIKQRLFENLRML 373 >gi|8923769 histone deacetylase 8 [Homo sapiens] Length = 377 Score = 107 bits (268), Expect = 5e-23 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%) Query: 626 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 682 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 Query: 683 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 740 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 Query: 741 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 798 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 Query: 799 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 858 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 Query: 859 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 918 ++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268 Query: 919 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 978 + G P+ + +T G K ++ ++L GG++L +LG Sbjct: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325 Query: 979 EL 980 L Sbjct: 326 TL 327 >gi|13128862 histone deacetylase 3 [Homo sapiens] Length = 428 Score = 89.7 bits (221), Expect = 1e-17 Identities = 47/136 (34%), Positives = 74/136 (54%), Gaps = 9/136 (6%) Query: 785 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 844 HHA++ A GFC+ N + I L ++L +D+D+HHG+G Q+AFY ++ +S Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191 Query: 845 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903 H+Y GN FFPG+G EVG G Y +N+ G+D D Y F+ ++ V Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245 Query: 904 EFDPDMVLVSAGFDAL 919 + P +++ G D+L Sbjct: 246 FYQPTCIVLQCGADSL 261 >gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] Length = 347 Score = 67.4 bits (163), Expect = 7e-11 Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%) Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 709 G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L + Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89 Query: 710 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767 ++ P I L + +K L R G I +A K Sbjct: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126 Query: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 825 +A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183 Query: 826 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 885 GNG ++ F D + + ++ + +PG + + + W G + Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230 Query: 886 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 945 D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + + Sbjct: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287 Query: 946 LADGR---VVLALEGGH 959 + GR +++ GG+ Sbjct: 288 MVRGRRVPILMVTSGGY 304 >gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] Length = 296 Score = 67.4 bits (163), Expect = 7e-11 Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%) Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 711 G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56 Query: 712 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 771 + L P R G I +A K+A Sbjct: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77 Query: 772 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 829 ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG Sbjct: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136 Query: 830 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 889 ++ F D + + ++ + +PG + + + W G + D E Sbjct: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182 Query: 890 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 949 YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G Sbjct: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240 Query: 950 R---VVLALEGGH 959 R +++ GG+ Sbjct: 241 RRVPILMVTSGGY 253 >gi|221139761 zinc finger protein 853 [Homo sapiens] Length = 659 Score = 65.9 bits (159), Expect = 2e-10 Identities = 44/114 (38%), Positives = 68/114 (59%), Gaps = 7/114 (6%) Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ-ELLAIKQQQELL 103 Q QQ+LLL+QQQ Q+Q+QLL + + + L Q QAQLQ+ + LQQ E L +QQQ+LL Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295 Query: 104 EKEQKLEQQRQ------EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151 +++Q+ QQ+Q E E E + +P G ++ E+ E +Q+L+ Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELE 349 Score = 58.2 bits (139), Expect = 4e-08 Identities = 38/93 (40%), Positives = 65/93 (69%), Gaps = 7/93 (7%) Query: 42 REKQLQQELLLIQQQQ-QIQKQLLIAEFQKQ-HENLTRQHQAQLQEHIKLQQELLAIKQQ 