Search of human proteins with 253970446

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|253970446 odz, odd Oz/ten-m homolog 1 isoform 2 [Homo
sapiens]
         (2731 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|253970446 odz, odd Oz/ten-m homolog 1 isoform 2 [Homo sapiens]    5663   0.0  
gi|253970444 odz, odd Oz/ten-m homolog 1 isoform 1 [Homo sapiens]    5658   0.0  
gi|110347400 odz, odd Oz/ten-m homolog 1 isoform 3 [Homo sapiens]    5636   0.0  
gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]              3680   0.0  
gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]              3420   0.0  
gi|170016091 odz, odd Oz/ten-m homolog 2 [Homo sapiens]              3295   0.0  
gi|153946395 tenascin C precursor [Homo sapiens]                      209   4e-53
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           205   4e-52
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]   148   6e-35
gi|24041035 notch 2 preproprotein [Homo sapiens]                      147   1e-34
gi|4758614 integrin, beta-like 1 (with EGF-like repeat domains) ...   144   9e-34
gi|148833508 notch1 preproprotein [Homo sapiens]                      143   3e-33
gi|4557679 jagged 1 precursor [Homo sapiens]                          138   7e-32
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              137   2e-31
gi|134244285 Notch homolog 3 [Homo sapiens]                           135   6e-31
gi|55770876 notch4 preproprotein [Homo sapiens]                       135   7e-31
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               132   6e-30
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               132   6e-30
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               130   2e-29
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 129   5e-29
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   128   9e-29
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               127   1e-28
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               122   4e-27
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              118   7e-26
gi|116235485 delta-notch-like EGF repeat-containing transmembran...   116   3e-25
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     116   3e-25
gi|93102379 low density lipoprotein-related protein 1B precursor...   114   1e-24
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu...   113   2e-24
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu...   113   2e-24
gi|110735443 delta-like 1 [Homo sapiens]                              113   2e-24

>gi|253970446 odz, odd Oz/ten-m homolog 1 isoform 2 [Homo sapiens]
          Length = 2731

 Score = 5663 bits (14691), Expect = 0.0
 Identities = 2731/2731 (100%), Positives = 2731/2731 (100%)

Query: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60
            MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60

Query: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120
            SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA
Sbjct: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120

Query: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180
            LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV
Sbjct: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180

Query: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240
            QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD
Sbjct: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240

Query: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300
            SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF
Sbjct: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300

Query: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIVHLFGLTWQLQPVEGELYANGV 360
            SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIVHLFGLTWQLQPVEGELYANGV
Sbjct: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIVHLFGLTWQLQPVEGELYANGV 360

Query: 361  SKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQ 420
            SKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQ
Sbjct: 361  SKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQ 420

Query: 421  ITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQH 480
            ITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQH
Sbjct: 421  ITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQH 480

Query: 481  SPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGE 540
            SPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGE
Sbjct: 481  SPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGE 540

Query: 541  CISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTC 600
            CISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTC
Sbjct: 541  CISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTC 600

Query: 601  FGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPV 660
            FGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPV
Sbjct: 601  FGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPV 660

Query: 661  CQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTC 720
            CQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTC
Sbjct: 661  CQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTC 720

Query: 721  EERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG 780
            EERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG
Sbjct: 721  EERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG 780

Query: 781  WHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPL 840
            WHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPL
Sbjct: 781  WHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPL 840

Query: 841  DLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPL 900
            DLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPL
Sbjct: 841  DLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPL 900

Query: 901  VGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVV 960
            VGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVV
Sbjct: 901  VGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVV 960

Query: 961  EKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPS 1020
            EKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPS
Sbjct: 961  EKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPS 1020

Query: 1021 SFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTF 1080
            SFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTF
Sbjct: 1021 SFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTF 1080

Query: 1081 AWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKH 1140
            AWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKH
Sbjct: 1081 AWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKH 1140

Query: 1141 HILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALA 1200
            HILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALA
Sbjct: 1141 HILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALA 1200

Query: 1201 SGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLSD 1260
            SGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLSD
Sbjct: 1201 SGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLSD 1260

Query: 1261 TNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVD 1320
            TNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVD
Sbjct: 1261 TNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVD 1320

Query: 1321 RHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNP 1380
            RHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNP
Sbjct: 1321 RHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNP 1380

Query: 1381 MDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVS 1440
            MDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVS
Sbjct: 1381 MDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVS 1440

Query: 1441 HSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKM 1500
            HSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKM
Sbjct: 1441 HSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKM 1500

Query: 1501 KAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHL 1560
            KAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHL
Sbjct: 1501 KAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHL 1560

Query: 1561 HTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISS 1620
            HTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISS
Sbjct: 1561 HTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISS 1620

Query: 1621 NGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSF 1680
            NGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSF
Sbjct: 1621 NGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSF 1680

Query: 1681 HSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGM 1740
            HSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGM
Sbjct: 1681 HSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGM 1740

Query: 1741 EIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNR 1800
            EIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNR
Sbjct: 1741 EIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNR 1800

Query: 1801 NLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFI 1860
            NLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFI
Sbjct: 1801 NLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFI 1860

Query: 1861 QRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSV 1920
            QRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSV
Sbjct: 1861 QRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSV 1920

Query: 1921 TMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTK 1980
            TMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTK
Sbjct: 1921 TMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTK 1980

Query: 1981 QARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGL 2040
            QARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGL
Sbjct: 1981 QARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGL 2040

Query: 2041 VNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTT 2100
            VNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTT
Sbjct: 2041 VNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTT 2100

Query: 2101 VMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYD 2160
            VMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYD
Sbjct: 2101 VMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYD 2160

Query: 2161 ADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDE 2220
            ADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDE
Sbjct: 2161 ADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDE 2220

Query: 2221 DGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADL 2280
            DGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADL
Sbjct: 2221 DGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADL 2280

Query: 2281 TNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVI 2340
            TNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVI
Sbjct: 2281 TNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVI 2340

Query: 2341 KEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWK 2400
            KEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWK
Sbjct: 2341 KEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWK 2400

Query: 2401 QLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLE 2460
            QLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLE
Sbjct: 2401 QLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLE 2460

Query: 2461 LTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPR 2520
            LTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPR
Sbjct: 2461 LTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPR 2520

Query: 2521 FAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHY 2580
            FAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHY
Sbjct: 2521 FAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHY 2580

Query: 2581 FIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIR 2640
            FIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIR
Sbjct: 2581 FIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIR 2640

Query: 2641 YGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYD 2700
            YGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYD
Sbjct: 2641 YGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYD 2700

Query: 2701 GYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731
            GYFVLSVEQYLELSDSANNIHFMRQSEIGRR
Sbjct: 2701 GYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731


>gi|253970444 odz, odd Oz/ten-m homolog 1 isoform 1 [Homo sapiens]
          Length = 2732

 Score = 5658 bits (14679), Expect = 0.0
 Identities = 2731/2732 (99%), Positives = 2731/2732 (99%), Gaps = 1/2732 (0%)

Query: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60
            MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60

Query: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120
            SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA
Sbjct: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120

Query: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180
            LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV
Sbjct: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180

Query: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240
            QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD
Sbjct: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240

Query: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300
            SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF
Sbjct: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300

Query: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI-VHLFGLTWQLQPVEGELYANG 359
            SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI VHLFGLTWQLQPVEGELYANG
Sbjct: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVEGELYANG 360

Query: 360  VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF 419
            VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF
Sbjct: 361  VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF 420

Query: 420  QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ 479
            QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ
Sbjct: 421  QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ 480

Query: 480  HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG 539
            HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG
Sbjct: 481  HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG 540

Query: 540  ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT 599
            ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT
Sbjct: 541  ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT 600

Query: 600  CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP 659
            CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP
Sbjct: 601  CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP 660

Query: 660  VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT 719
            VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT
Sbjct: 661  VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT 720

Query: 720  CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN 779
            CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN
Sbjct: 721  CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN 780

Query: 780  GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 839
            GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP
Sbjct: 781  GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 840

Query: 840  LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP 899
            LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP
Sbjct: 841  LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP 900

Query: 900  LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV 959
            LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV
Sbjct: 901  LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV 960

Query: 960  VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP 1019
            VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP
Sbjct: 961  VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP 1020

Query: 1020 SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT 1079
            SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT
Sbjct: 1021 SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT 1080

Query: 1080 FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK 1139
            FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK
Sbjct: 1081 FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK 1140

Query: 1140 HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL 1199
            HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL
Sbjct: 1141 HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL 1200

Query: 1200 ASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLS 1259
            ASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLS
Sbjct: 1201 ASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLS 1260

Query: 1260 DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV 1319
            DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV
Sbjct: 1261 DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV 1320

Query: 1320 DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN 1379
            DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN
Sbjct: 1321 DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN 1380

Query: 1380 PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV 1439
            PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV
Sbjct: 1381 PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV 1440

Query: 1440 SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK 1499
            SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK
Sbjct: 1441 SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK 1500

Query: 1500 MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH 1559
            MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH
Sbjct: 1501 MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH 1560

Query: 1560 LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS 1619
            LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS
Sbjct: 1561 LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS 1620

Query: 1620 SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS 1679
            SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS
Sbjct: 1621 SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS 1680

Query: 1680 FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG 1739
            FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG
Sbjct: 1681 FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG 1740

Query: 1740 MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN 1799
            MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN
Sbjct: 1741 MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN 1800

Query: 1800 RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF 1859
            RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF
Sbjct: 1801 RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF 1860

Query: 1860 IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS 1919
            IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS
Sbjct: 1861 IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS 1920

Query: 1920 VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT 1979
            VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT
Sbjct: 1921 VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT 1980

Query: 1980 KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG 2039
            KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG
Sbjct: 1981 KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG 2040

Query: 2040 LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT 2099
            LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT
Sbjct: 2041 LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT 2100

Query: 2100 TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY 2159
            TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY
Sbjct: 2101 TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY 2160

Query: 2160 DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD 2219
            DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD
Sbjct: 2161 DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD 2220

Query: 2220 EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD 2279
            EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD
Sbjct: 2221 EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD 2280

Query: 2280 LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV 2339
            LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV
Sbjct: 2281 LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV 2340

Query: 2340 IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW 2399
            IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW
Sbjct: 2341 IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW 2400

Query: 2400 KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL 2459
            KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL
Sbjct: 2401 KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL 2460

Query: 2460 ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP 2519
            ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP
Sbjct: 2461 ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP 2520

Query: 2520 RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH 2579
            RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH
Sbjct: 2521 RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH 2580

Query: 2580 YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI 2639
            YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI
Sbjct: 2581 YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI 2640

Query: 2640 RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY 2699
            RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY
Sbjct: 2641 RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY 2700

Query: 2700 DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731
            DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR
Sbjct: 2701 DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2732


>gi|110347400 odz, odd Oz/ten-m homolog 1 isoform 3 [Homo sapiens]
          Length = 2725

 Score = 5636 bits (14621), Expect = 0.0
 Identities = 2724/2732 (99%), Positives = 2724/2732 (99%), Gaps = 8/2732 (0%)

Query: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60
            MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ
Sbjct: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60

Query: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120
            SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA
Sbjct: 61   SRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHA 120

Query: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180
            LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV
Sbjct: 121  LRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDV 180

Query: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240
            QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD
Sbjct: 181  QSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQD 240

Query: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300
            SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF
Sbjct: 241  SVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTF 300

Query: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI-VHLFGLTWQLQPVEGELYANG 359
            SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI VHLFGLTWQLQPVEGELYANG
Sbjct: 301  SRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVEGELYANG 360

Query: 360  VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF 419
            VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF
Sbjct: 361  VSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRF 420

Query: 420  QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ 479
            QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ
Sbjct: 421  QITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQ 480

Query: 480  HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG 539
            HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG
Sbjct: 481  HSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNG 540

Query: 540  ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT 599
            ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT
Sbjct: 541  ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPT 600

Query: 600  CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP 659
            CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP
Sbjct: 601  CFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLP 660

Query: 660  VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT 719
            VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT
Sbjct: 661  VCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPT 720

Query: 720  CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN 779
            CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN
Sbjct: 721  CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQN 780

Query: 780  GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 839
            GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP
Sbjct: 781  GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 840

Query: 840  LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP 899
            LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP
Sbjct: 841  LDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTP 900

Query: 900  LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV 959
            LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV
Sbjct: 901  LVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIV 960

Query: 960  VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP 1019
            VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP
Sbjct: 961  VEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIP 1020

Query: 1020 SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT 1079
            SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT
Sbjct: 1021 SSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYT 1080

Query: 1080 FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK 1139
            FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK
Sbjct: 1081 FAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNK 1140

Query: 1140 HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL 1199
            HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL
Sbjct: 1141 HHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVAL 1200

Query: 1200 ASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLS 1259
            ASGPDGSVYVGDFNFVRRIFPSGNSVSILEL       STSPAHKYYLAMDPVSESLYLS
Sbjct: 1201 ASGPDGSVYVGDFNFVRRIFPSGNSVSILEL-------STSPAHKYYLAMDPVSESLYLS 1253

Query: 1260 DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV 1319
            DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV
Sbjct: 1254 DTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITV 1313

Query: 1320 DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN 1379
            DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN
Sbjct: 1314 DRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVN 1373

Query: 1380 PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV 1439
            PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV
Sbjct: 1374 PMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISV 1433

Query: 1440 SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK 1499
            SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK
Sbjct: 1434 SHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAK 1493

Query: 1500 MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH 1559
            MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH
Sbjct: 1494 MKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTH 1553

Query: 1560 LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS 1619
            LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS
Sbjct: 1554 LHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTIS 1613

Query: 1620 SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS 1679
            SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS
Sbjct: 1614 SNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSS 1673

Query: 1680 FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG 1739
            FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG
Sbjct: 1674 FHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASG 1733

Query: 1740 MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN 1799
            MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN
Sbjct: 1734 MEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHN 1793

Query: 1800 RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF 1859
            RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF
Sbjct: 1794 RNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTF 1853

Query: 1860 IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS 1919
            IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS
Sbjct: 1854 IQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLS 1913

Query: 1920 VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT 1979
            VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT
Sbjct: 1914 VTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYT 1973

Query: 1980 KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG 2039
            KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG
Sbjct: 1974 KQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEG 2033

Query: 2040 LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT 2099
            LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT
Sbjct: 2034 LVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITT 2093

Query: 2100 TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY 2159
            TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY
Sbjct: 2094 TVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEY 2153

Query: 2160 DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD 2219
            DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD
Sbjct: 2154 DADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMD 2213

Query: 2220 EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD 2279
            EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD
Sbjct: 2214 EDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYAD 2273

Query: 2280 LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV 2339
            LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV
Sbjct: 2274 LTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQV 2333

Query: 2340 IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW 2399
            IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW
Sbjct: 2334 IKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIW 2393

Query: 2400 KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL 2459
            KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL
Sbjct: 2394 KQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENL 2453

Query: 2460 ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP 2519
            ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP
Sbjct: 2454 ELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQP 2513

Query: 2520 RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH 2579
            RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH
Sbjct: 2514 RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTH 2573

Query: 2580 YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI 2639
            YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI
Sbjct: 2574 YFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNI 2633

Query: 2640 RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY 2699
            RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY
Sbjct: 2634 RYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGY 2693

Query: 2700 DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731
            DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR
Sbjct: 2694 DGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2725


>gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]
          Length = 2769

 Score = 3680 bits (9544), Expect = 0.0
 Identities = 1753/2801 (62%), Positives = 2155/2801 (76%), Gaps = 102/2801 (3%)

Query: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQ 60
            M+  + KPY+ L + + + +  YTSSS +SE+G+ P++SY+S ETL  Y+Q+ R+ Y S+
Sbjct: 1    MDVKERKPYRSLTR-RRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSR 59

Query: 61   SRKRKEVEKSTQEMEFCETSHTLC--------------SGYQTDMHSVSRHGYQLEMGSD 106
                K++     E EFC T                   + Y+TD+  +   GY +  GSD
Sbjct: 60   V---KDIVPQEAE-EFCRTGANFTLRELGLEEVTPPHGTLYRTDI-GLPHCGYSMGAGSD 114

Query: 107  VDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHER-KSDGENGFKFSP 165
             D E +   SP+H +R+W R  +S  SSCLSSRANS L+LTDT+HE  ++D   G +   
Sbjct: 115  ADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQ--- 171

Query: 166  VCCDMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRS 225
                                N    R   PPPP  HA T  +    + +SL R + T RS
Sbjct: 172  --------------------NHARLRT--PPPPLSHAHTPNQHHAASINSLNRGNFTPRS 209

Query: 226  QPSPA-------APAPPTSTQDSVHLHNSWVLNSNIPLETR------------------- 259
             PSPA          P    Q+  H   +W+LNSNIPLETR                   
Sbjct: 210  NPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMD 269

Query: 260  --------------HFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTFSRPAF 305
                          HFLFK G G+S +F   S  YPLTS+TVYSPPPRPLPRSTF+RPAF
Sbjct: 270  ILGASRHDGAYSDGHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAF 328

Query: 306  TFNKPYRCCNWKCTALSATAITVTLALLLAY-VIVHLFGLTWQLQPVEGELYANGVSKGN 364
               KP + CNWKC ALSA  I+ TL +LLAY V +HLFGL W LQP+EG++Y       +
Sbjct: 329  NLKKPSKYCNWKCAALSAIVISATLVILLAYFVAMHLFGLNWHLQPMEGQMYEITEDTAS 388

Query: 365  RGTESMDTTYSPIGGKVSDKSEKK-----------VFQKGRAIDTGEVDIGAQVMQTIPP 413
                  D +  P GG   +  ++K            F +   ID+GE+D+G +  Q IPP
Sbjct: 389  SWPVPTDVSLYPSGGTGLETPDRKGKGTTEGKPSSFFPEDSFIDSGEIDVGRRASQKIPP 448

Query: 414  GLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSK 473
            G FWR Q+ I HP++LKFN+SL K +L+GIYGR+ +PP+HTQFDFV+L+DG++L+ Q+++
Sbjct: 449  GTFWRSQVFIDHPVHLKFNVSLGKAALVGIYGRKGLPPSHTQFDFVELLDGRRLLTQEAR 508

Query: 474  GSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCST 533
              + T    R  +  S  ETGFI+Y+D G W+LAFYNDGK+ E V  LTTAIE +D+C +
Sbjct: 509  SLEGTPRQSRGTVPPSSHETGFIQYLDSGIWHLAFYNDGKESEVVSFLTTAIESVDNCPS 568

Query: 534  NCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEE 593
            NC GNG+CISG CHCF GFLGPDC R SCPVLC GNG+Y KG C+C  GWKG ECDVP  
Sbjct: 569  NCYGNGDCISGTCHCFLGFLGPDCGRASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTN 628

Query: 594  QCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVN 653
            QCID  C  HGTCI G CIC PGYKGE CEE DC+DP CS  G+CV+GECHCS GWGG N
Sbjct: 629  QCIDVACSNHGTCITGTCICNPGYKGESCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTN 688

Query: 654  CETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEE 713
            CETP   C +QCSGHGTFL D G+CSCDP WTG DCS E+C  +CG HGVC  G C+CE+
Sbjct: 689  CETPRATCLDQCSGHGTFLPDTGLCSCDPSWTGHDCSIEICAADCGGHGVCVGGTCRCED 748

Query: 714  GWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLD-AVRDGCPGLCFGNG 772
            GW+G  C++R+CH  C EHG C+DGKCECSPGW G+HCTIAHYLD  V++GCPGLC GNG
Sbjct: 749  GWMGAACDQRACHPRCAEHGTCRDGKCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNG 808

Query: 773  RCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPL 832
            RCTLD NGWHCVCQ+GW G GC+  ME  CGD+ DNDGDGL DC+DPDCC Q  C+I+PL
Sbjct: 809  RCTLDLNGWHCVCQLGWRGAGCDTSMETACGDSKDNDGDGLVDCMDPDCCLQPLCHINPL 868

Query: 833  CQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQV 892
            C GSP+PLD+IQ++Q   SQ     FYDRIKFL+G+DSTH+IP E  FD   ACVIRGQV
Sbjct: 869  CLGSPNPLDIIQETQVPVSQQNLHSFYDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQV 928

Query: 893  VAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWL 952
            +  DGTPLVGVN+SF+++  +G+TISRQDGSFDLV  GGIS+IL F+R+PF+ ++ TLWL
Sbjct: 929  MTSDGTPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEHTLWL 988

Query: 953  PWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVV 1012
            PW++F V+E + M+   ++ PSCD+SNF  PNP+V PSPLTSF  SC E+G IVPE+Q +
Sbjct: 989  PWDRFFVMETIIMRHEENEIPSCDLSNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQAL 1048

Query: 1013 QEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPA 1072
            QEEI I    +RLSYLSSRTPGYK++LRI LTH TIP  ++KVHL VAVEGRL +KWF A
Sbjct: 1049 QEEISISGCKMRLSYLSSRTPGYKSVLRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAA 1108

Query: 1073 AINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNL 1132
            A +L Y F W+KTD+Y QKV+GL+EA VSVGYEYE+CPD ILWE+RT VLQG+E+DAS L
Sbjct: 1109 APDLSYYFIWDKTDVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKL 1168

Query: 1133 GGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNK 1192
            GGWSL+KHH LN QSGI+HKGNGEN F+SQQPPVI +IMGNG +RS++C +CNG A  NK
Sbjct: 1169 GGWSLDKHHALNIQSGILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNK 1228

Query: 1193 LFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPV 1252
            L APVAL  G DGS+YVGDFN++RRIFPSGN  +ILELRN+D RHS SPAHKYYLA DP+
Sbjct: 1229 LLAPVALTCGSDGSLYVGDFNYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYYLATDPM 1288

Query: 1253 SESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLN 1312
            S +++LSD+N+R+V+K+KS V  KDL KN EVVAGTGDQCLPFD + CGDGG+A+EA+L 
Sbjct: 1289 SGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLT 1348

Query: 1313 SPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEW 1372
            +PRGITVD+ G IYFVDGTMIR+ID+N +I+T++GSN LTS +PLSCDS MDI+QV LEW
Sbjct: 1349 NPRGITVDKFGLIYFVDGTMIRRIDQNGIISTLLGSNDLTSARPLSCDSVMDISQVHLEW 1408

Query: 1373 PTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLE 1432
            PTDLA+NPMDNSLYVLDNN+VLQISEN +VRI+AGRP+HCQVPGIDHFL+SKVAIH+TLE
Sbjct: 1409 PTDLAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLE 1468

Query: 1433 SARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDG 1492
            SA A++VSH+G+L+IAETDE+K+NRI+QVTT+GEI ++AGAP+ CDCK D NCDCFSGD 
Sbjct: 1469 SATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGDD 1528

Query: 1493 GYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQ 1552
            GYAKDAK+  PSSLAV  DG LYVADLGN+RIR I +N+  LN  N+YE++SP DQELY 
Sbjct: 1529 GYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYL 1588

Query: 1553 FTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQ 1612
            F   G HL+T +L T DY+YNFTY  +GD+  IT +NGN V++RRD+ GMPLWLVVP GQ
Sbjct: 1589 FDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQ 1648

Query: 1613 VYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATF 1672
            VYW+T+ +N  LK V+ QG+ LA+MTY GN+GLLATKSNENGWTT YEYD  G LTN TF
Sbjct: 1649 VYWVTMGTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTF 1708

Query: 1673 PTGEVSSFHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSL 1732
            PTG+VSSF SD +    V+++TS++++V ++TNL+A+   Y L Q+  +++Y +  DGSL
Sbjct: 1709 PTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQDQVRNSYYIGADGSL 1768

Query: 1733 RVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFE 1792
            R+  A+GME+ L +EPH+LAG VNPT+GK N++LP ++  NL+EWRQRKEQ +G V+ F 
Sbjct: 1769 RLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFG 1828

Query: 1793 RRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYS 1852
            RRLR HNRNLLS+DFD +TRT KIYDDHRKFTLRILYDQ GRP LWSP SR N VN+TYS
Sbjct: 1829 RRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYS 1888

Query: 1853 PSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYD 1912
            P G +  IQRG  +E+MEYDQ+G+I SR +ADGK WSYTYLEKS++LLLHSQR+YIFE+D
Sbjct: 1889 PGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFD 1948

Query: 1913 QPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGR 1972
            + D L SVTMP++ R +L+T+ SVGYYRNIY PP+ + S IQD++ DG LL T +LGTGR
Sbjct: 1949 KNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGR 2008

Query: 1973 RVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQI 2032
            RV+YKY K ++L+E LYDTT+V+ TY+E++G++KTI+L ++GF CTIRYRQ GPLI RQI
Sbjct: 2009 RVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQI 2068

Query: 2033 FRFSEEGLVNARFDYSY-NNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINY 2091
            FRF+EEG+VNARFDY+Y N+FRVTSMQAVINETPLPIDLYRY DVSG+TEQFGKF VI Y
Sbjct: 2069 FRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYY 2128

Query: 2092 DLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDAN 2151
            D+NQ+ITT VM HTK F A G++ EVQYEI +++ YWMT+QYDN+GR+V  +++VG  AN
Sbjct: 2129 DINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYAN 2188

Query: 2152 ITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRL 2211
             TRY YEYDADGQLQTVS+NDK  WRYSYDLNGN++LLS G SARLTPLRYD+RDRITRL
Sbjct: 2189 TTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRL 2248

Query: 2212 GEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQ 2271
            G++QYKMDEDGFLRQRG DIFEYNS GLL KAYN+A  W+V+Y YDGLGRRV+SKSS   
Sbjct: 2249 GDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSH 2308

Query: 2272 HLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLA 2331
            HLQFFYADLTNP +VTHLYNH+SSEITSLYYDLQGHL AMELSSG+E+Y+ACDN GTPLA
Sbjct: 2309 HLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLA 2368

Query: 2332 VFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRW 2391
            VFS  G +IK+ILYT YG+IY DT P+FQ+IIG+HGGLYD LTKLVH+G+RDYDV+AGRW
Sbjct: 2369 VFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRW 2428

Query: 2392 TTPNHHIWKQLNLL-PKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPG 2450
            T+P+H +WK L+     PFNLY F+NN P+   QD+  + TD+ SWL  FGFQLHNV+PG
Sbjct: 2429 TSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPG 2488

Query: 2451 FPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDG 2510
            +PKP+++ +E +YEL+  Q KTQEWD  K+ILG+QCE+QKQL+ F++L++          
Sbjct: 2489 YPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTIT 2548

Query: 2511 RCLEGGKQPRFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLH 2570
             C +  K  +FA+  SVFGKG+KFA+KDG VT DII VANED RR+AAILN+AHYLENLH
Sbjct: 2549 SCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLH 2608

Query: 2571 FTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQL 2630
            FTI+G DTHYF+K G  E DL ++G +GGRR LENGVNVTVSQ+ +VLNGRTRR+ DIQL
Sbjct: 2609 FTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQL 2668

Query: 2631 QHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQL 2690
            Q+GALC N RYGTT++EEK  VLE+ARQRAV QAW +EQ+RL+EGEEG+RAWTEGEKQQ+
Sbjct: 2669 QYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQV 2728

Query: 2691 LSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731
            LSTGRVQGYDG+FV+SVEQY ELSDSANNIHFMRQSE+GRR
Sbjct: 2729 LSTGRVQGYDGFFVISVEQYPELSDSANNIHFMRQSEMGRR 2769


>gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
          Length = 2699

 Score = 3420 bits (8868), Expect = 0.0
 Identities = 1620/2754 (58%), Positives = 2086/2754 (75%), Gaps = 78/2754 (2%)

Query: 1    MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQ-SYNSRETLHEYNQEL-RMNYN 58
            M+  + +PY  L K + E +  YT+SS ++E+ R P Q SY+S ETL  ++ +  R+ Y 
Sbjct: 1    MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYG 60

Query: 59   SQSRK--RKEVEKSTQE--------MEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVD 108
            ++ +    +E ++ T++        +  CE +      +  +M  +   GY +  GSD D
Sbjct: 61   NRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEM-GLPHRGYSISAGSDAD 119

Query: 109  TETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCC 168
            TE E   SP+HA+R+W RG+KS  SSCLSSR+NSAL+LTDT+HE KSD EN         
Sbjct: 120  TENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN--------- 170

Query: 169  DMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPS 228
                      +  +S   Q T +PLPP      A     +  P+  SL R S+T R   S
Sbjct: 171  ----------EQPASNQGQSTLQPLPPSHKQHSA-----QHHPSITSLNRNSLTNRRNQS 215

Query: 229  PAAPAPPTS----TQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTS 284
            PA PA   +    T +SV L +SWVL SN+PLE+RHFLFK G+G++ +FS A+  Y + S
Sbjct: 216  PAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMAS 275

Query: 285  NTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVI-VHLFG 343
             +VYSPP RPLPR+T SR AF F K  + C+WKCTAL A  ++V LA+LL+Y I +HLFG
Sbjct: 276  GSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFG 335

Query: 344  LTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIG--GKVSDKSEKKVFQKGRAIDTGEV 401
            L WQLQ  E + + NG  K N  T   +T   P G  GK+   +     Q+   ID+GE+
Sbjct: 336  LNWQLQQTENDTFENG--KVNSDTMPTNTVSLPSGDNGKLGGFT-----QENNTIDSGEL 388

Query: 402  DIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKL 461
            DIG + +Q IPPG+FWR Q+ I  P +LKFNISL KD+L+G+YGR+ +PP+HTQ+DFV+L
Sbjct: 389  DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVEL 448

Query: 462  MDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVL 521
            +DG +L+ ++ +   +T+ + R     SL E GFI+Y+D G W+LAFYNDGK  EQV   
Sbjct: 449  LDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFN 508

Query: 522  TTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRH 581
            T  IE + +C  NC+GNGEC+SG CHCFPGFLGPDC+R +CPVLC GNG+Y KG C+C  
Sbjct: 509  TIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFS 568

Query: 582  GWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKG 641
            GWKG ECDVP  QCIDP C G G CIMG C C  GYKGE CEE DC+DP CSNHG+C+ G
Sbjct: 569  GWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHG 628

Query: 642  ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSH 701
            ECHCS GWGG NCE    +C +QCSGHGT+L ++G C+CDP WTG DCS E+C+++CGSH
Sbjct: 629  ECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH 688

Query: 702  GVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVR 761
            GVC  G C+CEEGW GP C +R+CH  C EHG CKDGKCECS GW G+HCTI        
Sbjct: 689  GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTI-------- 740

Query: 762  DGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 821
            +GCPGLC  NGRCTLDQNGWHCVCQ GW G GC+V ME LC D+ DN+GDGL DC+DPDC
Sbjct: 741  EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDC 800

Query: 822  CQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFD 881
            C QS+C   P C+G PDP D+I QS    SQ  ++ FYDRI FLIG DSTHVIP E  F+
Sbjct: 801  CLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFN 860

Query: 882  SRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRS 941
               A VIRGQV+  DGTPL+GVNVSF H+ +YG+TI+RQDG FDLVA GG S+ L+F+RS
Sbjct: 861  KSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERS 920

Query: 942  PFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPE 1001
            PFL +  T+W+PWN F V++ + M++  +D PSCD+S F+ PNPI++ SPL++F  S PE
Sbjct: 921  PFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPE 980

Query: 1002 RGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAV 1061
               I+PE QV+ EE  IP + ++LSYLSSR  GYK++L+I +T S IP  ++KVHL VAV
Sbjct: 981  DSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAV 1040

Query: 1062 EGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVV 1121
             GRL QKWFPA+ NL YTF W+KTD Y QKV+GL+EA+VSVGYEYE+C D  LWE+RT +
Sbjct: 1041 VGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAI 1100

Query: 1122 LQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVAC 1181
            LQG+E+DASN+GGW+L+KHH+L+ Q+GI++KGNGEN FISQQPPV+S+IMGNG +RS++C
Sbjct: 1101 LQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISC 1160

Query: 1182 TNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSP 1241
             +CNG A  NKL APVALA G DGS+YVGDFN+VRRIFPSGN  S+LEL       S++P
Sbjct: 1161 PSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLEL-------SSNP 1213

Query: 1242 AHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCG 1301
            AH+YYLA DPV+  LY+SDTNTR++Y+ KSL   KDL+KN EVVAGTG+QCLPFD++ CG
Sbjct: 1214 AHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCG 1273

Query: 1302 DGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDS 1361
            DGG+A EA+L SP+G+ VD++G IYFVDGTMIRK+D+N +I+T++GSN LTS +PL+CD+
Sbjct: 1274 DGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDT 1333

Query: 1362 GMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFL 1421
             M I+QVRLEWPTDLA+NPMDNS+YVLDNN+VLQI+ENR+VRI AGRP+HCQVPG++ + 
Sbjct: 1334 SMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVE-YP 1392

Query: 1422 VSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKI 1481
            V K A+ +TLESA AI+VS+SG+L+I ETDE+K+NRI+QVTT+GEI ++AG P++CDCK 
Sbjct: 1393 VGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKN 1452

Query: 1482 DPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYE 1541
            D NCDC+    GYAKDAK+ APSSLA SPDGTLY+ADLGN+RIR +S+N+  LN MN YE
Sbjct: 1453 DANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYE 1512

Query: 1542 IASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGG 1601
            +ASP DQELY F +NGTH +T++L+T DY+YNF+Y+++ D+ A+T SNGN++ IRRD   
Sbjct: 1513 VASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNR 1572

Query: 1602 MPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEY 1661
            MP+ +V P  QV WLTI +NG LK ++AQG  L L TY GN+GLLATKS+E GWTT ++Y
Sbjct: 1573 MPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDY 1632

Query: 1662 DPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNR-ENVLMSTNLTATSTIYILKQENT 1720
            D EG LTN TFPTG V++ H D++K   V++++S+R E+V +++NL++  + Y + Q+  
Sbjct: 1633 DSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQL 1692

Query: 1721 QSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQR 1780
            +++Y++  DGSLR+ +ASG++    +EPH+LAG  NPT+ K N++LPGE+  NL+EWR R
Sbjct: 1693 RNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFR 1752

Query: 1781 KEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSP 1840
            KEQ +G V+ F R+LR + RNLLS+DFD  T+T KIYDDHRKF LRI YD +G P LW P
Sbjct: 1753 KEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP 1812

Query: 1841 VSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLL 1900
             S+   VN+TYS +G +  IQRGT +EK++YD  G+I+SR +ADGK WSYTYLEKS++LL
Sbjct: 1813 SSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLL 1872

Query: 1901 LHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDG 1960
            LHSQR+YIFEYD  D L ++TMPS+ RH++QT+ S+GYYRNIY PP+S+ S I DY+ +G
Sbjct: 1873 LHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEG 1932

