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Search of human proteins with 27886667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27886667 potassium voltage-gated channel, subfamily H,
member 8 [Homo sapiens]
(1107 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27886667 potassium voltage-gated channel, subfamily H, member... 2202 0.0
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 1055 0.0
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 947 0.0
gi|13540549 potassium voltage-gated channel, subfamily H, member... 598 e-171
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 532 e-151
gi|22024390 potassium voltage-gated channel, subfamily H, member... 526 e-149
gi|27437001 potassium voltage-gated channel, subfamily H, member... 522 e-148
gi|27886653 potassium voltage-gated channel, subfamily H, member... 500 e-141
gi|27886646 potassium voltage-gated channel, subfamily H, member... 479 e-135
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 477 e-134
gi|26051273 voltage-gated potassium channel, subfamily H, member... 476 e-134
gi|27886651 potassium voltage-gated channel, subfamily H, member... 476 e-134
gi|27886648 potassium voltage-gated channel, subfamily H, member... 466 e-131
gi|26051271 voltage-gated potassium channel, subfamily H, member... 426 e-119
gi|27886665 potassium voltage-gated channel, subfamily H, member... 350 6e-96
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 160 5e-39
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 159 2e-38
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 157 5e-38
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 154 3e-37
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 154 3e-37
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 153 8e-37
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 151 4e-36
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 143 8e-34
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 140 5e-33
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 133 1e-30
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 97 6e-20
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 92 4e-18
gi|205361107 potassium channel, subfamily K, member 17 isoform 2... 45 3e-04
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ... 45 3e-04
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 41 0.007
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 2202 bits (5707), Expect = 0.0
Identities = 1107/1107 (100%), Positives = 1107/1107 (100%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK
Sbjct: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR 180
GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR 180
Query: 181 REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP 240
REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
Sbjct: 181 REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP 240
Query: 241 YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT 300
YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
Sbjct: 241 YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT 300
Query: 301 TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM 360
TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
Sbjct: 301 TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM 360
Query: 361 SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA 420
SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
Sbjct: 361 SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA 420
Query: 421 YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW 480
YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
Sbjct: 421 YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW 480
Query: 481 SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM 540
SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
Sbjct: 481 SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM 540
Query: 541 HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK 600
HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
Sbjct: 541 HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK 600
Query: 601 DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK 660
DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK
Sbjct: 601 DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK 660
Query: 661 FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE 720
FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE
Sbjct: 661 FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE 720
Query: 721 EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE 780
EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE
Sbjct: 721 EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE 780
Query: 781 IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP 840
IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
Sbjct: 781 IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP 840
Query: 841 RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS 900
RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS
Sbjct: 841 RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS 900
Query: 901 PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS 960
PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS
Sbjct: 901 PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS 960
Query: 961 VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL 1020
VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL
Sbjct: 961 VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL 1020
Query: 1021 TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA 1080
TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA
Sbjct: 1021 TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA 1080
Query: 1081 STKPLENLPLEVVTSTAEVKDNKAINV 1107
STKPLENLPLEVVTSTAEVKDNKAINV
Sbjct: 1081 STKPLENLPLEVVTSTAEVKDNKAINV 1107
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 1055 bits (2728), Expect = 0.0
Identities = 588/1027 (57%), Positives = 703/1027 (68%), Gaps = 59/1027 (5%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPVMKGLLAPQNTFLDTIATRFDGTHSNF+LANAQ +GFPIVYCSDGFCEL G+ RTEV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQK+CSC+FL+G ET+E + ++ K+LE E + EI FY+K+GS FWCLLD++PIKNE
Sbjct: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
Query: 121 GDVVLFLASFKDITDT-KVKITPE----DKKEDKVKGRSRAGTHFDSARRRSRAVLYHIS 175
G+VVLFL SFKDIT + + P+ D + GR A F SARRRSR VL+ ++
Sbjct: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
Query: 176 GHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYV 235
GH RR + +K NNNVF KP+ PEYKV+ S+ +LLH+S KA WD LILLATFYV
Sbjct: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
Query: 236 AVTVPYNVCFIGNDDLS-TTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSI 294
AVTVPYNVCF G+DD T+R T VSDIAVE+LFI+DIILNFRTTYVS+SGQVI RSI
Sbjct: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
Query: 295 CIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI 354
+HY+ TWF IDLIAALPFDLLY FN+TV SLVHLLKTVRLLRLLRLLQKL+RYSQ S +
Sbjct: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
Query: 355 VLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG 414
VLTLLMS+FALLAHWMACIWYVIG+ E E N L W++GWLHELGKRLE PY N ++GG
Sbjct: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYV-NGSVGG 419
Query: 415 PSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQ 474
PS RSAYIAALYFTLSSLTSVGFGNV ANTDAEKIFSICTMLIGALMHA+VFGNVTAIIQ
Sbjct: 420 PSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQ 479
Query: 475 RMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDEL 534
RMYSR SLYH+R KDLKDFIRVH LP+ LKQRMLEYFQTTW+VN+GID+NELL+DFPDEL
Sbjct: 480 RMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDEL 539
Query: 535 RSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSG 594
R+DI MHLN+EILQL LF ASRGCLR+LSLHIKTSFCAPGEYLLR+GDALQA Y+VCSG
Sbjct: 540 RADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSG 599
Query: 595 SMEVLKDSMVLAILGKGDLIGANLSIKDQ----------VIKTNADVKALTYCDLQCIIL 644
S+EVL+D+MVLAILGKGDLIGA++ Q V+KT+ADVKALTYC LQ +
Sbjct: 600 SLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSS 659
Query: 645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNG-NIN 703
+GL EVL LYPEY F + DLT+NLR+G ++ +SR S +SQ + G + +
Sbjct: 660 RGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSD 719
Query: 704 KRLPSIVEDEEEEEEGEEEE------AVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLA 757
K LPSI E E E G +LSP RG SL L
