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Search of human proteins with 30795204
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
(1069 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 2123 0.0
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 2112 0.0
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1994 0.0
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 1702 0.0
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 1173 0.0
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 1173 0.0
gi|153085395 histone deacetylase 4 [Homo sapiens] 1143 0.0
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 1121 0.0
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 674 0.0
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 652 0.0
gi|13128864 histone deacetylase 6 [Homo sapiens] 282 1e-75
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 236 1e-61
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 202 1e-51
gi|116284376 histone deacetylase 2 [Homo sapiens] 111 3e-24
gi|13128860 histone deacetylase 1 [Homo sapiens] 110 7e-24
gi|8923769 histone deacetylase 8 [Homo sapiens] 107 5e-23
gi|13128862 histone deacetylase 3 [Homo sapiens] 90 1e-17
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 67 7e-11
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 67 7e-11
gi|221139761 zinc finger protein 853 [Homo sapiens] 66 2e-10
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 63 2e-09
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 59 3e-08
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 58 4e-08
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 58 5e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 55 3e-07
gi|149999352 forkhead box P2 isoform II [Homo sapiens] 55 4e-07
gi|22538413 forkhead box P2 isoform III [Homo sapiens] 55 5e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 54 8e-07
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 54 1e-06
gi|33286444 mastermind-like 2 [Homo sapiens] 53 1e-06
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 2123 bits (5500), Expect = 0.0
Identities = 1069/1069 (100%), Positives = 1069/1069 (100%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP
Sbjct: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 2112 bits (5472), Expect = 0.0
Identities = 1066/1069 (99%), Positives = 1066/1069 (99%), Gaps = 3/1069 (0%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597
Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657
Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717
Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777
Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837
Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897
Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957
Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP
Sbjct: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1017
Query: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1018 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 1994 bits (5165), Expect = 0.0
Identities = 1005/1008 (99%), Positives = 1005/1008 (99%), Gaps = 3/1008 (0%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597
Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657
Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717
Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777
Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837
Query: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897
Query: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957
Query: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1008
LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS
Sbjct: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 1702 bits (4409), Expect = 0.0
Identities = 860/863 (99%), Positives = 860/863 (99%), Gaps = 3/863 (0%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597
Query: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657
Query: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717
Query: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777
Query: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837
Query: 841 LYISLHRYDEGNFFPGSGAPNEV 863
LYISLHRYDEGNFFPGSGAPNEV
Sbjct: 838 LYISLHRYDEGNFFPGSGAPNEV 860
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 1173 bits (3035), Expect = 0.0
Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%)
Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L +++Q+L
Sbjct: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
Query: 110 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
Query: 165 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
Query: 222 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
Query: 277 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
Query: 337 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
Query: 450 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
Query: 508 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
Query: 558 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
Query: 676 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
Query: 736 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
Query: 796 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
Query: 856 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963
Query: 916 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023
Query: 976 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083
Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 1173 bits (3035), Expect = 0.0
Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%)
Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 25 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81
Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L +++Q+L
Sbjct: 82 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141
Query: 110 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 142 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199
Query: 165 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 200 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257
Query: 222 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 258 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317
Query: 277 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 318 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375
Query: 337 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 376 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435
Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 436 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493
Query: 450 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 494 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551
Query: 508 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 552 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611
Query: 558 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 612 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662
Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 663 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722
Query: 676 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 723 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782
Query: 736 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 783 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842
