Search of human proteins with 27886648

Search of human proteins with 27886648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886648 potassium voltage-gated channel, subfamily H,
member 5 isoform 2 [Homo sapiens]
         (624 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886648 potassium voltage-gated channel, subfamily H, member...  1266   0.0  
gi|22024390 potassium voltage-gated channel, subfamily H, member...  1247   0.0  
gi|4504831 potassium voltage-gated channel, subfamily H, member ...  1115   0.0  
gi|27886646 potassium voltage-gated channel, subfamily H, member...  1112   0.0  
gi|27437001 potassium voltage-gated channel, subfamily H, member...  1100   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   482   e-136
gi|27886653 potassium voltage-gated channel, subfamily H, member...   470   e-132
gi|27886667 potassium voltage-gated channel, subfamily H, member...   466   e-131
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   463   e-130
gi|26051273 voltage-gated potassium channel, subfamily H, member...   461   e-130
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   442   e-124
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   437   e-122
gi|26051271 voltage-gated potassium channel, subfamily H, member...   414   e-115
gi|27886651 potassium voltage-gated channel, subfamily H, member...   400   e-111
gi|27886665 potassium voltage-gated channel, subfamily H, member...   327   2e-89
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   176   6e-44
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   170   4e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   168   2e-41
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   164   3e-40
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    150   3e-36
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   148   2e-35
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   148   2e-35
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   142   7e-34
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   142   7e-34
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    132   7e-31
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   108   1e-23
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    107   3e-23
gi|205361107 potassium channel, subfamily K, member 17 isoform 2...    45   2e-04
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ...    45   2e-04
gi|14589851 potassium channel, subfamily K, member 2 isoform b [...    44   3e-04

>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score = 1266 bits (3277), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 120
           EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH
Sbjct: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 120

Query: 121 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 180
           SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF
Sbjct: 121 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 180

Query: 181 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 240
           KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL
Sbjct: 181 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 240

Query: 241 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 300
           SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL
Sbjct: 241 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 300

Query: 301 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 360
           VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL
Sbjct: 301 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 360

Query: 361 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 420
           YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT
Sbjct: 361 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 420

Query: 421 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 480
           NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV
Sbjct: 421 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 480

Query: 481 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 540
           HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI
Sbjct: 481 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 540

Query: 541 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 600
           QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN
Sbjct: 541 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 600

Query: 601 SFSRNLTLTCNLRKRGWFSMANAL 624
           SFSRNLTLTCNLRKRGWFSMANAL
Sbjct: 601 SFSRNLTLTCNLRKRGWFSMANAL 624


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score = 1247 bits (3227), Expect = 0.0
 Identities = 615/615 (100%), Positives = 615/615 (100%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH
Sbjct: 59  MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 120
           EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH
Sbjct: 119 EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 178

Query: 121 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 180
           SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF
Sbjct: 179 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 238

Query: 181 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 240
           KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL
Sbjct: 239 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 298

Query: 241 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 300
           SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL
Sbjct: 299 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 358

Query: 301 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 360
           VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL
Sbjct: 359 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 418

Query: 361 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 420
           YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT
Sbjct: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478

Query: 421 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 480
           NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV
Sbjct: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538

Query: 481 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 540
           HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI
Sbjct: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598

Query: 541 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 600
           QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN
Sbjct: 599 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658

Query: 601 SFSRNLTLTCNLRKR 615
           SFSRNLTLTCNLRKR
Sbjct: 659 SFSRNLTLTCNLRKR 673


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score = 1115 bits (2883), Expect = 0.0
 Identities = 537/617 (87%), Positives = 585/617 (94%), Gaps = 2/617 (0%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE 
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHK 119
           +KVVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 120 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVS 179
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 180 FKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDL 239
           FKT+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 240 LSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFG 299
           LSCLPYD+INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY+EYGAAVLVLLVCVFG
Sbjct: 301 LSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG 360

Query: 300 LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS-AGIWEGGPSKD 358
           L AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQLA+ IGTPY++N S +G WEGGPSK+
Sbjct: 361 LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKN 420

Query: 359 SLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYA 418
           S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA+MM+GSLLYATIFGNVTTIFQQMYA
Sbjct: 421 SVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYA 480

Query: 419 NTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADI 478
           NTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVSTWSMS+GIDTEKVL ICPKDMRADI
Sbjct: 481 NTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI 540

Query: 479 CVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLE 538
           CVHLNRKVF EHPAFRLASDGCLRALA+EFQT+HCAPGDLIYHAGESVD+LCFVVSGSLE
Sbjct: 541 CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLE 600

Query: 539 VIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAF 598
           VIQDDEVVAILGKGDVFGD+FWKE TLA +CANVRALTYCDLH+IKR+AL KVL+FYTAF
Sbjct: 601 VIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 660

