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Search of human proteins with 27436951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436951 lamin B2 [Homo sapiens]
(600 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436951 lamin B2 [Homo sapiens] 1149 0.0
gi|5031877 lamin B1 [Homo sapiens] 671 0.0
gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens] 601 e-172
gi|5031875 lamin A/C isoform 2 [Homo sapiens] 599 e-171
gi|27436948 lamin A/C isoform 3 [Homo sapiens] 584 e-167
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 166 4e-41
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 166 6e-41
gi|21264345 peripherin [Homo sapiens] 166 6e-41
gi|55749932 desmin [Homo sapiens] 165 1e-40
gi|62414289 vimentin [Homo sapiens] 162 8e-40
gi|14249342 internexin neuronal intermediate filament protein, a... 157 3e-38
gi|153791158 keratin 75 [Homo sapiens] 149 7e-36
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 148 2e-35
gi|4504919 keratin 8 [Homo sapiens] 147 2e-35
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 144 2e-34
gi|109255249 keratin 4 [Homo sapiens] 143 4e-34
gi|119395750 keratin 1 [Homo sapiens] 142 9e-34
gi|47132620 keratin 2 [Homo sapiens] 141 1e-33
gi|155969697 keratin 6C [Homo sapiens] 138 2e-32
gi|119395754 keratin 5 [Homo sapiens] 137 2e-32
gi|119703753 keratin 6B [Homo sapiens] 137 2e-32
gi|67782365 keratin 7 [Homo sapiens] 137 4e-32
gi|5031839 keratin 6A [Homo sapiens] 137 4e-32
gi|15618995 keratin 71 [Homo sapiens] 136 5e-32
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 135 1e-31
gi|109148552 keratin 3 [Homo sapiens] 134 2e-31
gi|148612803 keratin 6 irs4 [Homo sapiens] 134 3e-31
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 132 7e-31
gi|40354195 keratin 18 [Homo sapiens] 131 2e-30
gi|4557888 keratin 18 [Homo sapiens] 131 2e-30
>gi|27436951 lamin B2 [Homo sapiens]
Length = 600
Score = 1149 bits (2973), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISE 60
MATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISE
Sbjct: 1 MATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISE 60
Query: 61 KEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREG 120
KEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREG
Sbjct: 61 KEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREG 120
Query: 121 ELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEK 180
ELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEK
Sbjct: 121 ELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEK 180
Query: 181 ETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQAL 240
ETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQAL
Sbjct: 181 ETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQAL 240
Query: 241 EELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQ 300
EELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQ
Sbjct: 241 EELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQ 300
Query: 301 LSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDV 360
LSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDV
Sbjct: 301 LSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDV 360
Query: 361 KLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLE 420
KLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLE
Sbjct: 361 KLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLE 420
Query: 421 VEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGN 480
VEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGN
Sbjct: 421 VEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGN 480
Query: 481 WRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESF 540
WRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESF
Sbjct: 481 WRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESF 540
Query: 541 RTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM 600
RTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM
Sbjct: 541 RTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM 600
>gi|5031877 lamin B1 [Homo sapiens]
Length = 586
Score = 671 bits (1731), Expect = 0.0
Identities = 353/604 (58%), Positives = 459/604 (75%), Gaps = 26/604 (4%)
Query: 2 ATPLP----GRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLK 57
ATP+P RAGGP TPLSPTRLSRLQEKEELRELNDRLA YID+VR+LE EN L L+
Sbjct: 4 ATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQ 63
Query: 58 ISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKK 117
++E+EEV RE++G+KALYE+ELADARR LD+TARERA+LQIE+GK +AE D++ + K
Sbjct: 64 VTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAK 123
Query: 118 REGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQ 177
+E +L AQ ++++ E+ + + LA AL DK+ LE D+ +L+ Q+A+ E A AKKQ
Sbjct: 124 KESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQ 183
Query: 178 LEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMA 237
L ETL++VDLENRCQSL E+L+FRKS++EEE+ ETRR+HE RLVEVDS RQ EY++K+A
Sbjct: 184 LADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLA 243
Query: 238 QALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESL 297
QAL E+R QHD QVRLYK ELEQTY AKL++A+LSS+ N ++AREEL E+RMR+ESL
Sbjct: 244 QALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESL 303
Query: 298 SYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQEL 357
S QLS LQK++ A +RI+ELE+ +A E+D R+ML KE+EM E+RD MQQQL +Y++L
Sbjct: 304 SSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQL 363
Query: 358 LDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRK 417
LDVKLALDMEI+AYRKLLEGEEERLKLSPSPSSRVTVSRA+SS S R R KRK
Sbjct: 364 LDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRS------VRTTRGKRK 417
Query: 418 RLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQS 477
R++VEE + S ++ ASA+G+V IEEID++GKF++LKN S++DQ
Sbjct: 418 RVDVEE------------SEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQP 465
Query: 478 LGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTG 537
+G W + R++ + ++YK+T +Y+L+AGQ VT+WAA AGV SPP+ L+WK Q+SWGTG
Sbjct: 466 MGGWEMIRKIGD-TSVSYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTG 524
Query: 538 ESFRTVLVNADGEEVAMR-TVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRG 596
E + +L N+ GEEVA R TV K+++ E E EEEE EE+LFHQQG PR ++R
Sbjct: 525 EDVKVILKNSQGEEVAQRSTVFKTTIPEEEE--EEEEAAGVVVEEELFHQQGTPRASNRS 582
Query: 597 CYVM 600
C +M
Sbjct: 583 CAIM 586
>gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
Length = 664
Score = 601 bits (1549), Expect = e-172
Identities = 315/586 (53%), Positives = 428/586 (73%), Gaps = 26/586 (4%)
Query: 9 AGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
A +TPLSPTR++RLQEKE+L+ELNDRLA YIDRVR+LE EN L L+I+E EEV +RE
Sbjct: 14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSRE 73
Query: 69 VSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGR 128
VSGIKA YE+EL DAR+ LD A+ERARLQ+E+ K+R E E+ K+EG+L AQ R
