Guide to the Human Genome
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Search of human proteins with 251823858

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|251823858 raptor isoform 2 [Homo sapiens]
         (1177 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|251823858 raptor isoform 2 [Homo sapiens]                         2382   0.0  
gi|22094987 raptor isoform 1 [Homo sapiens]                          1360   0.0  
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    54   1e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     51   6e-06
gi|26665869 WD repeat domain 51B [Homo sapiens]                        50   1e-05
gi|148727341 serine/threonine kinase receptor associated protein...    49   2e-05
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    47   1e-04
gi|223005862 echinoderm microtubule associated protein like 6 [H...    45   3e-04
gi|34485720 echinoderm microtubule associated protein like 5 [Ho...    44   0.001
gi|89886480 zinedin isoform 2 [Homo sapiens]                           42   0.003
gi|89886477 zinedin isoform 1 [Homo sapiens]                           42   0.003
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1...    42   0.003
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog...    41   0.006
gi|16554629 WD repeat domain 5 [Homo sapiens]                          41   0.008
gi|16554627 WD repeat domain 5 [Homo sapiens]                          41   0.008
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    41   0.008
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]          40   0.010
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]          40   0.010
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        40   0.013
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [...    39   0.022
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [...    39   0.022
gi|157502169 astacin-like metalloendopeptidase [Homo sapiens]          39   0.022
gi|221219004 WD repeat domain 74 [Homo sapiens]                        39   0.029
gi|13129110 WD repeat domain 77 [Homo sapiens]                         39   0.029
gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]          38   0.065
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    38   0.065
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             37   0.11 
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             37   0.11 
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             37   0.11 
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        37   0.11 

>gi|251823858 raptor isoform 2 [Homo sapiens]
          Length = 1177

 Score = 2382 bits (6173), Expect = 0.0
 Identities = 1177/1177 (100%), Positives = 1177/1177 (100%)

Query: 1    MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV 60
            MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV
Sbjct: 1    MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV 60

Query: 61   ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK 120
            ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK
Sbjct: 61   ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK 120

Query: 121  QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY 180
            QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY
Sbjct: 121  QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY 180

Query: 181  DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC 240
            DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC
Sbjct: 181  DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC 240

Query: 241  IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG 300
            IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG
Sbjct: 241  IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG 300

Query: 301  RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY 360
            RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY
Sbjct: 301  RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY 360

Query: 361  NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL 420
            NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL
Sbjct: 361  NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL 420

Query: 421  TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL 480
            TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL
Sbjct: 421  TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL 480

Query: 481  QSSARELRPLLVFIWAKILAVDSELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPA 540
            QSSARELRPLLVFIWAKILAVDSELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPA
Sbjct: 481  QSSARELRPLLVFIWAKILAVDSELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPA 540

Query: 541  TTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGN 600
            TTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGN
Sbjct: 541  TTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGN 600

Query: 601  LSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHL 660
            LSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHL
Sbjct: 601  LSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHL 660

Query: 661  AADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSP 720
            AADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSP
Sbjct: 661  AADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSP 720

Query: 721  PASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTA 780
            PASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTA
Sbjct: 721  PASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTA 780

Query: 781  DDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRV 840
            DDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRV
Sbjct: 781  DDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRV 840

Query: 841  RRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLD 900
            RRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLD
Sbjct: 841  RRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLD 900

Query: 901  YFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDM 960
            YFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDM
Sbjct: 901  YFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDM 960

Query: 961  LPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHR 1020
            LPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHR
Sbjct: 961  LPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHR 1020

Query: 1021 SLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRI 1080
            SLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRI
Sbjct: 1021 SLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRI 1080

Query: 1081 FDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMG 1140
            FDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMG
Sbjct: 1081 FDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMG 1140

Query: 1141 QRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR 1177
            QRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR
Sbjct: 1141 QRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR 1177


>gi|22094987 raptor isoform 1 [Homo sapiens]
          Length = 1335

 Score = 1360 bits (3520), Expect = 0.0
 Identities = 675/677 (99%), Positives = 675/677 (99%)

Query: 501  VDSELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLR 560
            V  ELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLR
Sbjct: 659  VRKELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLR 718

Query: 561  SVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHI 620
            SVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHI
Sbjct: 719  SVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHI 778

Query: 621  LSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIA 680
            LSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIA
Sbjct: 779  LSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIA 838

Query: 681  YKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVS 740
            YKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVS
Sbjct: 839  YKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVS 898

Query: 741  RDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTG 800
            RDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTG
Sbjct: 899  RDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTG 958

Query: 801  FCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIF 860
            FCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIF
Sbjct: 959  FCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIF 1018

Query: 861  LNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNG 920
            LNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNG
Sbjct: 1019 LNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNG 1078

Query: 921  QDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLL 980
            QDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLL
Sbjct: 1079 QDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLL 1138

Query: 981  MSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMA 1040
            MSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMA
Sbjct: 1139 MSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMA 1198

Query: 1041 LSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTA 1100
            LSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTA
Sbjct: 1199 LSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTA 1258

Query: 1101 LDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAV 1160
            LDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAV
Sbjct: 1259 LDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAV 1318

Query: 1161 GSNDYYISVYSVEKRVR 1177
            GSNDYYISVYSVEKRVR
Sbjct: 1319 GSNDYYISVYSVEKRVR 1335



 Score = 1027 bits (2655), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV 60
           MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV
Sbjct: 1   MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSV 60

Query: 61  ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK 120
           ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK
Sbjct: 61  ALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYK 120

Query: 121 QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY 180
           QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY
Sbjct: 121 QSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIY 180

Query: 181 DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC 240
           DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC
Sbjct: 181 DLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNC 240

Query: 241 IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG 300
           IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG
Sbjct: 241 IQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG 300

Query: 301 RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY 360
           RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY
Sbjct: 301 RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSY 360

Query: 361 NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL 420
           NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL
Sbjct: 361 NCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWL 420

Query: 421 TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL 480
           TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL
Sbjct: 421 TMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLL 480

Query: 481 QSSARELRPLLVFIWAKILAVDS 503
           QSSARELRPLLVFIWAKILAVDS
Sbjct: 481 QSSARELRPLLVFIWAKILAVDS 503


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 73/319 (22%), Positives = 126/319 (39%), Gaps = 43/319 (13%)