Query: 1961 RLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIR 2020
             LLQT  LGT RRVL+KY +Q RLSE+LYD+T+V+ TY+E++GV+KT++L  DGFICTIR
Sbjct: 1933 LLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIR 1992

Query: 2021 YRQTGPLIGRQIFRFSEEGLVNARFDYSY-NNFRVTSMQAVINETPLPIDLYRYVDVSGR 2079
            YRQ GPLI RQIFRFSE+G+VNARFDYSY N+FRVTSMQ VINETPLPIDLY++ D+SG+
Sbjct: 1993 YRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGK 2052

Query: 2080 TEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRM 2139
             EQFGKF VI YD+NQ+I+T VM +TK F A+G++ E+QYEI +++ YW+TIQYDN+GR+
Sbjct: 2053 VEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRV 2112

Query: 2140 VICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTP 2199
               +I++G  AN T+Y YEYD DGQLQTV +N+K  WRY+YDLNGN++LL+   SARLTP
Sbjct: 2113 TKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP 2172

Query: 2200 LRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGL 2259
            LRYDLRDRITRLG++QY++DEDGFLRQRG +IFEY+S GLL + Y+K SGWTV Y YDGL
Sbjct: 2173 LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGL 2232

Query: 2260 GRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEY 2319
            GRRV+SK+SLGQHLQFFYADLT P R+TH+YNH+SSEITSLYYDLQGHL AME+SSG+E+
Sbjct: 2233 GRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEF 2292

Query: 2320 YVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHL 2379
            Y+A DNTGTPLAVFSS G ++K+I YT YG+IY D+  DFQ++IGFHGGLYD LTKL+H 
Sbjct: 2293 YIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHF 2352

Query: 2380 GQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLEL 2439
            G+RDYD++AGRWTTP+  IWK++   P PFNLY F NN P  KI DV  Y TD+ SWL  
Sbjct: 2353 GERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVT 2412

Query: 2440 FGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLD 2499
            FGF LHN +PGFP P+ +  E +YEL+    K+Q+WD    I G+Q ++ +Q + F+SL 
Sbjct: 2413 FGFHLHNAIPGFPVPKFDLTEPSYELV----KSQQWDDIPPIFGVQQQVARQAKAFLSLG 2468

Query: 2500 QLPMTPRYNDGRCLEGGKQP--RFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLA 2557
            ++         R   GG Q    FA V S+ GKG+  A+  G V  +++ +ANED  ++A
Sbjct: 2469 KM---AEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVA 2525

Query: 2558 AILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSV 2617
            A+LNNA YLENLHFTIEG+DTHYFIK  + E DL  +  T GR+ LENG+NVTVSQ T+V
Sbjct: 2526 AVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTV 2585

Query: 2618 LNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEE 2677
            +NGRTRRFAD+++Q GAL  ++RYG T++EEK  +LE ARQRA+A+AW +EQ+R+++GEE
Sbjct: 2586 VNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEE 2645

Query: 2678 GIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR 2731
            G R WTEGEK+QLLS G+VQGYDGY+VLSVEQY EL+DSANNI F+RQSEIGRR
Sbjct: 2646 GARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR 2699


>gi|170016091 odz, odd Oz/ten-m homolog 2 [Homo sapiens]
          Length = 2765

 Score = 3295 bits (8544), Expect = 0.0
 Identities = 1589/2778 (57%), Positives = 2055/2778 (73%), Gaps = 103/2778 (3%)

Query: 23   YTSSSDESEDGRKPRQ-SYNSRETLHEYNQELRMNYN----------SQSRKRKEVEKST 71
            YTSSS +SED R P Q SY+S ETL  Y+ + RM+Y           S    R+    + 
Sbjct: 22   YTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQGTNFTL 81

Query: 72   QEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSE 131
             E+  CE S    SGY +DM  +   GY L  GSD D++TEG  SP+HA+R+W RG+KS 
Sbjct: 82   AELGICEPSPHR-SGYCSDM-GILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSR 139

Query: 132  HSSCLSSRANSALSLTDTDHERKSDGENGFKF--------------------SPVCCDM- 170
             SS LSSR NSAL+LTD+D+E KSD ENG                        PV C M 
Sbjct: 140  RSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMP 199

Query: 171  --------------------------EAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACT 204
                                       A +G  Q   S P N  +   L PP PPPH  T
Sbjct: 200  LLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHT 259

Query: 205  CARKPPPAADSLQRRSMTT-RSQPSPAAPAPP--TSTQDSVHLHNSWVLNSNIPLETRHF 261
             +     +A+SL R S+T  RSQ    APAP    +T +SV L +SWVLNSN+PLETRHF
Sbjct: 260  LSHH-HSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHF 318

Query: 262  LFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTAL 321
            LFK  SGS+ +FS++S  YPLTS TVY+PPPR LPR+TFSR AF   KP + C+WKC AL
Sbjct: 319  LFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAAL 378

Query: 322  SATAITVTLALLLAYVI-VHLFGLTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIGGK 380
            SA A  + LA+LLAY I +HL GL WQLQP +G  + NG+  G  G +  D    P GGK
Sbjct: 379  SAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGLPGND--DVATMPSGGK 436

Query: 381  VSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSL 440
            V          K  +ID+GE ++G +V Q +PPG+FWR QI I  P +LKFNISL KD+L
Sbjct: 437  VPWS------LKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDAL 490

Query: 441  LGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQHSPRNLILTSLQ-ETGFIEYM 499
             G+Y RR +PP+H Q+DF++ +DGK+      K S       R  I T +Q E  F++Y+
Sbjct: 491  FGVYIRRGLPPSHAQYDFMERLDGKE------KWSVVESPRERRSIQTLVQNEAVFVQYL 544

Query: 500  DQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCAR 559
            D G W+LAFYNDGK  E V   T  ++ + DC  NC+GNGEC+SG CHCFPGFLG DCA+
Sbjct: 545  DVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAK 604

Query: 560  DSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKG 619
             +CPVLC GNG+Y KG C C  GWKG ECDVP  QCIDP+C GHG+CI G C+C  GYKG
Sbjct: 605  AACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKG 664

Query: 620  EICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCS 679
            E CEE DCLDP CS+HG+CV GEC CS GWGG+NCE     C +QCSGHGT+L D G+CS
Sbjct: 665  EHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCS 724

Query: 680  CDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGK 739
            CDP W G DCS E+C+++CG+HGVC  G C+CEEGW G  C++R CH  C EHG CKDGK
Sbjct: 725  CDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGK 784

Query: 740  CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVME 799
            CEC  GW G+HCTI        DGCP LC GNGRCTL QN W CVCQ GW G GCNV ME
Sbjct: 785  CECREGWNGEHCTI--------DGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAME 836

Query: 800  MLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFY 859
              C DN DN+GDGL DC+DPDCC QS C  S LC+GS DPLD+IQQ QT +    S  FY
Sbjct: 837  TSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKS--FY 894

Query: 860  DRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISR 919
            DRIK L GKDSTH+IP E  F+S    +IRGQVV  DGTPLVGVNVSF+ +  YG+TI+R
Sbjct: 895  DRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITR 954

Query: 920  QDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISN 979
            QDG+FDL+A GG S+ L F+R+PF+ ++RT+WLPWN F  ++ + M+   +  PSCD+S 
Sbjct: 955  QDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSG 1014

Query: 980  FISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLL 1039
            F+ P+PI++ SPL++F  + P +  IVPE QV+ EEI +P S V+L YLSSRT GYK+LL
Sbjct: 1015 FVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLL 1074

Query: 1040 RILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEAL 1099
            +I +T ST+P+ +I+VHL VAVEG L QK F A+ NL YTF W+KTD YGQ+V+GL++A+
Sbjct: 1075 KITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAV 1134

Query: 1100 VSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMF 1159
            VSVG+EYETCP  ILWE+RT +LQGFE+D SNLGGWSL+KHHILN +SGI+HKG GEN F
Sbjct: 1135 VSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQF 1194

Query: 1160 ISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIF 1219
            ++QQP +I++IMGNG +RS++C +CNG A  NKL APVALA G DGS+YVGDFN++RRIF
Sbjct: 1195 LTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIF 1254

Query: 1220 PSGNSVSILELRNRDTRHSTSPAHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLS 1279
            PS N  SILELRN++ +HS +PAHKYYLA+DPVS SLY+SDTN+R++Y++KSL  TKDL+
Sbjct: 1255 PSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLA 1314

Query: 1280 KNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDEN 1339
             N EVVAGTG+QCLPFD++ CGDGG+A +A+L SPRGI VD++G +YFVD TMIRK+D+N
Sbjct: 1315 GNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQN 1374

Query: 1340 AVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISEN 1399
             +I+T++GSN LT+ +PLSCDS MD+ QVRLEWPTDLAVNPMDNSLYVL+NN++L+I+EN
Sbjct: 1375 GIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITEN 1434

Query: 1400 RRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQ 1459
             +V IIAGRP+HCQVPGID+ L SK+AIHS LESA AI++SH+G+L+I ETDE+K+NR++
Sbjct: 1435 HQVSIIAGRPMHCQVPGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEKKINRLR 1493

Query: 1460 QVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADL 1519
            QVTTNGEI ++AGA +DCDCK D NC+C+SGD  YA DA + +PSSLAV+PDGT+Y+ADL
Sbjct: 1494 QVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADL 1553

Query: 1520 GNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSE 1579
            GN+RIR +S+N+  LN  N YE ASP +QELY F  +G H +T++L+T +Y+YNFTY+++
Sbjct: 1554 GNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTD 1613

Query: 1580 GDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTY 1639
             D+  +  +NGNS+ IRRD+ GMP  L++P  Q+  LT+ +NG LK VS Q   L LMTY
Sbjct: 1614 NDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTY 1673

Query: 1640 PGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNR-E 1698
             GNTGLLATKS+E GWTT Y+YD EG LTN T PTG V+S H ++EK   ++++ SNR +
Sbjct: 1674 DGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDD 1733

Query: 1699 NVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPT 1758
            +V + TNL++    Y + Q+  +++Y++  +G+LRV +A+GM I   SEPH+LAG + PT
Sbjct: 1734 DVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPT 1793

Query: 1759 LGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYD 1818
            +G+CNISLP E+  N IEWR RKEQ KG V+ F R+LR H RNLLSID+D   RT KIYD
Sbjct: 1794 IGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYD 1853

Query: 1819 DHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKII 1878
            DHRKFTLRI+YDQ GRP LW P S    VN++Y  +G +  +QRG  +E+ + D+ G+I+
Sbjct: 1854 DHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIV 1913

Query: 1879 SRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGY 1938
            SR +ADGK+WSY+YL+KS++LLL SQR+YIFEYD  D LL+VTMPS+ RHS+ T  S+GY
Sbjct: 1914 SRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGY 1973

Query: 1939 YRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTY 1998
             RNIY PP+S+ S I DYS DGR+L+T  LGTGR+V YKY K ++LSE++YD+T VT  Y
Sbjct: 1974 IRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGY 2033

Query: 1999 EESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGLVNARFDYSY--NNFRVTS 2056
            +E++GV+K ++L   GF CTIRYR+ GPL+ +QI+RFSEEG+VNARFDY+Y  N+FR+ S
Sbjct: 2034 DETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIAS 2093

Query: 2057 MQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIE 2116
            ++ VI+ETPLP+DLYRY ++SG+ E FGKF VI YD+NQ+ITT VM  +K F  +G++ E
Sbjct: 2094 IKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKE 2153

Query: 2117 VQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQW 2176
            VQYE+ +++ YWMT+QYD++GR++  ++++G  AN T+Y Y+YD DGQLQ+V+VND+  W
Sbjct: 2154 VQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTW 2213

Query: 2177 RYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNS 2236
            RYSYDLNGN++LL+ G S RL PLRYDLRDRITRLG++QYK+D+DG+L QRG+DIFEYNS
Sbjct: 2214 RYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNS 2273

Query: 2237 NGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSE 2296
             GLL +AYNKASGW+VQY YDG+GRR + K++LG HLQ+FY+DL NP R+TH+YNH++SE
Sbjct: 2274 KGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSE 2333

Query: 2297 ITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTY 2356
            ITSLYYDLQGHL AME SSGEEYYVA DNTGTPLAVFS  G +IK++ YT YG+IY+D+ 
Sbjct: 2334 ITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSN 2393

Query: 2357 PDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFEN 2416
            PDFQ++IGFHGGLYD LTKLVH  QRDYDV+AGRWT+P++ +WK +   P PFNLY F++
Sbjct: 2394 PDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKS 2453

Query: 2417 NYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWD 2476
            N P+    D+  Y TD++SWL +FGFQL N++PGFP+ ++  +   YEL    +++Q  +
Sbjct: 2454 NNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYEL----SESQASE 2509

Query: 2477 PGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPRFAAVPSVFGKGIKFAI 2536
             G+ I G+Q   ++  + F++L+   +T + +     + G    FA    + GKGI FAI
Sbjct: 2510 NGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHW--FATTTPIIGKGIMFAI 2567

Query: 2537 KDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGN 2596
            K+G VT  +  +A+EDSR++A++LNNA+YL+ +H++IEG+DTHYF+K+GS + DLV +G 
Sbjct: 2568 KEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGT 2627

Query: 2597 TGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIRYG---TTVEEEKNHVL 2653
            T GR++LE+GVNVTVSQ T ++NGRTRRF +I+ Q+  L  +IRYG    T++EEK  VL
Sbjct: 2628 TIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVL 2687

Query: 2654 EIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLEL 2713
            + ARQRA+  AW KEQ++ ++G EG R WTEGEKQQLLSTGRVQGY+GY+VL VEQY EL
Sbjct: 2688 DQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPEL 2747

Query: 2714 SDSANNIHFMRQSEIGRR 2731
            +DS++NI F+RQ+E+G+R
Sbjct: 2748 ADSSSNIQFLRQNEMGKR 2765


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  209 bits (531), Expect = 4e-53
 Identities = 107/296 (36%), Positives = 146/296 (49%), Gaps = 27/296 (9%)

Query: 530 DCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECD 589
           +C  NC+  G CI G C C  GF G DC++ +CP  C   G+   G C+C  G+ G +C 
Sbjct: 189 ECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCS 248

Query: 590 VPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGW 649
              E C  P    HGTC+ G+C+C  G+ G+ C +  CL+  C N G CV+ EC C  G+
Sbjct: 249 --REICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLN-NCYNRGRCVENECVCDEGF 305

Query: 650 GGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGIC 709
            G +C     +C   C   G  +   G C C+  +TG DC    C   C + G C  G C
Sbjct: 306 TGEDCSE--LICPNDCFDRGRCI--NGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQC 361

Query: 710 QCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCF 769
            C+EG+ G  C E+ C + C   G+C DG+CEC  G+ G  C            CP  C 
Sbjct: 362 VCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELK--------CPNGCS 413

Query: 770 GNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC-CQQ 824
           G+GRC    NG  CVC  G++G  C+   ++ C     ND      CV+  C C+Q
Sbjct: 414 GHGRCV---NG-QCVCDEGYTGEDCS---QLRC----PNDCHSRGRCVEGKCVCEQ 458



 Score =  197 bits (500), Expect = 2e-49
 Identities = 96/267 (35%), Positives = 129/267 (48%), Gaps = 20/267 (7%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C+  G C+ G C C  GF G DC    CP  C G+G    G CVC  G+ G +C  
Sbjct: 377 CPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCS- 435

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWG 650
            + +C +  C   G C+ G C+C  G+KG  C +  C +  C  HG CV G C C  G+ 
Sbjct: 436 -QLRCPND-CHSRGRCVEGKCVCEQGFKGYDCSDMSCPND-CHQHGRCVNGMCVCDDGYT 492

Query: 651 GVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQ 710
           G +C      C   CS  G  L   G C C+  +TG DC+   C  +C   G C  G C 
Sbjct: 493 GEDCRDRQ--CPRDCSNRG--LCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCV 548

Query: 711 CEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFG 770
           C EG++G  C+E+ C S C   G+C DG+C C  G+ G        LD  +  CP  C  
Sbjct: 549 CHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTG--------LDCGQHSCPSDCNN 600

Query: 771 NGRCTLDQNGWHCVCQVGWSGTGCNVV 797
            G+C   +    C+C  G+SG  C+ V
Sbjct: 601 LGQCVSGR----CICNEGYSGEDCSEV 623



 Score =  196 bits (497), Expect = 3e-49
 Identities = 121/382 (31%), Positives = 164/382 (42%), Gaps = 85/382 (22%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGG-NGEYEKGHCVCRHGWKGPECD 589
           C ++CN  G+C++G C CF G+ G DC+R+ CPV C   +G    G CVC  G+ G +C+
Sbjct: 221 CPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCN 280

Query: 590 VP-------------EEQCI---------------DPTCFGHGTCIMGVCICVPGYKGEI 621
            P             E +C+                  CF  G CI G C C  G+ GE 
Sbjct: 281 KPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGED 340

Query: 622 CEEEDCLDPMCSNHGICVKGECHCSTGWGGVNC-ETPLPV-------------------- 660
           C +  C    C   G C +G+C C  G+ GV+C E   P                     
Sbjct: 341 CGKPTC-PHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFT 399

Query: 661 --------CQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCE 712
                   C   CSGHG  +   G C CD  +TG DCS   C  +C S G C  G C CE
Sbjct: 400 GADCGELKCPNGCSGHGRCV--NGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCE 457

Query: 713 EGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRD-GCPGLCFGN 771
           +G+ G  C + SC + C +HG+C +G C C  G+ G+ C         RD  CP  C   
Sbjct: 458 QGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDC---------RDRQCPRDCSNR 508

Query: 772 GRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC-CQQSNCYIS 830
           G C   Q    CVC+ G++G  C    E+ C     ND  G   CV+  C C +   ++ 
Sbjct: 509 GLCVDGQ----CVCEDGFTGPDC---AELSC----PNDCHGQGRCVNGQCVCHEG--FMG 555

Query: 831 PLCQGSPDPLDLIQQSQTLFSQ 852
             C+    P D   Q + +  Q
Sbjct: 556 KDCKEQRCPSDCHGQGRCVDGQ 577



 Score =  167 bits (424), Expect = 1e-40
 Identities = 99/285 (34%), Positives = 128/285 (44%), Gaps = 33/285 (11%)

Query: 540 ECISGHCHCFPGFLGPDCARDSCPVLCGGNGEY--EKGHCVCRHGWKGPECDVPEEQCID 597
           +C +G   C    L P   R      C G G +  E   CVC  GWKGP C  PE     
Sbjct: 139 QCTAGAGCC----LQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPE---CP 191

Query: 598 PTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETP 657
             C   G CI G CIC  G+ GE C +  C    C++ G CV G C C  G+ G +C   
Sbjct: 192 GNCHLRGRCIDGQCICDDGFTGEDCSQLACPSD-CNDQGKCVNGVCICFEGYAGADCSRE 250

Query: 658 LPVCQEQCSG-HGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWV 716
             +C   CS  HGT +   G+C C   + G DC+  LC   C + G C    C C+EG+ 
Sbjct: 251 --ICPVPCSEEHGTCV--DGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFT 306

Query: 717 GPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTL 776
           G  C E  C + C + G+C +G C C  G+ G+ C         +  CP  C   GRC  
Sbjct: 307 GEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCG--------KPTCPHACHTQGRCEE 358

Query: 777 DQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDG---DGLTDCVD 818
            Q    CVC  G++G  C+   E  C  +  N G   DG  +C D
Sbjct: 359 GQ----CVCDEGFAGVDCS---EKRCPADCHNRGRCVDGRCECDD 396



 Score =  116 bits (291), Expect = 3e-25
 Identities = 53/129 (41%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C+  G C+ G C C  GF GPDCA  SCP  C G G    G CVC  G+ G +C  
Sbjct: 501 CPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDC-- 558

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWG 650
            +EQ     C G G C+ G CIC  G+ G  C +  C    C+N G CV G C C+ G+ 
Sbjct: 559 -KEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSD-CNNLGQCVSGRCICNEGYS 616

Query: 651 GVNCETPLP 659
           G +C    P
Sbjct: 617 GEDCSEVSP 625



 Score =  100 bits (250), Expect = 2e-20
 Identities = 56/188 (29%), Positives = 78/188 (41%), Gaps = 41/188 (21%)

Query: 665 CSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERS 724
           CSG G F  +   C C+P W G +CS   C   C   G C  G C C++G+ G  C + +
Sbjct: 161 CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLA 220

Query: 725 CHSHCTEHGQCKDGKCECSPGWEG--------------DHCTIAHYLDAVRDG------- 763
           C S C + G+C +G C C  G+ G              +H T    L    DG       
Sbjct: 221 CPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCN 280

Query: 764 ---CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPD 820
              C   C+  GRC  ++    CVC  G++G  C+   E++C +          DC D  
Sbjct: 281 KPLCLNNCYNRGRCVENE----CVCDEGFTGEDCS---ELICPN----------DCFDRG 323

Query: 821 CCQQSNCY 828
            C    CY
Sbjct: 324 RCINGTCY 331



 Score = 41.6 bits (96), Expect = 0.011
 Identities = 15/33 (45%), Positives = 21/33 (63%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCP 563
           C ++CN  G+C+SG C C  G+ G DC+  S P
Sbjct: 594 CPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPP 626


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  205 bits (522), Expect = 4e-52
 Identities = 107/266 (40%), Positives = 130/266 (48%), Gaps = 20/266 (7%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C G G C+ G C C  GF GPDC++ SCP  C   G  E G CVC  G+ G +C +
Sbjct: 218 CPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCGM 277

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWG 650
              +     C   G C  G C+C PGY GE C    C    CS  G C  G C C  G+ 
Sbjct: 278 ---RSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSC-PRGCSQRGRCKDGRCVCDPGYT 333

Query: 651 GVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQ 710
           G +C T    C   C G G   +D G C C P +TG DCST  C  +C   G C  G C 
Sbjct: 334 GEDCGTRS--CPWDC-GEGGRCVD-GRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECI 389

Query: 711 CEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFG 770
           C+ G+ G  C  RSC   C + G+C+DG+C C PG+ G  C            CP  C G
Sbjct: 390 CDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCG--------SRACPRDCRG 441

Query: 771 NGRCTLDQNGWHCVCQVGWSGTGCNV 796
            GRC   +NG  CVC  G+SG  C V
Sbjct: 442 RGRC---ENG-VCVCNAGYSGEDCGV 463



 Score =  199 bits (506), Expect = 3e-50
 Identities = 110/323 (34%), Positives = 140/323 (43%), Gaps = 43/323 (13%)

Query: 529 DDCST-----NCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGW 583
           +DCST     +C G G C  G C C  G+ G DC   SCP  C   G  E G CVC  G+
Sbjct: 366 EDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGY 425

Query: 584 KGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGEC 643
            G +C     +     C G G C  GVC+C  GY GE C    C    C   G C  G C
Sbjct: 426 TGTDCG---SRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGD-CRGRGRCESGRC 481

Query: 644 HCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGV 703
            C  G+ G +C T    C   C G G  +   G C C+P +TG DC +  C  +C  HG+
Sbjct: 482 MCWPGYTGRDCGTR--ACPGDCRGRGRCV--DGRCVCNPGFTGEDCGSRRCPGDCRGHGL 537

Query: 704 CSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDG 763
           C  G+C C+ G+ G  C  RSC   C   GQC DG+C C  G+ G+ C +          
Sbjct: 538 CEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQ-------- 589

Query: 764 CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQ 823
           CP  C  +G C   Q+G  C+C  G+    C++     C  N    G           C+
Sbjct: 590 CPNDCSQHGVC---QDG-VCICWEGYVSEDCSI---RTCPSNCHGRGR----------CE 632

Query: 824 QSNC-----YISPLCQGSPDPLD 841
           +  C     Y  P C     P D
Sbjct: 633 EGRCLCDPGYTGPTCATRMCPAD 655



 Score =  197 bits (501), Expect = 1e-49
 Identities = 103/291 (35%), Positives = 127/291 (43%), Gaps = 22/291 (7%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C G G C SG C C+PG+ G DC   +CP  C G G    G CVC  G+ G +C  
Sbjct: 466 CPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCG- 524

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWG 650
              +C    C GHG C  GVC+C  GY GE C    C    C   G C+ G C C  G+ 
Sbjct: 525 -SRRC-PGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGG-CRGRGQCLDGRCVCEDGYS 581

Query: 651 GVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQ 710
           G +C   +  C   CS HG  +   GVC C   +   DCS   C   C   G C  G C 
Sbjct: 582 GEDCG--VRQCPNDCSQHG--VCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEGRCL 637

Query: 711 CEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFG 770
           C+ G+ GPTC  R C + C   G+C  G C C  G+ G+ C      +     CPG C  
Sbjct: 638 CDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDC---GQEEPPASACPGGCGP 694

Query: 771 NGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 821
              C   Q    CVC  G+ G  C +            D  G  +C D  C
Sbjct: 695 RELCRAGQ----CVCVEGFRGPDCAI-------QTCPGDCRGRGECHDGSC 734



 Score =  195 bits (495), Expect = 6e-49
 Identities = 96/269 (35%), Positives = 126/269 (46%), Gaps = 25/269 (9%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C G G C+ G C C PGF G DC    CP  C G+G  E G CVC  G+ G +C  
Sbjct: 497 CPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCST 556

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWG 650
              +     C G G C+ G C+C  GY GE C    C +  CS HG+C  G C C  G+ 
Sbjct: 557 ---RSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPND-CSQHGVCQDGVCICWEGYV 612

Query: 651 GVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQ 710
             +C   +  C   C G G    + G C CDP +TG  C+T +C  +C   G C +G+C 
Sbjct: 613 SEDCS--IRTCPSNCHGRGR--CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCL 668

Query: 711 CEEGWVGPTCEER-----SCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCP 765
           C  G+ G  C +      +C   C     C+ G+C C  G+ G  C I          CP
Sbjct: 669 CHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAI--------QTCP 720

Query: 766 GLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
           G C G G C    +   CVC+ G++G  C
Sbjct: 721 GDCRGRGEC----HDGSCVCKDGYAGEDC 745



 Score =  172 bits (437), Expect = 3e-42
 Identities = 102/339 (30%), Positives = 134/339 (39%), Gaps = 51/339 (15%)

Query: 517 QVFVLTTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGH 576
           +V  L   +EI+++         +C  G   C P        +     LC  +G ++   
Sbjct: 99  EVQALRVRLEILEELVKGLKE--QCTGG---CCPASAQAGTGQTDVRTLCSLHGVFDLSR 153

Query: 577 CVC--RHGWKGPECDVPEEQCIDPT------------CFGHGTCIMGVCICVPGYKGEIC 622
           C C    GW GP C  P +  I P+            C   G C+ G C+C PGY G  C
Sbjct: 154 CTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSC 213

Query: 623 EEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDP 682
               C    C   G CV+G C C  G+ G +C      C   CS  G    + G C CDP
Sbjct: 214 GWPSCPGD-CQGRGRCVQGVCVCRAGFSGPDCSQRS--CPRGCSQRGR--CEGGRCVCDP 268

Query: 683 KWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCEC 742
            +TG DC    C   C   G C  G C C  G+ G  C  RSC   C++ G+CKDG+C C
Sbjct: 269 GYTGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVC 328

Query: 743 SPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVM---- 798
            PG+ G+ C            CP  C   GRC        CVC  G++G  C+       
Sbjct: 329 DPGYTGEDCGTR--------SCPWDCGEGGRCV----DGRCVCWPGYTGEDCSTRTCPRD 376

Query: 799 ----------EMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
                     E +C      D  G+  C   DC Q+  C
Sbjct: 377 CRGRGRCEDGECICDTGYSGDDCGVRSC-PGDCNQRGRC 414



 Score =  143 bits (361), Expect = 2e-33
 Identities = 71/202 (35%), Positives = 93/202 (46%), Gaps = 14/202 (6%)

Query: 529 DDCSTN-----CNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGW 583
           +DCST      C G G+C+ G C C  G+ G DC    CP  C  +G  + G C+C  G+
Sbjct: 552 EDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGY 611

Query: 584 KGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGEC 643
              +C +   +     C G G C  G C+C PGY G  C    C    C   G CV+G C
Sbjct: 612 VSEDCSI---RTCPSNCHGRGRCEEGRCLCDPGYTGPTCATRMC-PADCRGRGRCVQGVC 667

Query: 644 HCSTGWGGVNC---ETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGS 700
            C  G+GG +C   E P   C   C      L  AG C C   + G DC+ + C  +C  
Sbjct: 668 LCHVGYGGEDCGQEEPPASACPGGCGPRE--LCRAGQCVCVEGFRGPDCAIQTCPGDCRG 725

Query: 701 HGVCSRGICQCEEGWVGPTCEE 722
            G C  G C C++G+ G  C E
Sbjct: 726 RGECHDGSCVCKDGYAGEDCGE 747



 Score =  118 bits (295), Expect = 9e-26
 Identities = 58/171 (33%), Positives = 82/171 (47%), Gaps = 11/171 (6%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C  +C+ +G C  G C C+ G++  DC+  +CP  C G G  E+G C+C  G+ GP C  
Sbjct: 590 CPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEGRCLCDPGYTGPTCAT 649

Query: 591 PEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEED----CLDPMCSNHGICVKGECHCS 646
              +     C G G C+ GVC+C  GY GE C +E+         C    +C  G+C C 
Sbjct: 650 ---RMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCV 706

Query: 647 TGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTME 697
            G+ G +C   +  C   C G G      G C C   + G DC  E+ T+E
Sbjct: 707 EGFRGPDCA--IQTCPGDCRGRGE--CHDGSCVCKDGYAGEDCGEEVPTIE 753


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score =  148 bits (374), Expect = 6e-35
 Identities = 89/278 (32%), Positives = 118/278 (42%), Gaps = 30/278 (10%)

Query: 562  CPVLCGGNGEYEKGH-CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIM-GVCICVPGYKG 619
            C   CG + E    + C C+ G+ G  C   +    DP C  HG CI   +C C+PG+ G
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNC---QTALCDPDCKNHGKCIKPNICQCLPGHGG 1354

Query: 620  EICEEEDCLDPMCSNHGICVKGE-CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVC 678
              C+EE C +P C + G C+ G  C C  G+ G  CET   VC   C   G   L   +C
Sbjct: 1355 ATCDEEHC-NPPCQHGGTCLAGNLCTCPYGFVGPRCET--MVCNRHCENGGQ-CLTPDIC 1410

Query: 679  SCDPKWTGSDCSTELCTMECGSHGVCSR-GICQCEEGWVGPTCEERSCHSHCTEHGQC-K 736
             C P W G  CST LC   C + G C++   C C  G+ G  C+   CH  C   G C +
Sbjct: 1411 QCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMR 1470

Query: 737  DGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
            +  C C  G+ G            +  C   C   G+C        C C  GWSG  CN 
Sbjct: 1471 NNVCVCREGYTGRRFQ--------KSICDPTCMNGGKCVGPST---CSCPSGWSGKRCNT 1519

Query: 797  VMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
                +C     N G    +C+ P  C   + +    CQ
Sbjct: 1520 ---PICLQKCKNGG----ECIAPSICHCPSSWEGVRCQ 1550



 Score =  135 bits (339), Expect = 7e-31
 Identities = 91/310 (29%), Positives = 123/310 (39%), Gaps = 31/310 (10%)

Query: 531  CSTNCNGNGECISGH-CHCFPGFLGPDCARDSCPVLCGGNGEYEKGH-CVCRHGWKGPEC 588
            C   C  + EC++ + C C PG++G +C    C   C  +G+  K + C C  G  G  C
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATC 1357

Query: 589  DVPEEQCIDPTCFGHGTCIMG-VCICVPGYKGEICEEEDCLDPMCSNHGICVKGE-CHCS 646
            D  EE C +P C   GTC+ G +C C  G+ G  CE   C +  C N G C+  + C C 
Sbjct: 1358 D--EEHC-NPPCQHGGTCLAGNLCTCPYGFVGPRCETMVC-NRHCENGGQCLTPDICQCK 1413

Query: 647  TGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSR 706
             GW G  C T L  C   C   G+       C C   + G  C    C   C + G C R
Sbjct: 1414 PGWYGPTCSTAL--CDPVCLNGGS-CNKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMR 1470

Query: 707  -GICQCEEGWVGPTCEERSCHSHCTEHGQC-KDGKCECSPGWEGDHCTIAHYLDAVRDGC 764
              +C C EG+ G   ++  C   C   G+C     C C  GW G  C     L   ++G 
Sbjct: 1471 NNVCVCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNG- 1529

Query: 765  PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQ 824
                   G C        C C   W G  C +    +C       G     C+ P+ C  
Sbjct: 1530 -------GECIAPS---ICHCPSSWEGVRCQI---PICNPKCLYGG----RCIFPNVCSC 1572

Query: 825  SNCYISPLCQ 834
               Y    C+
Sbjct: 1573 RTEYSGVKCE 1582



 Score =  128 bits (321), Expect = 9e-29
 Identities = 71/229 (31%), Positives = 99/229 (43%), Gaps = 13/229 (5%)

Query: 529  DDCSTNCNGNGECISGH-CHCFPGFLGPDCARDSCPVLCGGNGE-YEKGHCVCRHGWKGP 586
            + C+  C   G C++G+ C C  GF+GP C    C   C   G+      C C+ GW GP
Sbjct: 1360 EHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGP 1419

Query: 587  ECDVPEEQCIDPTCFGHGTCIM-GVCICVPGYKGEICEEEDCLDPMCSNHGICVKGE-CH 644
             C        DP C   G+C     C+C  G+ GE C+   C  P C N G C++   C 
Sbjct: 1420 TCSTA---LCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFC-HPPCKNGGHCMRNNVCV 1475

Query: 645  CSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVC 704
            C  G+ G   +    +C   C   G   +    CSC   W+G  C+T +C  +C + G C
Sbjct: 1476 CREGYTGRRFQKS--ICDPTCMNGGK-CVGPSTCSCPSGWSGKRCNTPICLQKCKNGGEC 1532

Query: 705  -SRGICQCEEGWVGPTCEERSCHSHCTEHGQC-KDGKCECSPGWEGDHC 751
             +  IC C   W G  C+   C+  C   G+C     C C   + G  C
Sbjct: 1533 IAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKC 1581



 Score =  119 bits (299), Expect = 3e-26
 Identities = 97/346 (28%), Positives = 124/346 (35%), Gaps = 73/346 (21%)

Query: 499  MDQGPWYLAFYNDGKKMEQVFVLTT---AIEIMDDCSTNCNGNGECISGHCHCFPGFLGP 555
            +D GP   +  + G  M +  +LTT    + + DDC        E     C C  G    
Sbjct: 1131 LDSGPEGASVSSAGLFMWKTDLLTTQQITVRLNDDCDAETRVTIEVTVKSCDCLNG---G 1187