Query: 599 ANSFSRNLTLTCNLRKR 615
           ++SFSRNL LT NLRKR
Sbjct: 661 SHSFSRNLILTYNLRKR 677


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score = 1112 bits (2877), Expect = 0.0
 Identities = 549/549 (100%), Positives = 549/549 (100%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH
Sbjct: 59  MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 120
           EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH
Sbjct: 119 EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 178

Query: 121 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 180
           SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF
Sbjct: 179 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 238

Query: 181 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 240
           KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL
Sbjct: 239 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 298

Query: 241 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 300
           SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL
Sbjct: 299 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 358

Query: 301 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 360
           VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL
Sbjct: 359 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 418

Query: 361 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 420
           YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT
Sbjct: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478

Query: 421 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 480
           NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV
Sbjct: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538

Query: 481 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 540
           HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI
Sbjct: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598

Query: 541 QDDEVVAIL 549
           QDDEVVAIL
Sbjct: 599 QDDEVVAIL 607


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score = 1100 bits (2845), Expect = 0.0
 Identities = 537/644 (83%), Positives = 585/644 (90%), Gaps = 29/644 (4%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE 
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHK 119
           +KVVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 120 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVS 179
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 180 FKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDL 239
           FKT+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 240 LSCLPYDIINAFENVDE---------------------------GISSLFSSLKVVRLLR 272
           LSCLPYD+INAFENVDE                           GISSLFSSLKVVRLLR
Sbjct: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360

Query: 273 LGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 332
           LGRVARKLDHY+EYGAAVLVLLVCVFGL AHW+ACIWYSIGDYE+ DE T TI+ +SWLY
Sbjct: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420

Query: 333 QLALSIGTPYRYNTS-AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 391
           QLA+ IGTPY++N S +G WEGGPSK+S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+
Sbjct: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480

Query: 392 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYI 451
           VA+MM+GSLLYATIFGNVTTIFQQMYANTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYI
Sbjct: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540

Query: 452 VSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTI 511
           VSTWSMS+GIDTEKVL ICPKDMRADICVHLNRKVF EHPAFRLASDGCLRALA+EFQT+
Sbjct: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600

Query: 512 HCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACAN 571
           HCAPGDLIYHAGESVD+LCFVVSGSLEVIQDDEVVAILGKGDVFGD+FWKE TLA +CAN
Sbjct: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660

Query: 572 VRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKR 615
           VRALTYCDLH+IKR+AL KVL+FYTAF++SFSRNL LT NLRKR
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKR 704


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  482 bits (1241), Expect = e-136
 Identities = 258/666 (38%), Positives = 386/666 (57%), Gaps = 63/666 (9%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQ+  TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE 
Sbjct: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119

Query: 61  EKVVLFLCTFKDITLFKQPIEDDS------------------------------------ 84
             V++F+  F+D+          S                                    
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179

Query: 85  -----TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYK 138
                T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK
Sbjct: 180 QIPQFTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYK 238

Query: 139 QEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA---------- 188
            +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +          
Sbjct: 239 LQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCS 298

Query: 189 -WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
              V+D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D+
Sbjct: 299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDL 358

Query: 248 INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLAC 307
           +  F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLAC
Sbjct: 359 L-IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLAC 417

Query: 308 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYF 367
           IWY+IG+ E    + + I    WL  L + +G  Y  +  A     GPS    YV++LYF
Sbjct: 418 IWYAIGNVER-PYLEHKI---GWLDSLGVQLGKRYNGSDPAS----GPSVQDKYVTALYF 469

Query: 368 TMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEML 427
           T +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 470 TFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQM 529

Query: 428 NNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVF 487
             V++F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R + 
Sbjct: 530 LRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALL 589

Query: 488 NEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVA 547
              PAF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVA
Sbjct: 590 QHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVA 649

Query: 548 ILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLT 607
           ILGK D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L 
Sbjct: 650 ILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLE 709

Query: 608 LTCNLR 613
           +T NLR
Sbjct: 710 VTFNLR 715


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  470 bits (1209), Expect = e-132
 Identities = 239/517 (46%), Positives = 343/517 (66%), Gaps = 20/517 (3%)

Query: 108 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 167
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 359 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 418

Query: 168 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 216
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 419 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 478

Query: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 479 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 537

Query: 277 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 336
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 538 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 593

Query: 337 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 396
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 594 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 649

Query: 397 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 456
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 650 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 709

Query: 457 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPG 516
            + GID   VL   P+ ++ADIC+HLN+ +     AFR AS GCLRALA++F+T H  PG
Sbjct: 710 YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPG 769

Query: 517 DLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALT 576
           D + H G+ + AL F+  GS+E+++DD VVAILGK D+FG++         + A+VRALT
Sbjct: 770 DTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALT 829

Query: 577 YCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 613
           YCDLH I+RE LL+VLD Y  F++ F  NL LT NLR
Sbjct: 830 YCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 36/74 (48%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQK  TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+ 
Sbjct: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119