Query: 859  IFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYL 918
            + L+ + G     KFHP    +A A  D +    W      D +         V  + Y 
Sbjct: 60   MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL-WNVYGDCDNYATLKGHSGAVMELHY- 117

Query: 919  NGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQG----LSDMLPTTRGAGMVVDWE 974
               D S+L +A+ D  + VW +     +  E V   +G    ++   P  RG  +V    
Sbjct: 118  -NTDGSMLFSASTDKTVAVWDS-----ETGERVKRLKGHTSFVNSCYPARRGPQLVC--- 168

Query: 975  QETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRV 1034
                   +  D   V++WD  ++  +Q         V +++ +     I++G  D  I+V
Sbjct: 169  -------TGSDDGTVKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKV 219

Query: 1035 YDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFD--PRMPESV--- 1089
            +D R         T R H   V   SL      +++S +++  VR++D  P  P+     
Sbjct: 220  WDLRQ---NKLTYTMRGHADSVTGLSLSSE-GSYLLSNAMDNTVRVWDVRPFAPKERCVK 275

Query: 1090 ----NVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGA 1145
                NV    K L      P    IA GS ++F  +++++   I     Y   +    G+
Sbjct: 276  IFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI----LYK--LPGHAGS 329

Query: 1146 ISCLAFHPHWPHLAVGSND 1164
            I+ +AFHP  P +   S+D
Sbjct: 330  INEVAFHPDEPIIISASSD 348


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 57/226 (25%), Positives = 104/226 (46%), Gaps = 17/226 (7%)

Query: 952  TAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCV 1011
            TAW+ L +++        +V  +    LL + GD   V +W  ++   +  + TG  S V
Sbjct: 9    TAWK-LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSL-TGHTSPV 66

Query: 1012 TSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIV- 1070
             S+  ++   LIVAG   GSIRV+D   A     +M ++ +       SL   P G  V 
Sbjct: 67   ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANI-----CSLDFHPYGEFVA 121

Query: 1071 SVSVNGDVRIFDPRMPESV-NVLQIVKGLTALDIHPQADLIACGSVNQFTAIYN-SSGEL 1128
            S S + +++++D R    V       + +  L   P    +A  + +    +++ ++G++
Sbjct: 122  SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181

Query: 1129 INNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEK 1174
            ++       F G   G ++ + FHP+   LA GS+D  I  + +EK
Sbjct: 182  MSE------FPG-HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 50/197 (25%), Positives = 83/197 (42%), Gaps = 16/197 (8%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V +     LL S+   R VR+W  D+  K  +      + V S+   +    +     D 
Sbjct: 66   VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHT-APVRSVDFSADGQFLATASEDK 124

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGH-IVSVSVNGDVRIFDPRMPESV 1089
            SI+V+   M         YR HT WV  A     PDG  IVS S +  ++I+D    + V
Sbjct: 125  SIKVWS--MYRQRFLYSLYR-HTHWVRCAKFS--PDGRLIVSCSEDKTIKIWDTTNKQCV 179

Query: 1090 NVLQIVKGLTA-LDIHPQADLIACGSVNQFTAIYNSS-GELINNIKYYDGFMGQRVGAIS 1147
            N      G    +D +P    IA    +Q   +++    +L+ + + + G        ++
Sbjct: 180  NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG-------GVN 232

Query: 1148 CLAFHPHWPHLAVGSND 1164
            C++FHP   +L   S+D
Sbjct: 233  CISFHPSGNYLITASSD 249



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 30/144 (20%), Positives = 62/144 (43%), Gaps = 20/144 (13%)

Query: 922  DCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLM 981
            D  L+++ ++D  I++W        N + V      SD +    G    VD+      + 
Sbjct: 155  DGRLIVSCSEDKTIKIWDT-----TNKQCVN---NFSDSV----GFANFVDFNPSGTCIA 202

Query: 982  SSGDVRIVRIWD--TDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRM 1039
            S+G  + V++WD   ++ ++   + +G  +C+   S     + ++    DG++++ D   
Sbjct: 203  SAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI---SFHPSGNYLITASSDGTLKILD--- 256

Query: 1040 ALSECRVMTYREHTAWVVKASLQK 1063
             L    + T + HT  V   S  K
Sbjct: 257  LLEGRLIYTLQGHTGPVFTVSFSK 280


>gi|148727341 serine/threonine kinase receptor associated protein
            [Homo sapiens]
          Length = 350

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 49/247 (19%), Positives = 103/247 (41%), Gaps = 32/247 (12%)

Query: 921  QDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLL 980
            +D +   TA  D   +VW    D     E++T            +     VD+ Q++  L
Sbjct: 69   KDATKAATAAADFTAKVW----DAVSGDELMTL---------AHKHIVKTVDFTQDSNYL 115

Query: 981  MSSGDVRIVRIWDTDR-EMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRM 1039
            ++ G  +++RI+D ++ E + ++I         +L C   + ++ A   D ++R++D   
Sbjct: 116  LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA--DDKTVRLWD-HA 172

Query: 1040 ALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLT 1099
             ++E + + +      +  +S++  P+G I+ ++    +        + +   +    + 
Sbjct: 173  TMTEVKSLNFN-----MSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATIN 227

Query: 1100 ALDIHPQADLIACG--SVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPH 1157
            +  +HP+ + +  G      +   YNS  EL    + Y G      G I C+ F P    
Sbjct: 228  SASLHPEKEFLVAGGEDFKLYKYDYNSGEEL----ESYKG----HFGPIHCVRFSPDGEL 279

Query: 1158 LAVGSND 1164
             A GS D
Sbjct: 280  YASGSED 286


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
            [Homo sapiens]
          Length = 906

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 46/193 (23%), Positives = 80/193 (41%), Gaps = 17/193 (8%)

Query: 871  VKFHPFTPCIAVADKDSIC-FWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTA 929
            +  HP  P I  +  D +   WDW+K         G+  Y        +N +D +   +A
Sbjct: 105  IAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIV---INPKDNNQFASA 161

Query: 930  TDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIV 989
            + D  I+VW+       N  +    +G++ +   + G         +   L+S  D R+V
Sbjct: 162  SLDRTIKVWQ-LGSSSPNFTLEGHEKGVNCIDYYSGG---------DKPYLISGADDRLV 211