99 +++QLQQ+ QQ+Q Q Q+QLL+ + Q Q + L +Q QAQLQ+ + QQ+ A QQ Sbjct: 219 QQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQ--AQLQQ 276 Query: 100 QELLEKEQKLEQQRQEQEVERHR---REQQLPP 129 Q LL+++++L+QQ+Q+Q +++ + ++QQL P Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQP 309 Score = 57.8 bits (138), Expect = 5e-08 Identities = 40/100 (40%), Positives = 65/100 (65%), Gaps = 15/100 (15%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAE--------FQKQHENLTRQHQ-AQLQEHIKLQQEL 93 ++Q+Q++ LL QQQ+Q+Q+Q L+ + FQ+Q E L +Q Q LQ+ +LQQ+L Sbjct: 195 QQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQL 254 Query: 94 LAIKQ---QQELLEKEQKLEQQR---QEQEVERHRREQQL 127 L +Q QQ+LLE++Q QQ+ Q+QE + +++QQL Sbjct: 255 LQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQL 294 Score = 57.0 bits (136), Expect = 9e-08 Identities = 42/102 (41%), Positives = 64/102 (62%), Gaps = 18/102 (17%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKLQQELLAIK 97 ++ QLQQ+LL QQQ Q+Q+QLL+ + Q+Q + L +Q Q QLQ+ +LQ L + Sbjct: 258 QQAQLQQQLLE-QQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQ-QLQPPPLEPE 315 Query: 98 QQQEL--------LEKEQKLEQQRQE----QEVERHRREQQL 127 +++E+ L EQ+LEQQRQE QE+ER + ++QL Sbjct: 316 EEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357 Score = 55.8 bits (133), Expect = 2e-07 Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%) Query: 338 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 393 PAV + + AS +E +++ + Q L Q P P Q PH+ L+ +P Sbjct: 67 PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125 Query: 394 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453 Q L Q L+++ Q +H Q + P ++ H+ + +P + Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166 Query: 454 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513 L Q Q Q QQ L++Q+Q QQQ+ +LL + EQL+Q L + +E+LQ Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224 Query: 514 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 573 Q Q+ + + GQ+ ++ + + AQ+Q+ +Q A Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272 Query: 574 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 608 +QQ L + +Q L + L++ +L Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307 Score = 55.8 bits (133), Expect = 2e-07 Identities = 37/128 (28%), Positives = 80/128 (62%), Gaps = 7/128 (5%) Query: 33 MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQE 92 + P + + +++QLQ + +Q+QQ++Q+Q + Q+ E Q Q QLQ+ ++ QQ Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203 Query: 93 LLAIK---QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149 L + QQQ+LL+++++L+QQ+ +Q+ E+ +++QQL L+ + + +++ + + + Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQ-- 261 Query: 150 LQEFLLSK 157 LQ+ LL + Sbjct: 262 LQQQLLEQ 269 Score = 49.7 bits (117), Expect = 1e-05 Identities = 36/117 (30%), Positives = 69/117 (58%), Gaps = 10/117 (8%) Query: 41 VREKQLQQELLLIQQ---QQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIK 97 ++ +Q Q++ +L QQ QQQ+Q+Q L+ Q+Q E L +Q Q QE ++ QQ + Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLL---QQQQEQLQQQQLLQQQEQLQQQQ----FQ 229 Query: 98 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154 QQQE L+++Q+L +Q+ ++++ +QQ L+ + +++A ++ + QE L Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286 Score = 49.7 bits (117), Expect = 1e-05 Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 30/132 (22%) Query: 44 KQLQQELLLIQQQQQIQKQLLIA------------------------EFQKQHENLTRQH 79 +Q QQ+ LL QQQ+Q+Q+Q L E ++Q + L RQ Sbjct: 287 QQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346 Query: 80 QAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139 + + Q+ +Q L +K Q+EL + EQ+LEQQ +Q++E+ + +L P+ + +E Sbjct: 347 ELERQQ----EQRQLQLKLQEELQQLEQQLEQQ--QQQLEQQEVQLELTPVELGAQQQEV 400 Query: 140 AVASTEVKQKLQ 151 + T V+ +LQ Sbjct: 401 QLELTPVQPELQ 412 Score = 43.5 bits (101), Expect = 0.001 Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 12/109 (11%) Query: 47 QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLE 104 QQ+L +QQ+ Q + Q L E Q H+ Q Q Q+QE +LQQ QQE L+ Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQ-QVQEQQRLQQ-------QQEQLQ 178 Query: 105 KEQKLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151 +Q EQQ +Q++++++ +EQQL + + +++ + E Q+ Q Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227 Score = 43.1 bits (100), Expect = 0.001 Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 20/111 (18%) Query: 35 PVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQ-HENLTRQ--------------- 