Query: 61  EKVVLFLCTFKDIT 74
              ++F+  F+ +T
Sbjct: 120 GVAMMFIINFEYVT 133


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  466 bits (1200), Expect = e-131
 Identities = 248/631 (39%), Positives = 394/631 (62%), Gaps = 33/631 (5%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQKS +C F++G  T+++ + ++ ++ +       E++ YKKN +P W  + I PI+NE 
Sbjct: 61  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120

Query: 61  EKVVLFLCTFKDITLFKQPI-----EDDSTKGWTKFA-RLTRALTNSRSVLQQLTPMNKT 114
             VVLFL +FKDIT  K  I     ++D  KG ++       A   SR+VL  ++     
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISG---- 176

Query: 115 EVVHKHSRLAEVLQLGSDIL------PQYKQEAPKTPPHIILHYCAFKTTWDWVILILTF 168
              H   R    L++ +++       P+YK    K    I+LH+  FK  WDW+IL+ TF
Sbjct: 177 ---HLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATF 233

Query: 169 YTAIMVPYNVSFKTKQN---NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKL 225
           Y A+ VPYNV F    +     +  V D  V+++F++DI+LNF TT+V   G+VI + + 
Sbjct: 234 YVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARS 293

Query: 226 IRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLE 285
           I ++Y+ TWF+IDL++ LP+D++ AF NV   + SL   LK VRLLRL R+ +KLD Y +
Sbjct: 294 ICIHYVTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQ 350

Query: 286 YGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345
           +   VL LL+ +F L+AHW+ACIWY IG  E  D      ++  WL++L   + +PY  N
Sbjct: 351 HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV-GWLHELGKRLESPYYGN 409

Query: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
            + G    GPS  S Y+++LYFT++SLT++GFGN++  TD EK+FS+  M++G+L++A +
Sbjct: 410 NTLG----GPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALV 465

Query: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465
           FGNVT I Q+MY+  + YH    +++DF++++ +P+ L +R+++Y  +TWS++ GID+ +
Sbjct: 466 FGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNE 525

Query: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525
           +L   P ++R+DI +HLN+++  +   F  AS GCLR+L++  +T  CAPG+ +   G++
Sbjct: 526 LLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDA 584

Query: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585
           + A+ FV SGS+EV++D  V+AILGKGD+ G     +  +    A+V+ALTYCDL  I  
Sbjct: 585 LQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIIL 644

Query: 586 EALLKVLDFYTAFANSFSRNL--TLTCNLRK 614
           + L +VLD Y  +A+ F  ++   LT NLR+
Sbjct: 645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLRE 675


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  463 bits (1191), Expect = e-130
 Identities = 237/528 (44%), Positives = 339/528 (64%), Gaps = 25/528 (4%)

Query: 98  LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 157
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408

Query: 158 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 205
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468

Query: 206 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 265
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524

Query: 266 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 325
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583

Query: 326 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635

Query: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695

Query: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755

Query: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTL 565
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILGK D+FG+        
Sbjct: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARP 815

Query: 566 AHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 613
             +  +VRALTYCDLH I R+ LL+VLD Y  F++ F  +L +T NLR
Sbjct: 816 GKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQ+  TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE 
Sbjct: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119

Query: 61  EKVVLFLCTFKDI---TLFKQPIEDDSTKG 87
             V++F+  F+ +    +   P  D + +G
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRG 149


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  461 bits (1187), Expect = e-130
 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%)

Query: 125 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 184
           EVL LG+D+LP+YK +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F  K+
Sbjct: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95

Query: 185 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 232
                             V+D +VD++F+VDI++NF TT+V    EV+S P  I ++Y K
Sbjct: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155

Query: 233 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 292
            WF+ID+++ +P+D++        G   L   LK  RLLRL RVARKLD Y EYGAAVL 
Sbjct: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211

Query: 293 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 352
           LL+C F L+AHWLACIWY+IG+ E    + + I    WL+ L   IG PY    S+G+  
Sbjct: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262

Query: 353 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 412
           GGPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I
Sbjct: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322

Query: 413 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 472
            Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL   P+
Sbjct: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382

Query: 473 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 532
            ++ADIC+HLNR +      FR A+ GCLRALA++F+T H  PGD + HAG+ + AL F+
Sbjct: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442

Query: 533 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 592
             GS+E+++ D VVAILGK D+FG+          +  +VRALTYCDLH I R+ LL+VL
Sbjct: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502

Query: 593 DFYTAFANSFSRNLTLTCNLR 613
           D Y  F++ F  +L +T NLR
Sbjct: 503 DMYPEFSDHFWSSLEITFNLR 523


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  442 bits (1137), Expect = e-124
 Identities = 249/643 (38%), Positives = 381/643 (59%), Gaps = 44/643 (6%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQ+   CSF+YG  T +   +++R+  D ++    E++LY+K+  P W  + + PI+NE 
Sbjct: 61  MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120