Query: 796 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 843 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902
Query: 856 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 903 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 962
Query: 916 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 963 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1022
Query: 976 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 1023 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1082
Query: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1083 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 1143 bits (2956), Expect = 0.0
Identities = 629/1093 (57%), Positives = 781/1093 (71%), Gaps = 57/1093 (5%)
Query: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
Query: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVE 119
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK QQE+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Query: 120 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 179
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
Query: 180 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 239
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Query: 240 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 299
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
Query: 300 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 359
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
Query: 360 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 417
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
Query: 418 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 474
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
Query: 475 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 528
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
Query: 529 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 580
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
Query: 581 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 638
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
Query: 639 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 698
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
Query: 699 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 758
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
Query: 759 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 818
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
Query: 819 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 878
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895
Query: 879 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 938
GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+
Sbjct: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955
Query: 939 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 998
LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV
Sbjct: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015
Query: 999 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1056
S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ +
Sbjct: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071
Query: 1057 RTAGEPMEEEPAL 1069
R EPMEEEP L
Sbjct: 1072 RPDEEPMEEEPPL 1084
>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
Length = 590
Score = 1121 bits (2899), Expect = 0.0
Identities = 574/577 (99%), Positives = 574/577 (99%), Gaps = 3/577 (0%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
Query: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
Query: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
Query: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
Query: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
Query: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
Query: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
Query: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
Query: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 577
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ
Sbjct: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 674 bits (1738), Expect = 0.0
Identities = 450/1018 (44%), Positives = 568/1018 (55%), Gaps = 123/1018 (12%)
Query: 83 LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
LQ +L L QQ+ + +L E++ +EQ+L L KD+ + AVA
Sbjct: 61 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
Query: 143 STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199
S+ VKQKL E +L K + N L A + L PP+
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177
Query: 200 PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259
+LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + S ++
Sbjct: 178 -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227
Query: 260 RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQRILIHE 316
R E S SSS+P SG SSPN+ G P P + + QR+ + E
Sbjct: 228 RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQRLRLQE 276
Query: 317 DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP---------L 367
S+ +L T LP ITLGLPA P++ ++ L G P L
Sbjct: 277 TSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLFLPHGL 333
Query: 368 PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPL 427
+ GG++P S P + L+ P+ SH LL L G +P H L
Sbjct: 334 EPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSL 377
Query: 428 ATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHM 487
T ER+S H PL+RT+S PLP S A Q LE+ K + Q
Sbjct: 378 MTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ---- 425
Query: 488 NKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGA 547
++ +S + ++P + E+L+ D VDD L
Sbjct: 426 --VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH--- 465
Query: 548 VKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHR 607
+E E ++ Q +Q L R S L + G HR
Sbjct: 466 ---RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HR 518
Query: 608 LVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNST 655
+SR SSPAA P PA + S TG+ YD +MLKHQC CG+++
Sbjct: 519 PLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNS 578
Query: 656 THPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKL 715
HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KL
Sbjct: 579 RHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKL 638
Query: 716 DPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKN 775
D L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKN
Sbjct: 639 DNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKN 698
Query: 776 GFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFY 835
GFAVVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY
Sbjct: 699 GFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFY 758
Query: 836 ADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFR 895
DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR
Sbjct: 759 QDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFR 818
Query: 896 TIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLAL 955
+V P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLAL
Sbjct: 819 IVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLAL 878
Query: 956 EGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVR 1015
EGGHDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++
Sbjct: 879 EGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 938
Query: 1016 MVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067
+A VPR + GA +EE E V+ALASL+V + ED + EEEP
Sbjct: 939 RLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 988