Query: 990  RIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTY 1049
            +IWD   +  VQ +   A + V+  S      +I+ G  DG++R++       E   + Y
Sbjct: 212  KIWDYQNKTCVQTLEGHAQN-VSCASFHPELPIIITGSEDGTVRIWHSSTYRLE-STLNY 269

Query: 1050 REHTAWVVKASLQ 1062
                 W V ASL+
Sbjct: 270  GMERVWCV-ASLR 281


>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
            sapiens]
          Length = 1958

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 58/252 (23%), Positives = 103/252 (40%), Gaps = 22/252 (8%)

Query: 924  SLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSS 983
            +L  T   +G + VWK+   +     +  A  G    + TT   G++V   +E      +
Sbjct: 1567 NLTFTGAINGDVYVWKDHFLIRL---VAKAHTGPVFTMYTTLRDGLIVTGGKER----PT 1619

Query: 984  GDVRIVRIWDTD-REMKVQDIPTGA-DSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMAL 1041
             +   V++WD + +  +   + TG    CV S+     +  I+ G  DG I     + A 
Sbjct: 1620 KEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVC--RGKGKILVGTKDGEIIEVGEKNAA 1677

Query: 1042 SECRVMTYREHTAWVVKASLQKRPDGHI-VSVSVNGDVRIFDPRMPESVNVLQIVKGLTA 1100
            S   +  + E   W     L   P   + +S S +G  RI+D    + +N + +      
Sbjct: 1678 SNILIDGHMEGEIW----GLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARC 1733

Query: 1101 LDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAV 1160
                P  +++A G  N    I      L+N++K + G    R  AI  +   P    LAV
Sbjct: 1734 AAYSPDGEMVAIGMKNGEFVIL-----LVNSLKVW-GKKRDRKSAIQDIRISPDNRFLAV 1787

Query: 1161 GSNDYYISVYSV 1172
            GS+++ +  Y +
Sbjct: 1788 GSSEHTVDFYDL 1799



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 70/307 (22%), Positives = 108/307 (35%), Gaps = 57/307 (18%)

Query: 880  IAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWK 939
            + + D  SI FWDW+KGEK+        +   V      N      L+T      I+ W+
Sbjct: 790  VGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKC----NPHHVDKLVT-VGIKHIKFWQ 844

Query: 940  NFADLEKNPEMVTAWQGLSDMLPTTRGAG-----MVVDWEQETGLLMSSGDVRIVRIWDT 994
                         A  G +    T    G     M V + +   L+ S      + IW  
Sbjct: 845  Q------------AGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKD 892

Query: 995  DREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYD------------RRMALS 1042
               +K      G    + +L         V G  DG + ++D            +R ALS
Sbjct: 893  ILLLKTVKAHDGPVFAMYALD-----KGFVTGGKDGIVELWDDMFERCLKTYAIKRSALS 947

Query: 1043 ECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKG-LTAL 1101
                    E    +   +L     GHI+  + NG++   D   P ++ V   ++G +  L
Sbjct: 948  TSSKGLLLEDNPSIRAITL---GHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGL 1004

Query: 1102 DIHPQADLIACGSVNQFTAIYNSSGE----LINNIKYYDGFMGQRVGAISCLAFHPHWPH 1157
              HP   + A  S ++   I+  S +     +  +K      G R     C AF P    
Sbjct: 1005 AAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLK-----KGGR-----CCAFSPDGKA 1054

Query: 1158 LAVGSND 1164
            LAVG ND
Sbjct: 1055 LAVGLND 1061



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 32/147 (21%), Positives = 57/147 (38%), Gaps = 18/147 (12%)

Query: 925  LLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSG 984
            L +T +DD ++R+W + AD         A     +M    R      D  Q   L M  G
Sbjct: 339  LAVTGSDDRSVRLW-SLAD--------HALIARCNMEEAVRSVAFSPDGSQ-LALGMKDG 388

Query: 985  DVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY---DRRMAL 1041
               ++R+ D    + ++D        +  +      S +  G  DG + VY    R   +
Sbjct: 389  SFIVLRVRDMTEVVHIKD----RKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKI 444

Query: 1042 SEC-RVMTYREHTAWVVKASLQKRPDG 1067
             EC + +++  H  W + +   +  DG
Sbjct: 445  GECSKSLSFITHIDWSLDSKYLQTNDG 471


>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
            sapiens]
          Length = 1977

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 58/252 (23%), Positives = 106/252 (42%), Gaps = 22/252 (8%)

Query: 924  SLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSS 983
            +L  T T  G + VWK+         +  A  G    + TT   G++V   +E      S
Sbjct: 1582 NLTFTGTISGDVCVWKDHILCRI---VARAHNGPVFAMYTTLRDGLIVTGGKER----PS 1634

Query: 984  GDVRIVRIWDTD-REMKVQDIPTG-ADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMAL 1041
             +   V++WD + R  +   + TG A  CV S+ C     ++V       I V ++  A 
Sbjct: 1635 KEGGAVKLWDQELRRCRAFRLETGQATDCVRSV-CRGKGKILVGTRNAEIIEVGEKNAA- 1692

Query: 1042 SECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTAL 1101
              C ++    H    +            +S + +G VR++D    + +N + +      +
Sbjct: 1693 --CNILV-NGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTV 1749

Query: 1102 DIHPQADLIACGSVN-QFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAV 1160
               P+ D++A G  N +F  +      L++++K + G    R  AI  + F P   +LAV
Sbjct: 1750 CYSPEGDMVAIGMKNGEFIIL------LVSSLKIW-GKKRDRRCAIHDIRFSPDSRYLAV 1802

Query: 1161 GSNDYYISVYSV 1172
            GS++  +  Y +
Sbjct: 1803 GSSENSVDFYDL 1814



 Score = 37.4 bits (85), Expect = 0.085
 Identities = 74/313 (23%), Positives = 112/313 (35%), Gaps = 69/313 (22%)

Query: 880  IAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTA---------- 929
            + + D  ++  WDW+KGEKL        +   V    Y+  +    L+TA          
Sbjct: 790  VGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDK----LITAGIKHMKFWRK 845

Query: 930  TDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLL-MSSGDVRI 988
               G I        L KN  M+ A                V  W +E      S+GDV I
Sbjct: 846  AGGGLIGRKGYIGTLGKNDTMMCA----------------VYGWTEEMAFSGTSTGDVCI 889