Query: 556  DCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----C 611
             C  D       G+G Y    CVC  G+ G  C+V    C    C G G+ I G     C
Sbjct: 1188 SCVSDRN--FSPGSGVYL---CVCLPGFHGSLCEVDISGCQSNPC-GLGSYISGFHSYSC 1241

Query: 612  ICVPGYKGE--------------------ICEEED---------------------CLDP 630
             C P  K E                    + +EED                     C  P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301

Query: 631  MCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCS 690
               +        C C  G+ G NC+T L  C   C  HG   +   +C C P   G+ C 
Sbjct: 1302 CGKSRECVAPNICKCKPGYIGSNCQTAL--CDPDCKNHGK-CIKPNICQCLPGHGGATCD 1358

Query: 691  TELCTMECGSHGVCSRG-ICQCEEGWVGPTCEERSCHSHCTEHGQC-KDGKCECSPGWEG 748
             E C   C   G C  G +C C  G+VGP CE   C+ HC   GQC     C+C PGW G
Sbjct: 1359 EEHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYG 1418

Query: 749  DHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
              C+ A         C  +C   G C        C+C  G+ G  C
Sbjct: 1419 PTCSTAL--------CDPVCLNGGSCNKPNT---CLCPNGFFGEHC 1453



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 57/199 (28%), Positives = 84/199 (42%), Gaps = 43/199 (21%)

Query: 531  CSTNCNGNGECISGH-CHCFPGFLGPDCARDSCPVLCGGNGEYEK--------------- 574
            C+ +C   G+C++   C C PG+ GP C+   C  +C   G   K               
Sbjct: 1394 CNRHCENGGQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHC 1453

Query: 575  ------------GHC------VCRHGWKGPECDVPEEQCIDPTCFGHGTCI-MGVCICVP 615
                        GHC      VCR G+ G      ++   DPTC   G C+    C C  
Sbjct: 1454 QNAFCHPPCKNGGHCMRNNVCVCREGYTGRRF---QKSICDPTCMNGGKCVGPSTCSCPS 1510

Query: 616  GYKGEICEEEDCLDPMCSNHGICVKGE-CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLD 674
            G+ G+ C    CL   C N G C+    CHC + W GV C+  +P+C  +C  +G   + 
Sbjct: 1511 GWSGKRCNTPICLQK-CKNGGECIAPSICHCPSSWEGVRCQ--IPICNPKCL-YGGRCIF 1566

Query: 675  AGVCSCDPKWTGSDCSTEL 693
              VCSC  +++G  C  ++
Sbjct: 1567 PNVCSCRTEYSGVKCEKKI 1585



 Score = 40.0 bits (92), Expect = 0.032
 Identities = 23/74 (31%), Positives = 31/74 (41%), Gaps = 12/74 (16%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDV 590
           C   C+GNG+C+   C C P F   DC           +  Y+K   +   G  G  CDV
Sbjct: 890 CPNLCSGNGQCMEWGCACSPSFSSYDC-----------SDSYDKAPEITELGNAG-FCDV 937

Query: 591 PEEQCIDPTCFGHG 604
            +  C+    FG G
Sbjct: 938 QKYNCMMVRVFGKG 951



 Score = 33.1 bits (74), Expect = 3.9
 Identities = 13/32 (40%), Positives = 16/32 (50%), Gaps = 4/32 (12%)

Query: 764 CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCN 795
           CP LC GNG+C      W C C   +S   C+
Sbjct: 890 CPNLCSGNGQCM----EWGCACSPSFSSYDCS 917


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  147 bits (372), Expect = 1e-34
 Identities = 98/310 (31%), Positives = 135/310 (43%), Gaps = 46/310 (14%)

Query: 528  MDDCSTN-CNGNGEC---ISGH-CHCFPGFLGPDCARDSCP---------VLCGGNGEYE 573
            +D+C++N C   G C   ISG+ CHC   + G +C     P          +C  +  +E
Sbjct: 796  IDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFE 855

Query: 574  KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC--IMG--VCICVPGYKGEICEE--EDC 627
               C+C  GW+G  C +  ++CI   C  HG C    G  +C C PG+ G  CEE  +DC
Sbjct: 856  SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDC 915

Query: 628  LDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVC-QEQCSGHGTF--LLDAGVCSC 680
            L   C N G C+ G     C C  G+ G  C+T +  C  E C   GT    +++  C C
Sbjct: 916  LANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKC 975

Query: 681  DPKWTGSDCSTEL--CT-MECGSHGVCSRGI----CQCEEGWVGPTC--EERSCHSH-CT 730
               + G  C   +  CT   C + G C  GI    C C  G+ G  C  E   C SH C 
Sbjct: 976  QAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCL 1035

Query: 731  EHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQ 786
              G C DG    +C C  G+ G +C     L +        C   G C   +    C+C 
Sbjct: 1036 NEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCS-----RSPCKNKGTCVQKKAESQCLCP 1090

Query: 787  VGWSGTGCNV 796
             GW+G  C+V
Sbjct: 1091 SGWAGAYCDV 1100



 Score =  132 bits (331), Expect = 6e-30
 Identities = 96/342 (28%), Positives = 135/342 (39%), Gaps = 64/342 (18%)

Query: 528  MDDCSTN-CNGNGECISG----HCHCFPGFLGPDCARD-----SCPVLCGG-NGEYEKGH 576
            +D+C++N C     CI+G     C C  G   P C        S P + G   G      
Sbjct: 683  IDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYK 742

Query: 577  CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDCLDP 630
            C+C  GW G  C+V + +C+   C   GTC   V    C C  G+KG  C+   ++C   
Sbjct: 743  CLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASN 802

Query: 631  MCSNHGIC---VKG-ECHCSTGWGGVNCETPLPVCQEQ-------CSGHGTFLLDAGVCS 679
             C N G C   + G  CHC   + G NC+T L  C          C     F  ++  C 
Sbjct: 803  PCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNF--ESYTCL 860

Query: 680  CDPKWTGSDCS---TELCTMECGSHGVCSRG----ICQCEEGWVGPTCEE--RSCHSH-C 729
            C P W G  C+    E  +  C +HG+C       +C+C  G+ G  CEE    C ++ C
Sbjct: 861  CAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPC 920

Query: 730  TEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVC 785
               G C DG     C C PG+ GD C        + +     C   G C+   N + C C
Sbjct: 921  QNGGSCMDGVNTFSCLCLPGFTGDKCQ-----TDMNECLSEPCKNGGTCSDYVNSYTCKC 975

Query: 786  QVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
            Q G+ G  C                + + +C +  C     C
Sbjct: 976  QAGFDGVHCE---------------NNINECTESSCFNGGTC 1002



 Score =  129 bits (323), Expect = 5e-29
 Identities = 90/292 (30%), Positives = 120/292 (41%), Gaps = 63/292 (21%)

Query: 531 CSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKG----------HCVCR 580
           C TN   NG+ I   C C  G+ G DC  D        +   E            HC C 
Sbjct: 390 CDTNPL-NGQYI---CTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECL 445

Query: 581 HGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE--DCLDPMCSN 634
            G+ GP C++   +C    C    TC+  +    C+C+PG+KG  CE E  +C    C N
Sbjct: 446 KGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN 505

Query: 635 HGICV----KGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCS 690
           +G CV    + +C C  G+ G       PVCQ          +D   CS  P   G+ C 
Sbjct: 506 NGQCVDKVNRFQCLCPPGFTG-------PVCQ----------IDIDDCSSTPCLNGAKCI 548

Query: 691 TELCTMECGSHGVCSRGICQCEEGWVGPTCEER--SCHSHCTEHGQCKDG----KCECSP 744
                 EC           QC  G+ G  CEE   +C      HGQC+DG     C C+P
Sbjct: 549 DHPNGYEC-----------QCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNP 597

Query: 745 GWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
           G+ G  C+     D + +     C  +GRC    NG+ C CQ G SG  C +
Sbjct: 598 GYMGAICS-----DQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI 644



 Score =  127 bits (320), Expect = 1e-28
 Identities = 102/340 (30%), Positives = 125/340 (36%), Gaps = 68/340 (20%)

Query: 535 CNGNGECIS-----GHCHCFPGFLGPDCA-RDSCPV-------LCGGNGEYEKGHCVCRH 581
           C   G C++     G+C C  GFLG  C  RD C          C       K  C C  
Sbjct: 35  CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94

Query: 582 GWKGPECDVPEEQ--CIDPTCFGHGTCIM-----GVCICVPGYKGEICEEED-CLDPMCS 633
           G+ G +C         +   C   GTC M       C C  G+ G+ C+  D CL   C+
Sbjct: 95  GFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCA 154

Query: 634 NHGICV----KGECHCSTGWGGVNCETPLPVCQ--EQCSGHGTFLLDAGV--CSCDPKWT 685
           N   C     +  C C TG+ G  CET +  C     C   GT L   G   C C   +T
Sbjct: 155 NGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT 214

Query: 686 GSDCST---ELCTMECGSHGVCSRG-----ICQCEEGWVGPTCEER--SCHSH-CTEHGQ 734
           G  C +         C + G C +       C C  G+ G TCE     C +H C   G 
Sbjct: 215 GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGV 274

Query: 735 CKDG----KCECSPGWEGDHCTIAHYLDAVRDGC---PGLCFGNGRCTLDQNGWHCVCQV 787
           C DG     C C P W G  CT         D C   P  C   G C     G+ CVC  
Sbjct: 275 CVDGVNTYNCRCPPQWTGQFCT------EDVDECLLQPNACQNGGTCANRNGGYGCVCVN 328

Query: 788 GWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
           GWSG  C+        +N+D       DC    C   S C
Sbjct: 329 GWSGDDCS--------ENID-------DCAFASCTPGSTC 353



 Score =  125 bits (313), Expect = 7e-28
 Identities = 97/334 (29%), Positives = 137/334 (41%), Gaps = 56/334 (16%)

Query: 528 MDDC-STNCNGNGECI---SGH-CHCFPGFLG-------PDCARDSC--PVLCGGNGEYE 573
           +D+C S+ C  +G CI   +G+ C+C PG  G        DCA + C   +   G   Y 
Sbjct: 608 IDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYS 667

Query: 574 KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEIC--EEEDC 627
              CVC  G+ G  C++  ++C    C    TCI GV    CIC  G     C  +  +C
Sbjct: 668 ---CVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNEC 724

Query: 628 LDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVC-QEQCSGHGTF--LLDAGVCSC 680
           L   C  HG C  G    +C C  GW G+NCE     C    C   GT   L++   C+C
Sbjct: 725 LSNPCI-HGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTC 783

Query: 681 DPKWTGSDCST---ELCTMECGSHGVCSRGI----CQCEEGWVGPTCEE--RSCHSH-CT 730
              + G +C     E  +  C + G C   I    C C   + G  C+     C  + C 
Sbjct: 784 KKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE 843

Query: 731 EHGQCKDG------KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCV 784
               CK+        C C+PGW+G  CTI      + +     C  +G C   Q  + C 
Sbjct: 844 NAAVCKESPNFESYTCLCAPGWQGQRCTI-----DIDECISKPCMNHGLCHNTQGSYMCE 898

Query: 785 CQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVD 818
           C  G+SG  C   ++    +   N G     C+D
Sbjct: 899 CPPGFSGMDCEEDIDDCLANPCQNGG----SCMD 928



 Score =  121 bits (303), Expect = 1e-26
 Identities = 96/345 (27%), Positives = 135/345 (39%), Gaps = 66/345 (19%)

Query: 528 MDDCSTN-CNGNGECISG----HCHCFPGFLGPDCARD--SC---PVLCGGNGEYEKGH- 576
           +DDC  + C   G C+ G    +C C P + G  C  D   C   P  C   G     + 
Sbjct: 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNG 320

Query: 577 ---CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEED-CL 628
              CVC +GW G +C    + C   +C    TCI  V    C+C  G  G +C  +D C+
Sbjct: 321 GYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACI 380

Query: 629 DPMCSNHGIC----VKGE--CHCSTGWGGVNCETPLPVC----QEQCSGHGTFLLDAGV- 677
              C    +C    + G+  C C  G+ G +C   +  C       C   G  +   G  
Sbjct: 381 SNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAF 440

Query: 678 -CSCDPKWTGSDCSTEL--CTME-CGSHGVCSRGI----CQCEEGWVGPTC--EERSCHS 727
            C C   + G  C  ++  C  + C +   C   I    C C  G+ G  C  E   C S
Sbjct: 441 HCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQS 500

Query: 728 H-CTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWH 782
           + C  +GQC D     +C C PG+ G  C I      + D     C    +C    NG+ 
Sbjct: 501 NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQI-----DIDDCSSTPCLNGAKCIDHPNGYE 555

Query: 783 CVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
           C C  G++G        +LC +N+DN         DPD C    C
Sbjct: 556 CQCATGFTG--------VLCEENIDN--------CDPDPCHHGQC 584



 Score =  120 bits (302), Expect = 1e-26
 Identities = 110/373 (29%), Positives = 144/373 (38%), Gaps = 80/373 (21%)

Query: 528  MDDCSTN-CNGNGECISG----HCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCV---- 578
            +++CS++ C   G C+ G     C C  G+ G +C   +   LC  +    KG CV    
Sbjct: 1026 INECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNC--QTLVNLCSRSPCKNKGTCVQKKA 1083

Query: 579  -----CRHGWKGPECDVPEEQC----------IDPTCFGHGTCIMG----VCICVPGYKG 619
                 C  GW G  CDVP   C          ++  C   G CI       C C  GY G
Sbjct: 1084 ESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTG 1143

Query: 620  EICEE--EDCLDPMCSNHGIC---VKG-ECHCSTGWGGVNCETPLPVCQEQ-CSGHGTF- 671
              CEE  ++C    C +   C   + G  C C  G+ GVNCE  +  CQ Q C   GT  
Sbjct: 1144 SYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI 1203

Query: 672  -LLDAGVCSCDPKWTGSDCSTELCTMECGSH----GVCSRGI----CQCEEGWVGPTCEE 722
             L++   CSC P   G  C   +     G H    G C   I    C+C  G+ G  CE 
Sbjct: 1204 DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEG 1263

Query: 723  --RSCHSH-CTEHGQ------CKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNG 772
                C S+ C+  G         D  C C   + G HC      +   D CP + C   G
Sbjct: 1264 DINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHC------ETFVDVCPQMPCLNGG 1317

Query: 773  RCTLDQN---GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTD--------CVDPDC 821
             C +  N   G+ C C  G+SG  C    +  CG      G+            C  P  
Sbjct: 1318 TCAVASNMPDGFICRCPPGFSGARC----QSSCGQVKCRKGEQCVHTASGPRCFCPSPRD 1373

Query: 822  CQQSNCYISPLCQ 834
            C +S C  SP CQ
Sbjct: 1374 C-ESGCASSP-CQ 1384



 Score =  103 bits (256), Expect = 3e-21
 Identities = 96/351 (27%), Positives = 140/351 (39%), Gaps = 68/351 (19%)

Query: 526  EIMDDCSTN-CNGNGEC---ISGH-CHCFPGFLGPDCAR--DSC---PVLCGGNGEYEKG 575
            E +D+C++N C     C   I G+ C C PG+ G +C    D C   P   GG       
Sbjct: 1148 EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVN 1207

Query: 576  H--CVCRHGWKGPECDVPEEQCI-DPTCFGHGTCIMGV----CICVPGYKGEICEEE--D 626
            H  C C  G +G  C+   + C   P C   G C+  +    C C+PG+ GE CE +  +
Sbjct: 1208 HFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINE 1267

Query: 627  CLDPMCSNHGI--CVKGE----CHCSTGWGGVNCETPLPVC-QEQCSGHGTFLL-----D 674
            CL   CS+ G   C++      C C + + G +CET + VC Q  C   GT  +     D
Sbjct: 1268 CLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD 1327

Query: 675  AGVCSCDPKWTGSDCSTELCTMECGSHGVC----SRGICQCEEGWVGPTCEERSCHSHCT 730
              +C C P ++G+ C +    ++C     C    S   C C        CE     S C 
Sbjct: 1328 GFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSP---RDCESGCASSPCQ 1384

Query: 731  EHGQCKDGK------CECSPGWEGDHCTIAHYLDAVRDGCPGLCFG--------NGRCTL 776
              G C   +      C+C+P + G  C +     A     P  C          +G C  
Sbjct: 1385 HGGSCHPQRQPPYYSCQCAPPFSGSRCEL---YTAPPSTPPATCLSQYCADKARDGVCDE 1441

Query: 777  DQNGWHCVCQVGWSGTGCNVVME---------MLCGDNLDNDGDGLTDCVD 818
              N   C     W G  C++ ME         + C D ++N  D L + V+
Sbjct: 1442 ACNSHAC----QWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVE 1488


>gi|4758614 integrin, beta-like 1 (with EGF-like repeat domains)
           [Homo sapiens]
          Length = 494

 Score =  144 bits (364), Expect = 9e-34
 Identities = 107/345 (31%), Positives = 135/345 (39%), Gaps = 91/345 (26%)

Query: 535 CNGNGECISGHCHC------------FPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHG 582
           C+  G C  G C C            F      +C  D    +CGG+G+   G+C C+ G
Sbjct: 151 CSNAGTCHCGRCKCDNSDGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAG 210

Query: 583 WKGPECDVP--------EEQCIDPT---CFGHGTCIMGVCIC----VPGYKGEI------ 621
           W G +C+          + +C  P    C   GTC+ G C C      G  G+I      
Sbjct: 211 WHGDKCEFQCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCE 270

Query: 622 CEEEDCL-------DPMCSNHGICVKGECHCSTGWGGVNCETP----------LPVCQEQ 664
           C+E DC        D  CS HG C  G C C  GW G  CE P          +  CQ  
Sbjct: 271 CDERDCRAVYDRYSDDFCSGHGQCNCGRCDCKAGWYGKKCEHPQSCTLSAEESIRKCQGS 330

Query: 665 ----CSGHGTFLLDAGVCSCDP----KWTGSDCSTE------LCTMECGSHGVCSRGICQ 710
               CSG G    + G C+C P    +  G  C  +      L  + CG HG CS G C 
Sbjct: 331 SDLPCSGRGK--CECGKCTCYPPGDRRVYGKTCECDDRRCEDLDGVVCGGHGTCSCGRCV 388

Query: 711 CEEGWVGPTC---------EERS---CHSH----CTEHGQCKDGKCECS-PGW--EGDHC 751
           CE GW G  C         EE+S   C S     C+  G C  GKC CS   W   G+ C
Sbjct: 389 CERGWFGKLCQHPRKCNMTEEQSKNLCESADGILCSGKGSCHCGKCICSAEEWYISGEFC 448

Query: 752 TIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
                     DG   +C GNG C+      +C C  GW+G  C +
Sbjct: 449 DCDDRDCDKHDGL--ICTGNGICSCG----NCECWDGWNGNACEI 487



 Score =  133 bits (335), Expect = 2e-30
 Identities = 110/385 (28%), Positives = 138/385 (35%), Gaps = 99/385 (25%)

Query: 535 CNGNGECISGHCHCF---PG-FLGP--DCARDSCPVL----CGGNGEYEKGHCVCRHGWK 584
           C+G G C  G C C    PG F GP  +C    C       C G+G+ + G C C  GW 
Sbjct: 63  CHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQGWY 122

Query: 585 GPECDVP----------EEQC---IDPTCFGHGTCIMGVCIC--------VPGYKGEICE 623
           G  C  P           + C    D  C   GTC  G C C        V G   E C+
Sbjct: 123 GDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCE-CD 181

Query: 624 EEDCLD----PMCSNHGICVKGECHCSTGWGGVNCE-----TPLPVCQEQCSGHGTFLLD 674
           + +C+D     +C  HG C  G C+C  GW G  CE     TP    +   S  G    +
Sbjct: 182 DRECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKICSN 241

Query: 675 AGVCSC--------DPKWTGSDCSTELCTME---------------CGSHGVCSRGICQC 711
            G C C        DP     D   + C  +               C  HG C+ G C C
Sbjct: 242 RGTCVCGECTCHDVDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCGRCDC 301

Query: 712 EEGWVGPTCEE------------RSCHSH----CTEHGQCKDGKCECSPGWEGDHCTIAH 755
           + GW G  CE             R C       C+  G+C+ GKC C P   GD      
Sbjct: 302 KAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLPCSGRGKCECGKCTCYP--PGDRRVYGK 359

Query: 756 YLDAVRDGCPGL----CFGNGRCTLDQNGWHCVCQVGWSG------TGCNVVMEMLCGDN 805
             +     C  L    C G+G C+  +    CVC+ GW G        CN+  E     N
Sbjct: 360 TCECDDRRCEDLDGVVCGGHGTCSCGR----CVCERGWFGKLCQHPRKCNMTEEQ--SKN 413

Query: 806 LDNDGDGLTDCVDPDCCQQSNCYIS 830
           L    DG+  C     C    C  S
Sbjct: 414 LCESADGIL-CSGKGSCHCGKCICS 437



 Score =  108 bits (270), Expect = 7e-23
 Identities = 99/351 (28%), Positives = 126/351 (35%), Gaps = 94/351 (26%)

Query: 565 LCGGNGEYEKGHCVCR----HGWKGPECDVPEEQC---IDPTCFGHGTCIMGVCICVPGY 617
           LC G G  + G C+C       + GP C+  E  C      TC GHG C  G C C  G+
Sbjct: 62  LCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQGW 121

Query: 618 KGEICEE---------------EDCLDPMCSNHGICVKGECHCSTGWG-----GVNCETP 657
            G+ C+                ++  D +CSN G C  G C C    G     G  CE  
Sbjct: 122 YGDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCECD 181

Query: 658 LPVC-----QEQCSGHGTFLLDAGVCSCDPKWTGSDC----------STELCTME----C 698
              C     +E C GHG      G C C   W G  C          S   CT      C
Sbjct: 182 DRECIDDETEEICGGHGKCY--CGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKIC 239

Query: 699 GSHGVCSRGICQCEEGWVGPT------------CEERSCHS--------HCTEHGQCKDG 738
            + G C  G C C +  V PT            C+ER C +         C+ HGQC  G
Sbjct: 240 SNRGTCVCGECTCHD--VDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCG 297

Query: 739 KCECSPGWEG------DHCTIAHYLDAVRDGCPGL----CFGNGRCTLDQNGWHCVCQVG 788
           +C+C  GW G        CT++   +++R  C G     C G G+C   +    C C   
Sbjct: 298 RCDCKAGWYGKKCEHPQSCTLSAE-ESIRK-CQGSSDLPCSGRGKCECGK----CTCYPP 351

Query: 789 WSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC-----YISPLCQ 834
                     E  C D    D DG+  C     C    C     +   LCQ
Sbjct: 352 GDRRVYGKTCE--CDDRRCEDLDGVV-CGGHGTCSCGRCVCERGWFGKLCQ 399



 Score = 96.3 bits (238), Expect = 4e-19
 Identities = 85/283 (30%), Positives = 106/283 (37%), Gaps = 78/283 (27%)

Query: 583 WKGPECDVP----EEQCIDP-------TCFGHGTCIMGVCIC---VPG-YKGEICEEEDC 627
           W G  C +     E +C  P        C G G C  GVCIC    PG + G +CE  + 
Sbjct: 35  WPGAACRLSRAESERRCRAPGQPPGAALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEW 94

Query: 628 L-----DPMCSNHGICVKGECHCSTGWGGVNCETPL----------PVCQEQ----CSGH 668
           +        C+ HG C  G+C C  GW G  C+ P            +C+      CS  
Sbjct: 95  VCETYDGSTCAGHGKCDCGKCKCDQGWYGDACQYPTNCDLTKKKSNQMCKNSQDIICSNA 154

Query: 669 GTFLLDAGVCSCDPKWTGS--------DCSTELCTME-----CGSHGVCSRGICQCEEGW 715
           GT     G C CD    GS        +C    C  +     CG HG C  G C C+ GW
Sbjct: 155 GT--CHCGRCKCDNS-DGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAGW 211

Query: 716 VGPTCE----------ERSCHSH----CTEHGQCKDGKCEC-----SPGW---EGDHCTI 753
            G  CE          +R C S     C+  G C  G+C C     +  W    GD C  
Sbjct: 212 HGDKCEFQCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCEC 271

Query: 754 -AHYLDAVRDG-CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
                 AV D      C G+G+C    N   C C+ GW G  C
Sbjct: 272 DERDCRAVYDRYSDDFCSGHGQC----NCGRCDCKAGWYGKKC 310


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  143 bits (360), Expect = 3e-33
 Identities = 100/362 (27%), Positives = 152/362 (41%), Gaps = 60/362 (16%)

Query: 529 DDCSTN-CNGNGEC----ISGH--CHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCV--- 578
           D C +N CN    C    ++G   C C  G+ GP C++D      G N     G C+   
Sbjct: 374 DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTL 433

Query: 579 ------CRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICE--EED 626
                 C  G+ GP C++   +C+   C    TC+  +    CIC+PGY+G  CE   ++
Sbjct: 434 GSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDE 493

Query: 627 CLDPMCSNHGICV----KGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG---VCS 679
           C    C ++G C+    + +C C TG+ G  C+  +  C      +G   LD      C 
Sbjct: 494 CASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCV 553

Query: 680 CDPKWTGSDCSTEL--CTMECGSHGVCSRGI----CQCEEGWVGPTCEER--SCHSH-CT 730
           C   +TG+ C  ++  C  +   +G C  G+    C C  G+ G  CE     C S  C 
Sbjct: 554 CTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCR 613

Query: 731 EHGQCKDGK----CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQ 786
             G C+D      C C  G  G +C I        D C      +G C    +G+ C C+
Sbjct: 614 HGGTCQDRDNAYLCFCLKGTTGPNCEIN------LDDCASSPCDSGTCLDKIDGYECACE 667

Query: 787 VGWSGTGCNVVMEMLCGDNLDNDG---DGLTDCV--------DPDCCQQSN-CYISPLCQ 834
            G++G+ CN+ ++   G+   N G   DG+            DP C  + N C  +P   
Sbjct: 668 PGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVH 727

Query: 835 GS 836
           G+
Sbjct: 728 GA 729



 Score =  138 bits (347), Expect = 9e-32
 Identities = 105/368 (28%), Positives = 152/368 (41%), Gaps = 64/368 (17%)

Query: 535  CNGNGECISGH------CHCFPGFLGPDCARD--SC---PVLCGGNGEYEKG--HCVCRH 581
            C   GEC          C C  G+ G  C  D   C   P   G + +   G   C C+ 
Sbjct: 838  CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQA 897

Query: 582  GWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE--DCLDPMCSNH 635
            G+ G  C+   + C    C   G+C  G+    C C+PG++G  CEE+  +C    C N 
Sbjct: 898  GYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNG 957

Query: 636  GICV----KGECHCSTGWGGVNCETPLPVCQEQ-CSGHGTFL--LDAGVCSCDPKWTGSD 688
              C        C C  G+ G++CE   P C E  C   GT +  +++  C C P +TGS 
Sbjct: 958  ANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1017

Query: 689  CS---TELCTMECGSHGVCSRGI----CQCEEGWVGPTCEERSCHSHCTEHGQCKDG--- 738
            C     E  +  C   G C  G     C C +G+ GP C+      H  +   CK+G   
Sbjct: 1018 CQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV---HWCDSSPCKNGGKC 1074

Query: 739  -------KCECSPGWEGDHC---TIAHYLDAVRDGCP--GLCFGNGRCTLDQNGWHCVCQ 786
                   +CEC  GW G +C   +++  + A R G     LC   G C    N  HC CQ
Sbjct: 1075 WQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQ 1134

Query: 787  VGWSGTGCNVVMEMLCGDNLDNDGDGLTD--------CV----DPDCCQQSNCYISPLCQ 834
             G++G+ C  +++  C  +   +G   TD        CV      +C ++ +  +S  CQ
Sbjct: 1135 AGYTGSYCEDLVDE-CSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQ 1193

Query: 835  GSPDPLDL 842
                 LDL
Sbjct: 1194 NGGTCLDL 1201



 Score =  136 bits (342), Expect = 3e-31
 Identities = 116/396 (29%), Positives = 153/396 (38%), Gaps = 93/396 (23%)

Query: 529 DDCSTN-CNGNGECI----SGHCHCFPGFLGPDCARD--SC---PVLC--GGNGEYEKG- 575
           D C++N C   G+C+    S  CHC P F GP C +D   C   P LC  GG    E G 
Sbjct: 142 DPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGS 201

Query: 576 -HCVCRHGWKGPECDVPEEQCIDPTCFGHGTC-----IMGVCICVPGYKGEICEE--EDC 627
             CVCR    GP C+ P   C    C   GTC     +   C C+PG+ G+ CEE  +DC
Sbjct: 202 YRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDC 261

Query: 628 LDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQ---EQCSGHGTFLLDAG--VC 678
               C N G CV G     C C   W G  C   +  CQ     C   GT     G   C
Sbjct: 262 PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNC 321

Query: 679 SCDPKWTGSDCSTE---------------------------------LCTM--------- 696
            C   WTG DCS                                   LC +         
Sbjct: 322 VCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPC 381

Query: 697 ----ECGSHGVCSRGICQCEEGWVGPTC----EERSCHSHCTEH-GQCKDG----KCECS 743
                C ++ V  + IC C  G+ GP C    +E S  ++  EH G+C +     +C+C 
Sbjct: 382 NEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCL 441

Query: 744 PGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG-WHCVCQVGWSGTGCNVVMEMLC 802
            G+ G  C I      V +     C  +  C LDQ G + C+C  G+ G  C V  +   
Sbjct: 442 QGYTGPRCEI-----DVNECVSNPCQNDATC-LDQIGEFQCICMPGYEGVHCEVNTDECA 495

Query: 803 GDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPD 838
                ++G  L D ++   C+    +   LCQ   D
Sbjct: 496 SSPCLHNGRCL-DKINEFQCECPTGFTGHLCQYDVD 530



 Score =  130 bits (328), Expect = 1e-29
 Identities = 105/361 (29%), Positives = 143/361 (39%), Gaps = 51/361 (14%)

Query: 523  TAIEIMDDCSTNCNGNGEC---ISGH-CHCFPGFLGPDC-----ARDSCPVLCGGN-GEY 572
            T +  +++C++N   +G C   ++G+ C C PG+ G +C       +S P + GG   + 
Sbjct: 712  TCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDM 771

Query: 573  EKGH-CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--E 625
              G+ C CR G+ GP C     +C    C   GTCI  V    C C+  Y G  CE    
Sbjct: 772  TSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLA 831

Query: 626  DCLDPMCSNHGICVKGE------CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG--- 676
             C    C N G C + E      C C TGW G  CE  +  C      HG    +     
Sbjct: 832  PCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGY 891

Query: 677  VCSCDPKWTGSDCSTELCTME---CGSHGVCSRGI----CQCEEGWVGPTCEE--RSCHS 727
             C C   ++G +C T++       C + G C+ GI    C C  G+ G  CEE    C S
Sbjct: 892  RCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECAS 951

Query: 728  H-CTEHGQCKD----GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWH 782
              C     C D      C C  G+ G HC      +   D     CF  G C    N + 
Sbjct: 952  DPCRNGANCTDCVDSYTCTCPAGFSGIHCE-----NNTPDCTESSCFNGGTCVDGINSFT 1006

Query: 783  CVCQVGWSGTGC----NVVMEMLC-GDNLDNDGDGLTDCVDPDCCQQSNCY-ISPLCQGS 836
            C+C  G++G+ C    N      C       DG G   C  P      NC  +   C  S
Sbjct: 1007 CLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSS 1066

Query: 837  P 837
            P
Sbjct: 1067 P 1067



 Score =  130 bits (326), Expect = 2e-29
 Identities = 98/362 (27%), Positives = 130/362 (35%), Gaps = 100/362 (27%)

Query: 528  MDDCSTN-CNGNGECISG----HCHCFPGFLGP-------DCARDSCPVLCGGNGEYEKG 575
            +DDC  N C+  G C  G     C C PGF G        +CA D C          +  
Sbjct: 908  IDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSY 967

Query: 576  HCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE--DCLD 629
             C C  G+ G  C+     C + +CF  GTC+ G+    C+C PG+ G  C+ +  +C  
Sbjct: 968  TCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDS 1027

Query: 630  PMCSNHGICVKG------------------------------------------ECHCST 647
              C + G C  G                                           C C +
Sbjct: 1028 QPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPS 1087

Query: 648  GWGGVNCETPLPVCQ----------EQCSGHGTFLLDAGV---CSCDPKWTGSDCST--- 691
            GW G+ C+ P   C+           +   HG   +DAG    C C   +TGS C     
Sbjct: 1088 GWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVD 1147

Query: 692  ELCTMECGSHGVCSRGI----CQCEEGWVGPTCEER--SCHSH-CTEHGQCKD----GKC 740
            E     C +   C+  +    C+C  G+ G  C E    C SH C   G C D     KC
Sbjct: 1148 ECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKC 1207

Query: 741  ECSPGWEGDHCTIAHYLDAVRDGCPGL--------CFGNGRCTLDQNGWHCVCQVGWSGT 792
             C  G +G HC I      V D  P +        CF NG C     G+ C C  G+ G 
Sbjct: 1208 SCPRGTQGVHCEIN-----VDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE 1262

Query: 793  GC 794
             C
Sbjct: 1263 RC 1264



 Score =  121 bits (303), Expect = 1e-26
 Identities = 98/354 (27%), Positives = 136/354 (38%), Gaps = 75/354 (21%)

Query: 526 EIMDDC-STNCNGNGECISG----HCHCFPGFLGPDCARD--SC---PVLCGGNGEYEKG 575
           E +DDC   NC   G C+ G    +C C P + G  C  D   C   P  C   G     
Sbjct: 256 ENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNT 315

Query: 576 H----CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEEDC 627
           H    CVC +GW G +C    + C    CF   TC   V    C C  G  G +C   D 
Sbjct: 316 HGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDA 375

Query: 628 LDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGS 687
                     C+   C+      G NC+T  PV  +             +C+C   +TG 
Sbjct: 376 ----------CISNPCN-----EGSNCDTN-PVNGK------------AICTCPSGYTGP 407

Query: 688 DCSTEL--CTM---ECGSHGVCSRGI----CQCEEGWVGPTCE-------ERSCHSHCTE 731
            CS ++  C++    C   G C   +    CQC +G+ GP CE          C +  T 
Sbjct: 408 ACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATC 467

Query: 732 HGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCTLDQNGWHCVCQVGWS 790
             Q  + +C C PG+EG HC +        D C    C  NGRC    N + C C  G++
Sbjct: 468 LDQIGEFQCICMPGYEGVHCEVN------TDECASSPCLHNGRCLDKINEFQCECPTGFT 521

Query: 791 GTGCNVVMEMLCGDNLDN-----DGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 839
           G  C   ++        N     DG     CV  +    ++C +  + +  PDP
Sbjct: 522 GHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD-IDECDPDP 574



