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Search of human proteins with 24308207
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308207 leucine rich repeat containing 47 [Homo sapiens] 1147 0.0
gi|124028525 phenylalanyl-tRNA synthetase, beta subunit [Homo sa... 100 4e-21
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 95 2e-19
gi|61742786 leucine rich repeat and death domain containing prot... 89 1e-17
gi|61742784 leucine rich repeat and death domain containing prot... 89 1e-17
gi|45827729 scribble isoform b [Homo sapiens] 82 1e-15
gi|45827731 scribble isoform a [Homo sapiens] 82 1e-15
gi|61742782 leucine rich repeat and death domain containing prot... 78 2e-14
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 78 3e-14
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 74 3e-13
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 73 8e-13
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] 72 2e-12
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 72 2e-12
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 72 2e-12
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 71 2e-12
gi|194440719 chondroadherin-like [Homo sapiens] 70 4e-12
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 70 4e-12
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 70 7e-12
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 69 1e-11
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 69 1e-11
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 69 1e-11
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 69 1e-11
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 69 2e-11
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 69 2e-11
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 67 5e-11
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 67 6e-11
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 67 6e-11
gi|40217803 leucine rich repeat containing 8 family, member E [H... 66 8e-11
gi|238908508 leucine-rich repeat and death domain-containing pro... 66 1e-10
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 66 1e-10
>gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
Length = 583
Score = 1147 bits (2968), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MAAAAVSESWPELELAERERRRELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGC 60
MAAAAVSESWPELELAERERRRELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGC
Sbjct: 1 MAAAAVSESWPELELAERERRRELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGC 60
Query: 61 GSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGL 120
GSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGL
Sbjct: 61 GSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGL 120
Query: 121 GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL 180
GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL
Sbjct: 121 GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL 180
Query: 181 LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDK 240
LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDK
Sbjct: 181 LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDK 240
Query: 241 RLEKMVSGCQTRSILEYLRVGGRGGGKGKGRAEGSEKEESRRKRRERKQRREGGDGEEQD 300
RLEKMVSGCQTRSILEYLRVGGRGGGKGKGRAEGSEKEESRRKRRERKQRREGGDGEEQD
Sbjct: 241 RLEKMVSGCQTRSILEYLRVGGRGGGKGKGRAEGSEKEESRRKRRERKQRREGGDGEEQD 300
Query: 301 VGDAGRLLLRVLHVSENPVPLTVRVSPEVRDVRPYIVGAVVRGMDLQPGNALKRFLTSQT 360
VGDAGRLLLRVLHVSENPVPLTVRVSPEVRDVRPYIVGAVVRGMDLQPGNALKRFLTSQT
Sbjct: 301 VGDAGRLLLRVLHVSENPVPLTVRVSPEVRDVRPYIVGAVVRGMDLQPGNALKRFLTSQT 360
Query: 361 KLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGRKEAKAKELVRQLQLEA 420
KLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGRKEAKAKELVRQLQLEA
Sbjct: 361 KLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGRKEAKAKELVRQLQLEA 420
Query: 421 EEQRKQKKRQSVSGLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLF 480
EEQRKQKKRQSVSGLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLF
Sbjct: 421 EEQRKQKKRQSVSGLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLF 480
Query: 481 LEVTSATSLQICKDVMDALILKMAEMKKYTLENKEEGSLSDTEADAVSGQLPDPTTNPSA 540
LEVTSATSLQICKDVMDALILKMAEMKKYTLENKEEGSLSDTEADAVSGQLPDPTTNPSA
Sbjct: 481 LEVTSATSLQICKDVMDALILKMAEMKKYTLENKEEGSLSDTEADAVSGQLPDPTTNPSA 540
Query: 541 GKDGPSLLVVEQVRVVDLEGSLKVVYPSKADLATAPPHVTVVR 583
GKDGPSLLVVEQVRVVDLEGSLKVVYPSKADLATAPPHVTVVR
Sbjct: 541 GKDGPSLLVVEQVRVVDLEGSLKVVYPSKADLATAPPHVTVVR 583
>gi|124028525 phenylalanyl-tRNA synthetase, beta subunit [Homo
sapiens]
Length = 589
Score = 100 bits (249), Expect = 4e-21
Identities = 58/194 (29%), Positives = 100/194 (51%), Gaps = 18/194 (9%)
Query: 325 VSPEVRDVRPYIVGAVVRGMDLQPGNALKRFLTSQTKLHEDLCEKRTAATLATHELRAVK 384
++ E +RP+ V AV+R + + F+ Q KLH+++C KR + TH+L +
Sbjct: 110 ITEETAKIRPFAVAAVLRNIKFTK-DRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLS 168
Query: 385 GPLLYCARPPQDLKIVPLGR-KEAKAKELVRQLQLEAEEQRKQKKRQSVSGLHRYLHLLD 443
GP Y A+ P D+K PL + KE A EL+ + + + L YLH+++
Sbjct: 169 GPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTD-------------NHLKHYLHIIE 215
Query: 444 GNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLFLEVTSATSLQICKDVMDALILKM 503
YP + D++G V+S PPI N + +++ T ++F+E T T K V+D ++
Sbjct: 216 NKPLYPVIYDSNGVVLSMPPIINGDHSRITVNTRNIFIECT-GTDFTKAKIVLDIIVTMF 274
Query: 504 AEM--KKYTLENKE 515
+E ++T+E E
Sbjct: 275 SEYCENQFTVEAAE 288
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 95.1 bits (235), Expect = 2e-19
Identities = 87/237 (36%), Positives = 122/237 (51%), Gaps = 31/237 (13%)
Query: 12 ELELAERERR--RE----LLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRA 65
ELE ERR RE LLL L RA G P L L+VSG +L A
Sbjct: 31 ELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPH-------LQLLDVSG-NALTA 82
Query: 66 PGPGLAQGLPQLHSLVLRRNALG-PGLSPE-LGPLP---ALRVLDLSGNALEALPPGQGL 120
GP L L L +L+ + N LG P P+ L P +L+VL+LSGN + +P
Sbjct: 83 LGPELL-ALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVP----- 136
Query: 121 GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL 180
A L LQ+L+L GN+L+ +PA++ L+ L L GN + P EL G LP
Sbjct: 137 --ASLLELRALQTLSLGGNQLQSIPAEIENLQS-LECLYLGGNFIKEIPPEL---GNLPS 190
Query: 181 LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
L+ L DN ++ + P ++ L SL++L L NN L+ +P E+ + L+E++ RGN L
Sbjct: 191 LNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Score = 72.0 bits (175), Expect = 1e-12
Identities = 62/164 (37%), Positives = 79/164 (48%), Gaps = 22/164 (13%)
Query: 80 LVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGN 139
LV ALG G P L++LD+SGNAL AL P E L L++L N
Sbjct: 56 LVSLPRALGSGF-------PHLQLLDVSGNALTALGP-------ELLALRGLRTLLAKNN 101
Query: 140 RL---RELPADLARC--APRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLREL 194
RL LP LA+ LQ LNL+GNC PA L AL LS N L+ +
Sbjct: 102 RLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLS---LGGNQLQSI 158
Query: 195 SPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
+I +L SL+ L L N + EIP EL + P L + NK++
Sbjct: 159 PAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQ 202
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 89.0 bits (219), Expect = 1e-17
Identities = 78/197 (39%), Positives = 99/197 (50%), Gaps = 31/197 (15%)
Query: 70 LAQGLPQLHSLVL----RRNALGPGLSPELGPLPA-------LRVLDLSGNALEALPPG- 117
L Q L L SLVL RR+ LG L L LPA L LDLS N+LE LP
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 118 ---QGLG------------PAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTG 162
+GLG P LP L L ++ NRL+ LP L + LQ L+L+
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALST-LQRLDLSQ 203
Query: 163 NCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELA 222
N LD+ P E+ G L L EL A N L+ L +A L SL+ L L +N L+ +PA+LA
Sbjct: 204 NLLDTLPPEI---GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
Query: 223 DCPKLKEINFRGNKLRD 239
P L ++ R N+LRD
Sbjct: 261 RLPLLTRLDLRDNQLRD 277
Score = 80.5 bits (197), Expect = 4e-15
Identities = 74/203 (36%), Positives = 95/203 (46%), Gaps = 17/203 (8%)
Query: 35 VRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPE 94
+R A LP L L L +L++S SL P + L +L+L N L L
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLS-FNSLETL-PACVLQMRGLGALLLSHNCLSE-LPEA 166
Query: 95 LGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPR 154
LG LPAL L ++ N L+ LPP G L LQ L+LS N L LP ++
Sbjct: 167 LGALPALTFLTVTHNRLQTLPPALG-------ALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 155 LQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQL 214
L+ LNL N L S PA L L L L N L + D+A L L LDL +NQL
Sbjct: 220 LE-LNLASNRLQSLPASL---AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Query: 215 SEIPAELADCPKLKEINFRGNKL 237
++P EL D P + +GN L
Sbjct: 276 RDLPPELLDAP---FVRLQGNPL 295
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 89.0 bits (219), Expect = 1e-17
Identities = 78/197 (39%), Positives = 99/197 (50%), Gaps = 31/197 (15%)
Query: 70 LAQGLPQLHSLVL----RRNALGPGLSPELGPLPA-------LRVLDLSGNALEALPPG- 117
L Q L L SLVL RR+ LG L L LPA L LDLS N+LE LP
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 118 ---QGLG------------PAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTG 162
+GLG P LP L L ++ NRL+ LP L + LQ L+L+
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALST-LQRLDLSQ 203
Query: 163 NCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELA 222
N LD+ P E+ G L L EL A N L+ L +A L SL+ L L +N L+ +PA+LA
Sbjct: 204 NLLDTLPPEI---GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
Query: 223 DCPKLKEINFRGNKLRD 239
P L ++ R N+LRD