Sbjct: 720 KTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRG-----------------SLVSLL 762
Query: 758 SGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKE---------KNLKLQLSTLNNAGPPD 808
+P S + S S SP + H+ K +L + L GPPD
Sbjct: 763 GEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPD 822
Query: 809 LSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRI-SPPLG---DPEIGAAVLFIKAEETK 864
LSPRIVDGIED S+ E+ +F F PR +PP G PE+ + +AEE K
Sbjct: 823 LSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELAS-----EAEEVK 877
Query: 865 QQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQT 924
+++ +LN E++ L QEVSQL +++R+++ LL+ L P + CP
Sbjct: 878 EKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCL 937
Query: 925 RTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNPADSE 984
S P L T + A + + + + + PS + P +P
Sbjct: 938 SPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEA 997
Query: 985 LYHSPSL 991
+PSL
Sbjct: 998 SPPTPSL 1004
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 947 bits (2447), Expect = 0.0
Identities = 524/993 (52%), Positives = 669/993 (67%), Gaps = 66/993 (6%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MP M+GLLAPQNTFLDTIATRFDGTHSNF+L NAQVA FP+VYCSDGFC+L GF+R EV
Sbjct: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQ+ C+C FL+G +T+E + QI K+L+E EFK E++ Y+K+G PFWCLLD++PIKNEK
Sbjct: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTH----FDSARRRSRAVLYHISG 176
G+V LFL S KDI++TK + P+ KE GR R G F++ RRRSRAVLYH+SG
Sbjct: 121 GEVALFLVSHKDISETKNRGGPDRWKETG-GGRRRYGRARSKGFNANRRRSRAVLYHLSG 179
Query: 177 HLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVA 236
HLQ++ K K K+N VF +KP PEYKV+ +KS FILLH +A WD ILLAT YVA
Sbjct: 180 HLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 239
Query: 237 VTVPYNVCFIGNDDLSTTRST-TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSIC 295
VTVPY+VC + S R +V D+AVE+LFI+DI+LNFRTT+VSKSGQV+F +SIC
Sbjct: 240 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSIC 299
Query: 296 IHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355
+HYVTTWF++D+IAALPFDLL+AF V V HLLKTVRLLRLLRLL +LDRYSQ+S +V
Sbjct: 300 LHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV 359
Query: 356 LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYY-------- 407
LTLLM++FALLAHW+AC+W+ IG+ E E + E+GWL EL +RLE+PYY
Sbjct: 360 LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAG 419
Query: 408 GNNT-------------------LGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEK 448
GN++ LGGPS+RSAYI +LYF LSSLTSVGFGNVSANTD EK
Sbjct: 420 GNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEK 479
Query: 449 IFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRML 508
IFSICTMLIGALMHA+VFGNVTAIIQRMY+R LYH+RT+DL+D+IR+H +P+ LKQRML
Sbjct: 480 IFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRML 539
Query: 509 EYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIK 568
EYFQ TW+VNNGID+ ELL+ PDELR+DI MHL+KE+LQL LFE ASRGCLR+LSL ++
Sbjct: 540 EYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALR 599
Query: 569 TSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTN 628
+FC PGEYL+ QGDALQA+YFVCSGSMEVLK VLAILGKGDLIG L ++QV+K N
Sbjct: 600 PAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKAN 659
Query: 629 ADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNK 688
ADVK LTYC LQC+ L GL + L LYPE+A +F ++ +L+YNL G S
Sbjct: 660 ADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGS--------- 710
Query: 689 SMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAY 748
+ V S G+ + L EE+E +GE+ VS +P S + S+ +
Sbjct: 711 AEVDTSSLSGDNTLMSTL------EEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSA 764
Query: 749 LGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPD 808
L + + R R+ + K + P+ R + L+L N PPD
Sbjct: 765 AKLLSPRRTAPRPRLGGRGRPGRAGALKAEAG---PSAPPRALEGLRLPPMPWNV--PPD 819
Query: 809 LSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETK--QQ 866
LSPR+VDGIEDG S++ + F F + E SP G PE G + E +
Sbjct: 820 LSPRVVDGIEDGCGSDQPK-FSFRVGQSGPECSSSPSPG-PESGLLTVPHGPSEARNTDT 877
Query: 867 INKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRT 926
++KL VT L+++V Q+ + ++++ Q ++ VL+P + CP+ S
Sbjct: 878 LDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTS----- 932
Query: 927 SWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIW 959
QP L + TG ++Y Q + ++ S W
Sbjct: 933 --GLLQP-LCVDTGASSYC-LQPPAGSVLSGTW 961
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 598 bits (1543), Expect = e-171
Identities = 312/722 (43%), Positives = 456/722 (63%), Gaps = 53/722 (7%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNT+LDTI +F+G F++ANAQ+ + I+YC+DGFCEL G++R EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQM-ENCAIIYCNDGFCELFGYSRVEV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQ+ C+C FL G T + ++ ++L E K +I++Y+K+ S F CL+D+VP+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVK--------------------GRSRAGT-- 158
G V++F+ +F+D+ K + + + GR + T
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
Query: 159 ------------HFDSARRRSRAVLYHISGH--LQRREKNKLKINNNVFVDKPAFPEYKV 204
+ + R S + I+ H ++R + K+ + + PEYK+
Sbjct: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
Query: 205 SDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST------- 257
+ ++ +LH+S FKA WDWLILL Y AV PY+ F+ +D + R
Sbjct: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
Query: 258 -TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLL 316
TV D+ V+I+F++DI++NFRTTYV+ + +V+ R I +HY WF+ID++AA+PFDLL
Sbjct: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
Query: 317 Y--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIW 374
+ +L+ LLKT RLLRL+R+ +KLDRYS++ VL LLM FAL+AHW+ACIW
Sbjct: 360 IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIW 419
Query: 375 YVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTS 434
Y IG +ER L+ ++GWL LG +L Y G++ GPS++ Y+ ALYFT SSLTS
Sbjct: 420 YAIGNVERP---YLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
Query: 435 VGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFI 494
VGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS + YHT+ +K+FI
Sbjct: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
Query: 495 RVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-LSLFE 553
R H +P L+QR+ EYFQ WS NGID N +LK FP+ L++DI +HL++ +LQ F
Sbjct: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
Query: 554 CASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDL 613
A +GCLR+L++ KT+ PG+ L+ GD L +YF+ GS+E+L+D +V+AILGK D+
Sbjct: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDI 656
Query: 614 IGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673
G +S+ Q K++ADV+ALTYCDL I L EVLD+YP +A F + ++T+NL
Sbjct: 657 FGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKL--EVTFNL 714
Query: 674 RE 675
R+
Sbjct: 715 RD 716
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 532 bits (1371), Expect = e-151
Identities = 286/688 (41%), Positives = 438/688 (63%), Gaps = 36/688 (5%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64
+GL+APQNTFL+ I R + T NF+L NAQ+ +PIVY +DGFC+L+G+ R EVMQKS
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124
+C F++G T++ + ++ ++ E EI+ YKKN +P W + I PI+NE+ VV
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREK- 183
LFL +F DIT K I ++D KG + A SR VL ++ +Q+ E
Sbjct: 125 LFLCTFSDITAFKQPI-----EDDSCKGWGKFA-RLTRALTSSRGVLQQLAPSVQKGENV 178
Query: 184 -NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYN 242
++ + + P+YK K I+LH+ FK WDW+IL+ TFY A+ VPYN
Sbjct: 179 HKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYN 238
Query: 243 VCFIGNDDLSTTRSTTVS----DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
V F TR V+ D V+++F++DI+LNF TT+V +G+VI + + I ++Y
Sbjct: 239 VSF-------KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY 291
Query: 299 VTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355
+ TWF+IDL++ LP+D++ AF NV + SL LK VRLLRL R+ +KLD Y ++ V
Sbjct: 292 LKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAV 351
Query: 356 LTLLMSMFALLAHWMACIWYVIGKME--REDNSLLKWEVGWLHELGKRLESPYYGNNT-- 411
L LL+ +F L AHWMACIWY IG E ED ++ WL++L + +PY N +
Sbjct: 352 LVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR-NNSWLYQLAMDIGTPYQFNGSGS 410
Query: 412 ---LGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGN 468
GGPS S YI++LYFT++SLTSVGFGN++ +TD EKIF++ M+IG+L++A +FGN
Sbjct: 411 GKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGN 470
Query: 469 VTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLK 528