 Score =  116 bits (290), Expect = 3e-25
 Identities = 96/353 (27%), Positives = 127/353 (35%), Gaps = 100/353 (28%)

Query: 554 GPDCARDSCPVLCGGNGEYEKGH--CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIM--- 608
           GP C++     L GG  E   G   CVC   + GP C  P   C+   C   GTC +   
Sbjct: 21  GPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNP-CLSTPCKNAGTCHVVDR 79

Query: 609 -GV----CICVPGYKGEICE---EEDCLDPMCSNHGIC-----VKGECHCSTGWGGVNCE 655
            GV    C C  G+ G +C    +  CL   C N G C      + +C C  GW G +C+
Sbjct: 80  RGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ 139

Query: 656 TPLPVCQEQCSGHGTFL-LDAG-VCSCDPKWTGSDCSTEL---------------CTMEC 698
              P     C+  G  L  +A  +C C P + G  C  ++               C  E 
Sbjct: 140 QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV 199

Query: 699 GSHGV-----------------CSRGICQ----------------CEEGWVGPTCEER-- 723
           GS+                   CS   CQ                C  G+ G  CEE   
Sbjct: 200 GSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENID 259

Query: 724 SC-HSHCTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGC---PGLCFGNGRCT 775
            C  ++C   G C DG     C C P W G +CT         D C   P  C   G C 
Sbjct: 260 DCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT------EDVDECQLMPNACQNGGTCH 313

Query: 776 LDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCY 828
               G++CVC  GW+G  C+        +N+D       DC    C   + C+
Sbjct: 314 NTHGGYNCVCVNGWTGEDCS--------ENID-------DCASAACFHGATCH 351



 Score =  114 bits (284), Expect = 2e-24
 Identities = 86/310 (27%), Positives = 118/310 (38%), Gaps = 49/310 (15%)

Query: 528 MDDCSTNCNGNGECISG----HCHCFPGFLGPDCARD-----SCPVLCGGNGEYEKGH-- 576
           +D+C  +    G C  G     C C PG+ G  C  +     S P   GG  +       
Sbjct: 567 IDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYL 626

Query: 577 CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDCLDP 630
           C C  G  GP C++  + C    C   GTC+  +    C C PGY G +C    ++C   
Sbjct: 627 CFCLKGTTGPNCEINLDDCASSPC-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGN 685

Query: 631 MCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFL--LDAGVCSCDPKW 684
            C N G C  G     C C  G+    C + +  C      HG     L+   C CDP W
Sbjct: 686 PCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGW 745

Query: 685 TGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERS-----------CHSH-CTEH 732
           +G++C  ++   EC S+   + G C+        TC E             C S+ C   
Sbjct: 746 SGTNC--DINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ 803

Query: 733 GQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRC--TLDQNGWHCVCQ 786
           G C D     KC C   + G  C +      +    P  C   G C  + D   + CVC 
Sbjct: 804 GTCIDDVAGYKCNCLLPYTGATCEV-----VLAPCAPSPCRNGGECRQSEDYESFSCVCP 858

Query: 787 VGWSGTGCNV 796
            GW G  C V
Sbjct: 859 TGWQGQTCEV 868



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 73/302 (24%), Positives = 102/302 (33%), Gaps = 86/302 (28%)

Query: 528  MDDCSTN-CNGNG--ECISG----HCHCFPGFLGPDCAR--DSC---PVLCGGN----GE 571
            +++C +N C+  G   C+      HC C  G  G  C    + C   P   GG       
Sbjct: 1268 VNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASN 1327

Query: 572  YEKGH-CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMG----VCICVPGYKGEICE--- 623
              +G  C C  G++G  C+     C    C   GTCI G     C+C+  + G  C+   
Sbjct: 1328 TARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPA 1387

Query: 624  EEDCL-DPMCSNHGICVKG------ECHCSTGWGGVNC-------------ETPLPVCQE 663
               CL    C N G C          C C   + G+ C             + P P+ +E
Sbjct: 1388 SSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEE 1447

Query: 664  QC--------SGHGTFLLDAGVCSCDPKWTGSDCSTEL---------------------C 694
             C        +G+    L     +C   W G DCS                        C
Sbjct: 1448 ACELPECQEDAGNKVCSLQCNNHACG--WDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHC 1505

Query: 695  TMECGSHGVCSRGI-CQCEEGWVGPT----CEERSCHSHCTEHGQCKDGKCECSPGWEGD 749
              +C S G    G  CQ  EG   P     C++     HC +   C   +CE    W+G 
Sbjct: 1506 DSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQ--GCNSAECE----WDGL 1559

Query: 750  HC 751
             C
Sbjct: 1560 DC 1561



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 54/210 (25%), Positives = 75/210 (35%), Gaps = 52/210 (24%)

Query: 532  STNCNGNGECISGH----CHCFPGFLGPDCARDSCPVLCGGNGEYEKG-----------H 576
            S  C   G CISG     C C   F GP+C   +     GGN  Y +G            
Sbjct: 1354 SLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYR 1413

Query: 577  CVCRHGWKGPEC-------------DVP----EEQCIDPTC---FGHGTCIMGVCICVPG 616
            C+C   + G  C             D+P    EE C  P C    G+  C +       G
Sbjct: 1414 CLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACG 1473

Query: 617  YKGEICEEEDCLDPM--CSNHGICVK----GEC--HCSTG---WGGVNCETPL----PVC 661
            + G  C   +  DP   C+    C K    G C   C++    + G +C+       P+ 
Sbjct: 1474 WDGGDCSL-NFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLY 1532

Query: 662  QEQCSGH-GTFLLDAGVCSCDPKWTGSDCS 690
             + C  H      D G  S + +W G DC+
Sbjct: 1533 DQYCKDHFSDGHCDQGCNSAECEWDGLDCA 1562



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 16/125 (12%)

Query: 729 CTEHGQC--KDGKCECSPGWEGDHCTIAHYLDAVRDGCPGL---CFGNGRC-TLDQNG-- 780
           C++ G+     GKCE + G E   C  A      +D  P L   C   G C  +D+ G  
Sbjct: 24  CSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVA 83

Query: 781 -WHCVCQVGWSGTGCNVVMEMLCGDNLDNDG---DGLT----DCVDPDCCQQSNCYISPL 832
            + C C +G+SG  C   ++  C  N   +G   D LT     C  P      +C  +  
Sbjct: 84  DYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADP 143

Query: 833 CQGSP 837
           C  +P
Sbjct: 144 CASNP 148


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  138 bits (348), Expect = 7e-32
 Identities = 99/363 (27%), Positives = 143/363 (39%), Gaps = 74/363 (20%)

Query: 543 SGHCHCFPGFLGPDCARDSCPVLCGGNGEYEK--GHCVCRHGWKGPECD--VPEEQCIDP 598
           +G+  C  G++GP+C R  C   C       K  G C C++GW+G  CD  +P   C+  
Sbjct: 215 NGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHG 274

Query: 599 TC-----------FG-------------HGTCIMG-----------VCICVPGYKGEICE 623
            C           +G             H  C+ G            C C  GY G  CE
Sbjct: 275 ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334

Query: 624 --EEDCLDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQ-EQCSGHGTF--LLD 674
             E  CL   C N G C +     EC CS GW G  C T +  C    CS  GT   L++
Sbjct: 335 IAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVN 394

Query: 675 AGVCSCDPKWTG-------SDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCE--ERSC 725
              C C P+WTG       ++C  + C        + +   C C  GW+G  C+     C
Sbjct: 395 GFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDC 454

Query: 726 HSHCTEHGQCKD----GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGW 781
              C     C+D     +C C PG+ GDHC        + +     C   G C  + N +
Sbjct: 455 LGQCQNDASCRDLVNGYRCICPPGYAGDHCE-----RDIDECASNPCLNGGHCQNEINRF 509

Query: 782 HCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTD------CVDPDCCQQSNC-YISPLCQ 834
            C+C  G+SG  C + ++  C  N   +G    +      C  P+  +  NC ++   C+
Sbjct: 510 QCLCPTGFSGNLCQLDID-YCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCR 568

Query: 835 GSP 837
            +P
Sbjct: 569 TTP 571



 Score =  125 bits (315), Expect = 4e-28
 Identities = 115/425 (27%), Positives = 155/425 (36%), Gaps = 121/425 (28%)

Query: 528 MDDCS-TNCNGNGEC---ISGH-CHCFPGFLGPDCARDS--CPVLCGGNGEYEKG----- 575
           +DDCS  NC+  G C   ++G  C C P + G  C  D+  C      N +  K      
Sbjct: 375 IDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY 434

Query: 576 HCVCRHGWKGPECDVPEEQCIDPTCFGHGTC---IMGV-CICVPGYKGEICEEE--DCLD 629
           +C C  GW G  CD+    C+   C    +C   + G  CIC PGY G+ CE +  +C  
Sbjct: 435 YCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS 493

Query: 630 PMCSNHGICV----KGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG---VCSCDP 682
             C N G C     + +C C TG+ G  C+  +  C+     +G    +      C C  
Sbjct: 494 NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPE 553

Query: 683 KWTGSDCS-------------TELCTME-----------------CGSHGVCS-----RG 707
            + G +CS              + CT+                  CG HG C      + 
Sbjct: 554 DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKF 613

Query: 708 ICQCEEGWVGPTCEER--SCHSH-CTEHGQCKDG----KCECSPGWEGDHCTI------- 753
            C C +G+ G  C E    C S+ C   G C DG    KC CS GWEG +C         
Sbjct: 614 TCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQ 673

Query: 754 --AHYLDAVRD-----------GCPG-------------LCFGNGRCTLDQNGWHCVCQV 787
              H     RD           G  G              C   G C  + + + C+C  
Sbjct: 674 NPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPG 733

Query: 788 GWSGTGCNVVMEMLC-------GDNLDNDGDGLTDCV------DPDCCQQSN------CY 828
           GW GT CN+     C       G     +G+  T CV       P C Q +N      CY
Sbjct: 734 GWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFT-CVCKEGWEGPICAQNTNDCSPHPCY 792

Query: 829 ISPLC 833
            S  C
Sbjct: 793 NSGTC 797



 Score =  122 bits (305), Expect = 6e-27
 Identities = 106/418 (25%), Positives = 147/418 (35%), Gaps = 117/418 (27%)

Query: 532 STNCNGNGEC----ISGHCHCFPGFLGPDCAR---DSCPVLCGGNG-------------- 570
           S  C+  G C    +   C C PG+ GP C+    D  P  C   G              
Sbjct: 342 SDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCP 401

Query: 571 -------------EYEKGHCV---------------CRHGWKGPECDVPEEQCIDPTCFG 602
                        E E   CV               C  GW G  CD+    C+   C  
Sbjct: 402 PQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLG-QCQN 460

Query: 603 HGTC---IMGV-CICVPGYKGEICEE--EDCLDPMCSNHGICV----KGECHCSTGWGGV 652
             +C   + G  CIC PGY G+ CE   ++C    C N G C     + +C C TG+ G 
Sbjct: 461 DASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520

Query: 653 NCETPLPVCQEQCSGHGTFLLDAG---VCSCDPKWTGSDCS-------------TELCTM 696
            C+  +  C+     +G    +      C C   + G +CS              + CT+
Sbjct: 521 LCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTV 580

Query: 697 E-----------------CGSHGVC-----SRGICQCEEGWVGPTCEE--RSCHSH-CTE 731
                             CG HG C      +  C C +G+ G  C E    C S+ C  
Sbjct: 581 AMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRN 640

Query: 732 HGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQV 787
            G C DG    KC CS GWEG +C        + D     C   G C    N ++C C+ 
Sbjct: 641 GGTCIDGVNSYKCICSDGWEGAYCE-----TNINDCSQNPCHNGGTCRDLVNDFYCDCKN 695

Query: 788 GWSGTGCNVVMEMLCGDNLDNDGDGLTD------CVDPDCCQQSNCYISPLCQGSPDP 839
           GW G  C+   +  C +   N+G    D      C+ P   + + C I+      P+P
Sbjct: 696 GWKGKTCH-SRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNP 752



 Score =  113 bits (283), Expect = 2e-24
 Identities = 73/218 (33%), Positives = 92/218 (42%), Gaps = 35/218 (16%)

Query: 601 FGHGTCIM-GVCICVPGYKGEICEEEDCLDPMCSNHGIC-VKGECHCSTGWGGVNCET-- 656
           FGH  C   G   C+ G+ G  C    C       HG C + G+C C  GW G+ C+   
Sbjct: 207 FGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCI 266

Query: 657 PLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRG--------- 707
           P P C      HG    +   C C+  W G  C  +L    CG+H  C  G         
Sbjct: 267 PHPGCV-----HG-ICNEPWQCLCETNWGGQLCDKDL--NYCGTHQPCLNGGTCSNTGPD 318

Query: 708 --ICQCEEGWVGPTCE--ERSCHSH-CTEHGQCKDG----KCECSPGWEGDHCTIAHYLD 758
              C C EG+ GP CE  E +C S  C   G CK+     +CECSPGW G  C+      
Sbjct: 319 KYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTN---- 374

Query: 759 AVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
            + D  P  C   G C    NG+ CVC   W+G  C +
Sbjct: 375 -IDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQL 411



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 91/324 (28%), Positives = 119/324 (36%), Gaps = 59/324 (18%)

Query: 519 FVLTTAIEIMDDCSTN-CNGNGECISG----HCHCFPGFLGP-------DCARDSCPVLC 566
           F  T   E ++DC +N C   G CI G     C C  G+ G        DC+++ C    
Sbjct: 621 FTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGG 680

Query: 567 GGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCI----MGVCICVPGYKGEIC 622
                    +C C++GWKG  C   + QC + TC   GTC        C+C  G++G  C
Sbjct: 681 TCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC 740

Query: 623 ---EEEDCLDPMCSNHGIC-VKGE---CHCSTGWGGVNCETPLPVCQE---QCSGHGTFL 672
                  CL   C N G C V GE   C C  GW G       P+C +    CS H  + 
Sbjct: 741 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEG-------PICAQNTNDCSPHPCYN 793

Query: 673 LDAGV-------CSCDPKWTGSDCS---TELCTMECGSHGVCSRGI----CQCEEGWVGP 718
               V       C C P + G DC     E  +  C     C   I    C C  G  G 
Sbjct: 794 SGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGA 853

Query: 719 TCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQ 778
            C+E S     T      DG       W+ D C     L+  R  C  +  G   C L +
Sbjct: 854 KCQEVSGRPCITMGSVIPDG-----AKWD-DDCNTCQCLNG-RIACSKVWCGPRPCLLHK 906

Query: 779 NGWHCVCQVGWSGTGCNVVMEMLC 802
               C      SG  C  +++  C
Sbjct: 907 GHSECP-----SGQSCIPILDDQC 925



 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 55/212 (25%), Positives = 76/212 (35%), Gaps = 30/212 (14%)

Query: 645 CSTGWGGVNCETPLPVCQEQCSGHGTFLLDA-GVCSCDPKWTGSDCSTELCTMECG-SHG 702
           C   + G  C      C+ +    G +  D  G  +C   W G +C+  +C   C   HG
Sbjct: 187 CDDYYYGFGCNK---FCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHG 243

Query: 703 VCSR-GICQCEEGWVGPTCEERSCHSHCTEHGQCKD-GKCECSPGWEGDHCTIAHYLDAV 760
            C   G C+C+ GW G  C++   H  C  HG C +  +C C   W G  C      D  
Sbjct: 244 SCKLPGDCRCQYGWQGLYCDKCIPHPGCV-HGICNEPWQCLCETNWGGQLCD----KDLN 298

Query: 761 RDGCPGLCFGNGRCT-LDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGD-------- 811
             G    C   G C+    + + C C  G+SG  C +       D   N G         
Sbjct: 299 YCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGF 358

Query: 812 ---------GLTDCVDPDCCQQSNCYISPLCQ 834
                    G T   + D C  +NC     CQ
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQ 390


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  137 bits (344), Expect = 2e-31
 Identities = 107/339 (31%), Positives = 127/339 (37%), Gaps = 79/339 (23%)

Query: 531 CSTNCNGNGECISGH-CHCFPGFLGPDCA------------RDSCPVLCGGNGEYEKGHC 577
           C+  C  +G C+S   CHC PG+ GPDC+             + C    G       G C
Sbjct: 103 CTEECV-HGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGAC 161

Query: 578 VCRHGWKGPECDVPEEQCIDPT----------CFGHGTC--IMGVCICVPGYKGEICEE- 624
           VC  G++G  C   EE C   T          C    +C    G C+C PGY G  CEE 
Sbjct: 162 VCAAGFRGWRC---EELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEEL 218

Query: 625 -------EDC-LDPMCSNHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQCSGH 668
                    C L   C N G C  + GEC C  GW G  C  P P       C + C  H
Sbjct: 219 CPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCH 278

Query: 669 GTFLLD--AGVCSCDPKWTGSDCSTEL--------CTMECGSH--GVCS--RGICQCEEG 714
                D   G C C   + G  C  E         C+  C  H  G CS   G C+CE G
Sbjct: 279 HGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPG 338

Query: 715 WVGPTCEERSCHS-----HCTEHGQCK----------DGKCECSPGWEGDHCTIAHYLDA 759
           + GP C+ER C        CT    C            G C C PGW G HC  +  +  
Sbjct: 339 YKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGY 398

Query: 760 VRDGC--PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
             DGC  P  C     C     G  C C  G+ G  C V
Sbjct: 399 YGDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAV 435



 Score =  135 bits (341), Expect = 4e-31
 Identities = 115/429 (26%), Positives = 154/429 (35%), Gaps = 146/429 (34%)

Query: 535 CNGNGEC--ISGHCHCFPGFLGPDCARD--------SCPVLC----GGNGEYEKGHCVCR 580
           C    +C  I+G C C PGF+G  CA          +C  +C    GG      G C C+
Sbjct: 409 CQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCK 468

Query: 581 HGWKGPECDVP----------EEQCIDPTCFGHGTC--IMGVCICVPGYKGEICE---EE 625
            GW+G +C +P           E C   TC     C  I G C C PG+ G+ CE    +
Sbjct: 469 EGWQGLDCTLPCPSGTWGLNCNESC---TCANGAACSPIDGSCSCTPGWLGDTCELPCPD 525

Query: 626 DCLDPMCSNHGIC--------VKGECHCSTGWGGVNCETPLP------------------ 659
                 CS H  C        V G C C  GW G+ C++  P                  
Sbjct: 526 GTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGG 585

Query: 660 ------------------VCQEQCS----GHGTFLLD-------------AGVCSCDPKW 684
                             +CQ  C     GHG                  +G+C C P +
Sbjct: 586 SCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGF 645

Query: 685 TGSDCS------------TELCTMECGSHGVCSR--GICQCEEGWVGPTCEER------- 723
           +G+ C+             +LC+  C ++G CS   G CQC  GW+G  C +        
Sbjct: 646 SGALCNQVCAGGYFGQDCAQLCS--CANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWG 703

Query: 724 -SCHSHCTEHG----QCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGN--GRCTL 776
            +C   C+ H       +DG C C+PGW G  CT           CP   FG   GR   
Sbjct: 704 PACFHACSCHNGASCSAEDGACHCTPGWTGLFCT---------QRCPAAFFGKDCGRVCQ 754

Query: 777 DQNG-------WHCVCQVGWSGTGCNVVMEMLCGDNLDNDG-DGLTDCVDPDCCQQ--SN 826
            QNG         C C+ G++G  C    E  C       G   L +C++   C      
Sbjct: 755 CQNGASCDHISGKCTCRTGFTGQHC----EQRCAPGTFGYGCQQLCECMNNSTCDHVTGT 810

Query: 827 CYISPLCQG 835
           CY SP  +G
Sbjct: 811 CYCSPGFKG 819



 Score =  125 bits (314), Expect = 6e-28
 Identities = 92/323 (28%), Positives = 124/323 (38%), Gaps = 79/323 (24%)

Query: 534 NCNGNGEC--------ISGHCHCF-------------PGFLGPDCARDSCPVLCGGNGEY 572
           NC+ + +C        ++GHC C              PG  GP+C+  SC    GG+   
Sbjct: 531 NCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCS-VSCSCENGGSCSP 589

Query: 573 EKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC---------------IMGVCICVPGY 617
           E G C C  G++GP C    ++   P  +GHG                 I G+C C+PG+
Sbjct: 590 EDGSCECAPGFRGPLC----QRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGF 645

Query: 618 KGEICEE--------EDCLD-PMCSNHGIC--VKGECHCSTGWGGVNCETPL------PV 660
            G +C +        +DC     C+N+G C  + G C C  GW G +C          P 
Sbjct: 646 SGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPA 705

Query: 661 CQEQCSGHGTFLLDA--GVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGP 718
           C   CS H      A  G C C P WTG  C+        G    C R +CQC+    G 
Sbjct: 706 CFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKD--CGR-VCQCQN---GA 759

Query: 719 TCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQ 778
           +C+  S             GKC C  G+ G HC           GC  LC      T D 
Sbjct: 760 SCDHIS-------------GKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDH 806

Query: 779 NGWHCVCQVGWSGTGCNVVMEML 801
               C C  G+ G  C+    M+
Sbjct: 807 VTGTCYCSPGFKGIRCDQAALMM 829



 Score =  124 bits (310), Expect = 2e-27
 Identities = 95/318 (29%), Positives = 123/318 (38%), Gaps = 80/318 (25%)

Query: 530 DCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECD 589
           DC  +  G  + ++G CHC  G++G  C ++ CP   G  G     HC C +G       
Sbjct: 274 DCPCHHGGQCDHVTGQCHCTAGYMGDRC-QEECPF--GSFGFQCSQHCDCHNG------- 323

Query: 590 VPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLD----PMCSNHGIC------- 638
               QC   T         G C C PGYKG  C+E  C +    P C+    C       
Sbjct: 324 ---GQCSPTT---------GACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTIS 371

Query: 639 ---VKGECHCSTGWGGVNCETPLPV------CQEQC---SGHGTFLLDAGVCSCDPKWTG 686
              V G C C  GW G +C    PV      CQ  C   +G     +  G C+C P + G
Sbjct: 372 CHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG-CTCAPGFMG 430

Query: 687 SDCSTELCT----------MECGSHGVCS--RGICQCEEGWVGPTCE--------ERSCH 726
             C+                 C + G CS   G C C+EGW G  C           +C+
Sbjct: 431 EVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCN 490

Query: 727 SHCT--EHGQCK--DGKCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCT----LD 777
             CT      C   DG C C+PGW GD C +        DG  GL C  +  C+     D
Sbjct: 491 ESCTCANGAACSPIDGSCSCTPGWLGDTCEL-----PCPDGTFGLNCSEHCDCSHADGCD 545

Query: 778 QNGWHCVCQVGWSGTGCN 795
               HC C  GW+G  C+
Sbjct: 546 PVTGHCCCLAGWTGIRCD 563



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 67/225 (29%), Positives = 84/225 (37%), Gaps = 54/225 (24%)

Query: 613 CVPGYKGEICEEEDCLDPMCSN---HGICVKGE-CHCSTGWGGVNCETPL------PVCQ 662
           C PGY     E  D   P+C+    HG CV  + CHC  GWGG +C +        P C 
Sbjct: 88  CCPGYY----ESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCS 143

Query: 663 EQCSGHGTFLLD--AGVCSCDPKWTGSDCSTELCTMECGSHG-------VCSRGI----- 708
            +C      L +   G C C   + G  C  ELC    G+HG        C  G      
Sbjct: 144 NRCQCQNGALCNPITGACVCAAGFRGWRCE-ELCAP--GTHGKGCQLPCQCRHGASCDPR 200

Query: 709 ---CQCEEGWVGPTCEE----RSCHSHCTEHGQCKD--------GKCECSPGWEG----D 749
              C C  G+ G  CEE     S  +HC     C++        G+C C PGW G     
Sbjct: 201 AGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQ 260

Query: 750 HCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
            C    +       CP  C   G+C  D     C C  G+ G  C
Sbjct: 261 PCPPGTFGQNCSQDCP--CHHGGQC--DHVTGQCHCTAGYMGDRC 301



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 56/193 (29%), Positives = 74/193 (38%), Gaps = 49/193 (25%)

Query: 530 DCST--NCNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKG 585
           DC+   +C  NG C  I G C CFPG++G DC++                   C  G+ G
Sbjct: 662 DCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQ------------------ACPPGFWG 703

Query: 586 PECDVPEEQCIDPTCFGHGTCIM--GVCICVPGYKGEICEE--------EDCLDP-MCSN 634
           P C      C   +C    +C    G C C PG+ G  C +        +DC     C N
Sbjct: 704 PACF---HAC---SCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQN 757

Query: 635 HGIC--VKGECHCSTGWGGVNCETPLPV------CQEQCSGHGTFLLD--AGVCSCDPKW 684
              C  + G+C C TG+ G +CE           CQ+ C        D   G C C P +
Sbjct: 758 GASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGF 817

Query: 685 TGSDCSTELCTME 697
            G  C      ME
Sbjct: 818 KGIRCDQAALMME 830



 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 43/137 (31%), Positives = 53/137 (38%), Gaps = 20/137 (14%)

Query: 680 CDPKWTGSDCSTELCTMECGSHGVC-SRGICQCEEGWVGPTCEERSCHS-----HCTEHG 733
           C   +   D    LCT EC  HG C S   C CE GW GP C    C S     HC+   
Sbjct: 89  CPGYYESGDFCIPLCTEEC-VHGRCVSPDTCHCEPGWGGPDCSS-GCDSDHWGPHCSNRC 146

Query: 734 QCKD--------GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVC 785
           QC++        G C C+ G+ G  C           GC   C      + D     C+C
Sbjct: 147 QCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLC 206

Query: 786 QVGWSGTGCNVVMEMLC 802
             G++G  C    E LC
Sbjct: 207 APGYTGVYC----EELC 219


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  135 bits (340), Expect = 6e-31
 Identities = 95/309 (30%), Positives = 124/309 (40%), Gaps = 44/309 (14%)

Query: 525 IEIMDDCSTNCNGNGECISG----HCHCFPGFLGPDCARDSCPVL---CGGNGEYEKG-- 575
           +EI +  S+ C   G C+ G     C C PG L P C   S P     C     Y+    
Sbjct: 656 VEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG 715

Query: 576 -HCVCRHGWKGPEC--DVPEEQCIDPTCFGHGTCI---MGV-CICVPGYKGEICE-EEDC 627
             CVC  GW GP C   +  + C    C   GTC    MG  C C PG +G  CE    C
Sbjct: 716 FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC 775

Query: 628 LDPMCSNHGICVKGE-----CHCSTGWGGVNCETPLPVC--QEQCSGHG--TFLLDAGVC 678
               C + G C         C C  GW G  C+  +  C     C  HG  T L  +  C
Sbjct: 776 TPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835

Query: 679 SCDPKWTGSDCSTELCTME---CGSHGVCSRGI----CQCEEGWVGPTC--EERSCHSHC 729
           +C   +TG  C  ++   +   C + G C  G+    C C  G+ GP C  +   C S+ 
Sbjct: 836 TCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895

Query: 730 TEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVC 785
              G C D      C C PG+ G HC        + D  P  CF  G C    N + C+C
Sbjct: 896 CGPGTCTDHVASFTCTCPPGYGGFHCE-----QDLPDCSPSSCFNGGTCVDGVNSFSCLC 950

Query: 786 QVGWSGTGC 794
           + G++G  C
Sbjct: 951 RPGYTGAHC 959



 Score =  134 bits (338), Expect = 9e-31
 Identities = 115/419 (27%), Positives = 147/419 (35%), Gaps = 108/419 (25%)

Query: 528  MDDCSTN-CNGNGECISG----HCHCFPGFLGPDCARDSCPVL---CGGN---GEYEKGH 576
            ++DC  N C   G C  G     C C PGF GP CARD    L   CG            
Sbjct: 850  INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFT 909

Query: 577  CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE--DCLDP 630
            C C  G+ G  C+     C   +CF  GTC+ GV    C+C PGY G  C+ E   CL  
Sbjct: 910  CTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSR 969

Query: 631  MCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQ-CSGHGTFLLDAGVCSCDPKWT 685
             C + G+C        C C   + G  C+T +  C  Q C   G  +     C C P W+
Sbjct: 970  PCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWS 1029

Query: 686  GSDCSTELCTME-------------CGSHGVC----SRGICQCEEGWVGPTCEER--SCH 726
            G  C                     C + G C    S   C C EG  G  CE+    C 
Sbjct: 1030 GRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCL 1089

Query: 727  SHCTEHGQCKDG-----KCECSPGWEGDHC--------------------TIAHYLDAVR 761
            +   +HG    G      CEC PG+ GD+C                     +A YL +  
Sbjct: 1090 AQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCP 1149

Query: 762  DGCPGL--------------------CFGNGRCTLDQNGWHCVCQVGWSGTGCNV-VMEM 800
             G  G+                    C  NG C     G+ C C  G++G  C   + E 
Sbjct: 1150 PGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC 1209

Query: 801  LCG--------DNLDNDGDGLTDCV------DPDC------CQQSNCYISPLCQGSPDP 839
              G        D L + G G   C+       P C      C+   C     C+ SP P
Sbjct: 1210 RSGACHAAHTRDCLQDPGGGFR-CLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGP 1267



 Score =  132 bits (333), Expect = 4e-30
 Identities = 104/363 (28%), Positives = 141/363 (38%), Gaps = 67/363 (18%)

Query: 531 CSTNCNGNGECISGHCH---------------CFPGFLGPDCARD-----SCPVLCGG-- 568
           C T+ N   EC+SG C                C  GF G  C  D     S P + GG  
Sbjct: 428 CETDVN---ECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC 484

Query: 569 NGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE 624
                   C C  G+ G  C +  ++C    C     C+       C C  G++G +C+ 
Sbjct: 485 KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544

Query: 625 --EDCLDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHG---TFLLDA 675
             +DC    C +HG CV G     C C+ G+ G  CE+ +  C+ Q   HG     L+D 
Sbjct: 545 NVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK 603

Query: 676 GVCSCDPKWTGSDCSTEL--CTMECGSHGVCSRGI----CQCEEGWVGPTC--EERSC-H 726
            +C C    TG +C   +  C     + GVC  GI    C C+ G+ GP C  E   C  
Sbjct: 604 YLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECAS 663

Query: 727 SHCTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWH 782
           S C E G C DG    +C C PG     C    +  A      G+C+          G+ 
Sbjct: 664 SPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYD------APGGFR 717

Query: 783 CVCQVGWSGTGCNVVM--------EMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
           CVC+ GWSG  C+  +            G    +DG G   C  P   Q   C +   C 
Sbjct: 718 CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGF-HCTCPPGVQGRQCELLSPCT 776

Query: 835 GSP 837
            +P
Sbjct: 777 PNP 779



 Score =  126 bits (317), Expect = 3e-28
 Identities = 103/350 (29%), Positives = 133/350 (38%), Gaps = 45/350 (12%)

Query: 528 MDDCSTNCNGNGECISG----HCHCFPGFLGPDCAR--DSC---PVLCGGN--GEYEKGH 576
           +DDCS +   +G C+ G     C C PG+ G  C    D C   P   GG      +K  
Sbjct: 546 VDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605

Query: 577 CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE--DCLDP 630
           C C  G  G  C+V  + C    C   G C  G+    C+C PG+ G +C  E  +C   
Sbjct: 606 CRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASS 664

Query: 631 MCSNHGICVKGE----CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG--VCSCDPKW 684
            C   G CV GE    C C  G     C  P   C  +   HG      G   C C+P W
Sbjct: 665 PCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGW 724

Query: 685 TGSDCSTELC-----TMECGSHGVCSRG----ICQCEEGWVGPTCEERS-CHSHCTEH-G 733
           +G  CS  L      +  C + G CS       C C  G  G  CE  S C  +  EH G
Sbjct: 725 SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGG 784

Query: 734 QCKDGK-----CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVG 788
           +C+        C C  GW+G  C      D      P  C  +G CT     + C C  G
Sbjct: 785 RCESAPGQLPVCSCPQGWQGPRC----QQDVDECAGPAPCGPHGICTNLAGSFSCTCHGG 840

Query: 789 WSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPD 838
           ++G  C+  +   C  N   +G    D V    C     +  P C    D
Sbjct: 841 YTGPSCDQDIND-CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVD 889



 Score =  120 bits (301), Expect = 2e-26
 Identities = 107/394 (27%), Positives = 139/394 (35%), Gaps = 93/394 (23%)

Query: 528 MDDC-STNCNGNGECIS----GHCHCFPGFLG-------PDCARDSCP--VLCGGNGEYE 573
           +D+C S  C   G+C+       C C  G  G        DCA + C   V   G   Y+
Sbjct: 583 VDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYD 642

Query: 574 KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEIC--EEEDC 627
              CVC+ G+ GP C+V   +C    C   G+C+ G     C+C PG    +C      C
Sbjct: 643 ---CVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC 699

Query: 628 LDPMCSNHGICVKG----ECHCSTGWGGVNCETPL--PVCQEQ-CSGHGTFLLDA----- 675
               CS HGIC        C C  GW G  C   L    C+ Q C   GT   D      
Sbjct: 700 AHEPCS-HGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHC 758

Query: 676 -----------------------------------GVCSCDPKWTGSDCSTEL--CT--M 696
                                               VCSC   W G  C  ++  C    
Sbjct: 759 TCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPA 818

Query: 697 ECGSHGVCSR----GICQCEEGWVGPTCEE--RSCHSH-CTEHGQCKDG----KCECSPG 745
            CG HG+C+       C C  G+ GP+C++    C  + C   G C+DG     C C PG
Sbjct: 819 PCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPG 878

Query: 746 WEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDN 805
           + G  C          D C     G G CT     + C C  G+ G  C   +   C  +
Sbjct: 879 FAGPRCA------RDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPD-CSPS 931

Query: 806 LDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDP 839
              +G    D V+   C     Y    CQ   DP
Sbjct: 932 SCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965



 Score =  118 bits (296), Expect = 7e-26
 Identities = 101/375 (26%), Positives = 147/375 (39%), Gaps = 70/375 (18%)

Query: 528 MDDCSTN--CNGNGECI----SGHCHCFPGFLGPDCARDSCPVL---CGGNGEYEKG--- 575
           +D+C     C   G C+    S  C C  G+ GP C   + P     C   G   +    
Sbjct: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDL 218

Query: 576 --HCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDC 627
              C C  G++G  C+V  + C    C   GTC+ GV    C C P + G+ C E  ++C
Sbjct: 219 TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278

Query: 628 -LDP-MCSNHGICVK----GECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLD---AGVC 678
            L P  C N G C        C C  GW G +C   +  C      HG    D   +  C
Sbjct: 279 QLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYC 338

