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Search of human proteins with 27436946
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
(664 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens] 1281 0.0
gi|27436948 lamin A/C isoform 3 [Homo sapiens] 1204 0.0
gi|5031875 lamin A/C isoform 2 [Homo sapiens] 1086 0.0
gi|5031877 lamin B1 [Homo sapiens] 610 e-174
gi|27436951 lamin B2 [Homo sapiens] 601 e-172
gi|55749932 desmin [Homo sapiens] 171 3e-42
gi|21264345 peripherin [Homo sapiens] 166 8e-41
gi|62414289 vimentin [Homo sapiens] 163 4e-40
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 155 9e-38
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 150 3e-36
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 149 8e-36
gi|14249342 internexin neuronal intermediate filament protein, a... 147 2e-35
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 147 3e-35
gi|4504919 keratin 8 [Homo sapiens] 143 4e-34
gi|40354195 keratin 18 [Homo sapiens] 143 6e-34
gi|4557888 keratin 18 [Homo sapiens] 143 6e-34
gi|153791158 keratin 75 [Homo sapiens] 138 1e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 135 1e-31
gi|119395754 keratin 5 [Homo sapiens] 134 2e-31
gi|155969697 keratin 6C [Homo sapiens] 131 2e-30
gi|109148552 keratin 3 [Homo sapiens] 130 3e-30
gi|5031839 keratin 6A [Homo sapiens] 129 9e-30
gi|119703753 keratin 6B [Homo sapiens] 128 1e-29
gi|109255249 keratin 4 [Homo sapiens] 128 2e-29
gi|24430192 keratin 16 [Homo sapiens] 128 2e-29
gi|89357932 keratin 5b [Homo sapiens] 127 4e-29
gi|119395750 keratin 1 [Homo sapiens] 125 1e-28
gi|67782365 keratin 7 [Homo sapiens] 125 2e-28
gi|15431310 keratin 14 [Homo sapiens] 124 3e-28
gi|125628636 keratin 80 isoform a [Homo sapiens] 122 1e-27
>gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
Length = 664
Score = 1281 bits (3314), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR
Sbjct: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
Query: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN
Sbjct: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
Query: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK
Sbjct: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
Query: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR
Sbjct: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
Query: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID
Sbjct: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
Query: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ
Sbjct: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
Query: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK
Sbjct: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
Query: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT
Sbjct: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
Query: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 540
YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM
Sbjct: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 540
Query: 541 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 600
RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA
Sbjct: 541 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 600
Query: 601 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN 660
SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN
Sbjct: 601 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN 660
Query: 661 CSIM 664
CSIM
Sbjct: 661 CSIM 664
>gi|27436948 lamin A/C isoform 3 [Homo sapiens]
Length = 634
Score = 1204 bits (3114), Expect = 0.0
Identities = 634/664 (95%), Positives = 634/664 (95%), Gaps = 30/664 (4%)
Query: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR
Sbjct: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
Query: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN
Sbjct: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
Query: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK
Sbjct: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
Query: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR
Sbjct: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
Query: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID
Sbjct: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
Query: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ
Sbjct: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
Query: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK
Sbjct: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
Query: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT
Sbjct: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
Query: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 540
YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGE
Sbjct: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGE---- 536
Query: 541 RKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 600
GSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA
Sbjct: 537 --------------------------GSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASA 570
Query: 601 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN 660
SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN
Sbjct: 571 SGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQN 630
Query: 661 CSIM 664
CSIM
Sbjct: 631 CSIM 634
>gi|5031875 lamin A/C isoform 2 [Homo sapiens]
Length = 572
Score = 1086 bits (2808), Expect = 0.0
Identities = 567/568 (99%), Positives = 567/568 (99%)
Query: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR
Sbjct: 1 METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLR 60
Query: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN
Sbjct: 61 LRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARN 120
Query: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK
Sbjct: 121 TKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAK 180
Query: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR
Sbjct: 181 KQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESR 240
Query: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID
Sbjct: 241 LADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRID 300
Query: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ