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 652 bits (1683), Expect = 0.0
Identities = 440/1010 (43%), Positives = 549/1010 (54%), Gaps = 144/1010 (14%)
Query: 83 LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
LQ +L L QQ+ + +L E++ +EQ+L L KD+ + AVA
Sbjct: 61 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
Query: 143 STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199
S+ VKQKL E +L K + N L A + L PP+
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177
Query: 200 PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259
+LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + S ++
Sbjct: 178 -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227
Query: 260 RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHED 317
R E S SSS+P SG SSPN+ G P P R
Sbjct: 228 RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR------ 270
Query: 318 SMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSI 375
T P+L LG P P L L + GG++
Sbjct: 271 -------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPEAGGTL 304
Query: 376 PASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISP 435
P S P + L+ P+ SH LL L G +P H L T ER+S
Sbjct: 305 P-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTTERLSG 348
Query: 436 GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 495
H PL+RT+S PLP S A Q LE+ K + Q ++ +S
Sbjct: 349 S-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------VIKRSA 394
Query: 496 EQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPV 555
+ ++P + E+L+ D VDD L +E
Sbjct: 395 KPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------RELGH 433
Query: 556 DSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
E ++ Q +Q L R S L + G HR +SR SS
Sbjct: 434 GQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLSRAQSS 489
Query: 616 PAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHPEHAGR 663
PAA P PA + S TG+ YD +MLKHQC CG+++ HPEHAGR
Sbjct: 490 PAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGR 549
Query: 664 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 723
IQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KLD L G
Sbjct: 550 IQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGL 609
Query: 724 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 783
+Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFAVVRPP
Sbjct: 610 LAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPP 669
Query: 784 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 843
GHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY DPS+LYI
Sbjct: 670 GHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYI 729
Query: 844 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903
SLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V P+A+
Sbjct: 730 SLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 789
Query: 904 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 963
EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLALEGGHDLTA
Sbjct: 790 EFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTA 849
Query: 964 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA----- 1018
ICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++ +A
Sbjct: 850 ICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDS 909
Query: 1019 -VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067
VPR + GA +EE E V+ALASL+V + ED + EEEP
Sbjct: 910 WVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 282 bits (722), Expect = 1e-75
Identities = 169/408 (41%), Positives = 234/408 (57%), Gaps = 39/408 (9%)
Query: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
P +L P + S TG+ YD M+ H C +S HPE RI I RL+E G
Sbjct: 467 PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518
Query: 676 LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 734
L +C + R A+ E+ HS E+ L T + ++L +S F S C
Sbjct: 519 LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572
Query: 735 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 794
+ A++A G L V SGE+ NG AVVRPPGHHAE+ A G
Sbjct: 573 PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619
Query: 795 FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 853
FCFFNSVA+ A++ + + +ILIVD DVHHGNGTQ F DPS+LY+SLHRYD G F
Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679
Query: 854 FP--GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVL 911
FP GA +++G G G+ +N+AW G P MGD +YL A+ +V P+A EF+P++VL
Sbjct: 680 FPMGDEGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVL 736
Query: 912 VSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEAC 971
VSAGFDA G PLGG +V+ + + HLT LM LA GR++L LEGG++LT+I ++ AC
Sbjct: 737 VSAGFDAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAAC 794
Query: 972 VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAV 1019
+LLG +P L + P A+ S+ + I++ +YW+S+R++ V
Sbjct: 795 TRSLLG---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV 839
Score = 236 bits (603), Expect = 7e-62
Identities = 143/382 (37%), Positives = 212/382 (55%), Gaps = 32/382 (8%)
Query: 634 SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 693
+ TG+ D + + C+ +S PE R+ +I +L + GLL++C Q R A EE+
Sbjct: 84 AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141
Query: 694 QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 752
LVHS E+ L+ T ++ +L R+L D+++ +S
Sbjct: 142 MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182
Query: 753 AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 812
A +A G V+ L V E++NG A++RPPGHHA+ S G+C FN VA+ A+Y + +
Sbjct: 183 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242
Query: 813 NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEG 870
I ++LIVD DVHHG GTQ F DPS+LY S+HRY++G F+P A N G G G+G
Sbjct: 243 RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQG 302
Query: 871 YNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYK 930
Y IN+ W M D +Y+ AF ++ PVA EF P +VLV+AGFDAL+G P G
Sbjct: 303 YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMA 357
Query: 931 VTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQ 990
T F LT LM LA G+++L+LEGG++L A+ + A ++ LLG+ P+ E
Sbjct: 358 ATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPC-PMLES--PG 414
Query: 991 SPNMNAVISLQKIIEIQSKYWK 1012
+P +A S+ +E +W+
Sbjct: 415 APCRSAQASVSCALEALEPFWE 436
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 236 bits (601), Expect = 1e-61
Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%)
Query: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
Query: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932
+N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
Query: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
Query: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 202 bits (514), Expect = 1e-51
Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%)
Query: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
Query: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932
+N+ W MG+ +Y+ AF ++ P+A E G + T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
Query: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
Query: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 316 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 111 bits (278), Expect = 3e-24
Identities = 105/384 (27%), Positives = 168/384 (43%), Gaps = 61/384 (15%)
Query: 657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 712
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
Query: 713 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