Sbjct: 261 RLPLLTRLDLRDNQLRD 277
Score = 80.5 bits (197), Expect = 4e-15
Identities = 74/203 (36%), Positives = 95/203 (46%), Gaps = 17/203 (8%)
Query: 35 VRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPE 94
+R A LP L L L +L++S SL P + L +L+L N L L
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLS-FNSLETL-PACVLQMRGLGALLLSHNCLSE-LPEA 166
Query: 95 LGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPR 154
LG LPAL L ++ N L+ LPP G L LQ L+LS N L LP ++
Sbjct: 167 LGALPALTFLTVTHNRLQTLPPALG-------ALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 155 LQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQL 214
L+ LNL N L S PA L L L L N L + D+A L L LDL +NQL
Sbjct: 220 LE-LNLASNRLQSLPASL---AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Query: 215 SEIPAELADCPKLKEINFRGNKL 237
++P EL D P + +GN L
Sbjct: 276 RDLPPELLDAP---FVRLQGNPL 295
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 82.0 bits (201), Expect = 1e-15
Identities = 64/170 (37%), Positives = 80/170 (47%), Gaps = 12/170 (7%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
PG L L +L LR N L L L L L LDL GN LE LP G
Sbjct: 144 PGDVGNLANLVTLELRENLL-KSLPASLSFLVKLEQLDLGGNDLEVLPDTLG-------A 195
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
LP L+ L L N+L LP +L RL L+++ N L+ PAEL G L LL++L +
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLR-RLVCLDVSENRLEELPAEL---GGLVLLTDLLLS 251
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
N LR L I L L L + N+L E+ + DC L E+ N L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301
Score = 78.6 bits (192), Expect = 2e-14
Identities = 80/233 (34%), Positives = 108/233 (46%), Gaps = 27/233 (11%)
Query: 41 QLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPA 100
+LP F L L L +S R P P +A + QL L + RN + P + + A
Sbjct: 50 ELPKPFFRLLNLRKLGLSDNEIQRLP-PEVANFM-QLVELDVSRNDI-PEIPESIKFCKA 106
Query: 101 LRVLDLSGNALEALPPG-----------------QGLGPAEPPGLPQLQSLNLSGNRLRE 143
L + D SGN L LP G Q L P + L L +L L N L+
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL-PGDVGNLANLVTLELRENLLKS 165
Query: 144 LPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLAS 203
LPA L+ +L+ L+L GN L+ P L GALP L EL N L L P++ +L
Sbjct: 166 LPASLSFLV-KLEQLDLGGNDLEVLPDTL---GALPNLRELWLDRNQLSALPPELGNLRR 221
Query: 204 LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILE 256
L LD+S N+L E+PAEL L ++ N LR RL + + SIL+
Sbjct: 222 LVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLR--RLPDGIGQLKQLSILK 272
Score = 77.0 bits (188), Expect = 4e-14
Identities = 74/213 (34%), Positives = 96/213 (45%), Gaps = 23/213 (10%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
LP L L L L++ G L P LP L L L RN L L PELG L L
Sbjct: 166 LPASLSFLVKLEQLDLGG-NDLEVL-PDTLGALPNLRELWLDRNQLS-ALPPELGNLRRL 222
Query: 102 RVLDLSGNALEALPP-------------GQGLGPAEPPGLPQLQSLNL---SGNRLRELP 145
LD+S N LE LP Q L P G+ QL+ L++ NRL E+
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVT 282
Query: 146 ADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLK 205
+ C L L LT N L + P L G L L+ L N L L P+I +L
Sbjct: 283 EAIGDCE-NLSELILTENLLMALPRSL---GKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 206 TLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
L L +N+L+ +P ELA +L ++ GN+L+
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
Score = 46.6 bits (109), Expect = 6e-05
Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 27/107 (25%)
Query: 131 LQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNC 190
L+ L L N+LRELP P + LN L +L +DN
Sbjct: 38 LEELLLDANQLRELP------KPFFRLLN---------------------LRKLGLSDNE 70
Query: 191 LRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
++ L P++A+ L LD+S N + EIP + C L+ +F GN L
Sbjct: 71 IQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/110 (27%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 148 LARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTL 207
L RC ++S++ L + P E++R L EL N LREL L +L+ L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRS--LEELLLDANQLRELPKPFFRLLNLRKL 64
Query: 208 DLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEY 257
LS+N++ +P E+A+ +L E++ N + + + + + C+ I ++
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPE--IPESIKFCKALEIADF 112
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 82.0 bits (201), Expect = 1e-15
Identities = 64/170 (37%), Positives = 80/170 (47%), Gaps = 12/170 (7%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
PG L L +L LR N L L L L L LDL GN LE LP G
Sbjct: 144 PGDVGNLANLVTLELRENLL-KSLPASLSFLVKLEQLDLGGNDLEVLPDTLG-------A 195
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
LP L+ L L N+L LP +L RL L+++ N L+ PAEL G L LL++L +
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLR-RLVCLDVSENRLEELPAEL---GGLVLLTDLLLS 251
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
N LR L I L L L + N+L E+ + DC L E+ N L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301
Score = 78.6 bits (192), Expect = 2e-14
Identities = 80/233 (34%), Positives = 108/233 (46%), Gaps = 27/233 (11%)
Query: 41 QLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPA 100
+LP F L L L +S R P P +A + QL L + RN + P + + A
Sbjct: 50 ELPKPFFRLLNLRKLGLSDNEIQRLP-PEVANFM-QLVELDVSRNDI-PEIPESIKFCKA 106
Query: 101 LRVLDLSGNALEALPPG-----------------QGLGPAEPPGLPQLQSLNLSGNRLRE 143
L + D SGN L LP G Q L P + L L +L L N L+
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL-PGDVGNLANLVTLELRENLLKS 165
Query: 144 LPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLAS 203
LPA L+ +L+ L+L GN L+ P L GALP L EL N L L P++ +L
Sbjct: 166 LPASLSFLV-KLEQLDLGGNDLEVLPDTL---GALPNLRELWLDRNQLSALPPELGNLRR 221
Query: 204 LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILE 256
L LD+S N+L E+PAEL L ++ N LR RL + + SIL+
Sbjct: 222 LVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLR--RLPDGIGQLKQLSILK 272
Score = 77.0 bits (188), Expect = 4e-14
Identities = 74/213 (34%), Positives = 96/213 (45%), Gaps = 23/213 (10%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
LP L L L L++ G L P LP L L L RN L L PELG L L
Sbjct: 166 LPASLSFLVKLEQLDLGG-NDLEVL-PDTLGALPNLRELWLDRNQLS-ALPPELGNLRRL 222
Query: 102 RVLDLSGNALEALPP-------------GQGLGPAEPPGLPQLQSLNL---SGNRLRELP 145
LD+S N LE LP Q L P G+ QL+ L++ NRL E+
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVT 282
Query: 146 ADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLK 205
+ C L L LT N L + P L G L L+ L N L L P+I +L
Sbjct: 283 EAIGDCE-NLSELILTENLLMALPRSL---GKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 206 TLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
L L +N+L+ +P ELA +L ++ GN+L+
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
Score = 46.6 bits (109), Expect = 6e-05
Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 27/107 (25%)
Query: 131 LQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNC 190
L+ L L N+LRELP P + LN L +L +DN
Sbjct: 38 LEELLLDANQLRELP------KPFFRLLN---------------------LRKLGLSDNE 70
Query: 191 LRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
++ L P++A+ L LD+S N + EIP + C L+ +F GN L
Sbjct: 71 IQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/110 (27%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 148 LARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTL 207
L RC ++S++ L + P E++R L EL N LREL L +L+ L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRS--LEELLLDANQLRELPKPFFRLLNLRKL 64
Query: 208 DLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEY 257
LS+N++ +P E+A+ +L E++ N + + + + + C+ I ++
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPE--IPESIKFCKALEIADF 112
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/161 (38%), Positives = 78/161 (48%), Gaps = 15/161 (9%)
Query: 77 LHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNL 136
L +L+L N L L LG LPAL L ++ N L+ LPP G L LQ L+L
Sbjct: 4 LGALLLSHNCLSE-LPEALGALPALTFLTVTHNRLQTLPPALG-------ALSTLQRLDL 55
Query: 137 SGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP 196
S N L LP ++ L+ LNL N L S PA L L L L N L +
Sbjct: 56 SQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASL---AGLRSLRLLVLHSNLLASVPA 111
Query: 197 DIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
D+A L L LDL +NQL ++P EL D P + +GN L
Sbjct: 112 DLARLPLLTRLDLRDNQLRDLPPELLDAP---FVRLQGNPL 149
Score = 77.0 bits (188), Expect = 4e-14
Identities = 56/139 (40%), Positives = 74/139 (53%), Gaps = 11/139 (7%)
Query: 101 LRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNL 160
L L LS N L LP G LP L L ++ NRL+ LP L + LQ L+L
Sbjct: 4 LGALLLSHNCLSELPEALG-------ALPALTFLTVTHNRLQTLPPALGALST-LQRLDL 55
Query: 161 TGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAE 220
+ N LD+ P E+ G L L EL A N L+ L +A L SL+ L L +N L+ +PA+
Sbjct: 56 SQNLLDTLPPEI---GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPAD 112
Query: 221 LADCPKLKEINFRGNKLRD 239
LA P L ++ R N+LRD
Sbjct: 113 LARLPLLTRLDLRDNQLRD 131
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 77.8 bits (190), Expect = 3e-14
Identities = 84/260 (32%), Positives = 112/260 (43%), Gaps = 42/260 (16%)
Query: 10 WPELELAERERR---RELLLTGPGLEERVRAAGGQLP--PRLFTLPLLHYLEVSGCGS-- 62
W + L R+ R R+L LT G A + P P+L L +E G+
Sbjct: 15 WRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNG 74
Query: 63 LRAPGPGLAQGLPQLHSLVLRRNALG--PGLSPELG----------------------PL 98
L GL L L LVLRRN P ELG L
Sbjct: 75 LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSAL 134
Query: 99 PALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSL 158
LR L+LS N L ALP G L L+ L++S NRL LP L+ C RL++L