Sbjct: 301 SLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQ 360
Query: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK
Sbjct: 361 ELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK 420
Query: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT
Sbjct: 421 LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLT 480
Query: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 540
YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM
Sbjct: 481 YRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAM 540
Query: 541 RKLVRSVTVVEDDEDEDGDDLLHHHHGS 568
RKLVRSVTVVEDDEDEDGDDLLHHHH S
Sbjct: 541 RKLVRSVTVVEDDEDEDGDDLLHHHHVS 568
>gi|5031877 lamin B1 [Homo sapiens]
Length = 586
Score = 610 bits (1572), Expect = e-174
Identities = 315/570 (55%), Positives = 430/570 (75%), Gaps = 10/570 (1%)
Query: 12 SGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVS 71
S A +TPLSPTR++RLQEKE+L+ELNDRLAVYID+VRSLETEN+ L+L++TE EEV
Sbjct: 13 SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRG 72
Query: 72 REVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQ 131
RE++G+KA YE EL DAR+ LD A+ERA+LQ+EL K + E +L KKE DL AQ
Sbjct: 73 RELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQ 132
Query: 132 ARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRV 191
+L++ EA LNSK+AAL+TAL +K++LEG+L DL+ Q+A+LEA+L AKKQL DE L +V
Sbjct: 133 IKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKV 192
Query: 192 DAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQ 251
D ENR Q++ E+L+F+K++Y EE+ ET+R+HETRLVE+D+G+Q E+E +LA AL E+R Q
Sbjct: 193 DLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQ 252
Query: 252 HEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQK 311
H+ QV YK+ELE+TY AKL+NAR S+E N++ V +A EEL +SR+RI+SLS+QLS LQK
Sbjct: 253 HDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQK 312
Query: 312 QLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDM 371
+ A ++++LED LA+E+D SRR+L +KEREMAE+R +MQQQL++Y++LLD+KLALDM
Sbjct: 313 ESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDM 372
Query: 372 EIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRS--S 429
EI AYRKLLEGEEERL+LSPSP+S+ + RASS S G K+ +E +E+ S S
Sbjct: 373 EISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGK-RKRVDVEESEASSSVS 431
Query: 430 FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTL 489
S A +G V +EE+D +GKF+RL+N S +DQ MG W++ R+ GD ++Y++ ++ L
Sbjct: 432 ISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTS-VSYKYTSRYVL 490
Query: 490 KAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTV 549
KAGQ VTIWAA AG T SPPTDL+WK QN+WG G ++ L NS GEEVA R V T+
Sbjct: 491 KAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTI 550
Query: 550 VEDDEDEDG------DDLLHHHHGSHCSSS 573
E++E+E+ ++ L H G+ +S+
Sbjct: 551 PEEEEEEEEAAGVVVEEELFHQQGTPRASN 580
>gi|27436951 lamin B2 [Homo sapiens]
Length = 600
Score = 601 bits (1549), Expect = e-172
Identities = 315/586 (53%), Positives = 428/586 (73%), Gaps = 26/586 (4%)
Query: 14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSRE 73
A +TPLSPTR++RLQEKE+L+ELNDRLA YIDRVR+LE EN L L+I+E EEV +RE
Sbjct: 9 AGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTRE 68
Query: 74 VSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQAR 133
VSGIKA YE+EL DAR+ LD A+ERARLQ+E+ K+R E E+ K+EG+L AQ R
Sbjct: 69 VSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGR 128
Query: 134 LKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDA 193
+KDLE+L + E L+ ALS+KR LE ++ +LR Q+AK E AKKQL+ E L RVD
Sbjct: 129 VKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDL 188
Query: 194 ENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHE 253
ENR Q+++EELDF+K+++ EE+RET+RRHE RLVE+D+ +Q+E++ ++A AL+ELR+QH+
Sbjct: 189 ENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHD 248
Query: 254 DQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQL 313
+QV YK ELE+TY AKLD+A+ S+++N AA EEL+++R+R++SLS QLS LQKQ
Sbjct: 249 EQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQA 308
Query: 314 AAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEI 373
+A E ++R+LE+++A ERD R++L KE+EM EMR MQQQL EYQELLD+KLALDMEI
Sbjct: 309 SAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEI 368
Query: 374 HAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS---QTQGGGSVTKKRKLESTESRSS- 429
+AYRKLLEGEEERL+LSPSP+S+ + RA+S SS G +K+++LE E S
Sbjct: 369 NAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSG 428
Query: 430 ---------------FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNG 474
+Q A SG V++EE+D EGKFV+L+N S++DQS+GNW+IKRQ
Sbjct: 429 PSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVL 488
Query: 475 DDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINST 534
+ + Y+F PK+ L+AGQ+VT+WAAGAG HSPP+ LVWK Q++WG G S RT L+N+
Sbjct: 489 EGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNAD 548
Query: 535 GEEVAMRKLVRSVTV-------VEDDEDEDGDDLLHHHHGSHCSSS 573
GEEVAMR + +S + E++E E G++ L H G ++S
Sbjct: 549 GEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTS 594
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 171 bits (432), Expect = 3e-42
Identities = 119/398 (29%), Positives = 200/398 (50%), Gaps = 51/398 (12%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELG 86
TR EK +LQELNDR A YI++VR LE +NA L E + RE + + YE EL
Sbjct: 104 TRTNEKVELQELNDRFANYIEKVRFLEQQNAAL---AAEVNRLKGREPTRVAELYEEELR 160
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ ++ + +RAR+ +E + ++ + LKA+
Sbjct: 161 ELRRQVEVLTNQRARVDVERDNLLDDLQRLKAK--------------------------- 193
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
L + K E L R A ++AA L R+D E R++++ EE+ F
Sbjct: 194 -LQEEIQLKEEAENNLAAFR---ADVDAA-----------TLARIDLERRIESLNEEIAF 238
Query: 207 QKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKT 266
K ++ EE+RE + + + + V+++ + L AL+++RAQ+E + E E+
Sbjct: 239 LKKVHEEEIRELQAQLQEQQVQVEMDMSK---PDLTAALRDIRAQYETIAAKNISEAEEW 295
Query: 267 YSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDS 326
Y +K+ + Q+A +N++ + A +E+ + R +I S + ++ L+ + ++R+LED
Sbjct: 296 YKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDR 355
Query: 327 LARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEER 386