K R +G+D F F L GG V N + A A G
Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234
Query: 768 VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 827
HHA++S A GFC+ N + + L ++L +D+D+HHG
Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275
Query: 828 NGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGD 887
+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D D
Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329
Query: 888 VEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLA 947
Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + +
Sbjct: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVVK 384
Query: 948 DGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP-N 993
+ L + GG T A C E V + + NEL E D LH SP N
Sbjct: 385 TFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN 444
Query: 994 MNAVISLQKIIEIQSKYWKSVRMV 1017
M + + + +I+ + ++++RM+
Sbjct: 445 MTNQNTPEYMEKIKQRLFENLRML 468
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 110 bits (275), Expect = 7e-24
Identities = 105/385 (27%), Positives = 170/385 (44%), Gaps = 63/385 (16%)
Query: 657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 712
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87
Query: 713 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
K R +G+D F F L GG +AS
Sbjct: 88 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121
Query: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 826
V + + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 122 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179
Query: 827 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 886
G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D
Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID---- 233
Query: 887 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 946
D Y F+ ++ V + F P V++ G D+L G LG + +T K GH K + +
Sbjct: 234 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR--LGCFNLTIK--GH-AKCVEFV 288
Query: 947 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 992
+ + + GG T A C E V + + NEL E D LH SP
Sbjct: 289 KSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPS 348
Query: 993 NMNAVISLQKIIEIQSKYWKSVRMV 1017
NM + + + +I+ + ++++RM+
Sbjct: 349 NMTNQNTNEYLEKIKQRLFENLRML 373
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 107 bits (268), Expect = 5e-23
Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%)
Query: 626 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 682
M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L +
Sbjct: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56
Query: 683 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 740
++ + AS+EE+ H++ + Q L GDD GLG D
Sbjct: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103
Query: 741 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 798
++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+
Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155
Query: 799 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 858
N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G
Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212
Query: 859 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 918
++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D
Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268
Query: 919 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 978
+ G P+ + +T G K ++ ++L GG++L +LG
Sbjct: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325
Query: 979 EL 980
L
Sbjct: 326 TL 327
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 89.7 bits (221), Expect = 1e-17
Identities = 47/136 (34%), Positives = 74/136 (54%), Gaps = 9/136 (6%)
Query: 785 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 844
HHA++ A GFC+ N + I L ++L +D+D+HHG+G Q+AFY ++ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191
Query: 845 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903
H+Y GN FFPG+G EVG G Y +N+ G+D D Y F+ ++ V
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245
Query: 904 EFDPDMVLVSAGFDAL 919
+ P +++ G D+L
Sbjct: 246 FYQPTCIVLQCGADSL 261
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 67.4 bits (163), Expect = 7e-11
Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 709
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
Query: 710 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
++ P I L + +K L R G I +A K
Sbjct: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
Query: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 825
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
Query: 826 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 885
GNG ++ F D + + ++ + +PG + + + W G +
Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230
Query: 886 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 945
D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + +
Sbjct: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287
Query: 946 LADGR---VVLALEGGH 959
+ GR +++ GG+
Sbjct: 288 MVRGRRVPILMVTSGGY 304
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 67.4 bits (163), Expect = 7e-11
Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)
Query: 652 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 711
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
Query: 712 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 771
+ L P R G I +A K+A
Sbjct: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
Query: 772 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 829
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
Query: 830 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 889
++ F D + + ++ + +PG + + + W G + D E
Sbjct: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182
Query: 890 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 949
YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G
Sbjct: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240
Query: 950 R---VVLALEGGH 959
R +++ GG+
Sbjct: 241 RRVPILMVTSGGY 253
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/114 (38%), Positives = 68/114 (59%), Gaps = 7/114 (6%)
Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ-ELLAIKQQQELL 103
Q QQ+LLL+QQQ Q+Q+QLL + + + L Q QAQLQ+ + LQQ E L +QQQ+LL
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295
Query: 104 EKEQKLEQQRQ------EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151
+++Q+ QQ+Q E E E + +P G ++ E+ E +Q+L+
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELE 349
Score = 58.2 bits (139), Expect = 4e-08
Identities = 38/93 (40%), Positives = 65/93 (69%), Gaps = 7/93 (7%)
Query: 42 REKQLQQELLLIQQQQ-QIQKQLLIAEFQKQ-HENLTRQHQAQLQEHIKLQQELLAIKQQ 99
+++QLQQ+ QQ+Q Q Q+QLL+ + Q Q + L +Q QAQLQ+ + QQ+ A QQ
Sbjct: 219 QQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQ--AQLQQ 276
Query: 100 QELLEKEQKLEQQRQEQEVERHR---REQQLPP 129
Q LL+++++L+QQ+Q+Q +++ + ++QQL P
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQP 309
Score = 57.8 bits (138), Expect = 5e-08
Identities = 40/100 (40%), Positives = 65/100 (65%), Gaps = 15/100 (15%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAE--------FQKQHENLTRQHQ-AQLQEHIKLQQEL 93
++Q+Q++ LL QQQ+Q+Q+Q L+ + FQ+Q E L +Q Q LQ+ +LQQ+L
Sbjct: 195 QQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQL 254
Query: 94 LAIKQ---QQELLEKEQKLEQQR---QEQEVERHRREQQL 127
L +Q QQ+LLE++Q QQ+ Q+QE + +++QQL
Sbjct: 255 LQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQL 294