Query: 989  VRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMT 1048
             R     + +K  D P          S  +     V G  DG + ++D   +   C + T
Sbjct: 890  WRDIFLVKTVKAHDGPV--------FSMHALEKGFVTGGKDGIVALWDD--SFERC-LKT 938

Query: 1049 YREHTAWVVKAS----LQKRPD--------GHIVSVSVNGDVRIFDPRMPESVNVLQIVK 1096
            Y    A +   S    L+  P         GHI+  + NG++   D   P ++ V   ++
Sbjct: 939  YAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHME 998

Query: 1097 G-LTALDIHPQADLIACGSVNQFTAIYNSSGE----LINNIKYYDGFMGQRVGAISCLAF 1151
            G +  L  HP   + A  S ++   I++ S       +  +K      G R     C  F
Sbjct: 999  GEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLK-----KGGR-----CCCF 1048

Query: 1152 HPHWPHLAVGSND 1164
             P    LAVG ND
Sbjct: 1049 SPDGKALAVGLND 1061


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 65/291 (22%), Positives = 119/291 (40%), Gaps = 41/291 (14%)

Query: 909  YTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLS-DMLP----- 962
            Y  + ++ + + Q  S LLTA++DG +++W    +L+K    VTA +  + D+ P     
Sbjct: 445  YDGIRSLAFHHSQ--SALLTASEDGTLKLW----NLQK---AVTAKKNAALDVEPIHAFR 495

Query: 963  TTRGAGMVVDWEQETGLLMSSGDVRIVRIWDT-DREMKVQD---------IPTGADSCVT 1012
              RG  + V     +    S G    +  W   D  M   D         +  G    V 
Sbjct: 496  AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 555

Query: 1013 SLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVM--TYREHTAWVVKASLQKRPDGHIV 1070
             L+       + +   DG++R++D   +   C     T  EH      A     P  HIV
Sbjct: 556  GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIV 614

Query: 1071 SVSVNGDVRIFDPRMPESVNVLQI--VKGLTALD---IHPQADL-IACGSVNQFTAIYNS 1124
            +   +GD  ++D  +  ++  L+     G T ++    HP   L I          + N 
Sbjct: 615  ASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNR 674

Query: 1125 SGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKR 1175
            +G+ +++       M   + A++CLA  P+   L  GS+D  + ++S++ +
Sbjct: 675  TGKPVHS-------MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 718


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 65/291 (22%), Positives = 119/291 (40%), Gaps = 41/291 (14%)

Query: 909  YTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLS-DMLP----- 962
            Y  + ++ + + Q  S LLTA++DG +++W    +L+K    VTA +  + D+ P     
Sbjct: 438  YDGIRSLAFHHSQ--SALLTASEDGTLKLW----NLQK---AVTAKKNAALDVEPIHAFR 488

Query: 963  TTRGAGMVVDWEQETGLLMSSGDVRIVRIWDT-DREMKVQD---------IPTGADSCVT 1012
              RG  + V     +    S G    +  W   D  M   D         +  G    V 
Sbjct: 489  AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVW 548

Query: 1013 SLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVM--TYREHTAWVVKASLQKRPDGHIV 1070
             L+       + +   DG++R++D   +   C     T  EH      A     P  HIV
Sbjct: 549  GLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEP-AHIV 607

Query: 1071 SVSVNGDVRIFDPRMPESVNVLQI--VKGLTALD---IHPQADL-IACGSVNQFTAIYNS 1124
            +   +GD  ++D  +  ++  L+     G T ++    HP   L I          + N 
Sbjct: 608  ASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNR 667

Query: 1125 SGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKR 1175
            +G+ +++       M   + A++CLA  P+   L  GS+D  + ++S++ +
Sbjct: 668  TGKPVHS-------MVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK 711


>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
            [Homo sapiens]
          Length = 1129

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 65/277 (23%), Positives = 117/277 (42%), Gaps = 66/277 (23%)

Query: 924  SLLLTATDDGAIRVWKNFADLE---------------KNPEMVTAW-----------QGL 957
            S ++T   DG +R+W++  D +               K+ ++VTA            +G+
Sbjct: 26   SFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGV 85

Query: 958  SDMLPT--TRGAGMVVDWEQETGLLMSSGD--VRIVRIWDTDREMKVQDIPTGADSCVTS 1013
             D + T  T  A  VV     T +   S D  V+IV + D+ ++   +    G D+ V S
Sbjct: 86   PDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFR----GHDAPVLS 141

Query: 1014 LSCDSHRSLIVAGLGDGSIRVY---DRRMALS-----ECRVMTYRE---HTAWVVKASLQ 1062
            LS D     + +   DGS+RV+   D+  A+S     +C  +   +     AW  K+   
Sbjct: 142  LSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKS--- 198

Query: 1063 KRPDGHIVSVSVNGDVRIF-----DPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQ 1117
                G ++++ V   V+++       +   S N   I + L  +   P    +A GS+N 
Sbjct: 199  ----GKLLAIPVEKSVKLYRRESWSHQFDLSDNF--ISQTLNIVTWSPCGQYLAAGSING 252

Query: 1118 FTAIYN-SSGELINNIKYYDGFMGQRVGAISCLAFHP 1153
               ++N  + + +  +K+  G+      AI  LA+HP
Sbjct: 253  LIIVWNVETKDCMERVKHEKGY------AICGLAWHP 283


>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
            [Homo sapiens]
          Length = 518

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 38/201 (18%), Positives = 92/201 (45%), Gaps = 14/201 (6%)

Query: 973  WEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSI 1032
            + Q+  LL++  +   V+++D      ++    G    V ++   + +  +V+G  D ++
Sbjct: 88   FRQDGRLLVAGSEDGGVQLFDISGRAPLRQFE-GHTKAVHTVDFTADKYHVVSGADDYTV 146

Query: 1033 RVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVL 1092
            +++D     +   ++T++EH+ +V      K      ++ S +  V++FD R  ESV  +
Sbjct: 147  KLWD---IPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSV 203

Query: 1093 QIVKGLTALDIHPQADLIACGSVNQFTAIYN--SSGELINNIKYYDGFMGQRVGAISCLA 1150
            +  + + ++ + P   L+      ++  +++    G+L+ ++K +          ++CL 
Sbjct: 204  EHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHH-------KTVTCLC 255