Sbjct: 74 VSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQAR 133
Query: 129 VKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDL 188
+KDLE+L + E L+ ALS+KR LE ++ +LR Q+AK E AKKQL+ E L RVD
Sbjct: 134 LKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDA 193
Query: 189 ENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHD 248
ENR Q+++EELDF+K+++ EE+RET+RRHE RLVE+D+ +Q+E++ ++A AL+ELR+QH+
Sbjct: 194 ENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHE 253
Query: 249 EQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQA 308
+QV YK ELE+TY AKLD+A+ S+++N AA EEL+++R+R++SLS QLS LQKQ
Sbjct: 254 DQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQL 313
Query: 309 SAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEI 368
+A E ++R+LE+++A ERD R++L KE+EM EMR MQQQL EYQELLD+KLALDMEI
Sbjct: 314 AAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEI 373
Query: 369 NAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSG 428
+AYRKLLEGEEERL+LSPSP+S+ + RA+S SS G +K+++LE E S
Sbjct: 374 HAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS---QTQGGGSVTKKRKLESTESRSS- 429
Query: 429 PSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVL 488
+Q A SG V++EE+D EGKFV+L+N S++DQS+GNW+IKRQ
Sbjct: 430 ---------------FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNG 474
Query: 489 EGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNAD 548
+ + Y+F PK+ L+AGQ+VT+WAAGAG HSPP+ LVWK Q++WG G S RT L+N+
Sbjct: 475 DDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINST 534
Query: 549 GEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTS 594
GEEVAMR + +S + E++E E G++ L H G ++S
Sbjct: 535 GEEVAMRKLVRSVTV-------VEDDEDEDGDDLLHHHHGSHCSSS 573
>gi|5031875 lamin A/C isoform 2 [Homo sapiens]
Length = 572
Score = 599 bits (1544), Expect = e-171
Identities = 309/566 (54%), Positives = 421/566 (74%), Gaps = 19/566 (3%)
Query: 9 AGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
A +TPLSPTR++RLQEKE+L+ELNDRLA YIDRVR+LE EN L L+I+E EEV +RE
Sbjct: 14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSRE 73
Query: 69 VSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGR 128
VSGIKA YE+EL DAR+ LD A+ERARLQ+E+ K+R E E+ K+EG+L AQ R
Sbjct: 74 VSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQAR 133
Query: 129 VKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDL 188
+KDLE+L + E L+ ALS+KR LE ++ +LR Q+AK E AKKQL+ E L RVD
Sbjct: 134 LKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDA 193
Query: 189 ENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHD 248
ENR Q+++EELDF+K+++ EE+RET+RRHE RLVE+D+ +Q+E++ ++A AL+ELR+QH+
Sbjct: 194 ENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHE 253
Query: 249 EQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQA 308
+QV YK ELE+TY AKLD+A+ S+++N AA EEL+++R+R++SLS QLS LQKQ
Sbjct: 254 DQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQL 313
Query: 309 SAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEI 368
+A E ++R+LE+++A ERD R++L KE+EM EMR MQQQL EYQELLD+KLALDMEI
Sbjct: 314 AAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEI 373
Query: 369 NAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSG 428
+AYRKLLEGEEERL+LSPSP+S+ + RA+S SS G +K+++LE E S
Sbjct: 374 HAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS---QTQGGGSVTKKRKLESTESRSS- 429
Query: 429 PSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVL 488
+Q A SG V++EE+D EGKFV+L+N S++DQS+GNW+IKRQ
Sbjct: 430 ---------------FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNG 474
Query: 489 EGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNAD 548
+ + Y+F PK+ L+AGQ+VT+WAAGAG HSPP+ LVWK Q++WG G S RT L+N+
Sbjct: 475 DDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINST 534
Query: 549 GEEVAMRTVKKSSVMRENENGEEEEE 574
GEEVAMR + +S + E++ E+ ++
Sbjct: 535 GEEVAMRKLVRSVTVVEDDEDEDGDD 560
>gi|27436948 lamin A/C isoform 3 [Homo sapiens]
Length = 634
Score = 584 bits (1505), Expect = e-167
Identities = 301/542 (55%), Positives = 405/542 (74%), Gaps = 19/542 (3%)
Query: 9 AGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
A +TPLSPTR++RLQEKE+L+ELNDRLA YIDRVR+LE EN L L+I+E EEV +RE
Sbjct: 14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSRE 73
Query: 69 VSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGR 128
VSGIKA YE+EL DAR+ LD A+ERARLQ+E+ K+R E E+ K+EG+L AQ R
Sbjct: 74 VSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQAR 133
Query: 129 VKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDL 188
+KDLE+L + E L+ ALS+KR LE ++ +LR Q+AK E AKKQL+ E L RVD
Sbjct: 134 LKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDA 193
Query: 189 ENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHD 248
ENR Q+++EELDF+K+++ EE+RET+RRHE RLVE+D+ +Q+E++ ++A AL+ELR+QH+
Sbjct: 194 ENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHE 253
Query: 249 EQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQA 308
+QV YK ELE+TY AKLD+A+ S+++N AA EEL+++R+R++SLS QLS LQKQ
Sbjct: 254 DQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQL 313
Query: 309 SAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEI 368
+A E ++R+LE+++A ERD R++L KE+EM EMR MQQQL EYQELLD+KLALDMEI
Sbjct: 314 AAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEI 373
Query: 369 NAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSG 428
+AYRKLLEGEEERL+LSPSP+S+ + RA+S SS G +K+++LE E S
Sbjct: 374 HAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS---QTQGGGSVTKKRKLESTESRSS- 429
Query: 429 PSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVL 488
+Q A SG V++EE+D EGKFV+L+N S++DQS+GNW+IKRQ
Sbjct: 430 ---------------FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNG 474
Query: 489 EGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNAD 548
+ + Y+F PK+ L+AGQ+VT+WAAGAG HSPP+ LVWK Q++WG G S RT L+N+
Sbjct: 475 DDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINST 534
Query: 549 GE 550
GE
Sbjct: 535 GE 536
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 166 bits (421), Expect = 4e-41
Identities = 132/431 (30%), Positives = 213/431 (49%), Gaps = 72/431 (16%)
Query: 6 PGRAGGPATPLS--------PTRL--------------SRLQEKEELRELNDRLAHYIDR 43
PGR GP T LS PTR+ +R E+ E+ ELNDR A YI++
Sbjct: 27 PGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEK 86
Query: 44 VRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGK 103
VR LE +N L ++++ ++A ++LAD Q E+ +
Sbjct: 87 VRFLEQQNKALAAELNQ-----------LRAKEPTKLADV-------------YQAELRE 122
Query: 104 LRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQ 163
LR LD++ ++ + E E LA L+ R D LR +
Sbjct: 123 LRLRLDQLTANSARLEVERD------------------NLAQDLATVRQKLQDETNLRLE 164
Query: 164 LAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVE 223
AE+ A +++ ++ TL R+DLE + +SL+EE+ F + + EEEVRE + + R+ V
Sbjct: 165 ---AENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVH 221