Score = 57.0 bits (136), Expect = 9e-08
Identities = 42/102 (41%), Positives = 64/102 (62%), Gaps = 18/102 (17%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKLQQELLAIK 97
++ QLQQ+LL QQQ Q+Q+QLL+ + Q+Q + L +Q Q QLQ+ +LQ L +
Sbjct: 258 QQAQLQQQLLE-QQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQ-QLQPPPLEPE 315
Query: 98 QQQEL--------LEKEQKLEQQRQE----QEVERHRREQQL 127
+++E+ L EQ+LEQQRQE QE+ER + ++QL
Sbjct: 316 EEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357
Score = 55.8 bits (133), Expect = 2e-07
Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%)
Query: 338 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 393
PAV + + AS +E +++ + Q L Q P P Q PH+ L+ +P
Sbjct: 67 PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125
Query: 394 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453
Q L Q L+++ Q +H Q + P ++ H+ + +P +
Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166
Query: 454 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513
L Q Q Q QQ L++Q+Q QQQ+ +LL + EQL+Q L + +E+LQ
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224
Query: 514 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 573
Q Q+ + + GQ+ ++ + + AQ+Q+ +Q A
Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272
Query: 574 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 608
+QQ L + +Q L + L++ +L
Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/128 (28%), Positives = 80/128 (62%), Gaps = 7/128 (5%)
Query: 33 MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQE 92
+ P + + +++QLQ + +Q+QQ++Q+Q + Q+ E Q Q QLQ+ ++ QQ
Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203
Query: 93 LLAIK---QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149
L + QQQ+LL+++++L+QQ+ +Q+ E+ +++QQL L+ + + +++ + + +
Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQ-- 261
Query: 150 LQEFLLSK 157
LQ+ LL +
Sbjct: 262 LQQQLLEQ 269
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/117 (30%), Positives = 69/117 (58%), Gaps = 10/117 (8%)
Query: 41 VREKQLQQELLLIQQ---QQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIK 97
++ +Q Q++ +L QQ QQQ+Q+Q L+ Q+Q E L +Q Q QE ++ QQ +
Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLL---QQQQEQLQQQQLLQQQEQLQQQQ----FQ 229
Query: 98 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154
QQQE L+++Q+L +Q+ ++++ +QQ L+ + +++A ++ + QE L
Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 30/132 (22%)
Query: 44 KQLQQELLLIQQQQQIQKQLLIA------------------------EFQKQHENLTRQH 79
+Q QQ+ LL QQQ+Q+Q+Q L E ++Q + L RQ
Sbjct: 287 QQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346
Query: 80 QAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139
+ + Q+ +Q L +K Q+EL + EQ+LEQQ +Q++E+ + +L P+ + +E
Sbjct: 347 ELERQQ----EQRQLQLKLQEELQQLEQQLEQQ--QQQLEQQEVQLELTPVELGAQQQEV 400
Query: 140 AVASTEVKQKLQ 151
+ T V+ +LQ
Sbjct: 401 QLELTPVQPELQ 412
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 12/109 (11%)
Query: 47 QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLE 104
QQ+L +QQ+ Q + Q L E Q H+ Q Q Q+QE +LQQ QQE L+
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQ-QVQEQQRLQQ-------QQEQLQ 178
Query: 105 KEQKLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 151
+Q EQQ +Q++++++ +EQQL + + +++ + E Q+ Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 20/111 (18%)
Query: 35 PVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQ-HENLTRQ--------------- 78
P P + Q Q L +QQQ Q Q +++ Q++ H+++ Q
Sbjct: 100 PQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQL 159
Query: 79 --HQAQLQEHIKLQQELLAIK--QQQELLEKEQKLEQQRQEQEVERHRREQ 125
Q Q Q+ ++ QQE L + Q+Q++L+++++L+QQ QEQ++ + ++EQ
Sbjct: 160 QPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQ 210
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/132 (28%), Positives = 69/132 (52%), Gaps = 20/132 (15%)
Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIA-----EFQKQHENLTRQHQAQLQE-------H 86
P RE QLQQ + QQQ Q + L E Q+Q + +Q +QLQ+ H
Sbjct: 84 PGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHH 143
Query: 87 IKLQQELLAIKQQQEL----LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142
+L+ EL + QQQ+L ++++Q+L+QQ+++ + ++ + +Q L + ++ V
Sbjct: 144 QELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQ----QQEQLQQQVQ 199
Query: 143 STEVKQKLQEFL 154
++ Q+ QE L
Sbjct: 200 EQQLLQQQQEQL 211
Score = 35.0 bits (79), Expect = 0.38
Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%)
Query: 396 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 453
Q LQ LL++Q Q Q+LL L Q L +E++ + + L + Q
Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306
Query: 454 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499
P P + ++ +Q +Q LE+Q++ ++Q +L K E+L+
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366
Query: 500 QPGSHLEEAEEELQGDQAMQE 520
Q LE+ +++L+ + E
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387
Score = 32.0 bits (71), Expect = 3.2
Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%)
Query: 396 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 447
Q LLQ +EQ++QQ+L PL P+ + + P G+ + L R +
Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346
Query: 448 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 506
L R Q + QL +Q++ QQ ++ +Q QQQ+ ++ L + +L G+ +
Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398
Query: 507 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 552
E + EL Q +Q + P++G + A + G V V+E
Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445
Score = 30.4 bits (67), Expect = 9.3
Identities = 32/115 (27%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 15 PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74
P LEP ++ +L MPV + E++L+Q+ +++QQ++++Q + Q + +
Sbjct: 309 PPPLEPEEEEEVELEL---MPV--DLGSEQELEQQRQELERQQELERQQEQRQLQLKLQE 363
Query: 75 LTRQHQAQL--QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQL 127
+Q + QL Q+ QQE+ Q EL E +QQ + E+ + E QL
Sbjct: 364 ELQQLEQQLEQQQQQLEQQEV-----QLELTPVELGAQQQEVQLELTPVQPELQL 413
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 62.8 bits (151), Expect = 2e-09
Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 63/373 (16%)
Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87
M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q Q +
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194
Query: 88 KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
+QQ+ A+ QQQ+ L+++Q KL Q Q+Q ++ ++ Q++ L+ + + +++
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254
Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199
+ +Q LQ + P + ++ + + + HH Q PP++
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314
Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255
PS T P A+ P + ++P LK R V + P ++++ V T
Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372
Query: 256 SFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVS 308
+ +M +V++SS +SS SPG +P + +PP P
Sbjct: 373 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS-------------MPPPPQPSPQPG 419
Query: 309 QQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ--GVP 366
Q +S N++ G PS S S + Q T Q VP
Sbjct: 420 QP---------------SSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVP 464
Query: 367 LPGQYGGSIPASS 379
PG + SS
Sbjct: 465 SPGPLNTPVNPSS 477
Score = 40.4 bits (93), Expect = 0.009
Identities = 85/436 (19%), Positives = 157/436 (36%), Gaps = 76/436 (17%)
Query: 84 QEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAS 143