Query: 1151 FHPHWPHLAVGSNDYYISVYS 1171
                   L  GS D  + VYS
Sbjct: 256  LSSSGQRLLSGSLDRKVKVYS 276


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 5/122 (4%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V W  ++ LL+S+ D + ++IWD      ++ +  G  + V   + +   +LIV+G  D 
Sbjct: 93   VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN 1090
            S+R++D  +   +C + T   H+   V A    R    IVS S +G  RI+D    + + 
Sbjct: 152  SVRIWD--VKTGKC-LKTLPAHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 1091 VL 1092
             L
Sbjct: 208  TL 209



 Score = 37.7 bits (86), Expect = 0.065
 Identities = 29/115 (25%), Positives = 58/115 (50%), Gaps = 13/115 (11%)

Query: 922  DCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLM 981
            D +LL++A+DD  +++W    D+     + T  +G S+ +          ++  ++ L++
Sbjct: 98   DSNLLVSASDDKTLKIW----DVSSGKCLKTL-KGHSNYV-------FCCNFNPQSNLIV 145

Query: 982  SSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYD 1036
            S      VRIWD      ++ +P  +D  V+++  +   SLIV+   DG  R++D
Sbjct: 146  SGSFDESVRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 49/241 (20%), Positives = 103/241 (42%), Gaps = 27/241 (11%)

Query: 880  IAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWK 939
            ++ +D  ++  WD   G+ L     G+  Y              +L+++ + D ++R+W 
Sbjct: 103  VSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFN----PQSNLIVSGSFDESVRIW- 156

Query: 940  NFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMK 999
               D++    + T        LP        V + ++  L++SS    + RIWDT     
Sbjct: 157  ---DVKTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 1000 VQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSEC-RVMTYREHTAWVVK 1058
            ++ +    +  V+ +    +   I+A   D +++++D   +  +C +  T  ++  + + 
Sbjct: 206  LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD--YSKGKCLKTYTGHKNEKYCIF 263

Query: 1059 ASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDI----HPQADLIACGS 1114
            A+        IVS S +  V I++ +  E V  LQ   G T + I    HP  ++IA  +
Sbjct: 264  ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ---GHTDVVISTACHPTENIIASAA 320

Query: 1115 V 1115
            +
Sbjct: 321  L 321


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 5/122 (4%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V W  ++ LL+S+ D + ++IWD      ++ +  G  + V   + +   +LIV+G  D 
Sbjct: 93   VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN 1090
            S+R++D  +   +C + T   H+   V A    R    IVS S +G  RI+D    + + 
Sbjct: 152  SVRIWD--VKTGKC-LKTLPAHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207

Query: 1091 VL 1092
             L
Sbjct: 208  TL 209



 Score = 37.7 bits (86), Expect = 0.065
 Identities = 29/115 (25%), Positives = 58/115 (50%), Gaps = 13/115 (11%)

Query: 922  DCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLM 981
            D +LL++A+DD  +++W    D+     + T  +G S+ +          ++  ++ L++
Sbjct: 98   DSNLLVSASDDKTLKIW----DVSSGKCLKTL-KGHSNYV-------FCCNFNPQSNLIV 145

Query: 982  SSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYD 1036
            S      VRIWD      ++ +P  +D  V+++  +   SLIV+   DG  R++D
Sbjct: 146  SGSFDESVRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 49/241 (20%), Positives = 103/241 (42%), Gaps = 27/241 (11%)

Query: 880  IAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWK 939
            ++ +D  ++  WD   G+ L     G+  Y              +L+++ + D ++R+W 
Sbjct: 103  VSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFN----PQSNLIVSGSFDESVRIW- 156

Query: 940  NFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMK 999
               D++    + T        LP        V + ++  L++SS    + RIWDT     
Sbjct: 157  ---DVKTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 1000 VQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSEC-RVMTYREHTAWVVK 1058
            ++ +    +  V+ +    +   I+A   D +++++D   +  +C +  T  ++  + + 
Sbjct: 206  LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD--YSKGKCLKTYTGHKNEKYCIF 263

Query: 1059 ASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDI----HPQADLIACGS 1114
            A+        IVS S +  V I++ +  E V  LQ   G T + I    HP  ++IA  +
Sbjct: 264  ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ---GHTDVVISTACHPTENIIASAA 320

Query: 1115 V 1115
            +
Sbjct: 321  L 321


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
            sapiens]
          Length = 504

 Score = 40.8 bits (94), Expect = 0.008
 Identities = 38/162 (23%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 1016 CDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVN 1075
            C S  + I+ G  D ++ V+D+    SE  + T + HT  V         D  + S S +
Sbjct: 230  CPSDTNKILTGGADKNVVVFDKS---SEQILATLKGHTKKVTSVVFHPSQD-LVFSASPD 285

Query: 1076 GDVRIFDPRMPESVNVLQIVKG-LTALDIHPQADLIACGSVNQFTAIYN-SSGELINNIK 1133
              +RI+       V V++  +  +T L +H   D +   S +Q+ A  +  +G ++  + 
Sbjct: 286  ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 345

Query: 1134 YYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKR 1175
              D   G    +++C  FHP       G+ D  I ++ +++R
Sbjct: 346  --DETSGC---SLTCAQFHPDGLIFGTGTMDSQIKIWDLKER 382


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score = 40.4 bits (93), Expect = 0.010
 Identities = 56/264 (21%), Positives = 117/264 (44%), Gaps = 28/264 (10%)

Query: 912  VTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMV- 970
            V A+++  G    LL T   D  +++W+ F +     E   +  G +        AG+  
Sbjct: 325  VNAVQFSPGS--RLLATGGMDRRVKLWEVFGE---KCEFKGSLSGSN--------AGITS 371

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            ++++     L+++ +    RIW  D + +++   TG    V S       + IV+G  D 
Sbjct: 372  IEFDSAGSYLLAASNDFASRIWTVD-DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDR 430

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN 1090
            +++++D R  +  C    +   +   +  + Q    GH      +  +R +D R    V 
Sbjct: 431  TLKLWDLRSKV--CIKTVFAGSSCNDIVCTEQCVMSGHF-----DKKIRFWDIRSESIVR 483