Query: 61  EKVVLFLCTFKDITLFKQPIEDDSTK----GWTKFARLTRALTN-----SRSVLQQLTPM 111
            +V LFL + KDI+  K     D  K    G  ++ R      N     SR+VL  L+  
Sbjct: 121 GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH 180

Query: 112 NKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTA 171
            + +   KH +L + +      LP+YK  A +  P I+LH  A + TWD  IL+ T Y A
Sbjct: 181 LQKQPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 239

Query: 172 IMVPYNVSFKTKQNNIAWL----VLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIR 227
           + VPY+V   T +   A      V D  V+V+F++DIVLNF TTFV   G+V+  PK I 
Sbjct: 240 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSIC 299

Query: 228 MNYLKTWFVIDLLSCLPYDIINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEY 286
           ++Y+ TWF++D+++ LP+D+++AF+ NV  G       LK VRLLRL R+  +LD Y +Y
Sbjct: 300 LHYVTTWFLLDVIAALPFDLLHAFKVNVYFGA----HLLKTVRLLRLLRLLPRLDRYSQY 355

Query: 287 GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRY-- 344
            A VL LL+ VF L+AHW+AC+W+ IG  E+    +   +I  WL +LA  + TPY    
Sbjct: 356 SAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEI-GWLQELARRLETPYYLVG 414

Query: 345 -----NTSAGIWE----------------GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPT 383
                  S+G  +                GGPS  S Y++SLYF ++SLT++GFGN++  
Sbjct: 415 RRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSAN 474

Query: 384 TDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGL 443
           TD EK+FS+  M++G+L++A +FGNVT I Q+MYA    YH    ++RD+++++++PK L
Sbjct: 475 TDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPL 534

Query: 444 SERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRA 503
            +R+++Y  +TW+++ GIDT ++L   P ++RADI +HL+++V  + P F  AS GCLRA
Sbjct: 535 KQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRA 593

Query: 504 LAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKET 563
           L++  +   C PG+ + H G+++ AL FV SGS+EV++   V+AILGKGD+ G    +  
Sbjct: 594 LSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRRE 653

Query: 564 TLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL 606
            +  A A+V+ LTYC L  ++   L   L  Y  FA  FSR L
Sbjct: 654 QVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGL 696


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  437 bits (1123), Expect = e-122
 Identities = 244/648 (37%), Positives = 387/648 (59%), Gaps = 52/648 (8%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQK+ +C F+YG  T +  ++++ +  + ++ +  E+  Y+K+ +  W  + + PI+NE 
Sbjct: 61  MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120

Query: 61  EKVVLFLCTFKDITLFKQP-IEDDSTKGWTKFA----------RLTRALTNSRSVLQQLT 109
            +VVLFL +FKDIT    P +     +G +             +   A   SR+VL +LT
Sbjct: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180

Query: 110 PMNKTEVVHKHSRLAEVLQLGSDI------LPQYKQEAPKTPPHIILHYCAFKTTWDWVI 163
                   H   R    ++  +++      +P+YK  +      ++LHY   K  WD +I
Sbjct: 181 G-------HFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLI 233

Query: 164 LILTFYTAIMVPYNVSFK----TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEV 219
           L+ TFY A+ VPYNV F     T   +   LV D  V+++F++DI+LNF TT+V   G+V
Sbjct: 234 LLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQV 293

Query: 220 ISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARK 279
           IS P+ I ++YL TWF IDL++ LP+D++  F      ++SL   LK VRLLRL R+ +K
Sbjct: 294 ISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQK 350

Query: 280 LDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID-SWLYQLALSI 338
           L+ Y +  A VL LL+ VF L+AHW+ACIWY IG  E+  E  + +  D  WL++L   +
Sbjct: 351 LERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREM--EANDPLLWDIGWLHELGKRL 408

Query: 339 GTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVG 398
             PY  N S G    GPS+ S Y+++LYFT++SLT++GFGN+   TD EK+FS+  M++G
Sbjct: 409 EVPY-VNGSVG----GPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIG 463

Query: 399 SLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMS 458
           +L++A +FGNVT I Q+MY+  + YH  + +++DF++++++P+ L +R+++Y  +TW+++
Sbjct: 464 ALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVN 523

Query: 459 KGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDL 518
            GID  ++L   P ++RADI +HLNR++  + P F  AS GCLRAL++  +T  CAPG+ 
Sbjct: 524 SGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEY 582

Query: 519 IYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFG----------DIFWKETTLAHA 568
           +   G+++ A  +V SGSLEV++D+ V+AILGKGD+ G           +      +   
Sbjct: 583 LLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKT 642