Query: 679 SCDPKWTGSDCSTELCTME--------CGSHGVCSRGICQCEEGWVGPTC----EERSCH 726
           +C    TG  C  +   +         C ++ V  R IC C  G+ G  C    +E S  
Sbjct: 339 ACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIG 398

Query: 727 SHCTEH-GQCKDGK----CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG- 780
           ++  EH G+C + +    C+C  G+ G  C        V +   G C     C LD+ G 
Sbjct: 399 ANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE-----TDVNECLSGPCRNQATC-LDRIGQ 452

Query: 781 WHCVCQVGWSGTGCNVVMEM----------LCGDNLD-------NDGDGLTDCVDPDCCQ 823
           + C+C  G++GT C V ++           +C D ++       +   G T  +D D C 
Sbjct: 453 FTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECA 512

Query: 824 QSNCYISPLCQGSPD 838
            + C     C   PD
Sbjct: 513 STPCRNGAKCVDQPD 527



 Score =  115 bits (289), Expect = 5e-25
 Identities = 88/352 (25%), Positives = 131/352 (37%), Gaps = 79/352 (22%)

Query: 535 CNGNGECIS-----GHCHCFPGFLGPDCA-RDSCPV-LCGGNGEYEKG--------HCVC 579
           C   G C         C C PG++G  C   D C    C G G  +           C C
Sbjct: 49  CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108

Query: 580 RHGWKGPECDVPEEQCIDPTCFGHGTCIMG-----VCICVPGYKGEIC--EEEDC-LDPM 631
             G++GP+C +P + C+   C     C +G     +C C PGY+G  C  + ++C +   
Sbjct: 109 PRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167

Query: 632 CSNHGICVKG----ECHCSTGWGGVNCETP-LPVCQEQCSGHGTFLLDAGV---CSCDPK 683
           C + G C+       C C  G+ G  CE P +P     C   GT      +   C+C P 
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPG 227

Query: 684 WTGSDCSTELCTMECGSH-----GVCSRGI----CQCEEGWVGPTCEE---------RSC 725
           + G +C  E+   +C  H     G C  G+    CQC   W G  C E          +C
Sbjct: 228 FEGQNC--EVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNAC 285

Query: 726 HSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVC 785
           H+  T         C C  GW G+ C+       + D    +CF    C      ++C C
Sbjct: 286 HNGGTCFNTLGGHSCVCVNGWTGESCS-----QNIDDCATAVCFHGATCHDRVASFYCAC 340

Query: 786 QVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSP 837
            +G +G  C++                       D C  + C+   +C  +P
Sbjct: 341 PMGKTGLLCHL----------------------DDACVSNPCHEDAICDTNP 370



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 105/414 (25%), Positives = 141/414 (34%), Gaps = 125/414 (30%)

Query: 528  MDDCSTN-CNGNGEC---ISGH-CHCFPGFLGPDCARD-----SCPVLCGGN--GEYEKG 575
            +D C    C   G C   + G+ C C PG+ G +C  D     S P   GG+      + 
Sbjct: 1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARY 1144

Query: 576  HCVCRHGWKGPECDVPEEQC-------IDPTCFGHGTCIMGV----CICVPGYKGEICEE 624
             C C  G  G  C++ E+ C         P C  +GTC+  V    C C PGY G  CE 
Sbjct: 1145 LCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEA 1204

Query: 625  E--DCLDPMC--SNHGICVKG-----ECHCSTGWGGVNCETPLPVCQEQCSGHG------ 669
            +  +C    C  ++   C++       C C  G+ G  C+T L  C+ Q   HG      
Sbjct: 1205 DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPS 1264

Query: 670  -------TFLLDA-----------------------GV----------CSCDPKWTGSDC 689
                   TF                           GV          C+C P  +G  C
Sbjct: 1265 PGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324

Query: 690  ----------STELCTMECGSHGVCSRGI-------CQCEEGWVGPTCEERSCHSHCTEH 732
                      S   C      HG   R         C C +GW GP CE  +     +E 
Sbjct: 1325 RSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEE 1384

Query: 733  GQCKDGKC-----------ECSP---GWEGDHCTIAHYLDAVRDGCPGL----CFGNGRC 774
             +C    C           EC+    GW+G  C+++   D  R  C  L     F N RC
Sbjct: 1385 PRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS-VGDPWRQ-CEALQCWRLFNNSRC 1442

Query: 775  TLDQNGWHCV-----CQVGWSGTGCNVVMEMLCGDNLDNDGDGLTD--CVDPDC 821
                +   C+     C  G     CN V E  C D+     DG  D  C   +C
Sbjct: 1443 DPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHF---ADGRCDQGCNTEEC 1493



 Score = 40.4 bits (93), Expect = 0.024
 Identities = 34/135 (25%), Positives = 44/135 (32%), Gaps = 42/135 (31%)

Query: 714 GWVGPTCEERSCHSHCTEHGQC-----KDGKCECSPGWEGDHCTIAHYLDAVRDGC-PGL 767
           G   P C + S    C   G+C     ++  C C PGW G+ C +        D C  G 
Sbjct: 37  GAAAPPCLDGS---PCANGGRCTQLPSREAACLCPPGWVGERCQL-------EDPCHSGP 86

Query: 768 CFGNGRC----TLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQ 823
           C G G C          + C C  G+ G  C++                      PD C 
Sbjct: 87  CAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSL----------------------PDPCL 124

Query: 824 QSNCYISPLCQGSPD 838
            S C     C   PD
Sbjct: 125 SSPCAHGARCSVGPD 139



 Score = 36.2 bits (82), Expect = 0.45
 Identities = 44/197 (22%), Positives = 56/197 (28%), Gaps = 87/197 (44%)

Query: 546  CHCFPGFLGPDC----------ARDSC---PVLCGGNGEYEK----GHCVCRHGWKGPEC 588
            C C PG  GP C          +  SC   P L GG+           C C  GW GP C
Sbjct: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372

Query: 589  DVP--------------------------EEQCIDPTCFGHGTCIMGVCICVPGYKGEIC 622
            + P                          + +C  P C   G    G C    G     C
Sbjct: 1373 EAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDG----GDCSLSVGDPWRQC 1428

Query: 623  EEEDC--------LDPMCSNHGICVKG-ECH----------------------------C 645
            E   C         DP CS+        +CH                            C
Sbjct: 1429 EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGC 1488

Query: 646  ST---GWGGVNCETPLP 659
            +T   GW G++C + +P
Sbjct: 1489 NTEECGWDGLDCASEVP 1505


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  135 bits (339), Expect = 7e-31
 Identities = 95/339 (28%), Positives = 132/339 (38%), Gaps = 57/339 (16%)

Query: 525 IEIMDDCSTNCNGNGEC---ISG-HCHCFPGFLGPDCARD-----SCPVLCGGNGEYEKG 575
           +E  +  S  C  + +C   ++G  C C PGF G  C  D     S P   GG  + + G
Sbjct: 512 VETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPG 571

Query: 576 --HCVCRHGWKGPECDVPEEQCIDPTCFGHGTCI----MGVCICVPGYKGEICEEEDCLD 629
             HC C  G++GP C    ++C+   C    +C+       C+C  G+ G++CE   C  
Sbjct: 572 AFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAP 631

Query: 630 PMCSNHGIC--VKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGS 687
            +C    IC   K + +C    G   C  P    ++ C+ H         C CD  WTG 
Sbjct: 632 NLCQPKQICKDQKDKANCLCPDGSPGCAPP----EDNCTCHHGH-CQRSSCVCDVGWTGP 686

Query: 688 DCSTEL---CTMECGSHGVC----SRGICQCEEGWVGPTCEER--SCHS-HCTEHGQCKD 737
           +C  EL    +  C   G C    S   C C  G+ GPTC E   +CHS  C   G C  
Sbjct: 687 ECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNP 746

Query: 738 GK----CECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCTLDQNGWHCVCQVGWSGT 792
                 C C P   G  C  +       D C    CF  G C      + C+C +G+ G 
Sbjct: 747 SPGGYYCTCPPSHTGPQCQTS------TDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGP 800

Query: 793 GCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISP 831
            C              +G     C D  C  ++ C  SP
Sbjct: 801 RC--------------EGKLRPSCADSPCRNRATCQDSP 825



 Score =  135 bits (339), Expect = 7e-31
 Identities = 95/339 (28%), Positives = 138/339 (40%), Gaps = 69/339 (20%)

Query: 532  STNCNGNGECI---SGH-CHCFPGFLGPDCARD-----SCPVLCGGNGEYEKG--HCVCR 580
            S  C   G C    SG+ C C  G+ GP C+ +     S P L GG+     G  +C C 
Sbjct: 697  SAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCP 756

Query: 581  HGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEE---DCLDPMCS 633
                GP+C    + C+   CF  GTC+       C+C  G++G  CE +    C D  C 
Sbjct: 757  PSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCR 816

Query: 634  NHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGV---CSCDPKWTG 686
            N   C        C C TG+ G +C+T + +C ++     +  L  G    C C   WTG
Sbjct: 817  NRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTG 876

Query: 687  SDCSTELCTME-------------CGSHGVCSRG----ICQCEEGWVGPTC-------EE 722
              C+  L + +             C + G+C        C C  G+ G  C       E 
Sbjct: 877  PLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCES 936

Query: 723  RSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWH 782
            R C +  T   Q     C+C+PG++G +C  +  LDA +      C  +G CT    G+H
Sbjct: 937  RPCQNGATCMAQPSGYLCQCAPGYDGQNC--SKELDACQS---QPCHNHGTCTPKPGGFH 991

Query: 783  CVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDC 821
            C C  G+ G  C              +GD + +C+D  C
Sbjct: 992  CACPPGFVGLRC--------------EGD-VDECLDQPC 1015



 Score =  127 bits (319), Expect = 2e-28
 Identities = 107/358 (29%), Positives = 132/358 (36%), Gaps = 87/358 (24%)

Query: 535 CNGNGECIS-----GHCHCFPGFLGPDCA-RDSC--PVLCGGNGEYE------------- 573
           C   G C+S     G C C PGFLG  C   D C    LC   G  +             
Sbjct: 35  CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSP 94

Query: 574 -----KGHCVCRHGWKGPECDVP-EEQCIDPTCFGHGTCIMGV-----CICVPGYKGEIC 622
                   C C  G+ G  C    E+ C    C   G C +       C C+PG+ GE C
Sbjct: 95  SPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQC 154

Query: 623 EEED-CLDPMCSNHGICV----KGECHCSTGWGGVNCE--------TPLPVCQEQCSGHG 669
           +  D C    C N G+C+    + +CHC  G+ G  CE         P P C +  S H 
Sbjct: 155 QLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGP-CPKGTSCHN 213

Query: 670 TFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQ-------------CEEGWV 716
           T  L +  C C     G  C  EL    C   G  + G CQ             C  G++
Sbjct: 214 T--LGSFQCLCPVGQEGPRC--ELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFI 269

Query: 717 GPTCEER--SCHSH-CTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCF 769
           GP CE    +C SH C   G C+DG     C C   W G  C  +  +D      P  C 
Sbjct: 270 GPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDC--SEDVDECETQGPPHCR 327

Query: 770 GNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
             G C      +HCVC  GW GT C         +NLD       DC+   C   S C
Sbjct: 328 NGGTCQNSAGSFHCVCVSGWGGTSCE--------ENLD-------DCIAATCAPGSTC 370



 Score =  120 bits (302), Expect = 1e-26
 Identities = 117/406 (28%), Positives = 149/406 (36%), Gaps = 113/406 (27%)

Query: 529 DDC-STNCNGNGECISG----HCHCFPGFLGPDCARD--SC----PVLCGGNGEYEKG-- 575
           D+C S  C   G C  G     C C   + G DC+ D   C    P  C   G  +    
Sbjct: 278 DNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAG 337

Query: 576 --HCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEED-CL 628
             HCVC  GW G  C+   + CI  TC    TCI  V    C+C PG  G +C  ED CL
Sbjct: 338 SFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCL 397

Query: 629 ------DPMCSNHGICVKGECHCSTGWGGVNCETPLPVC------QEQCSGHGTFLLDAG 676
                 D  CS + +     C C  G+ G  C   L  C         C   G+ L   G
Sbjct: 398 SQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPG 457

Query: 677 V--CSCDPKWTGSDCSTE------------------------LC------------TMEC 698
              C C P +TGS C  +                        LC            T EC
Sbjct: 458 SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC 517

Query: 699 GS---------HGVCSRGICQCEEGWVGPTCEE--RSCHSH-CTEHGQCKDG----KCEC 742
            S         H + +   C C  G+ G  CEE    C S  C   GQC+D      C+C
Sbjct: 518 ASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKC 577

Query: 743 SPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG-WHCVCQVGWSGTGCNVVM--- 798
            PG+EG  C      + + D CP      G   LD  G + C+C  G++G  C V +   
Sbjct: 578 LPGFEGPRCQ-TEVDECLSDPCP-----VGASCLDLPGAFFCLCPSGFTGQLCEVPLCAP 631

Query: 799 -----EMLCGDNLDNDG----DGLTDCVDPD--C------CQQSNC 827
                + +C D  D       DG   C  P+  C      CQ+S+C
Sbjct: 632 NLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSC 677



 Score =  120 bits (300), Expect = 2e-26
 Identities = 86/318 (27%), Positives = 119/318 (37%), Gaps = 49/318 (15%)

Query: 526 EIMDDCSTN-CNGNGECISGH----CHCFPGFLGPDCARD---------SCPVLCGGNGE 571
           ++ D CS N C   G C++ +    CHC PGF G  C RD          CP     +  
Sbjct: 155 QLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNT 214

Query: 572 YEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC--------IMGVCICVPGYKGEICE 623
                C+C  G +GP C++    C    C   GTC           +C+C PG+ G  CE
Sbjct: 215 LGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCE 274

Query: 624 --EEDCLDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQ----CSGHGTFLL 673
              ++C+   C N G C  G     C C   W G +C   +  C+ Q    C   GT   
Sbjct: 275 VNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQN 334

Query: 674 DAGV--CSCDPKWTGSDCSTEL---CTMECGSHGVCSRGI----CQCEEGWVGPTCE--- 721
            AG   C C   W G+ C   L       C     C   +    C C  G  G  C    
Sbjct: 335 SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLED 394

Query: 722 ---ERSCH--SHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTL 776
               + CH  + C+ +       C C PG+ G  C        +    P  C   G C  
Sbjct: 395 MCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLN 454

Query: 777 DQNGWHCVCQVGWSGTGC 794
               ++C+C  G++G+ C
Sbjct: 455 TPGSFNCLCPPGYTGSRC 472



 Score =  106 bits (265), Expect = 3e-22
 Identities = 92/316 (29%), Positives = 118/316 (37%), Gaps = 62/316 (19%)

Query: 545 HCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHG 604
           +C C  G   P CA       C  +G  ++  CVC  GW GPEC+     CI   C   G
Sbjct: 648 NCLCPDG--SPGCAPPEDNCTCH-HGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGG 704

Query: 605 TCIMGV----CICVPGYKGEICEEEDCLDPMCSNH-GICVKGECHCSTGWGGVNCETPLP 659
           TC        C C  GY G  C EE     M + H G C+ G   C+   GG        
Sbjct: 705 TCYPQPSGYNCTCPTGYTGPTCSEE-----MTACHSGPCLNGG-SCNPSPGGY------- 751

Query: 660 VCQEQCSGHGTFLLDAGVCSCDPKWTGSDC--STELC-TMECGSHGVC----SRGICQCE 712
                             C+C P  TG  C  ST+ C +  C + G C        C C 
Sbjct: 752 -----------------YCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCA 794

Query: 713 EGWVGPTCEER---SC-HSHCTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGC 764
            G+ GP CE +   SC  S C     C+D     +C C  G+ G  C     L A +   
Sbjct: 795 MGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKP-- 852

Query: 765 PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQ 824
              C  N  C      +HC+C  GW+G  CN+ +       L    D  + C +   C  
Sbjct: 853 ---CPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVD 909

Query: 825 SN----CYISPLCQGS 836
           S     C+  P  QGS
Sbjct: 910 SGPSYFCHCPPGFQGS 925



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 97/372 (26%), Positives = 141/372 (37%), Gaps = 76/372 (20%)

Query: 499  MDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTN-CNGNGECI---SGH-CHCFPGFL 553
            +D GP Y      G      F  +   + ++ C +  C     C+   SG+ C C PG+ 
Sbjct: 908  VDSGPSYFCHCPPG------FQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYD 961

Query: 554  GPDCAR--DSC---PVLCGGNGEYEKG--HCVCRHGWKGPECDVPEEQCIDPTCFGHGTC 606
            G +C++  D+C   P    G    + G  HC C  G+ G  C+   ++C+D  C   GT 
Sbjct: 962  GQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTA 1021

Query: 607  IMG------VCICVPGYKGEICEEE--DCLDPMCSNHGICVKGE-------CHCSTGWGG 651
                      C C+PG+ G+ CE E   C    C + G C           CHC  G+ G
Sbjct: 1022 ACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEG 1081

Query: 652  VNCETPLPVCQEQCSGHGTFLLDAGV------CSCDPKWTGSDCSTELCTMECGS----- 700
              C    P C      HG   L +        C+C   + G DC T      CG      
Sbjct: 1082 PTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCL 1141

Query: 701  -HGVCSRGI--------CQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCE--CS-PG--W 746
             +G CS           C C     GP C++      C   G+  DG C+  CS PG  W
Sbjct: 1142 YNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKG-C--EGRSGDGACDAGCSGPGGNW 1198

Query: 747  EGDHCTIAHYLDAVRDGCPG-----LCFGNGRCTLDQNGWHCV-----CQVGWSGTGCNV 796
            +G  C++   +     GCP      L F +G+C    +   C+     C+   +   C  
Sbjct: 1199 DGGDCSLG--VPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCE---TPPACTP 1253

Query: 797  VMEMLCGDNLDN 808
              +  C D+  N
Sbjct: 1254 AYDQYCHDHFHN 1265



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 81/317 (25%), Positives = 108/317 (34%), Gaps = 94/317 (29%)

Query: 528  MDDCSTN-CNGNGECISG----HCHCFPGFLGPDCARDSCPVL---CGGNGEY------E 573
            +D C +  C+ +G C       HC C PGF+G  C  D    L   C   G         
Sbjct: 969  LDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLAN 1028

Query: 574  KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC-------IMGVCICVPGYKGEICEEE- 625
              +C C  G  G  C+V  + C    CF  GTC       +  +C C  G++G  C    
Sbjct: 1029 AFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA 1088

Query: 626  -DCLDPMCSNHGICVKG-------ECHCSTGWGGVNCETPL------------------- 658
              C    C + G+C+          C C +G+GG +C TP                    
Sbjct: 1089 PSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSE 1148

Query: 659  -------------------PVCQEQ----CSGH-GTFLLDAGVCSCDPKWTGSDCSTELC 694
                               P CQ+     C G  G    DAG       W G DCS  + 
Sbjct: 1149 TTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVP 1208

Query: 695  T--MECGSHGVC----SRGIC--QCEEG---WVGPTCE---------ERSCHSHCTEHGQ 734
                 C SH  C      G C  QC+     + G  CE         ++ CH H   +G 
Sbjct: 1209 DPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHF-HNGH 1267

Query: 735  CKDGKCECSPGWEGDHC 751
            C+ G      GW+G  C
Sbjct: 1268 CEKGCNTAECGWDGGDC 1284


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  132 bits (331), Expect = 6e-30
 Identities = 104/338 (30%), Positives = 130/338 (38%), Gaps = 48/338 (14%)

Query: 531 CSTNCNG-NGEC-ISGHCHCFPGFLGPDCARDSCPVL--CGGNGEYEKGHCVCRHGWKGP 586
           C   CN  +G C + G C C  G+ G  C  D C     C      E   C C   W G 
Sbjct: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFC--DECVPYPGCVHGSCVEPWQCNCETNWGGL 302

Query: 587 ECDVPEEQC-IDPTCFGHGTCIMGV-----CICVPGYKGEICE--EEDCLDPMCSNHGIC 638
            CD     C     C   GTCI        C C  GY G  CE  E  C    C+N G C
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362

Query: 639 VK----GECHCSTGWGGVNCETPLPVC-QEQCSGHGTFL--LDAGVCSCDPKWTGSDCST 691
            +     ECHC +GW G  C   +  C    C+  GT +  +D   C C  +W G+ C  
Sbjct: 363 HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQL 422

Query: 692 ELCTME---CGSHGVCSRGI----CQCEEGWVGPTC--EERSCHSHCTEHGQCKD----G 738
           +    E   C +   C   I    C C  GW G  C      C   C   G CKD     
Sbjct: 423 DANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGY 482

Query: 739 KCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCTLDQNGWHCVCQVGWSGTGCNVV 797
           +C C  G+ G HC +       RD C    C   G C    +G+HC C  G+SG  C V 
Sbjct: 483 QCVCPRGFGGRHCELE------RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 536

Query: 798 MEMLCGDNLDNDG------DGLTDCVDPDCCQQSNCYI 829
           ++ LC  +   +G      +G   C  PD     NC +
Sbjct: 537 VD-LCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573



 Score =  121 bits (304), Expect = 8e-27
 Identities = 103/361 (28%), Positives = 147/361 (40%), Gaps = 58/361 (16%)

Query: 535 CNGNGECISGH-----CHCFPGFLGPDC--ARDSC---PVLCGGN-GEYEKG-HCVCRHG 582
           C   G CI+       C C  G+ G +C  A  +C   P   GG+  E   G  C C  G
Sbjct: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSG 376

Query: 583 WKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEIC--EEEDCLDPMCSNHG 636
           W GP C +  ++C    C   GTC+  V    CIC   + G  C  +  +C    C N  
Sbjct: 377 WSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAF 436

Query: 637 IC---VKG-ECHCSTGWGGVNCETPLPVCQEQCSGHGTF--LLDAGVCSCDPKWTGSDCS 690
            C   + G  C C  GW G+NC   +  C+ QC   GT   L++   C C   + G  C 
Sbjct: 437 SCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496

Query: 691 ---TELCTMECGSHGVC---SRGI-CQCEEGWVGPTCE---ERSCHSHCTEHGQC----K 736
               E  +  C S G+C   + G  C C +G+ GP CE   +    S C    +C     
Sbjct: 497 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG 556

Query: 737 DGKCECSPGWEGDHCTIAHY-----LDAVRDGC-------------PGLCFGNGRCTLDQ 778
           D  C C   + G +C++           V DGC              G+C  +GRC    
Sbjct: 557 DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP 616

Query: 779 NG-WHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSP 837
            G + C+C  G++GT C+  ++   G    N G  + D VD   C   + +   LC  +P
Sbjct: 617 GGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNP 675

Query: 838 D 838
           +
Sbjct: 676 N 676



 Score =  118 bits (296), Expect = 7e-26
 Identities = 93/323 (28%), Positives = 125/323 (38%), Gaps = 70/323 (21%)

Query: 575 GHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC-IMGVCICVPGYKGEICEEEDCLDPMCS 633
           G+  C  GW G EC   E  C       HG C + G C C  G++G  C+E  C+     
Sbjct: 227 GNKACMDGWMGKECK--EAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDE--CVPYPGC 282

Query: 634 NHGICVKG-ECHCSTGWGGVNCETPLPVC--QEQCSGHGTFL---LDAGVCSCDPKWTGS 687
            HG CV+  +C+C T WGG+ C+  L  C     C+  GT +    D   C+C   ++G 
Sbjct: 283 VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342

Query: 688 DC--STELCTME-CGSHGVC----SRGICQCEEGWVGPTCE---ERSCHSHCTEHGQCKD 737
           +C  +   CT   C + G C    S   C C  GW GPTC    +    + C   G C D
Sbjct: 343 NCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402

Query: 738 --------------------------GK----------------CECSPGWEGDHCTIAH 755
                                     GK                C+C PGW+G +C I  
Sbjct: 403 QVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI-- 460

Query: 756 YLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTD 815
               V D C G C   G C    NG+ CVC  G+ G  C +  +  C  +  + G    D
Sbjct: 461 ---NVND-CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE-CASSPCHSGGLCED 515

Query: 816 CVDPDCCQQSNCYISPLCQGSPD 838
             D   C     +  PLC+   D
Sbjct: 516 LADGFHCHCPQGFSGPLCEVDVD 538



 Score =  112 bits (281), Expect = 4e-24
 Identities = 111/375 (29%), Positives = 137/375 (36%), Gaps = 66/375 (17%)

Query: 519 FVLTTAIEIMDDC-STNCNGNGECISG----HCHCFPGFLGPDC---ARDSCPVLCGGNG 570
           F  T   E +DDC    C   G CI       C C  G+ G  C     D  P  C   G
Sbjct: 628 FTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687

Query: 571 E----YEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMG----VCICVPGYKGEIC 622
                    +C C  GWKG  C   E QC   TC   GTC        C C PG+KG  C
Sbjct: 688 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747

Query: 623 ---EEEDCLDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDA 675
              +   CL   C N G CV       C C  GW G  C      C      +G   +D 
Sbjct: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD- 806

Query: 676 GV----CSCDPKWTGSDCS---TELCTMECGSHGVCSRGI----CQCEEGWVGPTCEE-- 722
           GV    C C P + G DC     E  +  C     C   I    C C  G  GP C+E  
Sbjct: 807 GVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866

Query: 723 ---RSCHSHCT--EHG----------QCKDGKCECSPGWEG-DHCTIAHYLDAVRDGCPG 766
              RSC S  T   HG          +C DG+ +CS  W G   C +A   +A+   CP 
Sbjct: 867 GFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP- 925

Query: 767 LCFGNGRCTLDQNGWHCV---CQVGWSGTGCNVVMEMLC---GDNLDNDGDGLTDCVDPD 820
                G+  L++    C+   C+  W   G        C     +LDN+   LT   + D
Sbjct: 926 ----LGQRCLEKAPGQCLRPPCE-AWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRD 980

Query: 821 CCQQSNCYISPLCQG 835
              Q    +  +C G
Sbjct: 981 HVPQGTT-VGAICSG 994



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 55/213 (25%), Positives = 76/213 (35%), Gaps = 41/213 (19%)

Query: 661 CQEQCSGHGTFLLDA-GVCSCDPKWTGSDCSTELCTMECGS-HGVCS-RGICQCEEGWVG 717
           C+ +    G +  D  G  +C   W G +C   +C   C   HG C+  G C+C  GW G
Sbjct: 211 CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQG 270

Query: 718 PTCEERSCHSHCTEHGQC-KDGKCECSPGWEG-------DHCTIAHYL-----------D 758
             C+E   +  C  HG C +  +C C   W G       ++C   H             D
Sbjct: 271 RFCDECVPYPGCV-HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329

Query: 759 AVRDGCP-----------------GLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEML 801
             R  CP                   C   G C    +G+ C C  GWSG  C + ++  
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE- 388

Query: 802 CGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
           C  N    G    D VD   C     ++   CQ
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQ 421


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  132 bits (331), Expect = 6e-30
 Identities = 92/320 (28%), Positives = 130/320 (40%), Gaps = 48/320 (15%)

Query: 525  IEIMDDCSTNCNGNGECI----SGHCHCFPGFLGPDCA---RDSCPVLCGGNGEY----E 573
            I++ D    +C   G+C     +  C C PGF G  C     +     C  NG       
Sbjct: 889  IDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTN 948

Query: 574  KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDC 627
            +  C C   + GP C++   +C    C     C+       C+C PGY G  CE   ++C
Sbjct: 949  RFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDEC 1008

Query: 628  LDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHG--TFLLDAGVCSCD 681
            L   C + G+C+ G     C C +G+ G +CET    C      HG  T L++   CSCD
Sbjct: 1009 LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCD 1068

Query: 682  PKWTGSDCSTEL--CT-MECGSHGVCSRGI----CQCEEGWVGPTCEER--SCHSH---- 728
               T + C  ++  CT + C + G C +      C C  G+ G  CE+   +C       
Sbjct: 1069 ADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNS 1128

Query: 729  --CTEHGQCKDGK-----CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGW 781
              C   G C DG      C C PG+ G  C I      + +     C     C    NG+
Sbjct: 1129 VICLNGGICVDGPGHTFDCRCLPGFSGQFCEIN-----INECSSSPCLHGADCEDHINGY 1183

Query: 782  HCVCQVGWSGTGCNVVMEML 801
             C CQ GWSG  C   +E +
Sbjct: 1184 VCKCQPGWSGHHCENELECI 1203



 Score =  114 bits (284), Expect = 2e-24
 Identities = 103/367 (28%), Positives = 145/367 (39%), Gaps = 73/367 (19%)

Query: 528  MDDCSTN-CNGNGEC----ISGHCHCFPGFLGPDCARDS--CPVL-CGGNGE----YEKG 575
            +DDC  N C  N  C    +S  C C   + G  C ++S  C +  C  N      Y+  
Sbjct: 734  IDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSY 793

Query: 576  HCVCRHGWKGPECDVPEEQCIDPTCFGHGTC----IMG--VCICVPGYKGEICEEE---- 625
             C C  GW G  C     +C    C   G C    I G  VC+C P Y G+ C +     
Sbjct: 794  RCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLC 853

Query: 626  DCLDPMCSNHGICV-----KGECHCSTGWGGVNCETPLPVCQ-EQCSGHGTF--LLDAGV 677
            D L   C N+  C+        C C   + G NCE  +  C    C  +G    +++   
Sbjct: 854  DLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFR 913

Query: 678  CSCDPKWTGSDCSTEL--CTME-CGSHGVC----SRGICQCEEGWVGPTCE---ERSCHS 727
            C C P ++GS C  E+  C+ E C ++G C    +R  C CE  + GP CE    +   S
Sbjct: 914  CICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKIS 973

Query: 728  HCTEHGQC---KDG-KCECSPGWEGDHCTIAHYLDAVRDGC-PGLCFGNGRCTLDQNGWH 782
             C +   C    DG  C C+PG+ G +C I        D C    C  +G C    N + 
Sbjct: 974  PCLDEENCVYRTDGYNCLCAPGYTGINCEIN------LDECLSEPCLHDGVCIDGINHYT 1027

Query: 783  CVCQVGWSGTGC---------NVVMEMLCGDNLDN-----DGDG--------LTDCVDPD 820
            C C+ G+ GT C         N  +   C + ++      D DG        + DC    
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP 1087

Query: 821  CCQQSNC 827
            C  +  C
Sbjct: 1088 CMNEGFC 1094



 Score =  104 bits (259), Expect = 1e-21
 Identities = 86/330 (26%), Positives = 131/330 (39%), Gaps = 62/330 (18%)

Query: 556 DCARDSCPVLCGGNGEYEKGHCV--CRHGWKGPECDVPEEQCIDPTCFGHGTCIMG---- 609
           DC   SC    G    + +G+    C  G+KG +C++  ++C    C    TCI      
Sbjct: 646 DCKSASCKN--GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNY 703

Query: 610 --------------VCICVPGYKGEICEE--EDCLDPMCSNHGIC----VKGECHCSTGW 649
                          C+C PGY G  CE+  +DC+   C ++  C    +  +C C + W
Sbjct: 704 FCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDW 763

Query: 650 GGVNCETPLPVCQ-EQCSGHGTF--LLDAGVCSCDPKWTGSDCSTEL--CTME-CGSHGV 703
            G  CE     C+   C  + T   L  +  C C   WTG +CS E+  C  + C + G+
Sbjct: 764 EGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGL 823

Query: 704 CSRG------ICQCEEGWVGPTCEER-----SCHSHCTEHGQC-----KDGKCECSPGWE 747
           C         +C C   + G  C +R       H+ C  +  C      +  C C   +E
Sbjct: 824 CHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFE 883

Query: 748 GDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLD 807
           G +C I      V+D     C   G C    N + C+C+ G+SG+ C + +     +   
Sbjct: 884 GKNCEI-----DVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCK 938

Query: 808 NDGDGLTDCVDPDCCQQSNC---YISPLCQ 834
           N+G     CVD       NC   Y  P C+
Sbjct: 939 NNG----TCVDLTNRFFCNCEPEYHGPFCE 964



 Score = 89.4 bits (220), Expect = 5e-17
 Identities = 70/251 (27%), Positives = 97/251 (38%), Gaps = 60/251 (23%)

Query: 528  MDDC-STNCNGNGECISG----HCHCFPGFLGPDCARD-----SCPVLCGGNGEYEKGH- 576
            +D+C S  C  +G CI G     C C  GF G  C  +     S P L G   E    + 
Sbjct: 1005 LDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYP 1064

Query: 577  CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDCLDP 630
            C C       +C +    C    C   G C        CIC  GY G  CE+  ++C +P
Sbjct: 1065 CSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEP 1124

Query: 631  -----MCSNHGICVKG-----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSC 680
                 +C N GICV G     +C C  G+ G  CE                 ++   CS 
Sbjct: 1125 ELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE-----------------ININECSS 1167

Query: 681  DPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCE-ERSCHSHCTEHGQCKDGK 739
             P   G+DC   +           +  +C+C+ GW G  CE E  C  +   H  C + +
Sbjct: 1168 SPCLHGADCEDHI-----------NGYVCKCQPGWSGHHCENELECIPNSCVHELCMENE 1216

Query: 740  ----CECSPGW 746
                C C+PG+
Sbjct: 1217 PGSTCLCTPGF 1227



 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 55/232 (23%), Positives = 87/232 (37%), Gaps = 48/232 (20%)

Query: 588 CDVPEEQCIDPTCFGHGTC--IMGVCI--CVPGYKGEICEEE--DCLDPMCSNHGICVK- 640
           C++  E C   +C    T   + G     CVPG+KG  CE +  +C    C N   C+  
Sbjct: 640 CEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQ 699

Query: 641 -GECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTEL--CTME 697
            G   C        C  P  V            +D   C C+P + G  C  ++  C + 
Sbjct: 700 PGNYFCQ-------CVPPFKV------------VDGFSCLCNPGYVGIRCEQDIDDCILN 740

Query: 698 CGSHGVCSRGI-----CQCEEGWVGPTCEERS-------CHSHCTEHGQCKDGKCECSPG 745
              H    + +     C C   W G  CE+ S       C ++ T     K  +CEC+ G
Sbjct: 741 ACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSG 800

Query: 746 WEGDHCTIAHYLDAVRDGCPGLCFGNGRC--TLDQNGWHCVCQVGWSGTGCN 795
           W G +C+     + + +     C   G C  +     + C+C   ++G  C+
Sbjct: 801 WTGQNCS-----EEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCH 847



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 52/207 (25%), Positives = 73/207 (35%), Gaps = 39/207 (18%)

Query: 531  CSTNCNG--NGECISGHC---------HCFPGFLGPDCA---RDSCPVLCGGNGEYEKGH 576
            C TN N   +  C+ G C          C        C     D   + C   G  +K  
Sbjct: 1039 CETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSA 1098