78 P P + Q Q L +QQQ Q Q +++ Q++ H+++ Q Sbjct: 100 PQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQL 159 Query: 79 --HQAQLQEHIKLQQELLAIK--QQQELLEKEQKLEQQRQEQEVERHRREQ 125 Q Q Q+ ++ QQE L + Q+Q++L+++++L+QQ QEQ++ + ++EQ Sbjct: 160 QPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQ 210 Score = 42.4 bits (98), Expect = 0.002 Identities = 38/132 (28%), Positives = 69/132 (52%), Gaps = 20/132 (15%) Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIA-----EFQKQHENLTRQHQAQLQE-------H 86 P RE QLQQ + QQQ Q + L E Q+Q + +Q +QLQ+ H Sbjct: 84 PGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHH 143 Query: 87 IKLQQELLAIKQQQEL----LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142 +L+ EL + QQQ+L ++++Q+L+QQ+++ + ++ + +Q L + ++ V Sbjct: 144 QELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQ----QQEQLQQQVQ 199 Query: 143 STEVKQKLQEFL 154 ++ Q+ QE L Sbjct: 200 EQQLLQQQQEQL 211 Score = 35.0 bits (79), Expect = 0.38 Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%) Query: 396 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453 Q LQ LL++Q Q Q+LL L Q L +E++ + + L + Q Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306 Query: 454 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499 P P + ++ +Q +Q LE+Q++ ++Q +L K E+L+ Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366 Query: 500 QPGSHLEEAEEELQGDQAMQE 520 Q LE+ +++L+ + E Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387 Score = 32.0 bits (71), Expect = 3.2 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%) Query: 396 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 447 Q LLQ +EQ++QQ+L PL P+ + + P G+ + L R + Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346 Query: 448 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 506 L R Q + QL +Q++ QQ ++ +Q QQQ+ ++ L + +L G+ + Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398 Query: 507 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 552 E + EL Q +Q + P++G + A + G V V+E Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445 Score = 30.4 bits (67), Expect = 9.3 Identities = 32/115 (27%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 15 PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74 P LEP ++ +L MPV + E++L+Q+ +++QQ++++Q + Q + + Sbjct: 309 PPPLEPEEEEEVELEL---MPV--DLGSEQELEQQRQELERQQELERQQEQRQLQLKLQE 363 Query: 75 LTRQHQAQL--QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQL 127 +Q + QL Q+ QQE+ Q EL E +QQ + E+ + E QL Sbjct: 364 ELQQLEQQLEQQQQQLEQQEV-----QLELTPVELGAQQQEVQLELTPVQPELQL 413 >gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] Length = 748 Score = 62.8 bits (151), Expect = 2e-09 Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 63/373 (16%) Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87 M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q Q + Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194 Query: 88 KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140 +QQ+ A+ QQQ+ L+++Q KL Q Q+Q ++ ++ Q++ L+ + + +++ Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254 Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199 + +Q LQ + P + ++ + + + HH Q PP++ Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314 Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255 PS T P A+ P + ++P LK R V + P ++++ V T Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372 Query: 256 SFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVS 308 + +M +V++SS +SS SPG +P + +PP P Sbjct: 373 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS-------------MPPPPQPSPQPG 419 Query: 309 QQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ--GVP 366 Q +S N++ G PS S S + Q T Q VP Sbjct: 420 QP---------------SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVP 464 Query: 367 LPGQYGGSIPASS 379 PG + SS Sbjct: 465 SPGPLNTPVNPSS 477 Score = 40.4 bits (93), Expect = 0.009 Identities = 85/436 (19%), Positives = 157/436 (36%), Gaps = 76/436 (17%) Query: 84 QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAS 143 Q ++LQQ L +QQQ+ +++Q+ Q+Q+Q+ ++ + + Q ++ + + + Sbjct: 150 QTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQ 209 Query: 144 TEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYK 203 + +Q+ Q+ L+ + + R +L L Q + Sbjct: 210 LQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQ 261 Query: 204 YTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFE 263 L AQ P+++ P+ + +L+Q + P