Query: 569 CANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRK 614
            A+V+ALTYC L  +    L +VL  Y  +  +F   L   LT NLR+
Sbjct: 643 SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  414 bits (1063), Expect = e-115
 Identities = 209/467 (44%), Positives = 301/467 (64%), Gaps = 25/467 (5%)

Query: 98  LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 157
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408

Query: 158 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 205
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468

Query: 206 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 265
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524

Query: 266 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 325
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583

Query: 326 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635

Query: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695

Query: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755

Query: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKG 552
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILG G
Sbjct: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQ+  TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE 
Sbjct: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119

Query: 61  EKVVLFLCTFKDI---TLFKQPIEDDSTKG 87
             V++F+  F+ +    +   P  D + +G
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRG 149


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  400 bits (1028), Expect = e-111
 Identities = 231/666 (34%), Positives = 345/666 (51%), Gaps = 116/666 (17%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQ+  TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE 
Sbjct: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119

Query: 61  EKVVLFLCTFKDITLFKQPIEDDS------------------------------------ 84
             V++F+  F+D+          S                                    
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179

Query: 85  -----TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYK 138
                T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK
Sbjct: 180 QIPQFTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYK 238

Query: 139 QEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA---------- 188
            +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +          
Sbjct: 239 LQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCS 298

Query: 189 -WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
              V+D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D+
Sbjct: 299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDL 358

Query: 248 INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLAC 307
           +  F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLAC
Sbjct: 359 L-IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLAC 417

Query: 308 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYF 367
           I                                     TS G     P+ +S  V S+  
Sbjct: 418 ICSL----------------------------------TSVGFGNVSPNTNSEKVFSI-- 441

Query: 368 TMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEML 427
                                     +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 442 -------------------------CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQM 476

Query: 428 NNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVF 487
             V++F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R + 
Sbjct: 477 LRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALL 536

Query: 488 NEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVA 547
              PAF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVA
Sbjct: 537 QHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVA 596

Query: 548 ILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLT 607
           ILGK D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L 
Sbjct: 597 ILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLE 656

Query: 608 LTCNLR 613
           +T NLR
Sbjct: 657 VTFNLR 662


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  327 bits (838), Expect = 2e-89
 Identities = 167/385 (43%), Positives = 248/385 (64%), Gaps = 21/385 (5%)

Query: 108 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 167
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 352 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 411

Query: 168 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 216
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 412 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 471

Query: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 472 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 530

Query: 277 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 336
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 531 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 586

Query: 337 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 396
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 587 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 642

Query: 397 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 456
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 643 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 702

Query: 457 MSKGIDTEKV-LSICPKDMRADICV 480
            + GID   V +S+   +  A I V
Sbjct: 703 YTNGIDMNMVCMSVFQNESAAGIIV 727



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 22/74 (29%), Positives = 36/74 (48%)

Query: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
           MQK  TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+ 
Sbjct: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119

Query: 61  EKVVLFLCTFKDIT 74
              ++F+  F+ +T
Sbjct: 120 GVAMMFIINFEYVT 133


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  176 bits (446), Expect = 6e-44
 Identities = 136/501 (27%), Positives = 228/501 (45%), Gaps = 60/501 (11%)

Query: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188
           GS    + +QE  KT    I+H Y  F+  WD ++LI+     +++P  ++F T+Q    
Sbjct: 115 GSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTP 174

Query: 189 WLVLDSVVDVIFLVDIVLNFHTTFVG-PGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
           W++ +   D +FL+D+++NF T  V     E+I DPK+I+MNYLK+WFV+D +S +P D 
Sbjct: 175 WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDY 234

Query: 248 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 289
           I  F  V++G+ S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 235 I--FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 292

Query: 290 VLVL----LVCVFGLVAHWLACIWYSI---GDYEVIDEVT-NTIQIDSWLYQLALSIGTP 341
             V+    L+ +  L+ HW  C+ + +    D+     V+ N +  DSW        G  
Sbjct: 293 SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--------GKQ 344

Query: 342 YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLL 401
           Y Y                   +L+  M+ +  IG+G  AP +  +   ++  M+VG+  
Sbjct: 345 YSY-------------------ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATC 385

Query: 402 YATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGI 461
           YA   G+ T + Q + ++  +Y E    V  ++  +++P  + +++ DY    +   K  
Sbjct: 386 YAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKIF 444

Query: 462 DTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 521
           D E +L+     +R +I     RK+    P F  A    + A+  + +     PGD I  
Sbjct: 445 DEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIR 504

Query: 522 AGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLH 581
            G     + F+  G   VI        L  G  FG+I     T     A+VRA TYC L+
Sbjct: 505 EGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICL--LTKGRRTASVRADTYCRLY 562

Query: 582 IIKREALLKVLDFYTAFANSF 602
            +  +   +VL+ Y     +F
Sbjct: 563 SLSVDNFNEVLEEYPMMRRAF 583


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  170 bits (430), Expect = 4e-42
 Identities = 130/495 (26%), Positives = 218/495 (44%), Gaps = 48/495 (9%)