VT I Q+MY+ + YH ++DF++++ +P+ L +R+++Y +TWS++ GID+ ++L+
Sbjct: 471 VTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQ 530
Query: 529 DFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQA 587
P ++R+DI +HLN+++ + F AS GCLR+L++ +T CAPG+ + G+++ +
Sbjct: 531 ICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDS 590
Query: 588 IYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGL 647
+ FV SGS+EV++D V+AILGKGD+ G + + ++ A+V+ALTYCDL I L
Sbjct: 591 LCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDAL 650
Query: 648 FEVLDLYPEYAHKFVEDIQHDLTYNLRE 675
+VL+ Y ++H F ++ LTYNLR+
Sbjct: 651 QKVLEFYTAFSHSFSRNL--ILTYNLRK 676
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 526 bits (1355), Expect = e-149
Identities = 302/813 (37%), Positives = 483/813 (59%), Gaps = 58/813 (7%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64
+GL+APQNTFL+ I R + S+F+L NAQ+ +P+VY +DGFC+L+G+ R +VMQKS
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124
+C F++G T+++ + ++ ++ + E++ YKKN +P W + I PI+NE VV
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISG-------H 177
LFL +FKDIT K I ++D KG ++ A SR+VL ++ H
Sbjct: 123 LFLCTFKDITLFKQPI-----EDDSTKGWTKFA-RLTRALTNSRSVLQQLTPMNKTEVVH 176
Query: 178 LQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAV 237
R L++ +++ P+YK K I+LH+ FK WDW+IL+ TFY A+
Sbjct: 177 KHSRLAEVLQLGSDIL------PQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAI 230
Query: 238 TVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297
VPYNV F + + V D V+++F++DI+LNF TT+V G+VI + + I ++
Sbjct: 231 MVPYNVSFKTKQN---NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMN 287
Query: 298 YVTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI 354
Y+ TWF+IDL++ LP+D++ AF NV + SL LK VRLLRL R+ +KLD Y ++
Sbjct: 288 YLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAA 347
Query: 355 VLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV-GWLHELGKRLESPYYGNNTLG 413
VL LL+ +F L+AHW+ACIWY IG E D ++ WL++L + +PY N + G
Sbjct: 348 VLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAG 407
Query: 414 ----GPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNV 469
GPS S Y+++LYFT++SLT++GFGN++ TD EK+FS+ M++G+L++A +FGNV
Sbjct: 408 IWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNV 467
Query: 470 TAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKD 529
T I Q+MY+ + YH +++DF++++ +P+ L +R+++Y +TWS++ GID+ ++L
Sbjct: 468 TTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSI 527
Query: 530 FPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAI 588
P ++R+DI +HLN+++ + F AS GCLR+L++ +T CAPG+ + G+++ A+
Sbjct: 528 CPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDAL 587
Query: 589 YFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLF 648
FV SGS+EV++D V+AILGKGD+ G + + A+V+ALTYCDL I + L
Sbjct: 588 CFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALL 647
Query: 649 EVLDLYPEYAHKFVEDIQHDLTYNLRE--------GHESDVISRLSNKSMVSQSEPKGNG 700
+VLD Y +A+ F ++ LT NLR+ + + RL K+ V+ S P +
Sbjct: 648 KVLDFYTAFANSFSRNL--TLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH- 704
Query: 701 NINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNK-KVGSNKAYLGLSLKQLASG 759
+ K + +E +G T+G RN+ +V S G S+ +
Sbjct: 705 PVRKLFQKFKQQKELRNQGS-----------TQGDPERNQLQVESRSLQNGASITGTSVV 753
Query: 760 TVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEK 792
TV +PI+ S + KT + + N + + K
Sbjct: 754 TVSQITPIQTSLA-YVKTSESLKQNNRDAMELK 785
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 522 bits (1345), Expect = e-148
Identities = 287/715 (40%), Positives = 438/715 (61%), Gaps = 63/715 (8%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64
+GL+APQNTFL+ I R + T NF+L NAQ+ +PIVY +DGFC+L+G+ R EVMQKS
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124
+C F++G T++ + ++ ++ E EI+ YKKN +P W + I PI+NE+ VV
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREK- 183
LFL +F DIT K I ++D KG + A SR VL ++ +Q+ E
Sbjct: 125 LFLCTFSDITAFKQPI-----EDDSCKGWGKF-ARLTRALTSSRGVLQQLAPSVQKGENV 178
Query: 184 -NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYN 242
++ + + P+YK K I+LH+ FK WDW+IL+ TFY A+ VPYN
Sbjct: 179 HKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYN 238
Query: 243 VCFIGNDDLSTTRSTTVS----DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
V F TR V+ D V+++F++DI+LNF TT+V +G+VI + + I ++Y
Sbjct: 239 VSF-------KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY 291
Query: 299 VTTWFIIDLIAALPFDLLYAF-NVTVV-----------------------------SLVH 328
+ TWF+IDL++ LP+D++ AF NV V SL
Sbjct: 292 LKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFS 351
Query: 329 LLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKME--REDNS 386
LK VRLLRL R+ +KLD Y ++ VL LL+ +F L AHWMACIWY IG E ED
Sbjct: 352 SLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTK 411
Query: 387 LLKWEVGWLHELGKRLESPYYGNNT-----LGGPSIRSAYIAALYFTLSSLTSVGFGNVS 441
++ WL++L + +PY N + GGPS S YI++LYFT++SLTSVGFGN++
Sbjct: 412 TIR-NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIA 470
Query: 442 ANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQ 501
+TD EKIF++ M+IG+L++A +FGNVT I Q+MY+ + YH ++DF++++ +P+
Sbjct: 471 PSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPK 530
Query: 502 QLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCL 560
L +R+++Y +TWS++ GID+ ++L+ P ++R+DI +HLN+++ + F AS GCL
Sbjct: 531 GLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCL 590
Query: 561 RSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSI 620
R+L++ +T CAPG+ + G+++ ++ FV SGS+EV++D V+AILGKGD+ G
Sbjct: 591 RALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWK 650
Query: 621 KDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLRE 675
+ + ++ A+V+ALTYCDL I L +VL+ Y ++H F ++ LTYNLR+
Sbjct: 651 EATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNLRK 703
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 500 bits (1287), Expect = e-141
Identities = 300/771 (38%), Positives = 448/771 (58%), Gaps = 57/771 (7%)
Query: 187 KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246
K+ + + PEYK+ + +KF +LH+S FKA WDWLILL Y A+ PY+ F+
Sbjct: 373 KVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFL 432
Query: 247 GNDDLSTTRST--------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
ND R V D+ V+I+FIIDI++NFRTTYV+++ +V+ + I IHY
Sbjct: 433 LNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY 492
Query: 299 VTTWFIIDLIAALPFDLLY--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVL 356
WF+ID++AA+PFDLL + + +L+ LLKT RLLRL+R+ +KLDRYS++ VL
Sbjct: 493 FKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL 552
Query: 357 TLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPS 416
LLM +FAL+AHW+ACIWY IG +ER L ++GWL LG+++ Y +++ GPS
Sbjct: 553 MLLMCIFALIAHWLACIWYAIGNVERP---YLTDKIGWLDSLGQQIGKRYNDSDSSSGPS 609
Query: 417 IRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRM 476
I+ Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+
Sbjct: 610 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 669
Query: 477 YSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRS 536
YS + YH + +K+FIR H +P L+QR+ EYFQ W+ NGID N +LK FP+ L++
Sbjct: 670 YSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQA 729
Query: 537 DITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGS 595
DI +HLN+ +LQ F AS+GCLR+L++ KT+ PG+ L+ GD L A+YF+ GS
Sbjct: 730 DICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGS 789
Query: 596 MEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYP 655
+E+LKD +V+AILGK D+ G + + + K+NADV+ALTYCDL I + L EVLD+YP
Sbjct: 790 IEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYP 849
Query: 656 EYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEE 715
E++ F+ ++ +LT+NLR HES L ++SM ++ +G+ +R E E E
Sbjct: 850 EFSDHFLTNL--ELTFNLR--HESAKADLLRSQSM---NDSEGDNCKLRRRKLSFESEGE 902
Query: 716 EEEGEEEEAVSLSPICTRGSSSRN--KKVGSNKAYLGL---SLKQLASGTVPFHSPI-RV 769
+E + S I SS R+ +K + +++ K L SG V I +
Sbjct: 903 KENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKA 962
Query: 770 SRSNSPKT-----KQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSE 824
S + +T + ID +H+ + +++ + P D SP + G S
Sbjct: 963 SGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISET 1022
Query: 825 ESQ-TFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQ 883
ES T+ +R+ + ++Q+N+L S++TT Q + Q
Sbjct: 1023 ESDLTYGEVEQRL------------------------DLLQEQLNRLESQMTTDIQTILQ 1058
Query: 884 LGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPC 934
L + V+ ++++ + + S++T S+S C