A E + +A E E+ ++ M + L EYQ+LL++K+ALD+EI YRKLLEGEE R
Sbjct: 356 FASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESR 415
Query: 387 LRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLEST 424
+ L P S S + +G TKK + T
Sbjct: 416 INL---PIQTYSALNFRETSPEQRGSEVHTKKTVMIKT 450
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 166 bits (419), Expect = 8e-41
Identities = 124/419 (29%), Positives = 210/419 (50%), Gaps = 70/419 (16%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELG 86
TR EK++LQELNDR A +I++VR LE +NA LR ++++ +E + + EL
Sbjct: 93 TRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQAR---GQEPARADQLCQQELR 149
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ L+ + +ER R+Q+E + E DL A + RL++
Sbjct: 150 ELRRELELLGRERDRVQVERDGLAE--------------DLAALKQRLEE---------- 185
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
E R E H+L +K + D L R++ E +++++ +E++F
Sbjct: 186 -------ETRKREDAEHNLV-----------LFRKDVDDATLSRLELERKIESLMDEIEF 227
Query: 207 QKNIYSEELRETKRRHETRLVEIDNGKQREFES----RLADALQELRAQHEDQVEQYKKE 262
K ++ EELR+ + E++ V+ Q E E+ L AL+++RAQ+E + +E
Sbjct: 228 LKKLHEEELRDLQVSVESQQVQ-----QVEVEATVKPELTAALRDIRAQYESIAAKNLQE 282
Query: 263 LEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRD 322
E+ Y +K + +A RN + A +E+ +SR +I SL+ ++ L+ A +LR+
Sbjct: 283 AEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRE 342
Query: 323 LEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEG 382
LE+ A E + A E E+ +++ M + L EYQELL++K+ALD+EI YRKLLEG
Sbjct: 343 LEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEG 402
Query: 383 EEERLRLS----------------PSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTE 425
EE R+ + P SR + +T+ G VT+ +K + +E
Sbjct: 403 EESRISVPVHSFASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSE 461
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 163 bits (413), Expect = 4e-40
Identities = 105/363 (28%), Positives = 192/363 (52%), Gaps = 48/363 (13%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELG 86
TR EK +LQELNDR A YID+VR LE +N ++ + E E++ + S + YE E+
Sbjct: 99 TRTNEKVELQELNDRFANYIDKVRFLEQQN---KILLAELEQLKGQGKSRLGDLYEEEMR 155
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ +D + ++AR+++E + E+ L R K E +L +EA
Sbjct: 156 ELRRQVDQLTNDKARVEVERDNLAEDIMRL----------------REKLQEEMLQREEA 199
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
E L ++ + + L R+D E ++++++EE+ F
Sbjct: 200 --------------------------ENTLQSFRQDVDNASLARLDLERKVESLQEEIAF 233
Query: 207 QKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKT 266
K ++ EE++E + + + + V+ID + L AL+++R Q+E + +E E+
Sbjct: 234 LKKLHEEEIQELQAQIQEQHVQIDVDVSK---PDLTAALRDVRQQYESVAAKNLQEAEEW 290
Query: 267 YSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDS 326
Y +K + ++A RN++ + A +E + R ++ SL+ ++ L+ + E ++R++E++
Sbjct: 291 YKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEEN 350
Query: 327 LARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEER 386
A E + + + E+ M+ M + L EYQ+LL++K+ALD+EI YRKLLEGEE R
Sbjct: 351 FAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESR 410
Query: 387 LRL 389
+ L
Sbjct: 411 ISL 413
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 155 bits (393), Expect = 9e-38
Identities = 125/431 (29%), Positives = 208/431 (48%), Gaps = 63/431 (14%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSR----EVSGIKAAYEA 83
R QEK LQ+LNDR A +I+RV LE +N ++ E+E +V R E S +A YE
Sbjct: 87 RTQEKAQLQDLNDRFASFIERVHELEQQN-----KVLEAELLVLRQKHSEPSRFRALYEQ 141
Query: 84 ELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNS 143
E+ D R + E+ LQ E + E + L+AR ++ A+ RL +EA +
Sbjct: 142 EIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRL--MEARKGA 199
Query: 144 KEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEE 203
EAAL+ A EK R+ ++ +E
Sbjct: 200 DEAALARAELEK----------------------------------------RIDSLMDE 219
Query: 204 LDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKEL 263
+ F K ++ EE+ E + + + + ++ + L+ AL+++RAQ+E + +
Sbjct: 220 ISFLKKVHEEEIAELQAQIQYAQISVEMDVTK---PDLSAALKDIRAQYEKLAAKNMQNA 276
Query: 264 EKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDL 323
E+ + ++ +SA +N++ V AA +E+ +SR + + + ++ + A E +L++L
Sbjct: 277 EEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQEL 336
Query: 324 EDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGE 383
ED + + + + E E+ ++ M + L EYQ+LL++K+ALD+EI AYRKLLEGE
Sbjct: 337 EDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGE 396
Query: 384 EERLRLSPSPTSQRSRGRASSHSSQTQG----GGSVTKKRKLESTESRSSFSQHARTSGR 439
E RL S TS S S SSQ G GG T + + S ++ H + +
Sbjct: 397 ETRL----SFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEE-Q 451
Query: 440 VAVEEVDEEGK 450
+ VEE E K
Sbjct: 452 IEVEETIEAAK 462
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 150 bits (380), Expect = 3e-36
Identities = 114/403 (28%), Positives = 194/403 (48%), Gaps = 53/403 (13%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELG 86
TR E+ ++ ELNDR A YI++VR LE +N L E ++ ++E + + Y+AEL
Sbjct: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALA---AELNQLRAKEPTKLADVYQAELR 121
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ L+L L ++ L+ DL + +L+D L
Sbjct: 122 E--------------LRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNL------ 161
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
LE E + L +++ + L R+D E ++++++EE+ F
Sbjct: 162 ----------RLEAENN------------LAAYRQEADEATLARLDLERKIESLEEEIRF 199
Query: 207 QKNIYSEELRETKRR--HETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
+ I+ EE+RE + + + VE+D K L AL+E+R Q+E E E
Sbjct: 200 LRKIHEEEVRELQEQLARQQVHVELDVAKPD-----LTAALKEIRTQYEAMASSNMHEAE 254
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
+ Y +K + +A RN+ L+ A E R ++ SL+ L L+ + E ++R+ E
Sbjct: 255 EWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQE 314
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
+ RE + + LA E E ++ M + L EYQ+LL++KLALD+EI YRKLLEGEE
Sbjct: 315 ERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEE 374
Query: 385 ERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESR 427
R+ + P T + R +S +++ G + + +++ E R
Sbjct: 375 NRITI-PVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMR 416