Sbjct: 135 RELRKLNLSHNQLPALPAQLG-------ALAHLEELDVSFNRLAHLPDSLS-CLSRLRTL 186
Query: 159 NLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIP 218
++ N L +FP +L + L L EL + N LR L DI+ L +LK L LS +L +P
Sbjct: 187 DVDHNQLTAFPRQLLQ---LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLP 243
Query: 219 AELADCPKLKEINFRGNKLR 238
A + L+ + N L+
Sbjct: 244 AGFCELASLESLMLDNNGLQ 263
Score = 72.8 bits (177), Expect = 8e-13
Identities = 71/198 (35%), Positives = 96/198 (48%), Gaps = 18/198 (9%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
LP L L L L+V L A L Q L L L + N L GL ++ L AL
Sbjct: 173 LPDSLSCLSRLRTLDVDH-NQLTAFPRQLLQ-LVALEELDVSSNRLR-GLPEDISALRAL 229
Query: 102 RVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLT 161
++L LSG L LP G L L+SL L N L+ LPA + C RL+ LNL+
Sbjct: 230 KILWLSGAELGTLPAGFC-------ELASLESLMLDNNGLQALPAQFS-CLQRLKMLNLS 281
Query: 162 GNCLDSFPAELFRPGALPL--LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPA 219
N + FPA L LPL L EL + N L + I+ L L TL L NN++ +P
Sbjct: 282 SNLFEEFPAAL-----LPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPD 336
Query: 220 ELADCPKLKEINFRGNKL 237
+ + L+E+ +GN++
Sbjct: 337 SIVELTGLEELVLQGNQI 354
Score = 63.5 bits (153), Expect = 5e-10
Identities = 72/225 (32%), Positives = 99/225 (44%), Gaps = 25/225 (11%)
Query: 41 QLPPRLFTLPL-LHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLP 99
+LPP + L L L+VS L A G + L +L L L N L P L +LG L
Sbjct: 101 RLPPAVAELGHHLTELDVSH-NRLTALGAEVVSALRELRKLNLSHNQL-PALPAQLGALA 158
Query: 100 ALRVLDLSGNALEALPPGQGL----------------GPAEPPGLPQLQSLNLSGNRLRE 143
L LD+S N L LP P + L L+ L++S NRLR
Sbjct: 159 HLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRG 218
Query: 144 LPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLAS 203
LP D++ L+ L L+G L + PA L L L +N L+ L + L
Sbjct: 219 LPEDISALRA-LKILWLSGAELGTLPAGFCE---LASLESLMLDNNGLQALPAQFSCLQR 274
Query: 204 LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSG 248
LK L+LS+N E PA L L+E+ N+L + ++SG
Sbjct: 275 LKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTS--VPSLISG 317
Score = 59.7 bits (143), Expect = 7e-09
Identities = 63/197 (31%), Positives = 88/197 (44%), Gaps = 14/197 (7%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
LP +L L L L+VS + A P L +L +L + N L +L L AL
Sbjct: 150 LPAQLGALAHLEELDVSF--NRLAHLPDSLSCLSRLRTLDVDHNQL-TAFPRQLLQLVAL 206
Query: 102 RVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLT 161
LD+S N L LP + L L+ L LSG L LPA A L+SL L
Sbjct: 207 EELDVSSNRLRGLPE-------DISALRALKILWLSGAELGTLPAGFCELAS-LESLMLD 258
Query: 162 GNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAEL 221
N L + PA+ L L L + N E + LA L+ L LS NQL+ +P+ +
Sbjct: 259 NNGLQALPAQF---SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLI 315
Query: 222 ADCPKLKEINFRGNKLR 238
+ +L + N++R
Sbjct: 316 SGLGRLLTLWLDNNRIR 332
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 74.3 bits (181), Expect = 3e-13
Identities = 58/166 (34%), Positives = 80/166 (48%), Gaps = 14/166 (8%)
Query: 74 LPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQS 133
L + LVL N L + P + L L VL+ N +E LP + L +L+
Sbjct: 39 LSHITQLVLSHNKLTM-VPPNIAELKNLEVLNFFNNQIEELP-------TQISSLQKLKH 90
Query: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCL--DSFPAELFRPGALPLLSELAAADNCL 191
LNL NRL LP P L+ L+LT N L +S P F L L L +DN
Sbjct: 91 LNLGMNRLNTLPRGFGSL-PALEVLDLTYNNLSENSLPGNFFY---LTTLRALYLSDNDF 146
Query: 192 RELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
L PDI L L+ L L +N L +P E+ + +LKE++ +GN+L
Sbjct: 147 EILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL 192
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/221 (29%), Positives = 101/221 (45%), Gaps = 23/221 (10%)
Query: 6 VSESWPELELAERERRR-ELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLR 64
+S+S +L RE+ + E+ ++ G+ + G LFTL + L +S
Sbjct: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNG------LFTLSHITQLVLSHNKLTM 54
Query: 65 APGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAE 124
P P +A+ L L L N + L ++ L L+ L+L N L LP G G
Sbjct: 55 VP-PNIAE-LKNLEVLNFFNNQIEE-LPTQISSLQKLKHLNLGMNRLNTLPRGFG----- 106
Query: 125 PPGLPQLQSLNLSGNRLRE--LPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLS 182
LP L+ L+L+ N L E LP + L++L L+ N + P ++ G L L
Sbjct: 107 --SLPALEVLDLTYNNLSENSLPGNFFYLTT-LRALYLSDNDFEILPPDI---GKLTKLQ 160
Query: 183 ELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELAD 223
L+ DN L L +I L LK L + N+L+ +P EL +
Sbjct: 161 ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
Score = 30.4 bits (67), Expect = 4.7
Identities = 18/61 (29%), Positives = 35/61 (57%), Gaps = 5/61 (8%)
Query: 201 LASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYLRV 260
L+ + L LS+N+L+ +P +A+ L+ +NF N++ + L +S Q L++L +
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEE--LPTQISSLQK---LKHLNL 93
Query: 261 G 261
G
Sbjct: 94 G 94
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 72.8 bits (177), Expect = 8e-13
Identities = 67/199 (33%), Positives = 89/199 (44%), Gaps = 11/199 (5%)
Query: 41 QLPPRLF-TLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLP 99
QLP F P L L+++G L P GL +L L L+ N L S + L
Sbjct: 71 QLPEDAFKNFPFLEELQLAG-NDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLS 129
Query: 100 ALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLN 159
AL+ L L N + ++P GL QL+ L L N L E+P P LQ+L
Sbjct: 130 ALQSLRLDANHITSVPEDSF------EGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALT 183
Query: 160 LTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAH-LASLKTLDLSNNQLSEIP 218
L N + S P F L L L +N +R LS L +L+TLDL+ N L E P
Sbjct: 184 LALNKISSIPDFAFTN--LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP 241
Query: 219 AELADCPKLKEINFRGNKL 237
+ P LKE+ F N +
Sbjct: 242 QAIKALPSLKELGFHSNSI 260
Score = 55.5 bits (132), Expect = 1e-07
Identities = 45/142 (31%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 99 PALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSL 158
P L L L+GN L + P GL +L+ L L N+L+ +P++ R LQSL
Sbjct: 81 PFLEELQLAGNDLSFIHP------KALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSL 134
Query: 159 NLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELS-PDIAHLASLKTLDLSNNQLSEI 217
L N + S P + F L L L DN L E+ +++L +L+ L L+ N++S I
Sbjct: 135 RLDANHITSVPEDSFE--GLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI 192
Query: 218 P-AELADCPKLKEINFRGNKLR 238
P + L ++ NK+R
Sbjct: 193 PDFAFTNLSSLVVLHLHNNKIR 214
Score = 45.4 bits (106), Expect = 1e-04
Identities = 50/163 (30%), Positives = 73/163 (44%), Gaps = 25/163 (15%)
Query: 66 PGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL----RVLDLSGNALEALPPGQGLG 121
PGP GL +L L +A G +P L P R +D SG L A+P G
Sbjct: 2 PGP---LGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAF 58
Query: 122 PAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLL 181
Q+L++S N + +LP D + P L+ L L GN L P AL L
Sbjct: 59 T---------QALDISMNNITQLPEDAFKNFPFLEELQLAGNDL-----SFIHPKALSGL 104
Query: 182 SE---LAAADNCLREL-SPDIAHLASLKTLDLSNNQLSEIPAE 220
E L +N L+ + S I L++L++L L N ++ +P +
Sbjct: 105 KELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147
Score = 37.7 bits (86), Expect = 0.029
Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 36/178 (20%)
Query: 73 GLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQ 132
GL L +L L N LG + LP+L+ L N++ +P G G P L+
Sbjct: 223 GLDNLETLDLNYNNLGE-FPQAIKALPSLKELGFHSNSISVIPDGAF------DGNPLLR 275
Query: 133 SLNLSGN-----------RLRELPADLARCAPRLQSL-NLTGNC-LDSFPAELFRPGALP 179
+++L N L +L + + R A +Q NLTG L+S + ++P
Sbjct: 276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIP 335
Query: 180 LLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
+N +E L+TLDLS N + ++P+ C L+EI+ + N++
Sbjct: 336 --------NNLCQEQK-------MLRTLDLSYNNIRDLPS-FNGCHALEEISLQRNQI 377
Score = 37.0 bits (84), Expect = 0.050
Identities = 44/155 (28%), Positives = 70/155 (45%), Gaps = 12/155 (7%)
Query: 67 GPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPP 126
G L LHSLV+R ++ P L L L L+G + ++P L +
Sbjct: 288 GNSAFHNLSDLHSLVIRGASMVQQF-PNLTGTVHLESLTLTGTKISSIP--NNLCQEQK- 343
Query: 127 GLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAA 186
L++L+LS N +R+LP+ A L+ ++L N + F+ L L L
Sbjct: 344 ---MLRTLDLSYNNIRDLPSFNGCHA--LEEISLQRNQIYQIKEGTFQ--GLISLRILDL 396
Query: 187 ADNCLREL-SPDIAHLASLKTLDLSNNQLSEIPAE 220
+ N + E+ S A L + LD+S N+L+ P E
Sbjct: 397 SRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE 431
>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
Length = 347
Score = 71.6 bits (174), Expect = 2e-12
Identities = 71/196 (36%), Positives = 89/196 (45%), Gaps = 47/196 (23%)
Query: 70 LAQGLPQLHSLVLRRNALGPGLSPE-LGPLPALRVLDLSGNALEALPPG----------- 117
L QG +L L L N L LSPE L P+P LRVLDL+ NAL LPPG
Sbjct: 87 LLQGASKLQELHLSSNGL-ESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTL 145
Query: 118 -------QGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPA 170
+ L + GL L L+LSGNRLR+LP L L++L+L N L++ P
Sbjct: 146 VLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPP 205
Query: 171 ELFRPGALPLLSELAAADNCLREL-------SPDIAH------------------LASLK 205
+L R G L L L N L+ L PD+ + L L
Sbjct: 206 DLLR-GPLQ-LERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLD 263
Query: 206 TLDLSNNQLSEIPAEL 221
LDLSNN L+ +P L
Sbjct: 264 MLDLSNNSLASVPEGL 279
Score = 64.3 bits (155), Expect = 3e-10
Identities = 72/227 (31%), Positives = 101/227 (44%), Gaps = 29/227 (12%)
Query: 33 ERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLS 92
+R ++ GG P TL LL L S G +P S+ + A PG