Query: 224 VDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAA 283
V+ + + AL+E+R+Q++ E E+ Y++K ++ +N + A
Sbjct: 222 VELDVAKP---DLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQA 278
Query: 284 REELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEM 343
+ E + R +L+SL+ L L+ + E ++RE EE E +++ L E+E +
Sbjct: 279 KHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSL 338
Query: 344 RDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSG 403
+D M + L EYQ+LL+VKLALD+EI YRKLLEGEE R+ + S + + R TS +
Sbjct: 339 KDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQI-RETSLDTK 397
Query: 404 SLSATGRLGRS 414
S+S G L R+
Sbjct: 398 SVS-EGHLKRN 407
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 166 bits (420), Expect = 6e-41
Identities = 126/420 (30%), Positives = 205/420 (48%), Gaps = 70/420 (16%)
Query: 6 PGRAGGPATPLS--------PTRL--------------SRLQEKEELRELNDRLAHYIDR 43
PGR GP T LS PTR+ +R E+ E+ ELNDR A YI++
Sbjct: 27 PGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEK 86
Query: 44 VRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGK 103
VR LE +N L ++++ ++A ++LAD Q E+ +
Sbjct: 87 VRFLEQQNKALAAELNQ-----------LRAKEPTKLADV-------------YQAELRE 122
Query: 104 LRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQ 163
LR LD++ ++ + E E LA L+ R D LR +
Sbjct: 123 LRLRLDQLTANSARLEVERD------------------NLAQDLATVRQKLQDETNLRLE 164
Query: 164 LAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVE 223
AE+ A +++ ++ TL R+DLE + +SL+EE+ F + + EEEVRE + + R+ V
Sbjct: 165 ---AENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVH 221
Query: 224 VDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAA 283
V+ + + AL+E+R+Q++ E E+ Y++K ++ +N + A
Sbjct: 222 VELDVAKP---DLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQA 278
Query: 284 REELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEM 343
+ E + R +L+SL+ L L+ + E ++RE EE E +++ L E+E +
Sbjct: 279 KHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSL 338
Query: 344 RDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSG 403
+D M + L EYQ+LL+VKLALD+EI YRKLLEGEE R+ + S + + S+ G
Sbjct: 339 KDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTKDG 398
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 166 bits (420), Expect = 6e-41
Identities = 115/366 (31%), Positives = 198/366 (54%), Gaps = 52/366 (14%)
Query: 22 SRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELA 81
+R EK+EL+ELNDR A++I++VR LE +N L ++S+ +E + L + EL
Sbjct: 93 TRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARG---QEPARADQLCQQELR 149
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR L+ RER R+Q+E G +DL +L R E
Sbjct: 150 ELRRELELLGRERDRVQVE------------------------RDGLAEDLAALKQRLEE 185
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E + KR AE + +K ++ TL R++LE + +SL +E++F
Sbjct: 186 E-----TRKR-------------EDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEF 227
Query: 202 RKSVFEEEVRETR---RRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLEL 258
K + EEE+R+ + + + VEV+++ + E + AL ++R+Q++ E
Sbjct: 228 LKKLHEEELRDLQVSVESQQVQQVEVEATVKPE----LTAALRDIRAQYESIAAKNLQEA 283
Query: 259 EQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIREL 318
E+ Y++K ++++N +A A++E+ E+R +++SL+ ++ GL+ A ++REL
Sbjct: 284 EEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLREL 343
Query: 319 EEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGE 378
EE A E ++ E+E+ ++++ M + L EYQELL+VK+ALD+EI YRKLLEGE
Sbjct: 344 EEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGE 403
Query: 379 EERLKL 384
E R+ +
Sbjct: 404 ESRISV 409
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 165 bits (417), Expect = 1e-40
Identities = 116/383 (30%), Positives = 197/383 (51%), Gaps = 48/383 (12%)
Query: 22 SRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELA 81
+R EK EL+ELNDR A+YI++VR LE +N L +++ + RE + + LY
Sbjct: 104 TRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNR---LKGREPTRVAELY----- 155
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+E RE R Q+E+ LT + RV +V
Sbjct: 156 ------EEELRELRR-QVEV--------------------LTNQRARV----------DV 178
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E L D + L++ + E +AE+ A + ++ TL R+DLE R +SL EE+ F
Sbjct: 179 ERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIESLNEEIAF 238
Query: 202 RKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQT 261
K V EEE+RE + + + + V+V+ + + AL ++R+Q++ E E+
Sbjct: 239 LKKVHEEEIRELQAQLQEQQVQVEMDMSKP---DLTAALRDIRAQYETIAAKNISEAEEW 295
Query: 262 YQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEA 321
Y++K+ ++++N+ A A++E+ E R +++S + ++ L+ + ++RELE+
Sbjct: 296 YKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDR 355
Query: 322 MAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEER 381
A E ++ + E+E+ ++D M + L EYQ+LL+VK+ALD+EI YRKLLEGEE R
Sbjct: 356 FASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESR 415
Query: 382 LKLSPSPSSRVTVSRATSSSSGS 404
+ L S + + GS
Sbjct: 416 INLPIQTYSALNFRETSPEQRGS 438
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 162 bits (410), Expect = 8e-40
Identities = 118/381 (30%), Positives = 197/381 (51%), Gaps = 49/381 (12%)
Query: 22 SRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELA 81
+R EK EL+ELNDR A+YID+VR LE +N LL +E E++ + S + LYE E+
Sbjct: 99 TRTNEKVELQELNDRFANYIDKVRFLEQQNKILL---AELEQLKGQGKSRLGDLYEEEMR 155
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ LR ++D+ LT + RV EV
Sbjct: 156 E---------------------LRRQVDQ-----------LTNDKARV----------EV 173
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E D L + E Q +AE+ ++ ++ +L R+DLE + +SLQEE+ F
Sbjct: 174 ERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAF 233
Query: 202 RKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQT 261
K + EEE++E + + + + V++D + + AL ++R Q++ E E+
Sbjct: 234 LKKLHEEEIQELQAQIQEQHVQIDVDVSKP---DLTAALRDVRQQYESVAAKNLQEAEEW 290
Query: 262 YQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEA 321
Y++K ++++N+ A A++E E R +++SL+ ++ L+ + E ++RE+EE
Sbjct: 291 YKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEEN 350
Query: 322 MAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEER 381
A E ++ + + E+ M++ M + L EYQ+LL+VK+ALD+EI YRKLLEGEE R
Sbjct: 351 FAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESR 410
Query: 382 LKLSPSPSSRVTVSRATSSSS 402
+ L P P+ R T+ S
Sbjct: 411 ISL-PLPNFSSLNLRETNLDS 430
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 157 bits (396), Expect = 3e-38
Identities = 128/416 (30%), Positives = 208/416 (50%), Gaps = 61/416 (14%)
Query: 20 RLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESE 79
++ R EKE+L+ LNDR A +I++V LE +N L E+E
Sbjct: 88 KIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRAL----------------------EAE 125
Query: 80 LADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRS 139
LA R+ E +R Q E+ LRA+L+E + + R L G ++++ L R