Query: 1091 VLQIVKGLTALDIHPQ-ADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGA-ISC 1148
             ++++  +TALD++P+  +L++C   +    I   +    N IK      G + G+  + 
Sbjct: 484  EMELLGKITALDLNPERTELLSCSRDDLLKVIDLRT----NAIKQTFSAPGFKCGSDWTR 539

Query: 1149 LAFHPHWPHLAVGSNDYYISVYSV 1172
            + F P   ++A GS +  + ++SV
Sbjct: 540  VVFSPDGSYVAAGSAEGSLYIWSV 563


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score = 40.4 bits (93), Expect = 0.010
 Identities = 56/264 (21%), Positives = 117/264 (44%), Gaps = 28/264 (10%)

Query: 912  VTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMV- 970
            V A+++  G    LL T   D  +++W+ F +     E   +  G +        AG+  
Sbjct: 306  VNAVQFSPGS--RLLATGGMDRRVKLWEVFGE---KCEFKGSLSGSN--------AGITS 352

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            ++++     L+++ +    RIW  D + +++   TG    V S       + IV+G  D 
Sbjct: 353  IEFDSAGSYLLAASNDFASRIWTVD-DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDR 411

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN 1090
            +++++D R  +  C    +   +   +  + Q    GH      +  +R +D R    V 
Sbjct: 412  TLKLWDLRSKV--CIKTVFAGSSCNDIVCTEQCVMSGHF-----DKKIRFWDIRSESIVR 464

Query: 1091 VLQIVKGLTALDIHPQ-ADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGA-ISC 1148
             ++++  +TALD++P+  +L++C   +    I   +    N IK      G + G+  + 
Sbjct: 465  EMELLGKITALDLNPERTELLSCSRDDLLKVIDLRT----NAIKQTFSAPGFKCGSDWTR 520

Query: 1149 LAFHPHWPHLAVGSNDYYISVYSV 1172
            + F P   ++A GS +  + ++SV
Sbjct: 521  VVFSPDGSYVAAGSAEGSLYIWSV 544


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 40.0 bits (92), Expect = 0.013
 Identities = 55/263 (20%), Positives = 104/263 (39%), Gaps = 32/263 (12%)

Query: 923  CSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDM---LPTTRGAGMVVDWEQETGL 979
            C +L T  +DG I++W+    L     ++    G  D+   L  T    ++         
Sbjct: 123  CLVLATGLNDGQIKIWEVQTGL-----LLLNLSGHQDVVRDLSFTPSGSLI--------- 168

Query: 980  LMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRM 1039
            L+S+   + +RIWD ++  K   + +G    V   S     S++ +  G+ S+ ++  R 
Sbjct: 169  LVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMR- 227

Query: 1040 ALSECRVMTYREHTAWVVKASLQKRPDGH-IVSVSVNGDVRIFDPRMPE---SVNVLQIV 1095
              S   +     H + VV       PD   +V+ S + +V ++DP   E   S++  Q+ 
Sbjct: 228  --SYTLIRKLEGHQSSVVSCDFS--PDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVD 283

Query: 1096 KGLTALDIHPQADLIACGSVNQFTAIYNSSGELIN----NIKYYDGFMGQRVGAISCLAF 1151
              +   D+H  +    C S         +   L+      +K    F     G   C  F
Sbjct: 284  PAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGL--CCTF 341

Query: 1152 HPHWPHLAVGSNDYYISVYSVEK 1174
             PH   +A G+ D ++  ++  +
Sbjct: 342  FPHGGVIATGTRDGHVQFWTAPR 364


>gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo
            sapiens]
          Length = 1233

 Score = 39.3 bits (90), Expect = 0.022
 Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 50/279 (17%)

Query: 926  LLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGD 985
            +LT+  +G I++W        +  M T    L D      G    +D+ ++  L +S GD
Sbjct: 24   ILTSLHNGVIQLW--------DYRMCT----LIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71

Query: 986  VRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECR 1045
               +++W+      +  +    D   T+     +  ++ A   D +IRV++ +     C 
Sbjct: 72   DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS-DDQTIRVWNWQSRTCVC- 129

Query: 1046 VMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN-----VLQIVKGLTA 1100
            V+T   H  +V+ A      D  +VS S++  VR++D       N     V   V+G+T 
Sbjct: 130  VLTGHNH--YVMCAQFHPTED-LVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186

Query: 1101 LDI------------------------HPQADLIACGSVNQFTAIYNSSGELINNIKYYD 1136
            +D+                        HP   LI  G+ ++   I+  +      +    
Sbjct: 187  VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246

Query: 1137 GFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKR 1175
            G        +SC  FHP    +   S D  I V+ + KR
Sbjct: 247  GHYNN----VSCAVFHPRQELILSNSEDKSIRVWDMSKR 281


>gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo
            sapiens]
          Length = 1224

 Score = 39.3 bits (90), Expect = 0.022
 Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 50/279 (17%)

Query: 926  LLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGD 985
            +LT+  +G I++W        +  M T    L D      G    +D+ ++  L +S GD
Sbjct: 24   ILTSLHNGVIQLW--------DYRMCT----LIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71

Query: 986  VRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECR 1045
               +++W+      +  +    D   T+     +  ++ A   D +IRV++ +     C 
Sbjct: 72   DYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSAS-DDQTIRVWNWQSRTCVC- 129

Query: 1046 VMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVN-----VLQIVKGLTA 1100
            V+T   H  +V+ A      D  +VS S++  VR++D       N     V   V+G+T 
Sbjct: 130  VLTGHNH--YVMCAQFHPTED-LVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITG 186

Query: 1101 LDI------------------------HPQADLIACGSVNQFTAIYNSSGELINNIKYYD 1136
            +D+                        HP   LI  G+ ++   I+  +      +    
Sbjct: 187  VDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCR 246

Query: 1137 GFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKR 1175
            G        +SC  FHP    +   S D  I V+ + KR
Sbjct: 247  GHYNN----VSCAVFHPRQELILSNSEDKSIRVWDMSKR 281


>gi|157502169 astacin-like metalloendopeptidase [Homo sapiens]
          Length = 431

 Score = 39.3 bits (90), Expect = 0.022
 Identities = 28/83 (33%), Positives = 38/83 (45%), Gaps = 4/83 (4%)