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 149 bits (376), Expect = 8e-36
Identities = 98/369 (26%), Positives = 188/369 (50%), Gaps = 45/369 (12%)
Query: 18 STPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGI 77
S P +++R EKE LQ LNDR A YI++V LE +N + I + + +
Sbjct: 88 SGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQ-L 146
Query: 78 KAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL 137
AY+ E+ + R TL+ V E+A++QL+ + E+ LK R +ARL+D
Sbjct: 147 GDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKER--------FEEEARLRD- 197
Query: 138 EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRL 197
EAA+ +K +++ L +V+ + ++
Sbjct: 198 ---------------------------------DTEAAIRALRKDIEEASLVKVELDKKV 224
Query: 198 QTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE 257
Q++++E+ F ++ + EE+ + + + + ++ ++ ++ ++ AL+E+R+Q E +
Sbjct: 225 QSLQDEVAFLRSNHEEEVADLLAQIQASHITVE--RKDYLKTDISTALKEIRSQLESHSD 282
Query: 258 QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE 317
Q + E+ + + ++AE+N + +A EE+ + R ++ S S +L ++ + E
Sbjct: 283 QNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLE 342
Query: 318 AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYR 377
+L D+E+ + + + + + E E+ + M + L EYQ+LL++K+ALD+EI AYR
Sbjct: 343 RQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYR 402
Query: 378 KLLEGEEER 386
KLLEGEE R
Sbjct: 403 KLLEGEETR 411
Score = 40.8 bits (94), Expect = 0.004
Identities = 57/285 (20%), Positives = 114/285 (40%), Gaps = 42/285 (14%)
Query: 11 RSGAQASSTPLSPTRITRLQEKEDLQELNDR----LAVYIDRVRSLETENAGLRLRITES 66
R Q+ S L R T+ + L ++ +R L+ Y D ++ LE E G + +
Sbjct: 321 RRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARH 380
Query: 67 EEVVSREVSGIKAAYEAELGDARKTLD--------------------------SVAKERA 100
+++ +K A + E+ RK L+ S ++
Sbjct: 381 LREY-QDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKP 439
Query: 101 RLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL--EALLNSKEAALSTALSEKRTL 158
+++ KV+ +F E TK E + + L + E ++ KE A ++
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499
Query: 159 EGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET 218
E E ++ + + ++A E K++ ++ + E + +EE + K+ +EE
Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEK-----EEEEGQEEEEEEDEGAKSDQAEEGGSE 554
Query: 219 KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKEL 263
K E + G+Q E E+ +E A+ E +VE+ +E+
Sbjct: 555 KEGSS----EKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 595
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 147 bits (372), Expect = 2e-35
Identities = 126/459 (27%), Positives = 210/459 (45%), Gaps = 74/459 (16%)
Query: 25 RITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAE 84
+I R EKE LQ LNDR AV+I++V LET+N L EAE
Sbjct: 88 KIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRAL----------------------EAE 125
Query: 85 LGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSK 144
L R+ E S+V E F Q L+DL A L
Sbjct: 126 LAALRQR-----------HAEPSRVGELF-----------------QRELRDLRAQLEEA 157
Query: 145 EAALSTALSEKRTLEGELHDLRGQVAK-------LEAALGEAKKQLQDEMLRRVDAENRL 197
+A S AL E+ L E+ LR + + E AL ++ + L R+D E ++
Sbjct: 158 SSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKV 217
Query: 198 QTMKEELDFQKNIYSEELRE---TKRRHETRLVEIDNGKQREFESRLADALQELRAQHED 254
+++ +EL F + ++ EE+ E T + E+D + L AL+E+RAQ+E
Sbjct: 218 ESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKP---DLTSALREIRAQYES 274
Query: 255 QVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLA 314
+ + E+ Y +K N + A R++ + A+ EE+ + R ++ + + ++ L+
Sbjct: 275 LAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANE 334
Query: 315 AKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIH 374
+ E ++ +LE+ + E + + + E ++ ++ M + L EYQ+LL++K+ALD+EI
Sbjct: 335 SLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIA 394
Query: 375 AYRKLLEGEEERLRLS----------PSPTSQRSRGRASSHSSQTQGGGSVTKKRKLEST 424
AYRKLLEGEE R S P+P+ S+ +S+ G KK + E
Sbjct: 395 AYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEE-EEE 453
Query: 425 ESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQS 463
E+ S+ G E ++E + KSN +++
Sbjct: 454 EASKVASKKTSQIGESFEEILEETVISTKKTEKSNIEET 492
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 147 bits (371), Expect = 3e-35
Identities = 107/365 (29%), Positives = 177/365 (48%), Gaps = 52/365 (14%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELG 86
TR E+ ++ ELNDR A YI++VR LE +N L E ++ ++E + + Y+AEL
Sbjct: 65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALA---AELNQLRAKEPTKLADVYQAELR 121
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ L+L L ++ L+ DL + +L+D L
Sbjct: 122 E--------------LRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNL------ 161
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
LE E + L +++ + L R+D E ++++++EE+ F
Sbjct: 162 ----------RLEAENN------------LAAYRQEADEATLARLDLERKIESLEEEIRF 199
Query: 207 QKNIYSEELRETKRR--HETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
+ I+ EE+RE + + + VE+D K L AL+E+R Q+E E E
Sbjct: 200 LRKIHEEEVRELQEQLARQQVHVELDVAKPD-----LTAALKEIRTQYEAMASSNMHEAE 254
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
+ Y +K + +A RN+ L+ A E R ++ SL+ L L+ + E ++R+ E
Sbjct: 255 EWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQE 314
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
+ RE + + LA E E ++ M + L EYQ+LL++KLALD+EI YRKLLEGEE
Sbjct: 315 ERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEE 374
Query: 385 ERLRL 389
R+ +
Sbjct: 375 NRITI 379
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 143 bits (361), Expect = 4e-34
Identities = 117/434 (26%), Positives = 207/434 (47%), Gaps = 56/434 (12%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGD 87
R QEKE ++ LN++ A +ID+VR LE +N L + + ++ +
Sbjct: 88 RTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKT---------------- 131
Query: 88 ARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAA 147
AR +D++ + ++ +R + + L K E +L Q ++D + N E
Sbjct: 132 ARSNMDNM------FESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFK---NKYEDE 182
Query: 148 LSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQ 207