Sbjct: 126 LAALRQRHAEPSRVGELFQRELRDLRAQLEEASSA---RSQALLERDGLAEEVQRLRARC 182
Query: 140 EVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEEL 199
E E RG E L+AQ ++ ++ TL R+DLE + +SL +EL
Sbjct: 183 EEE-------SRGREGAERALKAQ-----------QRDVDGATLARLDLEKKVESLLDEL 224
Query: 200 DFRKSVFEEEVRE---TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKL 256
F + V +EEV E T + + EVD + + + AL E+R+Q++
Sbjct: 225 AFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKP---DLTSALREIRAQYESLAAKNLQ 281
Query: 257 ELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIR 316
E+ Y++K + + ++ +A A+REE+ E R +L++ + ++ GL+ + E +I
Sbjct: 282 SAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQIL 341
Query: 317 ELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376
ELEE + E ++ + E ++ + M + L EYQ+LL+VK+ALD+EI AYRKLLE
Sbjct: 342 ELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLE 401
Query: 377 GEEERLK--------LSPSPS-SRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEE 423
GEE R L+P P+ S + R S+++ +S+T G S +K E EE
Sbjct: 402 GEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSST---GLSLKKEEEEEE 454
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 149 bits (376), Expect = 7e-36
Identities = 131/461 (28%), Positives = 222/461 (48%), Gaps = 68/461 (14%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R +E+E+++ LN++ A +ID+VR LE +N L K + +E +R V ++ L++S +
Sbjct: 146 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTS 205
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR L+ ER RL+ E+ ++ D V + E E+
Sbjct: 206 ELRRQLESITTERGRLEAELRNMQ---DVVEDFKVRYEDEI------------------- 243
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
+KR AE+ KK ++ + +V+LE + +SL EE++F
Sbjct: 244 -------NKR-------------TAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINF 283
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
SVF+ E+ + T+ ++ +D++R + D +A E+++Q+++ + E E
Sbjct: 284 IHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIA----EVKAQYEDIANRSRAEAE 339
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K + ++++ ++ ++E+ E ++ L ++ ++KQ S+ + I + E
Sbjct: 340 SWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAE 399
Query: 320 EAMAGE---RDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376
+ GE +D K++D +E +D M + L EYQEL+++KLALD+EI YRKLLE
Sbjct: 400 QR--GELALKDARAKLVDLEEALQKAKQD-MARLLREYQELMNIKLALDVEIATYRKLLE 456
Query: 377 GEEERLK---LSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLG 433
GEE RL +SP S VT + ++ SGS G LG SG LG
Sbjct: 457 GEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTT---SGGHSLG 513
Query: 434 TGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDK 474
G GGS GF GS S KFV ++S K
Sbjct: 514 AGLGGS-GFSATSNRGLGGSGS------SVKFVSTTSSSQK 547
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 148 bits (373), Expect = 2e-35
Identities = 113/398 (28%), Positives = 189/398 (47%), Gaps = 60/398 (15%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTR----EVSGIKALYES 78
R QEK +L++LNDR A +I+RV LE +N K+ E E + R E S +ALYE
Sbjct: 87 RTQEKAQLQDLNDRFASFIERVHELEQQN-----KVLEAELLVLRQKHSEPSRFRALYEQ 141
Query: 79 ELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHR 138
E+ D R ++ E+ L QG + LE
Sbjct: 142 EIRDLRLAAEDATNEKQAL----------------------------QGEREGLEETLRN 173
Query: 139 SEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEE 198
+ + + E + E A+K ++ L R +LE R SL +E
Sbjct: 174 LQARYEEEVLSREDAEGRLME--------------ARKGADEAALARAELEKRIDSLMDE 219
Query: 199 LDFRKSVFEEEVRETRRR--HERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKL 256
+ F K V EEE+ E + + + + VE+D ++ ++ AL+++R+Q+++
Sbjct: 220 ISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPD-----LSAALKDIRAQYEKLAAKNMQ 274
Query: 257 ELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIR 316
E+ ++++ S+ +N A AA++E+ E+R L++ + ++ + A E +++
Sbjct: 275 NAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQ 334
Query: 317 ELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376
ELE+ + + ++ E E+ + M + L EYQ+LL+VK+ALD+EI AYRKLLE
Sbjct: 335 ELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLE 394
Query: 377 GEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRS 414
GEE RL + S +T + SS SA G L S
Sbjct: 395 GEETRLSFTSVGS--ITSGYSQSSQVFGRSAYGGLQTS 430
Score = 33.1 bits (74), Expect = 0.75
Identities = 70/348 (20%), Positives = 134/348 (38%), Gaps = 52/348 (14%)
Query: 21 LSRLQEKEELRELNDRLAHY--IDRVRALELENDRLLLKISEKEEVTTREVSG----IKA 74
L+R + ++ + L D ++ + EL+ +IS + +VT ++S I+A
Sbjct: 204 LARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRA 263
Query: 75 LYESELADARRVLDETARERARLQIEIGK-----LRAELDEVNKSA---KKREGELTVAQ 126
YE A + +E + R + E +RA DEV++S K + E+ +
Sbjct: 264 QYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACR 323
Query: 127 GRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRV 186
G + LE L DK+ +D++ ++ + K E+ K ++ +
Sbjct: 324 GMNEALEKQLQE--------LEDKQN--ADISAMQDTINKLENELRTTKSEMARYLKEYQ 373
Query: 187 DLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALE----- 241
DL N +L E+ + + E E + S Q + L+
Sbjct: 374 DLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYL 433
Query: 242 ----ELRSQHDEQVRLYKLELEQTYQA-KLDSAK--------LSSDQNDKAAS------- 281
S + V+ ++E+E+T +A K + AK ++ DK +
Sbjct: 434 MSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAE 493
Query: 282 ---AAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGER 326
AA+EE +EA+ E + K+A E ++ E A ++
Sbjct: 494 EEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKK 541
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 147 bits (372), Expect = 2e-35
Identities = 118/445 (26%), Positives = 209/445 (46%), Gaps = 59/445 (13%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELAD 82
R QEKE+++ LN++ A +ID+VR LE +N L K S ++ T S + ++ES + +
Sbjct: 88 RTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTAR-SNMDNMFESYINN 146
Query: 83 ARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVE 142
RR L+ +E+ +L+ E+G + QG V+D ++ +
Sbjct: 147 LRRQLETLGQEKLKLEAELGNM---------------------QGLVEDFKNKYE----- 180
Query: 143 LAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFR 202
D R ++ E+ + KK +++ + +V+LE+R + L +E++F
Sbjct: 181 -------------DEINKRTEM---ENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFL 224
Query: 203 KSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTY 262
+ ++EEE+RE + + V + + D M + E+++Q+++ + E E Y
Sbjct: 225 RQLYEEEIRELQSQISDTSVVLSMDNSRSLD--MDSIIAEVKAQYEDIANRSRAEAESMY 282
Query: 263 QAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAM 322
Q K + + + ++ + E+ E + L ++ GL+ Q ++ E I + E+
Sbjct: 283 QIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRG 342
Query: 323 AGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERL 382
L E + + M +QL EYQEL++VKLALD+EI YRKLLEGEE RL
Sbjct: 343 ELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRL 402