Query: 691 RVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRP-- 748
           RVL     + S P  P  +G H H  G SP  +S S   L   ++ +  S D PSG    
Sbjct: 274 RVLKLYGCSPSGPR-PRGRGSHAHSTGRSPAPASLSLQRLLEALSAESRSPD-PSGSSAG 331

Query: 749 GTTGPAGAQYTPHSHQFPRTRKM 771
           G   PAG   +PH  + P  +K+
Sbjct: 332 GQPVPAGPGESPHGWESPALKKL 354


>gi|221219004 WD repeat domain 74 [Homo sapiens]
          Length = 385

 Score = 38.9 bits (89), Expect = 0.029
 Identities = 48/223 (21%), Positives = 91/223 (40%), Gaps = 24/223 (10%)

Query: 966  GAGMVVDWEQETGLLMSSGDVRIVRIW-DTDREMK---VQDIPTGADSCVTSLSCDSHRS 1021
            G GM     Q  G L++  D  I+R+W D D++     + ++  G   C       +H  
Sbjct: 86   GEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVC-RMRQDPAHPH 144

Query: 1022 LIVAGLGDGSIRVYDRRMALSECRVMTYREHTAW------VVKASLQKRPDGH-IVSVSV 1074
            ++  G  + +++++D +    E           W      +    +Q  P    +V+ + 
Sbjct: 145  VVATGGKENALKIWDLQ-GSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTG 203

Query: 1075 NGDVRIFDPRMPESVNVLQIVKG---LTALDIHPQADLIACGSVN-QFTAIYNSSGELIN 1130
               VR++DP  P+   VL+   G   LTA+ + P  + +  G+ + Q   I    G L+ 
Sbjct: 204  YHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLL- 262

Query: 1131 NIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1173
                  G +    G++  L  HP  P LA    D  + ++ ++
Sbjct: 263  ------GCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQ 299


>gi|13129110 WD repeat domain 77 [Homo sapiens]
          Length = 342

 Score = 38.9 bits (89), Expect = 0.029
 Identities = 61/258 (23%), Positives = 109/258 (42%), Gaps = 24/258 (9%)

Query: 922  DCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLM 981
            D +LLL A+     R W     L K+P      +G       T      + W  E G+L+
Sbjct: 39   DGALLLGASSLSG-RCWAGSLWLFKDP-CAAPNEGFCSAGVQTEAGVADLTWVGERGILV 96

Query: 982  SSGDVRIVRIWDTDREMKV---QDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRR 1038
            +S D   V +W+ D    +   +      D  V+++S  S  +  V+G  D  I+V+D  
Sbjct: 97   AS-DSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD-- 153

Query: 1039 MALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQI-VKG 1097
                +  + +YR H A V   +     D   +S S +  + ++D R P+  + +     G
Sbjct: 154  -LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212

Query: 1098 L--TALDIHP-QADLIACGSVNQFTAIYN--SSGELINNIKYYDGFMGQRVGAISCLAFH 1152
               T+L  HP Q+++   G  N   ++ +  S+  ++++  +           ++ L F 
Sbjct: 213  YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ--------CVTGLVFS 264

Query: 1153 PH-WPHLAVGSNDYYISV 1169
            PH  P LA  S D  ++V
Sbjct: 265  PHSVPFLASLSEDCSLAV 282


>gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]
          Length = 676

 Score = 37.7 bits (86), Expect = 0.065
 Identities = 39/181 (21%), Positives = 77/181 (42%), Gaps = 18/181 (9%)

Query: 956  GLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLS 1015
            GL   L    G    ++W ++  LL S  D +   +WD     K+  + TG  + + S+ 
Sbjct: 38   GLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVK 97

Query: 1016 CDSHRS--LIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVS 1073
               H    +++ G  D  + V+D  + + E  +  + +HT  V + +          S +
Sbjct: 98   FLPHAGDRILITGAADSKVHVHD--LTVKE-TIHMFGDHTNRVKRIATAPMWPNTFWSAA 154

Query: 1074 VNGDVRIFDPRMPESVNVLQIVKGLT----------ALDIHPQ-ADLIACGSVNQFTAIY 1122
             +G +R +D R  E+    +++  LT           L ++PQ  + +A G+   F  +Y
Sbjct: 155  EDGLIRQYDLR--ENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNNCLAVGASGPFVRLY 212

Query: 1123 N 1123
            +
Sbjct: 213  D 213


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo
            sapiens]
          Length = 340

 Score = 37.7 bits (86), Expect = 0.065
 Identities = 65/306 (21%), Positives = 118/306 (38%), Gaps = 67/306 (21%)

Query: 911  RVTAMEYLNGQDCSLLLTATDDGAIRVWKNFAD-------LEKNPEMVTAWQ-------- 955
            ++ AM +  G D  LL++A+ DG + +W ++         L  +  M  A+         
Sbjct: 57   KIYAMHW--GYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVAC 114

Query: 956  -GLSDM------------------LPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDR 996
             GL ++                  LP   G      +  ++ ++ SSGD     +WD + 
Sbjct: 115  GGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCA-LWDIET 173

Query: 997  EMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWV 1056
              +     TG    V SLS        V+G  D S +++D R  +  CR  ++  H + +
Sbjct: 174  AQQTTTF-TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGM--CR-QSFTGHVSDI 229

Query: 1057 VKASLQKRPDGHIVSV-SVNGDVRIFDPRMPESVNVL---QIVKGLTALDIHPQADLIAC 1112
               S    P+G+  +  S +   R+FD R  + + +     I+ G+T++       L+  
Sbjct: 230  NAVSF--FPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLA 287

Query: 1113 GSVNQFTAIYNSSGELINNIKYYDGFMGQRVGA-------ISCLAFHPHWPHLAVGSNDY 1165
            G  + F            N   +D   G R G        +SCL        +A GS D 
Sbjct: 288  G-YDDF------------NCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334

Query: 1166 YISVYS 1171
            ++ +++
Sbjct: 335  FLRIWN 340


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 16/202 (7%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V++     LL S    + VRIW  + + +         +  +   C   +S + A   D 
Sbjct: 29   VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDK 87

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGH-IVSVSVNGDVRIFDPRMPESV 1089
            +++V+       +  + +  +H  WV  A     PDG  IVS S +  V+++D    E V
Sbjct: 88   TVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWDKSSRECV 142