Sbjct: 1059 LLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQC 1109
Score = 143 bits (360), Expect = 1e-33
Identities = 68/143 (47%), Positives = 98/143 (68%), Gaps = 1/143 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNTFL TI +F+G + FI+ANA+V + I+YC+DGFCE+ GF+R +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARV-QNCAIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQK C+C FL G ET + QI ++L E K E+ +Y KNGS F C I+P+KN++
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GDVVLFLASFKDITDTKVKITPE 143
G ++F+ +F+ +TD + TPE
Sbjct: 120 GVAMMFIINFEYVTDNENAATPE 142
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 479 bits (1232), Expect = e-135
Identities = 249/620 (40%), Positives = 397/620 (64%), Gaps = 34/620 (5%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64
+GL+APQNTFL+ I R + S+F+L NAQ+ +P+VY +DGFC+L+G+ R +VMQKS
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124
+C F++G T+++ + ++ ++ + E++ YKKN +P W + I PI+NE VV
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISG-------H 177
LFL +FKDIT K I ++D KG ++ A SR+VL ++ H
Sbjct: 123 LFLCTFKDITLFKQPI-----EDDSTKGWTKFA-RLTRALTNSRSVLQQLTPMNKTEVVH 176
Query: 178 LQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAV 237
R L++ +++ P+YK K I+LH+ FK WDW+IL+ TFY A+
Sbjct: 177 KHSRLAEVLQLGSDIL------PQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAI 230
Query: 238 TVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297
VPYNV F + + V D V+++F++DI+LNF TT+V G+VI + + I ++
Sbjct: 231 MVPYNVSFKTKQN---NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMN 287
Query: 298 YVTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI 354
Y+ TWF+IDL++ LP+D++ AF NV + SL LK VRLLRL R+ +KLD Y ++
Sbjct: 288 YLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAA 347
Query: 355 VLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV-GWLHELGKRLESPYYGNNTLG 413
VL LL+ +F L+AHW+ACIWY IG E D ++ WL++L + +PY N + G
Sbjct: 348 VLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAG 407
Query: 414 ----GPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNV 469
GPS S Y+++LYFT++SLT++GFGN++ TD EK+FS+ M++G+L++A +FGNV
Sbjct: 408 IWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNV 467
Query: 470 TAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKD 529
T I Q+MY+ + YH +++DF++++ +P+ L +R+++Y +TWS++ GID+ ++L
Sbjct: 468 TTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSI 527
Query: 530 FPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAI 588
P ++R+DI +HLN+++ + F AS GCLR+L++ +T CAPG+ + G+++ A+
Sbjct: 528 CPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDAL 587
Query: 589 YFVCSGSMEVLKDSMVLAIL 608
FV SGS+EV++D V+AIL
Sbjct: 588 CFVVSGSLEVIQDDEVVAIL 607
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 477 bits (1228), Expect = e-134
Identities = 291/738 (39%), Positives = 419/738 (56%), Gaps = 52/738 (7%)
Query: 187 KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246
K+ + + PEYK+ + ++ +LH+S FKA WDWLILL Y AV PY+ F+
Sbjct: 373 KVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFL 432
Query: 247 GNDDLSTTRST---------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297
+ +T V D+ V+I+FI+DI++NFRTTYV+ + +V+ I +H
Sbjct: 433 LKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVH 492
Query: 298 YVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLT 357
Y WF+ID++AA+PFDLL F L+ LLKT RLLRL+R+ +KLDRYS++ VL
Sbjct: 493 YFKGWFLIDMVAAIPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 551
Query: 358 LLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSI 417
LLM FAL+AHW+ACIWY IG ME+ + +GWLH LG ++ PY ++ LGGPSI
Sbjct: 552 LLMCTFALIAHWLACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSI 607
Query: 418 RSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMY 477
+ Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+Y
Sbjct: 608 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLY 667
Query: 478 SRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537
S + YHT+ +++FIR H +P L+QR+ EYFQ WS NGID N +LK FP+ L++D
Sbjct: 668 SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 727
Query: 538 ITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSM 596
I +HLN+ +LQ F A++GCLR+L++ KT+ PG+ L+ GD L A+YF+ GS+
Sbjct: 728 ICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSI 787
Query: 597 EVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPE 656
E+L+ +V+AILGK D+ G L++ + K+N DV+ALTYCDL I L EVLD+YPE
Sbjct: 788 EILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
Query: 657 YAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEE 716
++ F + ++T+NLR+ + + S S G KR S +++
Sbjct: 848 FSDHFWSSL--EITFNLRD-------TNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKD 898
Query: 717 EEGEEEEAVSLSPICTRGSSSRNKKVG--SNKAYLGLSLKQLASGTVP--FHSPIRVSRS 772
E E + G SSR + G G S + + P SP+R+
Sbjct: 899 TEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPF 958
Query: 773 NSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVD--GIEDGNSSEESQTFD 830
+SP+ E PP E K + +G I G G +E
Sbjct: 959 SSPRPPGE--PPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCP 1016
Query: 831 FGSERIRSEPRISP---PLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKD 887
+ + + P SP P GD E + + ++Q+N+L ++L D
Sbjct: 1017 APTPSLLNIPLSSPGRRPRGDVE-------SRLDALQRQLNRLE----------TRLSAD 1059
Query: 888 MRNVIQLLENVLSPQQPS 905
M V+QLL+ ++ P+
Sbjct: 1060 MATVLQLLQRQMTLVPPA 1077
Score = 144 bits (362), Expect = 6e-34
Identities = 68/142 (47%), Positives = 99/142 (69%), Gaps = 1/142 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNTFLDTI +F+G FI+ANA+V + ++YC+DGFCEL G++R EV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARV-ENCAVIYCNDGFCELCGYSRAEV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQ+ C+C FL G T + QI ++L E K EI FY+K+GS F CL+D+VP+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GDVVLFLASFKDITDTKVKITP 142
G V++F+ +F+ + + + +P
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSP 141
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 476 bits (1226), Expect = e-134
Identities = 290/725 (40%), Positives = 415/725 (57%), Gaps = 52/725 (7%)
Query: 200 PEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST-- 257
PEYK+ + ++ +LH+S FKA WDWLILL Y AV PY+ F+ + +T
Sbjct: 46 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATEC 105
Query: 258 -------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAA 310
V D+ V+I+FI+DI++NFRTTYV+ + +V+ I +HY WF+ID++AA
Sbjct: 106 GYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAA 165
Query: 311 LPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWM 370
+PFDLL F L+ LLKT RLLRL+R+ +KLDRYS++ VL LLM FAL+AHW+
Sbjct: 166 IPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL 224
Query: 371 ACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLS 430
ACIWY IG ME+ + +GWLH LG ++ PY ++ LGGPSI+ Y+ ALYFT S
Sbjct: 225 ACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSIKDKYVTALYFTFS 280
Query: 431 SLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDL 490
SLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YHT+ +
Sbjct: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340
Query: 491 KDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-L 549
++FIR H +P L+QR+ EYFQ WS NGID N +LK FP+ L++DI +HLN+ +LQ
Sbjct: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400
Query: 550 SLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILG 609
F A++GCLR+L++ KT+ PG+ L+ GD L A+YF+ GS+E+L+ +V+AILG
Sbjct: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460
Query: 610 KGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDL 669
K D+ G L++ + K+N DV+ALTYCDL I L EVLD+YPE++ F + ++
Sbjct: 461 KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EI 518
Query: 670 TYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSP 729
T+NLR+ + + S S G KR S +++ E E +
Sbjct: 519 TFNLRD-------TNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPG 571
Query: 730 ICTRGSSSRNKKVG--SNKAYLGLSLKQLASGTVP--FHSPIRVSRSNSPKTKQEIDPPN 785
G SSR + G G S + + P SP+R+ +SP+ E PP
Sbjct: 572 RAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGE--PPG 629
Query: 786 HNKRKEKNLKLQLSTLNNAGPPDLSPRIVD--GIEDGNSSEESQTFDFGSERIRSEPRIS 843
E K + +G I G G +E + + + P S
Sbjct: 630 GEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSS 689
Query: 844 P---PLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS 900
P P GD E + + ++Q+N+L ++L DM V+QLL+ ++
Sbjct: 690 PGRRPRGDVE-------SRLDALQRQLNRLE----------TRLSADMATVLQLLQRQMT 732
Query: 901 PQQPS 905
P+