Query: 383 KLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGF 442
+ S T + TS +G LS+ G L LG+ G G
Sbjct: 403 ESGMQNMSIHT--KTTSGYAGGLSSA--YGGLTSPGLSYS---------LGSSFGSGAGS 449
Query: 443 HLAQQASASGSVSIEEIDL-EGKFV 466
+ S+S +V +++I+ +GK V
Sbjct: 450 SSFSRTSSSRAVVVKKIETRDGKLV 474
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 144 bits (363), Expect = 2e-34
Identities = 107/371 (28%), Positives = 186/371 (50%), Gaps = 45/371 (12%)
Query: 11 GPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVS 70
G + P +LSR EKE+L+ LNDR A YI++V LE +N + +I +
Sbjct: 86 GGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQ 145
Query: 71 GIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVK 130
+ Y+ E+ + R L+ E+A++Q++ L +
Sbjct: 146 -LGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLE------------------------E 180
Query: 131 DLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLEN 190
D+ L R E E A L D E+ + LR K +E+ +L++V+L+
Sbjct: 181 DIHRLKERFEEE--ARLRDDT--EAAIRALR--------------KDIEEASLVKVELDK 222
Query: 191 RCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQ 250
+ QSLQ+E+ F +S EEEV + + + + V+ + D ++ AL+E+RSQ +
Sbjct: 223 KVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTD--ISTALKEIRSQLESH 280
Query: 251 VRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASA 310
+ E+ ++ + +++QN +A +A+EE+ E R +L+S S +L ++ +
Sbjct: 281 SDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKES 340
Query: 311 AEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINA 370
E ++ ++EE + ++ + E E+ + M + L EYQ+LL+VK+ALD+EI A
Sbjct: 341 LERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAA 400
Query: 371 YRKLLEGEEER 381
YRKLLEGEE R
Sbjct: 401 YRKLLEGEETR 411
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 143 bits (361), Expect = 4e-34
Identities = 123/441 (27%), Positives = 213/441 (48%), Gaps = 71/441 (16%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISE-KEEVTTREVSGIKALYESELA 81
R +E+E+++ LN++ A +ID+V+ LE +N L K + +++ TT ++ L+E+ L+
Sbjct: 208 RTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLS 267
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
R+ LD ++ RLQ EL Q V+D ++ +
Sbjct: 268 VLRKQLDTLGNDKGRLQ---------------------SELKTMQDSVEDFKTKYEE--- 303
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E+ + A AE+ V KK ++ L +V+LE + SL +E++F
Sbjct: 304 -----------------EINKRTA-AENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINF 345
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
K +++ E+ + T ++ +D++R + D +A E+R+Q++E + K E E
Sbjct: 346 LKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIA----EVRAQYEEIAQRSKAEAE 401
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K+ ++S DQ+ + E+ E ++ L ++ ++KQ + + + E
Sbjct: 402 ALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAE 461
Query: 320 EAMAGE---RDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE 376
+ GE +D K ++ E + + ++ + + L EYQEL+ VKLALD+EI YRKLLE
Sbjct: 462 QR--GENALKDAHSKRVEL-EAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLE 518
Query: 377 GEEERLKLSPSPSSRVTVSRAT-SSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTG 435
GEE R +S S V++S + S+S+G +S G LG G G S G G
Sbjct: 519 GEEYR--MSGECQSAVSISVVSGSTSTGGIS--GGLGSGS----------GFGLS-SGFG 563
Query: 436 TGGSGGFHLAQQASASGSVSI 456
+G GF S S S I
Sbjct: 564 SGSGSGFGFGGSVSGSSSSKI 584
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 142 bits (358), Expect = 9e-34
Identities = 106/420 (25%), Positives = 206/420 (49%), Gaps = 53/420 (12%)
Query: 25 QEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEV-TTREVSGIKALYESELADA 83
+E+E+++ LN++ A +ID+VR LE +N L K ++V T+ ++ +ES + +
Sbjct: 179 REREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNL 238
Query: 84 RRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVEL 143
RR +D+ +++RL E+ ++ D V K E E+
Sbjct: 239 RRRVDQLKSDQSRLDSELKNMQ---DMVEDYRNKYEDEI--------------------- 274
Query: 144 AAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRK 203
+KR AE+ KK ++ + +VDL+ + +LQ+E+DF
Sbjct: 275 -----NKR-------------TNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLT 316
Query: 204 SVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQT 261
++++ E+ + T+ ++ +D++R + D +A E+++Q+++ + K E E
Sbjct: 317 ALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIA----EVKAQYEDIAQKSKAEAESL 372
Query: 262 YQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEA 321
YQ+K + ++++ ++ + ++ E+ E ++ L ++ ++KQ S + I + E+
Sbjct: 373 YQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQR 432
Query: 322 MAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEER 381
+ L+ E + + ++ + + L +YQEL++ KLALD+EI YR LLEGEE R
Sbjct: 433 GENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESR 492
Query: 382 LKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGG 441
+ +P+ V+VS + ++ SG S G G GSG G+G GG GG
Sbjct: 493 MSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYG----SGGSSYGSGGGSYGSGGGGGGG 548
>gi|47132620 keratin 2 [Homo sapiens]
Length = 639
Score = 141 bits (356), Expect = 1e-33
Identities = 110/429 (25%), Positives = 210/429 (48%), Gaps = 59/429 (13%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLK--ISEKEEVTTREVSGIKALYESEL 80
+ QE+E+++ LN++ A +ID+VR LE +N L K + ++ V TR ++ ++ +++ +
Sbjct: 175 KAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPIN-LEPIFQGYI 233
Query: 81 ADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSE 140
+R LD ER E+ ++ D V KK E E+
Sbjct: 234 DSLKRYLDGLTAERTSQNSELNNMQ---DLVEDYKKKYEDEI------------------ 272
Query: 141 VELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELD 200
+KR AE+ KK ++ +++V+L+++ L +E++
Sbjct: 273 --------NKR-------------TAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIE 311
Query: 201 FRKSVFEEEVRETRRR--HERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLEL 258
F K +++ E+ + + ++ +D+SR + D +A E+++Q++E + K E
Sbjct: 312 FLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIA----EVKAQYEEIAQRSKEEA 367
Query: 259 EQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIREL 318
E Y +K + +++ ++ + + E+ E ++ L +++ ++KQ +D I +
Sbjct: 368 EALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADA 427
Query: 319 EEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGE 378
E+ R L+ E+ + + ++ + + L +YQEL++VKLALD+EI YRKLLEGE
Sbjct: 428 EQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGE 487
Query: 379 EERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTG--- 435
E ++S SS VTVS +S+ S ++++ G S + SG S G+G
Sbjct: 488 E--CRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQ 545
Query: 436 ---TGGSGG 441
GGSGG
Sbjct: 546 SGSRGGSGG 554
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 138 bits (347), Expect = 2e-32
Identities = 115/439 (26%), Positives = 212/439 (48%), Gaps = 64/439 (14%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R +E+E+++ LN++ A +ID+VR LE +N L K + +E T+ V ++ L+E +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR LD ER RL + EL Q V+DL++ +