++ KRT ++E KK + + + +V+ E+RL+ + +E++F
Sbjct: 183 IN-----KRT-------------EMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFL 224
Query: 208 KNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEK 265
+ +Y EE+RE + + +T +V +DN + + +S +A E++AQ+ED + + E E
Sbjct: 225 RQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIA----EVKAQYEDIANRSRAEAES 280
Query: 266 TYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLED 325
Y K + + A ++ + + E+ + I L A++ L+ Q A+ EA + D E
Sbjct: 281 MYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQ 340
Query: 326 SLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEE 385
+ L+E E + + M +QL EYQEL+++KLALD+EI YRKLLEGEE
Sbjct: 341 RGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEES 400
Query: 386 RLR-------LSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSG 438
RL + TS + G +S++ T G S + S SSFS+ + +
Sbjct: 401 RLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRA 460
Query: 439 RVAVEEVDEEGKFV 452
V + +GK V
Sbjct: 461 VVVKKIETRDGKLV 474
>gi|40354195 keratin 18 [Homo sapiens]
Length = 430
Score = 143 bits (360), Expect = 6e-34
Identities = 106/357 (29%), Positives = 176/357 (49%), Gaps = 49/357 (13%)
Query: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
EKE +Q LNDRLA Y+DRVRSLETEN L +I E E +V ++ + D R
Sbjct: 80 EKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKI-IEDLRA 138
Query: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
+ + + AR+ L++ R L A R+K T
Sbjct: 139 QIFANTVDNARIVLQIDNAR----------------LAADDFRVK------------YET 170
Query: 151 ALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNI 210
L+ ++++E ++H LR K + D + R+ E ++ +KEEL F K
Sbjct: 171 ELAMRQSVENDIHGLR--------------KVIDDTNITRLQLETEIEALKEELLFMKKN 216
Query: 211 YSEELRETKRRHETR--LVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268
+ EE++ + + + VE+D K ++ LA + ++RAQ+++ + ++EL+K +S
Sbjct: 217 HEEEVKGLQAQIASSGLTVEVDAPKSQD----LAKIMADIRAQYDELARKNREELDKYWS 272
Query: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
+++ + S VGAA L + R + SL L ++ A+ E LR++E A
Sbjct: 273 QQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYA 332
Query: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEE 385
+ + +L E E+A+ RA Q+Q EY+ LL+IK+ L+ EI YR+LLE E+
Sbjct: 333 LQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGED 389
>gi|4557888 keratin 18 [Homo sapiens]
Length = 430
Score = 143 bits (360), Expect = 6e-34
Identities = 106/357 (29%), Positives = 176/357 (49%), Gaps = 49/357 (13%)
Query: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
EKE +Q LNDRLA Y+DRVRSLETEN L +I E E +V ++ + D R
Sbjct: 80 EKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKI-IEDLRA 138
Query: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
+ + + AR+ L++ R L A R+K T
Sbjct: 139 QIFANTVDNARIVLQIDNAR----------------LAADDFRVK------------YET 170
Query: 151 ALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNI 210
L+ ++++E ++H LR K + D + R+ E ++ +KEEL F K
Sbjct: 171 ELAMRQSVENDIHGLR--------------KVIDDTNITRLQLETEIEALKEELLFMKKN 216
Query: 211 YSEELRETKRRHETR--LVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYS 268
+ EE++ + + + VE+D K ++ LA + ++RAQ+++ + ++EL+K +S
Sbjct: 217 HEEEVKGLQAQIASSGLTVEVDAPKSQD----LAKIMADIRAQYDELARKNREELDKYWS 272
Query: 269 AKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
+++ + S VGAA L + R + SL L ++ A+ E LR++E A
Sbjct: 273 QQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYA 332
Query: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEE 385
+ + +L E E+A+ RA Q+Q EY+ LL+IK+ L+ EI YR+LLE E+
Sbjct: 333 LQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGED 389
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 138 bits (348), Expect = 1e-32
Identities = 111/410 (27%), Positives = 201/410 (49%), Gaps = 57/410 (13%)
Query: 15 QASSTPL----SPT-RITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEV 69
Q+ TPL PT + R +E+E ++ LN++ A +ID+VR LE +N L + +E
Sbjct: 128 QSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQ 187
Query: 70 VSREV-SGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLI 128
SR V ++ +++ + R+ L+S+ ER RL+ EL +++ ++ K R
Sbjct: 188 GSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVR--------- 238
Query: 129 AAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEML 188
E +N + AA E E L KK + +
Sbjct: 239 --------YEDEINKRTAA-----------ENEFVAL--------------KKDVDAAYM 265
Query: 189 RRVDAENRLQTMKEELDFQKNIYSEELRE--TKRRHETRLVEIDNGKQREFESRLADALQ 246
+V+ E +++++ EE++F +++ EL + T+ + ++ +DN + + +S +A
Sbjct: 266 NKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIA---- 321
Query: 247 ELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQL 306
E++AQ+ED + + E E Y K + + +A R+ + + +E+ + I L A++
Sbjct: 322 EVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEI 381
Query: 307 SQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIK 366
++KQ ++ + + D E +R L + E + + + M + L EYQEL++IK
Sbjct: 382 DSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIK 441
Query: 367 LALDMEIHAYRKLLEGEEERLR---LSPSPTSQRSRGRASSHSSQTQGGG 413
LALD+EI YRKLLEGEE RL +SP S + +S + S + GG
Sbjct: 442 LALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGG 491
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 135 bits (340), Expect = 1e-31
Identities = 118/462 (25%), Positives = 201/462 (43%), Gaps = 67/462 (14%)
Query: 27 TRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAA----YE 82
T EKE LQ LNDR A YID+VR LE N L E E R+ ++A YE
Sbjct: 93 TSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSL-----EGEAAALRQQQAGRSAMGELYE 147
Query: 83 AELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLN 142
E+ + R + + R +L+LE + E+ ++ R
Sbjct: 148 REVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQR----------------------- 184
Query: 143 SKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKE 202
L D Q + EAA + Q+ RVD + + Q ++E
Sbjct: 185 -------------------LDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQE 225
Query: 203 ELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLAD--------ALQELRAQHED 254
E + + + EE+ E + ++ Q + ++ D AL+E+RAQ E
Sbjct: 226 ECGYLRRHHQEEVGELLGQ-----IQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEG 280