Q ++LQQ L +QQQ+ +++Q+ Q+Q+Q+ ++ + + Q ++ + + +
Sbjct: 150 QTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQ 209
Query: 144 TEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYK 203
+ +Q+ Q+ L+ + + R +L L Q +
Sbjct: 210 LQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQ 261
Query: 204 YTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFE 263
L AQ P+++ P+ + +L+Q + P
Sbjct: 262 QALQ-AQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQP------------------- 301
Query: 264 VTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLS 323
P P P V +N+ S LPP + +VSQ + L +
Sbjct: 302 --------------PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------M 338
Query: 324 LYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSH 381
LYT P L + P V Q ++++Q + PG S+P SS
Sbjct: 339 LYTQPPLKFVRA--PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS- 395
Query: 382 PHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISP 435
P + + P S + Q V+ G P S P ++ ++
Sbjct: 396 PSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTA 455
Query: 436 GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKS 494
+P PLN + P S ++ Q + QQ+L+K KQ LSK
Sbjct: 456 RTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKY 502
Query: 495 IEQLKQPGSHLEEAEE 510
IE L++ + +++ E+
Sbjct: 503 IEPLRRMINKIDKNED 518
Score = 37.0 bits (84), Expect = 0.100
Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493
GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ +
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191
Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553
++Q + + +++LQ Q Q+ + + L ++ ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249
Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613
+ Q Q+ Q Q P +P + P A+ + H ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299
Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652
P P A ++P L P S T PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 58.5 bits (140), Expect = 3e-08
Identities = 46/182 (25%), Positives = 91/182 (50%), Gaps = 4/182 (2%)
Query: 23 PLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQ 80
PL + + MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + ++ Q
Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143
Query: 81 AQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
QL + LQQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK ++
Sbjct: 144 EQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQ 202
Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTS 199
+ + Q+ + + + + H +S + L +L S P +G S
Sbjct: 203 QQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLS 262
Query: 200 PS 201
P+
Sbjct: 263 PA 264
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)
Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486
+ T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H
Sbjct: 93 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147
Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546
+ L + +Q +Q ++ +++ Q Q Q+ + A Q
Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207
Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604
++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++
Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267
Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
+ + V+ HS + H +D S+T + P + H V G S+
Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 58.2 bits (139), Expect = 4e-08
Identities = 63/259 (24%), Positives = 114/259 (44%), Gaps = 21/259 (8%)
Query: 43 EKQLQQELLLIQQQQQ-----IQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKLQQELLAI 96
E L+++ L +QQ+ + +++Q L+ E Q ++ E RQ A+ Q+ I+ Q+E
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR 408
Query: 97 KQQQELLEKEQKLEQQRQE--QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 154
++Q+ E+E + +Q+R++ +E E RR ++L R ++ R RA ++ QE++
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468
Query: 155 LSKSATKDTPTNGKNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ 210
+ + + + + + H Q PP S PS+ P A
Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAH 528
Query: 211 ----DAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVT 265
D + P+R T+ P L R Q ++ S R N +S + R ++E
Sbjct: 529 YEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERV 584
Query: 266 ESSVSSSSPGSGPSSPNNG 284
E V GS S N+G
Sbjct: 585 EKLVPRPGSGSSSGSSNSG 603
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 57.8 bits (138), Expect = 5e-08
Identities = 108/497 (21%), Positives = 192/497 (38%), Gaps = 99/497 (19%)
Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ------EHI 87
M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q Q +
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQQQQQQFQAQQS 194
Query: 88 KLQQELLAIKQQQELLEKEQ-------KLEQQRQEQEVERHRREQQLPPLRGKDRGRERA 140
+QQ+ A+ QQQ+ L+++Q KL Q Q+Q ++ ++ Q++ L+ + + +++
Sbjct: 195 AMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQ 254
Query: 141 VASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQ-SSPPLSGTS 199
+ +Q LQ + P + ++ + + + HH Q PP++
Sbjct: 255 QQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQ 314
Query: 200 PS----YKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVT 255
PS T P A+ P + ++P LK R V + P ++++ V T
Sbjct: 315 PSQLPPQSQTQPLVSQAQ-ALPGQMLYTQPPLKF-VRAPMVVQQPPVQPQVQQQQTAVQT 372
Query: 256 SFKKRMFEVTESSVSSS-SPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILI 314
+ +M ++ + + G PT +V+ +S +P VSQ
Sbjct: 373 AQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQS---- 428
Query: 315 HEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGS 374
SLP L P+ Q+ S+ Q P PGQ
Sbjct: 429 --------------SLP--MLSSPSPGQQVQTPQSMPPPP--------QPSPQPGQ---- 460
Query: 375 IPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERIS 434
P+S + +V+ P SS L SP ++ ++
Sbjct: 461 -PSSQPNSNVSSGPAPSPSSF-------------------------LPSPSPQPSQSPVT 494
Query: 435 PGIRGTHKLPRHRPLNRTQSAPLPQSTLAQL-VIQQQHQQFLEKQKQYQQQIHMNKLLSK 493
+P PLN + P S ++ Q + QQ+L+K KQ LSK
Sbjct: 495 ARTPQNFSVPSPGPLNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSK 541
Query: 494 SIEQLKQPGSHLEEAEE 510
IE L++ + +++ E+
Sbjct: 542 YIEPLRRMINKIDKNED 558
Score = 37.0 bits (84), Expect = 0.100
Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 439 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 493
GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ +
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191
Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 553
++Q + + +++LQ Q Q+ + + L ++ ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249
Query: 554 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 613
+ Q Q+ Q Q P +P + P A+ + H ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299
Query: 614 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 652
P P A ++P L P S T PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 55.5 bits (132), Expect = 3e-07
Identities = 46/168 (27%), Positives = 81/168 (48%), Gaps = 7/168 (4%)
Query: 42 REKQLQQELLLIQQQQQ-IQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQ 100
+++QLQQ+ L QQQQQ +Q+Q + + Q Q + +Q Q Q Q+ ++ QQ+ L +QQQ
Sbjct: 3902 QQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQ 3961
Query: 101 ELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT 160
+ +Q+ +QQ+Q+Q++ + + L L + + +++ + K + S A
Sbjct: 3962 Q----QQQFQQQQQQQQMGLLNQSRTL--LSPQQQQQQQVALGPGMPAKPLQHFSSPGAL 4015