Sbjct: 220 NLRRQLDSIVGERGRL---------------------DSELRNMQDLVEDLKNKY----- 253
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E ++ + A AE+ KK ++ + +V+L+ + +L +E++F
Sbjct: 254 ------------EDEINKRTA----AENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
+++++ E+ + T ++ +D++R + D +A E+++Q++E + + E E
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIAQRSRAEAE 353
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K + ++++ ++ ++E+ E ++ L ++ ++KQ ++ + I + E
Sbjct: 354 SWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAE 413
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ + L+ E + + + + + L EYQEL++VKLALD+EI YRKLLEGEE
Sbjct: 414 QRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEE 473
Query: 380 ERLKLSPSPSSRVTVSRAT-SSSSGSLSATGR-LGRSKRKRLEVEEPLGSGPSV-LGTGT 436
RL V+V ++T SS G S G LG LG G S G+G
Sbjct: 474 CRLNGEGVGQVNVSVVQSTISSGYGGASGVGSGLG------------LGGGSSYSYGSGL 521
Query: 437 GGSGGFHLAQQASASGSVS 455
G GGF + + G +S
Sbjct: 522 GIGGGFSSSSGRAIGGGLS 540
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 137 bits (346), Expect = 2e-32
Identities = 122/440 (27%), Positives = 208/440 (47%), Gaps = 68/440 (15%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R +E+E+++ LN++ A +ID+VR LE +N L K + +E T+ V ++ L+E +
Sbjct: 165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 224
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR LD ER RL E+ ++ D V K E E+
Sbjct: 225 NLRRQLDSIVGERGRLDSELRNMQ---DLVEDFKNKYEDEI------------------- 262
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
+KR AE+ + KK ++ + +V+LE + +L +E++F
Sbjct: 263 -------NKR-------------TTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINF 302
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
K F+ E+ + T ++ +D++R + D +A E+++Q++E + E E
Sbjct: 303 MKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIANRSRTEAE 358
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K + + ++ ++ + E+ E ++ L ++ ++KQ + ++ I + E
Sbjct: 359 SWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAE 418
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ R L E+ + + + M + L EYQEL++ KLALD+EI YRKLLEGEE
Sbjct: 419 QRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEE 478
Query: 380 ERLKLSPSPSSRVTVSRATSS-SSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGG 438
+LS V +S TSS SSG S +G G LG G LG G GG
Sbjct: 479 --CRLSGEGVGPVNISVVTSSVSSGYGSGSGYGG-----------GLGGG---LGGGLGG 522
Query: 439 --SGGFHLAQQASASGSVSI 456
+GG + +S+SG V +
Sbjct: 523 GLAGGSSGSYYSSSSGGVGL 542
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 137 bits (346), Expect = 2e-32
Identities = 114/439 (25%), Positives = 211/439 (48%), Gaps = 64/439 (14%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R +E+E+++ LN++ A +ID+VR LE +N L K + +E T+ V ++ L+E +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR LD ER RL + EL Q V+DL++ +
Sbjct: 220 NLRRQLDNIVGERGRL---------------------DSELRNMQDLVEDLKNKY----- 253
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E ++ + A AE+ KK ++ + +V+L+ + +L +E++F
Sbjct: 254 ------------EDEINKRTA----AENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
+++++ E+ + T ++ +D++R + D +A E+++Q++E + + E E
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIAQRSRAEAE 353
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K + ++++ ++ ++E+ E ++ L ++ ++KQ + + I + E
Sbjct: 354 SWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAE 413
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ + L+ E + + + + + L EYQEL++VKLALD+EI YRKLLEGEE
Sbjct: 414 QRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEE 473
Query: 380 ERLKLSPSPSSRVTVSRAT-SSSSGSLSATGR-LGRSKRKRLEVEEPLGSGPSV-LGTGT 436
RL ++V ++T SS G S G LG LG G S G+G
Sbjct: 474 CRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLG------------LGGGSSYSYGSGL 521
Query: 437 GGSGGFHLAQQASASGSVS 455
G GGF + + G +S
Sbjct: 522 GVGGGFSSSSGRATGGGLS 540
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 137 bits (344), Expect = 4e-32
Identities = 111/405 (27%), Positives = 190/405 (46%), Gaps = 58/405 (14%)
Query: 16 LSPTRLS--------RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTR 67
L+P RL R +E E+++ LN++ A +ID+VR LE +N L K + +E +
Sbjct: 73 LAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSA 132
Query: 68 EVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQG 127
+ S + ++E+++A R L+ + RL+ E LR+ D V K E E+
Sbjct: 133 KSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAE---LRSMQDVVEDFKNKYEDEIN---- 185
Query: 128 RVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVD 187
HR+ AE+ V KK ++ + +V+
Sbjct: 186 ---------HRTA--------------------------AENEFVVLKKDVDAAYMSKVE 210
Query: 188 LENRCQSLQEELDFRKSVFEEEVRETRRRHERRLV--EVDSSRQQEYDFKMAQALEELRS 245
LE + +L +E++F +++ E E+ E + + V +D+SR + D +A E+++
Sbjct: 211 LEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIA----EVKA 266
Query: 246 QHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQ 305
Q++E + + E E YQ K ++ + + ++ R E+ E ++ L ++ ++
Sbjct: 267 QYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIK 326
Query: 306 KQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALD 365
Q + E I E EE R + E + + M +QL EYQEL+ VKLALD
Sbjct: 327 NQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALD 386
Query: 366 MEINAYRKLLEGEEERLKLSPSPSSRVTVSRAT--SSSSGSLSAT 408
+EI YRKLLEGEE RL + ++V +T SSS G + T
Sbjct: 387 IEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSSSGGGIGLT 431
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 137 bits (344), Expect = 4e-32
Identities = 116/439 (26%), Positives = 207/439 (47%), Gaps = 64/439 (14%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R +E+E+++ LN++ A +ID+VR LE +N L K + +E T+ V ++ L+E +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ RR LD ER RL E LR D V K E E+
Sbjct: 220 NLRRQLDSIVGERGRLDSE---LRGMQDLVEDFKNKYEDEI------------------- 257
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
+KR AE+ KK ++ + +V+L+ + +L +E++F
Sbjct: 258 -------NKR-------------TAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
+++++ E+ + T ++ +D++R + D +A E+++Q++E + + E E
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIAQRSRAEAE 353
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K + ++++ ++ ++E+ E ++ L ++ ++KQ + + I + E
Sbjct: 354 SWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAE 413
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ + L+ E + + + + + L EYQEL++VKLALD+EI YRKLLEGEE
Sbjct: 414 QRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEE 473
Query: 380 ERLKLSPSPSSRVTVSRAT-SSSSGSLSATGR-LGRSKRKRLEVEEPLGSGPSV-LGTGT 436
RL ++V ++T SS G S G LG LG G S G+G
Sbjct: 474 CRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLG------------LGGGSSYSYGSGL 521
Query: 437 GGSGGFHLAQQASASGSVS 455