Sbjct: 733 LVPPA 737
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 476 bits (1225), Expect = e-134
Identities = 275/722 (38%), Positives = 407/722 (56%), Gaps = 106/722 (14%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNT+LDTI +F+G F++ANAQ+ + I+YC+DGFCEL G++R EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQM-ENCAIIYCNDGFCELFGYSRVEV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQ+ C+C FL G T + ++ ++L E K +I++Y+K+ S F CL+D+VP+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVK--------------------GRSRAGT-- 158
G V++F+ +F+D+ K + + + GR + T
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
Query: 159 ------------HFDSARRRSRAVLYHISGH--LQRREKNKLKINNNVFVDKPAFPEYKV 204
+ + R S + I+ H ++R + K+ + + PEYK+
Sbjct: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
Query: 205 SDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST------- 257
+ ++ +LH+S FKA WDWLILL Y AV PY+ F+ +D + R
Sbjct: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
Query: 258 -TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLL 316
TV D+ V+I+F++DI++NFRTTYV+ + +V+ R I +HY WF+ID++AA+PFDLL
Sbjct: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
Query: 317 Y--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIW 374
+ +L+ LLKT RL LRL++
Sbjct: 360 IFRTGSDETTTLIGLLKTARL---LRLVR------------------------------- 385
Query: 375 YVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTS 434
V K++R YG L A IA + SLTS
Sbjct: 386 -VARKLDRYSE---------------------YGAAVLFLLMCTFALIAHWLACICSLTS 423
Query: 435 VGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFI 494
VGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS + YHT+ +K+FI
Sbjct: 424 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 483
Query: 495 RVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-LSLFE 553
R H +P L+QR+ EYFQ WS NGID N +LK FP+ L++DI +HL++ +LQ F
Sbjct: 484 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 543
Query: 554 CASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDL 613
A +GCLR+L++ KT+ PG+ L+ GD L +YF+ GS+E+L+D +V+AILGK D+
Sbjct: 544 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDI 603
Query: 614 IGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673
G +S+ Q K++ADV+ALTYCDL I L EVLD+YP +A F + ++T+NL
Sbjct: 604 FGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKL--EVTFNL 661
Query: 674 RE 675
R+
Sbjct: 662 RD 663
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 466 bits (1200), Expect = e-131
Identities = 248/631 (39%), Positives = 394/631 (62%), Gaps = 33/631 (5%)
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQKS +C F++G T+++ + ++ ++ + E++ YKKN +P W + I PI+NE
Sbjct: 1 MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISG---- 176
VVLFL +FKDIT K I ++D KG ++ A SR+VL ++
Sbjct: 61 EKVVLFLCTFKDITLFKQPI-----EDDSTKGWTKFA-RLTRALTNSRSVLQQLTPMNKT 114
Query: 177 ---HLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATF 233
H R L++ +++ P+YK K I+LH+ FK WDW+IL+ TF
Sbjct: 115 EVVHKHSRLAEVLQLGSDIL------PQYKQEAPKTPPHIILHYCAFKTTWDWVILILTF 168
Query: 234 YVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARS 293
Y A+ VPYNV F + + V D V+++F++DI+LNF TT+V G+VI + +
Sbjct: 169 YTAIMVPYNVSFKTKQN---NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKL 225
Query: 294 ICIHYVTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQ 350
I ++Y+ TWF+IDL++ LP+D++ AF NV + SL LK VRLLRL R+ +KLD Y +
Sbjct: 226 IRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLE 285
Query: 351 HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV-GWLHELGKRLESPYYGN 409
+ VL LL+ +F L+AHW+ACIWY IG E D ++ WL++L + +PY N
Sbjct: 286 YGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345
Query: 410 NTLG----GPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALV 465
+ G GPS S Y+++LYFT++SLT++GFGN++ TD EK+FS+ M++G+L++A +
Sbjct: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
Query: 466 FGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNE 525
FGNVT I Q+MY+ + YH +++DF++++ +P+ L +R+++Y +TWS++ GID+ +
Sbjct: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465
Query: 526 LLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDA 584
+L P ++R+DI +HLN+++ + F AS GCLR+L++ +T CAPG+ + G++
Sbjct: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525
Query: 585 LQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIIL 644
+ A+ FV SGS+EV++D V+AILGKGD+ G + + A+V+ALTYCDL I
Sbjct: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585
Query: 645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLRE 675
+ L +VLD Y +A+ F ++ LT NLR+
Sbjct: 586 EALLKVLDFYTAFANSFSRNL--TLTCNLRK 614
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 426 bits (1096), Expect = e-119
Identities = 216/444 (48%), Positives = 299/444 (67%), Gaps = 15/444 (3%)
Query: 187 KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246
K+ + + PEYK+ + ++ +LH+S FKA WDWLILL Y AV PY+ F+
Sbjct: 373 KVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFL 432
Query: 247 GNDDLSTTRST---------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297
+ +T V D+ V+I+FI+DI++NFRTTYV+ + +V+ I +H
Sbjct: 433 LKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVH 492
Query: 298 YVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLT 357
Y WF+ID++AA+PFDLL F L+ LLKT RLLRL+R+ +KLDRYS++ VL
Sbjct: 493 YFKGWFLIDMVAAIPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 551
Query: 358 LLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSI 417
LLM FAL+AHW+ACIWY IG ME+ + +GWLH LG ++ PY ++ LGGPSI
Sbjct: 552 LLMCTFALIAHWLACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSI 607
Query: 418 RSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMY 477
+ Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+Y
Sbjct: 608 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLY 667
Query: 478 SRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537
S + YHT+ +++FIR H +P L+QR+ EYFQ WS NGID N +LK FP+ L++D
Sbjct: 668 SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 727
Query: 538 ITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSM 596
I +HLN+ +LQ F A++GCLR+L++ KT+ PG+ L+ GD L A+YF+ GS+
Sbjct: 728 ICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSI 787
Query: 597 EVLKDSMVLAILGKGDLIGANLSI 620
E+L+ +V+AILG G G L +
Sbjct: 788 EILRGDVVVAILGMGWGAGTGLEM 811
Score = 144 bits (362), Expect = 6e-34
Identities = 68/142 (47%), Positives = 99/142 (69%), Gaps = 1/142 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNTFLDTI +F+G FI+ANA+V + ++YC+DGFCEL G++R EV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARV-ENCAVIYCNDGFCELCGYSRAEV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQ+ C+C FL G T + QI ++L E K EI FY+K+GS F CL+D+VP+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GDVVLFLASFKDITDTKVKITP 142
G V++F+ +F+ + + + +P
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSP 141
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 350 bits (897), Expect = 6e-96
Identities = 174/348 (50%), Positives = 238/348 (68%), Gaps = 13/348 (3%)
Query: 187 KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246
K+ + + PEYK+ + +KF +LH+S FKA WDWLILL Y A+ PY+ F+
Sbjct: 366 KVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFL 425
Query: 247 GNDDLSTTRST--------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
ND R V D+ V+I+FIIDI++NFRTTYV+++ +V+ + I IHY
Sbjct: 426 LNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY 485
Query: 299 VTTWFIIDLIAALPFDLLY--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVL 356
WF+ID++AA+PFDLL + + +L+ LLKT RLLRL+R+ +KLDRYS++ VL
Sbjct: 486 FKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL 545
Query: 357 TLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPS 416
LLM +FAL+AHW+ACIWY IG +ER L ++GWL LG+++ Y +++ GPS
Sbjct: 546 MLLMCIFALIAHWLACIWYAIGNVERP---YLTDKIGWLDSLGQQIGKRYNDSDSSSGPS 602
Query: 417 IRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRM 476
I+ Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+
Sbjct: 603 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 662
Query: 477 YSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSN 524
YS + YH + +K+FIR H +P L+QR+ EYFQ W+ NGID N
Sbjct: 663 YSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMN 710
Score = 143 bits (360), Expect = 1e-33
Identities = 68/143 (47%), Positives = 98/143 (68%), Gaps = 1/143 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
MPV +G +APQNTFL TI +F+G + FI+ANA+V + I+YC+DGFCE+ GF+R +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARV-QNCAIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