Sbjct: 7 QRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPPAEIPGYL 66
Query: 93 P-----------ELGPLPA--------LRVLDLSGNALEALPPGQGLGPAEPPGLPQLQS 133
P L LPA L+ L LS N LE+L P + L P +PQL+
Sbjct: 67 PADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSP-EFLRP-----VPQLRV 120
Query: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRE 193
L+L+ N L LP L + + L +L L N L+ L L L + N LR+
Sbjct: 121 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLH--GLKALGHLDLSGNRLRK 178
Query: 194 LSPDI-AHLASLKTLDLSNNQLSEIPAELADCP-KLKEINFRGNKLR 238
L P + A+ L+TLDL NQL +P +L P +L+ ++ GNKL+
Sbjct: 179 LPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQ 225
Score = 45.1 bits (105), Expect = 2e-04
Identities = 58/194 (29%), Positives = 77/194 (39%), Gaps = 50/194 (25%)
Query: 22 RELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLV 81
+EL L+ GLE P L +P L L+++ +L PGL Q L +LV
Sbjct: 95 QELHLSSNGLESLS-------PEFLRPVPQLRVLDLTR-NALTGLPPGLFQASATLDTLV 146
Query: 82 LRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQ----------GLGPAE----PPG 127
L+ N L L L AL LDLSGN L LPPG LG + PP
Sbjct: 147 LKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPD 206
Query: 128 L----------------------------PQLQSLNLSGNRLRELPADLARCAPRLQSLN 159
L P L+ L L+GN+L + A + +L L+
Sbjct: 207 LLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLD 266
Query: 160 LTGNCLDSFPAELF 173
L+ N L S P L+
Sbjct: 267 LSNNSLASVPEGLW 280
Score = 34.7 bits (78), Expect = 0.25
Identities = 32/99 (32%), Positives = 42/99 (42%), Gaps = 3/99 (3%)
Query: 42 LPPRLFTLPL-LHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPA 100
LPP L PL L L + G L+ G L P L L L N L + L
Sbjct: 203 LPPDLLRGPLQLERLHLEG-NKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQ 261
Query: 101 LRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGN 139
L +LDLS N+L ++P G + P ++SGN
Sbjct: 262 LDMLDLSNNSLASVPEGLWASLGQ-PNWDMRDGFDISGN 299
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/147 (35%), Positives = 72/147 (48%), Gaps = 13/147 (8%)
Query: 93 PELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCA 152
P + L L VL+ N +E LP + L +L+ LNL NRL LP
Sbjct: 4 PNIAELKNLEVLNFFNNQIEELP-------TQISSLQKLKHLNLGMNRLNTLPRGFGSL- 55
Query: 153 PRLQSLNLTGNCL--DSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLS 210
P L+ L+LT N L +S P F L L L +DN L PDI L L+ L L
Sbjct: 56 PALEVLDLTYNNLSENSLPGNFFY---LTTLRALYLSDNDFEILPPDIGKLTKLQILSLR 112
Query: 211 NNQLSEIPAELADCPKLKEINFRGNKL 237
+N L +P E+ + +LKE++ +GN+L
Sbjct: 113 DNDLISLPKEIGELTQLKELHIQGNRL 139
Score = 52.8 bits (125), Expect = 9e-07
Identities = 44/135 (32%), Positives = 65/135 (48%), Gaps = 13/135 (9%)
Query: 91 LSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRE--LPADL 148
L ++ L L+ L+L N L LP G G LP L+ L+L+ N L E LP +
Sbjct: 25 LPTQISSLQKLKHLNLGMNRLNTLPRGFG-------SLPALEVLDLTYNNLSENSLPGNF 77
Query: 149 ARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLD 208
L++L L+ N + P ++ G L L L+ DN L L +I L LK L
Sbjct: 78 FYLTT-LRALYLSDNDFEILPPDI---GKLTKLQILSLRDNDLISLPKEIGELTQLKELH 133
Query: 209 LSNNQLSEIPAELAD 223
+ N+L+ +P EL +
Sbjct: 134 IQGNRLTVLPPELGN 148
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/192 (33%), Positives = 94/192 (48%), Gaps = 15/192 (7%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
P L L L L N L L E+ + L+ LD + N LE +PP E G
Sbjct: 190 PASFSSLSSLVRLNLSSNEL-KSLPAEINRMKRLKHLDCNSNLLETIPP-------ELAG 241
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
+ L+ L L N+LR LP + C+ L+ L++ N ++ AE + L + L
Sbjct: 242 MESLELLYLRRNKLRFLP-EFPSCS-LLKELHVGENQIEMLEAEHLKH--LNSILVLDLR 297
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVS 247
DN L+ + +I L SL+ LDLSNN +S +P L + LK + GN LR R E +
Sbjct: 298 DNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISK 356
Query: 248 GCQTRSILEYLR 259
G T+ +L+YLR
Sbjct: 357 G--TQEVLKYLR 366
Score = 67.0 bits (162), Expect = 5e-11
Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 33/184 (17%)
Query: 77 LHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNL 136
L L++ N L L+ +L LPAL VLD+ N L +LP + L LQ LN+
Sbjct: 84 LTKLIISNNKL-QSLTDDLRLLPALTVLDIHDNQLTSLP-------SAIRELENLQKLNV 135
Query: 137 SGNRLRELPADLA-----RCA-----------------PRLQSLNLTGNCLDSFPAELFR 174
S N+L+ LP ++ +C L+ L+L+ N L + PA
Sbjct: 136 SHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASF-- 193
Query: 175 PGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRG 234
+L L L + N L+ L +I + LK LD ++N L IP ELA L+ + R
Sbjct: 194 -SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRR 252
Query: 235 NKLR 238
NKLR
Sbjct: 253 NKLR 256
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/133 (34%), Positives = 70/133 (52%), Gaps = 7/133 (5%)
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L +L L+L N L LP ++ RLQ++NL+ N P L+R + L + +
Sbjct: 471 LQKLTFLDLRNNFLNSLPEEMESLV-RLQTINLSFNRFKMLPEVLYR---IFTLETILIS 526
Query: 188 DNCLRELSPD-IAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMV 246
+N + + P + + +L TLDL NN L +IP EL +C L+ + GN R R ++
Sbjct: 527 NNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM 586
Query: 247 SGCQTRSILEYLR 259
G T +ILEYLR
Sbjct: 587 KG--TAAILEYLR 597
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 14/129 (10%)
Query: 117 GQGLGPAEPPGLPQLQ----SLNLSGNRLRELPADLARC---APRLQSLNLTGNCLDSFP 169
G+ G + P GL + LNLSG L E+P + R P + NL+ + +
Sbjct: 20 GRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWW 79
Query: 170 AELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKE 229
+ L++L ++N L+ L+ D+ L +L LD+ +NQL+ +P+ + + L++
Sbjct: 80 EQTD-------LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQK 132
Query: 230 INFRGNKLR 238
+N NKL+
Sbjct: 133 LNVSHNKLK 141
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 157 SLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSE 216
S+N + N L P + ++S++ + N L +S ++ L L LDL NN L+
Sbjct: 429 SINFSKNQLCEIPKRMVE--LKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
Query: 217 IPAELADCPKLKEINFRGNKLR 238
+P E+ +L+ IN N+ +
Sbjct: 487 LPEEMESLVRLQTINLSFNRFK 508
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/172 (31%), Positives = 90/172 (52%), Gaps = 12/172 (6%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
P + L QL L L N L L E+G L L L LS N+L +LP
Sbjct: 116 PSSIKELTQLTELYLYSNKL-QSLPAEVGCLVNLMTLALSENSLTSLPDSLD-------N 167
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L +L+ L+L N+LRE+P+ + R L +L L N + + ++ L LS L+
Sbjct: 168 LKKLRMLDLRHNKLREIPSVVYRL-DSLTTLYLRFNRITTVEKDIKN---LSKLSMLSIR 223
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD 239
+N +++L +I L +L TLD+++NQL +P E+ +C ++ ++ + N+L D
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
Score = 69.7 bits (169), Expect = 7e-12
Identities = 56/178 (31%), Positives = 83/178 (46%), Gaps = 17/178 (9%)
Query: 77 LHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNL 136
L L L N + L L L L L+ N + P G GP++ + SLN+
Sbjct: 309 LEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG---GPSQ---FSTIYSLNM 362
Query: 137 SGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP 196
NR+ ++P + A L LN+ N L S P + G + EL A N L ++
Sbjct: 363 EHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF---GTWTSMVELNLATNQLTKIPE 419
Query: 197 DIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD--------KRLEKMV 246
D++ L SL+ L LSNN L ++P L + KL+E++ NKL K L+K+V
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLV 477
Score = 62.8 bits (151), Expect = 9e-10
Identities = 61/211 (28%), Positives = 92/211 (43%), Gaps = 27/211 (12%)
Query: 74 LPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPG--------------QG 119
L L +L L N+L L L L LR+LDL N L +P
Sbjct: 145 LVNLMTLALSENSL-TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR 203
Query: 120 LGPAEPP--GLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGA 177
+ E L +L L++ N++++LPA++ L +L++ N L+ P E+ G
Sbjct: 204 ITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELC-NLITLDVAHNQLEHLPKEI---GN 259
Query: 178 LPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
++ L N L +L I +L+SL L L N+LS IP LA C L+E+N N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
Query: 238 RD------KRLEKMVSGCQTRSILEYLRVGG 262
L K+ S R+ + VGG
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGG 350
Score = 56.2 bits (134), Expect = 8e-08
Identities = 49/159 (30%), Positives = 74/159 (46%), Gaps = 12/159 (7%)
Query: 77 LHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNL 136
L L ++ N L L + G ++ L+L+ N L +P + GL L+ L L
Sbjct: 381 LSKLNMKDNQL-TSLPLDFGTWTSMVELNLATNQLTKIPE-------DVSGLVSLEVLIL 432
Query: 137 SGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP 196
S N L++LP L +L+ L+L N L+S P E+ L L +L +N L L
Sbjct: 433 SNNLLKKLPHGLGNLR-KLRELDLEENKLESLPNEI---AYLKDLQKLVLTNNQLTTLPR 488
Query: 197 DIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGN 235
I HL +L L L N L+ +P E+ L+E+ N
Sbjct: 489 GIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/137 (31%), Positives = 65/137 (47%), Gaps = 11/137 (8%)
Query: 101 LRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNL 160
L L++ N L +LP G + + LNL+ N+L ++P D++ L+ L L
Sbjct: 381 LSKLNMKDNQLTSLPLDFGTWTS-------MVELNLATNQLTKIPEDVSGLVS-LEVLIL 432
Query: 161 TGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAE 220
+ N L P L G L L EL +N L L +IA+L L+ L L+NNQL+ +P
Sbjct: 433 SNNLLKKLPHGL---GNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRG 489
Query: 221 LADCPKLKEINFRGNKL 237
+ L + N L
Sbjct: 490 IGHLTNLTHLGLGENLL 506
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 70.5 bits (171), Expect = 4e-12