G GGF + + G +S
Sbjct: 522 GVGGGFSSSSGRAIGGGLS 540
>gi|15618995 keratin 71 [Homo sapiens]
Length = 523
Score = 136 bits (343), Expect = 5e-32
Identities = 110/434 (25%), Positives = 199/434 (45%), Gaps = 71/434 (16%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREV-SGIKALYESELA 81
R QE+E+++ LN++ A +ID+VR LE +N L K +++ + ++ + E ++
Sbjct: 127 RAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYIS 186
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ R+ L+ + +R RL E+ +R D V K+ E E+
Sbjct: 187 NLRKQLETLSGDRVRLDSELRNVR---DVVEDYKKRYEEEI------------------- 224
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
+KR AE+ + KK ++ +V+L+ + +S+ +E+ F
Sbjct: 225 -------NKR-------------TAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKF 264
Query: 202 RKSVFEEEVRETRRRHERR--LVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
+ +FE E+ + + ++ +D++R + D ++E+R+Q++E K E E
Sbjct: 265 FRCLFEAEITQIQSHISDMSVILSMDNNRNLDLD----SIIDEVRTQYEEIALKSKAEAE 320
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K +L++ ++ + E+ E ++ + ++ ++KQAS E I + E
Sbjct: 321 ALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAE 380
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ R LD E + + ++ + + L EYQEL+ +KLALDMEI YRKLLE EE
Sbjct: 381 QRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEE 440
Query: 380 ERLKLS-PSPSSRVTVSRATSSS---------------------SGSLSATGRLGRSKRK 417
R+ PSP S +S + S SG S G GRS+
Sbjct: 441 CRMSGEFPSPVSISIISSTSGGSVYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGS 500
Query: 418 RLEVEEPLGSGPSV 431
+ ++ LG G S+
Sbjct: 501 ANDYKDTLGKGSSL 514
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 135 bits (339), Expect = 1e-31
Identities = 106/382 (27%), Positives = 181/382 (47%), Gaps = 54/382 (14%)
Query: 26 EKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARR 85
EKE+++ LN++ A +ID+VR LE +N L K S +E S ++ L+ES + + RR
Sbjct: 165 EKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIR-SNLEPLFESYITNLRR 223
Query: 86 VLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAA 145
L+ ++ARLQ E R L +V + KK+ E V +
Sbjct: 224 QLEVLVSDQARLQAE----RNHLQDVLEGFKKKYEEEVVCR------------------- 260
Query: 146 ALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSV 205
A AE+ KK ++ + + DLE +L +E+DF K++
Sbjct: 261 -------------------ANAENEFVALKKDVDAAFMNKSDLEANVDTLTQEIDFLKTL 301
Query: 206 FEEEVR--ETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQ 263
+ EE++ ++ +V++D+SR D + + E+++Q++E R + + E YQ
Sbjct: 302 YMEEIQLLQSHISETSVIVKMDNSR----DLNLDGIIAEVKAQYEEVARRSRADAEAWYQ 357
Query: 264 AKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMA 323
K + ++++ Q+ R E+ E ++ L ++ + Q + E + E E+
Sbjct: 358 TKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAVAEAEQQGE 417
Query: 324 GERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLK 383
+ L E + + + M +QL EYQEL++ KL LD+EI YR+LLEGEE RL
Sbjct: 418 ATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLLEGEESRLC 477
Query: 384 LSPSPSSRVTVSRATSSSSGSL 405
P V+ + SSS G L
Sbjct: 478 EGVGP-----VNISVSSSRGGL 494
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 134 bits (338), Expect = 2e-31
Identities = 113/423 (26%), Positives = 195/423 (46%), Gaps = 50/423 (11%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSG---IKALYESE 79
+ QE+E+++ LN++ A +ID+VR LE +N L K + ++ T +SG ++ L+E+
Sbjct: 195 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENH 254
Query: 80 LADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRS 139
+ R LD ER RL E+ + D V KK E E+
Sbjct: 255 INYLRSYLDNILGERGRLDSELKNME---DLVEDFKKKYEDEI----------------- 294
Query: 140 EVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEEL 199
+KR AE+ KK ++ + +V+L+ + +L +E+
Sbjct: 295 ---------NKR-------------TAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEI 332
Query: 200 DFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
DF +++++ E+ + + V + + D + + E+R+Q+++ + K E E
Sbjct: 333 DFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLD--LDSIIAEVRAQYEDIAQRSKAEAE 390
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ KL + ++ ++ + E+ E ++ L ++ G++KQ + + I E E
Sbjct: 391 ALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAE 450
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ L + + + +D + + L +YQEL++VKLALD+EI YRKLLEGEE
Sbjct: 451 QHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEE 510
Query: 380 ERLK-LSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGG 438
R+ PS S VS +T+S+S G G L G G S G G GG
Sbjct: 511 YRMSGECPSAVSISVVSSSTTSASAG-GYGGGYGGGMGGGLGGGFSAGGG-SGSGFGRGG 568
Query: 439 SGG 441
GG
Sbjct: 569 GGG 571
>gi|148612803 keratin 6 irs4 [Homo sapiens]
Length = 529
Score = 134 bits (336), Expect = 3e-31
Identities = 101/382 (26%), Positives = 185/382 (48%), Gaps = 51/382 (13%)
Query: 23 RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVS-GIKALYESELA 81
R QE+E+++ LND+ A +ID+VR LE +N L K +++ ++ + E ++
Sbjct: 137 RAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYIS 196
Query: 82 DARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEV 141
+ R+ L+ + +R RL E+ +R +++ K R EV
Sbjct: 197 NLRKQLETLSGDRVRLDSELRSMRDLVEDYKK------------------------RYEV 232
Query: 142 ELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDF 201
E+ + AE+ V KK + ++V+L+ + SL +E+ F
Sbjct: 233 EINRRTT------------------AENEFVVLKKDADAAYAVKVELQAKVDSLDKEIKF 274
Query: 202 RKSVFEEEVRE--TRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELE 259
K +++ E+ + T ++ +D++R + D +A E+R ++E K E E
Sbjct: 275 LKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIA----EVRMHYEEIALKSKAEAE 330
Query: 260 QTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELE 319
YQ K+ +L++ ++ R E+ E ++ + ++ ++KQ ++ E I + E
Sbjct: 331 ALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAE 390
Query: 320 EAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEE 379
+ + LD E + + ++ + + L EYQEL+ +KLALDMEI YRKLLEGEE
Sbjct: 391 QRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEE 450
Query: 380 ERLKLSPSPSSRVTVSRATSSS 401
R+ +PSS V++S +SSS
Sbjct: 451 CRMS-GENPSS-VSISVISSSS 470
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 132 bits (333), Expect = 7e-31
Identities = 111/389 (28%), Positives = 179/389 (46%), Gaps = 55/389 (14%)
Query: 9 AGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
+ GP + SR EKE+L+ LNDR A YID+VR LE N L E E R+
Sbjct: 81 SNGPEGCMVAVATSR-SEKEQLQALNDRFAGYIDKVRQLEAHNRSL-----EGEAAALRQ 134
Query: 69 V----SGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTV 124
S + LYE E+ + R + R +L++E L ++ V +
Sbjct: 135 QQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQ----------- 183
Query: 125 AQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLM 184
R+ D R E E AA + E++ A
Sbjct: 184 ---RLDD--EARQREEAEAAARALARFAQEAEAA-------------------------- 212
Query: 185 RVDLENRCQSLQEELDFRKSVFEEEVRETRRRHE---RRLVEVDSSRQQEYDFKMAQALE 241