MQK C+C FL G ET + QI ++L E K E+ +Y KNGS F C I+P+KN++
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GDVVLFLASFKDITDTKVKITPE 143
G ++F+ +F+ +TD + TPE
Sbjct: 120 GVAMMFIINFEYVTDNENAATPE 142
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 160 bits (406), Expect = 5e-39
Identities = 121/529 (22%), Positives = 236/529 (44%), Gaps = 69/529 (13%)
Query: 212 FILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIID 271
+I+ +S F+ WD+ +LL + +P + F ++ TT V ++ + F++D
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDE---TTAPWIVFNVVSDTFFLMD 258
Query: 272 IILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLY------------- 317
++LNFRT V + ++I + I Y+ TWF++D ++++P D ++
Sbjct: 259 LVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
Query: 318 -AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HSTIVLTL-------LMSMFALLA 367
A + +V +L +RLLRL RL++ + ++ + H T L L+SM LL
Sbjct: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
Query: 368 HWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYF 427
HW C+ +++ ++ + + N + S Y AL+
Sbjct: 379 HWDGCLQFLVPMLQDFPRNC------------------WVSINGMVNHSWSELYSFALFK 420
Query: 428 TLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRT 487
+S + +G+G + + + ++ +M++GA +A+ G+ TA+IQ + S Y +
Sbjct: 421 AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 480
Query: 488 KDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDI-TMHLNKEI 546
K ++ ++ H LP +Q++ +Y++ + D + +L + LR +I + K +
Sbjct: 481 KQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLV 539
Query: 547 LQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLA 606
+ LF A + ++ +K PG+Y++R+G + +YF+ G + VL
Sbjct: 540 ASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM 599
Query: 607 ILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKF----- 661
L G G + + A V+A TYC L + + EVL+ YP F
Sbjct: 600 KLSDGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAI 657
Query: 662 -------------VEDIQHDLTYNLREGHESDVISRL--SNKSMVSQSE 695
+ +QHDL + E+ +I + ++ MV Q+E
Sbjct: 658 DRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAE 706
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 159 bits (401), Expect = 2e-38
Identities = 118/522 (22%), Positives = 234/522 (44%), Gaps = 68/522 (13%)
Query: 208 KKSKFILLH-FSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEI 266
K + F ++H +S F+ WD +LL + +P + F +++ T V ++ +
Sbjct: 248 KSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDEN---TTPWIVFNVVSDT 304
Query: 267 LFIIDIILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVT--- 322
F+ID++LNFRT V + ++I + + I + Y+ +WF++D I+++P D ++ T
Sbjct: 305 FFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRID 364
Query: 323 -----------VVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HST-------IVLTLLMSM 362
+V +L +RLLRL RL++ + ++ + H T + + L+ M
Sbjct: 365 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGM 424
Query: 363 FALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYI 422
LL HW C+ +++ ++ + + N + S Y
Sbjct: 425 MLLLCHWDGCLQFLVPMLQDFPDDC------------------WVSINNMVNNSWGKQYS 466
Query: 423 AALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSL 482
AL+ +S + +G+G + ++ ++ +M++GA +A+ G+ TA+IQ + S
Sbjct: 467 YALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526
Query: 483 YHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD-ITMH 541
Y + K ++ ++ H LP +QR+ +Y++ + D +L + + LR + I +
Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585
Query: 542 LNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601
K + + LF A + S+ ++ PG+Y++R+G + +YF+ G + VL
Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645
Query: 602 SMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKF 661
L G G + + A V+A TYC L + + EVL+ YP F
Sbjct: 646 GNKETKLADGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703
Query: 662 ------------------VEDIQHDLTYNLREGHESDVISRL 685
+ +QHDL + E+++I ++
Sbjct: 704 ETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQI 745
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 157 bits (397), Expect = 5e-38
Identities = 113/480 (23%), Positives = 225/480 (46%), Gaps = 50/480 (10%)
Query: 208 KKSKFILLH-FSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEI 266
K + F ++H +S F+ WD ++L+ V +P + F TT + ++A +
Sbjct: 128 KTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQ---TTTPWIIFNVASDT 184
Query: 267 LFIIDIILNFRTTYVSK-SGQVIFEARSICIHYVTTWFIIDLIAALPFDLLY-------- 317
+F++D+I+NFRT V++ S ++I + + I ++Y+ +WF++D I+++P D ++
Sbjct: 185 VFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMD 244
Query: 318 ------AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HSTIVLTL-------LMSM 362
A + +V +L +RLLRL RL++ + ++ + H T L L+ M
Sbjct: 245 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGM 304
Query: 363 FALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYI 422
LL HW C+ +++ ++ + N + S Y
Sbjct: 305 MLLLCHWDGCLQFLVPLLQDFPPDC------------------WVSLNEMVNDSWGKQYS 346
Query: 423 AALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSL 482
AL+ +S + +G+G + + ++ ++ +M++GA +A+ G+ TA+IQ + S
Sbjct: 347 YALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406
Query: 483 YHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDI-TMH 541
Y + K ++ ++ H LP ++Q++ +Y++ + D +L + D LR +I +
Sbjct: 407 YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465
Query: 542 LNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601
K + + LF A + ++ ++ PG+Y++R+G + +YF+ G V+
Sbjct: 466 CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK 525
Query: 602 SMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKF 661
S L G G + + A V+A TYC L + + EVL+ YP F
Sbjct: 526 SSKEMKLTDGSYFGEICLLTKG--RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 154 bits (390), Expect = 3e-37
Identities = 128/549 (23%), Positives = 250/549 (45%), Gaps = 56/549 (10%)
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR 180
G + LF + D + + + KKE K K + D +++ ++
Sbjct: 154 GAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKK------------KK 201
Query: 181 REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP 240
++K K K K + K + KK ++ W + I L Y V
Sbjct: 202 KDKEKKK--------KEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 253
Query: 241 YNVCFIGNDDLSTT--RSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
CF D+L + + D +I+++ID+ + RT Y+ + V E + I +
Sbjct: 254 ARACF---DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYK 310
Query: 299 VTTWFIIDLIAALPFDLLY---AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355
F +D+++ +P DLLY +N + L LL R R+ Q+ + + + I
Sbjct: 311 SNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLL---RFSRMFEFFQRTETRTNYPNIF 367
Query: 356 -LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG 414
++ L+ ++ HW AC++Y I K N W++ + P +G
Sbjct: 368 RISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVYP---DINDPEFGR----- 413
Query: 415 PSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQ 474
+ Y+ +LY++ +LT++G D+E +F + LIG L+ A + GN+ ++I
Sbjct: 414 --LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNIGSMIS 470
Query: 475 RMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDEL 534
M + + + R +K ++ ++ + +++R++++F W+ +D E+LK PD+L
Sbjct: 471 NMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKL 530
Query: 535 RSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCS 593
R++I ++++ + L ++ +F G L L L ++ +PG+Y+ ++GD + +Y +
Sbjct: 531 RAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKE 590
Query: 594 GSMEVLKDSMV--LAILGKGDLIG--ANLSIKDQVI--KTNADVKALTYCDLQCIILKGL 647
G + V+ D V +L G G + L+IK + A++K++ Y DL C+ L
Sbjct: 591 GKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDL 650
Query: 648 FEVLDLYPE 656
E L YP+
Sbjct: 651 MEALTEYPD 659
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 154 bits (390), Expect = 3e-37
Identities = 128/549 (23%), Positives = 250/549 (45%), Gaps = 56/549 (10%)
Query: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR 180
G + LF + D + + + KKE K K + D +++ ++
Sbjct: 85 GAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKK------------KK 132
Query: 181 REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP 240
++K K K K + K + KK ++ W + I L Y V
Sbjct: 133 KDKEKKK--------KEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 184
Query: 241 YNVCFIGNDDLSTT--RSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298
CF D+L + + D +I+++ID+ + RT Y+ + V E + I +