Query: 577  ----CVCRHGWKGPECDVPEEQCIDPT-----CFGHGTCIMGV-----CICVPGYKGEIC 622
                C+C  G+ G  C+   + C +P      C   G C+ G      C C+PG+ G+ C
Sbjct: 1099 HGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFC 1158

Query: 623  EEE--DCLDPMCSNHGIC---VKGE-CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG 676
            E    +C    C +   C   + G  C C  GW G +CE  L      C        + G
Sbjct: 1159 EININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPG 1218

Query: 677  -VCSCDPKW----TGSDCSTELCTMEC 698
              C C P +     G  C  E+  + C
Sbjct: 1219 STCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 65/264 (24%), Positives = 92/264 (34%), Gaps = 48/264 (18%)

Query: 535 CNGNGECISG------HCHCFPGFLGPDCAR-DSCPVL-CGGNG---------EYEKGHC 577
           C+G+G+C+S        CHC P F G  C   D+C    C  NG         + +   C
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242

Query: 578 VCRHGWKGPECDVPEEQCIDPTCFGHGTCI-----MGVCICVPGYKGEICE--EEDCLDP 630
           VC   + G  C     QC    CF HG C        +C C   + G  CE   + C+  
Sbjct: 243 VCHPPFTGKNCSEIIGQCQPHVCF-HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301

Query: 631 MCSNHGICVKGEC----HCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG---VCSCDPK 683
           +    GIC          C  G    N ET +         +GT  +      +C C P 
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361

Query: 684 WTGSDC---STELCTMECGSHGVCSR----GICQCEEGWVGPTCEERSCHS-----HCTE 731
           +T   C    T   +    ++  C +      C C  G+    CE+   H      +C  
Sbjct: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLN 421

Query: 732 HGQCKD----GKCECSPGWEGDHC 751
              C +     K  C PG   + C
Sbjct: 422 EEWCFNIIGRFKYVCIPGCTKNPC 445



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 49/151 (32%), Positives = 66/151 (43%), Gaps = 27/151 (17%)

Query: 525  IEIMDDCSTNCNGNGECI-SGH---CHCFPGFLGPDCAR--DSCP------VLC--GGNG 570
            I+I D  S  C   G C  S H   C C  G+ G  C +  D+C       V+C  GG  
Sbjct: 1078 IKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGIC 1137

Query: 571  EYEKGH---CVCRHGWKGPECDVPEEQCIDPTCFGHGTC---IMG-VCICVPGYKGEICE 623
                GH   C C  G+ G  C++   +C    C     C   I G VC C PG+ G  CE
Sbjct: 1138 VDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197

Query: 624  EE-DCLDPMCSNHGICVKGE----CHCSTGW 649
             E +C+   C  H +C++ E    C C+ G+
Sbjct: 1198 NELECIPNSCV-HELCMENEPGSTCLCTPGF 1227



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 42/141 (29%), Positives = 60/141 (42%), Gaps = 24/141 (17%)

Query: 602 GHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKG------ECHCSTGWGGVNCE 655
           G   C +G+ + V   K + C+E       CS HG C+         CHC   + G  C+
Sbjct: 155 GPSPCPLGLRLNVT-VKQQFCQES-LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ 212

Query: 656 TPLPVCQ-EQCSGHGTFLL-------DAGVCSCDPKWTGSDCSTEL--CTMECGSHGVCS 705
             L  C  + C  +G+ +         A  C C P +TG +CS  +  C      HG CS
Sbjct: 213 E-LDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCS 271

Query: 706 R-----GICQCEEGWVGPTCE 721
                  IC+C+E + GP CE
Sbjct: 272 NITSNSFICECDEQFSGPFCE 292



 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 89/404 (22%), Positives = 134/404 (33%), Gaps = 114/404 (28%)

Query: 528 MDDCSTN-CNGNGECISGH---------CHCFPGFLGPDCAR--DSC-PVLC-GGNGEYE 573
           +D CS   C  NG CI+           C C P F G +C+     C P +C  GN    
Sbjct: 214 LDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNI 273

Query: 574 KGH---CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMG--------------------- 609
             +   C C   + GP C+V  + C+    +  G C                        
Sbjct: 274 TSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDV 333

Query: 610 ---------------------VCICVPGYKGEICE--EEDCLDPMCSNHGICVKGE---- 642
                                +CIC P +   +C+  +  C      N+  C K E    
Sbjct: 334 SEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYP 393

Query: 643 CHCSTGWGGVNCETPLPVC---------QEQC---SGHGTFLLDAGVCSCDPKWTGSD-- 688
           C C +G+   NCE  +  C         +E C    G   ++   G C+ +P W   +  
Sbjct: 394 CSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG-CTKNPCWFLKNVY 452

Query: 689 -CSTELCTMECGSHGVC-SRGICQCEEGW-VG-PTCEERSCH----------SHCTEHGQ 734
                LC      HG+C  +G  Q E  W +G    E   C           ++CTE   
Sbjct: 453 LIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTE--- 509

Query: 735 CKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG--WHCVCQVGWSGT 792
             D      P      C   H      +G   +C     C  +++   +  +C + W+G 
Sbjct: 510 --DATYVNDPEDNNSSCWFPH------EGTKEICANGCSCLSEEDSQEYRYLCFLRWAG- 560

Query: 793 GCNVVMEMLCGDNLDNDGDGLTDCVDP---DCCQQSNCYISPLC 833
             N+ +E    D+ +N+      C D      C  S  YI  LC
Sbjct: 561 --NMYLENTT-DDQENECQHEAVCKDEINRPRCSCSLSYIGRLC 601



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 31/101 (30%), Positives = 39/101 (38%), Gaps = 11/101 (10%)

Query: 580  RHGWKGPECDVPEEQCIDPTCFGHGTCIMG----VCICVPGYKGEICEEEDCLDPMCSNH 635
            RHG     C VP   C    C  +GTCI       C C   Y G++C+   C +  C N 
Sbjct: 2326 RHGKNIENCHVP--WCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNG 2383

Query: 636  GICVKGE-----CHCSTGWGGVNCETPLPVCQEQCSGHGTF 671
              CV        C C  G  G  C   + + Q + SG   F
Sbjct: 2384 ATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAF 2424



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 31/132 (23%), Positives = 50/132 (37%), Gaps = 20/132 (15%)

Query: 720 CEERSCHSHCTEHGQC------KDGKCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNG 772
           C+E      C+ HG+C      K   C C P + G +C          D C    C  NG
Sbjct: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL-------DACSFKPCKNNG 226

Query: 773 RC-----TLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
            C       D+  + CVC   ++G  C+ ++   C  ++   G+      +   C+    
Sbjct: 227 SCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ-CQPHVCFHGNCSNITSNSFICECDEQ 285

Query: 828 YISPLCQGSPDP 839
           +  P C+ S  P
Sbjct: 286 FSGPFCEVSAKP 297



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 30/125 (24%), Positives = 46/125 (36%), Gaps = 22/125 (17%)

Query: 689 CSTELCTMECGSHGVCSRGI------CQCEEGWVGPTCEERSCHSH--CTEHGQCKDGK- 739
           C   L +  C  HG C          C C+  + G  C+E    S   C  +G C + + 
Sbjct: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233

Query: 740 --------CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSG 791
                   C C P + G +C+     + +    P +CF      +  N + C C   +SG
Sbjct: 234 NWDEQAYECVCHPPFTGKNCS-----EIIGQCQPHVCFHGNCSNITSNSFICECDEQFSG 288

Query: 792 TGCNV 796
             C V
Sbjct: 289 PFCEV 293



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 16/75 (21%)

Query: 597  DPTCFGHGTCIMG----------VCICVPGYKGEICEEE-DCLDPMCSNHGICVKGE--- 642
            D T  G+ TC  G           C C+P + G  C +   CL+ +C +  +C+  +   
Sbjct: 2875 DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFS 2934

Query: 643  --CHCSTGWGGVNCE 655
              C C+ GW G  CE
Sbjct: 2935 YSCLCTLGWVGRYCE 2949



 Score = 41.6 bits (96), Expect = 0.011
 Identities = 30/106 (28%), Positives = 43/106 (40%), Gaps = 17/106 (16%)

Query: 692  ELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHS--HCTEHGQCKDGKCECSPGWEGD 749
            EL   E G+ G  + G C       G  C   +C +   CT +G      C C P W G+
Sbjct: 2857 ELQLTEFGAKGGSNVGDCD------GTACGYNTCRNGGECTVNGTTFS--CRCLPDWAGN 2908

Query: 750  HCTIAHYLDAVRDGCPGLCFGNGRCTLDQN-GWHCVCQVGWSGTGC 794
             C     +  + +    LC     C  DQ+  + C+C +GW G  C
Sbjct: 2909 TCN--QSVSCLNN----LCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948



 Score = 37.4 bits (85), Expect = 0.20
 Identities = 24/101 (23%), Positives = 34/101 (33%), Gaps = 11/101 (10%)

Query: 700  SHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDA 759
            S G C    C   +   G TC E     +C            C+ GW+G  CT       
Sbjct: 2605 SVGQCHASPCSLMKCGNGGTCIESGTSVYCN-----------CTTGWKGSFCTETVSTCD 2653

Query: 760  VRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEM 800
                 P  C     C    +G+ C C +G +G  C   + +
Sbjct: 2654 PEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSI 2694



 Score = 36.6 bits (83), Expect = 0.35
 Identities = 25/84 (29%), Positives = 32/84 (38%), Gaps = 12/84 (14%)

Query: 622  CEEEDCLDPMCSNHGICVKGE----CHCSTGWGGVNCETPLPVCQEQ------CSGHGTF 671
            C    C    C N G C++      C+C+TGW G  C   +  C  +      CS   T 
Sbjct: 2609 CHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATC 2668

Query: 672  L-LDAG-VCSCDPKWTGSDCSTEL 693
            + L  G  C C    TG  C   L
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYCEQAL 2692



 Score = 35.4 bits (80), Expect = 0.78
 Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 15/76 (19%)

Query: 600  CFGHGTCIMG----VCICVPGYKGEICEEE-DCLDPM------CSNHGICVK----GECH 644
            C   GTCI       C C  G+KG  C E     DP       CS    C+       C 
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCF 2678

Query: 645  CSTGWGGVNCETPLPV 660
            C  G  G+ CE  L +
Sbjct: 2679 CPLGTTGIYCEQALSI 2694



 Score = 35.4 bits (80), Expect = 0.78
 Identities = 20/71 (28%), Positives = 30/71 (42%), Gaps = 11/71 (15%)

Query: 664  QCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTME--CGSHGVCSRG-----ICQCEEGWV 716
            +C+ +GT       C C P W G+ C+  +  +   C    +C         C C  GWV
Sbjct: 2889 ECTVNGTTFS----CRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWV 2944

Query: 717  GPTCEERSCHS 727
            G  CE ++  S
Sbjct: 2945 GRYCENKTSFS 2955



 Score = 34.7 bits (78), Expect = 1.3
 Identities = 30/96 (31%), Positives = 34/96 (35%), Gaps = 27/96 (28%)

Query: 544  GHCHCFPGFLGPDCARDSCPVLCGGNGE--YEKG---HCVCRHGWKGPECDVPEEQCIDP 598
            G CH  P           C ++  GNG    E G   +C C  GWKG  C      C DP
Sbjct: 2607 GQCHASP-----------CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTC-DP 2654

Query: 599  T------CFGHGTCIM----GVCICVPGYKGEICEE 624
                   C    TCI       C C  G  G  CE+
Sbjct: 2655 EHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 32.3 bits (72), Expect = 6.6
 Identities = 26/97 (26%), Positives = 34/97 (35%), Gaps = 28/97 (28%)

Query: 641  GECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGV---CSCDPKWTGSDC--STELCT 695
            G+CH S              C     G+G   +++G    C+C   W GS C  +   C 
Sbjct: 2607 GQCHASP-------------CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCD 2653

Query: 696  MECGSHGVCSRG----------ICQCEEGWVGPTCEE 722
             E      CSRG           C C  G  G  CE+
Sbjct: 2654 PEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQ 2690


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  130 bits (326), Expect = 2e-29
 Identities = 103/370 (27%), Positives = 132/370 (35%), Gaps = 86/370 (23%)

Query: 531 CSTNCNGNGECISGH-CHCFPGFLGPDCAR------------DSCPVLCGGNGEYEKGHC 577
           C+  C  +G CI+ + C C PG+ G +C+               C    G       G C
Sbjct: 109 CADKCV-HGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGAC 167

Query: 578 VCRHGWKGPECDVPEEQCIDPT----------CFGHGTC--IMGVCICVPGYKGEICE-- 623
            C  G++G  C   E++C   T          C    TC  + G C C PGY G  CE  
Sbjct: 168 HCAAGFRGWRC---EDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDL 224

Query: 624 ----------EEDCLDPMCSNHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQC 665
                     E+ C    C N G+C  V GEC C +GW G  C  P P       C ++C
Sbjct: 225 CPPGKHGPQCEQRC---PCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQEC 281

Query: 666 SGHGTFLLDA--GVCSCDPKWTGSDCSTE--------LC--TMECGSHGVCSR--GICQC 711
             H     DA  G C C P +TG  C  E        LC  T +C + G C    G C C
Sbjct: 282 QCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLC 341

Query: 712 EEGWVGPTCEER---------------SCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHY 756
           E G+ G  CE R                CH   T       G+C C PGW G +C     
Sbjct: 342 EAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCS 401

Query: 757 LDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV-----VMEMLCGDNLDNDGD 811
                + C  +C        D     C C  G+ G  C+         + C        D
Sbjct: 402 PGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKND 461

Query: 812 GLTDCVDPDC 821
            +   VD  C
Sbjct: 462 AVCSPVDGSC 471



 Score =  130 bits (326), Expect = 2e-29
 Identities = 99/319 (31%), Positives = 128/319 (40%), Gaps = 78/319 (24%)

Query: 530 DCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECD 589
           +C  +  G  +  +G CHC PG+ G  C +D CPV  G  G      C C +G K     
Sbjct: 280 ECQCHNGGTCDAATGQCHCSPGYTGERC-QDECPV--GTYGVLCAETCQCVNGGK----- 331

Query: 590 VPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPM----CSNHGIC------- 638
                     C+     + G C+C  G+ GE CE   C + +    C     C       
Sbjct: 332 ----------CYH----VSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHS 377

Query: 639 ---VKGECHCSTGWGGVNC-ETPLP-----VCQEQCSGHGTFLLDA--GVCSCDPKWTGS 687
              + GEC C  GW G+ C ET  P      CQ+ CS       D+  G C+C P + G 
Sbjct: 378 CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGI 437

Query: 688 DCSTEL--------CTMECG--SHGVCS--RGICQCEEGWVGPTCEER--------SCH- 726
           DCST          C+  CG  +  VCS   G C C+ GW G  C  R         C+ 
Sbjct: 438 DCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNL 497

Query: 727 -SHCTEHGQCK--DGKCECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCT----LDQ 778
              C   G C   DG C C+PGW G+ C +       +DG  GL C     C+       
Sbjct: 498 TCQCLNGGACNTLDGTCTCAPGWRGEKCEL-----PCQDGTYGLNCAERCDCSHADGCHP 552

Query: 779 NGWHCVCQVGWSGTGCNVV 797
              HC C  GWSG  C+ V
Sbjct: 553 TTGHCRCLPGWSGVHCDSV 571



 Score =  125 bits (315), Expect = 4e-28
 Identities = 108/422 (25%), Positives = 150/422 (35%), Gaps = 128/422 (30%)

Query: 534 NCNGNGEC--ISGHCHCFPGFLGPDCARD--------SCPVLCGGNGEYE----KGHCVC 579
           +C    +C  ++G C C PGF G DC+          +C   CG   +       G C C
Sbjct: 414 SCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTC 473

Query: 580 RHGWKGPECDVPEEQCIDPT----------CFGHGTC--IMGVCICVPGYKGEICEEEDC 627
           + GW G +C +   +C   T          C   G C  + G C C PG++GE CE   C
Sbjct: 474 KAGWHGVDCSI---RCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELP-C 529

Query: 628 LDPM----------CSNHGIC--VKGECHCSTGWGGVNCET-----------PLP----- 659
            D            CS+   C    G C C  GW GV+C++            LP     
Sbjct: 530 QDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKN 589

Query: 660 --------------------VCQEQCS----GH-------------GTFLLDAGVCSCDP 682
                                CQ  CS    GH             G      G+C C P
Sbjct: 590 GASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLP 649

Query: 683 KWTGSDCSTELCTM-----------ECGSHGVCSR--GICQCEEGWVGPTCEE------- 722
            +TG+ C+ E+C              C ++G C+     CQC  GW+G  C +       
Sbjct: 650 GFTGALCN-EVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHW 708

Query: 723 -----RSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLD 777
                 +C+ H        DG+C+C+PGW G +CT    L      C  +C        D
Sbjct: 709 GPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCD 768

Query: 778 QNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDG-DGLTDCVDPDCCQQ--SNCYISPLCQ 834
                C C+ G+ G  C    E  C       G   + DC++   C      CY SP  +
Sbjct: 769 HISGQCTCRTGFMGRHC----EQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWK 824

Query: 835 GS 836
           G+
Sbjct: 825 GA 826



 Score =  117 bits (293), Expect = 2e-25
 Identities = 87/308 (28%), Positives = 119/308 (38%), Gaps = 69/308 (22%)

Query: 543 SGHCHCFPGFLGPDC----------ARDSCPVLC--GGNGEYEKGHCVCRHGWKGPECDV 590
           +GHC C PG+ G  C             S P  C  G +   + G C C  G++G  C  
Sbjct: 554 TGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTC-- 611

Query: 591 PEEQCIDPTCFGH-------------GTC--IMGVCICVPGYKGEICEE--------EDC 627
             ++   P  +GH             G C  I G+C C+PG+ G +C E        ++C
Sbjct: 612 --QRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC 669

Query: 628 LDPM-CSNHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQCSGHGTFLLDA--G 676
                C+N+G C  +   C C  GW G +C  P P       C   C+ H      A  G
Sbjct: 670 AGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG 729

Query: 677 VCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCK 736
            C C P WTG  C T+ C +  G +G     ICQC+ G     C+  S            
Sbjct: 730 ECKCTPGWTGLYC-TQRCPL--GFYGKDCALICQCQNG---ADCDHIS------------ 771

Query: 737 DGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
            G+C C  G+ G HC           GC  +C      T D     C C  GW G  C+ 
Sbjct: 772 -GQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830

Query: 797 VMEMLCGD 804
              ++ G+
Sbjct: 831 AGVIIVGN 838



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 45/159 (28%), Positives = 62/159 (38%), Gaps = 42/159 (26%)

Query: 535 CNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGN-------------GEYEKGHCVC 579
           C  NG C  I   C C+PG++G DC++   P   G N               Y+ G C C
Sbjct: 675 CTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYD-GECKC 733

Query: 580 RHGWKGPECD-------VPEEQCIDPTCFGHGTC--IMGVCICVPGYKGEICEEE----- 625
             GW G  C          ++  +   C     C  I G C C  G+ G  CE++     
Sbjct: 734 TPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGT 793

Query: 626 ---------DCLDPMCSNHGICVKGECHCSTGWGGVNCE 655
                    DCL+    +H   + G C+CS GW G  C+
Sbjct: 794 YGYGCRQICDCLNNSTCDH---ITGTCYCSPGWKGARCD 829



 Score = 45.4 bits (106), Expect = 7e-04
 Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 16/76 (21%)

Query: 530 DCST--NCNGNGEC--ISGHCHCFPGFLGPDC------------ARDSCPVLCGGNGEYE 573
           DC+    C    +C  ISG C C  GF+G  C             R  C  L     ++ 
Sbjct: 754 DCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHI 813

Query: 574 KGHCVCRHGWKGPECD 589
            G C C  GWKG  CD
Sbjct: 814 TGTCYCSPGWKGARCD 829


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  129 bits (323), Expect = 5e-29
 Identities = 100/353 (28%), Positives = 150/353 (42%), Gaps = 79/353 (22%)

Query: 529 DDCSTN-CNGNGECISG----HCHCFPGFLG-------PDCARDSCPVLCGGNGEYEKGH 576
           D+C+++ C     C  G     C C PG+ G        +CA D C        E  +  
Sbjct: 150 DECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYT 209

Query: 577 CVCRHGWKGPECDVPEEQCIDPTCFGHGTC--IMGV--CICVPGYKGEICE--EEDCLDP 630
           C+C H + G  C++  ++C    C    TC   +G   C C PG+ G+ CE   ++C   
Sbjct: 210 CICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQ 269

Query: 631 MCSNHGICVKGE----CHCS-TGWGGVNCETPLPVC-QEQCSGHGTF--LLDAGVCSCDP 682
            C + G+CV GE    C+C+ +G+ G +CET +P+C  + C  + T    +D   C C P
Sbjct: 270 PCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWP 329

Query: 683 KWTGSDCSTEL--CTME-CGSHGVC------------------------SRGICQCEEGW 715
            +TG+ C  +L  C    C S+G C                        S  +C C+ G+
Sbjct: 330 GYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGF 389

Query: 716 VGPTCEE--RSCHSHCTEHGQCKDGKCECSPGWEGDHC---TIAHYLDAVRD------GC 764
            G  CEE    C S+  ++G    G CE  PG    HC    ++      RD      GC
Sbjct: 390 TGIHCEEDVNECSSNPCQNG----GTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGC 445

Query: 765 PGL-CFGNGRCTLD----QNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDG 812
               C  NG C       Q+G+ C+C  G++G+ C +         L  +GDG
Sbjct: 446 THQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI------ATTLSFEGDG 492



 Score =  122 bits (306), Expect = 5e-27
 Identities = 94/348 (27%), Positives = 136/348 (39%), Gaps = 75/348 (21%)

Query: 529 DDCSTN-CNGNGECI------SGHCHCFPGFLGP-------DCARDSCPV--LCGGNGEY 572
           D C +N C G+  C+      S  C C PG+ G         C ++SC    +C  +  Y
Sbjct: 72  DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIY 131

Query: 573 EKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEIC--EEED 626
               C+C  G+ G  C++  ++C    C     C  G+    C CVPGY+G  C  E ++
Sbjct: 132 PV--CICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDE 189

Query: 627 CLDPMCSNHGICV----KGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDA---GVCS 679
           C    C N   C+    +  C C   + GVNCE  +  C  Q   +G    DA     C 
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCD 249

Query: 680 CDPKWTGSDCSTELCTMECGSH-----GVC----SRGICQCE-EGWVG-------PTCEE 722
           C P + G  C  EL T EC S      G+C    +R  C C   G+ G       P C  
Sbjct: 250 CAPGFLGDHC--ELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307

Query: 723 RSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCT------- 775
           + CH++ T      +  C C PG+ G  C I      + +     C  NG C        
Sbjct: 308 KPCHNNATCEDSVDNYTCHCWPGYTGAQCEI-----DLNECNSNPCQSNGECVELSSEKQ 362

Query: 776 -------------LDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDG 810
                         + +G+ C+CQ G++G  C   +     +   N G
Sbjct: 363 YGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGG 410



 Score =  100 bits (250), Expect = 2e-20
 Identities = 79/279 (28%), Positives = 107/279 (38%), Gaps = 38/279 (13%)

Query: 587 ECDVPEEQCIDPTCFGHGTCI------MGVCICVPGYKGEICEEE--DCLDPMCSNHGIC 638
           +CD  ++ C    C G  TC+        +C C PGY G ICE     C    C + GIC
Sbjct: 66  DCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGIC 125

Query: 639 ----VKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFL---LDAGVCSCDPKWTGSDCST 691
               +   C C  G+ G  CE     C      +G      +D   C C P + G  C  
Sbjct: 126 HQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDL 185

Query: 692 EL--CTME-CGSHGVC----SRGICQCEEGWVGPTCEER--SCHSH-CTEHGQCKDGK-- 739
           E+  C  + C +   C     R  C C   + G  CE     C S  C     C+D    
Sbjct: 186 EVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGA 245

Query: 740 --CECSPGWEGDHCTIAHYLDAVRDGCPGL-CFGNGRCTLDQNGWHCVCQ-VGWSGTGCN 795
             C+C+PG+ GDHC +        D C    C   G C   +N + C C   G++GT C 
Sbjct: 246 YFCDCAPGFLGDHCELN------TDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299

Query: 796 VVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
            +M  LC     ++     D VD   C     Y    C+
Sbjct: 300 TLMP-LCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCE 337



 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 65/243 (26%), Positives = 92/243 (37%), Gaps = 58/243 (23%)

Query: 560  DSCPVLCGGNGE--YEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGY 617
            +S P L GGN E  Y   HC C  GW G  C++  ++C    C  HG             
Sbjct: 1144 NSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCI-HG------------- 1189

Query: 618  KGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQE-QCSGHGTFLLDAG 676
                    +C D + + H       C C  G+ GVNCE  +  CQ  QC+   T +    
Sbjct: 1190 --------NCSDRVAAYH-------CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTN 1234

Query: 677  --VCSCDPKWTGSDC-STELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHG 733
               C C   +TG  C  + L +  CG+     +    C  G             +CTE  
Sbjct: 1235 GYSCLCFGNFTGKFCRQSRLPSTVCGNE----KTNLTCYNG------------GNCTEFQ 1278

Query: 734  QCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTG 793
               + KC C PG+ G+ C        + +     C   G C    N + C+C V ++G  
Sbjct: 1279 T--ELKCMCRPGFTGEWCE-----KDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGER 1331

Query: 794  CNV 796
            C V
Sbjct: 1332 CEV 1334



 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 60/242 (24%), Positives = 90/242 (37%), Gaps = 42/242 (17%)

Query: 494  GFIEYMDQGPWYLAFYND-----GKKMEQVFVLTTAIEIMDDC-------STNCNGNGEC 541
            G +  ++ G  YL+++ +      K  E+ F+  +   ++  C       S  C   G C
Sbjct: 1095 GCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNC 1154

Query: 542  ----ISGHCHCFPGFLGPDCAR--DSC---PVLCGGNGEYEKG-HCVCRHGWKGPECDVP 591
                 S HC C  G+ G  C    D C   P + G   +     HC C  G+ G  C+V 
Sbjct: 1155 EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVD 1214

Query: 592  EEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEEDCLDPMCSNHG---ICVKG--- 641
             + C    C    TCI       C+C   + G+ C +      +C N      C  G   
Sbjct: 1215 IDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNC 1274

Query: 642  -------ECHCSTGWGGVNCETPLPVC-QEQCSGHGTF--LLDAGVCSCDPKWTGSDCST 691
                   +C C  G+ G  CE  +  C  + C   G    LL+   C CD  + G  C  
Sbjct: 1275 TEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEV 1334

Query: 692  EL 693
            +L
Sbjct: 1335 DL 1336



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 54/211 (25%), Positives = 76/211 (36%), Gaps = 40/211 (18%)

Query: 604  GTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQE 663
            G   + VC   P   G  CE     D   S H       C C  GW G +CE  +  C  
Sbjct: 1136 GCLQLNVCNSNPCLHGGNCE-----DIYSSYH-------CSCPLGWSGKHCELNIDECFS 1183

Query: 664  QCSGHGTFL--LDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCE 721
                HG     + A  C+C+P +TG +C  ++    C SH        QC  G       
Sbjct: 1184 NPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDIDN--CQSH--------QCANG------- 1226

Query: 722  ERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAV--RDGCPGLCFGNGRCTLDQN 779
              +C SH   +       C C   + G  C  +     V   +     C+  G CT  Q 
Sbjct: 1227 -ATCISHTNGYS------CLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQT 1279

Query: 780  GWHCVCQVGWSGTGCNVVMEMLCGDNLDNDG 810
               C+C+ G++G  C   ++    D   N G
Sbjct: 1280 ELKCMCRPGFTGEWCEKDIDECASDPCVNGG 1310



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 40/142 (28%), Positives = 53/142 (37%), Gaps = 46/142 (32%)

Query: 528 MDDCSTN-CNGNGECI-----------------------SGH-CHCFPGFLGPDCARD-- 560
           +++C++N C  NGEC+                       SG+ C C PGF G  C  D  
Sbjct: 340 LNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVN 399

Query: 561 ---SCPVLCGGNGEYEKGHCVC--------RHGWKGPECDVPEEQCIDPTCFGHGTCIMG 609
              S P   GG  E   G+  C        R  + G +C      C    C  +GTCI  
Sbjct: 400 ECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPH 459

Query: 610 V--------CICVPGYKGEICE 623
                    C+C  GY G +CE
Sbjct: 460 FQDGQHGFSCLCPSGYTGSLCE 481



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 36/140 (25%), Positives = 48/140 (34%), Gaps = 26/140 (18%)

Query: 720 CEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGC-PGLCFGNGRC--TL 776
           C   SC ++ T     KD  C CS         +    D ++D C    C G+  C  T 
Sbjct: 34  CLSNSCQNNSTCKDFSKDNDCSCSDTAN----NLDKDCDNMKDPCFSNPCQGSATCVNTP 89

Query: 777 DQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGD------------------GLTDCVD 818
            +  + C C  G+SGT C   +   CG N    G                   G    +D
Sbjct: 90  GERSFLCKCPPGYSGTICETTIGS-CGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEID 148

Query: 819 PDCCQQSNCYISPLCQGSPD 838
            D C  S C    +CQ   D
Sbjct: 149 HDECASSPCQNGAVCQDGID 168



 Score = 34.7 bits (78), Expect = 1.3
 Identities = 22/82 (26%), Positives = 29/82 (35%), Gaps = 16/82 (19%)

Query: 768  CFGNGRCTLDQNGWHCVCQVGWSGTGC---------NVVMEMLCGDNL-------DNDGD 811
            C   G C    + +HC C +GWSG  C         N  +   C D +       +    
Sbjct: 1148 CLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTCEPGYT 1207

Query: 812  GLTDCVDPDCCQQSNCYISPLC 833
            G+   VD D CQ   C     C
Sbjct: 1208 GVNCEVDIDNCQSHQCANGATC 1229


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score =  128 bits (321), Expect = 9e-29
 Identities = 100/337 (29%), Positives = 119/337 (35%), Gaps = 75/337 (22%)

Query: 531 CSTNC----NGNGECISGHCHCFPGFLGPDCAR----DSCPVLCGGNGEYEK-------- 574
           C  +C     G  +  SG C C PG+ GP CA     D+  V C      E         
Sbjct: 404 CQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPID 463

Query: 575 GHCVCRHGWKGPECDVPEEQCIDPT----------CFGHGTCI--MGVCICVPGYKGEIC 622
           G CVC+ GW+   C VP   C   T          C     C    G C C PG+ G  C
Sbjct: 464 GECVCKEGWQRGNCSVP---CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHC 520

Query: 623 E--------EEDCLDPM-CSNHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQC 665
           +         E C     C +   C  V G C C  GW G  C    P       C   C
Sbjct: 521 QLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTC 580

Query: 666 S--GHGTFLLDAGVCSCDPKWTGSDC---------STELCTMECGSHGVC--SRGICQCE 712
           +    GT L + G C C P + G  C                +C +H  C  S G C C 
Sbjct: 581 TCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCL 640

Query: 713 EGWVGPTCEE--------RSCHSHCTEH--GQC--KDGKCECSPGWEGDHCTIAHYLDAV 760
            GW GP C +         +C   C  H  G C  +DG C C  GW G HC     L   
Sbjct: 641 AGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTF 700

Query: 761 RDGCPGLC-FGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
              C   C  G G     + G  CVC  G SG  C +
Sbjct: 701 GANCSQPCQCGPGEKCHPETG-ACVCPPGHSGAPCRI 736



 Score =  125 bits (315), Expect = 4e-28
 Identities = 101/362 (27%), Positives = 135/362 (37%), Gaps = 84/362 (23%)

Query: 535 CNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPE 592
           C+  G C   +G C C PG+ G  C R+ CPV                 G  G +C    
Sbjct: 278 CHNGGLCDRFTGQCRCAPGYTGDRC-REECPV-----------------GRFGQDCAETC 319

Query: 593 EQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPM----CSNHGIC---------- 638
           +   D  CF       G C+C  G+ G+ C +  C D      C     C          
Sbjct: 320 DCAPDARCFPAN----GACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHP 375

Query: 639 VKGECHCSTGWGGVNC------ETPLPVCQEQCS--GHGTFLLDAGVCSCDPKWTGSDCS 690
           + GEC C  GW G++C      +T  P CQE C     G     +G+C C P +TG  C+
Sbjct: 376 MNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCA 435

Query: 691 TELCT-----MECGSHGVCSRGI--------CQCEEGWVGPTCEER--------SCHS-- 727
           + LC      + C +   C   I        C C+EGW    C           SC++  
Sbjct: 436 S-LCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASC 494

Query: 728 HCTEHGQC--KDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVC 785
            C     C  + G C C+PGW G HC +        +GC   C  +     D     C C
Sbjct: 495 QCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQC 554

Query: 786 QVGWSGTGCNV-VMEMLCGDNLDNDGDGLTDCVDPDCC--QQSNC-----YISPLCQGSP 837
           Q GW G  C++   E L G N  N       C +   C  +  NC     +  P CQ S 
Sbjct: 555 QAGWMGARCHLSCPEGLWGVNCSN----TCTCKNGGTCLPENGNCVCAPGFRGPSCQRSC 610

Query: 838 DP 839
            P
Sbjct: 611 QP 612



 Score =  116 bits (291), Expect = 3e-25
 Identities = 94/335 (28%), Positives = 119/335 (35%), Gaps = 68/335 (20%)

Query: 530 DCSTNCNGNGECI--SGHCHCFPGFLGPDCARD--------SCPVLCGGNG---EYEKGH 576
           D   +C  N  C   SG C C  G   P+C +         +C   C  +G   + + G 
Sbjct: 145 DKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA 204

Query: 577 CVCRHGWKGPECDVPEEQ------CIDPTCFGHGTCIM---GVCICVPGYKGEICE---E 624
           C C     GP CDV   Q      C       +G       G C C PG+ G IC     
Sbjct: 205 CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCP 264

Query: 625 EDCLDPMCS------NHGICVK--GECHCSTGWGGVNCETPLPV------CQE--QCSGH 668
           E    P CS      N G+C +  G+C C+ G+ G  C    PV      C E   C+  
Sbjct: 265 EGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPD 324

Query: 669 GTFLLDAGVCSCDPKWTGSDCSTELCT-----MECGSHGVCSR----------GICQCEE 713
                  G C C+  +TG  C+  LC      + C +   C R          G C C  
Sbjct: 325 ARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLP 384

Query: 714 GWVGPTCEER--------SCHSHCT-EHG---QCKDGKCECSPGWEGDHCTIAHYLDAVR 761
           GW G  C E          C  HC   HG   Q   G C+C+PG+ G HC      D   
Sbjct: 385 GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYG 444

Query: 762 DGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
             C   C              CVC+ GW    C+V
Sbjct: 445 VNCSARCSCENAIACSPIDGECVCKEGWQRGNCSV 479