Query: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188
           GS    + +QE  K+    I+H Y  F+  WD  +L+L     I++P  ++F   +N   
Sbjct: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294

Query: 189 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
           W+V + V D  FL+D+VLNF T   V    E+I DP+ I+M YLK+WF++D +S +P D 
Sbjct: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354

Query: 248 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLEYG------AAV 290
           I       +D  +     +L++V         RLLRL R+ R +  + E        A+ 
Sbjct: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414

Query: 291 LVLLVCVFG---LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS 347
           +V +V + G   L+ HW  C+ + +        +      D W       +      N S
Sbjct: 415 VVRIVNLIGMMLLLCHWDGCLQFLV-------PMLQDFPDDCW-------VSINNMVNNS 460

Query: 348 AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFG 407
            G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA   G
Sbjct: 461 WG---------KQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIG 511

Query: 408 NVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVL 467
           + T + Q + ++  +Y E    V  ++  +++P    +R+ DY    +   K  D E +L
Sbjct: 512 HATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESIL 570

Query: 468 SICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVD 527
               + +R +I     RK+    P F  A    + ++  + +     PGD I   G    
Sbjct: 571 GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK 630

Query: 528 ALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREA 587
            + F+  G + V+        L  G  FG+I     T     A+VRA TYC L+ +  + 
Sbjct: 631 KMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYSLSVDN 688

Query: 588 LLKVLDFYTAFANSF 602
             +VL+ Y     +F
Sbjct: 689 FNEVLEEYPMMRRAF 703


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  168 bits (425), Expect = 2e-41
 Identities = 130/497 (26%), Positives = 220/497 (44%), Gaps = 52/497 (10%)

Query: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188
           GS    + +QE  K+    I+H Y  F+  WD+ +L+      I++P  ++F   +    
Sbjct: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243

Query: 189 WLVLDSVVDVIFLVDIVLNFHTTFV-GPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
           W+V + V D  FL+D+VLNF T  V     E+I DP+ I+  YL+TWFV+D +S +P D 
Sbjct: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303

Query: 248 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 289
           I  F  V++GI S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361

Query: 290 VLVLLVC----VFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345
             V+ +C    +  L+ HW  C+ + +        +      + W     +SI     ++
Sbjct: 362 SAVMRICNLISMMLLLCHWDGCLQFLV-------PMLQDFPRNCW-----VSINGMVNHS 409

Query: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
            S            LY  +L+  M+ +  IG+G  AP +  +   ++  M+VG+  YA  
Sbjct: 410 WS-----------ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMF 458

Query: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465
            G+ T + Q + ++  +Y E    V  ++  +++P    +++ DY    +   K  D + 
Sbjct: 459 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDS 517

Query: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525
           +L      +R +I     RK+    P F  A    + A+  + +     PGD I   G  
Sbjct: 518 ILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTI 577

Query: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585
              + F+  G + V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 578 GKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 635

Query: 586 EALLKVLDFYTAFANSF 602
           +   +VL+ Y     +F
Sbjct: 636 DNFNEVLEEYPMMRRAF 652


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  164 bits (414), Expect = 3e-40
 Identities = 127/497 (25%), Positives = 221/497 (44%), Gaps = 50/497 (10%)

Query: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188
           GS    + +QE  K+    I+H Y  F+  WD ++L+L     I++P  ++F  ++N+  
Sbjct: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125

Query: 189 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYD- 246
           W+V + + D  FL+D+VLNF T   V  G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185

Query: 247 ---IINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLE-----YGAA 289
              ++     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245

Query: 290 VLVL----LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345
             V+    L+ +  L+ HW  C+ + +        +      D W       +   +  N
Sbjct: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLV-------PMLQDFPPDCW-------VSINHMVN 291

Query: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
            S G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA  
Sbjct: 292 HSWG---------RQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342

Query: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465
            G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   K  D E 
Sbjct: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEES 401

Query: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525
           +L    + +R +I     R +    P F  A    + A+  + +     PGDL+   G  
Sbjct: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461

Query: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585
              + F+  G L V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 519

Query: 586 EALLKVLDFYTAFANSF 602
           +    VL+ +     +F
Sbjct: 520 DHFNAVLEEFPMMRRAF 536


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  150 bits (379), Expect = 3e-36
 Identities = 119/456 (26%), Positives = 212/456 (46%), Gaps = 43/456 (9%)

Query: 151 HYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNF 208
           +YC     W +VI +   Y   ++     F   Q    + WLVLD V DV+++ D+ +  
Sbjct: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194

Query: 209 HTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKV 267
            T F+  G  ++ D K +R NY+ T  F +D+ S +P D+I    ++          L  
Sbjct: 195 RTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253