Query: 255 QVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLA 314
Q + E+ + +LD ++A+ N++ + +A EE+ + R ++ + + +L L+
Sbjct: 281 HAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKD 340
Query: 315 AKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIH 374
+ E + +LED + + + + + + E+ + M QL EYQ+LL++K+ALD+EI
Sbjct: 341 SLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIA 400
Query: 375 AYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHA 434
AYRKLLEGEE R+ P P S G S T +K K+ + +
Sbjct: 401 AYRKLLEGEECRIGFGPIPFS-LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE 459
Query: 435 RTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDD 476
+T EEV EE + + E++ G + + + G++
Sbjct: 460 QTEETQVTEEVTEEEEKEAKEEEGKEEE--GGEEEEAEGGEE 499
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 134 bits (338), Expect = 2e-31
Identities = 106/394 (26%), Positives = 190/394 (48%), Gaps = 52/394 (13%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREV-SGIKAAYEAELG 86
R +E+E ++ LN++ A +ID+VR LE +N L + T +E ++ V ++ +E +
Sbjct: 165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 224
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ LDS+ ER RL EL +++ ++ K K E ++
Sbjct: 225 NLRRQLDSIVGERGRLDSELRNMQDLVEDFK---NKYEDEI------------------- 262
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
+++ T E E L KK + + +V+ E ++ + +E++F
Sbjct: 263 ------NKRTTAENEFVML--------------KKDVDAAYMNKVELEAKVDALMDEINF 302
Query: 207 QKNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
K + EL + + +T +V +DN + + +S +A E++AQ+E+ + + E E
Sbjct: 303 MKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIANRSRTEAE 358
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
Y K + +Q+A R+ + + E+ + I L A++ ++KQ A + + D E
Sbjct: 359 SWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAE 418
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
+R LAE E + + + M + L EYQEL++ KLALD+EI YRKLLEGEE
Sbjct: 419 QRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEE 478
Query: 385 ERLR---LSPSPTSQRSRGRASSHSSQTQGGGSV 415
RL + P S + +S + S + GG +
Sbjct: 479 CRLSGEGVGPVNISVVTSSVSSGYGSGSGYGGGL 512
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 131 bits (329), Expect = 2e-30
Identities = 103/390 (26%), Positives = 189/390 (48%), Gaps = 51/390 (13%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREV-SGIKAAYEAELG 86
R +E+E ++ LN++ A +ID+VR LE +N L + T +E ++ V ++ +E +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ LDS+ ER RL EL +++ ++LK + E +N + A
Sbjct: 220 NLRRQLDSIVGERGRLDSELRNMQDLVEDLKNK-----------------YEDEINKRTA 262
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
A E E L KK + + +V+ + + T+ +E++F
Sbjct: 263 A-----------ENEFVTL--------------KKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 207 QKNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
+ +Y EL + + +T +V +DN + + +S +A E++AQ+E+ ++ + E E
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIAQRSRAEAE 353
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
Y K + + +A R+ + + +E+ + I L +++ ++KQ A+ +A + D E
Sbjct: 354 SWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAE 413
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
++ L E + + + + + L EYQEL+++KLALD+EI YRKLLEGEE
Sbjct: 414 QRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEE 473
Query: 385 ERLRLSPSPTSQRSRGRASSHSSQTQGGGS 414
RL+ Q + S S GG S
Sbjct: 474 --CRLNGEGVGQVNVSVVQSTISSGYGGAS 501
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 130 bits (328), Expect = 3e-30
Identities = 103/397 (25%), Positives = 191/397 (48%), Gaps = 66/397 (16%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSG---IKAAYEAE 84
+ QE+E ++ LN++ A +ID+VR LE +N L + ++ + +SG ++ +E
Sbjct: 195 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENH 254
Query: 85 LGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSK 144
+ R LD++ ER RL EL + + ++ K K E +N +
Sbjct: 255 INYLRSYLDNILGERGRLDSELKNMEDLVEDFK-----------------KKYEDEINKR 297
Query: 145 EAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEEL 204
AA E E L KK + + +V+ + ++ + +E+
Sbjct: 298 TAA-----------ENEFVTL--------------KKDVDSAYMNKVELQAKVDALIDEI 332
Query: 205 DFQKNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKE 262
DF + +Y EL + + +T +V +DN + + +S +A E+RAQ+ED ++ K E
Sbjct: 333 DFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIA----EVRAQYEDIAQRSKAE 388
Query: 263 LEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRD 322
E Y KL + +A R+ ++L+ ++ I L+ + +L+ ++ + + +
Sbjct: 389 AEALYQTKLGELQTTAGRHG-------DDLRNTKSEIIELNRMIQRLRAEIEGVKKQNAN 441
Query: 323 LEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDE-------YQELLDIKLALDMEIHA 375
L+ ++A L + ++ E++A +QQ D+ YQEL+++KLALD+EI
Sbjct: 442 LQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIAT 501
Query: 376 YRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGG 412
YRKLLEGEE R+ P++ +SS +S + GG
Sbjct: 502 YRKLLEGEEYRMS-GECPSAVSISVVSSSTTSASAGG 537
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 129 bits (324), Expect = 9e-30
Identities = 108/408 (26%), Positives = 196/408 (48%), Gaps = 56/408 (13%)
Query: 15 QASSTPLS----PT-RITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEV 69
Q+ TPL+ PT + R +E+E ++ LN++ A +ID+VR LE +N L + T +E
Sbjct: 142 QSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQ 201
Query: 70 VSREV-SGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLI 128
++ V ++ +E + + R+ LDS+ ER RL EL +++ ++ K +
Sbjct: 202 GTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNK--------- 252
Query: 129 AAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEML 188
E +N + AA E E L KK + +
Sbjct: 253 --------YEDEINKRTAA-----------ENEFVTL--------------KKDVDAAYM 279
Query: 189 RRVDAENRLQTMKEELDFQKNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQ 246
+V+ + + T+ +E++F + +Y EL + + +T +V +DN + + +S +A
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA---- 335
Query: 247 ELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQL 306
E++AQ+E+ ++ + E E Y K + + +A R+ + + +E+ + I L +++
Sbjct: 336 EVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEI 395
Query: 307 SQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIK 366