Query: 1090 NVLQIVKG-LTALDIHPQADLIACGSVNQFTAIYN-SSGELINNIKYYDGFMGQRVGAIS 1147
            +      G +T +D HP    IA   ++    +++  +  L+ + + +         A++
Sbjct: 143  HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA-------AVN 195

Query: 1148 CLAFHPHWPHLAVGSNDYYISV 1169
             L+FHP   +L   S+D  + +
Sbjct: 196  GLSFHPSGNYLITASSDSTLKI 217


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 16/202 (7%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V++     LL S    + VRIW  + + +         +  +   C   +S + A   D 
Sbjct: 67   VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDK 125

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGH-IVSVSVNGDVRIFDPRMPESV 1089
            +++V+       +  + +  +H  WV  A     PDG  IVS S +  V+++D    E V
Sbjct: 126  TVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 1090 NVLQIVKG-LTALDIHPQADLIACGSVNQFTAIYN-SSGELINNIKYYDGFMGQRVGAIS 1147
            +      G +T +D HP    IA   ++    +++  +  L+ + + +         A++
Sbjct: 181  HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA-------AVN 233

Query: 1148 CLAFHPHWPHLAVGSNDYYISV 1169
             L+FHP   +L   S+D  + +
Sbjct: 234  GLSFHPSGNYLITASSDSTLKI 255


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 16/202 (7%)

Query: 971  VDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDG 1030
            V++     LL S    + VRIW  + + +         +  +   C   +S + A   D 
Sbjct: 67   VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDK 125

Query: 1031 SIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGH-IVSVSVNGDVRIFDPRMPESV 1089
            +++V+       +  + +  +H  WV  A     PDG  IVS S +  V+++D    E V
Sbjct: 126  TVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 1090 NVLQIVKG-LTALDIHPQADLIACGSVNQFTAIYN-SSGELINNIKYYDGFMGQRVGAIS 1147
            +      G +T +D HP    IA   ++    +++  +  L+ + + +         A++
Sbjct: 181  HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA-------AVN 233

Query: 1148 CLAFHPHWPHLAVGSNDYYISV 1169
             L+FHP   +L   S+D  + +
Sbjct: 234  GLSFHPSGNYLITASSDSTLKI 255


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 58/263 (22%), Positives = 91/263 (34%), Gaps = 24/263 (9%)

Query: 535  ALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLN-KSLQNLSLTEESGGA 593
            A P   TT G S  P           S SS G+  A  +  S    SL   S T  S   
Sbjct: 4122 AFPDSTTTSGLSQEPTT---------SHSSQGSTEATLSPGSTTASSLGQQSTTFHS--- 4169

Query: 594  VAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQI 653
               SPG+  T+     T+ S   E    +  +   +    + +S  S  G+   S   Q 
Sbjct: 4170 ---SPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTST-GLQEESTTFQS 4225

Query: 654  WRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHI 713
            W         P P  + V ++V        T ++RP     T     S     + +   +
Sbjct: 4226 WPSSSDTTPSP-PSTTAVPVEV------STTYHSRPSSTPTTHFSASSTTLGRSEESTTV 4278

Query: 714  HQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFD 773
            H + G+   +   + S T+ +  +P +  + SG   TT   G+  T    +   T     
Sbjct: 4279 HSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSP 4338

Query: 774  KGPEQTADDADDAAGHKSFISAT 796
            + P+ T   A   +   S  S T
Sbjct: 4339 RSPDTTLSPASTTSSGVSEESTT 4361



 Score = 34.7 bits (78), Expect = 0.55
 Identities = 57/263 (21%), Positives = 90/263 (34%), Gaps = 24/263 (9%)

Query: 535  ALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLN-KSLQNLSLTEESGGA 593
            A P   TT G S  P           S SS G+  A  +  S    SL   S T  S   
Sbjct: 3039 AFPDSTTTSGLSQEPTA---------SHSSQGSTEATLSPGSTTASSLGQQSTTFHS--- 3086

Query: 594  VAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQI 653
               SPG+  T+     T+ S   E    +  +   +    + +S  S  G+   S   Q 
Sbjct: 3087 ---SPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSA-GLQEESTTFQS 3142

Query: 654  WRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHI 713
            W         P P  +   ++V        T ++RP     T     S     + +   +
Sbjct: 3143 WPSSSDTTPSP-PGTTAAPVEV------STTYHSRPSSTPTTHFSASSTTLGRSEESTTV 3195

Query: 714  HQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFD 773
            H + G+   +   + S T+ +  +P +  + SG   TT   G+  T    +   T     
Sbjct: 3196 HSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSP 3255

Query: 774  KGPEQTADDADDAAGHKSFISAT 796
            + P+ T   A   +   S  S T
Sbjct: 3256 RSPDTTLSPASTTSSGVSEESTT 3278



 Score = 34.3 bits (77), Expect = 0.72
 Identities = 51/269 (18%), Positives = 92/269 (34%), Gaps = 11/269 (4%)

Query: 528  IEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLT 587
            + EE + +   P +T     T   DS  T  L    +  +    +T  +L+      S  
Sbjct: 1464 VSEESSTSHSQPGSTH---TTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSL 1520

Query: 588  EESGGAVAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFN 647
             +       SPG+  T+     T+ S   E    +  +   +    + +S  S  G+   
Sbjct: 1521 GQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSA-GLQEE 1579

Query: 648  SVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPT 707
            S   Q W         P P  +   ++V        T ++RP     T     S     +
Sbjct: 1580 STTFQSWPSSSDTTPSP-PGTTAAPVEV------STTYHSRPSSTPTTHFSASSTTLGRS 1632

Query: 708  NKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPR 767
             +   +H + G+   +   + S T+ +  +P +  + SG   TT   G+  T    +   
Sbjct: 1633 EESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKST 1692

Query: 768  TRKMFDKGPEQTADDADDAAGHKSFISAT 796
            T     + P+ T   A   +   S  S T
Sbjct: 1693 TFYSSPRSPDTTLSPASTTSSGVSEESTT 1721


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,822,192
Number of Sequences: 37866
Number of extensions: 2135161
Number of successful extensions: 8141
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 7854
Number of HSP's gapped (non-prelim): 378
length of query: 1177
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1064
effective length of database: 13,968,660
effective search space: 14862654240
effective search space used: 14862654240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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