Identities = 93/303 (30%), Positives = 118/303 (38%), Gaps = 62/303 (20%)
Query: 29 PGLEERVRAAGGQL---PPRLFT-LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRR 84
P L +R+ G L P F +P L +L++ C + G +GL +L L L
Sbjct: 61 PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHC-EVELVAEGAFRGLGRLLLLNLAS 119
Query: 85 NALGPGLSPELGPLPALRVLDLSGNALEALPPG--------------------------Q 118
N L L L +LR L+L GNALE L PG Q
Sbjct: 120 NHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQ 179
Query: 119 G----------------LGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTG 162
G L P GLP L+ L+L N L+ LP + A L L L
Sbjct: 180 GLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGH 239
Query: 163 NCLDSFPAELFRPGALPLLSELAAADNCLRELSP-DIAHLASLKTLDLSNNQLSEIPAEL 221
N L E ALP L EL L+ L P AH L TLDL NQL +P L
Sbjct: 240 NPLTYAGEE--DGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP-PL 296
Query: 222 ADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYL---RVGGRGGGKGKGRAEGSEKE 278
+L+ + +GN L GCQ R +LE+L RV G +G R G +
Sbjct: 297 QGPGQLRRLRLQGNPL--------WCGCQARPLLEWLARARVRSDGACQGPRRLRGEALD 348
Query: 279 ESR 281
R
Sbjct: 349 ALR 351
Score = 65.9 bits (159), Expect = 1e-10
Identities = 64/188 (34%), Positives = 91/188 (48%), Gaps = 11/188 (5%)
Query: 50 PLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGN 109
P L YL + L+ PG L + LP L SL L+ NA+ +LG ALR + LSGN
Sbjct: 497 PRLGYLYLERNRFLQVPGAAL-RALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555
Query: 110 ALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFP 169
+ + G LGPA +L+ L+L N+LRE+P P L L L+GN L +
Sbjct: 556 RITEVSLG-ALGPAR-----ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
Query: 170 AELFRPGALPLLSELAAADNCLRELSPD-IAHLA-SLKTLDLSNNQLSEIPAELADCPKL 227
F+P L L + L ++ P + L L++L L NQL +PA L +L
Sbjct: 610 DGAFQPVGRS-LQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA-LPSLSQL 667
Query: 228 KEINFRGN 235
+ I+ N
Sbjct: 668 ELIDLSSN 675
Score = 57.0 bits (136), Expect = 5e-08
Identities = 73/237 (30%), Positives = 92/237 (38%), Gaps = 36/237 (15%)
Query: 28 GPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLV-LRRN- 85
GPG E V P +P + GCG P +G P L+ LRRN
Sbjct: 386 GPGEERAVAPC----PRACVCVPESRHSSCEGCGLQAVP-----RGFPSDTQLLDLRRNH 436
Query: 86 --ALGPGLSPELGPLPALR-----VLDLSGNALEALP----------PGQGLGPAEPPGL 128
++ P LG L +L + +L AL L GL A G
Sbjct: 437 FPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGA 496
Query: 129 PQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSF-PAELFRPGAL--PLLSELA 185
P+L L L NR ++P R P L SL+L N +D P +L R AL LS
Sbjct: 497 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNR 556
Query: 186 AADNCLRELSPDIAHLASLKTLDLSNNQLSEIP-AELADCPKLKEINFRGNKLRDKR 241
+ L L P L+ L L NQL E+P L P L E+ GN LR R
Sbjct: 557 ITEVSLGALGP----ARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
Score = 54.3 bits (129), Expect = 3e-07
Identities = 69/178 (38%), Positives = 81/178 (45%), Gaps = 33/178 (18%)
Query: 22 RELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLA-QGLPQLHSL 80
R L L G LEE G L L TL L H V P +A QGL ++ L
Sbjct: 137 RRLELEGNALEELRPGTFGALGA-LATLNLAHNALVYL--------PAMAFQGLLRVRWL 187
Query: 81 VLRRNALGPGLSPE-LGPLPALRVLDLSGNALEALP-----PGQGL-------------G 121
L NAL L+PE L LPALR L L N L+ALP +GL G
Sbjct: 188 RLSHNALSV-LAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 122 PAEPPGLPQLQSLNLSGNRLREL-PADLARCAPRLQSLNLTGNCLDSFPAELFRPGAL 178
+ LP L+ L L G L+ L P A C PRL +L+L GN LD+ P L PG L
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHC-PRLHTLDLRGNQLDTLP-PLQGPGQL 302
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 70.5 bits (171), Expect = 4e-12
Identities = 43/109 (39%), Positives = 63/109 (57%), Gaps = 4/109 (3%)
Query: 127 GLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAA 186
GL ++Q LNLS N+LR LP ++ + R+ LNL GN L S P E+ L L L
Sbjct: 69 GLSEVQKLNLSHNQLRVLPPEVGKLT-RIVVLNLCGNRLKSLPREV---SLLQCLKVLFV 124
Query: 187 ADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGN 235
NCL E+ +++ L+ L LS+N LS++PA AD +L+++N N
Sbjct: 125 NMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
Score = 65.1 bits (157), Expect = 2e-10
Identities = 59/187 (31%), Positives = 83/187 (44%), Gaps = 21/187 (11%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGL------- 120
P GL ++ L L N L L PE+G L + VL+L GN L++LP L
Sbjct: 64 PDFLWGLSEVQKLNLSHNQLRV-LPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
Query: 121 ---------GPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAE 171
PAE +L+ L+LS N L +LPA A + RL+ LNL+ N P
Sbjct: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLS-RLRKLNLSNNFFAHIPMC 181
Query: 172 LFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEIN 231
+F +L L L N L ++ I HLASL+ N + P L L+ +N
Sbjct: 182 VF---SLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLN 238
Query: 232 FRGNKLR 238
N ++
Sbjct: 239 LNNNDIQ 245
Score = 63.5 bits (153), Expect = 5e-10
Identities = 51/144 (35%), Positives = 74/144 (51%), Gaps = 15/144 (10%)
Query: 98 LPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPAD--LARCAPRL 155
L ++ L+LS N L LPP G L ++ LNL GNRL+ LP + L +C L
Sbjct: 70 LSEVQKLNLSHNQLRVLPPEVGK-------LTRIVVLNLCGNRLKSLPREVSLLQC---L 119
Query: 156 QSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLS 215
+ L + NCL PAEL L +LS + NCL +L A L+ L+ L+LSNN +
Sbjct: 120 KVLFVNMNCLTEVPAELSLCRKLEVLS---LSHNCLSQLPACFADLSRLRKLNLSNNFFA 176
Query: 216 EIPAELADCPKLKEINFRGNKLRD 239
IP + +L ++ N+L +
Sbjct: 177 HIPMCVFSLKELIFLHVGSNRLEN 200
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/55 (34%), Positives = 32/55 (58%), Gaps = 2/55 (3%)
Query: 201 LASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSIL 255
L+ ++ L+LS+NQL +P E+ ++ +N GN+L K L + VS Q +L
Sbjct: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRL--KSLPREVSLLQCLKVL 122
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 69.7 bits (169), Expect = 7e-12
Identities = 83/260 (31%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 55 LEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEAL 114
LE+SG R P A L +L L + L L E+ L LR+L L N LE L
Sbjct: 26 LELSGRRLRRLPSAVCA--LSRLQKLYVSGTGLRE-LPEEIEELRELRILALDFNKLERL 82
Query: 115 PPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFR 174
P G LP+L L L GNRL LPAD A+ L+ L + GN L FP L R
Sbjct: 83 PDGLCR-------LPRLTRLYLGGNRLLALPADFAQLQS-LRCLWIEGNFLRRFPRPLLR 134
Query: 175 PGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRG 234
L L L DN LR L ++ + L+ L L N+ E P L +L ++
Sbjct: 135 ---LVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDR 191
Query: 235 NK------LRDKRLEKMVSGCQTRSILEYLRVGGRGGGKGKGRAEG-SEKEESRRKRRER 287
N+ L R ++ S + RV G+G E +E++E + R
Sbjct: 192 NRLGGFPDLHPLRALRVFS-YDHNPVTGPPRVADTVFLVGEGAVERMAERDEPTPRPPPR 250
Query: 288 KQRREGGDGEEQD--VGDAG 305
+ R D EE+D +G AG
Sbjct: 251 RPARAFEDEEEEDLLIGGAG 270
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/108 (38%), Positives = 52/108 (48%), Gaps = 6/108 (5%)
Query: 132 QSLNLSGNRLRELPADLARCA-PRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNC 190
Q L LSG RLR LP+ A CA RLQ L ++G L P E+ L L LA N
Sbjct: 24 QQLELSGRRLRRLPS--AVCALSRLQKLYVSGTGLRELPEEI---EELRELRILALDFNK 78
Query: 191 LRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
L L + L L L L N+L +PA+ A L+ + GN LR
Sbjct: 79 LERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLR 126
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 68.9 bits (167), Expect = 1e-11
Identities = 70/213 (32%), Positives = 94/213 (44%), Gaps = 27/213 (12%)
Query: 47 FTLPLLHYLEVSGCGSLRA-PGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLD 105
F+L L L++S C S+ A Q QL L LR N L P+L LP L L+
Sbjct: 215 FSLQQLRVLDLS-CNSIEAFQTASQPQAEFQLTWLDLRENKLLH--FPDLAALPRLIYLN 271
Query: 106 LSGNALE--------------------ALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELP 145
LS N + ALP G A L QL +L+LS N + +P
Sbjct: 272 LSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIP 331
Query: 146 ADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLK 205
L LNL+ NCL +F A R G+LP L L + N L L L SL+
Sbjct: 332 DSFLEHLTSLCFLNLSRNCLRTFEAR--RLGSLPCLMLLDLSHNALETLELGARALGSLR 389
Query: 206 TLDLSNNQLSEIPA-ELADCPKLKEINFRGNKL 237
TL L N L ++P A+ L+ +N +GN++
Sbjct: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
Score = 57.4 bits (137), Expect = 4e-08
Identities = 58/168 (34%), Positives = 77/168 (45%), Gaps = 12/168 (7%)
Query: 75 PQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSL 134
P +L L N L L+ LG ALR LDLS N + L PG L L+ L
Sbjct: 49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAF------QALTHLEHL 102
Query: 135 NLSGNRL---RELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCL 191
+L+ NRL L A PR+ SL+L+GN L S E G P L L+ A+N L
Sbjct: 103 SLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL-GEAPSLHTLSLAENSL 161
Query: 192 RELS-PDIAHLASLKTLDLSNNQLSEI-PAELADCPKLKEINFRGNKL 237
L+ + +L+ LDL +N L +I P+L +N N L
Sbjct: 162 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/151 (34%), Positives = 65/151 (43%), Gaps = 14/151 (9%)
Query: 74 LPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQS 133
L L L L RN L + LG LP L +LDLS NALE L G L L++
Sbjct: 338 LTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELG-------ARALGSLRT 390
Query: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCL-------DSFPAELFRPGALPLLSELAA 186
L L GN LR+LP LQ LNL GN + + P+ + L L+
Sbjct: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
Query: 187 ADNCLRELSPDIAHLASLKTLDLSNNQLSEI 217
DN + L L LDLS+N E+
Sbjct: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEV 481