Query: 268 VRLLRL-GRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQ 326
            R+     R   + ++   +  + LVL + V   + HW ACI+Y+I         +    
Sbjct: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILV---IIHWNACIYYAISK-------SIGFG 303

Query: 327 IDSWLYQLALSIGTP-YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385
           +D+W+Y    +I  P Y Y                Y+  LY++  +LTTIG     P  D
Sbjct: 304 VDTWVYP---NITDPEYGYLARE------------YIYCLYWSTLTLTTIG-ETPPPVKD 347

Query: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445
            E +F +   ++G L++ATI GNV ++   M A    +   ++ V+ +++  +V KG+  
Sbjct: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407

Query: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505
           +V+ +    W+  K +D  ++L   P  +RA+I ++++     +   F     G L  L 
Sbjct: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467

Query: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIF---W 560
           ++ +    +PGD I   G+    +  +  G L V+ DD V   A+L  G  FG+I     
Sbjct: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527

Query: 561 KETTLAH-ACANVRALTYCDLHIIKREALLKVLDFY 595
           K + + +   AN+R+L Y DL  + ++ L++ +  Y
Sbjct: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY 563


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  148 bits (373), Expect = 2e-35
 Identities = 120/475 (25%), Positives = 214/475 (45%), Gaps = 55/475 (11%)

Query: 138 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 195
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191

Query: 196 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 255
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246

Query: 256 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 306
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300

Query: 307 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 366
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339

Query: 367 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 426
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398

Query: 427 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 486
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458

Query: 487 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 546
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518

Query: 547 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFY 595
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y
Sbjct: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 573


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  148 bits (373), Expect = 2e-35
 Identities = 120/475 (25%), Positives = 214/475 (45%), Gaps = 55/475 (11%)

Query: 138 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 195
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209

Query: 196 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 255
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 210 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 264

Query: 256 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 306
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 265 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 318

Query: 307 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 366
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 319 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 357

Query: 367 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 426
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 358 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416

Query: 427 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 486
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476

Query: 487 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 546
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536

Query: 547 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFY 595
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y
Sbjct: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 591


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  142 bits (359), Expect = 7e-34
 Identities = 116/449 (25%), Positives = 203/449 (45%), Gaps = 40/449 (8%)

Query: 159 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296

Query: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350

Query: 277 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 332
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 403

Query: 333 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 392
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 404 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 448

Query: 393 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 452
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 449 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 508

Query: 453 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 512
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 509 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 568

Query: 513 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 568
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 569 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 628

Query: 569 --CANVRALTYCDLHIIKREALLKVLDFY 595
              AN++++ Y DL  + ++ L++ L  Y
Sbjct: 629 RRTANIKSIGYSDLFCLSKDDLMEALTEY 657


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  142 bits (359), Expect = 7e-34
 Identities = 116/449 (25%), Positives = 203/449 (45%), Gaps = 40/449 (8%)

Query: 159 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 168 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 227

Query: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 228 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 281

Query: 277 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 332
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 282 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 334

Query: 333 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 392
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 335 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 379

Query: 393 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 452
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 380 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 439

Query: 453 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 512
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 440 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 499

Query: 513 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 568
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 500 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 559

Query: 569 --CANVRALTYCDLHIIKREALLKVLDFY 595
              AN++++ Y DL  + ++ L++ L  Y
Sbjct: 560 RRTANIKSIGYSDLFCLSKDDLMEALTEY 588


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  132 bits (333), Expect = 7e-31
 Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 44/451 (9%)

Query: 159 WDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
           W   ++    Y  I++     F   Q+   +AWLVLD   D+++L+D+V+ FHT F+  G
Sbjct: 37  WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQG 96

Query: 217 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 275
             V+ D   I   Y++TW F +DL S +P D++         +     +L++ R LR  R
Sbjct: 97  ILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149

Query: 276 VARKLDHYLEYGA-----AVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSW 330
           +    D      A      +  L++ +F +V HW +C+++++  Y            D+W
Sbjct: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGR-------DAW 201

Query: 331 LYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMF 390
           +Y                    G       Y+ S YF+   LTT+G     P  + E +F
Sbjct: 202 VYPDPAQ--------------PGFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLF 246

Query: 391 SVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY 450
            V   ++  + +ATI G+++++   M      ++     V+ ++KL  V + L  RV+D+
Sbjct: 247 MVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDW 306

Query: 451 IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 510
                   K  +   +L   P+ +RA++ V ++    +    F+      L  L ++ Q 
Sbjct: 307 YQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQP 366

Query: 511 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDI----FWKETT 564
              +PG+ +   G+    +  +  G L V+ DD +   A+LG G  FG+I         +
Sbjct: 367 QTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMS 426

Query: 565 LAHACANVRALTYCDLHIIKREALLKVLDFY 595
                AN+++L Y DL  + +E L +VL  Y
Sbjct: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  108 bits (271), Expect = 1e-23
 Identities = 102/448 (22%), Positives = 190/448 (42%), Gaps = 56/448 (12%)