 Score =  115 bits (289), Expect = 5e-25
 Identities = 96/334 (28%), Positives = 123/334 (36%), Gaps = 74/334 (22%)

Query: 531 CSTNCNGNGECIS-GHCHCFPGFLGPDCARDSCPVL----------CGGNG--EYEKGHC 577
           C+  C  +G C++   C C PG+ G DC+ +  P +          CG N   + + G C
Sbjct: 105 CAQECV-HGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVC 163

Query: 578 VCRHGWKGPECDVP-EEQCIDPTCFGHGTC-------IMGVCICVPGYKGEICEEEDCLD 629
            C  G + P C  P       P C     C         G C C     G  C +  C  
Sbjct: 164 SCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSC-DVSCSQ 222

Query: 630 ----------PMCSNHGI--CVKGECHCSTGWGGVNCETPLPV------CQEQCSGHGTF 671
                       C N G+    +G C C  GW G  C  P P       C ++C  H   
Sbjct: 223 GTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGG 282

Query: 672 LLD--AGVCSCDPKWTGSDCSTEL--------C--TMECGSHGVC--SRGICQCEEGWVG 717
           L D   G C C P +TG  C  E         C  T +C     C  + G C CE G+ G
Sbjct: 283 LCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTG 342

Query: 718 PTCEER---------SCHSHCT---EHG-QC--KDGKCECSPGWEGDHCTIAHYLDAVRD 762
             C +R         SC + CT   EH   C   +G+C C PGW G HC  +   D    
Sbjct: 343 DRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGP 402

Query: 763 GCPG--LCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
           GC    LC   G C        C C  G++G  C
Sbjct: 403 GCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHC 434



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 55/186 (29%), Positives = 70/186 (37%), Gaps = 52/186 (27%)

Query: 530 DCSTNCN--GNGECI--SGHCHCFPGFLGPDCARDSC----------PVLCGGNG--EYE 573
           +CS  C     G C+  +G+C C PGF GP C R SC          P  C  +      
Sbjct: 575 NCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQR-SCQPGRYGKRCVPCKCANHSFCHPS 633

Query: 574 KGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCS 633
            G C C  GW GP+C  P                     C PG+ GE C  + C    C 
Sbjct: 634 NGTCYCLAGWTGPDCSQP---------------------CPPGHWGENC-AQTC---QCH 668

Query: 634 NHGIC--VKGECHCSTGWGGVNCETPLPV------CQE--QCSGHGTFLLDAGVCSCDPK 683
           + G C    G C C  GW G +C    P+      C +  QC        + G C C P 
Sbjct: 669 HGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPG 728

Query: 684 WTGSDC 689
            +G+ C
Sbjct: 729 HSGAPC 734



 Score = 42.0 bits (97), Expect = 0.008
 Identities = 43/161 (26%), Positives = 55/161 (34%), Gaps = 34/161 (21%)

Query: 693 LCTMECGSHGVC-SRGICQCEEGWVGPTCEER--------SCHSHCT--EHGQC--KDGK 739
           LC  EC  HG C +   CQC  GW G  C            C   C+   +  C  K G 
Sbjct: 104 LCAQEC-VHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGV 162

Query: 740 CECSPGWEGDH----CTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCN 795
           C C  G +  +    CT  +Y  A +  C   C G      D     C C    +G  C+
Sbjct: 163 CSCPSGLQPPNCLQPCTPGYYGPACQFRCQ--CHG---APCDPQTGACFCPAERTGPSCD 217

Query: 796 VVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGS 836
           V           + G     C     CQ    + +P  QGS
Sbjct: 218 VSC---------SQGTSGFFCPSTHSCQNGGVFQTP--QGS 247



 Score = 40.4 bits (93), Expect = 0.024
 Identities = 23/91 (25%), Positives = 29/91 (31%), Gaps = 6/91 (6%)

Query: 704 CSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDG 763
           C  G  +   G+  P C +   H  C    QC     +C PGW GD C+           
Sbjct: 90  CCHGFYE-SRGFCVPLCAQECVHGRCVAPNQC-----QCVPGWRGDDCSSECAPGMWGPQ 143

Query: 764 CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
           C   C      + D     C C  G     C
Sbjct: 144 CDKPCSCGNNSSCDPKSGVCSCPSGLQPPNC 174


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  127 bits (320), Expect = 1e-28
 Identities = 96/335 (28%), Positives = 126/335 (37%), Gaps = 71/335 (21%)

Query: 530  DCSTNCN-GNGEC--ISGHCHCFPGFLGPDCARD--------SCPVLC-----GGNGEYE 573
            +CS++C+ G   C  ++G C C PG  G DC  D         C  +C         + E
Sbjct: 739  NCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPE 798

Query: 574  KGHCVCRHGWKGPEC-DVPEEQCIDPTCF--------GHGTCIMGVCICVPGYKGEICEE 624
             G C+C  G+ G  C DV       P+C         GH     G C C PG+ G  C+ 
Sbjct: 799  TGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQR 858

Query: 625  E--------DCLDPM-CS-NHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQCS 666
                     DC  P  CS  HG C  + G C C  G+ G  CE   P       C+++C 
Sbjct: 859  ACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQ 918

Query: 667  GHGTFLLD--AGVCSCDPKWTGSDCS------------TELCTMECGSHGVCSRGICQCE 712
                   D  +G C+C   W G+ C                C    G+      G C C 
Sbjct: 919  CQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCP 978

Query: 713  EGWVGPTCEERSCHSH-----CTEHGQCKDG--------KCECSPGWEGDHCTIAHYLDA 759
             G  GP C E +C +H     C++   C +G        +C C+PGW G  C  A     
Sbjct: 979  AGRRGPRCAE-TCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGL 1037

Query: 760  VRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
              D C   C      T D    HC C  GW+G  C
Sbjct: 1038 YGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLAC 1072



 Score =  114 bits (286), Expect = 1e-24
 Identities = 103/372 (27%), Positives = 136/372 (36%), Gaps = 95/372 (25%)

Query: 529  DDCSTNCNGNGE---C--ISGHCHCFPGFLGPDCAR--------DSCPVLCG----GNGE 571
            +DC+  C   GE   C   +G C C  G+ GP C +          C  LCG    G+ +
Sbjct: 1169 EDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCD 1228

Query: 572  YEKGHCVCRHGWKGPECDVPEEQC-IDPTCF-----GHGTC---IMGVCICVPGYKGEIC 622
               G C C  G+ G +C++   Q    P C      G G     + G C+C PG  G  C
Sbjct: 1229 AATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRC 1288

Query: 623  E------------EEDCLDPMCSNHGIC--VKGECHCSTGWGGVNCETPLP------VCQ 662
            E            E  C    C N G+C    G C C  GW G +CE   P       C 
Sbjct: 1289 ERGCPQNRFGVGCEHTC---SCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACH 1345

Query: 663  EQCSGHGTFLLD--AGVCSCDPKWTGSDCSTELCTMEC--GSHGVCSRGICQCEEGWVGP 718
             +CS H     +   G C C P + G     + C   C  G HG   +G+C C+ G    
Sbjct: 1346 LECSCHNNSTCEPATGTCRCGPGFYG-----QACEHPCPPGFHGAGCQGLCWCQHG---A 1397

Query: 719  TCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQ 778
             C+  S             G+C C  G+ G  C       +  +GC   C  +G    D 
Sbjct: 1398 PCDPIS-------------GRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDP 1444

Query: 779  NGWHCVCQVGWSGTGCNV-----------VMEMLCGDNLDNDG-DGLTDCVDPDCCQQSN 826
                C+C  G SG  CN+            +   CG   D D   G   CVD        
Sbjct: 1445 VTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDG------- 1497

Query: 827  CYISPLC-QGSP 837
             Y+ P C +G P
Sbjct: 1498 -YMGPTCREGGP 1508



 Score =  110 bits (275), Expect = 2e-23
 Identities = 97/341 (28%), Positives = 125/341 (36%), Gaps = 79/341 (23%)

Query: 530  DCSTNC---NGNG-ECISGHCHCFPGFLGPDC------------ARDSCPVLCGGNGEYE 573
            +CS  C   NG   + + G CHC PG++GP C             R SC    GG  +  
Sbjct: 998  NCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPV 1057

Query: 574  KGHCVCRHGWKGPECDVPEEQCI----------DPTCFGHGTC--IMGVCICVPGYKGEI 621
             GHC C  GW G  C   E++C+             C   G C    G C+C  G+ G+ 
Sbjct: 1058 SGHCACPEGWAGLAC---EKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDK 1114

Query: 622  CEEEDCL----DPMCSNHGIC--------VKGECHCSTGWGGVNCETPLPV------CQE 663
            C +  CL       C+    C        V G C C  G+ G  CE   P       C +
Sbjct: 1115 C-QSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQ 1173

Query: 664  --QCSGHGTFLLDA-GVCSCDPKWTGSDCSTEL--------CTMECG--SHGVC--SRGI 708
              QC G       A G CSC   + G  C            C   CG  + G C  + G 
Sbjct: 1174 MCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA 1233

Query: 709  CQCEEGWVGP----TCEERSCHSHCTEHGQCKD--------GKCECSPGWEGDHCTIAHY 756
            C+C  G++G     TC +     +CT    C          G C C PG  G  C     
Sbjct: 1234 CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCP 1293

Query: 757  LDAVRDGCPGLC-FGNGRCTLDQNGWHCVCQVGWSGTGCNV 796
             +    GC   C   NG      NG  C C +GW+G  C +
Sbjct: 1294 QNRFGVGCEHTCSCRNGGLCHASNG-SCSCGLGWTGRHCEL 1333



 Score =  104 bits (260), Expect = 1e-21
 Identities = 115/448 (25%), Positives = 140/448 (31%), Gaps = 143/448 (31%)

Query: 534  NCNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEK---------------GH 576
            NC   G C  + G C C PG  G  C   +CP    G G  E+               G 
Sbjct: 612  NCANRGRCHRLYGACLCDPGLYGRFC-HLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGS 670

Query: 577  CVCRHGWKGPECDVP-EEQCIDPTCFGHGTCIMGV------------------------- 610
            C C+ G++G  C    E     P C+   TC +GV                         
Sbjct: 671  CSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQE 730

Query: 611  ---------------------------CICVPGYKGEICEEEDC-----------LDPMC 632
                                       C C PG  GE C E DC           + P C
Sbjct: 731  CPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDC-EADCPEGRWGLGCQEICPAC 789

Query: 633  SNHGIC--VKGECHCSTGWGGVNCETPLPV------CQEQCS--GHGTFLLDAGVCSCDP 682
             +   C    G C C  G+ G  C+   P       CQ +CS    G      G CSC P
Sbjct: 790  QHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAP 849

Query: 683  KWTGSDCSTEL--------CTMEC---GSHGVCS--RGICQCEEGWVGPTCEERSCHSH- 728
             WTG  C            C+  C     HG C    G+C CE G+VGP CE++    H 
Sbjct: 850  GWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHF 909

Query: 729  ---CTEHGQCK--------DGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLD 777
               C +  QC+         G C C  GW G  C  A         C   C        D
Sbjct: 910  GPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACD 969

Query: 778  QNGWHCVCQVGWSGTGC-----------NVVMEMLCGDNLDNDG-DGLTDC----VDPDC 821
                 C+C  G  G  C           N      C +    D   G   C    + P C
Sbjct: 970  AVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSC 1029

Query: 822  CQQ-------SNCYISPLCQ--GSPDPL 840
             Q         NC  S LCQ  G+ DP+
Sbjct: 1030 LQACPAGLYGDNCRHSCLCQNGGTCDPV 1057



 Score =  102 bits (255), Expect = 4e-21
 Identities = 96/345 (27%), Positives = 119/345 (34%), Gaps = 93/345 (26%)

Query: 532 STNCNGNGEC--ISGHCHCFPGFLGPDCARDSCP-----------VLCGGNGEYEK--GH 576
           S +C   G C  ++G C C PG  G +C  D CP             C   G   +  G 
Sbjct: 567 SCSCQNGGTCDSVTGACRCPPGVSGTNC-EDGCPKGYYGKHCRKKCNCANRGRCHRLYGA 625

Query: 577 CVCRHGWKGPECDVP-EEQCIDPTCFGHGTCIM----------GVCICVPGYKGEICEEE 625
           C+C  G  G  C +        P C     C+           G C C  G++GE C+ E
Sbjct: 626 CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAE 685

Query: 626 ---DCLDPMCSNHGIC--------VKGEC--HCSTGWGGVNCETPLPV------CQEQCS 666
                  P C     C        V GEC   C  G+ G +C    PV      C   CS
Sbjct: 686 CELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCS 745

Query: 667 -----GHGTFLLDAGVCSCDPKWTGSDCSTEL---------------------CTMECGS 700
                 HG      G C C P  TG DC  +                      C  E G+
Sbjct: 746 CGGAPCHGV----TGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGA 801

Query: 701 HGVCSRGI----CQ--CEEGWVGPTCEERSCHSHCTEHGQC--KDGKCECSPGWEGDHCT 752
             +C  G     CQ  C  GW GP+C+ R     C   G C    G C C+PGW G  C 
Sbjct: 802 -CLCLPGFVGSRCQDVCPAGWYGPSCQTR---CSCANDGHCHPATGHCSCAPGWTGFSCQ 857

Query: 753 IAHYLDAVRDGCPGLC---FGNGRCTLDQNGWHCVCQVGWSGTGC 794
            A         C   C    G+G C  D     C+C+ G+ G  C
Sbjct: 858 RACDTGHWGPDCSHPCNCSAGHGSC--DAISGLCLCEAGYVGPRC 900



 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 89/389 (22%), Positives = 116/389 (29%), Gaps = 133/389 (34%)

Query: 548 CFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPEC------DVPEEQC-IDPTC 600
           C     G DC+        GG        C C  GW G  C      D   + C    +C
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSC 570

Query: 601 FGHGTC--IMGVCICVPGYKGEICEE--------EDC----------------------- 627
              GTC  + G C C PG  G  CE+        + C                       
Sbjct: 571 QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDP 630

Query: 628 ---------------LDPMCSNHGICVK----------GECHCSTGWGGVNCETPL---- 658
                            P CS    CV+          G C C  G+ G  C+       
Sbjct: 631 GLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGY 690

Query: 659 --PVCQEQCSGHGTFLLD--AGVCS--CDPKWTGSDCSTEL--------CTMECGSHGVC 704
             P C + C+       D  +G C   C   + G DC  E         C+  C   G  
Sbjct: 691 FGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAP 750

Query: 705 SRGI---CQCEEGWVGPTCE------------ERSCHSHCTEHGQC--KDGKCECSPGWE 747
             G+   C+C  G  G  CE            +  C + C    +C  + G C C PG+ 
Sbjct: 751 CHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPA-CQHAARCDPETGACLCLPGFV 809

Query: 748 GDHCTIAHYLDAVRDGCPGLCFG---NGRCTLDQNG------WHCVCQVGWSGTGCNVVM 798
           G  C         +D CP   +G     RC+   +G       HC C  GW+G  C    
Sbjct: 810 GSRC---------QDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRAC 860

Query: 799 EMLCGDNLDNDGDGLTDCVDPDCCQQSNC 827
           +              T    PDC    NC
Sbjct: 861 D--------------TGHWGPDCSHPCNC 875



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 52/207 (25%), Positives = 69/207 (33%), Gaps = 60/207 (28%)

Query: 663 EQCSGHGTFLLDAGVCSCDPKWTGSDCSTELC-----------TMECGSHGVCS--RGIC 709
           + C   GT LL    C C   WTG  C+ E C           +  C + G C    G C
Sbjct: 525 DDCRNGGTCLLGLDGCDCPEGWTGLICN-ETCPPDTFGKNCSFSCSCQNGGTCDSVTGAC 583

Query: 710 QCEEGWVGPTCEE--------RSCHS--HCTEHGQCKD--GKCECSPGWEGDHCTIAHYL 757
           +C  G  G  CE+        + C    +C   G+C    G C C PG  G  C +    
Sbjct: 584 RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLT--- 640

Query: 758 DAVRDGCPGLCFGNG-----RC------TLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNL 806
                 CP   FG G     +C      + D+    C C+ G+ G  C    E+      
Sbjct: 641 ------CPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECEL------ 688

Query: 807 DNDGDGLTDCVDPDCCQQSNCYISPLC 833
                       P C Q   C +   C
Sbjct: 689 --------GYFGPGCWQACTCPVGVAC 707



 Score = 55.1 bits (131), Expect = 9e-07
 Identities = 70/270 (25%), Positives = 95/270 (35%), Gaps = 71/270 (26%)

Query: 620 EICEEEDCLDPMCSNHGICVKGE---CHCSTGWGGVNCETPLPVCQEQ---CSGHGTFLL 673
           E C   +C   +C + G CV G    CHC  G+ G  C+  +  C+     C        
Sbjct: 121 EGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTP 180

Query: 674 DAGVCSCDPKWT-GSDCSTELCTMECG-SHGVC---------SRGICQCEEGWV----GP 718
            + +C C P +   +D  T L    C   +G C         +R  CQC  G+     G 
Sbjct: 181 GSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGR 240

Query: 719 TCEERS-C---HSHCTEHGQCKDG--KCECSPGWE----GDHCTIAHYLDAVRDGCPGLC 768
            C  RS C   +  C    Q   G  +CEC  G++    G  C      + V +   GL 
Sbjct: 241 HCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKAC------EDVDECAAGLA 294

Query: 769 FGNGRCTLDQNGWHCVCQVGWS----GTGC-NVVMEM----------------------L 801
                C   Q  + CVC  G+     G  C  + ME+                      L
Sbjct: 295 QCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPL 354

Query: 802 C----GDNLDNDGD---GLTDCVDPDCCQQ 824
           C    G  LD D      + DC D  CCQQ
Sbjct: 355 CTCPRGYELDTDQRTCIDVDDCADSPCCQQ 384



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 88/356 (24%), Positives = 127/356 (35%), Gaps = 92/356 (25%)

Query: 530 DCSTN-CNGNGECISGH---CHCFPGFLGPDCAR--DSCPVLCGG--------NGEYEKG 575
           +CS + C   G C+ G    CHC PGF GP C    D C    GG         G Y   
Sbjct: 127 ECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSY--- 183

Query: 576 HCVCRHGWKGPECDVPEEQCIDPTCFGHGTC---------IMGVCICVPGYK----GEIC 622
            C C+ G++    D      I+    G+G C             C C PG++    G  C
Sbjct: 184 LCECKPGFR-LHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 242

Query: 623 EEEDCLDPMCSNHGIC------VKG--ECHCSTGW----GGVNCE------TPLPVCQEQ 664
                  P  + +G C      V+G   C C  G+     G  CE        L  C   
Sbjct: 243 VRR---SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHG 299

Query: 665 C-SGHGTFLLDAGVCSCDPKW----TGSDC---STELCTMECGSHGVCSRG--------I 708
           C +  G+F      C C   +     G  C     E+      ++G CS G        +
Sbjct: 300 CLNTQGSF-----KCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPL 354

Query: 709 CQCEEGWVGPTCEERSC--HSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPG 766
           C C  G+   T ++R+C     C +   C+   C  +PG     C   + L A   GC  
Sbjct: 355 CTCPRGYELDT-DQRTCIDVDDCADSPCCQQ-VCTNNPGGYECGCYAGYRLSADGCGCED 412

Query: 767 L--CFGN-----GRCTLDQNGWHCVCQVGW----SGTGCNVVMEMLCGDNLDNDGD 811
           +  C  +       CT     + C C+ G+       GC+ + E +    +D DG+
Sbjct: 413 VDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPM----VDLDGE 464



 Score = 37.4 bits (85), Expect = 0.20
 Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 3/44 (6%)

Query: 534  NCNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKG 575
            +C G  +C  +SG CHC  G++GP C R+  P+    N    +G
Sbjct: 1478 DCGGGADCDPVSGQCHCVDGYMGPTC-REGGPLRLPENPSLAQG 1520



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 25/96 (26%), Positives = 39/96 (40%), Gaps = 19/96 (19%)

Query: 705 SRGICQCEEGWVGPTCEERSCHSHCT-----EHGQCKDGK---CECSPGWEGDHCTIAHY 756
           +R + +C  GW+    EE    + C+       G+C  G    C C PG++G  C   + 
Sbjct: 104 ARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRC--QYD 161

Query: 757 LDAVR---DGCPGLCFGNGRCTLDQNGWHCVCQVGW 789
           +D  R    GC        RC      + C C+ G+
Sbjct: 162 VDECRTHNGGC------QHRCVNTPGSYLCECKPGF 191


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  122 bits (307), Expect = 4e-27
 Identities = 88/285 (30%), Positives = 119/285 (41%), Gaps = 32/285 (11%)

Query: 575 GHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC-IMGVCICVPGYKGEICEEEDCLDPMCS 633
           G+  C  GW G EC   E  C       HG C + G C C  G++G  C+E  C+     
Sbjct: 227 GNKACMDGWMGKECK--EAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDE--CVPYPGC 282

Query: 634 NHGICVKG-ECHCSTGWGGVNCETPLPVC--QEQCSGHGTFL---LDAGVCSCDPKWTGS 687
            HG CV+  +C+C T WGG+ C+  L  C     C+  GT +    D   C+C   ++G 
Sbjct: 283 VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342

Query: 688 DC--STELCTME-CGSHGVC----SRGICQCEEGWVGPTCE---ERSCHSHCTEHGQCKD 737
           +C  +   CT   C + G C    S   C C  GW GPTC    +    + C   G C D
Sbjct: 343 NCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402

Query: 738 G----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTG 793
                +C C   W G  C     LD   + C G C   G C    NG+ CVC  G+ G  
Sbjct: 403 QVDGFECICPEQWVGATC----QLDV--NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRH 456

Query: 794 CNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPD 838
           C +  +  C  +  + G    D  D   C     +  PLC+   D
Sbjct: 457 CELERDE-CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVD 500



 Score =  120 bits (300), Expect = 2e-26
 Identities = 90/302 (29%), Positives = 116/302 (38%), Gaps = 41/302 (13%)

Query: 531 CSTNCNG-NGEC-ISGHCHCFPGFLGPDCARDSCPVL--CGGNGEYEKGHCVCRHGWKGP 586
           C   CN  +G C + G C C  G+ G  C  D C     C      E   C C   W G 
Sbjct: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFC--DECVPYPGCVHGSCVEPWQCNCETNWGGL 302

Query: 587 ECDVPEEQC-IDPTCFGHGTCIMGV-----CICVPGYKGEICE--EEDCLDPMCSNHGIC 638
            CD     C     C   GTCI        C C  GY G  CE  E  C    C+N G C
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362

Query: 639 VK----GECHCSTGWGGVNCETPLPVC-QEQCSGHGTFL--LDAGVCSCDPKWTGSDCST 691
            +     ECHC +GW G  C   +  C    C+  GT +  +D   C C  +W G+ C  
Sbjct: 363 HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQL 422

Query: 692 EL--CTMECGSHGVCSRGI----CQCEEGWVGPTCE---ERSCHSHCTEHGQCKD----G 738
           ++  C  +C   G C   +    C C  G+ G  CE   +    S C   G C+D     
Sbjct: 423 DVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482

Query: 739 KCECSPGWEGDHCTIAHYLDAVRDGC-PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVV 797
            C C  G+ G  C +        D C P  C    RC   +  ++C C   + G  C+V 
Sbjct: 483 HCHCPQGFSGPLCEVD------VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP 536

Query: 798 ME 799
            E
Sbjct: 537 RE 538



 Score =  112 bits (281), Expect = 4e-24
 Identities = 111/375 (29%), Positives = 137/375 (36%), Gaps = 66/375 (17%)

Query: 519 FVLTTAIEIMDDC-STNCNGNGECISG----HCHCFPGFLGPDC---ARDSCPVLCGGNG 570
           F  T   E +DDC    C   G CI       C C  G+ G  C     D  P  C   G
Sbjct: 590 FTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 649

Query: 571 E----YEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMG----VCICVPGYKGEIC 622
                    +C C  GWKG  C   E QC   TC   GTC        C C PG+KG  C
Sbjct: 650 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 709

Query: 623 ---EEEDCLDPMCSNHGICVKG----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDA 675
              +   CL   C N G CV       C C  GW G  C      C      +G   +D 
Sbjct: 710 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD- 768

Query: 676 GV----CSCDPKWTGSDCS---TELCTMECGSHGVCSRGI----CQCEEGWVGPTCEE-- 722
           GV    C C P + G DC     E  +  C     C   I    C C  G  GP C+E  
Sbjct: 769 GVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828

Query: 723 ---RSCHSHCT--EHG----------QCKDGKCECSPGWEG-DHCTIAHYLDAVRDGCPG 766
              RSC S  T   HG          +C DG+ +CS  W G   C +A   +A+   CP 
Sbjct: 829 GFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP- 887

Query: 767 LCFGNGRCTLDQNGWHCV---CQVGWSGTGCNVVMEMLC---GDNLDNDGDGLTDCVDPD 820
                G+  L++    C+   C+  W   G        C     +LDN+   LT   + D
Sbjct: 888 ----LGQRCLEKAPGQCLRPPCE-AWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRD 942

Query: 821 CCQQSNCYISPLCQG 835
              Q    +  +C G
Sbjct: 943 HVPQGTT-VGAICSG 956



 Score =  111 bits (277), Expect = 1e-23
 Identities = 103/412 (25%), Positives = 143/412 (34%), Gaps = 114/412 (27%)

Query: 535 CNGNGECISGH-----CHCFPGFLGPDC--ARDSC---PVLCGGN-GEYEKG-HCVCRHG 582
           C   G CI+       C C  G+ G +C  A  +C   P   GG+  E   G  C C  G
Sbjct: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSG 376

Query: 583 WKGPECDVPEEQCIDPTCFGHGTCIMGV-------------------------------- 610
           W GP C +  ++C    C   GTC+  V                                
Sbjct: 377 WSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGT 436

Query: 611 ---------CICVPGYKGEIC--EEEDCLDPMCSNHGICVK----GECHCSTGWGGVNCE 655
                    C+C  G+ G  C  E ++C    C + G+C        CHC  G+ G  CE
Sbjct: 437 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 496

Query: 656 TPLPVCQEQCSGHGT--FLLDAG-VCSCDPKWTGSDCST--ELC---------------- 694
             + +C+     +G   + L+    C+C   + G +CS   E C                
Sbjct: 497 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG 556

Query: 695 --------TMECGSHGVC-----SRGICQCEEGWVGPTCEER--SCHSH-CTEHGQCKDG 738
                   +  CG HG C         C C+ G+ G  C E    C    C   G C D 
Sbjct: 557 PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE 616

Query: 739 ----KCECSPGWEGDHCTIAHYLDAVRDGC-PGLCFGNGRCTLDQNGWHCVCQVGWSGTG 793
               +C C  GWEG+ C      D   + C P  C   GRC    N ++C C  GW G  
Sbjct: 617 VDAFRCFCPSGWEGELC------DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKT 670

Query: 794 CNVVMEMLCGDNLDNDGDGLTD------CVDPDCCQQSNCYISPLCQGSPDP 839
           C+   E  C     ++G    D      C  P   + S C ++      P+P
Sbjct: 671 CH-SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP 721



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 55/213 (25%), Positives = 76/213 (35%), Gaps = 41/213 (19%)

Query: 661 CQEQCSGHGTFLLDA-GVCSCDPKWTGSDCSTELCTMECGS-HGVCS-RGICQCEEGWVG 717
           C+ +    G +  D  G  +C   W G +C   +C   C   HG C+  G C+C  GW G
Sbjct: 211 CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQG 270

Query: 718 PTCEERSCHSHCTEHGQC-KDGKCECSPGWEG-------DHCTIAHYL-----------D 758
             C+E   +  C  HG C +  +C C   W G       ++C   H             D
Sbjct: 271 RFCDECVPYPGCV-HGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329

Query: 759 AVRDGCP-----------------GLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEML 801
             R  CP                   C   G C    +G+ C C  GWSG  C + ++  
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE- 388

Query: 802 CGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
           C  N    G    D VD   C     ++   CQ
Sbjct: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQ 421


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  118 bits (296), Expect = 7e-26
 Identities = 94/340 (27%), Positives = 131/340 (38%), Gaps = 65/340 (19%)

Query: 529 DDCSTNCNGNGECIS-------GHCHCFPGFLGPDCARDSCPVLCGGNGEY--EKGHCVC 579
           D+CS  C    +          G+  C PG+ G  C +  C   C     Y  +   C+C
Sbjct: 182 DNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLC 241

Query: 580 RHGWKGPECDVPEEQCIDPTCFGHGTCIMG-VCICVPGYKGEICEEEDCLDPMCSNHGIC 638
           R GW+G  C+    +CI      HGTC     C C  G+ G  C+++      C++H  C
Sbjct: 242 RPGWQGRLCN----ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDL---NYCTHHSPC 294

Query: 639 VKGE-----------CHCSTGWGGVNCETPLPVCQEQ-CSGHGTFL--LDAGVCSCDPKW 684
             G            C C  G+ GV+CE  L  C    C   G+     D   C C P +
Sbjct: 295 KNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGY 354

Query: 685 TGSDC--STELCT-MECGSHGVC------SRGICQCEEGWVGPTCEER--SCHSH-CTEH 732
            G  C  ST  C    C + G C      +   C+C   + G  CE++   C S+ C   
Sbjct: 355 YGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANG 414

Query: 733 GQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVG 788
           GQC +      C C PG+ G +C + H  D  R+ C       G C   +NG  C C  G
Sbjct: 415 GQCLNRGPSRMCRCRPGFTGTYCEL-HVSDCARNPCAH----GGTCHDLENGLMCTCPAG 469

Query: 789 WSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCY 828
           +SG  C V                +  C    C  ++ CY
Sbjct: 470 FSGRRCEV-------------RTSIDACASSPCFNRATCY 496



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 78/256 (30%), Positives = 103/256 (40%), Gaps = 31/256 (12%)

Query: 578 VCRHGWKGPECDVPEEQCIDPTCFGHGTCIM-GVCICVPGYKGEICEEEDCLDPMCSNHG 636
           +C   + G  C    ++  D   FGH  C   G   C+PG+ GE C++  CL      +G
Sbjct: 174 ICSDNYYGDNCSRLCKKRNDH--FGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG 231

Query: 637 ICVK-GECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTEL-- 693
            C K  EC C  GW G  C   +P     C  HGT       C+CD  W G  C  +L  
Sbjct: 232 YCSKPAECLCRPGWQGRLCNECIP--HNGCR-HGT-CSTPWQCTCDEGWGGLFCDQDLNY 287

Query: 694 CT--MECGSHGVCSRG-----ICQCEEGWVGPTCEER--SCHSH-CTEHGQCKDGK---- 739
           CT    C +   CS        C C  G+ G  CE     C S+ C   G CKD +    
Sbjct: 288 CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYH 347

Query: 740 CECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNG--WHCVCQVGWSGTGCNVV 797
           C C PG+ G HC   H   +  D     CF  G C     G  + C C   ++G+ C   
Sbjct: 348 CLCPPGYYGLHC--EHSTLSCAD---SPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402

Query: 798 MEMLCGDNLDNDGDGL 813
           ++    +   N G  L
Sbjct: 403 VDRCTSNPCANGGQCL 418



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 64/220 (29%), Positives = 88/220 (40%), Gaps = 34/220 (15%)

Query: 535 CNGNGECISGHCHCFPGFLGPDCAR-----DSCPVLCGGN-GEYEKG-HCVCRHGWKGPE 587
           C+ +G+  S  C C PG+ G DC       DS P   GG+  + E G HC+C  G+ G  
Sbjct: 300 CSNSGQR-SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLH 358

Query: 588 CDVPEEQCIDPTCFGHGTC------IMGVCICVPGYKGEICEE--EDCLDPMCSNHGICV 639
           C+     C D  CF  G+C          C C P + G  CE+  + C    C+N G C+
Sbjct: 359 CEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418

Query: 640 ----KGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG---VCSCDPKWTGSDCSTE 692
                  C C  G+ G  CE  +  C      HG    D     +C+C   ++G  C   
Sbjct: 419 NRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVR 478

Query: 693 LCTMECGSHGVCSRG-----------ICQCEEGWVGPTCE 721
                C S    +R            +C C  G+VG  CE
Sbjct: 479 TSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score = 76.3 bits (186), Expect = 4e-13
 Identities = 60/233 (25%), Positives = 88/233 (37%), Gaps = 53/233 (22%)

Query: 645 CSTGWGGVNCETPLPVCQEQCSGHGTFLLDA-GVCSCDPKWTGSDCSTELCTMECGS-HG 702
           CS  + G NC     +C+++    G ++    G  SC P WTG  C   +C   C   +G
Sbjct: 175 CSDNYYGDNCSR---LCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG 231

Query: 703 VCSRGI-CQCEEGWVGPTCEERSCHSHCTEHGQCKDG-KCECSPGWEG-------DHCT- 752
            CS+   C C  GW G  C E   H+ C  HG C    +C C  GW G       ++CT 
Sbjct: 232 YCSKPAECLCRPGWQGRLCNECIPHNGC-RHGTCSTPWQCTCDEGWGGLFCDQDLNYCTH 290

Query: 753 --------------IAHYLDAVRDGCPGL-------------CFGNGRCTLDQNGWHCVC 785
                            Y    R G  G+             C   G C   ++G+HC+C
Sbjct: 291 HSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLC 350

Query: 786 QVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPD 838
             G+ G  C     + C D         + C +   C++ N   +  C+  P+
Sbjct: 351 PPGYYGLHCE-HSTLSCAD---------SPCFNGGSCRERNQGANYACECPPN 393



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 41/148 (27%), Positives = 55/148 (37%), Gaps = 25/148 (16%)

Query: 534 NCNGNGECISGHCHCFPGFLGPDCAR--DSC---PVLCGGN--GEYEKGHCVCRHGWKGP 586
           +C    +  +  C C P F G +C +  D C   P   GG          C CR G+ G 
Sbjct: 376 SCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGT 435

Query: 587 ECDVPEEQCIDPTCFGHGTC------IMGVCICVPGYKGEICEE----EDCLDPMCSNHG 636
            C++    C    C   GTC      +M  C C  G+ G  CE     + C    C N  
Sbjct: 436 YCELHVSDCARNPCAHGGTCHDLENGLM--CTCPAGFSGRRCEVRTSIDACASSPCFNRA 493

Query: 637 ICVKG------ECHCSTGWGGVNCETPL 658
            C          C+C  G+ G  CE P+
Sbjct: 494 TCYTDLSTDTFVCNCPYGFVGSRCEFPV 521


>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
           [Homo sapiens]
          Length = 737

 Score =  116 bits (291), Expect = 3e-25
 Identities = 96/373 (25%), Positives = 141/373 (37%), Gaps = 61/373 (16%)