Sbjct: 262 QALQ-AQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQP------------------- 301 Query: 264 VTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLS 323 P P P V +N+ S LPP + +VSQ + L + Sbjct: 302 --------------PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------M 338 Query: 324 LYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSH 381 LYT P L + P V Q ++++Q + PG S+P SS Sbjct: 339 LYTQPPLKFVRA--PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS- 395 Query: 382 PHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISP 435 P + + P S + Q V+ G P S P ++ ++ Sbjct: 396 PSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTA 455 Query: 436 GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKS 494 +P PLN + P S ++ Q + QQ+L+K KQ LSK Sbjct: 456 RTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKY 502 Query: 495 IEQLKQPGSHLEEAEE 510 IE L++ + +++ E+ Sbjct: 503 IEPLRRMINKIDKNED 518 Score = 37.0 bits (84), Expect = 0.100 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%) Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493 GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ + Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191 Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553 ++Q + + +++LQ Q Q+ + + L ++ ++++++ Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249 Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613 + Q Q+ Q Q P +P + P A+ + H ++ H Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299 Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652 P P A ++P L P S T PL+ + Q + G Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336 >gi|17017963 forkhead box P2 isoform I [Homo sapiens] Length = 715 Score = 58.5 bits (140), Expect = 3e-08 Identities = 46/182 (25%), Positives = 91/182 (50%), Gaps = 4/182 (2%) Query: 23 PLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQ 80 PL + + MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + ++ Q Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143 Query: 81 AQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140 QL + LQQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK ++ Sbjct: 144 EQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQ 202 Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTS 199 + + Q+ + + + + H +S + L +L S P +G S Sbjct: 203 QQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLS 262 Query: 200 PS 201 P+ Sbjct: 263 PA 264 Score = 40.0 bits (92), Expect = 0.012 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%) Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486 + T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H Sbjct: 93 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147 Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546 + L + +Q +Q ++ +++ Q Q Q+ + A Q Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207 Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604 ++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++ Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267 Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655 + + V+ HS + H +D S+T + P + H V G S+ Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322 >gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [Homo sapiens] Length = 1166 Score = 58.2 bits (139), Expect = 4e-08 Identities = 63/259 (24%), Positives = 114/259 (44%), Gaps = 21/259 (8%) Query: 43 EKQLQQELLLIQQQQQ-----IQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKLQQELLAI 96 E L+++ L +QQ+ + +++Q L+ E Q ++ E RQ A+ Q+ I+ Q+E Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408 Query: 97 KQQQELLEKEQKLEQQRQE--QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154 ++Q+ E+E + +Q+R++ +E E RR ++L R ++ R RA ++ QE++ Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468 Query: 155 LSKSATKDTPTNGKNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ 210 + + + + + + H Q PP S PS+ P A Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAH 528 Query: 211 ----DAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVT 265 D + P+R T+ P L R Q ++ S R N +S + R ++E Sbjct: 529 YEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERV 584 Query: 266 ESSVSSSSPGSGPSSPNNG 284 E V GS S N+G Sbjct: 585 EKLVPRPGSGSSSGSSNSG 603 >gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] Length = 788 Score = 57.8 bits (138), Expect = 5e-08 Identities = 108/497 (21%), Positives = 192/497 (38%), Gaps = 99/497 (19%) Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87 M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q Q + Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194 Query: 88 KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140 +QQ+ A+ QQQ+ L+++Q KL Q Q+Q ++ ++ Q++ L+ + + +++ Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254 Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199 + +Q LQ + P + ++ + + + HH Q PP++ Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314 Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255 PS T P A+ P + ++P LK R V + P ++++ V T Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372 Query: 256 SFKKRMFEVTESSVSSS-SPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILI 314 + +M ++ + + G PT +V+ +S +P VSQ Sbjct: 373 AQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQS---- 428 Query: 315 HEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGS 374 SLP L P+ Q+ S+ Q P PGQ Sbjct: 429 --------------SLP--MLSSPSPGQQVQTPQSMPPPP--------QPSPQPGQ---- 460 Query: 375 IPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERIS 434 P+S + +V+ P SS L SP ++ ++ Sbjct: 461 -PSSQPNSNVSSGPAPSPSSF-------------------------LPSPSPQPSQSPVT 494 Query: 435 PGIRGTHKLPRHRPLNRTQSAPLPQSTLAQL-VIQQQHQQFLEKQKQYQQQIHMNKLLSK 493 +P PLN + P S ++ Q + QQ+L+K KQ LSK Sbjct: 495 ARTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSK 541 Query: 494 SIEQLKQPGSHLEEAEE 510 IE L++ + +++ E+ Sbjct: 542 YIEPLRRMINKIDKNED 558 Score = 37.0 bits (84), Expect = 0.100 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%) Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493 GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ + Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191 Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553 ++Q + + +++LQ Q Q+ + + L ++ ++++++ Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249 Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613 + Q Q+ Q Q P +P + P A+ + H ++ H Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299 Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652 P P A ++P L P S T PL+ + Q + G Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336 >gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo sapiens] Length = 5537 Score = 55.5 bits (132), Expect = 3e-07 Identities = 46/168 (27%), Positives = 81/168 (48%), Gaps = 7/168 (4%) Query: 42 REKQLQQELLLIQQQQQ-IQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQ 100 +++QLQQ+ L QQQQQ +Q+Q + + Q Q + +Q Q Q Q+ ++ QQ+ L +QQQ Sbjct: 3902 QQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQ 3961 Query: 101 ELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT 160 + +Q+ +QQ+Q+Q++ + + L L + + +++ + K + S A Sbjct: 3962 Q----QQQFQQQQQQQQMGLLNQSRTL--LSPQQQQQQQVALGPGMPAKPLQHFSSPGAL 4015 Query: 161 KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 208 T + P + A S Q P GT+P T PG Sbjct: 4016 GPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063 Score = 43.1 bits (100), Expect = 0.001 Identities = 139/663 (20%), Positives = 236/663 (35%), Gaps = 140/663 (21%) Query: 43 EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQE 101 E ++ L+ +QQ +IQKQL + + QK+H NL +++ KQQQ+ Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN---------------KQQQQ 3602 Query: 102 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATK 161 +Q+ +QQ+Q+ Q P L K G+ + Q + Sbjct: 3603 ----QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLR 3656 Query: 162 DTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKT 221 TP P L A S S PS + PG + P + Sbjct: 3657 LTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRL 3715 Query: 222 ASEPNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG 277 E L++ R +L QK+ +++ ++ G V +++ +++ + G Sbjct: 3716 LQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQG 3775 Query: 278 ---PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRIL 313 PSS P GP G + + +VL P PH + +++Q R+L Sbjct: 3776 LMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL 3835 Query: 314 IHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGG 373 +SP L GL + +L + +++Q+ + Q G+ Q Sbjct: 3836 ------------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ--- 3878 Query: 374 SIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERI 433 S+ + S P L +P S Q Q L ++Q QQ+ Q L ++++ Sbjct: 3879 SLMSHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL 3926 Query: 434 SPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSK 493 Q L Q Q + QQQ QQ ++Q+Q QQQ + + Sbjct: 3927 -------------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQ 3967 Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVK 549 +Q +Q G L ++ L Q Q+ A G + S + TL G + Sbjct: 3968 QQQQQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQ 4026 Query: 550 VKEEPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTH 584 +P S E +++ SG+ + QP +P Sbjct: 4027 NTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQP 4086 Query: 585 T--------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPG 633 + R +Q ++ + G H + SS A+SV L P++ QPG Sbjct: 4087 SSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPG 4146 Query: 634 SAT 636 S T Sbjct: 4147 SMT 4149 Score = 42.4 bits (98), Expect = 0.002 Identities = 105/460 (22%), Positives = 169/460 (36%), Gaps = 115/460 (25%) Query: 54 QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQ------ 107 QQQQQ Q+Q +A ++L H Q + + L ++QQQ+L +++Q Sbjct: 3859 QQQQQHQQQGSMAGLSHLQQSLM-SHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQ 3917 Query: 108 ---KLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF----------L 154 + +QQ Q+Q++++ +++QQL + + +++ + +Q+ Q+F L Sbjct: 3918 QQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGL 3977 Query: 155 LSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKD 214 L++S T +P + V+ P + P ++ PGA Sbjct: 3978 LNQSRTLLSPQQQQQQQVALGPGM------------------PAKPLQHFSSPGALG--- 4016 Query: 215 DFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSP 274 P L LL K+ N V + +VSS + Sbjct: 4017 ----------PTL-----------------LLTGKEQNTV-----------DPAVSSEAT 4038 Query: 275 GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNIT 334 GPS+ GP T E+ P + ++L L+ P ++ Sbjct: 4039 -EGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLL-------LVQPQPQPQPSSLQ 4090 Query: 335 LGLP-AVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYG-GSIPASSSHPHVTLE----- 387 L P +P Q SL G GQ G GS +SS PH+ + Sbjct: 4091 LQPPLRLPGQQQQQVSLLH---------TAGGGSHGQLGSGSSSEASSVPHLLAQPSVSL 4141 Query: 388 GKPPNSSHQALL--QHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPR 445 G P S Q LL Q +L+ M+ G P P L + + G+ G +P Sbjct: 4142 GDQPGSMTQNLLGPQQPMLERPMQNN----TGPQPPKPGPVLQSGQ----GLPGVGIMPT 4193 Query: 446 HRPLN-RTQSAPLPQSTLAQLVIQQQHQ-QFLEKQKQYQQ 483 L + Q L L QQQ Q Q L Q+Q QQ Sbjct: 4194 VGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQ 4233 >gi|149999352 forkhead box P2 isoform II [Homo sapiens] Length = 740 Score = 55.1 bits (131), Expect = 4e-07 Identities = 45/185 (24%), Positives = 91/185 (49%), Gaps = 4/185 (2%) Query: 20 PISPLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTR 77 P + + + MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + + Sbjct: 106 PHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYK 165 Query: 78 QHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 137 + Q QL + LQQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK Sbjct: 166 KQQEQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKE 224 Query: 138 ERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLS 196 ++ + + Q+ + + + + H +S + L +L S P + Sbjct: 225 QQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQA 284 Query: 197 GTSPS 201 G SP+ Sbjct: 285 GLSPA 289 Score = 42.4 bits (98), Expect = 0.002 Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 28/283 (9%) Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAG--GVPLHPQSPLA--------TKERISPGIRG 439 P +S Q LQ LL + KL + G HP + A T + I+P + Sbjct: 76 PKSSDKQRPLQELL-----PETKLCICGHSSGDGHPHNTFAVPVSVAMMTPQVITP--QQ 128 Query: 440 THKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499 ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H+ L + +Q + Sbjct: 129 MQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLHLQLLQQQQQQQQQ 185 Query: 500 QPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDE 559 Q ++ +++ Q Q Q+ + A Q ++ V + Sbjct: 186 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQ 245 Query: 560 DAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLEK-HRLVSRTHSSP 616 Q+Q+++ + +Q+ L P AL V+ P A + +++ + V+ HS Sbjct: 246 LLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSME 305 Query: 617 AASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655 + H +D S+T + P + H V G S+ Sbjct: 306 DNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 347 >gi|22538413 forkhead box P2 isoform III [Homo sapiens] Length = 623 Score = 54.7 bits (130), Expect = 5e-07 Identities = 