Score = 48.9 bits (115), Expect = 1e-05
Identities = 73/216 (33%), Positives = 93/216 (43%), Gaps = 40/216 (18%)
Query: 69 GLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGL 128
G +GLP+L L L RN+L L LRVLDLS N++EA ++P
Sbjct: 191 GAFEGLPRLTHLNLSRNSL---TCISDFSLQQLRVLDLSCNSIEAFQTA-----SQPQAE 242
Query: 129 PQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCL--------DS----FPAELFRPG 176
QL L+L N+L P DLA PRL LNL+ N + DS P+E +
Sbjct: 243 FQLTWLDLRENKLLHFP-DLA-ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW--S 298
Query: 177 ALPL-----------LSELAAADNCLR--ELSPD--IAHLASLKTLDLSNNQLSEIPA-E 220
ALPL LS+L D EL PD + HL SL L+LS N L A
Sbjct: 299 ALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARR 358
Query: 221 LADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILE 256
L P L ++ N L L G +L+
Sbjct: 359 LGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQ 394
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 68.9 bits (167), Expect = 1e-11
Identities = 70/213 (32%), Positives = 94/213 (44%), Gaps = 27/213 (12%)
Query: 47 FTLPLLHYLEVSGCGSLRA-PGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLD 105
F+L L L++S C S+ A Q QL L LR N L P+L LP L L+
Sbjct: 215 FSLQQLRVLDLS-CNSIEAFQTASQPQAEFQLTWLDLRENKLLH--FPDLAALPRLIYLN 271
Query: 106 LSGNALE--------------------ALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELP 145
LS N + ALP G A L QL +L+LS N + +P
Sbjct: 272 LSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIP 331
Query: 146 ADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLK 205
L LNL+ NCL +F A R G+LP L L + N L L L SL+
Sbjct: 332 DSFLEHLTSLCFLNLSRNCLRTFEAR--RLGSLPCLMLLDLSHNALETLELGARALGSLR 389
Query: 206 TLDLSNNQLSEIPA-ELADCPKLKEINFRGNKL 237
TL L N L ++P A+ L+ +N +GN++
Sbjct: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
Score = 57.4 bits (137), Expect = 4e-08
Identities = 58/168 (34%), Positives = 77/168 (45%), Gaps = 12/168 (7%)
Query: 75 PQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSL 134
P +L L N L L+ LG ALR LDLS N + L PG L L+ L
Sbjct: 49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAF------QALTHLEHL 102
Query: 135 NLSGNRL---RELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCL 191
+L+ NRL L A PR+ SL+L+GN L S E G P L L+ A+N L
Sbjct: 103 SLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL-GEAPSLHTLSLAENSL 161
Query: 192 RELS-PDIAHLASLKTLDLSNNQLSEI-PAELADCPKLKEINFRGNKL 237
L+ + +L+ LDL +N L +I P+L +N N L
Sbjct: 162 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/151 (34%), Positives = 65/151 (43%), Gaps = 14/151 (9%)
Query: 74 LPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQS 133
L L L L RN L + LG LP L +LDLS NALE L G L L++
Sbjct: 338 LTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELG-------ARALGSLRT 390
Query: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCL-------DSFPAELFRPGALPLLSELAA 186
L L GN LR+LP LQ LNL GN + + P+ + L L+
Sbjct: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
Query: 187 ADNCLRELSPDIAHLASLKTLDLSNNQLSEI 217
DN + L L LDLS+N E+
Sbjct: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEV 481
Score = 48.9 bits (115), Expect = 1e-05
Identities = 73/216 (33%), Positives = 93/216 (43%), Gaps = 40/216 (18%)
Query: 69 GLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGL 128
G +GLP+L L L RN+L L LRVLDLS N++EA ++P
Sbjct: 191 GAFEGLPRLTHLNLSRNSL---TCISDFSLQQLRVLDLSCNSIEAFQTA-----SQPQAE 242
Query: 129 PQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCL--------DS----FPAELFRPG 176
QL L+L N+L P DLA PRL LNL+ N + DS P+E +
Sbjct: 243 FQLTWLDLRENKLLHFP-DLA-ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW--S 298
Query: 177 ALPL-----------LSELAAADNCLR--ELSPD--IAHLASLKTLDLSNNQLSEIPA-E 220
ALPL LS+L D EL PD + HL SL L+LS N L A
Sbjct: 299 ALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARR 358
Query: 221 LADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILE 256
L P L ++ N L L G +L+
Sbjct: 359 LGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQ 394
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 68.9 bits (167), Expect = 1e-11
Identities = 62/200 (31%), Positives = 91/200 (45%), Gaps = 11/200 (5%)
Query: 41 QLPPRLFT-LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLP 99
+L P LF L L L +SG PG + GL L L+L+ N LG + L LP
Sbjct: 28 ELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS-GLYSLKILMLQNNQLGGIPAEALWELP 86
Query: 100 ALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLN 159
+L+ L L N + +P GL L+ L L N L E+P P LQ++
Sbjct: 87 SLQSLRLDANLISLVPERSF------EGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
Query: 160 LTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP-DIAHLASLKTLDLSNNQLSEIP 218
L N + P F+ L L L +N ++ L L +L+TLDL+ N+L E P
Sbjct: 141 LALNRISHIPDYAFQN--LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 198
Query: 219 AELADCPKLKEINFRGNKLR 238
+ +L+E+ F N ++
Sbjct: 199 VAIRTLGRLQELGFHNNNIK 218
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 32/160 (20%)
Query: 98 LPALRVLDLSGNA-LEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQ 156
LP L L L+G ++ P + G L+ L L+ +R LP+ + + PRL+
Sbjct: 252 LPKLHTLSLNGAMDIQEFP--------DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLR 303
Query: 157 SLNLTGNCLDSFPA---------------ELFRPGA--LPLLSELAAAD---NCLRELSP 196
L L+ N ++ P+ ++ GA LS L A D N +R + P
Sbjct: 304 VLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHP 363
Query: 197 D-IAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGN 235
+ + L SL LDL++NQL+ +P LA L + +GN
Sbjct: 364 EAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGN 401
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 68.9 bits (167), Expect = 1e-11
Identities = 62/200 (31%), Positives = 91/200 (45%), Gaps = 11/200 (5%)
Query: 41 QLPPRLFT-LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLP 99
+L P LF L L L +SG PG + GL L L+L+ N LG + L LP
Sbjct: 80 ELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS-GLYSLKILMLQNNQLGGIPAEALWELP 138
Query: 100 ALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLN 159
+L+ L L N + +P GL L+ L L N L E+P P LQ++
Sbjct: 139 SLQSLRLDANLISLVPERSF------EGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 192
Query: 160 LTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP-DIAHLASLKTLDLSNNQLSEIP 218
L N + P F+ L L L +N ++ L L +L+TLDL+ N+L E P
Sbjct: 193 LALNRISHIPDYAFQN--LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 219 AELADCPKLKEINFRGNKLR 238
+ +L+E+ F N ++
Sbjct: 251 VAIRTLGRLQELGFHNNNIK 270
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 32/160 (20%)
Query: 98 LPALRVLDLSGNA-LEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQ 156
LP L L L+G ++ P + G L+ L L+ +R LP+ + + PRL+
Sbjct: 304 LPKLHTLSLNGAMDIQEFP--------DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLR 355
Query: 157 SLNLTGNCLDSFPA---------------ELFRPGA--LPLLSELAAAD---NCLRELSP 196
L L+ N ++ P+ ++ GA LS L A D N +R + P
Sbjct: 356 VLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHP 415
Query: 197 D-IAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGN 235
+ + L SL LDL++NQL+ +P LA L + +GN
Sbjct: 416 EAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGN 453
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 68.6 bits (166), Expect = 2e-11
Identities = 62/203 (30%), Positives = 96/203 (47%), Gaps = 16/203 (7%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
+PP++F LP L +LE++ G QGL L SL ++RN + + L +
Sbjct: 207 IPPKMFKLPQLQHLELNRNKIKNVDGLTF-QGLGALKSLKMQRNGVTKLMDGAFWGLSNM 265
Query: 102 RVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLT 161
+L L N L + G G L LQ L+LS N + + D +L L+LT
Sbjct: 266 EILQLDHNNLTEITKGWLYG------LLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 319
Query: 162 GNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAH--LASLKTLDLSNNQLS---- 215
N L F L LL+ L +N + ++ D A L+SLKTLDL NN++S
Sbjct: 320 FNHLSRLDDSSFL--GLSLLNTLHIGNNRVSYIA-DCAFRGLSSLKTLDLKNNEISWTIE 376
Query: 216 EIPAELADCPKLKEINFRGNKLR 238
++ + KL+ + +GN++R
Sbjct: 377 DMNGAFSGLDKLRRLILQGNRIR 399
Score = 45.8 bits (107), Expect = 1e-04
Identities = 44/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)
Query: 80 LVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGN 139
L L N L + + L +LR + L+ N LE +P LGP + L+L+GN
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP---NLGPVSA----NITLLSLAGN 131
Query: 140 RLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPD-I 198
R+ E+ + + L++L+L+ N + +EL L L N + + P
Sbjct: 132 RIVEILPEHLKEFQSLETLDLSSNNI----SELQTAFPALQLKYLYLNSNRVTSMEPGYF 187
Query: 199 AHLAS-LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD 239
+LA+ L L L+ N++S IP ++ P+L+ + NK+++
Sbjct: 188 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKN 229
Score = 29.6 bits (65), Expect = 8.0
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 73 GLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQ 132
GL L++L + N + L +L+ LDL N + GL +L+
Sbjct: 333 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN---GAFSGLDKLR 389
Query: 133 SLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELF 173
L L GNR+R + L+ L+L+ N + S F
Sbjct: 390 RLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 430
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 68.6 bits (166), Expect = 2e-11
Identities = 62/203 (30%), Positives = 96/203 (47%), Gaps = 16/203 (7%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
+PP++F LP L +LE++ G QGL L SL ++RN + + L +
Sbjct: 147 IPPKMFKLPQLQHLELNRNKIKNVDGLTF-QGLGALKSLKMQRNGVTKLMDGAFWGLSNM 205