Query: 161 KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 208
T + P + A S Q P GT+P T PG
Sbjct: 4016 GPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063
Score = 43.1 bits (100), Expect = 0.001
Identities = 139/663 (20%), Positives = 236/663 (35%), Gaps = 140/663 (21%)
Query: 43 EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQE 101
E ++ L+ +QQ +IQKQL + + QK+H NL +++ KQQQ+
Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN---------------KQQQQ 3602
Query: 102 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATK 161
+Q+ +QQ+Q+ Q P L K G+ + Q +
Sbjct: 3603 ----QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLR 3656
Query: 162 DTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKT 221
TP P L A S S PS + PG + P +
Sbjct: 3657 LTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRL 3715
Query: 222 ASEPNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG 277
E L++ R +L QK+ +++ ++ G V +++ +++ + G
Sbjct: 3716 LQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQG 3775
Query: 278 ---PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRIL 313
PSS P GP G + + +VL P PH + +++Q R+L
Sbjct: 3776 LMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL 3835
Query: 314 IHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGG 373
+SP L GL + +L + +++Q+ + Q G+ Q
Sbjct: 3836 ------------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ--- 3878
Query: 374 SIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERI 433
S+ + S P L +P S Q Q L ++Q QQ+ Q L ++++
Sbjct: 3879 SLMSHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL 3926
Query: 434 SPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSK 493
Q L Q Q + QQQ QQ ++Q+Q QQQ + +
Sbjct: 3927 -------------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQ 3967
Query: 494 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVK 549
+Q +Q G L ++ L Q Q+ A G + S + TL G +
Sbjct: 3968 QQQQQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQ 4026
Query: 550 VKEEPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTH 584
+P S E +++ SG+ + QP +P
Sbjct: 4027 NTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQP 4086
Query: 585 T--------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPG 633
+ R +Q ++ + G H + SS A+SV L P++ QPG
Sbjct: 4087 SSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPG 4146
Query: 634 SAT 636
S T
Sbjct: 4147 SMT 4149
Score = 42.4 bits (98), Expect = 0.002
Identities = 105/460 (22%), Positives = 169/460 (36%), Gaps = 115/460 (25%)
Query: 54 QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQ------ 107
QQQQQ Q+Q +A ++L H Q + + L ++QQQ+L +++Q
Sbjct: 3859 QQQQQHQQQGSMAGLSHLQQSLM-SHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQ 3917
Query: 108 ---KLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF----------L 154
+ +QQ Q+Q++++ +++QQL + + +++ + +Q+ Q+F L
Sbjct: 3918 QQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGL 3977
Query: 155 LSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKD 214
L++S T +P + V+ P + P ++ PGA
Sbjct: 3978 LNQSRTLLSPQQQQQQQVALGPGM------------------PAKPLQHFSSPGALG--- 4016
Query: 215 DFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSP 274
P L LL K+ N V + +VSS +
Sbjct: 4017 ----------PTL-----------------LLTGKEQNTV-----------DPAVSSEAT 4038
Query: 275 GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNIT 334
GPS+ GP T E+ P + ++L L+ P ++
Sbjct: 4039 -EGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLL-------LVQPQPQPQPSSLQ 4090
Query: 335 LGLP-AVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYG-GSIPASSSHPHVTLE----- 387
L P +P Q SL G GQ G GS +SS PH+ +
Sbjct: 4091 LQPPLRLPGQQQQQVSLLH---------TAGGGSHGQLGSGSSSEASSVPHLLAQPSVSL 4141
Query: 388 GKPPNSSHQALL--QHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPR 445
G P S Q LL Q +L+ M+ G P P L + + G+ G +P
Sbjct: 4142 GDQPGSMTQNLLGPQQPMLERPMQNN----TGPQPPKPGPVLQSGQ----GLPGVGIMPT 4193
Query: 446 HRPLN-RTQSAPLPQSTLAQLVIQQQHQ-QFLEKQKQYQQ 483
L + Q L L QQQ Q Q L Q+Q QQ
Sbjct: 4194 VGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQ 4233
>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
Length = 740
Score = 55.1 bits (131), Expect = 4e-07
Identities = 45/185 (24%), Positives = 91/185 (49%), Gaps = 4/185 (2%)
Query: 20 PISPLDLRTDLRMMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTR 77
P + + + MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + +
Sbjct: 106 PHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYK 165
Query: 78 QHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 137
+ Q QL + LQQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK
Sbjct: 166 KQQEQLHLQL-LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKE 224
Query: 138 ERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLS 196
++ + + Q+ + + + + H +S + L +L S P +
Sbjct: 225 QQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQA 284
Query: 197 GTSPS 201
G SP+
Sbjct: 285 GLSPA 289
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 28/283 (9%)
Query: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAG--GVPLHPQSPLA--------TKERISPGIRG 439
P +S Q LQ LL + KL + G HP + A T + I+P +
Sbjct: 76 PKSSDKQRPLQELL-----PETKLCICGHSSGDGHPHNTFAVPVSVAMMTPQVITP--QQ 128
Query: 440 THKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 499
++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H+ L + +Q +
Sbjct: 129 MQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLHLQLLQQQQQQQQQ 185
Query: 500 QPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDE 559
Q ++ +++ Q Q Q+ + A Q ++ V +
Sbjct: 186 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQ 245
Query: 560 DAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLEK-HRLVSRTHSSP 616
Q+Q+++ + +Q+ L P AL V+ P A + +++ + V+ HS
Sbjct: 246 LLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSME 305
Query: 617 AASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
+ H +D S+T + P + H V G S+
Sbjct: 306 DNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 347
>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
Length = 623
Score = 54.7 bits (130), Expect = 5e-07
Identities = 44/173 (25%), Positives = 87/173 (50%), Gaps = 4/173 (2%)
Query: 32 MMMP-VVDPVVREKQLQQELLLIQQQQQI-QKQLLIAEFQKQHENLTRQHQAQLQEHIKL 89
MM P V+ P ++ LQQ++L QQ Q + Q+Q + Q+Q + ++ Q QL + L
Sbjct: 1 MMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQL-L 59
Query: 90 QQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK 149
QQ+ +QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK ++ + +
Sbjct: 60 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA 119
Query: 150 LQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPPLSGTSPS 201
Q+ + + + + H +S + L +L S P +G SP+
Sbjct: 120 AQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPA 172
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)
Query: 427 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 486
+ T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H
Sbjct: 1 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 55
Query: 487 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 546
+ L + +Q +Q ++ +++ Q Q Q+ + A Q
Sbjct: 56 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 115
Query: 547 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 604
++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++
Sbjct: 116 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 175
Query: 605 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 655