44/173 (25%), Positives = 87/173 (50%), Gaps = 4/173 (2%) Query: 32 MMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQAQLQEHIKL 89 MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + ++ Q QL + L Sbjct: 1 MMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQL-L 59 Query: 90 QQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149 QQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK ++ + + Sbjct: 60 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA 119 Query: 150 LQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTSPS 201 Q+ + + + + H +S + L +L S P +G SP+ Sbjct: 120 AQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPA 172 Score = 40.0 bits (92), Expect = 0.012 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%) Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486 + T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H Sbjct: 1 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 55 Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546 + L + +Q +Q ++ +++ Q Q Q+ + A Q Sbjct: 56 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 115 Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604 ++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++ Sbjct: 116 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 175 Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655 + + V+ HS + H +D S+T + P + H V G S+ Sbjct: 176 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 230 >gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3 [Homo sapiens] Length = 1212 Score = 53.9 bits (128), Expect = 8e-07 Identities = 71/295 (24%), Positives = 121/295 (41%), Gaps = 58/295 (19%) Query: 41 VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-----QAQLQEHIKLQQELLA 95 +R +QL QE L +Q++ K+ L+AE QK+ E Q Q + + + QQE Sbjct: 370 LRRQQLLQEQQLREQEEY--KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQ 427 Query: 96 IKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLL 155 +++QE + ++LE++R+E+E R E++ R ++ R + + LQ+ LL Sbjct: 428 RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLL 487 Query: 156 SKSA--------------TKDTPTNGKNHSVSRH---PKLWYTAA-------------HH 185 + A + P + S H PK Y A +H Sbjct: 488 QEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH 547 Query: 186 TSLDQSS--------PPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKV 237 +S + S PP+ S S+ +++ P + +EP + VR+ + V Sbjct: 548 SSPEAQSKQTGRVLEPPVPSRSESF-----SNGNSESVHPALQRPAEPQVPVRTTSRSPV 602 Query: 238 AERRSSPL-------LRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGPSSPNNG 284 RR SPL + N +S + R ++E E V GS S N+G Sbjct: 603 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSG 657 >gi|41152097 DNA segment on chromosome X and Y (unique) 155 expressed sequence isoform 1 [Homo sapiens] Length = 695 Score = 53.5 bits (127), Expect = 1e-06 Identities = 44/151 (29%), Positives = 80/151 (52%), Gaps = 23/151 (15%) Query: 37 VDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ----- 91 ++ + RE++ +++L ++++Q Q+ + QK+ E L + Q QLQE IKL++ Sbjct: 309 LEELERERKREEKL---RKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLL 365 Query: 92 ------------ELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139 ELL+ + +L E+EQK E+ R +Q+ ER R ++ LR + +ER Sbjct: 366 AQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQE--AELRRVEEEKER 423 Query: 140 AVASTEVKQKLQEFLLSKSATKDTPTNGKNH 170 A+ +++L+E LLS +K P + H Sbjct: 424 ALGLQRKERELRERLLSILLSK-KPDDSHTH 453 Score = 35.4 bits (80), Expect = 0.29 Identities = 22/105 (20%), Positives = 64/105 (60%), Gaps = 8/105 (7%) Query: 55 QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI--KLQQELLAIKQQQELLEKEQKLEQQ 112 +++Q+++Q L Q++ E R+ +A+ ++ + Q+EL ++++++ EK +K EQ+ Sbjct: 269 KKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQK 328 Query: 113 RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 157 ++++E+ R++++ + K + E+ ++K + ++ LL++ Sbjct: 329 QRDRELRRNQKKLE------KLQAEEQKQLQEKIKLEERKLLLAQ 367 Score = 32.0 bits (71), Expect = 3.2 Identities = 24/68 (35%), Positives = 39/68 (57%), Gaps = 11/68 (16%) Query: 95 AIKQQQELLEKEQKLEQQRQEQ-----EVE-----RHRREQQLPPLRGKDRGRERAVAST 144 +IK++Q +K Q+LEQQR+EQ E E R++++L L ++R RE + Sbjct: 267 SIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELE-RERKREEKLRKR 325 Query: 145 EVKQKLQE 152 E KQ+ +E Sbjct: 326 EQKQRDRE 333 >gi|33286444 mastermind-like 2 [Homo sapiens] Length = 1156 Score = 53.1 bits (126), Expect = 1e-06 Identities = 112/559 (20%), Positives = 207/559 (37%), Gaps = 93/559 (16%) Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQEL 93 MP V P + L QQQQQ Q+Q + Q+Q + +Q Q Q Q I QQ+ Sbjct: 571 MPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQ- 629 Query: 94 LAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK---L 150 +QQQ + +Q+ +QQ+Q+Q+ ++ +++QQ + +++ S + + L Sbjct: 630 ---QQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPL 686 Query: 151 QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSP-SYKYTLPGA 209 Q+ LL + ++ P G + VS+ + H+ + Q++ P +P S T G Sbjct: 687 QQKLLLQQ-MQNQPIAGMGYQVSQQQR----QDQHSVVGQNTGPSPSPNPCSNPNTGSGY 741 Query: 210 QDAKDDFPLRKTASEPNLKVRSRLKQKV-----------AER------------RSSPLL 246 +++ ++ + R ++QK AE+ R P Sbjct: 742 MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY 801 Query: 247 RRKDGNVVTSFKKRMFEVTESSVSSSS-----------------------------PGSG 277 + + NV + S++S +S P Sbjct: 802 KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS 861 Query: 278 PSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPN-ITLG 336 + N G G++ N+ + T Q+ Q+ + LL+ +P +P TLG Sbjct: 862 TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQR------NPKQLLANQNNPMMPRPPTLG 915 Query: 337 LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQ 396 PS N + +Q LR L P +S+ +T PN + Q Sbjct: 916 ----PSNNNNVATFGAGSVGNSQQLRPN--LTHSMASMPPQRTSNVMITSNTTAPNWASQ 969 Query: 397 ALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAP 456 + +QQ+ L + GV + P T +P + + R + P Sbjct: 970 --------EGTSKQQEALTSAGV----RFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPP 1017 Query: 457 LPQSTLAQLVIQQQHQQFLEKQKQYQQQ---IHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513 + Q+ Q Q L Q + + N+L ++ + L Q G+ L ++ + Sbjct: 1018 NQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGIN 1077 Query: 514 GDQAMQEDRAPSSGNSTRS 532 ++ PS S+R+ Sbjct: 1078 QPPSLTPSNFPSPNQSSRA 1096 Score = 42.7 bits (99), Expect = 0.002 Identities = 86/414 (20%), Positives = 142/414 (34%), Gaps = 64/414 (15%) Query: 262 FEVTESSVSSSSP-GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMN 320 F + S++S+SSP S P S TGS HA+Q+ ++I + Sbjct: 391 FSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQL---KQIAANRQQHA 447 Query: 321 LLSLYTSPSLPNITLGLP--AVPSQLNASNSLKEKQKCETQTLR-QGVPLPGQYGGS--- 374 + + P LP A PS QT Q P+PG GGS Sbjct: 448 RMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQS 507 Query: 375 -----------IPASSSHPHVTLEGKPPNSSHQALLQ-HLLLKEQMRQQKLLVAGGVPLH 422 A H V ++ KP + S + H ++ + K L H Sbjct: 508 KVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPL------FH 561 Query: 423 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 482 S A ++ P + + P L+ TQ Q Q QQQ QQ ++Q+Q Q Sbjct: 562 FNSDQANQQM--PSVLPSQNKPSL--LHYTQQQQQQQQQQQQQ--QQQQQQQQQQQQQQQ 615 Query: 483 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 542 QQ +S +Q +Q ++ +++ Q Q Q+ + + SS Sbjct: 616 QQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLP 675 Query: 543 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 602 Q + P+ + +Q+M++ P+A +G Sbjct: 676 SQ----PLLRSPLPLQQKLLLQQMQN------------------------QPIAGMGYQV 707 Query: 603 LEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTT 656 ++ R HS + P P+ + P + +G L +Q + G T Sbjct: 708 SQQQR--QDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQT 759 Score = 37.0 bits (84), Expect = 0.100 Identities = 21/98 (21%), Positives = 52/98 (53%), Gaps = 5/98 (5%) Query: 55 QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQ 114 Q Q +L ++ + + T+Q Q Q Q+ + QQ+ QQQ+ +++Q+ +QQ+Q Sbjct: 566 QANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQQQQQQ 620 Query: 115 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 152 + + +++QQ + + + +++ + +Q+ Q+ Sbjct: 621 QSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQ 658 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 44,521,034 Number of Sequences: 37866 Number of extensions: 2255611 Number of successful extensions: 21677 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 266 Number of HSP's successfully gapped in prelim test: 651 Number of HSP's that attempted gapping in prelim test: 10395 Number of HSP's gapped (non-prelim): 5864 length of query: 1069 length of database: 18,247,518 effective HSP length: 113 effective length of query: 956 effective length of database: 13,968,660 effective search space: 13354038960 effective search space used: 13354038960 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.