Query: 102 RVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLT 161
+L L N L + G G L LQ L+LS N + + D +L L+LT
Sbjct: 206 EILQLDHNNLTEITKGWLYG------LLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 259
Query: 162 GNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAH--LASLKTLDLSNNQLS---- 215
N L F L LL+ L +N + ++ D A L+SLKTLDL NN++S
Sbjct: 260 FNHLSRLDDSSFL--GLSLLNTLHIGNNRVSYIA-DCAFRGLSSLKTLDLKNNEISWTIE 316
Query: 216 EIPAELADCPKLKEINFRGNKLR 238
++ + KL+ + +GN++R
Sbjct: 317 DMNGAFSGLDKLRRLILQGNRIR 339
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 13/160 (8%)
Query: 82 LRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRL 141
L N L + + L +LR + L+ N LE +P LGP + L+L+GNR+
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP---NLGPVSA----NITLLSLAGNRI 73
Query: 142 RELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPD-IAH 200
E+ + + L++L+L+ N + +EL L L N + + P +
Sbjct: 74 VEILPEHLKEFQSLETLDLSSNNI----SELQTAFPALQLKYLYLNSNRVTSMEPGYFDN 129
Query: 201 LAS-LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD 239
LA+ L L L+ N++S IP ++ P+L+ + NK+++
Sbjct: 130 LANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKN 169
Score = 29.6 bits (65), Expect = 8.0
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 73 GLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQ 132
GL L++L + N + L +L+ LDL N + GL +L+
Sbjct: 273 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN---GAFSGLDKLR 329
Query: 133 SLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELF 173
L L GNR+R + L+ L+L+ N + S F
Sbjct: 330 RLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 370
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/163 (34%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 76 QLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLN 135
+L L L N L L PELG L L++L L N +ALP L QL L
Sbjct: 53 ELVKLYLSDNHLN-SLPPELGQLQNLQILALDFNNFKALPQVVCT-------LKQLCILY 104
Query: 136 LSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELS 195
L N+L +LP++L+ L++L + NCL P + L LL L A N LR L
Sbjct: 105 LGNNKLCDLPSELS-LLQNLRTLWIEANCLTQLPDVVCE---LSLLKTLHAGSNALRLLP 160
Query: 196 PDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
+ L L+T+ LS N+L++ P L P L+ I+ N +R
Sbjct: 161 GQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
Score = 52.8 bits (125), Expect = 9e-07
Identities = 47/136 (34%), Positives = 61/136 (44%), Gaps = 11/136 (8%)
Query: 104 LDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGN 163
L LS N L +LPP G L LQ L L N + LP + +L L L N
Sbjct: 57 LYLSDNHLNSLPPELGQ-------LQNLQILALDFNNFKALP-QVVCTLKQLCILYLGNN 108
Query: 164 CLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELAD 223
L P+EL L L L NCL +L + L+ LKTL +N L +P +L
Sbjct: 109 KLCDLPSEL---SLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRR 165
Query: 224 CPKLKEINFRGNKLRD 239
+L+ I GN+L D
Sbjct: 166 LQELRTIWLSGNRLTD 181
Score = 49.7 bits (117), Expect = 7e-06
Identities = 58/177 (32%), Positives = 77/177 (43%), Gaps = 15/177 (8%)
Query: 42 LPPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPAL 101
LPP L L L L + + +A P + L QL L L N L L EL L L
Sbjct: 67 LPPELGQLQNLQILALD-FNNFKAL-PQVVCTLKQLCILYLGNNKLCD-LPSELSLLQNL 123
Query: 102 RVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLT 161
R L + N L LP L L++L+ N LR LP L R L+++ L+
Sbjct: 124 RTLWIEANCLTQLPD-------VVCELSLLKTLHAGSNALRLLPGQLRRLQ-ELRTIWLS 175
Query: 162 GNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIP 218
GN L FP L +P L + N +R P +AHL+SLK + +N P
Sbjct: 176 GNRLTDFPTVLLH---MPFLEVIDVDWNSIRYF-PSLAHLSSLKLVIYDHNPCRNAP 228
Score = 36.2 bits (82), Expect = 0.086
Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 15/101 (14%)
Query: 141 LRELPADLARCAPRLQSLNLTGNCLDSFPAEL--FRPGALPLLSELAAADNCLRELSPDI 198
LRE+P D + ++L+G+ L FP + FR L +L +DN L L P++
Sbjct: 25 LREMPLD--------KMVDLSGSQLRRFPLHVCSFRE-----LVKLYLSDNHLNSLPPEL 71
Query: 199 AHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD 239
L +L+ L L N +P + +L + NKL D
Sbjct: 72 GQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 66.6 bits (161), Expect = 6e-11
Identities = 54/155 (34%), Positives = 77/155 (49%), Gaps = 9/155 (5%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
P GLP+L L + ++ + L +L L L+ N LEALP G
Sbjct: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF------QH 143
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L L+SL+L GN+L+ LP L + L++LNL N L P ELF P L L L +
Sbjct: 144 LAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHP--LTSLQTLKLS 201
Query: 188 DNCLRELSPDI-AHLASLKTLDLSNNQLSEIPAEL 221
+N L L + L SL+ L L +N +SE+P ++
Sbjct: 202 NNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV 236
Score = 56.6 bits (135), Expect = 6e-08
Identities = 66/217 (30%), Positives = 91/217 (41%), Gaps = 24/217 (11%)
Query: 42 LPPRLFT-LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPA 100
LP LF L L L + G L+A L Q L L +L L +N L PL +
Sbjct: 136 LPEGLFQHLAALESLHLQG-NQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTS 194
Query: 101 LRVLDLSGNALEALPPG---------------QGLGPAEPPGLPQL---QSLNLSGNRLR 142
L+ L LS NAL LP G + P QL + L L N +
Sbjct: 195 LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAIT 254
Query: 143 ELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP-DIAHL 201
LP + L L+L N L PA LF P L L+ N L ++ AHL
Sbjct: 255 HLPLSIFASLGNLTFLSLQWNMLRVLPAGLF--AHTPCLVGLSLTHNQLETVAEGTFAHL 312
Query: 202 ASLKTLDLSNNQLSEIPAEL-ADCPKLKEINFRGNKL 237
++L++L LS N ++ +PA + D +L ++ N L
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNL 349
Score = 38.9 bits (89), Expect = 0.013
Identities = 33/111 (29%), Positives = 48/111 (43%), Gaps = 4/111 (3%)
Query: 129 PQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAAD 188
P L + +L + D PRL+ L +TG+ + +F L L +L
Sbjct: 73 PNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIF--SNLTSLGKLTLNF 130
Query: 189 NCLRELSPDI-AHLASLKTLDLSNNQLSEIPAEL-ADCPKLKEINFRGNKL 237
N L L + HLA+L++L L NQL +P L LK +N N L
Sbjct: 131 NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
Score = 35.0 bits (79), Expect = 0.19
Identities = 36/125 (28%), Positives = 49/125 (39%), Gaps = 31/125 (24%)
Query: 99 PALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSL 158
P L L L+ N LE + G L L+SL LS N + LPA + R L L
Sbjct: 289 PCLVGLSLTHNQLETVAEGTFAH------LSNLRSLMLSYNAITHLPAGIFRDLEELVKL 342
Query: 159 NLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIP 218
L N L + LF+ +L+ L+ L LS NQL+ +P
Sbjct: 343 YLGSNNLTALHPALFQ-------------------------NLSKLELLSLSKNQLTTLP 377
Query: 219 AELAD 223
+ D
Sbjct: 378 EGIFD 382
Score = 34.7 bits (78), Expect = 0.25
Identities = 36/111 (32%), Positives = 45/111 (40%), Gaps = 6/111 (5%)
Query: 63 LRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGP 122
LR GL P L L L N L L LR L LS NA+ LP G
Sbjct: 277 LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIF--- 333
Query: 123 AEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELF 173
L +L L L N L L L + +L+ L+L+ N L + P +F
Sbjct: 334 ---RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIF 381
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 66.6 bits (161), Expect = 6e-11
Identities = 74/216 (34%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 30 GLEERVRA-----AGGQLPPRLFT-LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLR 83
GLE V+ A G LP +F L L YL + +R G L +L L L
Sbjct: 153 GLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES-NRIRFLGKNAFAQLGKLRFLNLS 211
Query: 84 RNALGPGL--SPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRL 141
N L P L + PL +L L LS N L Q LGP LP+L L+L GN+L
Sbjct: 212 ANELQPSLRHAATFAPLRSLSSLILSANNL------QHLGPRIFQHLPRLGLLSLRGNQL 265
Query: 142 RELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP-DIAH 200
L + L+ L L GN L P L P L L L + N L L P H
Sbjct: 266 THLAPEAFWGLEALRELRLEGNRLSQLPTALLEP--LHSLEALDLSGNELSALHPATFGH 323
Query: 201 LASLKTLDLSNNQLSEIPAEL-ADCPKLKEINFRGN 235
L L+ L L NN LS + ++ A P L ++ GN
Sbjct: 324 LGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 54.3 bits (129), Expect = 3e-07
Identities = 58/181 (32%), Positives = 75/181 (41%), Gaps = 8/181 (4%)
Query: 59 GCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQ 118
G L+A PG L +L L N + L +L L L GNAL ALP
Sbjct: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALP--- 171
Query: 119 GLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGAL 178
A L L L+L NR+R L + +L+ LNL+ N L L
Sbjct: 172 ---DAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPL 228
Query: 179 PLLSELAAADNCLRELSPDI-AHLASLKTLDLSNNQLSEI-PAELADCPKLKEINFRGNK 236
LS L + N L+ L P I HL L L L NQL+ + P L+E+ GN+
Sbjct: 229 RSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNR 288
Query: 237 L 237
L
Sbjct: 289 L 289
Score = 52.8 bits (125), Expect = 9e-07
Identities = 57/185 (30%), Positives = 76/185 (41%), Gaps = 24/185 (12%)
Query: 63 LRAPGPGLAQGLPQLHSLVLRRN---ALGPGLSPELGPLPALRVLDLSGNALEALPPGQG 119
+R+ P + L +L L L N AL PG L PL LR+L +GN + L G
Sbjct: 95 IRSLHPKTFEKLSRLEELYLGNNLLQALAPGT---LAPLRKLRILYANGNEISRLSRGSF 151
Query: 120 LGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALP 179
GL L L L GN L LP + L L+L N + A
Sbjct: 152 ------EGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRI-----RFLGKNAFA 200
Query: 180 LLSELAAADNCLRELSPDIAH------LASLKTLDLSNNQLSEI-PAELADCPKLKEINF 232
L +L + EL P + H L SL +L LS N L + P P+L ++
Sbjct: 201 QLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSL 260
Query: 233 RGNKL 237
RGN+L
Sbjct: 261 RGNQL 265
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 66.2 bits (160), Expect = 8e-11