Sbjct: 185 ARACF---DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYK 241
Query: 299 VTTWFIIDLIAALPFDLLY---AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355
F +D+++ +P DLLY +N + L LL R R+ Q+ + + + I
Sbjct: 242 SNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLL---RFSRMFEFFQRTETRTNYPNIF 298
Query: 356 -LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG 414
++ L+ ++ HW AC++Y I K N W++ + P +G
Sbjct: 299 RISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVYP---DINDPEFGR----- 344
Query: 415 PSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQ 474
+ Y+ +LY++ +LT++G D+E +F + LIG L+ A + GN+ ++I
Sbjct: 345 --LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNIGSMIS 401
Query: 475 RMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDEL 534
M + + + R +K ++ ++ + +++R++++F W+ +D E+LK PD+L
Sbjct: 402 NMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKL 461
Query: 535 RSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCS 593
R++I ++++ + L ++ +F G L L L ++ +PG+Y+ ++GD + +Y +
Sbjct: 462 RAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKE 521
Query: 594 GSMEVLKDSMV--LAILGKGDLIG--ANLSIKDQVI--KTNADVKALTYCDLQCIILKGL 647
G + V+ D V +L G G + L+IK + A++K++ Y DL C+ L
Sbjct: 522 GKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDL 581
Query: 648 FEVLDLYPE 656
E L YP+
Sbjct: 582 MEALTEYPD 590
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 153 bits (387), Expect = 8e-37
Identities = 114/485 (23%), Positives = 228/485 (47%), Gaps = 33/485 (6%)
Query: 191 NVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDD 250
NV +PA + KK ++ S W I L FY + CF D+
Sbjct: 120 NVGSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACF---DE 176
Query: 251 LSTTRSTT--VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY-VTTWFIIDL 307
L + V D + ++L+++D+++ RT ++ + G ++ + + HY TT F +D+
Sbjct: 177 LQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDV 235
Query: 308 IAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV-LTLLMSMFALL 366
++ +P DL Y T V + ++ RL + + + + + + L+ ++
Sbjct: 236 LSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILII 295
Query: 367 AHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALY 426
HW ACI++ I K W++ + P +G + YI +LY
Sbjct: 296 IHWNACIYFAISKFIGFGTD------SWVYP---NISIPEHGR-------LSRKYIYSLY 339
Query: 427 FTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTR 486
++ +LT++G D E +F + L+G L+ A + GNV ++I M + + + +
Sbjct: 340 WSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398
Query: 487 TKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEI 546
+K +++ + + L+ R++ +F W+ +D E+LK PD+L+++I ++++ +
Sbjct: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458
Query: 547 L-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV- 604
L ++ +F+ G L L L ++ + +PG+Y+ ++GD + +Y + G + V+ D V
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
Query: 605 -LAILGKGDLIG----ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAH 659
+L G G N+ + A+++++ Y DL C+ L E L YPE A
Sbjct: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE-AK 577
Query: 660 KFVED 664
K +E+
Sbjct: 578 KALEE 582
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 151 bits (381), Expect = 4e-36
Identities = 110/468 (23%), Positives = 222/468 (47%), Gaps = 33/468 (7%)
Query: 208 KKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTT--VSDIAVE 265
KK ++ S W I L FY + CF D+L + V D + +
Sbjct: 155 KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACF---DELQSEYLMLWLVLDYSAD 211
Query: 266 ILFIIDIILNFRTTYVSKSGQVIFEARSICIHY-VTTWFIIDLIAALPFDLLYAFNVTVV 324
+L+++D+++ RT ++ + G ++ + + HY TT F +D+++ +P DL Y T
Sbjct: 212 VLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNY 270
Query: 325 SLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV-LTLLMSMFALLAHWMACIWYVIGKMERE 383
V + ++ RL + + + + + + L+ ++ HW ACI++ I K
Sbjct: 271 PEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGF 330
Query: 384 DNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSAN 443
W++ + P +G + YI +LY++ +LT++G
Sbjct: 331 GTD------SWVYP---NISIPEHGR-------LSRKYIYSLYWSTLTLTTIGETPPPVK 374
Query: 444 TDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQL 503
D E +F + L+G L+ A + GNV ++I M + + + + +K +++ + + L
Sbjct: 375 -DEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDL 433
Query: 504 KQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRS 562
+ R++ +F W+ +D E+LK PD+L+++I ++++ + L ++ +F+ G L
Sbjct: 434 ETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVE 493
Query: 563 LSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV--LAILGKGDLIG----A 616
L L ++ + +PG+Y+ ++GD + +Y + G + V+ D V +L G G
Sbjct: 494 LVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISIL 553
Query: 617 NLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVED 664
N+ + A+++++ Y DL C+ L E L YPE A K +E+
Sbjct: 554 NIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE-AKKALEE 600
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 143 bits (361), Expect = 8e-34
Identities = 122/542 (22%), Positives = 241/542 (44%), Gaps = 61/542 (11%)
Query: 212 FILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIID 271
+I+ +S F+ WD ++LL + +P + F ++ + V ++ + F++D
Sbjct: 84 WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEEN---SPPWIVFNVLSDTFFLLD 140
Query: 272 IILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLY------------- 317
++LNFRT V + G +++ R+I Y+ TWF++DLI+++P D ++
Sbjct: 141 LVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEV 200
Query: 318 ---AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HSTIVLTL-------LMSMFAL 365
A + +V +L +RLLRL RL++ + ++ + H T L L+ M L
Sbjct: 201 YKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLL 260
Query: 366 LAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAAL 425
L HW C+ +++ ++ + N + S Y AL
Sbjct: 261 LCHWDGCLQFLVPMLQDFPPDC------------------WVSINHMVNHSWGRQYSHAL 302
Query: 426 YFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHT 485
+ +S + +G+G + + ++ +M++GA +A+ G+ TA+IQ + S Y
Sbjct: 303 FKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 362
Query: 486 RTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKE 545
+ K ++ ++ H LP +QR+ EY++ + D +L + + LR +I +
Sbjct: 363 KYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIINFTCRG 421
Query: 546 IL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV 604
++ + LF A + ++ ++ PG+ ++R+G + +YF+ G + VL
Sbjct: 422 LVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGAR 481
Query: 605 LAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVED 664
L G G + + A V+A TYC L + + VL+ +P F E
Sbjct: 482 DTRLTDGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF-ET 538
Query: 665 IQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEA 724
+ D LR G ++ ++ R S+ P +G I ++ +V+ + + G A
Sbjct: 539 VAMDRL--LRIGKKNSILQRKR-----SEPSPGSSGGIMEQ--HLVQHDRDMARGVRGRA 589
Query: 725 VS 726
S
Sbjct: 590 PS 591
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 140 bits (354), Expect = 5e-33
Identities = 115/450 (25%), Positives = 221/450 (49%), Gaps = 40/450 (8%)
Query: 233 FYVAVTVPYNVCFIGN----DDLSTTRSTT--VSDIAVEILFIIDIILNFRTTYVSKSGQ 286
F +A+ V YN C + DL V D ++++I D+ + RT ++ + G
Sbjct: 145 FVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQ-GL 203
Query: 287 VIFEARSICIHYV-TTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKL 345
++ + + + +Y+ T F +D+ + +P DL+Y F V + S ++ RLL R+ +
Sbjct: 204 LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY-FAVDIHSPE--VRFNRLLHFARMFEFF 260
Query: 346 DRYSQHSTIV----LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKR 401
DR + ++ L+ ++ HW ACI+Y I K S+ W++
Sbjct: 261 DRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISK------SIGFGVDTWVYP---N 311
Query: 402 LESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALM 461
+ P YG + YI LY++ +LT++G D E +F I LIG L+
Sbjct: 312 ITDPEYGY-------LAREYIYCLYWSTLTLTTIGETPPPVK-DEEYLFVIFDFLIGVLI 363
Query: 462 HALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGI 521
A + GNV ++I M + + + + +K +++ + + ++ +++ +F W+ +
Sbjct: 364 FATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTV 423
Query: 522 DSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLR 580
D E+LK+ P +LR++I ++++ L ++ +F G L L L ++ +PG+Y+ R
Sbjct: 424 DEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483
Query: 581 QGDALQAIYFVCSGSMEVLKDSMV--LAILGKGDLIG--ANLSIKDQVI--KTNADVKAL 634
+GD + +Y + G + V+ D V A+L G G + L+IK + + A++++L
Sbjct: 484 KGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 543