++KQ A +A + D E ++ L E + + + + + L EYQEL+++K
Sbjct: 396 DHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVK 455
Query: 367 LALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGS 414
LALD+EI YRKLLEGEE RL+ Q + S S GG S
Sbjct: 456 LALDVEIATYRKLLEGEE--CRLNGEGVGQVNISVVQSTVSSGYGGAS 501
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 128 bits (322), Expect = 1e-29
Identities = 102/390 (26%), Positives = 188/390 (48%), Gaps = 51/390 (13%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREV-SGIKAAYEAELG 86
R +E+E ++ LN++ A +ID+VR LE +N L + T +E ++ V ++ +E +
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
+ R+ LD++ ER RL EL +++ ++LK + E +N + A
Sbjct: 220 NLRRQLDNIVGERGRLDSELRNMQDLVEDLKNK-----------------YEDEINKRTA 262
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
A E E L KK + + +V+ + + T+ +E++F
Sbjct: 263 A-----------ENEFVTL--------------KKDVDAAYMNKVELQAKADTLTDEINF 297
Query: 207 QKNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
+ +Y EL + + +T +V +DN + + +S +A E++AQ+E+ ++ + E E
Sbjct: 298 LRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIA----EVKAQYEEIAQRSRAEAE 353
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
Y K + + +A R+ + + +E+ + I L +++ ++KQ A +A + D E
Sbjct: 354 SWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAE 413
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
++ L E + + + + + L EYQEL+++KLALD+EI YRKLLEGEE
Sbjct: 414 QRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEE 473
Query: 385 ERLRLSPSPTSQRSRGRASSHSSQTQGGGS 414
RL+ Q + S S GG S
Sbjct: 474 --CRLNGEGVGQVNISVVQSTVSSGYGGAS 501
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 128 bits (321), Expect = 2e-29
Identities = 91/363 (25%), Positives = 169/363 (46%), Gaps = 49/363 (13%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITE-SEEVVSREVSGIKAAYEAELG 86
R +E+E ++ LN++ A +ID+V+ LE +N L + ++ + ++ +E L
Sbjct: 208 RTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLS 267
Query: 87 DARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEA 146
RK LD++ ++ RLQ EL +++ ++ K TK E ++ A D L
Sbjct: 268 VLRKQLDTLGNDKGRLQSELKTMQDSVEDFK---TKYEEEINKRTAAENDFVVL------ 318
Query: 147 ALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDF 206
KK + L +V+ E ++ ++ +E++F
Sbjct: 319 ---------------------------------KKDVDAAYLNKVELEAKVDSLNDEINF 345
Query: 207 QKNIYSEEL--RETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELE 264
K +Y EL +T + ++ +DN + + +S +A E+RAQ+E+ ++ K E E
Sbjct: 346 LKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIA----EVRAQYEEIAQRSKAEAE 401
Query: 265 KTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLE 324
Y K+ + S +++ + + E+ + I L A++ ++KQ + + D E
Sbjct: 402 ALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAE 461
Query: 325 DSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEE 384
+ E E + + + + + L EYQEL+ +KLALD+EI YRKLLEGEE
Sbjct: 462 QRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEE 521
Query: 385 ERL 387
R+
Sbjct: 522 YRM 524
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 128 bits (321), Expect = 2e-29
Identities = 111/407 (27%), Positives = 191/407 (46%), Gaps = 59/407 (14%)
Query: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIK--AAYEAELGDA 88
EK +Q LNDRLA Y+D+VR+LE NA L ++I + + + S IK + Y + D
Sbjct: 117 EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQ--RQRPSEIKDYSPYFKTIEDL 174
Query: 89 RKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAAL 148
R + + E A+ L++ R + + TK E +L Q
Sbjct: 175 RNKIIAATIENAQPILQIDNARLAADDFR---TKYEHELALRQ----------------- 214
Query: 149 STALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208
T+E +++ LR + L + L R D E +++ +KEEL + +
Sbjct: 215 --------TVEADVNGLR--------------RVLDELTLARTDLEMQIEGLKEELAYLR 252
Query: 209 NIYSEELRETKRRHETRL-VEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTY 267
+ EE+ + + + VE+D + L+ L E+R Q+E E+ +++ E +
Sbjct: 253 KNHEEEMLALRGQTGGDVNVEMDAAPGVD----LSRILNEMRDQYEQMAEKNRRDAETWF 308
Query: 268 SAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSL 327
+K + + NS LV ++ E+ + R + L +L A+ E L + +
Sbjct: 309 LSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRY 368
Query: 328 ARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERL 387
+ + L+ E ++A++R M+QQ EYQ LLD+K L+ EI YR+LLEGE+ L
Sbjct: 369 CMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHL 428
Query: 388 RLSPSPTSQRSRGRA-SSHSSQTQGGGSVTKK-RKLESTESRSSFSQ 432
+SQ++ G++ SS T S +++ R + +S SSFSQ
Sbjct: 429 ------SSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQ 469
>gi|89357932 keratin 5b [Homo sapiens]
Length = 520
Score = 127 bits (318), Expect = 4e-29
Identities = 102/375 (27%), Positives = 174/375 (46%), Gaps = 51/375 (13%)
Query: 25 RITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRI-TESEEVVSREVSGIKAAYEA 83
++ R QE ++++ LN++ A +ID+VR LE +N L + ++ +S G++ +EA
Sbjct: 105 QVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEA 164
Query: 84 ELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNS 143
L RK L+ + ER L EL R++ +E K++
Sbjct: 165 CLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSK------------------------ 200
Query: 144 KEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEE 203
E E H + A LE KK + L +++ E +L+ ++E
Sbjct: 201 --------------YEEEAH----RRATLENDFVVLKKDVDGVFLSKMELEGKLEALREY 242
Query: 204 LDFQKNIYSEELRE--TKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKK 261
L F K++ EEL + T+ + ++ +DN + +F S + E+RA++E+ K
Sbjct: 243 LYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSS----IITEVRARYEEIARSSKA 298
Query: 262 ELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLR 321
E E Y K + SA+ + + + ++ Q I L +Q L+KQ A+ +A +
Sbjct: 299 EAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAIT 358
Query: 322 DLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLE 381
D E ++ + E E + + + + L EYQEL KL+LD+EI YR+LLE
Sbjct: 359 DAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLE 418
Query: 382 GEEERLRLSPSPTSQ 396
GEE R+S TSQ
Sbjct: 419 GEE--CRMSGECTSQ 431
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 125 bits (314), Expect = 1e-28
Identities = 95/388 (24%), Positives = 187/388 (48%), Gaps = 52/388 (13%)