Identities = 69/209 (33%), Positives = 99/209 (47%), Gaps = 22/209 (10%)
Query: 22 RELLLTGPGLEERVRAAGGQLPPRLFTLPLLHYLEVSGCGSLRAPGPGLA-QGLPQLHSL 80
REL L GLE ++P +F+L L L++ LR+ L+ Q +L +L
Sbjct: 585 RELELVACGLE--------RIPHAVFSLGALQELDLKD-NHLRSIEEILSFQHCRKLVTL 635
Query: 81 VLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNR 140
L N + + + L +L L LS N LE LP GL L+ L++S N
Sbjct: 636 RLWHNQIAY-VPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSG-------LRLLDVSHNG 687
Query: 141 LRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAH 200
L LP ++ LQ L L+ N L++ P ELF L L DN L +LSP +
Sbjct: 688 LHSLPPEVG-LLQNLQHLALSYNALEALPEELF---FCRKLRTLLLGDNQLSQLSPHVGA 743
Query: 201 LASLKTLDLSNNQLSEIPAELADCPKLKE 229
L +L L+L N+L +P EL +C LK+
Sbjct: 744 LRALSRLELKGNRLEALPEELGNCGGLKK 772
Score = 56.2 bits (134), Expect = 8e-08
Identities = 38/110 (34%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L L+ L LS N+L LP+ L C+ L+ L+++ N L S P E+ G L L LA +
Sbjct: 652 LRSLEQLYLSYNKLETLPSQLGLCSG-LRLLDVSHNGLHSLPPEV---GLLQNLQHLALS 707
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
N L L ++ L+TL L +NQLS++ + L + +GN+L
Sbjct: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRL 757
Score = 44.7 bits (104), Expect = 2e-04
Identities = 50/170 (29%), Positives = 74/170 (43%), Gaps = 15/170 (8%)
Query: 72 QGLPQLHSLVLRRNALGPGLSPE-LGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLP- 129
+GL +LH L L + E L L L+VL L NA G PA +
Sbjct: 507 RGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA--------GKVPASVTDVAG 558
Query: 130 QLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADN 189
LQ L+L + R + + + L+ L L L+ P +F GAL EL DN
Sbjct: 559 HLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGAL---QELDLKDN 615
Query: 190 CLRELSPDIA--HLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
LR + ++ H L TL L +NQ++ +P + L+++ NKL
Sbjct: 616 HLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKL 665
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 65.9 bits (159), Expect = 1e-10
Identities = 65/211 (30%), Positives = 96/211 (45%), Gaps = 25/211 (11%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPG-------QGL 120
P + LH L+L N EL L L+VLDLS N L+ + Q L
Sbjct: 549 PASISNMISLHVLILCCNKFET-FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKL 607
Query: 121 G---------PAEPPGLPQLQSLNLS---GNRLRELPADLARCAPRLQSLNLTGNCLDSF 168
P E L L+ LN+S G +L LP +L+ +L+ L+++ N +
Sbjct: 608 NFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT-QLKELDISNNAIREI 666
Query: 169 PAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLK 228
P + G L L L A +N + L P + L L+ L+LS N L+ +P+ + + LK
Sbjct: 667 PRNI---GELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLK 723
Query: 229 EINFRGNKLRDKRLEKMVSGCQTRSILEYLR 259
EINF N L +E + G Q +I YL+
Sbjct: 724 EINFDDNPLLRPPVE-ICKGKQLYTIARYLQ 753
Score = 62.0 bits (149), Expect = 1e-09
Identities = 55/172 (31%), Positives = 81/172 (47%), Gaps = 12/172 (6%)
Query: 68 PGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPG 127
P + L L L L +N L + L L LRVL+L N L P
Sbjct: 250 PSDLECLGNLEILSLGKNKLRH-IPDTLPSLKTLRVLNLEYNQLTTFPKALCF------- 301
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
LP+L SL+L+GN + LP ++ R L++L + N L E+F+ L + EL A
Sbjct: 302 LPKLISLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQ---LLKIKELQLA 357
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRD 239
DN L +S I + L+ L L N L IP +++ C L+ ++ NKL +
Sbjct: 358 DNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
Score = 58.9 bits (141), Expect = 1e-08
Identities = 53/195 (27%), Positives = 99/195 (50%), Gaps = 14/195 (7%)
Query: 43 PPRLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALR 102
P L LP L L+++G +L + P + L L +L++ N L L+ E+ L ++
Sbjct: 296 PKALCFLPKLISLDLTG--NLISSLPKEIRELKNLETLLMDHNKL-TFLAVEIFQLLKIK 352
Query: 103 VLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTG 162
L L+ N LE + + +L+ L L N L+ +P ++ CA L+ L+L+
Sbjct: 353 ELQLADNKLEVISH-------KIENFRELRILILDKNLLKNIPEKISCCA-MLECLSLSD 404
Query: 163 NCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELA 222
N L P + + L L +L N + +++ I+HL ++ +L+ S N ++++P E+
Sbjct: 405 NKLTELPKYIHK---LNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
Query: 223 DCPKLKEINFRGNKL 237
+C K+ +I NK+
Sbjct: 462 NCQKIIKIELSYNKI 476
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 21/177 (11%)
Query: 77 LHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPG-QGLG-------------- 121
L L L+ N L L E+ L LR+L++S N + +P LG
Sbjct: 190 LEILSLQENGLS-SLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 122 -PAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPL 180
P++ L L+ L+L N+LR +P D L+ LNL N L +FP L LP
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIP-DTLPSLKTLRVLNLEYNQLTTFPKALC---FLPK 304
Query: 181 LSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
L L N + L +I L +L+TL + +N+L+ + E+ K+KE+ NKL
Sbjct: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
Score = 41.6 bits (96), Expect = 0.002
Identities = 35/129 (27%), Positives = 62/129 (48%), Gaps = 8/129 (6%)
Query: 133 SLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLR 192
++NL L+E P D+ + ++ L L N + +F G L L L+ +N L
Sbjct: 145 TVNLEAKGLQEFPKDILKIK-YVKYLYLDKNQIKTFQGA--DSGDLLGLEILSLQENGLS 201
Query: 193 ELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQTR 252
L +I L +L+ L++S+N +S IP E++ ++++ F N +E S +
Sbjct: 202 SLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN-----YIENFPSDLECL 256
Query: 253 SILEYLRVG 261
LE L +G
Sbjct: 257 GNLEILSLG 265
Score = 41.2 bits (95), Expect = 0.003
Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 13/134 (9%)
Query: 104 LDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCA-PRLQSLNLTG 162
L+ SGN + +P E ++ + LS N++ P L CA L L++ G
Sbjct: 446 LEFSGNIITDVP-------IEIKNCQKIIKIELSYNKIMYFPLGL--CALDSLYYLSVNG 496
Query: 163 NCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELA 222
N + P ++ L L ++N L S L +LK LDL NQ+ +IPA ++
Sbjct: 497 NYISEIPVDI---SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASIS 553
Query: 223 DCPKLKEINFRGNK 236
+ L + NK
Sbjct: 554 NMISLHVLILCCNK 567
Score = 38.5 bits (88), Expect = 0.017
Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 4/111 (3%)
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L + SL SGN + ++P ++ C ++ + L+ N + FP L AL L L+
Sbjct: 440 LNNICSLEFSGNIITDVPIEIKNCQ-KIIKIELSYNKIMYFPLGLC---ALDSLYYLSVN 495
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
N + E+ DI+ L L+LS N+L LK ++ N+++
Sbjct: 496 GNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546
Score = 37.7 bits (86), Expect = 0.029
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187
L L L+++GN + E+P D++ + +L L L+ N L F +L L L
Sbjct: 486 LDSLYYLSVNGNYISEIPVDIS-FSKQLLHLELSENKLLIFSEHFC---SLINLKYLDLG 541
Query: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLR 238
N ++++ I+++ SL L L N+ P EL L+ ++ N+L+
Sbjct: 542 KNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592
Score = 35.0 bits (79), Expect = 0.19
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 155 LQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQL 214
L+ L+L N L S P+E+ L L L + N + + +I+ L +++ L NN +
Sbjct: 190 LEILSLQENGLSSLPSEI---QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
Query: 215 SEIPAELADCPKLKEINFRGNKLR 238
P++L L+ ++ NKLR
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLR 270
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/163 (29%), Positives = 85/163 (52%), Gaps = 22/163 (13%)
Query: 101 LRVLDLSGNALEALPP-----------------GQGLGPAEPPGLPQLQSLNLSGNRLRE 143
LR +DLS N +E+LPP + P E L +L++L+L+ N LRE
Sbjct: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
Query: 144 LPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLAS 203
LP+ + + L++L+L+GN L + P +L +L L + + N +R + + L
Sbjct: 100 LPSTFGQLSA-LKTLSLSGNQLGALPPQLC---SLRHLDVMDLSKNQIRSIPDSVGELQV 155
Query: 204 LKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMV 246
++ L+L+ NQ+S+I +++ CP+LK + N L L + +
Sbjct: 156 IE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSI 197
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 2/102 (1%)
Query: 136 LSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELS 195
L L E PADL + L++++L+ N ++S P L G LL L+ +N L L
Sbjct: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLI--GKFTLLKSLSLNNNKLTVLP 78
Query: 196 PDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKL 237
+I +L L+TL L+NN L E+P+ LK ++ GN+L
Sbjct: 79 DEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL 120
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/159 (30%), Positives = 72/159 (45%), Gaps = 23/159 (14%)
Query: 74 LPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQS 133
L +L +L L N L L G L AL+ L LSGN L ALPP + L L
Sbjct: 84 LKKLETLSLNNNHLRE-LPSTFGQLSALKTLSLSGNQLGALPP-------QLCSLRHLDV 135
Query: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRE 193
++LS N++R +P + ++ LNL N + ++ P L L +NCL
Sbjct: 136 MDLSKNQIRSIPDSVGEL--QVIELNLNQNQISQISVKI---SCCPRLKILRLEENCL-- 188
Query: 194 LSPDIAHLASLKTLDLSNNQLSEIPAE--LADCPKLKEI 230
L+ L LS++Q+ + E L + KL+E+
Sbjct: 189 ------ELSMLPQSILSDSQICLLAVEGNLFEIKKLREL 221
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,331,744
Number of Sequences: 37866
Number of extensions: 1378435
Number of successful extensions: 9355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 244
Number of HSP's that attempted gapping in prelim test: 7065
Number of HSP's gapped (non-prelim): 1520
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.