Query: 487 LTSLQETGFIEYMDQ-----GPWYLAFYNDGKKMEQVFVLTTAIEIMDDC--------ST 533
           +T LQ +G +  +++        ++ F ND      V +  T +  +  C          
Sbjct: 258 VTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDL 317

Query: 534 NCNGNGECISG------HCHCFPGFLGPDCAR-DSCP-------VLCGGNGEYEKGH--- 576
            C+G G+C +        C C   ++G  C   D+C          C    E + G    
Sbjct: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFT 377

Query: 577 CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDCLDP 630
           CVC  G+ G  C    + CI   C    TCI  +    C C  GY G  CEE  + C   
Sbjct: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASS 437

Query: 631 MCSNHGIC----VKGECHCSTGWGGVNCETPLPVCQEQCSGHGTF--LLDAGVCSCDPKW 684
            C N+G C    V   C+CS G+ G  C   +  C      HGT   +  +  C CDP +
Sbjct: 438 PCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGY 497

Query: 685 TGSDCS---TELCTMECGSHGVCSRGI----CQCEEGWVGPTCE-------ERSCHSHCT 730
            G  C     E  +  C +   C   +    C C   + G  CE         SC +  T
Sbjct: 498 HGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGAT 557

Query: 731 EHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWS 790
                 +G C C+PG+ G+ C I      + +     C   G C    NG++C C  GW 
Sbjct: 558 CDSDGLNGTCICAPGFTGEECDID-----INECDSNPCHHGGSCLDQPNGYNCHCPHGWV 612

Query: 791 GTGCNVVMEMLCG 803
           G  C + ++   G
Sbjct: 613 GANCEIHLQWKSG 625



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 45/173 (26%), Positives = 67/173 (38%), Gaps = 40/173 (23%)

Query: 696 MECGSHGVCSRG------ICQCEEGWVGPTCEE------RSCHSH--CTEHGQCKDGK-- 739
           +EC   G C+         C CEE +VG  CEE      + C ++  C +  + +DG   
Sbjct: 317 LECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNF 376

Query: 740 -CECSPGWEGDHCTIAH---YLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCN 795
            C C PG+ G+ C        LD  R+G          C    +G+ C C  G+ G+ C 
Sbjct: 377 TCVCLPGYTGELCQSKIDYCILDPCRNGAT--------CISSLSGFTCQCPEGYFGSACE 428

Query: 796 VVMEMLCGDNLDNDGDGLTDCV-----------DPDCCQQSN-CYISPLCQGS 836
             ++        N+G    D V            P C Q  + C +SP   G+
Sbjct: 429 EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGT 481



 Score = 36.6 bits (83), Expect = 0.35
 Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 9/56 (16%)

Query: 577 CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMG--------VCICVPGYKGEICEE 624
           C C  G  G  C +  + C    C  HG C           +CIC  GY+G  CE+
Sbjct: 80  CTCPAGISGANCQLVADPCASNPCH-HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134



 Score = 36.2 bits (82), Expect = 0.45
 Identities = 27/114 (23%), Positives = 35/114 (30%), Gaps = 25/114 (21%)

Query: 609 GVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGH 668
           G C   P   G +C      DP            C C  G  G NC+     C      H
Sbjct: 46  GPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH 105

Query: 669 GTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEE 722
           G                  +CS+   +   G        +C C EG+ GP CE+
Sbjct: 106 G------------------NCSSSSSSSSDGY-------LCICNEGYEGPNCEQ 134



 Score = 33.5 bits (75), Expect = 2.9
 Identities = 21/60 (35%), Positives = 24/60 (40%), Gaps = 13/60 (21%)

Query: 611 CICVPGYKGEICEEEDCLDPMCSN---HGICVKGE--------CHCSTGWGGVNCETPLP 659
           C C  G  G  C+     DP  SN   HG C            C C+ G+ G NCE  LP
Sbjct: 80  CTCPAGISGANCQL--VADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALP 137


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  116 bits (290), Expect = 3e-25
 Identities = 97/362 (26%), Positives = 134/362 (37%), Gaps = 55/362 (15%)

Query: 525 IEIMDDCSTNCNGNGECISG----HCHCFPGFLGPDC--ARDSCPVL-C--GGNGEYEKG 575
           +++ +  S  C   G C  G     C C  GF GP C  A+  C    C  GG  + E G
Sbjct: 310 LDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENG 369

Query: 576 H--CVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEEED--- 626
              CVC+ G+ G  C++  + C    C   G+C+  V    C+C   +KG  CE  D   
Sbjct: 370 SAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPV 429

Query: 627 ---CLDPMCSNHGICVKGE----CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCS 679
              CL   C N G CV  +    C C  G+ G++C   +P   E  +G      +  +C 
Sbjct: 430 PDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQ 489

Query: 680 CDPKWTGSDCSTELCTMECGSHGVCSRG----------ICQCEEGWVGPTCEERSCHSH- 728
           C   + G  C  E+  M C  +  C  G          +C C             C S  
Sbjct: 490 CPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDP 549

Query: 729 CTEHGQC----KDGKCECSPGWEGDHCTIA--HYLDAVRDGCPGLCFGNGRCTLDQNGWH 782
           C   G C        CEC  G+ G HC  A  H   +      G C   G C      +H
Sbjct: 550 CFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSS------GPCRNGGTCKEAGGEYH 603

Query: 783 CVCQVGWSGTGCNVVMEMLCGDNLDNDGD------GLTDCVDPDCCQQSNCYISPL-CQG 835
           C C   ++G  C +     C     ++G       G   C  P      +C I+P  C  
Sbjct: 604 CSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFR 663

Query: 836 SP 837
           SP
Sbjct: 664 SP 665



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 98/381 (25%), Positives = 126/381 (33%), Gaps = 84/381 (22%)

Query: 528 MDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPE 587
           +DD      G G   S      P   G  C  D C     GN  Y    C C  G+ G  
Sbjct: 255 IDDAQVRVGGCGHTTSVCLALRPCLNGGKCI-DDCVT---GNPSYT---CSCLSGFTGRR 307

Query: 588 CDVPEEQCIDPTCFGHGTCIMG-------------------------------------- 609
           C +   +C    C   GTC  G                                      
Sbjct: 308 CHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVE 367

Query: 610 ----VCICVPGYKGEICE--EEDCLDPMCSNHGICV----KGECHCSTGWGGVNCET--- 656
               VC+C  GY G  CE   +DC    C N G CV       C C+  + G+ CET   
Sbjct: 368 NGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDH 427

Query: 657 PLP-VCQEQCSGHGTFLLDAG---VCSCDPKWTGSDCSTEL-CTMECGSHGVC---SRGI 708
           P+P  C      +G   +DA    VC C   + G DC   +    EC + G C   +  +
Sbjct: 428 PVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTL 487

Query: 709 CQCEEGWVGPTCEERSCHSHCTEHGQCKDG----------KCECSPGWEGDHCTIAHYLD 758
           CQC  G+ G  CE       C  + QC DG           C C      DH   +H L 
Sbjct: 488 CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC----HTDH-NASHSLP 542

Query: 759 AVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVD 818
           +  D  P  CF  G C    + + C C  G+ G  C      LC      +G    +   
Sbjct: 543 SPCDSDP--CFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGG 600

Query: 819 PDCCQQSNCYISPLCQ-GSPD 838
              C     +    C+ G PD
Sbjct: 601 EYHCSCPYRFTGRHCEIGKPD 621



 Score = 95.9 bits (237), Expect = 5e-19
 Identities = 96/335 (28%), Positives = 122/335 (36%), Gaps = 79/335 (23%)

Query: 532 STNCNGNGECI----SGHCHCFPGFLGPDCARDSCPVLC-------GGN-----GEYEKG 575
           S  C   G C     S  C C  GF G  C + + P LC       GG      GEY   
Sbjct: 547 SDPCFNGGSCDAHDDSYTCECPRGFHGKHCEK-ARPHLCSSGPCRNGGTCKEAGGEY--- 602

Query: 576 HCVCRHGWKGPECDVPE-EQCIDPTCFGHGTCIMGV----CICVPGYKGEICE--EEDCL 628
           HC C + + G  C++ + + C    C   GTC   +    C C PG+ G  CE     C 
Sbjct: 603 HCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCF 662

Query: 629 DPMCSNHGICVKGE----CHCSTGWGG------VNCETPLPVCQEQCSGHGTFLLDAGVC 678
              C N G C   +    CHC  G+ G      V+C  P  V       +GT L    + 
Sbjct: 663 RSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALY 722

Query: 679 SCDPKWTGSDCSTELCTMECGSHGV-----------------CSRG----------ICQC 711
           +CD    G   S       C  HGV                 C  G          +C C
Sbjct: 723 ACD---RGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLC 779

Query: 712 EEGWVGPTCE-ERS-CHSH-CTEHGQCKDGK----CECSPGWEGDHCTIAHYLDAVRDGC 764
             G+ G  CE ER  C +H C   G C++      C C  G+ G HC     +DA  D  
Sbjct: 780 STGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETE--VDAC-DSS 836

Query: 765 PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVME 799
           P  C   GRC      + CVC   + G  C  V +
Sbjct: 837 P--CQHGGRCESGGGAYLCVCPESFFGYHCETVSD 869



 Score = 91.7 bits (226), Expect = 9e-18
 Identities = 95/331 (28%), Positives = 121/331 (36%), Gaps = 79/331 (23%)

Query: 531 CSTN-CNGNGECISG----HCHCFPGFLGPDCA---RDSC---PVLCGGN-----GEYEK 574
           CS+  C   G C       HC C   F G  C     DSC   P   GG      G+Y+ 
Sbjct: 584 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYK- 642

Query: 575 GHCVCRHGWKGPECDVPEEQCIDPTCFGHGTC----IMGVCICVPGYKGEICEEE-DCLD 629
             C C  G+ G  C++    C    C   GTC        C C  GY G  C+ E DC  
Sbjct: 643 --CDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGP 700

Query: 630 PMCSNHG--------ICVKGECHCSTGWG-------------GVNCETP----LPVCQEQ 664
           P    H         +       C  G+              GV  E P    +  C+ Q
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQ 760

Query: 665 CSGHGTFLLD--AG-VCSCDPKWTGSDCSTELCTMECGSHGVCSRG----------ICQC 711
              HG    D  AG +C C   + G+ C  EL   EC +H  C  G          +C+C
Sbjct: 761 PCLHGGSCQDRVAGYLCLCSTGYEGAHC--ELERDECRAH-PCRNGGSCRNLPGAYVCRC 817

Query: 712 EEGWVGPTCEER--SCHSH-CTEHGQCKDG----KCECSPGWEGDHCTIAHYLDAVRDGC 764
             G+VG  CE    +C S  C   G+C+ G     C C   + G HC      + V D C
Sbjct: 818 PAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHC------ETVSDPC 871

Query: 765 -PGLCFGNGRCTLDQNGWHCVCQVGWSGTGC 794
               C G G C        C C+VG++G  C
Sbjct: 872 FSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 51/158 (32%), Positives = 69/158 (43%), Gaps = 19/158 (12%)

Query: 555 PDCAR-DSC---PVLCGGNGEYEKGH--CVCRHGWKGPECDVPEEQCIDPTCFGHGTC-- 606
           P C   D C   P L GG+ +       C+C  G++G  C++  ++C    C   G+C  
Sbjct: 749 PQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRN 808

Query: 607 IMG--VCICVPGYKGEICEEE--DCLDPMCSNHGICVKGE----CHCSTGWGGVNCETPL 658
           + G  VC C  G+ G  CE E   C    C + G C  G     C C   + G +CET  
Sbjct: 809 LPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVS 868

Query: 659 PVC-QEQCSGHGTFLLDAG--VCSCDPKWTGSDCSTEL 693
             C    C G G  L   G   C+C   +TG DC+ EL
Sbjct: 869 DPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906



 Score = 37.0 bits (84), Expect = 0.27
 Identities = 41/144 (28%), Positives = 55/144 (38%), Gaps = 22/144 (15%)

Query: 424  HHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFD-FVKLMDGKQLVKQDSKGSDDTQHSP 482
            HHP  LK     A+   L +    + P T TQ   F +L+DG+  V     GS     + 
Sbjct: 1211 HHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSPSKAATV 1270

Query: 483  RNLILTSLQETGFIEYMDQGP----WYLAFYNDGKKMEQVFVLTTAIEIMDDCSTN-CNG 537
            R+    S Q    +E M++ P      L     G K            +  +CS N C  
Sbjct: 1271 RSQPTASAQ----LENMEEAPKRVSLALQLPEHGSK--------DIGNVPGNCSENPCQN 1318

Query: 538  NGECISG----HCHCFPGFLGPDC 557
             G C+ G     C C PGF G  C
Sbjct: 1319 GGTCVPGADAHSCDCGPGFKGRRC 1342



 Score = 33.1 bits (74), Expect = 3.9
 Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 5/42 (11%)

Query: 527 IMDDC-STNCNGNGECISGH----CHCFPGFLGPDCARDSCP 563
           + D C S+ C G G C++ +    C C  G+ G DCA++  P
Sbjct: 867 VSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFP 908



 Score = 32.3 bits (72), Expect = 6.6
 Identities = 14/33 (42%), Positives = 17/33 (51%), Gaps = 4/33 (12%)

Query: 595  CIDPTCFGHGTCIMGV----CICVPGYKGEICE 623
            C +  C   GTC+ G     C C PG+KG  CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score =  114 bits (285), Expect = 1e-24
 Identities = 81/266 (30%), Positives = 106/266 (39%), Gaps = 43/266 (16%)

Query: 557  CARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDP----TCFGHGTCIMGV-- 610
            C   +C  LC  N       CVC  G         ++  +D     TC   G CI+    
Sbjct: 4176 CLDLACEFLCLLNPS--GATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKG 4233

Query: 611  ---CICVPGYKGEICEEEDCLDPMCSNHGICV-----KGECHCSTGWGGVNCETPLPVCQ 662
               C C P Y GE CE   C +  C N G CV     +  C C+ G+ G NC     VC+
Sbjct: 4234 DLRCHCWPSYSGERCEVNHCSN-YCQNGGTCVPSVLGRPTCSCALGFTGPNCGKT--VCE 4290

Query: 663  EQCSGHGTFLLDAG---VCSCDPKWTGSDCSTELCTMECGSHGVCSRGI-----CQCEEG 714
            + C   GT ++ AG    C C P++TG  C   +C   C +   C+ G      C C   
Sbjct: 4291 DFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTR 4350

Query: 715  WVGPTCEERSC----HSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFG 770
            + GP CE   C      HC  +   +D  C C+ G     C +          C G C+ 
Sbjct: 4351 YEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQL----------CDGYCYN 4400

Query: 771  NGRCTLDQ--NGWHCVCQVGWSGTGC 794
             G C LD   N   C+C   WSGT C
Sbjct: 4401 GGTCQLDPETNVPVCLCSTNWSGTQC 4426



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 65/232 (28%), Positives = 85/232 (36%), Gaps = 36/232 (15%)

Query: 529  DDCSTNCNGNGECISGH-----CHCFPGFLGPDCARDSCPVLCGGNGE-----YEKGHCV 578
            D C   C   G CI        CHC+P + G  C  + C   C   G        +  C 
Sbjct: 4215 DSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCS 4274

Query: 579  CRHGWKGPECDVPEEQCIDPTCFGHGTCIMGV-----CICVPGYKGEICEEEDCLDPMCS 633
            C  G+ GP C    +   +  C   GTCI+       C C P Y G+ C+   C    C 
Sbjct: 4275 CALGFTGPNCG---KTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVC-HHYCV 4330

Query: 634  NHGICVKG-----ECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAG--VCSCDPKWTG 686
            N   C  G     EC C T + G  CE  +  C     GH     D+    C+C      
Sbjct: 4331 NSESCTIGDDGSVECVCPTRYEGPKCE--VDKCVRCHGGHCIINKDSEDIFCNCTNGKIA 4388

Query: 687  SDCSTELCTMECGSHGVCSRG------ICQCEEGWVGPTCEERSCHSHCTEH 732
            S C  +LC   C + G C         +C C   W G  CE  +  S  ++H
Sbjct: 4389 SSC--QLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDH 4438



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 54/202 (26%), Positives = 75/202 (37%), Gaps = 33/202 (16%)

Query: 661  CQEQCSGHGTFLLDAGV---CSCDPKWTGSDCSTELCTMECGSHGVC-----SRGICQCE 712
            C+  C   G  +L+      C C P ++G  C    C+  C + G C      R  C C 
Sbjct: 4217 CKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCA 4276

Query: 713  EGWVGPTCEERSCHSHCTEHGQC-----KDGKCECSPGWEGDHCTIAHYLDAVRDGCPGL 767
             G+ GP C +  C   C   G C         C C P + GD C   +Y+      C   
Sbjct: 4277 LGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC--QYYV------CHHY 4328

Query: 768  CFGNGRCTL-DQNGWHCVCQVGWSGTGCNVVMEMLCGD-----NLDNDGDGLTDCVD--- 818
            C  +  CT+ D     CVC   + G  C V   + C       N D++ D   +C +   
Sbjct: 4329 CVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSE-DIFCNCTNGKI 4387

Query: 819  PDCCQ--QSNCYISPLCQGSPD 838
               CQ     CY    CQ  P+
Sbjct: 4388 ASSCQLCDGYCYNGGTCQLDPE 4409



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 47/184 (25%), Positives = 72/184 (39%), Gaps = 29/184 (15%)

Query: 528  MDDCSTNCNGNGECISG-----HCHCFPGFLGPDCARDSCPVLCGGNGEY-----EKGHC 577
            ++ CS  C   G C+        C C  GF GP+C +  C   C   G        + +C
Sbjct: 4250 VNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYC 4309

Query: 578  VCRHGWKGPECD--VPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNH 635
             C+  + G  C   V    C++      G      C+C   Y+G  CE + C+     + 
Sbjct: 4310 HCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVR---CHG 4366

Query: 636  GICVKGE------CHCSTGWGGVNCETPLPVCQEQCSGHGTFLLD----AGVCSCDPKWT 685
            G C+  +      C+C+ G    +C+    +C   C   GT  LD      VC C   W+
Sbjct: 4367 GHCIINKDSEDIFCNCTNGKIASSCQ----LCDGYCYNGGTCQLDPETNVPVCLCSTNWS 4422

Query: 686  GSDC 689
            G+ C
Sbjct: 4423 GTQC 4426



 Score = 39.7 bits (91), Expect = 0.041
 Identities = 65/259 (25%), Positives = 92/259 (35%), Gaps = 63/259 (24%)

Query: 535  CNGNGECI------SGHCHCFPGFLGPDCARDSCPVLCGGNGEYEK----GHCVCRHGW- 583
            C  N +CI      +G   C       DC  +SC      + +Y +     HC+ +  W 
Sbjct: 3403 CTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC------SPDYFQCKTTKHCISKL-WV 3455

Query: 584  --KGPEC-DVPEE-QCIDPTCFGHG-TCIMGVCI-----------CVPGYKGEICEEEDC 627
              + P+C D  +E  C   TC  H   C    CI           C      E C+ + C
Sbjct: 3456 CDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC 3515

Query: 628  L--DPMCSNHGICVK------GECHCSTGWGGVNCETPLPVCQEQCS------------G 667
               D +C+N G CV       G+  C+ G    NCET     Q +CS            G
Sbjct: 3516 TLKDFLCAN-GDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDG 3574

Query: 668  HGTFLLDAGVCSCDPKWTGSDCSTELCTME-CGSHGVCSRGICQCEEGWVGPTCEERSCH 726
            H          SC+P          +C  + C S  +   G   C +G      +E  C 
Sbjct: 3575 HEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADG-----SDEMDCV 3629

Query: 727  SHCTE-HGQCKDGKCECSP 744
            + C E   +CK+ K  C P
Sbjct: 3630 TECKEDQFRCKN-KAHCIP 3647



 Score = 39.7 bits (91), Expect = 0.041
 Identities = 60/251 (23%), Positives = 79/251 (31%), Gaps = 60/251 (23%)

Query: 538  NGECISGHCHCFPGFLGPDCARDS----CPVLCG------GNGEYEK------GHCVCRH 581
            NG+C+S    C   F   DCA  S    C   C        NG+         GH  C++
Sbjct: 3524 NGDCVSSRFWCDGDF---DCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKY 3580

Query: 582  GWK-------GPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPM-CS 633
            G          P C   E  C    C        G   C  G     C  E   D   C 
Sbjct: 3581 GEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK 3640

Query: 634  NHGICVK------GECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCS-----CDP 682
            N   C+       G   C  G    NCE    +C+        FL +  +C      CD 
Sbjct: 3641 NKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRAD-----EFLCNNSLCKLHFWVCDG 3695

Query: 683  KWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSH--CTEHGQCKDGKC 740
            +    D S E   M       C + +C        P+     C ++  C +  Q  +G  
Sbjct: 3696 EDDCGDNSDEAPDM-------CVKFLC--------PSTRPHRCRNNRICLQSEQMCNGID 3740

Query: 741  ECSPGWEGDHC 751
            EC    + DHC
Sbjct: 3741 ECGDNSDEDHC 3751



 Score = 38.9 bits (89), Expect = 0.070
 Identities = 72/327 (22%), Positives = 106/327 (32%), Gaps = 65/327 (19%)

Query: 557  CARDSCPVLCGG---------NGEYEKGHCVCRHGWKGPECDVPEEQCI--DPTC----- 600
            C    C +L GG         NG     +C CR    G    + + +C+  + +C     
Sbjct: 2463 CELSPCALLNGGCHDLCLLTPNGRV---NCSCR----GDRILLEDNRCVTKNSSCNAYSE 2515

Query: 601  --FGHGTCIMGVCIC--VPGYKGE------ICEEEDC-------LDPMCSNHGICVKGEC 643
               G+G CI     C  +P  K +       CE   C        +  C  HG    GE 
Sbjct: 2516 FECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGEN 2575

Query: 644  HCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCS----CDPKWTGSDCSTELCTMECG 699
             C      ++C+       E     GT +  +  C+    C       +C+   CT    
Sbjct: 2576 DCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCT-HFY 2634

Query: 700  SHGVCSRGICQCEEG--WVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYL 757
              GV + G  +C      V PT         C     C D   E     +  H    +Y 
Sbjct: 2635 KLGVKTTGFIRCNSTSLCVLPTWI-------CDGSNDCGDYSDELKCPVQNKHKCEENYF 2687

Query: 758  DAVRDGC---PGLCFGNGRCTLDQNGWHCVCQVGWSGTGCN----VVMEMLCGDNLDNDG 810
                  C     +C G   C   ++ +HC     W+   C+    +    +C D  D+ G
Sbjct: 2688 SCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWIC-DGEDDCG 2746

Query: 811  DGLTDCVDPDCCQQSNCYISPL-CQGS 836
            DGL +      C    C      CQGS
Sbjct: 2747 DGLDE--SDSICGAITCAADMFSCQGS 2771



 Score = 37.4 bits (85), Expect = 0.20
 Identities = 59/251 (23%), Positives = 81/251 (32%), Gaps = 55/251 (21%)

Query: 565  LCGGNGEYEKG----HCVCRHGWKGPECDVPEEQCIDP--TCFGHGTC---------IMG 609
            +C G  + E G    HC     W    C    ++CI     C G   C         I G
Sbjct: 2700 ICDGQKDCEDGRDEFHCDSSCSWNQFACSA--QKCISKHWICDGEDDCGDGLDESDSICG 2757

Query: 610  VCICVPGYKGEICEEEDCLDP---MCSNHGICVKGECHCSTGWGGVN--CETPLPVCQEQ 664
               C        C+      P   +C     C  G    ST     N  C+    +C  +
Sbjct: 2758 AITCAADMFS--CQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNK 2815

Query: 665  CSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGV-CSRGIC------QCE----- 712
                  F+ D      D    GSD S +    +CG+    C+ G C      QC+     
Sbjct: 2816 VCIPKQFVCDHD----DDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC 2871

Query: 713  -----EGWVGPTCE--ERSCHS--------HCTEHGQCKDGKCECSPGWEGDHCTIAHYL 757
                 E  + P C+  E+SC+S         C   G   D K +C  G +  +C I   L
Sbjct: 2872 PDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECL 2931

Query: 758  DAVRDGCPGLC 768
                 GC   C
Sbjct: 2932 SKKVSGCSQDC 2942


>gi|33598931 scavenger receptor class F, member 1 isoform 3
           precursor [Homo sapiens]
          Length = 569

 Score =  113 bits (283), Expect = 2e-24
 Identities = 91/330 (27%), Positives = 120/330 (36%), Gaps = 51/330 (15%)

Query: 535 CNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPE 592
           C  +G C   +G CHC PG+    C R           E   G CVC+ GW G  C    
Sbjct: 135 CGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSF-- 192

Query: 593 EQCIDPTCFGHGTCI---MGVCICVPGYKGEICEEE-DCLDPMCSNHGICVKGECHCSTG 648
                  C  HG+      G C C PG+ G  C+++ +C+   CS       GEC C  G
Sbjct: 193 ------RCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCS----AASGECTCPPG 242

Query: 649 WGGVNCETPLPVCQE---------QCSGHGTFLLDAGVC-SCDPKWTGSDCSTELCTMEC 698
           + G  CE P P             +C  +     D G C SC+P W G+ C         
Sbjct: 243 FRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQ------- 295

Query: 699 GSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCE-CSPGWEGDHCTIAHYL 757
                       C  G  G +CE++  H    E  +   G C+ C PGW G  C      
Sbjct: 296 -----------PCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPT 344

Query: 758 DAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEM-LCGDNLD---NDGDGL 813
               + C   C    + + D     CVC  G+ G  CN        G+N        +GL
Sbjct: 345 GTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGL 404

Query: 814 TDCVDPDCCQQSNCYISPLCQGSPDPLDLI 843
              V   C   S    + L  GS  PL L+
Sbjct: 405 CHPVSGSCQPGSGSRDTALIAGSLVPLLLL 434



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 61/210 (29%), Positives = 83/210 (39%), Gaps = 41/210 (19%)

Query: 613 CVPGYKGEICEEEDCLDPMCSNHGICVKGE-------CHCSTGWGGVNCETPL------P 659
           C  G++ +   +++C  P+C     C K E       C C  G+ G +C +        P
Sbjct: 41  CCAGWRQK---DQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGP 97

Query: 660 VCQEQ--CSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVC--SRGICQCEEGW 715
            C+E   C  HG      G C C     G+ C        CG HG C  + G+C CE GW
Sbjct: 98  DCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCA---CGPHGRCDPATGVCHCEPGW 154

Query: 716 VGPTCEERSCHSHCTEHGQCKD--GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGR 773
              TC  R C  + T   +C+   G C C PGW G  C+        R  C G       
Sbjct: 155 WSSTC-RRPCQCN-TAAARCEQATGACVCKPGWWGRRCSF-------RCNCHG------- 198

Query: 774 CTLDQNGWHCVCQVGWSGTGCNVVMEMLCG 803
              +Q+   C C+ GW G  C    E + G
Sbjct: 199 SPCEQDSGRCACRPGWWGPECQQQCECVRG 228



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 7/58 (12%)

Query: 529 DDCSTNC----NGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHG 582
           +DC + C     G+ + ++G C C  G+ GP C   SCP   G +G      C C  G
Sbjct: 349 EDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSC-NASCP--AGFHGNNCSVPCECPEG 403


>gi|33598929 scavenger receptor class F, member 1 isoform 1
           precursor [Homo sapiens]
          Length = 830

 Score =  113 bits (283), Expect = 2e-24
 Identities = 91/330 (27%), Positives = 120/330 (36%), Gaps = 51/330 (15%)

Query: 535 CNGNGEC--ISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPE 592
           C  +G C   +G CHC PG+    C R           E   G CVC+ GW G  C    
Sbjct: 135 CGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSF-- 192

Query: 593 EQCIDPTCFGHGTCI---MGVCICVPGYKGEICEEE-DCLDPMCSNHGICVKGECHCSTG 648
                  C  HG+      G C C PG+ G  C+++ +C+   CS       GEC C  G
Sbjct: 193 ------RCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCS----AASGECTCPPG 242

Query: 649 WGGVNCETPLPVCQE---------QCSGHGTFLLDAGVC-SCDPKWTGSDCSTELCTMEC 698
           + G  CE P P             +C  +     D G C SC+P W G+ C         
Sbjct: 243 FRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQ------- 295

Query: 699 GSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCE-CSPGWEGDHCTIAHYL 757
                       C  G  G +CE++  H    E  +   G C+ C PGW G  C      
Sbjct: 296 -----------PCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPT 344

Query: 758 DAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEM-LCGDNLD---NDGDGL 813
               + C   C    + + D     CVC  G+ G  CN        G+N        +GL
Sbjct: 345 GTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGL 404

Query: 814 TDCVDPDCCQQSNCYISPLCQGSPDPLDLI 843
              V   C   S    + L  GS  PL L+
Sbjct: 405 CHPVSGSCQPGSGSRDTALIAGSLVPLLLL 434



 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 61/210 (29%), Positives = 83/210 (39%), Gaps = 41/210 (19%)

Query: 613 CVPGYKGEICEEEDCLDPMCSNHGICVKGE-------CHCSTGWGGVNCETPL------P 659
           C  G++ +   +++C  P+C     C K E       C C  G+ G +C +        P
Sbjct: 41  CCAGWRQK---DQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGP 97

Query: 660 VCQEQ--CSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVC--SRGICQCEEGW 715
            C+E   C  HG      G C C     G+ C        CG HG C  + G+C CE GW
Sbjct: 98  DCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCA---CGPHGRCDPATGVCHCEPGW 154

Query: 716 VGPTCEERSCHSHCTEHGQCKD--GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGR 773
              TC  R C  + T   +C+   G C C PGW G  C+        R  C G       
Sbjct: 155 WSSTC-RRPCQCN-TAAARCEQATGACVCKPGWWGRRCSF-------RCNCHG------- 198

Query: 774 CTLDQNGWHCVCQVGWSGTGCNVVMEMLCG 803
              +Q+   C C+ GW G  C    E + G
Sbjct: 199 SPCEQDSGRCACRPGWWGPECQQQCECVRG 228



 Score = 35.0 bits (79), Expect = 1.0
 Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 7/58 (12%)

Query: 529 DDCSTNC----NGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHG 582
           +DC + C     G+ + ++G C C  G+ GP C   SCP   G +G      C C  G
Sbjct: 349 EDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSC-NASCP--AGFHGNNCSVPCECPEG 403


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  113 bits (283), Expect = 2e-24
 Identities = 88/287 (30%), Positives = 113/287 (39%), Gaps = 45/287 (15%)

Query: 578 VCRHGWKGPECDV---PEEQCIDPTCFGHGTC-IMGVCICVPGYKGEICEEEDCLDPMCS 633
           VC   + G  C V   P +       FGH TC   G  +C PG+KG  C E  CL     
Sbjct: 178 VCDEHYYGEGCSVFCRPRDDA-----FGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDE 232

Query: 634 NHGICVK-GECHCSTGWGGVNCETPL--PVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCS 690
            HG C K GEC C  GW G  C+  +  P C      HGT       C+C   W G  C+
Sbjct: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCL-----HGT-CQQPWQCNCQEGWGGLFCN 286

Query: 691 TELCTMECGSHGVCSRG-----------ICQCEEGWVGPTCE---ERSCHSHCTEHGQCK 736
            +L    C  H  C  G            C C  G+ G TCE   +    S C   G C 
Sbjct: 287 QDL--NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCT 344

Query: 737 D----GKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCT-LDQNGWHCVCQVGWSG 791
           D      C C PG+ G  C ++    A      G CF  GRC+     G+ C C VG+SG
Sbjct: 345 DLENSYSCTCPPGFYGKICELSAMTCA-----DGPCFNGGRCSDSPDGGYSCRCPVGYSG 399

Query: 792 TGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPD 838
             C   ++  C  +  ++G    D  D   C+    +    C  + D
Sbjct: 400 FNCEKKID-YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVD 445



 Score =  110 bits (276), Expect = 1e-23
 Identities = 95/336 (28%), Positives = 130/336 (38%), Gaps = 58/336 (17%)

Query: 535 CNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEY--EKGHCVCRHGWKGPECDVPE 592
           C   GE +     C PG+ GP C    C   C     +  + G C CR GW+G  CD   
Sbjct: 204 CGERGEKV-----CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD--- 255

Query: 593 EQCID-PTCFGHGTCIMG-VCICVPGYKGEICEEEDCLDPMCSNHGICVKGE-------- 642
            +CI  P C  HGTC     C C  G+ G  C ++      C++H  C  G         
Sbjct: 256 -ECIRYPGCL-HGTCQQPWQCNCQEGWGGLFCNQDL---NYCTHHKPCKNGATCTNTGQG 310

Query: 643 ---CHCSTGWGGVNCETPLPVCQEQ-CSGHG--TFLLDAGVCSCDPKWTGSDCSTELCTM 696
              C C  G+ G  CE  +  C    C   G  T L ++  C+C P + G  C  EL  M
Sbjct: 311 SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKIC--ELSAM 368

Query: 697 ECGSHGVCSRG-----------ICQCEEGWVGPTCEERSCH---SHCTEHGQCKD----G 738
            C   G C  G            C+C  G+ G  CE++  +   S C+   +C D     
Sbjct: 369 TCAD-GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAY 427

Query: 739 KCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVM 798
            C C  G+ G HC      D V D     C   G C    N + C C  G++G  C+  +
Sbjct: 428 LCRCQAGFSGRHCD-----DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPV 482

Query: 799 EMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQ 834
              C     ++G    +      C+ +  Y  P CQ
Sbjct: 483 SR-CEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517



 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 46/147 (31%), Positives = 57/147 (38%), Gaps = 22/147 (14%)

Query: 535 CNGNGECISG-----HCHCFPGFLGPDCAR--DSCPVLCGGNGEY-----EKGHCVCRHG 582
           C   G C         C C  G+ G +C +  D C      NG       +   C C+ G
Sbjct: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434

Query: 583 WKGPECDVPEEQCIDPTCFGHGTCIMGV----CICVPGYKGEICEE--EDCLDPMCSNHG 636
           + G  CD   + C    C   GTC  GV    C C PGY G  C      C    C N  
Sbjct: 435 FSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGA 494

Query: 637 IC-VKGE---CHCSTGWGGVNCETPLP 659
            C  +G    C C+ G+GG NC+  LP
Sbjct: 495 TCHERGHRYVCECARGYGGPNCQFLLP 521


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113,233,458
Number of Sequences: 37866
Number of extensions: 5792420
Number of successful extensions: 32400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 472
Number of HSP's that attempted gapping in prelim test: 21986
Number of HSP's gapped (non-prelim): 4682
length of query: 2731
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2611
effective length of database: 13,703,598
effective search space: 35780094378
effective search space used: 35780094378
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.