RVDL+ + Q+LQEE + + +EEV E + + ++ + + + AL
Sbjct: 213 RVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
Query: 242 ELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQL 301
E+R+Q + L+ E+ ++ +LD ++ N A +A+EE+ E R +L++ + +L
Sbjct: 273 EIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
Query: 302 SGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVK 361
L+ + E + ELE+ + +++ + + E+ + M QL EYQ+LL+VK
Sbjct: 333 EALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVK 392
Query: 362 LALDMEINAYRKLLEGEEERLKLSPSPSS 390
+ALD+EI AYRKLLEGEE R+ P P S
Sbjct: 393 MALDIEIAAYRKLLEGEECRIGFGPIPFS 421
Score = 42.0 bits (97), Expect = 0.002
Identities = 115/482 (23%), Positives = 182/482 (37%), Gaps = 122/482 (25%)
Query: 128 RVKDLESLFHRSEVELAAALSDKRG-------LESDVAELRAQLAKAEDGHAVAKKQLEK 180
+V+ LE+ E E AA + G E +V E+R + + G A + +LE+
Sbjct: 114 KVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRL--GAARGQLRLEQ 171
Query: 181 ETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQAL 240
E L+ D+ + Q L +E R EE R R E +++R K AQAL
Sbjct: 172 EHLLE-DIAHVRQRLDDEARQR-----EEAEAAARALARFAQEAEAARVDLQ--KKAQAL 223
Query: 241 EE----LRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLES 296
+E LR H E+V +++ + A+ A++ ++ D L+E R +LE
Sbjct: 224 QEECGYLRRHHQEEVGELLGQIQGSGAAQ---AQMQAETRDALKCDVTSALREIRAQLEG 280
Query: 297 LSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQE 356
+ Q S LQ + + FR LD ++E V + QE
Sbjct: 281 HAVQ-STLQSE-------------------EWFRVRLD----RLSEAAKVNTDAMRSAQE 316
Query: 357 LLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKR 416
EI YR+ L+ +R T A S+ SL +R
Sbjct: 317 ----------EITEYRRQLQ-------------ARTTELEALKSTKDSL---------ER 344
Query: 417 KRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQ 476
+R E+E+ H A AS ++ + +L ++ + Q
Sbjct: 345 QRSELEDR------------------HQADIASYQEAIQQLDAELRNTKWEMAAQLREYQ 386
Query: 477 SLGNWRIK--------RQVLEGEEIAYKFTP-KYILRAG-QMVTVWAAGAGVAHSPPSTL 526
L N ++ R++LEGEE F P + L G + + V +
Sbjct: 387 DLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKV 446
Query: 527 VWKGQSSWGTGESFRTVLVNADGEEVAMR---TVKKSSVMRENENGEEE---EEEAEFGE 580
V K + TV+V EE + T ++ +E E EEE EEEAE GE
Sbjct: 447 VEKSEKE--------TVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 581 ED 582
E+
Sbjct: 499 EE 500
Score = 34.3 bits (77), Expect = 0.34
Identities = 67/345 (19%), Positives = 133/345 (38%), Gaps = 16/345 (4%)
Query: 10 GGPATPLSPTRLS-RLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
G P P T + + +EK ++ E +++ ++ + E ++ +++E+EE +E
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE----QTEETQVTEEVTEEEEKEAKE 480
Query: 69 VSGIKALYESELADARRVLDET----ARERARLQIEIGKLRAELDEVNKSAKKREGELTV 124
G K E +A +ET A E A + E E + AK E E
Sbjct: 481 EEG-KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK 539
Query: 125 AQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLM 184
+ VK E ++ E A + + + E + A+ A++ E + AK++ +
Sbjct: 540 SPAEVKSPEKAKSPAKEE-AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 185 RVDLENRCQSLQEELDF---RKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALE 241
+ E ++EE KS +EE + + + + + K +
Sbjct: 599 KSP-EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 242 ELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQL 301
E ++ K E + +AK K + +KA S +EE K + +
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716
Query: 302 SGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDV 346
+K S ++ + E+A + +++ + AK E + DV
Sbjct: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
>gi|40354195 keratin 18 [Homo sapiens]
Length = 430
Score = 131 bits (330), Expect = 2e-30
Identities = 110/378 (29%), Positives = 183/378 (48%), Gaps = 51/378 (13%)
Query: 26 EKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARR 85
EKE ++ LNDRLA Y+DRVR+LE EN RL KI E E +V + Y + D R
Sbjct: 80 EKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRD-WSHYFKIIEDLRA 138
Query: 86 VLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAA 145
+ + AR+ ++I R D+ RVK E ELA
Sbjct: 139 QIFANTVDNARIVLQIDNARLAADDF----------------RVK--------YETELAM 174
Query: 146 ALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSV 205
++ +E+D+ LR K ++ + R+ LE ++L+EEL F K
Sbjct: 175 ----RQSVENDIHGLR--------------KVIDDTNITRLQLETEIEALKEELLFMKKN 216
Query: 206 FEEEVR--ETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQ 263
EEEV+ + + VEVD+ + Q+ +A+ + ++R+Q+DE R + EL++ +
Sbjct: 217 HEEEVKGLQAQIASSGLTVEVDAPKSQD----LAKIMADIRAQYDELARKNREELDKYWS 272
Query: 264 AKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMA 323
+++ + AA L E R ++SL L ++ ++ E+ +RE+E A
Sbjct: 273 QQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYA 332
Query: 324 GERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE-GEEERL 382
+ ++ +L E E+ + R Q+Q EY+ LL++K+ L+ EI YR+LLE GE+ L
Sbjct: 333 LQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNL 392
Query: 383 -KLSPSPSSRVTVSRATS 399
S +S T+ + T+
Sbjct: 393 GDALDSSNSMQTIQKTTT 410
>gi|4557888 keratin 18 [Homo sapiens]
Length = 430
Score = 131 bits (330), Expect = 2e-30
Identities = 110/378 (29%), Positives = 183/378 (48%), Gaps = 51/378 (13%)
Query: 26 EKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARR 85
EKE ++ LNDRLA Y+DRVR+LE EN RL KI E E +V + Y + D R
Sbjct: 80 EKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRD-WSHYFKIIEDLRA 138
Query: 86 VLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAA 145
+ + AR+ ++I R D+ RVK E ELA
Sbjct: 139 QIFANTVDNARIVLQIDNARLAADDF----------------RVK--------YETELAM 174
Query: 146 ALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSV 205
++ +E+D+ LR K ++ + R+ LE ++L+EEL F K
Sbjct: 175 ----RQSVENDIHGLR--------------KVIDDTNITRLQLETEIEALKEELLFMKKN 216
Query: 206 FEEEVR--ETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQ 263
EEEV+ + + VEVD+ + Q+ +A+ + ++R+Q+DE R + EL++ +
Sbjct: 217 HEEEVKGLQAQIASSGLTVEVDAPKSQD----LAKIMADIRAQYDELARKNREELDKYWS 272
Query: 264 AKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMA 323
+++ + AA L E R ++SL L ++ ++ E+ +RE+E A
Sbjct: 273 QQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYA 332
Query: 324 GERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLE-GEEERL 382
+ ++ +L E E+ + R Q+Q EY+ LL++K+ L+ EI YR+LLE GE+ L
Sbjct: 333 LQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNL 392
Query: 383 -KLSPSPSSRVTVSRATS 399
S +S T+ + T+
Sbjct: 393 GDALDSSNSMQTIQKTTT 410
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,212,182
Number of Sequences: 37866
Number of extensions: 992019
Number of successful extensions: 13324
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 354
Number of HSP's successfully gapped in prelim test: 919
Number of HSP's that attempted gapping in prelim test: 7434
Number of HSP's gapped (non-prelim): 3830
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.