Query: 635 TYCDLQCIILKGLFEVLDLYPEYAHKFVED 664
Y DL C+ L E + YP+ A K +E+
Sbjct: 544 GYSDLFCLSKDDLMEAVTEYPD-AKKVLEE 572
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 133 bits (334), Expect = 1e-30
Identities = 99/412 (24%), Positives = 207/412 (50%), Gaps = 37/412 (8%)
Query: 259 VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTW-FIIDLIAALPFDLLY 317
V D ++L+++D+++ F T ++ + V+ + R I YV TW F +DL + +P D++Y
Sbjct: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129
Query: 318 AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI-----VLTLLMSMFALLAHWMAC 372
V + L+ R LR RL + DR + + L++ +F ++ HW +C
Sbjct: 130 ---VRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWNSC 185
Query: 373 IWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG-PSIRSAYIAALYFTLSS 431
+++ + + LG ++ Y + G +R Y+ + YF+
Sbjct: 186 LYFALSRY-----------------LGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLI 228
Query: 432 LTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLK 491
LT+VG A + E +F + L+ + A + G+++++I M + + ++ +K
Sbjct: 229 LTTVGDTPPPAREE-EYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVK 287
Query: 492 DFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLS 550
++++ H+ ++L++R+++++Q + +L+ P+ LR+++ + ++ L ++
Sbjct: 288 KYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQ 347
Query: 551 LFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV--LAIL 608
+F+ L L L ++ +PGEY+ R+GD Q +Y + G + V+ D + A+L
Sbjct: 348 IFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVL 407
Query: 609 GKGDLIG--ANLSIKDQVI--KTNADVKALTYCDLQCIILKGLFEVLDLYPE 656
G G G + ++IK + + A++K+L Y DL C+ + L EVL YP+
Sbjct: 408 GAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 97.4 bits (241), Expect = 6e-20
Identities = 117/621 (18%), Positives = 253/621 (40%), Gaps = 82/621 (13%)
Query: 261 DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTW-FIIDLIAALPFDLLYAF 319
D ++++ +DI + + G +I + + + +Y+ + F +DL++ LP D LY
Sbjct: 695 DYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY-L 753
Query: 320 NVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLA-HWMACIWYVIG 378
V V L+ L + ++ + +L+ + + + + + L + H +C++Y
Sbjct: 754 KVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYY--- 810
Query: 379 KMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFG 438
W + + L S ++ + +G ++YI YF + +L ++G G
Sbjct: 811 -----------WASAY-----QGLGSTHWVYDGVG-----NSYIRCYYFAVKTLITIG-G 848
Query: 439 NVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHH 498
T E +F + G +++ G + ++ + + Y + ++ +
Sbjct: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908
Query: 499 LPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASR 557
+P+ ++ R+ +++ TW +D +EL+ PD++R D+ + +N I+ +++LF+ R
Sbjct: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
Query: 558 GCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVL---KDSMVLAILGKGDLI 614
+ + +++ P +Y+ ++G+ + +Y + +G ++VL VL L G +
Sbjct: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028
Query: 615 G-ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673
G +L + A+V A + +L + K L E+L YPE + + L N
Sbjct: 1029 GEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNN 1088
Query: 674 REGHESDVI--------SRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAV 725
+ E V+ +L N ++ + G G +L + +E E A
Sbjct: 1089 KPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHL--RARLKELAALEAAA 1146
Query: 726 SLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPN 785
+ + SS++ K + S H+ + + ++ P + +PP
Sbjct: 1147 KQQELVEQAKSSQDVK------------GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPG 1194
Query: 786 HNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPP 845
+ PP S +G E+G + E S RI P
Sbjct: 1195 SPP---------------SSPPPASLGRPEGEEEGPAEPEEH-----SVRICMSP----- 1229
Query: 846 LGDPEIGAAVLFIKAEETKQQ 866
PE G +L +K E +++
Sbjct: 1230 --GPEPGEQILSVKMPEEREE 1248
Score = 33.1 bits (74), Expect = 1.5
Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 4/92 (4%)
Query: 637 CDLQCI-ILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSE 695
CD+Q I IL G DL E ED D++ + + ++V+ ++ +
Sbjct: 287 CDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQG---TEVVPAYEEENKAVEKM 343
Query: 696 PKGNGNINKRLPSIVEDEEEEEEGEEEEAVSL 727
P+ I + E+EEEEEE EEEE +
Sbjct: 344 PRELSRIEEEKEDEEEEEEEEEEEEEEEVTEV 375
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 91.7 bits (226), Expect = 4e-18
Identities = 97/485 (20%), Positives = 206/485 (42%), Gaps = 52/485 (10%)
Query: 195 DKPAFPEYKVSDAKKSKFILLHF-------STFKAGWDWLILLATFYVAVTVPYNVCFIG 247
DKP Y++ K K L + ++ + D L LL V + +N CFI
Sbjct: 178 DKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIP 237
Query: 248 ------NDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT- 300
++DI +I+++ D++ + G +I ++ + HY T
Sbjct: 238 LRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTS 297
Query: 301 TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQ---KLDRYSQHSTIVLT 357
T F +D+ + +PFD+ Y F + + R+L+ + L+ + I
Sbjct: 298 TKFQLDVASIIPFDICYLF----FGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRV 353
Query: 358 LLMSMFAL-LAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPS 416
+ + + L + H AC++Y E + W+++ G+ GN
Sbjct: 354 IRTTGYLLFILHINACVYYWASNYEGIGTT------RWVYD-GE-------GNE------ 393
Query: 417 IRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRM 476
Y+ Y+ + +L ++G G T E +F + G + + + G + +I
Sbjct: 394 ----YLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
Query: 477 YSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRS 536
+ + + D ++ + +P+ +++R+ +++ TW +D ++LLK P ++
Sbjct: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
Query: 537 DITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGS 595
+ + +N I+ ++ LF+ + + L +K+ PG+++ ++G+ + +Y + G
Sbjct: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
Query: 596 MEVL---KDSMVLAILGKGDLIG-ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVL 651
++VL + VL L G + G +L + A+V A + +L + K L E+L
Sbjct: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
Query: 652 DLYPE 656
YP+
Sbjct: 629 VHYPD 633
>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
[Homo sapiens]
Length = 271
Score = 45.4 bits (106), Expect = 3e-04
Identities = 17/60 (28%), Positives = 40/60 (66%)
Query: 422 IAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWS 481
+ + +F++S++T++G+GN+S NT A ++F I L+G ++ +V + ++Q+ + W+
Sbjct: 104 VGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWA 163
>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
[Homo sapiens]
Length = 332
Score = 45.4 bits (106), Expect = 3e-04
Identities = 17/60 (28%), Positives = 40/60 (66%)
Query: 422 IAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWS 481
+ + +F++S++T++G+GN+S NT A ++F I L+G ++ +V + ++Q+ + W+
Sbjct: 104 VGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWA 163
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 40.8 bits (94), Expect = 0.007
Identities = 63/257 (24%), Positives = 102/257 (39%), Gaps = 47/257 (18%)
Query: 233 FYVAVTVPYNVCFI---GNDDLSTTRSTTVSDIAVEILFIIDI--ILNFRTTYVSKSGQV 287
F++AV+V NV ++R + + F +D +L F Y+ +
Sbjct: 194 FFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLR---- 249
Query: 288 IFEARSICIHYVTTWFIIDLIAALPF--DLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKL 345
+F A S C + +ID++A LP+ LL N V L+ R+ R+ K
Sbjct: 250 LFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIF----KF 305
Query: 346 DRYSQHSTIVLTLLMSM-----FALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGK 400
R+SQ I+ L S F L + MA I + E
Sbjct: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK---------------- 349
Query: 401 RLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGAL 460
G N SI AA ++T+ ++T++G+G++ +T A KIF L G L
Sbjct: 350 -------GTNKTNFTSIP----AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVL 398
Query: 461 MHALVFGNVTAIIQRMY 477
+ AL + + R+Y
Sbjct: 399 VIALPVPVIVSNFSRIY 415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,615,995
Number of Sequences: 37866
Number of extensions: 1852102
Number of successful extensions: 12374
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 11616
Number of HSP's gapped (non-prelim): 582
length of query: 1107
length of database: 18,247,518
effective HSP length: 113
effective length of query: 994
effective length of database: 13,968,660
effective search space: 13884848040
effective search space used: 13884848040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.