+ + V+ HS + H +D S+T + P + H V G S+
Sbjct: 176 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 230
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 53.9 bits (128), Expect = 8e-07
Identities = 71/295 (24%), Positives = 121/295 (41%), Gaps = 58/295 (19%)
Query: 41 VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-----QAQLQEHIKLQQELLA 95
+R +QL QE L +Q++ K+ L+AE QK+ E Q Q + + + QQE
Sbjct: 370 LRRQQLLQEQQLREQEEY--KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQ 427
Query: 96 IKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLL 155
+++QE + ++LE++R+E+E R E++ R ++ R + + LQ+ LL
Sbjct: 428 RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLL 487
Query: 156 SKSA--------------TKDTPTNGKNHSVSRH---PKLWYTAA-------------HH 185
+ A + P + S H PK Y A +H
Sbjct: 488 QEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNH 547
Query: 186 TSLDQSS--------PPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKV 237
+S + S PP+ S S+ +++ P + +EP + VR+ + V
Sbjct: 548 SSPEAQSKQTGRVLEPPVPSRSESF-----SNGNSESVHPALQRPAEPQVPVRTTSRSPV 602
Query: 238 AERRSSPL-------LRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGPSSPNNG 284
RR SPL + N +S + R ++E E V GS S N+G
Sbjct: 603 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSG 657
>gi|41152097 DNA segment on chromosome X and Y (unique) 155
expressed sequence isoform 1 [Homo sapiens]
Length = 695
Score = 53.5 bits (127), Expect = 1e-06
Identities = 44/151 (29%), Positives = 80/151 (52%), Gaps = 23/151 (15%)
Query: 37 VDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQ----- 91
++ + RE++ +++L ++++Q Q+ + QK+ E L + Q QLQE IKL++
Sbjct: 309 LEELERERKREEKL---RKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLL 365
Query: 92 ------------ELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 139
ELL+ + +L E+EQK E+ R +Q+ ER R ++ LR + +ER
Sbjct: 366 AQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQE--AELRRVEEEKER 423
Query: 140 AVASTEVKQKLQEFLLSKSATKDTPTNGKNH 170
A+ +++L+E LLS +K P + H
Sbjct: 424 ALGLQRKERELRERLLSILLSK-KPDDSHTH 453
Score = 35.4 bits (80), Expect = 0.29
Identities = 22/105 (20%), Positives = 64/105 (60%), Gaps = 8/105 (7%)
Query: 55 QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI--KLQQELLAIKQQQELLEKEQKLEQQ 112
+++Q+++Q L Q++ E R+ +A+ ++ + Q+EL ++++++ EK +K EQ+
Sbjct: 269 KKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQK 328
Query: 113 RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 157
++++E+ R++++ + K + E+ ++K + ++ LL++
Sbjct: 329 QRDRELRRNQKKLE------KLQAEEQKQLQEKIKLEERKLLLAQ 367
Score = 32.0 bits (71), Expect = 3.2
Identities = 24/68 (35%), Positives = 39/68 (57%), Gaps = 11/68 (16%)
Query: 95 AIKQQQELLEKEQKLEQQRQEQ-----EVE-----RHRREQQLPPLRGKDRGRERAVAST 144
+IK++Q +K Q+LEQQR+EQ E E R++++L L ++R RE +
Sbjct: 267 SIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELE-RERKREEKLRKR 325
Query: 145 EVKQKLQE 152
E KQ+ +E
Sbjct: 326 EQKQRDRE 333
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 53.1 bits (126), Expect = 1e-06
Identities = 112/559 (20%), Positives = 207/559 (37%), Gaps = 93/559 (16%)
Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQEL 93
MP V P + L QQQQQ Q+Q + Q+Q + +Q Q Q Q I QQ+
Sbjct: 571 MPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQ- 629
Query: 94 LAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK---L 150
+QQQ + +Q+ +QQ+Q+Q+ ++ +++QQ + +++ S + + L
Sbjct: 630 ---QQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPL 686
Query: 151 QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSP-SYKYTLPGA 209
Q+ LL + ++ P G + VS+ + H+ + Q++ P +P S T G
Sbjct: 687 QQKLLLQQ-MQNQPIAGMGYQVSQQQR----QDQHSVVGQNTGPSPSPNPCSNPNTGSGY 741
Query: 210 QDAKDDFPLRKTASEPNLKVRSRLKQKV-----------AER------------RSSPLL 246
+++ ++ + R ++QK AE+ R P
Sbjct: 742 MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDY 801
Query: 247 RRKDGNVVTSFKKRMFEVTESSVSSSS-----------------------------PGSG 277
+ + NV + S++S +S P
Sbjct: 802 KDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLS 861
Query: 278 PSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPN-ITLG 336
+ N G G++ N+ + T Q+ Q+ + LL+ +P +P TLG
Sbjct: 862 TAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQR------NPKQLLANQNNPMMPRPPTLG 915
Query: 337 LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQ 396
PS N + +Q LR L P +S+ +T PN + Q
Sbjct: 916 ----PSNNNNVATFGAGSVGNSQQLRPN--LTHSMASMPPQRTSNVMITSNTTAPNWASQ 969
Query: 397 ALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAP 456
+ +QQ+ L + GV + P T +P + + R + P
Sbjct: 970 --------EGTSKQQEALTSAGV----RFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPP 1017
Query: 457 LPQSTLAQLVIQQQHQQFLEKQKQYQQQ---IHMNKLLSKSIEQLKQPGSHLEEAEEELQ 513
+ Q+ Q Q L Q + + N+L ++ + L Q G+ L ++ +
Sbjct: 1018 NQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGIN 1077
Query: 514 GDQAMQEDRAPSSGNSTRS 532
++ PS S+R+
Sbjct: 1078 QPPSLTPSNFPSPNQSSRA 1096
Score = 42.7 bits (99), Expect = 0.002
Identities = 86/414 (20%), Positives = 142/414 (34%), Gaps = 64/414 (15%)
Query: 262 FEVTESSVSSSSP-GSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMN 320
F + S++S+SSP S P S TGS HA+Q+ ++I +
Sbjct: 391 FSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQL---KQIAANRQQHA 447
Query: 321 LLSLYTSPSLPNITLGLP--AVPSQLNASNSLKEKQKCETQTLR-QGVPLPGQYGGS--- 374
+ + P LP A PS QT Q P+PG GGS
Sbjct: 448 RMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQS 507
Query: 375 -----------IPASSSHPHVTLEGKPPNSSHQALLQ-HLLLKEQMRQQKLLVAGGVPLH 422
A H V ++ KP + S + H ++ + K L H
Sbjct: 508 KVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPL------FH 561
Query: 423 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 482
S A ++ P + + P L+ TQ Q Q QQQ QQ ++Q+Q Q
Sbjct: 562 FNSDQANQQM--PSVLPSQNKPSL--LHYTQQQQQQQQQQQQQ--QQQQQQQQQQQQQQQ 615
Query: 483 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 542
QQ +S +Q +Q ++ +++ Q Q Q+ + + SS
Sbjct: 616 QQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLP 675
Query: 543 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 602
Q + P+ + +Q+M++ P+A +G
Sbjct: 676 SQ----PLLRSPLPLQQKLLLQQMQN------------------------QPIAGMGYQV 707
Query: 603 LEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTT 656
++ R HS + P P+ + P + +G L +Q + G T
Sbjct: 708 SQQQR--QDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQT 759
Score = 37.0 bits (84), Expect = 0.100
Identities = 21/98 (21%), Positives = 52/98 (53%), Gaps = 5/98 (5%)
Query: 55 QQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQ 114
Q Q +L ++ + + T+Q Q Q Q+ + QQ+ QQQ+ +++Q+ +QQ+Q
Sbjct: 566 QANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQQQQQQ 620
Query: 115 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 152
+ + +++QQ + + + +++ + +Q+ Q+
Sbjct: 621 QSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQ 658
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,521,034
Number of Sequences: 37866
Number of extensions: 2255611
Number of successful extensions: 21677
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 651
Number of HSP's that attempted gapping in prelim test: 10395
Number of HSP's gapped (non-prelim): 5864
length of query: 1069
length of database: 18,247,518
effective HSP length: 113
effective length of query: 956
effective length of database: 13,968,660
effective search space: 13354038960
effective search space used: 13354038960
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.