Query: 159  WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDI-VLNFHTTFVGPGG 217
            W+W   +      I V +   ++T  N   WL++D + D+I+ +DI V      FV  GG
Sbjct: 667  WNWNCWL------IPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR-GG 719

Query: 218  EVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
            ++I+D K +R NYLK+  F +DLLS LP D    F  +  G++ L    + ++ +     
Sbjct: 720  DIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFFEF 775

Query: 277  ARKLDHYLEYGAAVLVLLVCVFGLVA-HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLA 335
              +L+  L       V+    + L + H  +C++Y    Y+ +           W+Y   
Sbjct: 776  NSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST-------HWVYD-- 826

Query: 336  LSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMM 395
              +G  Y                   +   YF + +L TIG G   P T  E +F +   
Sbjct: 827  -GVGNSY-------------------IRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNY 865

Query: 396  MVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTW 455
              G   ++ + G +  +     A    Y   +++   ++  Y++PK +  RV  +   TW
Sbjct: 866  FTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTW 925

Query: 456  SMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAP 515
                 +D  +++   P  MR D+ + +N  + ++   F+      +  +    +++   P
Sbjct: 926  HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLP 985

Query: 516  GDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA-----H 567
             D +   GE    +  + +G ++V+       V+  L  G VFG+I    + LA      
Sbjct: 986  NDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGGGNR 1041

Query: 568  ACANVRALTYCDLHIIKREALLKVLDFY 595
              ANV A  + +L I+ ++ L ++L  Y
Sbjct: 1042 RTANVVAHGFTNLFILDKKDLNEILVHY 1069


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  107 bits (268), Expect = 3e-23
 Identities = 94/449 (20%), Positives = 191/449 (42%), Gaps = 52/449 (11%)

Query: 161 WVILILTFYT--AIMVPYNVSF--KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
           W++L+   Y      +P  + F  +T  N   WL+ D + D+I+L D++          G
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280

Query: 217 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 275
           G++I D   +R +Y   T F +D+ S +P+DI   F     G + +F + ++++      
Sbjct: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336

Query: 276 VARKLDHYLEYGAAVLVLLVCVFGL-VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 334
               L+  ++      V+    + L + H  AC++Y   +YE I           W+Y  
Sbjct: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR-------WVYD- 388

Query: 335 ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAM 394
                                 + + Y+   Y+ + +L TIG G   P T  E +F +  
Sbjct: 389 ---------------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLN 426

Query: 395 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVST 454
              G  +++++ G +  +     AN N +   +++   ++  Y +PK + +RV  +   T
Sbjct: 427 FFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYT 486

Query: 455 WSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCA 514
           W   + +D   +L   P  ++  + + +N  + ++   F+      +  + +  +++   
Sbjct: 487 WDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYL 546

Query: 515 PGDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA----- 566
           PGD +   GE    +  +  G ++V+      +V+  L  G VFG+I    + LA     
Sbjct: 547 PGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEI----SLLAAGGGN 602

Query: 567 HACANVRALTYCDLHIIKREALLKVLDFY 595
              ANV A  + +L  + ++ L ++L  Y
Sbjct: 603 RRTANVVAHGFANLLTLDKKTLQEILVHY 631


>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
           [Homo sapiens]
          Length = 271

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
           TS G WE         V S +F+++++TTIG+GN++P T   ++F +   +VG  L   +
Sbjct: 96  TSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVV 147

Query: 406 FGNVTTIFQQ 415
              +  + QQ
Sbjct: 148 LNRLGHLMQQ 157


>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
           [Homo sapiens]
          Length = 332

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
           TS G WE         V S +F+++++TTIG+GN++P T   ++F +   +VG  L   +
Sbjct: 96  TSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVV 147

Query: 406 FGNVTTIFQQ 415
              +  + QQ
Sbjct: 148 LNRLGHLMQQ 157


>gi|14589851 potassium channel, subfamily K, member 2 isoform b
           [Homo sapiens]
          Length = 411

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 12/91 (13%)

Query: 323 NTIQIDSWLYQL--ALSIGTPYRYNTSAGI--WEGGPSKDSLYVSSLYFTMTSLTTIGFG 378
           N+ ++D  + Q+  A++ G     NTS  I  W+ G        SS +F  T +TTIGFG
Sbjct: 95  NSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLG--------SSFFFAGTVITTIGFG 146

Query: 379 NIAPTTDVEKMFSVAMMMVGSLLYATIFGNV 409
           NI+P T+  K+F +   ++G  L+  +   V
Sbjct: 147 NISPRTEGGKIFCIIYALLGIPLFGFLLAGV 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,614,038
Number of Sequences: 37866
Number of extensions: 877769
Number of successful extensions: 2608
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2400
Number of HSP's gapped (non-prelim): 124
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.