Query: 30 QEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEV-VSREVSGIKAAYEAELGDA 88
+E+E ++ LN++ A +ID+VR LE +N L+ + ++V S ++ +E+ + +
Sbjct: 179 REREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNL 238
Query: 89 RKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAAL 148
R+ +D + +++RL EL +++ ++ + K E ++
Sbjct: 239 RRRVDQLKSDQSRLDSELKNMQDMVEDYR---NKYEDEI--------------------- 274
Query: 149 STALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQK 208
KRT E KK + + +VD + +L +++E+DF
Sbjct: 275 -----NKRT-------------NAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLT 316
Query: 209 NIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKT 266
+Y EL + + + ET ++ +DN + + +S +A E++AQ+ED ++ K E E
Sbjct: 317 ALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIA----EVKAQYEDIAQKSKAEAESL 372
Query: 267 YSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDS 326
Y +K + + +A R+ + V + E+ + I L +++ ++KQ++ + + D E
Sbjct: 373 YQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQR 432
Query: 327 LARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEER 386
++ L + E + + + + + L +YQEL++ KLALD+EI YR LLEGEE R
Sbjct: 433 GENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESR 492
Query: 387 LRLSPSPTSQRSRGRASSHSSQTQGGGS 414
+ +P S S+ + GGGS
Sbjct: 493 MSGECAPNVSVS---VSTSHTTISGGGS 517
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 125 bits (313), Expect = 2e-28
Identities = 95/362 (26%), Positives = 172/362 (47%), Gaps = 48/362 (13%)
Query: 28 RLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGD 87
R +E E ++ LN++ A +ID+VR LE +N L + T +E S + S + +EA++
Sbjct: 88 RQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAG 147
Query: 88 ARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAA 147
R L+++ + RL+ EL +++ ++ K + E +N + AA
Sbjct: 148 LRGQLEALQVDGGRLEAELRSMQDVVEDFKNK-----------------YEDEINHRTAA 190
Query: 148 LSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQ 207
E E L KK + + +V+ E ++ + +E++F
Sbjct: 191 -----------ENEFVVL--------------KKDVDAAYMSKVELEAKVDALNDEINFL 225
Query: 208 KNIYSEELRETKRR-HETRLV-EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEK 265
+ + EL E + + +T +V +DN + + + +A E++AQ+E+ + + E E
Sbjct: 226 RTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIA----EVKAQYEEMAKCSRAEAEA 281
Query: 266 TYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLED 325
Y K + + A ++ + + E+ + I L A++ ++ Q A EA + + E+
Sbjct: 282 WYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEE 341
Query: 326 SLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEE 385
+R E E + + M +QL EYQEL+ +KLALD+EI YRKLLEGEE
Sbjct: 342 RGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEES 401
Query: 386 RL 387
RL
Sbjct: 402 RL 403
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 124 bits (311), Expect = 3e-28
Identities = 101/376 (26%), Positives = 172/376 (45%), Gaps = 48/376 (12%)
Query: 31 EKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARK 90
EK +Q LNDRLA Y+D+VR+LE NA L ++I + + + Y + D R
Sbjct: 115 EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRN 174
Query: 91 TLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALST 150
+ + + A + L++ R L A R K T
Sbjct: 175 KILTATVDNANVLLQIDNAR----------------LAADDFRTK------------YET 206
Query: 151 ALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNI 210
L+ + ++E +++ LR + L + L R D E +++++KEEL + K
Sbjct: 207 ELNLRMSVEADINGLR--------------RVLDELTLARADLEMQIESLKEELAYLKKN 252
Query: 211 YSEELRETKRRHETRL-VEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSA 269
+ EE+ + + + VE+D + L+ L E+R Q+E E+ +K+ E+ +
Sbjct: 253 HEEEMNALRGQVGGDVNVEMDAAPGVD----LSRILNEMRDQYEKMAEKNRKDAEEWFFT 308
Query: 270 KLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLAR 329
K + + NS LV + E+ + R + +L +L A+ E L + +
Sbjct: 309 KTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCM 368
Query: 330 ERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRL 389
+ + ++ E ++A++R M+QQ EY+ LLD+K L+ EI YR+LLEGE+ L
Sbjct: 369 QLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSS 428
Query: 390 SP-SPTSQRSRGRASS 404
S S SQ SR SS
Sbjct: 429 SQFSSGSQSSRDVTSS 444
>gi|125628636 keratin 80 isoform a [Homo sapiens]
Length = 452
Score = 122 bits (306), Expect = 1e-27
Identities = 105/416 (25%), Positives = 195/416 (46%), Gaps = 54/416 (12%)
Query: 30 QEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDAR 89
QEKE+++ LND+ A I +V++LE N L R + + S + + YE G +
Sbjct: 82 QEKEEMKALNDKFASLIGKVQALEQRNQLLETRWSFLQGQDSA-IFDLGHLYEEYQGRLQ 140
Query: 90 KTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALS 149
+ L V++ER +L+ L +V E+ +E + R +
Sbjct: 141 EELRKVSQERGQLEANLLQVLEKVEEFRIRYEDE-------------------------- 174
Query: 150 TALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKN 209
KRT +E + KK L E L R + E +L++++ ++ K
Sbjct: 175 ---ISKRT-------------DMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELMKT 218
Query: 210 IYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSA 269
IY +EL++ + + V + G L+ ++E++AQ++ + +E E +
Sbjct: 219 IYEQELKDLAA--QVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYSRS 276
Query: 270 KLDN-ARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLA 328
+L+ A +SAE S+L ++ E+ +RI L +Q+ ++ E ++ E+
Sbjct: 277 QLEEQAARSAEYGSSLQ-SSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQGE 335
Query: 329 RERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLR 388
++ LA+ E + + + M +QL +YQEL+++KLALD+EI YRKL+EGEE R+
Sbjct: 336 LAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMD 395
Query: 389 LSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK------LESTE-SRSSFSQHARTS 437
+ + R + +S++ + ++K+K ++ TE S FSQ + S
Sbjct: 396 SPSATVVSAVQSRCKTAASRSGLSKAPSRKKKGSKGPVIKITEMSEKYFSQESEVS 451
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,055,865
Number of Sequences: 37866
Number of extensions: 1059600
Number of successful extensions: 13551
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 450
Number of HSP's successfully gapped in prelim test: 985
Number of HSP's that attempted gapping in prelim test: 6264
Number of HSP's gapped (non-prelim): 4379
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.